UNKNOWN_TRANSITION_LEFT__ERK1_2-RIGHT__p65-_re496
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re496 878
participant stoichiometry: PARTICIPANT STOICHIOMETRY re496 879
left: ERK1/2
interaction type: UNKNOWN_TRANSITION
right: p65

CNP
type: DnaRegionReference
member entity reference: C-type natriuretic peptide
xref: G06905
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.CNP
comment: ENTITY_REFERENCE_NOTES=Nppc: GeneID: 18159

PLCbeta
type: Protein
entity reference: PLCbeta
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Runx2
type: Protein
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

MASH1
type: Protein
entity reference: MASH1
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Fosb
type: RnaRegion
entity reference: Fosb
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

NF-Y_JUN_FOS
type: Complex
component stoichiometry: NF Y s310 sa202 STOICHIOMETRY ID COMPLEX
component stoichiometry: FOS s150 sa203 STOICHIOMETRY ID COMPLEX
component stoichiometry: JUN s152 sa212 STOICHIOMETRY ID COMPLEX
component: FOS
component: NF-Y
component: JUN
feature: COMPLEX BINDING FEATURE s755 csa4 344
feature: COMPLEX BINDING FEATURE s755 csa4 346
feature: COMPLEX BINDING FEATURE s755 csa4 348
cellular location: Nucleus

Prostaglandin F2-alpha receptor
type: ProteinReference
xref: uniprot P43117 145
organism: Mus musculus

uniprot Q00417 70
type: UnificationXref
id: Q00417
db: uniprot

STATE_TRANSITION_LEFT__p38-RIGHT__COX2-_re497
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re497 876
participant stoichiometry: PARTICIPANT STOICHIOMETRY re497 877
left: p38
interaction type: STATE_TRANSITION
right: COX2

PARTICIPANT STOICHIOMETRY re654 642
type: Stoichiometry
physical entity: 3' FSHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re646 661
type: Stoichiometry
physical entity: ATF2
stoichiometric coefficient: 1.0

TRANSLATION_LEFT__Isl_1-RIGHT__Isl_1-_re525
type: TemplateReaction
product: Isl-1
xref: TRANSLATION
participant: Isl-1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

PARTICIPANT STOICHIOMETRY re646 662
type: Stoichiometry
physical entity: CGA
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ERK1_2-RIGHT__mPer1-_re326
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re326 576
participant stoichiometry: PARTICIPANT STOICHIOMETRY re326 575
left: ERK1/2
interaction type: STATE_TRANSITION
right: mPer1

gnai/o
type: Protein
entity reference: gnai/o
feature: COMPLEX PARTICIPANT BINDING FEATURE s163 sa219 333
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

mPer1
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.mPer1
comment: ENTITY_REFERENCE_NOTES=GeneID: 18626

PARTICIPANT STOICHIOMETRY re654 641
type: Stoichiometry
physical entity: Nur77_TORC1
stoichiometric coefficient: 1.0

Focal adhesion kinase 1
type: ProteinReference
xref: uniprot P34152 149
xref: PTHR24418:SF78
organism: Mus musculus

STATE_TRANSITION_LEFT__JNK1_2-RIGHT__COX2-_re495
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re495 883
participant stoichiometry: PARTICIPANT STOICHIOMETRY re495 882
left: JNK1/2
interaction type: STATE_TRANSITION
right: COX2

CREB
type: Protein
entity reference: CREB
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Prolactin_PRLR
type: Complex
component stoichiometry: Prolactin s195 sa254 STOICHIOMETRY ID COMPLEX
component stoichiometry: PRLR s381 sa396 STOICHIOMETRY ID COMPLEX
component: Prolactin
component: PRLR
feature: COMPLEX BINDING FEATURE s772 csa41 376
feature: COMPLEX BINDING FEATURE s772 csa41 374
cellular location: Cytoplasm

Transcription factor p65
type: ProteinReference
xref: PTHR24169:SF1
xref: uniprot Q04206 39
organism: Homo sapiens

TRANSLATION_LEFT__Isl_1-RIGHT__Isl_1-_re524
type: TemplateReaction
product: Isl-1
xref: TRANSLATION
participant: Isl-1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

TRANSLATION_LEFT__Zeb1-RIGHT__Zeb1-_re291
type: TemplateReaction
product: Zeb1
xref: TRANSLATION
participant: Zeb1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

PTHR24248:SF87
type: RelationshipXref
id: PTHR24248:SF87
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__PKCs-RIGHT__MAP2K1_2-_re424
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re424 993
participant stoichiometry: PARTICIPANT STOICHIOMETRY re424 992
left: PKCs
interaction type: STATE_TRANSITION
right: MAP2K1/2

PARTICIPANT STOICHIOMETRY re43 715
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

uniprot Q60765 73
type: UnificationXref
id: Q60765
db: uniprot

PARTICIPANT STOICHIOMETRY re43 714
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

uniprot Q60994 12
type: UnificationXref
id: Q60994
db: uniprot

IRS 1 s471 sa488 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IRS-1
stoichiometric coefficient: 1.0

uniprot P70205 15
type: UnificationXref
id: P70205
db: uniprot

uniprot Q9JHD1 111
type: UnificationXref
id: Q9JHD1
db: uniprot

uniprot Q6PAM0 219
type: UnificationXref
id: Q6PAM0
db: uniprot

uniprot Q91Y86 125
type: UnificationXref
id: Q91Y86
db: uniprot

Tubulin s867 sa696 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Tubulin
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__FOS-RIGHT__PACAP-_re614
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re614 766
participant stoichiometry: PARTICIPANT STOICHIOMETRY re614 767
left: FOS
interaction type: STATE_TRANSITION
right: PACAP

PTHR45750:SF2
type: RelationshipXref
id: PTHR45750:SF2
db: PANTHER Family
relationship type: By Homology

uniprot Q9JM73 168
type: UnificationXref
id: Q9JM73
db: uniprot

SMAD1/5/8
type: ProteinReference
xref: P06787
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Smad1: GeneID: 17125; Smad5: GeneID: 17129; Smad8: GeneID: 55994
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.SMAD1/5/8
member entity reference: Mothers against decapentaplegic homolog 1
member entity reference: Mothers against decapentaplegic homolog 9
member entity reference: Mothers against decapentaplegic homolog 5

Mus musculus
type: BioSource
xref: ncbitaxon 10090 7

PTHR24241:SF22
type: RelationshipXref
id: PTHR24241:SF22
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re639 679
type: Stoichiometry
physical entity: SF1
stoichiometric coefficient: 1.0

EGF
type: ProteinReference
xref: P06745
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= GeneID: 13645
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.EGF
member entity reference: Pro-epidermal growth factor

Nur77
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.Nur77
comment: ENTITY_REFERENCE_NOTES=GeneID: 15370

GPR147/74
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s733 sa652 339
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q61411 200
type: UnificationXref
id: Q61411
db: uniprot

PTHR11269:SF8
type: RelationshipXref
id: PTHR11269:SF8
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__gnas-RIGHT__AC-_re362
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re362 536
participant stoichiometry: PARTICIPANT STOICHIOMETRY re362 535
left: gnas
interaction type: STATE_TRANSITION
right: AC

uniprot O09108 135
type: UnificationXref
id: O09108
db: uniprot

ActRII/IIB
type: ProteinReference
xref: P06780
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.ActRII/IIB
comment: ENTITY_REFERENCE_NOTES=Activin receptor IIA: GeneID: 11480; Activin receptor IIB: GeneID: 11481
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Activin receptor type-2A
member entity reference: Activin receptor type-2B

PARTICIPANT STOICHIOMETRY re577 779
type: Stoichiometry
physical entity: NFAT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re577 778
type: Stoichiometry
physical entity: Caln
stoichiometric coefficient: 1.0

uniprot Q04998 127
type: UnificationXref
id: Q04998
db: uniprot

PARTICIPANT STOICHIOMETRY re639 680
type: Stoichiometry
physical entity: 5' LHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re485 908
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re485 909
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__mPer1-RIGHT__mPer1-_re458
type: TemplateReaction
product: mPer1
xref: TRANSCRIPTION
participant: mPer1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

CTNNB1
type: Protein
entity reference: CTNNB1
feature: COMPLEX PARTICIPANT BINDING FEATURE s533 sa407 369
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re298 570
type: Stoichiometry
physical entity: Junc
stoichiometric coefficient: 1.0

PTHR10218:SF316
type: RelationshipXref
id: PTHR10218:SF316
db: PANTHER Family
relationship type: By Homology

Isl-1
type: ProteinReference
xref: P06791
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Gene ID: 16392
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Isl-1
member entity reference: Insulin gene enhancer protein ISL-1

PARTICIPANT STOICHIOMETRY re265 625
type: Stoichiometry
physical entity: EIF2AK3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re265 626
type: Stoichiometry
physical entity: EIF2AK3
stoichiometric coefficient: 2.0

UNKNOWN_TRANSITION_LEFT__PKCs-RIGHT__FOS_JUN-_FOS_Jund-_re283
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re283 591
participant stoichiometry: PARTICIPANT STOICHIOMETRY re283 592
participant stoichiometry: PARTICIPANT STOICHIOMETRY re283 593
left: PKCs
interaction type: UNKNOWN_TRANSITION
right: FOS_Jund
right: FOS_JUN

PARTICIPANT STOICHIOMETRY re298 569
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

?
type: Protein
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PAC1R
type: RnaRegion
entity reference: PAC1R
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

EGFR
type: Protein
entity reference: EGFR
feature: COMPLEX PARTICIPANT BINDING FEATURE s53 sa99 301
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P70314 203
type: UnificationXref
id: P70314
db: uniprot

PTHR10218:SF320
type: RelationshipXref
id: PTHR10218:SF320
db: PANTHER Family
relationship type: By Homology

uniprot P31750 69
type: UnificationXref
id: P31750
db: uniprot

JUN
type: ProteinReference
xref: P06757
comment: ENTITY_REFERENCE_NOTES= Junc: GeneID: 16476 ; Junb: GeneID: 16477
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.JUN
member entity reference: Transcription factor jun-B
member entity reference: Transcription factor AP-1

Cdc42
type: ProteinReference
xref: P06743
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= GeneID: 12540
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Cdc42
member entity reference: Cell division control protein 42 homolog

uniprot O08648 152
type: UnificationXref
id: O08648
db: uniprot

Ras
type: ProteinReference
xref: P06753
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 15461
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Ras
member entity reference: GTPase HRas

PARTICIPANT STOICHIOMETRY re490 890
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re328 574
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re490 891
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re328 573
type: Stoichiometry
physical entity: nPKCs
stoichiometric coefficient: 1.0

Leptin s639 sa568 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Leptin
stoichiometric coefficient: 1.0

PTHR10218:SF328
type: RelationshipXref
id: PTHR10218:SF328
db: PANTHER Family
relationship type: By Homology

EIF2AK3 s217 sa271 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EIF2AK3
stoichiometric coefficient: 2.0

uniprot P20722 60
type: UnificationXref
id: P20722
db: uniprot

uniprot Q99JI6 50
type: UnificationXref
id: Q99JI6
db: uniprot

STATE_TRANSITION_LEFT__MAP2K1_2-RIGHT__MEK1_2-_re425
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re425 991
participant stoichiometry: PARTICIPANT STOICHIOMETRY re425 990
left: MAP2K1/2
interaction type: STATE_TRANSITION
right: MEK1/2

…
type: Stoichiometry
physical entity: alpha-beta integrin dimer
stoichiometric coefficient: 2.0

OTX s291 sa341 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: OTX
stoichiometric coefficient: 1.0

CREB_TORC1
type: Complex
component stoichiometry: TORC1 s748 sa670 STOICHIOMETRY ID COMPLEX
component stoichiometry: CREB s747 sa669 STOICHIOMETRY ID COMPLEX
component: CREB
component: TORC1
feature: COMPLEX BINDING FEATURE s760 csa33 262
feature: COMPLEX BINDING FEATURE s760 csa33 264
cellular location: Nucleus

Fosb
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.Fosb
comment: ENTITY_REFERENCE_NOTES=GeneID: 14282

5'-AMP-activated protein kinase subunit gamma-2
type: ProteinReference
xref: uniprot Q91WG5 220
organism: Mus musculus

Follistatin
type: DnaRegion
entity reference: Follistatin
feature: CRE Follistatin s251 sa314 tr1
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

STATE_TRANSITION_LEFT__FAK-RIGHT__FAK-_re597
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re597 699
participant stoichiometry: PARTICIPANT STOICHIOMETRY re597 700
left: FAK
interaction type: STATE_TRANSITION
right: FAK

STATE_TRANSITION_LEFT__ERK1_2-RIGHT__5_QUOTE_SINGLE_LHbeta-_re559
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re559 841
participant stoichiometry: PARTICIPANT STOICHIOMETRY re559 840
left: ERK1/2
interaction type: STATE_TRANSITION
right: 5' LHbeta

Ca2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

STATE_TRANSITION_LEFT__SNURF-RIGHT__SP1-_re393
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re393 980
participant stoichiometry: PARTICIPANT STOICHIOMETRY re393 981
left: SNURF
interaction type: STATE_TRANSITION
right: SP1

uniprot Q3U1V8 158
type: UnificationXref
id: Q3U1V8
db: uniprot

MKK4/7
type: ProteinReference
xref: P06760
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.MKK4/7
comment: ENTITY_REFERENCE_NOTES=MKK4: GeneID: 26398 ; MKK7: GeneID: 26400
member entity reference: Dual specificity mitogen-activated protein kinase kinase 4
member entity reference: Dual specificity mitogen-activated protein kinase kinase 7

Tubulin alpha-1C chain
type: ProteinReference
xref: uniprot P68373 132
organism: Mus musculus

IGF-1
type: Protein
entity reference: IGF-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s469 sa482 487
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P05480 172
type: UnificationXref
id: P05480
db: uniprot

Inhibin heterodimer
type: Complex
component stoichiometry: Inhba b s707 sa639 STOICHIOMETRY ID COMPLEX
component stoichiometry: Inha s706 sa638 STOICHIOMETRY ID COMPLEX
component: Inhba/b
component: Inha
feature: COMPLEX BINDING FEATURE s708 csa25 360
feature: COMPLEX BINDING FEATURE s708 csa25 358
cellular location: Cytoplasm

PARTICIPANT STOICHIOMETRY re243 676
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

RICS
type: Protein
entity reference: RICS
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re243 677
type: Stoichiometry
physical entity: ATF2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re243 678
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re216 784
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

Cdc42_GTP
type: Complex
component stoichiometry: GTP s845 sa683 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cdc42 s265 sa264 STOICHIOMETRY ID COMPLEX
component: GTP
component: Cdc42
feature: COMPLEX BINDING FEATURE s844 csa73 354
feature: COMPLEX BINDING FEATURE s844 csa73 356
cellular location: Cytoplasm

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot P41969 197
organism: Mus musculus

STATE_TRANSITION_LEFT__Pyk2-RIGHT__alpha_beta_integrin_dimer-_re477
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re477 925
participant stoichiometry: PARTICIPANT STOICHIOMETRY re477 924
left: Pyk2
interaction type: STATE_TRANSITION
right: alpha-beta integrin dimer

PARTICIPANT STOICHIOMETRY re216 785
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

Nuclear receptor subfamily 4 group A member 1
type: DnaReference
organism: Mus musculus

CREB s747 sa669 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

Insulin
type: Protein
entity reference: Insulin
feature: COMPLEX PARTICIPANT BINDING FEATURE s193 sa252 415
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P53690 167
type: UnificationXref
id: P53690
db: uniprot

uniprot P63001 225
type: UnificationXref
id: P63001
db: uniprot

EGR1
type: Protein
entity reference: EGR1
feature: COMPLEX PARTICIPANT BINDING FEATURE s833 sa688 441
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

MEK1/2
type: Protein
entity reference: MEK1/2
feature: COMPLEX PARTICIPANT BINDING FEATURE s859 sa529 321
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

UNKNOWN_TRANSITION_LEFT__p38-RIGHT__5_QUOTE_SINGLE_FSHbeta-_re227
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re227 747
participant stoichiometry: PARTICIPANT STOICHIOMETRY re227 746
left: p38
interaction type: UNKNOWN_TRANSITION
right: 5' FSHbeta

NO
type: SmallMolecule
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Inhba b s707 sa639 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Inhba/b
stoichiometric coefficient: 1.0

Prep1 s138 sa198 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Prep1
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION
type: Control
xref: UNKNOWN TRANSITION
controlled: LH secretion
controller: 5-HT3AR

PTHR24356:SF365
type: RelationshipXref
id: PTHR24356:SF365
db: PANTHER Family
relationship type: By Homology

TRANSPORT_LEFT__ERK1_2-RIGHT__ERK1_2-_re113
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re113 932
participant stoichiometry: PARTICIPANT STOICHIOMETRY re113 933
left: ERK1/2
interaction type: TRANSPORT
right: ERK1/2

CREB
type: ProteinReference
xref: P06749
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 12912
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.CREB
member entity reference: Cyclic AMP-responsive element-binding protein 1

Peroxisome proliferator-activated receptor gamma
type: ProteinReference
xref: uniprot P37238 89
organism: Mus musculus

Dopamine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s194 sa253 335
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q66L42 162
type: UnificationXref
id: Q66L42
db: uniprot

PARTICIPANT STOICHIOMETRY re319 597
type: Stoichiometry
physical entity: MKK3/6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re319 596
type: Stoichiometry
physical entity: MAP3Ks
stoichiometric coefficient: 1.0

LHX2
type: ProteinReference
xref: P06756
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.LHX2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 16870 PMID: 17005264
member entity reference: LIM/homeobox protein Lhx2

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q63844 30
xref: PTHR24055:SF393
organism: Mus musculus

Protein-tyrosine kinase 2-beta
type: ProteinReference
xref: uniprot Q9QVP9 173
xref: PTHR24418:SF94
organism: Mus musculus

uniprot P05627 227
type: UnificationXref
id: P05627
db: uniprot

STATE_TRANSITION_LEFT__MEK1_2-RIGHT__ERK1_2-_re555
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re555 846
participant stoichiometry: PARTICIPANT STOICHIOMETRY re555 847
left: MEK1/2
interaction type: STATE_TRANSITION
right: ERK1/2

gnaq/11
type: Protein
entity reference: gnaq/11
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 261
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Achaete-scute homolog 1
type: ProteinReference
xref: uniprot Q02067 196
organism: Mus musculus

FOS s599 sa506 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

Tubulin alpha-1A chain
type: ProteinReference
xref: uniprot P68369 131
organism: Mus musculus

PTHR10844:SF18
type: RelationshipXref
id: PTHR10844:SF18
db: PANTHER Family
relationship type: By Homology

FAK
type: ProteinReference
xref: P06707
comment: ENTITY_REFERENCE_NOTES= GeneID: 14083
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.FAK
member entity reference: Focal adhesion kinase 1

STATE_TRANSITION_LEFT__Isl_1-RIGHT__5_QUOTE_SINGLE_LHbeta-_re627
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re627 722
participant stoichiometry: PARTICIPANT STOICHIOMETRY re627 723
left: Isl-1
interaction type: STATE_TRANSITION
right: 5' LHbeta

UNKNOWN_TRANSITION_LEFT__LTs-RIGHT__CGA-_re339
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re339 556
participant stoichiometry: PARTICIPANT STOICHIOMETRY re339 555
left: LTs
interaction type: UNKNOWN_TRANSITION
right: CGA

Paxillin s853 sa523 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

PKCs(3)
type: Protein
entity reference: PKCs(3)
feature: COMPLEX PARTICIPANT BINDING FEATURE s858 sa528 319
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P11881 92
type: UnificationXref
id: P11881
db: uniprot

EGF_EGFR
type: Complex
component stoichiometry: EGF s219 sa274 STOICHIOMETRY ID COMPLEX
component stoichiometry: EGFR s53 sa99 STOICHIOMETRY ID COMPLEX
component: EGF
component: EGFR
feature: COMPLEX BINDING FEATURE s778 csa47 302
feature: COMPLEX BINDING FEATURE s778 csa47 300
cellular location: Cytoplasm

IRS-1
type: Protein
entity reference: IRS-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s471 sa488 417
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

eco ECO:0000245 20
type: UnificationXref
id: ECO:0000245
db: eco

PARTICIPANT STOICHIOMETRY re205 824
type: Stoichiometry
physical entity: 5' FSHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re205 823
type: Stoichiometry
physical entity: MISRII
stoichiometric coefficient: 1.0

uniprot P28563 235
type: UnificationXref
id: P28563
db: uniprot

PARTICIPANT STOICHIOMETRY re417 1005
type: Stoichiometry
physical entity: 5' FSHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re417 1004
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

ECM_alpha-beta integrin dimer
type: Complex
component stoichiometry: ECM s787 sa360 STOICHIOMETRY ID COMPLEX
component: ECM
component: alpha-beta integrin dimer
feature: COMPLEX BINDING FEATURE s782 csa51 386
feature: COMPLEX BINDING FEATURE s782 csa51 388
cellular location: Cytoplasm

uniprot Q62245 37
type: UnificationXref
id: Q62245
db: uniprot

Id3
type: ProteinReference
xref: P06711
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Id3
comment: ENTITY_REFERENCE_NOTES= GeneID: 15903
member entity reference: DNA-binding protein inhibitor ID-3

STATE_TRANSITION_LEFT__AA-RIGHT__12_LO-_re336
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re336 559
participant stoichiometry: PARTICIPANT STOICHIOMETRY re336 560
left: AA
interaction type: STATE_TRANSITION
right: 12-LO

HETERODIMER_ASSOCIATION_LEFT__SRC_immune_complex-_GnRH-RIGHT__GnRH_SRC_immune_complex-_re661
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re661 614
participant stoichiometry: PARTICIPANT STOICHIOMETRY re661 613
participant stoichiometry: PARTICIPANT STOICHIOMETRY re661 612
left: SRC immune complex
left: GnRH
interaction type: HETERODIMER_ASSOCIATION
right: GnRH_SRC immune complex

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: PTHR46716:SF1
xref: uniprot Q62073 150
organism: Mus musculus

PTHR46037:SF4
type: RelationshipXref
id: PTHR46037:SF4
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re649 655
type: Stoichiometry
physical entity: GR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re649 656
type: Stoichiometry
physical entity: 5' FSHbeta
stoichiometric coefficient: 1.0

00696
type: UnificationXref
id: MOD:00696
db: mod

TRANSCRIPTION_LEFT__PAC1R-RIGHT__PAC1R-_re519
type: TemplateReaction
product: PAC1R
xref: TRANSCRIPTION
participant: PAC1R
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

HETERODIMER_ASSOCIATION_LEFT__EGR1-_p300-_SF1-RIGHT__EGR1_p300_SF1-_re638
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re638 681
participant stoichiometry: PARTICIPANT STOICHIOMETRY re638 684
participant stoichiometry: PARTICIPANT STOICHIOMETRY re638 683
participant stoichiometry: PARTICIPANT STOICHIOMETRY re638 682
left: p300
left: SF1
left: EGR1
interaction type: HETERODIMER_ASSOCIATION
right: EGR1_p300_SF1

PARTICIPANT STOICHIOMETRY re600 822
type: Stoichiometry
physical entity: CNP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re600 821
type: Stoichiometry
physical entity: SP1_SP3
stoichiometric coefficient: 1.0

Pyk2
type: Protein
entity reference: Pyk2
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Serum response factor
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot Q9JM73 168
organism: Mus musculus

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot Q60631 236
xref: PTHR46037:SF4
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re613 768
type: Stoichiometry
physical entity: FOS_Jund
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re613 769
type: Stoichiometry
physical entity: PACAP
stoichiometric coefficient: 1.0

PTHR46716:SF1
type: RelationshipXref
id: PTHR46716:SF1
db: PANTHER Family
relationship type: By Homology

Id2 s632 sa563 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Id2
stoichiometric coefficient: 1.0

PE
type: SmallMolecule
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

UNKNOWN_TRANSITION_LEFT__PKCs-RIGHT__CNP-_re456
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re456 954
participant stoichiometry: PARTICIPANT STOICHIOMETRY re456 955
left: PKCs
interaction type: UNKNOWN_TRANSITION
right: CNP

STATE_TRANSITION_LEFT__PLCbeta-RIGHT__DAG-_re18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 829
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 830
left: PLCbeta
interaction type: STATE_TRANSITION
right: DAG

PTHR19850:SF27
type: RelationshipXref
id: PTHR19850:SF27
db: PANTHER Family
relationship type: By Homology

UNKNOWN_TRANSITION_LEFT__ERK1_2-RIGHT__Glut1-_re563
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re563 827
participant stoichiometry: PARTICIPANT STOICHIOMETRY re563 828
left: ERK1/2
interaction type: UNKNOWN_TRANSITION
right: Glut1

Prx2
type: Protein
entity reference: Prx2
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

BMP6/7
type: Protein
entity reference: BMP6/7
feature: COMPLEX PARTICIPANT BINDING FEATURE s687 sa617 401
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q8BPM2 19
type: UnificationXref
id: Q8BPM2
db: uniprot

uniprot Q3V3R4 137
type: UnificationXref
id: Q3V3R4
db: uniprot

JAK1 s640 sa569 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JAK1
stoichiometric coefficient: 1.0

GnRH
type: Protein
entity reference: GnRH
feature: COMPLEX PARTICIPANT BINDING FEATURE s850 sa256 299
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

CBP
type: ProteinReference
xref: P06755
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.CBP
comment: ENTITY_REFERENCE_NOTES=GeneID: 12914
member entity reference: CREB-binding protein

KSR-1
type: Protein
entity reference: KSR-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s857 sa527 317
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P15208 35
type: UnificationXref
id: P15208
db: uniprot

STATE_TRANSITION_LEFT__GR-RIGHT__5_QUOTE_SINGLE_FSHbeta-_re649
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re649 656
participant stoichiometry: PARTICIPANT STOICHIOMETRY re649 655
left: GR
interaction type: STATE_TRANSITION
right: 5' FSHbeta

ActRII/IIB
type: Protein
entity reference: ActRII/IIB
feature: COMPLEX PARTICIPANT BINDING FEATURE s728 sa648 277
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re332 566
type: Stoichiometry
physical entity: SMAD2-4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re332 565
type: Stoichiometry
physical entity: SMAD2-4
stoichiometric coefficient: 1.0

Evidence 231
type: Evidence
evidence code: RCA
comment: SPACC P50393

uniprot Q60631 236
type: UnificationXref
id: Q60631
db: uniprot

uniprot P62874 192
type: UnificationXref
id: P62874
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__cAMP-_re43
control type: INHIBITION
controller: gnai/o

STATE_TRANSITION_LEFT__NFAT-RIGHT__Nur77-_re610
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re610 777
participant stoichiometry: PARTICIPANT STOICHIOMETRY re610 776
left: NFAT
interaction type: STATE_TRANSITION
right: Nur77

PTHR19850:SF29
type: RelationshipXref
id: PTHR19850:SF29
db: PANTHER Family
relationship type: By Homology

PTHR19850:SF28
type: RelationshipXref
id: PTHR19850:SF28
db: PANTHER Family
relationship type: By Homology

UNKNOWN_TRANSITION_LEFT__NFAT-RIGHT__CGA-_re583
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re583 757
participant stoichiometry: PARTICIPANT STOICHIOMETRY re583 756
left: NFAT
interaction type: UNKNOWN_TRANSITION
right: CGA

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s845 sa683 357
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PAC1R
type: DnaRegion
entity reference: PAC1R
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

uniprot P21278 101
type: UnificationXref
id: P21278
db: uniprot

Prostaglandin E2 receptor EP2 subtype
type: ProteinReference
xref: uniprot Q62053 147
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re282 594
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

uniprot P41136 65
type: UnificationXref
id: P41136
db: uniprot

Astrocytic phosphoprotein PEA-15
type: ProteinReference
xref: uniprot Q62048 74
organism: Mus musculus

Unknown GPCR s651 sa582 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Unknown GPCR
stoichiometric coefficient: 1.0

COX2
type: RnaRegion
entity reference: COX2
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

Follistatin
type: Protein
entity reference: Follistatin
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P80205 98
type: UnificationXref
id: P80205
db: uniprot

Nuclear transcription factor Y subunit gamma
type: ProteinReference
xref: uniprot P70353 11
organism: Mus musculus

GnRHR
type: ProteinReference
xref: P06727
comment: ENTITY_REFERENCE_NOTES= GeneID: 14715
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.GnRHR
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Gonadotropin-releasing hormone receptor

STATE_TRANSITION_LEFT__JNK1_2-RIGHT__3_QUOTE_SINGLE_FSHbeta-_re387
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re387 1000
participant stoichiometry: PARTICIPANT STOICHIOMETRY re387 1001
left: JNK1/2
interaction type: STATE_TRANSITION
right: 3' FSHbeta

TRANSCRIPTION_LEFT__Nur77-RIGHT__Nur77-_re422
type: TemplateReaction
product: Nur77
xref: TRANSCRIPTION
participant: Nur77
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PARTICIPANT STOICHIOMETRY re282 595
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

SP1_SP3
type: Complex
component stoichiometry: SP3 s478 sa500 STOICHIOMETRY ID COMPLEX
component stoichiometry: SP1 s818 sa499 STOICHIOMETRY ID COMPLEX
component: SP3
component: SP1
feature: COMPLEX BINDING FEATURE s817 csa60 502
feature: COMPLEX BINDING FEATURE s817 csa60 500
cellular location: Nucleus

PARTICIPANT STOICHIOMETRY re266 624
type: Stoichiometry
physical entity: EIF2A
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re266 623
type: Stoichiometry
physical entity: EIF2AK3
stoichiometric coefficient: 2.0

uniprot P97819 232
type: UnificationXref
id: P97819
db: uniprot

JUN s479 sa505 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

uniprot P97474 204
type: UnificationXref
id: P97474
db: uniprot

uniprot P63213 198
type: UnificationXref
id: P63213
db: uniprot

PARTICIPANT STOICHIOMETRY re552 850
type: Stoichiometry
physical entity: SMAD1/5/8
stoichiometric coefficient: 1.0

FAK
type: Protein
entity reference: FAK
feature: COMPLEX PARTICIPANT BINDING FEATURE s856 sa526 315
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re552 851
type: Stoichiometry
physical entity: SMAD1/5/8
stoichiometric coefficient: 1.0

Transforming growth factor beta-1 proprotein
type: ProteinReference
xref: PTHR11848:SF125
xref: uniprot P04202 47
organism: Mus musculus

PTHR45976:SF4
type: RelationshipXref
id: PTHR45976:SF4
db: PANTHER Family
relationship type: By Homology

uniprot P01132 175
type: UnificationXref
id: P01132
db: uniprot

PARTICIPANT STOICHIOMETRY re575 787
type: Stoichiometry
physical entity: Alk4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re575 788
type: Stoichiometry
physical entity: Activin A homodimer
stoichiometric coefficient: 1.0

Junc
type: RnaRegionReference
comment: ENTITY_REFERENCE_NOTES=GeneID: 16476
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.Junc

PARTICIPANT STOICHIOMETRY re575 786
type: Stoichiometry
physical entity: Activin A homodimer
stoichiometric coefficient: 1.0

uniprot P63328 199
type: UnificationXref
id: P63328
db: uniprot

PTHR44329:SF39
type: RelationshipXref
id: PTHR44329:SF39
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re593 703
type: Stoichiometry
physical entity: Rac1
stoichiometric coefficient: 1.0

Alk4_ActivinA_ActRII/IIB
type: Complex
component stoichiometry: Activin A homodimer s729 csa31 STOICHIOMETRY ID COMPLEX
component stoichiometry: ActRII IIB s728 sa648 STOICHIOMETRY ID COMPLEX
component stoichiometry: Alk4 s709 sa640 STOICHIOMETRY ID COMPLEX
component: ActRII/IIB
component: Activin A homodimer
component: Alk4
feature: COMPLEX BINDING FEATURE s770 csa30 274
feature: COMPLEX BINDING FEATURE s770 csa30 276
feature: COMPLEX BINDING FEATURE s770 csa30 272
cellular location: Cytoplasm

UNKNOWN_TRANSITION_LEFT__Linoleate-RIGHT__MEK1_2-_re557
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re557 844
participant stoichiometry: PARTICIPANT STOICHIOMETRY re557 845
left: Linoleate
interaction type: UNKNOWN_TRANSITION
right: MEK1/2

PARTICIPANT STOICHIOMETRY re593 704
type: Stoichiometry
physical entity: MAP4Ks
stoichiometric coefficient: 1.0

PTHR10218:SF302
type: RelationshipXref
id: PTHR10218:SF302
db: PANTHER Family
relationship type: By Homology

Insulin gene enhancer protein ISL-1
type: ProteinReference
xref: uniprot P61372 41
organism: Mus musculus

PTHR10155:SF3
type: RelationshipXref
id: PTHR10155:SF3
db: PANTHER Family
relationship type: By Homology

Mothers against decapentaplegic homolog 1
type: ProteinReference
xref: uniprot P70340 112
xref: PTHR13703:SF23
organism: Mus musculus

PTHR19850:SF36
type: RelationshipXref
id: PTHR19850:SF36
db: PANTHER Family
relationship type: By Homology

Rap1b
type: Protein
entity reference: Rap1b
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR19850:SF31
type: RelationshipXref
id: PTHR19850:SF31
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re623 730
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re623 731
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__cGMP-RIGHT__CGA-_re430
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re430 973
participant stoichiometry: PARTICIPANT STOICHIOMETRY re430 972
left: cGMP
interaction type: STATE_TRANSITION
right: CGA

uniprot O70477 23
type: UnificationXref
id: O70477
db: uniprot

Glut1
type: RnaRegion
entity reference: Glut1
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

PARTICIPANT STOICHIOMETRY re653 644
type: Stoichiometry
physical entity: 3' FSHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re653 643
type: Stoichiometry
physical entity: AR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re543 864
type: Stoichiometry
physical entity: Ca/CaMK II
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re543 865
type: Stoichiometry
physical entity: SRF
stoichiometric coefficient: 1.0

Adiponectin s202 sa260 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Adiponectin
stoichiometric coefficient: 1.0

PTHR44329:SF22
type: RelationshipXref
id: PTHR44329:SF22
db: PANTHER Family
relationship type: By Homology

Paxillin
type: Protein
entity reference: Paxillin
feature: COMPLEX PARTICIPANT BINDING FEATURE s853 sa523 309
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

FOS
type: ProteinReference
xref: P06709
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= c-fos: GeneID: 14281 ; Fosb: GeneID: 14282
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.FOS
member entity reference: Proto-oncogene c-Fos
member entity reference: Protein fosB

GR
type: Protein
entity reference: GR
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re20 800
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

Homeobox protein PKNOX1
type: ProteinReference
xref: uniprot O70477 23
organism: Mus musculus

Homeobox protein TGIF1
type: ProteinReference
xref: uniprot Q15583 72
organism: Homo sapiens

COX2
type: Protein
entity reference: COX2
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__SMAD2_4-RIGHT__SMAD2_4-_re551
control type: INHIBITION
controller: Resveratrol

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__ActRII_IIB-RIGHT__Activin_A_homodimer-_re572
control type: INHIBITION
controller: Inhba/b

uniprot P15066 240
type: UnificationXref
id: P15066
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63213 198
xref: PTHR13809:SF25
organism: Mus musculus

Gbeta_Ggamma
type: Complex
component stoichiometry: Gbeta s619 sa552 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s620 sa553 STOICHIOMETRY ID COMPLEX
component: Gbeta
component: Ggamma
feature: COMPLEX BINDING FEATURE s754 csa21 380
feature: COMPLEX BINDING FEATURE s754 csa21 378
cellular location: Nucleus

STATE_TRANSITION_LEFT__Isl_1-RIGHT__3_QUOTE_SINGLE_FSHbeta-_re647
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re647 659
participant stoichiometry: PARTICIPANT STOICHIOMETRY re647 660
left: Isl-1
interaction type: STATE_TRANSITION
right: 3' FSHbeta

STATE_TRANSITION_LEFT__ERK1_2-RIGHT__DUSP1-_re426
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re426 989
participant stoichiometry: PARTICIPANT STOICHIOMETRY re426 988
left: ERK1/2
interaction type: STATE_TRANSITION
right: DUSP1

PGs
type: SmallMolecule
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__p38-RIGHT__3_QUOTE_SINGLE_FSHbeta-_re388
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re388 997
participant stoichiometry: PARTICIPANT STOICHIOMETRY re388 996
left: p38
interaction type: STATE_TRANSITION
right: 3' FSHbeta

CTNNB1
type: Protein
entity reference: CTNNB1
feature: COMPLEX PARTICIPANT BINDING FEATURE s396 sa410 445
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot O54718 181
type: UnificationXref
id: O54718
db: uniprot

Atf3
type: Protein
entity reference: Atf3
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

ER s609 sa464 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ER
stoichiometric coefficient: 1.0

NOSI
type: Protein
entity reference: NOSI
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PGs s629 sa562 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PGs
stoichiometric coefficient: 1.0

PKCs 3 s858 sa528 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PKCs(3)
stoichiometric coefficient: 1.0

uniprot P20444 25
type: UnificationXref
id: P20444
db: uniprot

TRANSLATION_LEFT__FSHbeta-RIGHT__FSHbeta-_re526
type: TemplateReaction
product: FSHbeta
xref: TRANSLATION
participant: FSHbeta
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

PARTICIPANT STOICHIOMETRY re498 873
type: Stoichiometry
physical entity: NOSI
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re498 872
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

TCF
type: ProteinReference
xref: P06701
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.TCF
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Tcf7: GeneID: 21414 ; Tcf3: GeneID: 21415
member entity reference: Transcription factor 7
member entity reference: Transcription factor 7-like 1

STATE_TRANSITION
type: Control
xref: STATE TRANSITION
controlled: Vesicular secretion
controller: Ca2+

Pituitary homeobox 1
type: ProteinReference
xref: uniprot P70314 203
organism: Mus musculus

Adenylate cyclase type 1
type: ProteinReference
xref: PTHR45627:SF12
xref: uniprot O88444 207
organism: Mus musculus

EGR1
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.EGR1
comment: ENTITY_REFERENCE_NOTES=GeneID: 13653

PARTICIPANT STOICHIOMETRY re442 967
type: Stoichiometry
physical entity: Inhba/b
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re442 966
type: Stoichiometry
physical entity: TBRIII
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__GTP-RIGHT__Rac1-_re539
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re539 869
participant stoichiometry: PARTICIPANT STOICHIOMETRY re539 868
left: GTP
interaction type: STATE_TRANSITION
right: Rac1

Isl-1
type: Protein
entity reference: Isl-1
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

TBRIII
type: Protein
entity reference: TBRIII
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Serotonin_5-HT3AR
type: Complex
component stoichiometry: Serotonin s198 sa257 STOICHIOMETRY ID COMPLEX
component stoichiometry: 5 HT3AR s124 sa178 STOICHIOMETRY ID COMPLEX
component: Serotonin
component: 5-HT3AR
feature: COMPLEX BINDING FEATURE s773 csa42 426
feature: COMPLEX BINDING FEATURE s773 csa42 428
cellular location: Cytoplasm

PARTICIPANT STOICHIOMETRY re279 605
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

Activin receptor type-2A
type: ProteinReference
xref: PTHR23255:SF64
xref: uniprot P27038 44
organism: Mus musculus

