uniprot K7ADQ0 234
type: UnificationXref
id: K7ADQ0
db: uniprot

uniprot A0A1D5RFY5 214
type: UnificationXref
id: A0A1D5RFY5
db: uniprot

Adenylate cyclase type 5
type: ProteinReference
xref: uniprot Q04400 252
xref: PTHR45627:SF7
organism: Rattus norvegicus

G protein subunit alpha i3
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot H2PZK9 96
organism: Pan troglodytes

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: PTHR45628:SF6
xref: uniprot Q02294 22
organism: Rattus norvegicus

uniprot Q9HAV0 212
type: UnificationXref
id: Q9HAV0
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: uniprot E1BHU9 219
xref: PTHR45627:SF7
organism: Bos taurus

SNARE Complex s56 sa34 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

G protein subunit alpha i1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F1P977 90
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot A4IFL6 25
organism: Bos taurus

uniprot F7F580 47
type: UnificationXref
id: F7F580
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RBE7 31
xref: PTHR13809:SF1
organism: Canis lupus familiaris

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot Q08462 253
organism: Homo sapiens

Mus musculus
type: BioSource
xref: ncbitaxon 10090 19

PRKACB isoform 3
type: ProteinReference
xref: uniprot H2R1G3 144
xref: PTHR24353:SF116
organism: Pan troglodytes

uniprot P43425 61
type: UnificationXref
id: P43425
db: uniprot

Adenylate cyclase type 1
type: ProteinReference
xref: PTHR45627:SF12
xref: uniprot P19754 240
organism: Bos taurus

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P17612 159
xref: PTHR24353:SF82
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: PTHR19850:SF27
xref: uniprot P62879 206
organism: Homo sapiens

Gbeta s68 sa50 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 205
xref: PTHR19850:SF29
organism: Mus musculus

GABA-B receptor/ GABA/ G protein complex
type: Complex
component stoichiometry: Gbeta s74 sa55 STOICHIOMETRY ID COMPLEX
component stoichiometry: GABA B receptor s71 sa52 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gi oalpha s75 sa56 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s73 sa54 STOICHIOMETRY ID COMPLEX
component stoichiometry: GABA s72 sa53 STOICHIOMETRY ID COMPLEX
component: Ggamma
component: GABA-B receptor
component: Gi/oalpha
component: Gbeta
component: GABA
feature: COMPLEX BINDING FEATURE s70 csa9 294
feature: COMPLEX BINDING FEATURE s70 csa9 296
feature: COMPLEX BINDING FEATURE s70 csa9 298
feature: COMPLEX BINDING FEATURE s70 csa9 290
feature: COMPLEX BINDING FEATURE s70 csa9 292
cellular location: axon terminus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 203
xref: PTHR19850:SF29
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 204
xref: PTHR19850:SF29
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 207
xref: PTHR19850:SF27
organism: Mus musculus

Ca2 PLUS s55 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Protein kinase cAMP-activated catalytic subunit beta
type: ProteinReference
xref: uniprot F6T0T9 137
xref: PTHR24353:SF116
organism: Xenopus tropicalis

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF1
xref: uniprot A0A2I3SK46 216
organism: Pan troglodytes

Gi oalpha s9 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gi/oalpha
stoichiometric coefficient: 1.0

uniprot F6T0T9 137
type: UnificationXref
id: F6T0T9
db: uniprot

uniprot F7HUD3 231
type: UnificationXref
id: F7HUD3
db: uniprot

PRKAR1A isoform 12
type: ProteinReference
xref: uniprot H2R3M7 145
xref: PTHR11635:SF129
organism: Pan troglodytes

Gnai3 protein
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot A9JTC8 87
organism: Danio rerio

uniprot E2RJB3 33
type: UnificationXref
id: E2RJB3
db: uniprot

Potassium channel, inwardly rectifying subfamily J, member 3
type: ProteinReference
xref: PTHR11767:SF16
xref: uniprot F6R882 110
organism: Xenopus tropicalis

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 202
xref: PTHR19850:SF29
organism: Bos taurus

Adenylate cyclase
type: ProteinReference
xref: uniprot F1LQT1 224
xref: PTHR45627:SF9
organism: Rattus norvegicus

uniprot H2QUY0 55
type: UnificationXref
id: H2QUY0
db: uniprot

Adenylate cyclase type 9
type: ProteinReference
xref: PTHR45627:SF8
xref: uniprot O60503 237
organism: Homo sapiens

P05753
type: UnificationXref
id: P05753
db: PANTHER Pathway Component

P05754
type: UnificationXref
id: P05754
db: PANTHER Pathway Component

P05755
type: UnificationXref
id: P05755
db: PANTHER Pathway Component

P05756
type: UnificationXref
id: P05756
db: PANTHER Pathway Component

P05752
type: UnificationXref
id: P05752
db: PANTHER Pathway Component

GABA
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa5 283
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot F7CTP1 190
xref: PTHR19850:SF31
organism: Macaca mulatta

GABA
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s72 sa53 293
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot E1BQ12 221
type: UnificationXref
id: E1BQ12
db: uniprot

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: uniprot F7ERG6 112
xref: PTHR11767:SF16
organism: Macaca mulatta

uniprot Q5I0F6 175
type: UnificationXref
id: Q5I0F6
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 52

uniprot P16520 198
type: UnificationXref
id: P16520
db: uniprot

ADCY9 isoform 1
type: ProteinReference
xref: PTHR45627:SF8
xref: uniprot K7CYN2 235
organism: Pan troglodytes

Adenylate cyclase type 4
type: ProteinReference
xref: PTHR45627:SF10
xref: uniprot Q91WF3 258
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P68182 171
xref: PTHR24353:SF116
organism: Rattus norvegicus

eco ECO:0000245 58
type: UnificationXref
id: ECO:0000245
db: eco

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P68181 170
xref: PTHR24353:SF116
organism: Mus musculus

ncbitaxon 10090 19
type: UnificationXref
id: 10090
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: PTHR13809:SF1
xref: uniprot Q5E9F0 77
organism: Bos taurus

axon terminus
type: CellularLocationVocabulary
xref: GO GO:0043679 2

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF10
xref: uniprot H2Q832 232
organism: Pan troglodytes

uniprot F1P977 90
type: UnificationXref
id: F1P977
db: uniprot

uniprot P62872 203
type: UnificationXref
id: P62872
db: uniprot

uniprot G3V8K2 50
type: UnificationXref
id: G3V8K2
db: uniprot

uniprot P51830 247
type: UnificationXref
id: P51830
db: uniprot

Gbetagamma complex
type: Complex
component stoichiometry: Gbeta s81 sa59 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s82 sa60 STOICHIOMETRY ID COMPLEX
component: Gbeta
component: Ggamma
feature: COMPLEX BINDING FEATURE s80 csa11 306
feature: COMPLEX BINDING FEATURE s80 csa11 304
cellular location: axon terminus

Gamma-aminobutyric acid type B receptor subunit 2
type: ProteinReference
xref: PTHR10519:SF67
xref: uniprot Q80T41 125
organism: Mus musculus

GABA B receptor s66 sa48 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GABA-B receptor
stoichiometric coefficient: 1.0

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: uniprot P97445 20
xref: PTHR45628:SF3
organism: Mus musculus

uniprot P19754 240
type: UnificationXref
id: P19754
db: uniprot

Gi/oalpha
type: ProteinReference
xref: P05757
standard name: G-protein (i/o), alpha subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=GABA-B_receptor_II_signaling.PROTEIN.GENERIC.G_sub_i_slash_o_endsub__alpha_
comment: ENTITY_REFERENCE_NOTES=Long Name: Gi/oalpha Synonym: Synonym not specified Accession: P05757
member entity reference: Guanine nucleotide-binding protein G(k) subunit alpha
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1
member entity reference: G protein subunit alpha i1
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
member entity reference: Gnai3 protein
member entity reference: G protein subunit alpha o1
member entity reference: Guanine nucleotide-binding protein G(K) subunit alpha
member entity reference: G protein subunit alpha i3
member entity reference: Guanine nucleotide-binding protein G(o) subunit alpha
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
member entity reference: Guanine nucleotide-binding protein G(O) subunit alpha isoform a

uniprot F6XWE8 41
type: UnificationXref
id: F6XWE8
db: uniprot

uniprot P31324 167
type: UnificationXref
id: P31324
db: uniprot

Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
type: ProteinReference
xref: uniprot F1QEC8 133
xref: PTHR11635:SF129
organism: Danio rerio

Neurotransmitter
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 186
xref: PTHR19850:SF29
organism: Ornithorhynchus anatinus

Gi/oalpha
type: Protein
entity reference: Gi/oalpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s75 sa56 299
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot P61952 65
type: UnificationXref
id: P61952
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF1
xref: uniprot E1BQ12 221
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot F6RIM7 91
organism: Monodelphis domestica

uniprot P51829 246
type: UnificationXref
id: P51829
db: uniprot

ncbitaxon 9913 5
type: UnificationXref
id: 9913
db: ncbitaxon

GABA-B receptor
type: Protein
entity reference: GABA-B receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s79 sa58 315
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

G protein subunit beta 4
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot E2R2S8 185
organism: Canis lupus familiaris

uniprot F7FXA9 193
type: UnificationXref
id: F7FXA9
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF1
xref: uniprot F7BCI5 227
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R2S3 29
xref: PTHR13809:SF8
organism: Canis lupus familiaris

