Casein kinase I isoform alpha
type: ProteinReference
xref: uniprot P54367 30
xref: PTHR11909:SF20
organism: Drosophila melanogaster

uniprot Q8JHE0 38
type: UnificationXref
id: Q8JHE0
db: uniprot

Cubitus interruptus
type: Protein
entity reference: Cubitus interruptus
feature: Cubitus interruptus s42 sa22 rs2
feature: Cubitus interruptus s42 sa22 rs1
feature: Cubitus interruptus s42 sa22 rs3
feature: Cubitus interruptus s42 sa22 rs4
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa22 246
cellular location: membrane raft
comment: SPECIES_TYPE=PROTEIN

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 3

Slimb s29 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Slimb
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CC58 97
xref: PTHR44156:SF2
organism: Monodelphis domestica

Casein kinase 1 epsilon
type: ProteinReference
xref: uniprot Q5XGI6 35
xref: PTHR11909:SF18
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5NXE7 86
xref: PTHR44129:SF4
organism: Gallus gallus

uniprot F7E905 157
type: UnificationXref
id: F7E905
db: uniprot

uniprot P19538 150
type: UnificationXref
id: P19538
db: uniprot

uniprot A0A1D5RFU7 194
type: UnificationXref
id: A0A1D5RFU7
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 37

uniprot F1PNE0 127
type: UnificationXref
id: F1PNE0
db: uniprot

Hedgehog signaling pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Complex__Costal2_Fused__Smoothened_-_ATP-RIGHT__Complex__Costal2_Smoothened__Fused_-_ADP-_r15
pathway component: DISSOCIATION_LEFT__Complex__Costal2_Fused__Su_fu__Cubitus_interruptus__Smoothened_MIcrotubule_-RIGHT__Microtubule-_Complex__Su_fu__Fused__Cubitus_interruptus_Costal2__Smoothened_-_r23
pathway component: TRANSPORT_LEFT__Complex__Su_fu__Cubitus_interruptus_-RIGHT__Cubitus_interruptus-_r56
pathway component: STATE_TRANSITION_LEFT__Cubitus_interruptus-RIGHT__Cubitus_interruptus-_r53
pathway component: STATE_TRANSITION_LEFT__Complex__Patched_Hedgehog_-RIGHT__a31_degraded-_r10
pathway component: TRANSPORT_LEFT__Complex__Cubitus_interruptus_repressor_Su_fu__-RIGHT__Complex__Cubitus_interruptus_repressor_Su_fu__-_r42
pathway component: STATE_TRANSITION_LEFT__Complex__Su_fu__Slimb__Cubitus_interruptus_-RIGHT__Complex__Cubitus_interruptus_repressor_Su_fu__-_r41
pathway component: HETERODIMER_ASSOCIATION_LEFT__CBP-_Cubitus_interruptus-RIGHT__Complex__CBP_Cubitus_interruptus_-_r54
pathway component: TRANSPORT_LEFT__Complex__Su_fu__Cubitus_interruptus_-RIGHT__Cubitus_interruptus-_r26
pathway component: STATE_TRANSITION_LEFT__Complex__Su_fu__Cubitus_interruptus_-_ATP-RIGHT__ADP-_Complex__Su_fu__Cubitus_interruptus_-_r29
pathway component: HETERODIMER_ASSOCIATION_LEFT__Patched-_Hedgehog-RIGHT__Complex__Patched_Hedgehog_-_r7
pathway component: STATE_TRANSITION_LEFT__Debra-RIGHT__Debra-_re25
pathway component: TRANSCRIPTION_LEFT__Hedgehog_target_gene-RIGHT__Hedgehog_target_gene-_re24
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__Complex__Costal2_Fused__Su_fu__Cubitus_interruptus__Smoothened_MIcrotubule_-RIGHT__Complex__Su_fu__Cubitus_interruptus_-_r48
pathway component: DISSOCIATION_LEFT__Complex__Su_fu__Fused__Cubitus_interruptus_Costal2__Smoothened_-RIGHT__Complex__Su_fu__Cubitus_interruptus_-_Complex__Costal2_Fused__Smoothened_-_r25
pathway component: STATE_TRANSITION_LEFT__Complex__Su_fu__Cubitus_interruptus_-_ATP-RIGHT__Complex__Su_fu__Cubitus_interruptus_-_ADP-_r30
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Cubitus_interruptus_repressor_Su_fu__-_Sap18-RIGHT__Complex__Sap18_Su_fu___Cubitus_interruptus_repressor_-_r51
pathway component: STATE_TRANSITION_LEFT__Complex__Cubitus_interruptus_Su_fu___Slimb_-_Ubiquitin-RIGHT__Complex__Su_fu__Slimb__Cubitus_interruptus_-_r40
pathway component: TRANSPORT_LEFT__Complex__Costal2_Fused__Smoothened_-RIGHT__Complex__Costal2_Fused__Smoothened_-_r14
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Su_fu__Cubitus_interruptus_-_Slimb-RIGHT__Complex__Cubitus_interruptus_Su_fu___Slimb_-_r38
pathway component: TRANSPORT_LEFT__Complex__Patched_Hedgehog_-RIGHT__Complex__Patched_Hedgehog_-_r8
pathway component: STATE_TRANSITION_LEFT__Cubitus_interruptus-RIGHT__a202_degraded-_r44
xref: PANTHER Pathway P00025 1
comment: MODEL_NOTES=Panther Pathway: P00025 This is the current model for the Hedgehog signaling pathway. The best data for mechanism of signaling has been worked out in Drosophila, so this model is based largely on Drosophila data. Hedgehog target genes vary from tissue to tissue, so the identities of individual target genes have not been listed. The main difference between the Drosophila and mammalian Hedgehog signaling pathways is the fact that there are three mammalian homologs of Cubitus interruptus, Gli1 Gli2 and Gli3. Some or all of the mammalian homologs may be proteolytically processed, but the data are controversial. There are two mammalian Ptc genes and three mammalian Hedgehog genes as well. The pathway for Sonic Hedgehog appears to be most similar to the Drosophila hedgehog pathway. Medline=11731473 Medline=11861165 Medline=12200154 Medline=14738752 PMID: 11731473 PMID: 11861165 PMID: 12200154 PMID: 14738752

uniprot O76324 24
type: UnificationXref
id: O76324
db: uniprot

uniprot E1BE57 105
type: UnificationXref
id: E1BE57
db: uniprot

uniprot Q09540 131
type: UnificationXref
id: Q09540
db: uniprot

uniprot Q93372 173
type: UnificationXref
id: Q93372
db: uniprot

uniprot F7CC58 97
type: UnificationXref
id: F7CC58
db: uniprot

uniprot P00514 59
type: UnificationXref
id: P00514
db: uniprot

PARTICIPANT STOICHIOMETRY r41 326
type: Stoichiometry
physical entity: Complex (Su(fu)/Slimb/ Cubitus interruptus)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r41 327
type: Stoichiometry
physical entity: Complex (Cubitus interruptus repressor/Su(fu))
stoichiometric coefficient: 1.0

Fused s14 sa10 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot F7HAK5 53
type: UnificationXref
id: F7HAK5
db: uniprot

uniprot P16905 68
type: UnificationXref
id: P16905
db: uniprot

ncbitaxon 7227 25
type: UnificationXref
id: 7227
db: ncbitaxon

Cubitus interruptus repressor s149 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cubitus interruptus repressor
stoichiometric coefficient: 1.0

CBP
type: Protein
entity reference: CBP
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa46 206
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q15465 123
type: UnificationXref
id: Q15465
db: uniprot

GO GO:0045121 4
type: UnificationXref
id: GO:0045121
db: GO

PANTHER Pathway P00025 1
type: UnificationXref
id: P00025
db: PANTHER Pathway

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 76

PRKAR1A isoform 12
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot H2R3M7 54
organism: Pan troglodytes

Fused s8 sa6 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Protein patched homolog 1
type: ProteinReference
xref: PTHR46022:SF5
xref: uniprot Q61115 134
organism: Mus musculus

Su(fu)
type: Protein
entity reference: Su(fu)
feature: COMPLEX PARTICIPANT BINDING FEATURE s35 sa16 214
cellular location: membrane raft
comment: SPECIES_TYPE=PROTEIN

uniprot F1QAC4 142
type: UnificationXref
id: F1QAC4
db: uniprot

uniprot Q5ZM91 79
type: UnificationXref
id: Q5ZM91
db: uniprot

Zinc finger protein GLI1
type: ProteinReference
xref: uniprot P08151 148
organism: Homo sapiens

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 7

Su fu s52 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Su(fu)
stoichiometric coefficient: 1.0

uniprot O64644 188
type: UnificationXref
id: O64644
db: uniprot

uniprot Q7PYI0 199
type: UnificationXref
id: Q7PYI0
db: uniprot

uniprot P54367 30
type: UnificationXref
id: P54367
db: uniprot

uniprot E2RDC4 91
type: UnificationXref
id: E2RDC4
db: uniprot

uniprot F1P3J4 120
type: UnificationXref
id: F1P3J4
db: uniprot

Complex (Sap18/Su(fu)/ Cubitus interruptus repressor)
type: Complex
component stoichiometry: Su fu s54 sa44 STOICHIOMETRY ID COMPLEX
component stoichiometry: Sap18 s53 sa43 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cubitus interruptus repressor s151 sa45 STOICHIOMETRY ID COMPLEX
component: Cubitus interruptus repressor
component: Su(fu)
component: Sap18
feature: COMPLEX BINDING FEATURE s140 a222 237
feature: COMPLEX BINDING FEATURE s140 a222 235
feature: COMPLEX BINDING FEATURE s140 a222 239
cellular location: nucleus

uniprot F6VZ48 178
type: UnificationXref
id: F6VZ48
db: uniprot

STATE_TRANSITION_LEFT__Complex__Su_fu__Slimb__Cubitus_interruptus_-RIGHT__Complex__Cubitus_interruptus_repressor_Su_fu__-_r41
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 327
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 326
left: Complex (Su(fu)/Slimb/ Cubitus interruptus)
interaction type: STATE_TRANSITION
right: Complex (Cubitus interruptus repressor/Su(fu))

ncbitaxon 3702 189
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot P30625 69
type: UnificationXref
id: P30625
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Su_fu__Cubitus_interruptus_-_ATP-RIGHT__Complex__Su_fu__Cubitus_interruptus_-_ADP-_r30
controller: GSK3

Patched
type: Protein
entity reference: Patched
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HEG3 180
organism: Macaca mulatta

uniprot P49674 29
type: UnificationXref
id: P49674
db: uniprot

STATE_TRANSITION_LEFT__Complex__Su_fu__Cubitus_interruptus_-_ATP-RIGHT__ADP-_Complex__Su_fu__Cubitus_interruptus_-_r29
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 334
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 336
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 335
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 333
left: ATP
left: Complex (Su(fu)/Cubitus interruptus)
interaction type: STATE_TRANSITION
right: Complex (Su(fu)/Cubitus interruptus)
right: ADP

Su(fu)
type: Protein
entity reference: Su(fu)
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa31 280
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

GLI family zinc finger 1
type: ProteinReference
xref: uniprot G3V6X8 147
organism: Rattus norvegicus

Sap18
type: Protein
entity reference: Sap18
feature: COMPLEX PARTICIPANT BINDING FEATURE s53 sa43 236
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

By Homology
type: RelationshipTypeVocabulary

Cubitus interruptus repressor
type: Protein
entity reference: Cubitus interruptus repressor
feature: COMPLEX PARTICIPANT BINDING FEATURE s151 sa45 240
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Beta-transducin repeat-containing E3 ubiquitin protein ligase
type: ProteinReference
xref: PTHR14604:SF4
xref: uniprot F1LMH8 92
organism: Rattus norvegicus

Smoothened s13 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Smoothened
stoichiometric coefficient: 1.0

uniprot Q99835 112
type: UnificationXref
id: Q99835
db: uniprot

Costal2
type: Protein
entity reference: Costal2
feature: Costal2 s15 sa11 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa11 290
cellular location: membrane raft
comment: SPECIES_TYPE=PROTEIN

