uniprot F7H666 180
type: UnificationXref
id: F7H666
db: uniprot

Calmodulin
type: ProteinReference
xref: uniprot P62152 299
xref: PTHR23050:SF245
organism: Drosophila melanogaster

uniprot P50151 138
type: UnificationXref
id: P50151
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__Gbeta_Ggamma_-_Gtalpha-RIGHT__Complex__Gtalpha_Gbeta__Ggamma_-_r2
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 453
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 451
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 452
left: Gtalpha
left: Complex (Gbeta/Ggamma)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Gtalpha/Gbeta/ Ggamma)

PDEalphabeta
type: Protein
entity reference: PDEalphabeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s35 sa21 400
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR45695:SF9
type: RelationshipXref
id: PTHR45695:SF9
db: PANTHER Family
relationship type: By Homology

Calmodulin
type: ProteinReference
xref: PTHR23050:SF424
xref: uniprot P62149 298
organism: Gallus gallus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q5ZJ03 158
xref: PTHR13809:SF25
organism: Gallus gallus

G protein subunit gamma 13
type: ProteinReference
xref: PTHR15936:SF2
xref: uniprot F7F4P1 117
organism: Ornithorhynchus anatinus

uniprot P16499 335
type: UnificationXref
id: P16499
db: uniprot

uniprot P54311 230
type: UnificationXref
id: P54311
db: uniprot

PDC isoform 1
type: ProteinReference
xref: PTHR46052:SF3
xref: uniprot H2Q0S8 320
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rhodopsin_kinase-RIGHT__Rhodopsin_kinase-_r54
controller: Recoverin

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF67
xref: uniprot F6YFY5 347
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
type: ProteinReference
xref: PTHR15936:SF2
xref: uniprot Q9P2W3 171
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot A4IFL6 88
organism: Bos taurus

Guanine nucleotide-binding protein G(t) subunit alpha-1
type: ProteinReference
xref: uniprot P20612 350
xref: PTHR10218:SF67
organism: Mus musculus

PTHR12122:SF4
type: RelationshipXref
id: PTHR12122:SF4
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63212 146
xref: PTHR13809:SF25
organism: Bos taurus

uniprot E1C795 93
type: UnificationXref
id: E1C795
db: uniprot

Guanine nucleotide-binding protein G(T) subunit gamma-T1
type: ProteinReference
xref: uniprot P63211 145
xref: PTHR13809:SF26
organism: Homo sapiens

Guanine nucleotide-binding protein G(T) subunit gamma-T1
type: ProteinReference
xref: uniprot P63210 144
xref: PTHR13809:SF26
organism: Canis lupus familiaris

uniprot B3RJX8 273
type: UnificationXref
id: B3RJX8
db: uniprot

Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Rhodopsin_kinase-RIGHT__Rhodopsin_kinase-_r54
pathway component: DISSOCIATION_LEFT__GTP-_Complex__Rhodopsin_Gtalpha__Gbeta_Ggamma__Ligand_-RIGHT__Complex__Gbeta_Ggamma_-_GDP-_Gtalpha-_Complex__Ligand_Rhodopsin_-_r41
pathway component: STATE_TRANSITION_LEFT__Complex__Gbeta_Ggamma_-RIGHT__Complex__Gbeta_Ggamma_-_re22
pathway component: TRANSPORT_LEFT__Na_PLUS_-RIGHT__Na_PLUS_-_r52
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__PDEalphabeta_PDEgamma_-_Gtalpha-RIGHT__Complex__PDEalphabeta_PDEgamma__Gtalpha_-_r46
pathway component: STATE_TRANSITION_LEFT__Calmodulin-RIGHT__Calmodulin-_r56
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Gbeta_Ggamma_-_Gtalpha-RIGHT__Complex__Gtalpha_Gbeta__Ggamma_-_r2
pathway component: STATE_TRANSITION_LEFT__Complex__Rhodopsin_Gtalpha__Gbeta_Ggamma_-RIGHT__Complex__Rhodopsin_Gtalpha__Gbeta_Ggamma__Ligand_-_r44
pathway component: STATE_TRANSITION_LEFT__cGMP_gated_ion_channel-RIGHT__cGMP_gated_ion_channel-_r51
pathway component: STATE_TRANSITION_LEFT__Recoverin-RIGHT__Recoverin-_r55
pathway component: STATE_TRANSITION_LEFT__cGMP-RIGHT__5_GMP-_r50
pathway component: DISSOCIATION_LEFT__Complex__PDEgamma_Gtalpha_-RIGHT__Gtalpha-_P-_PDEgamma-_r48
pathway component: STATE_TRANSITION_LEFT__Phosducin-RIGHT__Phosducin-_r57
pathway component: STATE_TRANSITION_LEFT__ATP-_Complex__Ligand_Rhodopsin_-RIGHT__Rhodopsin-_ADP-_r43
pathway component: PHYSICAL_STIMULATION
pathway component: HETERODIMER_ASSOCIATION_LEFT__Rhodopsin-_Arrestin-RIGHT__Complex__Rhodopsin_Arrestin_-_r20
pathway component: DISSOCIATION_LEFT__Complex__PDEalphabeta_PDEgamma__Gtalpha_-RIGHT__Complex__PDEgamma_Gtalpha_-_PDEalphabeta-_r47
pathway component: HETERODIMER_ASSOCIATION_LEFT__Rhodopsin-_Complex__Gtalpha_Gbeta__Ggamma_-RIGHT__Complex__Rhodopsin_Gtalpha__Gbeta_Ggamma_-_r3
pathway component: HETERODIMER_ASSOCIATION_LEFT__PDEalphabeta-_PDEgamma-RIGHT__Complex__PDEalphabeta_PDEgamma_-_r49
pathway component: HETERODIMER_ASSOCIATION_LEFT__RGS9-_Gbeta5L-RIGHT__Complex__RGS9_Gbeta5L_-_r45
xref: PANTHER Pathway P00028 1
comment: MODEL_NOTES=Panther Pathway: P00028 Phototransduction in the rod outer segment is mediated by a G-protein signaling pathway delineated by the photon-activated heptahelical transmembrane receptor Rhodopsin and its downstream heterotrimeric G-protein, Transducin. Rhodopsin's activation of Transducin alpha promotes the catalytic activity of Phosphodiesterase. The resultant decrease in cGMP forces cGMP-gated ion channels to close, intracellular sodium levels fall (hyperpolarization) and glutamate release at the synapse ceases, thus activating neighboring neurons, effectively propagating and amplifying the visual signal. Numerous proteins serve to modulate the pathway's level of amplification and also serve to dampen the signal's duration. Medline=11008492 Medline=11152756 Medline=11826267 Medline=11909550 PMID: 11008492 PMID: 11152756 PMID: 11826267 PMID: 11909550

Calmodulin
type: ProteinReference
xref: uniprot P62157 300
xref: PTHR23050:SF381
organism: Bos taurus

uniprot P06002 58
type: UnificationXref
id: P06002
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 28

PDEalphabeta
type: Protein
entity reference: PDEalphabeta
feature: ACTIVE 47
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Gbeta s17 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

PRKACB isoform 3
type: ProteinReference
xref: uniprot H2R1G3 21
xref: PTHR24353:SF116
organism: Pan troglodytes

uniprot J9P702 129
type: UnificationXref
id: J9P702
db: uniprot

uniprot Q7ZVI5 259
type: UnificationXref
id: Q7ZVI5
db: uniprot

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa82 356
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A4IHC2 248
type: UnificationXref
id: A4IHC2
db: uniprot

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
type: ProteinReference
xref: uniprot P33726 341
organism: Canis lupus familiaris

uniprot A0A0D1DU81 261
type: UnificationXref
id: A0A0D1DU81
db: uniprot

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__PDEgamma_Gtalpha_-RIGHT__Gtalpha-_P-_PDEgamma-_r48
controller: Complex (RGS9/Gbeta5L)

PTHR24240:SF15
type: RelationshipXref
id: PTHR24240:SF15
db: PANTHER Family
relationship type: By Homology

uniprot P63210 144
type: UnificationXref
id: P63210
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P17612 31
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 236
xref: PTHR19850:SF27
organism: Homo sapiens

Rhodopsin kinase
type: ProteinReference
xref: uniprot Q9WVL4 87
xref: PTHR24355:SF11
organism: Mus musculus

uniprot P62872 233
type: UnificationXref
id: P62872
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 235
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 233
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 234
organism: Homo sapiens

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot P62881 74
xref: PTHR19850:SF36
organism: Mus musculus

uniprot P00517 23
type: UnificationXref
id: P00517
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 237
xref: PTHR19850:SF27
organism: Mus musculus

Protein kinase cAMP-activated catalytic subunit beta
type: ProteinReference
xref: uniprot F6T0T9 12
xref: PTHR24353:SF116
organism: Xenopus tropicalis

uniprot P0DP29 295
type: UnificationXref
id: P0DP29
db: uniprot

Rhodopsin
type: ProteinReference
xref: uniprot F7BN33 53
xref: PTHR24240:SF15
organism: Xenopus tropicalis

uniprot Q61016 160
type: UnificationXref
id: Q61016
db: uniprot

Rhodopsin
type: ProteinReference
xref: uniprot P51489 64
xref: PTHR24240:SF15
organism: Rattus norvegicus

RCVRN isoform 1
type: ProteinReference
xref: PTHR23055:SF20
xref: uniprot H2QC95 315
organism: Pan troglodytes

uniprot Q9DAS9 168
type: UnificationXref
id: Q9DAS9
db: uniprot

uniprot Q9JJZ9 194
type: UnificationXref
id: Q9JJZ9
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 211

uniprot A4IHG6 345
type: UnificationXref
id: A4IHG6
db: uniprot

uniprot P04972 252
type: UnificationXref
id: P04972
db: uniprot

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa15 386
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P35359 63
type: UnificationXref
id: P35359
db: uniprot

G protein-coupled receptor kinase
type: ProteinReference
xref: uniprot F6SX33 80
xref: PTHR24355:SF11
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 232
organism: Bos taurus

Regulator of G-protein signaling 9
type: ProteinReference
xref: uniprot O54828 78
xref: PTHR45746:SF1
organism: Mus musculus

Rhodopsin
type: Protein
entity reference: Rhodopsin
feature: COMPLEX PARTICIPANT BINDING FEATURE s147 sa17 404
feature: Rhodopsin s147 sa17 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Calmodulin
type: ProteinReference
xref: uniprot E9H5Z2 282
xref: PTHR23050:SF245
organism: Daphnia pulex

