Porphobilinogen deaminase
type: ProteinReference
xref: uniprot P08397 291
organism: Homo sapiens

uniprot O86528 144
type: UnificationXref
id: O86528
db: uniprot

uniprot Q869Z3 167
type: UnificationXref
id: Q869Z3
db: uniprot

PARTICIPANT STOICHIOMETRY r2 319
type: Stoichiometry
physical entity: tRNAglu
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 318
type: Stoichiometry
physical entity: glutamate-1-semialdehyde
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 317
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Protoheme IX farnesyltransferase
type: ProteinReference
xref: uniprot Q79EF2 273
organism: Synechocystis

PARTICIPANT STOICHIOMETRY r2 316
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 315
type: Stoichiometry
physical entity: glutamyl-tRNAglu
stoichiometric coefficient: 1.0

Uroporphyrinogen-III synthase
type: Protein
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 284812 48
type: UnificationXref
id: 284812
db: ncbitaxon

Protoporphyrinogen oxidase
type: ProteinReference
xref: uniprot P56602 124
organism: Bos taurus

uniprot Q9I719 279
type: UnificationXref
id: Q9I719
db: uniprot

uniprot Q8ZU33 175
type: UnificationXref
id: Q8ZU33
db: uniprot

5-amino-levulinate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CPOX isoform 1
type: ProteinReference
xref: uniprot H2QMZ9 228
organism: Pan troglodytes

uniprot Q8ZYW1 257
type: UnificationXref
id: Q8ZYW1
db: uniprot

uniprot Q8S5M6 172
type: UnificationXref
id: Q8S5M6
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 21

STATE_TRANSITION_LEFT__SAM-_uroporphyrinogen_III-RIGHT__SA_homocysteine-_dihydrosirohydrochlorin-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 362
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 364
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 363
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 365
left: uroporphyrinogen-III
left: SAM
interaction type: STATE_TRANSITION
right: SA-homocysteine
right: dihydrosirohydrochlorin

2 H2O2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot P29680 102
organism: Escherichia coli

Glutamate-1-semialdehyde 2,1-aminomutase 2
type: ProteinReference
xref: uniprot P71084 249
organism: Bacillus subtilis

Ferrochelatase
type: ProteinReference
xref: uniprot O84492 50
organism: Chlamydia trachomatis

uniprot O31652 264
type: UnificationXref
id: O31652
db: uniprot

Protoporphyrinogen oxidase
type: Protein
entity reference: Protoporphyrinogen oxidase
comment: SPECIES_TYPE=PROTEIN

uniprot Q9XCL6 190
type: UnificationXref
id: Q9XCL6
db: uniprot

uniprot Q5SUV1 20
type: UnificationXref
id: Q5SUV1
db: uniprot

Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
type: ProteinReference
xref: uniprot Q3B7D0 235
organism: Rattus norvegicus

Uroporphyrinogen III synthase/methyltransferase
type: ProteinReference
xref: uniprot Q7UPD0 82
organism: Rhodopirellula baltica

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot Q9RSG4 224
organism: Deinococcus radiodurans

Glutamate-1-semialdehyde 2,1-aminomutase
type: ProteinReference
xref: uniprot Q9RWW0 260
organism: Deinococcus radiodurans

STATE_TRANSITION_LEFT__uroporphyrinogen_III-RIGHT__coproporphyrinogen_III-_4__CO2-_r11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 349
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 348
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 347
left: uroporphyrinogen-III
interaction type: STATE_TRANSITION
right: 4 CO2
right: coproporphyrinogen III

Uroporphyrinogen decarboxylase
type: Protein
entity reference: Uroporphyrinogen decarboxylase
comment: SPECIES_TYPE=PROTEIN

uniprot P22830 56
type: UnificationXref
id: P22830
db: uniprot

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot O69861 99
organism: Streptomyces coelicolor

uniprot Q42522 251
type: UnificationXref
id: Q42522
db: uniprot

uniprot Q9X2I8 189
type: UnificationXref
id: Q9X2I8
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 81

uniprot Q6YZE2 254
type: UnificationXref
id: Q6YZE2
db: uniprot

Ferrochelatase
type: ProteinReference
xref: uniprot F6ZKY9 42
organism: Macaca mulatta

Ferrochelatase, mitochondrial
type: ProteinReference
xref: uniprot Q3YA36 64
organism: Pan troglodytes

Probable glutamine--tRNA ligase
type: ProteinReference
xref: uniprot Q9Y105 191
organism: Drosophila melanogaster

ncbitaxon 9031 45
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot Q7UPD0 82
type: UnificationXref
id: Q7UPD0
db: uniprot

uniprot P28602 57
type: UnificationXref
id: P28602
db: uniprot

Glutamate-1-semialdehyde 2,1-aminomutase
type: ProteinReference
xref: uniprot Q58020 253
organism: Methanocaldococcus jannaschii

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SAM-_uroporphyrinogen_III-RIGHT__SA_homocysteine-_dihydrosirohydrochlorin-_r7
controller: Uroporphyrinogen methyltransferase

uniprot O66667 98
type: UnificationXref
id: O66667
db: uniprot

ncbitaxon 83333 13
type: UnificationXref
id: 83333
db: ncbitaxon

uniprot O04921 43
type: UnificationXref
id: O04921
db: uniprot

uniprot Q9RWW0 260
type: UnificationXref
id: Q9RWW0
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 7

uniprot P0AEA5 267
type: UnificationXref
id: P0AEA5
db: uniprot

NADH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P30949 246
type: UnificationXref
id: P30949
db: uniprot

Glutamyl-Q tRNA(Asp) synthetase
type: ProteinReference
xref: uniprot P27305 150
organism: Escherichia coli

uniprot K8ES01 263
type: UnificationXref
id: K8ES01
db: uniprot

Glutamate--tRNA ligase
type: ProteinReference
xref: uniprot Q58772 160
organism: Methanocaldococcus jannaschii

Glutamate-1-semialdehyde aminotransferase
type: ProteinReference
xref: P02981
standard name: Glutamate-1-semialdehyde 2,1-aminomutase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Glutamate-1-semialdehyde 2,1-aminomutase Synonym: Synonym not specified Accession: P02981
comment: ENTITY_REFERENCE_ID_DESC=Heme biosynthesis.PROTEIN.GENERIC.Glutamate-1-semialdehyde_br_aminotransferase
member entity reference: Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic
member entity reference: Uncharacterized aminotransferase C417.11c
member entity reference: Glutamate-1-semialdehyde 2,1-aminomutase
member entity reference: Glutamate-1-semialdehyde 2,1-aminomutase 2
member entity reference: Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic
member entity reference: Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic
member entity reference: Glutamate-1-semialdehyde aminotransferase

Os01g0185200 protein
type: ProteinReference
xref: uniprot Q5VRX8 163
organism: Oryza sativa

uniprot Q9Y7Y4 284
type: UnificationXref
id: Q9Y7Y4
db: uniprot

uniprot O66621 287
type: UnificationXref
id: O66621
db: uniprot

uniprot Q8ZYW7 304
type: UnificationXref
id: Q8ZYW7
db: uniprot

Protoporphyrinogen oxidase
type: ProteinReference
xref: P02976
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protoporphyrinogen oxidase Synonym: Synonym not specified Accession: P02976
comment: ENTITY_REFERENCE_ID_DESC=Heme biosynthesis.PROTEIN.GENERIC.Protoporphyrinogen oxidase
member entity reference: L-amino acid oxidase
member entity reference: Protoporphyrinogen oxidase

AGAP002945-PA
type: ProteinReference
xref: uniprot Q7PRA2 164
organism: Anopheles gambiae

uniprot P9WMN9 250
type: UnificationXref
id: P9WMN9
db: uniprot

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot P10518 205
organism: Mus musculus

Protoheme IX farnesyltransferase, mitochondrial
type: ProteinReference
xref: uniprot K8ES01 263
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r9 357
type: Stoichiometry
physical entity: siroheme
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 356
type: Stoichiometry
physical entity: 2 H+
stoichiometric coefficient: 1.0

uniprot P08397 291
type: UnificationXref
id: P08397
db: uniprot

PARTICIPANT STOICHIOMETRY r9 355
type: Stoichiometry
physical entity: sirohydrochlorin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 354
type: Stoichiometry
physical entity: Fe2+
stoichiometric coefficient: 1.0

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot A0A2I3RKG7 193
organism: Pan troglodytes

Uroporphyrinogen-III C-methyltransferase
type: ProteinReference
xref: uniprot P42437 75
organism: Bacillus subtilis

Porphobilinogen deaminase
type: ProteinReference
xref: uniprot O66621 287
organism: Aquifex aeolicus

Probable porphobilinogen deaminase
type: ProteinReference
xref: uniprot O84301 288
organism: Chlamydia trachomatis

uniprot Q3YA36 64
type: UnificationXref
id: Q3YA36
db: uniprot

uniprot Q60169 301
type: UnificationXref
id: Q60169
db: uniprot

uniprot Q7QCD2 166
type: UnificationXref
id: Q7QCD2
db: uniprot

glutamyl-tRNAglu
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 188937 88
type: UnificationXref
id: 188937
db: ncbitaxon

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot Q9PTS2 113
organism: Danio rerio

Glutamate--tRNA ligase, cytoplasmic
type: ProteinReference
xref: uniprot O82462 142
organism: Arabidopsis thaliana

Oxygen-dependent coproporphyrinogen-III oxidase
type: ProteinReference
xref: uniprot P11353 229
organism: Saccharomyces cerevisiae

Protoheme IX farnesyltransferase, mitochondrial
type: ProteinReference
xref: uniprot Q9Y7Y4 284
organism: Schizosaccharomyces pombe

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__uroporphyrinogen_III-RIGHT__coproporphyrinogen_III-_4__CO2-_r11
controller: Uroporphyrinogen decarboxylase

Glutamate--tRNA ligase
type: ProteinReference
xref: uniprot P04805 146
organism: Escherichia coli

Probable glutamine--tRNA ligase
type: ProteinReference
xref: uniprot Q9Y7Y8 192
organism: Schizosaccharomyces pombe

Protoheme IX farnesyltransferase, mitochondrial
type: ProteinReference
xref: uniprot P21592 268
organism: Saccharomyces cerevisiae

uniprot Q93Z96 236
type: UnificationXref
id: Q93Z96
db: uniprot

Coproporphyrinogen Oxidase (oxygen dependent)
type: Protein
entity reference: Coproporphyrinogen Oxidase (oxygen dependent)
comment: SPECIES_TYPE=PROTEIN

Glutamate--tRNA ligase, mitochondrial
type: ProteinReference
xref: uniprot Q9HDX9 179
organism: Schizosaccharomyces pombe