Casein kinase I isoform alpha
type: ProteinReference
xref: uniprot P97633 33
xref: PTHR11909:SF20
organism: Rattus norvegicus

Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot F1QEC8 47
organism: Danio rerio

ncbitaxon 9615 45
type: UnificationXref
id: 9615
db: ncbitaxon

Si:dkeyp-80c12.7
type: ProteinReference
xref: uniprot B8JIQ1 166
xref: PTHR24057:SF8
organism: Danio rerio

GLI1 protein
type: ProteinReference
xref: uniprot A6H727 139
organism: Bos taurus

uniprot F6RMT7 197
type: UnificationXref
id: F6RMT7
db: uniprot

Transcriptional activator cubitus interruptus
type: ProteinReference
xref: uniprot P19538 150
xref: PTHR45718:SF4
organism: Drosophila melanogaster

uniprot P10644 61
type: UnificationXref
id: P10644
db: uniprot

Casein kinase 1 alpha 1
type: ProteinReference
xref: uniprot F6VPH2 19
xref: PTHR11909:SF20
organism: Xenopus tropicalis

Su(fu)
type: Protein
entity reference: Su(fu)
feature: COMPLEX PARTICIPANT BINDING FEATURE s52 sa42 258
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Sap18
type: Protein
entity reference: Sap18
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Costal2
type: Protein
entity reference: Costal2
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa14 210
feature: Costal2 s33 sa14 rs1
cellular location: membrane raft
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5NXE7 86
type: UnificationXref
id: A0A1D5NXE7
db: uniprot

uniprot P49841 172
type: UnificationXref
id: P49841
db: uniprot

F-box and WD repeat domain-containing 11b
type: ProteinReference
xref: uniprot A0A2R8RWN9 89
xref: PTHR19854:SF16
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F6R812 17
xref: PTHR11909:SF20
organism: Monodelphis domestica

uniprot A8X4K1 164
type: UnificationXref
id: A8X4K1
db: uniprot

PTHR46276:SF1
type: RelationshipXref
id: PTHR46276:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q92008 124
type: UnificationXref
id: Q92008
db: uniprot

Su fu s24 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Su(fu)
stoichiometric coefficient: 1.0

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 16

00696
type: UnificationXref
id: MOD:00696
db: mod

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Cubitus_interruptus-RIGHT__Cubitus_interruptus-_r53
controller: Complex (Costal2/Smoothened/ Fused)

Su(fu)
type: Protein
entity reference: Su(fu)
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa36 266
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

Discs overgrown protein kinase
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot O76324 24
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E905 157
xref: PTHR13808:SF34
organism: Monodelphis domestica

uniprot F7HEG3 180
type: UnificationXref
id: F7HEG3
db: uniprot

uniprot F7GN18 145
type: UnificationXref
id: F7GN18
db: uniprot

ATP
type: SmallMolecule
cellular location: Receiving cell c1
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Debra
type: Protein
feature: ACTIVE 113
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

Protein kinase cAMP-dependent type II regulatory subunit alpha
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot E2RRD1 46
organism: Canis lupus familiaris

Protein kinase cAMP-dependent type I regulatory subunit alpha
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot F6R7N8 51
organism: Monodelphis domestica

Proteasome
type: Protein
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

uniprot Q28FL5 191
type: UnificationXref
id: Q28FL5
db: uniprot

Costal2 s43 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Costal2
stoichiometric coefficient: 1.0

Casein kinase I isoform epsilon
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot F6R2T7 15
organism: Macaca mulatta

DISSOCIATION
type: RelationshipTypeVocabulary

PaTChed family
type: ProteinReference
xref: uniprot Q09540 131
organism: Caenorhabditis elegans

uniprot A0A2R8RWN9 89
type: UnificationXref
id: A0A2R8RWN9
db: uniprot

uniprot F6PGQ1 168
type: UnificationXref
id: F6PGQ1
db: uniprot

uniprot Q8BK63 36
type: UnificationXref
id: Q8BK63
db: uniprot

PTHR13082:SF0
type: RelationshipXref
id: PTHR13082:SF0
db: PANTHER Family
relationship type: By Homology

uniprot Q8QG94 200
type: UnificationXref
id: Q8QG94
db: uniprot

uniprot Q8N752 40
type: UnificationXref
id: Q8N752
db: uniprot

uniprot E2RRA1 44
type: UnificationXref
id: E2RRA1
db: uniprot

GLI family zinc finger 1
type: ProteinReference
xref: uniprot A0A2I3SME4 137
organism: Pan troglodytes

Smoothened s11 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Smoothened
stoichiometric coefficient: 1.0

Costal2 s12 sa8 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR14604:SF4
type: RelationshipXref
id: PTHR14604:SF4
db: PANTHER Family
relationship type: By Homology

uniprot Q61115 134
type: UnificationXref
id: Q61115
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: uniprot Q01386 75
xref: PTHR11635:SF152
organism: Neurospora crassa

Costal2
type: Protein
entity reference: Costal2
feature: Costal2 s6 sa5 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa5 284
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

Complex (Su(fu)/Fused/ Cubitus interruptus/Costal2/ Smoothened)
type: Complex
component stoichiometry: Costal2 s43 sa23 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cubitus interruptus s42 sa22 STOICHIOMETRY ID COMPLEX
component stoichiometry: Fused s41 sa21 STOICHIOMETRY ID COMPLEX
component stoichiometry: Su fu s40 sa20 STOICHIOMETRY ID COMPLEX
component stoichiometry: Smoothened s44 sa24 STOICHIOMETRY ID COMPLEX
component: Fused
component: Su(fu)
component: Costal2
component: Cubitus interruptus
component: Smoothened
feature: COMPLEX BINDING FEATURE s88 a123 247
feature: COMPLEX BINDING FEATURE s88 a123 249
feature: COMPLEX BINDING FEATURE s88 a123 243
feature: COMPLEX BINDING FEATURE s88 a123 241
feature: COMPLEX BINDING FEATURE s88 a123 245
cellular location: membrane raft

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: uniprot P12849 66
xref: PTHR11635:SF126
organism: Mus musculus

uniprot F6YGY2 128
type: UnificationXref
id: F6YGY2
db: uniprot

Su(fu)
type: Protein
entity reference: Su(fu)
feature: COMPLEX PARTICIPANT BINDING FEATURE s54 sa44 238
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Glycogen synthase kinase 3
type: ProteinReference
xref: uniprot Q9YH60 175
xref: PTHR24057:SF8
organism: Danio rerio

GO GO:0005634 3
type: UnificationXref
id: GO:0005634
db: GO

STATE_TRANSITION
type: RelationshipTypeVocabulary

Suppressor of fused homolog
type: ProteinReference
xref: PTHR10928:SF2
xref: uniprot Q9VG38 202
organism: Drosophila melanogaster

TRANSPORT_LEFT__Complex__Cubitus_interruptus_repressor_Su_fu__-RIGHT__Complex__Cubitus_interruptus_repressor_Su_fu__-_r42
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 323
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 322
left: Complex (Cubitus interruptus repressor/Su(fu))
interaction type: TRANSPORT
right: Complex (Cubitus interruptus repressor/Su(fu))

F-box and WD repeat domain containing 11
type: ProteinReference
xref: uniprot A0A2I3SMC0 88
xref: PTHR44156:SF9
organism: Pan troglodytes

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot F6WM87 52
organism: Macaca mulatta

uniprot H2REV2 22
type: UnificationXref
id: H2REV2
db: uniprot

PTHR24115:SF795
type: RelationshipXref
id: PTHR24115:SF795
db: PANTHER Family
relationship type: By Homology

Suppressor of fused homolog
type: ProteinReference
xref: PTHR10928:SF2
xref: uniprot A0A2I3SA11 195
organism: Pan troglodytes

Complex (Costal2/Fused/ Su(fu)/Cubitus interruptus/ Smoothened/MIcrotubule)
type: Complex
component stoichiometry: Smoothened s37 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: Fused s34 sa15 STOICHIOMETRY ID COMPLEX
component stoichiometry: Su fu s35 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cubitus interruptus s36 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: Costal2 s33 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: MIcrotubule s38 sa19 STOICHIOMETRY ID COMPLEX
component: MIcrotubule
component: Cubitus interruptus
component: Su(fu)
component: Smoothened
component: Fused
component: Costal2
feature: COMPLEX BINDING FEATURE s84 a115 209
feature: ACTIVE 113
feature: COMPLEX BINDING FEATURE s84 a115 213
feature: COMPLEX BINDING FEATURE s84 a115 217
feature: COMPLEX BINDING FEATURE s84 a115 219
feature: COMPLEX BINDING FEATURE s84 a115 215
feature: COMPLEX BINDING FEATURE s84 a115 211
cellular location: membrane raft

F-box/WD repeat-containing protein 11
type: ProteinReference
xref: PTHR44129:SF4
xref: uniprot Q5SRY7 101
organism: Mus musculus

uniprot H2QVC7 107
type: UnificationXref
id: H2QVC7
db: uniprot

Smoothened homolog
type: ProteinReference
xref: uniprot P97698 110
xref: PTHR11309:SF35
organism: Rattus norvegicus

uniprot Q80TP3 184
type: UnificationXref
id: Q80TP3
db: uniprot

TRANSPORT_LEFT__Complex__Costal2_Fused__Smoothened_-RIGHT__Complex__Costal2_Fused__Smoothened_-_r14
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 318
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 319
left: Complex (Costal2/Fused/ Smoothened)
interaction type: TRANSPORT
right: Complex (Costal2/Fused/ Smoothened)

Prkar1a protein
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot Q5I0F6 78
organism: Danio rerio

uniprot P12368 64
type: UnificationXref
id: P12368
db: uniprot

CREB binding protein
type: ProteinReference
xref: uniprot F1PY87 155
xref: PTHR13808:SF34
organism: Canis lupus familiaris

uniprot P31324 73
type: UnificationXref
id: P31324
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HD33 114
organism: Macaca mulatta

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot F6Q503 48
xref: PTHR11635:SF156
organism: Macaca mulatta

Cubitus interruptus
type: Protein
entity reference: Cubitus interruptus
feature: Cubitus interruptus s70 a223 rs1
feature: Cubitus interruptus s70 a223 rs4
feature: ACTIVE 113
feature: Cubitus interruptus s70 a223 rs3
feature: Cubitus interruptus s70 a223 rs2
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 165

uniprot P18266 171
type: UnificationXref
id: P18266
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 70

Slimb
type: Protein
entity reference: Slimb
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa35 234
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

Costal2 s33 sa14 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Su fu s28 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Su(fu)
stoichiometric coefficient: 1.0

uniprot Q9YH60 175
type: UnificationXref
id: Q9YH60
db: uniprot

Costal2
type: Protein
entity reference: Costal2
feature: Costal2 s43 sa23 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s43 sa23 248
cellular location: membrane raft
comment: SPECIES_TYPE=PROTEIN

uniprot F7FVG8 99
type: UnificationXref
id: F7FVG8
db: uniprot

uniprot F6R7D0 185
type: UnificationXref
id: F6R7D0
db: uniprot

Patched s153 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Patched
stoichiometric coefficient: 1.0

uniprot A0A2R8QMX9 138
type: UnificationXref
id: A0A2R8QMX9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Su_fu__Slimb__Cubitus_interruptus_-RIGHT__Complex__Cubitus_interruptus_repressor_Su_fu__-_r41
controller: Proteasome

Patched
type: Protein
entity reference: Patched
feature: COMPLEX PARTICIPANT BINDING FEATURE s153 sa1 222
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

uniprot F7HD33 114
type: UnificationXref
id: F7HD33
db: uniprot

RCG23529, isoform CRA_a
type: ProteinReference
xref: uniprot G3V7F6 187
xref: PTHR13082:SF0
organism: Rattus norvegicus

Patched s4 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Patched
stoichiometric coefficient: 1.0

TRANSPORT
type: RelationshipTypeVocabulary

Predicted protein
type: ProteinReference
xref: uniprot A7RPJ6 11
xref: PTHR11909:SF20
organism: Nematostella vectensis

