Voltage-dependent N-type calcium channel subunit alpha-1B
Guanine nucleotide-binding protein subunit gamma
cAMP-dependent protein kinase catalytic subunit alpha
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
GABA-B receptor/ GABA/ G protein complex
Protein kinase cAMP-activated catalytic subunit beta
Potassium channel, inwardly rectifying subfamily J, member 3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
G protein-activated inward rectifier potassium channel 1
cAMP-dependent protein kinase catalytic subunit beta
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Gamma-aminobutyric acid type B receptor subunit 2
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
ENTITY_REFERENCE_NOTES=Long Name: Gi/oalpha Synonym: Synonym not specified Accession: P05757
Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
Potassium voltage-gated channel subfamily J member 3
Protein kinase cAMP-dependent type II regulatory subunit alpha
Protein kinase cAMP-dependent type I regulatory subunit alpha
Guanine nucleotide-binding protein G(k) subunit alpha
ENTITY_REFERENCE_NOTES= Long Name: Gbeta Synonym: Synonym not specified Accession: P05755
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Guanine nucleotide-binding protein G(i) subunit alpha-1
Inwardly rectifying potassium channel Kir3.1
ENTITY_REFERENCE_ID_DESC=GABA-B_receptor_II_signaling.PROTEIN.ION_CHANNEL.K channel
ENTITY_REFERENCE_NOTES=Long Name: Inwardly rectifying potassium channel Kir3.1 Synonym: GIRK1,KCNJ3 Accession: P05758
cAMP-dependent protein kinase type I-beta regulatory subunit
cAMP-dependent protein kinase type I-alpha regulatory subunit
Voltage-dependent T-type calcium channel subunit alpha-1G
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
cAMP-dependent protein kinase type II-beta regulatory subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
Guanine nucleotide-binding protein G(o) subunit alpha
Voltage-dependent T-type calcium channel subunit alpha
cAMP-dependent protein kinase type II-alpha regulatory subunit
Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
Guanine nucleotide-binding protein G(K) subunit alpha
Guanine nucleotide-binding protein subunit beta-4
Protein kinase cAMP-dependent type II regulatory subunit beta
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Gamma-aminobutyric acid type B receptor subunit 1
Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
MODEL_NOTES=Panther Pathway: P05731 GABA (gamma-aminobutyric acid) is the major inhibitory neurotransmitter in the central nervous system. It mediates its action through the ionotropic GABA-A and GABA-B receptors. GABA-A receptors form ion channels, while GABA-B receptors are G-protein coupled receptors. This pathway focuses on signaling pathway mediated by GABA-B receptor. GABA-B receptor are located on both presynaptic and postsynaptic membrane. Presynaptic GABA-B receptors are subdivided into autoreceptors that control GABA release, and heteroreceptors that inhibits all other neurotransmitter release. Upon binding to GABA, the presynaptic GABA-B receptor decreases Ca ion influx by inhibiting voltage-dependent Ca channels, particularly N-type and P/Q type, via beta and gamma subunit of G protein, thus lowering the presynaptic Ca concentration and decreasing neurotransmitter release. Postsynaptic GABA-B receptors induce a slow inhibitory postsynaptic current through the activation of an inward rectifying K channel (GIRK). In addition, recent studies found that synaptic plasticity can be controlled by the cAMP pathway. GABA-B receptors have been found to play a role in the field of substance abuse or addition. It has been reported that administration of GABA-B agonist, such as baclofen, can reduce patients' craving for cocaine or alcohol. Recently, an association study showed close linkage between several SNPs of GABA B2 receptor and nicotine dependency. Medline=11311380 Medline=16539894 OMIM=607340 PMID: 11311380 PMID: 16539894
cAMP-dependent protein kinase catalytic subunit
Protein kinase, cAMP-dependent, catalytic, beta
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
Voltage-dependent P/Q-type calcium channel subunit alpha
cAMP-dependent protein kinase catalytic subunit PRKX
cAMP-dependent protein kinase regulatory subunit
Guanine nucleotide-binding protein G(O) subunit alpha isoform a
Protein kinase, cAMP-dependent, regulatory, type I, beta
ENTITY_REFERENCE_NOTES= Long Name: Gamma-aminobutyric acid B receptor Synonym: GABBR2,G protein-coupled receptor 51 Accession: P05756
ENTITY_REFERENCE_NOTES= Long Name: Ggamma Synonym: Synonym not specified Accession: P05754
ENTITY_REFERENCE_NOTES=Long Name: Adenylate cyclase Synonym: adenylyl cyclase,adenyl cyclase Accession: P05760
ENTITY_REFERENCE_NOTES=Long Name: Voltage-dependent Ca channel Synonym: Synonym not specified Accession: P05753
ENTITY_REFERENCE_ID_DESC=GABA-B_receptor_II_signaling.PROTEIN.ION_CHANNEL.Ca channel
cAMP-dependent protein kinase catalytic subunit gamma
Protein kinase cAMP-activated catalytic subunit alpha
Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
Adenylyl CYclase family member (Acy-1)-like
Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
Voltage-dependent N-type calcium channel subunit alpha
ENTITY_REFERENCE_NOTES=Long Name: cAMP-dependent protein kinase Synonym: Synonym not specified Accession: P05752
cAMP-dependent protein kinase catalytic subunit beta isoform 1