IR
type: Protein
entity reference: IR
feature: COMPLEX PARTICIPANT BINDING FEATURE s192 sa177 413
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

gnai/o
type: ProteinReference
xref: P06773
comment: ENTITY_REFERENCE_NOTES= Gnai1: GeneID: 14677; Gnao1: GeneID: 14681 PMID: 16959402 It shows that dopaminD2 agonists significantly reduce PACAP mediated cAMP production possibly by activating Gai/o.
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.gnai/o
member entity reference: Guanine nucleotide-binding protein G(o) subunit alpha
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

PARTICIPANT STOICHIOMETRY re279 604
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PEA 15 s654 sa585 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

TRANSPORT
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re292 571
type: Stoichiometry
physical entity: IR
stoichiometric coefficient: 1.0

FAK s812 sa684 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

uniprot P63163 239
type: UnificationXref
id: P63163
db: uniprot

PARTICIPANT STOICHIOMETRY re292 572
type: Stoichiometry
physical entity: EGR1
stoichiometric coefficient: 1.0

12-LO
type: Protein
entity reference: 12-LO
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P18872 243
organism: Mus musculus

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 20

p300
type: ProteinReference
xref: P06737
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.p300
comment: ENTITY_REFERENCE_NOTES= GeneID: 328572 PMID: 14681221 PMID: 10318795
member entity reference: Histone acetyltransferase p300

5' FSHbeta
type: DnaRegionReference
member entity reference: Follitropin subunit beta
xref: G06904
comment: ENTITY_REFERENCE_NOTES=GeneID: 14308
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.5' FSHbeta

TRANSCRIPTION_LEFT__COX2-RIGHT__COX2-_re273
type: TemplateReaction
product: COX2
xref: TRANSCRIPTION
participant: COX2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

NFAT
type: Protein
entity reference: NFAT
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P63054 155
type: UnificationXref
id: P63054
db: uniprot

RFRP-1/-3_GPR147/74_gnai
type: Complex
component stoichiometry: GPR147 74 s733 sa652 STOICHIOMETRY ID COMPLEX
component stoichiometry: gnai s735 sa654 STOICHIOMETRY ID COMPLEX
component stoichiometry: RFRP 1 3 s734 sa653 STOICHIOMETRY ID COMPLEX
component: gnai
component: RFRP-1/-3
component: GPR147/74
feature: COMPLEX BINDING FEATURE s781 csa50 340
feature: COMPLEX BINDING FEATURE s781 csa50 338
feature: COMPLEX BINDING FEATURE s781 csa50 342
cellular location: Cytoplasm

uniprot P21274 213
type: UnificationXref
id: P21274
db: uniprot

Atf3
type: ProteinReference
xref: P06821
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Atf3
comment: ENTITY_REFERENCE_NOTES=GeneID: 11910 PMID: 15961508 Transcript profiling of immediate early genes reveals a unique role for activating transcription factor 3 in mediating activation of the glycoprotein hormone alpha-subunit promoter by gonadotropin-releasing hormone. PMID: 22446101 GnRH Regulation of Jun and Atf3 Requires Calcium, Calcineurin, and NFAT.
member entity reference: Cyclic AMP-dependent transcription factor ATF-3

uniprot O88942 104
type: UnificationXref
id: O88942
db: uniprot

ELK1 s678 sa611 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ELK1
stoichiometric coefficient: 1.0

CNP
type: ProteinReference
xref: P06824
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Nppc: GeneID: 18159
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.CNP
member entity reference: C-type natriuretic peptide

Inhba/b
type: ProteinReference
xref: P06700
comment: ENTITY_REFERENCE_NOTES= Inhba: GeneID: 16323; Inhbb: GeneID: 16324
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Inhba/b
member entity reference: Inhibin beta B chain
member entity reference: Inhibin beta A chain

TRANSLATION_LEFT__RICS-RIGHT__RICS-_re535
type: TemplateReaction
product: RICS
xref: TRANSLATION
participant: RICS
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

TRANSCRIPTION_LEFT__3_QUOTE_SINGLE_LHbeta-RIGHT__LHbeta-_re510
type: TemplateReaction
product: LHbeta
xref: TRANSCRIPTION
participant: LHbeta
participant: 3' LHbeta
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

TRANSLATION_LEFT__LHbeta-RIGHT__LHbeta-_re511
type: TemplateReaction
product: LHbeta
xref: TRANSLATION
participant: LHbeta
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

OTX
type: Protein
entity reference: OTX
feature: COMPLEX PARTICIPANT BINDING FEATURE s291 sa341 511
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Progesterone receptor
type: ProteinReference
xref: uniprot Q00175 148
organism: Mus musculus

STATE_TRANSITION_LEFT__PKCs-RIGHT__sa5_degraded-_re487
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re487 906
participant stoichiometry: PARTICIPANT STOICHIOMETRY re487 907
left: PKCs
interaction type: STATE_TRANSITION
right: sa5_degraded

UNKNOWN_TRANSITION_LEFT__IR-RIGHT__EGR1-_re286
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re286 589
participant stoichiometry: PARTICIPANT STOICHIOMETRY re286 590
left: IR
interaction type: UNKNOWN_TRANSITION
right: EGR1

Dnm1
type: ProteinReference
xref: P06781
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Dnm1
comment: ENTITY_REFERENCE_NOTES=GeneID: 13429
member entity reference: Dynamin-1

RICS
type: ProteinReference
xref: P06765
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.RICS
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Gene ID: 330914
member entity reference: Rho GTPase-activating protein 32

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q9Z1B7 87
organism: Mus musculus

Npr2
type: Protein
entity reference: Npr2
feature: COMPLEX PARTICIPANT BINDING FEATURE s436 sa451 269
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot Q9Z1B3 88
organism: Mus musculus

ATF2
type: ProteinReference
xref: P06732
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 11909
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.ATF2
member entity reference: Cyclic AMP-dependent transcription factor ATF-2

uniprot O70176 123
type: UnificationXref
id: O70176
db: uniprot

uniprot Q15583 72
type: UnificationXref
id: Q15583
db: uniprot

uniprot Q99N57 140
type: UnificationXref
id: Q99N57
db: uniprot

Inhba/b
type: Protein
entity reference: Inhba/b
feature: COMPLEX PARTICIPANT BINDING FEATURE s707 sa639 361
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

AdipoR1 R2 s185 sa131 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AdipoR1/R2
stoichiometric coefficient: 1.0

uniprot P47811 85
type: UnificationXref
id: P47811
db: uniprot

UNKNOWN_TRANSITION_LEFT__IR-RIGHT__EGR1-_re292
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re292 571
participant stoichiometry: PARTICIPANT STOICHIOMETRY re292 572
left: IR
interaction type: UNKNOWN_TRANSITION
right: EGR1

Activin receptor type-2B
type: ProteinReference
xref: PTHR23255:SF70
xref: uniprot P27040 180
organism: Mus musculus

STATE_TRANSITION_LEFT__AR-RIGHT__SF1-_re465
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re465 944
participant stoichiometry: PARTICIPANT STOICHIOMETRY re465 945
left: AR
interaction type: STATE_TRANSITION
right: SF1

PARTICIPANT STOICHIOMETRY re476 926
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__ERK1_2-RIGHT__5_QUOTE_SINGLE_FSHbeta-_re461
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re461 951
participant stoichiometry: PARTICIPANT STOICHIOMETRY re461 950
left: ERK1/2
interaction type: UNKNOWN_TRANSITION
right: 5' FSHbeta

Homeobox protein OTX1
type: ProteinReference
xref: uniprot P80205 98
organism: Mus musculus

uniprot P35375 144
type: UnificationXref
id: P35375
db: uniprot

Cyclic AMP-dependent transcription factor ATF-2
type: ProteinReference
xref: PTHR19304:SF9
xref: uniprot P16951 46
organism: Mus musculus

PA
type: SmallMolecule
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__PI3K-RIGHT__AKT-_re447
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re447 961
participant stoichiometry: PARTICIPANT STOICHIOMETRY re447 960
left: PI3K
interaction type: STATE_TRANSITION
right: AKT

STATE_TRANSITION_LEFT__SRC-RIGHT__SRC-_re341
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re341 552
participant stoichiometry: PARTICIPANT STOICHIOMETRY re341 551
left: SRC
interaction type: STATE_TRANSITION
right: SRC

CTNNB1
type: Protein
entity reference: CTNNB1
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re476 927
type: Stoichiometry
physical entity: Pyk2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PE-RIGHT__PKCs-_re488
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re488 902
participant stoichiometry: PARTICIPANT STOICHIOMETRY re488 903
left: PE
interaction type: STATE_TRANSITION
right: PKCs

STAT3
type: Protein
entity reference: STAT3
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

GnRHR
type: Protein
entity reference: GnRHR
feature: COMPLEX PARTICIPANT BINDING FEATURE s810 sa679 247
comment: SPECIES_TYPE=PROTEIN

Nuclear factor of activated T-cells, cytoplasmic 2
type: ProteinReference
xref: uniprot Q60591 106
organism: Mus musculus

TGIF1
type: Protein
entity reference: TGIF1
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

FSHbeta
type: RnaRegion
entity reference: FSHbeta
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

STATE_TRANSITION_LEFT__Ras-RIGHT__c_Raf-_re13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 836
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 837
left: Ras
interaction type: STATE_TRANSITION
right: c-Raf

GSK3
type: ProteinReference
xref: P06827
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 56637
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.GSK3
member entity reference: Glycogen synthase kinase-3 beta

uniprot O35607 120
type: UnificationXref
id: O35607
db: uniprot

uniprot O35099 153
type: UnificationXref
id: O35099
db: uniprot

TRANSCRIPTION_LEFT__CNP-RIGHT__CNP-_re455
type: TemplateReaction
product: CNP
xref: TRANSCRIPTION
participant: CNP
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

JAK1
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s640 sa569 399
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re324 580
type: Stoichiometry
physical entity: Follistatin
stoichiometric coefficient: 1.0

nPKCs
type: Protein
entity reference: nPKCs
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PKA
type: ProteinReference
xref: P06782
comment: ENTITY_REFERENCE_NOTES=Prkar1b: GeneID: 19085
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PKA
member entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P08752 210
xref: PTHR10218:SF73
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re652 645
type: Stoichiometry
physical entity: PITX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re652 646
type: Stoichiometry
physical entity: 3' FSHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re341 551
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re341 552
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

PACAP
type: Protein
entity reference: PACAP
feature: COMPLEX PARTICIPANT BINDING FEATURE s260 sa321 291
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR10728:SF13
type: RelationshipXref
id: PTHR10728:SF13
db: PANTHER Family
relationship type: By Homology

IRS-1
type: ProteinReference
xref: P06825
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= IRS-1: GeneID: 16367
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.IRS-1
member entity reference: Insulin receptor substrate 1

PARTICIPANT STOICHIOMETRY re642 670
type: Stoichiometry
physical entity: SF1
stoichiometric coefficient: 1.0

uniprot Q02956 28
type: UnificationXref
id: Q02956
db: uniprot

PARTICIPANT STOICHIOMETRY re642 671
type: Stoichiometry
physical entity: CTNNB1_SF1
stoichiometric coefficient: 1.0

Mothers against decapentaplegic homolog 2
type: ProteinReference
xref: PTHR13703:SF42
xref: uniprot Q62432 115
organism: Mus musculus

BMP2/4/15
type: Protein
entity reference: BMP2/4/15
feature: COMPLEX PARTICIPANT BINDING FEATURE s297 sa255 493
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot O08648 152
organism: Mus musculus

SNURF
type: ProteinReference
xref: P06808
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 84704
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.SNURF
member entity reference: Small nuclear ribonucleoprotein-associated protein N

AR
type: Protein
entity reference: AR
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

CTNNB1 s533 sa407 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CTNNB1
stoichiometric coefficient: 1.0

uniprot Q64727 34
type: UnificationXref
id: Q64727
db: uniprot

STATE_TRANSITION_LEFT__EGR1-RIGHT__5_QUOTE_SINGLE_LHbeta-_re628
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re628 721
participant stoichiometry: PARTICIPANT STOICHIOMETRY re628 720
left: EGR1
interaction type: STATE_TRANSITION
right: 5' LHbeta

Gbeta
type: ProteinReference
xref: P06769
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Gbeta
comment: ENTITY_REFERENCE_NOTES= Gnb1: GeneID: 14688; Gnb2: GeneID: 14693; Gnb3: GeneID: 14695; Gnb4: GeneID: 14696; Gnb5: GeneID: 14697
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Guanine nucleotide-binding protein subunit beta-5
member entity reference: Guanine nucleotide-binding protein subunit beta-4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

Isl 1 s643 sa572 tr1
type: BindingFeature
comment: MODIFICATION_REGION_SIZE=0.1
comment: MODIFICATION_REGION_ACTIVATION=FALSE
comment: MODIFICATION_REGION_POSITION=0.35000000000000003
comment: MODIFICATION_REGION_NAME=
comment: MODIFICATION_REGION_TYPE=RegulatoryRegion

SRC immune complex
type: Complex
component stoichiometry: Paxillin s853 sa523 STOICHIOMETRY ID COMPLEX
component stoichiometry: KSR 1 s857 sa527 STOICHIOMETRY ID COMPLEX
component stoichiometry: PKCs 3 s858 sa528 STOICHIOMETRY ID COMPLEX
component stoichiometry: MEK1 2 s859 sa529 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ras s861 sa531 STOICHIOMETRY ID COMPLEX
component stoichiometry: FAK s856 sa526 STOICHIOMETRY ID COMPLEX
component stoichiometry: Vinculin s854 sa524 STOICHIOMETRY ID COMPLEX
component stoichiometry: ERK1 2 s860 sa530 STOICHIOMETRY ID COMPLEX
component stoichiometry: GnRHR s863 sa519 STOICHIOMETRY ID COMPLEX
component stoichiometry: SRC s862 sa532 STOICHIOMETRY ID COMPLEX
component stoichiometry: Caveolin 1 s855 sa525 STOICHIOMETRY ID COMPLEX
component stoichiometry: Tubulin s852 sa522 STOICHIOMETRY ID COMPLEX
component: Ras
component: KSR-1
component: FAK
component: MEK1/2
component: PKCs(3)
component: Paxillin
component: GnRHR
component: ERK1/2
component: SRC
component: Caveolin-1
component: Vinculin
component: Tubulin
feature: COMPLEX BINDING FEATURE s512 csa20 314
feature: COMPLEX BINDING FEATURE s512 csa20 316
feature: COMPLEX BINDING FEATURE s512 csa20 324
feature: COMPLEX BINDING FEATURE s512 csa20 312
feature: COMPLEX BINDING FEATURE s512 csa20 306
feature: COMPLEX BINDING FEATURE s512 csa20 304
feature: COMPLEX BINDING FEATURE s512 csa20 326
feature: COMPLEX BINDING FEATURE s512 csa20 318
feature: COMPLEX BINDING FEATURE s512 csa20 308
feature: COMPLEX BINDING FEATURE s512 csa20 320
feature: COMPLEX BINDING FEATURE s512 csa20 310
feature: COMPLEX BINDING FEATURE s512 csa20 322
cellular location: Cytoplasm

UNKNOWN_TRANSITION_LEFT__Activin_A_homodimer-RIGHT__5_QUOTE_SINGLE_LHbeta-_re503
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re503 938
participant stoichiometry: PARTICIPANT STOICHIOMETRY re503 939
left: Activin A homodimer
interaction type: UNKNOWN_TRANSITION
right: 5' LHbeta

[GnRH_GnRHR]_gnas
type: Complex
component stoichiometry: gnas s536 sa34 STOICHIOMETRY ID COMPLEX
component stoichiometry: GnRH GnRHR s805 csa57 STOICHIOMETRY ID COMPLEX
component: GnRH_GnRHR
component: gnas
feature: COMPLEX BINDING FEATURE s808 csa54 252
feature: COMPLEX BINDING FEATURE s808 csa54 250
cellular location: Cytoplasm

uniprot O88444 207
type: UnificationXref
id: O88444
db: uniprot

PARTICIPANT STOICHIOMETRY re324 579
type: Stoichiometry
physical entity: JNK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re480 919
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re520 905
type: Stoichiometry
physical entity: PAC1R
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P47811 85
xref: PTHR24055:SF110
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re487 907
type: Stoichiometry
physical entity: sa5_degraded
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Pcaf_ER-RIGHT__Fosb-_re601
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re601 817
participant stoichiometry: PARTICIPANT STOICHIOMETRY re601 818
left: Pcaf_ER
interaction type: STATE_TRANSITION
right: Fosb

PARTICIPANT STOICHIOMETRY re213 790
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re487 906
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re520 904
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

GnRH_GnRHR
type: Complex
component stoichiometry: GnRHR s849 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: GnRH s850 sa256 STOICHIOMETRY ID COMPLEX
component: GnRHR
component: GnRH
feature: COMPLEX BINDING FEATURE s798 csa55 298
feature: COMPLEX BINDING FEATURE s798 csa55 296
cellular location: Cytoplasm

PLA2
type: ProteinReference
xref: P06738
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Pla2g4a: GeneID: 18783; Pla2g6: GeneID: 53357; Pla2g4c: GeneID: 232889
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PLA2
member entity reference: 85/88 kDa calcium-independent phospholipase A2
member entity reference: Cytosolic phospholipase A2
member entity reference: Cytosolic phospholipase A2 gamma

PARTICIPANT STOICHIOMETRY re480 918
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re642 669
type: Stoichiometry
physical entity: CTNNB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re607 807
type: Stoichiometry
physical entity: ELK1_SRF
stoichiometric coefficient: 1.0

Nur77_TORC1
type: Complex
component stoichiometry: Nur77 s745 sa667 STOICHIOMETRY ID COMPLEX
component stoichiometry: TORC1 s744 sa668 STOICHIOMETRY ID COMPLEX
component: Nur77
component: TORC1
feature: COMPLEX BINDING FEATURE s759 csa32 520
feature: COMPLEX BINDING FEATURE s759 csa32 522
cellular location: Nucleus

PARTICIPANT STOICHIOMETRY re586 748
type: Stoichiometry
physical entity: CBP
stoichiometric coefficient: 1.0

go GO:0005783 3
type: UnificationXref
id: GO:0005783
db: go

STATE_TRANSITION_LEFT__PR-RIGHT__5_QUOTE_SINGLE_FSHbeta-_re650
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re650 647
participant stoichiometry: PARTICIPANT STOICHIOMETRY re650 648
left: PR
interaction type: STATE_TRANSITION
right: 5' FSHbeta

PARTICIPANT STOICHIOMETRY re586 749
type: Stoichiometry
physical entity: CBP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re661 613
type: Stoichiometry
physical entity: GnRH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re661 614
type: Stoichiometry
physical entity: GnRH_SRC immune complex
stoichiometric coefficient: 1.0

Transforming growth factor beta-2 proprotein
type: ProteinReference
xref: PTHR11848:SF141
xref: uniprot P27090 48
organism: Mus musculus

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot P47809 170
xref: PTHR48013:SF15
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re607 808
type: Stoichiometry
physical entity: c-fos
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re217 781
type: Stoichiometry
physical entity: 5' FSHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re217 780
type: Stoichiometry
physical entity: BMPR-IA/IB/II
stoichiometric coefficient: 1.0

TGFbeta
type: ProteinReference
xref: P06778
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=TGF-beta1: GeneID: 21803 ; TGF-beta2: GeneID: 21808
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.TGFbeta
member entity reference: Transforming growth factor beta-1 proprotein
member entity reference: Transforming growth factor beta-2 proprotein

ELK1
type: Protein
entity reference: ELK1
feature: COMPLEX PARTICIPANT BINDING FEATURE s678 sa611 483
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re661 612
type: Stoichiometry
physical entity: SRC immune complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re428 987
type: Stoichiometry
physical entity: GC
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__AR-RIGHT__3_QUOTE_SINGLE_FSHbeta-_re653
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re653 643
participant stoichiometry: PARTICIPANT STOICHIOMETRY re653 644
left: AR
interaction type: STATE_TRANSITION
right: 3' FSHbeta

PARTICIPANT STOICHIOMETRY re428 986
type: Stoichiometry
physical entity: Npr2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re555 846
type: Stoichiometry
physical entity: MEK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re555 847
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PKA-RIGHT__CREB-_re490
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re490 890
participant stoichiometry: PARTICIPANT STOICHIOMETRY re490 891
left: PKA
interaction type: STATE_TRANSITION
right: CREB

PARTICIPANT STOICHIOMETRY re614 767
type: Stoichiometry
physical entity: PACAP
stoichiometric coefficient: 1.0

gnai
type: ProteinReference
xref: P06807
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.gnai
comment: ENTITY_REFERENCE_NOTES= Gnai1: GeneID: 14677; Gnai2: GeneID: 14678; Gnai3: GeneID: 14679
member entity reference: Guanine nucleotide-binding protein G(k) subunit alpha
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-2

Prostaglandin E2 receptor EP4 subtype
type: ProteinReference
xref: uniprot P32240 143
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re614 766
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CBP-RIGHT__EGR1-_re587
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re587 745
participant stoichiometry: PARTICIPANT STOICHIOMETRY re587 744
left: CBP
interaction type: STATE_TRANSITION
right: EGR1

uniprot O89090 206
type: UnificationXref
id: O89090
db: uniprot

PARTICIPANT STOICHIOMETRY re657 636
type: Stoichiometry
physical entity: 3' FSHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re657 635
type: Stoichiometry
physical entity: CREB_TORC1
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__MISRII-RIGHT__3_QUOTE_SINGLE_LHbeta-_re204
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re204 826
participant stoichiometry: PARTICIPANT STOICHIOMETRY re204 825
left: MISRII
interaction type: UNKNOWN_TRANSITION
right: 3' LHbeta

L-type Ca2+
type: Protein
entity reference: L-type Ca2+
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re213 789
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

mPer1
type: RnaRegion
entity reference: mPer1
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

Pcaf
type: ProteinReference
xref: P06715
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Pcaf
comment: ENTITY_REFERENCE_NOTES= GeneID: 18519
member entity reference: Histone acetyltransferase KAT2B

PKCs(3)
type: Protein
entity reference: PKCs(3)
feature: COMPLEX PARTICIPANT BINDING FEATURE s873 sa702 467
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Ca2+
type: SmallMolecule
cellular location: Endoplasmic Reticulum
comment: SPECIES_TYPE=ION

PARTICIPANT STOICHIOMETRY re542 867
type: Stoichiometry
physical entity: AK006051
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re542 866
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PKCs-RIGHT__MT1_MMP-_re395
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re395 976
participant stoichiometry: PARTICIPANT STOICHIOMETRY re395 977
left: PKCs
interaction type: STATE_TRANSITION
right: MT1-MMP

RICS
type: DnaRegion
entity reference: RICS
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

AdipoR1/R2
type: Protein
entity reference: AdipoR1/R2
feature: COMPLEX PARTICIPANT BINDING FEATURE s185 sa131 517
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

CNP_Npr2
type: Complex
component stoichiometry: Npr2 s436 sa451 STOICHIOMETRY ID COMPLEX
component stoichiometry: CNP s434 sa450 STOICHIOMETRY ID COMPLEX
component: CNP
component: Npr2
feature: COMPLEX BINDING FEATURE s763 csa34 268
feature: COMPLEX BINDING FEATURE s763 csa34 266
cellular location: Cytoplasm

PARTICIPANT STOICHIOMETRY re636 685
type: Stoichiometry
physical entity: SMAD_PITX_OTX
stoichiometric coefficient: 1.0

uniprot Q9R078 221
type: UnificationXref
id: Q9R078
db: uniprot

Inha s706 sa638 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Inha
stoichiometric coefficient: 1.0

uniprot Q91WG5 220
type: UnificationXref
id: Q91WG5
db: uniprot

PARTICIPANT STOICHIOMETRY re636 686
type: Stoichiometry
physical entity: 3' LHbeta
stoichiometric coefficient: 1.0

Ras
type: Protein
entity reference: Ras
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

LHbeta
type: Protein
entity reference: LHbeta
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re301 621
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re301 622
type: Stoichiometry
physical entity: AKT
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ATF2-RIGHT__CGA-_re646
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re646 662
participant stoichiometry: PARTICIPANT STOICHIOMETRY re646 661
left: ATF2
interaction type: STATE_TRANSITION
right: CGA

Cytosolic phospholipase A2 gamma
type: ProteinReference
xref: uniprot Q64GA5 233
organism: Mus musculus

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__gnas-RIGHT__AC-_re42
control type: INHIBITION
controller: gnai

UNKNOWN_TRANSITION_LEFT__IR-RIGHT__ERK1_2-_re431
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re431 971
participant stoichiometry: PARTICIPANT STOICHIOMETRY re431 970
left: IR
interaction type: UNKNOWN_TRANSITION
right: ERK1/2

PTHR45627:SF12
type: RelationshipXref
id: PTHR45627:SF12
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re456 955
type: Stoichiometry
physical entity: CNP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re124 912
type: Stoichiometry
physical entity: PLA2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re456 954
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re124 913
type: Stoichiometry
physical entity: AA
stoichiometric coefficient: 1.0

ActRII
type: Protein
entity reference: ActRII
feature: COMPLEX PARTICIPANT BINDING FEATURE s688 sa618 403
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__CREB-RIGHT__NOSI-_re498
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re498 872
participant stoichiometry: PARTICIPANT STOICHIOMETRY re498 873
left: CREB
interaction type: STATE_TRANSITION
right: NOSI

uniprot Q62432 115
type: UnificationXref
id: Q62432
db: uniprot

PTHR12533:SF11
type: RelationshipXref
id: PTHR12533:SF11
db: PANTHER Family
relationship type: By Homology

SRC s877 sa706 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

uniprot P47931 8
type: UnificationXref
id: P47931
db: uniprot

PARTICIPANT STOICHIOMETRY re615 765
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re615 764
type: Stoichiometry
physical entity: AR
stoichiometric coefficient: 1.0

Transcription factor jun-B
type: ProteinReference
xref: uniprot P09450 228
xref: PTHR11462:SF37
organism: Mus musculus

uniprot Q64318 186
type: UnificationXref
id: Q64318
db: uniprot

TRANSCRIPTION_LEFT__RICS-RIGHT__RICS-_re534
type: TemplateReaction
product: RICS
xref: TRANSCRIPTION
participant: RICS
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

GSK3
type: Protein
entity reference: GSK3
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Transcription factor jun-D
type: ProteinReference
xref: uniprot P15066 240
xref: PTHR11462:SF7
organism: Mus musculus

uniprot O54950 216
type: UnificationXref
id: O54950
db: uniprot

GnRH s879 sa709 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GnRH
stoichiometric coefficient: 1.0

PI3K
type: ProteinReference
xref: P06766
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 18708
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PI3K
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha

GDP s670 sa602 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re609 805
type: Stoichiometry
physical entity: SRF
stoichiometric coefficient: 1.0

Adiponectin_AdipoR1/R2
type: Complex
component stoichiometry: Adiponectin s202 sa260 STOICHIOMETRY ID COMPLEX
component stoichiometry: AdipoR1 R2 s185 sa131 STOICHIOMETRY ID COMPLEX
component: AdipoR1/R2
component: Adiponectin
feature: COMPLEX BINDING FEATURE s775 csa44 516
feature: COMPLEX BINDING FEATURE s775 csa44 518
cellular location: Cytoplasm

miR-132/212
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.miR-132/212
comment: ENTITY_REFERENCE_NOTES=Mir132: GeneID: 387150; Mir212: GeneID: 387208

PLD
type: Protein
entity reference: PLD
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__CREB_TORC1-RIGHT__3_QUOTE_SINGLE_FSHbeta-_re657
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re657 636
participant stoichiometry: PARTICIPANT STOICHIOMETRY re657 635
left: CREB_TORC1
interaction type: STATE_TRANSITION
right: 3' FSHbeta

PARTICIPANT STOICHIOMETRY re609 806
type: Stoichiometry
physical entity: c-fos
stoichiometric coefficient: 1.0

Scg2
type: DnaRegionReference
member entity reference: Secretogranin-2
xref: G06880
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.Scg2
comment: ENTITY_REFERENCE_NOTES=Gene ID: 20254

Voltage-dependent L-type calcium channel subunit alpha-1F
type: ProteinReference
xref: PTHR45628:SF2
xref: uniprot Q9JIS7 59
organism: Mus musculus

Atf3
type: RnaRegionReference
comment: ENTITY_REFERENCE_NOTES=GeneID: 11910
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.Atf3

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__DAG-RIGHT__PA-_re340
controller: SRC_DGK-zeta

uniprot P70662 174
type: UnificationXref
id: P70662
db: uniprot

SF1
type: Protein
entity reference: SF1
feature: COMPLEX PARTICIPANT BINDING FEATURE s832 sa689 443
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re364 531
type: Stoichiometry
physical entity: PE
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__TORC1-RIGHT__CGA-_re589
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re589 734
participant stoichiometry: PARTICIPANT STOICHIOMETRY re589 735
left: TORC1
interaction type: UNKNOWN_TRANSITION
right: CGA

INHIBITION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re364 530
type: Stoichiometry
physical entity: PLD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re364 532
type: Stoichiometry
physical entity: PA
stoichiometric coefficient: 1.0

Transcription factor 7-like 1
type: ProteinReference
xref: PTHR10373:SF25
xref: uniprot Q9Z1J1 71
organism: Mus musculus

STATE_TRANSITION_LEFT__gnas-RIGHT__AC-_re42
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 717
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 716
left: gnas
interaction type: STATE_TRANSITION
right: AC

Ras-related protein Rap-1b
type: ProteinReference
xref: PTHR24070:SF393
xref: uniprot Q99JI6 50
organism: Mus musculus

uniprot Q61161 18
type: UnificationXref
id: Q61161
db: uniprot

GnRH GnRHR s809 csa58 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GnRH_GnRHR
stoichiometric coefficient: 1.0

uniprot P61372 41
type: UnificationXref
id: P61372
db: uniprot

PARTICIPANT STOICHIOMETRY re393 980
type: Stoichiometry
physical entity: SNURF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re393 981
type: Stoichiometry
physical entity: SP1
stoichiometric coefficient: 1.0

SRF
type: Protein
entity reference: SRF
feature: COMPLEX PARTICIPANT BINDING FEATURE s676 sa609 481
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

CBP
type: Protein
entity reference: CBP
feature: CBP s740 sa662 rs1
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PKCs-RIGHT__PR-_re445
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re445 965
participant stoichiometry: PARTICIPANT STOICHIOMETRY re445 964
left: PKCs
interaction type: STATE_TRANSITION
right: PR

STATE_TRANSITION_LEFT__CTNNB1_TCF-RIGHT__Junc-_re599
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re599 696
participant stoichiometry: PARTICIPANT STOICHIOMETRY re599 695
left: CTNNB1_TCF
interaction type: STATE_TRANSITION
right: Junc

uniprot P04202 47
type: UnificationXref
id: P04202
db: uniprot

PARTICIPANT STOICHIOMETRY re604 813
type: Stoichiometry
physical entity: p65_p65
stoichiometric coefficient: 1.0

miR-132/212
type: RnaRegion
entity reference: miR-132/212
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__Zeb1-RIGHT__Zeb1-_re290
control type: INHIBITION
controller: ER

PARTICIPANT STOICHIOMETRY re631 694
type: Stoichiometry
physical entity: 5' LHbeta
stoichiometric coefficient: 1.0

PTHR11509:SF0
type: RelationshipXref
id: PTHR11509:SF0
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re604 814
type: Stoichiometry
physical entity: COX2
stoichiometric coefficient: 1.0

uniprot Q6VVW5 45
type: UnificationXref
id: Q6VVW5
db: uniprot

Inhba s720 sa644 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Inhba
stoichiometric coefficient: 2.0

Insulin receptor substrate 3, isoform CRA_a (Fragment)
type: ProteinReference
xref: uniprot O54718 181
xref: PTHR10614:SF8
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re390 983
type: Stoichiometry
physical entity: 5' LHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re390 982
type: Stoichiometry
physical entity: Ca/CaMK II
stoichiometric coefficient: 1.0

5 HT3AR s124 sa178 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 5-HT3AR
stoichiometric coefficient: 1.0

PGs_PG Rcs
type: Complex
component stoichiometry: PG Rcs s630 sa561 STOICHIOMETRY ID COMPLEX
component stoichiometry: PGs s629 sa562 STOICHIOMETRY ID COMPLEX
component: PG Rcs
component: PGs
feature: COMPLEX BINDING FEATURE s774 csa43 286
feature: COMPLEX BINDING FEATURE s774 csa43 288
cellular location: Cytoplasm

Activin A homodimer
type: Complex
component stoichiometry: Inhba s713 sa642 STOICHIOMETRY ID COMPLEX
component: Inhba
feature: COMPLEX BINDING FEATURE s712 csa26 514

Pyk2
type: Protein
entity reference: Pyk2
feature: COMPLEX PARTICIPANT BINDING FEATURE s494 sa512 407
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR48016:SF31
type: RelationshipXref
id: PTHR48016:SF31
db: PANTHER Family
relationship type: By Homology

PTHR48016:SF32
type: RelationshipXref
id: PTHR48016:SF32
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__ERK1_2-RIGHT__EGR1-_re275
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re275 609
participant stoichiometry: PARTICIPANT STOICHIOMETRY re275 608
left: ERK1/2
interaction type: STATE_TRANSITION
right: EGR1

uniprot P23204 95
type: UnificationXref
id: P23204
db: uniprot

PARTICIPANT STOICHIOMETRY re631 693
type: Stoichiometry
physical entity: SF1
stoichiometric coefficient: 1.0

EIF2A
type: ProteinReference
xref: P06762
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 229317
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.EIF2A
member entity reference: Eukaryotic translation initiation factor 2A

Vesicular secretion
type: Pathway

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__3_QUOTE_SINGLE_FSHbeta-RIGHT__FSHbeta-_re514
control type: INHIBITION
controller: TGIF1

TCF s74 sa406 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCF
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__GnRHR-RIGHT__PLA2-_re261
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re261 630
participant stoichiometry: PARTICIPANT STOICHIOMETRY re261 629
left: GnRHR
interaction type: UNKNOWN_TRANSITION
right: PLA2

uniprot Q1HKZ5 157
type: UnificationXref
id: Q1HKZ5
db: uniprot

TRANSPORT_LEFT__PGs-RIGHT__PGs-_re518
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re518 921
participant stoichiometry: PARTICIPANT STOICHIOMETRY re518 920
left: PGs
interaction type: TRANSPORT
right: PGs

uniprot Q60591 106
type: UnificationXref
id: Q60591
db: uniprot

Mothers against decapentaplegic homolog 9
type: ProteinReference
xref: PTHR13703:SF41
xref: uniprot Q9JIW5 117
organism: Mus musculus

uniprot O88393 177
type: UnificationXref
id: O88393
db: uniprot

PARTICIPANT STOICHIOMETRY re583 757
type: Stoichiometry
physical entity: CGA
stoichiometric coefficient: 1.0

BMPR-IA/IB/II
type: Protein
entity reference: BMPR-IA/IB/II
feature: COMPLEX PARTICIPANT BINDING FEATURE s191 sa213 491
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

EGR1
type: RnaRegion
entity reference: EGR1
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

gnas
type: Protein
entity reference: gnas
feature: COMPLEX PARTICIPANT BINDING FEATURE s536 sa34 253
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re583 756
type: Stoichiometry
physical entity: NFAT
stoichiometric coefficient: 1.0

Pbx1 s140 sa200 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pbx1
stoichiometric coefficient: 1.0

uniprot P12757 82
type: UnificationXref
id: P12757
db: uniprot

Csda s698 sa630 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Csda
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__DAG-RIGHT__PKCs-_re20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 799
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 800
left: DAG
interaction type: STATE_TRANSITION
right: PKCs

uniprot P68373 132
type: UnificationXref
id: P68373
db: uniprot

PTHR10614:SF11
type: RelationshipXref
id: PTHR10614:SF11
db: PANTHER Family
relationship type: By Homology

IGF-1R
type: ProteinReference
xref: P06703
comment: ENTITY_REFERENCE_NOTES= GeneID: 16001
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.IGF-1R
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Insulin-like growth factor 1 receptor

PTHR24216:SF11
type: RelationshipXref
id: PTHR24216:SF11
db: PANTHER Family
relationship type: By Homology

UNKNOWN_TRANSITION_LEFT__Alk4_ActivinA_ActRII_IIB-RIGHT__GnRHR-_re209
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re209 820
participant stoichiometry: PARTICIPANT STOICHIOMETRY re209 819
left: Alk4_ActivinA_ActRII/IIB
interaction type: UNKNOWN_TRANSITION
right: GnRHR

Ras-related protein Rap-1b
type: DnaReference
xref: PTHR24070:SF393
organism: Mus musculus

OCT-1
type: ProteinReference
xref: P06720
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.OCT-1
comment: ENTITY_REFERENCE_NOTES=GeneID: 18986 PMID: 15388790 It is shown that OCT-1 binds to SURG-1 element of GnRH receptor promoter. By GnRH exposure, OCT-1 binding to GnRH receptor promoter is increased. PMID: 19333792 This study suggests that the two most proximal homeodomain-binding sites (Hbox1 and Hbox2) in the murine GnRHR promoter may regulate the promoter in a developmentally dependent fashion and that Oct-1 acts at multiple but distinct TAAT sites to support basal transcription. The Hbox1 region displayed specific binding to homeoprotein Oct-1.
member entity reference: POU domain, class 2, transcription factor 1

TRANSCRIPTION_LEFT__Glut1-RIGHT__Glut1-_re564
type: TemplateReaction
product: Glut1
xref: TRANSCRIPTION
participant: Glut1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

STATE_TRANSITION_LEFT__CREB-RIGHT__GnRHR-_re623
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re623 731
participant stoichiometry: PARTICIPANT STOICHIOMETRY re623 730
left: CREB
interaction type: STATE_TRANSITION
right: GnRHR

Activin receptor type-1B
type: ProteinReference
xref: PTHR23255:SF22
xref: uniprot Q61271 241
organism: Mus musculus

Zeb1
type: RnaRegionReference
comment: ENTITY_REFERENCE_NOTES=GeneID: 21417
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.Zeb1

ACTIVE 226
type: EntityFeature
comment: Active state

STATE_TRANSITION_LEFT__SF1-RIGHT__CGA-_re644
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re644 666
participant stoichiometry: PARTICIPANT STOICHIOMETRY re644 665
left: SF1
interaction type: STATE_TRANSITION
right: CGA

PARTICIPANT STOICHIOMETRY re323 582
type: Stoichiometry
physical entity: Follistatin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re323 581
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

Prolactin
type: ProteinReference
xref: uniprot P06879 38
organism: Mus musculus

GnRHR
type: Protein
entity reference: GnRHR
feature: COMPLEX PARTICIPANT BINDING FEATURE s803 sa681 255
comment: SPECIES_TYPE=PROTEIN

Serotonin
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s198 sa257 429
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__OCT_1-RIGHT__GnRHR-_re617
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re617 761
participant stoichiometry: PARTICIPANT STOICHIOMETRY re617 760
left: OCT-1
interaction type: STATE_TRANSITION
right: GnRHR

CBP s741 sa661 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.39269908169872414

MKK3/6
type: Protein
entity reference: MKK3/6
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot Q63932 43
organism: Mus musculus

