RNA Polymerase I Complex
type: Protein
entity reference: RNA Polymerase I Complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s109 a95 248
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r20 279
type: Stoichiometry
physical entity: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
stoichiometric coefficient: 1.0

uniprot H2Q165 43
type: UnificationXref
id: H2Q165
db: uniprot

uniprot J9P923 123
type: UnificationXref
id: J9P923
db: uniprot

UCE s91 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: UCE
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-RIGHT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_re12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 310
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 311
left: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
interaction type: STATE_TRANSITION
right: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)

uniprot A6QLS0 46
type: UnificationXref
id: A6QLS0
db: uniprot

28S s56 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 28S
stoichiometric coefficient: 1.0

TATA box-binding protein-like protein 1
type: ProteinReference
xref: uniprot A6H914 82
xref: PTHR10126:SF55
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR15938:SF0
xref: uniprot E1BEL5 85
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r20 281
type: Stoichiometry
physical entity: TTF-I
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 280
type: Stoichiometry
physical entity: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
stoichiometric coefficient: 1.0

uniprot A7MAZ4 2
type: UnificationXref
id: A7MAZ4
db: uniprot

PARTICIPANT STOICHIOMETRY r20 283
type: Stoichiometry
physical entity: rRNA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 282
type: Stoichiometry
physical entity: RNA Polymerase I Complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 284
type: Stoichiometry
physical entity: PTRF
stoichiometric coefficient: 1.0

UBF1
type: Protein
entity reference: UBF1
comment: SPECIES_TYPE=PROTEIN

uniprot P28148 145
type: UnificationXref
id: P28148
db: uniprot

uniprot Q8TTZ7 104
type: UnificationXref
id: Q8TTZ7
db: uniprot

Homologous-pairing protein 2 homolog
type: ProteinReference
xref: PTHR15938:SF0
xref: uniprot Q9P2W1 110
organism: Homo sapiens

TATA-box-binding protein 2
type: ProteinReference
xref: uniprot Q8TU94 105
xref: PTHR10126:SF42
organism: Methanosarcina acetivorans

uniprot F7FMW4 54
type: UnificationXref
id: F7FMW4
db: uniprot

Promoter s149 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Promoter
stoichiometric coefficient: 1.0

rRNA
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s101 a92 234
comment: SPECIES_TYPE=RNA

18S s55 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 18S
stoichiometric coefficient: 1.0

Transcription initiation factor-like protein (TFIID-like protein)
type: ProteinReference
xref: uniprot Q4QD71 151
organism: Leishmania major

Mus musculus
type: BioSource
xref: ncbitaxon 10090 29

gene s150 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: gene
stoichiometric coefficient: 2.0

gene
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s93 sa10 222
comment: SPECIES_TYPE=GENE

General transcription by RNA polymerase I
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_PTRF-RIGHT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_re14
pathway component: STATE_TRANSITION_LEFT__UBF1-_Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-RIGHT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_re16
pathway component: UNKNOWN_TRANSITION_LEFT__TAF_IB-RIGHT__SL1_complex-_r8
pathway component: STATE_TRANSITION_LEFT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_TTF_I-RIGHT__UBF1-_Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_SL1_complex-_re13
pathway component: UNKNOWN_TRANSITION_LEFT__TAF_IC-RIGHT__SL1_complex-_r9
pathway component: STATE_TRANSITION_LEFT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-RIGHT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_re12
pathway component: STATE TRANSITION LEFT Complex UCE Promoter gene 18S gene 28S Terminator elements -RIGHT Complex UCE Promoter gene 18S gene 28S Terminator elements - TTF I- RNA Polymerase I Complex- rRNA- PTRF- r20
pathway component: STATE_TRANSITION_LEFT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_RNA_Polymerase_I__Complex-RIGHT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_r15
pathway component: UNKNOWN_TRANSITION_LEFT__TBP-RIGHT__SL1_complex-_r6
pathway component: UNKNOWN_TRANSITION_LEFT__TAF_IA-RIGHT__SL1_complex-_r7
pathway component: STATE_TRANSITION_LEFT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_SL1_complex-RIGHT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_r14
xref: PANTHER Pathway P00022 1
comment: MODEL_NOTES=Panther Pathway: P00022 Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes Medline=10672904 Medline=12865296 Medline=2014238 Medline=3413483 Medline=8921381 PMID: 10672904 PMID: 12865296 PMID: 2014238 PMID: 3413483 PMID: 8921381

PTHR46760:SF1
type: RelationshipXref
id: PTHR46760:SF1
db: PANTHER Family
relationship type: By Homology

uniprot P20227 142
type: UnificationXref
id: P20227
db: uniprot

UBF1
type: Protein
entity reference: UBF1
feature: COMPLEX PARTICIPANT BINDING FEATURE s66 a60 162
comment: SPECIES_TYPE=PROTEIN

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 66

uniprot P0DPB6 63
type: UnificationXref
id: P0DPB6
db: uniprot

PTHR32122:SF1
type: RelationshipXref
id: PTHR32122:SF1
db: PANTHER Family
relationship type: By Homology

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 39

Probable DNA-directed RNA polymerase I subunit RPA2
type: ProteinReference
xref: PTHR20856:SF5
xref: uniprot Q9P7X8 81
organism: Schizosaccharomyces pombe

gene s82 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: gene
stoichiometric coefficient: 2.0

DNA-directed RNA polymerase subunit beta
type: ProteinReference
xref: PTHR20856:SF5
xref: uniprot F6ZV36 52
organism: Xenopus tropicalis

Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
type: Complex
component stoichiometry: 18S s105 sa39 STOICHIOMETRY ID COMPLEX
component stoichiometry: Terminator elements s107 sa42 STOICHIOMETRY ID COMPLEX
component stoichiometry: UCE s102 sa36 STOICHIOMETRY ID COMPLEX
component stoichiometry: gene s104 sa38 STOICHIOMETRY ID COMPLEX
component stoichiometry: TTF I s99 a89 STOICHIOMETRY ID COMPLEX
component stoichiometry: 28S s106 sa41 STOICHIOMETRY ID COMPLEX
component stoichiometry: RNA Polymerase I Complex s100 a91 STOICHIOMETRY ID COMPLEX
component stoichiometry: rRNA s101 a92 STOICHIOMETRY ID COMPLEX
component stoichiometry: Promoter s103 sa37 STOICHIOMETRY ID COMPLEX
component: UCE
component: TTF-I
component: 28S
component: Promoter
component: Terminator elements
component: 18S
component: gene
component: rRNA
component: RNA Polymerase I Complex
feature: COMPLEX BINDING FEATURE s98 a88 233
feature: COMPLEX BINDING FEATURE s98 a88 229
feature: COMPLEX BINDING FEATURE s98 a88 239
feature: COMPLEX BINDING FEATURE s98 a88 231
feature: COMPLEX BINDING FEATURE s98 a88 241
feature: COMPLEX BINDING FEATURE s98 a88 235
feature: COMPLEX BINDING FEATURE s98 a88 245
feature: COMPLEX BINDING FEATURE s98 a88 237
feature: COMPLEX BINDING FEATURE s98 a88 243

rRNA
type: RnaRegion
comment: SPECIES_TYPE=RNA

uniprot P20028 64
type: UnificationXref
id: P20028
db: uniprot

uniprot O52004 90
type: UnificationXref
id: O52004
db: uniprot

uniprot Q7RVB4 159
type: UnificationXref
id: Q7RVB4
db: uniprot

ncbitaxon 9606 20
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot Q9H9Y6 79
type: UnificationXref
id: Q9H9Y6
db: uniprot

uniprot P26355 143
type: UnificationXref
id: P26355
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 62

Uncharacterized protein
type: ProteinReference
xref: PTHR46318:SF4
xref: uniprot F1MCZ7 116
organism: Bos taurus

TATA-box-binding protein 3
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q8TTZ7 104
organism: Methanosarcina acetivorans

uniprot D4A898 84
type: UnificationXref
id: D4A898
db: uniprot

Thermococcus kodakaraensis
type: BioSource
xref: ncbitaxon 69014 98

TATA box-binding protein-like protein 2
type: ProteinReference
xref: PTHR10126:SF37
xref: uniprot A6H907 127
organism: Pan troglodytes

uniprot P17480 118
type: UnificationXref
id: P17480
db: uniprot

uniprot P25976 119
type: UnificationXref
id: P25976
db: uniprot

uniprot Q28CR4 77
type: UnificationXref
id: Q28CR4
db: uniprot

TATA box-binding protein-like protein 2
type: ProteinReference
xref: PTHR10126:SF37
xref: uniprot Q6SJ95 155
organism: Mus musculus

TATA box-binding protein-like protein 2
type: ProteinReference
xref: PTHR10126:SF37
xref: uniprot Q6SJ96 156
organism: Homo sapiens

eco ECO:0000250 12
type: UnificationXref
id: ECO:0000250
db: eco

Transcription termination factor 1
type: ProteinReference
xref: uniprot Q15361 113
xref: PTHR46760:SF1
organism: Homo sapiens

