PARTICIPANT STOICHIOMETRY re23 236
type: Stoichiometry
physical entity: phosphoSAX/ GBB/PUT MAD
stoichiometric coefficient: 1.0

MAD s151 sa123 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re23 235
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re23 234
type: Stoichiometry
physical entity: phosphoSAX/ GBB/PUT
stoichiometric coefficient: 1.0

PDP
type: ProteinReference
xref: P06297
standard name: pyruvate dehydrogenase phosphatase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=GBB_signaling_pathway.PROTEIN.GENERIC.PDP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: GM14286p

WIT
type: Complex
component stoichiometry: WIT s68 sa48 STOICHIOMETRY ID COMPLEX
component: WIT
feature: COMPLEX PARTICIPANT BINDING FEATURE s68 sa48 105
cellular location: cytosol

WIT
type: Complex
component stoichiometry: WIT s80 sa26 STOICHIOMETRY ID COMPLEX
component: WIT
feature: COMPLEX PARTICIPANT BINDING FEATURE s80 sa26 149
cellular location: cytosol

WIT
type: Complex
component stoichiometry: WIT s84 sa58 STOICHIOMETRY ID COMPLEX
component: WIT
feature: COMPLEX PARTICIPANT BINDING FEATURE s84 sa58 135
cellular location: cytosol

WIT
type: Protein
entity reference: WIT

WIT
type: Complex
component stoichiometry: WIT s95 sa68 STOICHIOMETRY ID COMPLEX
component: WIT
feature: COMPLEX PARTICIPANT BINDING FEATURE s95 sa68 143
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re34 321
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

WIT
type: Complex
component stoichiometry: WIT s58 sa37 STOICHIOMETRY ID COMPLEX
component: WIT
cellular location: endoplasmic reticulum

PARTICIPANT STOICHIOMETRY re34 320
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 3.0

WIT
type: Complex
component stoichiometry: WIT s7 sa9 STOICHIOMETRY ID COMPLEX
component: WIT
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa9 195
cellular location: cytosol

WIT
type: Complex
component stoichiometry: WIT s46 sa17 STOICHIOMETRY ID COMPLEX
component: WIT
feature: COMPLEX PARTICIPANT BINDING FEATURE s46 sa17 155
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re34 322
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 270
type: Stoichiometry
physical entity: GBB/ TKV
stoichiometric coefficient: 1.0

WIT
type: Complex
component stoichiometry: WIT s47 sa20 STOICHIOMETRY ID COMPLEX
component: WIT
feature: COMPLEX PARTICIPANT BINDING FEATURE s47 sa20 119
cellular location: cytosol

MAD s98 sa67 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

HETERODIMER_ASSOCIATION_LEFT__phosphoTKV__GBB_WIT-_MAD-RIGHT__phosphoTKV__GBB_WIT_MAD-_re22
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 241
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 243
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 242
left: MAD
left: phosphoTKV/ GBB/WIT
interaction type: HETERODIMER_ASSOCIATION
right: phosphoTKV/ GBB/WIT MAD

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 2

TKV
type: Complex
component stoichiometry: TKV s121 sa69 STOICHIOMETRY ID COMPLEX
component: TKV
feature: COMPLEX PARTICIPANT BINDING FEATURE s121 sa69 145
cellular location: cytosol

GBB s75 sa53 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

WIT
type: Complex
component stoichiometry: WIT s5 sa2 STOICHIOMETRY ID COMPLEX
component: WIT
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re11 305
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

SAX
type: Protein
entity reference: SAX
feature: SAX s59 sa40 rs1

PARTICIPANT STOICHIOMETRY re11 304
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re11 303
type: Stoichiometry
physical entity: proGBB
stoichiometric coefficient: 1.0

GBB
type: Protein
entity reference: GBB

SHN
type: Protein
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

GBB s85 sa59 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

SAX/GBB/ PUT
type: Complex
component stoichiometry: HOMODIMER ID 13STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 31STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 74STOICHIOMETRY ID COMPLEX
component: GBB
component: SAX
component: PUT
feature: COMPLEX BINDING FEATURE s15 csa4 176
feature: COMPLEX BINDING FEATURE s15 csa4 174
feature: COMPLEX BINDING FEATURE s15 csa4 172
cellular location: cytosol

MAD s98 sa67 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

WIT
type: Protein
entity reference: WIT

proGBB
type: Complex
component stoichiometry: HOMODIMER ID 80STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 69STOICHIOMETRY ID COMPLEX
component: ?
component: GBB
feature: COMPLEX BINDING FEATURE s53 csa10 204
feature: COMPLEX BINDING FEATURE s53 csa10 206

TKV
type: Complex
component stoichiometry: TKV s28 sa21 STOICHIOMETRY ID COMPLEX
component: TKV
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa21 121
cellular location: cytosol

Target genes
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

TKV
type: Complex
component stoichiometry: TKV s69 sa49 STOICHIOMETRY ID COMPLEX
component: TKV
feature: COMPLEX PARTICIPANT BINDING FEATURE s69 sa49 107
cellular location: cytosol

TKV
type: Complex
component stoichiometry: TKV s3 sa7 STOICHIOMETRY ID COMPLEX
component: TKV
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa7 111
cellular location: cytosol

TKV
type: Complex
component stoichiometry: TKV s8 sa10 STOICHIOMETRY ID COMPLEX
component: TKV
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa10 197
cellular location: cytosol

TKV
type: Complex
component stoichiometry: TKV s1 sa1 STOICHIOMETRY ID COMPLEX
component: TKV
cellular location: cytosol

TKV s3 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

TKV
type: Complex
component stoichiometry: TKV s62 sa43 STOICHIOMETRY ID COMPLEX
component: TKV
cellular location: endoplasmic reticulum

MAD
type: ProteinReference
xref: P06305
standard name: mothers against dpp
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=GBB_signaling_pathway.PROTEIN.GENERIC.MAD
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein mothers against dpp

GBB
type: Protein
entity reference: GBB

HOMODIMER ID 14STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re1 268
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

SAX
type: Complex
component stoichiometry: SAX s138 sa82 STOICHIOMETRY ID COMPLEX
component: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s138 sa82 215
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re1 269
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

SAX
type: Complex
component stoichiometry: SAX s104 sa74 STOICHIOMETRY ID COMPLEX
component: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s104 sa74 181
cellular location: cytosol

SAX
type: Complex
component stoichiometry: SAX s86 sa60 STOICHIOMETRY ID COMPLEX
component: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s86 sa60 139
cellular location: cytosol

MAD s67 sa47 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

MAD
type: Protein
entity reference: MAD
feature: MAD s112 sa79 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s112 sa79 209
feature: MAD s112 sa79 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SAX s24 sa19 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

GBB full length
type: Protein

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 7

HOMODIMER ID 56STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

GBB
type: Complex
component stoichiometry: GBB s10 sa3 STOICHIOMETRY ID COMPLEX
component: GBB

HOMODIMER ID 62STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

WIT
type: Protein
entity reference: WIT

GBB
type: Complex
component stoichiometry: GBB s9 sa11 STOICHIOMETRY ID COMPLEX
component: GBB
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa11 199
cellular location: cytosol

GBB
type: Complex
component stoichiometry: GBB s14 sa13 STOICHIOMETRY ID COMPLEX
component: GBB
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa13 117
cellular location: cytosol

GBB
type: Complex
component stoichiometry: GBB s18 sa16 STOICHIOMETRY ID COMPLEX
component: GBB
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa16 177
cellular location: cytosol

PTHR13703:SF61
type: RelationshipXref
id: PTHR13703:SF61
db: PANTHER Family
relationship type: By Homology

GBB
type: Complex
component stoichiometry: GBB s23 sa18 STOICHIOMETRY ID COMPLEX
component: GBB
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa18 157
cellular location: cytosol

GBB
type: Complex
component stoichiometry: GBB s27 sa22 STOICHIOMETRY ID COMPLEX
component: GBB
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa22 123
cellular location: cytosol

MAD s87 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

GBB
type: Complex
component stoichiometry: GBB s42 sa25 STOICHIOMETRY ID COMPLEX
component: GBB
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa25 165
cellular location: cytosol

GBB
type: Complex
component stoichiometry: GBB s44 sa8 STOICHIOMETRY ID COMPLEX
component: GBB
feature: COMPLEX PARTICIPANT BINDING FEATURE s44 sa8 113
cellular location: cytosol