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: PTHR11635:SF162
xref: uniprot W4YRI6 83
organism: Strongylocentrotus purpuratus

uniprot F6ZM01 179
type: UnificationXref
id: F6ZM01
db: uniprot

PARTICIPANT STOICHIOMETRY re25 328
type: Stoichiometry
physical entity: Debra
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re25 329
type: Stoichiometry
physical entity: Debra
stoichiometric coefficient: 1.0

membrane raft
type: CellularLocationVocabulary
xref: GO GO:0045121 4

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: uniprot E2RB53 167
xref: PTHR24057:SF8
organism: Canis lupus familiaris

Casein kinase I
type: Protein
entity reference: Casein kinase I
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Cubitus_interruptus-RIGHT__a202_degraded-_r44
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 321
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 320
left: Cubitus interruptus
interaction type: STATE_TRANSITION
right: a202_degraded

GLI family zinc finger 1
type: ProteinReference
xref: uniprot E2QZT1 140
organism: Canis lupus familiaris

ncbitaxon 367110 76
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot E2RRD1 46
type: UnificationXref
id: E2RRD1
db: uniprot

PKA
type: Protein
entity reference: PKA
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BE57 105
xref: PTHR11309:SF35
organism: Bos taurus

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 119

Cubitus interruptus
type: Protein
entity reference: Cubitus interruptus
feature: Cubitus interruptus s32 sa38 rs4
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa38 270
feature: Cubitus interruptus s32 sa38 rs3
feature: Cubitus interruptus s32 sa38 rs1
feature: Cubitus interruptus s32 sa38 rs2
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

uniprot F6XVN5 94
type: UnificationXref
id: F6XVN5
db: uniprot

Slimb
type: ProteinReference
xref: P00683
comment: ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Slimb
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Slimb Synonym: Supernumerary limbs,beta TRCP,beta transducin Accession: P00683
member entity reference: F-box/WD repeat-containing protein 1A
member entity reference: F-box/WD repeat-containing protein 11
member entity reference: Beta-transducin repeat containing E3 ubiquitin protein ligase
member entity reference: F-box and WD repeat domain-containing 11b
member entity reference: F-box and WD repeat domain-containing 11
member entity reference: F-box and WD repeat domain containing 11
member entity reference: AGAP001944-PA
member entity reference: Beta-transducin repeat-containing E3 ubiquitin protein ligase
member entity reference: Uncharacterized protein

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 8

Casein kinase 1 epsilon
type: ProteinReference
xref: uniprot A0A2I3RHK0 6
xref: PTHR11909:SF18
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r38 300
type: Stoichiometry
physical entity: Complex (Su(fu)/Cubitus interruptus)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r38 301
type: Stoichiometry
physical entity: Slimb
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r38 302
type: Stoichiometry
physical entity: Complex (Cubitus interruptus/Su(fu)/ Slimb)
stoichiometric coefficient: 1.0

Glycogen synthase kinase-3 beta isoform 1
type: ProteinReference
xref: uniprot H9EPM1 170
xref: PTHR24057:SF8
organism: Macaca mulatta

uniprot P31323 72
type: UnificationXref
id: P31323
db: uniprot

STATE_TRANSITION_LEFT__Complex__Patched_Hedgehog_-RIGHT__a31_degraded-_r10
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 324
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 325
left: Complex (Patched/Hedgehog)
interaction type: STATE_TRANSITION
right: a31_degraded

Hedgehog target gene
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

PARTICIPANT STOICHIOMETRY r40 330
type: Stoichiometry
physical entity: Complex (Cubitus interruptus/Su(fu)/ Slimb)
stoichiometric coefficient: 1.0

uniprot A0A2I3SXI2 162
type: UnificationXref
id: A0A2I3SXI2
db: uniprot

PARTICIPANT STOICHIOMETRY r40 331
type: Stoichiometry
physical entity: Ubiquitin
stoichiometric coefficient: 1.0

ADP
type: SmallMolecule
cellular location: Receiving cell c1
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r40 332
type: Stoichiometry
physical entity: Complex (Su(fu)/Slimb/ Cubitus interruptus)
stoichiometric coefficient: 1.0

Costal2
type: Protein
entity reference: Costal2
feature: Costal2 s12 sa8 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa8 260
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

Smoothened s37 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Smoothened
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot P00514 59
xref: PTHR11635:SF129
organism: Bos taurus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P00515 60
organism: Bos taurus

uniprot Q5XGI6 35
type: UnificationXref
id: Q5XGI6
db: uniprot

Complex (CBP/Cubitus interruptus)
type: Complex
component stoichiometry: Cubitus interruptus s47 sa47 STOICHIOMETRY ID COMPLEX
component stoichiometry: CBP s45 sa46 STOICHIOMETRY ID COMPLEX
component: Cubitus interruptus
component: CBP
feature: COMPLEX BINDING FEATURE s143 a227 205
feature: COMPLEX BINDING FEATURE s143 a227 207
cellular location: nucleus

uniprot F7H8W1 106
type: UnificationXref
id: F7H8W1
db: uniprot

Slimb
type: Protein
entity reference: Slimb
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

uniprot Q9Z0P7 203
type: UnificationXref
id: Q9Z0P7
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 18

PARTICIPANT STOICHIOMETRY r53 295
type: Stoichiometry
physical entity: Cubitus interruptus
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 296
type: Stoichiometry
physical entity: Cubitus interruptus
stoichiometric coefficient: 1.0

ncbitaxon 7739 119
type: UnificationXref
id: 7739
db: ncbitaxon

Ubiquitin protein ligase E3 component n-recognin 5
type: ProteinReference
xref: uniprot F6VZ48 178
organism: Monodelphis domestica

Ubiquitin ligase
type: Protein
entity reference: Ubiquitin ligase
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

CREB-binding protein
type: ProteinReference
xref: uniprot Q92793 161
xref: PTHR13808:SF34
organism: Homo sapiens

Complex (Cubitus interruptus/Su(fu)/ Slimb)
type: Complex
component stoichiometry: Su fu s28 sa34 STOICHIOMETRY ID COMPLEX
component stoichiometry: Slimb s29 sa35 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cubitus interruptus s25 sa33 STOICHIOMETRY ID COMPLEX
component: Slimb
component: Su(fu)
component: Cubitus interruptus
feature: COMPLEX BINDING FEATURE s113 a175 229
feature: COMPLEX BINDING FEATURE s113 a175 231
feature: COMPLEX BINDING FEATURE s113 a175 233
cellular location: Receiving cell c1

uniprot P12367 63
type: UnificationXref
id: P12367
db: uniprot

Complex (Patched/Hedgehog)
type: Complex
component stoichiometry: Hedgehog s5 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: Patched s4 sa3 STOICHIOMETRY ID COMPLEX
component: Patched
component: Hedgehog
feature: COMPLEX BINDING FEATURE s22 a31 227
feature: COMPLEX BINDING FEATURE s22 a31 225
cellular location: endosome

Protein patched homolog 1
type: ProteinReference
xref: PTHR46022:SF5
xref: uniprot Q13635 133
organism: Homo sapiens

Casein kinase 1, epsilon
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot Q99PS2 41
organism: Rattus norvegicus

E3 ubiquitin-protein ligase UBR5
type: ProteinReference
xref: uniprot O95071 182
organism: Homo sapiens

TRANSCRIPTION
type: InteractionVocabulary

Transcriptional activator GLI3
type: ProteinReference
xref: PTHR45718:SF5
xref: uniprot P10071 149
organism: Homo sapiens

ncbitaxon 6669 14
type: UnificationXref
id: 6669
db: ncbitaxon

Casein kinase I isoform alpha isoform 1
type: ProteinReference
xref: uniprot H9ENA3 23
xref: PTHR11909:SF84
organism: Macaca mulatta

uniprot Q5I0F6 78
type: UnificationXref
id: Q5I0F6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1N0L2 176
organism: Bos taurus

AGAP004940-PA
type: ProteinReference
xref: uniprot Q7PPI8 80
xref: PTHR11635:SF162
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
xref: PTHR44156:SF2
xref: uniprot F1MVN1 93
organism: Bos taurus

uniprot A0A2I3RHK0 6
type: UnificationXref
id: A0A2I3RHK0
db: uniprot

uniprot P48729 27
type: UnificationXref
id: P48729
db: uniprot

Cubitus interruptus s23 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cubitus interruptus
stoichiometric coefficient: 1.0

Suppressor of fused homolog
type: ProteinReference
xref: uniprot Q8QG94 200
organism: Gallus gallus

Kinesin-like protein costa
type: ProteinReference
xref: PTHR24115:SF795
xref: uniprot O16844 204
organism: Drosophila melanogaster

uniprot Q9UKB1 103
type: UnificationXref
id: Q9UKB1
db: uniprot

uniprot Q6UY90 135
type: UnificationXref
id: Q6UY90
db: uniprot

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: uniprot Q9WV60 174
xref: PTHR24057:SF8
organism: Mus musculus

F-box and WD repeat domain-containing 11
type: ProteinReference
xref: uniprot A0A0G2JVE0 85
xref: PTHR44129:SF4
organism: Rattus norvegicus

Hedgehog
type: Protein
entity reference: Hedgehog
comment: SPECIES_TYPE=PROTEIN

Su(fu)
type: Protein
entity reference: Su(fu)
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa25 272
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 189

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot E2RRA1 44
xref: PTHR11635:SF156
organism: Canis lupus familiaris

Fused s14 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fused
stoichiometric coefficient: 1.0

UBR5 isoform 4
type: ProteinReference
xref: uniprot H2QWJ0 181
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r7 317
type: Stoichiometry
physical entity: Complex (Patched/Hedgehog)
stoichiometric coefficient: 1.0

Zinc finger protein GLI1
type: ProteinReference
xref: uniprot P47806 151
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r7 316
type: Stoichiometry
physical entity: Hedgehog
stoichiometric coefficient: 1.0

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot P18266 171
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r7 315
type: Stoichiometry
physical entity: Patched
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Complex__Su_fu__Cubitus_interruptus_-_ATP-RIGHT__Complex__Su_fu__Cubitus_interruptus_-_ADP-_r30
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 304
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 305
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 306
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 303
left: ATP
left: Complex (Su(fu)/Cubitus interruptus)
interaction type: STATE_TRANSITION
right: ADP
right: Complex (Su(fu)/Cubitus interruptus)

Cubitus interruptus
type: Protein
entity reference: Cubitus interruptus
feature: Cubitus interruptus s70 a46 rs4
feature: Cubitus interruptus s70 a46 rs1
feature: Cubitus interruptus s70 a46 rs2
feature: Cubitus interruptus s70 a46 rs3
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

F-box and WD repeat domain containing 11
type: ProteinReference
xref: uniprot F6YUQ2 95
xref: PTHR44129:SF4
organism: Ornithorhynchus anatinus

Fused
type: ProteinReference
xref: P00686
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Fused
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Uncharacterized protein
member entity reference: STK36 isoform 2
member entity reference: Serine/threonine-protein kinase fused
member entity reference: Serine/threonine-protein kinase 36

Danio rerio
type: BioSource
xref: ncbitaxon 7955 39

uniprot Q92793 161
type: UnificationXref
id: Q92793
db: uniprot

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P13861 67
organism: Homo sapiens

uniprot G3V6X8 147
type: UnificationXref
id: G3V6X8
db: uniprot

Smoothened homolog
type: ProteinReference
xref: uniprot Q99835 112
xref: PTHR11309:SF35
organism: Homo sapiens

GLI family zinc finger 3
type: ProteinReference
xref: uniprot F6XFR9 144
xref: PTHR45718:SF5
organism: Xenopus tropicalis

GLI family zinc finger 1
type: ProteinReference
xref: uniprot F1QAC4 142
organism: Danio rerio

Cubitus interruptus s36 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cubitus interruptus
stoichiometric coefficient: 1.0

ncbitaxon 227321 58
type: UnificationXref
id: 227321
db: ncbitaxon

Histone deacetylase complex subunit SAP18
type: ProteinReference
xref: PTHR13082:SF0
xref: uniprot Q6PC41 192
organism: Danio rerio