UNKNOWN_TRANSITION_LEFT__GnRH_GnRHR-RIGHT__Rap1b-_re570
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re570 795
participant stoichiometry: PARTICIPANT STOICHIOMETRY re570 796
left: GnRH_GnRHR
interaction type: UNKNOWN_TRANSITION
right: Rap1b

uniprot Q60700 159
type: UnificationXref
id: Q60700
db: uniprot

UNKNOWN_TRANSITION_LEFT__MISRII-RIGHT__5_QUOTE_SINGLE_FSHbeta-_re205
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re205 823
participant stoichiometry: PARTICIPANT STOICHIOMETRY re205 824
left: MISRII
interaction type: UNKNOWN_TRANSITION
right: 5' FSHbeta

BMP6/7_ActRII
type: Complex
component stoichiometry: ActRII s688 sa618 STOICHIOMETRY ID COMPLEX
component stoichiometry: BMP6 7 s687 sa617 STOICHIOMETRY ID COMPLEX
component: ActRII
component: BMP6/7
feature: COMPLEX BINDING FEATURE s764 csa35 400
feature: COMPLEX BINDING FEATURE s764 csa35 402
cellular location: Cytoplasm

PARTICIPANT STOICHIOMETRY re627 722
type: Stoichiometry
physical entity: Isl-1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__SP1_SP3-RIGHT__CNP-_re600
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re600 822
participant stoichiometry: PARTICIPANT STOICHIOMETRY re600 821
left: SP1_SP3
interaction type: STATE_TRANSITION
right: CNP

GnRHR s849 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

uniprot P21279 102
type: UnificationXref
id: P21279
db: uniprot

PARTICIPANT STOICHIOMETRY re627 723
type: Stoichiometry
physical entity: 5' LHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re624 728
type: Stoichiometry
physical entity: MASH1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re624 729
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PLA2-RIGHT__AA-_re124
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re124 913
participant stoichiometry: PARTICIPANT STOICHIOMETRY re124 912
left: PLA2
interaction type: STATE_TRANSITION
right: AA

uniprot P70340 112
type: UnificationXref
id: P70340
db: uniprot

PARTICIPANT STOICHIOMETRY re606 810
type: Stoichiometry
physical entity: Zeb1
stoichiometric coefficient: 1.0

Paired mesoderm homeobox protein 2
type: ProteinReference
xref: uniprot Q06348 33
organism: Mus musculus

5'-AMP-activated protein kinase subunit gamma-1
type: ProteinReference
xref: uniprot O54950 216
organism: Mus musculus

NAB
type: ProteinReference
xref: P06801
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.NAB
comment: ENTITY_REFERENCE_NOTES=Nab1: GeneID: 17936; Nab2: GeneID: 17937 PMID: 17299135 NAB1/2 is shown to inhibit EGR1 acting on LHb promoter lowering LHb inducibility.
member entity reference: NGFI-A-binding protein 2
member entity reference: NGFI-A-binding protein 1

5-HT3AR
type: ProteinReference
xref: P06833
comment: ENTITY_REFERENCE_NOTES= GeneID: 15561
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.5-HT3AR
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: 5-hydroxytryptamine receptor 3A

Alk4
type: ProteinReference
xref: P06845
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.Alk4
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
comment: ENTITY_REFERENCE_NOTES=GeneID: 11479
member entity reference: Activin receptor type-1B

PARTICIPANT STOICHIOMETRY re620 742
type: Stoichiometry
physical entity: OCT-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re620 743
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re606 809
type: Stoichiometry
physical entity: ER
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__OCT_1-RIGHT__GnRHR-_re620
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re620 742
participant stoichiometry: PARTICIPANT STOICHIOMETRY re620 743
left: OCT-1
interaction type: STATE_TRANSITION
right: GnRHR

ERK1/2
type: Protein
entity reference: ERK1/2
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

IRS
type: Protein
entity reference: IRS
feature: COMPLEX PARTICIPANT BINDING FEATURE s470 sa483 489
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

IRS
type: ProteinReference
xref: P06759
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.IRS
comment: ENTITY_REFERENCE_NOTES= IRS-1: GeneID: 16367; IRS-2: GeneID: 384783; IRS-3: GeneID: 16369; IRS-4: GeneID: 16370
member entity reference: Insulin receptor substrate 4
member entity reference: Insulin receptor substrate 1
member entity reference: Insulin receptor substrate 2
member entity reference: Insulin receptor substrate 3, isoform CRA_a (Fragment)

PARTICIPANT STOICHIOMETRY re4 529
type: Stoichiometry
physical entity: MEK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 528
type: Stoichiometry
physical entity: c-Raf
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NF_Y-RIGHT__GnRHR-_re616
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re616 763
participant stoichiometry: PARTICIPANT STOICHIOMETRY re616 762
left: NF-Y
interaction type: STATE_TRANSITION
right: GnRHR

PARTICIPANT STOICHIOMETRY re225 752
type: Stoichiometry
physical entity: Alk4_ActivinA_ActRII/IIB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re225 753
type: Stoichiometry
physical entity: TAK1
stoichiometric coefficient: 1.0

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot Q02956 28
organism: Mus musculus

STATE_TRANSITION_LEFT__Caln-RIGHT__NFAT-_re582
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re582 759
participant stoichiometry: PARTICIPANT STOICHIOMETRY re582 758
left: Caln
interaction type: STATE_TRANSITION
right: NFAT

Nuclear transcription factor Y subunit alpha
type: ProteinReference
xref: uniprot P23708 9
organism: Mus musculus

PEA 15 s653 sa584 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

uniprot P29387 191
type: UnificationXref
id: P29387
db: uniprot

Transcription factor Sp1
type: ProteinReference
xref: uniprot O89090 206
organism: Mus musculus

HETERODIMER_ASSOCIATION_LEFT__Csda-_EGR1-RIGHT__EGR1_Csda-_re562
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re562 833
participant stoichiometry: PARTICIPANT STOICHIOMETRY re562 832
participant stoichiometry: PARTICIPANT STOICHIOMETRY re562 831
left: Csda
left: EGR1
interaction type: HETERODIMER_ASSOCIATION
right: EGR1_Csda

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot Q9Z329 94
xref: PTHR13715:SF53
organism: Mus musculus

PTHR18945:SF52
type: RelationshipXref
id: PTHR18945:SF52
db: PANTHER Family
relationship type: By Homology

JNK1/2
type: ProteinReference
xref: P06847
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.JNK1/2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=JNK1: GeneID: 26419; JNK2: GeneID: 26420
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Mitogen-activated protein kinase 9

PARTICIPANT STOICHIOMETRY re13 836
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

Annexin A5
type: Protein
entity reference: Annexin A5
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re13 837
type: Stoichiometry
physical entity: c-Raf
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PKA-RIGHT__SF1-_re157
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re157 857
participant stoichiometry: PARTICIPANT STOICHIOMETRY re157 856
left: PKA
interaction type: STATE_TRANSITION
right: SF1

uniprot Q01279 165
type: UnificationXref
id: Q01279
db: uniprot

uniprot Q02384 36
type: UnificationXref
id: Q02384
db: uniprot

TRANSCRIPTION_LEFT__Isl_1-RIGHT__Isl_1-_re523
type: TemplateReaction
product: Isl-1
xref: TRANSCRIPTION
participant: Isl-1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Pituitary adenylate cyclase-activating polypeptide
type: ProteinReference
xref: uniprot O70176 123
organism: Mus musculus

SF1
type: Protein
entity reference: SF1
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PTHR24361:SF414
type: RelationshipXref
id: PTHR24361:SF414
db: PANTHER Family
relationship type: By Homology

Junc
type: DnaRegionReference
member entity reference: Transcription factor AP-1
xref: G06891
comment: ENTITY_REFERENCE_NOTES=GeneID: 16476
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.Junc

PTHR48019:SF40
type: RelationshipXref
id: PTHR48019:SF40
db: PANTHER Family
relationship type: By Homology

uniprot P16054 24
type: UnificationXref
id: P16054
db: uniprot

PTHR10218:SF227
type: RelationshipXref
id: PTHR10218:SF227
db: PANTHER Family
relationship type: By Homology

uniprot P06537 68
type: UnificationXref
id: P06537
db: uniprot

PARTICIPANT STOICHIOMETRY re550 855
type: Stoichiometry
physical entity: TGIF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re550 854
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NOSI-RIGHT__NO-_re346
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re346 545
participant stoichiometry: PARTICIPANT STOICHIOMETRY re346 546
left: NOSI
interaction type: STATE_TRANSITION
right: NO

TRANSLATION
type: RelationshipTypeVocabulary

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot P63328 199
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re44 713
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

Annexin A5
type: ProteinReference
xref: P06814
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Annexin A5
comment: ENTITY_REFERENCE_NOTES=GeneID: 11747
member entity reference: Annexin A5

PARTICIPANT STOICHIOMETRY re467 942
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

gnai
type: Protein
entity reference: gnai
feature: COMPLEX PARTICIPANT BINDING FEATURE s735 sa654 343
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot O70362 176
type: UnificationXref
id: O70362
db: uniprot

PG Rcs
type: ProteinReference
xref: P06836
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.PG Rcs
comment: ENTITY_REFERENCE_NOTES= EP1: GeneID: 19216; EP2: GeneID: 19217; EP3: GeneID: 19218; EP4: GeneID: 19219; FP: GeneID: 19220; IP: GeneID: 19222
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Prostaglandin E2 receptor EP2 subtype
member entity reference: Prostaglandin F2-alpha receptor
member entity reference: Prostacyclin receptor
member entity reference: Prostaglandin E2 receptor EP3 subtype
member entity reference: Prostaglandin E2 receptor EP1 subtype
member entity reference: Prostaglandin E2 receptor EP4 subtype

STATE_TRANSITION_LEFT__SMAD2_4-RIGHT__SMAD2_4-_re332
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re332 566
participant stoichiometry: PARTICIPANT STOICHIOMETRY re332 565
left: SMAD2-4
interaction type: STATE_TRANSITION
right: SMAD2-4

C-type natriuretic peptide
type: ProteinReference
xref: uniprot Q61839 6
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re467 943
type: Stoichiometry
physical entity: EGR1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__EIF2AK3-RIGHT__EIF2AK3-_re265
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re265 626
participant stoichiometry: PARTICIPANT STOICHIOMETRY re265 625
left: EIF2AK3
interaction type: STATE_TRANSITION
right: EIF2AK3

FOS s150 sa203 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__NF_Y_JUN_FOS-RIGHT__5_QUOTE_SINGLE_FSHbeta-_re648
control type: INHIBITION
controller: Gbeta_Ggamma

EGR1
type: DnaRegionReference
member entity reference: Early growth response protein 1
xref: G06887
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.EGR1
comment: ENTITY_REFERENCE_NOTES=GeneID: 13653

EGR1
type: Protein
entity reference: EGR1
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

GnRHR
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.GnRHR
comment: ENTITY_REFERENCE_NOTES=GeneID: 14715

PTHR10218:SF230
type: RelationshipXref
id: PTHR10218:SF230
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__SMAD2_4-RIGHT__SMAD2_4-_re334
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re334 564
participant stoichiometry: PARTICIPANT STOICHIOMETRY re334 563
left: SMAD2-4
interaction type: STATE_TRANSITION
right: SMAD2-4

uniprot P28652 202
type: UnificationXref
id: P28652
db: uniprot

Inhba
type: Protein
entity reference: Inhba
feature: COMPLEX PARTICIPANT BINDING FEATURE s720 sa644 421
comment: SPECIES_TYPE=PROTEIN

Ras
type: Protein
entity reference: Ras
feature: COMPLEX PARTICIPANT BINDING FEATURE s861 sa531 325
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re44 712
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

PTHR46180:SF1
type: RelationshipXref
id: PTHR46180:SF1
db: PANTHER Family
relationship type: By Homology

uniprot P05017 237
type: UnificationXref
id: P05017
db: uniprot

MAP2K1/2
type: Protein
entity reference: MAP2K1/2
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q9Z0L4 215
type: UnificationXref
id: Q9Z0L4
db: uniprot

Tubulin s852 sa522 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Tubulin
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit alpha-1C
type: ProteinReference
xref: uniprot Q01815 56
xref: PTHR45628:SF10
organism: Mus musculus

Leptin
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s639 sa568 397
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re336 560
type: Stoichiometry
physical entity: 12-LO
stoichiometric coefficient: 1.0

Pro-FMRFamide-related neuropeptide VF
type: ProteinReference
xref: uniprot Q9ESQ8 224
organism: Mus musculus

STATE_TRANSITION_LEFT__PKA-RIGHT__5_QUOTE_SINGLE_LHbeta-_re418
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re418 1003
participant stoichiometry: PARTICIPANT STOICHIOMETRY re418 1002
left: PKA
interaction type: STATE_TRANSITION
right: 5' LHbeta

ERK1 2 s860 sa530 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NF_Y_JUN_FOS-RIGHT__5_QUOTE_SINGLE_FSHbeta-_re648
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re648 658
participant stoichiometry: PARTICIPANT STOICHIOMETRY re648 657
left: NF-Y_JUN_FOS
interaction type: STATE_TRANSITION
right: 5' FSHbeta

UNKNOWN_TRANSITION
type: Control
xref: UNKNOWN TRANSITION
controlled: Cap-dependent translation
controller: ERK1/2

JNK1/2
type: Protein
entity reference: JNK1/2
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

EIF2A
type: Protein
entity reference: EIF2A
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s670 sa602 285
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ras
type: Protein
entity reference: Ras
feature: COMPLEX PARTICIPANT BINDING FEATURE s876 sa705 473
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Junc
type: ProteinReference
xref: P06710
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 16476
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Junc
member entity reference: Transcription factor AP-1

LIM domain-binding protein 1
type: ProteinReference
xref: uniprot P70662 174
organism: Mus musculus

STATE_TRANSITION_LEFT__ELK1_SRF-RIGHT__c_fos-_re607
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re607 808
participant stoichiometry: PARTICIPANT STOICHIOMETRY re607 807
left: ELK1_SRF
interaction type: STATE_TRANSITION
right: c-fos

SP1 s818 sa499 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re592 706
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re592 705
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PTHR24416:SF91
type: RelationshipXref
id: PTHR24416:SF91
db: PANTHER Family
relationship type: By Homology

P06859
type: UnificationXref
id: P06859
db: PANTHER Pathway Component

mPer1
type: DnaRegion
entity reference: mPer1
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

PARTICIPANT STOICHIOMETRY re259 649
type: Stoichiometry
physical entity: COX2
stoichiometric coefficient: 1.0

P06858
type: UnificationXref
id: P06858
db: PANTHER Pathway Component

c-fos
type: DnaRegionReference
member entity reference: Proto-oncogene c-Fos
xref: G06894
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.c-fos
comment: ENTITY_REFERENCE_NOTES=GeneID: 14281

TRANSCRIPTION_LEFT__3_QUOTE_SINGLE_FSHbeta-RIGHT__FSHbeta-_re514
type: TemplateReaction
product: FSHbeta
xref: TRANSCRIPTION
participant: FSHbeta
participant: 3' FSHbeta
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

P06860
type: UnificationXref
id: P06860
db: PANTHER Pathway Component

P06861
type: UnificationXref
id: P06861
db: PANTHER Pathway Component

uniprot P70353 11
type: UnificationXref
id: P70353
db: uniprot

Id3
type: Protein
entity reference: Id3
feature: COMPLEX PARTICIPANT BINDING FEATURE s633 sa564 499
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

untitled
type: Pathway
pathway component: STATE_TRANSITION_LEFT__p38-RIGHT__3_QUOTE_SINGLE_FSHbeta-_re388
pathway component: STATE_TRANSITION_LEFT__p38-RIGHT__EGR1-_re276
pathway component: UNKNOWN_TRANSITION_LEFT__ERK1_2-RIGHT__Follistatin-_re325
pathway component: UNKNOWN_TRANSITION_LEFT__NFAT-RIGHT__Junc-_re584
pathway component: STATE_TRANSITION_LEFT__CREB-RIGHT__PACAP-_re612
pathway component: STATE_TRANSITION_LEFT__MASH1-RIGHT__GnRHR-_re624
pathway component: UNKNOWN_TRANSITION_LEFT__Linoleate-RIGHT__PKCe_theta-_re558
pathway component: HETERODIMER_ASSOCIATION_LEFT__Csda-_EGR1-RIGHT__EGR1_Csda-_re562
pathway component: STATE_TRANSITION_LEFT__EIF2AK3-RIGHT__EIF2A-_re266
pathway component: UNKNOWN_TRANSITION_LEFT__GnRHR-RIGHT__L_type_Ca2_PLUS_-_re347
pathway component: STATE_TRANSITION_LEFT__COX2-RIGHT__PGs-_re259
pathway component: STATE_TRANSITION_LEFT__SRC-RIGHT__Rac1-_re269
pathway component: STATE_TRANSITION_LEFT__SRF-RIGHT__c_fos-_re609
pathway component: STATE_TRANSITION_LEFT__p38-RIGHT__COX2-_re497
pathway component: STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__NOSI-_re345
pathway component: STATE_TRANSITION_LEFT__SMAD2_4_Pbx1_Prep1-RIGHT__3_QUOTE_SINGLE_FSHbeta-_re655
pathway component: STATE_TRANSITION_LEFT__SMAD2_4-RIGHT__SMAD2_4-_re332
pathway component: UNKNOWN_TRANSITION_LEFT__IRS-RIGHT__ERK1_2-_re451
pathway component: UNKNOWN_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__CNP-_re459
pathway component: UNKNOWN_TRANSITION_LEFT__Dnm1-RIGHT__Ras-_re484
pathway component: TRANSCRIPTION_LEFT__PACAP-RIGHT__PACAP-_re515
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re263
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__CREB-_re279
pathway component: STATE_TRANSITION_LEFT__CREB-RIGHT__GnRHR-_re623
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__5_QUOTE_SINGLE_FSHbeta-_re417
pathway component: STATE_TRANSITION_LEFT__IRS_1-RIGHT__AKT-_re452
pathway component: TRANSPORT_LEFT__CTNNB1-RIGHT__CTNNB1-_re641
pathway component: UNKNOWN_TRANSITION_LEFT__GnRH_GnRHR-RIGHT__Rap1b-_re570
pathway component: TRANSPORT_LEFT__STAT3-RIGHT__STAT3-_re522
pathway component: STATE_TRANSITION_LEFT__PR-RIGHT__5_QUOTE_SINGLE_FSHbeta-_re650
pathway component: STATE_TRANSITION_LEFT__ELK1_SRF-RIGHT__c_fos-_re607
pathway component: TRANSLATION_LEFT__Isl_1-RIGHT__Isl_1-_re525
pathway component: STATE_TRANSITION_LEFT__cGMP-RIGHT__CGA-_re430
pathway component: STATE_TRANSITION_LEFT__Pyk2_SRC_Grb2_Sos-RIGHT__Ras-_re12
pathway component: STATE_TRANSITION_LEFT__ATF2-RIGHT__CGA-_re646
pathway component: UNKNOWN_TRANSITION_LEFT__TORC1-RIGHT__CGA-_re589
pathway component: STATE_TRANSITION_LEFT__PKCs-RIGHT__Ras-_re475
pathway component: STATE_TRANSITION_LEFT__Alk4_ActivinA_ActRII_IIB-RIGHT__TAK1-_re225
pathway component: TRANSCRIPTION_LEFT__CGA-RIGHT__CGA-_re413
pathway component: TRANSLATION_LEFT__Atf3-RIGHT__Atf3-_re581
pathway component: STATE_TRANSITION_LEFT__IRS-RIGHT__PI3K-_re446
pathway component: STATE_TRANSITION_LEFT__PEA_15-RIGHT__PEA_15-_re532
pathway component: STATE_TRANSITION_LEFT__AC-RIGHT__cAMP-_re43
pathway component: STATE_TRANSITION_LEFT__AA-RIGHT__PKCs-_re489
pathway component: STATE_TRANSITION_LEFT__?-RIGHT__3_QUOTE_SINGLE_LHbeta-_re634
pathway component: UNKNOWN_TRANSITION_LEFT__NFAT-RIGHT__Atf3-_re585
pathway component: TRANSLATION_LEFT__Isl_1-RIGHT__Isl_1-_re524
pathway component: STATE_TRANSITION_LEFT__Activin_A_homodimer-RIGHT__ActRII_IIB-_re571
pathway component: STATE_TRANSITION_LEFT__alpha_beta_integrin_dimer-RIGHT__Pyk2_SRC_Grb2_Sos-_re479
pathway component: STATE_TRANSITION_LEFT__CTNNB1_SF1-RIGHT__5_QUOTE_SINGLE_LHbeta-_re640
pathway component: STATE_TRANSITION_LEFT__Caln-RIGHT__NFAT-_re492
pathway component: HETERODIMER_ASSOCIATION_LEFT__SRC_immune_complex-_GnRH-RIGHT__GnRH_SRC_immune_complex-_re661
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__MEK1_2-_re358
pathway component: TRANSCRIPTION_LEFT__3_QUOTE_SINGLE_LHbeta-RIGHT__LHbeta-_re510
pathway component: STATE_TRANSITION_LEFT__Npr2-RIGHT__GC-_re428
pathway component: STATE_TRANSITION_LEFT__AR-RIGHT__GnRHR-_re615
pathway component: UNKNOWN_TRANSITION_LEFT__p38-RIGHT__5_QUOTE_SINGLE_FSHbeta-_re227
pathway component: TRANSCRIPTION_LEFT__CNP-RIGHT__CNP-_re455
pathway component: STATE_TRANSITION_LEFT__CTNNB1-RIGHT__CTNNB1_TCF-_re399
pathway component: STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca_CaMK_II-_re254
pathway component: STATE_TRANSITION_LEFT__PITX-RIGHT__5_QUOTE_SINGLE_LHbeta-_re660
pathway component: TRANSLATION_LEFT__c_fos-RIGHT__FOS-_re546
pathway component: TRANSCRIPTION_LEFT__AK006051-RIGHT__miR_132_212-_re533
pathway component: UNKNOWN_TRANSITION_LEFT__PKCs-RIGHT__CREB-_re282
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__CREB-_re592
pathway component: TRANSCRIPTION_LEFT__COX2-RIGHT__COX2-_re273
pathway component: TRANSCRIPTION_LEFT__Glut1-RIGHT__Glut1-_re564
pathway component: STATE_TRANSITION_LEFT__PKCs-RIGHT__CREB-_re491
pathway component: STATE_TRANSITION_LEFT__MEK1_2-RIGHT__ERK1_2-_re555
pathway component: STATE_TRANSITION_LEFT__SF1-RIGHT__GnRHR-_re622
pathway component: STATE_TRANSITION_LEFT__PE-RIGHT__PKCs-_re488
pathway component: STATE_TRANSITION_LEFT__SRC-RIGHT__EGFR-_re473
pathway component: STATE_TRANSITION_LEFT__PPARalpha_gamma-RIGHT__Follistatin-_re394
pathway component: STATE_TRANSITION_LEFT__MAP3Ks-RIGHT__MKK4_7-_re320
pathway component: STATE_TRANSITION_LEFT__SRC-RIGHT__Ras-_re480
pathway component: STATE_TRANSITION_LEFT__SRC-RIGHT__Pyk2-_re476
pathway component: UNKNOWN_TRANSITION_LEFT__PKCs-RIGHT__FOS_JUN-_FOS_Jund-_re283
pathway component: STATE_TRANSITION_LEFT__OCT_1-RIGHT__GnRHR-_re620
pathway component: STATE_TRANSITION_LEFT__SMAD1_5_8-RIGHT__5_QUOTE_SINGLE_FSHbeta-_re553

Tubulin
type: Protein
entity reference: Tubulin
feature: COMPLEX PARTICIPANT BINDING FEATURE s867 sa696 455
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PACAP
type: DnaRegion
entity reference: PACAP
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

uniprot Q62048 74
type: UnificationXref
id: Q62048
db: uniprot

PARTICIPANT STOICHIOMETRY re259 650
type: Stoichiometry
physical entity: PGs
stoichiometric coefficient: 1.0

PR
type: Protein
entity reference: PR
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

INHIBITION
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__Activin_A_homodimer-_Alk4-RIGHT__Activin_A_homodimer-_re575
control type: INHIBITION
controller: Inha

DRD2
type: ProteinReference
xref: P06758
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.DRD2
comment: ENTITY_REFERENCE_NOTES= GeneID: 13489
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: D(2) dopamine receptor

P06847
type: UnificationXref
id: P06847
db: PANTHER Pathway Component

Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
type: ProteinReference
xref: uniprot Q6R0H7 208
xref: PTHR10218:SF320
organism: Mus musculus

P06846
type: UnificationXref
id: P06846
db: PANTHER Pathway Component

P06849
type: UnificationXref
id: P06849
db: PANTHER Pathway Component

Solute carrier family 2, facilitated glucose transporter member 1
type: DnaReference
organism: Mus musculus

P06848
type: UnificationXref
id: P06848
db: PANTHER Pathway Component

P06853
type: UnificationXref
id: P06853
db: PANTHER Pathway Component

P06854
type: UnificationXref
id: P06854
db: PANTHER Pathway Component

c-Raf
type: Protein
entity reference: c-Raf
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

P06855
type: UnificationXref
id: P06855
db: PANTHER Pathway Component

P06856
type: UnificationXref
id: P06856
db: PANTHER Pathway Component

SRC
type: Protein
entity reference: SRC
feature: COMPLEX PARTICIPANT BINDING FEATURE s496 sa511 405
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

P06850
type: UnificationXref
id: P06850
db: PANTHER Pathway Component

P06851
type: UnificationXref
id: P06851
db: PANTHER Pathway Component

P06852
type: UnificationXref
id: P06852
db: PANTHER Pathway Component

PPARgamma
type: Protein
entity reference: PPARgamma
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

NFAT
type: ProteinReference
xref: P06777
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.NFAT
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Nfatc1: GeneID: 18018; Nfatc2: GeneID: 18019; Nfatc3: GeneID: 18021; Nfatc4: GeneID: 73181 PMID: 19858197 GnRH signaling: increasing [Ca(2+)](i) causes calmodulin/calcineurin-dependent nuclear NFAT translocation, a response involving proteins (calmodulins and NFATs) that decode frequency in other systems.
member entity reference: Nuclear factor of activated T-cells, cytoplasmic 1
member entity reference: Nuclear factor of activated T-cells, cytoplasmic 2
member entity reference: Nuclear factor of activated T-cells, cytoplasmic 4
member entity reference: Nuclear factor of activated T-cells, cytoplasmic 3

PARTICIPANT STOICHIOMETRY re612 770
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re612 771
type: Stoichiometry
physical entity: PACAP
stoichiometric coefficient: 1.0

Paxillin
type: Protein
entity reference: Paxillin
feature: COMPLEX PARTICIPANT BINDING FEATURE s868 sa697 457
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P62880 193
type: UnificationXref
id: P62880
db: uniprot

STAT3
type: Protein
entity reference: STAT3
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot P31938 42
organism: Mus musculus

STATE_TRANSITION_LEFT__PKA-RIGHT__ER-_re469
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re469 940
participant stoichiometry: PARTICIPANT STOICHIOMETRY re469 941
left: PKA
interaction type: STATE_TRANSITION
right: ER

GnRHR
type: Protein
entity reference: GnRHR
feature: COMPLEX PARTICIPANT BINDING FEATURE s849 sa1 297
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot P70227 93
xref: PTHR13715:SF51
organism: Mus musculus

SMAD1/5/8
type: Protein
entity reference: SMAD1/5/8
feature: SMAD1 5 8 s690 sa620 rs1
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P09450 228
type: UnificationXref
id: P09450
db: uniprot

Rac1
type: ProteinReference
xref: P06860
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Rac1
comment: ENTITY_REFERENCE_NOTES= GeneID: 19353
member entity reference: Ras-related C3 botulinum toxin substrate 1

Activin A homodimer s719 csa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Activin A homodimer
stoichiometric coefficient: 1.0

uniprot P33242 178
type: UnificationXref
id: P33242
db: uniprot

uniprot Q9Z2B5 90
type: UnificationXref
id: Q9Z2B5
db: uniprot

uniprot P70218 16
type: UnificationXref
id: P70218
db: uniprot

MKK4/7
type: Protein
entity reference: MKK4/7
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Early growth response protein 1
type: DnaReference
organism: Mus musculus

UNKNOWN_TRANSITION
type: InteractionVocabulary

SP3
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s478 sa500 503
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

TRANSLATION
type: InteractionVocabulary

uniprot Q02111 229
type: UnificationXref
id: Q02111
db: uniprot

PARTICIPANT STOICHIOMETRY re335 561
type: Stoichiometry
physical entity: Alk4_ActivinA_ActRII/IIB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re335 562
type: Stoichiometry
physical entity: Pbx1
stoichiometric coefficient: 1.0

FOS_Jund
type: Complex
component stoichiometry: Jund s481 sa507 STOICHIOMETRY ID COMPLEX
component stoichiometry: FOS s824 sa508 STOICHIOMETRY ID COMPLEX
component: FOS
component: Jund
feature: COMPLEX BINDING FEATURE s823 csa64 384
feature: COMPLEX BINDING FEATURE s823 csa64 382
cellular location: Nucleus

PTHR13809:SF25
type: RelationshipXref
id: PTHR13809:SF25
db: PANTHER Family
relationship type: By Homology

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: PTHR48013:SF12
xref: uniprot P70236 32
organism: Mus musculus

GnRH
type: ProteinReference
xref: P06704
comment: ENTITY_REFERENCE_NOTES= GeneID: 14714
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.GnRH
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Progonadoliberin-1

UNKNOWN_TRANSITION_LEFT__GnRHR-RIGHT__TGIF1-_re550
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re550 854
participant stoichiometry: PARTICIPANT STOICHIOMETRY re550 855
left: GnRHR
interaction type: UNKNOWN_TRANSITION
right: TGIF1

UNKNOWN_TRANSITION
type: Control
xref: UNKNOWN TRANSITION
controlled: Cell Survival
controller: AKT

STATE_TRANSITION_LEFT__JNK1_2-RIGHT__Junc-_re389
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re389 994
participant stoichiometry: PARTICIPANT STOICHIOMETRY re389 995
left: JNK1/2
interaction type: STATE_TRANSITION
right: Junc

SRC s499 sa348 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re647 660
type: Stoichiometry
physical entity: 3' FSHbeta
stoichiometric coefficient: 1.0

EGR1_Csda
type: Complex
component stoichiometry: Csda s698 sa630 STOICHIOMETRY ID COMPLEX
component: Csda
feature: COMPLEX BINDING FEATURE s761 csa24 524
cellular location: Nucleus

GnRHR s810 sa679 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

Transforming growth factor beta receptor type 3
type: ProteinReference
xref: uniprot O88393 177
organism: Mus musculus

UNKNOWN_TRANSITION_LEFT__nPKCs-RIGHT__AC-_re328
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re328 574
participant stoichiometry: PARTICIPANT STOICHIOMETRY re328 573
left: nPKCs
interaction type: UNKNOWN_TRANSITION
right: AC

Synaptotagmin-4
type: ProteinReference
xref: uniprot P40749 13
organism: Mus musculus

Cyclic AMP-dependent transcription factor ATF-3
type: ProteinReference
xref: PTHR23351:SF23
xref: uniprot Q60765 73
organism: Mus musculus

SP1
type: Protein
entity reference: SP1
feature: COMPLEX PARTICIPANT BINDING FEATURE s818 sa499 501
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

AA
type: SmallMolecule
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re656 638
type: Stoichiometry
physical entity: 3' FSHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re656 637
type: Stoichiometry
physical entity: SMAD2-4
stoichiometric coefficient: 1.0

CTNNB1_TCF
type: Complex
component stoichiometry: CTNNB1 s533 sa407 STOICHIOMETRY ID COMPLEX
component stoichiometry: TCF s74 sa406 STOICHIOMETRY ID COMPLEX
component: CTNNB1
component: TCF
feature: COMPLEX BINDING FEATURE s753 csa13 366
feature: COMPLEX BINDING FEATURE s753 csa13 368
cellular location: Nucleus

PARTICIPANT STOICHIOMETRY re336 559
type: Stoichiometry
physical entity: AA
stoichiometric coefficient: 1.0

Activin A homodimer s729 csa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Activin A homodimer
stoichiometric coefficient: 1.0

IGF-1R
type: Protein
entity reference: IGF-1R
feature: COMPLEX PARTICIPANT BINDING FEATURE s468 sa481 485
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR10082:SF28
type: RelationshipXref
id: PTHR10082:SF28
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re647 659
type: Stoichiometry
physical entity: Isl-1
stoichiometric coefficient: 1.0

PTHR11848:SF125
type: RelationshipXref
id: PTHR11848:SF125
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re488 902
type: Stoichiometry
physical entity: PE
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re488 903
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

Nuclear factor of activated T-cells, cytoplasmic 3
type: ProteinReference
xref: PTHR12533:SF6
xref: uniprot P97305 105
organism: Mus musculus

5' FSHbeta
type: DnaRegion
entity reference: 5' FSHbeta
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

STATE_TRANSITION_LEFT__CBP-RIGHT__CBP-_re586
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re586 749
participant stoichiometry: PARTICIPANT STOICHIOMETRY re586 748
left: CBP
interaction type: STATE_TRANSITION
right: CBP

PAC1R
type: RnaRegionReference
comment: ENTITY_REFERENCE_NOTES=Gene ID: 11517
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.PAC1R

Adiponectin receptor protein 1
type: ProteinReference
xref: uniprot Q91VH1 52
organism: Mus musculus

STATE_TRANSITION_LEFT__ER-RIGHT__EGR1-_re287
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re287 588
participant stoichiometry: PARTICIPANT STOICHIOMETRY re287 587
left: ER
interaction type: STATE_TRANSITION
right: EGR1

SMAD2 4 s683 sa339 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.39269908169872414

UNKNOWN_TRANSITION_LEFT__ERK1_2-RIGHT__FOS-_re216
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re216 784
participant stoichiometry: PARTICIPANT STOICHIOMETRY re216 785
left: ERK1/2
interaction type: UNKNOWN_TRANSITION
right: FOS

Insulin receptor substrate 2
type: ProteinReference
xref: uniprot P81122 183
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re483 915
type: Stoichiometry
physical entity: Dnm1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re483 914
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

Protein fosB
type: ProteinReference
xref: uniprot P13346 97
organism: Mus musculus

Gonadotropin-releasing hormone receptor
type: DnaReference
xref: PTHR24241:SF22
organism: Mus musculus

Insulin-like growth factor 1 receptor
type: ProteinReference
xref: PTHR24416:SF106
xref: uniprot Q60751 234
organism: Mus musculus

PTHR11866:SF10
type: RelationshipXref
id: PTHR11866:SF10
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Npr2-RIGHT__GC-_re428
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re428 987
participant stoichiometry: PARTICIPANT STOICHIOMETRY re428 986
left: Npr2
interaction type: STATE_TRANSITION
right: GC

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q02111 229
organism: Mus musculus

Diacylglycerol kinase zeta
type: ProteinReference
xref: uniprot Q80UP3 110
organism: Mus musculus

TRANSLATION_LEFT__Nur77-RIGHT__Nur77-_re423
type: TemplateReaction
product: Nur77
xref: TRANSLATION
participant: Nur77
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

Bone morphogenetic protein 2
type: ProteinReference
xref: PTHR11848:SF143
xref: uniprot P21274 213
organism: Mus musculus

Bone morphogenetic protein 4
type: ProteinReference
xref: uniprot P21275 214
xref: PTHR11848:SF165
organism: Mus musculus

PTHR11848:SF135
type: RelationshipXref
id: PTHR11848:SF135
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca_CaMK_II-_re254
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re254 652
participant stoichiometry: PARTICIPANT STOICHIOMETRY re254 651
left: Ca2+
interaction type: STATE_TRANSITION
right: Ca/CaMK II

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot P21278 101
organism: Mus musculus

PTHR11848:SF137
type: RelationshipXref
id: PTHR11848:SF137
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot P21279 102
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re641 672
type: Stoichiometry
physical entity: CTNNB1
stoichiometric coefficient: 1.0

AKT
type: Protein
entity reference: AKT
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re641 673
type: Stoichiometry
physical entity: CTNNB1
stoichiometric coefficient: 1.0

GnRH_GnRHR
type: Complex
component stoichiometry: GnRH s811 sa680 STOICHIOMETRY ID COMPLEX
component stoichiometry: GnRHR s810 sa679 STOICHIOMETRY ID COMPLEX
component: GnRH
component: GnRHR
feature: COMPLEX BINDING FEATURE s805 csa57 248
feature: COMPLEX PARTICIPANT BINDING FEATURE s805 csa57 251
feature: COMPLEX BINDING FEATURE s805 csa57 246
cellular location: Cytoplasm

STATE_TRANSITION_LEFT__AA-RIGHT__PKCs-_re489
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re489 899
participant stoichiometry: PARTICIPANT STOICHIOMETRY re489 898
left: AA
interaction type: STATE_TRANSITION
right: PKCs

Mitogen-activated protein kinase kinase kinase 12
type: ProteinReference
xref: uniprot Q60700 159
organism: Mus musculus

STATE_TRANSITION_LEFT__MAP3Ks-RIGHT__MKK4_7-_re320
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re320 586
participant stoichiometry: PARTICIPANT STOICHIOMETRY re320 585
left: MAP3Ks
interaction type: STATE_TRANSITION
right: MKK4/7

PKCs 3 s873 sa702 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PKCs(3)
stoichiometric coefficient: 1.0

Nuclear receptor coactivator 3
type: ProteinReference
xref: uniprot O09000 129
organism: Mus musculus

Adiponectin
type: ProteinReference
xref: P06761
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Adiponectin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= GeneID: 11450
member entity reference: Adiponectin

CGA
type: DnaRegion
entity reference: CGA
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

Protein kinase C beta type
type: ProteinReference
xref: uniprot P68404 27
xref: PTHR24356:SF158
organism: Mus musculus

Caveolin-1
type: ProteinReference
xref: uniprot P49817 81
xref: PTHR10844:SF18
organism: Mus musculus

PTHR11848:SF143
type: RelationshipXref
id: PTHR11848:SF143
db: PANTHER Family
relationship type: By Homology

Dynamin-1
type: ProteinReference
xref: uniprot P39053 103
organism: Mus musculus

PTHR11848:SF141
type: RelationshipXref
id: PTHR11848:SF141
db: PANTHER Family
relationship type: By Homology

LHbeta
type: ProteinReference
xref: P06751
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.LHbeta
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 16866
member entity reference: Lutropin subunit beta

Histone acetyltransferase KAT2B
type: ProteinReference
xref: PTHR45750:SF2
xref: uniprot Q9JHD1 111
organism: Mus musculus

ECM s816 sa672 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ECM
stoichiometric coefficient: 1.0

PANTHER Pathway P06664 1
type: UnificationXref
id: P06664
db: PANTHER Pathway

PARTICIPANT STOICHIOMETRY re558 842
type: Stoichiometry
physical entity: Linoleate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re558 843
type: Stoichiometry
physical entity: PKCe/theta
stoichiometric coefficient: 1.0