Protoheme IX farnesyltransferase
type: ProteinReference
xref: uniprot Q9XAC2 283
organism: Streptomyces coelicolor

uniprot A8I980 194
type: UnificationXref
id: A8I980
db: uniprot

uniprot Q9RM98 280
type: UnificationXref
id: Q9RM98
db: uniprot

uniprot P10518 205
type: UnificationXref
id: P10518
db: uniprot

uniprot Q8RG58 219
type: UnificationXref
id: Q8RG58
db: uniprot

Glutamate--tRNA ligase
type: ProteinReference
xref: uniprot Q8RDZ8 171
organism: Fusobacterium nucleatum

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 15

uniprot Q9I6A9 28
type: UnificationXref
id: Q9I6A9
db: uniprot

PARTICIPANT STOICHIOMETRY r8 360
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 361
type: Stoichiometry
physical entity: sirohydrochlorin
stoichiometric coefficient: 1.0

uniprot O69861 99
type: UnificationXref
id: O69861
db: uniprot

uniprot F6WU54 120
type: UnificationXref
id: F6WU54
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 5

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot Q7NEK2 107
organism: Gloeobacter violaceus

Ferrochelatase
type: ProteinReference
xref: uniprot Q9RV98 68
organism: Deinococcus radiodurans

uniprot O84638 201
type: UnificationXref
id: O84638
db: uniprot

uniprot P00962 145
type: UnificationXref
id: P00962
db: uniprot

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot Q9RV96 114
organism: Deinococcus radiodurans

ncbitaxon 7165 66
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot O64886 265
type: UnificationXref
id: O64886
db: uniprot

uniprot Q7QG25 65
type: UnificationXref
id: Q7QG25
db: uniprot

Glutamate--tRNA ligase
type: ProteinReference
xref: uniprot Q55778 159
organism: Synechocystis

Physcomitrella patens
type: BioSource
xref: ncbitaxon 3218 197

P02980
type: UnificationXref
id: P02980
db: PANTHER Pathway Component

P02981
type: UnificationXref
id: P02981
db: PANTHER Pathway Component

P02982
type: UnificationXref
id: P02982
db: PANTHER Pathway Component

ncbitaxon 243274 35
type: UnificationXref
id: 243274
db: ncbitaxon

P02983
type: UnificationXref
id: P02983
db: PANTHER Pathway Component

Radical S-adenosyl methionine domain-containing protein
type: ProteinReference
xref: uniprot F7HBT8 4
organism: Macaca mulatta

uniprot H2QMZ9 228
type: UnificationXref
id: H2QMZ9
db: uniprot

uniprot Q9VKZ1 282
type: UnificationXref
id: Q9VKZ1
db: uniprot

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 88

STATE_TRANSITION_LEFT__2__O2-_NADPH-_coproporphyrinogen_III-RIGHT__2__CO2-_NADP-_protoporphyrinogen-_2__H2O2-_r13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 343
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 341
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 342
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 340
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 339
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 344
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 338
left: NADPH
left: coproporphyrinogen III
left: 2 O2
interaction type: STATE_TRANSITION
right: 2 H2O2
right: protoporphyrinogen
right: 2 CO2
right: NADP

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: P02975
comment: ENTITY_REFERENCE_ID_DESC=Heme biosynthesis.PROTEIN.GENERIC.Uroporphyrinogen decarboxylase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Uroporphyrinogen decarboxylase Synonym: Synonym not specified Accession: P02975
member entity reference: Uroporphyrinogen decarboxylase
member entity reference: Uroporphyrinogen decarboxylase 2, chloroplastic
member entity reference: Precorrin methylase
member entity reference: Uroporphyrinogen decarboxylase 1, chloroplastic

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot Q9USJ5 115
organism: Schizosaccharomyces pombe

PARTICIPANT STOICHIOMETRY r8 359
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

uniprot Q9HVD7 67
type: UnificationXref
id: Q9HVD7
db: uniprot

PARTICIPANT STOICHIOMETRY r8 358
type: Stoichiometry
physical entity: dihydrosirohydrochlorin
stoichiometric coefficient: 1.0

P02975
type: UnificationXref
id: P02975
db: PANTHER Pathway Component

P02977
type: UnificationXref
id: P02977
db: PANTHER Pathway Component

P02976
type: UnificationXref
id: P02976
db: PANTHER Pathway Component

P02979
type: UnificationXref
id: P02979
db: PANTHER Pathway Component

uniprot P47897 153
type: UnificationXref
id: P47897
db: uniprot

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 9

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_porphobilinogen-RIGHT__NH3-_hydroxymethylbilane-_r10
controller: Hydroxymethylbilane synthase

P02972
type: UnificationXref
id: P02972
db: PANTHER Pathway Component

P02973
type: UnificationXref
id: P02973
db: PANTHER Pathway Component

P02970
type: UnificationXref
id: P02970
db: PANTHER Pathway Component

uniprot P9WFR7 270
type: UnificationXref
id: P9WFR7
db: uniprot

uniprot P54225 60
type: UnificationXref
id: P54225
db: uniprot

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot O66667 98
organism: Aquifex aeolicus

uniprot Q93YP7 276
type: UnificationXref
id: Q93YP7
db: uniprot

ncbitaxon 3218 197
type: UnificationXref
id: 3218
db: ncbitaxon

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot Q9HMZ1 223
organism: Halobacterium salinarum

uniprot P42437 75
type: UnificationXref
id: P42437
db: uniprot

PARTICIPANT STOICHIOMETRY r16 326
type: Stoichiometry
physical entity: FDP
stoichiometric coefficient: 1.0

Probable porphobilinogen deaminase
type: ProteinReference
xref: uniprot Q9HMY5 305
organism: Halobacterium salinarum

PARTICIPANT STOICHIOMETRY r16 328
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r16 327
type: Stoichiometry
physical entity: protoheme
stoichiometric coefficient: 1.0

Glutamate-1-semialdehyde 2,1-aminomutase
type: ProteinReference
xref: uniprot Q9HMY8 259
organism: Halobacterium salinarum

Protoheme IX farnesyltransferase
type: ProteinReference
xref: uniprot Q9HRJ8 277
organism: Halobacterium salinarum

Porphobilinogen deaminase isoform 1
type: ProteinReference
xref: uniprot F6U3X9 286
organism: Macaca mulatta

Bradyrhizobium diazoefficiens
type: BioSource
xref: ncbitaxon 224911 58

PARTICIPANT STOICHIOMETRY r16 329
type: Stoichiometry
physical entity: Heme
stoichiometric coefficient: 1.0

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 176

NADPH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Protoheme IX farnesyltransferase 2
type: ProteinReference
xref: uniprot Q9I423 278
organism: Pseudomonas aeruginosa

uniprot Q09899 298
type: UnificationXref
id: Q09899
db: uniprot

PARTICIPANT STOICHIOMETRY r4 311
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 312
type: Stoichiometry
physical entity: porphobilinogen
stoichiometric coefficient: 1.0

uniprot Q8RFP6 86
type: UnificationXref
id: Q8RFP6
db: uniprot

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 31

STATE_TRANSITION_LEFT__coproporphyrinogen_III-RIGHT__protoporphyrinogen-_r12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 345
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 346
left: coproporphyrinogen III
interaction type: STATE_TRANSITION
right: protoporphyrinogen

Glutamate-1-semialdehyde 2,1-aminomutase
type: ProteinReference
xref: uniprot P9WMN9 250
organism: Mycobacterium tuberculosis

Glutamate--tRNA ligase
type: ProteinReference
xref: uniprot P9WFV9 156
organism: Mycobacterium tuberculosis

uniprot P36150 74
type: UnificationXref
id: P36150
db: uniprot

uniprot Q9XAC2 283
type: UnificationXref
id: Q9XAC2
db: uniprot

Protoporphyrinogen oxidase
type: ProteinReference
xref: uniprot F6WU54 120
organism: Macaca mulatta

uniprot P42799 247
type: UnificationXref
id: P42799
db: uniprot

Probable uroporphyrinogen-III C-methyltransferase
type: ProteinReference
xref: uniprot O74468 73
organism: Schizosaccharomyces pombe

PARTICIPANT STOICHIOMETRY r4 310
type: Stoichiometry
physical entity: 5-amino-levulinate
stoichiometric coefficient: 1.0

uniprot Q8TT52 173
type: UnificationXref
id: Q8TT52
db: uniprot

uniprot P28668 151
type: UnificationXref
id: P28668
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 195

PARTICIPANT STOICHIOMETRY r11 349
type: Stoichiometry
physical entity: 4 CO2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 348
type: Stoichiometry
physical entity: coproporphyrinogen III
stoichiometric coefficient: 1.0

Coproporphyrinigen III oxidase, putative (Fragment)
type: ProteinReference
xref: uniprot B7PXP0 2
organism: Ixodes scapularis

Glutamyl(E) Amino-acyl tRNA Synthetase
type: ProteinReference
xref: uniprot Q23315 157
organism: Caenorhabditis elegans

Heme chaperone HemW
type: ProteinReference
xref: uniprot P9WP73 18
organism: Mycobacterium tuberculosis

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot P9WMP5 212
organism: Mycobacterium tuberculosis

Porphobilinogen deaminase
type: ProteinReference
xref: uniprot P9WMP3 297
organism: Mycobacterium tuberculosis

PARTICIPANT STOICHIOMETRY r11 347
type: Stoichiometry
physical entity: uroporphyrinogen-III
stoichiometric coefficient: 1.0

uniprot Q8ZYW5 221
type: UnificationXref
id: Q8ZYW5
db: uniprot

uniprot O13775 137
type: UnificationXref
id: O13775
db: uniprot

Porphobilinogen deaminase
type: ProteinReference
xref: uniprot P22907 294
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6R4X7 133
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__hydroxymethylbilane-RIGHT__H2O-_uroporphyrinogen_III-_r6
controller: Uroporphyrinogen-III synthase

uniprot Q8RFY7 255
type: UnificationXref
id: Q8RFY7
db: uniprot

uniprot H2QDF3 6
type: UnificationXref
id: H2QDF3
db: uniprot

Glutamyl-tRNA-synthetase
type: Protein
entity reference: Glutamyl-tRNA-synthetase
comment: SPECIES_TYPE=PROTEIN

Protoheme IX farnesyl transferase
type: Protein
entity reference: Protoheme IX farnesyl transferase
comment: SPECIES_TYPE=PROTEIN

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 139

porphobilinogen synthase
type: Protein
entity reference: porphobilinogen synthase
comment: SPECIES_TYPE=PROTEIN

uniprot F7FTL6 261
type: UnificationXref
id: F7FTL6
db: uniprot

ncbitaxon 6239 139
type: UnificationXref
id: 6239
db: ncbitaxon

Coproporphyrinogen Oxidase (oxygen dependent)
type: ProteinReference
xref: P02980
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Heme biosynthesis.PROTEIN.GENERIC.Coproporphyrinogen Oxidase_br_(oxygen dependent)
comment: ENTITY_REFERENCE_NOTES=Long Name: Coproporphyrinogen Oxidase (oxygen dependent) Synonym: Synonym not specified Accession: P02980
member entity reference: Oxygen-dependent coproporphyrinogen-III oxidase
member entity reference: Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
member entity reference: Coproporphyrinogen III oxidase
member entity reference: CPOX isoform 1
member entity reference: Probable oxygen-dependent coproporphyrinogen-III oxidase
member entity reference: Coproporphyrinogen-III oxidase 1, chloroplastic
member entity reference: Coproporphyrinogen-III oxidase 2, chloroplastic