PTHR10928:SF2
type: RelationshipXref
id: PTHR10928:SF2
db: PANTHER Family
relationship type: By Homology

Smoothened s13 sa9 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Su fu s40 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Su(fu)
stoichiometric coefficient: 1.0

IDA
type: EvidenceCodeVocabulary

Cubitus interruptus
type: Protein
entity reference: Cubitus interruptus
feature: Cubitus interruptus s130 a202 rs3
feature: Cubitus interruptus s130 a202 rs1
feature: Cubitus interruptus s130 a202 rs4
feature: Cubitus interruptus s130 a202 rs2
cellular location: lysosome
comment: SPECIES_TYPE=PROTEIN

Beta-transducin repeat-containing E3 ubiquitin protein ligase
type: ProteinReference
xref: uniprot F6XVN5 94
xref: PTHR19849:SF1
organism: Xenopus tropicalis

Cubitus interruptus s47 sa47 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=1.65

Hedgehog protein
type: ProteinReference
xref: uniprot J9NYK0 121
xref: PTHR11889:SF36
organism: Canis lupus familiaris

Cubitus interruptus s42 sa22 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.66

uniprot W4Y925 125
type: UnificationXref
id: W4Y925
db: uniprot

uniprot Q90693 136
type: UnificationXref
id: Q90693
db: uniprot

F-box and WD repeat domain containing 11
type: ProteinReference
xref: uniprot A0A3Q1M118 90
xref: PTHR44129:SF4
organism: Bos taurus

CREB-binding protein isoform a
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot F6RRA8 156
organism: Macaca mulatta

PTHR19855:SF12
type: RelationshipXref
id: PTHR19855:SF12
db: PANTHER Family
relationship type: By Homology

uniprot H9ENA3 23
type: UnificationXref
id: H9ENA3
db: uniprot

uniprot A0A2I3SA11 195
type: UnificationXref
id: A0A2I3SA11
db: uniprot

uniprot Q9VEX9 193
type: UnificationXref
id: Q9VEX9
db: uniprot

PTHR44129:SF4
type: RelationshipXref
id: PTHR44129:SF4
db: PANTHER Family
relationship type: By Homology

ncbitaxon 7668 84
type: UnificationXref
id: 7668
db: ncbitaxon

Costal2 s43 sa23 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Cubitus interruptus s42 sa22 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Cubitus interruptus s47 sa47 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.66

uniprot A0A2I3RLP7 10
type: UnificationXref
id: A0A2I3RLP7
db: uniprot

uniprot A0A0G2JVE0 85
type: UnificationXref
id: A0A0G2JVE0
db: uniprot

AGAP001944-PA
type: ProteinReference
xref: uniprot Q7PYH7 102
xref: PTHR19855:SF12
organism: Anopheles gambiae

uniprot Q7PYH7 102
type: UnificationXref
id: Q7PYH7
db: uniprot

Cubitus interruptus s163 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cubitus interruptus
stoichiometric coefficient: 1.0

uniprot A0A1D5PCI4 43
type: UnificationXref
id: A0A1D5PCI4
db: uniprot

Cubitus interruptus s42 sa22 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 34

ncbitaxon 9598 7
type: UnificationXref
id: 9598
db: ncbitaxon

Cubitus interruptus s47 sa47 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Casein kinase 1, alpha 1
type: ProteinReference
xref: uniprot Q8JHE0 38
xref: PTHR11909:SF20
organism: Danio rerio

uniprot Q6PC41 192
type: UnificationXref
id: Q6PC41
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 14

INHIBITION
type: RelationshipTypeVocabulary

uniprot P12849 66
type: UnificationXref
id: P12849
db: uniprot

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot Q9DBC7 82
organism: Mus musculus

GSK3
type: Protein
entity reference: GSK3
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

uniprot F6XFR9 144
type: UnificationXref
id: F6XFR9
db: uniprot

uniprot Q5SRY7 101
type: UnificationXref
id: Q5SRY7
db: uniprot

Cubitus interruptus s42 sa22 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=1.65

Suppressor of fused homolog
type: ProteinReference
xref: uniprot Q7PYI0 199
organism: Anopheles gambiae

Cubitus interruptus s47 sa47 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

Serine/threonine-protein kinase 36
type: ProteinReference
xref: uniprot Q9NRP7 117
organism: Homo sapiens

STATE_TRANSITION_LEFT__Cubitus_interruptus-RIGHT__Cubitus_interruptus-_r53
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 296
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 295
left: Cubitus interruptus
interaction type: STATE_TRANSITION
right: Cubitus interruptus

Su fu s20 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Su(fu)
stoichiometric coefficient: 1.0

Debra
type: Protein
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

Cubitus interruptus
type: Protein
entity reference: Cubitus interruptus
feature: Cubitus interruptus s36 sa17 rs1
feature: Cubitus interruptus s36 sa17 rs4
feature: Cubitus interruptus s36 sa17 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s36 sa17 216
feature: Cubitus interruptus s36 sa17 rs3
cellular location: membrane raft
comment: SPECIES_TYPE=PROTEIN

Costal2 s15 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Costal2
stoichiometric coefficient: 1.0

Smoothened s44 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Smoothened
stoichiometric coefficient: 1.0

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__Hedgehog_target_gene-RIGHT__Hedgehog_target_gene-_re24
control type: INHIBITION
controller: Complex (Sap18/Su(fu)/ Cubitus interruptus repressor)

PKA
type: ProteinReference
xref: P00682
standard name: Protein kinase A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: PKA Synonym: Protein kinase A,cAMP-dependent Protein Kinase A Accession: P00682
comment: ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.PKA
member entity reference: cAMP-dependent protein kinase regulatory subunit
member entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit
member entity reference: Prkar1a protein
member entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit
member entity reference: PRKAR2A isoform 1
member entity reference: PRKAR1A isoform 12
member entity reference: Protein kinase cAMP-dependent type I regulatory subunit alpha
member entity reference: cAMP-dependent protein kinase type II regulatory subunit
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit beta
member entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit
member entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit
member entity reference: Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
member entity reference: Protein kinase, cAMP-dependent, regulatory, type I, beta
member entity reference: cAMP-dependent protein kinase type I regulatory subunit
member entity reference: AGAP004940-PA
member entity reference: Uncharacterized protein
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit alpha

Cubitus interruptus
type: Protein
entity reference: Cubitus interruptus
feature: COMPLEX PARTICIPANT BINDING FEATURE s163 sa32 282
feature: Cubitus interruptus s163 sa32 rs1
feature: Cubitus interruptus s163 sa32 rs3
feature: Cubitus interruptus s163 sa32 rs2
feature: Cubitus interruptus s163 sa32 rs4
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

Hedgehog
type: Protein
entity reference: Hedgehog
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa4 228
cellular location: endosome
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9258 96
type: UnificationXref
id: 9258
db: ncbitaxon

a202_degraded
type: PhysicalEntity
cellular location: Receiving cell c1
comment: SPECIES_TYPE=DEGRADED

uniprot Q01386 75
type: UnificationXref
id: Q01386
db: uniprot

uniprot Q13635 133
type: UnificationXref
id: Q13635
db: uniprot

PARTICIPANT STOICHIOMETRY r30 303
type: Stoichiometry
physical entity: Complex (Su(fu)/Cubitus interruptus)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r30 304
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r30 305
type: Stoichiometry
physical entity: Complex (Su(fu)/Cubitus interruptus)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r30 306
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Su(fu)
type: Protein
entity reference: Su(fu)
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa34 232
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

uniprot P91682 109
type: UnificationXref
id: P91682
db: uniprot

uniprot P97633 33
type: UnificationXref
id: P97633
db: uniprot

Costal2 s6 sa5 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Patched 1
type: ProteinReference
xref: PTHR46022:SF5
xref: uniprot F7DZP4 129
organism: Xenopus tropicalis

uniprot F1LMH8 92
type: UnificationXref
id: F1LMH8
db: uniprot

Patched
type: Protein
entity reference: Patched
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa3 226
cellular location: endosome
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Su_fu__Cubitus_interruptus_-_ATP-RIGHT__Complex__Su_fu__Cubitus_interruptus_-_ADP-_r30
controller: Casein kinase I

uniprot E2RB53 167
type: UnificationXref
id: E2RB53
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7C1G3 21
xref: PTHR11909:SF20
organism: Monodelphis domestica

Su fu s50 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Su(fu)
stoichiometric coefficient: 1.0

uniprot Q9UMX1 201
type: UnificationXref
id: Q9UMX1
db: uniprot

uniprot Q9Y297 104
type: UnificationXref
id: Q9Y297
db: uniprot

CBP
type: ProteinReference
xref: P00691
standard name: CREB binding protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: CBP Synonym: CREB binding protein,p300 Accession: P00691
comment: ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.CBP
member entity reference: Uncharacterized protein
member entity reference: CREB-binding protein
member entity reference: CREB binding protein
member entity reference: CREB-binding protein isoform a

Histone deacetylase complex subunit SAP18
type: ProteinReference
xref: uniprot O64644 188
organism: Arabidopsis thaliana

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 58

cAMP-dependent protein kinase type I regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P16905 68
organism: Drosophila melanogaster

Ubiquitin ligase
type: ProteinReference
xref: P00693
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Ubiquitin_space_ligase
comment: ENTITY_REFERENCE_NOTES=Long Name: Ubiquitin ligase Synonym: Synonym not specified Accession: P00693
member entity reference: Ubiquitin protein ligase E3 component n-recognin 5
member entity reference: Uncharacterized protein
member entity reference: E3 ubiquitin-protein ligase UBR5
member entity reference: E3 ubiquitin-protein ligase hyd
member entity reference: UBR5 isoform 4

Patched
type: ProteinReference
xref: P00689
comment: ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.RECEPTOR.Patched
comment: ENTITY_REFERENCE_NOTES=Long Name: Patched Synonym: Ptc,Ptc1 Accession: P00689
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Protein patched homolog 1
member entity reference: PaTChed family
member entity reference: Uncharacterized protein
member entity reference: Patched
member entity reference: Patched 1
member entity reference: Protein patched

HETERODIMER_ASSOCIATION_LEFT__Complex__Cubitus_interruptus_repressor_Su_fu__-_Sap18-RIGHT__Complex__Sap18_Su_fu___Cubitus_interruptus_repressor_-_r51
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 299
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 297
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 298
left: Complex (Cubitus interruptus repressor/Su(fu))
left: Sap18
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Sap18/Su(fu)/ Cubitus interruptus repressor)

Costal2 s6 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Costal2
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase fused
type: ProteinReference
xref: uniprot P23647 116
organism: Drosophila melanogaster

Fused s41 sa21 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

ncbitaxon 9031 32
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot P13861 67
type: UnificationXref
id: P13861
db: uniprot

Cubitus interruptus s163 sa32 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Cubitus interruptus s70 a223 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot Q08C49 77
type: UnificationXref
id: Q08C49
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR46022:SF5
xref: uniprot F6YGY2 128
organism: Monodelphis domestica

Cubitus interruptus s25 sa33 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cubitus interruptus
stoichiometric coefficient: 1.0

ncbitaxon 10090 37
type: UnificationXref
id: 10090
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Complex__Su_fu__Cubitus_interruptus_-RIGHT__Cubitus_interruptus-_r56
controller: Debra

uniprot A6H727 139
type: UnificationXref
id: A6H727
db: uniprot

GLI family zinc finger 2a
type: ProteinReference
xref: uniprot A0A2R8QMX9 138
organism: Danio rerio

Cubitus interruptus s25 sa33 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

Cubitus interruptus s70 a46 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.66

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H8W1 106
xref: PTHR11309:SF35
organism: Macaca mulatta

Cubitus interruptus s19 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cubitus interruptus
stoichiometric coefficient: 1.0

uniprot Q9VG38 202
type: UnificationXref
id: Q9VG38
db: uniprot

TRANSPORT_LEFT__Complex__Patched_Hedgehog_-RIGHT__Complex__Patched_Hedgehog_-_r8
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 310
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 309
left: Complex (Patched/Hedgehog)
interaction type: TRANSPORT
right: Complex (Patched/Hedgehog)