Gbetagamma complex
type: Complex
component stoichiometry: Gbeta s25 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s26 sa14 STOICHIOMETRY ID COMPLEX
component: Gbeta
component: Ggamma
feature: COMPLEX BINDING FEATURE s27 csa3 302
feature: COMPLEX BINDING FEATURE s27 csa3 300
cellular location: axon terminus

Adenylate cyclase type 9
type: ProteinReference
xref: PTHR45627:SF8
xref: uniprot Q9DGG6 259
organism: Gallus gallus

MODULATION
type: RelationshipTypeVocabulary

Adenylate cyclase
type: ProteinReference
xref: uniprot D4A3N4 217
xref: PTHR45627:SF12
organism: Rattus norvegicus

uniprot Q08C49 172
type: UnificationXref
id: Q08C49
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 10

uniprot F6R7N8 136
type: UnificationXref
id: F6R7N8
db: uniprot

uniprot Q9DGG6 259
type: UnificationXref
id: Q9DGG6
db: uniprot

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
type: ProteinReference
xref: PTHR24353:SF135
xref: uniprot Q6DBV8 177
organism: Danio rerio

uniprot A3KMS9 130
type: UnificationXref
id: A3KMS9
db: uniprot

GABA
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa16 311
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A9JTC8 87
type: UnificationXref
id: A9JTC8
db: uniprot

Potassium voltage-gated channel subfamily J member 3
type: ProteinReference
xref: PTHR11767:SF16
xref: uniprot F6WTY3 111
organism: Ornithorhynchus anatinus

uniprot P22694 161
type: UnificationXref
id: P22694
db: uniprot

PTHR19850:SF27
type: RelationshipXref
id: PTHR19850:SF27
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re19 337
type: Stoichiometry
physical entity: GABA-B receptor/ GABA/ G protein complex
stoichiometric coefficient: 1.0

Protein kinase cAMP-dependent type II regulatory subunit alpha
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot E2RRD1 132
organism: Canis lupus familiaris

uniprot F2Z3T8 36
type: UnificationXref
id: F2Z3T8
db: uniprot

PARTICIPANT STOICHIOMETRY re19 336
type: Stoichiometry
physical entity: GABA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 335
type: Stoichiometry
physical entity: GABA-B receptor/ G protein complex
stoichiometric coefficient: 1.0

uniprot P63250 115
type: UnificationXref
id: P63250
db: uniprot

uniprot P08754 98
type: UnificationXref
id: P08754
db: uniprot

Protein kinase cAMP-dependent type I regulatory subunit alpha
type: ProteinReference
xref: uniprot F6R7N8 136
xref: PTHR11635:SF129
organism: Monodelphis domestica

uniprot Q3KRE3 76
type: UnificationXref
id: Q3KRE3
db: uniprot

Adenylate cyclase type 8
type: ProteinReference
xref: PTHR45627:SF1
xref: uniprot P97490 249
organism: Mus musculus

uniprot Q5BJ11 208
type: UnificationXref
id: Q5BJ11
db: uniprot

DISSOCIATION
type: RelationshipTypeVocabulary

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot Q9DC51 108
organism: Mus musculus

PTHR19850:SF29
type: RelationshipXref
id: PTHR19850:SF29
db: PANTHER Family
relationship type: By Homology

PTHR19850:SF28
type: RelationshipXref
id: PTHR19850:SF28
db: PANTHER Family
relationship type: By Homology

Gbeta
type: ProteinReference
xref: P05755
standard name: G protein, beta subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=GABA-B_receptor_II_signaling.PROTEIN.GENERIC.G_beta_
comment: ENTITY_REFERENCE_NOTES= Long Name: Gbeta Synonym: Synonym not specified Accession: P05755
member entity reference: G protein subunit beta 2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: G protein subunit beta 1
member entity reference: GNB4 protein
member entity reference: G protein subunit beta 4
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: G protein subunit beta 3
member entity reference: Guanine nucleotide-binding protein subunit beta-4
member entity reference: Gnb2 protein
member entity reference: Gnb1l protein

uniprot A0A2I3SK46 216
type: UnificationXref
id: A0A2I3SK46
db: uniprot

Gbeta s81 sa59 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot P50150 62
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot P50154 64
xref: PTHR13809:SF28
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot P50153 63
organism: Mus musculus

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P50146 101
organism: Gallus gallus

Gi oalpha s21 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gi/oalpha
stoichiometric coefficient: 1.0

uniprot F6Y3N2 188
type: UnificationXref
id: F6Y3N2
db: uniprot

GABA s38 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GABA
stoichiometric coefficient: 1.0

uniprot P97490 249
type: UnificationXref
id: P97490
db: uniprot

uniprot F7A472 94
type: UnificationXref
id: F7A472
db: uniprot

K channel
type: ProteinReference
xref: P05758
standard name: Inwardly rectifying potassium channel Kir3.1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=GABA-B_receptor_II_signaling.PROTEIN.ION_CHANNEL.K channel
comment: ENTITY_REFERENCE_NOTES=Long Name: Inwardly rectifying potassium channel Kir3.1 Synonym: GIRK1,KCNJ3 Accession: P05758
member entity reference: G protein-activated inward rectifier potassium channel 1
member entity reference: KCNJ3 isoform 1
member entity reference: Potassium channel, inwardly rectifying subfamily J, member 3
member entity reference: Potassium voltage-gated channel subfamily J member 3

uniprot Q80TL1 256
type: UnificationXref
id: Q80TL1
db: uniprot

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF126
xref: uniprot P12849 157
organism: Mus musculus

uniprot P97445 20
type: UnificationXref
id: P97445
db: uniprot

uniprot O95622 239
type: UnificationXref
id: O95622
db: uniprot

uniprot P63218 74
type: UnificationXref
id: P63218
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P27791 162
xref: PTHR24353:SF82
organism: Rattus norvegicus

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: PTHR45628:SF3
xref: uniprot O00555 12
organism: Homo sapiens

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot Q00975 21
type: UnificationXref
id: Q00975
db: uniprot

uniprot P34099 168
type: UnificationXref
id: P34099
db: uniprot

PTHR10218:SF302
type: RelationshipXref
id: PTHR10218:SF302
db: PANTHER Family
relationship type: By Homology

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot K7ADQ0 234
organism: Pan troglodytes

KCNJ3 isoform 1
type: ProteinReference
xref: uniprot H2QIU3 113
xref: PTHR11767:SF16
organism: Pan troglodytes

uniprot F6UJE8 92
type: UnificationXref
id: F6UJE8
db: uniprot

uniprot F7BB02 44
type: UnificationXref
id: F7BB02
db: uniprot

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa9 285
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot F6WM87 138
xref: PTHR11635:SF129
organism: Macaca mulatta

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re6
control type: ACTIVATION
controller: Ca channel

GABA-B receptor
type: Protein
entity reference: GABA-B receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa15 309
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

PTHR19850:SF31
type: RelationshipXref
id: PTHR19850:SF31
db: PANTHER Family
relationship type: By Homology

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: PTHR11767:SF16
xref: uniprot P63250 115
organism: Mus musculus

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: PTHR11767:SF16
xref: uniprot P63251 116
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION_LEFT__Ca2_PLUS_-_SNARE_Complex-RIGHT__Complex__SNARE_Complex_Ca2_PLUS__-_re17
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 344
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 345
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 346
left: SNARE Complex
left: Ca2+
interaction type: HETERODIMER_ASSOCIATION
right: Complex (SNARE Complex/Ca2+)

uniprot Q9UBS5 126
type: UnificationXref
id: Q9UBS5
db: uniprot

uniprot Q7T3D3 106
type: UnificationXref
id: Q7T3D3
db: uniprot

Prkar1a protein
type: ProteinReference
xref: uniprot Q5I0F6 175
xref: PTHR11635:SF129
organism: Danio rerio

HETERODIMER_ASSOCIATION_LEFT__GABA_B_receptor__G_protein_complex-_GABA-RIGHT__GABA_B_receptor__GABA__G_protein_complex-_re19
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 336
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 335
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 337
left: GABA-B receptor/ G protein complex
left: GABA
interaction type: HETERODIMER_ASSOCIATION
right: GABA-B receptor/ GABA/ G protein complex

Voltage-dependent T-type calcium channel subunit alpha-1G
type: ProteinReference
xref: PTHR10037:SF137
xref: uniprot O43497 14
organism: Homo sapiens

PTHR13809:SF1
type: RelationshipXref
id: PTHR13809:SF1
db: PANTHER Family
relationship type: By Homology

PTHR13809:SF5
type: RelationshipXref
id: PTHR13809:SF5
db: PANTHER Family
relationship type: By Homology

DISSOCIATION_LEFT__GABA_B_receptor__GABA__G_protein_complex-RIGHT__Gbetagamma_complex-_GABA_B_receptor__GABA_complex-_Gi_oalpha-_re20
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 338
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 339
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 341
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 340
left: GABA-B receptor/ GABA/ G protein complex
interaction type: DISSOCIATION
right: Gbetagamma complex
right: Gi/oalpha
right: GABA-B receptor/ GABA complex

uniprot A0A3Q1NGS8 182
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

Gi oalpha s67 sa49 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gi/oalpha
stoichiometric coefficient: 1.0

uniprot F6Q9S4 135
type: UnificationXref
id: F6Q9S4
db: uniprot

uniprot O75899 122
type: UnificationXref
id: O75899
db: uniprot

uniprot Q08828 254
type: UnificationXref
id: Q08828
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re7
control type: INHIBITION
controller: Gi/oalpha