Glutamate--tRNA ligase
type: ProteinReference
xref: uniprot Q9RX30 186
organism: Deinococcus radiodurans

uniprot P22315 53
type: UnificationXref
id: P22315
db: uniprot

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot F7GY51 199
organism: Macaca mulatta

AGAP010267-PA
type: ProteinReference
xref: uniprot Q7Q0M3 165
organism: Anopheles gambiae

PARTICIPANT STOICHIOMETRY r1 325
type: Stoichiometry
physical entity: glutamyl-tRNAglu
stoichiometric coefficient: 1.0

uniprot Q9HDX9 179
type: UnificationXref
id: Q9HDX9
db: uniprot

Glutamine--tRNA ligase
type: ProteinReference
xref: uniprot P47897 153
organism: Homo sapiens

Bifunctional glutamate/proline--tRNA ligase
type: ProteinReference
xref: uniprot P28668 151
organism: Drosophila melanogaster

uniprot Q12887 271
type: UnificationXref
id: Q12887
db: uniprot

PARTICIPANT STOICHIOMETRY r1 321
type: Stoichiometry
physical entity: tRNAglu
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 322
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot Q23315 157
type: UnificationXref
id: Q23315
db: uniprot

uniprot O44413 138
type: UnificationXref
id: O44413
db: uniprot

Porphobilinogen deaminase 2
type: ProteinReference
xref: uniprot Q9KY00 306
organism: Streptomyces coelicolor

PARTICIPANT STOICHIOMETRY r1 323
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 324
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

Siroheme synthase
type: ProteinReference
xref: uniprot Q7SI49 80
organism: Neurospora crassa

uniprot Q9LR75 237
type: UnificationXref
id: Q9LR75
db: uniprot

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r1 320
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

Glutamine--tRNA ligase
type: ProteinReference
xref: uniprot P13188 148
organism: Saccharomyces cerevisiae

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot Q28J36 106
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r13 339
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot A9U2X5 196
organism: Physcomitrella patens

uniprot P06214 203
type: UnificationXref
id: P06214
db: uniprot

PARTICIPANT STOICHIOMETRY r13 338
type: Stoichiometry
physical entity: 2 O2
stoichiometric coefficient: 1.0

Protoporphyrinogen oxidase
type: ProteinReference
xref: uniprot A0A2I3SYH2 117
organism: Pan troglodytes

uniprot Q55778 159
type: UnificationXref
id: Q55778
db: uniprot

uniprot Q9HMZ1 223
type: UnificationXref
id: Q9HMZ1
db: uniprot

SAM
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Protoheme IX farnesyltransferase
type: ProteinReference
xref: uniprot P0AEA5 267
organism: Escherichia coli

uniprot Q9VV59 187
type: UnificationXref
id: Q9VV59
db: uniprot

uniprot O34744 71
type: UnificationXref
id: O34744
db: uniprot

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 11

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot P78974 211
organism: Schizosaccharomyces pombe

uniprot P56926 155
type: UnificationXref
id: P56926
db: uniprot

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 35

PARTICIPANT STOICHIOMETRY r13 342
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Porphobilinogen deaminase
type: ProteinReference
xref: uniprot P19356 293
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r13 343
type: Stoichiometry
physical entity: protoporphyrinogen
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 344
type: Stoichiometry
physical entity: 2 H2O2
stoichiometric coefficient: 1.0

uniprot P22907 294
type: UnificationXref
id: P22907
db: uniprot

STATE_TRANSITION_LEFT__glutamyl_tRNAglu-_NADPH-RIGHT__NADP-_glutamate_1_semialdehyde-_tRNAglu-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 317
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 316
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 318
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 319
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 315
left: NADPH
left: glutamyl-tRNAglu
interaction type: STATE_TRANSITION
right: tRNAglu
right: NADP
right: glutamate-1-semialdehyde

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot F1PZA0 198
organism: Canis lupus familiaris

uniprot H2QCB0 262
type: UnificationXref
id: H2QCB0
db: uniprot

PARTICIPANT STOICHIOMETRY r13 340
type: Stoichiometry
physical entity: coproporphyrinogen III
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 341
type: Stoichiometry
physical entity: 2 CO2
stoichiometric coefficient: 1.0

uniprot P21592 268
type: UnificationXref
id: P21592
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Fe2_PLUS_-_protoporphyrin_IX-RIGHT__protoheme-_2_H_PLUS_-_r15
controller: Ferrochelatase

Glutamate-tRNA ligase
type: ProteinReference
xref: uniprot Q869Z3 167
organism: Dictyostelium discoideum

Protoheme IX farnesyltransferase, mitochondrial
type: ProteinReference
xref: uniprot F7FTL6 261
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r15 330
type: Stoichiometry
physical entity: Fe2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r15 331
type: Stoichiometry
physical entity: protoporphyrin IX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r15 332
type: Stoichiometry
physical entity: protoheme
stoichiometric coefficient: 1.0

Glutamate-1-semialdehyde 2,1-aminomutase
type: ProteinReference
xref: uniprot Q8ZYW1 257
organism: Pyrobaculum aerophilum

Oxygen-independent coproporphyrinogen-III oxidase-like protein
type: ProteinReference
xref: uniprot Q8R695 22
organism: Fusobacterium nucleatum

ncbitaxon 44689 168
type: UnificationXref
id: 44689
db: ncbitaxon

Glutaminyl-tRNA synthetase
type: ProteinReference
xref: uniprot A0A1D5QUA8 127
organism: Macaca mulatta

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot Q8ZYW5 221
organism: Pyrobaculum aerophilum

Probable porphobilinogen deaminase
type: ProteinReference
xref: uniprot Q8ZYW7 304
organism: Pyrobaculum aerophilum

uniprot F6SL08 40
type: UnificationXref
id: F6SL08
db: uniprot

Oxygen-dependent coproporphyrinogen-III oxidase
type: ProteinReference
xref: uniprot P36553 232
organism: Escherichia coli

uniprot O59786 47
type: UnificationXref
id: O59786
db: uniprot

Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
type: ProteinReference
xref: uniprot P36552 231
organism: Mus musculus

Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
type: ProteinReference
xref: uniprot P36551 230
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r15 333
type: Stoichiometry
physical entity: 2 H+
stoichiometric coefficient: 1.0

uniprot Q8EYL3 125
type: UnificationXref
id: Q8EYL3
db: uniprot

Hydroxymethylbilane synthase
type: ProteinReference
xref: uniprot E2RTD6 285
organism: Canis lupus familiaris

uniprot P06132 101
type: UnificationXref
id: P06132
db: uniprot

uniprot O62431 140
type: UnificationXref
id: O62431
db: uniprot

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot Q60178 215
organism: Methanocaldococcus jannaschii

Glutamate--tRNA ligase 2
type: ProteinReference
xref: uniprot Q9X2I8 189
organism: Thermotoga maritima

AGAP002570-PA
type: ProteinReference
xref: uniprot Q7QCD2 166
organism: Anopheles gambiae

Cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
type: ProteinReference
xref: uniprot H2QCB0 262
organism: Pan troglodytes

Heme biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__FDP-_protoheme-RIGHT__PPi-_Heme-_r16
pathway component: STATE_TRANSITION_LEFT__dihydrosirohydrochlorin-_NAD-RIGHT__NADH-_sirohydrochlorin-_r8
pathway component: STATE_TRANSITION_LEFT__H2O-_porphobilinogen-RIGHT__NH3-_hydroxymethylbilane-_r10
pathway component: STATE_TRANSITION_LEFT__hydroxymethylbilane-RIGHT__H2O-_uroporphyrinogen_III-_r6
pathway component: STATE_TRANSITION_LEFT__glutamate_1_semialdehyde-RIGHT__5_amino_levulinate-_r3
pathway component: STATE_TRANSITION_LEFT__glutamyl_tRNAglu-_NADPH-RIGHT__NADP-_glutamate_1_semialdehyde-_tRNAglu-_r2
pathway component: STATE_TRANSITION_LEFT__uroporphyrinogen_III-RIGHT__coproporphyrinogen_III-_4__CO2-_r11
pathway component: STATE_TRANSITION_LEFT__5_amino_levulinate-RIGHT__H2O-_porphobilinogen-_r4
pathway component: STATE_TRANSITION_LEFT__SAM-_uroporphyrinogen_III-RIGHT__SA_homocysteine-_dihydrosirohydrochlorin-_r7
pathway component: STATE_TRANSITION_LEFT__O2-_protoporphyrinogen-RIGHT__protoporphyrin_IX-_2_H2O-_r14
pathway component: STATE_TRANSITION_LEFT__2__O2-_NADPH-_coproporphyrinogen_III-RIGHT__2__CO2-_NADP-_protoporphyrinogen-_2__H2O2-_r13
pathway component: STATE_TRANSITION_LEFT__glutamate-_tRNAglu-_ATP-RIGHT__AMP-_PPi-_glutamyl_tRNAglu-_r1
pathway component: STATE_TRANSITION_LEFT__Fe2_PLUS_-_protoporphyrin_IX-RIGHT__protoheme-_2_H_PLUS_-_r15
pathway component: STATE_TRANSITION_LEFT__Fe2_PLUS_-_sirohydrochlorin-RIGHT__2__H_PLUS_-_siroheme-_r9
pathway component: STATE_TRANSITION_LEFT__coproporphyrinogen_III-RIGHT__protoporphyrinogen-_r12
xref: PANTHER Pathway P02746 1
comment: MODEL_NOTES=The biosynthesis of heme, a Fe+2 containing cofactor critical for the binding and transport of oxygen. Website=www.biocyc.org/Ecoli/Pathways/ free text=Biochemistry (text) Voet and Voet

uniprot F7HR87 95
type: UnificationXref
id: F7HR87
db: uniprot

Porphobilinogen deaminase
type: ProteinReference
xref: uniprot Q60169 301
organism: Pseudomonas aeruginosa

Glutamate-1-semialdehyde aminotransferase
type: Protein
entity reference: Glutamate-1-semialdehyde aminotransferase
comment: SPECIES_TYPE=PROTEIN

uniprot P73660 296
type: UnificationXref
id: P73660
db: uniprot

Glutaminyl-tRNA synthetase
type: ProteinReference
xref: uniprot E2QRQ8 131
organism: Canis lupus familiaris