GBB
type: Complex
component stoichiometry: GBB s51 sa32 STOICHIOMETRY ID COMPLEX
component: GBB
feature: COMPLEX PARTICIPANT BINDING FEATURE s51 sa32 201
cellular location: Golgi apparatus

?
type: Complex
component stoichiometry: ? s54 sa34 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s54 sa34 205

WIT
type: Protein
entity reference: WIT

MAD
type: Protein
entity reference: MAD
feature: MAD s106 sa76 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s106 sa76 185
feature: MAD s106 sa76 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MED/ phosphoMAD
type: Complex
component stoichiometry: TKV s96 sa93 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 60STOICHIOMETRY ID COMPLEX
component: MAD
component: MED
feature: COMPLEX BINDING FEATURE s118 csa17 90
feature: COMPLEX BINDING FEATURE s118 csa17 88
cellular location: cytosol

MED s142 sa116 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

TKV s28 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

GO GO:0005794 4
type: UnificationXref
id: GO:0005794
db: GO

MAD
type: Complex
component stoichiometry: MAD s119 sa92 STOICHIOMETRY ID COMPLEX
component: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s119 sa92 89
cellular location: cytosol

PTHR47992:SF25
type: RelationshipXref
id: PTHR47992:SF25
db: PANTHER Family
relationship type: By Homology

GBB
type: Protein
entity reference: GBB

SAX
type: Protein
entity reference: SAX
feature: SAX s17 sa15 rs1

SAX s32 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

MAD
type: Complex
component stoichiometry: MAD s141 sa115 STOICHIOMETRY ID COMPLEX
component: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s141 sa115 93
cellular location: nucleus

SAX s17 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

MAD
type: Complex
component stoichiometry: MAD s113 sa109 STOICHIOMETRY ID COMPLEX
component: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s113 sa109 97
cellular location: nucleus

MAD
type: Complex
component stoichiometry: MAD s126 sa112 STOICHIOMETRY ID COMPLEX
component: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s126 sa112 167
cellular location: nucleus

STATE_TRANSITION_LEFT__MED-_MAD-RIGHT__MED__phosphoMAD-_MAD-_re34
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 322
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 321
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 319
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 320
left: MAD
left: MED
interaction type: STATE_TRANSITION
right: MED/ phosphoMAD
right: MAD

?
type: Complex
component stoichiometry: ? s56 sa31 STOICHIOMETRY ID COMPLEX
component: ?

?
type: Complex
component stoichiometry: ? s52 sa33 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s52 sa33 203
cellular location: Golgi apparatus

PARTICIPANT STOICHIOMETRY re34 319
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

MAD
type: Complex
component stoichiometry: MAD s117 sa90 STOICHIOMETRY ID COMPLEX
component: MAD
cellular location: cytosol

WIT
type: Complex
component stoichiometry: WIT s136 sa80 STOICHIOMETRY ID COMPLEX
component: WIT
feature: COMPLEX PARTICIPANT BINDING FEATURE s136 sa80 211
cellular location: cytosol

TKV
type: Protein
entity reference: TKV
feature: TKV s3 sa7 rs1

HOMODIMER ID 87STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

PUT
type: Complex
component stoichiometry: PUT s45 sa5 STOICHIOMETRY ID COMPLEX
component: PUT
cellular location: cytosol

PTHR13703:SF45
type: RelationshipXref
id: PTHR13703:SF45
db: PANTHER Family
relationship type: By Homology

PUT
type: Complex
component stoichiometry: PUT s30 sa14 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa14 173
cellular location: cytosol

GBB s27 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

phosphoMAD LACK
type: Complex
component stoichiometry: MAD s155 sa121 STOICHIOMETRY ID COMPLEX
component stoichiometry: LACK s154 sa122 STOICHIOMETRY ID COMPLEX
component: LACK
component: MAD
feature: COMPLEX BINDING FEATURE s153 csa21 130
feature: COMPLEX BINDING FEATURE s153 csa21 128
cellular location: cytosol

PUT
type: Complex
component stoichiometry: PUT s63 sa44 STOICHIOMETRY ID COMPLEX
component: PUT
cellular location: endoplasmic reticulum

PUT
type: Protein
entity reference: PUT
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re49 277
type: Stoichiometry
physical entity: phosphoMAD LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re49 276
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

MAD s119 sa92 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

GBB
type: Protein
entity reference: GBB

phosphoMAD LACK
type: Complex
component stoichiometry: MED s114 sa124 STOICHIOMETRY ID COMPLEX
component stoichiometry: MAD s151 sa123 STOICHIOMETRY ID COMPLEX
component: MAD
component: LACK
feature: COMPLEX BINDING FEATURE s149 csa22 126
feature: COMPLEX BINDING FEATURE s149 csa22 124
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re49 275
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

MAD s76 sa54 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

PARTICIPANT STOICHIOMETRY re32 327
type: Stoichiometry
physical entity: phosphoTKV/ GBB/WIT
stoichiometric coefficient: 1.0

MAD s117 sa90 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

PARTICIPANT STOICHIOMETRY re32 326
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re32 325
type: Stoichiometry
physical entity: phosphoTKV/ GBB/WIT phosphoMAD
stoichiometric coefficient: 1.0

HOMODIMER ID 82STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

MAD
type: Protein
entity reference: MAD
feature: MAD s141 sa115 rs1
feature: MAD s141 sa115 rs2

MAD s126 sa112 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SAX
type: Protein
entity reference: SAX
feature: SAX s13 sa12 rs1

uniprot Q961C5 65
type: UnificationXref
id: Q961C5
db: uniprot

GBB s18 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

GBB
type: Protein
entity reference: GBB

HETERODIMER_ASSOCIATION_LEFT__PUT-_GBB__SAX-RIGHT__SAX_GBB__PUT-_re5
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 258
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 257
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 256
left: GBB/ SAX
left: PUT
interaction type: HETERODIMER_ASSOCIATION
right: SAX/GBB/ PUT

SAX
type: Protein
entity reference: SAX
feature: SAX s86 sa60 rs1

HOMODIMER ID 84STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

PUT
type: Protein
entity reference: PUT

HETERODIMER_ASSOCIATION_LEFT__phosphoSAX__GBB_WIT-_MAD-RIGHT__phosphoSAX__GBB_WIT_MAD-_re24
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 229
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 230
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 228
left: phosphoSAX/ GBB/WIT
left: MAD
interaction type: HETERODIMER_ASSOCIATION
right: phosphoSAX/ GBB/WIT MAD

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__GBB_full_length-RIGHT__?-_GBB-_re9
controller: FUR1

TKV s121 sa69 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re42 306
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re42 307
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

WIT
type: Protein
entity reference: WIT

SAX s11 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re21 249
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

HOMODIMER ID 77STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

PPM1A
type: ProteinReference
xref: P06296
standard name: protein phosphatase 2C alpha, beta
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=GBB_signaling_pathway.PROTEIN.GENERIC.PPM1A
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Alphabet, isoform E

PARTICIPANT STOICHIOMETRY re21 248
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

MAD s112 sa79 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SAX
type: Complex
component stoichiometry: SAX s17 sa15 STOICHIOMETRY ID COMPLEX
component: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa15 175
cellular location: cytosol

SAX
type: Complex
component stoichiometry: SAX s13 sa12 STOICHIOMETRY ID COMPLEX
component: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa12 115
cellular location: cytosol

SAX
type: Complex
component stoichiometry: SAX s32 sa24 STOICHIOMETRY ID COMPLEX
component: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa24 163
cellular location: cytosol

HETERODIMER_ASSOCIATION_LEFT__NEJ-_MED__phosphoMAD-RIGHT__NEJ_MED__phosphoMAD-_re37
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 314
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 315
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 313
left: MED/ phosphoMAD
left: NEJ
interaction type: HETERODIMER_ASSOCIATION
right: NEJ/MED/ phosphoMAD

SAX
type: Complex
component stoichiometry: SAX s24 sa19 STOICHIOMETRY ID COMPLEX
component: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa19 159
cellular location: cytosol

SAX
type: Complex
component stoichiometry: SAX s82 sa28 STOICHIOMETRY ID COMPLEX
component: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s82 sa28 153
cellular location: cytosol

HOMODIMER ID 72STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

SAX
type: Complex
component stoichiometry: SAX s74 sa52 STOICHIOMETRY ID COMPLEX
component: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s74 sa52 189
cellular location: cytosol

SAX s13 sa12 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re37 315
type: Stoichiometry
physical entity: NEJ/MED/ phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re37 314
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