SNARE Complex
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s54 sa42 277
feature: SNARE Complex s54 sa42 rs1
feature: ACTIVE 24
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot P63219 75
organism: Rattus norvegicus

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot F6Q503 134
xref: PTHR11635:SF156
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 74
xref: PTHR13809:SF5
organism: Homo sapiens

eco ECO:0000304 15
type: UnificationXref
id: ECO:0000304
db: eco

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot P63217 73
organism: Bos taurus

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot P63216 72
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 71
xref: PTHR13809:SF11
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63214 70
xref: PTHR13809:SF11
organism: Bos taurus

uniprot F6ZAV4 226
type: UnificationXref
id: F6ZAV4
db: uniprot

uniprot E2R2S8 185
type: UnificationXref
id: E2R2S8
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 164

Gi/oalpha
type: Protein
entity reference: Gi/oalpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s67 sa49 271
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

G protein subunit alpha i1
type: ProteinReference
xref: uniprot A0A2I3S4R3 85
xref: PTHR10218:SF227
organism: Pan troglodytes

uniprot A5PKD6 183
type: UnificationXref
id: A5PKD6
db: uniprot

uniprot Q03343 251
type: UnificationXref
id: Q03343
db: uniprot

uniprot F6VL43 93
type: UnificationXref
id: F6VL43
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot F7F580 47
organism: Macaca mulatta

G protein subunit alpha o1
type: ProteinReference
xref: uniprot A0A2I3TFM8 86
xref: PTHR10218:SF302
organism: Pan troglodytes

Gbeta s13 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot Q9CXP8 81
organism: Mus musculus

uniprot Q90854 117
type: UnificationXref
id: Q90854
db: uniprot

PKA
type: Protein
entity reference: PKA
feature: ACTIVE 24
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s55 sa43 279
cellular location: synaptic vesicle
comment: SPECIES_TYPE=ION

Adenylate cyclase type 1
type: ProteinReference
xref: PTHR45627:SF12
xref: uniprot O88444 238
organism: Mus musculus

uniprot P30804 242
type: UnificationXref
id: P30804
db: uniprot

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P59215 102
organism: Rattus norvegicus

GABA-B receptor
type: Protein
entity reference: GABA-B receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa2 261
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot E2RGI5 32
organism: Canis lupus familiaris

uniprot P18872 100
type: UnificationXref
id: P18872
db: uniprot

K channel
type: Protein
entity reference: K channel
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

TRANSPORT
type: RelationshipTypeVocabulary

Adenylate cyclase type 6
type: ProteinReference
xref: uniprot Q03343 251
xref: PTHR45627:SF11
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P18872 100
organism: Mus musculus

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 58

ACTIVE 24
type: EntityFeature
comment: Active state

PTHR24353:SF137
type: RelationshipXref
id: PTHR24353:SF137
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF135
type: RelationshipXref
id: PTHR24353:SF135
db: PANTHER Family
relationship type: By Homology

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa14 303
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

PKA
type: Protein
entity reference: PKA
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Ca_channel-RIGHT__Ca_channel-_re5
control type: INHIBITION
controller: Gbetagamma complex

neuronal function
type: Pathway

uniprot P59215 102
type: UnificationXref
id: P59215
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot H2Q1D9 53
organism: Pan troglodytes

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot P52287 199
organism: Rattus norvegicus

Voltage-dependent T-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR45628:SF15
xref: uniprot F1MR37 4
organism: Bos taurus

uniprot Q9DC51 108
type: UnificationXref
id: Q9DC51
db: uniprot

uniprot Q9DBC7 180
type: UnificationXref
id: Q9DBC7
db: uniprot

GABA-B receptor/ GABA/ G protein complex
type: Complex
component stoichiometry: Gbeta s13 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: GABA s37 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s14 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: GABA B receptor s12 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gi oalpha s9 sa11 STOICHIOMETRY ID COMPLEX
component: GABA
component: Ggamma
component: Gi/oalpha
component: Gbeta
component: GABA-B receptor
feature: COMPLEX BINDING FEATURE s33 csa1 282
feature: COMPLEX BINDING FEATURE s33 csa1 286
feature: COMPLEX BINDING FEATURE s33 csa1 280
feature: COMPLEX BINDING FEATURE s33 csa1 284
feature: COMPLEX BINDING FEATURE s33 csa1 288
cellular location: axon terminus

uniprot Q8NFM4 257
type: UnificationXref
id: Q8NFM4
db: uniprot

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot P00514 148
organism: Bos taurus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P00515 149
organism: Bos taurus

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P00517 150
xref: PTHR24353:SF82
organism: Bos taurus

ncbitaxon 13616 42
type: UnificationXref
id: 13616
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re22 331
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re22 332
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

uniprot Q6DBV8 177
type: UnificationXref
id: Q6DBV8
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 42

uniprot F7CXD0 191
type: UnificationXref
id: F7CXD0
db: uniprot

uniprot B2RSH2 89
type: UnificationXref
id: B2RSH2
db: uniprot

uniprot Q61016 78
type: UnificationXref
id: Q61016
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot E1BW98 184
organism: Gallus gallus

uniprot E2RGI5 32
type: UnificationXref
id: E2RGI5
db: uniprot

uniprot P31323 166
type: UnificationXref
id: P31323
db: uniprot

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: PTHR45628:SF6
xref: uniprot O55017 18
organism: Mus musculus

PTHR13809:SF6
type: RelationshipXref
id: PTHR13809:SF6
db: PANTHER Family
relationship type: By Homology

PTHR13809:SF8
type: RelationshipXref
id: PTHR13809:SF8
db: PANTHER Family
relationship type: By Homology

uniprot P61953 66
type: UnificationXref
id: P61953
db: uniprot

uniprot P51828 245
type: UnificationXref
id: P51828
db: uniprot

PTHR24353:SF116
type: RelationshipXref
id: PTHR24353:SF116
db: PANTHER Family
relationship type: By Homology

uniprot A4IGZ2 26
type: UnificationXref
id: A4IGZ2
db: uniprot

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
type: ProteinReference
xref: uniprot A3KMS9 130
xref: PTHR24353:SF82
organism: Danio rerio

uniprot Q3ZB92 173
type: UnificationXref
id: Q3ZB92
db: uniprot

GABA s72 sa53 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GABA
stoichiometric coefficient: 1.0

GABA
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s78 sa57 313
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot B2RSH2 89
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot F7G3J2 194
organism: Monodelphis domestica

uniprot F7GI54 49
type: UnificationXref
id: F7GI54
db: uniprot

uniprot F7E427 192
type: UnificationXref
id: F7E427
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot A0A1D5RHE7 215
organism: Macaca mulatta

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot P08754 98
organism: Homo sapiens

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot P08753 97
xref: PTHR10218:SF230
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(K) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot F6VL43 93
organism: Macaca mulatta

GABA B receptor s29 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GABA-B receptor
stoichiometric coefficient: 1.0

Adenylate cyclase type 5
type: ProteinReference
xref: uniprot P84309 248
xref: PTHR45627:SF7
organism: Mus musculus

uniprot F6V001 225
type: UnificationXref
id: F6V001
db: uniprot

uniprot E1BM79 220
type: UnificationXref
id: E1BM79
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P05132 152
xref: PTHR24353:SF82
organism: Mus musculus

uniprot Q9WV18 127
type: UnificationXref
id: Q9WV18
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P05131 151
organism: Bos taurus

uniprot A4IFL6 25
type: UnificationXref
id: A4IFL6
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot Q9HAV0 212
organism: Homo sapiens

Adenylate cyclase type 1
type: ProteinReference
xref: uniprot Q08828 254
xref: PTHR45627:SF12
organism: Homo sapiens

uniprot P63077 68
type: UnificationXref
id: P63077
db: uniprot

uniprot P09471 99
type: UnificationXref
id: P09471
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RJB3 33
xref: PTHR13809:SF11
organism: Canis lupus familiaris

GABA B receptor s71 sa52 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GABA-B receptor
stoichiometric coefficient: 1.0

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF12
xref: uniprot H2QUJ4 233
organism: Pan troglodytes

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot E2RRA1 131
xref: PTHR11635:SF156
organism: Canis lupus familiaris

uniprot P05131 151
type: UnificationXref
id: P05131
db: uniprot

uniprot Q803H5 211
type: UnificationXref
id: Q803H5
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1PJE5 35
xref: PTHR13809:SF19
organism: Canis lupus familiaris

G protein subunit gamma 5
type: ProteinReference
xref: PTHR13809:SF51
xref: uniprot H2PZA6 51
organism: Pan troglodytes

GABA-B receptor
type: Protein
entity reference: GABA-B receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s71 sa52 291
feature: ACTIVE 24
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__GABA-_GABA_B_receptor__G_protein_complex-RIGHT__GABA_B_receptor__GABA__G_protein_complex-_re3
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 330
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 329
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 328
left: GABA
left: GABA-B receptor/ G protein complex
interaction type: HETERODIMER_ASSOCIATION
right: GABA-B receptor/ GABA/ G protein complex