Cubitus interruptus s23 sa30 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.66

uniprot O95071 182
type: UnificationXref
id: O95071
db: uniprot

Cubitus interruptus s70 a223 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.66

Cubitus interruptus s42 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cubitus interruptus
stoichiometric coefficient: 1.0

Fused s34 sa15 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Cubitus interruptus s70 a46 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Suppressor of fused homolog
type: ProteinReference
xref: PTHR10928:SF2
xref: uniprot E2RAI7 196
organism: Canis lupus familiaris

uniprot Q3ULA2 100
type: UnificationXref
id: Q3ULA2
db: uniprot

lysosome
type: CellularLocationVocabulary
xref: GO GO:0005764 2

Cubitus interruptus s25 sa33 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=1.65

Cubitus interruptus s163 sa32 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.66

Hedgehog s3 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Hedgehog
stoichiometric coefficient: 1.0

endosome
type: CellularLocationVocabulary
xref: GO GO:0005768 5

ncbitaxon 13616 18
type: UnificationXref
id: 13616
db: ncbitaxon

Cubitus interruptus s163 sa32 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=1.65

uniprot Q9NRP7 117
type: UnificationXref
id: Q9NRP7
db: uniprot

uniprot P31321 71
type: UnificationXref
id: P31321
db: uniprot

MIcrotubule s38 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MIcrotubule
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Su_fu__Cubitus_interruptus_-_ATP-RIGHT__ADP-_Complex__Su_fu__Cubitus_interruptus_-_r29
controller: PKA

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 25

uniprot W4YRI6 83
type: UnificationXref
id: W4YRI6
db: uniprot

GO GO:0005764 2
type: UnificationXref
id: GO:0005764
db: GO

uniprot H2R3M7 54
type: UnificationXref
id: H2R3M7
db: uniprot

Cubitus interruptus s23 sa30 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

PTHR11309:SF35
type: RelationshipXref
id: PTHR11309:SF35
db: PANTHER Family
relationship type: By Homology

Histone deacetylase complex subunit SAP18
type: ProteinReference
xref: uniprot Q9VEX9 193
organism: Drosophila melanogaster

uniprot P56726 108
type: UnificationXref
id: P56726
db: uniprot

Cubitus interruptus s25 sa33 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.66

Suppressor of fused homolog
type: ProteinReference
xref: PTHR10928:SF2
xref: uniprot A0A1D5RFU7 194
organism: Macaca mulatta

Cubitus interruptus s163 sa32 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

Receiving cell c1
type: CellularLocationVocabulary
comment: Receiving cell

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: uniprot P49841 172
xref: PTHR24057:SF8
organism: Homo sapiens

KNOWN_TRANSITION_OMITTED_LEFT__Complex__Costal2_Fused__Su_fu__Cubitus_interruptus__Smoothened_MIcrotubule_-RIGHT__Complex__Su_fu__Cubitus_interruptus_-_r48
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 308
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 307
left: Complex (Costal2/Fused/ Su(fu)/Cubitus interruptus/ Smoothened/MIcrotubule)
interaction type: KNOWN_TRANSITION_OMITTED
right: Complex (Su(fu)/Cubitus interruptus)

uniprot A0A1D5P3W6 87
type: UnificationXref
id: A0A1D5P3W6
db: uniprot

uniprot P12369 65
type: UnificationXref
id: P12369
db: uniprot

F-box/WD repeat-containing protein 11
type: ProteinReference
xref: uniprot Q9UKB1 103
xref: PTHR44129:SF4
organism: Homo sapiens

TRANSCRIPTION_LEFT__Hedgehog_target_gene-RIGHT__Hedgehog_target_gene-_re24
type: TemplateReaction
product: Hedgehog target gene
xref: TRANSCRIPTION
participant: Hedgehog target gene
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Casein kinase 1 alpha 1
type: ProteinReference
xref: PTHR11909:SF84
xref: uniprot A0A2I3RLP7 10
organism: Pan troglodytes

Cubitus interruptus s23 sa30 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2TVV5 163
xref: PTHR24057:SF8
organism: Gallus gallus

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: uniprot F7ACT4 169
xref: PTHR24057:SF8
organism: Xenopus tropicalis

MIcrotubule
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa19 220
cellular location: membrane raft
comment: SPECIES_TYPE=PROTEIN

uniprot H2RER5 55
type: UnificationXref
id: H2RER5
db: uniprot

Cubitus interruptus s25 sa33 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

DISSOCIATION_LEFT__Complex__Costal2_Fused__Su_fu__Cubitus_interruptus__Smoothened_MIcrotubule_-RIGHT__Microtubule-_Complex__Su_fu__Fused__Cubitus_interruptus_Costal2__Smoothened_-_r23
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 349
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 348
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 347
left: Complex (Costal2/Fused/ Su(fu)/Cubitus interruptus/ Smoothened/MIcrotubule)
interaction type: DISSOCIATION
right: Complex (Su(fu)/Fused/ Cubitus interruptus/Costal2/ Smoothened)
right: Microtubule

PTHR44156:SF2
type: RelationshipXref
id: PTHR44156:SF2
db: PANTHER Family
relationship type: By Homology

uniprot P45481 159
type: UnificationXref
id: P45481
db: uniprot

uniprot P81900 74
type: UnificationXref
id: P81900
db: uniprot

PTHR19854:SF16
type: RelationshipXref
id: PTHR19854:SF16
db: PANTHER Family
relationship type: By Homology

uniprot F1QEC8 47
type: UnificationXref
id: F1QEC8
db: uniprot

uniprot F1N0L2 176
type: UnificationXref
id: F1N0L2
db: uniprot

Costal2 s33 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Costal2
stoichiometric coefficient: 1.0

Casein kinase I isoform alpha-like
type: ProteinReference
xref: uniprot Q8N752 40
xref: PTHR11909:SF139
organism: Homo sapiens

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot P10644 61
organism: Homo sapiens

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 20

PTHR44156:SF9
type: RelationshipXref
id: PTHR44156:SF9
db: PANTHER Family
relationship type: By Homology

Suppressor of fused homolog
type: ProteinReference
xref: uniprot Q9Z0P7 203
xref: PTHR10928:SF2
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r29 333
type: Stoichiometry
physical entity: Complex (Su(fu)/Cubitus interruptus)
stoichiometric coefficient: 1.0

uniprot J9NYK0 121
type: UnificationXref
id: J9NYK0
db: uniprot

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__Costal2_Fused__Su_fu__Cubitus_interruptus__Smoothened_MIcrotubule_-RIGHT__Microtubule-_Complex__Su_fu__Fused__Cubitus_interruptus_Costal2__Smoothened_-_r23
controller: Complex (Patched/Hedgehog)

Su fu s54 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Su(fu)
stoichiometric coefficient: 1.0

GLI family zinc finger 3
type: ProteinReference
xref: PTHR45718:SF5
xref: uniprot F1QSH8 143
organism: Danio rerio

Su fu s30 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Su(fu)
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Complex__Cubitus_interruptus_Su_fu___Slimb_-_Ubiquitin-RIGHT__Complex__Su_fu__Slimb__Cubitus_interruptus_-_r40
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 332
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 331
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 330
left: Ubiquitin
left: Complex (Cubitus interruptus/Su(fu)/ Slimb)
interaction type: STATE_TRANSITION
right: Complex (Su(fu)/Slimb/ Cubitus interruptus)

Costal2
type: ProteinReference
xref: P00698
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Costal2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Kinesin-like protein costa

Ubiquitin
type: SmallMolecule
cellular location: Receiving cell c1
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r29 336
type: Stoichiometry
physical entity: Complex (Su(fu)/Cubitus interruptus)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r29 334
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot Q6JHU9 160
type: UnificationXref
id: Q6JHU9
db: uniprot

PARTICIPANT STOICHIOMETRY r29 335
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot F7HP77 146
type: UnificationXref
id: F7HP77
db: uniprot

Smoothened homolog
type: ProteinReference
xref: uniprot P56726 108
xref: PTHR11309:SF35
organism: Mus musculus

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: uniprot P30625 69
xref: PTHR11635:SF152
organism: Caenorhabditis elegans

PTHR11889:SF31
type: RelationshipXref
id: PTHR11889:SF31
db: PANTHER Family
relationship type: By Homology

Cubitus interruptus repressor
type: Protein
entity reference: Cubitus interruptus repressor
feature: COMPLEX PARTICIPANT BINDING FEATURE s149 sa39 252
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

uniprot C3ZGW9 118
type: UnificationXref
id: C3ZGW9
db: uniprot

PTHR11889:SF36
type: RelationshipXref
id: PTHR11889:SF36
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FGS3 98
xref: PTHR44156:SF9
organism: Monodelphis domestica

uniprot F6R2T7 15
type: UnificationXref
id: F6R2T7
db: uniprot

uniprot P23647 116
type: UnificationXref
id: P23647
db: uniprot

uniprot F1QSH8 143
type: UnificationXref
id: F1QSH8
db: uniprot

uniprot F7CXR4 186
type: UnificationXref
id: F7CXR4
db: uniprot

ncbitaxon 6238 165
type: UnificationXref
id: 6238
db: ncbitaxon

CBP s45 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CBP
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot Q5ZM91 79
organism: Gallus gallus

Su(fu)
type: Protein
entity reference: Su(fu)
feature: COMPLEX PARTICIPANT BINDING FEATURE s50 sa40 254
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9544 16
type: UnificationXref
id: 9544
db: ncbitaxon

Protein kinase, cAMP-dependent, regulatory, type I, beta
type: ProteinReference
xref: PTHR11635:SF126
xref: uniprot Q08C49 77
organism: Danio rerio

PTHR24057:SF8
type: RelationshipXref
id: PTHR24057:SF8
db: PANTHER Family
relationship type: By Homology

Sonic hedgehog protein
type: ProteinReference
xref: PTHR11889:SF36
xref: uniprot Q15465 123
organism: Homo sapiens

Cubitus interruptus s19 sa26 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=1.65

uniprot Q5IS56 152
type: UnificationXref
id: Q5IS56
db: uniprot

uniprot P97698 110
type: UnificationXref
id: P97698
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 50

uniprot H2QWJ0 181
type: UnificationXref
id: H2QWJ0
db: uniprot

Beta-transducin repeat containing E3 ubiquitin protein ligase
type: ProteinReference
xref: uniprot E2RDC4 91
xref: PTHR44156:SF2
organism: Canis lupus familiaris

Fused
type: Protein
entity reference: Fused
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa10 264
feature: Fused s14 sa10 rs1
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FVG8 99
xref: PTHR44129:SF4
organism: Macaca mulatta

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 96

Slimb s31 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Slimb
stoichiometric coefficient: 1.0

Casein kinase I isoform epsilon
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot P49674 29
organism: Homo sapiens

Ubiquitin protein ligase E3 component n-recognin 5
type: ProteinReference
xref: uniprot F6ZM01 179
organism: Xenopus tropicalis

Patched
type: ProteinReference
xref: uniprot Q6UY90 135
xref: PTHR46022:SF5
organism: Rattus norvegicus

Patched 1
type: ProteinReference
xref: PTHR46022:SF5
xref: uniprot F1PNE0 127
organism: Canis lupus familiaris

Smoothened
type: ProteinReference
xref: P00685
comment: ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.RECEPTOR.Smoothened
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Smoothened homolog
member entity reference: Smoothened, frizzled class receptor
member entity reference: Protein smoothened
member entity reference: Uncharacterized protein

HETERODIMER_ASSOCIATION_LEFT__Patched-_Hedgehog-RIGHT__Complex__Patched_Hedgehog_-_r7
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 315
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 317
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 316
left: Hedgehog
left: Patched
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Patched/Hedgehog)

Cubitus interruptus s19 sa26 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

uniprot A0A2I3SME4 137
type: UnificationXref
id: A0A2I3SME4
db: uniprot

Histone deacetylase complex subunit SAP18
type: ProteinReference
xref: PTHR13082:SF0
xref: uniprot Q28FL5 191
organism: Xenopus tropicalis

uniprot P08151 148
type: UnificationXref
id: P08151
db: uniprot

Smoothened
type: Protein
entity reference: Smoothened
feature: Smoothened s37 sa18 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa18 218
cellular location: membrane raft
comment: SPECIES_TYPE=PROTEIN