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot P17871 140
organism: Schizosaccharomyces pombe

TTF-I
type: ProteinReference
xref: P00654
standard name: Trascription termination factor RNA polymerase I
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=General transcription by RNA polymerase I.PROTEIN.GENERIC.TTF-I
comment: ENTITY_REFERENCE_NOTES=Long Name: TTF-1 Synonym: TRANSCRIPTION TERMINATION FACTOR RNA POLYMERASE I Accession: P00654
member entity reference: Transcription termination factor 1
member entity reference: TTF1 isoform 2

18S
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s83 sa25 204
comment: SPECIES_TYPE=GENE

uniprot Q6PDZ2 28
type: UnificationXref
id: Q6PDZ2
db: uniprot

18S
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s55 sa32 170
comment: SPECIES_TYPE=GENE

TATA box-binding protein-like protein 2
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q1JPY4 148
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GVV6 55
organism: Macaca mulatta

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 16

TATA box-binding protein-associated factor RNA polymerase I subunit C
type: ProteinReference
xref: uniprot Q6PDZ2 28
xref: PTHR15319:SF1
organism: Mus musculus

uniprot F4I366 51
type: UnificationXref
id: F4I366
db: uniprot

TATA box-binding protein-associated factor RNA polymerase I subunit B
type: ProteinReference
xref: uniprot P97358 41
organism: Mus musculus

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 23

TTF-I
type: Protein
entity reference: TTF-I
feature: COMPLEX PARTICIPANT BINDING FEATURE s111 a99 252
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 6238 129
type: UnificationXref
id: 6238
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r15 285
type: Stoichiometry
physical entity: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
stoichiometric coefficient: 1.0

RRN3 RNA polymerase I transcription factor homolog
type: ProteinReference
xref: uniprot H2QAM4 56
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r15 287
type: Stoichiometry
physical entity: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r15 286
type: Stoichiometry
physical entity: RNA Polymerase I Complex
stoichiometric coefficient: 1.0

TATA-box-binding protein
type: ProteinReference
xref: uniprot Q52366 97
xref: PTHR10126:SF42
organism: Thermococcus kodakaraensis

ncbitaxon 44689 144
type: UnificationXref
id: 44689
db: ncbitaxon

TATA-box-binding protein F
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q9HHE9 108
organism: Halobacterium salinarum

DNA-directed RNA polymerase subunit beta
type: ProteinReference
xref: uniprot A6QLS0 46
xref: PTHR20856:SF5
organism: Bos taurus

TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 1
type: ProteinReference
xref: PTHR15319:SF1
xref: uniprot F6UPU0 10
organism: Macaca mulatta

RCG43696, isoform CRA_b
type: ProteinReference
xref: uniprot D3ZY89 4
xref: PTHR46469:SF1
organism: Rattus norvegicus

Probable DNA-directed RNA polymerases I and III subunit RPAC2
type: ProteinReference
xref: uniprot P34476 68
organism: Caenorhabditis elegans

DNA-directed RNA polymerase I subunit RPA2
type: ProteinReference
xref: PTHR20856:SF5
xref: uniprot P20028 64
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_TTF_I-RIGHT__UBF1-_Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_SL1_complex-_re13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 304
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 305
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 303
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 302
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 301
left: TTF-I
left: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
interaction type: STATE_TRANSITION
right: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
right: UBF1
right: SL1 complex

uniprot P36070 69
type: UnificationXref
id: P36070
db: uniprot

DNA-directed RNA polymerases I and III subunit RPAC2
type: ProteinReference
xref: uniprot P0DPB6 63
xref: PTHR13946:SF28
organism: Homo sapiens

PTHR15240:SF3
type: RelationshipXref
id: PTHR15240:SF3
db: PANTHER Family
relationship type: By Homology

uniprot F1PQA5 133
type: UnificationXref
id: F1PQA5
db: uniprot

RNA Polymerase I Complex
type: Protein
entity reference: RNA Polymerase I Complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s79 a84 196
comment: SPECIES_TYPE=PROTEIN

RNA polymerase I-specific transcription initiation factor RRN3
type: ProteinReference
xref: uniprot P36070 69
organism: Saccharomyces cerevisiae

Promoter
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s92 sa9 220
comment: SPECIES_TYPE=GENE

uniprot Q1JPY4 148
type: UnificationXref
id: Q1JPY4
db: uniprot

uniprot Q8TI26 102
type: UnificationXref
id: Q8TI26
db: uniprot

gene s104 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: gene
stoichiometric coefficient: 2.0

uniprot H2QWI2 57
type: UnificationXref
id: H2QWI2
db: uniprot

28S
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s74 sa20 188
comment: SPECIES_TYPE=GENE

UCE s102 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: UCE
stoichiometric coefficient: 1.0

28S
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s84 sa27 206
comment: SPECIES_TYPE=GENE

uniprot Q9S7R9 36
type: UnificationXref
id: Q9S7R9
db: uniprot

SL1 complex s69 a73 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SL1 complex
stoichiometric coefficient: 2.0

ncbitaxon 367110 62
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot F1RDV9 50
type: UnificationXref
id: F1RDV9
db: uniprot

uniprot Q27493 76
type: UnificationXref
id: Q27493
db: uniprot

uniprot O13270 138
type: UnificationXref
id: O13270
db: uniprot

Transcription termination factor 1
type: ProteinReference
xref: uniprot Q62187 114
xref: PTHR46760:SF1
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YKC3 136
organism: Macaca mulatta

Promoter s103 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Promoter
stoichiometric coefficient: 1.0

uniprot H9H459 59
type: UnificationXref
id: H9H459
db: uniprot

uniprot P17871 140
type: UnificationXref
id: P17871
db: uniprot

uniprot Q32LB1 95
type: UnificationXref
id: Q32LB1
db: uniprot

uniprot E2RI73 49
type: UnificationXref
id: E2RI73
db: uniprot

Bromodomain transcription factor
type: ProteinReference
xref: uniprot Q9LF25 34
xref: PTHR46338:SF10
organism: Arabidopsis thaliana

Caveolae-associated protein 1
type: ProteinReference
xref: uniprot Q6NZI2 126
xref: PTHR15240:SF3
organism: Homo sapiens

rRNA
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s112 a100 254
comment: SPECIES_TYPE=RNA

ncbitaxon 7165 158
type: UnificationXref
id: 7165
db: ncbitaxon

Promoter
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s114 sa44 258
comment: SPECIES_TYPE=GENE

uniprot Q9EQH4 33
type: UnificationXref
id: Q9EQH4
db: uniprot

Terminator elements s75 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Terminator elements
stoichiometric coefficient: 1.0

18S s151 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 18S
stoichiometric coefficient: 1.0

uniprot Q15573 44
type: UnificationXref
id: Q15573
db: uniprot

uniprot Q7SXL3 160
type: UnificationXref
id: Q7SXL3
db: uniprot

TATA box-binding protein-associated factor RNA polymerase I subunit B
type: ProteinReference
xref: uniprot Q53T94 42
organism: Homo sapiens

TBP-related factor
type: ProteinReference
xref: PTHR10126:SF41
xref: uniprot Q27896 149
organism: Drosophila melanogaster

gene
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s82 sa24 202
comment: SPECIES_TYPE=GENE

uniprot F1MCZ7 116
type: UnificationXref
id: F1MCZ7
db: uniprot

DNA-directed RNA polymerase subunit beta
type: ProteinReference
xref: PTHR20856:SF5
xref: uniprot Q27493 76
organism: Caenorhabditis elegans

TAF1C isoform 5
type: ProteinReference
xref: uniprot H2QBM1 15
xref: PTHR15319:SF1
organism: Pan troglodytes

Bos taurus
type: BioSource
xref: ncbitaxon 9913 3

UNKNOWN_TRANSITION
type: InteractionVocabulary

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 11

TAF-IC
type: Protein
entity reference: TAF-IC
comment: SPECIES_TYPE=PROTEIN

PSMC3 interacting protein
type: ProteinReference
xref: uniprot H2QD27 89
xref: PTHR15938:SF0
organism: Pan troglodytes

uniprot Q9HN56 109
type: UnificationXref
id: Q9HN56
db: uniprot

POLR1D isoform 6
type: ProteinReference
xref: PTHR13946:SF28
xref: uniprot H2RA83 58
organism: Pan troglodytes

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 87

28S s117 sa48 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 28S
stoichiometric coefficient: 1.0

gene s115 sa45 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: gene
stoichiometric coefficient: 2.0