Gtalpha s16 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gtalpha
stoichiometric coefficient: 1.0

Opsin Rh1
type: ProteinReference
xref: uniprot P06002 58
xref: PTHR24240:SF85
organism: Drosophila melanogaster

ncbitaxon 237631 262
type: UnificationXref
id: 237631
db: ncbitaxon

uniprot P27791 35
type: UnificationXref
id: P27791
db: uniprot

PTHR45746:SF1
type: RelationshipXref
id: PTHR45746:SF1
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__RGS9-_Gbeta5L-RIGHT__Complex__RGS9_Gbeta5L_-_r45
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 434
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 433
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 435
left: RGS9
left: Gbeta5L
interaction type: HETERODIMER_ASSOCIATION
right: Complex (RGS9/Gbeta5L)

Protein CBR-CMD-1
type: ProteinReference
xref: uniprot A8WPJ8 267
xref: PTHR23050:SF401
organism: Caenorhabditis briggsae

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 19

AGAP002462-PA
type: ProteinReference
xref: PTHR24240:SF85
xref: uniprot Q7QC57 66
organism: Anopheles gambiae

uniprot P30671 135
type: UnificationXref
id: P30671
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P68182 38
xref: PTHR24353:SF116
organism: Rattus norvegicus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P68181 37
xref: PTHR24353:SF116
organism: Mus musculus

Predicted protein
type: ProteinReference
xref: uniprot A7SCT6 266
xref: PTHR23050:SF245
organism: Nematostella vectensis

Gtalpha s16 sa14 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Phosducin
type: ProteinReference
xref: P00758
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosducin Synonym: Synonym not specified Accession: P00758
comment: ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.Phosducin
member entity reference: PDC isoform 1
member entity reference: Phosducin

uniprot Q6PH57 245
type: UnificationXref
id: Q6PH57
db: uniprot

uniprot F7F1T7 178
type: UnificationXref
id: F7F1T7
db: uniprot

uniprot P34057 317
type: UnificationXref
id: P34057
db: uniprot

Cyclic nucleotide-gated cation channel beta-3
type: ProteinReference
xref: PTHR45638:SF8
xref: uniprot Q9JJZ9 194
organism: Mus musculus

Guanine nucleotide-binding protein subunit beta-5a
type: ProteinReference
xref: uniprot A1L271 67
xref: PTHR19850:SF40
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZSF0 202
organism: Branchiostoma floridae

uniprot P20942 323
type: UnificationXref
id: P20942
db: uniprot

uniprot P02699 57
type: UnificationXref
id: P02699
db: uniprot

Rhodopsin s147 sa17 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot O16305 291
type: UnificationXref
id: O16305
db: uniprot

PARTICIPANT STOICHIOMETRY r3 449
type: Stoichiometry
physical entity: Complex (Gtalpha/Gbeta/ Ggamma)
stoichiometric coefficient: 1.0

Phosducin
type: ProteinReference
xref: PTHR46052:SF3
xref: uniprot Q9QW08 324
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r3 448
type: Stoichiometry
physical entity: Rhodopsin
stoichiometric coefficient: 1.0

Cyclic nucleotide-gated cation channel alpha-3
type: ProteinReference
xref: uniprot Q9JJZ8 193
xref: PTHR45638:SF6
organism: Mus musculus

uniprot H2QWE1 181
type: UnificationXref
id: H2QWE1
db: uniprot

uniprot Q9HAV0 247
type: UnificationXref
id: Q9HAV0
db: uniprot

uniprot Q9NQW8 195
type: UnificationXref
id: Q9NQW8
db: uniprot

uniprot C3ZEW0 277
type: UnificationXref
id: C3ZEW0
db: uniprot

uniprot F6SSS3 104
type: UnificationXref
id: F6SSS3
db: uniprot

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 212
organism: Ornithorhynchus anatinus

Rhodopsin kinase
type: ProteinReference
xref: P00750
comment: ENTITY_REFERENCE_NOTES=Long Name: Rhodopsin kinase Synonym: Synonym not specified Accession: P00750
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.Rhodopsin_br_kinase
member entity reference: Rhodopsin kinase
member entity reference: G protein-coupled receptor kinase
member entity reference: G protein-coupled receptor kinase 2
member entity reference: G protein-coupled receptor kinase 1

GDP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q14028 185
type: UnificationXref
id: Q14028
db: uniprot

PDEgamma s36 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PDEgamma
stoichiometric coefficient: 1.0

Gbeta
type: ProteinReference
xref: P00753
standard name: G protein, beta subunit
comment: ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.G_beta_
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: Guanine nucleotide-binding protein subunit beta-1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Guanine nucleotide-binding protein subunit beta-4
member entity reference: Uncharacterized protein
member entity reference: G protein subunit beta 4
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: Guanine nucleotide-binding protein beta subunit
member entity reference: Guanine nucleotide-binding protein subunit beta-2
member entity reference: G protein subunit beta 1
member entity reference: THO complex subunit, putative
member entity reference: Guanine nucleotide binding protein, beta subunit
member entity reference: G protein subunit beta 2
member entity reference: G-protein beta subunit
member entity reference: Gnb1l protein
member entity reference: Gnb2 protein
member entity reference: GNB4 protein

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot E2R9G5 97
organism: Canis lupus familiaris

eco ECO:0000245 336
type: UnificationXref
id: ECO:0000245
db: eco

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: PTHR19850:SF36
xref: uniprot O14775 72
organism: Homo sapiens

ncbitaxon 81824 272
type: UnificationXref
id: 81824
db: ncbitaxon

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 205
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot E2R2S3 95
organism: Canis lupus familiaris

uniprot Q16281 186
type: UnificationXref
id: Q16281
db: uniprot

PDEgamma
type: Protein
entity reference: PDEgamma
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Gtalpha s28 sa11 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR11347:SF73
type: RelationshipXref
id: PTHR11347:SF73
db: PANTHER Family
relationship type: By Homology

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__Complex__Gbeta_Ggamma_-RIGHT__Complex__Gbeta_Ggamma_-_re22
controller: Phosducin

uniprot F7CLC0 286
type: UnificationXref
id: F7CLC0
db: uniprot

MODULATION
type: RelationshipTypeVocabulary

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

uniprot H2QZN8 128
type: UnificationXref
id: H2QZN8
db: uniprot

uniprot W4YPT6 312
type: UnificationXref
id: W4YPT6
db: uniprot

PARTICIPANT STOICHIOMETRY r3 450
type: Stoichiometry
physical entity: Complex (Rhodopsin/Gtalpha/ Gbeta/Ggamma)
stoichiometric coefficient: 1.0

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 15

00696
type: UnificationXref
id: MOD:00696
db: mod

Evidence 328
type: Evidence
evidence code: ISS
comment: SPACC P35913

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF383
xref: uniprot J9NXY2 290
organism: Canis lupus familiaris

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
type: ProteinReference
xref: PTHR24353:SF135
xref: uniprot Q6DBV8 40
organism: Danio rerio

Evidence 326
type: Evidence
evidence code: ISS
comment: SPACC P27664

Gtalpha s21 sa4 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F6SV58 283
type: UnificationXref
id: F6SV58
db: uniprot

uniprot P63213 147
type: UnificationXref
id: P63213
db: uniprot

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
type: ProteinReference
xref: uniprot P16499 335
xref: PTHR11347:SF115
organism: Homo sapiens

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
type: ProteinReference
evidence: Evidence 258
xref: PTHR12122:SF4
xref: uniprot P54827 257
organism: Canis lupus familiaris

uniprot F5HMX8 51
type: UnificationXref
id: F5HMX8
db: uniprot

Physcomitrella patens
type: BioSource
xref: ncbitaxon 3218 269

Gtalpha s8 a8 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot B7Q3T6 200
type: UnificationXref
id: B7Q3T6
db: uniprot

PTHR19850:SF27
type: RelationshipXref
id: PTHR19850:SF27
db: PANTHER Family
relationship type: By Homology

Rhodopsin s146 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rhodopsin
stoichiometric coefficient: 1.0

uniprot Q5BH99 240
type: UnificationXref
id: Q5BH99
db: uniprot

Phosphodiesterase
type: ProteinReference
evidence: Evidence 326
xref: PTHR11347:SF115
xref: uniprot E1BK80 329
organism: Bos taurus

uniprot Q61012 159
type: UnificationXref
id: Q61012
db: uniprot

uniprot F6PVT7 213
type: UnificationXref
id: F6PVT7
db: uniprot

Complex (PDEalphabeta/PDEgamma/ Gtalpha)
type: Complex
component stoichiometry: PDEalphabeta s37 sa23 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gtalpha s39 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: PDEgamma s38 sa24 STOICHIOMETRY ID COMPLEX
component: PDEgamma
component: PDEalphabeta
component: Gtalpha
feature: COMPLEX BINDING FEATURE s126 a160 389
feature: COMPLEX BINDING FEATURE s126 a160 393
feature: COMPLEX BINDING FEATURE s126 a160 391
cellular location: cytosol

Gbeta s3 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__cGMP_gated_ion_channel-RIGHT__cGMP_gated_ion_channel-_r51
controller: cGMP

uniprot Q5KI86 243
type: UnificationXref
id: Q5KI86
db: uniprot

DISSOCIATION
type: RelationshipTypeVocabulary

uniprot E2R7K4 96
type: UnificationXref
id: E2R7K4
db: uniprot

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot A8XW88 9
xref: PTHR24353:SF117
organism: Caenorhabditis briggsae

Evidence 343
type: Evidence
evidence code: RCA
comment: SPACC P35913

Calmodulin
type: ProteinReference
xref: PTHR23050:SF245
xref: uniprot E3KLJ3 280
organism: Puccinia graminis

Evidence 340
type: Evidence
evidence code: RCA
comment: SPACC P27664

ncbitaxon 10116 36
type: UnificationXref
id: 10116
db: ncbitaxon

Predicted protein
type: ProteinReference
xref: PTHR23050:SF245
xref: uniprot A9V8J8 271
organism: Monosiga brevicollis

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot P50150 137
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot P50151 138
xref: PTHR13809:SF6
organism: Homo sapiens

uniprot F5HMY2 52
type: UnificationXref
id: F5HMY2
db: uniprot

uniprot Q3KRE3 156
type: UnificationXref
id: Q3KRE3
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: PTHR13809:SF28
xref: uniprot P50154 140
organism: Bos taurus

uniprot P59220 297
type: UnificationXref
id: P59220
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot P50153 139
organism: Mus musculus