Golgi apparatus
type: CellularLocationVocabulary
xref: GO GO:0005794 4

phosphoSAX/ GBB/WIT
type: Complex
component stoichiometry: HOMODIMER ID 55STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 35STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 83STOICHIOMETRY ID COMPLEX
component: WIT
component: SAX
component: GBB
feature: COMPLEX BINDING FEATURE s38 csa8 148
feature: COMPLEX BINDING FEATURE s38 csa8 150
feature: COMPLEX BINDING FEATURE s38 csa8 152
cellular location: cytosol

MAD s106 sa76 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re12 299
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re13 295
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re13 296
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

MAD s106 sa76 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

DISSOCIATION_LEFT__phosphoMAD_LACK-RIGHT__MAD-_LACK-_re47
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re47 286
participant stoichiometry: PARTICIPANT STOICHIOMETRY re47 284
participant stoichiometry: PARTICIPANT STOICHIOMETRY re47 285
left: phosphoMAD LACK
interaction type: DISSOCIATION
right: LACK
right: MAD

PARTICIPANT STOICHIOMETRY re37 313
type: Stoichiometry
physical entity: NEJ
stoichiometric coefficient: 1.0

MAD s112 sa79 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

SAX
type: Protein
entity reference: SAX
feature: SAX s11 sa4 rs1

GBB s55 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

SAX
type: Complex
component stoichiometry: SAX s11 sa4 STOICHIOMETRY ID COMPLEX
component: SAX
cellular location: cytosol

SAX
type: Complex
component stoichiometry: SAX s59 sa40 STOICHIOMETRY ID COMPLEX
component: SAX
cellular location: endoplasmic reticulum

WIT s95 sa68 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

uniprot P42003 22
type: UnificationXref
id: P42003
db: uniprot

MAD
type: Protein
entity reference: MAD
feature: MAD s116 sa87 rs1
feature: MAD s116 sa87 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MAD s119 sa92 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MAD
type: Protein
entity reference: MAD
feature: MAD s155 sa121 rs2
feature: MAD s155 sa121 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s155 sa121 129
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

WIT s80 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

GBB
type: Protein
entity reference: GBB

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_phosphoSAX__GBB_WIT_MAD-RIGHT__ADP-_phosphoSAX__GBB_WIT_phosphoMAD-_re27
controller: SAX

HOMODIMER ID 13STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot M9PE88 48
xref: PTHR23255:SF63
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re5 257
type: Stoichiometry
physical entity: GBB/ SAX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 256
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re5 258
type: Stoichiometry
physical entity: SAX/GBB/ PUT
stoichiometric coefficient: 1.0

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 3

PTHR13832:SF571
type: RelationshipXref
id: PTHR13832:SF571
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re48 280
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re48 281
type: Stoichiometry
physical entity: sa105_degraded
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__GBB__TKV-_WIT-RIGHT__TKV_GBB__WIT-_re3
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 264
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 262
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 263
left: WIT
left: GBB/ TKV
interaction type: HETERODIMER_ASSOCIATION
right: TKV/GBB/ WIT

LACK s154 sa122 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

WIT s47 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re26 222
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 2.0

TRUNCATION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re26 223
type: Stoichiometry
physical entity: phosphoSAX/ GBB/PUT phosphoMAD
stoichiometric coefficient: 1.0

MAD s126 sa112 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

PARTICIPANT STOICHIOMETRY re26 220
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re26 221
type: Stoichiometry
physical entity: phosphoSAX/ GBB/PUT MAD
stoichiometric coefficient: 1.0

PUT
type: Complex
component stoichiometry: PUT s103 sa73 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s103 sa73 179
cellular location: cytosol

PUT
type: Complex
component stoichiometry: PUT s43 sa23 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s43 sa23 161
cellular location: cytosol

TKV
type: ProteinReference
xref: P06300
standard name: thickveins
comment: ENTITY_REFERENCE_ID_DESC=GBB_signaling_pathway.PROTEIN.RECEPTOR.TKV
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Receptor protein serine/threonine kinase

PUT
type: Complex
component stoichiometry: PUT s77 sa51 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s77 sa51 187
cellular location: cytosol

MED/ phosphoMAD
type: Complex
component stoichiometry: MED s142 sa116 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 63STOICHIOMETRY ID COMPLEX
component: MED
component: MAD
feature: COMPLEX BINDING FEATURE s140 csa20 92
feature: COMPLEX BINDING FEATURE s140 csa20 94
cellular location: nucleus

TKV s8 sa10 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

SAX s17 sa15 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

GBB full length
type: Complex
component stoichiometry: GBB full length s48 sa29 STOICHIOMETRY ID COMPLEX
component: GBB full length
cellular location: Golgi apparatus

PARTICIPANT STOICHIOMETRY re14 291
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

phosphoSAX/ GBB/PUT
type: Complex
component stoichiometry: HOMODIMER ID 14STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 33STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 77STOICHIOMETRY ID COMPLEX
component: SAX
component: PUT
component: GBB
feature: COMPLEX BINDING FEATURE s39 csa7 164
feature: COMPLEX BINDING FEATURE s39 csa7 160
feature: COMPLEX BINDING FEATURE s39 csa7 162
cellular location: cytosol

phosphoSAX/ GBB/PUT MAD
type: Complex
component stoichiometry: HOMODIMER ID 34STOICHIOMETRY ID COMPLEX
component stoichiometry: MAD s76 sa54 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 82STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 15STOICHIOMETRY ID COMPLEX
component: PUT
component: SAX
component: GBB
component: MAD
feature: COMPLEX BINDING FEATURE s109 csa12 186
feature: COMPLEX BINDING FEATURE s109 csa12 192
feature: COMPLEX BINDING FEATURE s109 csa12 188
feature: COMPLEX BINDING FEATURE s109 csa12 190
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re14 292
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

TKV
type: Protein
entity reference: TKV
feature: TKV s28 sa21 rs1

uniprot A0A0B4K7J3 27
type: UnificationXref
id: A0A0B4K7J3
db: uniprot

? s52 sa33 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

LACK
type: ProteinReference
xref: P06303
standard name: lethal with a checkpoint kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=GBB_signaling_pathway.PROTEIN.GENERIC.LACK
comment: ENTITY_REFERENCE_NOTES=
member entity reference: E3 ubiquitin-protein ligase Smurf1

SAX s24 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

SAX
type: Protein
entity reference: SAX
feature: SAX s24 sa19 rs1

TRANSPORT_LEFT__MED__phosphoMAD-RIGHT__MED__phosphoMAD-_re42
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 306
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 307
left: MED/ phosphoMAD
interaction type: TRANSPORT
right: MED/ phosphoMAD

WIT s5 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION_LEFT__GBB-_SAX-RIGHT__GBB__SAX-_re2
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 267
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 265
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 266
left: GBB
left: SAX
interaction type: HETERODIMER_ASSOCIATION
right: GBB/ SAX

GBB full length s48 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB full length
stoichiometric coefficient: 2.0

00696
type: UnificationXref
id: MOD:00696
db: mod

PARTICIPANT STOICHIOMETRY re22 241
type: Stoichiometry
physical entity: phosphoTKV/ GBB/WIT
stoichiometric coefficient: 1.0

WIT
type: Protein
entity reference: WIT

PARTICIPANT STOICHIOMETRY re22 242
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re22 243
type: Stoichiometry
physical entity: phosphoTKV/ GBB/WIT MAD
stoichiometric coefficient: 1.0

GBB
type: ProteinReference
xref: P06294
standard name: glass bottom boat
comment: ENTITY_REFERENCE_ID_DESC=GBB_signaling_pathway.PROTEIN.TRUNCATED.GBB
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein 60A

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 8

HOMODIMER ID 51STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

GBB s14 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

?
type: Protein

SAX s115 sa111 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NEJ
stoichiometric coefficient: 1.0

SAX s11 sa4 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

MAD s76 sa54 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

uniprot M9MS40 25
type: UnificationXref
id: M9MS40
db: uniprot

HOMODIMER ID 15STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

MAD s112 sa79 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__phosphoMAD_LACK-RIGHT__phosphoMAD_LACK-_re46
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re46 290
participant stoichiometry: PARTICIPANT STOICHIOMETRY re46 289
left: phosphoMAD LACK
interaction type: STATE_TRANSITION
right: phosphoMAD LACK

GBB/ TKV
type: Complex
component stoichiometry: HOMODIMER ID 43STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 78STOICHIOMETRY ID COMPLEX
component: GBB
component: TKV
feature: COMPLEX BINDING FEATURE s2 csa1 110
feature: COMPLEX BINDING FEATURE s2 csa1 112
cellular location: cytosol