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot Q9UK08 82
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re7 319
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 318
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: PTHR45628:SF6
xref: uniprot Q00975 21
organism: Homo sapiens

Danio rerio
type: BioSource
xref: ncbitaxon 7955 88

GABBR2 isoform 1
type: ProteinReference
xref: PTHR10519:SF67
xref: uniprot H2R3Y0 121
organism: Pan troglodytes

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot Q8MJ44 178
xref: PTHR24353:SF82
organism: Canis lupus familiaris

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: uniprot P13861 158
xref: PTHR11635:SF153
organism: Homo sapiens

Gamma-aminobutyric acid type B receptor subunit 1
type: ProteinReference
xref: PTHR10519:SF42
xref: uniprot Q9UBS5 126
organism: Homo sapiens

uniprot P00514 148
type: UnificationXref
id: P00514
db: uniprot

uniprot Q5BK52 174
type: UnificationXref
id: Q5BK52
db: uniprot

K channel
type: Protein
entity reference: K channel
feature: ACTIVE 24
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 181
xref: PTHR19850:SF27
organism: Pan troglodytes

PTHR10519:SF67
type: RelationshipXref
id: PTHR10519:SF67
db: PANTHER Family
relationship type: By Homology

uniprot F7H582 230
type: UnificationXref
id: F7H582
db: uniprot

uniprot F1QEC8 133
type: UnificationXref
id: F1QEC8
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot F6YZA3 43
organism: Monodelphis domestica

PTHR10037:SF290
type: RelationshipXref
id: PTHR10037:SF290
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re17 344
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 345
type: Stoichiometry
physical entity: SNARE Complex
stoichiometric coefficient: 1.0

uniprot K7AEL3 147
type: UnificationXref
id: K7AEL3
db: uniprot

PTHR45627:SF11
type: RelationshipXref
id: PTHR45627:SF11
db: PANTHER Family
relationship type: By Homology

uniprot O88444 238
type: UnificationXref
id: O88444
db: uniprot

PTHR45627:SF10
type: RelationshipXref
id: PTHR45627:SF10
db: PANTHER Family
relationship type: By Homology

uniprot P63214 70
type: UnificationXref
id: P63214
db: uniprot

PTHR45627:SF12
type: RelationshipXref
id: PTHR45627:SF12
db: PANTHER Family
relationship type: By Homology

Gamma-aminobutyric acid type B receptor subunit 1
type: ProteinReference
xref: uniprot Q9WV18 127
xref: PTHR10519:SF42
organism: Mus musculus

uniprot P48549 114
type: UnificationXref
id: P48549
db: uniprot

uniprot Q5SUF7 23
type: UnificationXref
id: Q5SUF7
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P63097 104
organism: Bos taurus

uniprot E1B9K3 218
type: UnificationXref
id: E1B9K3
db: uniprot

uniprot P12369 156
type: UnificationXref
id: P12369
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P63096 103
organism: Homo sapiens

uniprot P84309 248
type: UnificationXref
id: P84309
db: uniprot

PARTICIPANT STOICHIOMETRY re17 346
type: Stoichiometry
physical entity: Complex (SNARE Complex/Ca2+)
stoichiometric coefficient: 1.0

ncbitaxon 9258 39
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot F7G7I9 48
type: UnificationXref
id: F7G7I9
db: uniprot

Ggamma s23 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Neurotransmitter-RIGHT__Neurotransmitter-_re18
control type: ACTIVATION
controller: Complex (SNARE Complex/Ca2+)

uniprot P68181 170
type: UnificationXref
id: P68181
db: uniprot

PTHR10519:SF42
type: RelationshipXref
id: PTHR10519:SF42
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot F6TFY2 37
organism: Macaca mulatta

ncbitaxon 9606 13
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot Q61017 79
type: UnificationXref
id: Q61017
db: uniprot

Voltage-dependent T-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot Q5SUF7 23
xref: PTHR10037:SF137
organism: Mus musculus

GABA B receptor s79 sa58 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GABA-B receptor
stoichiometric coefficient: 1.0

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 17

PTHR10037:SF289
type: RelationshipXref
id: PTHR10037:SF289
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re3 328
type: Stoichiometry
physical entity: GABA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 329
type: Stoichiometry
physical entity: GABA-B receptor/ G protein complex
stoichiometric coefficient: 1.0

uniprot Q3ZCA7 105
type: UnificationXref
id: Q3ZCA7
db: uniprot

DISSOCIATION_LEFT__GABA_B_receptor__GABA__G_protein_complex-RIGHT__GABA_B_receptor__GABA_complex-_Gi_oalpha-_Gbetagamma_complex-_re4
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 327
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 325
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 324
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 326
left: GABA-B receptor/ GABA/ G protein complex
interaction type: DISSOCIATION
right: Gbetagamma complex
right: Gi/oalpha
right: GABA-B receptor/ GABA complex

INHIBITION
type: RelationshipTypeVocabulary

uniprot F6V461 38
type: UnificationXref
id: F6V461
db: uniprot

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot Q9DBC7 180
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63078 69
xref: PTHR13809:SF19
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 68
xref: PTHR13809:SF19
organism: Rattus norvegicus

uniprot A0A2I3TUD1 181
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P09471 99
organism: Homo sapiens

uniprot H2RER5 146
type: UnificationXref
id: H2RER5
db: uniprot

uniprot F6PVT7 187
type: UnificationXref
id: F6PVT7
db: uniprot

uniprot P50146 101
type: UnificationXref
id: P50146
db: uniprot

P05760
type: UnificationXref
id: P05760
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re21 333
type: Stoichiometry
physical entity: K channel
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re21 334
type: Stoichiometry
physical entity: K channel
stoichiometric coefficient: 1.0

uniprot F6Q503 134
type: UnificationXref
id: F6Q503
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 201
xref: PTHR19850:SF27
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 200
xref: PTHR19850:SF29
organism: Rattus norvegicus

Ggamma s69 sa51 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

uniprot H2R1G3 144
type: UnificationXref
id: H2R1G3
db: uniprot

P05757
type: UnificationXref
id: P05757
db: PANTHER Pathway Component

P05758
type: UnificationXref
id: P05758
db: PANTHER Pathway Component

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s74 sa55 297
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

G protein subunit beta 4
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot F7E427 192
organism: Ornithorhynchus anatinus

Adenylate cyclase
type: ProteinReference
xref: uniprot F6V001 225
xref: PTHR45627:SF6
organism: Monodelphis domestica

uniprot E2R2S3 29
type: UnificationXref
id: E2R2S3
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: uniprot Q7T3D3 106
xref: PTHR10218:SF227
organism: Danio rerio

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot Q6PH57 210
organism: Danio rerio

PANTHER Pathway P05731 1
type: UnificationXref
id: P05731
db: PANTHER Pathway

Target ion channel
type: Pathway

uniprot Q91WF3 258
type: UnificationXref
id: Q91WF3
db: uniprot

uniprot P50153 63
type: UnificationXref
id: P50153
db: uniprot

uniprot P52287 199
type: UnificationXref
id: P52287
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re22
control type: ACTIVATION
controller: K channel

Gbeta s74 sa55 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

uniprot O55017 18
type: UnificationXref
id: O55017
db: uniprot

uniprot H2Q3W7 54
type: UnificationXref
id: H2Q3W7
db: uniprot

uniprot P54311 200
type: UnificationXref
id: P54311
db: uniprot

PARTICIPANT STOICHIOMETRY re20 341
type: Stoichiometry
physical entity: Gi/oalpha
stoichiometric coefficient: 1.0

GABA-B_receptor_II_signaling
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__Ca2_PLUS_-_SNARE_Complex-RIGHT__Complex__SNARE_Complex_Ca2_PLUS__-_re17
pathway component: STATE_TRANSITION_LEFT__K_channel-RIGHT__K_channel-_re21
pathway component: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re7
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re6
pathway component: DISSOCIATION_LEFT__GABA_B_receptor__GABA__G_protein_complex-RIGHT__GABA_B_receptor__GABA_complex-_Gi_oalpha-_Gbetagamma_complex-_re4
pathway component: HETERODIMER_ASSOCIATION_LEFT__GABA-_GABA_B_receptor__G_protein_complex-RIGHT__GABA_B_receptor__GABA__G_protein_complex-_re3
pathway component: HETERODIMER_ASSOCIATION_LEFT__GABA_B_receptor__G_protein_complex-_GABA-RIGHT__GABA_B_receptor__GABA__G_protein_complex-_re19
pathway component: MODULATION
pathway component: TRANSPORT_LEFT__Neurotransmitter-RIGHT__Neurotransmitter-_re18
pathway component: DISSOCIATION_LEFT__GABA_B_receptor__GABA__G_protein_complex-RIGHT__Gbetagamma_complex-_GABA_B_receptor__GABA_complex-_Gi_oalpha-_re20
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re8
pathway component: STATE_TRANSITION_LEFT__Ca_channel-RIGHT__Ca_channel-_re5
pathway component: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re22
xref: PANTHER Pathway P05731 1
comment: MODEL_NOTES=Panther Pathway: P05731 GABA (gamma-aminobutyric acid) is the major inhibitory neurotransmitter in the central nervous system. It mediates its action through the ionotropic GABA-A and GABA-B receptors. GABA-A receptors form ion channels, while GABA-B receptors are G-protein coupled receptors. This pathway focuses on signaling pathway mediated by GABA-B receptor. GABA-B receptor are located on both presynaptic and postsynaptic membrane. Presynaptic GABA-B receptors are subdivided into autoreceptors that control GABA release, and heteroreceptors that inhibits all other neurotransmitter release. Upon binding to GABA, the presynaptic GABA-B receptor decreases Ca ion influx by inhibiting voltage-dependent Ca channels, particularly N-type and P/Q type, via beta and gamma subunit of G protein, thus lowering the presynaptic Ca concentration and decreasing neurotransmitter release. Postsynaptic GABA-B receptors induce a slow inhibitory postsynaptic current through the activation of an inward rectifying K channel (GIRK). In addition, recent studies found that synaptic plasticity can be controlled by the cAMP pathway. GABA-B receptors have been found to play a role in the field of substance abuse or addition. It has been reported that administration of GABA-B agonist, such as baclofen, can reduce patients' craving for cocaine or alcohol. Recently, an association study showed close linkage between several SNPs of GABA B2 receptor and nicotine dependency. Medline=11311380 Medline=16539894 OMIM=607340 PMID: 11311380 PMID: 16539894