GnRH_SRC immune complex
type: Complex
component stoichiometry: Paxillin s868 sa697 STOICHIOMETRY ID COMPLEX
component stoichiometry: FAK s871 sa700 STOICHIOMETRY ID COMPLEX
component stoichiometry: PKCs 3 s873 sa702 STOICHIOMETRY ID COMPLEX
component stoichiometry: SRC s877 sa706 STOICHIOMETRY ID COMPLEX
component stoichiometry: MEK1 2 s874 sa703 STOICHIOMETRY ID COMPLEX
component stoichiometry: Tubulin s867 sa696 STOICHIOMETRY ID COMPLEX
component stoichiometry: ERK1 2 s875 sa704 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ras s876 sa705 STOICHIOMETRY ID COMPLEX
component stoichiometry: Caveolin 1 s870 sa699 STOICHIOMETRY ID COMPLEX
component stoichiometry: GnRH s879 sa709 STOICHIOMETRY ID COMPLEX
component stoichiometry: GnRHR s878 sa707 STOICHIOMETRY ID COMPLEX
component stoichiometry: Vinculin s869 sa698 STOICHIOMETRY ID COMPLEX
component stoichiometry: KSR 1 s872 sa701 STOICHIOMETRY ID COMPLEX
component: FAK
component: Tubulin
component: Paxillin
component: KSR-1
component: GnRHR
component: PKCs(3)
component: MEK1/2
component: Vinculin
component: SRC
component: Caveolin-1
component: Ras
component: GnRH
component: ERK1/2
feature: COMPLEX BINDING FEATURE s880 csa75 472
feature: COMPLEX BINDING FEATURE s880 csa75 466
feature: COMPLEX BINDING FEATURE s880 csa75 456
feature: COMPLEX BINDING FEATURE s880 csa75 468
feature: COMPLEX BINDING FEATURE s880 csa75 454
feature: COMPLEX BINDING FEATURE s880 csa75 462
feature: COMPLEX BINDING FEATURE s880 csa75 478
feature: COMPLEX BINDING FEATURE s880 csa75 476
feature: COMPLEX BINDING FEATURE s880 csa75 460
feature: COMPLEX BINDING FEATURE s880 csa75 458
feature: COMPLEX BINDING FEATURE s880 csa75 474
feature: COMPLEX BINDING FEATURE s880 csa75 470
feature: COMPLEX BINDING FEATURE s880 csa75 464
cellular location: Cytoplasm

PPARalpha/gamma
type: Protein
entity reference: PPARalpha/gamma
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PKA-RIGHT__CREB-_re625
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re625 727
participant stoichiometry: PARTICIPANT STOICHIOMETRY re625 726
left: PKA
interaction type: STATE_TRANSITION
right: CREB

Ca2+
type: SmallMolecule
cellular location: Cytoplasm
comment: SPECIES_TYPE=ION

PARTICIPANT STOICHIOMETRY re648 658
type: Stoichiometry
physical entity: 5' FSHbeta
stoichiometric coefficient: 1.0

MIS_MISRII
type: Complex
component stoichiometry: MISRII s148 sa210 STOICHIOMETRY ID COMPLEX
component stoichiometry: MIS s199 sa258 STOICHIOMETRY ID COMPLEX
component: MISRII
component: MIS
feature: COMPLEX BINDING FEATURE s768 csa39 430
feature: COMPLEX BINDING FEATURE s768 csa39 432
cellular location: Cytoplasm

PARTICIPANT STOICHIOMETRY re648 657
type: Stoichiometry
physical entity: NF-Y_JUN_FOS
stoichiometric coefficient: 1.0

uniprot P41969 197
type: UnificationXref
id: P41969
db: uniprot

Bone morphogenetic protein receptor type-2
type: ProteinReference
xref: uniprot O35607 120
xref: PTHR23255:SF63
organism: Mus musculus

Rho GTPase-activating protein 32
type: ProteinReference
xref: uniprot Q811P8 179
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re251 654
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re396 975
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re396 974
type: Stoichiometry
physical entity: MT1-MMP
stoichiometric coefficient: 1.0

Serotonin s198 sa257 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Serotonin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re251 653
type: Stoichiometry
physical entity: PLCbeta
stoichiometric coefficient: 1.0

Pituitary adenylate cyclase-activating polypeptide type I receptor
type: ProteinReference
xref: uniprot P70205 15
organism: Mus musculus

Cell mitosis
type: Pathway

STATE_TRANSITION_LEFT__PITX-RIGHT__3_QUOTE_SINGLE_FSHbeta-_re652
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re652 646
participant stoichiometry: PARTICIPANT STOICHIOMETRY re652 645
left: PITX
interaction type: STATE_TRANSITION
right: 3' FSHbeta

PLA2
type: Protein
entity reference: PLA2
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mothers against decapentaplegic homolog 3
type: ProteinReference
xref: uniprot Q8BUN5 116
xref: PTHR13703:SF53
organism: Mus musculus

PTHR11848:SF165
type: RelationshipXref
id: PTHR11848:SF165
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re430 972
type: Stoichiometry
physical entity: cGMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re430 973
type: Stoichiometry
physical entity: CGA
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CTNNB1-RIGHT__CTNNB1_TCF-_re399
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re399 969
participant stoichiometry: PARTICIPANT STOICHIOMETRY re399 968
left: CTNNB1
interaction type: STATE_TRANSITION
right: CTNNB1_TCF

Dual specificity protein phosphatase 1
type: ProteinReference
xref: PTHR10159:SF309
xref: uniprot P28563 235
organism: Mus musculus

ERK1 2 s875 sa704 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

SMAD2 4 s595 sa342 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.39269908169872414

Period circadian protein homolog 1
type: DnaReference
xref: PTHR11269:SF8
organism: Mus musculus

uniprot Q61122 133
type: UnificationXref
id: Q61122
db: uniprot

uniprot Q8VI36 99
type: UnificationXref
id: Q8VI36
db: uniprot

Mitogen-activated protein kinase kinase kinase kinase 1
type: ProteinReference
xref: uniprot P70218 16
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re659 631
type: Stoichiometry
physical entity: Atf3
stoichiometric coefficient: 1.0

uniprot B2RWS6 238
type: UnificationXref
id: B2RWS6
db: uniprot

GPR147 74 s733 sa652 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GPR147/74
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re659 632
type: Stoichiometry
physical entity: CGA
stoichiometric coefficient: 1.0

Dopamine_DRD2_gnai/o
type: Complex
component stoichiometry: gnai o s163 sa219 STOICHIOMETRY ID COMPLEX
component stoichiometry: Dopamine s194 sa253 STOICHIOMETRY ID COMPLEX
component stoichiometry: DRD2 s19 sa397 STOICHIOMETRY ID COMPLEX
component: gnai/o
component: DRD2
component: Dopamine
feature: COMPLEX BINDING FEATURE s771 csa40 334
feature: COMPLEX BINDING FEATURE s771 csa40 336
feature: COMPLEX BINDING FEATURE s771 csa40 332
cellular location: Cytoplasm

uniprot Q9WUI1 86
type: UnificationXref
id: Q9WUI1
db: uniprot

mPer1
type: DnaRegionReference
member entity reference: Period circadian protein homolog 1
xref: G06895
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.mPer1
comment: ENTITY_REFERENCE_NOTES=GeneID: 18626

PARTICIPANT STOICHIOMETRY re492 886
type: Stoichiometry
physical entity: Caln
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re492 887
type: Stoichiometry
physical entity: NFAT
stoichiometric coefficient: 1.0

PAC1-R
type: Protein
entity reference: PAC1-R
feature: COMPLEX PARTICIPANT BINDING FEATURE s283 sa334 293
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re601 817
type: Stoichiometry
physical entity: Pcaf_ER
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re601 818
type: Stoichiometry
physical entity: Fosb
stoichiometric coefficient: 1.0

CLIM2
type: Protein
entity reference: CLIM2
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

SMAD2-4
type: Protein
entity reference: SMAD2-4
feature: SMAD2 4 s683 sa339 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s683 sa339 509
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re628 721
type: Stoichiometry
physical entity: 5' LHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re628 720
type: Stoichiometry
physical entity: EGR1
stoichiometric coefficient: 1.0

Ras s876 sa705 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PACAP
type: ProteinReference
xref: P06800
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PACAP
comment: ENTITY_REFERENCE_NOTES= GeneID: 11516
member entity reference: Pituitary adenylate cyclase-activating polypeptide

5'-AMP-activated protein kinase catalytic subunit alpha-1
type: ProteinReference
xref: uniprot Q5EG47 217
organism: Mus musculus

GnRH s811 sa680 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GnRH
stoichiometric coefficient: 1.0

Ncoa3 s459 sa479 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ncoa3
stoichiometric coefficient: 1.0

Id3 s633 sa564 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Id3
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PKA-RIGHT__MEK1_2-_re358
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re358 542
participant stoichiometry: PARTICIPANT STOICHIOMETRY re358 541
left: PKA
interaction type: STATE_TRANSITION
right: MEK1/2

GC
type: ProteinReference
xref: P06726
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Gucy1b3: GeneID: 54195; Gucy1b2: GeneID: 239134;
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.GC
member entity reference: Guanylate cyclase 1, soluble, beta 2
member entity reference: Guanylate cyclase soluble subunit beta-1

Vinculin
type: Protein
entity reference: Vinculin
feature: COMPLEX PARTICIPANT BINDING FEATURE s869 sa698 459
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

GnRHR s803 sa681 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re576 782
type: Stoichiometry
physical entity: Alk4
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__12_LO-RIGHT__LTs-_re337
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re337 557
participant stoichiometry: PARTICIPANT STOICHIOMETRY re337 558
left: 12-LO
interaction type: STATE_TRANSITION
right: LTs

PARTICIPANT STOICHIOMETRY re576 783
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

SRC
type: Protein
entity reference: SRC
feature: COMPLEX PARTICIPANT BINDING FEATURE s862 sa532 327
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

gnaq/11
type: ProteinReference
xref: P06841
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.gnaq/11
comment: ENTITY_REFERENCE_NOTES= Gnaq: GeneID: 14682; Gna11: GeneID: 14672
member entity reference: Guanine nucleotide-binding protein subunit alpha-11
member entity reference: Guanine nucleotide-binding protein G(q) subunit alpha

GnRH
type: Protein
entity reference: GnRH
feature: COMPLEX PARTICIPANT BINDING FEATURE s804 sa682 257
comment: SPECIES_TYPE=PROTEIN

Ca/CaMK II
type: ProteinReference
xref: P06735
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 12323
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Ca/CaMK II
member entity reference: Calcium/calmodulin-dependent protein kinase type II subunit beta

uniprot P01101 96
type: UnificationXref
id: P01101
db: uniprot

PRLR
type: ProteinReference
xref: P06822
comment: ENTITY_REFERENCE_NOTES= GeneID: 19116
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.PRLR
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Prolactin receptor

alpha-beta integrin dimer
type: Complex
component stoichiometry: alpha beta integrin dimer s815 sa671 STOICHIOMETRY ID COMPLEX
component: alpha-beta integrin dimer
feature: COMPLEX PARTICIPANT BINDING FEATURE s815 sa671 391

alpha-beta integrin dimer
type: Complex
component stoichiometry: alpha beta integrin dimer s786 sa30 STOICHIOMETRY ID COMPLEX
component: alpha-beta integrin dimer
feature: COMPLEX PARTICIPANT BINDING FEATURE s786 sa30 387
cellular location: Cytoplasm

ActRII/IIB
type: Protein
entity reference: ActRII/IIB
feature: COMPLEX PARTICIPANT BINDING FEATURE s726 sa643 425
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

p300 s164 sa220 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p300
stoichiometric coefficient: 1.0

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: go GO:0005783 3

PARTICIPANT STOICHIOMETRY re494 885
type: Stoichiometry
physical entity: COX2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re494 884
type: Stoichiometry
physical entity: PLA2
stoichiometric coefficient: 1.0

5' LHbeta
type: DnaRegionReference
member entity reference: Lutropin subunit beta
xref: G06889
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.5' LHbeta
comment: ENTITY_REFERENCE_NOTES=GeneID: 16866

Pyk2
type: ProteinReference
xref: P06730
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 19229
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Pyk2
member entity reference: Protein-tyrosine kinase 2-beta

Prolactin
type: Protein
entity reference: Prolactin
feature: COMPLEX PARTICIPANT BINDING FEATURE s195 sa254 375
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

FSHbeta
type: Protein
entity reference: FSHbeta
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot P16054 24
organism: Mus musculus

Alk4 s709 sa640 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Alk4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re572 792
type: Stoichiometry
physical entity: Activin A homodimer
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re572 791
type: Stoichiometry
physical entity: ActRII/IIB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re582 758
type: Stoichiometry
physical entity: Caln
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re358 541
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

Glucocorticoid receptor
type: ProteinReference
xref: uniprot P06537 68
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re582 759
type: Stoichiometry
physical entity: NFAT
stoichiometric coefficient: 1.0

Eukaryotic translation initiation factor 2-alpha kinase 3
type: ProteinReference
xref: uniprot Q9Z2B5 90
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re358 542
type: Stoichiometry
physical entity: MEK1/2
stoichiometric coefficient: 1.0

CNP
type: DnaRegion
entity reference: CNP
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

IGF-1_IGF-1R_IRS
type: Complex
component stoichiometry: IGF 1R s468 sa481 STOICHIOMETRY ID COMPLEX
component stoichiometry: IRS s470 sa483 STOICHIOMETRY ID COMPLEX
component stoichiometry: IGF 1 s469 sa482 STOICHIOMETRY ID COMPLEX
component: IGF-1
component: IRS
component: IGF-1R
feature: COMPLEX BINDING FEATURE s779 csa48 488
feature: COMPLEX BINDING FEATURE s779 csa48 486
feature: COMPLEX BINDING FEATURE s779 csa48 484
cellular location: Cytoplasm

TRANSPORT_LEFT__STAT3-RIGHT__STAT3-_re522
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re522 897
participant stoichiometry: PARTICIPANT STOICHIOMETRY re522 896
left: STAT3
interaction type: TRANSPORT
right: STAT3

PTHR10005:SF3
type: RelationshipXref
id: PTHR10005:SF3
db: PANTHER Family
relationship type: By Homology

L-type Ca2+
type: ProteinReference
xref: P06812
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.ION_CHANNEL.L-type Ca2+
comment: ENTITY_REFERENCE_NOTES=Cacna1c: GeneID: 12288 ; Cacna1d: GeneID: 12289 ; Cacna1s: GeneID: 12292 ; Cacna1f: GeneID: 54652
member entity reference: Voltage-dependent L-type calcium channel subunit alpha-1F
member entity reference: Voltage-dependent L-type calcium channel subunit alpha-1D
member entity reference: Voltage-dependent L-type calcium channel subunit alpha-1S
member entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

STATE_TRANSITION_LEFT__SF1-RIGHT__GnRHR-_re622
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re622 732
participant stoichiometry: PARTICIPANT STOICHIOMETRY re622 733
left: SF1
interaction type: STATE_TRANSITION
right: GnRHR

GnRHR
type: DnaRegionReference
member entity reference: Gonadotropin-releasing hormone receptor
xref: G06892
comment: ENTITY_REFERENCE_NOTES=GeneID: 14715
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.GnRHR

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

GnRH_GnRHR_gnaq/11
type: Complex
component stoichiometry: gnaq 11 s3 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: GnRH GnRHR s809 csa58 STOICHIOMETRY ID COMPLEX
component: GnRH_GnRHR
component: gnaq/11
feature: COMPLEX BINDING FEATURE s792 csa53 260
feature: COMPLEX BINDING FEATURE s792 csa53 258
cellular location: Cytoplasm

IGF 1 s469 sa482 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IGF-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re470 934
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re470 935
type: Stoichiometry
physical entity: ER
stoichiometric coefficient: 1.0

SMAD2-4_Pbx1_Prep1
type: Complex
component stoichiometry: Pbx1 s140 sa200 STOICHIOMETRY ID COMPLEX
component stoichiometry: Prep1 s138 sa198 STOICHIOMETRY ID COMPLEX
component stoichiometry: SMAD2 4 s595 sa342 STOICHIOMETRY ID COMPLEX
component: Pbx1
component: Prep1
component: SMAD2-4
feature: COMPLEX BINDING FEATURE s839 csa70 450
feature: COMPLEX BINDING FEATURE s839 csa70 452
feature: COMPLEX BINDING FEATURE s839 csa70 448
cellular location: Nucleus

Insulin-like growth factor I
type: ProteinReference
xref: uniprot P05017 237
organism: Mus musculus

NOSI
type: RnaRegion
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

uniprot P18872 243
type: UnificationXref
id: P18872
db: uniprot

TRANSCRIPTION_LEFT__Atf3-RIGHT__Atf3-_re580
type: TemplateReaction
product: Atf3
xref: TRANSCRIPTION
participant: Atf3
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot P05213 130
type: UnificationXref
id: P05213
db: uniprot

STATE_TRANSITION_LEFT__SMAD1_5_8-RIGHT__5_QUOTE_SINGLE_FSHbeta-_re553
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re553 848
participant stoichiometry: PARTICIPANT STOICHIOMETRY re553 849
left: SMAD1/5/8
interaction type: STATE_TRANSITION
right: 5' FSHbeta

PARTICIPANT STOICHIOMETRY re334 564
type: Stoichiometry
physical entity: SMAD2-4
stoichiometric coefficient: 1.0

Follistatin
type: ProteinReference
xref: uniprot P47931 8
organism: Mus musculus

PKCs
type: Protein
entity reference: PKCs
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s620 sa553 381
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P21275 214
type: UnificationXref
id: P21275
db: uniprot

PARTICIPANT STOICHIOMETRY re334 563
type: Stoichiometry
physical entity: SMAD2-4
stoichiometric coefficient: 1.0

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__cAMP-_re43
control type: INHIBITION
controller: PGs

PTHR11771:SF33
type: RelationshipXref
id: PTHR11771:SF33
db: PANTHER Family
relationship type: By Homology

LH secretion
type: Pathway

PARTICIPANT STOICHIOMETRY re522 897
type: Stoichiometry
physical entity: STAT3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re522 896
type: Stoichiometry
physical entity: STAT3
stoichiometric coefficient: 1.0

GnRHR s863 sa519 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__EGR1-RIGHT__mPer1-_re643
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re643 667
participant stoichiometry: PARTICIPANT STOICHIOMETRY re643 668
left: EGR1
interaction type: STATE_TRANSITION
right: mPer1

EIF2AK3
type: Protein
entity reference: EIF2AK3
cellular location: Endoplasmic Reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot Q9Z329 94
type: UnificationXref
id: Q9Z329
db: uniprot

Ncoa3
type: Protein
entity reference: Ncoa3
feature: COMPLEX PARTICIPANT BINDING FEATURE s459 sa479 281
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

COX2
type: ProteinReference
xref: P06734
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.COX2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 5912281
member entity reference: Cytochrome c oxidase subunit 2

NF-Y
type: ProteinReference
xref: P06742
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.NF-Y
comment: ENTITY_REFERENCE_NOTES=Nfya: GeneID: 18044 ; Nfyb: GeneID: 18045 ; Nfyc: GeneID: 18046 PMID: 15388790 It is shown that NF-Y binds to SURG-1 element on the GnRH receptor promoter. By GnRH exposure, NF-Y binding to GnRH receptor promoter is increased.
member entity reference: Nuclear transcription factor Y subunit gamma
member entity reference: Nuclear transcription factor Y subunit beta
member entity reference: Nuclear transcription factor Y subunit alpha

SMAD2 4 s684 sa233 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMAD2-4
stoichiometric coefficient: 1.0

COX2
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.COX2
comment: ENTITY_REFERENCE_NOTES=GeneID: 5912281

Steroidogenic factor 1
type: ProteinReference
xref: uniprot P33242 178
organism: Mus musculus

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__MKK4_7-RIGHT__JNK1_2-_re321
control type: INHIBITION
controller: PPARgamma

PG Rcs
type: Protein
entity reference: PG Rcs
feature: COMPLEX PARTICIPANT BINDING FEATURE s630 sa561 287
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q99246 58
type: UnificationXref
id: Q99246
db: uniprot

PARTICIPANT STOICHIOMETRY re276 606
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re276 607
type: Stoichiometry
physical entity: EGR1
stoichiometric coefficient: 1.0

TAK1
type: ProteinReference
xref: P06799
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 26409
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.TAK1
member entity reference: Mitogen-activated protein kinase kinase kinase 7

uniprot Q9Z1B7 87
type: UnificationXref
id: Q9Z1B7
db: uniprot

STATE_TRANSITION_LEFT__MEK1_2-RIGHT__ERK1_2-_re5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 527
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 526
left: MEK1/2
interaction type: STATE_TRANSITION
right: ERK1/2

SP1
type: Protein
entity reference: SP1
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

UNKNOWN_TRANSITION_LEFT__GnRHR-RIGHT__SKIL-_re549
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re549 858
participant stoichiometry: PARTICIPANT STOICHIOMETRY re549 859
left: GnRHR
interaction type: UNKNOWN_TRANSITION
right: SKIL

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 141
xref: PTHR44329:SF22
xref: uniprot Q99N57 140
organism: Mus musculus

go GO:0005634 4
type: UnificationXref
id: GO:0005634
db: go

CREB
type: Protein
entity reference: CREB
feature: COMPLEX PARTICIPANT BINDING FEATURE s747 sa669 263
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

RICS
type: DnaRegionReference
member entity reference: Rho GTPase-activating protein 32
xref: G06882
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.RICS
comment: ENTITY_REFERENCE_NOTES=Gene ID: 330914

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 40

SRC s496 sa511 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re446 962
type: Stoichiometry
physical entity: IRS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re446 963
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

Bone morphogenetic protein receptor type-1A
type: ProteinReference
xref: uniprot P36895 121
xref: PTHR23255:SF50
organism: Mus musculus

Scg2
type: DnaRegion
entity reference: Scg2
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

Bone morphogenetic protein receptor type-1B
type: ProteinReference
xref: PTHR23255:SF62
xref: uniprot P36898 122
organism: Mus musculus

ER
type: Protein
entity reference: ER
feature: COMPLEX PARTICIPANT BINDING FEATURE s609 sa464 353
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re596 701
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re596 702
type: Stoichiometry
physical entity: Cdc42
stoichiometric coefficient: 1.0

Cytoplasm
type: CellularLocationVocabulary
xref: go GO:0005737 5

STATE_TRANSITION_LEFT__p38-RIGHT__ELK1-_re547
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re547 863
participant stoichiometry: PARTICIPANT STOICHIOMETRY re547 862
left: p38
interaction type: STATE_TRANSITION
right: ELK1

PI3K
type: Protein
entity reference: PI3K
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q00175 148
type: UnificationXref
id: Q00175
db: uniprot

uniprot Q08369 119
type: UnificationXref
id: Q08369
db: uniprot

Follitropin subunit beta
type: ProteinReference
xref: uniprot Q60687 242
organism: Mus musculus

BMP7
type: RnaRegion
entity reference: BMP7
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

Fosb
type: DnaRegionReference
member entity reference: Protein fosB
xref: G06878
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.Fosb
comment: ENTITY_REFERENCE_NOTES=GeneID: 14282

STATE_TRANSITION_LEFT__PKA-RIGHT__CREB-_re592
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re592 706
participant stoichiometry: PARTICIPANT STOICHIOMETRY re592 705
left: PKA
interaction type: STATE_TRANSITION
right: CREB

PARTICIPANT STOICHIOMETRY re321 583
type: Stoichiometry
physical entity: MKK4/7
stoichiometric coefficient: 1.0

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__SMAD2_4-RIGHT__3_QUOTE_SINGLE_FSHbeta-_re656
control type: INHIBITION
controller: Runx2

PARTICIPANT STOICHIOMETRY re321 584
type: Stoichiometry
physical entity: JNK1/2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ERK1_2-RIGHT__ELK1-_re548
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re548 861
participant stoichiometry: PARTICIPANT STOICHIOMETRY re548 860
left: ERK1/2
interaction type: STATE_TRANSITION
right: ELK1

uniprot Q8BUN5 116
type: UnificationXref
id: Q8BUN5
db: uniprot

Pcaf
type: Protein
entity reference: Pcaf
feature: COMPLEX PARTICIPANT BINDING FEATURE s442 sa458 351
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Insulin-2
type: ProteinReference
xref: uniprot P01326 49
organism: Mus musculus

STATE_TRANSITION_LEFT__IRS_1-RIGHT__AKT-_re452
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re452 956
participant stoichiometry: PARTICIPANT STOICHIOMETRY re452 957
left: IRS-1
interaction type: STATE_TRANSITION
right: AKT

UNKNOWN_TRANSITION_LEFT__IRS-RIGHT__ERK1_2-_re451
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re451 958
participant stoichiometry: PARTICIPANT STOICHIOMETRY re451 959
left: IRS
interaction type: UNKNOWN_TRANSITION
right: ERK1/2

SN
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s652 sa583 373
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

c-fos
type: RnaRegion
entity reference: c-fos
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

ERK1/2
type: Protein
entity reference: ERK1/2
feature: COMPLEX PARTICIPANT BINDING FEATURE s860 sa530 323
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

CGA
type: RnaRegion
entity reference: CGA
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

Voltage-dependent L-type calcium channel subunit alpha-1D
type: ProteinReference
xref: PTHR45628:SF11
xref: uniprot Q99246 58
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re660 618
type: Stoichiometry
physical entity: 5' LHbeta
stoichiometric coefficient: 1.0

uniprot Q02789 57
type: UnificationXref
id: Q02789
db: uniprot

PTHR10218:SF73
type: RelationshipXref
id: PTHR10218:SF73
db: PANTHER Family
relationship type: By Homology

gnas s536 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: gnas
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__SRC-RIGHT__Pyk2-_re476
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re476 927
participant stoichiometry: PARTICIPANT STOICHIOMETRY re476 926
left: SRC
interaction type: STATE_TRANSITION
right: Pyk2

BMPR-IA/IB/II
type: ProteinReference
xref: P06740
comment: ENTITY_REFERENCE_NOTES= Bmpr1a: GeneID: 12166; Bmpr1b: GeneID: 12167 ; Bmpr2: GeneID: 12168
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.BMPR-IA/IB/II
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Bone morphogenetic protein receptor type-1A
member entity reference: Bone morphogenetic protein receptor type-2
member entity reference: Bone morphogenetic protein receptor type-1B

PTHR24072:SF136
type: RelationshipXref
id: PTHR24072:SF136
db: PANTHER Family
relationship type: By Homology

PLCbeta
type: ProteinReference
xref: P06705
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PLCbeta
comment: ENTITY_REFERENCE_NOTES=Plcb1: GeneID: 18795
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

uniprot P63085 29
type: UnificationXref
id: P63085
db: uniprot

PARTICIPANT STOICHIOMETRY re660 617
type: Stoichiometry
physical entity: PITX
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__SF1-RIGHT__5_QUOTE_SINGLE_LHbeta-_re631
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re631 693
participant stoichiometry: PARTICIPANT STOICHIOMETRY re631 694
left: SF1
interaction type: STATE_TRANSITION
right: 5' LHbeta

ERE Fosb s440 sa455 tr1
type: BindingFeature
comment: MODIFICATION_REGION_POSITION=0.41
comment: MODIFICATION_REGION_NAME=ERE
comment: MODIFICATION_REGION_ACTIVATION=FALSE
comment: MODIFICATION_REGION_SIZE=0.12
comment: MODIFICATION_REGION_TYPE=RegulatoryRegion

TRANSCRIPTION
type: RelationshipTypeVocabulary

SMAD2 4 s571 sa180 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.39269908169872414

STATE_TRANSITION
type: Control
xref: STATE TRANSITION
controlled: Cell migration
controller: Cdc42_GTP

PARTICIPANT STOICHIOMETRY re461 950
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

MISRII s148 sa210 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MISRII
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re461 951
type: Stoichiometry
physical entity: 5' FSHbeta
stoichiometric coefficient: 1.0

uniprot Q80XI6 163
type: UnificationXref
id: Q80XI6
db: uniprot

Caveolin-1
type: Protein
entity reference: Caveolin-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s855 sa525 313
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR11849:SF178
type: RelationshipXref
id: PTHR11849:SF178
db: PANTHER Family
relationship type: By Homology

uniprot Q61839 6
type: UnificationXref
id: Q61839
db: uniprot

Mitogen-activated protein kinase kinase kinase 10
type: ProteinReference
xref: PTHR44329:SF39
xref: uniprot Q66L42 162
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re271 611
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re271 610
type: Stoichiometry
physical entity: MKK3/6
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__COX2-RIGHT__PGs-_re259
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re259 650
participant stoichiometry: PARTICIPANT STOICHIOMETRY re259 649
left: COX2
interaction type: STATE_TRANSITION
right: PGs

p300
type: Protein
entity reference: p300
feature: COMPLEX PARTICIPANT BINDING FEATURE s164 sa220 439
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Alk4_ActivinA_ActRII_IIB-RIGHT__TAK1-_re225
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re225 752
participant stoichiometry: PARTICIPANT STOICHIOMETRY re225 753
left: Alk4_ActivinA_ActRII/IIB
interaction type: STATE_TRANSITION
right: TAK1

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

PTHR11866:SF3
type: RelationshipXref
id: PTHR11866:SF3
db: PANTHER Family
relationship type: By Homology

uniprot Q9Z0S2 54
type: UnificationXref
id: Q9Z0S2
db: uniprot

PTHR11635:SF126
type: RelationshipXref
id: PTHR11635:SF126
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__SF1-RIGHT__5_QUOTE_SINGLE_LHbeta-_re639
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re639 679
participant stoichiometry: PARTICIPANT STOICHIOMETRY re639 680
left: SF1
interaction type: STATE_TRANSITION
right: 5' LHbeta

STATE_TRANSITION_LEFT__DAG-RIGHT__nPKCs-_re361
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re361 537
participant stoichiometry: PARTICIPANT STOICHIOMETRY re361 538
left: DAG
interaction type: STATE_TRANSITION
right: nPKCs

ncbitaxon 10090 7
type: UnificationXref
id: 10090
db: ncbitaxon

5'-AMP-activated protein kinase subunit beta-2
type: ProteinReference
xref: uniprot Q6PAM0 219
organism: Mus musculus

IP3
type: SmallMolecule
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSLATION_LEFT__RICS-RIGHT__RICS-_re535
control type: INHIBITION
controller: miR-132/212

STAT3
type: ProteinReference
xref: P06795
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Gene ID: 20848
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.STAT3
member entity reference: Signal transducer and activator of transcription 3

ActRII IIB s728 sa648 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ActRII/IIB
stoichiometric coefficient: 1.0

Prolactin receptor
type: ProteinReference
xref: uniprot Q08501 223
organism: Mus musculus

Adiponectin receptor protein 2
type: ProteinReference
xref: uniprot Q8BQS5 51
organism: Mus musculus

uniprot Q9JIW5 117
type: UnificationXref
id: Q9JIW5
db: uniprot

85/88 kDa calcium-independent phospholipase A2
type: ProteinReference
xref: uniprot P97819 232
organism: Mus musculus

gnas
type: ProteinReference
xref: P06717
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= GeneID: 14683 PMID: 12050161 Cell permeable peptide inhibitor blocked downstream responses and GnRH stimulated cAMP production and GTP loading.
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.gnas
member entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

PLD
type: ProteinReference
xref: P06839
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PLD
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Gpld1: GeneID: 14756
member entity reference: Phosphatidylinositol-glycan-specific phospholipase D

uniprot Q61083 160
type: UnificationXref
id: Q61083
db: uniprot

UNKNOWN_TRANSITION_LEFT__PKCs-RIGHT__Junc-_re298
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re298 570
participant stoichiometry: PARTICIPANT STOICHIOMETRY re298 569
left: PKCs
interaction type: UNKNOWN_TRANSITION
right: Junc

STATE_TRANSITION_LEFT__MAP4Ks-RIGHT__MAP3Ks-_re318
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re318 599
participant stoichiometry: PARTICIPANT STOICHIOMETRY re318 598
left: MAP4Ks
interaction type: STATE_TRANSITION
right: MAP3Ks

SRC s862 sa532 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Ca_CaMK_II-RIGHT__Caln-_re420
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re420 998
participant stoichiometry: PARTICIPANT STOICHIOMETRY re420 999
left: Ca/CaMK II
interaction type: STATE_TRANSITION
right: Caln

STATE_TRANSITION_LEFT__Alk4-RIGHT__PI3K-_re576
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re576 783
participant stoichiometry: PARTICIPANT STOICHIOMETRY re576 782
left: Alk4
interaction type: STATE_TRANSITION
right: PI3K

STATE_TRANSITION_LEFT__SMAD2_4_Pbx1_Prep1-RIGHT__3_QUOTE_SINGLE_FSHbeta-_re655
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re655 640
participant stoichiometry: PARTICIPANT STOICHIOMETRY re655 639
left: SMAD2-4_Pbx1_Prep1
interaction type: STATE_TRANSITION
right: 3' FSHbeta

Atrial natriuretic peptide receptor 2
type: ProteinReference
xref: uniprot Q6VVW5 45
organism: Mus musculus

sa5_degraded
type: PhysicalEntity
cellular location: Proteasome
comment: SPECIES_TYPE=DEGRADED

PARTICIPANT STOICHIOMETRY re320 585
type: Stoichiometry
physical entity: MAP3Ks
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase kinase kinase 4
type: ProteinReference
xref: uniprot P97820 17
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re320 586
type: Stoichiometry
physical entity: MKK4/7
stoichiometric coefficient: 1.0

Neuronal proto-oncogene tyrosine-protein kinase Src
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot P05480 172
organism: Mus musculus

uniprot Q811P8 179
type: UnificationXref
id: Q811P8
db: uniprot

STATE_TRANSITION_LEFT__AKT-RIGHT__SMAD2_4-_re302
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re302 616
participant stoichiometry: PARTICIPANT STOICHIOMETRY re302 615
left: AKT
interaction type: STATE_TRANSITION
right: SMAD2-4

FAK
type: Protein
entity reference: FAK
feature: COMPLEX PARTICIPANT BINDING FEATURE s871 sa700 463
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Lutropin subunit beta
type: DnaReference
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re418 1002
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

Guanylate cyclase soluble subunit beta-1
type: ProteinReference
xref: uniprot O54865 77
organism: Mus musculus

PG Rcs s630 sa561 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PG Rcs
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__CNP-_re459
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re459 952
participant stoichiometry: PARTICIPANT STOICHIOMETRY re459 953
left: Ca2+
interaction type: UNKNOWN_TRANSITION
right: CNP

p65 s887 sa555 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p65
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re418 1003
type: Stoichiometry
physical entity: 5' LHbeta
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__NOSI-_re345
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re345 547
participant stoichiometry: PARTICIPANT STOICHIOMETRY re345 548
left: Ca2+
interaction type: STATE_TRANSITION
right: NOSI

PACAP
type: RnaRegion
entity reference: PACAP
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

PKCs
type: ProteinReference
xref: P06733
comment: ENTITY_REFERENCE_NOTES=protein kinase C, alpha: GeneID: 18750 ; protein kinase C, beta: GeneID: 18751 ; protein kinase C, delta: GeneID: 18753 ; protein kinase C, epsilon: GeneID: 18754 ; protein kinase C, zeta: GeneID: 18762
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PKCs
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C alpha type
member entity reference: Protein kinase C delta type
member entity reference: Protein kinase C zeta type
member entity reference: Protein kinase C beta type

DNA-binding protein inhibitor ID-2
type: ProteinReference
xref: uniprot P41136 65
organism: Mus musculus

Glycoprotein hormones alpha chain
type: DnaReference
xref: PTHR11509:SF0
organism: Mus musculus

uniprot P08046 189
type: UnificationXref
id: P08046
db: uniprot

PARTICIPANT STOICHIOMETRY re475 928
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

TRANSLATION_LEFT__c_fos-RIGHT__FOS-_re546
type: TemplateReaction
product: FOS
xref: TRANSLATION
participant: FOS
participant: c-fos
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

PARTICIPANT STOICHIOMETRY re475 929
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PTHR24072:SF105
type: RelationshipXref
id: PTHR24072:SF105
db: PANTHER Family
relationship type: By Homology

Rap1b
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.Rap1b
comment: ENTITY_REFERENCE_NOTES=GeneID: 215449

Zeb1
type: Protein
entity reference: Zeb1
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re473 931
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re473 930
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__GC-RIGHT__cGMP-_re429
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re429 985
participant stoichiometry: PARTICIPANT STOICHIOMETRY re429 984
left: GC
interaction type: STATE_TRANSITION
right: cGMP

Solute carrier family 2, facilitated glucose transporter member 1
type: ProteinReference
xref: uniprot P17809 212
organism: Mus musculus

IRS s470 sa483 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IRS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re286 589
type: Stoichiometry
physical entity: IR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re363 534
type: Stoichiometry
physical entity: PLD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re363 533
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

Bone morphogenetic protein 7
type: DnaReference
xref: PTHR11848:SF135
organism: Mus musculus

uniprot P00405 190
type: UnificationXref
id: P00405
db: uniprot

uniprot O54865 77
type: UnificationXref
id: O54865
db: uniprot

Activin A homodimer
type: Complex
component stoichiometry: Inhba s730 sa649 STOICHIOMETRY ID COMPLEX
component: Inhba
feature: COMPLEX PARTICIPANT BINDING FEATURE s729 csa31 273
feature: COMPLEX BINDING FEATURE s729 csa31 270
cellular location: Cytoplasm

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__MKK3_6-RIGHT__p38-_re271
control type: INHIBITION
controller: PPARgamma

alpha beta integrin dimer s786 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha-beta integrin dimer
stoichiometric coefficient: 2.0

CNP
type: Protein
entity reference: CNP
feature: COMPLEX PARTICIPANT BINDING FEATURE s434 sa450 267
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

TORC1 s748 sa670 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TORC1
stoichiometric coefficient: 1.0

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

MEK1 2 s874 sa703 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MEK1/2
stoichiometric coefficient: 1.0

Nur77
type: DnaRegionReference
member entity reference: Nuclear receptor subfamily 4 group A member 1
xref: G06893
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.Nur77
comment: ENTITY_REFERENCE_NOTES=GeneID: 15370

uniprot Q61127 134
type: UnificationXref
id: Q61127
db: uniprot

Junc
type: RnaRegion
entity reference: Junc
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

PTHR45628:SF11
type: RelationshipXref
id: PTHR45628:SF11
db: PANTHER Family
relationship type: By Homology

Annexin A5
type: DnaReference
organism: Mus musculus

PTHR45628:SF10
type: RelationshipXref
id: PTHR45628:SF10
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re549 858
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__?-RIGHT__3_QUOTE_SINGLE_LHbeta-_re633
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re633 690
participant stoichiometry: PARTICIPANT STOICHIOMETRY re633 689
left: ?
interaction type: STATE_TRANSITION
right: 3' LHbeta

PARTICIPANT STOICHIOMETRY re549 859
type: Stoichiometry
physical entity: SKIL
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re445 965
type: Stoichiometry
physical entity: PR
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__?-RIGHT__3_QUOTE_SINGLE_LHbeta-_re634
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re634 688
participant stoichiometry: PARTICIPANT STOICHIOMETRY re634 687
left: ?
interaction type: STATE_TRANSITION
right: 3' LHbeta

Npr2
type: ProteinReference
xref: P06796
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.Npr2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
comment: ENTITY_REFERENCE_NOTES= GeneID: 230103
member entity reference: Atrial natriuretic peptide receptor 2

PARTICIPANT STOICHIOMETRY re588 740
type: Stoichiometry
physical entity: Caln
stoichiometric coefficient: 1.0

TBRIII
type: ProteinReference
xref: P06806
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.TBRIII
comment: ENTITY_REFERENCE_NOTES=GeneID: 21814
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Transforming growth factor beta receptor type 3

PARTICIPANT STOICHIOMETRY re445 964
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