TKV
type: Protein
entity reference: TKV
feature: TKV s121 sa69 rs1

MED
type: Protein
entity reference: MED
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__PUT-RIGHT__PUT-_re21
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 249
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 248
left: PUT
interaction type: TRANSPORT
right: PUT

PTHR23255:SF98
type: RelationshipXref
id: PTHR23255:SF98
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: RelationshipTypeVocabulary

GBB s44 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

uniprot Q9V853 17
type: UnificationXref
id: Q9V853
db: uniprot

TKV s61 sa42 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

SAX s32 sa24 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

SAX
type: Protein
entity reference: SAX
feature: SAX s82 sa28 rs1

MAD s155 sa121 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

WIT s58 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF68
xref: uniprot Q9VMT1 39
organism: Drosophila melanogaster

TKV s62 sa43 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

? s56 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

Protein mothers against dpp
type: ProteinReference
xref: uniprot P42003 22
xref: PTHR13703:SF61
organism: Drosophila melanogaster

NEJ
type: Protein
entity reference: NEJ
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

eco ECO:0000501 8
type: UnificationXref
id: ECO:0000501
db: eco

HOMODIMER ID 45STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re44 297
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re44 298
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PTHR11848:SF263
type: RelationshipXref
id: PTHR11848:SF263
db: PANTHER Family
relationship type: By Homology

MAD
type: Protein
entity reference: MAD
feature: MAD s76 sa54 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s76 sa54 193
feature: MAD s76 sa54 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__GBB-_TKV-RIGHT__GBB__TKV-_re1
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 270
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 268
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 269
left: GBB
left: TKV
interaction type: HETERODIMER_ASSOCIATION
right: GBB/ TKV

GBB
type: Protein
entity reference: GBB

PARTICIPANT STOICHIOMETRY re24 228
type: Stoichiometry
physical entity: phosphoSAX/ GBB/WIT
stoichiometric coefficient: 1.0

TKV s62 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re24 229
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__MED__phosphoMAD-_SHN-RIGHT__SHN_MED__phosphoMAD-_re36
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 318
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 316
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 317
left: MED/ phosphoMAD
left: SHN
interaction type: HETERODIMER_ASSOCIATION
right: SHN/MED/ phosphoMAD

GO GO:0005634 2
type: UnificationXref
id: GO:0005634
db: GO

GBB
type: Protein
entity reference: GBB

GBB s137 sa81 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

HOMODIMER ID 86STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

MAD s116 sa87 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

PARTICIPANT STOICHIOMETRY re18 274
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

?
type: Protein

phosphoSAX/ GBB/WIT phosphoMAD
type: Complex
component stoichiometry: HOMODIMER ID 58STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 38STOICHIOMETRY ID COMPLEX
component stoichiometry: MAD s112 sa79 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 87STOICHIOMETRY ID COMPLEX
component: WIT
component: SAX
component: MAD
component: GBB
feature: COMPLEX BINDING FEATURE s111 csa16 212
feature: COMPLEX BINDING FEATURE s111 csa16 210
feature: COMPLEX BINDING FEATURE s111 csa16 214
feature: COMPLEX BINDING FEATURE s111 csa16 208
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re18 273
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 1.0

Evidence 9
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0003169.html

SAX s104 sa74 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

LACK
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s114 sa124 127
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MAD s113 sa109 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

NEJ/MED/ phosphoMAD
type: Complex
component stoichiometry: SAX s115 sa111 STOICHIOMETRY ID COMPLEX
component stoichiometry: MED s152 sa110 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 61STOICHIOMETRY ID COMPLEX
component: MAD
component: MED
component: NEJ
feature: COMPLEX BINDING FEATURE s124 csa18 96
feature: COMPLEX BINDING FEATURE s124 csa18 98
feature: COMPLEX BINDING FEATURE s124 csa18 100
cellular location: nucleus

STATE_TRANSITION
type: RelationshipTypeVocabulary

MAD
type: Protein
entity reference: MAD
feature: MAD s117 sa90 rs2
feature: MAD s117 sa90 rs1

HOMODIMER ID 83STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

P06305
type: UnificationXref
id: P06305
db: PANTHER Pathway Component

P06306
type: UnificationXref
id: P06306
db: PANTHER Pathway Component

P06303
type: UnificationXref
id: P06303
db: PANTHER Pathway Component

P06304
type: UnificationXref
id: P06304
db: PANTHER Pathway Component

P06300
type: UnificationXref
id: P06300
db: PANTHER Pathway Component

MAD s106 sa76 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

TKV
type: Protein
entity reference: TKV
feature: TKV s1 sa1 rs1

HOMODIMER ID 43STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

NEJ
type: Protein
entity reference: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s115 sa111 101
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PUT
type: Protein
entity reference: PUT

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 21
xref: PTHR13703:SF45
xref: uniprot O62609 20
organism: Drosophila melanogaster

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s134 sa113 169
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

NEJ
type: ProteinReference
xref: P06295
standard name: nejire
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=GBB_signaling_pathway.PROTEIN.GENERIC.NEJ
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Nejire, isoform C

MED
type: ProteinReference
xref: P06299
standard name: medea
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=GBB_signaling_pathway.PROTEIN.GENERIC.MED
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein mothers against dpp
member entity reference: Mothers against decapentaplegic homolog

HOMODIMER ID 34STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

SAX s86 sa60 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

MED
type: Protein
entity reference: TKV
feature: COMPLEX PARTICIPANT BINDING FEATURE s96 sa93 91
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__phosphoSAX__GBB_PUT-_MAD-RIGHT__phosphoSAX__GBB_PUT_MAD-_re23
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 234
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 235
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 236
left: phosphoSAX/ GBB/PUT
left: MAD
interaction type: HETERODIMER_ASSOCIATION
right: phosphoSAX/ GBB/PUT MAD

PARTICIPANT STOICHIOMETRY re16 282
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 283
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

P06307
type: UnificationXref
id: P06307
db: PANTHER Pathway Component

PUT s63 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

Serine/threonine-protein kinase receptor
type: ProteinReference
evidence: Evidence 9
xref: uniprot A0A0B4KG59 6
xref: PTHR23255:SF98
organism: Drosophila melanogaster

MAD s119 sa92 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

MAD
type: Protein
entity reference: MAD
feature: MAD s119 sa92 rs2
feature: MAD s119 sa92 rs1

phosphoTKV/ GBB/WIT phosphoMAD
type: Complex
component stoichiometry: HOMODIMER ID 57STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 47STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 85STOICHIOMETRY ID COMPLEX
component stoichiometry: MAD s98 sa67 STOICHIOMETRY ID COMPLEX
component: GBB
component: WIT
component: MAD
component: TKV
feature: COMPLEX BINDING FEATURE s99 csa14 140
feature: COMPLEX BINDING FEATURE s99 csa14 146
feature: COMPLEX BINDING FEATURE s99 csa14 144
feature: COMPLEX BINDING FEATURE s99 csa14 142
cellular location: cytosol

MAD s113 sa109 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re30 332
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re30 331
type: Stoichiometry
physical entity: phosphoSAX/ GBB/WIT phosphoMAD
stoichiometric coefficient: 1.0

MED s114 sa124 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re30 333
type: Stoichiometry
physical entity: phosphoSAX/ GBB/WIT
stoichiometric coefficient: 1.0

HOMODIMER ID 74STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

?
type: Protein

HOMODIMER ID 61STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

MAD s116 sa87 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

GBB
type: Protein
entity reference: GBB

WIT
type: Protein
entity reference: WIT

Target transcripts
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

PARTICIPANT STOICHIOMETRY re15 287
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__TKV-RIGHT__TKV-_re18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 274
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 273
left: TKV
interaction type: STATE_TRANSITION
right: TKV

GO GO:0005829 5
type: UnificationXref
id: GO:0005829
db: GO

WIT
type: Protein
entity reference: WIT

PARTICIPANT STOICHIOMETRY re20 255
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re15 288
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

HOMODIMER ID 73STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

SAX
type: Protein
entity reference: SAX
feature: SAX s32 sa24 rs1

PUT
type: ProteinReference
xref: P06304
standard name: punt
comment: ENTITY_REFERENCE_ID_DESC=GBB_signaling_pathway.PROTEIN.RECEPTOR.PUT
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Serine/threonine-protein kinase receptor

PARTICIPANT STOICHIOMETRY re20 254
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 1.0