G protein subunit gamma 13
type: ProteinReference
xref: PTHR15936:SF2
xref: uniprot E2R7K4 96
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r20 415
type: Stoichiometry
physical entity: Complex (Rhodopsin/Arrestin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 414
type: Stoichiometry
physical entity: Arrestin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 413
type: Stoichiometry
physical entity: Rhodopsin
stoichiometric coefficient: 1.0

uniprot Q7QC57 66
type: UnificationXref
id: Q7QC57
db: uniprot

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa16 388
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR19850:SF40
type: RelationshipXref
id: PTHR19850:SF40
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r47 429
type: Stoichiometry
physical entity: PDEalphabeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r47 427
type: Stoichiometry
physical entity: Complex (PDEalphabeta/PDEgamma/ Gtalpha)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r47 428
type: Stoichiometry
physical entity: Complex (PDEgamma/Gtalpha)
stoichiometric coefficient: 1.0

uniprot A0A2J8P954 344
type: UnificationXref
id: A0A2J8P954
db: uniprot

uniprot Q7PX14 65
type: UnificationXref
id: Q7PX14
db: uniprot

Calmodulin-7
type: ProteinReference
xref: uniprot P59220 297
xref: PTHR23050:SF438
organism: Arabidopsis thaliana

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P27791 35
organism: Rattus norvegicus

Puccinia graminis
type: BioSource
xref: ncbitaxon 418459 281

uniprot G3V6P8 121
type: UnificationXref
id: G3V6P8
db: uniprot

uniprot F7CXV2 251
type: UnificationXref
id: F7CXV2
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot P32865 82
type: UnificationXref
id: P32865
db: uniprot

G protein subunit gamma 13
type: ProteinReference
xref: PTHR15936:SF2
xref: uniprot G3V8Y0 123
organism: Rattus norvegicus

Ggamma s30 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

Calmodulin
type: Protein
entity reference: Calmodulin
feature: ACTIVE 47
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P63216 150
type: UnificationXref
id: P63216
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF9
xref: uniprot G3V6P8 121
organism: Rattus norvegicus

Phosducin
type: ProteinReference
xref: PTHR46052:SF3
xref: uniprot F1MSE1 319
organism: Bos taurus

PTHR19850:SF36
type: RelationshipXref
id: PTHR19850:SF36
db: PANTHER Family
relationship type: By Homology

ncbitaxon 559292 223
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot E3KLJ3 280
type: UnificationXref
id: E3KLJ3
db: uniprot

uniprot P27482 296
type: UnificationXref
id: P27482
db: uniprot

uniprot P68182 38
type: UnificationXref
id: P68182
db: uniprot

PTHR45638:SF16
type: RelationshipXref
id: PTHR45638:SF16
db: PANTHER Family
relationship type: By Homology

G protein subunit beta 5
type: ProteinReference
xref: PTHR19850:SF36
xref: uniprot H2Q9G5 71
organism: Pan troglodytes

Phosphodiesterase
type: ProteinReference
evidence: Evidence 326
xref: uniprot H2QRS2 334
xref: PTHR11347:SF115
organism: Pan troglodytes

uniprot F7GZN6 179
type: UnificationXref
id: F7GZN6
db: uniprot

PTHR13809:SF5
type: RelationshipXref
id: PTHR13809:SF5
db: PANTHER Family
relationship type: By Homology

uniprot D3ZSS5 346
type: UnificationXref
id: D3ZSS5
db: uniprot

uniprot F6V461 106
type: UnificationXref
id: F6V461
db: uniprot

uniprot P12370 29
type: UnificationXref
id: P12370
db: uniprot

ncbitaxon 13616 17
type: UnificationXref
id: 13616
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot P63219 153
organism: Rattus norvegicus

Gtalpha s12 a13 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 152
xref: PTHR13809:SF5
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63217 151
xref: PTHR13809:SF5
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63216 150
xref: PTHR13809:SF11
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 149
xref: PTHR13809:SF11
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot P63214 148
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H666 180
xref: PTHR45638:SF16
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63213 147
xref: PTHR13809:SF25
organism: Mus musculus

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 8

uniprot Q9D6P8 309
type: UnificationXref
id: Q9D6P8
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q15KE4 154
xref: PTHR13809:SF25
organism: Danio rerio

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 42

Cyclic nucleotide-gated cation channel beta-1
type: ProteinReference
xref: uniprot Q28181 187
xref: PTHR45638:SF16
organism: Bos taurus

HETERODIMER_ASSOCIATION_LEFT__Complex__PDEalphabeta_PDEgamma_-_Gtalpha-RIGHT__Complex__PDEalphabeta_PDEgamma__Gtalpha_-_r46
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 430
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 431
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 432
left: Gtalpha
left: Complex (PDEalphabeta/PDEgamma)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (PDEalphabeta/PDEgamma/ Gtalpha)

uniprot Q5BJ11 242
type: UnificationXref
id: Q5BJ11
db: uniprot

PDEalphabeta s35 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PDEalphabeta
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot P29829 225
organism: Drosophila melanogaster

Gtalpha s41 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gtalpha
stoichiometric coefficient: 1.0

uniprot F6TFY2 105
type: UnificationXref
id: F6TFY2
db: uniprot

Calmodulin
type: ProteinReference
xref: P00755
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Calmodulin Synonym: Synonym not specified Accession: P00755
comment: ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.Calmodulin
member entity reference: Uncharacterized protein
member entity reference: Calmodulin-like protein 3
member entity reference: Putative calmodulin
member entity reference: Predicted protein (Fragment)
member entity reference: Calmodulin-7
member entity reference: Calmodulin
member entity reference: Calmodulin-1
member entity reference: Predicted protein
member entity reference: AGAP010957-PA (Fragment)
member entity reference: Calmodulin 1
member entity reference: Calmodulin-3
member entity reference: Protein CBR-CMD-1
member entity reference: Calmodulin-2

Cyclic nucleotide-gated cation channel alpha-3
type: ProteinReference
xref: uniprot Q16281 186
xref: PTHR45638:SF6
organism: Homo sapiens

Calmodulin
type: Protein
entity reference: Calmodulin
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P32308 62
type: UnificationXref
id: P32308
db: uniprot

uniprot Q28024 155
type: UnificationXref
id: Q28024
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot F7F580 118
organism: Macaca mulatta

RGS9
type: ProteinReference
xref: P00749
standard name: Regulator of G-protein signaling 9
comment: ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.RGS9
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: RGS9 Synonym: Synonym not specified Accession: P00749
member entity reference: Regulator of G-protein-signaling 9
member entity reference: RGS9 isoform 3
member entity reference: Regulator of G-protein signaling 9
member entity reference: Regulator of G protein signaling 9

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot Q9CXP8 167
organism: Mus musculus

uniprot P63217 151
type: UnificationXref
id: P63217
db: uniprot

uniprot F7G4Q0 16
type: UnificationXref
id: F7G4Q0
db: uniprot

uniprot P62879 236
type: UnificationXref
id: P62879
db: uniprot

uniprot H2QNC5 55
type: UnificationXref
id: H2QNC5
db: uniprot

uniprot H2QRS2 334
type: UnificationXref
id: H2QRS2
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot E2RGI5 98
organism: Canis lupus familiaris

uniprot Q80SZ7 165
type: UnificationXref
id: Q80SZ7
db: uniprot

uniprot D3ZDI8 327
type: UnificationXref
id: D3ZDI8
db: uniprot

uniprot Q8MJ44 45
type: UnificationXref
id: Q8MJ44
db: uniprot

ncbitaxon 418459 281
type: UnificationXref
id: 418459
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Complex__Ligand_Rhodopsin_-RIGHT__Rhodopsin-_ADP-_r43
controller: Rhodopsin kinase

PDEgamma s40 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PDEgamma
stoichiometric coefficient: 1.0

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
type: ProteinReference
evidence: Evidence 255
xref: PTHR12122:SF4
xref: uniprot P09174 254
organism: Mus musculus

uniprot J9NWQ5 289
type: UnificationXref
id: J9NWQ5
db: uniprot

G protein-coupled receptor kinase 1
type: ProteinReference
xref: uniprot P32865 82
organism: Drosophila melanogaster

ncbitaxon 39947 302
type: UnificationXref
id: 39947
db: ncbitaxon

TRANSPORT
type: RelationshipTypeVocabulary

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 199

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 244

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P17343 221
organism: Caenorhabditis elegans

Calmodulin 1
type: ProteinReference
xref: PTHR23050:SF381
xref: uniprot E2REK6 279
organism: Canis lupus familiaris

uniprot H2Q1D9 125
type: UnificationXref
id: H2Q1D9
db: uniprot

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 336

PTHR24353:SF137
type: RelationshipXref
id: PTHR24353:SF137
db: PANTHER Family
relationship type: By Homology

uniprot P11488 349
type: UnificationXref
id: P11488
db: uniprot

PTHR24353:SF135
type: RelationshipXref
id: PTHR24353:SF135
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3SZ98 157
xref: PTHR13809:SF6
organism: Bos taurus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Glutamate release
controller: Na+

uniprot A1L271 67
type: UnificationXref
id: A1L271
db: uniprot

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa5 366
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2R1G3 21
type: UnificationXref
id: H2R1G3
db: uniprot

uniprot A7EDU2 198
type: UnificationXref
id: A7EDU2
db: uniprot

Phosphodiesterase
type: ProteinReference
evidence: Evidence 326
xref: PTHR11347:SF115
xref: uniprot F7G5L8 333
organism: Ornithorhynchus anatinus

ncbitaxon 10090 28
type: UnificationXref
id: 10090
db: ncbitaxon

Rhodopsin
type: ProteinReference
xref: PTHR24240:SF15
xref: uniprot P15409 61
organism: Mus musculus

uniprot P23439 337
type: UnificationXref
id: P23439
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SV58 283
xref: PTHR23050:SF383
organism: Monodelphis domestica

uniprot F7EG53 313
type: UnificationXref
id: F7EG53
db: uniprot

Gtalpha s39 sa25 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A8XW88 9
type: UnificationXref
id: A8XW88
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 203

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF9
xref: uniprot F6SSS3 104
organism: Monodelphis domestica

ncbitaxon 9544 15
type: UnificationXref
id: 9544
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot H2Q1D9 125
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6W548 108
xref: PTHR13809:SF6
organism: Macaca mulatta