Uncharacterized protein
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot F6S0M5 8
organism: Monodelphis domestica

uniprot Q1RMG8 75
type: UnificationXref
id: Q1RMG8
db: uniprot

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q8ZVR0 106
organism: Pyrobaculum aerophilum

uniprot H2RD22 137
type: UnificationXref
id: H2RD22
db: uniprot

DNA-directed RNA polymerase I subunit 2
type: ProteinReference
xref: uniprot F4I366 51
xref: PTHR20856:SF5
organism: Arabidopsis thaliana

uniprot B2D6P4 83
type: UnificationXref
id: B2D6P4
db: uniprot

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 103

PTRF
type: ProteinReference
xref: P00656
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: PTRF Synonym: RNA polymerase I and transcript release factor,TTF-I interacting peptide 12,polymerase I and transcript release factor Accession: P00656
comment: ENTITY_REFERENCE_ID_DESC=General transcription by RNA polymerase I.PROTEIN.GENERIC.PTRF
member entity reference: Caveolae-associated protein 1
member entity reference: Caveolae associated protein 1
member entity reference: CAVIN1 isoform 1
member entity reference: Uncharacterized protein

ncbitaxon 243232 100
type: UnificationXref
id: 243232
db: ncbitaxon

SL1 complex
type: Protein
entity reference: SL1 complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s78 a75 192
comment: SPECIES_TYPE=PROTEIN

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot P13393 139
organism: Saccharomyces cerevisiae

uniprot C4M7H7 130
type: UnificationXref
id: C4M7H7
db: uniprot

uniprot E1BNE7 121
type: UnificationXref
id: E1BNE7
db: uniprot

gene
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s72 sa17 184
comment: SPECIES_TYPE=GENE

Spermatocyte arrest
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot Q9VP40 38
organism: Drosophila melanogaster

TATA-box-binding protein 2
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot C4M7H7 130
organism: Entamoeba histolytica

uniprot Q07DP5 94
type: UnificationXref
id: Q07DP5
db: uniprot

gene s72 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: gene
stoichiometric coefficient: 2.0

Terminator elements
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s118 sa49 266
comment: SPECIES_TYPE=GENE

DNA-directed RNA polymerases I and III subunit RPAC2
type: ProteinReference
xref: PTHR13946:SF28
xref: uniprot P97304 72
organism: Mus musculus

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 7

18S
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s73 sa18 186
comment: SPECIES_TYPE=GENE

STATE_TRANSITION_LEFT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_RNA_Polymerase_I__Complex-RIGHT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_r15
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 285
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 287
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 286
left: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
left: RNA Polymerase I Complex
interaction type: STATE_TRANSITION
right: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)

uniprot A0A1D5QTZ1 115
type: UnificationXref
id: A0A1D5QTZ1
db: uniprot

rRNA s112 a100 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: rRNA
stoichiometric coefficient: 1.0

PTHR20856:SF5
type: RelationshipXref
id: PTHR20856:SF5
db: PANTHER Family
relationship type: By Homology

ncbitaxon 5664 152
type: UnificationXref
id: 5664
db: ncbitaxon

AGAP010958-PA
type: ProteinReference
xref: uniprot Q7PFI3 157
xref: PTHR10126:SF42
organism: Anopheles gambiae

ncbitaxon 9258 87
type: UnificationXref
id: 9258
db: ncbitaxon

TATA box-binding protein-like protein 1
type: ProteinReference
xref: uniprot Q9YGV8 111
xref: PTHR10126:SF55
organism: Gallus gallus

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 25

PARTICIPANT STOICHIOMETRY r8 300
type: Stoichiometry
physical entity: SL1 complex
stoichiometric coefficient: 1.0

UBF1 s66 a60 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: UBF1
stoichiometric coefficient: 2.0

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 107

18S
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s151 sa4 274
comment: SPECIES_TYPE=GENE

uniprot Q66HB1 154
type: UnificationXref
id: Q66HB1
db: uniprot

uniprot Q9P7X8 81
type: UnificationXref
id: Q9P7X8
db: uniprot

TATA-box-binding protein 1
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q8TI26 102
organism: Methanosarcina acetivorans

uniprot O54724 124
type: UnificationXref
id: O54724
db: uniprot

TATA box-binding protein-like protein 1
type: ProteinReference
xref: uniprot Q32LB1 95
xref: PTHR10126:SF55
organism: Bos taurus

uniprot Q15572 19
type: UnificationXref
id: Q15572
db: uniprot

TATA-box-binding protein
type: ProteinReference
xref: uniprot P20227 142
xref: PTHR10126:SF42
organism: Drosophila melanogaster

TATA-box-binding protein
type: ProteinReference
xref: uniprot P20226 141
xref: PTHR10126:SF20
organism: Homo sapiens

PTHR46318:SF4
type: RelationshipXref
id: PTHR46318:SF4
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot Q53T94 42
type: UnificationXref
id: Q53T94
db: uniprot

uniprot H2RE35 122
type: UnificationXref
id: H2RE35
db: uniprot

uniprot F7GVV6 55
type: UnificationXref
id: F7GVV6
db: uniprot

TATA-box-binding protein C
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot O52004 90
organism: Halobacterium salinarum

PTHR12056:SF2
type: RelationshipXref
id: PTHR12056:SF2
db: PANTHER Family
relationship type: By Homology

uniprot P70700 71
type: UnificationXref
id: P70700
db: uniprot

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot Q5ZMS1 24
organism: Gallus gallus

uniprot F6UVN1 86
type: UnificationXref
id: F6UVN1
db: uniprot

TTF1 isoform 2
type: ProteinReference
xref: uniprot H2QY30 112
xref: PTHR46760:SF1
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10126:SF20
xref: uniprot F6SEF6 134
organism: Macaca mulatta

TATA box-binding protein-like protein 2
type: ProteinReference
xref: uniprot Q28DH2 150
xref: PTHR10126:SF37
organism: Xenopus tropicalis

uniprot A8X861 128
type: UnificationXref
id: A8X861
db: uniprot

UNKNOWN_TRANSITION_LEFT__TAF_IB-RIGHT__SL1_complex-_r8
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 300
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 299
left: TAF-IB
interaction type: UNKNOWN_TRANSITION
right: SL1 complex

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q57930 99
organism: Methanocaldococcus jannaschii

uniprot E2QZE2 47
type: UnificationXref
id: E2QZE2
db: uniprot

UBF1
type: ProteinReference
xref: P00655
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=General transcription by RNA polymerase I.PROTEIN.GENERIC.UBF1
comment: ENTITY_REFERENCE_NOTES=Long Name: UBF1 Synonym: NOR-90,UBTF,UPSTREAM BINDING TRANSCRIPTION FACTOR Accession: P00655
member entity reference: Uncharacterized protein
member entity reference: Nucleolar transcription factor 1

18S s94 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 18S
stoichiometric coefficient: 1.0

RNA Polymerase I Complex
type: ProteinReference
xref: P00652
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: RNA Polymerase I Complex Synonym: DKFZP586M0122,FLJ21915,RPA1,RPO1-4 Accession: P00652
comment: ENTITY_REFERENCE_ID_DESC=General transcription by RNA polymerase I.PROTEIN.GENERIC.RNA Polymerase I _br_Complex
member entity reference: POLR2K isoform 1
member entity reference: DNA-directed RNA polymerase I subunit RPA2
member entity reference: DNA-directed RNA polymerase subunit beta
member entity reference: DNA-directed RNA polymerases I, II, and III subunit RPABC4
member entity reference: Uncharacterized protein
member entity reference: DNA-directed RNA polymerases I and III subunit RPAC2
member entity reference: Probable DNA-directed RNA polymerases I and III subunit RPAC2
member entity reference: RNA polymerase I-specific transcription initiation factor RRN3
member entity reference: POLR1D isoform 6
member entity reference: Probable DNA-directed RNA polymerase I subunit RPA2
member entity reference: Polymerase (RNA) II (DNA directed) polypeptide K
member entity reference: Polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
member entity reference: RRN3 RNA polymerase I transcription factor homolog
member entity reference: DNA-directed RNA polymerase I subunit 2
member entity reference: DNA-directed RNA polymerase I subunit RPA135
member entity reference: RNA polymerase I-specific transcription initiation factor rrn3

SL1 complex
type: Protein
entity reference: SL1 complex
comment: SPECIES_TYPE=PROTEIN

Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
type: Complex
component stoichiometry: UCE s52 sa29 STOICHIOMETRY ID COMPLEX
component stoichiometry: 28S s56 sa34 STOICHIOMETRY ID COMPLEX
component stoichiometry: UBF1 s66 a60 STOICHIOMETRY ID COMPLEX
component stoichiometry: 18S s55 sa32 STOICHIOMETRY ID COMPLEX
component stoichiometry: Terminator elements s57 sa35 STOICHIOMETRY ID COMPLEX
component stoichiometry: Promoter s53 sa30 STOICHIOMETRY ID COMPLEX
component stoichiometry: gene s67 sa31 STOICHIOMETRY ID COMPLEX
component: Promoter
component: 28S
component: gene
component: 18S
component: UCE
component: UBF1
component: Terminator elements
feature: COMPLEX BINDING FEATURE s65 a58 173
feature: COMPLEX BINDING FEATURE s65 a58 161
feature: COMPLEX BINDING FEATURE s65 a58 169
feature: COMPLEX BINDING FEATURE s65 a58 163
feature: COMPLEX BINDING FEATURE s65 a58 167
feature: COMPLEX BINDING FEATURE s65 a58 165
feature: COMPLEX BINDING FEATURE s65 a58 171