HOMODIMER ID 53STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

MAD s113 sa109 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re43 301
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

sa105_degraded
type: PhysicalEntity
cellular location: cytosol
comment: SPECIES_TYPE=DEGRADED

PARTICIPANT STOICHIOMETRY re43 302
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

TKV s96 sa93 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

TKV s121 sa69 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re2 266
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re2 267
type: Stoichiometry
physical entity: GBB/ SAX
stoichiometric coefficient: 1.0

MAD
type: Protein
entity reference: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s98 sa67 141
feature: MAD s98 sa67 rs2
feature: MAD s98 sa67 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR11254:SF395
type: RelationshipXref
id: PTHR11254:SF395
db: PANTHER Family
relationship type: By Homology

GBB s9 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__WIT-RIGHT__WIT-_re13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 296
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 295
left: WIT
interaction type: STATE_TRANSITION
right: WIT

STATE_TRANSITION_LEFT__WIT-RIGHT__WIT-_re12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 300
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 299
left: WIT
interaction type: STATE_TRANSITION
right: WIT

phosphoTKV/ GBB/WIT
type: Complex
component stoichiometry: HOMODIMER ID 45STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 53STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 76STOICHIOMETRY ID COMPLEX
component: WIT
component: GBB
component: TKV
feature: COMPLEX BINDING FEATURE s40 csa6 120
feature: COMPLEX BINDING FEATURE s40 csa6 122
feature: COMPLEX BINDING FEATURE s40 csa6 118
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re8 240
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

TRANSPORT
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re2 265
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

TKV
type: Protein
entity reference: TKV
feature: TKV s61 sa42 rs1
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

phosphoSAX/ GBB/WIT MAD
type: Complex
component stoichiometry: HOMODIMER ID 56STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 84STOICHIOMETRY ID COMPLEX
component stoichiometry: MAD s87 sa56 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 36STOICHIOMETRY ID COMPLEX
component: GBB
component: MAD
component: WIT
component: SAX
feature: COMPLEX BINDING FEATURE s110 csa13 132
feature: COMPLEX BINDING FEATURE s110 csa13 138
feature: COMPLEX BINDING FEATURE s110 csa13 134
feature: COMPLEX BINDING FEATURE s110 csa13 136
cellular location: cytosol

SAX s138 sa82 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

MAD
type: Protein
entity reference: MAD
feature: MAD s126 sa112 rs1
feature: MAD s126 sa112 rs2

MAD s156 sa118 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

PUT s45 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

TKV
type: Protein
entity reference: TKV
feature: TKV s8 sa10 rs1

TKV
type: Protein
entity reference: TKV
feature: TKV s62 sa43 rs1

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s152 sa110 99
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

GBB
type: Protein
entity reference: GBB

PARTICIPANT STOICHIOMETRY re3 262
type: Stoichiometry
physical entity: GBB/ TKV
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 263
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re3 264
type: Stoichiometry
physical entity: TKV/GBB/ WIT
stoichiometric coefficient: 1.0

LACK
type: Protein
entity reference: LACK
feature: COMPLEX PARTICIPANT BINDING FEATURE s154 sa122 131
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SAX
type: Protein
entity reference: SAX
feature: SAX s74 sa52 rs1

MAD s151 sa123 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

GBB s10 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

PUT s43 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

HOMODIMER ID 16STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

SAX
type: Protein
entity reference: SAX
feature: SAX s104 sa74 rs1

SAX s74 sa52 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phosphoMAD_LACK-RIGHT__phosphoMAD_LACK-_re46
controller: LACK

uniprot P26016 64
type: UnificationXref
id: P26016
db: uniprot

PARTICIPANT STOICHIOMETRY re24 230
type: Stoichiometry
physical entity: phosphoSAX/ GBB/WIT MAD
stoichiometric coefficient: 1.0

HOMODIMER ID 57STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

MAD s151 sa123 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

GBB
type: Protein
entity reference: GBB

HOMODIMER ID 78STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

GBB
type: Protein
entity reference: GBB

Evidence 21
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0011655.html

HOMODIMER ID 80STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__ATP-_SAX-RIGHT__ADP-_SAX-_re8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 238
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 237
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 240
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 239
left: SAX
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: SAX

phosphoSAX/ GBB/PUT phosphoMAD
type: Complex
component stoichiometry: HOMODIMER ID 37STOICHIOMETRY ID COMPLEX
component stoichiometry: MAD s106 sa76 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 86STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 16STOICHIOMETRY ID COMPLEX
component: SAX
component: PUT
component: GBB
component: MAD
feature: COMPLEX BINDING FEATURE s108 csa15 184
feature: COMPLEX BINDING FEATURE s108 csa15 180
feature: COMPLEX BINDING FEATURE s108 csa15 178
feature: COMPLEX BINDING FEATURE s108 csa15 182
cellular location: cytosol

PDP
type: Protein
entity reference: PDP
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

HOMODIMER ID 30STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

MAD
type: Protein
entity reference: MAD
feature: MAD s65 sa46 rs2
feature: MAD s65 sa46 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__ATP-_SAX_GBB__PUT-RIGHT__ADP-_phosphoSAX__GBB_PUT-_re7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 246
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 247
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 245
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 244
left: ATP
left: SAX/GBB/ PUT
interaction type: STATE_TRANSITION
right: phosphoSAX/ GBB/PUT
right: ADP

SAX s138 sa82 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

PARTICIPANT STOICHIOMETRY re10 309
type: Stoichiometry
physical entity: proGBB
stoichiometric coefficient: 1.0

SHN/MED/ phosphoMAD
type: Complex
component stoichiometry: SHN s139 sa114 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 62STOICHIOMETRY ID COMPLEX
component stoichiometry: MED s134 sa113 STOICHIOMETRY ID COMPLEX
component: MED
component: SHN
component: MAD
feature: COMPLEX BINDING FEATURE s125 csa19 170
feature: COMPLEX BINDING FEATURE s125 csa19 168
feature: COMPLEX BINDING FEATURE s125 csa19 166
cellular location: nucleus

PTHR13808:SF1
type: RelationshipXref
id: PTHR13808:SF1
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re10 308
type: Stoichiometry
physical entity: proGBB
stoichiometric coefficient: 1.0

HOMODIMER ID 68STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

phosphoTKV/ GBB/WIT MAD
type: Complex
component stoichiometry: MAD s67 sa47 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 81STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 46STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 54STOICHIOMETRY ID COMPLEX
component: TKV
component: GBB
component: WIT
component: MAD
feature: COMPLEX BINDING FEATURE s71 csa11 106
feature: COMPLEX BINDING FEATURE s71 csa11 108
feature: COMPLEX BINDING FEATURE s71 csa11 104
feature: COMPLEX BINDING FEATURE s71 csa11 102
cellular location: cytosol

MAD s98 sa67 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

MAD
type: Protein
entity reference: MAD
feature: MAD s113 sa109 rs2
feature: MAD s113 sa109 rs1

GBB s42 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

TKV s69 sa49 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

Evidence 18
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0029006.html

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__MED__phosphoMAD-RIGHT__MED-_MAD-_re41
controller: PPM1A

GBB/ SAX
type: Complex
component stoichiometry: HOMODIMER ID 30STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 73STOICHIOMETRY ID COMPLEX
component: SAX
component: GBB
feature: COMPLEX BINDING FEATURE s12 csa3 116
feature: COMPLEX BINDING FEATURE s12 csa3 114
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re46 290
type: Stoichiometry
physical entity: phosphoMAD LACK
stoichiometric coefficient: 1.0

MAD s117 sa90 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 3.0

WIT
type: ProteinReference
xref: P06306
standard name: wishful thinking
comment: ENTITY_REFERENCE_ID_DESC=GBB_signaling_pathway.PROTEIN.RECEPTOR.WIT
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Receptor protein serine/threonine kinase

PTHR23255:SF63
type: RelationshipXref
id: PTHR23255:SF63
db: PANTHER Family
relationship type: By Homology

TRANSPORT_LEFT__MED-RIGHT__MED-_re43
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 301
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 302
left: MED
interaction type: TRANSPORT
right: MED

PTHR23255:SF68
type: RelationshipXref
id: PTHR23255:SF68
db: PANTHER Family
relationship type: By Homology

GBB s51 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

MAD
type: Protein
entity reference: MAD
feature: MAD s151 sa123 rs1
feature: MAD s151 sa123 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s151 sa123 125
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HOMODIMER ID 35STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION_LEFT__MAD-_LACK-RIGHT__phosphoMAD_LACK-_re49
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re49 276
participant stoichiometry: PARTICIPANT STOICHIOMETRY re49 277
participant stoichiometry: PARTICIPANT STOICHIOMETRY re49 275
left: LACK
left: MAD
interaction type: HETERODIMER_ASSOCIATION
right: phosphoMAD LACK