Predicted protein
type: ProteinReference
xref: PTHR23050:SF245
xref: uniprot A9SHH7 270
organism: Physcomitrella patens

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 5

Arrestin
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa18 406
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Recoverin-RIGHT__Recoverin-_r55
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 460
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 461
left: Recoverin
interaction type: STATE_TRANSITION
right: Recoverin

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A1D5QR46 175
type: UnificationXref
id: A0A1D5QR46
db: uniprot

uniprot C3XRD1 275
type: UnificationXref
id: C3XRD1
db: uniprot

Ligand s7 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ligand
stoichiometric coefficient: 1.0

uniprot Q3SZ98 157
type: UnificationXref
id: Q3SZ98
db: uniprot

STATE_TRANSITION_LEFT__Calmodulin-RIGHT__Calmodulin-_r56
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 458
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 459
left: Calmodulin
interaction type: STATE_TRANSITION
right: Calmodulin

uniprot E2RJB3 99
type: UnificationXref
id: E2RJB3
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P00517 23
organism: Bos taurus

uniprot E9GNI4 10
type: UnificationXref
id: E9GNI4
db: uniprot

PARTICIPANT STOICHIOMETRY r44 437
type: Stoichiometry
physical entity: Complex (Rhodopsin/Gtalpha/ Gbeta/Ggamma/ Ligand)
stoichiometric coefficient: 1.0

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 17

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot K7AE17 130
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 204
organism: Gallus gallus

Predicted protein
type: ProteinReference
xref: uniprot A7RPI8 263
xref: PTHR23050:SF245
organism: Nematostella vectensis

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 285

PARTICIPANT STOICHIOMETRY r44 436
type: Stoichiometry
physical entity: Complex (Rhodopsin/Gtalpha/ Gbeta/Ggamma)
stoichiometric coefficient: 1.0

uniprot F1MYX4 76
type: UnificationXref
id: F1MYX4
db: uniprot

PTHR13809:SF6
type: RelationshipXref
id: PTHR13809:SF6
db: PANTHER Family
relationship type: By Homology

PTHR13809:SF9
type: RelationshipXref
id: PTHR13809:SF9
db: PANTHER Family
relationship type: By Homology

PTHR13809:SF8
type: RelationshipXref
id: PTHR13809:SF8
db: PANTHER Family
relationship type: By Homology

uniprot W4XNQ0 310
type: UnificationXref
id: W4XNQ0
db: uniprot

uniprot D4AAI1 91
type: UnificationXref
id: D4AAI1
db: uniprot

PTHR24353:SF117
type: RelationshipXref
id: PTHR24353:SF117
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF116
type: RelationshipXref
id: PTHR24353:SF116
db: PANTHER Family
relationship type: By Homology

Na+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
type: ProteinReference
xref: uniprot A3KMS9 3
xref: PTHR24353:SF82
organism: Danio rerio

uniprot F7F2J1 54
type: UnificationXref
id: F7F2J1
db: uniprot

uniprot P08100 60
type: UnificationXref
id: P08100
db: uniprot

cGMP-gated cation channel alpha-1
type: ProteinReference
xref: PTHR45638:SF9
xref: uniprot Q00194 184
organism: Bos taurus

uniprot Q6PI52 307
type: UnificationXref
id: Q6PI52
db: uniprot

uniprot H2QXB9 20
type: UnificationXref
id: H2QXB9
db: uniprot

uniprot R4GKD1 174
type: UnificationXref
id: R4GKD1
db: uniprot

uniprot P09174 254
type: UnificationXref
id: P09174
db: uniprot

Rhodopsin s20 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rhodopsin
stoichiometric coefficient: 1.0

Predicted protein (Fragment)
type: ProteinReference
xref: PTHR23050:SF245
xref: uniprot A7RPN8 265
organism: Nematostella vectensis

uniprot A8XJQ6 7
type: UnificationXref
id: A8XJQ6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 218
organism: Monodelphis domestica

ncbitaxon 9913 24
type: UnificationXref
id: 9913
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Phosducin-RIGHT__Phosducin-_r57
controller: PKA

Rhodopsin kinase
type: ProteinReference
xref: PTHR24355:SF11
xref: uniprot P28327 81
organism: Bos taurus

uniprot P63215 149
type: UnificationXref
id: P63215
db: uniprot

uniprot A7RPI8 263
type: UnificationXref
id: A7RPI8
db: uniprot

uniprot P49177 228
type: UnificationXref
id: P49177
db: uniprot

uniprot Q61017 161
type: UnificationXref
id: Q61017
db: uniprot

By Homology
type: RelationshipTypeVocabulary

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Calmodulin-RIGHT__Calmodulin-_r56
controller: Ca2+

cGMP-gated cation channel alpha-1
type: ProteinReference
xref: uniprot P29973 182
xref: PTHR45638:SF9
organism: Homo sapiens

uniprot F6VPY1 107
type: UnificationXref
id: F6VPY1
db: uniprot

cGMP-gated cation channel alpha-1
type: ProteinReference
xref: uniprot P29974 183
xref: PTHR45638:SF9
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DF43 162
xref: PTHR13809:SF25
organism: Xenopus tropicalis

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P05132 27
organism: Mus musculus

Complex (RGS9/Gbeta5L)
type: Complex
component stoichiometry: Gbeta5L s34 sa20 STOICHIOMETRY ID COMPLEX
component stoichiometry: RGS9 s33 sa19 STOICHIOMETRY ID COMPLEX
component: Gbeta5L
component: RGS9
feature: COMPLEX BINDING FEATURE s122 a143 373
feature: COMPLEX BINDING FEATURE s122 a143 371
cellular location: cytosol

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P05131 26
xref: PTHR24353:SF116
organism: Bos taurus

uniprot F6Y3N2 214
type: UnificationXref
id: F6Y3N2
db: uniprot

Ligand
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa7 370
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PDEgamma s38 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PDEgamma
stoichiometric coefficient: 1.0

Rhodopsin
type: Protein
entity reference: Rhodopsin
feature: Rhodopsin s20 sa3 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa3 362
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r50 419
type: Stoichiometry
physical entity: 5-GMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r50 418
type: Stoichiometry
physical entity: cGMP
stoichiometric coefficient: 1.0

uniprot A9SHH7 270
type: UnificationXref
id: A9SHH7
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 247
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR15936:SF2
xref: uniprot F6XII5 110
organism: Monodelphis domestica

ncbitaxon 9598 19
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot E2R2S3 95
type: UnificationXref
id: E2R2S3
db: uniprot

Rhodopsin s9 sa2 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot Q10282 238
organism: Schizosaccharomyces pombe

PANTHER Pathway P00028 1
type: UnificationXref
id: P00028
db: PANTHER Pathway

uniprot F7H6T7 70
type: UnificationXref
id: F7H6T7
db: uniprot

P00747
type: UnificationXref
id: P00747
db: PANTHER Pathway Component

P00748
type: UnificationXref
id: P00748
db: PANTHER Pathway Component

ncbitaxon 3702 229
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot O60262 133
type: UnificationXref
id: O60262
db: uniprot

P00746
type: UnificationXref
id: P00746
db: PANTHER Pathway Component

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot E2RJB3 99
organism: Canis lupus familiaris

P00749
type: UnificationXref
id: P00749
db: PANTHER Pathway Component

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 229

uniprot F7G3J2 218
type: UnificationXref
id: F7G3J2
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P18851 222
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r56 458
type: Stoichiometry
physical entity: Calmodulin
stoichiometric coefficient: 1.0

Gtalpha
type: Protein
entity reference: Gtalpha
feature: Gtalpha s8 a8 rs1
feature: ACTIVE 47
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r56 459
type: Stoichiometry
physical entity: Calmodulin
stoichiometric coefficient: 1.0

G protein subunit gamma 5
type: ProteinReference
xref: PTHR13809:SF51
xref: uniprot H2PZA6 124
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1PJE5 101
xref: PTHR13809:SF19
organism: Canis lupus familiaris

ncbitaxon 8364 13
type: UnificationXref
id: 8364
db: ncbitaxon

P00751
type: UnificationXref
id: P00751
db: PANTHER Pathway Component

P00750
type: UnificationXref
id: P00750
db: PANTHER Pathway Component

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot Q9UK08 173
xref: PTHR13809:SF19
organism: Homo sapiens

P00752
type: UnificationXref
id: P00752
db: PANTHER Pathway Component

Calmodulin-1
type: ProteinReference
xref: uniprot P0DP29 295
xref: PTHR23050:SF383
organism: Rattus norvegicus

P00753
type: UnificationXref
id: P00753
db: PANTHER Pathway Component

Regulator of G protein signaling 9
type: ProteinReference
xref: uniprot J9P1Y8 77
xref: PTHR45746:SF1
organism: Canis lupus familiaris

P00754
type: UnificationXref
id: P00754
db: PANTHER Pathway Component

P00755
type: UnificationXref
id: P00755
db: PANTHER Pathway Component

P00756
type: UnificationXref
id: P00756
db: PANTHER Pathway Component

uniprot Q6F332 306
type: UnificationXref
id: Q6F332
db: uniprot

P00758
type: UnificationXref
id: P00758
db: PANTHER Pathway Component

P00759
type: UnificationXref
id: P00759
db: PANTHER Pathway Component

Calmodulin-3
type: ProteinReference
xref: PTHR23050:SF381
xref: uniprot P0DP28 294
organism: Mus musculus

uniprot P23440 338
type: UnificationXref
id: P23440
db: uniprot

Calmodulin-1
type: ProteinReference
xref: uniprot P0DP23 293
xref: PTHR23050:SF427
organism: Homo sapiens

AGAP010957-PA (Fragment)
type: ProteinReference
xref: PTHR23050:SF245
xref: uniprot Q7QGY7 308
organism: Anopheles gambiae

Danio rerio
type: BioSource
xref: ncbitaxon 7955 4

Gtalpha s21 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gtalpha
stoichiometric coefficient: 1.0

uniprot Q6DF43 162
type: UnificationXref
id: Q6DF43
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot Q8MJ44 45
xref: PTHR24353:SF82
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot E9GNI4 10
organism: Daphnia pulex

ncbitaxon 6239 42
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot A0NH90 48
type: UnificationXref
id: A0NH90
db: uniprot