ECM
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s787 sa360 389
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re588 741
type: Stoichiometry
physical entity: TORC1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re599 695
type: Stoichiometry
physical entity: CTNNB1_TCF
stoichiometric coefficient: 1.0

uniprot Q9QVP9 173
type: UnificationXref
id: Q9QVP9
db: uniprot

PARTICIPANT STOICHIOMETRY re18 830
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re599 696
type: Stoichiometry
physical entity: Junc
stoichiometric coefficient: 1.0

EIF2AK3
type: Complex
component stoichiometry: EIF2AK3 s217 sa271 STOICHIOMETRY ID COMPLEX
component: EIF2AK3
cellular location: Endoplasmic Reticulum

PARTICIPANT STOICHIOMETRY re337 558
type: Stoichiometry
physical entity: LTs
stoichiometric coefficient: 1.0

CTNNB1 s396 sa410 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CTNNB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re337 557
type: Stoichiometry
physical entity: 12-LO
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CLIM2-RIGHT__LHX2-_re412
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re412 1007
participant stoichiometry: PARTICIPANT STOICHIOMETRY re412 1006
left: CLIM2
interaction type: STATE_TRANSITION
right: LHX2

STATE_TRANSITION_LEFT__alpha_beta_integrin_dimer-RIGHT__Pyk2_SRC_Grb2_Sos-_re479
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re479 922
participant stoichiometry: PARTICIPANT STOICHIOMETRY re479 923
left: alpha-beta integrin dimer
interaction type: STATE_TRANSITION
right: Pyk2_SRC_Grb2_Sos

5' LHbeta
type: DnaRegion
entity reference: 5' LHbeta
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

PARTICIPANT STOICHIOMETRY re286 590
type: Stoichiometry
physical entity: EGR1
stoichiometric coefficient: 1.0

GTP s669 sa601 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Tubulin
type: ProteinReference
xref: P06772
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= tubulin, alpha 1A: GeneID: 22142; tubulin, alpha 1B: GeneID: 22143; tubulin, alpha 1C: GeneID: 22146
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Tubulin
member entity reference: Tubulin alpha-1A chain
member entity reference: Tubulin alpha-1C chain
member entity reference: Tubulin alpha-1B chain

DNA-binding protein inhibitor ID-3
type: ProteinReference
xref: uniprot P41133 64
organism: Mus musculus

RFRP 1 3 s734 sa653 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RFRP-1/-3
stoichiometric coefficient: 1.0

uniprot P70227 93
type: UnificationXref
id: P70227
db: uniprot

PARTICIPANT STOICHIOMETRY re452 957
type: Stoichiometry
physical entity: AKT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re452 956
type: Stoichiometry
physical entity: IRS-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re610 776
type: Stoichiometry
physical entity: NFAT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re610 777
type: Stoichiometry
physical entity: Nur77
stoichiometric coefficient: 1.0

CRE NOSI s526 sa536 tr1
type: BindingFeature
comment: MODIFICATION_REGION_ACTIVATION=FALSE
comment: MODIFICATION_REGION_POSITION=0.21999999999999997
comment: MODIFICATION_REGION_SIZE=0.16
comment: MODIFICATION_REGION_NAME=CRE
comment: MODIFICATION_REGION_TYPE=RegulatoryRegion

uniprot P42227 79
type: UnificationXref
id: P42227
db: uniprot

Vinculin
type: ProteinReference
xref: P06771
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= GeneID: 22330
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Vinculin
member entity reference: Vinculin

STATE_TRANSITION_LEFT__SRF-RIGHT__c_fos-_re609
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re609 806
participant stoichiometry: PARTICIPANT STOICHIOMETRY re609 805
left: SRF
interaction type: STATE_TRANSITION
right: c-fos

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: uniprot Q8CE90 171
xref: PTHR48013:SF17
organism: Mus musculus

uniprot P12849 188
type: UnificationXref
id: P12849
db: uniprot

SMAD_PITX_OTX
type: Complex
component stoichiometry: SMAD2 4 s683 sa339 STOICHIOMETRY ID COMPLEX
component stoichiometry: PITX s385 sa404 STOICHIOMETRY ID COMPLEX
component stoichiometry: OTX s291 sa341 STOICHIOMETRY ID COMPLEX
component: OTX
component: SMAD2-4
component: PITX
feature: COMPLEX BINDING FEATURE s762 csa11 508
feature: COMPLEX BINDING FEATURE s762 csa11 510
feature: COMPLEX BINDING FEATURE s762 csa11 512
cellular location: Nucleus

Prostaglandin E2 receptor EP1 subtype
type: ProteinReference
xref: uniprot P35375 144
xref: PTHR11866:SF3
organism: Mus musculus

PACAP
type: DnaRegionReference
member entity reference: Pituitary adenylate cyclase-activating polypeptide
xref: G06879
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.PACAP
comment: ENTITY_REFERENCE_NOTES=GeneID: 11516

PARTICIPANT STOICHIOMETRY re18 829
type: Stoichiometry
physical entity: PLCbeta
stoichiometric coefficient: 1.0

DRD2 s19 sa397 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DRD2
stoichiometric coefficient: 1.0

Jund s481 sa507 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Jund
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__GnRHR-RIGHT__AK006051-_re542
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re542 867
participant stoichiometry: PARTICIPANT STOICHIOMETRY re542 866
left: GnRHR
interaction type: UNKNOWN_TRANSITION
right: AK006051

TORC1
type: Protein
entity reference: TORC1
feature: COMPLEX PARTICIPANT BINDING FEATURE s748 sa670 265
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PKA-RIGHT__5_QUOTE_SINGLE_FSHbeta-_re417
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re417 1004
participant stoichiometry: PARTICIPANT STOICHIOMETRY re417 1005
left: PKA
interaction type: STATE_TRANSITION
right: 5' FSHbeta

Isl-1
type: DnaRegionReference
member entity reference: Insulin gene enhancer protein ISL-1
xref: G06896
comment: ENTITY_REFERENCE_NOTES=Gene ID: 16392
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.Isl-1

uniprot P12813 66
type: UnificationXref
id: P12813
db: uniprot

P06745
type: UnificationXref
id: P06745
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re602 816
type: Stoichiometry
physical entity: Scg2
stoichiometric coefficient: 1.0

P06746
type: UnificationXref
id: P06746
db: PANTHER Pathway Component

P06743
type: UnificationXref
id: P06743
db: PANTHER Pathway Component

P06744
type: UnificationXref
id: P06744
db: PANTHER Pathway Component

P06741
type: UnificationXref
id: P06741
db: PANTHER Pathway Component

P06742
type: UnificationXref
id: P06742
db: PANTHER Pathway Component

MAP2K1/2
type: ProteinReference
xref: P06794
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.MAP2K1/2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Map2k1: GeneID: 26395; Map2k2: GeneID: 26396
member entity reference: Dual specificity mitogen-activated protein kinase kinase 1
member entity reference: Dual specificity mitogen-activated protein kinase kinase 2

P06740
type: UnificationXref
id: P06740
db: PANTHER Pathway Component

Bone morphogenetic protein 7
type: ProteinReference
xref: PTHR11848:SF135
xref: uniprot P23359 61
organism: Mus musculus

Zinc finger E-box-binding homeobox 1
type: DnaReference
organism: Mus musculus

PTHR24356:SF170
type: RelationshipXref
id: PTHR24356:SF170
db: PANTHER Family
relationship type: By Homology

P06739
type: UnificationXref
id: P06739
db: PANTHER Pathway Component

Gbeta s619 sa552 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

AK006051
type: DnaRegion
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

P06738
type: UnificationXref
id: P06738
db: PANTHER Pathway Component

RFRP-1/-3
type: ProteinReference
xref: P06828
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.RFRP-1/-3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= GeneID: 60531
member entity reference: Pro-FMRFamide-related neuropeptide VF

P06737
type: UnificationXref
id: P06737
db: PANTHER Pathway Component

P06736
type: UnificationXref
id: P06736
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re22 798
type: Stoichiometry
physical entity: PLCbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re22 797
type: Stoichiometry
physical entity: gnaq/11
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re389 995
type: Stoichiometry
physical entity: Junc
stoichiometric coefficient: 1.0

Rap1b
type: RnaRegion
entity reference: Rap1b
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re389 994
type: Stoichiometry
physical entity: JNK1/2
stoichiometric coefficient: 1.0

uniprot P31938 42
type: UnificationXref
id: P31938
db: uniprot

alpha-beta integrin dimer
type: Protein
entity reference: alpha-beta integrin dimer

EGFR s53 sa99 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 1.0

NGFI-A-binding protein 2
type: ProteinReference
xref: uniprot Q61127 134
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re571 793
type: Stoichiometry
physical entity: Activin A homodimer
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Caln-RIGHT__NFAT-_re577
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re577 778
participant stoichiometry: PARTICIPANT STOICHIOMETRY re577 779
left: Caln
interaction type: STATE_TRANSITION
right: NFAT

PTHR23220:SF22
type: RelationshipXref
id: PTHR23220:SF22
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Caln-RIGHT__NFAT-_re578
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re578 774
participant stoichiometry: PARTICIPANT STOICHIOMETRY re578 775
left: Caln
interaction type: STATE_TRANSITION
right: NFAT

SF1 s832 sa689 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re571 794
type: Stoichiometry
physical entity: ActRII/IIB
stoichiometric coefficient: 1.0

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot P63001 225
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re209 819
type: Stoichiometry
physical entity: Alk4_ActivinA_ActRII/IIB
stoichiometric coefficient: 1.0

P06732
type: UnificationXref
id: P06732
db: PANTHER Pathway Component

DGK-zeta
type: Protein
entity reference: DGK-zeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s336 sa346 363
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

P06733
type: UnificationXref
id: P06733
db: PANTHER Pathway Component

P06734
type: UnificationXref
id: P06734
db: PANTHER Pathway Component

P06735
type: UnificationXref
id: P06735
db: PANTHER Pathway Component

UNKNOWN_TRANSITION_LEFT__NFAT-RIGHT__Junc-_re584
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re584 755
participant stoichiometry: PARTICIPANT STOICHIOMETRY re584 754
left: NFAT
interaction type: UNKNOWN_TRANSITION
right: Junc

P06730
type: UnificationXref
id: P06730
db: PANTHER Pathway Component

P06731
type: UnificationXref
id: P06731
db: PANTHER Pathway Component

PACAP_PAC1-R_gnas
type: Complex
component stoichiometry: PAC1 R s283 sa334 STOICHIOMETRY ID COMPLEX
component stoichiometry: PACAP s260 sa321 STOICHIOMETRY ID COMPLEX
component stoichiometry: gnas s606 sa366 STOICHIOMETRY ID COMPLEX
component: PACAP
component: gnas
component: PAC1-R
feature: COMPLEX BINDING FEATURE s777 csa46 290
feature: COMPLEX BINDING FEATURE s777 csa46 294
feature: COMPLEX BINDING FEATURE s777 csa46 292
cellular location: Cytoplasm

PARTICIPANT STOICHIOMETRY re347 543
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

P06729
type: UnificationXref
id: P06729
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re658 633
type: Stoichiometry
physical entity: Junc
stoichiometric coefficient: 1.0

Sos
type: Protein
entity reference: Sos
feature: COMPLEX PARTICIPANT BINDING FEATURE s497 sa514 411
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re658 634
type: Stoichiometry
physical entity: CGA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re347 544
type: Stoichiometry
physical entity: L-type Ca2+
stoichiometric coefficient: 1.0

TORC1
type: Protein
entity reference: TORC1
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

P06726
type: UnificationXref
id: P06726
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re602 815
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

P06725
type: UnificationXref
id: P06725
db: PANTHER Pathway Component

P06728
type: UnificationXref
id: P06728
db: PANTHER Pathway Component

PTHR24356:SF181
type: RelationshipXref
id: PTHR24356:SF181
db: PANTHER Family
relationship type: By Homology

P06727
type: UnificationXref
id: P06727
db: PANTHER Pathway Component

UNKNOWN_INHIBITION
type: TemplateReactionRegulation
xref: UNKNOWN INHIBITION
controlled: TRANSCRIPTION_LEFT__BMP7-RIGHT__BMP7-_re554
control type: INHIBITION
controller: GnRH

PARTICIPANT STOICHIOMETRY re209 820
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

Rac1 s616 sa549 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rac1
stoichiometric coefficient: 1.0

Zinc finger E-box-binding homeobox 1
type: ProteinReference
xref: uniprot Q64318 186
organism: Mus musculus

MISRII
type: ProteinReference
xref: P06792
comment: ENTITY_REFERENCE_NOTES= GeneID: 110542
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.MISRII
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Anti-Muellerian hormone type-2 receptor

P06760
type: UnificationXref
id: P06760
db: PANTHER Pathway Component

ActRII s688 sa618 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ActRII
stoichiometric coefficient: 1.0

45 kDa calcium-binding protein
type: ProteinReference
xref: uniprot Q61112 218
organism: Mus musculus

P06763
type: UnificationXref
id: P06763
db: PANTHER Pathway Component

MKK3/6
type: ProteinReference
xref: P06805
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=MKK3: GeneID: 26397; MKK6: GeneID: 26399
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.MKK3/6
member entity reference: Dual specificity mitogen-activated protein kinase kinase 3
member entity reference: Dual specificity mitogen-activated protein kinase kinase 6

P06764
type: UnificationXref
id: P06764
db: PANTHER Pathway Component

P06761
type: UnificationXref
id: P06761
db: PANTHER Pathway Component

P06762
type: UnificationXref
id: P06762
db: PANTHER Pathway Component

uniprot Q9WV60 166
type: UnificationXref
id: Q9WV60
db: uniprot

BMPR IA IB II s191 sa213 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMPR-IA/IB/II
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot P62874 192
organism: Mus musculus

P06768
type: UnificationXref
id: P06768
db: PANTHER Pathway Component

GnRHR
type: Protein
entity reference: GnRHR
feature: COMPLEX PARTICIPANT BINDING FEATURE s878 sa707 477
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

P06765
type: UnificationXref
id: P06765
db: PANTHER Pathway Component

P06766
type: UnificationXref
id: P06766
db: PANTHER Pathway Component

Vinculin
type: ProteinReference
xref: uniprot Q64727 34
xref: PTHR46180:SF1
organism: Mus musculus

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: PTHR19850:SF36
xref: uniprot P62881 194
organism: Mus musculus

P06759
type: UnificationXref
id: P06759
db: PANTHER Pathway Component

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: PTHR19850:SF27
xref: uniprot P62880 193
organism: Mus musculus

uniprot Q04997 205
type: UnificationXref
id: Q04997
db: uniprot

P06758
type: UnificationXref
id: P06758
db: PANTHER Pathway Component

Steroid hormone receptor ERR1
type: ProteinReference
xref: uniprot O08580 108
organism: Mus musculus

GnRH
type: Protein
entity reference: GnRH
comment: SPECIES_TYPE=PROTEIN

gnas
type: Protein
entity reference: gnas
feature: COMPLEX PARTICIPANT BINDING FEATURE s606 sa366 295
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

TRANSCRIPTION_LEFT__NOSI-RIGHT__NOSI-_re499
type: TemplateReaction
product: NOSI
xref: TRANSCRIPTION
participant: NOSI
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PTHR24356:SF193
type: RelationshipXref
id: PTHR24356:SF193
db: PANTHER Family
relationship type: By Homology

MIS
type: Protein
entity reference: MIS
feature: COMPLEX PARTICIPANT BINDING FEATURE s199 sa258 433
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

NGFI-A-binding protein 1
type: ProteinReference
xref: uniprot Q61122 133
organism: Mus musculus

Mitogen-activated protein kinase kinase kinase kinase 5
type: ProteinReference
xref: PTHR48012:SF19
xref: uniprot Q8BPM2 19
organism: Mus musculus

P06750
type: UnificationXref
id: P06750
db: PANTHER Pathway Component

Insulin gene enhancer protein ISL-1
type: DnaReference
organism: Mus musculus

P06751
type: UnificationXref
id: P06751
db: PANTHER Pathway Component

P06752
type: UnificationXref
id: P06752
db: PANTHER Pathway Component

P06753
type: UnificationXref
id: P06753
db: PANTHER Pathway Component

P06754
type: UnificationXref
id: P06754
db: PANTHER Pathway Component

P06755
type: UnificationXref
id: P06755
db: PANTHER Pathway Component

P06756
type: UnificationXref
id: P06756
db: PANTHER Pathway Component

c-Raf
type: ProteinReference
xref: P06832
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.c-Raf
comment: ENTITY_REFERENCE_NOTES=GeneID: 110157
member entity reference: RAF proto-oncogene serine/threonine-protein kinase

P06757
type: UnificationXref
id: P06757
db: PANTHER Pathway Component

GTP s845 sa683 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

P06747
type: UnificationXref
id: P06747
db: PANTHER Pathway Component

P06749
type: UnificationXref
id: P06749
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re605 812
type: Stoichiometry
physical entity: COX2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re469 940
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re605 811
type: Stoichiometry
physical entity: p65_p65
stoichiometric coefficient: 1.0

uniprot P47809 170
type: UnificationXref
id: P47809
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
control type: INHIBITION
controller: PPARgamma

DGK-zeta
type: ProteinReference
xref: P06790
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.DGK-zeta
comment: ENTITY_REFERENCE_NOTES= GeneID: 104418
member entity reference: Diacylglycerol kinase zeta

PARTICIPANT STOICHIOMETRY re469 941
type: Stoichiometry
physical entity: ER
stoichiometric coefficient: 1.0

Atf3
type: DnaRegionReference
member entity reference: Cyclic AMP-dependent transcription factor ATF-3
xref: G06902
comment: ENTITY_REFERENCE_NOTES=GeneID: 11910
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.Atf3

FOS_JUN
type: Complex
component stoichiometry: JUN s479 sa505 STOICHIOMETRY ID COMPLEX
component stoichiometry: FOS s599 sa506 STOICHIOMETRY ID COMPLEX
component: FOS
component: JUN
feature: COMPLEX BINDING FEATURE s826 csa66 330
feature: COMPLEX BINDING FEATURE s826 csa66 328
cellular location: Nucleus

Muellerian-inhibiting factor
type: ProteinReference
xref: uniprot P27106 80
organism: Mus musculus

P06789
type: UnificationXref
id: P06789
db: PANTHER Pathway Component

P06788
type: UnificationXref
id: P06788
db: PANTHER Pathway Component

P06787
type: UnificationXref
id: P06787
db: PANTHER Pathway Component

P06786
type: UnificationXref
id: P06786
db: PANTHER Pathway Component

P06785
type: UnificationXref
id: P06785
db: PANTHER Pathway Component

P06784
type: UnificationXref
id: P06784
db: PANTHER Pathway Component

P06783
type: UnificationXref
id: P06783
db: PANTHER Pathway Component

P06782
type: UnificationXref
id: P06782
db: PANTHER Pathway Component

P06781
type: UnificationXref
id: P06781
db: PANTHER Pathway Component

P06780
type: UnificationXref
id: P06780
db: PANTHER Pathway Component

UNKNOWN_TRANSITION
type: Control
xref: UNKNOWN TRANSITION
controlled: LH secretion
controller: DRD2

Calmodulin regulator protein PCP4
type: ProteinReference
xref: uniprot P63054 155
organism: Mus musculus

ncbitaxon 9606 40
type: UnificationXref
id: 9606
db: ncbitaxon

CTNNB1
type: Protein
entity reference: CTNNB1
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

TRANSLATION_LEFT__Junc-RIGHT__Junc-_re400
type: TemplateReaction
product: Junc
xref: TRANSLATION
participant: Junc
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

SMAD3_Id2_Id3
type: Complex
component stoichiometry: Id3 s633 sa564 STOICHIOMETRY ID COMPLEX
component stoichiometry: Id2 s632 sa563 STOICHIOMETRY ID COMPLEX
component stoichiometry: SMAD2 4 s684 sa233 STOICHIOMETRY ID COMPLEX
component: Id3
component: Id2
component: SMAD2-4
feature: COMPLEX BINDING FEATURE s757 csa22 494
feature: COMPLEX BINDING FEATURE s757 csa22 498
feature: COMPLEX BINDING FEATURE s757 csa22 496
cellular location: Nucleus

uniprot Q8CE90 171
type: UnificationXref
id: Q8CE90
db: uniprot

TRANSLATION_LEFT__NOSI-RIGHT__NOSI-_re500
type: TemplateReaction
product: NOSI
xref: TRANSLATION
participant: NOSI
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

P06777
type: UnificationXref
id: P06777
db: PANTHER Pathway Component

Proteasome
type: CellularLocationVocabulary
xref: go GO:0000502 2

P06779
type: UnificationXref
id: P06779
db: PANTHER Pathway Component

P06778
type: UnificationXref
id: P06778
db: PANTHER Pathway Component

TRANSCRIPTION_LEFT__GnRHR-RIGHT__GnRHR-_re513
type: TemplateReaction
product: GnRHR
xref: TRANSCRIPTION
participant: GnRHR
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PARTICIPANT STOICHIOMETRY re655 640
type: Stoichiometry
physical entity: 3' FSHbeta
stoichiometric coefficient: 1.0

P06773
type: UnificationXref
id: P06773
db: PANTHER Pathway Component

P06772
type: UnificationXref
id: P06772
db: PANTHER Pathway Component

P06774
type: UnificationXref
id: P06774
db: PANTHER Pathway Component

BMP6/7
type: ProteinReference
xref: P06752
comment: ENTITY_REFERENCE_NOTES= BMP6: GeneID: 12161; BMP7: GeneID: 12162
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.BMP6/7
member entity reference: Bone morphogenetic protein 6
member entity reference: Bone morphogenetic protein 7

P06771
type: UnificationXref
id: P06771
db: PANTHER Pathway Component

Ggamma
type: ProteinReference
xref: P06754
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= GeneID: 14702
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Ggamma
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

D(2) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF87
xref: uniprot P61168 245
organism: Mus musculus

c-fos
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.c-fos
comment: ENTITY_REFERENCE_NOTES=GeneID: 14281

STATE_TRANSITION_LEFT__PITX-RIGHT__5_QUOTE_SINGLE_LHbeta-_re660
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re660 617
participant stoichiometry: PARTICIPANT STOICHIOMETRY re660 618
left: PITX
interaction type: STATE_TRANSITION
right: 5' LHbeta

MEK1/2
type: ProteinReference
xref: P06739
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.MEK1/2
comment: ENTITY_REFERENCE_NOTES=MEK1: GeneID: 26395 ; MEK2: GeneID: 26396
member entity reference: Dual specificity mitogen-activated protein kinase kinase 1
member entity reference: Dual specificity mitogen-activated protein kinase kinase 2

PARTICIPANT STOICHIOMETRY re462 949
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re462 948
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__AdipoR1_R2-RIGHT__AMPK-_re136
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re136 880
participant stoichiometry: PARTICIPANT STOICHIOMETRY re136 881
left: AdipoR1/R2
interaction type: STATE_TRANSITION
right: AMPK

STATE_TRANSITION_LEFT__ActRII_IIB-RIGHT__Activin_A_homodimer-_re572
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re572 792
participant stoichiometry: PARTICIPANT STOICHIOMETRY re572 791
left: ActRII/IIB
interaction type: STATE_TRANSITION
right: Activin A homodimer

P06769
type: UnificationXref
id: P06769
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re315 602
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re315 603
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

FOS s824 sa508 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re362 535
type: Stoichiometry
physical entity: gnas
stoichiometric coefficient: 1.0

Mothers against decapentaplegic homolog 5
type: ProteinReference
xref: PTHR13703:SF36
xref: uniprot P97454 113
organism: Mus musculus

PKCe/theta
type: ProteinReference
xref: P06798
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=PKC epsilon: GeneID: 18754; PKC theta: GeneID: 18761
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PKCe/theta
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C theta type

PARTICIPANT STOICHIOMETRY re362 536
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

PTHR24356:SF159
type: RelationshipXref
id: PTHR24356:SF159
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF158
type: RelationshipXref
id: PTHR24356:SF158
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__SMAD2_4-RIGHT__3_QUOTE_SINGLE_FSHbeta-_re656
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re656 637
participant stoichiometry: PARTICIPANT STOICHIOMETRY re656 638
left: SMAD2-4
interaction type: STATE_TRANSITION
right: 3' FSHbeta

uniprot P08752 210
type: UnificationXref
id: P08752
db: uniprot

Rac1_GTP
type: Complex
component stoichiometry: Rac1 s616 sa549 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s669 sa601 STOICHIOMETRY ID COMPLEX
component: Rac1
component: GTP
feature: COMPLEX BINDING FEATURE s842 csa71 504
feature: COMPLEX BINDING FEATURE s842 csa71 506
cellular location: Cytoplasm

AMPK
type: Protein
entity reference: AMPK
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

UNKNOWN_TRANSITION_LEFT__5_HT3AR-RIGHT__3_QUOTE_SINGLE_LHbeta-_re170
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re170 803
participant stoichiometry: PARTICIPANT STOICHIOMETRY re170 804
left: 5-HT3AR
interaction type: UNKNOWN_TRANSITION
right: 3' LHbeta

uniprot Q01815 56
type: UnificationXref
id: Q01815
db: uniprot

Pituitary adenylate cyclase-activating polypeptide
type: DnaReference
organism: Mus musculus

AKT
type: ProteinReference
xref: P06779
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.AKT
comment: ENTITY_REFERENCE_NOTES=GeneID: 11651
member entity reference: RAC-alpha serine/threonine-protein kinase

SRC
type: Protein
entity reference: SRC
feature: COMPLEX PARTICIPANT BINDING FEATURE s499 sa348 365
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

P06795
type: UnificationXref
id: P06795
db: PANTHER Pathway Component

P06794
type: UnificationXref
id: P06794
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__PKCs-RIGHT__EGR1-_re467
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re467 942
participant stoichiometry: PARTICIPANT STOICHIOMETRY re467 943
left: PKCs
interaction type: STATE_TRANSITION
right: EGR1

P06797
type: UnificationXref
id: P06797
db: PANTHER Pathway Component

P06796
type: UnificationXref
id: P06796
db: PANTHER Pathway Component

P06799
type: UnificationXref
id: P06799
db: PANTHER Pathway Component

UNKNOWN_TRANSITION_LEFT__BMPR_IA_IB_II-RIGHT__5_QUOTE_SINGLE_FSHbeta-_re217
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re217 781
participant stoichiometry: PARTICIPANT STOICHIOMETRY re217 780
left: BMPR-IA/IB/II
interaction type: UNKNOWN_TRANSITION
right: 5' FSHbeta

P06798
type: UnificationXref
id: P06798
db: PANTHER Pathway Component

uniprot Q80UP3 110
type: UnificationXref
id: Q80UP3
db: uniprot

IP3R
type: Protein
entity reference: IP3R
cellular location: Endoplasmic Reticulum
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase kinase kinase 2
type: ProteinReference
xref: uniprot Q61161 18
organism: Mus musculus

SF1
type: Protein
entity reference: SF1
feature: COMPLEX PARTICIPANT BINDING FEATURE s836 sa691 447
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

MEK1 2 s859 sa529 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MEK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re346 545
type: Stoichiometry
physical entity: NOSI
stoichiometric coefficient: 1.0

P06791
type: UnificationXref
id: P06791
db: PANTHER Pathway Component

CGA
type: RnaRegionReference
comment: ENTITY_REFERENCE_NOTES=GeneID: 12640
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.CGA

OCT-1
type: Protein
entity reference: OCT-1
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re346 546
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 1.0

P06790
type: UnificationXref
id: P06790
db: PANTHER Pathway Component

P06793
type: UnificationXref
id: P06793
db: PANTHER Pathway Component

P06792
type: UnificationXref
id: P06792
db: PANTHER Pathway Component

PTHR23351:SF4
type: RelationshipXref
id: PTHR23351:SF4
db: PANTHER Family
relationship type: By Homology

BMP2/4/15
type: ProteinReference
xref: P06817
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= BMP2: GeneID: 12156; BMP4: GeneID: 12159; BMP15: GeneID: 12155
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.BMP2/4/15
member entity reference: Bone morphogenetic protein 4
member entity reference: Bone morphogenetic protein 15
member entity reference: Bone morphogenetic protein 2

PRLR
type: Protein
entity reference: PRLR
feature: COMPLEX PARTICIPANT BINDING FEATURE s381 sa396 377
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re359 540
type: Stoichiometry
physical entity: SF1
stoichiometric coefficient: 1.0

SN_Unknown GPCR
type: Complex
component stoichiometry: SN s652 sa583 STOICHIOMETRY ID COMPLEX
component stoichiometry: Unknown GPCR s651 sa582 STOICHIOMETRY ID COMPLEX
component: SN
component: Unknown GPCR
feature: COMPLEX BINDING FEATURE s780 csa49 372
feature: COMPLEX BINDING FEATURE s780 csa49 370
cellular location: Cytoplasm

HETERODIMER_ASSOCIATION_LEFT__TORC1-_Nur77-RIGHT__Nur77_TORC1-_re590
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re590 710
participant stoichiometry: PARTICIPANT STOICHIOMETRY re590 709
participant stoichiometry: PARTICIPANT STOICHIOMETRY re590 711
left: Nur77
left: TORC1
interaction type: HETERODIMER_ASSOCIATION
right: Nur77_TORC1

STATE_TRANSITION_LEFT__PKA-RIGHT__ATF2-_CREB-_re243
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re243 676
participant stoichiometry: PARTICIPANT STOICHIOMETRY re243 677
participant stoichiometry: PARTICIPANT STOICHIOMETRY re243 678
left: PKA
interaction type: STATE_TRANSITION
right: CREB
right: ATF2

GC
type: Protein
entity reference: GC
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re611 772
type: Stoichiometry
physical entity: STAT3
stoichiometric coefficient: 1.0

GnRHR
type: Protein
entity reference: GnRHR
feature: COMPLEX PARTICIPANT BINDING FEATURE s863 sa519 305
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q07174 156
type: UnificationXref
id: Q07174
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PEA_15-RIGHT__PEA_15-_re532
controller: PKCs

TRANSLATION_LEFT__COX2-RIGHT__COX2-_re274
type: TemplateReaction
product: COX2
xref: TRANSLATION
participant: COX2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

IP3R
type: ProteinReference
xref: P06768
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.ION_CHANNEL.IP3R
comment: ENTITY_REFERENCE_NOTES=Itpr1: GeneID: 16438 ; Itpr2: GeneID: 16439 ; Itpr3: GeneID: 16440
member entity reference: Inositol 1,4,5-trisphosphate receptor type 2
member entity reference: Inositol 1,4,5-trisphosphate receptor type 3
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1

PARTICIPANT STOICHIOMETRY re611 773
type: Stoichiometry
physical entity: Isl-1
stoichiometric coefficient: 1.0

SMAD1 5 8 s690 sa620 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.39269908169872414

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re263
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re263 628
participant stoichiometry: PARTICIPANT STOICHIOMETRY re263 627
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

STATE_TRANSITION_LEFT__SNURF-RIGHT__SF1-_re173
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re173 802
participant stoichiometry: PARTICIPANT STOICHIOMETRY re173 801
left: SNURF
interaction type: STATE_TRANSITION
right: SF1

Cap-dependent translation
type: Pathway

Pituitary homeobox 2
type: ProteinReference
xref: uniprot P97474 204
organism: Mus musculus

UNKNOWN_TRANSITION_LEFT__p38-RIGHT__Follistatin-_re323
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re323 581
participant stoichiometry: PARTICIPANT STOICHIOMETRY re323 582
left: p38
interaction type: UNKNOWN_TRANSITION
right: Follistatin

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SMAD2_4-RIGHT__SMAD2_4-_re551
controller: Alk4_ActivinA_ActRII/IIB

Mothers against decapentaplegic homolog 4
type: ProteinReference
xref: PTHR13703:SF45
xref: uniprot P97471 114
organism: Mus musculus

Inhba s730 sa649 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Inhba
stoichiometric coefficient: 2.0

Inhba s713 sa642 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Inhba
stoichiometric coefficient: 2.0

INHIBITION
type: Control
xref: INHIBITION
controlled: TRANSPORT_LEFT__ERK1_2-RIGHT__ERK1_2-_re113
control type: INHIBITION
controller: PEA-15

Zeb1 s323 sa246 tr1
type: BindingFeature
comment: MODIFICATION_REGION_ACTIVATION=FALSE
comment: MODIFICATION_REGION_POSITION=0.18294117647058822
comment: MODIFICATION_REGION_NAME=
comment: MODIFICATION_REGION_SIZE=0.14
comment: MODIFICATION_REGION_TYPE=RegulatoryRegion

FSHbeta
type: ProteinReference
xref: P06809
comment: ENTITY_REFERENCE_NOTES=GeneID: 14308
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.FSHbeta
member entity reference: Follitropin subunit beta

EGR1
type: ProteinReference
xref: P06837
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.EGR1
comment: ENTITY_REFERENCE_NOTES=GeneID: 13653
member entity reference: Early growth response protein 1

SF1
type: ProteinReference
xref: P06848
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.SF1
comment: ENTITY_REFERENCE_NOTES=GeneID: 26423
member entity reference: Steroidogenic factor 1

PARTICIPANT STOICHIOMETRY re495 883
type: Stoichiometry
physical entity: COX2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re495 882
type: Stoichiometry
physical entity: JNK1/2
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase kinase 9
type: ProteinReference
xref: uniprot Q3U1V8 158
organism: Mus musculus

TGFbeta
type: Protein
entity reference: TGFbeta
comment: SPECIES_TYPE=PROTEIN

Prostaglandin E2 receptor EP3 subtype
type: ProteinReference
xref: PTHR11866:SF10
xref: uniprot P30557 142
organism: Mus musculus

Atf3
type: DnaRegion
entity reference: Atf3
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

Integrin alpha-1
type: ProteinReference
xref: PTHR23220:SF22
xref: uniprot Q3V3R4 137
organism: Mus musculus

gnai s735 sa654 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: gnai
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re261 630
type: Stoichiometry
physical entity: PLA2
stoichiometric coefficient: 1.0

NF-Y
type: Protein
entity reference: NF-Y
feature: COMPLEX PARTICIPANT BINDING FEATURE s310 sa202 345
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05627 227
organism: Mus musculus

TRANSLATION_LEFT__EGR1-RIGHT__EGR1-_re289
type: TemplateReaction
product: EGR1
xref: TRANSLATION
participant: EGR1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

PTHR24361:SF342
type: RelationshipXref
id: PTHR24361:SF342
db: PANTHER Family
relationship type: By Homology

uniprot Q60687 242
type: UnificationXref
id: Q60687
db: uniprot

Gonadotropin-releasing hormone receptor
type: ProteinReference
xref: PTHR24241:SF22
xref: uniprot Q01776 151
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re344 549
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

p38
type: ProteinReference
xref: P06831
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.p38
comment: ENTITY_REFERENCE_NOTES=p38-alpha: GeneID: 26416 ; p38-beta: GeneID: 19094 ; p38-gamma: GeneID: 29857 ; p38-delta: GeneID: 26415
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase 12

uniprot Q9Z1B3 88
type: UnificationXref
id: Q9Z1B3
db: uniprot

uniprot Q01147 185
type: UnificationXref
id: Q01147
db: uniprot

CRE Follistatin s251 sa314 tr1
type: BindingFeature
comment: MODIFICATION_REGION_ACTIVATION=FALSE
comment: MODIFICATION_REGION_SIZE=0.16
comment: MODIFICATION_REGION_NAME=CRE
comment: MODIFICATION_REGION_TYPE=RegulatoryRegion
comment: MODIFICATION_REGION_POSITION=0.42

NF-Y
type: Protein
entity reference: NF-Y
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot Q9DC51 211
organism: Mus musculus

TRANSCRIPTION_LEFT__c_fos-RIGHT__c_fos-_re545
type: TemplateReaction
product: c-fos
xref: TRANSCRIPTION
participant: c-fos
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PARTICIPANT STOICHIOMETRY re616 762
type: Stoichiometry
physical entity: NF-Y
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re616 763
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

Ras s861 sa531 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

ActRII IIB s726 sa643 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ActRII/IIB
stoichiometric coefficient: 1.0

uniprot P62881 194
type: UnificationXref
id: P62881
db: uniprot

uniprot P97305 105
type: UnificationXref
id: P97305
db: uniprot

BMP7
type: DnaRegionReference
member entity reference: Bone morphogenetic protein 7
xref: G06901
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.BMP7
comment: ENTITY_REFERENCE_NOTES=GeneID: 12162

UNKNOWN_TRANSITION_LEFT__GnRHR-RIGHT__PLD-_re363
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re363 534
participant stoichiometry: PARTICIPANT STOICHIOMETRY re363 533
left: GnRHR
interaction type: UNKNOWN_TRANSITION
right: PLD

Csda
type: Protein
entity reference: Csda
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Junc
type: Protein
entity reference: Junc
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: uniprot P12849 188
xref: PTHR11635:SF126
organism: Mus musculus

SP3 s478 sa500 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SP3
stoichiometric coefficient: 1.0

PTHR24169:SF1
type: RelationshipXref
id: PTHR24169:SF1
db: PANTHER Family
relationship type: By Homology

ERK1/2
type: ProteinReference
xref: P06786
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.ERK1/2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=ERK1: GeneID: 26417 ; ERK2: GeneID: 26413
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase 1

PARTICIPANT STOICHIOMETRY re399 968
type: Stoichiometry
physical entity: CTNNB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re399 969
type: Stoichiometry
physical entity: CTNNB1_TCF
stoichiometric coefficient: 1.0

SMAD2-4
type: Protein
entity reference: SMAD2-4
feature: COMPLEX PARTICIPANT BINDING FEATURE s595 sa342 449
feature: SMAD2 4 s595 sa342 rs1
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Rac1
type: Protein
entity reference: Rac1
feature: COMPLEX PARTICIPANT BINDING FEATURE s660 sa592 283
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

DRD2
type: Protein
entity reference: DRD2
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa397 337
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re561 835
type: Stoichiometry
physical entity: 3' LHbeta
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Atf3-RIGHT__CGA-_re659
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re659 631
participant stoichiometry: PARTICIPANT STOICHIOMETRY re659 632
left: Atf3
interaction type: STATE_TRANSITION
right: CGA

PARTICIPANT STOICHIOMETRY re561 834
type: Stoichiometry
physical entity: PKCe/theta
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

Resveratrol
type: SmallMolecule
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Nur77
type: Protein
entity reference: Nur77
feature: COMPLEX PARTICIPANT BINDING FEATURE s745 sa667 521
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

TRANSLATION_LEFT__Glut1-RIGHT__Glut1-_re565
type: TemplateReaction
product: Glut1
xref: TRANSLATION
participant: Glut1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

PARTICIPANT STOICHIOMETRY re643 668
type: Stoichiometry
physical entity: mPer1
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__ERK1_2-RIGHT__SF1-_re359
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re359 539
participant stoichiometry: PARTICIPANT STOICHIOMETRY re359 540
left: ERK1/2
interaction type: UNKNOWN_TRANSITION
right: SF1

Mitogen-activated protein kinase kinase kinase 13
type: ProteinReference
xref: uniprot Q1HKZ5 157
organism: Mus musculus

Rap1b
type: ProteinReference
xref: P06803
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 215449
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Rap1b
member entity reference: Ras-related protein Rap-1b

uniprot Q04206 39
type: UnificationXref
id: Q04206
db: uniprot

Pcaf_ER
type: Complex
component stoichiometry: ER s609 sa464 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pcaf s442 sa458 STOICHIOMETRY ID COMPLEX
component: Pcaf
component: ER
feature: COMPLEX BINDING FEATURE s751 csa14 352
feature: COMPLEX BINDING FEATURE s751 csa14 350
cellular location: Nucleus