PARTICIPANT STOICHIOMETRY re20 340
type: Stoichiometry
physical entity: GABA-B receptor/ GABA complex
stoichiometric coefficient: 1.0

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: PTHR11767:SF16
xref: uniprot E1BNE9 109
organism: Bos taurus

uniprot F6WM87 138
type: UnificationXref
id: F6WM87
db: uniprot

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot P34099 168
xref: PTHR24353:SF37
organism: Dictyostelium discoideum

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot P62873 204
type: UnificationXref
id: P62873
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot F6V461 38
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot P16520 198
organism: Homo sapiens

K+
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=ION

Protein kinase, cAMP-dependent, catalytic, beta
type: ProteinReference
xref: uniprot Q3ZB92 173
xref: PTHR24353:SF116
organism: Danio rerio

PARTICIPANT STOICHIOMETRY re20 339
type: Stoichiometry
physical entity: Gbetagamma complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re20 338
type: Stoichiometry
physical entity: GABA-B receptor/ GABA/ G protein complex
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 316
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 317
left: PKA
interaction type: STATE_TRANSITION
right: PKA

uniprot F1N1E0 8
type: UnificationXref
id: F1N1E0
db: uniprot

uniprot Q02294 22
type: UnificationXref
id: Q02294
db: uniprot

uniprot O14610 57
type: UnificationXref
id: O14610
db: uniprot

ncbitaxon 9615 30
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot F6RIM7 91
type: UnificationXref
id: F6RIM7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10519:SF42
xref: uniprot A0A1D5RFW3 118
organism: Macaca mulatta

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF1
xref: uniprot A0A1D5Q874 213
organism: Macaca mulatta

STATE_TRANSITION_LEFT__Ca_channel-RIGHT__Ca_channel-_re5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 322
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 323
left: Ca channel
interaction type: STATE_TRANSITION
right: Ca channel

uniprot A0A2I3TFM8 86
type: UnificationXref
id: A0A2I3TFM8
db: uniprot

uniprot Q5ZM91 176
type: UnificationXref
id: Q5ZM91
db: uniprot

Ca2+
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=ION

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot F7FXA9 193
organism: Macaca mulatta

uniprot A0A1D5Q874 213
type: UnificationXref
id: A0A1D5Q874
db: uniprot

Voltage-dependent T-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR10037:SF137
xref: uniprot F7GWW5 9
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re8
controller: AC

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 208
xref: PTHR19850:SF27
organism: Danio rerio

GO GO:0043679 2
type: UnificationXref
id: GO:0043679
db: GO

GABA s78 sa57 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GABA
stoichiometric coefficient: 1.0

uniprot K7E376 56
type: UnificationXref
id: K7E376
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 209
xref: PTHR19850:SF31
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re18 342
type: Stoichiometry
physical entity: Neurotransmitter
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re18 343
type: Stoichiometry
physical entity: Neurotransmitter
stoichiometric coefficient: 1.0

uniprot P00515 149
type: UnificationXref
id: P00515
db: uniprot

uniprot G3X7Z2 11
type: UnificationXref
id: G3X7Z2
db: uniprot

uniprot Q7ZW82 107
type: UnificationXref
id: Q7ZW82
db: uniprot

uniprot Q08462 253
type: UnificationXref
id: Q08462
db: uniprot

Ca channel
type: Protein
entity reference: Ca channel
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot P40146 244
type: UnificationXref
id: P40146
db: uniprot

PARTICIPANT STOICHIOMETRY re3 330
type: Stoichiometry
physical entity: GABA-B receptor/ GABA/ G protein complex
stoichiometric coefficient: 1.0

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF1
xref: uniprot E2RCX6 223
organism: Canis lupus familiaris

uniprot P63096 103
type: UnificationXref
id: P63096
db: uniprot

PTHR10218:SF227
type: RelationshipXref
id: PTHR10218:SF227
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 78
xref: PTHR13809:SF8
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: PTHR13809:SF28
xref: uniprot Q61017 79
organism: Mus musculus

Ca channel
type: Protein
entity reference: Ca channel
feature: ACTIVE 24
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot P62879 206
type: UnificationXref
id: P62879
db: uniprot

Adenylate cyclase type 6
type: ProteinReference
xref: PTHR45627:SF11
xref: uniprot P30804 242
organism: Canis lupus familiaris

uniprot F1PJE5 35
type: UnificationXref
id: F1PJE5
db: uniprot

Ggamma s26 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s69 sa51 275
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot P11017 197
type: UnificationXref
id: P11017
db: uniprot

synaptic vesicle
type: CellularLocationVocabulary
xref: GO GO:0008021 3

PTHR10218:SF230
type: RelationshipXref
id: PTHR10218:SF230
db: PANTHER Family
relationship type: By Homology

Voltage-dependent P/Q-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot F1N1E0 8
xref: PTHR10037:SF290
organism: Bos taurus

Adenylate cyclase type 6
type: ProteinReference
xref: PTHR45627:SF11
xref: uniprot O43306 236
organism: Homo sapiens

uniprot P17612 159
type: UnificationXref
id: P17612
db: uniprot

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot P10644 153
organism: Homo sapiens

uniprot F7EBQ5 139
type: UnificationXref
id: F7EBQ5
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 27

uniprot P10644 153
type: UnificationXref
id: P10644
db: uniprot

ncbitaxon 7955 88
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot Q01341 250
type: UnificationXref
id: Q01341
db: uniprot

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q922R0 179
organism: Mus musculus

uniprot P31321 165
type: UnificationXref
id: P31321
db: uniprot

TRIGGER
type: RelationshipTypeVocabulary

uniprot H2PZA6 51
type: UnificationXref
id: H2PZA6
db: uniprot

uniprot P62871 202
type: UnificationXref
id: P62871
db: uniprot

ncbitaxon 8364 27
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot O60262 59
type: UnificationXref
id: O60262
db: uniprot

uniprot F7GWW5 9
type: UnificationXref
id: F7GWW5
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: PTHR13809:SF28
xref: uniprot O14610 57
organism: Homo sapiens

uniprot F1MYW8 34
type: UnificationXref
id: F1MYW8
db: uniprot

uniprot F6ZIZ9 189
type: UnificationXref
id: F6ZIZ9
db: uniprot

PARTICIPANT STOICHIOMETRY re6 321
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re6 320
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

GABA s37 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GABA
stoichiometric coefficient: 1.0

uniprot A0A1D5PCI4 129
type: UnificationXref
id: A0A1D5PCI4
db: uniprot

uniprot A0A1D5RHE7 215
type: UnificationXref
id: A0A1D5RHE7
db: uniprot

uniprot H2R3A6 196
type: UnificationXref
id: H2R3A6
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P30625 163
organism: Caenorhabditis elegans

MODULATION
type: Control
xref: MODULATION
controlled: neuronal function
controller: PKA

uniprot Q04400 252
type: UnificationXref
id: Q04400
db: uniprot

uniprot P30625 163
type: UnificationXref
id: P30625
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 197
xref: PTHR19850:SF27
organism: Bos taurus

uniprot P63215 71
type: UnificationXref
id: P63215
db: uniprot

Adenylate cyclase 9
type: ProteinReference
xref: PTHR45627:SF8
xref: uniprot F7CEX4 228
organism: Xenopus tropicalis

GABA-B receptor/ G protein complex
type: Complex
component stoichiometry: Ggamma s23 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s22 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: GABA B receptor s11 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gi oalpha s21 sa6 STOICHIOMETRY ID COMPLEX
component: Ggamma
component: Gbeta
component: Gi/oalpha
component: GABA-B receptor
feature: COMPLEX BINDING FEATURE s18 csa2 260
feature: COMPLEX BINDING FEATURE s18 csa2 262
feature: COMPLEX BINDING FEATURE s18 csa2 264
feature: COMPLEX BINDING FEATURE s18 csa2 266
cellular location: axon terminus

uniprot F6YZA3 43
type: UnificationXref
id: F6YZA3
db: uniprot

ncbitaxon 9544 10
type: UnificationXref
id: 9544
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QUY0 55
xref: PTHR13809:SF1
organism: Pan troglodytes