Sap18
type: ProteinReference
xref: P00697
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Sap18 Synonym: Sin3-associated polypeptide 18 Accession: P00697
comment: ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Sap18
member entity reference: Histone deacetylase complex subunit SAP18
member entity reference: RCG23529, isoform CRA_a
member entity reference: Sin3A associated protein 18
member entity reference: Probable histone deacetylase complex subunit SAP18

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P31324 73
organism: Mus musculus

Transcriptional activator GLI3
type: ProteinReference
xref: PTHR45718:SF5
xref: uniprot Q5IS56 152
organism: Pan troglodytes

PTHR46022:SF1
type: RelationshipXref
id: PTHR46022:SF1
db: PANTHER Family
relationship type: By Homology

Smoothened
type: Protein
entity reference: Smoothened
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa13 294
feature: Smoothened s17 sa13 rs1
cellular location: membrane raft
comment: SPECIES_TYPE=PROTEIN

PTHR46022:SF5
type: RelationshipXref
id: PTHR46022:SF5
db: PANTHER Family
relationship type: By Homology

F-box/WD repeat-containing protein 1A
type: ProteinReference
xref: PTHR19854:SF16
xref: uniprot Q9Y297 104
organism: Homo sapiens

Cubitus interruptus repressor
type: ProteinReference
xref: P00687
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.TRUNCATED.Cubitus_br_interruptus_br_repressor
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Transcriptional activator GLI3
member entity reference: Uncharacterized protein
member entity reference: Transcriptional activator cubitus interruptus
member entity reference: GLI family zinc finger 3

Fused s16 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fused
stoichiometric coefficient: 1.0

Transcriptional activator GLI3
type: ProteinReference
xref: PTHR45718:SF5
xref: uniprot Q61602 153
organism: Mus musculus

Cubitus interruptus
type: Protein
entity reference: Cubitus interruptus
feature: Cubitus interruptus s23 sa30 rs1
feature: Cubitus interruptus s23 sa30 rs3
feature: Cubitus interruptus s23 sa30 rs4
feature: Cubitus interruptus s23 sa30 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa30 278
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r10 324
type: Stoichiometry
physical entity: Complex (Patched/Hedgehog)
stoichiometric coefficient: 1.0

ncbitaxon 10116 34
type: UnificationXref
id: 10116
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r10 325
type: Stoichiometry
physical entity: a31_degraded
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Complex__Su_fu__Cubitus_interruptus_-_Slimb-RIGHT__Complex__Cubitus_interruptus_Su_fu___Slimb_-_r38
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 301
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 302
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 300
left: Slimb
left: Complex (Su(fu)/Cubitus interruptus)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Cubitus interruptus/Su(fu)/ Slimb)

PTHR45718:SF4
type: RelationshipXref
id: PTHR45718:SF4
db: PANTHER Family
relationship type: By Homology

PTHR45718:SF5
type: RelationshipXref
id: PTHR45718:SF5
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QSK7 126
xref: PTHR46022:SF5
organism: Macaca mulatta

Cubitus interruptus
type: Protein
entity reference: Cubitus interruptus
feature: COMPLEX PARTICIPANT BINDING FEATURE s47 sa47 208
feature: ACTIVE 113
feature: Cubitus interruptus s47 sa47 rs3
feature: Cubitus interruptus s47 sa47 rs1
feature: Cubitus interruptus s47 sa47 rs2
feature: Cubitus interruptus s47 sa47 rs4
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot A7RPJ6 11
type: UnificationXref
id: A7RPJ6
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 45

uniprot Q9JMK2 42
type: UnificationXref
id: Q9JMK2
db: uniprot

Hedgehog
type: ProteinReference
xref: P00688
comment: ENTITY_REFERENCE_NOTES=Long Name: Hedgehog Synonym: Hh,Shh,Sonic hedgehog Accession: P00688
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Hedgehog
member entity reference: Hedgehog protein
member entity reference: Sonic hedgehog protein
member entity reference: Sonic hedgehog protein A
member entity reference: Protein hedgehog

uniprot O59922 57
type: UnificationXref
id: O59922
db: uniprot

CREB binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot F1MD32 154
organism: Bos taurus

Smoothened
type: Protein
entity reference: Smoothened
feature: Smoothened s13 sa9 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa9 262
feature: ACTIVE 113
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

uniprot F1MVN1 93
type: UnificationXref
id: F1MVN1
db: uniprot

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P31323 72
organism: Homo sapiens

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF126
xref: uniprot P31321 71
organism: Homo sapiens

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 32

uniprot F1Q8J2 177
type: UnificationXref
id: F1Q8J2
db: uniprot

Cubitus interruptus repressor s150 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cubitus interruptus repressor
stoichiometric coefficient: 1.0

uniprot P18502 130
type: UnificationXref
id: P18502
db: uniprot

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P12369 65
xref: PTHR11635:SF156
organism: Rattus norvegicus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: uniprot P12367 63
xref: PTHR11635:SF153
organism: Mus musculus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P12368 64
organism: Rattus norvegicus

uniprot Q5RH73 111
type: UnificationXref
id: Q5RH73
db: uniprot

uniprot O16844 204
type: UnificationXref
id: O16844
db: uniprot

Fused
type: Protein
entity reference: Fused
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa15 212
feature: Fused s34 sa15 rs1
cellular location: membrane raft
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r15 313
type: Stoichiometry
physical entity: Complex (Costal2/Smoothened/ Fused)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r15 314
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r15 311
type: Stoichiometry
physical entity: Complex (Costal2/Fused/ Smoothened)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r15 312
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Debra-RIGHT__Debra-_re25
control type: INHIBITION
controller: Complex (Patched/Hedgehog)

Protein hedgehog
type: ProteinReference
xref: PTHR11889:SF31
xref: uniprot Q02936 122
organism: Drosophila melanogaster

Su fu s18 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Su(fu)
stoichiometric coefficient: 1.0

Cubitus interruptus s23 sa30 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=1.65

Hedgehog
type: Protein
entity reference: Hedgehog
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa2 224
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

uniprot F6RRA8 156
type: UnificationXref
id: F6RRA8
db: uniprot

Complex (Cubitus interruptus repressor/Su(fu))
type: Complex
component stoichiometry: Cubitus interruptus repressor s149 sa39 STOICHIOMETRY ID COMPLEX
component stoichiometry: Su fu s50 sa40 STOICHIOMETRY ID COMPLEX
component: Su(fu)
component: Cubitus interruptus repressor
feature: COMPLEX BINDING FEATURE s127 a199 251
feature: COMPLEX BINDING FEATURE s127 a199 253
cellular location: Receiving cell c1

Complex (Patched/Hedgehog)
type: Complex
component stoichiometry: Patched s153 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: Hedgehog s3 sa2 STOICHIOMETRY ID COMPLEX
component: Hedgehog
component: Patched
feature: COMPLEX BINDING FEATURE s21 a30 223
feature: COMPLEX BINDING FEATURE s21 a30 221
cellular location: Receiving cell c1

uniprot G3V7F6 187
type: UnificationXref
id: G3V7F6
db: uniprot

Fused s34 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fused
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Cubitus_interruptus_Su_fu___Slimb_-_Ubiquitin-RIGHT__Complex__Su_fu__Slimb__Cubitus_interruptus_-_r40
controller: Ubiquitin ligase

uniprot F7FGS3 98
type: UnificationXref
id: F7FGS3
db: uniprot

Smoothened s37 sa18 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

STATE_TRANSITION_LEFT__Debra-RIGHT__Debra-_re25
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 328
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 329
left: Debra
interaction type: STATE_TRANSITION
right: Debra

Smoothened s17 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Smoothened
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Complex__Costal2_Fused__Smoothened_-RIGHT__Complex__Costal2_Fused__Smoothened_-_r14
controller: Complex (Patched/Hedgehog)

ACTIVE 113
type: EntityFeature
comment: Active state

uniprot P67962 31
type: UnificationXref
id: P67962
db: uniprot

uniprot F1PY87 155
type: UnificationXref
id: F1PY87
db: uniprot

Complex (Costal2/Fused/ Smoothened)
type: Complex
component stoichiometry: Costal2 s6 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Smoothened s11 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: Fused s8 sa6 STOICHIOMETRY ID COMPLEX
component: Costal2
component: Smoothened
component: Fused
feature: COMPLEX BINDING FEATURE s46 a55 283
feature: COMPLEX BINDING FEATURE s46 a55 287
feature: COMPLEX BINDING FEATURE s46 a55 285
cellular location: Receiving cell c1

Cubitus interruptus s19 sa26 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Cubitus interruptus s70 a223 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=1.65

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: uniprot P81900 74
xref: PTHR11635:SF162
organism: Drosophila melanogaster

E3 ubiquitin-protein ligase hyd
type: ProteinReference
xref: uniprot P51592 183
xref: PTHR46276:SF1
organism: Drosophila melanogaster

uniprot F6WM87 52
type: UnificationXref
id: F6WM87
db: uniprot

Cubitus interruptus s70 a46 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

Su(fu)
type: Protein
entity reference: Su(fu)
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa29 276
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r54 344
type: Stoichiometry
physical entity: CBP
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Costal2_Fused__Smoothened_-_ATP-RIGHT__Complex__Costal2_Smoothened__Fused_-_ADP-_r15
controller: Complex (Patched/Hedgehog)

E3 ubiquitin-protein ligase UBR5
type: ProteinReference
xref: uniprot Q80TP3 184
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HP77 146
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r8 310
type: Stoichiometry
physical entity: Complex (Patched/Hedgehog)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r54 345
type: Stoichiometry
physical entity: Cubitus interruptus
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r54 346
type: Stoichiometry
physical entity: Complex (CBP/Cubitus interruptus)
stoichiometric coefficient: 1.0

uniprot F6Q503 48
type: UnificationXref
id: F6Q503
db: uniprot

Cubitus interruptus s19 sa26 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.66

Cubitus interruptus s70 a223 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot F6Q9S4 49
organism: Bos taurus

Cubitus interruptus s70 a46 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=1.65

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Hedgehog_target_gene-RIGHT__Hedgehog_target_gene-_re24
control type: ACTIVATION
controller: Complex (CBP/Cubitus interruptus)

PARTICIPANT STOICHIOMETRY r8 309
type: Stoichiometry
physical entity: Complex (Patched/Hedgehog)
stoichiometric coefficient: 1.0

Casein kinase I
type: ProteinReference
xref: P00681
standard name: Casine kinase I
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Casine kinase I Synonym: CKI,Doubletime Accession: P00681
comment: ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Casein_space_kinase I
member entity reference: Casein kinase 1, alpha 1
member entity reference: Casein kinase I isoform alpha-like
member entity reference: Uncharacterized protein
member entity reference: Casein kinase 1 epsilon
member entity reference: Discs overgrown protein kinase
member entity reference: Casein kinase 1 alpha 1
member entity reference: Predicted protein
member entity reference: CSNK1A1L isoform 1
member entity reference: Casein kinase I isoform alpha
member entity reference: Casein kinase I isoform epsilon
member entity reference: Casein kinase I isoform alpha isoform 1
member entity reference: Casein kinase 1, epsilon

Cubitus interruptus s32 sa38 rs4
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=1.65

Su fu s35 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Su(fu)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r42 322
type: Stoichiometry
physical entity: Complex (Cubitus interruptus repressor/Su(fu))
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r42 323
type: Stoichiometry
physical entity: Complex (Cubitus interruptus repressor/Su(fu))
stoichiometric coefficient: 1.0

uniprot P47806 151
type: UnificationXref
id: P47806
db: uniprot

Histone deacetylase complex subunit SAP18
type: ProteinReference
xref: PTHR13082:SF0
xref: uniprot F7CXR4 186
organism: Macaca mulatta