P00760
type: UnificationXref
id: P00760
db: PANTHER Pathway Component

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 196
xref: PTHR19850:SF27
organism: Pan troglodytes

uniprot Q63651 86
type: UnificationXref
id: Q63651
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Na_PLUS_-RIGHT__Na_PLUS_-_r52
control type: ACTIVATION
controller: cGMP-gated ion channel

IDA
type: EvidenceCodeVocabulary

PDEgamma
type: Protein
entity reference: PDEgamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s40 sa26 396
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7F4P1 117
type: UnificationXref
id: F7F4P1
db: uniprot

Calmodulin-like protein 3
type: ProteinReference
xref: PTHR23050:SF389
xref: uniprot Q9D6P8 309
organism: Mus musculus

PTHR45638:SF8
type: RelationshipXref
id: PTHR45638:SF8
db: PANTHER Family
relationship type: By Homology

uniprot Q00194 184
type: UnificationXref
id: Q00194
db: uniprot

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 262

PTHR45638:SF9
type: RelationshipXref
id: PTHR45638:SF9
db: PANTHER Family
relationship type: By Homology

PTHR45638:SF6
type: RelationshipXref
id: PTHR45638:SF6
db: PANTHER Family
relationship type: By Homology

uniprot F6ZK66 249
type: UnificationXref
id: F6ZK66
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 112
xref: PTHR13809:SF19
organism: Monodelphis domestica

Rhodopsin kinase
type: ProteinReference
xref: uniprot Q15835 84
xref: PTHR24355:SF11
organism: Homo sapiens

Arrestin s14 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Arrestin
stoichiometric coefficient: 1.0

Rhodopsin
type: ProteinReference
xref: uniprot F7F2J1 54
xref: PTHR24240:SF15
organism: Monodelphis domestica

uniprot P51489 64
type: UnificationXref
id: P51489
db: uniprot

Gtalpha s39 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gtalpha
stoichiometric coefficient: 1.0

uniprot H2Q9G5 71
type: UnificationXref
id: H2Q9G5
db: uniprot

uniprot F6ZIZ9 215
type: UnificationXref
id: F6ZIZ9
db: uniprot

PARTICIPANT STOICHIOMETRY r41 447
type: Stoichiometry
physical entity: Complex (Ligand/Rhodopsin)
stoichiometric coefficient: 1.0

Phosphodiesterase
type: ProteinReference
evidence: Evidence 326
xref: uniprot D3Z8C9 325
xref: PTHR11347:SF115
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r41 443
type: Stoichiometry
physical entity: Complex (Rhodopsin/Gtalpha/ Gbeta/Ggamma/ Ligand)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r41 444
type: Stoichiometry
physical entity: Complex (Gbeta/Ggamma)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r41 445
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot F7GI54 120
type: UnificationXref
id: F7GI54
db: uniprot

PARTICIPANT STOICHIOMETRY r41 446
type: Stoichiometry
physical entity: Gtalpha
stoichiometric coefficient: 1.0

uniprot P63078 143
type: UnificationXref
id: P63078
db: uniprot

PARTICIPANT STOICHIOMETRY r41 442
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot P02599 292
type: UnificationXref
id: P02599
db: uniprot

uniprot J9P1Y8 77
type: UnificationXref
id: J9P1Y8
db: uniprot

Arrestin
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q90WX6 352
type: UnificationXref
id: Q90WX6
db: uniprot

Putative calmodulin
type: ProteinReference
xref: PTHR23050:SF245
xref: uniprot A0A0D1DU81 261
organism: Ustilago maydis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Recoverin-RIGHT__Recoverin-_r55
controller: Ca2+

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6TFY2 105
xref: PTHR13809:SF21
organism: Macaca mulatta

uniprot Q7QGY7 308
type: UnificationXref
id: Q7QGY7
db: uniprot

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__Rhodopsin_kinase-RIGHT__Rhodopsin_kinase-_r54
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 463
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 462
left: Rhodopsin kinase
interaction type: STATE_TRANSITION
right: Rhodopsin kinase

uniprot E2RHY4 68
type: UnificationXref
id: E2RHY4
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 36

G protein subunit alpha transducin 1
type: ProteinReference
xref: uniprot D3ZSS5 346
xref: PTHR10218:SF67
organism: Rattus norvegicus

uniprot P62152 299
type: UnificationXref
id: P62152
db: uniprot

uniprot A7SCT6 266
type: UnificationXref
id: A7SCT6
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 11

uniprot F7EBQ5 14
type: UnificationXref
id: F7EBQ5
db: uniprot

uniprot P15409 61
type: UnificationXref
id: P15409
db: uniprot

uniprot P0DP28 294
type: UnificationXref
id: P0DP28
db: uniprot

RGS9
type: Protein
entity reference: RGS9
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa19 372
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Recoverin
type: ProteinReference
xref: P00756
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.Recoverin
comment: ENTITY_REFERENCE_NOTES=Long Name: Recoverin Synonym: Synonym not specified Accession: P00756
member entity reference: RCVRN isoform 1
member entity reference: Recoverin
member entity reference: Cancer-associated retinopathy protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63078 143
xref: PTHR13809:SF19
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 142
xref: PTHR13809:SF19
organism: Rattus norvegicus

Calmodulin
type: ProteinReference
xref: PTHR23050:SF245
xref: uniprot P02599 292
organism: Dictyostelium discoideum

Opsin Rh6
type: ProteinReference
xref: uniprot O01668 56
xref: PTHR24240:SF85
organism: Drosophila melanogaster

Gbeta s22 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Rhodopsin-_Complex__Gtalpha_Gbeta__Ggamma_-RIGHT__Complex__Rhodopsin_Gtalpha__Gbeta_Ggamma_-_r3
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 450
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 449
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 448
left: Rhodopsin
left: Complex (Gtalpha/Gbeta/ Ggamma)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Rhodopsin/Gtalpha/ Gbeta/Ggamma)

uniprot P35913 342
type: UnificationXref
id: P35913
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF26
xref: uniprot D4AAI1 91
organism: Rattus norvegicus

uniprot H2QFK0 18
type: UnificationXref
id: H2QFK0
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__PDEalphabeta-_PDEgamma-RIGHT__Complex__PDEalphabeta_PDEgamma_-_r49
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 420
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 421
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 422
left: PDEgamma
left: PDEalphabeta
interaction type: HETERODIMER_ASSOCIATION
right: Complex (PDEalphabeta/PDEgamma)

uniprot Q9WVL4 87
type: UnificationXref
id: Q9WVL4
db: uniprot

uniprot P08099 59
type: UnificationXref
id: P08099
db: uniprot

Cyclic nucleotide-gated channel beta 1
type: ProteinReference
xref: uniprot F1LQB8 177
xref: PTHR45638:SF16
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 231
xref: PTHR19850:SF27
organism: Rattus norvegicus

Recoverin
type: ProteinReference
xref: PTHR23055:SF20
xref: uniprot P35243 318
organism: Homo sapiens

uniprot Q15KE4 154
type: UnificationXref
id: Q15KE4
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 230
organism: Rattus norvegicus

uniprot G3V8K2 122
type: UnificationXref
id: G3V8K2
db: uniprot

PTHR11347:SF115
type: RelationshipXref
id: PTHR11347:SF115
db: PANTHER Family
relationship type: By Homology

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
type: ProteinReference
evidence: Evidence 343
xref: uniprot P35913 342
xref: PTHR11347:SF73
organism: Homo sapiens

uniprot F1MYW8 100
type: UnificationXref
id: F1MYW8
db: uniprot

PTHR24355:SF11
type: RelationshipXref
id: PTHR24355:SF11
db: PANTHER Family
relationship type: By Homology

Complex (Gtalpha/Gbeta/ Ggamma)
type: Complex
component stoichiometry: Ggamma s19 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gtalpha s16 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s17 sa15 STOICHIOMETRY ID COMPLEX
component: Gtalpha
component: Gbeta
component: Ggamma
feature: COMPLEX BINDING FEATURE s23 a17 383
feature: COMPLEX BINDING FEATURE s23 a17 385
feature: COMPLEX BINDING FEATURE s23 a17 387
cellular location: cytosol

Cyclic nucleotide-gated channel rod photoreceptor subunit alpha
type: ProteinReference
xref: uniprot Q90980 191
xref: PTHR45638:SF9
organism: Gallus gallus

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 216
organism: Ornithorhynchus anatinus

uniprot D3Z8C9 325
type: UnificationXref
id: D3Z8C9
db: uniprot

Complex (Rhodopsin/Gtalpha/ Gbeta/Ggamma/ Ligand)
type: Complex
component stoichiometry: Rhodopsin s20 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s22 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s24 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ligand s26 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gtalpha s21 sa4 STOICHIOMETRY ID COMPLEX
component: Gtalpha
component: Ggamma
component: Rhodopsin
component: Gbeta
component: Ligand
feature: COMPLEX BINDING FEATURE s5 a5 363
feature: ACTIVE 47
feature: COMPLEX BINDING FEATURE s5 a5 369
feature: COMPLEX BINDING FEATURE s5 a5 367
feature: COMPLEX BINDING FEATURE s5 a5 365
feature: COMPLEX BINDING FEATURE s5 a5 361
cellular location: cytosol

uniprot O14775 72
type: UnificationXref
id: O14775
db: uniprot

TRANSPORT_LEFT__Na_PLUS_-RIGHT__Na_PLUS_-_r52
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 411
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 412
left: Na+
interaction type: TRANSPORT
right: Na+

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 245
organism: Danio rerio

uniprot P29973 182
type: UnificationXref
id: P29973
db: uniprot

uniprot P18851 222
type: UnificationXref
id: P18851
db: uniprot

PTHR23050:SF385
type: RelationshipXref
id: PTHR23050:SF385
db: PANTHER Family
relationship type: By Homology

uniprot Q5ZJ03 158
type: UnificationXref
id: Q5ZJ03
db: uniprot

PKA
type: Protein
entity reference: PKA
feature: ACTIVE 47
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6Q1E0 103
type: UnificationXref
id: F6Q1E0
db: uniprot

ncbitaxon 214684 244
type: UnificationXref
id: 214684
db: ncbitaxon

PTHR23050:SF381
type: RelationshipXref
id: PTHR23050:SF381
db: PANTHER Family
relationship type: By Homology

uniprot F7D7P2 288
type: UnificationXref
id: F7D7P2
db: uniprot

PTHR23050:SF383
type: RelationshipXref
id: PTHR23050:SF383
db: PANTHER Family
relationship type: By Homology

Cyclic nucleotide gated channel beta 3
type: ProteinReference
xref: PTHR45638:SF8
xref: uniprot H2QWE1 181
organism: Pan troglodytes