GBB s81 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

MAD s126 sa112 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

DISSOCIATION_LEFT__phosphoSAX__GBB_WIT_phosphoMAD-RIGHT__MAD-_phosphoSAX__GBB_WIT-_re30
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 332
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 331
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 333
left: phosphoSAX/ GBB/WIT phosphoMAD
interaction type: DISSOCIATION
right: phosphoSAX/ GBB/WIT
right: MAD

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_SAX-RIGHT__ADP-_SAX-_re8
controller: WIT

WIT s46 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re47 284
type: Stoichiometry
physical entity: phosphoMAD LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re47 285
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re47 286
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

SAX s59 sa40 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

SAX
type: Protein
entity reference: SAX
feature: SAX s138 sa82 rs1

uniprot A0A0B4KG59 6
type: UnificationXref
id: A0A0B4KG59
db: uniprot

PTHR23255:SF72
type: RelationshipXref
id: PTHR23255:SF72
db: PANTHER Family
relationship type: By Homology

MAD s155 sa121 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MED s134 sa113 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

DISSOCIATION
type: InteractionVocabulary

MAD s141 sa115 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

SHN s139 sa114 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SHN
stoichiometric coefficient: 1.0

HOMODIMER ID 79STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

PUT s103 sa73 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PANTHER Pathway P06214 1
type: UnificationXref
id: P06214
db: PANTHER Pathway

HOMODIMER ID 52STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

PUT s77 sa51 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PPM1A
type: Protein
entity reference: PPM1A
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

TKV s69 sa49 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

GBB s23 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

eco ECO:0000316 26
type: UnificationXref
id: ECO:0000316
db: eco

PARTICIPANT STOICHIOMETRY re4 261
type: Stoichiometry
physical entity: SAX/GBB/ WIT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 260
type: Stoichiometry
physical entity: GBB/ SAX
stoichiometric coefficient: 1.0

HOMODIMER ID 36STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

SAX s59 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

HOMODIMER ID 32STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

TKV s3 sa7 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

MAD s87 sa56 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MAD s141 sa115 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR42884:SF3
type: RelationshipXref
id: PTHR42884:SF3
db: PANTHER Family
relationship type: By Homology

SAX s86 sa60 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re17 278
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re4 259
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

uniprot Q9W3Q1 23
type: UnificationXref
id: Q9W3Q1
db: uniprot

HOMODIMER ID 38STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

PUT
type: Protein
entity reference: PUT

PUT
type: Protein
entity reference: PUT

WIT s7 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

HOMODIMER ID 81STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

MAD s141 sa115 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

GBB
type: Protein
entity reference: GBB

? s54 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

MAD s65 sa46 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re17 279
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re45 294
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re45 293
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

HOMODIMER ID 58STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

Protein 60A
type: ProteinReference
xref: PTHR11848:SF263
xref: uniprot P27091 70
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re27 216
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 2.0

TKV
type: Protein
entity reference: TKV
feature: TKV s69 sa49 rs1

PARTICIPANT STOICHIOMETRY re27 217
type: Stoichiometry
physical entity: phosphoSAX/ GBB/WIT MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re27 218
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re27 219
type: Stoichiometry
physical entity: phosphoSAX/ GBB/WIT phosphoMAD
stoichiometric coefficient: 1.0

TKV s28 sa21 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

MAD s87 sa56 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

STATE_TRANSITION_LEFT__ATP-_phosphoTKV__GBB_WIT_MAD-RIGHT__ADP-_phosphoTKV__GBB_WIT_phosphoMAD-_re25
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 225
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 227
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 226
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 224
left: phosphoTKV/ GBB/WIT MAD
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: phosphoTKV/ GBB/WIT phosphoMAD

MAD s156 sa118 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

TRANSPORT_LEFT__SAX-RIGHT__SAX-_re17
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 279
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 278
left: SAX
interaction type: TRANSPORT
right: SAX

PARTICIPANT STOICHIOMETRY re8 239
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 10.0

MAD
type: Protein
entity reference: MAD
feature: MAD s67 sa47 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s67 sa47 103
feature: MAD s67 sa47 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re8 238
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re8 237
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 10.0

STATE_TRANSITION_LEFT__ATP-_phosphoSAX__GBB_WIT_MAD-RIGHT__ADP-_phosphoSAX__GBB_WIT_phosphoMAD-_re27
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 219
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 216
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 217
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 218
left: phosphoSAX/ GBB/WIT MAD
left: ATP
interaction type: STATE_TRANSITION
right: phosphoSAX/ GBB/WIT phosphoMAD
right: ADP

MED s152 sa110 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

WIT s84 sa58 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

MAD s65 sa46 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

GBB
type: Protein
entity reference: GBB

PARTICIPANT STOICHIOMETRY re19 272
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re19 271
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_phosphoTKV__GBB_WIT_MAD-RIGHT__ADP-_phosphoTKV__GBB_WIT_phosphoMAD-_re25
controller: TKV

TRUNCATION_LEFT__GBB_full_length-RIGHT__?-_GBB-_re9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 231
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 233
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 232
left: GBB full length
interaction type: TRUNCATION
right: GBB
right: ?

SAX
type: ProteinReference
xref: P06307
standard name: saxophone
comment: ENTITY_REFERENCE_ID_DESC=GBB_signaling_pathway.PROTEIN.RECEPTOR.SAX
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Receptor protein serine/threonine kinase

STATE_TRANSITION_LEFT__MAD-RIGHT__sa105_degraded-_re48
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re48 281
participant stoichiometry: PARTICIPANT STOICHIOMETRY re48 280
left: MAD
interaction type: STATE_TRANSITION
right: sa105_degraded

IDA
type: EvidenceCodeVocabulary

GBB
type: Protein
entity reference: GBB

TKV s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

SAX s82 sa28 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re31 330
type: Stoichiometry
physical entity: phosphoSAX/ GBB/PUT
stoichiometric coefficient: 1.0

PUT s30 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

SAX s104 sa74 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

ncbitaxon 7227 7
type: UnificationXref
id: 7227
db: ncbitaxon

HOMODIMER ID 31STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

GO GO:0005783 3
type: UnificationXref
id: GO:0005783
db: GO

SAX/GBB/ WIT
type: Complex
component stoichiometry: HOMODIMER ID 52STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 75STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 32STOICHIOMETRY ID COMPLEX
component: GBB
component: SAX
component: WIT
feature: COMPLEX BINDING FEATURE s21 csa5 154
feature: COMPLEX BINDING FEATURE s21 csa5 156
feature: COMPLEX BINDING FEATURE s21 csa5 158
cellular location: cytosol

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Furin-like protease 1, isoforms 1/1-X/2
type: ProteinReference
xref: uniprot P26016 64
xref: PTHR42884:SF3
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__PUT-RIGHT__PUT-_re20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 254
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 255
left: PUT
interaction type: STATE_TRANSITION
right: PUT

SHN
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s139 sa114 171
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot M9PE88 48
type: UnificationXref
id: M9PE88
db: uniprot

TRANSPORT_LEFT__WIT-RIGHT__WIT-_re15
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 287
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 288
left: WIT
interaction type: TRANSPORT
right: WIT

TRANSPORT_LEFT__WIT-RIGHT__WIT-_re14
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 291
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 292
left: WIT
interaction type: TRANSPORT
right: WIT

PARTICIPANT STOICHIOMETRY re31 328
type: Stoichiometry
physical entity: phosphoSAX/ GBB/PUT phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re31 329
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 40

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_TKV-RIGHT__ADP-_TKV-_re6
controller: WIT

MAD
type: Protein
entity reference: MAD
feature: MAD s87 sa56 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s87 sa56 133
feature: MAD s87 sa56 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P27091 70
type: UnificationXref
id: P27091
db: uniprot

PARTICIPANT STOICHIOMETRY re6 250
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 8.0

HOMODIMER ID 44STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF72
xref: uniprot A0A0B4K7J3 27
organism: Drosophila melanogaster

FUR1
type: ProteinReference
xref: P06298
standard name: furin 1
comment: ENTITY_REFERENCE_ID_DESC=GBB_signaling_pathway.PROTEIN.GENERIC.FUR1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Furin-like protease 1, isoforms 1/1-X/2

