MODEL_NOTES=Panther Pathway: P00025 This is the current model for the Hedgehog signaling pathway. The best data for mechanism of signaling has been worked out in Drosophila, so this model is based largely on Drosophila data. Hedgehog target genes vary from tissue to tissue, so the identities of individual target genes have not been listed. The main difference between the Drosophila and mammalian Hedgehog signaling pathways is the fact that there are three mammalian homologs of Cubitus interruptus, Gli1 Gli2 and Gli3. Some or all of the mammalian homologs may be proteolytically processed, but the data are controversial. There are two mammalian Ptc genes and three mammalian Hedgehog genes as well. The pathway for Sonic Hedgehog appears to be most similar to the Drosophila hedgehog pathway. Medline=11731473 Medline=11861165 Medline=12200154 Medline=14738752 PMID: 11731473 PMID: 11861165 PMID: 12200154 PMID: 14738752
Complex (Sap18/Su(fu)/ Cubitus interruptus repressor)
Beta-transducin repeat-containing E3 ubiquitin protein ligase
Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
Transcriptional activator cubitus interruptus
F-box and WD repeat domain-containing 11b
Protein kinase cAMP-dependent type II regulatory subunit alpha
Protein kinase cAMP-dependent type I regulatory subunit alpha
cAMP-dependent protein kinase regulatory subunit
Complex (Su(fu)/Fused/ Cubitus interruptus/Costal2/ Smoothened)
cAMP-dependent protein kinase type I-beta regulatory subunit
F-box and WD repeat domain containing 11
cAMP-dependent protein kinase type I-alpha regulatory subunit
Complex (Costal2/Fused/ Su(fu)/Cubitus interruptus/ Smoothened/MIcrotubule)
cAMP-dependent protein kinase type II-beta regulatory subunit
cAMP-dependent protein kinase type II regulatory subunit
ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Slimb
ENTITY_REFERENCE_NOTES=Long Name: Slimb Synonym: Supernumerary limbs,beta TRCP,beta transducin Accession: P00683
Glycogen synthase kinase-3 beta isoform 1
cAMP-dependent protein kinase type II-alpha regulatory subunit
Ubiquitin protein ligase E3 component n-recognin 5
Complex (Cubitus interruptus/Su(fu)/ Slimb)
F-box and WD repeat domain-containing 11
Protein kinase cAMP-dependent type II regulatory subunit beta
ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Fused
Histone deacetylase complex subunit SAP18
ENTITY_REFERENCE_NOTES=Long Name: PKA Synonym: Protein kinase A,cAMP-dependent Protein Kinase A Accession: P00682
ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.PKA
ENTITY_REFERENCE_NOTES=Long Name: CBP Synonym: CREB binding protein,p300 Accession: P00691
ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.CBP
cAMP-dependent protein kinase type I regulatory subunit
ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Ubiquitin_space_ligase
ENTITY_REFERENCE_NOTES=Long Name: Ubiquitin ligase Synonym: Synonym not specified Accession: P00693
ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.RECEPTOR.Patched
ENTITY_REFERENCE_NOTES=Long Name: Patched Synonym: Ptc,Ptc1 Accession: P00689
ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Costal2
Protein kinase, cAMP-dependent, regulatory, type I, beta
Beta-transducin repeat containing E3 ubiquitin protein ligase
ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.RECEPTOR.Smoothened
ENTITY_REFERENCE_NOTES=Long Name: Sap18 Synonym: Sin3-associated polypeptide 18 Accession: P00697
ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Sap18
ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.TRUNCATED.Cubitus_br_interruptus_br_repressor
ENTITY_REFERENCE_NOTES=Long Name: Hedgehog Synonym: Hh,Shh,Sonic hedgehog Accession: P00688
ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Hedgehog
Complex (Cubitus interruptus repressor/Su(fu))
ENTITY_REFERENCE_NOTES=Long Name: Casine kinase I Synonym: CKI,Doubletime Accession: P00681
ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Casein_space_kinase I
ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Su(fu)
Complex (Su(fu)/Slimb/ Cubitus interruptus)
ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.GSK3
ENTITY_REFERENCE_NOTES=Long Name: GSK3 Synonym: Glycogen synthase kinase3,Glycogen synthase kinase3 beta,sgg,shaggy,zeste-white 3 Accession: P00692
Probable histone deacetylase complex subunit SAP18
ENTITY_REFERENCE_ID_DESC=Hedgehog signaling pathway.PROTEIN.GENERIC.Cubitus_space_interruptus
ENTITY_REFERENCE_NOTES=Long Name: Cubitus interruptus Synonym: Ci,CiFL,Gli1,Gli2,Gli3 Accession: P00690