PARTICIPANT STOICHIOMETRY re344 550
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re643 667
type: Stoichiometry
physical entity: EGR1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re420 999
type: Stoichiometry
physical entity: Caln
stoichiometric coefficient: 1.0

Inhba
type: Protein
entity reference: Inhba
feature: COMPLEX PARTICIPANT BINDING FEATURE s713 sa642 515
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re420 998
type: Stoichiometry
physical entity: Ca/CaMK II
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CBP-RIGHT__CBP-_re586
controller: PKCs

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSLATION_LEFT__EGR1-RIGHT__EGR1-_re289
control type: ACTIVATION
controller: EGR1_Csda

HETERODIMER_ASSOCIATION_LEFT__Activin_A_homodimer-_Alk4-RIGHT__Activin_A_homodimer-_re575
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re575 786
participant stoichiometry: PARTICIPANT STOICHIOMETRY re575 788
participant stoichiometry: PARTICIPANT STOICHIOMETRY re575 787
left: Alk4
left: Activin A homodimer
interaction type: HETERODIMER_ASSOCIATION
right: Activin A homodimer

By Homology
type: RelationshipTypeVocabulary

GnRH s804 sa682 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GnRH
stoichiometric coefficient: 1.0

Catenin beta-1
type: ProteinReference
xref: uniprot Q02248 83
xref: PTHR45976:SF4
organism: Mus musculus

Nitric oxide synthase, brain
type: DnaReference
organism: Mus musculus

PTHR10336:SF12
type: RelationshipXref
id: PTHR10336:SF12
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Pyk2_SRC_Grb2_Sos-RIGHT__Ras-_re12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 839
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 838
left: Pyk2_SRC_Grb2_Sos
interaction type: STATE_TRANSITION
right: Ras

STATE_TRANSITION_LEFT__PLCbeta-RIGHT__IP3-_re251
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re251 653
participant stoichiometry: PARTICIPANT STOICHIOMETRY re251 654
left: PLCbeta
interaction type: STATE_TRANSITION
right: IP3

PARTICIPANT STOICHIOMETRY re261 629
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

C-type natriuretic peptide
type: DnaReference
organism: Mus musculus

uniprot P97471 114
type: UnificationXref
id: P97471
db: uniprot

STATE_TRANSITION_LEFT__gnaq_11-RIGHT__PLCbeta-_re22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 798
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 797
left: gnaq/11
interaction type: STATE_TRANSITION
right: PLCbeta

CNP
type: RnaRegion
entity reference: CNP
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

PARTICIPANT STOICHIOMETRY re412 1007
type: Stoichiometry
physical entity: LHX2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re412 1006
type: Stoichiometry
physical entity: CLIM2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re559 840
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re645 664
type: Stoichiometry
physical entity: CGA
stoichiometric coefficient: 1.0

Calcium/calmodulin-dependent protein kinase type II subunit beta
type: ProteinReference
xref: uniprot P28652 202
xref: PTHR24347:SF403
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re559 841
type: Stoichiometry
physical entity: 5' LHbeta
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__STAT3-RIGHT__Isl_1-_re611
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re611 773
participant stoichiometry: PARTICIPANT STOICHIOMETRY re611 772
left: STAT3
interaction type: STATE_TRANSITION
right: Isl-1

PARTICIPANT STOICHIOMETRY re645 663
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription 3
type: ProteinReference
xref: uniprot P42227 79
xref: PTHR11801:SF2
organism: Mus musculus

STATE_TRANSITION_LEFT__Nur77_TORC1-RIGHT__3_QUOTE_SINGLE_FSHbeta-_re654
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re654 642
participant stoichiometry: PARTICIPANT STOICHIOMETRY re654 641
left: Nur77_TORC1
interaction type: STATE_TRANSITION
right: 3' FSHbeta

PARTICIPANT STOICHIOMETRY re359 539
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

Nur77
type: Protein
entity reference: Nur77
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot O08911 84
organism: Mus musculus

Cyclic AMP-responsive element-binding protein 1
type: ProteinReference
xref: uniprot Q01147 185
xref: PTHR45879:SF1
organism: Mus musculus

uniprot Q9Z1J1 71
type: UnificationXref
id: Q9Z1J1
db: uniprot

GATA2/4
type: Protein
entity reference: GATA2/4
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Zeb1
type: ProteinReference
xref: P06783
comment: ENTITY_REFERENCE_NOTES=GeneID: 21417 PMID:17823254 This shows that overexpression of Zfhx1a (Zeb1) decreases regulation of the LHb promoter. This connection is weak as the study does not explore knockdown of endogenous Zfhx1a by siRNA.
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Zeb1
member entity reference: Zinc finger E-box-binding homeobox 1

Pre-B-cell leukemia transcription factor 1
type: ProteinReference
xref: uniprot P41778 62
organism: Mus musculus

uniprot Q02067 196
type: UnificationXref
id: Q02067
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot O09110 31
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re425 990
type: Stoichiometry
physical entity: MAP2K1/2
stoichiometric coefficient: 1.0

uniprot P43117 145
type: UnificationXref
id: P43117
db: uniprot

Zeb1
type: RnaRegion
entity reference: Zeb1
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

PARTICIPANT STOICHIOMETRY re425 991
type: Stoichiometry
physical entity: MEK1/2
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION_LEFT__MKK4_7-RIGHT__JNK1_2-_re321
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re321 584
participant stoichiometry: PARTICIPANT STOICHIOMETRY re321 583
left: MKK4/7
interaction type: STATE_TRANSITION
right: JNK1/2

uniprot P97454 113
type: UnificationXref
id: P97454
db: uniprot

PARTICIPANT STOICHIOMETRY re640 674
type: Stoichiometry
physical entity: CTNNB1_SF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re640 675
type: Stoichiometry
physical entity: 5' LHbeta
stoichiometric coefficient: 1.0

EGFR
type: ProteinReference
xref: P06843
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.EGFR
comment: ENTITY_REFERENCE_NOTES= GeneID: 13649
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Epidermal growth factor receptor

Cell Survival
type: Pathway

PARTICIPANT STOICHIOMETRY re633 690
type: Stoichiometry
physical entity: 3' LHbeta
stoichiometric coefficient: 1.0

Follistatin
type: ProteinReference
xref: P06835
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Follistatin
comment: ENTITY_REFERENCE_NOTES=GeneID: 14313
member entity reference: Follistatin

PTHR23255:SF22
type: RelationshipXref
id: PTHR23255:SF22
db: PANTHER Family
relationship type: By Homology

CNP s434 sa450 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CNP
stoichiometric coefficient: 1.0

SRC
type: ProteinReference
xref: P06844
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.SRC
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 20779
member entity reference: Neuronal proto-oncogene tyrosine-protein kinase Src

PTHR24055:SF222
type: RelationshipXref
id: PTHR24055:SF222
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__AR-RIGHT__GnRHR-_re615
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re615 765
participant stoichiometry: PARTICIPANT STOICHIOMETRY re615 764
left: AR
interaction type: STATE_TRANSITION
right: GnRHR

Nuclear receptor subfamily 4 group A member 1
type: ProteinReference
xref: uniprot P12813 66
organism: Mus musculus

Pbx1
type: ProteinReference
xref: P06729
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= GeneID: 18514 PMID:14764653 It shows that pbx1 binds to FSHb promoter and mutation at pbx1 binding site totally abrogates the induction of FSHb promoter activity by activin. It shows that pbx1 form complex with smads and prep1.
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Pbx1
member entity reference: Pre-B-cell leukemia transcription factor 1

Rho GTPase-activating protein 32
type: DnaReference
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re459 952
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re459 953
type: Stoichiometry
physical entity: CNP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re340 553
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re340 554
type: Stoichiometry
physical entity: PA
stoichiometric coefficient: 1.0

gnas s606 sa366 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: gnas
stoichiometric coefficient: 1.0

SMAD1/5/8
type: Protein
entity reference: SMAD1/5/8
feature: SMAD1 5 8 s689 sa619 rs1
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR23113:SF168
type: RelationshipXref
id: PTHR23113:SF168
db: PANTHER Family
relationship type: By Homology

uniprot Q61097 222
type: UnificationXref
id: Q61097
db: uniprot

TORC1
type: Protein
entity reference: TORC1
feature: COMPLEX PARTICIPANT BINDING FEATURE s744 sa668 523
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot P11881 92
xref: PTHR13715:SF52
organism: Mus musculus

uniprot P23708 9
type: UnificationXref
id: P23708
db: uniprot

PARTICIPANT STOICHIOMETRY re633 689
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__NFAT-RIGHT__Atf3-_re585
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re585 751
participant stoichiometry: PARTICIPANT STOICHIOMETRY re585 750
left: NFAT
interaction type: UNKNOWN_TRANSITION
right: Atf3

KSR 1 s872 sa701 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: KSR-1
stoichiometric coefficient: 1.0

Ncoa3_PR
type: Complex
component stoichiometry: PR s487 sa236 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ncoa3 s459 sa479 STOICHIOMETRY ID COMPLEX
component: Ncoa3
component: PR
feature: COMPLEX BINDING FEATURE s756 csa16 278
feature: COMPLEX BINDING FEATURE s756 csa16 280
cellular location: Nucleus

Csda
type: Protein
entity reference: Csda
feature: COMPLEX PARTICIPANT BINDING FEATURE s698 sa630 525
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Id2
type: Protein
entity reference: Id2
feature: COMPLEX PARTICIPANT BINDING FEATURE s632 sa563 497
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

GnRH
type: Protein
entity reference: GnRH
feature: COMPLEX PARTICIPANT BINDING FEATURE s811 sa680 249
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__TAK1-RIGHT__p38-_re229
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re229 738
participant stoichiometry: PARTICIPANT STOICHIOMETRY re229 739
left: TAK1
interaction type: STATE_TRANSITION
right: p38

SF1 s836 sa691 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SF1
stoichiometric coefficient: 1.0

Nucleus
type: CellularLocationVocabulary
xref: go GO:0005634 4

uniprot Q8K120 107
type: UnificationXref
id: Q8K120
db: uniprot

uniprot O08580 108
type: UnificationXref
id: O08580
db: uniprot

Sos s497 sa514 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Sos
stoichiometric coefficient: 1.0

uniprot Q9WTU6 126
type: UnificationXref
id: Q9WTU6
db: uniprot

Pyk2 s494 sa512 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pyk2
stoichiometric coefficient: 1.0

Cyclic AMP-dependent transcription factor ATF-3
type: DnaReference
xref: PTHR23351:SF23
organism: Mus musculus

SKIL
type: Protein
entity reference: SKIL
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

PACAP
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.PACAP
comment: ENTITY_REFERENCE_NOTES=GeneID: 11516

PARTICIPANT STOICHIOMETRY re622 733
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

Arachidonate 15-lipoxygenase
type: ProteinReference
xref: PTHR11771:SF33
xref: uniprot P39654 76
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re477 925
type: Stoichiometry
physical entity: alpha-beta integrin dimer
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re477 924
type: Stoichiometry
physical entity: Pyk2
stoichiometric coefficient: 1.0

PPARalpha/gamma
type: ProteinReference
xref: P06744
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=PPARalpha: GeneID: 19013 ; PPARgamma: GeneID: 19016
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PPARalpha/gamma
member entity reference: Peroxisome proliferator-activated receptor alpha
member entity reference: Peroxisome proliferator-activated receptor gamma

Endothelial transcription factor GATA-2
type: ProteinReference
xref: uniprot O09100 118
organism: Mus musculus

TRANSPORT_LEFT__ERK1_2-RIGHT__ERK1_2-_re485
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re485 909
participant stoichiometry: PARTICIPANT STOICHIOMETRY re485 908
left: ERK1/2
interaction type: TRANSPORT
right: ERK1/2

Cell proliferation
type: Pathway

G06896
type: UnificationXref
id: G06896
db: PANTHER Pathway Component

G06897
type: UnificationXref
id: G06897
db: PANTHER Pathway Component

uniprot P41133 64
type: UnificationXref
id: P41133
db: uniprot

G06898
type: UnificationXref
id: G06898
db: PANTHER Pathway Component

G06899
type: UnificationXref
id: G06899
db: PANTHER Pathway Component

Lutropin subunit beta
type: ProteinReference
xref: uniprot O09108 135
organism: Mus musculus

go GO:0000502 2
type: UnificationXref
id: GO:0000502
db: go

G06892
type: UnificationXref
id: G06892
db: PANTHER Pathway Component

G06893
type: UnificationXref
id: G06893
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re622 732
type: Stoichiometry
physical entity: SF1
stoichiometric coefficient: 1.0

G06894
type: UnificationXref
id: G06894
db: PANTHER Pathway Component

UNKNOWN_TRANSITION_LEFT__Alk4_ActivinA_ActRII_IIB-RIGHT__CGA-_re504
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re504 937
participant stoichiometry: PARTICIPANT STOICHIOMETRY re504 936
left: Alk4_ActivinA_ActRII/IIB
interaction type: UNKNOWN_TRANSITION
right: CGA

G06895
type: UnificationXref
id: G06895
db: PANTHER Pathway Component

Zeb1
type: DnaRegionReference
member entity reference: Zinc finger E-box-binding homeobox 1
xref: G06884
comment: ENTITY_REFERENCE_NOTES=GeneID: 21417
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.Zeb1

Nur77
type: RnaRegion
entity reference: Nur77
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

OTX
type: ProteinReference
xref: P06818
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Otx1: GeneID: 18423 PMID: 15961509 PMID: 12040015
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.OTX
member entity reference: Homeobox protein OTX1

UNKNOWN_TRANSITION_LEFT__Unknown_GPCR-RIGHT__PKCs-_re530
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re530 875
participant stoichiometry: PARTICIPANT STOICHIOMETRY re530 874
left: Unknown GPCR
interaction type: UNKNOWN_TRANSITION
right: PKCs

uniprot B2RSH2 209
type: UnificationXref
id: B2RSH2
db: uniprot

PTHR23255:SF64
type: RelationshipXref
id: PTHR23255:SF64
db: PANTHER Family
relationship type: By Homology

Jund
type: ProteinReference
xref: P06764
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Jund
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= GeneID: 16478
member entity reference: Transcription factor jun-D

uniprot Q8BXH3 78
type: UnificationXref
id: Q8BXH3
db: uniprot

TRANSCRIPTION_LEFT__Follistatin-RIGHT__Follistatin-_re309
type: TemplateReaction
product: Follistatin
xref: TRANSCRIPTION
participant: Follistatin
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PTHR23255:SF62
type: RelationshipXref
id: PTHR23255:SF62
db: PANTHER Family
relationship type: By Homology

GTPase HRas
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot Q61411 200
organism: Mus musculus

GnRH_GnRHR
type: Complex
component stoichiometry: GnRHR s803 sa681 STOICHIOMETRY ID COMPLEX
component stoichiometry: GnRH s804 sa682 STOICHIOMETRY ID COMPLEX
component: GnRHR
component: GnRH
feature: COMPLEX BINDING FEATURE s809 csa58 254
feature: COMPLEX BINDING FEATURE s809 csa58 256
feature: COMPLEX PARTICIPANT BINDING FEATURE s809 csa58 259
cellular location: Cytoplasm

PTHR23255:SF63
type: RelationshipXref
id: PTHR23255:SF63
db: PANTHER Family
relationship type: By Homology

GnRH s850 sa256 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GnRH
stoichiometric coefficient: 1.0

Annexin A5
type: DnaRegionReference
member entity reference: Annexin A5
xref: G06897
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.Annexin A5
comment: ENTITY_REFERENCE_NOTES=GeneID: 11747

PARTICIPANT STOICHIOMETRY re229 738
type: Stoichiometry
physical entity: TAK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re463 947
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re229 739
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

AMPK
type: ProteinReference
xref: P06830
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.AMPK
comment: ENTITY_REFERENCE_NOTES=protein kinase, AMP-activated, alpha 1 catalytic subunit: GeneID: 105787 ; protein kinase, AMP-activated, alpha 2 catalytic subunit: GeneID: 108079; protein kinase, AMP-activated, beta 1 non-catalytic subunit: GeneID: 19079 ; protein kinase, AMP-activated, beta 2 non-catalytic subunit: GeneID: 108097; protein kinase, AMP-activated, gamma 1 non-catalytic subunit: GeneID: 19082; protein kinase, AMP-activated, gamma 2 non-catalytic subunit: GeneID: 108099
member entity reference: 5'-AMP-activated protein kinase subunit beta-1
member entity reference: 5'-AMP-activated protein kinase subunit gamma-2
member entity reference: 5'-AMP-activated protein kinase subunit beta-2
member entity reference: 5'-AMP-activated protein kinase catalytic subunit alpha-1
member entity reference: 45 kDa calcium-binding protein
member entity reference: 5'-AMP-activated protein kinase subunit gamma-1

PARTICIPANT STOICHIOMETRY re463 946
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

TRANSCRIPTION
type: InteractionVocabulary

UNKNOWN_TRANSITION
type: Control
xref: UNKNOWN TRANSITION
controlled: Cell proliferation
controller: ERK1/2

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot B2RSH2 209
xref: PTHR10218:SF227
organism: Mus musculus

PTHR12533:SF6
type: RelationshipXref
id: PTHR12533:SF6
db: PANTHER Family
relationship type: By Homology

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P20444 25
organism: Mus musculus

PTHR11801:SF2
type: RelationshipXref
id: PTHR11801:SF2
db: PANTHER Family
relationship type: By Homology

PTHR23255:SF70
type: RelationshipXref
id: PTHR23255:SF70
db: PANTHER Family
relationship type: By Homology

PACAP s260 sa321 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PACAP
stoichiometric coefficient: 1.0

Follitropin subunit beta
type: DnaReference
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re447 960
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re632 691
type: Stoichiometry
physical entity: SP1
stoichiometric coefficient: 1.0

Follistatin
type: DnaReference
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re632 692
type: Stoichiometry
physical entity: 5' LHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re447 961
type: Stoichiometry
physical entity: AKT
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SMAD1_5_8-RIGHT__SMAD1_5_8-_re552
controller: ActRII

Anti-Muellerian hormone type-2 receptor
type: ProteinReference
xref: uniprot Q8K592 109
xref: PTHR23255:SF49
organism: Mus musculus

Prolactin
type: ProteinReference
xref: P06789
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= GeneID: 19109
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Prolactin
member entity reference: Prolactin

STATE_TRANSITION_LEFT__CTNNB1_SF1-RIGHT__5_QUOTE_SINGLE_LHbeta-_re640
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re640 675
participant stoichiometry: PARTICIPANT STOICHIOMETRY re640 674
left: CTNNB1_SF1
interaction type: STATE_TRANSITION
right: 5' LHbeta

uniprot Q9WUL6 164
type: UnificationXref
id: Q9WUL6
db: uniprot

PTHR13715:SF52
type: RelationshipXref
id: PTHR13715:SF52
db: PANTHER Family
relationship type: By Homology

PTHR13715:SF51
type: RelationshipXref
id: PTHR13715:SF51
db: PANTHER Family
relationship type: By Homology

Linoleate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR13715:SF53
type: RelationshipXref
id: PTHR13715:SF53
db: PANTHER Family
relationship type: By Homology

uniprot Q62073 150
type: UnificationXref
id: Q62073
db: uniprot

Mitogen-activated protein kinase kinase kinase 8
type: ProteinReference
xref: uniprot Q07174 156
xref: PTHR48016:SF31
organism: Mus musculus

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: uniprot Q9WV60 166
xref: PTHR24057:SF8
organism: Mus musculus

uniprot Q61011 195
type: UnificationXref
id: Q61011
db: uniprot

PARTICIPANT STOICHIOMETRY re275 609
type: Stoichiometry
physical entity: EGR1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re275 608
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PEA_15-RIGHT__PEA_15-_re532
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re532 870
participant stoichiometry: PARTICIPANT STOICHIOMETRY re532 871
left: PEA-15
interaction type: STATE_TRANSITION
right: PEA-15

TRANSPORT_LEFT__CTNNB1-RIGHT__CTNNB1-_re641
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re641 673
participant stoichiometry: PARTICIPANT STOICHIOMETRY re641 672
left: CTNNB1
interaction type: TRANSPORT
right: CTNNB1

Protein fosB
type: DnaReference
organism: Mus musculus

FOS
type: Protein
entity reference: FOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s150 sa203 347
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Proto-oncogene c-Fos
type: DnaReference
xref: PTHR23351:SF4
organism: Mus musculus

uniprot P17809 212
type: UnificationXref
id: P17809
db: uniprot

STATE_TRANSITION_LEFT__PKCs-RIGHT__ER-_re470
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re470 935
participant stoichiometry: PARTICIPANT STOICHIOMETRY re470 934
left: PKCs
interaction type: STATE_TRANSITION
right: ER

STATE_TRANSITION_LEFT__CREB-RIGHT__Scg2-_re602
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re602 815
participant stoichiometry: PARTICIPANT STOICHIOMETRY re602 816
left: CREB
interaction type: STATE_TRANSITION
right: Scg2

uniprot P63139 10
type: UnificationXref
id: P63139
db: uniprot

Syt IV
type: Protein
entity reference: Syt IV
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR23255:SF49
type: RelationshipXref
id: PTHR23255:SF49
db: PANTHER Family
relationship type: By Homology

p65
type: Protein
entity reference: p65
feature: COMPLEX PARTICIPANT BINDING FEATURE s887 sa555 419
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re587 744
type: Stoichiometry
physical entity: CBP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re587 745
type: Stoichiometry
physical entity: EGR1
stoichiometric coefficient: 1.0

LTs
type: SmallMolecule
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR23255:SF50
type: RelationshipXref
id: PTHR23255:SF50
db: PANTHER Family
relationship type: By Homology

MIS s199 sa258 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MIS
stoichiometric coefficient: 1.0

PPARgamma
type: Protein
entity reference: PPARgamma
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

TRANSCRIPTION_LEFT__Fosb-RIGHT__Fosb-_re436
type: TemplateReaction
product: Fosb
xref: TRANSCRIPTION
participant: Fosb
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Mitogen-activated protein kinase kinase kinase 11
type: ProteinReference
xref: uniprot Q80XI6 163
organism: Mus musculus

TRANSCRIPTION_LEFT__PACAP-RIGHT__PACAP-_re515
type: TemplateReaction
product: PACAP
xref: TRANSCRIPTION
participant: PACAP
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

CLIM2
type: ProteinReference
xref: P06736
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.CLIM2
comment: ENTITY_REFERENCE_NOTES=GeneID: 16825
member entity reference: LIM domain-binding protein 1

UNKNOWN_INHIBITION
type: RelationshipTypeVocabulary

TRANSCRIPTION_LEFT__CGA-RIGHT__CGA-_re413
type: TemplateReaction
product: CGA
xref: TRANSCRIPTION
participant: CGA
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot P25425 63
type: UnificationXref
id: P25425
db: uniprot

STATE_TRANSITION_LEFT__Ca_CaMK_II-RIGHT__5_QUOTE_SINGLE_LHbeta-_re390
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re390 983
participant stoichiometry: PARTICIPANT STOICHIOMETRY re390 982
left: Ca/CaMK II
interaction type: STATE_TRANSITION
right: 5' LHbeta

TRANSCRIPTION_LEFT__BMP7-RIGHT__BMP7-_re554
type: TemplateReaction
product: BMP7
xref: TRANSCRIPTION
participant: BMP7
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

IR s192 sa177 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re585 751
type: Stoichiometry
physical entity: Atf3
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CREB-RIGHT__CGA-_re645
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re645 663
participant stoichiometry: PARTICIPANT STOICHIOMETRY re645 664
left: CREB
interaction type: STATE_TRANSITION
right: CGA

Nur77
type: ProteinReference
xref: P06713
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 15370 PMID: 19858197 Using live cell imaging, pulsatile GnRH caused dose- and frequency-dependent increases in nuclear NFAT2-emerald fluorescent protein, and at low frequency, translocation simply tracked GnRH exposure. GnRH also caused dose- and frequency-dependent activation of alphaGSU, luteinizing hormone beta, and follicle-stimulating hormone beta luciferase reporters, effects that were blocked by calcineurin inhibition. PMID: 21986493 Calcineurin mediates the gonadotropin-releasing hormone effect on expression of both subunits of the follicle-stimulating hormone through distinct mechanisms.
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Nur77
member entity reference: Nuclear receptor subfamily 4 group A member 1

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s669 sa601 507
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re629 719
type: Stoichiometry
physical entity: 5' LHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re629 718
type: Stoichiometry
physical entity: Junc
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re551 852
type: Stoichiometry
physical entity: SMAD2-4
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63085 29
organism: Mus musculus

KSR-1
type: ProteinReference
xref: P06842
comment: ENTITY_REFERENCE_NOTES= GeneID: 16706
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.KSR-1
member entity reference: Kinase suppressor of Ras 1

PARTICIPANT STOICHIOMETRY re551 853
type: Stoichiometry
physical entity: SMAD2-4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re585 750
type: Stoichiometry
physical entity: NFAT
stoichiometric coefficient: 1.0

uniprot Q08501 223
type: UnificationXref
id: Q08501
db: uniprot

Insulin_IR_IRS-1
type: Complex
component stoichiometry: IR s192 sa177 STOICHIOMETRY ID COMPLEX
component stoichiometry: IRS 1 s471 sa488 STOICHIOMETRY ID COMPLEX
component stoichiometry: Insulin s193 sa252 STOICHIOMETRY ID COMPLEX
component: Insulin
component: IRS-1
component: IR
feature: COMPLEX BINDING FEATURE s767 csa38 414
feature: COMPLEX BINDING FEATURE s767 csa38 412
feature: COMPLEX BINDING FEATURE s767 csa38 416
cellular location: Cytoplasm

uniprot P13346 97
type: UnificationXref
id: P13346
db: uniprot

SMAD2-4
type: ProteinReference
xref: P06819
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Smad2: GeneID: 17126; Smad3: GeneID: 17127; Smad4: GeneID: 17128
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.SMAD2-4
member entity reference: Mothers against decapentaplegic homolog 1
member entity reference: Mothers against decapentaplegic homolog 2
member entity reference: Mothers against decapentaplegic homolog 9
member entity reference: Mothers against decapentaplegic homolog 3
member entity reference: Mothers against decapentaplegic homolog 5
member entity reference: Mothers against decapentaplegic homolog 4

uniprot Q61112 218
type: UnificationXref
id: Q61112
db: uniprot

PARTICIPANT STOICHIOMETRY re345 548
type: Stoichiometry
physical entity: NOSI
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re621 737
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re621 736
type: Stoichiometry
physical entity: Junc
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__CTNNB1-_SF1-RIGHT__CTNNB1_SF1-_re642
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re642 669
participant stoichiometry: PARTICIPANT STOICHIOMETRY re642 671
participant stoichiometry: PARTICIPANT STOICHIOMETRY re642 670
left: CTNNB1
left: SF1
interaction type: HETERODIMER_ASSOCIATION
right: CTNNB1_SF1

PARTICIPANT STOICHIOMETRY re345 547
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__GnRHR-RIGHT__SRC-_re463
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re463 946
participant stoichiometry: PARTICIPANT STOICHIOMETRY re463 947
left: GnRHR
interaction type: UNKNOWN_TRANSITION
right: SRC

p65_p65
type: Complex
component stoichiometry: p65 s887 sa555 STOICHIOMETRY ID COMPLEX
component: p65
feature: COMPLEX BINDING FEATURE s886 csa62 418
cellular location: Nucleus

UNKNOWN_TRANSITION_LEFT__GnRHR-RIGHT__SRC-_re462
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re462 948
participant stoichiometry: PARTICIPANT STOICHIOMETRY re462 949
left: GnRHR
interaction type: UNKNOWN_TRANSITION
right: SRC

STATE_TRANSITION_LEFT__TBRIII-RIGHT__Inhba_b-_re442
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re442 966
participant stoichiometry: PARTICIPANT STOICHIOMETRY re442 967
left: TBRIII
interaction type: STATE_TRANSITION
right: Inhba/b

p38
type: Protein
entity reference: p38
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR10614:SF2
type: RelationshipXref
id: PTHR10614:SF2
db: PANTHER Family
relationship type: By Homology

MEK1/2
type: Protein
entity reference: MEK1/2
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re388 996
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re388 997
type: Stoichiometry
physical entity: 3' FSHbeta
stoichiometric coefficient: 1.0

PTHR10614:SF8
type: RelationshipXref
id: PTHR10614:SF8
db: PANTHER Family
relationship type: By Homology

FSHbeta
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.FSHbeta
comment: ENTITY_REFERENCE_NOTES=GeneID: 14308

PARTICIPANT STOICHIOMETRY re548 861
type: Stoichiometry
physical entity: ELK1
stoichiometric coefficient: 1.0

EIF2AK3
type: ProteinReference
xref: P06813
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.EIF2AK3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 13666
member entity reference: Eukaryotic translation initiation factor 2-alpha kinase 3

Son of sevenless homolog 1
type: ProteinReference
xref: uniprot Q62245 37
xref: PTHR23113:SF168
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re548 860
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

AdipoR1/R2
type: ProteinReference
xref: P06706
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.AdipoR1/R2
comment: ENTITY_REFERENCE_NOTES= Adipor1: GeneID: 72674 ; Adipor2: GeneID: 68465
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Adiponectin receptor protein 1
member entity reference: Adiponectin receptor protein 2

PARTICIPANT STOICHIOMETRY re532 870
type: Stoichiometry
physical entity: PEA-15
stoichiometric coefficient: 1.0

uniprot Q9JKB3 67
type: UnificationXref
id: Q9JKB3
db: uniprot

PARTICIPANT STOICHIOMETRY re532 871
type: Stoichiometry
physical entity: PEA-15
stoichiometric coefficient: 1.0

PR
type: Protein
entity reference: PR
feature: COMPLEX PARTICIPANT BINDING FEATURE s487 sa236 279
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

SMAD2-4
type: Protein
entity reference: SMAD2-4
feature: SMAD2 4 s571 sa180 rs1
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Insulin
type: ProteinReference
xref: P06793
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Insulin
comment: ENTITY_REFERENCE_NOTES= GeneID: 16334
member entity reference: Insulin-2

ActRII/IIB
type: Protein
entity reference: ActRII/IIB
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PEA-15
type: ProteinReference
xref: P06853
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Gene ID: 18611
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PEA-15
member entity reference: Astrocytic phosphoprotein PEA-15

PARTICIPANT STOICHIOMETRY re299 567
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re299 568
type: Stoichiometry
physical entity: Annexin A5
stoichiometric coefficient: 1.0

uniprot P48036 75
type: UnificationXref
id: P48036
db: uniprot

PARTICIPANT STOICHIOMETRY re395 977
type: Stoichiometry
physical entity: MT1-MMP
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__Dnm1-RIGHT__Ras-_re484
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re484 910
participant stoichiometry: PARTICIPANT STOICHIOMETRY re484 911
left: Dnm1
interaction type: UNKNOWN_TRANSITION
right: Ras

PARTICIPANT STOICHIOMETRY re395 976
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

uniprot P19091 201
type: UnificationXref
id: P19091
db: uniprot

ECM s787 sa360 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ECM
stoichiometric coefficient: 1.0

uniprot Q9DC51 211
type: UnificationXref
id: Q9DC51
db: uniprot

PARTICIPANT STOICHIOMETRY re655 639
type: Stoichiometry
physical entity: SMAD2-4_Pbx1_Prep1
stoichiometric coefficient: 1.0

MAP3Ks
type: Protein
entity reference: MAP3Ks
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

FAK
type: Protein
entity reference: FAK
feature: COMPLEX PARTICIPANT BINDING FEATURE s812 sa684 437
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

CTNNB1_SF1
type: Complex
component stoichiometry: CTNNB1 s396 sa410 STOICHIOMETRY ID COMPLEX
component stoichiometry: SF1 s836 sa691 STOICHIOMETRY ID COMPLEX
component: CTNNB1
component: SF1
feature: COMPLEX BINDING FEATURE s835 csa69 446
feature: COMPLEX BINDING FEATURE s835 csa69 444
cellular location: Nucleus

MAP3Ks
type: ProteinReference
xref: P06834
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.MAP3Ks
comment: ENTITY_REFERENCE_NOTES=Map3k1: GeneID: 26401; Map3k2: GeneID: 26405 ; Map3k3: GeneID: 26406 ; Map3k4: GeneID: 26407; Map3k5: GeneID: 26408 ; Map3k6: GeneID: 53608; Map3k7: GeneID: 26409 ; Map3k8: GeneID: 26410 ; Map3k9: GeneID: 338372; Map3k10: GeneID: 269881 ; Map3k11: GeneID: 26403 ; Map3k12: GeneID: 26404; Map3k13: GeneID: 71751 ; Map3k14: GeneID: 53859
member entity reference: Mitogen-activated protein kinase kinase kinase 5
member entity reference: Mitogen-activated protein kinase kinase kinase 9
member entity reference: Mitogen-activated protein kinase kinase kinase 14
member entity reference: Mitogen-activated protein kinase kinase kinase 11
member entity reference: Mitogen-activated protein kinase kinase kinase 2
member entity reference: Mitogen-activated protein kinase kinase kinase 4
member entity reference: Mitogen-activated protein kinase kinase kinase 10
member entity reference: Calmodulin regulator protein PCP4
member entity reference: Mitogen-activated protein kinase kinase kinase 13
member entity reference: Mitogen-activated protein kinase kinase kinase 1
member entity reference: Mitogen-activated protein kinase kinase kinase 12
member entity reference: Mitogen-activated protein kinase kinase kinase 7
member entity reference: Mitogen-activated protein kinase kinase kinase 8
member entity reference: Mitogen-activated protein kinase kinase kinase 3

PARTICIPANT STOICHIOMETRY re626 724
type: Stoichiometry
physical entity: GATA2/4
stoichiometric coefficient: 1.0

P06800
type: UnificationXref
id: P06800
db: PANTHER Pathway Component

uniprot Q61271 241
type: UnificationXref
id: Q61271
db: uniprot

PARTICIPANT STOICHIOMETRY re626 725
type: Stoichiometry
physical entity: 3' LHbeta
stoichiometric coefficient: 1.0

P06801
type: UnificationXref
id: P06801
db: PANTHER Pathway Component

PEA-15
type: Protein
entity reference: PEA-15
feature: PEA 15 s654 sa585 rs1
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Alk4
type: Protein
entity reference: Alk4
feature: COMPLEX PARTICIPANT BINDING FEATURE s709 sa640 275
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__3_QUOTE_SINGLE_FSHbeta-RIGHT__FSHbeta-_re514
control type: INHIBITION
controller: SKIL

Npr2 s436 sa451 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Npr2
stoichiometric coefficient: 1.0

uniprot P40749 13
type: UnificationXref
id: P40749
db: uniprot

Annexin A5
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.Annexin A5
comment: ENTITY_REFERENCE_NOTES=GeneID: 11747

NAB
type: Protein
entity reference: NAB
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

IR
type: ProteinReference
xref: P06802
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.IR
comment: ENTITY_REFERENCE_NOTES= GeneID: 16337
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Insulin receptor

PARTICIPANT STOICHIOMETRY re113 933
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re497 876
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

P06804
type: UnificationXref
id: P06804
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re113 932
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re497 877
type: Stoichiometry
physical entity: COX2
stoichiometric coefficient: 1.0

P06805
type: UnificationXref
id: P06805
db: PANTHER Pathway Component

TCF
type: Protein
entity reference: TCF
feature: COMPLEX PARTICIPANT BINDING FEATURE s74 sa406 367
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

P06802
type: UnificationXref
id: P06802
db: PANTHER Pathway Component

uniprot P97820 17
type: UnificationXref
id: P97820
db: uniprot

P06803
type: UnificationXref
id: P06803
db: PANTHER Pathway Component

P06808
type: UnificationXref
id: P06808
db: PANTHER Pathway Component

ECM_alpha-beta integrin dimer
type: Complex
component stoichiometry: ECM s816 sa672 STOICHIOMETRY ID COMPLEX
component: alpha-beta integrin dimer
component: ECM
feature: COMPLEX PARTICIPANT BINDING FEATURE s814 csa52 435
feature: COMPLEX BINDING FEATURE s814 csa52 392
feature: COMPLEX BINDING FEATURE s814 csa52 390
cellular location: Cytoplasm

P06809
type: UnificationXref
id: P06809
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__IRS-RIGHT__PI3K-_re446
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re446 962
participant stoichiometry: PARTICIPANT STOICHIOMETRY re446 963
left: IRS
interaction type: STATE_TRANSITION
right: PI3K

G06890
type: UnificationXref
id: G06890
db: PANTHER Pathway Component

P06806
type: UnificationXref
id: P06806
db: PANTHER Pathway Component

G06891
type: UnificationXref
id: G06891
db: PANTHER Pathway Component

P06807
type: UnificationXref
id: P06807
db: PANTHER Pathway Component

G06882
type: UnificationXref
id: G06882
db: PANTHER Pathway Component

G06881
type: UnificationXref
id: G06881
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re269 620
type: Stoichiometry
physical entity: Rac1
stoichiometric coefficient: 1.0

G06884
type: UnificationXref
id: G06884
db: PANTHER Pathway Component

EGF
type: Protein
entity reference: EGF
feature: COMPLEX PARTICIPANT BINDING FEATURE s219 sa274 303
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION
type: Control
xref: STATE TRANSITION
controlled: Cell migration
controller: Rac1

G06886
type: UnificationXref
id: G06886
db: PANTHER Pathway Component

P06812
type: UnificationXref
id: P06812
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__Caln-RIGHT__NFAT-_re492
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re492 887
participant stoichiometry: PARTICIPANT STOICHIOMETRY re492 886
left: Caln
interaction type: STATE_TRANSITION
right: NFAT

G06885
type: UnificationXref
id: G06885
db: PANTHER Pathway Component

P06811
type: UnificationXref
id: P06811
db: PANTHER Pathway Component

G06888
type: UnificationXref
id: G06888
db: PANTHER Pathway Component

P06810
type: UnificationXref
id: P06810
db: PANTHER Pathway Component

G06887
type: UnificationXref
id: G06887
db: PANTHER Pathway Component

PKA
type: Protein
entity reference: PKA
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

G06889
type: UnificationXref
id: G06889
db: PANTHER Pathway Component

12-LO
type: ProteinReference
xref: P06815
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 11687
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.12-LO
member entity reference: Arachidonate 15-lipoxygenase

Transcription factor AP-1
type: DnaReference
xref: PTHR11462:SF8
organism: Mus musculus

Vinculin s854 sa524 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Vinculin
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re344
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re344 550
participant stoichiometry: PARTICIPANT STOICHIOMETRY re344 549
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

uniprot Q99JP0 22
type: UnificationXref
id: Q99JP0
db: uniprot

Caln
type: Protein
entity reference: Caln
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

P06813
type: UnificationXref
id: P06813
db: PANTHER Pathway Component

Cdc42
type: Protein
entity reference: Cdc42
feature: COMPLEX PARTICIPANT BINDING FEATURE s265 sa264 355
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

P06814
type: UnificationXref
id: P06814
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re591 708
type: Stoichiometry
physical entity: TORC1
stoichiometric coefficient: 1.0