HOMODIMER ID 55STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

TKV s1 sa1 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re7 247
type: Stoichiometry
physical entity: phosphoSAX/ GBB/PUT
stoichiometric coefficient: 1.0

SAX s13 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION_LEFT__WIT-_GBB__SAX-RIGHT__SAX_GBB__WIT-_re4
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 260
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 261
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 259
left: WIT
left: GBB/ SAX
interaction type: HETERODIMER_ASSOCIATION
right: SAX/GBB/ WIT

PARTICIPANT STOICHIOMETRY re7 245
type: Stoichiometry
physical entity: SAX/GBB/ PUT
stoichiometric coefficient: 1.0

By Homology
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re7 246
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 10.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_phosphoSAX__GBB_PUT_MAD-RIGHT__ADP-_phosphoSAX__GBB_PUT_phosphoMAD-_re26
controller: SAX

PARTICIPANT STOICHIOMETRY re7 244
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 10.0

PARTICIPANT STOICHIOMETRY re6 252
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 8.0

PARTICIPANT STOICHIOMETRY re6 251
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

HOMODIMER ID 63STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re6 253
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

P06299
type: UnificationXref
id: P06299
db: PANTHER Pathway Component

MAD s155 sa121 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

SAX s82 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

P06294
type: UnificationXref
id: P06294
db: PANTHER Pathway Component

P06296
type: UnificationXref
id: P06296
db: PANTHER Pathway Component

DISSOCIATION_LEFT__phosphoSAX__GBB_PUT_phosphoMAD-RIGHT__MAD-_phosphoSAX__GBB_PUT-_re31
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 330
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 328
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 329
left: phosphoSAX/ GBB/PUT phosphoMAD
interaction type: DISSOCIATION
right: phosphoSAX/ GBB/PUT
right: MAD

STATE_TRANSITION_LEFT__ATP-_phosphoSAX__GBB_PUT_MAD-RIGHT__ADP-_phosphoSAX__GBB_PUT_phosphoMAD-_re26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 223
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 221
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 222
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 220
left: ATP
left: phosphoSAX/ GBB/PUT MAD
interaction type: STATE_TRANSITION
right: ADP
right: phosphoSAX/ GBB/PUT phosphoMAD

P06295
type: UnificationXref
id: P06295
db: PANTHER Pathway Component

P06298
type: UnificationXref
id: P06298
db: PANTHER Pathway Component

P06297
type: UnificationXref
id: P06297
db: PANTHER Pathway Component

TRANSPORT_LEFT__TKV-RIGHT__TKV-_re19
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 272
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 271
left: TKV
interaction type: TRANSPORT
right: TKV

FUR1
type: Protein
entity reference: FUR1
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__MAD-RIGHT__MAD-_re33
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 323
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 324
left: MAD
interaction type: STATE_TRANSITION
right: MAD

HOMODIMER ID 85STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

WIT s68 sa48 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

HOMODIMER ID 60STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

MAD s67 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re46 289
type: Stoichiometry
physical entity: phosphoMAD LACK
stoichiometric coefficient: 1.0

HOMODIMER ID 47STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

proGBB
type: Complex
component stoichiometry: HOMODIMER ID 79STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 68STOICHIOMETRY ID COMPLEX
component: GBB
component: ?
feature: COMPLEX BINDING FEATURE s50 csa9 200
feature: COMPLEX BINDING FEATURE s50 csa9 202
cellular location: Golgi apparatus

GBB
type: Complex
component stoichiometry: GBB s85 sa59 STOICHIOMETRY ID COMPLEX
component: GBB
feature: COMPLEX PARTICIPANT BINDING FEATURE s85 sa59 137
cellular location: cytosol

GBB
type: Complex
component stoichiometry: GBB s81 sa27 STOICHIOMETRY ID COMPLEX
component: GBB
feature: COMPLEX PARTICIPANT BINDING FEATURE s81 sa27 151
cellular location: cytosol

MAD
type: Protein
entity reference: MAD
feature: MAD s156 sa118 rs2
feature: MAD s156 sa118 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MAD s76 sa54 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

GBB
type: Complex
component stoichiometry: GBB s105 sa75 STOICHIOMETRY ID COMPLEX
component: GBB
feature: COMPLEX PARTICIPANT BINDING FEATURE s105 sa75 183
cellular location: cytosol

GBB
type: Complex
component stoichiometry: GBB s97 sa70 STOICHIOMETRY ID COMPLEX
component: GBB
feature: COMPLEX PARTICIPANT BINDING FEATURE s97 sa70 147
cellular location: cytosol

GBB
type: Complex
component stoichiometry: GBB s137 sa81 STOICHIOMETRY ID COMPLEX
component: GBB
feature: COMPLEX PARTICIPANT BINDING FEATURE s137 sa81 213
cellular location: cytosol

GBB_signaling_pathway
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__NEJ-_MED__phosphoMAD-RIGHT__NEJ_MED__phosphoMAD-_re37
pathway component: STATE_TRANSITION_LEFT__WIT-RIGHT__WIT-_re13
pathway component: STATE_TRANSITION_LEFT__ATP-_SAX_GBB__PUT-RIGHT__ADP-_phosphoSAX__GBB_PUT-_re7
pathway component: DISSOCIATION_LEFT__phosphoMAD_LACK-RIGHT__MAD-_LACK-_re47
pathway component: DISSOCIATION_LEFT__proGBB-RIGHT__?-_GBB-_re11
pathway component: TRANSPORT_LEFT__MED-RIGHT__MED-_re43
pathway component: STATE_TRANSITION_LEFT__SAX-RIGHT__SAX-_re16
pathway component: TRANSPORT_LEFT__SAX-RIGHT__SAX-_re17
pathway component: HETERODIMER_ASSOCIATION_LEFT__phosphoTKV__GBB_WIT-_MAD-RIGHT__phosphoTKV__GBB_WIT_MAD-_re22
pathway component: HETERODIMER_ASSOCIATION_LEFT__phosphoSAX__GBB_WIT-_MAD-RIGHT__phosphoSAX__GBB_WIT_MAD-_re24
pathway component: HETERODIMER_ASSOCIATION_LEFT__GBB__TKV-_WIT-RIGHT__TKV_GBB__WIT-_re3
pathway component: STATE_TRANSITION_LEFT__ATP-_TKV-RIGHT__ADP-_TKV-_re6
pathway component: HETERODIMER_ASSOCIATION_LEFT__MED__phosphoMAD-_SHN-RIGHT__SHN_MED__phosphoMAD-_re36
pathway component: TRANSPORT_LEFT__MED__phosphoMAD-RIGHT__MED__phosphoMAD-_re42
pathway component: HETERODIMER_ASSOCIATION_LEFT__PUT-_GBB__SAX-RIGHT__SAX_GBB__PUT-_re5
pathway component: HETERODIMER_ASSOCIATION_LEFT__GBB-_SAX-RIGHT__GBB__SAX-_re2
pathway component: DISSOCIATION_LEFT__phosphoSAX__GBB_PUT_phosphoMAD-RIGHT__MAD-_phosphoSAX__GBB_PUT-_re31
pathway component: TRANSPORT_LEFT__proGBB-RIGHT__proGBB-_re10
pathway component: STATE_TRANSITION_LEFT__ATP-_phosphoSAX__GBB_PUT_MAD-RIGHT__ADP-_phosphoSAX__GBB_PUT_phosphoMAD-_re26
pathway component: TRANSPORT_LEFT__TKV-RIGHT__TKV-_re19
pathway component: STATE_TRANSITION_LEFT__TKV-RIGHT__TKV-_re18
pathway component: DISSOCIATION_LEFT__phosphoSAX__GBB_WIT_phosphoMAD-RIGHT__MAD-_phosphoSAX__GBB_WIT-_re30
pathway component: STATE_TRANSITION_LEFT__phosphoMAD_LACK-RIGHT__phosphoMAD_LACK-_re46
pathway component: STATE_TRANSITION_LEFT__ATP-_SAX-RIGHT__ADP-_SAX-_re8
pathway component: HETERODIMER_ASSOCIATION_LEFT__phosphoSAX__GBB_PUT-_MAD-RIGHT__phosphoSAX__GBB_PUT_MAD-_re23
pathway component: HETERODIMER_ASSOCIATION_LEFT__MAD-_LACK-RIGHT__phosphoMAD_LACK-_re49
pathway component: TRANSPORT_LEFT__PUT-RIGHT__PUT-_re21
pathway component: STATE_TRANSITION_LEFT__MAD-RIGHT__sa105_degraded-_re48
pathway component: TRANSPORT_LEFT__MAD-RIGHT__MAD-_re44
pathway component: STATE_TRANSITION_LEFT__MAD-RIGHT__MAD-_re33
pathway component: TRANSPORT_LEFT__MAD-RIGHT__MAD-_re45
pathway component: STATE_TRANSITION_LEFT__ATP-_phosphoTKV__GBB_WIT_MAD-RIGHT__ADP-_phosphoTKV__GBB_WIT_phosphoMAD-_re25
pathway component: TRANSPORT_LEFT__WIT-RIGHT__WIT-_re14
pathway component: HETERODIMER_ASSOCIATION_LEFT__GBB-_TKV-RIGHT__GBB__TKV-_re1
pathway component: DISSOCIATION_LEFT__MED__phosphoMAD-RIGHT__MED-_MAD-_re41
pathway component: STATE_TRANSITION_LEFT__WIT-RIGHT__WIT-_re12
pathway component: STATE_TRANSITION_LEFT__PUT-RIGHT__PUT-_re20
pathway component: STATE_TRANSITION_LEFT__MED-_MAD-RIGHT__MED__phosphoMAD-_MAD-_re34
pathway component: TRUNCATION_LEFT__GBB_full_length-RIGHT__?-_GBB-_re9
pathway component: DISSOCIATION_LEFT__phosphoTKV__GBB_WIT_phosphoMAD-RIGHT__MAD-_phosphoTKV__GBB_WIT-_re32
pathway component: HETERODIMER_ASSOCIATION_LEFT__WIT-_GBB__SAX-RIGHT__SAX_GBB__WIT-_re4
pathway component: STATE_TRANSITION_LEFT__ATP-_phosphoSAX__GBB_WIT_MAD-RIGHT__ADP-_phosphoSAX__GBB_WIT_phosphoMAD-_re27
pathway component: TRANSPORT_LEFT__WIT-RIGHT__WIT-_re15
xref: PANTHER Pathway P06214 1
comment: MODEL_NOTES=