PARTICIPANT STOICHIOMETRY re12 311
type: Stoichiometry
physical entity: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
stoichiometric coefficient: 1.0

TAF-IB
type: Protein
entity reference: TAF-IB
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re12 310
type: Stoichiometry
physical entity: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
stoichiometric coefficient: 1.0

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: uniprot Q6P0T2 26
xref: PTHR46469:SF1
organism: Danio rerio

uniprot Q52366 97
type: UnificationXref
id: Q52366
db: uniprot

UNKNOWN_TRANSITION_LEFT__TAF_IA-RIGHT__SL1_complex-_r7
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 306
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 307
left: TAF-IA
interaction type: UNKNOWN_TRANSITION
right: SL1 complex

Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
type: Complex
component stoichiometry: UCE s70 sa15 STOICHIOMETRY ID COMPLEX
component stoichiometry: Promoter s71 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: UBF1 s76 a71 STOICHIOMETRY ID COMPLEX
component stoichiometry: gene s72 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: Terminator elements s75 sa21 STOICHIOMETRY ID COMPLEX
component stoichiometry: 18S s73 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: SL1 complex s69 a73 STOICHIOMETRY ID COMPLEX
component stoichiometry: 28S s74 sa20 STOICHIOMETRY ID COMPLEX
component: 18S
component: SL1 complex
component: gene
component: Promoter
component: UCE
component: 28S
component: Terminator elements
component: UBF1
feature: COMPLEX BINDING FEATURE s68 a56 185
feature: COMPLEX BINDING FEATURE s68 a56 181
feature: COMPLEX BINDING FEATURE s68 a56 177
feature: COMPLEX BINDING FEATURE s68 a56 183
feature: COMPLEX BINDING FEATURE s68 a56 179
feature: COMPLEX BINDING FEATURE s68 a56 187
feature: COMPLEX BINDING FEATURE s68 a56 175
feature: COMPLEX BINDING FEATURE s68 a56 189

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 129

uniprot P28000 67
type: UnificationXref
id: P28000
db: uniprot

gene
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s104 sa38 240
comment: SPECIES_TYPE=GENE

At3g02160
type: ProteinReference
xref: uniprot Q9S7R9 36
xref: PTHR46338:SF7
organism: Arabidopsis thaliana

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 31

PTRF
type: Protein
entity reference: PTRF
comment: SPECIES_TYPE=PROTEIN

uniprot Q9P2W1 110
type: UnificationXref
id: Q9P2W1
db: uniprot

PARTICIPANT STOICHIOMETRY r6 308
type: Stoichiometry
physical entity: TBP
stoichiometric coefficient: 1.0

28S s74 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 28S
stoichiometric coefficient: 1.0

uniprot F6ZV36 52
type: UnificationXref
id: F6ZV36
db: uniprot

PARTICIPANT STOICHIOMETRY r6 309
type: Stoichiometry
physical entity: SL1 complex
stoichiometric coefficient: 1.0

uniprot O74633 61
type: UnificationXref
id: O74633
db: uniprot

uniprot F7G0B2 14
type: UnificationXref
id: F7G0B2
db: uniprot

DNA-directed RNA polymerase I subunit RPA2
type: ProteinReference
xref: PTHR20856:SF5
xref: uniprot P70700 71
organism: Mus musculus

uniprot H2QY30 112
type: UnificationXref
id: H2QY30
db: uniprot

uniprot F6YKC3 136
type: UnificationXref
id: F6YKC3
db: uniprot

ncbitaxon 10116 5
type: UnificationXref
id: 10116
db: ncbitaxon

TATA box-binding protein-associated factor RNA polymerase I subunit C
type: ProteinReference
xref: PTHR15319:SF1
xref: uniprot Q15572 19
organism: Homo sapiens

uniprot P13393 139
type: UnificationXref
id: P13393
db: uniprot

TATA box-binding protein-associated factor RNA polymerase I subunit A
type: ProteinReference
xref: PTHR32122:SF1
xref: uniprot Q15573 44
organism: Homo sapiens

DNA-directed RNA polymerases I, II, and III subunit RPABC4
type: ProteinReference
xref: PTHR12056:SF2
xref: uniprot P53803 70
organism: Homo sapiens

uniprot P20226 141
type: UnificationXref
id: P20226
db: uniprot

18S
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s116 sa46 262
comment: SPECIES_TYPE=GENE

Terminator elements
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s75 sa21 190
comment: SPECIES_TYPE=GENE

uniprot Q5ZMS1 24
type: UnificationXref
id: Q5ZMS1
db: uniprot

UCE s70 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: UCE
stoichiometric coefficient: 1.0

uniprot F7A8N8 53
type: UnificationXref
id: F7A8N8
db: uniprot

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot Q9VWY6 40
organism: Drosophila melanogaster

uniprot P34476 68
type: UnificationXref
id: P34476
db: uniprot

TATA box-binding protein-like protein 1
type: ProteinReference
xref: uniprot P62340 92
xref: PTHR10126:SF55
organism: Mus musculus

18S
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s94 sa11 224
comment: SPECIES_TYPE=GENE

UNKNOWN_TRANSITION
type: RelationshipTypeVocabulary

ncbitaxon 5759 131
type: UnificationXref
id: 5759
db: ncbitaxon

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 91

uniprot A0A2I3S2L7 45
type: UnificationXref
id: A0A2I3S2L7
db: uniprot

uniprot P22138 65
type: UnificationXref
id: P22138
db: uniprot

Nucleolar transcription factor 1
type: ProteinReference
xref: PTHR46318:SF4
xref: uniprot P17480 118
organism: Homo sapiens

uniprot F6SEF6 134
type: UnificationXref
id: F6SEF6
db: uniprot

Terminator elements s57 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Terminator elements
stoichiometric coefficient: 1.0

RNA polymerase I-specific transcription initiation factor rrn3
type: ProteinReference
xref: uniprot Q10110 74
organism: Schizosaccharomyces pombe

TBP-Like Factor
type: ProteinReference
xref: uniprot B2D6P4 83
xref: PTHR10126:SF55
organism: Caenorhabditis elegans

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 158

uniprot E2RN76 6
type: UnificationXref
id: E2RN76
db: uniprot

Promoter s92 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Promoter
stoichiometric coefficient: 1.0

PTHR46469:SF1
type: RelationshipXref
id: PTHR46469:SF1
db: PANTHER Family
relationship type: By Homology

SL1 complex
type: Protein
entity reference: SL1 complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s88 a81 212
comment: SPECIES_TYPE=PROTEIN

uniprot P97358 41
type: UnificationXref
id: P97358
db: uniprot

uniprot Q6P0T2 26
type: UnificationXref
id: Q6P0T2
db: uniprot

rRNA s90 a87 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: rRNA
stoichiometric coefficient: 1.0

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot P26355 143
organism: Dictyostelium discoideum

uniprot Q7Z7C8 32
type: UnificationXref
id: Q7Z7C8
db: uniprot

TATA-box-binding protein 1
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot P52653 147
organism: Entamoeba histolytica

gene s67 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: gene
stoichiometric coefficient: 2.0

Terminator elements s107 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Terminator elements
stoichiometric coefficient: 1.0

28S
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s152 sa6 276
comment: SPECIES_TYPE=GENE

ncbitaxon 9598 16
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot Q6SJ95 155
type: UnificationXref
id: Q6SJ95
db: uniprot

uniprot Q6DIY4 101
type: UnificationXref
id: Q6DIY4
db: uniprot

TAF-IA
type: Protein
entity reference: TAF-IA
comment: SPECIES_TYPE=PROTEIN

TAF-IB
type: ProteinReference
xref: P00650
standard name: TPB assoaciate factor 1B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=General transcription by RNA polymerase I.PROTEIN.GENERIC.TAF-IB
comment: ENTITY_REFERENCE_NOTES=Long Name: TAF-IB Synonym: MGC:9349,RAF1B,RAFI63,SL1,TAFI63,TBP-associated factor 1B Accession: P00650
member entity reference: Transcription initiation factor TFIID subunit 8
member entity reference: TATA-box binding protein associated factor 8
member entity reference: RCG43696, isoform CRA_b
member entity reference: Spermatocyte arrest
member entity reference: TATA box-binding protein-associated factor RNA polymerase I subunit B
member entity reference: At3g02160
member entity reference: TAF (TBP-associated transcription factor) family
member entity reference: Uncharacterized protein
member entity reference: Bromodomain transcription factor

Uncharacterized protein
type: ProteinReference
xref: PTHR13946:SF28
xref: uniprot H9H459 59
organism: Macaca mulatta

TATA box-binding protein-like protein 1
type: ProteinReference
xref: uniprot Q5U385 153
xref: PTHR10126:SF55
organism: Danio rerio

uniprot D3ZY89 4
type: UnificationXref
id: D3ZY89
db: uniprot

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: PTHR46338:SF1
xref: uniprot O94706 17
organism: Schizosaccharomyces pombe