Gbeta s3 sa81 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

uniprot F6W037 331
type: UnificationXref
id: F6W037
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 208

PTHR23050:SF389
type: RelationshipXref
id: PTHR23050:SF389
db: PANTHER Family
relationship type: By Homology

uniprot J9NXY2 290
type: UnificationXref
id: J9NXY2
db: uniprot

uniprot P22694 34
type: UnificationXref
id: P22694
db: uniprot

uniprot F5HH30 210
type: UnificationXref
id: F5HH30
db: uniprot

Rhodopsin
type: ProteinReference
xref: uniprot P08100 60
xref: PTHR24240:SF15
organism: Homo sapiens

uniprot A7RPN8 265
type: UnificationXref
id: A7RPN8
db: uniprot

PARTICIPANT STOICHIOMETRY r54 462
type: Stoichiometry
physical entity: Rhodopsin kinase
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__cGMP-RIGHT__5_GMP-_r50
controller: PDEalphabeta

Guanine nucleotide-binding protein G(t) subunit alpha-1
type: ProteinReference
xref: uniprot Q28300 351
xref: PTHR10218:SF67
organism: Canis lupus familiaris

uniprot E9FUX0 206
type: UnificationXref
id: E9FUX0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6T2A6 284
xref: PTHR23050:SF245
organism: Ciona intestinalis

uniprot F6XHP0 109
type: UnificationXref
id: F6XHP0
db: uniprot

PARTICIPANT STOICHIOMETRY r54 463
type: Stoichiometry
physical entity: Rhodopsin kinase
stoichiometric coefficient: 1.0

uniprot A5PKD6 197
type: UnificationXref
id: A5PKD6
db: uniprot

uniprot A0A2I3TWX3 75
type: UnificationXref
id: A0A2I3TWX3
db: uniprot

uniprot P63212 146
type: UnificationXref
id: P63212
db: uniprot

PARTICIPANT STOICHIOMETRY r46 430
type: Stoichiometry
physical entity: Complex (PDEalphabeta/PDEgamma)
stoichiometric coefficient: 1.0

Rhodopsin kinase
type: Protein
entity reference: Rhodopsin kinase
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PKA
type: ProteinReference
xref: P00746
standard name: Protein kinase A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein kinase A Synonym: Synonym not specified Accession: P00746
comment: ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.PKA
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha isoform 1
member entity reference: AGAP001384-PA
member entity reference: cAMP-dependent protein kinase catalytic subunit beta
member entity reference: Uncharacterized protein
member entity reference: cAMP-dependent protein kinase catalytic subunit gamma
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha
member entity reference: PRKACG isoform 1
member entity reference: cAMP-dependent protein kinase catalytic subunit beta isoform 1
member entity reference: Protein kinase cAMP-activated catalytic subunit beta
member entity reference: cAMP-dependent protein kinase, catalytic subunit-like
member entity reference: cAMP-dependent protein kinase catalytic subunit 1
member entity reference: PRKACB isoform 3
member entity reference: cAMP-dependent protein kinase catalytic subunit
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta
member entity reference: Protein kinase cAMP-activated catalytic subunit alpha
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b

uniprot H2Q0S8 320
type: UnificationXref
id: H2Q0S8
db: uniprot

Ggamma
type: ProteinReference
xref: P00751
standard name: G protein gamma subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.G_gamma_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
member entity reference: Guanine nucleotide-binding protein G(T) subunit gamma-T1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
member entity reference: G protein subunit gamma 13
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
member entity reference: G protein subunit gamma 5
member entity reference: Guanine nucleotide binding protein 13, gamma-like

ncbitaxon 5786 208
type: UnificationXref
id: 5786
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r46 431
type: Stoichiometry
physical entity: Gtalpha
stoichiometric coefficient: 1.0

uniprot Q7PXF7 43
type: UnificationXref
id: Q7PXF7
db: uniprot

PARTICIPANT STOICHIOMETRY r46 432
type: Stoichiometry
physical entity: Complex (PDEalphabeta/PDEgamma/ Gtalpha)
stoichiometric coefficient: 1.0

Phosducin
type: Protein
entity reference: Phosducin
feature: Phosducin s145 a180 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot K7AE17 130
type: UnificationXref
id: K7AE17
db: uniprot

uniprot F7ES96 116
type: UnificationXref
id: F7ES96
db: uniprot

Guanine nucleotide-binding protein (G protein), beta 5
type: ProteinReference
xref: PTHR19850:SF36
xref: uniprot F7EBE7 69
organism: Xenopus tropicalis

uniprot P17612 31
type: UnificationXref
id: P17612
db: uniprot

Putative calmodulin
type: ProteinReference
xref: uniprot Q4QHT2 303
xref: PTHR23050:SF245
organism: Leishmania major

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P59768 141
xref: PTHR13809:SF25
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot F6V461 106
organism: Ornithorhynchus anatinus

uniprot P62874 235
type: UnificationXref
id: P62874
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 241

Gtalpha
type: Protein
entity reference: Gtalpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa4 364
feature: Gtalpha s21 sa4 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6XII5 110
type: UnificationXref
id: F6XII5
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF28
xref: uniprot Q6PBR4 164
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DGZ5 163
xref: PTHR13809:SF8
organism: Danio rerio

Protein kinase, cAMP-dependent, catalytic, beta
type: ProteinReference
xref: uniprot Q3ZB92 39
xref: PTHR24353:SF116
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF9
xref: uniprot J9P702 129
organism: Canis lupus familiaris

uniprot A3KMS9 3
type: UnificationXref
id: A3KMS9
db: uniprot

Rhodopsin
type: ProteinReference
xref: P00747
comment: ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.RECEPTOR.Rhodopsin
comment: ENTITY_REFERENCE_NOTES=Long Name: Rhodopsin Synonym: GiPCR Accession: P00747
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: AGAP001161-PA
member entity reference: Rhodopsin
member entity reference: Opsin Rh2
member entity reference: AGAP001162-PA
member entity reference: AGAP002462-PA
member entity reference: AGAP012982-PA
member entity reference: Opsin Rh6
member entity reference: Opsin Rh1
member entity reference: AGAP013149-PA

Complex (Ligand/Rhodopsin)
type: Complex
component stoichiometry: Rhodopsin s9 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ligand s7 sa1 STOICHIOMETRY ID COMPLEX
component: Rhodopsin
component: Ligand
feature: ACTIVE 47
feature: COMPLEX BINDING FEATURE s1 a1 409
feature: COMPLEX BINDING FEATURE s1 a1 407
cellular location: cytosol

Calmodulin-1
type: ProteinReference
xref: PTHR23050:SF438
xref: uniprot Q0JNS6 301
organism: Oryza sativa

Phosducin
type: ProteinReference
xref: PTHR46052:SF3
xref: uniprot O77560 321
organism: Canis lupus familiaris

Rhodopsin s83 a33 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q9UBI6 172
type: UnificationXref
id: Q9UBI6
db: uniprot

Pde6g protein
type: ProteinReference
xref: uniprot Q7ZVI5 259
organism: Danio rerio

uniprot P20941 322
type: UnificationXref
id: P20941
db: uniprot

STATE_TRANSITION_LEFT__cGMP_gated_ion_channel-RIGHT__cGMP_gated_ion_channel-_r51
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 416
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 417
left: cGMP-gated ion channel
interaction type: STATE_TRANSITION
right: cGMP-gated ion channel

eco ECO:0000304 253
type: UnificationXref
id: ECO:0000304
db: eco

Calmodulin-like protein 3
type: ProteinReference
xref: PTHR23050:SF389
xref: uniprot P27482 296
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR45638:SF9
xref: uniprot A0A1D5QR46 175
organism: Macaca mulatta

Gbeta5L s34 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta5L
stoichiometric coefficient: 1.0

ncbitaxon 6238 8
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot Q803H5 246
type: UnificationXref
id: Q803H5
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot F7FXA9 217
organism: Macaca mulatta

ncbitaxon 7739 203
type: UnificationXref
id: 7739
db: ncbitaxon

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot P29387 224
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF9
xref: uniprot H2QZN8 128
organism: Pan troglodytes

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 242
xref: PTHR19850:SF27
organism: Danio rerio

Ca2+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 223

Uncharacterized protein
type: ProteinReference
xref: uniprot W4YPT6 312
xref: PTHR23050:SF245
organism: Strongylocentrotus purpuratus

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 30

uniprot P62871 232
type: UnificationXref
id: P62871
db: uniprot

Gbeta5L
type: Protein
entity reference: Gbeta5L
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa20 374
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(T) subunit gamma-T1
type: ProteinReference
xref: uniprot Q61012 159
xref: PTHR13809:SF26
organism: Mus musculus

uniprot P05131 26
type: UnificationXref
id: P05131
db: uniprot

RGS9 isoform 3
type: ProteinReference
xref: PTHR45746:SF1
xref: uniprot A0A2I3TWX3 75
organism: Pan troglodytes

uniprot Q9JJZ8 193
type: UnificationXref
id: Q9JJZ8
db: uniprot

DISSOCIATION_LEFT__GTP-_Complex__Rhodopsin_Gtalpha__Gbeta_Ggamma__Ligand_-RIGHT__Complex__Gbeta_Ggamma_-_GDP-_Gtalpha-_Complex__Ligand_Rhodopsin_-_r41
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 445
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 446
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 442
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 443
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 447
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 444
left: Complex (Rhodopsin/Gtalpha/ Gbeta/Ggamma/ Ligand)
left: GTP
interaction type: DISSOCIATION
right: Complex (Gbeta/Ggamma)
right: Complex (Ligand/Rhodopsin)
right: Gtalpha
right: GDP

uniprot P59768 141
type: UnificationXref
id: P59768
db: uniprot

Calmodulin
type: ProteinReference
xref: PTHR23050:SF245
xref: uniprot B3RJX8 273
organism: Trichoplax adhaerens

uniprot P17343 221
type: UnificationXref
id: P17343
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 160
xref: PTHR13809:SF8
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: PTHR13809:SF28
xref: uniprot Q61017 161
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
evidence: Evidence 250
xref: PTHR12122:SF4
xref: uniprot F6ZK66 249
organism: Ornithorhynchus anatinus

uniprot F1PJE5 101
type: UnificationXref
id: F1PJE5
db: uniprot

STATE_TRANSITION_LEFT__ATP-_Complex__Ligand_Rhodopsin_-RIGHT__Rhodopsin-_ADP-_r43
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 438
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 441
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 439
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 440
left: Complex (Ligand/Rhodopsin)
left: ATP
interaction type: STATE_TRANSITION
right: Rhodopsin
right: ADP

uniprot H2Q3W7 126
type: UnificationXref
id: H2Q3W7
db: uniprot

Ggamma s6 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

uniprot Q9UK08 173
type: UnificationXref
id: Q9UK08
db: uniprot

cGMP-gated ion channel
type: ProteinReference
xref: P00752
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES=Long Name: cGMP-gated ion channel Synonym: Synonym not specified Accession: P00752
comment: ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.ION_CHANNEL.cGMP_minus_gated_br_ion_space_channel
member entity reference: cGMP-gated cation channel alpha-1
member entity reference: Uncharacterized protein
member entity reference: Cyclic nucleotide gated channel alpha 3, isoform CRA_a
member entity reference: Cyclic nucleotide-gated cation channel beta-1
member entity reference: Cyclic nucleotide-gated cation channel beta-3
member entity reference: Cyclic nucleotide-gated cation channel alpha-3
member entity reference: CNGA3 isoform 3
member entity reference: Cyclic nucleotide-gated channel rod photoreceptor subunit alpha
member entity reference: Cyclic nucleotide-gated channel beta 1
member entity reference: Cyclic nucleotide gated channel beta 3