Ferrochelatase-2, chloroplastic
type: ProteinReference
xref: uniprot Q0DIV0 62
organism: Oryza sativa

uniprot Q9V3D2 240
type: UnificationXref
id: Q9V3D2
db: uniprot

ncbitaxon 8364 41
type: UnificationXref
id: 8364
db: ncbitaxon

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 85

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 33

uniprot Q9RSG4 224
type: UnificationXref
id: Q9RSG4
db: uniprot

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 161

uniprot A8J7H3 241
type: UnificationXref
id: A8J7H3
db: uniprot

Glutamine--tRNA ligase, cytoplasmic
type: ProteinReference
xref: uniprot Q8W4F3 174
organism: Arabidopsis thaliana

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 25

Porphobilinogen deaminase
type: ProteinReference
xref: uniprot Q9RRY0 307
organism: Deinococcus radiodurans

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot Q7QGX8 216
organism: Anopheles gambiae

Probable glutamate--tRNA ligase, cytoplasmic
type: ProteinReference
xref: uniprot O13775 137
organism: Schizosaccharomyces pombe

siroheme
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A9U2X5 196
type: UnificationXref
id: A9U2X5
db: uniprot

uniprot Q5JPH6 162
type: UnificationXref
id: Q5JPH6
db: uniprot

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 19

Glutamate--tRNA ligase, chloroplastic/mitochondrial
type: ProteinReference
xref: uniprot Q9FEA2 178
organism: Arabidopsis thaliana

Uroporphyrinogen III synthase/methyltransferase
type: ProteinReference
xref: uniprot Q7NL92 79
organism: Gloeobacter violaceus

Danio rerio
type: BioSource
xref: ncbitaxon 7955 39

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 13

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot Q8IL68 217
organism: Plasmodium falciparum

uniprot E2RCH3 93
type: UnificationXref
id: E2RCH3
db: uniprot

Glutamine--tRNA ligase
type: ProteinReference
xref: uniprot Q9I2U8 183
organism: Pseudomonas aeruginosa

uniprot P43898 233
type: UnificationXref
id: P43898
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__2__O2-_NADPH-_coproporphyrinogen_III-RIGHT__2__CO2-_NADP-_protoporphyrinogen-_2__H2O2-_r13
controller: Coproporphyrinogen oxidase (oxygen independent)

Ferrochelatase, mitochondrial
type: ProteinReference
xref: uniprot P22315 53
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r6 366
type: Stoichiometry
physical entity: hydroxymethylbilane
stoichiometric coefficient: 1.0

uniprot P54304 14
type: UnificationXref
id: P54304
db: uniprot

PARTICIPANT STOICHIOMETRY r6 367
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

uniprot P07814 147
type: UnificationXref
id: P07814
db: uniprot

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot B0BN55 91
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r6 368
type: Stoichiometry
physical entity: uroporphyrinogen-III
stoichiometric coefficient: 1.0

Ferrochelatase
type: ProteinReference
xref: uniprot F1R362 38
organism: Danio rerio

uniprot Q9RDD2 30
type: UnificationXref
id: Q9RDD2
db: uniprot

uniprot Q9W0G4 308
type: UnificationXref
id: Q9W0G4
db: uniprot

uniprot Q9RR78 281
type: UnificationXref
id: Q9RR78
db: uniprot

uniprot Q8RDZ8 171
type: UnificationXref
id: Q8RDZ8
db: uniprot

uniprot P54919 209
type: UnificationXref
id: P54919
db: uniprot

Glutamyl-prolyl-tRNA synthetase
type: ProteinReference
xref: uniprot A0A0G2JZI2 126
organism: Rattus norvegicus

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot P05373 202
organism: Saccharomyces cerevisiae

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot P06214 203
organism: Rattus norvegicus

ncbitaxon 367110 81
type: UnificationXref
id: 367110
db: ncbitaxon

tRNAglu
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Putative uroporphyrin-III methyltransferase
type: ProteinReference
xref: uniprot Q9L1C9 89
organism: Streptomyces coelicolor

ncbitaxon 7227 70
type: UnificationXref
id: 7227
db: ncbitaxon

dihydrosirohydrochlorin
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Porphobilinogen deaminase 1
type: ProteinReference
xref: uniprot Q9WX16 309
organism: Streptomyces coelicolor

2 H+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic
type: ProteinReference
xref: uniprot Q6YZE2 254
organism: Oryza sativa

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot Q8EY41 111
organism: Leptospira interrogans

Glutamyl(E) Amino-acyl tRNA Synthetase
type: ProteinReference
xref: uniprot O44413 138
organism: Caenorhabditis elegans

Protoheme IX farnesyltransferase 2
type: ProteinReference
xref: uniprot P24009 269
organism: Bacillus subtilis

uniprot E1BEX4 92
type: UnificationXref
id: E1BEX4
db: uniprot

PANTHER Pathway P02746 1
type: UnificationXref
id: P02746
db: PANTHER Pathway

STATE_TRANSITION_LEFT__Fe2_PLUS_-_sirohydrochlorin-RIGHT__2__H_PLUS_-_siroheme-_r9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 354
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 357
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 355
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 356
left: sirohydrochlorin
left: Fe2+
interaction type: STATE_TRANSITION
right: siroheme
right: 2 H+

STATE_TRANSITION_LEFT__FDP-_protoheme-RIGHT__PPi-_Heme-_r16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 327
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 329
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 328
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 326
left: FDP
left: protoheme
interaction type: STATE_TRANSITION
right: Heme
right: PPi

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot Q9VTV9 226
organism: Drosophila melanogaster

Hydroxymethylbilane synthase
type: Protein
entity reference: Hydroxymethylbilane synthase
comment: SPECIES_TYPE=PROTEIN

uniprot P77969 210
type: UnificationXref
id: P77969
db: uniprot

Hydroxymethylbilane synthase
type: ProteinReference
xref: P02983
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Hydroxymethylbilane synthase Synonym: Synonym not specified Accession: P02983
comment: ENTITY_REFERENCE_ID_DESC=Heme biosynthesis.PROTEIN.GENERIC.Hydroxymethylbilane_br_synthase
member entity reference: Porphobilinogen deaminase 2
member entity reference: Probable porphobilinogen deaminase
member entity reference: Porphobilinogen deaminase
member entity reference: Porphobilinogen deaminase 1
member entity reference: Hydroxymethylbilane synthase
member entity reference: Porphobilinogen deaminase isoform 1
member entity reference: FI03834p

uniprot Q7Q0M3 165
type: UnificationXref
id: Q7Q0M3
db: uniprot

uniprot P45622 208
type: UnificationXref
id: P45622
db: uniprot

uniprot Q9RV96 114
type: UnificationXref
id: Q9RV96
db: uniprot

uniprot F7E161 134
type: UnificationXref
id: F7E161
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 37

Protoheme IX farnesyltransferase, mitochondrial
type: ProteinReference
xref: uniprot Q9VKZ1 282
organism: Drosophila melanogaster

uniprot Q9VTV9 226
type: UnificationXref
id: Q9VTV9
db: uniprot

uniprot A0A2I3RGL3 128
type: UnificationXref
id: A0A2I3RGL3
db: uniprot

Glutamate--tRNA ligase
type: ProteinReference
xref: uniprot O86528 144
organism: Streptomyces coelicolor

Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic
type: ProteinReference
xref: uniprot P42799 247
organism: Arabidopsis thaliana

Glutamate-1-semialdehyde 2,1-aminomutase
type: ProteinReference
xref: uniprot P23893 245
organism: Escherichia coli

uniprot M0RAI4 136
type: UnificationXref
id: M0RAI4
db: uniprot

Uncharacterized aminotransferase C417.11c
type: ProteinReference
xref: uniprot O94492 244
organism: Schizosaccharomyces pombe

uniprot O84451 143
type: UnificationXref
id: O84451
db: uniprot

uniprot P36551 230
type: UnificationXref
id: P36551
db: uniprot

uniprot Q8EY41 111
type: UnificationXref
id: Q8EY41
db: uniprot

uniprot Q9HRJ8 277
type: UnificationXref
id: Q9HRJ8
db: uniprot

uniprot P36552 231
type: UnificationXref
id: P36552
db: uniprot

uniprot P22250 149
type: UnificationXref
id: P22250
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__dihydrosirohydrochlorin-_NAD-RIGHT__NADH-_sirohydrochlorin-_r8
controller: Dimethylporphyrinogen dehydrogenase

Heme chaperone HemW
type: ProteinReference
xref: uniprot P54304 14
organism: Bacillus subtilis

uniprot P71084 249
type: UnificationXref
id: P71084
db: uniprot

uniprot P52062 12
type: UnificationXref
id: P52062
db: uniprot

uniprot P78974 211
type: UnificationXref
id: P78974
db: uniprot

Oxygen-dependent coproporphyrinogen-III oxidase
type: ProteinReference
xref: uniprot P72848 234
organism: Synechocystis

Oxygen-independent coproporphyrinogen-III oxidase-like protein
type: ProteinReference
xref: uniprot O84055 10
organism: Chlamydia trachomatis

ncbitaxon 237561 290
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot Q9I2U8 183
type: UnificationXref
id: Q9I2U8
db: uniprot

Glutamyl-tRNA synthetase 2, mitochondrial
type: ProteinReference
xref: uniprot M0RAI4 136
organism: Rattus norvegicus

Uroporphyrinogen decarboxylase 1, chloroplastic
type: ProteinReference
xref: uniprot Q93ZB6 112
organism: Arabidopsis thaliana

Glutamyl-tRNA reductase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q7UN37 110
type: UnificationXref
id: Q7UN37
db: uniprot

uniprot O84212 243
type: UnificationXref
id: O84212
db: uniprot

2 H+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

protoheme
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__O2-_protoporphyrinogen-RIGHT__protoporphyrin_IX-_2_H2O-_r14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 336
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 335
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 337
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 334
left: protoporphyrinogen
left: O2
interaction type: STATE_TRANSITION
right: protoporphyrin IX
right: 2 H2O

uniprot Q8CGC7 170
type: UnificationXref
id: Q8CGC7
db: uniprot

STATE_TRANSITION_LEFT__hydroxymethylbilane-RIGHT__H2O-_uroporphyrinogen_III-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 368
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 367
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 366
left: hydroxymethylbilane
interaction type: STATE_TRANSITION
right: uroporphyrinogen-III
right: H2O

uniprot P24009 269
type: UnificationXref
id: P24009
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__2__O2-_NADPH-_coproporphyrinogen_III-RIGHT__2__CO2-_NADP-_protoporphyrinogen-_2__H2O2-_r13
controller: Coproporphyrinogen Oxidase (oxygen dependent)

uniprot Q9V595 116
type: UnificationXref
id: Q9V595
db: uniprot

uniprot A0A3Q1MKR2 130
type: UnificationXref
id: A0A3Q1MKR2
db: uniprot

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot O84752 100
organism: Chlamydia trachomatis

ncbitaxon 1111708 17
type: UnificationXref
id: 1111708
db: ncbitaxon

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot P0ACB2 204
organism: Escherichia coli

uniprot Q8TLK3 87
type: UnificationXref
id: Q8TLK3
db: uniprot

NAD
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9X0P9 34
type: UnificationXref
id: Q9X0P9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__glutamyl_tRNAglu-_NADPH-RIGHT__NADP-_glutamate_1_semialdehyde-_tRNAglu-_r2
controller: Glutamyl-tRNA reductase