DNA-directed RNA polymerase subunit beta
type: ProteinReference
xref: PTHR20856:SF5
xref: uniprot F7A8N8 53
organism: Macaca mulatta

uniprot H2QD27 89
type: UnificationXref
id: H2QD27
db: uniprot

TATA-binding protein
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q7RVB4 159
organism: Neurospora crassa

uniprot Q09177 73
type: UnificationXref
id: Q09177
db: uniprot

CAVIN1 isoform 1
type: ProteinReference
xref: PTHR15240:SF3
xref: uniprot H2RE35 122
organism: Pan troglodytes

P00652
type: UnificationXref
id: P00652
db: PANTHER Pathway Component

P00651
type: UnificationXref
id: P00651
db: PANTHER Pathway Component

uniprot Q8TU94 105
type: UnificationXref
id: Q8TU94
db: uniprot

rRNA
type: RnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s90 a87 216
comment: SPECIES_TYPE=RNA

P00650
type: UnificationXref
id: P00650
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_PTRF-RIGHT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_re14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 297
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 296
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 298
left: PTRF
left: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
interaction type: STATE_TRANSITION
right: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 131

RNA Polymerase I Complex s109 a95 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RNA Polymerase I Complex
stoichiometric coefficient: 1.0

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 12

uniprot Q9YGV8 111
type: UnificationXref
id: Q9YGV8
db: uniprot

TBP
type: Protein
entity reference: TBP
comment: SPECIES_TYPE=PROTEIN

UCE s148 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: UCE
stoichiometric coefficient: 1.0

TATA-box binding protein
type: ProteinReference
xref: uniprot F1PQA5 133
xref: PTHR10126:SF20
organism: Canis lupus familiaris

P00649
type: UnificationXref
id: P00649
db: PANTHER Pathway Component

TATA-box binding protein
type: ProteinReference
xref: uniprot H2RD22 137
xref: PTHR10126:SF20
organism: Pan troglodytes

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot P32085 146
organism: Caenorhabditis elegans

28S
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s56 sa34 172
comment: SPECIES_TYPE=GENE

Promoter
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s149 sa2 270
comment: SPECIES_TYPE=GENE

DNA-directed RNA polymerase subunit beta
type: ProteinReference
xref: uniprot A0A2I3S2L7 45
xref: PTHR20856:SF5
organism: Pan troglodytes

ncbitaxon 284812 18
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot Q9SYZ9 37
type: UnificationXref
id: Q9SYZ9
db: uniprot

SL1 complex
type: Protein
entity reference: SL1 complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s69 a73 178
comment: SPECIES_TYPE=PROTEIN

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 9

UCE
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s113 sa43 256
comment: SPECIES_TYPE=GENE

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF20
xref: uniprot O13270 138
organism: Gallus gallus

TBP
type: ProteinReference
xref: P00657
standard name: Tata binding protein
comment: ENTITY_REFERENCE_ID_DESC=General transcription by RNA polymerase I.PROTEIN.GENERIC.TBP
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: TBP Synonym: GTF2D,GTF2D1,SCA17,TATA-binding protein,TFIID,spinocerebellar ataxia 17 Accession: P00657
member entity reference: AGAP010958-PA
member entity reference: Uncharacterized protein
member entity reference: TATA-box-binding protein
member entity reference: TATA box-binding protein-like protein 1
member entity reference: TATA box binding protein, isoform CRA_a
member entity reference: TATA-box binding protein
member entity reference: TATA box-binding protein-like protein 2
member entity reference: TATA-box-binding protein 2
member entity reference: TBP-Like Factor
member entity reference: Protein CBR-TBP-1
member entity reference: TATA-box-binding protein 1
member entity reference: PSMC3 interacting protein
member entity reference: TATA-box binding protein like 1
member entity reference: TATA-binding protein
member entity reference: TATA-box-binding protein 3
member entity reference: Transcription initiation factor-like protein (TFIID-like protein)
member entity reference: TBP-related factor
member entity reference: TATA-box-binding protein-like 1

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot Q28J24 22
organism: Xenopus tropicalis

Terminator elements
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s85 sa28 208
comment: SPECIES_TYPE=GENE

uniprot Q9VWY6 40
type: UnificationXref
id: Q9VWY6
db: uniprot

uniprot Q15361 113
type: UnificationXref
id: Q15361
db: uniprot

P00657
type: UnificationXref
id: P00657
db: PANTHER Pathway Component

ncbitaxon 69014 98
type: UnificationXref
id: 69014
db: ncbitaxon

uniprot H2QAM4 56
type: UnificationXref
id: H2QAM4
db: uniprot

TATA-box-binding protein-like 1
type: ProteinReference
xref: uniprot D4A898 84
xref: PTHR10126:SF55
organism: Rattus norvegicus

P00653
type: UnificationXref
id: P00653
db: PANTHER Pathway Component

P00654
type: UnificationXref
id: P00654
db: PANTHER Pathway Component

P00655
type: UnificationXref
id: P00655
db: PANTHER Pathway Component

Protein CBR-TBP-1
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot A8X861 128
organism: Caenorhabditis briggsae

P00656
type: UnificationXref
id: P00656
db: PANTHER Pathway Component

uniprot E2RCC0 132
type: UnificationXref
id: E2RCC0
db: uniprot

uniprot Q9NYV6 80
type: UnificationXref
id: Q9NYV6
db: uniprot

DNA-directed RNA polymerases I, II, and III subunit RPABC4
type: ProteinReference
xref: PTHR12056:SF2
xref: uniprot F7FMW4 54
organism: Macaca mulatta

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 18

uniprot Q48325 96
type: UnificationXref
id: Q48325
db: uniprot

gene
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s115 sa45 260
comment: SPECIES_TYPE=GENE

Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
type: Complex
component stoichiometry: RNA Polymerase I Complex s79 a84 STOICHIOMETRY ID COMPLEX
component stoichiometry: 18S s83 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: Terminator elements s85 sa28 STOICHIOMETRY ID COMPLEX
component stoichiometry: gene s82 sa24 STOICHIOMETRY ID COMPLEX
component stoichiometry: SL1 complex s78 a75 STOICHIOMETRY ID COMPLEX
component stoichiometry: UBF1 s86 a77 STOICHIOMETRY ID COMPLEX
component stoichiometry: UCE s80 sa22 STOICHIOMETRY ID COMPLEX
component stoichiometry: Promoter s81 sa23 STOICHIOMETRY ID COMPLEX
component stoichiometry: 28S s84 sa27 STOICHIOMETRY ID COMPLEX
component: 18S
component: RNA Polymerase I Complex
component: Promoter
component: 28S
component: gene
component: SL1 complex
component: UCE
component: Terminator elements
component: UBF1
feature: COMPLEX BINDING FEATURE s77 a57 195
feature: COMPLEX BINDING FEATURE s77 a57 205
feature: COMPLEX BINDING FEATURE s77 a57 207
feature: COMPLEX BINDING FEATURE s77 a57 203
feature: COMPLEX BINDING FEATURE s77 a57 197
feature: COMPLEX BINDING FEATURE s77 a57 191
feature: COMPLEX BINDING FEATURE s77 a57 201
feature: COMPLEX BINDING FEATURE s77 a57 199
feature: COMPLEX BINDING FEATURE s77 a57 193

uniprot Q28DH2 150
type: UnificationXref
id: Q28DH2
db: uniprot

uniprot F6UPU0 10
type: UnificationXref
id: F6UPU0
db: uniprot

Promoter
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s53 sa30 166
comment: SPECIES_TYPE=GENE

TATA box binding protein-related factor 2, isoform E
type: ProteinReference
xref: uniprot Q07DP5 94
xref: PTHR10126:SF55
organism: Drosophila melanogaster

UCE
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s80 sa22 198
comment: SPECIES_TYPE=GENE

gene
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s150 sa3 272
comment: SPECIES_TYPE=GENE

uniprot P53803 70
type: UnificationXref
id: P53803
db: uniprot

ncbitaxon 6239 31
type: UnificationXref
id: 6239
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r8 299
type: Stoichiometry
physical entity: TAF-IB
stoichiometric coefficient: 1.0

Promoter
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s103 sa37 238
comment: SPECIES_TYPE=GENE

STATE_TRANSITION_LEFT__UBF1-_Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-RIGHT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_re16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 291
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 292
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 293
left: UBF1
left: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
interaction type: STATE_TRANSITION
right: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)

DNA-directed RNA polymerases I, II, and III subunit RPABC4
type: ProteinReference
xref: PTHR12056:SF2
xref: uniprot Q3ZBC0 78
organism: Bos taurus

uniprot Q9VP40 38
type: UnificationXref
id: Q9VP40
db: uniprot

uniprot E1BEL5 85
type: UnificationXref
id: E1BEL5
db: uniprot

Caveolae associated protein 1
type: ProteinReference
xref: uniprot J9P923 123
xref: PTHR15240:SF3
organism: Canis lupus familiaris

Promoter s53 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Promoter
stoichiometric coefficient: 1.0