P06815
type: UnificationXref
id: P06815
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re591 707
type: Stoichiometry
physical entity: Caln
stoichiometric coefficient: 1.0

uniprot P30557 142
type: UnificationXref
id: P30557
db: uniprot

P06817
type: UnificationXref
id: P06817
db: PANTHER Pathway Component

P06818
type: UnificationXref
id: P06818
db: PANTHER Pathway Component

uniprot Q9JIS7 59
type: UnificationXref
id: Q9JIS7
db: uniprot

NOSI
type: DnaRegion
entity reference: NOSI
feature: CRE NOSI s526 sa536 tr1
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

G06880
type: UnificationXref
id: G06880
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__PKA-RIGHT__CREB-_re279
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re279 604
participant stoichiometry: PARTICIPANT STOICHIOMETRY re279 605
left: PKA
interaction type: STATE_TRANSITION
right: CREB

P06819
type: UnificationXref
id: P06819
db: PANTHER Pathway Component

MAP4Ks
type: ProteinReference
xref: P06861
comment: ENTITY_REFERENCE_NOTES=Map4k1: GeneID: 26411 ; Map4k2: GeneID: 26412; Map4k3: GeneID: 225028 ; Map4k4: GeneID: 26921 ; Map4k5: GeneID: 399510
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.MAP4Ks
member entity reference: Mitogen-activated protein kinase kinase kinase kinase 3
member entity reference: Mitogen-activated protein kinase kinase kinase kinase 5
member entity reference: Mitogen-activated protein kinase kinase kinase kinase 4
member entity reference: Mitogen-activated protein kinase kinase kinase kinase 2
member entity reference: Mitogen-activated protein kinase kinase kinase kinase 1

RFRP-1/-3
type: Protein
entity reference: RFRP-1/-3
feature: COMPLEX PARTICIPANT BINDING FEATURE s734 sa653 341
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PR s487 sa236 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PR
stoichiometric coefficient: 1.0

P06821
type: UnificationXref
id: P06821
db: PANTHER Pathway Component

P06820
type: UnificationXref
id: P06820
db: PANTHER Pathway Component

Syt IV
type: ProteinReference
xref: P06746
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Syt IV
comment: ENTITY_REFERENCE_NOTES=GeneID: 20983 SytIV=Synaptotagmin IV
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Synaptotagmin-4

Mitogen-activated protein kinase kinase kinase 14
type: ProteinReference
xref: uniprot Q9WUL6 164
organism: Mus musculus

P06823
type: UnificationXref
id: P06823
db: PANTHER Pathway Component

P06822
type: UnificationXref
id: P06822
db: PANTHER Pathway Component

TRIGGER
type: Control
xref: TRIGGER
controlled: STATE_TRANSITION_LEFT__EIF2AK3-RIGHT__EIF2AK3-_re265
control type: ACTIVATION
controller: Ca2+

PARTICIPANT STOICHIOMETRY re269 619
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

G06879
type: UnificationXref
id: G06879
db: PANTHER Pathway Component

G06878
type: UnificationXref
id: G06878
db: PANTHER Pathway Component

PTHR24416:SF106
type: RelationshipXref
id: PTHR24416:SF106
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__PPARalpha_gamma-RIGHT__Follistatin-_re394
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re394 979
participant stoichiometry: PARTICIPANT STOICHIOMETRY re394 978
left: PPARalpha/gamma
interaction type: STATE_TRANSITION
right: Follistatin

P06828
type: UnificationXref
id: P06828
db: PANTHER Pathway Component

3' LHbeta
type: DnaRegion
entity reference: 3' LHbeta
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

STATE_TRANSITION_LEFT__DAG-RIGHT__PA-_re340
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re340 553
participant stoichiometry: PARTICIPANT STOICHIOMETRY re340 554
left: DAG
interaction type: STATE_TRANSITION
right: PA

P06829
type: UnificationXref
id: P06829
db: PANTHER Pathway Component

P06826
type: UnificationXref
id: P06826
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re42 717
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

P06827
type: UnificationXref
id: P06827
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re42 716
type: Stoichiometry
physical entity: gnas
stoichiometric coefficient: 1.0

P06824
type: UnificationXref
id: P06824
db: PANTHER Pathway Component

cAMP
type: SmallMolecule
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

P06825
type: UnificationXref
id: P06825
db: PANTHER Pathway Component

P06834
type: UnificationXref
id: P06834
db: PANTHER Pathway Component

P06833
type: UnificationXref
id: P06833
db: PANTHER Pathway Component

P06832
type: UnificationXref
id: P06832
db: PANTHER Pathway Component

P06831
type: UnificationXref
id: P06831
db: PANTHER Pathway Component

PTHR23113:SF150
type: RelationshipXref
id: PTHR23113:SF150
db: PANTHER Family
relationship type: By Homology

P06830
type: UnificationXref
id: P06830
db: PANTHER Pathway Component

MISRII
type: Protein
entity reference: MISRII
feature: COMPLEX PARTICIPANT BINDING FEATURE s148 sa210 431
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re563 828
type: Stoichiometry
physical entity: Glut1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re563 827
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

Atf3
type: RnaRegion
entity reference: Atf3
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

Translation attenuation of LHbeta and CGA mRNAs
type: Pathway

PARTICIPANT STOICHIOMETRY re302 616
type: Stoichiometry
physical entity: SMAD2-4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re302 615
type: Stoichiometry
physical entity: AKT
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__Junc-RIGHT__Junc-_re397
type: TemplateReaction
product: Junc
xref: TRANSCRIPTION
participant: Junc
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re617 760
type: Stoichiometry
physical entity: OCT-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re617 761
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

P06839
type: UnificationXref
id: P06839
db: PANTHER Pathway Component

PTHR48013:SF8
type: RelationshipXref
id: PTHR48013:SF8
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: PTHR11584:SF332
xref: uniprot O35099 153
organism: Mus musculus

P06835
type: UnificationXref
id: P06835
db: PANTHER Pathway Component

Voltage-dependent L-type calcium channel subunit alpha-1S
type: ProteinReference
xref: PTHR45628:SF9
xref: uniprot Q02789 57
organism: Mus musculus

Rac1 s660 sa592 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rac1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re431 971
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re503 939
type: Stoichiometry
physical entity: 5' LHbeta
stoichiometric coefficient: 1.0

P06836
type: UnificationXref
id: P06836
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re503 938
type: Stoichiometry
physical entity: Activin A homodimer
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re527 894
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

EGR1 s833 sa688 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EGR1
stoichiometric coefficient: 1.0

P06837
type: UnificationXref
id: P06837
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re527 895
type: Stoichiometry
physical entity: SRC
stoichiometric coefficient: 1.0

P06838
type: UnificationXref
id: P06838
db: PANTHER Pathway Component

uniprot P27090 48
type: UnificationXref
id: P27090
db: uniprot

P06843
type: UnificationXref
id: P06843
db: PANTHER Pathway Component

P06842
type: UnificationXref
id: P06842
db: PANTHER Pathway Component

P06845
type: UnificationXref
id: P06845
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re431 970
type: Stoichiometry
physical entity: IR
stoichiometric coefficient: 1.0

P06844
type: UnificationXref
id: P06844
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re326 575
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

P06841
type: UnificationXref
id: P06841
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re326 576
type: Stoichiometry
physical entity: mPer1
stoichiometric coefficient: 1.0

PTHR48013:SF5
type: RelationshipXref
id: PTHR48013:SF5
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re598 697
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

PEA-15
type: Protein
entity reference: PEA-15
feature: PEA 15 s653 sa584 rs1
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re598 698
type: Stoichiometry
physical entity: Follistatin
stoichiometric coefficient: 1.0

Glut1
type: ProteinReference
xref: P06724
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 20525
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Glut1
member entity reference: Solute carrier family 2, facilitated glucose transporter member 1

PARTICIPANT STOICHIOMETRY re451 958
type: Stoichiometry
physical entity: IRS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re451 959
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

Follistatin
type: DnaRegionReference
member entity reference: Follistatin
xref: G06885
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.Follistatin
comment: ENTITY_REFERENCE_NOTES=GeneID: 14313

GATA2/4
type: ProteinReference
xref: P06859
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.GATA2/4
comment: ENTITY_REFERENCE_NOTES=Gata-2: GeneID: 14461; Gata-4: GeneID: 14463 PMID: 21571865 The data characterize the ability of GATA2 and GATA4 to stimulate LHβ gene promoter activity, both alone and in synergy with SF-1 and LRH-1. The GATA factors act via a DNA-regulatory region which overlaps a previously described Pitx-1 binding site and is positioned between two SF-1/LRH-1 cis-elements.
member entity reference: Endothelial transcription factor GATA-2
member entity reference: Transcription factor GATA-4

uniprot Q61084 161
type: UnificationXref
id: Q61084
db: uniprot

STATE_TRANSITION_LEFT__Caln-RIGHT__TORC1-_re591
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re591 707
participant stoichiometry: PARTICIPANT STOICHIOMETRY re591 708
left: Caln
interaction type: STATE_TRANSITION
right: TORC1

Prx2
type: ProteinReference
xref: P06731
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Prx2
comment: ENTITY_REFERENCE_NOTES=GeneID: 20204
member entity reference: Paired mesoderm homeobox protein 2

Ncoa3
type: ProteinReference
xref: P06719
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Ncoa3
comment: ENTITY_REFERENCE_NOTES= GeneID: 17979
member entity reference: Nuclear receptor coactivator 3

Bone morphogenetic protein 15
type: ProteinReference
xref: PTHR11848:SF22
xref: uniprot Q9Z0L4 215
organism: Mus musculus

uniprot Q6R0H7 208
type: UnificationXref
id: Q6R0H7
db: uniprot

BMP2/4/15_BMPR-IA/IB/II
type: Complex
component stoichiometry: BMPR IA IB II s191 sa213 STOICHIOMETRY ID COMPLEX
component stoichiometry: BMP2 4 15 s297 sa255 STOICHIOMETRY ID COMPLEX
component: BMP2/4/15
component: BMPR-IA/IB/II
feature: COMPLEX BINDING FEATURE s766 csa37 492
feature: COMPLEX BINDING FEATURE s766 csa37 490
cellular location: Cytoplasm

STATE_TRANSITION_LEFT__EIF2AK3-RIGHT__EIF2A-_re266
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re266 623
participant stoichiometry: PARTICIPANT STOICHIOMETRY re266 624
left: EIF2AK3
interaction type: STATE_TRANSITION
right: EIF2A

Lepr
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s638 sa567 395
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Alk4
type: Protein
entity reference: Alk4
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

MT1-MMP
type: ProteinReference
xref: P06716
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 17387
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.MT1-MMP
member entity reference: Matrix metalloproteinase-14

STATE_TRANSITION_LEFT__FOS_Jund-RIGHT__PACAP-_re613
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re613 769
participant stoichiometry: PARTICIPANT STOICHIOMETRY re613 768
left: FOS_Jund
interaction type: STATE_TRANSITION
right: PACAP

Mitogen-activated protein kinase 11
type: ProteinReference
xref: uniprot Q9WUI1 86
xref: PTHR24055:SF109
organism: Mus musculus

Rac1
type: Protein
entity reference: Rac1
feature: ACTIVE 226
feature: COMPLEX PARTICIPANT BINDING FEATURE s616 sa549 505
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

IGF-1
type: ProteinReference
xref: P06854
comment: ENTITY_REFERENCE_NOTES= GeneID: 16000
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.IGF-1
member entity reference: Insulin-like growth factor I

ERK1/2
type: Protein
entity reference: ERK1/2
feature: COMPLEX PARTICIPANT BINDING FEATURE s875 sa704 471
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

IGF 1R s468 sa481 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IGF-1R
stoichiometric coefficient: 1.0

uniprot Q04999 128
type: UnificationXref
id: Q04999
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot P29387 191
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re638 684
type: Stoichiometry
physical entity: EGR1_p300_SF1
stoichiometric coefficient: 1.0

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P60766 169
xref: PTHR24072:SF136
organism: Mus musculus

uniprot P70236 32
type: UnificationXref
id: P70236
db: uniprot

PARTICIPANT STOICHIOMETRY re5 527
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Caln-RIGHT__TORC1-_re588
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re588 740
participant stoichiometry: PARTICIPANT STOICHIOMETRY re588 741
left: Caln
interaction type: STATE_TRANSITION
right: TORC1

PARTICIPANT STOICHIOMETRY re5 526
type: Stoichiometry
physical entity: MEK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re638 681
type: Stoichiometry
physical entity: EGR1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re638 682
type: Stoichiometry
physical entity: p300
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re638 683
type: Stoichiometry
physical entity: SF1
stoichiometric coefficient: 1.0

ActivinA_ActRII/IIB
type: Complex
component stoichiometry: Activin A homodimer s719 csa27 STOICHIOMETRY ID COMPLEX
component stoichiometry: ActRII IIB s726 sa643 STOICHIOMETRY ID COMPLEX
component: ActRII/IIB
component: Activin A homodimer
feature: COMPLEX BINDING FEATURE s769 csa28 422
feature: COMPLEX BINDING FEATURE s769 csa28 424
cellular location: Cytoplasm

AC
type: ProteinReference
xref: P06699
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Adcy1: GeneID: 432530
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.AC
member entity reference: Adenylate cyclase type 1

STATE_TRANSITION_LEFT__Alk4_ActivinA_ActRII_IIB-RIGHT__Pbx1-_re335
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re335 562
participant stoichiometry: PARTICIPANT STOICHIOMETRY re335 561
left: Alk4_ActivinA_ActRII/IIB
interaction type: STATE_TRANSITION
right: Pbx1

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 195
xref: PTHR19850:SF31
organism: Mus musculus

uniprot Q9ESQ8 224
type: UnificationXref
id: Q9ESQ8
db: uniprot

PAC1 R s283 sa334 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PAC1-R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re136 880
type: Stoichiometry
physical entity: AdipoR1/R2
stoichiometric coefficient: 1.0

PKCe/theta
type: Protein
entity reference: PKCe/theta
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Paxillin
type: ProteinReference
xref: P06784
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Paxillin
comment: ENTITY_REFERENCE_NOTES= GeneID: 19303
member entity reference: Paxillin

Isl-1
type: RnaRegionReference
comment: ENTITY_REFERENCE_NOTES=Gene ID: 16392
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.Isl-1

nPKCs
type: ProteinReference
xref: P06852
comment: ENTITY_REFERENCE_NOTES=nPKCs=novel PKCs protein kinase C, delta: GeneID: 18753 ; protein kinase C, epsilon: GeneID: 18754
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.nPKCs
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C delta type

Inhba
type: Protein
entity reference: Inhba
feature: COMPLEX PARTICIPANT BINDING FEATURE s730 sa649 271
comment: SPECIES_TYPE=PROTEIN

uniprot P09055 136
type: UnificationXref
id: P09055
db: uniprot

Caveolin 1 s870 sa699 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Caveolin-1
stoichiometric coefficient: 1.0

JUN s152 sa212 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re136 881
type: Stoichiometry
physical entity: AMPK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re426 988
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re426 989
type: Stoichiometry
physical entity: DUSP1
stoichiometric coefficient: 1.0

Prep1
type: ProteinReference
xref: P06829
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Prep1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= GeneID: 18771 PMID: 14764653 It shows that prep1 binds to FSHb promoter region and mutation at prep1 binding site totally abrogates the induction of FSHb promoter activity by activin. It shows that prep1 forms complex with smads and pbx1.
member entity reference: Homeobox protein PKNOX1

JUN
type: Protein
entity reference: JUN
feature: COMPLEX PARTICIPANT BINDING FEATURE s479 sa505 329
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Grb2 s495 sa513 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

PTHR24361:SF656
type: RelationshipXref
id: PTHR24361:SF656
db: PANTHER Family
relationship type: By Homology

UNKNOWN_TRANSITION_LEFT__JNK1_2-RIGHT__Follistatin-_re324
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re324 579
participant stoichiometry: PARTICIPANT STOICHIOMETRY re324 580
left: JNK1/2
interaction type: UNKNOWN_TRANSITION
right: Follistatin

Nitric oxide synthase, brain
type: ProteinReference
xref: uniprot Q9Z0J4 100
organism: Mus musculus

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: uniprot P53349 154
xref: PTHR24361:SF414
organism: Mus musculus

ActRII
type: ProteinReference
xref: P06747
comment: ENTITY_REFERENCE_NOTES= GeneID: 11480
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.ActRII
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Activin receptor type-2A

PARTICIPANT STOICHIOMETRY re287 588
type: Stoichiometry
physical entity: EGR1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re287 587
type: Stoichiometry
physical entity: ER
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re482 917
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

Evidence 141
type: Evidence
evidence code: RCA
comment: SPACC Q99N57

STATE_TRANSITION_LEFT__CREB-RIGHT__PACAP-_re612
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re612 771
participant stoichiometry: PARTICIPANT STOICHIOMETRY re612 770
left: CREB
interaction type: STATE_TRANSITION
right: PACAP

EGR1
type: DnaRegion
entity reference: EGR1
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

STATE_TRANSITION_LEFT__SRC-RIGHT__Rac1-_re269
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re269 620
participant stoichiometry: PARTICIPANT STOICHIOMETRY re269 619
left: SRC
interaction type: STATE_TRANSITION
right: Rac1

uniprot Q02248 83
type: UnificationXref
id: Q02248
db: uniprot

PARTICIPANT STOICHIOMETRY re339 556
type: Stoichiometry
physical entity: CGA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re339 555
type: Stoichiometry
physical entity: LTs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re482 916
type: Stoichiometry
physical entity: L-type Ca2+
stoichiometric coefficient: 1.0

PTHR19304:SF9
type: RelationshipXref
id: PTHR19304:SF9
db: PANTHER Family
relationship type: By Homology

TORC1
type: ProteinReference
xref: P06788
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.TORC1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 382056
member entity reference: CREB-regulated transcription coactivator 1

PTHR13703:SF45
type: RelationshipXref
id: PTHR13703:SF45
db: PANTHER Family
relationship type: By Homology

TRANSCRIPTION_LEFT__Rap1b-RIGHT__Rap1b-_re568
type: TemplateReaction
product: Rap1b
xref: TRANSCRIPTION
participant: Rap1b
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot P32240 143
type: UnificationXref
id: P32240
db: uniprot

MEK1/2
type: Protein
entity reference: MEK1/2
feature: COMPLEX PARTICIPANT BINDING FEATURE s874 sa703 469
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR13703:SF41
type: RelationshipXref
id: PTHR13703:SF41
db: PANTHER Family
relationship type: By Homology

PTHR13703:SF42
type: RelationshipXref
id: PTHR13703:SF42
db: PANTHER Family
relationship type: By Homology

SKIL
type: ProteinReference
xref: P06858
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 6498
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.SKIL
member entity reference: Ski-like protein

PTHR10201:SF24
type: RelationshipXref
id: PTHR10201:SF24
db: PANTHER Family
relationship type: By Homology

uniprot Q5EG47 217
type: UnificationXref
id: Q5EG47
db: uniprot

PARTICIPANT STOICHIOMETRY re489 898
type: Stoichiometry
physical entity: AA
stoichiometric coefficient: 1.0

PAC1-R
type: ProteinReference
xref: P06712
comment: ENTITY_REFERENCE_NOTES= GeneID: 11517
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.PAC1-R
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Pituitary adenylate cyclase-activating polypeptide type I receptor

PARTICIPANT STOICHIOMETRY re530 874
type: Stoichiometry
physical entity: Unknown GPCR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re530 875
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

uniprot P45481 244
type: UnificationXref
id: P45481
db: uniprot

PARTICIPANT STOICHIOMETRY re489 899
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re557 845
type: Stoichiometry
physical entity: MEK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re557 844
type: Stoichiometry
physical entity: Linoleate
stoichiometric coefficient: 1.0

PTHR13703:SF36
type: RelationshipXref
id: PTHR13703:SF36
db: PANTHER Family
relationship type: By Homology

G06903
type: UnificationXref
id: G06903
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__PKCs-RIGHT__CREB-_re491
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re491 889
participant stoichiometry: PARTICIPANT STOICHIOMETRY re491 888
left: PKCs
interaction type: STATE_TRANSITION
right: CREB

G06902
type: UnificationXref
id: G06902
db: PANTHER Pathway Component

G06901
type: UnificationXref
id: G06901
db: PANTHER Pathway Component

G06900
type: UnificationXref
id: G06900
db: PANTHER Pathway Component

TRIGGER
type: RelationshipTypeVocabulary

G06905
type: UnificationXref
id: G06905
db: PANTHER Pathway Component

PTHR13703:SF53
type: RelationshipXref
id: PTHR13703:SF53
db: PANTHER Family
relationship type: By Homology

Caveolin-1
type: Protein
entity reference: Caveolin-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s870 sa699 461
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

G06904
type: UnificationXref
id: G06904
db: PANTHER Pathway Component

NF Y s310 sa202 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NF-Y
stoichiometric coefficient: 1.0

Transcription factor GATA-4
type: ProteinReference
xref: uniprot Q08369 119
organism: Mus musculus

PITX
type: Protein
entity reference: PITX
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot O09110 31
type: UnificationXref
id: O09110
db: uniprot

uniprot P13562 53
type: UnificationXref
id: P13562
db: uniprot

UNKNOWN_TRANSITION_LEFT__GnRHR-RIGHT__PAC1R-_re520
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re520 904
participant stoichiometry: PARTICIPANT STOICHIOMETRY re520 905
left: GnRHR
interaction type: UNKNOWN_TRANSITION
right: PAC1R

uniprot P36895 121
type: UnificationXref
id: P36895
db: uniprot

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s495 sa513 409
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__c_Raf-RIGHT__MEK1_2-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 529
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 528
left: c-Raf
interaction type: STATE_TRANSITION
right: MEK1/2

Nuclear transcription factor Y subunit beta
type: ProteinReference
xref: uniprot P63139 10
organism: Mus musculus

STATE_TRANSITION_LEFT__MKK3_6-RIGHT__p38-_re271
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re271 610
participant stoichiometry: PARTICIPANT STOICHIOMETRY re271 611
left: MKK3/6
interaction type: STATE_TRANSITION
right: p38

uniprot O09000 129
type: UnificationXref
id: O09000
db: uniprot

uniprot Q63844 30
type: UnificationXref
id: Q63844
db: uniprot

PARTICIPANT STOICHIOMETRY re170 804
type: Stoichiometry
physical entity: 3' LHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re170 803
type: Stoichiometry
physical entity: 5-HT3AR
stoichiometric coefficient: 1.0

5-HT3AR
type: Protein
entity reference: 5-HT3AR
feature: COMPLEX PARTICIPANT BINDING FEATURE s124 sa178 427
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR13703:SF23
type: RelationshipXref
id: PTHR13703:SF23
db: PANTHER Family
relationship type: By Homology

Glut1
type: DnaRegionReference
member entity reference: Solute carrier family 2, facilitated glucose transporter member 1
xref: G06890
comment: ENTITY_REFERENCE_NOTES=GeneID: 20525
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.Glut1

TRANSCRIPTION_LEFT__Annexin_A5-RIGHT__Annexin_A5-_re300
type: TemplateReaction
product: Annexin A5
xref: TRANSCRIPTION
participant: Annexin A5
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

DUSP1
type: Protein
entity reference: DUSP1
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re518 920
type: Stoichiometry
physical entity: PGs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re518 921
type: Stoichiometry
physical entity: PGs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re578 774
type: Stoichiometry
physical entity: Caln
stoichiometric coefficient: 1.0

TAK1
type: Protein
entity reference: TAK1
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Rac1_GDP
type: Complex
component stoichiometry: GDP s670 sa602 STOICHIOMETRY ID COMPLEX
component stoichiometry: Rac1 s660 sa592 STOICHIOMETRY ID COMPLEX
component: GDP
component: Rac1
feature: COMPLEX BINDING FEATURE s843 csa72 282
feature: COMPLEX BINDING FEATURE s843 csa72 284
cellular location: Cytoplasm

Pituitary adenylate cyclase-activating polypeptide type I receptor
type: DnaReference
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re578 775
type: Stoichiometry
physical entity: NFAT
stoichiometric coefficient: 1.0

PTHR11848:SF22
type: RelationshipXref
id: PTHR11848:SF22
db: PANTHER Family
relationship type: By Homology

EGF s219 sa274 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EGF
stoichiometric coefficient: 1.0

Prolactin s195 sa254 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Prolactin
stoichiometric coefficient: 1.0

Activin A homodimer
type: Complex
component stoichiometry: Inhba s720 sa644 STOICHIOMETRY ID COMPLEX
component: Inhba
feature: COMPLEX PARTICIPANT BINDING FEATURE s719 csa27 423
feature: COMPLEX BINDING FEATURE s719 csa27 420
cellular location: Cytoplasm

UNKNOWN_TRANSITION_LEFT__PKCe_theta-RIGHT__3_QUOTE_SINGLE_LHbeta-_re561
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re561 835
participant stoichiometry: PARTICIPANT STOICHIOMETRY re561 834
left: PKCe/theta
interaction type: UNKNOWN_TRANSITION
right: 3' LHbeta

ECM alpha beta integrin dimer s814 csa52 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ECM_alpha-beta integrin dimer
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__GnRHR-RIGHT__Dnm1-_re483
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re483 914
participant stoichiometry: PARTICIPANT STOICHIOMETRY re483 915
left: GnRHR
interaction type: UNKNOWN_TRANSITION
right: Dnm1

uniprot P06879 38
type: UnificationXref
id: P06879
db: uniprot

STATE_TRANSITION_LEFT__p38-RIGHT__EGR1-_re276
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re276 607
participant stoichiometry: PARTICIPANT STOICHIOMETRY re276 606
left: p38
interaction type: STATE_TRANSITION
right: EGR1

LHX2
type: Protein
entity reference: LHX2
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Bone morphogenetic protein 6
type: ProteinReference
xref: uniprot P20722 60
xref: PTHR11848:SF137
organism: Mus musculus

Small nuclear ribonucleoprotein-associated protein N
type: ProteinReference
xref: uniprot P63163 239
organism: Mus musculus

gnaq 11 s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: gnaq/11
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re650 648
type: Stoichiometry
physical entity: 5' FSHbeta
stoichiometric coefficient: 1.0

CTNNB1
type: ProteinReference
xref: P06838
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.CTNNB1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 12387
member entity reference: Catenin beta-1

PARTICIPANT STOICHIOMETRY re650 647
type: Stoichiometry
physical entity: PR
stoichiometric coefficient: 1.0

SMAD2-4
type: Protein
entity reference: SMAD2-4
feature: COMPLEX PARTICIPANT BINDING FEATURE s684 sa233 495
feature: SMAD2 4 s684 sa233 rs1
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Vinculin s869 sa698 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Vinculin
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Cdc42-RIGHT__MAP4Ks-_re317
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re317 601
participant stoichiometry: PARTICIPANT STOICHIOMETRY re317 600
left: Cdc42
interaction type: STATE_TRANSITION
right: MAP4Ks

STATE_TRANSITION_LEFT__Ca_CaMK_II-RIGHT__SRF-_re543
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re543 865
participant stoichiometry: PARTICIPANT STOICHIOMETRY re543 864
left: Ca/CaMK II
interaction type: STATE_TRANSITION
right: SRF

FOS
type: Protein
entity reference: FOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s824 sa508 385
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P01326 49
type: UnificationXref
id: P01326
db: uniprot

STATE_TRANSITION_LEFT__SRC-RIGHT__EGFR-_re473
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re473 930
participant stoichiometry: PARTICIPANT STOICHIOMETRY re473 931
left: SRC
interaction type: STATE_TRANSITION
right: EGFR

Mitogen-activated protein kinase kinase kinase kinase 3
type: ProteinReference
xref: uniprot Q99JP0 22
organism: Mus musculus

Early growth response protein 1
type: ProteinReference
xref: uniprot P08046 189
organism: Mus musculus

uniprot Q62053 147
type: UnificationXref
id: Q62053
db: uniprot

Dopamine s194 sa253 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

uniprot P26450 124
type: UnificationXref
id: P26450
db: uniprot

go GO:0005737 5
type: UnificationXref
id: GO:0005737
db: go

Tubulin
type: Protein
entity reference: Tubulin
feature: COMPLEX PARTICIPANT BINDING FEATURE s852 sa522 307
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P16951 46
type: UnificationXref
id: P16951
db: uniprot

PARTICIPANT STOICHIOMETRY re263 628
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re263 627
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re539 869
type: Stoichiometry
physical entity: Rac1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re539 868
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot P43252 146
type: UnificationXref
id: P43252
db: uniprot

PTHR24057:SF8
type: RelationshipXref
id: PTHR24057:SF8
db: PANTHER Family
relationship type: By Homology

MT1-MMP
type: Protein
entity reference: MT1-MMP
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

UNKNOWN_INHIBITION
type: Control
xref: UNKNOWN INHIBITION
controlled: STATE_TRANSITION_LEFT__SMAD1_5_8-RIGHT__SMAD1_5_8-_re552
control type: INHIBITION
controller: GnRH

SRC
type: Protein
entity reference: SRC
feature: COMPLEX PARTICIPANT BINDING FEATURE s877 sa706 475
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR48013:SF12
type: RelationshipXref
id: PTHR48013:SF12
db: PANTHER Family
relationship type: By Homology

MAP4Ks
type: Protein
entity reference: MAP4Ks
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR48013:SF15
type: RelationshipXref
id: PTHR48013:SF15
db: PANTHER Family
relationship type: By Homology

PTHR48013:SF17
type: RelationshipXref
id: PTHR48013:SF17
db: PANTHER Family
relationship type: By Homology

PAC1R
type: DnaRegionReference
member entity reference: Pituitary adenylate cyclase-activating polypeptide type I receptor
xref: G06898
comment: ENTITY_REFERENCE_NOTES=Gene ID: 11517
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.PAC1R

PARTICIPANT STOICHIOMETRY re547 863
type: Stoichiometry
physical entity: ELK1
stoichiometric coefficient: 1.0

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31750 69
organism: Mus musculus

Dnm1
type: Protein
entity reference: Dnm1
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Fosb
type: DnaRegion
entity reference: Fosb
feature: ERE Fosb s440 sa455 tr1
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

uniprot P28867 26
type: UnificationXref
id: P28867
db: uniprot

EGR1_p300_SF1
type: Complex
component stoichiometry: SF1 s832 sa689 STOICHIOMETRY ID COMPLEX
component stoichiometry: EGR1 s833 sa688 STOICHIOMETRY ID COMPLEX
component stoichiometry: p300 s164 sa220 STOICHIOMETRY ID COMPLEX
component: SF1
component: EGR1
component: p300
feature: COMPLEX BINDING FEATURE s831 csa68 438
feature: COMPLEX BINDING FEATURE s831 csa68 442
feature: COMPLEX BINDING FEATURE s831 csa68 440
cellular location: Nucleus

PARTICIPANT STOICHIOMETRY re547 862
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

3' FSHbeta
type: DnaRegion
entity reference: 3' FSHbeta
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

uniprot P60766 169
type: UnificationXref
id: P60766
db: uniprot

EIF2AK3
type: Protein
entity reference: EIF2AK3

PTHR48013:SF21
type: RelationshipXref
id: PTHR48013:SF21
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol-glycan-specific phospholipase D
type: ProteinReference
xref: uniprot O70362 176
organism: Mus musculus

STATE_TRANSITION_LEFT__Activin_A_homodimer-RIGHT__ActRII_IIB-_re571
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re571 793
participant stoichiometry: PARTICIPANT STOICHIOMETRY re571 794
left: Activin A homodimer
interaction type: STATE_TRANSITION
right: ActRII/IIB

PARTICIPANT STOICHIOMETRY re496 878
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

Ca/CaMK II
type: Protein
entity reference: Ca/CaMK II
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Unknown GPCR
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s651 sa582 371
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re263
control type: ACTIVATION
controller: IP3

PARTICIPANT STOICHIOMETRY re496 879
type: Stoichiometry
physical entity: p65
stoichiometric coefficient: 1.0

ER
type: Protein
entity reference: ER
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re634 688
type: Stoichiometry
physical entity: 3' LHbeta
stoichiometric coefficient: 1.0

CREB-regulated transcription coactivator 1
type: ProteinReference
xref: uniprot Q68ED7 187
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re465 944
type: Stoichiometry
physical entity: AR
stoichiometric coefficient: 1.0

Adiponectin
type: Protein
entity reference: Adiponectin
feature: COMPLEX PARTICIPANT BINDING FEATURE s202 sa260 519
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR24416:SF535
type: RelationshipXref
id: PTHR24416:SF535
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re465 945
type: Stoichiometry
physical entity: SF1
stoichiometric coefficient: 1.0

Epidermal growth factor receptor
type: ProteinReference
xref: PTHR24416:SF91
xref: uniprot Q01279 165
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re634 687
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

SRC_DGK-zeta
type: Complex
component stoichiometry: DGK zeta s336 sa346 STOICHIOMETRY ID COMPLEX
component stoichiometry: SRC s499 sa348 STOICHIOMETRY ID COMPLEX
component: DGK-zeta
component: SRC
feature: COMPLEX BINDING FEATURE s750 csa19 364
feature: COMPLEX BINDING FEATURE s750 csa19 362
cellular location: Cytoplasm

uniprot P49817 81
type: UnificationXref
id: P49817
db: uniprot

PITX
type: ProteinReference
xref: P06722
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PITX
comment: ENTITY_REFERENCE_NOTES=Pitx1: GeneID: 18740 ; Pitx2: GeneID: 18741 PMID: 15961509 PMID: 18339718 This study shows that PITXs bind to FSHb promoter and mutation at binding site reduces the basal and induced activity of FSHb, but not fold induction. PITXs interacts with smad3 when activin is provided. PMID: 12554780 This study shows that pitx binds to FSHb promoter, and the overexpression of pitx increases the promoter activity of FSHb. PMID: 11328855 Mutation on pitx1 site reduces both basal and induced LHb activity. PMID: 16087728 Pitx1 stimulates the rat LHbeta gene promoter via two Pitx1 DNA-regulatory regions.
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Pituitary homeobox 1
member entity reference: Pituitary homeobox 2

PPARgamma
type: ProteinReference
xref: P06721
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PPARgamma
comment: ENTITY_REFERENCE_NOTES=GeneID: 19016
member entity reference: Peroxisome proliferator-activated receptor gamma

Csda
type: ProteinReference
xref: P06797
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Csda
comment: ENTITY_REFERENCE_NOTES=GeneID: 56449
member entity reference: Y-box-binding protein 3

p300
type: Protein
entity reference: p300
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re318 599
type: Stoichiometry
physical entity: MAP3Ks
stoichiometric coefficient: 1.0

Annexin A5
type: DnaRegion
entity reference: Annexin A5
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

Pbx1
type: Protein
entity reference: Pbx1
feature: COMPLEX PARTICIPANT BINDING FEATURE s140 sa200 451
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re318 598
type: Stoichiometry
physical entity: MAP4Ks
stoichiometric coefficient: 1.0

Insulin receptor
type: ProteinReference
xref: PTHR24416:SF535
xref: uniprot P15208 35
organism: Mus musculus

Nuclear factor of activated T-cells, cytoplasmic 4
type: ProteinReference
xref: uniprot Q8K120 107
xref: PTHR12533:SF11
organism: Mus musculus

LIM/homeobox protein Lhx2
type: ProteinReference
xref: uniprot Q9Z0S2 54
organism: Mus musculus

LHbeta
type: RnaRegion
entity reference: LHbeta
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTP-RIGHT__Rac1-_re539
controller: RICS

PARTICIPANT STOICHIOMETRY re484 910
type: Stoichiometry
physical entity: Dnm1
stoichiometric coefficient: 1.0

P06699
type: UnificationXref
id: P06699
db: PANTHER Pathway Component

KSR 1 s857 sa527 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: KSR-1
stoichiometric coefficient: 1.0

TRANSLATION_LEFT__Annexin_A5-RIGHT__Annexin_A5-_re356
type: TemplateReaction
product: Annexin A5
xref: TRANSLATION
participant: Annexin A5
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

RICS
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.RICS
comment: ENTITY_REFERENCE_NOTES=Gene ID: 330914

PARTICIPANT STOICHIOMETRY re484 911
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re173 801
type: Stoichiometry
physical entity: SNURF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re173 802
type: Stoichiometry
physical entity: SF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re644 666
type: Stoichiometry
physical entity: CGA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re644 665
type: Stoichiometry
physical entity: SF1
stoichiometric coefficient: 1.0

Cdc42 s265 sa264 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cdc42
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__SRC-RIGHT__Cdc42-_re596
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re596 702
participant stoichiometry: PARTICIPANT STOICHIOMETRY re596 701
left: SRC
interaction type: STATE_TRANSITION
right: Cdc42

UNKNOWN_TRANSITION_LEFT__GnRHR-RIGHT__L_type_Ca2_PLUS_-_re347
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re347 544
participant stoichiometry: PARTICIPANT STOICHIOMETRY re347 543
left: GnRHR
interaction type: UNKNOWN_TRANSITION
right: L-type Ca2+

…
type: Stoichiometry
physical entity: alpha-beta integrin dimer
stoichiometric coefficient: 2.0

Pcaf s442 sa458 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pcaf
stoichiometric coefficient: 1.0

Glut1
type: Protein
entity reference: Glut1
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

COX2
type: DnaRegionReference
member entity reference: Cytochrome c oxidase subunit 2
xref: G06899
comment: ENTITY_REFERENCE_NOTES=GeneID: 5912281
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.COX2

CATALYSIS
type: Catalysis
controller: Syt IV

Peroxisome proliferator-activated receptor alpha
type: ProteinReference
xref: uniprot P23204 95
organism: Mus musculus

3' FSHbeta
type: DnaRegionReference
member entity reference: Follitropin subunit beta
xref: G06900
comment: ENTITY_REFERENCE_NOTES=GeneID: 14308
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.3' FSHbeta

PARTICIPANT STOICHIOMETRY re597 700
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

Insulin receptor substrate 4
type: ProteinReference
xref: uniprot Q9Z0Y7 184
xref: PTHR10614:SF2
organism: Mus musculus

Nur77
type: DnaRegion
entity reference: Nur77
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

SNURF
type: Protein
entity reference: SNURF
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

SMAD2-4
type: Protein
entity reference: SMAD2-4
feature: SMAD2 4 s682 sa614 rs1
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q8BQS5 51
type: UnificationXref
id: Q8BQS5
db: uniprot

PARTICIPANT STOICHIOMETRY re553 849
type: Stoichiometry
physical entity: 5' FSHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re553 848
type: Stoichiometry
physical entity: SMAD1/5/8
stoichiometric coefficient: 1.0

PITX s385 sa404 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PITX
stoichiometric coefficient: 1.0

Androgen receptor
type: ProteinReference
xref: uniprot P19091 201
organism: Mus musculus

Ski-like protein
type: ProteinReference
xref: uniprot P12757 82
xref: PTHR10005:SF3
organism: Homo sapiens

TORC1 s744 sa668 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TORC1
stoichiometric coefficient: 1.0

AR
type: ProteinReference
xref: P06774
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.AR
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 11835 PMID: 16675544 This study uses overexpression of the AR in order to show regulation of the FSHb promoter. This does not necessarily provide evidence of endogenous responsiveness to androgen. PMID: 18079204 This study shows that AR interacts with smad2/3/4 in vitro, and androgen and activin act synergistically to induce FSHb promoter activity when AR is overexpressed. PMID: 11682622 In the study, DHT treatment increases the mRNA expression level of GnRH receptor. PMID: 11682622 This study shows that SP1 binds to the proximal and distal promoter regions of LHb promoter. DHT treatment reduces LHb promoter activity by 75% and is dependent on functional AR. AR directly interacts with SP1 where the interaction reduces SP1 binding to LHb promoter.
member entity reference: Androgen receptor