SAX
type: Protein
entity reference: SAX
feature: SAX s60 sa41 rs1
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

Nejire, isoform C
type: ProteinReference
xref: PTHR13808:SF1
xref: uniprot M9MS40 25
organism: Drosophila melanogaster

STATE_TRANSITION
type: InteractionVocabulary

PUT
type: Protein
entity reference: PUT

GM14286p
type: ProteinReference
xref: uniprot Q9W3Q1 23
xref: PTHR13832:SF571
organism: Drosophila melanogaster

MAD s117 sa90 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

GBB
type: Complex
component stoichiometry: GBB s55 sa35 STOICHIOMETRY ID COMPLEX
component: GBB
feature: COMPLEX PARTICIPANT BINDING FEATURE s55 sa35 207

TRANSPORT
type: InteractionVocabulary

GBB
type: Complex
component stoichiometry: GBB s75 sa53 STOICHIOMETRY ID COMPLEX
component: GBB
feature: COMPLEX PARTICIPANT BINDING FEATURE s75 sa53 191
cellular location: cytosol

GBB
type: Complex
component stoichiometry: GBB s70 sa50 STOICHIOMETRY ID COMPLEX
component: GBB
feature: COMPLEX PARTICIPANT BINDING FEATURE s70 sa50 109
cellular location: cytosol

TKV s8 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

TRUNCATION
type: InteractionVocabulary

DISSOCIATION_LEFT__proGBB-RIGHT__?-_GBB-_re11
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 303
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 305
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 304
left: proGBB
interaction type: DISSOCIATION
right: GBB
right: ?

SAX s60 sa41 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

MAD s158 sa106 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

WIT
type: Protein
entity reference: WIT

MAD s67 sa47 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re33 323
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re41 310
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re33 324
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY re41 312
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re41 311
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

GBB
type: Protein
entity reference: GBB

MAD
type: Protein
entity reference: MAD
feature: MAD s158 sa106 rs1
feature: MAD s158 sa106 rs2
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

GBB
type: Protein
entity reference: GBB

PARTICIPANT STOICHIOMETRY re36 316
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__MAD-RIGHT__MAD-_re44
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re44 297
participant stoichiometry: PARTICIPANT STOICHIOMETRY re44 298
left: MAD
interaction type: TRANSPORT
right: MAD

PARTICIPANT STOICHIOMETRY re36 317
type: Stoichiometry
physical entity: SHN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re36 318
type: Stoichiometry
physical entity: SHN/MED/ phosphoMAD
stoichiometric coefficient: 1.0

WIT
type: Protein
entity reference: WIT
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

HOMODIMER ID 54STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

TRANSPORT_LEFT__MAD-RIGHT__MAD-_re45
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re45 294
participant stoichiometry: PARTICIPANT STOICHIOMETRY re45 293
left: MAD
interaction type: TRANSPORT
right: MAD

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s142 sa116 95
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

HOMODIMER ID 46STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

GBB s70 sa50 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

MAD s158 sa106 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

E3 ubiquitin-protein ligase Smurf1
type: ProteinReference
evidence: Evidence 18
xref: PTHR11254:SF395
xref: uniprot Q9V853 17
organism: Drosophila melanogaster

Evidence 66
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0086361.html

LACK
type: Protein
entity reference: LACK
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_SAX_GBB__PUT-RIGHT__ADP-_phosphoSAX__GBB_PUT-_re7
controller: PUT

WIT s136 sa80 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

TKV/GBB/ WIT
type: Complex
component stoichiometry: HOMODIMER ID 72STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 51STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 44STOICHIOMETRY ID COMPLEX
component: WIT
component: TKV
component: GBB
feature: COMPLEX BINDING FEATURE s6 csa2 196
feature: COMPLEX BINDING FEATURE s6 csa2 198
feature: COMPLEX BINDING FEATURE s6 csa2 194
cellular location: cytosol

GBB s97 sa70 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__SAX-RIGHT__SAX-_re16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 282
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 283
left: SAX
interaction type: STATE_TRANSITION
right: SAX

PARTICIPANT STOICHIOMETRY re25 227
type: Stoichiometry
physical entity: phosphoTKV/ GBB/WIT phosphoMAD
stoichiometric coefficient: 1.0

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 5

PARTICIPANT STOICHIOMETRY re25 225
type: Stoichiometry
physical entity: phosphoTKV/ GBB/WIT MAD
stoichiometric coefficient: 1.0

SAX s74 sa52 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re25 226
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 2.0

DISSOCIATION_LEFT__phosphoTKV__GBB_WIT_phosphoMAD-RIGHT__MAD-_phosphoTKV__GBB_WIT-_re32
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 326
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 327
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 325
left: phosphoTKV/ GBB/WIT phosphoMAD
interaction type: DISSOCIATION
right: MAD
right: phosphoTKV/ GBB/WIT

PARTICIPANT STOICHIOMETRY re25 224
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 2.0

HOMODIMER ID 69STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

HOMODIMER ID 37STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

HOMODIMER ID 75STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

DISSOCIATION_LEFT__MED__phosphoMAD-RIGHT__MED-_MAD-_re41
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 310
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 312
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 311
left: MED/ phosphoMAD
interaction type: DISSOCIATION
right: MED
right: MAD

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 26

PUT
type: Protein
entity reference: PUT

WIT
type: Protein
entity reference: WIT

uniprot Q9VMT1 39
type: UnificationXref
id: Q9VMT1
db: uniprot

PARTICIPANT STOICHIOMETRY re9 231
type: Stoichiometry
physical entity: GBB full length
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re9 232
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re9 233
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

HOMODIMER ID 76STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

uniprot O62609 20
type: UnificationXref
id: O62609
db: uniprot

TRANSPORT_LEFT__proGBB-RIGHT__proGBB-_re10
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 309
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 308
left: proGBB
interaction type: TRANSPORT
right: proGBB

GBB s105 sa75 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GBB
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__ATP-_TKV-RIGHT__ADP-_TKV-_re6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 251
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 253
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 250
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 252
left: ATP
left: TKV
interaction type: STATE_TRANSITION
right: ADP
right: TKV

eco ECO:0000304 40
type: UnificationXref
id: ECO:0000304
db: eco

HOMODIMER ID 33STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 2.0

MED
type: Protein
entity reference: MED
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__MED__phosphoMAD-RIGHT__MED-_MAD-_re41
controller: PDP

Alphabet, isoform E
type: ProteinReference
evidence: Evidence 66
xref: uniprot Q961C5 65
xref: PTHR47992:SF25
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re12 300
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0