SL1 complex s88 a81 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SL1 complex
stoichiometric coefficient: 2.0

UCE
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s91 sa8 218
comment: SPECIES_TYPE=GENE

ncbitaxon 9031 25
type: UnificationXref
id: 9031
db: ncbitaxon

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 20

RNA Polymerase I Complex
type: Protein
entity reference: RNA Polymerase I Complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s100 a91 232
comment: SPECIES_TYPE=PROTEIN

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 100

28S
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s117 sa48 264
comment: SPECIES_TYPE=GENE

UBF1 s76 a71 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: UBF1
stoichiometric coefficient: 2.0

ncbitaxon 7955 27
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot Q7YTH5 30
type: UnificationXref
id: Q7YTH5
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 35

UCE s52 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: UCE
stoichiometric coefficient: 1.0

ncbitaxon 9615 7
type: UnificationXref
id: 9615
db: ncbitaxon

UCE
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s148 sa1 268
comment: SPECIES_TYPE=GENE

PARTICIPANT STOICHIOMETRY re13 301
type: Stoichiometry
physical entity: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
stoichiometric coefficient: 1.0

uniprot P97304 72
type: UnificationXref
id: P97304
db: uniprot

PARTICIPANT STOICHIOMETRY re13 305
type: Stoichiometry
physical entity: SL1 complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re13 304
type: Stoichiometry
physical entity: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
stoichiometric coefficient: 1.0

ncbitaxon 7227 39
type: UnificationXref
id: 7227
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re13 303
type: Stoichiometry
physical entity: UBF1
stoichiometric coefficient: 1.0

PANTHER Pathway P00022 1
type: UnificationXref
id: P00022
db: PANTHER Pathway

PARTICIPANT STOICHIOMETRY re13 302
type: Stoichiometry
physical entity: TTF-I
stoichiometric coefficient: 1.0

uniprot Q27896 149
type: UnificationXref
id: Q27896
db: uniprot

18S s116 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 18S
stoichiometric coefficient: 1.0

UCE s113 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: UCE
stoichiometric coefficient: 1.0

uniprot H2QBM1 15
type: UnificationXref
id: H2QBM1
db: uniprot

TATA-box-binding protein E
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q9HN56 109
organism: Halobacterium salinarum

TATA-box-binding protein B
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q48325 96
organism: Halobacterium salinarum

Danio rerio
type: BioSource
xref: ncbitaxon 7955 27

uniprot O54888 60
type: UnificationXref
id: O54888
db: uniprot

Terminator elements s118 sa49 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Terminator elements
stoichiometric coefficient: 1.0

uniprot Q4QD71 151
type: UnificationXref
id: Q4QD71
db: uniprot

28S s84 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 28S
stoichiometric coefficient: 1.0

SL1 complex s78 a75 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SL1 complex
stoichiometric coefficient: 2.0

By Homology
type: RelationshipTypeVocabulary

uniprot O94706 17
type: UnificationXref
id: O94706
db: uniprot

PTHR10126:SF37
type: RelationshipXref
id: PTHR10126:SF37
db: PANTHER Family
relationship type: By Homology

Terminator elements
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s96 sa14 228
comment: SPECIES_TYPE=GENE

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DF94 117
organism: Monodelphis domestica

Terminator elements s153 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Terminator elements
stoichiometric coefficient: 1.0

uniprot Q9HHE9 108
type: UnificationXref
id: Q9HHE9
db: uniprot

uniprot P32085 146
type: UnificationXref
id: P32085
db: uniprot

Terminator elements
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s153 sa7 278
comment: SPECIES_TYPE=GENE

uniprot Q5U385 153
type: UnificationXref
id: Q5U385
db: uniprot

Polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
type: ProteinReference
xref: PTHR12056:SF2
xref: uniprot Q28CR4 77
organism: Xenopus tropicalis

TAF-IA
type: ProteinReference
xref: P00651
standard name: TPB assoaciate factor 1A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: TAF-1A Synonym: TATA box binding protein (TBP)-associated factor,TBP-associated factor 1A isoform 1,TBP-associated factor 1A isoform 2 Accession: P00651
comment: ENTITY_REFERENCE_ID_DESC=General transcription by RNA polymerase I.PROTEIN.GENERIC.TAF-IA
member entity reference: Transcription initiation factor TFIID subunit 8
member entity reference: TATA-box binding protein associated factor 8
member entity reference: RCG43696, isoform CRA_b
member entity reference: Spermatocyte arrest
member entity reference: At3g02160
member entity reference: TATA box-binding protein-associated factor RNA polymerase I subunit A
member entity reference: TAF (TBP-associated transcription factor) family
member entity reference: Uncharacterized protein
member entity reference: Bromodomain transcription factor
member entity reference: TAF1A isoform 2

uniprot P52653 147
type: UnificationXref
id: P52653
db: uniprot

TAF-IC
type: ProteinReference
xref: P00649
standard name: TPB assoaciate factor 1C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=General transcription by RNA polymerase I.PROTEIN.GENERIC.TAF-IC
comment: ENTITY_REFERENCE_NOTES=Long Name: TAF-1C Synonym: MGC:39976,SL1,TAFI110,TAFI95,TBP-associated factor 1C,transcription factor SL1 Accession: P00649
member entity reference: Transcription initiation factor TFIID subunit 8
member entity reference: TATA-box binding protein associated factor 8
member entity reference: RCG43696, isoform CRA_b
member entity reference: Spermatocyte arrest
member entity reference: At3g02160
member entity reference: TAF1C isoform 5
member entity reference: TATA box-binding protein-associated factor RNA polymerase I subunit C
member entity reference: TAF (TBP-associated transcription factor) family
member entity reference: Uncharacterized protein
member entity reference: Bromodomain transcription factor
member entity reference: TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 1

PTHR10126:SF42
type: RelationshipXref
id: PTHR10126:SF42
db: PANTHER Family
relationship type: By Homology

PTHR10126:SF41
type: RelationshipXref
id: PTHR10126:SF41
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QTZ1 115
organism: Macaca mulatta

Terminator elements
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s107 sa42 246
comment: SPECIES_TYPE=GENE

Promoter s81 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Promoter
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 290
type: Stoichiometry
physical entity: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
stoichiometric coefficient: 1.0

PTHR13946:SF28
type: RelationshipXref
id: PTHR13946:SF28
db: PANTHER Family
relationship type: By Homology

TATA-box binding protein like 1
type: ProteinReference
xref: PTHR10126:SF55
xref: uniprot F6UVN1 86
organism: Ornithorhynchus anatinus

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 144

18S s73 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 18S
stoichiometric coefficient: 1.0

uniprot F7DF94 117
type: UnificationXref
id: F7DF94
db: uniprot

18S s105 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 18S
stoichiometric coefficient: 1.0

eco ECO:0000316 21
type: UnificationXref
id: ECO:0000316
db: eco

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F0J5 88
xref: PTHR10126:SF55
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r14 289
type: Stoichiometry
physical entity: SL1 complex
stoichiometric coefficient: 1.0

POLR2K isoform 1
type: ProteinReference
xref: PTHR12056:SF2
xref: uniprot H2QWI2 57
organism: Pan troglodytes

ncbitaxon 13616 9
type: UnificationXref
id: 13616
db: ncbitaxon

ncbitaxon 10090 29
type: UnificationXref
id: 10090
db: ncbitaxon

SL1 complex
type: ProteinReference
xref: P00653
standard name: SL1
comment: ENTITY_REFERENCE_NOTES=Long Name: SL1 Synonym: Selectivity Factor 1 Accession: P00653
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=General transcription by RNA polymerase I.PROTEIN.GENERIC.SL1 complex
member entity reference: Transcription initiation factor TFIID subunit 8
member entity reference: Uncharacterized protein
member entity reference: TATA-box binding protein associated factor 8
member entity reference: TATA box-binding protein-like protein 1
member entity reference: Homologous-pairing protein 2 homolog
member entity reference: RCG43696, isoform CRA_b
member entity reference: Spermatocyte arrest
member entity reference: TATA-box-binding protein F
member entity reference: TATA box-binding protein-associated factor RNA polymerase I subunit A
member entity reference: TAF (TBP-associated transcription factor) family
member entity reference: TBP-Like Factor
member entity reference: Bromodomain transcription factor
member entity reference: TATA-box-binding protein 1
member entity reference: TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 1
member entity reference: TATA-box binding protein like 1
member entity reference: At3g02160
member entity reference: TAF1C isoform 5
member entity reference: TATA-box-binding protein 3
member entity reference: TATA box-binding protein-associated factor RNA polymerase I subunit C
member entity reference: TATA-box-binding protein C
member entity reference: TATA-box-binding protein
member entity reference: TATA-box-binding protein B
member entity reference: PSMC3 interacting protein
member entity reference: TATA-box-binding protein-like 1
member entity reference: TATA-box-binding protein E
member entity reference: TATA box binding protein-related factor 2, isoform E
member entity reference: TATA-box-binding protein 2
member entity reference: TAF1A isoform 2