GABA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein G(O) subunit alpha isoform a
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot F7GQC5 95
organism: Macaca mulatta

uniprot P12367 154
type: UnificationXref
id: P12367
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P43425 61
xref: PTHR13809:SF8
organism: Rattus norvegicus

Protein kinase, X-linked
type: ProteinReference
xref: uniprot Q5BK52 174
xref: PTHR24353:SF37
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot A4IGZ2 26
organism: Xenopus tropicalis

GABA B receptor s11 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GABA-B receptor
stoichiometric coefficient: 1.0

ncbitaxon 10116 17
type: UnificationXref
id: 10116
db: ncbitaxon

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot Q5ZM91 176
organism: Gallus gallus

uniprot P63217 73
type: UnificationXref
id: P63217
db: uniprot

uniprot Q922R0 179
type: UnificationXref
id: Q922R0
db: uniprot

uniprot P63219 75
type: UnificationXref
id: P63219
db: uniprot

uniprot Q8MJ44 178
type: UnificationXref
id: Q8MJ44
db: uniprot

Protein kinase, cAMP-dependent, regulatory, type I, beta
type: ProteinReference
xref: PTHR11635:SF126
xref: uniprot Q08C49 172
organism: Danio rerio

PTHR13809:SF19
type: RelationshipXref
id: PTHR13809:SF19
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XWE8 41
xref: PTHR13809:SF8
organism: Monodelphis domestica

uniprot F7ERP8 45
type: UnificationXref
id: F7ERP8
db: uniprot

Neurotransmitter
type: SmallMolecule
cellular location: synaptic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR13809:SF11
type: RelationshipXref
id: PTHR13809:SF11
db: PANTHER Family
relationship type: By Homology

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re6
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 321
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 320
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

Adenylate cyclase type 4
type: ProteinReference
xref: PTHR45627:SF10
xref: uniprot Q8NFM4 257
organism: Homo sapiens

uniprot P63251 116
type: UnificationXref
id: P63251
db: uniprot

SNARE Complex s54 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SNARE Complex
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F6UJE8 92
organism: Monodelphis domestica

SNARE Complex
type: Protein
feature: SNARE Complex s56 sa34 rs1
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

Bos taurus
type: BioSource
xref: ncbitaxon 9913 5

Gamma-aminobutyric acid type B receptor subunit 1
type: ProteinReference
xref: uniprot Q9Z0U4 128
xref: PTHR10519:SF42
organism: Rattus norvegicus

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 39

PTHR13809:SF28
type: RelationshipXref
id: PTHR13809:SF28
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot H2Q3W7 54
organism: Pan troglodytes

TRANSPORT_LEFT__Neurotransmitter-RIGHT__Neurotransmitter-_re18
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 343
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 342
left: Neurotransmitter
interaction type: TRANSPORT
right: Neurotransmitter

Complex (SNARE Complex/Ca2+)
type: Complex
component stoichiometry: SNARE Complex s54 sa42 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ca2 PLUS s55 sa43 STOICHIOMETRY ID COMPLEX
component: Ca2+
component: SNARE Complex
feature: COMPLEX BINDING FEATURE s53 csa6 278
feature: COMPLEX BINDING FEATURE s53 csa6 276
cellular location: synaptic vesicle

uniprot Q9Z0U4 128
type: UnificationXref
id: Q9Z0U4
db: uniprot

PTHR13809:SF21
type: RelationshipXref
id: PTHR13809:SF21
db: PANTHER Family
relationship type: By Homology

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s82 sa60 307
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot D4A3N4 217
type: UnificationXref
id: D4A3N4
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P30671 60
xref: PTHR13809:SF8
organism: Bos taurus

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P31324 167
xref: PTHR11635:SF156
organism: Mus musculus

uniprot P12368 155
type: UnificationXref
id: P12368
db: uniprot

uniprot E2RRD1 132
type: UnificationXref
id: E2RRD1
db: uniprot

uniprot E2RBE7 31
type: UnificationXref
id: E2RBE7
db: uniprot

uniprot P08753 97
type: UnificationXref
id: P08753
db: uniprot

uniprot F6R882 110
type: UnificationXref
id: F6R882
db: uniprot

uniprot F7HAK5 141
type: UnificationXref
id: F7HAK5
db: uniprot

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa10 287
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 30

uniprot F7ERG6 112
type: UnificationXref
id: F7ERG6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NGS8 182
xref: PTHR19850:SF31
organism: Bos taurus

G protein subunit beta 4
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot H2QNS5 195
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7G7I9 48
xref: PTHR13809:SF11
organism: Ornithorhynchus anatinus

uniprot F1MR37 4
type: UnificationXref
id: F1MR37
db: uniprot

Gi oalpha s75 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gi/oalpha
stoichiometric coefficient: 1.0

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot Q80TL1 256
xref: PTHR45627:SF6
organism: Mus musculus

Adenylate cyclase type 9
type: ProteinReference
xref: uniprot P51830 247
xref: PTHR45627:SF8
organism: Mus musculus

uniprot P63097 104
type: UnificationXref
id: P63097
db: uniprot

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P31323 166
organism: Homo sapiens

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: uniprot P31321 165
xref: PTHR11635:SF126
organism: Homo sapiens

Adenylate cyclase type 8
type: ProteinReference
xref: PTHR45627:SF1
xref: uniprot P40146 244
organism: Rattus norvegicus

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 84

GABA-B receptor
type: ProteinReference
xref: P05756
standard name: Gamma-aminobutyric acid B receptor
comment: ENTITY_REFERENCE_ID_DESC=GABA-B_receptor_II_signaling.PROTEIN.RECEPTOR.GABA_minus_B_br_receptor
comment: ENTITY_REFERENCE_NOTES= Long Name: Gamma-aminobutyric acid B receptor Synonym: GABBR2,G protein-coupled receptor 51 Accession: P05756
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Gamma-aminobutyric acid type B receptor subunit 2
member entity reference: Uncharacterized protein
member entity reference: Gamma-aminobutyric acid type B receptor subunit 1
member entity reference: GABBR2 isoform 1

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P12369 156
xref: PTHR11635:SF156
organism: Rattus norvegicus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P12367 154
organism: Mus musculus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P12368 155
organism: Rattus norvegicus

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__K_channel-RIGHT__K_channel-_re21
controller: Gbetagamma complex

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot P51828 245
organism: Homo sapiens

Adenylate cyclase type 8
type: ProteinReference
xref: PTHR45627:SF1
xref: uniprot P40145 243
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MF15 120
xref: PTHR10519:SF42
organism: Bos taurus

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa13 301
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot F7GI54 49
organism: Monodelphis domestica

uniprot P27791 162
type: UnificationXref
id: P27791
db: uniprot

uniprot P26770 241
type: UnificationXref
id: P26770
db: uniprot

Adenylate cyclase type 7
type: ProteinReference
xref: uniprot P51829 246
xref: PTHR45627:SF9
organism: Mus musculus

uniprot P12849 157
type: UnificationXref
id: P12849
db: uniprot

uniprot E1BHU9 219
type: UnificationXref
id: E1BHU9
db: uniprot

ncbitaxon 9031 84
type: UnificationXref
id: 9031
db: ncbitaxon

Ggamma
type: ProteinReference
xref: P05754
comment: ENTITY_REFERENCE_ID_DESC=GABA-B_receptor_II_signaling.PROTEIN.GENERIC.G_gamma_
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Ggamma Synonym: Synonym not specified Accession: P05754
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
member entity reference: G protein subunit gamma 5

IDA
type: EvidenceCodeVocabulary

STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 319
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 318
left: AC
interaction type: STATE_TRANSITION
right: AC

uniprot H2QIU3 113
type: UnificationXref
id: H2QIU3
db: uniprot

AC
type: ProteinReference
xref: P05760
standard name: adenylate cyclase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Adenylate cyclase Synonym: adenylyl cyclase,adenyl cyclase Accession: P05760
comment: ENTITY_REFERENCE_ID_DESC=GABA-B_receptor_II_signaling.PROTEIN.GENERIC.AC
member entity reference: Adenylate cyclase type 6
member entity reference: Adenylate cyclase type 1
member entity reference: Adenylate cyclase
member entity reference: Adenylate cyclase type 5
member entity reference: Adenylate cyclase type 2
member entity reference: Adenylate cyclase type 4
member entity reference: Adenylate cyclase type 9
member entity reference: Adenylate cyclase type 8
member entity reference: Adenylate cyclase type 7
member entity reference: Uncharacterized protein
member entity reference: Adenylate cyclase 9
member entity reference: ADCY9 isoform 1
member entity reference: Adenylyl CYclase family member (Acy-1)-like

