Guanine nucleotide-binding protein subunit gamma
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
Guanine nucleotide-binding protein G(t) subunit alpha-1
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Guanine nucleotide-binding protein G(T) subunit gamma-T1
Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
MODEL_NOTES=Panther Pathway: P00028 Phototransduction in the rod outer segment is mediated by a G-protein signaling pathway delineated by the photon-activated heptahelical transmembrane receptor Rhodopsin and its downstream heterotrimeric G-protein, Transducin. Rhodopsin's activation of Transducin alpha promotes the catalytic activity of Phosphodiesterase. The resultant decrease in cGMP forces cGMP-gated ion channels to close, intracellular sodium levels fall (hyperpolarization) and glutamate release at the synapse ceases, thus activating neighboring neurons, effectively propagating and amplifying the visual signal. Numerous proteins serve to modulate the pathway's level of amplification and also serve to dampen the signal's duration. Medline=11008492 Medline=11152756 Medline=11826267 Medline=11909550 PMID: 11008492 PMID: 11152756 PMID: 11826267 PMID: 11909550
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
cAMP-dependent protein kinase catalytic subunit alpha
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Guanine nucleotide-binding protein subunit beta-5
Protein kinase cAMP-activated catalytic subunit beta
cAMP-dependent protein kinase catalytic subunit beta
ENTITY_REFERENCE_NOTES=Long Name: Phosducin Synonym: Synonym not specified Accession: P00758
ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.Phosducin
Cyclic nucleotide-gated cation channel beta-3
Guanine nucleotide-binding protein subunit beta-5a
Cyclic nucleotide-gated cation channel alpha-3
ENTITY_REFERENCE_NOTES=Long Name: Rhodopsin kinase Synonym: Synonym not specified Accession: P00750
ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.Rhodopsin_br_kinase
ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.G_beta_
Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Complex (PDEalphabeta/PDEgamma/ Gtalpha)
cAMP-dependent protein kinase catalytic subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Cyclic nucleotide-gated cation channel beta-1
Guanine nucleotide-binding protein subunit beta-2
ENTITY_REFERENCE_NOTES=Long Name: Calmodulin Synonym: Synonym not specified Accession: P00755
ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.Calmodulin
ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.RGS9
ENTITY_REFERENCE_NOTES=Long Name: RGS9 Synonym: Synonym not specified Accession: P00749
Guanine nucleotide-binding protein subunit beta-1
Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
Guanine nucleotide-binding protein subunit beta-4
Guanine nucleotide-binding protein subunit beta
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.Recoverin
ENTITY_REFERENCE_NOTES=Long Name: Recoverin Synonym: Synonym not specified Accession: P00756
Cyclic nucleotide-gated channel rod photoreceptor subunit alpha
Complex (Rhodopsin/Gtalpha/ Gbeta/Ggamma/ Ligand)
ENTITY_REFERENCE_NOTES=Long Name: Protein kinase A Synonym: Synonym not specified Accession: P00746
ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.PKA
ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.G_gamma_
Guanine nucleotide-binding protein (G protein), beta 5
Protein kinase, cAMP-dependent, catalytic, beta
ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.RECEPTOR.Rhodopsin
ENTITY_REFERENCE_NOTES=Long Name: Rhodopsin Synonym: GiPCR Accession: P00747
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
ENTITY_REFERENCE_NOTES=Long Name: cGMP-gated ion channel Synonym: Synonym not specified Accession: P00752
ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.ION_CHANNEL.cGMP_minus_gated_br_ion_space_channel
cAMP-dependent protein kinase, catalytic subunit-like
Guanine nucleotide-binding protein (G protein), alpha transducing activity polypeptide 1
Guanine nucleotide-binding protein beta subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Guanine nucleotide binding protein 13, gamma-like
cAMP-dependent protein kinase catalytic subunit 1
Cyclic nucleotide gated channel alpha 3, isoform CRA_a
Guanine nucleotide binding protein, beta subunit
cAMP-dependent protein kinase catalytic subunit gamma
Protein kinase cAMP-activated catalytic subunit alpha
ENTITY_REFERENCE_NOTES=Long Name: Gtalpha Synonym: Synonym not specified Accession: P00760
ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.G_sub_t_endsub__alpha_
ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.G_beta_5L
ENTITY_REFERENCE_NOTES=Long Name: Gbeta5L Synonym: Synonym not specified Accession: P00748
cAMP-dependent protein kinase catalytic subunit alpha isoform 1
ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.PDE_alpha__beta_
ENTITY_REFERENCE_NOTES=Long Name: Phosphodiesterase alpha/beta subunits Synonym: Synonym not specified Accession: P00759
Complex (Rhodopsin/Gtalpha/ Gbeta/Ggamma)
ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.PDE_gamma_
ENTITY_REFERENCE_NOTES=Long Name: Phosphodiesterase gamma subunit Synonym: Synonym not specified Accession: P00754
Phosphodiesterase 6 gamma subunit rod form
cAMP-dependent protein kinase catalytic subunit beta isoform 1