Protein smoothened
type: ProteinReference
xref: uniprot P91682 109
xref: PTHR11309:SF35
organism: Drosophila melanogaster

eco ECO:0000250 8
type: UnificationXref
id: ECO:0000250
db: eco

PTHR11909:SF139
type: RelationshipXref
id: PTHR11909:SF139
db: PANTHER Family
relationship type: By Homology

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 81

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot H2RER5 55
organism: Pan troglodytes

Complex (Su(fu)/Cubitus interruptus)
type: Complex
component stoichiometry: Su fu s24 sa31 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cubitus interruptus s163 sa32 STOICHIOMETRY ID COMPLEX
component: Su(fu)
component: Cubitus interruptus
feature: COMPLEX BINDING FEATURE s103 a151 279
feature: COMPLEX BINDING FEATURE s103 a151 281
cellular location: Receiving cell c1

Complex (Su(fu)/Cubitus interruptus)
type: Complex
component stoichiometry: Su fu s20 sa29 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cubitus interruptus s23 sa30 STOICHIOMETRY ID COMPLEX
component: Su(fu)
component: Cubitus interruptus
feature: COMPLEX BINDING FEATURE s102 a150 275
feature: COMPLEX BINDING FEATURE s102 a150 277
cellular location: Receiving cell c1

Casein kinase I isoform alpha
type: ProteinReference
xref: uniprot P48729 27
xref: PTHR11909:SF84
organism: Homo sapiens

STATE_TRANSITION_LEFT__Complex__Costal2_Fused__Smoothened_-_ATP-RIGHT__Complex__Costal2_Smoothened__Fused_-_ADP-_r15
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 311
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 312
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 313
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 314
left: ATP
left: Complex (Costal2/Fused/ Smoothened)
interaction type: STATE_TRANSITION
right: ADP
right: Complex (Costal2/Smoothened/ Fused)

PTHR11909:SF18
type: RelationshipXref
id: PTHR11909:SF18
db: PANTHER Family
relationship type: By Homology

Cubitus interruptus s47 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cubitus interruptus
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot Q93372 173
organism: Caenorhabditis elegans

Su(fu)
type: ProteinReference
xref: P00699
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Su(fu)
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Suppressor of fused homolog

uniprot P10071 149
type: UnificationXref
id: P10071
db: uniprot

ncbitaxon 7165 81
type: UnificationXref
id: 7165
db: ncbitaxon

Complex (Costal2/Fused/ Smoothened)
type: Complex
component stoichiometry: Fused s16 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: Costal2 s15 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Smoothened s17 sa13 STOICHIOMETRY ID COMPLEX
component: Smoothened
component: Costal2
component: Fused
feature: COMPLEX BINDING FEATURE s69 a95 293
feature: COMPLEX BINDING FEATURE s69 a95 289
feature: COMPLEX BINDING FEATURE s69 a95 291
cellular location: membrane raft

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

ncbitaxon 7955 39
type: UnificationXref
id: 7955
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r25 343
type: Stoichiometry
physical entity: Complex (Costal2/Fused/ Smoothened)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r25 342
type: Stoichiometry
physical entity: Complex (Su(fu)/Cubitus interruptus)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r25 341
type: Stoichiometry
physical entity: Complex (Su(fu)/Fused/ Cubitus interruptus/Costal2/ Smoothened)
stoichiometric coefficient: 1.0

GO GO:0005768 5
type: UnificationXref
id: GO:0005768
db: GO

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PGQ1 168
xref: PTHR24057:SF8
organism: Monodelphis domestica

uniprot K7DBC8 158
type: UnificationXref
id: K7DBC8
db: uniprot

Hedgehog target gene
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

Protein patched homolog 1
type: ProteinReference
xref: uniprot Q90693 136
xref: PTHR46022:SF5
organism: Gallus gallus

Sin3A associated protein 18
type: ProteinReference
xref: uniprot F6R7D0 185
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: PTHR11635:SF126
xref: uniprot A0A1D5PCI4 43
organism: Gallus gallus

ncbitaxon 6239 70
type: UnificationXref
id: 6239
db: ncbitaxon

Sap18 s53 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Sap18
stoichiometric coefficient: 1.0

Protein patched homolog 1
type: ProteinReference
xref: uniprot Q09614 132
organism: Caenorhabditis elegans

Su(fu)
type: Protein
entity reference: Su(fu)
feature: COMPLEX PARTICIPANT BINDING FEATURE s40 sa20 242
cellular location: membrane raft
comment: SPECIES_TYPE=PROTEIN

uniprot F6VPH2 19
type: UnificationXref
id: F6VPH2
db: uniprot

uniprot Q09614 132
type: UnificationXref
id: Q09614
db: uniprot

Costal2 s12 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Costal2
stoichiometric coefficient: 1.0

eco ECO:0000304 62
type: UnificationXref
id: ECO:0000304
db: eco

uniprot E2QZT1 140
type: UnificationXref
id: E2QZT1
db: uniprot

Hedgehog protein
type: ProteinReference
xref: uniprot W4Y925 125
organism: Strongylocentrotus purpuratus

uniprot B8JIQ1 166
type: UnificationXref
id: B8JIQ1
db: uniprot

CREB-binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot Q6JHU9 160
organism: Rattus norvegicus

PTHR11635:SF162
type: RelationshipXref
id: PTHR11635:SF162
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

Suppressor of fused homolog
type: ProteinReference
xref: PTHR10928:SF2
xref: uniprot Q9UMX1 201
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__CBP-_Cubitus_interruptus-RIGHT__Complex__CBP_Cubitus_interruptus_-_r54
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 345
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 346
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 344
left: Cubitus interruptus
left: CBP
interaction type: HETERODIMER_ASSOCIATION
right: Complex (CBP/Cubitus interruptus)

uniprot P51592 183
type: UnificationXref
id: P51592
db: uniprot

P00681
type: UnificationXref
id: P00681
db: PANTHER Pathway Component

P00682
type: UnificationXref
id: P00682
db: PANTHER Pathway Component

Hedgehog protein
type: ProteinReference
xref: uniprot C3ZGW9 118
organism: Branchiostoma floridae

P00683
type: UnificationXref
id: P00683
db: PANTHER Pathway Component

Cubitus interruptus s32 sa38 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.66

P00685
type: UnificationXref
id: P00685
db: PANTHER Pathway Component

Casein kinase I isoform epsilon
type: ProteinReference
xref: uniprot Q9JMK2 42
xref: PTHR11909:SF18
organism: Mus musculus

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: uniprot A0A2I3SXI2 162
xref: PTHR24057:SF8
organism: Pan troglodytes

uniprot F1MD32 154
type: UnificationXref
id: F1MD32
db: uniprot

ncbitaxon 45351 12
type: UnificationXref
id: 45351
db: ncbitaxon

uniprot Q4V8C6 198
type: UnificationXref
id: Q4V8C6
db: uniprot

uniprot H9EPM1 170
type: UnificationXref
id: H9EPM1
db: uniprot

Cubitus interruptus
type: Protein
entity reference: Cubitus interruptus
feature: Cubitus interruptus s25 sa33 rs3
feature: Cubitus interruptus s25 sa33 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa33 230
feature: Cubitus interruptus s25 sa33 rs2
feature: Cubitus interruptus s25 sa33 rs4
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

Smoothened s11 sa7 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F1M9H1 141
type: UnificationXref
id: F1M9H1
db: uniprot

Fused
type: Protein
entity reference: Fused
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa12 292
feature: Fused s16 sa12 rs1
cellular location: membrane raft
comment: SPECIES_TYPE=PROTEIN

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 28

PTHR11635:SF156
type: RelationshipXref
id: PTHR11635:SF156
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r23 348
type: Stoichiometry
physical entity: Microtubule
stoichiometric coefficient: 1.0

PTHR11635:SF153
type: RelationshipXref
id: PTHR11635:SF153
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r23 347
type: Stoichiometry
physical entity: Complex (Costal2/Fused/ Su(fu)/Cubitus interruptus/ Smoothened/MIcrotubule)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 349
type: Stoichiometry
physical entity: Complex (Su(fu)/Fused/ Cubitus interruptus/Costal2/ Smoothened)
stoichiometric coefficient: 1.0

PTHR11635:SF152
type: RelationshipXref
id: PTHR11635:SF152
db: PANTHER Family
relationship type: By Homology

PTHR11909:SF20
type: RelationshipXref
id: PTHR11909:SF20
db: PANTHER Family
relationship type: By Homology

Cubitus interruptus s32 sa38 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

P00693
type: UnificationXref
id: P00693
db: PANTHER Pathway Component

P00691
type: UnificationXref
id: P00691
db: PANTHER Pathway Component

uniprot F7C1G3 21
type: UnificationXref
id: F7C1G3
db: uniprot

P00692
type: UnificationXref
id: P00692
db: PANTHER Pathway Component

P00690
type: UnificationXref
id: P00690
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r48 307
type: Stoichiometry
physical entity: Complex (Costal2/Fused/ Su(fu)/Cubitus interruptus/ Smoothened/MIcrotubule)
stoichiometric coefficient: 1.0

Smoothened
type: Protein
entity reference: Smoothened
feature: Smoothened s44 sa24 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s44 sa24 250
cellular location: membrane raft
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot F7HAK5 53
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r48 308
type: Stoichiometry
physical entity: Complex (Su(fu)/Cubitus interruptus)
stoichiometric coefficient: 1.0

P00689
type: UnificationXref
id: P00689
db: PANTHER Pathway Component

P00688
type: UnificationXref
id: P00688
db: PANTHER Pathway Component

P00687
type: UnificationXref
id: P00687
db: PANTHER Pathway Component

P00686
type: UnificationXref
id: P00686
db: PANTHER Pathway Component

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 84

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: uniprot O59922 57
xref: PTHR11635:SF152
organism: Emericella nidulans

Uncharacterized protein
type: ProteinReference
xref: PTHR45718:SF5
xref: uniprot F7GN18 145
organism: Macaca mulatta

Complex (Su(fu)/Slimb/ Cubitus interruptus)
type: Complex
component stoichiometry: Slimb s31 sa37 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cubitus interruptus s32 sa38 STOICHIOMETRY ID COMPLEX
component stoichiometry: Su fu s30 sa36 STOICHIOMETRY ID COMPLEX
component: Cubitus interruptus
component: Su(fu)
component: Slimb
feature: COMPLEX BINDING FEATURE s118 a183 267
feature: COMPLEX BINDING FEATURE s118 a183 269
feature: COMPLEX BINDING FEATURE s118 a183 265
cellular location: Receiving cell c1

Cubitus interruptus repressor
type: Protein
entity reference: Cubitus interruptus repressor
feature: COMPLEX PARTICIPANT BINDING FEATURE s150 sa41 256
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Costal2 s15 sa11 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Cubitus interruptus s32 sa38 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

PRKAR2A isoform 1
type: ProteinReference
xref: uniprot K7AEL3 56
xref: PTHR11635:SF153
organism: Pan troglodytes

uniprot F7DZP4 129
type: UnificationXref
id: F7DZP4
db: uniprot

uniprot Q9DBC7 82
type: UnificationXref
id: Q9DBC7
db: uniprot

Hedgehog protein
type: ProteinReference
xref: PTHR11889:SF36
xref: uniprot F1P3J4 120
organism: Gallus gallus

CREB binding protein
type: ProteinReference
xref: uniprot K7DBC8 158
xref: PTHR13808:SF34
organism: Pan troglodytes

P00698
type: UnificationXref
id: P00698
db: PANTHER Pathway Component

P00697
type: UnificationXref
id: P00697
db: PANTHER Pathway Component

GLI family zinc finger 3
type: ProteinReference
xref: uniprot F1M9H1 141
xref: PTHR45718:SF5
organism: Rattus norvegicus

P00699
type: UnificationXref
id: P00699
db: PANTHER Pathway Component

uniprot Q02936 122
type: UnificationXref
id: Q02936
db: uniprot

PARTICIPANT STOICHIOMETRY r51 298
type: Stoichiometry
physical entity: Sap18
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 299
type: Stoichiometry
physical entity: Complex (Sap18/Su(fu)/ Cubitus interruptus repressor)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 297
type: Stoichiometry
physical entity: Complex (Cubitus interruptus repressor/Su(fu))
stoichiometric coefficient: 1.0