PTRF
type: Protein
entity reference: PTRF
feature: COMPLEX PARTICIPANT BINDING FEATURE s110 a98 250
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r14 288
type: Stoichiometry
physical entity: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
stoichiometric coefficient: 1.0

Terminator elements s85 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Terminator elements
stoichiometric coefficient: 1.0

UBF1
type: Protein
entity reference: UBF1
feature: COMPLEX PARTICIPANT BINDING FEATURE s76 a71 176
comment: SPECIES_TYPE=PROTEIN

DNA-directed RNA polymerase I subunit RPA2
type: ProteinReference
xref: uniprot O54888 60
xref: PTHR20856:SF5
organism: Rattus norvegicus

ncbitaxon 188937 103
type: UnificationXref
id: 188937
db: ncbitaxon

uniprot Q62187 114
type: UnificationXref
id: Q62187
db: uniprot

RNA Polymerase I Complex
type: Protein
entity reference: RNA Polymerase I Complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s89 a85 214
comment: SPECIES_TYPE=PROTEIN

uniprot F6S0M5 8
type: UnificationXref
id: F6S0M5
db: uniprot

gene
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s67 sa31 168
comment: SPECIES_TYPE=GENE

uniprot P62380 93
type: UnificationXref
id: P62380
db: uniprot

PTHR15319:SF1
type: RelationshipXref
id: PTHR15319:SF1
db: PANTHER Family
relationship type: By Homology

PTHR10126:SF20
type: RelationshipXref
id: PTHR10126:SF20
db: PANTHER Family
relationship type: By Homology

STATE TRANSITION LEFT Complex UCE Promoter gene 18S gene 28S Terminator elements -RIGHT Complex UCE Promoter gene 18S gene 28S Terminator elements - TTF I- RNA Polymerase I Complex- rRNA- PTRF- r20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 284
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 280
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 283
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 281
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 279
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 282
left: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
display name: STATE_TRANSITION_LEFT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-RIGHT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_TTF_I-_RNA_Polymerase_I__Complex-_rRNA-_PTRF-_r20
interaction type: STATE_TRANSITION
right: PTRF
right: TTF-I
right: RNA Polymerase I Complex
right: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
right: rRNA

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 5

UBF1
type: Protein
entity reference: UBF1
feature: COMPLEX PARTICIPANT BINDING FEATURE s97 a79 210
comment: SPECIES_TYPE=PROTEIN

uniprot Q6SJ96 156
type: UnificationXref
id: Q6SJ96
db: uniprot

uniprot Q6NZI2 126
type: UnificationXref
id: Q6NZI2
db: uniprot

PARTICIPANT STOICHIOMETRY re14 296
type: Stoichiometry
physical entity: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
stoichiometric coefficient: 1.0

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot Q9EQH4 33
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r7 307
type: Stoichiometry
physical entity: SL1 complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re14 298
type: Stoichiometry
physical entity: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
stoichiometric coefficient: 1.0

ncbitaxon 64091 91
type: UnificationXref
id: 64091
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r7 306
type: Stoichiometry
physical entity: TAF-IA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re14 297
type: Stoichiometry
physical entity: PTRF
stoichiometric coefficient: 1.0

ncbitaxon 559292 66
type: UnificationXref
id: 559292
db: ncbitaxon

ncbitaxon 178306 107
type: UnificationXref
id: 178306
db: ncbitaxon

Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
type: Complex
component stoichiometry: RNA Polymerase I Complex s89 a85 STOICHIOMETRY ID COMPLEX
component stoichiometry: UBF1 s97 a79 STOICHIOMETRY ID COMPLEX
component stoichiometry: 18S s94 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: UCE s91 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: Terminator elements s96 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: SL1 complex s88 a81 STOICHIOMETRY ID COMPLEX
component stoichiometry: gene s93 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: Promoter s92 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: 28S s95 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: rRNA s90 a87 STOICHIOMETRY ID COMPLEX
component: UCE
component: UBF1
component: 28S
component: Terminator elements
component: rRNA
component: RNA Polymerase I Complex
component: gene
component: SL1 complex
component: 18S
component: Promoter
feature: COMPLEX BINDING FEATURE s87 a55 225
feature: COMPLEX BINDING FEATURE s87 a55 221
feature: COMPLEX BINDING FEATURE s87 a55 211
feature: COMPLEX BINDING FEATURE s87 a55 219
feature: COMPLEX BINDING FEATURE s87 a55 213
feature: COMPLEX BINDING FEATURE s87 a55 227
feature: COMPLEX BINDING FEATURE s87 a55 217
feature: COMPLEX BINDING FEATURE s87 a55 223
feature: COMPLEX BINDING FEATURE s87 a55 215
feature: COMPLEX BINDING FEATURE s87 a55 209

uniprot E2REX8 48
type: UnificationXref
id: E2REX8
db: uniprot

Caveolae-associated protein 1
type: ProteinReference
xref: PTHR15240:SF3
xref: uniprot P85125 125
organism: Rattus norvegicus

Terminator elements s96 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Terminator elements
stoichiometric coefficient: 1.0

UBF1
type: Protein
entity reference: UBF1
feature: COMPLEX PARTICIPANT BINDING FEATURE s86 a77 194
comment: SPECIES_TYPE=PROTEIN

DNA-directed RNA polymerase I subunit RPA2
type: ProteinReference
xref: uniprot Q9H9Y6 79
xref: PTHR20856:SF5
organism: Homo sapiens

DNA-directed RNA polymerases I and III subunit RPAC2
type: ProteinReference
xref: PTHR13946:SF28
xref: uniprot Q1RMG8 75
organism: Bos taurus

ncbitaxon 3702 35
type: UnificationXref
id: 3702
db: ncbitaxon

ncbitaxon 8364 23
type: UnificationXref
id: 8364
db: ncbitaxon

RNA polymerase I-specific transcription initiation factor RRN3
type: ProteinReference
xref: uniprot Q9NYV6 80
organism: Homo sapiens

RNA Polymerase I Complex s89 a85 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RNA Polymerase I Complex
stoichiometric coefficient: 1.0

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: uniprot Q9SYZ9 37
xref: PTHR46338:SF1
organism: Arabidopsis thaliana

UNKNOWN_TRANSITION_LEFT__TBP-RIGHT__SL1_complex-_r6
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 308
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 309
left: TBP
interaction type: UNKNOWN_TRANSITION
right: SL1 complex

UCE
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s102 sa36 236
comment: SPECIES_TYPE=GENE

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: uniprot Q7Z7C8 32
xref: PTHR46469:SF1
organism: Homo sapiens

uniprot Q57930 99
type: UnificationXref
id: Q57930
db: uniprot

Caveolae-associated protein 1
type: ProteinReference
xref: uniprot O54724 124
xref: PTHR15240:SF3
organism: Mus musculus

TATA-box-binding protein
type: ProteinReference
xref: uniprot Q7SXL3 160
xref: PTHR10126:SF42
organism: Danio rerio

UCE s80 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: UCE
stoichiometric coefficient: 1.0

DNA-directed RNA polymerases I and III subunit RPAC2
type: ProteinReference
xref: uniprot Q09177 73
organism: Schizosaccharomyces pombe

uniprot A6H907 127
type: UnificationXref
id: A6H907
db: uniprot

uniprot A6H914 82
type: UnificationXref
id: A6H914
db: uniprot

Terminator elements
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s57 sa35 174
comment: SPECIES_TYPE=GENE

28S
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s95 sa13 226
comment: SPECIES_TYPE=GENE

RNA Polymerase I Complex s100 a91 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RNA Polymerase I Complex
stoichiometric coefficient: 1.0

uniprot Q3ZBC0 78
type: UnificationXref
id: Q3ZBC0
db: uniprot

TATA box binding protein, isoform CRA_a
type: ProteinReference
xref: PTHR10126:SF20
xref: uniprot Q66HB1 154
organism: Rattus norvegicus

uniprot Q10110 74
type: UnificationXref
id: Q10110
db: uniprot

DNA-directed RNA polymerase I subunit RPA135
type: ProteinReference
xref: PTHR20856:SF5
xref: uniprot P22138 65
organism: Saccharomyces cerevisiae

PTHR46338:SF7
type: RelationshipXref
id: PTHR46338:SF7
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9544 11
type: UnificationXref
id: 9544
db: ncbitaxon

DNA-directed RNA polymerase subunit beta
type: ProteinReference
xref: PTHR20856:SF5
xref: uniprot E2REX8 48
organism: Canis lupus familiaris

Nucleolar transcription factor 1
type: ProteinReference
xref: PTHR46318:SF4
xref: uniprot P25977 120
organism: Rattus norvegicus

STATE_TRANSITION
type: InteractionVocabulary

PTRF s110 a98 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PTRF
stoichiometric coefficient: 1.0

Nucleolar transcription factor 1
type: ProteinReference
xref: PTHR46318:SF4
xref: uniprot P25976 119
organism: Mus musculus

uniprot F6VEJ6 135
type: UnificationXref
id: F6VEJ6
db: uniprot

PTHR46338:SF1
type: RelationshipXref
id: PTHR46338:SF1
db: PANTHER Family
relationship type: By Homology