Recoverin
type: ProteinReference
xref: PTHR23055:SF20
xref: uniprot P34057 317
organism: Mus musculus

uniprot A4IGZ2 89
type: UnificationXref
id: A4IGZ2
db: uniprot

uniprot F1A421 207
type: UnificationXref
id: F1A421
db: uniprot

ncbitaxon 7719 285
type: UnificationXref
id: 7719
db: ncbitaxon

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
type: ProteinReference
xref: PTHR12122:SF4
xref: uniprot P04972 252
organism: Bos taurus

Recoverin
type: ProteinReference
xref: PTHR23055:SF20
xref: uniprot P21457 316
organism: Bos taurus

Phosphodiesterase
type: ProteinReference
evidence: Evidence 328
xref: uniprot D3ZDI8 327
xref: PTHR11347:SF73
organism: Rattus norvegicus

Evidence 255
type: Evidence
evidence code: TAS
comment: SPACC P09174

uniprot C3ZEW2 278
type: UnificationXref
id: C3ZEW2
db: uniprot

Evidence 250
type: Evidence
evidence code: ISS
comment: SPACC P54827

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 13

cGMP-gated cation channel alpha-1
type: ProteinReference
xref: uniprot Q28279 188
xref: PTHR45638:SF9
organism: Canis lupus familiaris

uniprot P36408 226
type: UnificationXref
id: P36408
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rhodopsin_kinase-RIGHT__Rhodopsin_kinase-_r54
controller: Calmodulin

Evidence 258
type: Evidence
evidence code: TAS
comment: SPACC P54827

Rhodopsin
type: Protein
entity reference: Rhodopsin
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa2 410
feature: Rhodopsin s9 sa2 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q0JNS6 301
type: UnificationXref
id: Q0JNS6
db: uniprot

TRIGGER
type: RelationshipTypeVocabulary

Uncharacterized protein
type: ProteinReference
xref: uniprot J9NWQ5 289
xref: PTHR23050:SF427
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: PTHR13809:SF28
xref: uniprot O14610 132
organism: Homo sapiens

DISSOCIATION_LEFT__Complex__PDEalphabeta_PDEgamma__Gtalpha_-RIGHT__Complex__PDEgamma_Gtalpha_-_PDEalphabeta-_r47
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 429
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 428
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 427
left: Complex (PDEalphabeta/PDEgamma/ Gtalpha)
interaction type: DISSOCIATION
right: PDEalphabeta
right: Complex (PDEgamma/Gtalpha)

5-GMP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot E2R2S8 205
type: UnificationXref
id: E2R2S8
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P49177 228
organism: Arabidopsis thaliana

cAMP-dependent protein kinase, catalytic subunit-like
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q7JP68 41
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR15936:SF2
xref: uniprot F6Q1E0 103
organism: Macaca mulatta

uniprot F1LQB8 177
type: UnificationXref
id: F1LQB8
db: uniprot

uniprot F6YZA3 112
type: UnificationXref
id: F6YZA3
db: uniprot

PARTICIPANT STOICHIOMETRY re22 454
type: Stoichiometry
physical entity: Complex (Gbeta/Ggamma)
stoichiometric coefficient: 1.0

PDEalphabeta
type: Protein
entity reference: PDEalphabeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa23 390
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P43425 136
type: UnificationXref
id: P43425
db: uniprot

PARTICIPANT STOICHIOMETRY re22 455
type: Stoichiometry
physical entity: Complex (Gbeta/Ggamma)
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 220
xref: PTHR19850:SF27
organism: Bos taurus

uniprot F6W548 108
type: UnificationXref
id: F6W548
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha transducing activity polypeptide 1
type: ProteinReference
xref: uniprot Q90WX6 352
xref: PTHR10218:SF67
organism: Danio rerio

uniprot P62880 237
type: UnificationXref
id: P62880
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T7 70
xref: PTHR19850:SF36
organism: Macaca mulatta

uniprot P63214 148
type: UnificationXref
id: P63214
db: uniprot

uniprot P50150 137
type: UnificationXref
id: P50150
db: uniprot

Ligand s26 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ligand
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot F5HH30 210
organism: Neurospora crassa

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P43425 136
xref: PTHR13809:SF8
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QUX9 127
xref: PTHR13809:SF26
organism: Pan troglodytes

ncbitaxon 9258 50
type: UnificationXref
id: 9258
db: ncbitaxon

Ligand
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa1 408
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IGZ2 89
xref: PTHR13809:SF11
organism: Xenopus tropicalis

ncbitaxon 9615 46
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot Q09639 83
type: UnificationXref
id: Q09639
db: uniprot

Opsin Rh2
type: ProteinReference
xref: PTHR45695:SF9
xref: uniprot P08099 59
organism: Drosophila melanogaster

uniprot P62149 298
type: UnificationXref
id: P62149
db: uniprot

PARTICIPANT STOICHIOMETRY r49 420
type: Stoichiometry
physical entity: PDEalphabeta
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: PTHR13809:SF9
xref: uniprot Q28024 155
organism: Bos taurus

uniprot P54827 257
type: UnificationXref
id: P54827
db: uniprot

ncbitaxon 7668 311
type: UnificationXref
id: 7668
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XWE8 111
xref: PTHR13809:SF8
organism: Monodelphis domestica

PTHR13809:SF19
type: RelationshipXref
id: PTHR13809:SF19
db: PANTHER Family
relationship type: By Homology

uniprot F1MSE1 319
type: UnificationXref
id: F1MSE1
db: uniprot

ncbitaxon 6669 11
type: UnificationXref
id: 6669
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r49 422
type: Stoichiometry
physical entity: Complex (PDEalphabeta/PDEgamma)
stoichiometric coefficient: 1.0

uniprot F7CY56 287
type: UnificationXref
id: F7CY56
db: uniprot

PARTICIPANT STOICHIOMETRY r49 421
type: Stoichiometry
physical entity: PDEgamma
stoichiometric coefficient: 1.0

Rhodopsin s15 a19 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR13809:SF11
type: RelationshipXref
id: PTHR13809:SF11
db: PANTHER Family
relationship type: By Homology

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa8 358
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q10282 238
type: UnificationXref
id: Q10282
db: uniprot

uniprot A4ZIS8 49
type: UnificationXref
id: A4ZIS8
db: uniprot

Gtalpha
type: Protein
entity reference: Gtalpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa14 384
feature: Gtalpha s16 sa14 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

eco ECO:0000501 73
type: UnificationXref
id: ECO:0000501
db: eco

Bos taurus
type: BioSource
xref: ncbitaxon 9913 24

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
type: ProteinReference
xref: uniprot P23439 337
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CLC0 286
xref: PTHR23050:SF427
organism: Monodelphis domestica

Phosducin
type: ProteinReference
xref: PTHR46052:SF3
xref: uniprot P20941 322
organism: Homo sapiens

Phosducin
type: ProteinReference
xref: PTHR46052:SF3
xref: uniprot P20942 323
organism: Rattus norvegicus

PTHR15936:SF2
type: RelationshipXref
id: PTHR15936:SF2
db: PANTHER Family
relationship type: By Homology

uniprot E1BK80 329
type: UnificationXref
id: E1BK80
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 50

PTHR13809:SF28
type: RelationshipXref
id: PTHR13809:SF28
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q3W7 126
xref: PTHR13809:SF11
organism: Pan troglodytes

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
type: ProteinReference
evidence: Evidence 328
xref: PTHR11347:SF73
xref: uniprot P23440 338
organism: Mus musculus

PTHR13809:SF25
type: RelationshipXref
id: PTHR13809:SF25
db: PANTHER Family
relationship type: By Homology

PTHR13809:SF26
type: RelationshipXref
id: PTHR13809:SF26
db: PANTHER Family
relationship type: By Homology

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 73

ncbitaxon 665079 199
type: UnificationXref
id: 665079
db: ncbitaxon

Guanine nucleotide binding protein 13, gamma-like
type: ProteinReference
xref: PTHR15936:SF2
xref: uniprot E1B8Q3 92
organism: Bos taurus

uniprot P11017 220
type: UnificationXref
id: P11017
db: uniprot

PTHR13809:SF21
type: RelationshipXref
id: PTHR13809:SF21
db: PANTHER Family
relationship type: By Homology

uniprot E1B8Q3 92
type: UnificationXref
id: E1B8Q3
db: uniprot

Gbeta s29 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa12 380
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P30671 135
xref: PTHR13809:SF8
organism: Bos taurus

PDEgamma
type: Protein
entity reference: PDEgamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s36 sa22 402
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot O01668 56
type: UnificationXref
id: O01668
db: uniprot

Na+
type: SmallMolecule
comment: SPECIES_TYPE=ION

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 201

Ggamma s24 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

uniprot F6T2A6 284
type: UnificationXref
id: F6T2A6
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot F1A421 207
organism: Dictyostelium purpureum

uniprot H2QC95 315
type: UnificationXref
id: H2QC95
db: uniprot

uniprot E1BW98 204
type: UnificationXref
id: E1BW98
db: uniprot

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
type: ProteinReference
evidence: Evidence 340
xref: uniprot P27664 339
xref: PTHR11347:SF115
organism: Mus musculus