O2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Protoporphyrinogen oxidase
type: ProteinReference
xref: uniprot P50336 122
organism: Homo sapiens

STATE_TRANSITION_LEFT__dihydrosirohydrochlorin-_NAD-RIGHT__NADH-_sirohydrochlorin-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 358
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 360
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 361
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 359
left: NAD
left: dihydrosirohydrochlorin
interaction type: STATE_TRANSITION
right: sirohydrochlorin
right: NADH

uniprot P9WNE3 61
type: UnificationXref
id: P9WNE3
db: uniprot

Delta-aminolevulinic acid dehydratase 1, chloroplastic
type: ProteinReference
xref: uniprot Q9SFH9 225
organism: Arabidopsis thaliana

Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic
type: ProteinReference
xref: uniprot Q42522 251
organism: Arabidopsis thaliana

uniprot Q59643 214
type: UnificationXref
id: Q59643
db: uniprot

Ferrochelatase
type: ProteinReference
xref: uniprot Q9HVD7 67
organism: Pseudomonas aeruginosa

uniprot P48247 248
type: UnificationXref
id: P48247
db: uniprot

Uroporphyrinogen-III C-methyltransferase
type: ProteinReference
xref: uniprot P36150 74
organism: Saccharomyces cerevisiae

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot E2RCH3 93
organism: Canis lupus familiaris

protoporphyrinogen
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9CXJ1 177
type: UnificationXref
id: Q9CXJ1
db: uniprot

uniprot P32396 59
type: UnificationXref
id: P32396
db: uniprot

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 78

uniprot O66998 242
type: UnificationXref
id: O66998
db: uniprot

Ferrochelatase, mitochondrial
type: ProteinReference
xref: uniprot Q9V9S8 69
organism: Drosophila melanogaster

ncbitaxon 9598 7
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot A0A2I3SYH2 117
type: UnificationXref
id: A0A2I3SYH2
db: uniprot

Uroporphyrin-III C-methyltransferase
type: ProteinReference
xref: uniprot Q7NHF7 77
organism: Gloeobacter violaceus

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot P06132 101
organism: Homo sapiens

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot O67876 200
organism: Aquifex aeolicus

uniprot P36553 232
type: UnificationXref
id: P36553
db: uniprot

Glutamate-1-semialdehyde 2,1-aminomutase
type: ProteinReference
xref: uniprot O84212 243
organism: Chlamydia trachomatis

uniprot Q8RFP5 302
type: UnificationXref
id: Q8RFP5
db: uniprot

uniprot A0A0G2JZI2 126
type: UnificationXref
id: A0A0G2JZI2
db: uniprot

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot Q59643 214
organism: Pseudomonas aeruginosa

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot F7HR87 95
organism: Macaca mulatta

uniprot B0BN55 91
type: UnificationXref
id: B0BN55
db: uniprot

ncbitaxon 9606 27
type: UnificationXref
id: 9606
db: ncbitaxon

ncbitaxon 208964 29
type: UnificationXref
id: 208964
db: ncbitaxon

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 52

uniprot P13188 148
type: UnificationXref
id: P13188
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 70

uniprot Q94LA4 222
type: UnificationXref
id: Q94LA4
db: uniprot

Coproporphyrinogen III oxidase
type: ProteinReference
xref: uniprot Q9S7V1 238
organism: Chlamydomonas reinhardtii

Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase
type: ProteinReference
xref: uniprot Q9RZD8 90
organism: Deinococcus radiodurans

Protoheme IX farnesyltransferase, mitochondrial
type: ProteinReference
xref: uniprot Q12887 271
organism: Homo sapiens

STATE_TRANSITION_LEFT__5_amino_levulinate-RIGHT__H2O-_porphobilinogen-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 311
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 310
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 312
left: 5-amino-levulinate
interaction type: STATE_TRANSITION
right: H2O
right: porphobilinogen

uniprot P05373 202
type: UnificationXref
id: P05373
db: uniprot

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot Q8TT59 220
organism: Methanosarcina acetivorans

Glutamine--tRNA ligase
type: ProteinReference
xref: uniprot Q8BML9 169
organism: Mus musculus

Coproporphyrinogen-III oxidase 2, chloroplastic
type: ProteinReference
xref: uniprot Q93Z96 236
organism: Arabidopsis thaliana

Probable porphobilinogen deaminase
type: ProteinReference
xref: uniprot Q8TT56 303
organism: Methanosarcina acetivorans

Ferrochelatase
type: ProteinReference
xref: uniprot O67083 49
organism: Aquifex aeolicus

Glutamate-1-semialdehyde 2,1-aminomutase
type: ProteinReference
xref: uniprot Q8TT57 256
organism: Methanosarcina acetivorans

ncbitaxon 9615 94
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot O82462 142
type: UnificationXref
id: O82462
db: uniprot

ncbitaxon 9913 55
type: UnificationXref
id: 9913
db: ncbitaxon

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 218

Coproporphyrinogen III oxidase
type: ProteinReference
xref: uniprot F5H9D4 227
organism: Neurospora crassa

uniprot Q9PTS2 113
type: UnificationXref
id: Q9PTS2
db: uniprot

Probable oxygen-dependent coproporphyrinogen-III oxidase
type: ProteinReference
xref: uniprot Q9UTE2 239
organism: Schizosaccharomyces pombe

PARTICIPANT STOICHIOMETRY r12 346
type: Stoichiometry
physical entity: protoporphyrinogen
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r12 345
type: Stoichiometry
physical entity: coproporphyrinogen III
stoichiometric coefficient: 1.0

ncbitaxon 3055 195
type: UnificationXref
id: 3055
db: ncbitaxon

uniprot H2PYW8 96
type: UnificationXref
id: H2PYW8
db: uniprot

uniprot Q8IL68 217
type: UnificationXref
id: Q8IL68
db: uniprot

uniprot Q9I423 278
type: UnificationXref
id: Q9I423
db: uniprot

ncbitaxon 251221 78
type: UnificationXref
id: 251221
db: ncbitaxon

ncbitaxon 83332 19
type: UnificationXref
id: 83332
db: ncbitaxon

Ferrochelatase, mitochondrial
type: ProteinReference
xref: uniprot O59786 47
organism: Schizosaccharomyces pombe

Ferrochelatase, mitochondrial
type: ProteinReference
xref: uniprot P22830 56
organism: Homo sapiens

ncbitaxon 10090 21
type: UnificationXref
id: 10090
db: ncbitaxon

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 41

Protoheme IX farnesyl transferase
type: ProteinReference
xref: P02982
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protoheme IX farnesyl transferase Synonym: Synonym not specified Accession: P02982
comment: ENTITY_REFERENCE_ID_DESC=Heme biosynthesis.PROTEIN.GENERIC.Protoheme IX farnesyl transferase
member entity reference: Protoheme IX farnesyltransferase, mitochondrial
member entity reference: Protoheme IX farnesyltransferase
member entity reference: Cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
member entity reference: Protoheme IX farnesyltransferase 1
member entity reference: AGAP008884-PA
member entity reference: Protoheme IX farnesyltransferase 2
member entity reference: Os01g0527700 protein
member entity reference: 4-hydroxybenzoate polyprenyltransferase, mitochondrial

uniprot P51175 123
type: UnificationXref
id: P51175
db: uniprot

Glutamate-1-semialdehyde aminotransferase
type: ProteinReference
xref: uniprot A8J7H3 241
organism: Chlamydomonas reinhardtii

Glutamine--tRNA ligase
type: ProteinReference
xref: uniprot Q3MHH4 158
organism: Bos taurus

STATE_TRANSITION_LEFT__glutamate-_tRNAglu-_ATP-RIGHT__AMP-_PPi-_glutamyl_tRNAglu-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 322
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 320
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 323
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 324
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 321
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 325
left: ATP
left: tRNAglu
left: glutamate
interaction type: STATE_TRANSITION
right: AMP
right: glutamyl-tRNAglu
right: PPi

NH3
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q5VRX8 163
type: UnificationXref
id: Q5VRX8
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Fe2_PLUS_-_sirohydrochlorin-RIGHT__2__H_PLUS_-_siroheme-_r9
controller: Siroheme ferrochelatase

uniprot Q9F2S0 258
type: UnificationXref
id: Q9F2S0
db: uniprot

uniprot E2RTD6 285
type: UnificationXref
id: E2RTD6
db: uniprot

uniprot O84055 10
type: UnificationXref
id: O84055
db: uniprot

PARTICIPANT STOICHIOMETRY r7 362
type: Stoichiometry
physical entity: SAM
stoichiometric coefficient: 1.0

ncbitaxon 224324 9
type: UnificationXref
id: 224324
db: ncbitaxon

Precorrin methylase
type: ProteinReference
xref: uniprot Q7NHI9 108
organism: Gloeobacter violaceus

Glutamate--tRNA ligase, cytoplasmic
type: ProteinReference
xref: uniprot P46655 152
organism: Saccharomyces cerevisiae

ncbitaxon 6945 3
type: UnificationXref
id: 6945
db: ncbitaxon

uniprot O94492 244
type: UnificationXref
id: O94492
db: uniprot

PARTICIPANT STOICHIOMETRY r7 364
type: Stoichiometry
physical entity: SA-homocysteine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 363
type: Stoichiometry
physical entity: uroporphyrinogen-III
stoichiometric coefficient: 1.0

glutamate-1-semialdehyde
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r7 365
type: Stoichiometry
physical entity: dihydrosirohydrochlorin
stoichiometric coefficient: 1.0

uniprot P11353 229
type: UnificationXref
id: P11353
db: uniprot

uniprot P29680 102
type: UnificationXref
id: P29680
db: uniprot

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot P70697 105
organism: Mus musculus

ncbitaxon 7955 39
type: UnificationXref
id: 7955
db: ncbitaxon

Os01g0527700 protein
type: ProteinReference
xref: uniprot Q5QLH9 272
organism: Oryza sativa

Protoheme IX farnesyltransferase
type: ProteinReference
xref: uniprot Q9RM98 280
organism: Bradyrhizobium diazoefficiens

uniprot Q9X172 188
type: UnificationXref
id: Q9X172
db: uniprot

Fe2+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot D3ZBM3 36
type: UnificationXref
id: D3ZBM3
db: uniprot

uniprot O74468 73
type: UnificationXref
id: O74468
db: uniprot

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot Q7UN37 110
organism: Rhodopirellula baltica