28S s95 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 28S
stoichiometric coefficient: 1.0

PTHR15938:SF0
type: RelationshipXref
id: PTHR15938:SF0
db: PANTHER Family
relationship type: By Homology

uniprot P62340 92
type: UnificationXref
id: P62340
db: uniprot

TATA box-binding protein-like protein 1
type: ProteinReference
xref: uniprot P62380 93
xref: PTHR10126:SF55
organism: Homo sapiens

Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
type: Complex
component stoichiometry: UCE s148 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: 28S s152 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: 18S s151 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: gene s150 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: Promoter s149 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Terminator elements s153 sa7 STOICHIOMETRY ID COMPLEX
component: Terminator elements
component: 18S
component: UCE
component: 28S
component: Promoter
component: gene
feature: COMPLEX BINDING FEATURE s147 a54 271
feature: COMPLEX BINDING FEATURE s147 a54 275
feature: COMPLEX BINDING FEATURE s147 a54 273
feature: COMPLEX BINDING FEATURE s147 a54 277
feature: COMPLEX BINDING FEATURE s147 a54 269
feature: COMPLEX BINDING FEATURE s147 a54 267

rRNA s101 a92 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: rRNA
stoichiometric coefficient: 1.0

28S s152 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 28S
stoichiometric coefficient: 1.0

UBF1 s86 a77 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: UBF1
stoichiometric coefficient: 2.0

28S
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s106 sa41 244
comment: SPECIES_TYPE=GENE

Promoter
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s81 sa23 200
comment: SPECIES_TYPE=GENE

Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
type: Complex
component stoichiometry: TTF I s111 a99 STOICHIOMETRY ID COMPLEX
component stoichiometry: rRNA s112 a100 STOICHIOMETRY ID COMPLEX
component stoichiometry: PTRF s110 a98 STOICHIOMETRY ID COMPLEX
component stoichiometry: 28S s117 sa48 STOICHIOMETRY ID COMPLEX
component stoichiometry: Promoter s114 sa44 STOICHIOMETRY ID COMPLEX
component stoichiometry: 18S s116 sa46 STOICHIOMETRY ID COMPLEX
component stoichiometry: RNA Polymerase I Complex s109 a95 STOICHIOMETRY ID COMPLEX
component stoichiometry: Terminator elements s118 sa49 STOICHIOMETRY ID COMPLEX
component stoichiometry: gene s115 sa45 STOICHIOMETRY ID COMPLEX
component stoichiometry: UCE s113 sa43 STOICHIOMETRY ID COMPLEX
component: Terminator elements
component: PTRF
component: RNA Polymerase I Complex
component: gene
component: TTF-I
component: 18S
component: Promoter
component: UCE
component: rRNA
component: 28S
feature: COMPLEX BINDING FEATURE s108 a93 251
feature: COMPLEX BINDING FEATURE s108 a93 253
feature: COMPLEX BINDING FEATURE s108 a93 261
feature: COMPLEX BINDING FEATURE s108 a93 259
feature: COMPLEX BINDING FEATURE s108 a93 249
feature: COMPLEX BINDING FEATURE s108 a93 247
feature: COMPLEX BINDING FEATURE s108 a93 257
feature: COMPLEX BINDING FEATURE s108 a93 263
feature: COMPLEX BINDING FEATURE s108 a93 255
feature: COMPLEX BINDING FEATURE s108 a93 265

DNA-directed RNA polymerase I subunit RPA2
type: ProteinReference
xref: PTHR20856:SF5
xref: uniprot O74633 61
organism: Neurospora crassa

Promoter
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s71 sa16 182
comment: SPECIES_TYPE=GENE

PTHR46338:SF10
type: RelationshipXref
id: PTHR46338:SF10
db: PANTHER Family
relationship type: By Homology

uniprot H2RA83 58
type: UnificationXref
id: H2RA83
db: uniprot

RNA Polymerase I Complex
type: Protein
entity reference: RNA Polymerase I Complex
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9913 3
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot P25977 120
type: UnificationXref
id: P25977
db: uniprot

RNA Polymerase I Complex s79 a84 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RNA Polymerase I Complex
stoichiometric coefficient: 1.0

TTF I s111 a99 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TTF-I
stoichiometric coefficient: 1.0

TTF-I
type: Protein
entity reference: TTF-I
feature: COMPLEX PARTICIPANT BINDING FEATURE s99 a89 230
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot E2QZE2 47
organism: Canis lupus familiaris

28S s106 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 28S
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot F7G0B2 14
organism: Macaca mulatta

TATA-box binding protein associated factor 8
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot E2RN76 6
organism: Canis lupus familiaris

Leishmania major
type: BioSource
xref: ncbitaxon 5664 152

uniprot Q9LF25 34
type: UnificationXref
id: Q9LF25
db: uniprot

uniprot F7F0J5 88
type: UnificationXref
id: F7F0J5
db: uniprot

TATA box-binding protein-like protein 1
type: ProteinReference
xref: uniprot Q6DIY4 101
xref: PTHR10126:SF55
organism: Xenopus tropicalis

uniprot Q8ZVR0 106
type: UnificationXref
id: Q8ZVR0
db: uniprot

STATE_TRANSITION_LEFT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_SL1_complex-RIGHT__Complex_UCE_Promoter_gene_18S_gene__28S_Terminator_elements_-_r14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 289
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 288
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 290
left: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
left: SL1 complex
interaction type: STATE_TRANSITION
right: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BNE7 121
xref: PTHR15240:SF3
organism: Bos taurus

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 21

Polymerase (RNA) II (DNA directed) polypeptide K
type: ProteinReference
xref: PTHR12056:SF2
xref: uniprot F1RDV9 50
organism: Danio rerio

TTF I s99 a89 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TTF-I
stoichiometric coefficient: 1.0

Promoter s71 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Promoter
stoichiometric coefficient: 1.0

TATA-box-binding protein 2
type: ProteinReference
xref: uniprot P28148 145
xref: PTHR10126:SF54
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY re16 291
type: Stoichiometry
physical entity: UBF1
stoichiometric coefficient: 1.0

UCE
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s52 sa29 164
comment: SPECIES_TYPE=GENE

PARTICIPANT STOICHIOMETRY re16 292
type: Stoichiometry
physical entity: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
stoichiometric coefficient: 1.0

PSMC3 interacting protein
type: ProteinReference
xref: uniprot E2RCC0 132
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY re16 293
type: Stoichiometry
physical entity: Complex(UCE/Promoter/gene/18S/gene/ 28S/Terminator elements)
stoichiometric coefficient: 1.0

DNA-directed RNA polymerases I and III subunit RPAC2
type: ProteinReference
xref: uniprot P28000 67
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r9 294
type: Stoichiometry
physical entity: TAF-IC
stoichiometric coefficient: 1.0

TAF1A isoform 2
type: ProteinReference
xref: PTHR32122:SF1
xref: uniprot H2Q165 43
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r9 295
type: Stoichiometry
physical entity: SL1 complex
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RI73 49
xref: PTHR13946:SF28
organism: Canis lupus familiaris

Promoter s114 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Promoter
stoichiometric coefficient: 1.0

UBF1 s97 a79 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: UBF1
stoichiometric coefficient: 2.0

TAF (TBP-associated transcription factor) family
type: ProteinReference
xref: uniprot Q7YTH5 30
xref: PTHR46469:SF1
organism: Caenorhabditis elegans

UCE
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s70 sa15 180
comment: SPECIES_TYPE=GENE

Uncharacterized protein
type: ProteinReference
xref: PTHR10126:SF37
xref: uniprot F6VEJ6 135
organism: Macaca mulatta

PTHR10126:SF54
type: RelationshipXref
id: PTHR10126:SF54
db: PANTHER Family
relationship type: By Homology

uniprot Q28J24 22
type: UnificationXref
id: Q28J24
db: uniprot

PTHR10126:SF55
type: RelationshipXref
id: PTHR10126:SF55
db: PANTHER Family
relationship type: By Homology

TTF-I
type: Protein
entity reference: TTF-I
comment: SPECIES_TYPE=PROTEIN

uniprot Q7PFI3 157
type: UnificationXref
id: Q7PFI3
db: uniprot

gene s93 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: gene
stoichiometric coefficient: 2.0

18S
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s105 sa39 242
comment: SPECIES_TYPE=GENE

Transcription initiation factor TFIID subunit 8
type: ProteinReference
xref: PTHR46469:SF1
xref: uniprot A7MAZ4 2
organism: Bos taurus

UNKNOWN_TRANSITION_LEFT__TAF_IC-RIGHT__SL1_complex-_r9
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 294
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 295
left: TAF-IC
interaction type: UNKNOWN_TRANSITION
right: SL1 complex

18S s83 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 18S
stoichiometric coefficient: 1.0

uniprot P85125 125
type: UnificationXref
id: P85125
db: uniprot