PTHR11584:SF332
type: RelationshipXref
id: PTHR11584:SF332
db: PANTHER Family
relationship type: By Homology

ECM
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s816 sa672 393
comment: SPECIES_TYPE=PROTEIN

UNKNOWN_TRANSITION_LEFT__PLA2-RIGHT__COX2-_re494
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re494 884
participant stoichiometry: PARTICIPANT STOICHIOMETRY re494 885
left: PLA2
interaction type: UNKNOWN_TRANSITION
right: COX2

Son of sevenless homolog 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot Q02384 36
organism: Mus musculus

uniprot P68369 131
type: UnificationXref
id: P68369
db: uniprot

TGIF1
type: ProteinReference
xref: P06725
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 7050
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.TGIF1
member entity reference: Homeobox protein TGIF1

Secretogranin-2
type: DnaReference
organism: Mus musculus

Inha
type: Protein
entity reference: Inha
feature: COMPLEX PARTICIPANT BINDING FEATURE s706 sa638 359
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Rap1b
type: DnaRegionReference
member entity reference: Ras-related protein Rap-1b
xref: G06881
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.Rap1b
comment: ENTITY_REFERENCE_NOTES=GeneID: 215449

uniprot Q06348 33
type: UnificationXref
id: Q06348
db: uniprot

TRANSCRIPTION_LEFT__EGR1-RIGHT__EGR1-_re288
type: TemplateReaction
product: EGR1
xref: TRANSCRIPTION
participant: EGR1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Caln
type: ProteinReference
xref: P06728
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Caln
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 19055
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Nuclear factor of activated T-cells, cytoplasmic 1
type: ProteinReference
xref: uniprot O88942 104
organism: Mus musculus

CGA
type: DnaRegionReference
member entity reference: Glycoprotein hormones alpha chain
xref: G06886
comment: ENTITY_REFERENCE_NOTES=GeneID: 12640
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.CGA

Grb2
type: ProteinReference
xref: P06856
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Grb2
comment: ENTITY_REFERENCE_NOTES= GeneID: 14784
member entity reference: Growth factor receptor-bound protein 2

TRANSLATION_LEFT__Rap1b-RIGHT__Rap1b-_re569
type: TemplateReaction
product: Rap1b
xref: TRANSLATION
participant: Rap1b
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

PARTICIPANT STOICHIOMETRY re157 856
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

SRC
type: Protein
entity reference: SRC
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Histone acetyltransferase p300
type: ProteinReference
xref: PTHR13808:SF29
xref: uniprot B2RWS6 238
organism: Mus musculus

SMAD2 4 s684 sa233 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.39269908169872414

PARTICIPANT STOICHIOMETRY re157 857
type: Stoichiometry
physical entity: SF1
stoichiometric coefficient: 1.0

c-fos
type: DnaRegion
entity reference: c-fos
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

uniprot Q64GA5 233
type: UnificationXref
id: Q64GA5
db: uniprot

uniprot P27040 180
type: UnificationXref
id: P27040
db: uniprot

uniprot P39053 103
type: UnificationXref
id: P39053
db: uniprot

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 231
xref: PTHR10728:SF13
xref: uniprot P47713 230
organism: Mus musculus

SN s652 sa583 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SN
stoichiometric coefficient: 1.0

p65
type: ProteinReference
xref: P06702
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= GeneID: 5970
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.p65
member entity reference: Transcription factor p65

ATF2
type: Protein
entity reference: ATF2
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Leptin_Lepr_JAK1
type: Complex
component stoichiometry: JAK1 s640 sa569 STOICHIOMETRY ID COMPLEX
component stoichiometry: Leptin s639 sa568 STOICHIOMETRY ID COMPLEX
component stoichiometry: Lepr s638 sa567 STOICHIOMETRY ID COMPLEX
component: Leptin
component: JAK1
component: Lepr
feature: COMPLEX BINDING FEATURE s776 csa45 394
feature: COMPLEX BINDING FEATURE s776 csa45 396
feature: COMPLEX BINDING FEATURE s776 csa45 398
cellular location: Cytoplasm

NOSI
type: DnaRegionReference
member entity reference: Nitric oxide synthase, brain
xref: G06888
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.NOSI
comment: ENTITY_REFERENCE_NOTES=GeneID: 18125 NOSI=neuronal Nitric Oxide Synthase type I

Annexin A5
type: ProteinReference
xref: uniprot P48036 75
organism: Mus musculus

uniprot Q91VH1 52
type: UnificationXref
id: Q91VH1
db: uniprot

TRANSLATION_LEFT__Follistatin-RIGHT__Follistatin-_re375
type: TemplateReaction
product: Follistatin
xref: TRANSLATION
participant: Follistatin
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

PARTICIPANT STOICHIOMETRY re254 651
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re254 652
type: Stoichiometry
physical entity: Ca/CaMK II
stoichiometric coefficient: 1.0

Caveolin-1
type: ProteinReference
xref: P06763
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Caveolin-1
comment: ENTITY_REFERENCE_NOTES= GeneID: 12389
member entity reference: Caveolin-1

PARTICIPANT STOICHIOMETRY re570 795
type: Stoichiometry
physical entity: GnRH_GnRHR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re570 796
type: Stoichiometry
physical entity: Rap1b
stoichiometric coefficient: 1.0

FAK s856 sa526 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__SMAD2_4-RIGHT__SMAD2_4-_re551
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re551 853
participant stoichiometry: PARTICIPANT STOICHIOMETRY re551 852
left: SMAD2-4
interaction type: STATE_TRANSITION
right: SMAD2-4

Lepr s638 sa567 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Lepr
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION
type: Control
xref: UNKNOWN TRANSITION
controlled: Cell mitosis
controller: SMAD2-4

STATE_TRANSITION_LEFT__SMAD_PITX_OTX-RIGHT__3_QUOTE_SINGLE_LHbeta-_re636
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re636 685
participant stoichiometry: PARTICIPANT STOICHIOMETRY re636 686
left: SMAD_PITX_OTX
interaction type: STATE_TRANSITION
right: 3' LHbeta

Protein kinase C delta type
type: ProteinReference
xref: uniprot P28867 26
xref: PTHR24356:SF365
organism: Mus musculus

SRF
type: ProteinReference
xref: P06811
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.SRF
comment: ENTITY_REFERENCE_NOTES= GeneID: 20807
member entity reference: Serum response factor

PTHR24070:SF393
type: RelationshipXref
id: PTHR24070:SF393
db: PANTHER Family
relationship type: By Homology

Follistatin
type: RnaRegionReference
comment: ENTITY_REFERENCE_NOTES=GeneID: 14313
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.Follistatin

PTHR24418:SF78
type: RelationshipXref
id: PTHR24418:SF78
db: PANTHER Family
relationship type: By Homology

uniprot P39654 76
type: UnificationXref
id: P39654
db: uniprot

UNKNOWN_TRANSITION_LEFT__PKA-RIGHT__CREB-_re529
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re529 892
participant stoichiometry: PARTICIPANT STOICHIOMETRY re529 893
left: PKA
interaction type: UNKNOWN_TRANSITION
right: CREB

integrin-ECM_FAK
type: Complex
component stoichiometry: FAK s812 sa684 STOICHIOMETRY ID COMPLEX
component stoichiometry: ECM alpha beta integrin dimer s814 csa52 STOICHIOMETRY ID COMPLEX
component: FAK
component: ECM_alpha-beta integrin dimer
feature: COMPLEX BINDING FEATURE s813 csa59 434
feature: COMPLEX BINDING FEATURE s813 csa59 436
cellular location: Cytoplasm

BMP2 4 15 s297 sa255 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP2/4/15
stoichiometric coefficient: 1.0

PTHR24070:SF385
type: RelationshipXref
id: PTHR24070:SF385
db: PANTHER Family
relationship type: By Homology

SMAD2 4 s683 sa339 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMAD2-4
stoichiometric coefficient: 1.0

TRANSLATION_LEFT__Fosb-RIGHT__FOS-_re438
type: TemplateReaction
product: FOS
xref: TRANSLATION
participant: FOS
participant: Fosb
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

SP1
type: ProteinReference
xref: P06846
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 20683 PMID: 19666697 Electrophoretic mobility shift assays showed Sp1/Sp3 proteins form major complexes within this region of the Nppc promoter. PMID: 10935547 The data suggest that the Sp1, SF-1, and Egr-1 binding sites form a tripartite GnRH response element in the rat LHbeta gene promoter. PMID: 11682622 This study shows that SP1 binds to the proximal and distal promoter regions of LHb promoter. DHT treatment reduces LHb promoter activity by 75% and is dependent on functional AR. AR directly interacts with SP1 where the interaction reduces SP1 binding to LHb promoter.
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.SP1
member entity reference: Transcription factor Sp1

PTHR23351:SF23
type: RelationshipXref
id: PTHR23351:SF23
db: PANTHER Family
relationship type: By Homology

GnRH GnRHR s805 csa57 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GnRH_GnRHR
stoichiometric coefficient: 1.0

Follistatin
type: RnaRegion
entity reference: Follistatin
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot P01101 96
organism: Mus musculus

Isl-1
type: RnaRegion
entity reference: Isl-1
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

MIS
type: ProteinReference
xref: P06750
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.MIS
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= GeneID: 11705
member entity reference: Muellerian-inhibiting factor

TRANSCRIPTION_LEFT__AK006051-RIGHT__miR_132_212-_re533
type: TemplateReaction
product: miR-132/212
xref: TRANSCRIPTION
participant: miR-132/212
participant: AK006051
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PARTICIPANT STOICHIOMETRY re283 592
type: Stoichiometry
physical entity: FOS_JUN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re283 593
type: Stoichiometry
physical entity: FOS_Jund
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re283 591
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

uniprot Q8K592 109
type: UnificationXref
id: Q8K592
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot Q91Y86 125
organism: Mus musculus

PTHR24347:SF403
type: RelationshipXref
id: PTHR24347:SF403
db: PANTHER Family
relationship type: By Homology

TRANSCRIPTION_LEFT__Zeb1-RIGHT__Zeb1-_re290
type: TemplateReaction
product: Zeb1
xref: TRANSCRIPTION
participant: Zeb1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PARTICIPANT STOICHIOMETRY re562 831
type: Stoichiometry
physical entity: Csda
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re562 832
type: Stoichiometry
physical entity: EGR1
stoichiometric coefficient: 1.0

alpha-beta integrin dimer
type: ProteinReference
xref: P06820
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.alpha-beta integrin dimer
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
comment: ENTITY_REFERENCE_NOTES= Itga1: GeneID: 109700 ; Itgb1: GeneID: 16412
member entity reference: Integrin beta-1
member entity reference: Integrin alpha-1

PARTICIPANT STOICHIOMETRY re562 833
type: Stoichiometry
physical entity: EGR1_Csda
stoichiometric coefficient: 1.0

ERK1/2
type: Protein
entity reference: ERK1/2
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P35569 182
type: UnificationXref
id: P35569
db: uniprot

Junc
type: DnaRegion
entity reference: Junc
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

PTHR24418:SF94
type: RelationshipXref
id: PTHR24418:SF94
db: PANTHER Family
relationship type: By Homology

Progonadoliberin-1
type: ProteinReference
xref: uniprot P13562 53
organism: Mus musculus

PGs
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s629 sa562 289
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR24055:SF109
type: RelationshipXref
id: PTHR24055:SF109
db: PANTHER Family
relationship type: By Homology

PTHR24055:SF107
type: RelationshipXref
id: PTHR24055:SF107
db: PANTHER Family
relationship type: By Homology

uniprot P23359 61
type: UnificationXref
id: P23359
db: uniprot

Prep1
type: Protein
entity reference: Prep1
feature: COMPLEX PARTICIPANT BINDING FEATURE s138 sa198 453
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

TRANSLATION_LEFT__EGR1-RIGHT__EGR1-_re457
type: TemplateReaction
product: EGR1
xref: TRANSLATION
participant: EGR1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

Nur77 s745 sa667 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Nur77
stoichiometric coefficient: 1.0

FAK s871 sa700 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

ELK1_SRF
type: Complex
component stoichiometry: SRF s676 sa609 STOICHIOMETRY ID COMPLEX
component stoichiometry: ELK1 s678 sa611 STOICHIOMETRY ID COMPLEX
component: SRF
component: ELK1
feature: COMPLEX BINDING FEATURE s752 csa23 480
feature: COMPLEX BINDING FEATURE s752 csa23 482
cellular location: Nucleus

uniprot Q8BJW6 14
type: UnificationXref
id: Q8BJW6
db: uniprot

Zeb1
type: DnaRegion
entity reference: Zeb1
feature: Zeb1 s323 sa246 tr1
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

DAG
type: SmallMolecule
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re491 889
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

uniprot P68404 27
type: UnificationXref
id: P68404
db: uniprot

TRANSLATION_LEFT__Atf3-RIGHT__Atf3-_re581
type: TemplateReaction
product: Atf3
xref: TRANSLATION
participant: Atf3
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

DUSP1
type: ProteinReference
xref: P06823
comment: ENTITY_REFERENCE_NOTES=GeneID: 19252
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.DUSP1
member entity reference: Dual specificity protein phosphatase 1

STATE_TRANSITION_LEFT__Junc-RIGHT__GnRHR-_re621
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re621 736
participant stoichiometry: PARTICIPANT STOICHIOMETRY re621 737
left: Junc
interaction type: STATE_TRANSITION
right: GnRHR

uniprot Q9Z0J4 100
type: UnificationXref
id: Q9Z0J4
db: uniprot

Glut1
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.Glut1
comment: ENTITY_REFERENCE_NOTES=GeneID: 20525

UNKNOWN_TRANSITION_LEFT__Linoleate-RIGHT__PKCe_theta-_re558
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re558 842
participant stoichiometry: PARTICIPANT STOICHIOMETRY re558 843
left: Linoleate
interaction type: UNKNOWN_TRANSITION
right: PKCe/theta

STATE_TRANSITION_LEFT__cAMP-RIGHT__PKA-_re44
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re44 713
participant stoichiometry: PARTICIPANT STOICHIOMETRY re44 712
left: cAMP
interaction type: STATE_TRANSITION
right: PKA

FOS
type: Protein
entity reference: FOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s599 sa506 331
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

Transcription factor 7
type: ProteinReference
xref: uniprot Q00417 70
organism: Mus musculus

STATE_TRANSITION
type: Control
xref: STATE TRANSITION
controlled: Translation attenuation of LHbeta and CGA mRNAs
controller: EIF2A

alpha beta integrin dimer s815 sa671 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha-beta integrin dimer
stoichiometric coefficient: 2.0

PTHR11462:SF8
type: RelationshipXref
id: PTHR11462:SF8
db: PANTHER Family
relationship type: By Homology

PTHR11462:SF7
type: RelationshipXref
id: PTHR11462:SF7
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re204 825
type: Stoichiometry
physical entity: MISRII
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re204 826
type: Stoichiometry
physical entity: 3' LHbeta
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PLD-RIGHT__PE-_PA-_re364
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re364 532
participant stoichiometry: PARTICIPANT STOICHIOMETRY re364 531
participant stoichiometry: PARTICIPANT STOICHIOMETRY re364 530
left: PLD
interaction type: STATE_TRANSITION
right: PE
right: PA

PARTICIPANT STOICHIOMETRY re491 888
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PKCs-RIGHT__Ras-_re475
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re475 929
participant stoichiometry: PARTICIPANT STOICHIOMETRY re475 928
left: PKCs
interaction type: STATE_TRANSITION
right: Ras

Annexin A5
type: RnaRegion
entity reference: Annexin A5
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

Cytochrome c oxidase subunit 2
type: DnaReference
organism: Mus musculus

uniprot Q68ED7 187
type: UnificationXref
id: Q68ED7
db: uniprot

PARTICIPANT STOICHIOMETRY re429 984
type: Stoichiometry
physical entity: GC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re429 985
type: Stoichiometry
physical entity: cGMP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MASH1-RIGHT__GnRHR-_re624
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re624 728
participant stoichiometry: PARTICIPANT STOICHIOMETRY re624 729
left: MASH1
interaction type: STATE_TRANSITION
right: GnRHR

STATE_TRANSITION_LEFT__CREB-RIGHT__Follistatin-_re598
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re598 698
participant stoichiometry: PARTICIPANT STOICHIOMETRY re598 697
left: CREB
interaction type: STATE_TRANSITION
right: Follistatin

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P26450 124
organism: Mus musculus

Adiponectin
type: ProteinReference
xref: uniprot Q60994 12
organism: Mus musculus

Cell migration
type: Pathway

SMAD1 5 8 s689 sa619 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.39269908169872414

PTHR45879:SF1
type: RelationshipXref
id: PTHR45879:SF1
db: PANTHER Family
relationship type: By Homology

Ggamma s620 sa553 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

Paxillin s868 sa697 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

Pyk2_SRC_Grb2_Sos
type: Complex
component stoichiometry: SRC s496 sa511 STOICHIOMETRY ID COMPLEX
component stoichiometry: Sos s497 sa514 STOICHIOMETRY ID COMPLEX
component stoichiometry: Grb2 s495 sa513 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pyk2 s494 sa512 STOICHIOMETRY ID COMPLEX
component: Pyk2
component: Grb2
component: Sos
component: SRC
feature: COMPLEX BINDING FEATURE s749 csa18 404
feature: COMPLEX BINDING FEATURE s749 csa18 408
feature: COMPLEX BINDING FEATURE s749 csa18 410
feature: COMPLEX BINDING FEATURE s749 csa18 406
cellular location: Cytoplasm

PARTICIPANT STOICHIOMETRY re529 892
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re529 893
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SMAD2_4-RIGHT__SMAD2_4-_re551
controller: BMPR-IA/IB/II

gnai o s163 sa219 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: gnai/o
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__SMAD1_5_8-RIGHT__SMAD1_5_8-_re552
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re552 851
participant stoichiometry: PARTICIPANT STOICHIOMETRY re552 850
left: SMAD1/5/8
interaction type: STATE_TRANSITION
right: SMAD1/5/8

STATE_TRANSITION_LEFT__ER-RIGHT__Zeb1-_re606
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re606 809
participant stoichiometry: PARTICIPANT STOICHIOMETRY re606 810
left: ER
interaction type: STATE_TRANSITION
right: Zeb1

RICS
type: RnaRegion
entity reference: RICS
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

PTHR10159:SF309
type: RelationshipXref
id: PTHR10159:SF309
db: PANTHER Family
relationship type: By Homology

UNKNOWN_TRANSITION_LEFT__L_type_Ca2_PLUS_-RIGHT__Ras-_re482
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re482 916
participant stoichiometry: PARTICIPANT STOICHIOMETRY re482 917
left: L-type Ca2+
interaction type: UNKNOWN_TRANSITION
right: Ras

STATE_TRANSITION_LEFT__GATA2_4-RIGHT__3_QUOTE_SINGLE_LHbeta-_re626
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re626 725
participant stoichiometry: PARTICIPANT STOICHIOMETRY re626 724
left: GATA2/4
interaction type: STATE_TRANSITION
right: 3' LHbeta

UNKNOWN_TRANSITION_LEFT__ERK1_2-RIGHT__Annexin_A5-_re299
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re299 568
participant stoichiometry: PARTICIPANT STOICHIOMETRY re299 567
left: ERK1/2
interaction type: UNKNOWN_TRANSITION
right: Annexin A5

uniprot P81122 183
type: UnificationXref
id: P81122
db: uniprot

UNKNOWN_TRANSITION_LEFT__PKCs-RIGHT__SRC-_re527
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re527 894
participant stoichiometry: PARTICIPANT STOICHIOMETRY re527 895
left: PKCs
interaction type: UNKNOWN_TRANSITION
right: SRC

uniprot P27038 44
type: UnificationXref
id: P27038
db: uniprot

PTHR24055:SF110
type: RelationshipXref
id: PTHR24055:SF110
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot Q9WTU6 126
xref: PTHR24055:SF172
organism: Mus musculus

PTHR24418:SF53
type: RelationshipXref
id: PTHR24418:SF53
db: PANTHER Family
relationship type: By Homology

Pro-epidermal growth factor
type: ProteinReference
xref: uniprot P01132 175
organism: Mus musculus

Integrin beta-1
type: ProteinReference
xref: PTHR10082:SF28
xref: uniprot P09055 136
organism: Mus musculus

BMP7
type: RnaRegionReference
comment: ENTITY_REFERENCE_NOTES=GeneID: 12162
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.BMP7

PARTICIPANT STOICHIOMETRY re590 709
type: Stoichiometry
physical entity: TORC1
stoichiometric coefficient: 1.0

ELK1
type: ProteinReference
xref: P06785
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.ELK1
comment: ENTITY_REFERENCE_NOTES= GeneID: 13712
member entity reference: ETS domain-containing protein Elk-1

PTHR45673:SF5
type: RelationshipXref
id: PTHR45673:SF5
db: PANTHER Family
relationship type: By Homology

NOSI
type: ProteinReference
xref: P06741
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.NOSI
comment: ENTITY_REFERENCE_NOTES=GeneID: 18125 NOSI=neuronal Nitric Oxide Synthase type I
member entity reference: Nitric oxide synthase, brain

STATE_TRANSITION
type: Control
xref: STATE TRANSITION
controlled: LH secretion
controller: LHbeta

DGK zeta s336 sa346 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DGK-zeta
stoichiometric coefficient: 1.0

PTHR24055:SF146
type: RelationshipXref
id: PTHR24055:SF146
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re424 993
type: Stoichiometry
physical entity: MAP2K1/2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__p65_p65-RIGHT__COX2-_re604
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re604 813
participant stoichiometry: PARTICIPANT STOICHIOMETRY re604 814
left: p65_p65
interaction type: STATE_TRANSITION
right: COX2

PTHR45628:SF9
type: RelationshipXref
id: PTHR45628:SF9
db: PANTHER Family
relationship type: By Homology

PRLR s381 sa396 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PRLR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re424 992
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

PTHR45628:SF2
type: RelationshipXref
id: PTHR45628:SF2
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re387 1000
type: Stoichiometry
physical entity: JNK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re387 1001
type: Stoichiometry
physical entity: 3' FSHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re590 710
type: Stoichiometry
physical entity: Nur77
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re590 711
type: Stoichiometry
physical entity: Nur77_TORC1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PI3K-RIGHT__AKT-_re301
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re301 622
participant stoichiometry: PARTICIPANT STOICHIOMETRY re301 621
left: PI3K
interaction type: STATE_TRANSITION
right: AKT

STATE_TRANSITION_LEFT__JAK1-RIGHT__STAT3-_re521
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re521 901
participant stoichiometry: PARTICIPANT STOICHIOMETRY re521 900
left: JAK1
interaction type: STATE_TRANSITION
right: STAT3

STATE_TRANSITION_LEFT__AC-RIGHT__cAMP-_re43
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 714
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 715
left: AC
interaction type: STATE_TRANSITION
right: cAMP

PARTICIPANT STOICHIOMETRY re597 699
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PKA-RIGHT__CREB-_re315
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re315 603
participant stoichiometry: PARTICIPANT STOICHIOMETRY re315 602
left: PKA
interaction type: STATE_TRANSITION
right: CREB

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__TBRIII-RIGHT__Inhba_b-_re442
control type: INHIBITION
controller: TGFbeta

STATE_TRANSITION_LEFT__p65_p65-RIGHT__COX2-_re605
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re605 812
participant stoichiometry: PARTICIPANT STOICHIOMETRY re605 811
left: p65_p65
interaction type: STATE_TRANSITION
right: COX2

Caveolin 1 s855 sa525 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Caveolin-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re227 746
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

POU domain, class 2, transcription factor 1
type: ProteinReference
xref: uniprot P25425 63
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re227 747
type: Stoichiometry
physical entity: 5' FSHbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re589 734
type: Stoichiometry
physical entity: TORC1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re589 735
type: Stoichiometry
physical entity: CGA
stoichiometric coefficient: 1.0

BMP7
type: DnaRegion
entity reference: BMP7
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

STATE_TRANSITION_LEFT__Rac1-RIGHT__MAP4Ks-_re593
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re593 704
participant stoichiometry: PARTICIPANT STOICHIOMETRY re593 703
left: Rac1
interaction type: STATE_TRANSITION
right: MAP4Ks

Matrix metalloproteinase-14
type: ProteinReference
xref: uniprot P53690 167
xref: PTHR10201:SF24
organism: Mus musculus

AC
type: Protein
entity reference: AC
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Rap1b
type: DnaRegion
entity reference: Rap1b
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: PTHR24361:SF656
xref: uniprot Q61084 161
organism: Mus musculus

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot Q61083 160
xref: PTHR24361:SF342
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re394 979
type: Stoichiometry
physical entity: Follistatin
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Junc-RIGHT__5_QUOTE_SINGLE_LHbeta-_re629
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re629 719
participant stoichiometry: PARTICIPANT STOICHIOMETRY re629 718
left: Junc
interaction type: STATE_TRANSITION
right: 5' LHbeta

PITX
type: Protein
entity reference: PITX
feature: COMPLEX PARTICIPANT BINDING FEATURE s385 sa404 513
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__MAP3Ks-RIGHT__MKK3_6-_re319
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re319 596
participant stoichiometry: PARTICIPANT STOICHIOMETRY re319 597
left: MAP3Ks
interaction type: STATE_TRANSITION
right: MKK3/6

CNP
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.CNP
comment: ENTITY_REFERENCE_NOTES=Nppc: GeneID: 18159

PARTICIPANT STOICHIOMETRY re394 978
type: Stoichiometry
physical entity: PPARalpha/gamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re504 937
type: Stoichiometry
physical entity: CGA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re504 936
type: Stoichiometry
physical entity: Alk4_ActivinA_ActRII/IIB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re625 726
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re325 577
type: Stoichiometry
physical entity: ERK1/2
stoichiometric coefficient: 1.0

Vinculin
type: Protein
entity reference: Vinculin
feature: COMPLEX PARTICIPANT BINDING FEATURE s854 sa524 311
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re325 578
type: Stoichiometry
physical entity: Follistatin
stoichiometric coefficient: 1.0

Inha
type: ProteinReference
xref: P06855
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= GeneID: 16322
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Inha
member entity reference: Inhibin alpha chain

UNKNOWN_TRANSITION_LEFT__ERK1_2-RIGHT__JUN-_re213
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re213 790
participant stoichiometry: PARTICIPANT STOICHIOMETRY re213 789
left: ERK1/2
interaction type: UNKNOWN_TRANSITION
right: JUN

uniprot P41778 62
type: UnificationXref
id: P41778
db: uniprot

Jund
type: Protein
entity reference: Jund
feature: COMPLEX PARTICIPANT BINDING FEATURE s481 sa507 383
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Alk4_ActivinA_ActRII_IIB-RIGHT__Pbx1-_re335
control type: INHIBITION
controller: NOSI

3' LHbeta
type: DnaRegionReference
member entity reference: Lutropin subunit beta
xref: G06903
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.3' LHbeta
comment: ENTITY_REFERENCE_NOTES=GeneID: 16866

Isl-1
type: DnaRegion
entity reference: Isl-1
feature: Isl 1 s643 sa572 tr1
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

uniprot Q63932 43
type: UnificationXref
id: Q63932
db: uniprot

5-hydroxytryptamine receptor 3A
type: ProteinReference
xref: uniprot P23979 55
xref: PTHR18945:SF52
organism: Mus musculus

SRF s676 sa609 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SRF
stoichiometric coefficient: 1.0

PTHR48012:SF19
type: RelationshipXref
id: PTHR48012:SF19
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__ERK1_2-RIGHT__ERK1_2-_re113
controller: PKCs

Inhibin alpha chain
type: ProteinReference
xref: uniprot Q04997 205
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re317 600
type: Stoichiometry
physical entity: Cdc42
stoichiometric coefficient: 1.0

Inhibin beta B chain
type: ProteinReference
xref: uniprot Q04999 128
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re317 601
type: Stoichiometry
physical entity: MAP4Ks
stoichiometric coefficient: 1.0

Inhibin beta A chain
type: ProteinReference
xref: uniprot Q04998 127
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re625 727
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

Inhba
type: ProteinReference
xref: P06723
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Inhba
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= GeneID: 16323
member entity reference: Inhibin beta A chain

CBP s740 sa662 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.39269908169872414

PTHR10373:SF25
type: RelationshipXref
id: PTHR10373:SF25
db: PANTHER Family
relationship type: By Homology

SMAD2 4 s682 sa614 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.39269908169872414

Insulin s193 sa252 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Insulin
stoichiometric coefficient: 1.0

uniprot O08911 84
type: UnificationXref
id: O08911
db: uniprot

uniprot P34152 149
type: UnificationXref
id: P34152
db: uniprot

GnRHR
type: DnaRegion
entity reference: GnRHR
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

CBP
type: Protein
entity reference: CBP
feature: CBP s741 sa661 rs1
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

PTHR24055:SF172
type: RelationshipXref
id: PTHR24055:SF172
db: PANTHER Family
relationship type: By Homology

BMP6 7 s687 sa617 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP6/7
stoichiometric coefficient: 1.0

GnRH
type: Protein
entity reference: GnRH
feature: COMPLEX PARTICIPANT BINDING FEATURE s879 sa709 479
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

Tubulin alpha-1B chain
type: ProteinReference
xref: uniprot P05213 130
organism: Mus musculus

uniprot P23979 55
type: UnificationXref
id: P23979
db: uniprot

TRANSLATION_LEFT__Zeb1-RIGHT__Zeb1-_re414
type: TemplateReaction
product: Zeb1
xref: TRANSLATION
participant: Zeb1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

Kinase suppressor of Ras 1
type: ProteinReference
xref: uniprot Q61097 222
organism: Mus musculus

uniprot P61168 245
type: UnificationXref
id: P61168
db: uniprot

P06709
type: UnificationXref
id: P06709
db: PANTHER Pathway Component

uniprot Q9Z0Y7 184
type: UnificationXref
id: Q9Z0Y7
db: uniprot

CREB-binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot P45481 244
organism: Mus musculus

P06707
type: UnificationXref
id: P06707
db: PANTHER Pathway Component

P06708
type: UnificationXref
id: P06708
db: PANTHER Pathway Component

P06705
type: UnificationXref
id: P06705
db: PANTHER Pathway Component

UNKNOWN_TRANSITION_LEFT__ERK1_2-RIGHT__Follistatin-_re325
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re325 578
participant stoichiometry: PARTICIPANT STOICHIOMETRY re325 577
left: ERK1/2
interaction type: UNKNOWN_TRANSITION
right: Follistatin

uniprot P37238 89
type: UnificationXref
id: P37238
db: uniprot

P06706
type: UnificationXref
id: P06706
db: PANTHER Pathway Component

uniprot P53349 154
type: UnificationXref
id: P53349
db: uniprot

PR
type: ProteinReference
xref: P06708
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 18667 PMID: 16675544 This study uses overexpression of the PR in order to show regulation of the FSHb promoter. This does not necessarily provide evidence of endogenous responsiveness to progesterone. PMID: 18079204 This study shows that PR interacts with smad2/3/4 in vitro, and progesterone and activin act synergistically to induce FSHb promoter activity when PR is overexpressed. PMID: 19106225 This study shows that progesterone reduces LHb inducibility by GnRH. By progesterone treatment, progesterone receptor binds to the PRE sites of LHb promoter and blocks LHb promoter activity. Both dominant negative of PR and deletion of PRE site block progesterone mediated LHb inhibition.
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PR
member entity reference: Progesterone receptor

P06703
type: UnificationXref
id: P06703
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__SRC-RIGHT__Ras-_re480
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re480 918
participant stoichiometry: PARTICIPANT STOICHIOMETRY re480 919
left: SRC
interaction type: STATE_TRANSITION
right: Ras

P06704
type: UnificationXref
id: P06704
db: PANTHER Pathway Component

uniprot Q60751 234
type: UnificationXref
id: Q60751
db: uniprot

Prostacyclin receptor
type: ProteinReference
xref: uniprot P43252 146
organism: Mus musculus

PTHR13808:SF34
type: RelationshipXref
id: PTHR13808:SF34
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re12 839
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

Glut1
type: DnaRegion
entity reference: Glut1
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

PARTICIPANT STOICHIOMETRY re12 838
type: Stoichiometry
physical entity: Pyk2_SRC_Grb2_Sos
stoichiometric coefficient: 1.0

JUN
type: Protein
entity reference: JUN
feature: COMPLEX PARTICIPANT BINDING FEATURE s152 sa212 349
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q01776 151
type: UnificationXref
id: Q01776
db: uniprot

uniprot P27106 80
type: UnificationXref
id: P27106
db: uniprot

P06713
type: UnificationXref
id: P06713
db: PANTHER Pathway Component

P06712
type: UnificationXref
id: P06712
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re479 922
type: Stoichiometry
physical entity: alpha-beta integrin dimer
stoichiometric coefficient: 2.0

P06711
type: UnificationXref
id: P06711
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re479 923
type: Stoichiometry
physical entity: Pyk2_SRC_Grb2_Sos
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: InteractionVocabulary

P06710
type: UnificationXref
id: P06710
db: PANTHER Pathway Component

TRANSPORT
type: InteractionVocabulary

Y-box-binding protein 3
type: ProteinReference
xref: uniprot Q9JKB3 67
organism: Mus musculus

SMAD2 4 s595 sa342 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMAD2-4
stoichiometric coefficient: 1.0

P06719
type: UnificationXref
id: P06719
db: PANTHER Pathway Component

P06715
type: UnificationXref
id: P06715
db: PANTHER Pathway Component

P06716
type: UnificationXref
id: P06716
db: PANTHER Pathway Component

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s619 sa552 379
cellular location: Nucleus
comment: SPECIES_TYPE=PROTEIN

P06717
type: UnificationXref
id: P06717
db: PANTHER Pathway Component

ER
type: ProteinReference
xref: P06851
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.ER
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 26379
member entity reference: Steroid hormone receptor ERR1

alpha-beta integrin dimer
type: Protein
entity reference: alpha-beta integrin dimer

PTHR13808:SF29
type: RelationshipXref
id: PTHR13808:SF29
db: PANTHER Family
relationship type: By Homology

UNKNOWN_TRANSITION_LEFT__PKCs-RIGHT__CREB-_re282
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re282 595
participant stoichiometry: PARTICIPANT STOICHIOMETRY re282 594
left: PKCs
interaction type: UNKNOWN_TRANSITION
right: CREB

GR
type: ProteinReference
xref: P06810
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=GeneID: 14815
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.GR
member entity reference: Glucocorticoid receptor

uniprot P47713 230
type: UnificationXref
id: P47713
db: uniprot

UNKNOWN_TRANSITION
type: Control
xref: UNKNOWN TRANSITION
controlled: LH secretion
controller: PRLR

PARTICIPANT STOICHIOMETRY re521 901
type: Stoichiometry
physical entity: STAT3
stoichiometric coefficient: 1.0

P06722
type: UnificationXref
id: P06722
db: PANTHER Pathway Component

KSR-1
type: Protein
entity reference: KSR-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s872 sa701 465
cellular location: Cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re521 900
type: Stoichiometry
physical entity: JAK1
stoichiometric coefficient: 1.0

P06721
type: UnificationXref
id: P06721
db: PANTHER Pathway Component

P06724
type: UnificationXref
id: P06724
db: PANTHER Pathway Component

uniprot P36898 122
type: UnificationXref
id: P36898
db: uniprot

Id2
type: ProteinReference
xref: P06804
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Id2
comment: ENTITY_REFERENCE_NOTES= GeneID: 15902
member entity reference: DNA-binding protein inhibitor ID-2

P06723
type: UnificationXref
id: P06723
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re361 537
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

P06720
type: UnificationXref
id: P06720
db: PANTHER Pathway Component

PKCs(3)
type: ProteinReference
xref: P06850
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PKCs(3)
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= protein kinase C, alpha: GeneID: 18750 ; protein kinase C, delta: GeneID: 18753 ; protein kinase C, epsilon: GeneID: 18754
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C alpha type
member entity reference: Protein kinase C delta type

PARTICIPANT STOICHIOMETRY re361 538
type: Stoichiometry
physical entity: nPKCs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re20 799
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

Cytochrome c oxidase subunit 2
type: ProteinReference
xref: uniprot P00405 190
organism: Mus musculus

Insulin receptor substrate 1
type: ProteinReference
xref: uniprot P35569 182
xref: PTHR10614:SF11
organism: Mus musculus

Paxillin
type: ProteinReference
xref: PTHR24216:SF11
xref: uniprot Q8VI36 99
organism: Mus musculus

GnRHR
type: RnaRegion
entity reference: GnRHR
cellular location: Nucleus
comment: SPECIES_TYPE=RNA

MASH1
type: ProteinReference
xref: P06826
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.MASH1
comment: ENTITY_REFERENCE_NOTES=GeneID: 17172 PMID:18760324 This study shows that MASH1 binds to E-box site on the GnRHR promoter in LbT2 cells. It is shown that mutation at E-box reduces GnRHR expression.
member entity reference: Achaete-scute homolog 1

COX2
type: DnaRegion
entity reference: COX2
cellular location: Nucleus
comment: SPECIES_TYPE=GENE

PARTICIPANT STOICHIOMETRY re584 755
type: Stoichiometry
physical entity: Junc
stoichiometric coefficient: 1.0

cGMP
type: SmallMolecule
cellular location: Cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re584 754
type: Stoichiometry
physical entity: NFAT
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__SP1-RIGHT__5_QUOTE_SINGLE_LHbeta-_re632
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re632 692
participant stoichiometry: PARTICIPANT STOICHIOMETRY re632 691
left: SP1
interaction type: STATE_TRANSITION
right: 5' LHbeta

LHbeta
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.LHbeta
comment: ENTITY_REFERENCE_NOTES=GeneID: 16866

Sos
type: ProteinReference
xref: P06849
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Sos
comment: ENTITY_REFERENCE_NOTES= Sos1: GeneID: 20662; Sos2: GeneID: 20663
member entity reference: Son of sevenless homolog 2
member entity reference: Son of sevenless homolog 1

GnRHR s878 sa707 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GnRHR
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MT1_MMP-RIGHT__EGFR-_re396
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re396 975
participant stoichiometry: PARTICIPANT STOICHIOMETRY re396 974
left: MT1-MMP
interaction type: STATE_TRANSITION
right: EGFR

Guanylate cyclase 1, soluble, beta 2
type: ProteinReference
xref: uniprot Q8BXH3 78
organism: Mus musculus

uniprot O09100 118
type: UnificationXref
id: O09100
db: uniprot

5'-AMP-activated protein kinase subunit beta-1
type: ProteinReference
xref: uniprot Q9R078 221
organism: Mus musculus

Eukaryotic translation initiation factor 2A
type: ProteinReference
xref: uniprot Q8BJW6 14
organism: Mus musculus

P06700
type: UnificationXref
id: P06700
db: PANTHER Pathway Component

PTHR11462:SF37
type: RelationshipXref
id: PTHR11462:SF37
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Junc-RIGHT__CGA-_re658
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re658 634
participant stoichiometry: PARTICIPANT STOICHIOMETRY re658 633
left: Junc
interaction type: STATE_TRANSITION
right: CGA

P06702
type: UnificationXref
id: P06702
db: PANTHER Pathway Component

P06701
type: UnificationXref
id: P06701
db: PANTHER Pathway Component