Ferrochelatase, mitochondrial
type: ProteinReference
xref: uniprot O42479 44
organism: Gallus gallus

uniprot F6ZKY9 42
type: UnificationXref
id: F6ZKY9
db: uniprot

uniprot Q7NEK2 107
type: UnificationXref
id: Q7NEK2
db: uniprot

Glutamine--tRNA ligase
type: ProteinReference
xref: uniprot P00962 145
organism: Escherichia coli

Ferrochelatase, mitochondrial
type: ProteinReference
xref: uniprot P22600 54
organism: Bos taurus

uniprot Q7NL92 79
type: UnificationXref
id: Q7NL92
db: uniprot

uniprot Q9V9S8 69
type: UnificationXref
id: Q9V9S8
db: uniprot

ncbitaxon 190304 23
type: UnificationXref
id: 190304
db: ncbitaxon

uniprot Q8EYJ6 84
type: UnificationXref
id: Q8EYJ6
db: uniprot

uniprot P16616 292
type: UnificationXref
id: P16616
db: uniprot

Uroporphyrinogen-III C-methyltransferase
type: ProteinReference
xref: uniprot O34744 71
organism: Bacillus subtilis

uniprot O67271 141
type: UnificationXref
id: O67271
db: uniprot

uniprot P22600 54
type: UnificationXref
id: P22600
db: uniprot

Protoheme IX farnesyltransferase
type: ProteinReference
xref: uniprot O66544 266
organism: Aquifex aeolicus

Glutamate--tRNA ligase
type: ProteinReference
xref: uniprot Q9HQI1 180
organism: Halobacterium salinarum

Radical S-adenosyl methionine domain-containing protein 1, mitochondrial
type: ProteinReference
xref: uniprot Q5SUV1 20
organism: Mus musculus

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot Q7SE23 109
organism: Neurospora crassa

Glutamyl-tRNA synthetase 2, mitochondrial (Putative)
type: ProteinReference
xref: uniprot H2QAR9 135
organism: Pan troglodytes

uniprot O66544 266
type: UnificationXref
id: O66544
db: uniprot

uniprot F1R362 38
type: UnificationXref
id: F1R362
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 55

uniprot Q9SFH9 225
type: UnificationXref
id: Q9SFH9
db: uniprot

uniprot A0A2I3TUI6 129
type: UnificationXref
id: A0A2I3TUI6
db: uniprot

uniprot Q7SE23 109
type: UnificationXref
id: Q7SE23
db: uniprot

uniprot Q58DK5 213
type: UnificationXref
id: Q58DK5
db: uniprot

Glutamyl-Q tRNA(Asp) synthetase
type: ProteinReference
xref: uniprot Q9HV75 182
organism: Pseudomonas aeruginosa

uniprot Q9HQI1 180
type: UnificationXref
id: Q9HQI1
db: uniprot

uniprot Q93ZB6 112
type: UnificationXref
id: Q93ZB6
db: uniprot

uniprot P72848 234
type: UnificationXref
id: P72848
db: uniprot

uniprot P04805 146
type: UnificationXref
id: P04805
db: uniprot

uniprot Q42606 76
type: UnificationXref
id: Q42606
db: uniprot

uniprot E2QUR2 132
type: UnificationXref
id: E2QUR2
db: uniprot

4-hydroxybenzoate polyprenyltransferase, mitochondrial
type: ProteinReference
xref: uniprot Q93YP7 276
organism: Arabidopsis thaliana

ncbitaxon 3702 25
type: UnificationXref
id: 3702
db: ncbitaxon

FDP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O84492 50
type: UnificationXref
id: O84492
db: uniprot

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot P54919 209
organism: Streptomyces coelicolor

Probable glutamine--tRNA ligase
type: ProteinReference
xref: uniprot O62431 140
organism: Caenorhabditis elegans

Heme
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 3

uniprot P73245 16
type: UnificationXref
id: P73245
db: uniprot

uniprot F6R4X7 133
type: UnificationXref
id: F6R4X7
db: uniprot

Glutamate--tRNA ligase
type: ProteinReference
xref: uniprot Q8ZU33 175
organism: Pyrobaculum aerophilum

uniprot F7HBT8 4
type: UnificationXref
id: F7HBT8
db: uniprot

uniprot Q7SI49 80
type: UnificationXref
id: Q7SI49
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 94

uniprot Q9HA92 26
type: UnificationXref
id: Q9HA92
db: uniprot

Glutamate-1-semialdehyde 2,1-aminomutase
type: ProteinReference
xref: uniprot Q55665 252
organism: Synechocystis

Probable porphobilinogen deaminase
type: ProteinReference
xref: uniprot Q57989 300
organism: Methanocaldococcus jannaschii

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot P77969 210
organism: Synechocystis

uniprot Q7QGX8 216
type: UnificationXref
id: Q7QGX8
db: uniprot

uniprot Q9RRY0 307
type: UnificationXref
id: Q9RRY0
db: uniprot

Glutamate--tRNA ligase
type: ProteinReference
xref: uniprot O67271 141
organism: Aquifex aeolicus

Glutamyl-tRNA synthetase, mitochondrial
type: ProteinReference
xref: uniprot Q9VV59 187
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__H2O-_porphobilinogen-RIGHT__NH3-_hydroxymethylbilane-_r10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 351
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 353
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 352
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 350
left: H2O
left: porphobilinogen
interaction type: STATE_TRANSITION
right: hydroxymethylbilane
right: NH3

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 45

ncbitaxon 272561 11
type: UnificationXref
id: 272561
db: ncbitaxon

Uroporphyrin-III C-methyltransferase
type: ProteinReference
xref: uniprot Q8EYJ6 84
organism: Leptospira interrogans

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot H2PYW8 96
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r10 353
type: Stoichiometry
physical entity: hydroxymethylbilane
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 352
type: Stoichiometry
physical entity: NH3
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FDP-_protoheme-RIGHT__PPi-_Heme-_r16
controller: Protoheme IX farnesyl transferase

Uroporphyrin-III c-methyltransferase
type: ProteinReference
xref: uniprot O66584 72
organism: Aquifex aeolicus

PARTICIPANT STOICHIOMETRY r10 351
type: Stoichiometry
physical entity: porphobilinogen
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 350
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Porphobilinogen deaminase
type: ProteinReference
xref: uniprot Q09899 298
organism: Schizosaccharomyces pombe

Protoheme IX farnesyltransferase, mitochondrial
type: ProteinReference
xref: uniprot O64886 265
organism: Arabidopsis thaliana

uniprot P32347 103
type: UnificationXref
id: P32347
db: uniprot

hydroxymethylbilane
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Protoporphyrinogen oxidase
type: ProteinReference
xref: uniprot P51175 123
organism: Mus musculus

uniprot P27305 150
type: UnificationXref
id: P27305
db: uniprot

AMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Oxygen-independent coproporphyrinogen-III oxidase-like protein
type: ProteinReference
xref: uniprot Q9RY22 32
organism: Deinococcus radiodurans

Glutamyl-prolyl-tRNA synthetase
type: ProteinReference
xref: uniprot A0A2I3TUI6 129
organism: Pan troglodytes

Porphobilinogen deaminase
type: ProteinReference
xref: uniprot O94048 289
organism: Candida albicans

uniprot Q60178 215
type: UnificationXref
id: Q60178
db: uniprot

coproporphyrinogen III
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8BML9 169
type: UnificationXref
id: Q8BML9
db: uniprot

Glutamate--tRNA ligase
type: ProteinReference
xref: uniprot Q8TT52 173
organism: Methanosarcina acetivorans

L-amino acid oxidase
type: ProteinReference
xref: uniprot Q8EYL3 125
organism: Leptospira interrogans

Porphobilinogen deaminase
type: ProteinReference
xref: uniprot P28789 295
organism: Saccharomyces cerevisiae

uniprot Q9RY22 32
type: UnificationXref
id: Q9RY22
db: uniprot

uniprot Q9FMJ4 24
type: UnificationXref
id: Q9FMJ4
db: uniprot

uniprot Q9RV98 68
type: UnificationXref
id: Q9RV98
db: uniprot

uniprot Q7PWQ5 274
type: UnificationXref
id: Q7PWQ5
db: uniprot

ncbitaxon 243232 161
type: UnificationXref
id: 243232
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__5_amino_levulinate-RIGHT__H2O-_porphobilinogen-_r4
controller: porphobilinogen synthase

uniprot O50533 46
type: UnificationXref
id: O50533
db: uniprot

Glutamate--tRNA ligase
type: ProteinReference
xref: uniprot Q9XCL6 190
organism: Pseudomonas aeruginosa

uniprot P19356 293
type: UnificationXref
id: P19356
db: uniprot

Glutamate-1-semialdehyde 2,1-aminomutase
type: ProteinReference
xref: uniprot P48247 248
organism: Pseudomonas aeruginosa

Protoheme IX farnesyltransferase 1
type: ProteinReference
xref: uniprot Q9I719 279
organism: Pseudomonas aeruginosa

4 CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

SA-homocysteine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O66584 72
type: UnificationXref
id: O66584
db: uniprot

uniprot Q0DIV0 62
type: UnificationXref
id: Q0DIV0
db: uniprot

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot Q58DK5 213
organism: Bos taurus

uniprot O22886 97
type: UnificationXref
id: O22886
db: uniprot

Bifunctional aminoacyl-tRNA synthetase
type: ProteinReference
xref: uniprot F7E161 134
organism: Macaca mulatta

sirohydrochlorin
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P46655 152
type: UnificationXref
id: P46655
db: uniprot

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot P45622 208
organism: Bradyrhizobium diazoefficiens

uniprot Q9KY00 306
type: UnificationXref
id: Q9KY00
db: uniprot

Protoporphyrinogen oxidase
type: ProteinReference
xref: uniprot D3ZVN7 118
organism: Rattus norvegicus

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 63

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 29

uniprot B7PXP0 2
type: UnificationXref
id: B7PXP0
db: uniprot

Oxygen-dependent coproporphyrinogen-III oxidase
type: ProteinReference
xref: uniprot P43898 233
organism: Pseudomonas aeruginosa

Glutamate-1-semialdehyde 2,1-aminomutase
type: ProteinReference
xref: uniprot O66998 242
organism: Aquifex aeolicus

Glutamate-1-semialdehyde 2,1-aminomutase
type: ProteinReference
xref: uniprot Q9F2S0 258
organism: Streptomyces coelicolor

Glutamine--tRNA ligase
type: ProteinReference
xref: uniprot P56926 155
organism: Deinococcus radiodurans

ncbitaxon 10116 37
type: UnificationXref
id: 10116
db: ncbitaxon

NADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P30950 207
type: UnificationXref
id: P30950
db: uniprot

uniprot F5H9D4 227
type: UnificationXref
id: F5H9D4
db: uniprot

Glutamyl-Q tRNA(Asp) synthetase
type: ProteinReference
xref: uniprot Q9RTR9 185
organism: Deinococcus radiodurans

porphobilinogen
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 181

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__O2-_protoporphyrinogen-RIGHT__protoporphyrin_IX-_2_H2O-_r14
controller: Protoporphyrinogen oxidase