Ca channel
type: ProteinReference
xref: P05753
standard name: Voltage-dependent Ca channel
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES=Long Name: Voltage-dependent Ca channel Synonym: Synonym not specified Accession: P05753
comment: ENTITY_REFERENCE_ID_DESC=GABA-B_receptor_II_signaling.PROTEIN.ION_CHANNEL.Ca channel
member entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha
member entity reference: Voltage-dependent T-type calcium channel subunit alpha-1G
member entity reference: Voltage-dependent T-type calcium channel subunit alpha
member entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
member entity reference: Voltage-dependent N-type calcium channel subunit alpha-1B
member entity reference: Voltage-dependent N-type calcium channel subunit alpha

uniprot P54313 201
type: UnificationXref
id: P54313
db: uniprot

uniprot Q9UK08 82
type: UnificationXref
id: Q9UK08
db: uniprot

Ggamma s14 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

Adenylate cyclase type 7
type: ProteinReference
xref: uniprot Q29450 255
xref: PTHR45627:SF9
organism: Bos taurus

uniprot O43497 14
type: UnificationXref
id: O43497
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 187
xref: PTHR19850:SF29
organism: Monodelphis domestica

uniprot H2QFK0 142
type: UnificationXref
id: H2QFK0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 188
xref: PTHR19850:SF27
organism: Monodelphis domestica

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: uniprot P22612 160
xref: PTHR24353:SF137
organism: Homo sapiens

uniprot H2R3M7 145
type: UnificationXref
id: H2R3M7
db: uniprot

Adenylate cyclase type 5
type: ProteinReference
xref: PTHR45627:SF7
xref: uniprot O95622 239
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot F6XHP0 40
organism: Macaca mulatta

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa8 267
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot F6TFY2 37
type: UnificationXref
id: F6TFY2
db: uniprot

GABA-B receptor/ GABA complex
type: Complex
component stoichiometry: GABA B receptor s29 sa15 STOICHIOMETRY ID COMPLEX
component stoichiometry: GABA s38 sa16 STOICHIOMETRY ID COMPLEX
component: GABA
component: GABA-B receptor
feature: COMPLEX BINDING FEATURE s28 csa4 310
feature: COMPLEX BINDING FEATURE s28 csa4 308
cellular location: axon terminus

Gbeta s25 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

uniprot F7DL70 229
type: UnificationXref
id: F7DL70
db: uniprot

Gi/oalpha
type: Protein
entity reference: Gi/oalpha
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot F6Q9S4 135
xref: PTHR11635:SF156
organism: Bos taurus

uniprot O60503 237
type: UnificationXref
id: O60503
db: uniprot

SNARE Complex s54 sa42 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CXD0 191
xref: PTHR19850:SF31
organism: Monodelphis domestica

uniprot O54898 16
type: UnificationXref
id: O54898
db: uniprot

Protein kinase cAMP-activated catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H2QFK0 142
organism: Pan troglodytes

uniprot Q80SZ7 80
type: UnificationXref
id: Q80SZ7
db: uniprot

uniprot E2R738 119
type: UnificationXref
id: E2R738
db: uniprot

STATE_TRANSITION_LEFT__K_channel-RIGHT__K_channel-_re21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 333
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 334
left: K channel
interaction type: STATE_TRANSITION
right: K channel

Adenylate cyclase type 6
type: ProteinReference
xref: uniprot Q01341 250
xref: PTHR45627:SF11
organism: Mus musculus

uniprot H2QXB9 143
type: UnificationXref
id: H2QXB9
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 34
xref: PTHR13809:SF19
organism: Bos taurus

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot H2RER5 146
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re8 317
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re8 316
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

Gi/oalpha
type: Protein
entity reference: Gi/oalpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa11 289
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7BB02 44
xref: PTHR13809:SF8
organism: Macaca mulatta

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 211
xref: PTHR19850:SF29
organism: Danio rerio

uniprot P00517 150
type: UnificationXref
id: P00517
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF11
xref: uniprot F7H582 230
organism: Macaca mulatta

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF11
xref: uniprot E1B9K3 218
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re5 322
type: Stoichiometry
physical entity: Ca channel
stoichiometric coefficient: 1.0

uniprot E1BW98 184
type: UnificationXref
id: E1BW98
db: uniprot

PARTICIPANT STOICHIOMETRY re5 323
type: Stoichiometry
physical entity: Ca channel
stoichiometric coefficient: 1.0

Adenylate cyclase
type: ProteinReference
xref: uniprot F7HUD3 231
xref: PTHR45627:SF12
organism: Macaca mulatta

GABA-B receptor/ GABA complex
type: Complex
component stoichiometry: GABA B receptor s79 sa58 STOICHIOMETRY ID COMPLEX
component stoichiometry: GABA s78 sa57 STOICHIOMETRY ID COMPLEX
component: GABA-B receptor
component: GABA
feature: COMPLEX BINDING FEATURE s77 csa10 312
feature: COMPLEX BINDING FEATURE s77 csa10 314
cellular location: axon terminus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot Q3KRE3 76
organism: Rattus norvegicus

uniprot F7CTP1 190
type: UnificationXref
id: F7CTP1
db: uniprot

uniprot F7CEX4 228
type: UnificationXref
id: F7CEX4
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot O60262 59
xref: PTHR13809:SF8
organism: Homo sapiens

PTHR24353:SF82
type: RelationshipXref
id: PTHR24353:SF82
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot Q3ZCA7 105
organism: Bos taurus

GABA-B receptor
type: Protein
entity reference: GABA-B receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s66 sa48 269
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Gi/oalpha
type: Protein
entity reference: Gi/oalpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa6 263
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Adenylate cyclase 9
type: ProteinReference
xref: PTHR45627:SF8
xref: uniprot E2R4W4 222
organism: Canis lupus familiaris

GABA B receptor s12 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GABA-B receptor
stoichiometric coefficient: 1.0

Gamma-aminobutyric acid type B receptor subunit 2
type: ProteinReference
xref: uniprot O88871 124
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF28
xref: uniprot D3ZLD6 28
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5PCI4 129
xref: PTHR11635:SF126
organism: Gallus gallus

uniprot R4GKD1 83
type: UnificationXref
id: R4GKD1
db: uniprot

uniprot Q61011 209
type: UnificationXref
id: Q61011
db: uniprot

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s81 sa59 305
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot H2QNS5 195
type: UnificationXref
id: H2QNS5
db: uniprot

PTHR24353:SF37
type: RelationshipXref
id: PTHR24353:SF37
db: PANTHER Family
relationship type: By Homology

uniprot Q6PH57 210
type: UnificationXref
id: Q6PH57
db: uniprot

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa7 265
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Adenylyl CYclase family member (Acy-1)-like
type: ProteinReference
xref: PTHR45627:SF8
xref: uniprot E1BM79 220
organism: Bos taurus

MODULATION
type: Control
xref: MODULATION
controlled: Target ion channel
controller: PKA

uniprot F7G3J2 194
type: UnificationXref
id: F7G3J2
db: uniprot

DISSOCIATION
type: InteractionVocabulary

PTHR13809:SF51
type: RelationshipXref
id: PTHR13809:SF51
db: PANTHER Family
relationship type: By Homology

uniprot F6XHP0 40
type: UnificationXref
id: F6XHP0
db: uniprot

uniprot F1LQT1 224
type: UnificationXref
id: F1LQT1
db: uniprot

uniprot F1MF15 120
type: UnificationXref
id: F1MF15
db: uniprot

GO GO:0008021 3
type: UnificationXref
id: GO:0008021
db: GO

uniprot P30671 60
type: UnificationXref
id: P30671
db: uniprot

PARTICIPANT STOICHIOMETRY re4 324
type: Stoichiometry
physical entity: GABA-B receptor/ GABA/ G protein complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 325
type: Stoichiometry
physical entity: GABA-B receptor/ GABA complex
stoichiometric coefficient: 1.0

GNB4 protein
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot A5PKD6 183
organism: Bos taurus

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 13

PARTICIPANT STOICHIOMETRY re4 326
type: Stoichiometry
physical entity: Gi/oalpha
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 327
type: Stoichiometry
physical entity: Gbetagamma complex
stoichiometric coefficient: 1.0

Adenylate cyclase type 4
type: ProteinReference
xref: uniprot P26770 241
xref: PTHR45627:SF10
organism: Rattus norvegicus

uniprot P50154 64
type: UnificationXref
id: P50154
db: uniprot

PTHR11635:SF156
type: RelationshipXref
id: PTHR11635:SF156
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF153
type: RelationshipXref
id: PTHR11635:SF153
db: PANTHER Family
relationship type: By Homology

Ca2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

PTHR11635:SF152
type: RelationshipXref
id: PTHR11635:SF152
db: PANTHER Family
relationship type: By Homology

uniprot H2R3Y0 121
type: UnificationXref
id: H2R3Y0
db: uniprot

Gbeta s22 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot Q7ZW82 107
organism: Danio rerio

Ggamma s73 sa54 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

uniprot O43306 236
type: UnificationXref
id: O43306
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot F7HAK5 141
organism: Macaca mulatta

Voltage-dependent N-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot G3X7Z2 11
xref: PTHR10037:SF289
organism: Bos taurus

ncbitaxon 6239 164
type: UnificationXref
id: 6239
db: ncbitaxon

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P22694 161
xref: PTHR24353:SF116
organism: Homo sapiens

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s73 sa54 295
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

PTHR45628:SF6
type: RelationshipXref
id: PTHR45628:SF6
db: PANTHER Family
relationship type: By Homology

Ggamma s82 sa60 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

PTHR45628:SF3
type: RelationshipXref
id: PTHR45628:SF3
db: PANTHER Family
relationship type: By Homology