Cubitus interruptus s32 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cubitus interruptus
stoichiometric coefficient: 1.0

PTHR11909:SF84
type: RelationshipXref
id: PTHR11909:SF84
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5QSK7 126
type: UnificationXref
id: A0A1D5QSK7
db: uniprot

uniprot K7AEL3 56
type: UnificationXref
id: K7AEL3
db: uniprot

DISSOCIATION_LEFT__Complex__Su_fu__Fused__Cubitus_interruptus_Costal2__Smoothened_-RIGHT__Complex__Su_fu__Cubitus_interruptus_-_Complex__Costal2_Fused__Smoothened_-_r25
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 341
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 343
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 342
left: Complex (Su(fu)/Fused/ Cubitus interruptus/Costal2/ Smoothened)
interaction type: DISSOCIATION
right: Complex (Su(fu)/Cubitus interruptus)
right: Complex (Costal2/Fused/ Smoothened)

TRANSCRIPTION
type: RelationshipTypeVocabulary

ncbitaxon 9913 50
type: UnificationXref
id: 9913
db: ncbitaxon

Protein CBG07560
type: ProteinReference
xref: uniprot A8X4K1 164
organism: Caenorhabditis briggsae

Complex (Cubitus interruptus repressor/Su(fu))
type: Complex
component stoichiometry: Cubitus interruptus repressor s150 sa41 STOICHIOMETRY ID COMPLEX
component stoichiometry: Su fu s52 sa42 STOICHIOMETRY ID COMPLEX
component: Cubitus interruptus repressor
component: Su(fu)
feature: COMPLEX BINDING FEATURE s128 a200 257
feature: COMPLEX BINDING FEATURE s128 a200 255
cellular location: nucleus

GSK3
type: ProteinReference
xref: P00692
standard name: Glycogen synthase kinase 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.GSK3
comment: ENTITY_REFERENCE_NOTES=Long Name: GSK3 Synonym: Glycogen synthase kinase3,Glycogen synthase kinase3 beta,sgg,shaggy,zeste-white 3 Accession: P00692
member entity reference: Uncharacterized protein
member entity reference: Glycogen synthase kinase 3 beta
member entity reference: Glycogen synthase kinase-3 beta
member entity reference: Protein CBG07560
member entity reference: Glycogen synthase kinase 3
member entity reference: Si:dkeyp-80c12.7
member entity reference: Glycogen synthase kinase-3 beta isoform 1

Ubiquitin protein ligase E3 component n-recognin 5
type: ProteinReference
xref: uniprot F1Q8J2 177
organism: Danio rerio

uniprot A0A2I3SMC0 88
type: UnificationXref
id: A0A2I3SMC0
db: uniprot

uniprot A0A3Q1M118 90
type: UnificationXref
id: A0A3Q1M118
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E9HGM4 13
xref: PTHR11909:SF20
organism: Daphnia pulex

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Slimb
type: Protein
entity reference: Slimb
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa37 268
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

Fused
type: Protein
entity reference: Fused
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa6 286
feature: Fused s8 sa6 rs1
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

PTHR11635:SF129
type: RelationshipXref
id: PTHR11635:SF129
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF126
type: RelationshipXref
id: PTHR11635:SF126
db: PANTHER Family
relationship type: By Homology

uniprot Q99PS2 41
type: UnificationXref
id: Q99PS2
db: uniprot

uniprot F6R812 17
type: UnificationXref
id: F6R812
db: uniprot

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 62

Cubitus interruptus s130 a202 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=1.65

Smoothened, frizzled class receptor
type: ProteinReference
xref: uniprot Q5RH73 111
xref: PTHR11309:SF35
organism: Danio rerio

TRANSPORT_LEFT__Complex__Su_fu__Cubitus_interruptus_-RIGHT__Cubitus_interruptus-_r56
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 340
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 339
left: Complex (Su(fu)/Cubitus interruptus)
interaction type: TRANSPORT
right: Cubitus interruptus

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 12

uniprot F6YUQ2 95
type: UnificationXref
id: F6YUQ2
db: uniprot

uniprot A0A3Q2TVV5 163
type: UnificationXref
id: A0A3Q2TVV5
db: uniprot

Fused
type: Protein
entity reference: Fused
feature: COMPLEX PARTICIPANT BINDING FEATURE s41 sa21 244
feature: Fused s41 sa21 rs1
cellular location: membrane raft
comment: SPECIES_TYPE=PROTEIN

Complex (Costal2/Smoothened/ Fused)
type: Complex
component stoichiometry: Costal2 s12 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: Fused s14 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: Smoothened s13 sa9 STOICHIOMETRY ID COMPLEX
component: Smoothened
component: Costal2
component: Fused
feature: COMPLEX BINDING FEATURE s48 a57 259
feature: COMPLEX BINDING FEATURE s48 a57 263
feature: COMPLEX BINDING FEATURE s48 a57 261
cellular location: Receiving cell c1

Cubitus interruptus s130 a202 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

ncbitaxon 8364 20
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot Q61602 153
type: UnificationXref
id: Q61602
db: uniprot

STK36 isoform 2
type: ProteinReference
xref: uniprot K7DNJ5 115
organism: Pan troglodytes

Probable histone deacetylase complex subunit SAP18
type: ProteinReference
xref: uniprot Q09250 190
organism: Caenorhabditis elegans

uniprot E9HGM4 13
type: UnificationXref
id: E9HGM4
db: uniprot

uniprot F6Q9S4 49
type: UnificationXref
id: F6Q9S4
db: uniprot

Cubitus interruptus
type: ProteinReference
xref: P00690
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Cubitus_space_interruptus
comment: ENTITY_REFERENCE_NOTES=Long Name: Cubitus interruptus Synonym: Ci,CiFL,Gli1,Gli2,Gli3 Accession: P00690
member entity reference: Transcriptional activator GLI3
member entity reference: Transcriptional activator cubitus interruptus
member entity reference: GLI family zinc finger 3
member entity reference: GLI family zinc finger 1
member entity reference: GLI1 protein
member entity reference: Zinc finger protein GLI1
member entity reference: Uncharacterized protein
member entity reference: GLI family zinc finger 2a

Cubitus interruptus s130 a202 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Fused s8 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fused
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

CREB-binding protein
type: ProteinReference
xref: uniprot P45481 159
xref: PTHR13808:SF34
organism: Mus musculus

Fused s16 sa12 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

PARTICIPANT STOICHIOMETRY r56 339
type: Stoichiometry
physical entity: Complex (Su(fu)/Cubitus interruptus)
stoichiometric coefficient: 1.0

CSNK1A1L isoform 1
type: ProteinReference
xref: PTHR11909:SF139
xref: uniprot H2REV2 22
organism: Pan troglodytes

Cubitus interruptus s36 sa17 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.66

PTHR13808:SF34
type: RelationshipXref
id: PTHR13808:SF34
db: PANTHER Family
relationship type: By Homology

a31_degraded
type: PhysicalEntity
cellular location: Receiving cell c1
comment: SPECIES_TYPE=DEGRADED

Smoothened s17 sa13 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q7PPI8 80
type: UnificationXref
id: Q7PPI8
db: uniprot

Protein patched
type: ProteinReference
xref: PTHR46022:SF1
xref: uniprot P18502 130
organism: Drosophila melanogaster

Sonic hedgehog protein A
type: ProteinReference
xref: uniprot Q92008 124
xref: PTHR11889:SF36
organism: Danio rerio

Cubitus interruptus s130 a202 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.66

uniprot E2RAI7 196
type: UnificationXref
id: E2RAI7
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

PARTICIPANT STOICHIOMETRY r56 340
type: Stoichiometry
physical entity: Cubitus interruptus
stoichiometric coefficient: 1.0

uniprot P00515 60
type: UnificationXref
id: P00515
db: uniprot

Cubitus interruptus s36 sa17 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

TRANSPORT_LEFT__Complex__Su_fu__Cubitus_interruptus_-RIGHT__Cubitus_interruptus-_r26
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 337
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 338
left: Complex (Su(fu)/Cubitus interruptus)
interaction type: TRANSPORT
right: Cubitus interruptus

Casein kinase I isoform alpha
type: ProteinReference
xref: uniprot P67962 31
xref: PTHR11909:SF20
organism: Gallus gallus

Smoothened
type: Protein
entity reference: Smoothened
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa7 288
feature: Smoothened s11 sa7 rs1
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

Microtubule
type: Protein
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

Hedgehog s5 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Hedgehog
stoichiometric coefficient: 1.0

Casein kinase I isoform alpha
type: ProteinReference
xref: uniprot Q8BK63 36
xref: PTHR11909:SF20
organism: Mus musculus

Cubitus interruptus
type: Protein
entity reference: Cubitus interruptus
feature: Cubitus interruptus s19 sa26 rs3
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa26 274
feature: Cubitus interruptus s19 sa26 rs1
feature: Cubitus interruptus s19 sa26 rs4
feature: Cubitus interruptus s19 sa26 rs2
cellular location: Receiving cell c1
comment: SPECIES_TYPE=PROTEIN

KNOWN_TRANSITION_OMITTED
type: InteractionVocabulary

uniprot Q9WV60 174
type: UnificationXref
id: Q9WV60
db: uniprot

PARTICIPANT STOICHIOMETRY r14 319
type: Stoichiometry
physical entity: Complex (Costal2/Fused/ Smoothened)
stoichiometric coefficient: 1.0

uniprot Q09250 190
type: UnificationXref
id: Q09250
db: uniprot

Suppressor of fused homolog
type: ProteinReference
xref: PTHR10928:SF2
xref: uniprot F6RMT7 197
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r14 318
type: Stoichiometry
physical entity: Complex (Costal2/Fused/ Smoothened)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r26 337
type: Stoichiometry
physical entity: Complex (Su(fu)/Cubitus interruptus)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r26 338
type: Stoichiometry
physical entity: Cubitus interruptus
stoichiometric coefficient: 1.0

uniprot F7ACT4 169
type: UnificationXref
id: F7ACT4
db: uniprot

PTHR19849:SF1
type: RelationshipXref
id: PTHR19849:SF1
db: PANTHER Family
relationship type: By Homology

uniprot F6R7N8 51
type: UnificationXref
id: F6R7N8
db: uniprot

Cubitus interruptus s36 sa17 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

Cubitus interruptus repressor s151 sa45 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cubitus interruptus repressor
stoichiometric coefficient: 1.0

Suppressor of fused homolog
type: ProteinReference
xref: PTHR10928:SF2
xref: uniprot Q4V8C6 198
organism: Rattus norvegicus

CBP
type: Protein
entity reference: CBP
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r44 321
type: Stoichiometry
physical entity: a202_degraded
stoichiometric coefficient: 1.0

Beta-transducin repeat containing E3 ubiquitin protein ligase
type: ProteinReference
xref: PTHR44156:SF2
xref: uniprot A0A1D5P3W6 87
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r44 320
type: Stoichiometry
physical entity: Cubitus interruptus
stoichiometric coefficient: 1.0

Fused s41 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fused
stoichiometric coefficient: 1.0

Cubitus interruptus s36 sa17 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=1.65

ncbitaxon 9606 28
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot K7DNJ5 115
type: UnificationXref
id: K7DNJ5
db: uniprot

Smoothened, frizzled class receptor
type: ProteinReference
xref: uniprot H2QVC7 107
xref: PTHR11309:SF35
organism: Pan troglodytes

Complex (Su(fu)/Cubitus interruptus)
type: Complex
component stoichiometry: Su fu s18 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cubitus interruptus s19 sa26 STOICHIOMETRY ID COMPLEX
component: Su(fu)
component: Cubitus interruptus
feature: COMPLEX BINDING FEATURE s89 a124 273
feature: COMPLEX BINDING FEATURE s89 a124 271
cellular location: Receiving cell c1

Smoothened s44 sa24 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

F-box/WD repeat-containing protein 1A
type: ProteinReference
xref: uniprot Q3ULA2 100
xref: PTHR44156:SF2
organism: Mus musculus