Dimethylporphyrinogen dehydrogenase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Ferrochelatase
type: ProteinReference
xref: uniprot P54225 60
organism: Synechocystis

PPi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot P32347 103
organism: Saccharomyces cerevisiae

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 66

uniprot Q9L1C9 89
type: UnificationXref
id: Q9L1C9
db: uniprot

porphobilinogen synthase
type: ProteinReference
xref: P02979
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Heme biosynthesis.PROTEIN.GENERIC.porphobilinogen_br_synthase
comment: ENTITY_REFERENCE_NOTES=Long Name: porphobilinogen synthase Synonym: Synonym not specified Accession: P02979
member entity reference: Delta-aminolevulinic acid dehydratase
member entity reference: Probable delta-aminolevulinic acid dehydratase 2, chloroplastic
member entity reference: Delta-aminolevulinic acid dehydratase 1, chloroplastic

uniprot Q9USJ5 115
type: UnificationXref
id: Q9USJ5
db: uniprot

ncbitaxon 559292 52
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot Q9Y105 191
type: UnificationXref
id: Q9Y105
db: uniprot

uniprot Q8W4F3 174
type: UnificationXref
id: Q8W4F3
db: uniprot

Bifunctional glutamate/proline--tRNA ligase
type: ProteinReference
xref: uniprot Q8CGC7 170
organism: Mus musculus

uniprot Q9RTR9 185
type: UnificationXref
id: Q9RTR9
db: uniprot

uniprot E2QRQ8 131
type: UnificationXref
id: E2QRQ8
db: uniprot

uniprot P32395 104
type: UnificationXref
id: P32395
db: uniprot

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 17

uniprot Q57989 300
type: UnificationXref
id: Q57989
db: uniprot

uniprot P56602 124
type: UnificationXref
id: P56602
db: uniprot

uniprot Q9WX16 309
type: UnificationXref
id: Q9WX16
db: uniprot

PARTICIPANT STOICHIOMETRY r14 334
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

Probable glutamate--tRNA ligase, mitochondrial
type: ProteinReference
xref: uniprot Q5JPH6 162
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r14 335
type: Stoichiometry
physical entity: protoporphyrinogen
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 336
type: Stoichiometry
physical entity: protoporphyrin IX
stoichiometric coefficient: 1.0

ncbitaxon 243230 33
type: UnificationXref
id: 243230
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r14 337
type: Stoichiometry
physical entity: 2 H2O
stoichiometric coefficient: 1.0

Oxygen-dependent coproporphyrinogen-III oxidase
type: ProteinReference
xref: uniprot Q9V3D2 240
organism: Drosophila melanogaster

Ferrochelatase
type: ProteinReference
xref: uniprot Q7QG25 65
organism: Anopheles gambiae

uniprot Q9Y7Y8 192
type: UnificationXref
id: Q9Y7Y8
db: uniprot

Protoheme IX farnesyltransferase
type: ProteinReference
xref: uniprot P9WFR7 270
organism: Mycobacterium tuberculosis

uniprot O67083 49
type: UnificationXref
id: O67083
db: uniprot

Ferrochelatase
type: ProteinReference
xref: uniprot F6SL08 40
organism: Xenopus tropicalis

Bifunctional glutamate/proline--tRNA ligase
type: ProteinReference
xref: uniprot P07814 147
organism: Homo sapiens

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uroporphyrin-III C-methyltransferase
type: ProteinReference
xref: uniprot Q8TLK3 87
organism: Methanosarcina acetivorans

uniprot Q8TT56 303
type: UnificationXref
id: Q8TT56
db: uniprot

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot P32395 104
organism: Bacillus subtilis

Protoporphyrinogen oxidase
type: ProteinReference
xref: uniprot P32397 121
organism: Bacillus subtilis

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 48

Ferrochelatase
type: ProteinReference
xref: uniprot P32396 59
organism: Bacillus subtilis

uniprot Q8CFY5 275
type: UnificationXref
id: Q8CFY5
db: uniprot

Radical S-adenosyl methionine domain-containing protein
type: ProteinReference
xref: uniprot H2QDF3 6
organism: Pan troglodytes

uniprot O42479 44
type: UnificationXref
id: O42479
db: uniprot

uniprot P13716 206
type: UnificationXref
id: P13716
db: uniprot

Glutamyl-tRNA synthetase family protein, expressed
type: ProteinReference
xref: uniprot Q8S5M6 172
organism: Oryza sativa

uniprot P0ACB2 204
type: UnificationXref
id: P0ACB2
db: uniprot

uniprot P23893 245
type: UnificationXref
id: P23893
db: uniprot

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot Q8RG58 219
organism: Fusobacterium nucleatum

uniprot P9WMP3 297
type: UnificationXref
id: P9WMP3
db: uniprot

Uroporphyrinogen methyltransferase
type: Protein
entity reference: Uroporphyrinogen methyltransferase
comment: SPECIES_TYPE=PROTEIN

Protoheme IX farnesyltransferase
type: ProteinReference
xref: uniprot Q9RR78 281
organism: Deinococcus radiodurans

ncbitaxon 9544 5
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot F7GY51 199
type: UnificationXref
id: F7GY51
db: uniprot

uniprot Q3B7D0 235
type: UnificationXref
id: Q3B7D0
db: uniprot

Glutaminyl-tRNA synthetase
type: ProteinReference
xref: uniprot A0A2I3RGL3 128
organism: Pan troglodytes

Ferrochelatase
type: Protein
entity reference: Ferrochelatase
comment: SPECIES_TYPE=PROTEIN

uniprot Q3MHH4 158
type: UnificationXref
id: Q3MHH4
db: uniprot

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot E1BEX4 92
organism: Bos taurus

Coproporphyrinogen oxidase (oxygen independent)
type: ProteinReference
xref: P02970
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Coproporphyrinogen oxidase (oxygen independent) Synonym: Synonym not specified Accession: P02970
comment: ENTITY_REFERENCE_ID_DESC=Heme biosynthesis.PROTEIN.GENERIC.Coproporphyrinogen oxidase_br_(oxygen independent)
member entity reference: Oxygen-independent coproporphyrinogen-III oxidase-like protein
member entity reference: Heme chaperone HemW
member entity reference: At5g63290
member entity reference: Radical S-adenosyl methionine domain-containing protein
member entity reference: Coproporphyrinigen III oxidase, putative (Fragment)
member entity reference: Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

Heme chaperone HemW
type: ProteinReference
xref: uniprot P73245 16
organism: Synechocystis

ncbitaxon 224308 15
type: UnificationXref
id: 224308
db: ncbitaxon

uniprot Q9HMY8 259
type: UnificationXref
id: Q9HMY8
db: uniprot

AGAP008884-PA
type: ProteinReference
xref: uniprot Q7PWQ5 274
organism: Anopheles gambiae

uniprot P48525 154
type: UnificationXref
id: P48525
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 27

uniprot E2RG94 119
type: UnificationXref
id: E2RG94
db: uniprot

Coproporphyrinogen oxidase (oxygen independent)
type: Protein
entity reference: Coproporphyrinogen oxidase (oxygen independent)
comment: SPECIES_TYPE=PROTEIN

Heme chaperone HemW
type: ProteinReference
xref: uniprot P52062 12
organism: Escherichia coli

uniprot Q9FEA2 178
type: UnificationXref
id: Q9FEA2
db: uniprot

STATE_TRANSITION_LEFT__glutamate_1_semialdehyde-RIGHT__5_amino_levulinate-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 313
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 314
left: glutamate-1-semialdehyde
interaction type: STATE_TRANSITION
right: 5-amino-levulinate

uniprot P28789 295
type: UnificationXref
id: P28789
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__glutamate-_tRNAglu-_ATP-RIGHT__AMP-_PPi-_glutamyl_tRNAglu-_r1
controller: Glutamyl-tRNA-synthetase

Probable glutamate--tRNA ligase, mitochondrial
type: ProteinReference
xref: uniprot Q9CXJ1 177
organism: Mus musculus

Ferrochelatase
type: ProteinReference
xref: uniprot P28602 57
organism: Bradyrhizobium diazoefficiens

uniprot O94048 289
type: UnificationXref
id: O94048
db: uniprot

uniprot Q9HV75 182
type: UnificationXref
id: Q9HV75
db: uniprot

Oxygen-independent coproporphyrinogen-III oxidase-like protein
type: ProteinReference
xref: uniprot Q9RDD2 30
organism: Streptomyces coelicolor

uniprot Q58020 253
type: UnificationXref
id: Q58020
db: uniprot

ncbitaxon 100226 31
type: UnificationXref
id: 100226
db: ncbitaxon

uniprot D3ZVN7 118
type: UnificationXref
id: D3ZVN7
db: uniprot

protoporphyrin IX
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P9WP73 18
type: UnificationXref
id: P9WP73
db: uniprot

Uroporphyrinogen methyltransferase
type: ProteinReference
xref: P02973
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Uroporphyrinogen methyltransferase Synonym: Synonym not specified Accession: P02973
comment: ENTITY_REFERENCE_ID_DESC=Heme biosynthesis.PROTEIN.GENERIC.Uroporphyrinogen_br_methyltransferase
member entity reference: Uroporphyrinogen III synthase/methyltransferase
member entity reference: Uroporphyrinogen-III C-methyltransferase
member entity reference: AT5g40850/MHK7_8
member entity reference: Uroporphyrin-III c-methyltransferase
member entity reference: Probable uroporphyrinogen-III C-methyltransferase
member entity reference: Uroporphyrin-III C-methyltransferase
member entity reference: Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase
member entity reference: Siroheme synthase
member entity reference: Putative uroporphyrin-III methyltransferase

Glutamate-1-semialdehyde 2,1-aminomutase
type: ProteinReference
xref: uniprot Q8RFY7 255
organism: Fusobacterium nucleatum

uniprot P50336 122
type: UnificationXref
id: P50336
db: uniprot

Uroporphyrin-III C-methyltransferase
type: ProteinReference
xref: uniprot Q8RFP6 86
organism: Fusobacterium nucleatum

AT5g40850/MHK7_8
type: ProteinReference
xref: uniprot Q42606 76
organism: Arabidopsis thaliana

Porphobilinogen deaminase
type: ProteinReference
xref: uniprot Q8RFP5 302
organism: Fusobacterium nucleatum

uniprot Q7NHF7 77
type: UnificationXref
id: Q7NHF7
db: uniprot

2 CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O84301 288
type: UnificationXref
id: O84301
db: uniprot

uniprot Q28J36 106
type: UnificationXref
id: Q28J36
db: uniprot

uniprot H2QAR9 135
type: UnificationXref
id: H2QAR9
db: uniprot

Oxygen-independent coproporphyrinogen-III oxidase-like protein
type: ProteinReference
xref: uniprot O67418 8
organism: Aquifex aeolicus