PRKAR2A isoform 1
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot K7AEL3 147
organism: Pan troglodytes

uniprot O88871 124
type: UnificationXref
id: O88871
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot R4GKD1 83
organism: Gallus gallus

GABA-B receptor/ G protein complex
type: Complex
component stoichiometry: Ggamma s69 sa51 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s68 sa50 STOICHIOMETRY ID COMPLEX
component stoichiometry: GABA B receptor s66 sa48 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gi oalpha s67 sa49 STOICHIOMETRY ID COMPLEX
component: Ggamma
component: Gbeta
component: Gi/oalpha
component: GABA-B receptor
feature: COMPLEX BINDING FEATURE s65 csa8 268
feature: COMPLEX BINDING FEATURE s65 csa8 274
feature: COMPLEX BINDING FEATURE s65 csa8 270
feature: COMPLEX BINDING FEATURE s65 csa8 272
cellular location: axon terminus

uniprot A0A2I3S4R3 85
type: UnificationXref
id: A0A2I3S4R3
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 46
xref: PTHR13809:SF19
organism: Macaca mulatta

uniprot P61954 67
type: UnificationXref
id: P61954
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot G3V8K2 50
organism: Rattus norvegicus

By Homology
type: RelationshipTypeVocabulary

uniprot H2Q1D9 53
type: UnificationXref
id: H2Q1D9
db: uniprot

ncbitaxon 44689 169
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot E1BNE9 109
type: UnificationXref
id: E1BNE9
db: uniprot

uniprot P63216 72
type: UnificationXref
id: P63216
db: uniprot

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: PTHR11767:SF16
xref: uniprot P48549 114
organism: Homo sapiens

PTHR45627:SF9
type: RelationshipXref
id: PTHR45627:SF9
db: PANTHER Family
relationship type: By Homology

uniprot P63078 69
type: UnificationXref
id: P63078
db: uniprot

uniprot F7GQC5 95
type: UnificationXref
id: F7GQC5
db: uniprot

Voltage-dependent T-type calcium channel subunit alpha-1G
type: ProteinReference
xref: uniprot O54898 16
xref: PTHR10037:SF137
organism: Rattus norvegicus

PTHR45627:SF7
type: RelationshipXref
id: PTHR45627:SF7
db: PANTHER Family
relationship type: By Homology

PTHR45627:SF8
type: RelationshipXref
id: PTHR45627:SF8
db: PANTHER Family
relationship type: By Homology

uniprot P68182 171
type: UnificationXref
id: P68182
db: uniprot

PTHR45627:SF6
type: RelationshipXref
id: PTHR45627:SF6
db: PANTHER Family
relationship type: By Homology

uniprot Q80T41 125
type: UnificationXref
id: Q80T41
db: uniprot

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 169

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F2Z3T8 36
xref: PTHR13809:SF5
organism: Rattus norvegicus

PTHR45627:SF1
type: RelationshipXref
id: PTHR45627:SF1
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot Q5E9F0 77
type: UnificationXref
id: Q5E9F0
db: uniprot

PTHR11635:SF129
type: RelationshipXref
id: PTHR11635:SF129
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF126
type: RelationshipXref
id: PTHR11635:SF126
db: PANTHER Family
relationship type: By Homology

Gamma-aminobutyric acid type B receptor subunit 2
type: ProteinReference
xref: PTHR10519:SF67
xref: uniprot O75899 122
organism: Homo sapiens

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 15

uniprot P05132 152
type: UnificationXref
id: P05132
db: uniprot

uniprot F6WTY3 111
type: UnificationXref
id: F6WTY3
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot K7E376 56
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: PTHR13809:SF1
xref: uniprot P61954 67
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot P61952 65
xref: PTHR13809:SF1
organism: Homo sapiens

uniprot P40145 243
type: UnificationXref
id: P40145
db: uniprot

AC
type: Protein
entity reference: AC
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: PTHR13809:SF1
xref: uniprot P61953 66
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 80
xref: PTHR13809:SF5
organism: Mus musculus

K+
type: SmallMolecule
comment: SPECIES_TYPE=ION

uniprot P22612 160
type: UnificationXref
id: P22612
db: uniprot

uniprot E2R4W4 222
type: UnificationXref
id: E2R4W4
db: uniprot

uniprot E2RRA1 131
type: UnificationXref
id: E2RRA1
db: uniprot

PTHR10037:SF137
type: RelationshipXref
id: PTHR10037:SF137
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9598 52
type: UnificationXref
id: 9598
db: ncbitaxon

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot F6ZIZ9 189
organism: Macaca mulatta

uniprot F7BCI5 227
type: UnificationXref
id: F7BCI5
db: uniprot

uniprot F7G4Q0 140
type: UnificationXref
id: F7G4Q0
db: uniprot

Gi/oalpha
type: Protein
entity reference: Gi/oalpha
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

AC
type: Protein
entity reference: AC
feature: ACTIVE 24
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

GABA-B receptor
type: Protein
entity reference: GABA-B receptor
feature: ACTIVE 24
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa4 281
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot H2QUJ4 233
type: UnificationXref
id: H2QUJ4
db: uniprot

uniprot O00555 12
type: UnificationXref
id: O00555
db: uniprot

G protein subunit beta 3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot H2R3A6 196
organism: Pan troglodytes

uniprot F7ES96 46
type: UnificationXref
id: F7ES96
db: uniprot

TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re22
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 332
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 331
left: K+
interaction type: TRANSPORT
right: K+

Adenylate cyclase
type: ProteinReference
xref: uniprot F6ZAV4 226
xref: PTHR45627:SF6
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F7A472 94
organism: Xenopus tropicalis

uniprot K7CYN2 235
type: UnificationXref
id: K7CYN2
db: uniprot

uniprot P62880 207
type: UnificationXref
id: P62880
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

Gamma-aminobutyric acid type B receptor subunit 2
type: ProteinReference
xref: PTHR10519:SF67
xref: uniprot E2R738 119
organism: Canis lupus familiaris

TRANSPORT
type: InteractionVocabulary

uniprot P13861 158
type: UnificationXref
id: P13861
db: uniprot

uniprot Q9CXP8 81
type: UnificationXref
id: Q9CXP8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G4Q0 140
xref: PTHR24353:SF82
organism: Monodelphis domestica

PRKACG isoform 1
type: ProteinReference
xref: uniprot H2QXB9 143
xref: PTHR24353:SF137
organism: Pan troglodytes

uniprot E2RCX6 223
type: UnificationXref
id: E2RCX6
db: uniprot

PTHR45628:SF15
type: RelationshipXref
id: PTHR45628:SF15
db: PANTHER Family
relationship type: By Homology

PKA
type: ProteinReference
xref: P05752
standard name: Protein kinase A
comment: ENTITY_REFERENCE_ID_DESC=GABA-B_receptor_II_signaling.PROTEIN.GENERIC.PKA
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: cAMP-dependent protein kinase Synonym: Synonym not specified Accession: P05752
member entity reference: Protein kinase, X-linked
member entity reference: Protein kinase cAMP-activated catalytic subunit beta
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit beta
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha
member entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit
member entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit beta
member entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit
member entity reference: PRKACB isoform 3
member entity reference: PRKAR1A isoform 12
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
member entity reference: PRKAR2A isoform 1
member entity reference: PRKACG isoform 1
member entity reference: Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
member entity reference: Protein kinase, cAMP-dependent, regulatory, type I, beta
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta
member entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit
member entity reference: Uncharacterized protein
member entity reference: cAMP-dependent protein kinase catalytic subunit beta isoform 1
member entity reference: cAMP-dependent protein kinase catalytic subunit PRKX
member entity reference: Protein kinase cAMP-activated catalytic subunit alpha
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit alpha
member entity reference: Prkar1a protein
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
member entity reference: cAMP-dependent protein kinase catalytic subunit gamma
member entity reference: cAMP-dependent protein kinase catalytic subunit
member entity reference: Protein kinase cAMP-dependent type I regulatory subunit alpha
member entity reference: cAMP-dependent protein kinase regulatory subunit

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot F7DL70 229
organism: Macaca mulatta

uniprot F6PGC8 186
type: UnificationXref
id: F6PGC8
db: uniprot

uniprot Q29450 255
type: UnificationXref
id: Q29450
db: uniprot

uniprot P50150 62
type: UnificationXref
id: P50150
db: uniprot

uniprot H2PZK9 96
type: UnificationXref
id: H2PZK9
db: uniprot

PTHR11767:SF16
type: RelationshipXref
id: PTHR11767:SF16
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RFY5 214
organism: Macaca mulatta

uniprot D3ZLD6 28
type: UnificationXref
id: D3ZLD6
db: uniprot

uniprot P62874 205
type: UnificationXref
id: P62874
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot F7ERP8 45
organism: Ornithorhynchus anatinus

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s68 sa50 273
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot H2Q832 232
type: UnificationXref
id: H2Q832
db: uniprot

uniprot A0A1D5RFW3 118
type: UnificationXref
id: A0A1D5RFW3
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta isoform 1
type: ProteinReference
xref: uniprot F7EBQ5 139
xref: PTHR24353:SF116
organism: Macaca mulatta

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: PTHR11767:SF16
xref: uniprot Q90854 117
organism: Gallus gallus