Protoheme IX farnesyltransferase 1
type: ProteinReference
xref: uniprot O31652 264
organism: Bacillus subtilis

Siroheme ferrochelatase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q5QLH9 272
type: UnificationXref
id: Q5QLH9
db: uniprot

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 23

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 168

At5g63290
type: ProteinReference
xref: uniprot Q9FMJ4 24
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r3 313
type: Stoichiometry
physical entity: glutamate-1-semialdehyde
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 314
type: Stoichiometry
physical entity: 5-amino-levulinate
stoichiometric coefficient: 1.0

Glutamate--tRNA ligase 1
type: ProteinReference
xref: uniprot Q9X172 188
organism: Thermotoga maritima

STATE_TRANSITION_LEFT__Fe2_PLUS_-_protoporphyrin_IX-RIGHT__protoheme-_2_H_PLUS_-_r15
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 330
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 333
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 332
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 331
left: protoporphyrin IX
left: Fe2+
interaction type: STATE_TRANSITION
right: 2 H+
right: protoheme

uniprot A0A1D5QUA8 127
type: UnificationXref
id: A0A1D5QUA8
db: uniprot

uniprot O67418 8
type: UnificationXref
id: O67418
db: uniprot

uniprot P70697 105
type: UnificationXref
id: P70697
db: uniprot

Ferrochelatase
type: ProteinReference
xref: P02972
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Heme biosynthesis.PROTEIN.GENERIC.Ferrochelatase
comment: ENTITY_REFERENCE_NOTES=Long Name: Ferrochelatase Synonym: Synonym not specified Accession: P02972
member entity reference: Ferrochelatase, mitochondrial
member entity reference: Ferrochelatase-2, chloroplastic
member entity reference: Ferrochelatase
member entity reference: Probable ferrochelatase

Glutamyl-tRNA-synthetase
type: ProteinReference
xref: P02977
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Heme biosynthesis.PROTEIN.GENERIC.Glutamyl-tRNA-_br_synthetase
comment: ENTITY_REFERENCE_NOTES=Long Name: Glutamyl-tRNA-synthetase Synonym: Synonym not specified Accession: P02977
member entity reference: Glutamyl(E) Amino-acyl tRNA Synthetase
member entity reference: Glutamine--tRNA ligase
member entity reference: Glutamate--tRNA ligase
member entity reference: Probable glutamine--tRNA ligase
member entity reference: Os01g0185200 protein
member entity reference: Glutaminyl-tRNA synthetase
member entity reference: Glutamate--tRNA ligase, cytoplasmic
member entity reference: Glutamate--tRNA ligase, chloroplastic/mitochondrial
member entity reference: Probable glutamate--tRNA ligase, cytoplasmic
member entity reference: Glutamyl-prolyl-tRNA synthetase
member entity reference: Bifunctional glutamate/proline--tRNA ligase
member entity reference: Glutamyl-tRNA synthetase, mitochondrial
member entity reference: Glutamyl-tRNA synthetase family protein, expressed
member entity reference: Uncharacterized protein
member entity reference: Glutamyl-Q tRNA(Asp) synthetase
member entity reference: Glutamate--tRNA ligase, mitochondrial
member entity reference: AGAP010267-PA
member entity reference: Os01g0271200 protein
member entity reference: Glutamate--tRNA ligase 1
member entity reference: Glutamate-tRNA ligase
member entity reference: Glutamyl-tRNA synthetase 2, mitochondrial
member entity reference: Bifunctional aminoacyl-tRNA synthetase
member entity reference: AGAP002945-PA
member entity reference: Glutamate--tRNA ligase 2
member entity reference: Glutamyl-tRNA synthetase 2, mitochondrial (Putative)
member entity reference: Glutamine--tRNA ligase, cytoplasmic
member entity reference: AGAP002570-PA
member entity reference: Probable glutamate--tRNA ligase, mitochondrial

uniprot Q8TT59 220
type: UnificationXref
id: Q8TT59
db: uniprot

glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Glutamate--tRNA ligase, mitochondrial
type: ProteinReference
xref: uniprot P48525 154
organism: Saccharomyces cerevisiae

ncbitaxon 36329 218
type: UnificationXref
id: 36329
db: ncbitaxon

Porphobilinogen deaminase
type: ProteinReference
xref: uniprot P73660 296
organism: Synechocystis

Coproporphyrinogen-III oxidase 1, chloroplastic
type: ProteinReference
xref: uniprot Q9LR75 237
organism: Arabidopsis thaliana

uniprot Q9S7V1 238
type: UnificationXref
id: Q9S7V1
db: uniprot

Probable ferrochelatase
type: ProteinReference
xref: uniprot O50533 46
organism: Streptomyces coelicolor

uniprot Q55665 252
type: UnificationXref
id: Q55665
db: uniprot

2 O2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Probable delta-aminolevulinic acid dehydratase 2, chloroplastic
type: ProteinReference
xref: uniprot Q94LA4 222
organism: Arabidopsis thaliana

uniprot O67876 200
type: UnificationXref
id: O67876
db: uniprot

Protoporphyrinogen oxidase
type: ProteinReference
xref: uniprot E2RG94 119
organism: Canis lupus familiaris

Ferrochelatase
type: ProteinReference
xref: uniprot D3ZBM3 36
organism: Rattus norvegicus

Glutamyl-prolyl-tRNA synthetase
type: ProteinReference
xref: uniprot E2QUR2 132
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__glutamate_1_semialdehyde-RIGHT__5_amino_levulinate-_r3
controller: Glutamate-1-semialdehyde aminotransferase

Ferrochelatase
type: ProteinReference
xref: uniprot P9WNE3 61
organism: Mycobacterium tuberculosis

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MKR2 130
organism: Bos taurus

ncbitaxon 224911 58
type: UnificationXref
id: 224911
db: ncbitaxon

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 83

uniprot Q79EF2 273
type: UnificationXref
id: Q79EF2
db: uniprot

Oxygen-independent coproporphyrinogen-III oxidase-like protein
type: ProteinReference
xref: uniprot Q9I6A9 28
organism: Pseudomonas aeruginosa

2 H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O84752 100
type: UnificationXref
id: O84752
db: uniprot

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot O84638 201
organism: Chlamydia trachomatis

uniprot Q9UTE2 239
type: UnificationXref
id: Q9UTE2
db: uniprot

ncbitaxon 64091 181
type: UnificationXref
id: 64091
db: ncbitaxon

STATE_TRANSITION
type: InteractionVocabulary

Ferrochelatase-2, chloroplastic
type: ProteinReference
xref: uniprot O04921 43
organism: Arabidopsis thaliana

uniprot Q2KIN5 299
type: UnificationXref
id: Q2KIN5
db: uniprot

uroporphyrinogen-III
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P9WFV9 156
type: UnificationXref
id: P9WFV9
db: uniprot

uniprot Q8R695 22
type: UnificationXref
id: Q8R695
db: uniprot

uniprot A0A2I3RKG7 193
type: UnificationXref
id: A0A2I3RKG7
db: uniprot

uniprot Q9RX30 186
type: UnificationXref
id: Q9RX30
db: uniprot

uniprot F1PZA0 198
type: UnificationXref
id: F1PZA0
db: uniprot

uniprot Q58772 160
type: UnificationXref
id: Q58772
db: uniprot

ncbitaxon 189518 85
type: UnificationXref
id: 189518
db: ncbitaxon

Candida albicans
type: BioSource
xref: ncbitaxon 237561 290

uniprot Q7NHI9 108
type: UnificationXref
id: Q7NHI9
db: uniprot

Os01g0271200 protein
type: ProteinReference
xref: uniprot Q9LIZ8 184
organism: Oryza sativa

Glutamate--tRNA ligase
type: ProteinReference
xref: uniprot O84451 143
organism: Chlamydia trachomatis

FI03834p
type: ProteinReference
xref: uniprot Q9W0G4 308
organism: Drosophila melanogaster

Uroporphyrinogen decarboxylase
type: ProteinReference
xref: uniprot Q9V595 116
organism: Drosophila melanogaster

uniprot P16622 51
type: UnificationXref
id: P16622
db: uniprot

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot P30950 207
organism: Bacillus subtilis

Protoheme IX farnesyltransferase, mitochondrial
type: ProteinReference
xref: uniprot Q8CFY5 275
organism: Mus musculus

uniprot P9WMP5 212
type: UnificationXref
id: P9WMP5
db: uniprot

Oxygen-independent coproporphyrinogen-III oxidase-like protein
type: ProteinReference
xref: uniprot Q9X0P9 34
organism: Thermotoga maritima

uniprot F6U3X9 286
type: UnificationXref
id: F6U3X9
db: uniprot

Glutamate--tRNA ligase
type: ProteinReference
xref: uniprot P22250 149
organism: Bacillus subtilis

Porphobilinogen deaminase
type: ProteinReference
xref: uniprot P16616 292
organism: Bacillus subtilis

ncbitaxon 39947 63
type: UnificationXref
id: 39947
db: ncbitaxon

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot P13716 206
organism: Homo sapiens

uniprot Q8TT57 256
type: UnificationXref
id: Q8TT57
db: uniprot

ncbitaxon 243090 83
type: UnificationXref
id: 243090
db: ncbitaxon

uniprot Q7PRA2 164
type: UnificationXref
id: Q7PRA2
db: uniprot

Delta-aminolevulinic acid dehydratase
type: ProteinReference
xref: uniprot A8I980 194
organism: Chlamydomonas reinhardtii

Glutamate-1-semialdehyde 2,1-aminomutase
type: ProteinReference
xref: uniprot P30949 246
organism: Bacillus subtilis

uniprot Q9HMY5 305
type: UnificationXref
id: Q9HMY5
db: uniprot

Ferrochelatase, mitochondrial
type: ProteinReference
xref: uniprot P16622 51
organism: Saccharomyces cerevisiae

Radical S-adenosyl methionine domain-containing protein 1, mitochondrial
type: ProteinReference
xref: uniprot Q9HA92 26
organism: Homo sapiens

ncbitaxon 178306 176
type: UnificationXref
id: 178306
db: ncbitaxon

Porphobilinogen deaminase
type: ProteinReference
xref: uniprot Q2KIN5 299
organism: Bos taurus

uniprot Q9RZD8 90
type: UnificationXref
id: Q9RZD8
db: uniprot

uniprot Q9LIZ8 184
type: UnificationXref
id: Q9LIZ8
db: uniprot

Uroporphyrinogen decarboxylase 2, chloroplastic
type: ProteinReference
xref: uniprot O22886 97
organism: Arabidopsis thaliana

uniprot P32397 121
type: UnificationXref
id: P32397
db: uniprot