Calmodulin-2
type: ProteinReference
xref: PTHR23050:SF385
xref: uniprot Q6F332 306
organism: Oryza sativa

cAMP-dependent protein kinase catalytic subunit 1
type: ProteinReference
xref: uniprot P12370 29
xref: PTHR24353:SF117
organism: Drosophila melanogaster

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 46

ncbitaxon 6945 201
type: UnificationXref
id: 6945
db: ncbitaxon

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 219
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot F7G7I9 119
organism: Ornithorhynchus anatinus

uniprot Q28300 351
type: UnificationXref
id: Q28300
db: uniprot

CNGA3 isoform 3
type: ProteinReference
xref: PTHR45638:SF6
xref: uniprot A0A2I3STD9 176
organism: Pan troglodytes

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Complex__Rhodopsin_Gtalpha__Gbeta_Ggamma_-RIGHT__Complex__Rhodopsin_Gtalpha__Gbeta_Ggamma__Ligand_-_r44
control type: ACTIVATION
controller: Photon

uniprot A4IFL6 88
type: UnificationXref
id: A4IFL6
db: uniprot

uniprot Q4QHT2 303
type: UnificationXref
id: Q4QHT2
db: uniprot

Gtalpha
type: Protein
entity reference: Gtalpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s41 sa27 398
feature: ACTIVE 47
feature: Gtalpha s41 sa27 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

G protein-coupled receptor kinase 2
type: ProteinReference
xref: uniprot Q09639 83
organism: Caenorhabditis elegans

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 94

AGAP013149-PA
type: ProteinReference
xref: PTHR24240:SF85
xref: uniprot F5HMX8 51
organism: Anopheles gambiae

uniprot F7BB02 114
type: UnificationXref
id: F7BB02
db: uniprot

cGMP-gated ion channel
type: Protein
entity reference: cGMP-gated ion channel
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot E9H5Z2 282
type: UnificationXref
id: E9H5Z2
db: uniprot

PARTICIPANT STOICHIOMETRY r48 425
type: Stoichiometry
physical entity: P
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r48 424
type: Stoichiometry
physical entity: Gtalpha
stoichiometric coefficient: 1.0

uniprot F7G7I9 119
type: UnificationXref
id: F7G7I9
db: uniprot

PARTICIPANT STOICHIOMETRY r48 423
type: Stoichiometry
physical entity: Complex (PDEgamma/Gtalpha)
stoichiometric coefficient: 1.0

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa9 360
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7GI54 120
xref: PTHR13809:SF11
organism: Monodelphis domestica

uniprot Q9QW08 324
type: UnificationXref
id: Q9QW08
db: uniprot

PARTICIPANT STOICHIOMETRY r48 426
type: Stoichiometry
physical entity: PDEgamma
stoichiometric coefficient: 1.0

PTHR23055:SF20
type: RelationshipXref
id: PTHR23055:SF20
db: PANTHER Family
relationship type: By Homology

Cyclic nucleotide gated channel alpha 3, isoform CRA_a
type: ProteinReference
xref: PTHR45638:SF6
xref: uniprot Q9ER33 192
organism: Rattus norvegicus

uniprot Q7JP68 41
type: UnificationXref
id: Q7JP68
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45638:SF6
xref: uniprot F7GZN6 179
organism: Macaca mulatta

uniprot Q9JMF3 169
type: UnificationXref
id: Q9JMF3
db: uniprot

cGMP-gated ion channel
type: Protein
entity reference: cGMP-gated ion channel
feature: ACTIVE 47
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5KI86 243
organism: Cryptococcus neoformans

uniprot Q6DBV8 40
type: UnificationXref
id: Q6DBV8
db: uniprot

Guanine nucleotide binding protein, beta subunit
type: ProteinReference
xref: uniprot E9FUX0 206
organism: Daphnia pulex

Cyclic nucleotide-gated cation channel alpha-3
type: ProteinReference
xref: uniprot Q29441 189
xref: PTHR45638:SF6
organism: Bos taurus

Rhodopsin
type: ProteinReference
xref: PTHR24240:SF15
xref: uniprot P32308 62
organism: Canis lupus familiaris

eco ECO:0000305 170
type: UnificationXref
id: ECO:0000305
db: eco

Gtalpha s41 sa27 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P62873 234
type: UnificationXref
id: P62873
db: uniprot

uniprot F6PGC8 212
type: UnificationXref
id: F6PGC8
db: uniprot

Rhodopsin kinase
type: Protein
entity reference: Rhodopsin kinase
feature: ACTIVE 47
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9606 32
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot E2RGI5 98
type: UnificationXref
id: E2RGI5
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9UBI6 172
xref: PTHR13809:SF9
organism: Homo sapiens

uniprot F7BN33 53
type: UnificationXref
id: F7BN33
db: uniprot

Guanine nucleotide-binding protein G(t) subunit alpha-1
type: ProteinReference
xref: uniprot P11488 349
xref: PTHR10218:SF67
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 213
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 214
xref: PTHR19850:SF27
organism: Monodelphis domestica

THO complex subunit, putative
type: ProteinReference
xref: uniprot B7Q3T6 200
organism: Ixodes scapularis

LOC100124827 protein
type: ProteinReference
xref: uniprot A4IHC2 248
organism: Xenopus tropicalis

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: PTHR24353:SF137
xref: uniprot P22612 33
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XHP0 109
xref: PTHR13809:SF5
organism: Macaca mulatta

RGS9
type: Protein
entity reference: RGS9
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Regulator of G-protein signaling 9
type: ProteinReference
xref: uniprot O75916 79
xref: PTHR45746:SF1
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: PTHR13809:SF9
xref: uniprot Q9DAS9 168
organism: Mus musculus

Regulator of G-protein-signaling 9
type: ProteinReference
xref: uniprot F1MYX4 76
xref: PTHR45746:SF1
organism: Bos taurus

ncbitaxon 284812 239
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot P63211 145
type: UnificationXref
id: P63211
db: uniprot

PARTICIPANT STOICHIOMETRY r52 411
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

Gtalpha
type: Protein
entity reference: Gtalpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa11 378
feature: Gtalpha s28 sa11 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r52 412
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

AGAP001162-PA
type: ProteinReference
xref: PTHR24240:SF85
xref: uniprot A0NH90 48
organism: Anopheles gambiae

uniprot F7F580 118
type: UnificationXref
id: F7F580
db: uniprot

ncbitaxon 7955 4
type: UnificationXref
id: 7955
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR13809:SF52
xref: uniprot F7ASR8 113
organism: Macaca mulatta

AGAP012982-PA
type: ProteinReference
xref: uniprot F5HMY2 52
xref: PTHR24240:SF85
organism: Anopheles gambiae

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 302

uniprot P63219 153
type: UnificationXref
id: P63219
db: uniprot

Gbeta5L
type: Protein
entity reference: Gbeta5L
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

G-protein beta subunit
type: ProteinReference
xref: uniprot Q5BH99 240
organism: Emericella nidulans

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF245
xref: uniprot C3XRD1 275
organism: Branchiostoma floridae

Guanine nucleotide-binding protein G(t) subunit alpha-1
type: ProteinReference
xref: uniprot P04695 348
xref: PTHR10218:SF67
organism: Bos taurus

Protein kinase cAMP-activated catalytic subunit alpha
type: ProteinReference
xref: uniprot H2QFK0 18
xref: PTHR24353:SF82
organism: Pan troglodytes

uniprot Q1XHM0 85
type: UnificationXref
id: Q1XHM0
db: uniprot

Gtalpha
type: ProteinReference
xref: P00760
standard name: Gt protein, alpha subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Gtalpha Synonym: Synonym not specified Accession: P00760
comment: ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.G_sub_t_endsub__alpha_
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein G(t) subunit alpha-1
member entity reference: G protein subunit alpha transducin 1
member entity reference: Guanine nucleotide-binding protein (G protein), alpha transducing activity polypeptide 1

PARTICIPANT STOICHIOMETRY r51 416
type: Stoichiometry
physical entity: cGMP-gated ion channel
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 417
type: Stoichiometry
physical entity: cGMP-gated ion channel
stoichiometric coefficient: 1.0

ACTIVE 47
type: EntityFeature
comment: Active state

Rhodopsin s146 sa10 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 44

uniprot P29974 183
type: UnificationXref
id: P29974
db: uniprot

G protein-coupled receptor kinase
type: ProteinReference
xref: uniprot Q1XHM0 85
xref: PTHR24355:SF11
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 100
xref: PTHR13809:SF19
organism: Bos taurus

uniprot E2R9G5 97
type: UnificationXref
id: E2R9G5
db: uniprot

uniprot O14610 132
type: UnificationXref
id: O14610
db: uniprot

ncbitaxon 367110 211
type: UnificationXref
id: 367110
db: ncbitaxon

Rhodopsin kinase
type: ProteinReference
xref: uniprot Q63651 86
xref: PTHR24355:SF11
organism: Rattus norvegicus

uniprot D3ZLD6 90
type: UnificationXref
id: D3ZLD6
db: uniprot

uniprot P63077 142
type: UnificationXref
id: P63077
db: uniprot

cGMP-gated cation channel alpha-1
type: ProteinReference
xref: PTHR45638:SF9
xref: uniprot Q62927 190
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r43 438
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r43 439
type: Stoichiometry
physical entity: Complex (Ligand/Rhodopsin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 434
type: Stoichiometry
physical entity: Gbeta5L
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 435
type: Stoichiometry
physical entity: Complex (RGS9/Gbeta5L)
stoichiometric coefficient: 1.0

uniprot G3V6G4 314
type: UnificationXref
id: G3V6G4
db: uniprot

PARTICIPANT STOICHIOMETRY r45 433
type: Stoichiometry
physical entity: RGS9
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7BB02 114
xref: PTHR13809:SF8
organism: Macaca mulatta

uniprot H2QNS5 219
type: UnificationXref
id: H2QNS5
db: uniprot

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 246
organism: Danio rerio

Gtalpha s28 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gtalpha
stoichiometric coefficient: 1.0

uniprot P05132 27
type: UnificationXref
id: P05132
db: uniprot

PARTICIPANT STOICHIOMETRY r2 451
type: Stoichiometry
physical entity: Complex (Gbeta/Ggamma)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 452
type: Stoichiometry
physical entity: Gtalpha
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 453
type: Stoichiometry
physical entity: Complex (Gtalpha/Gbeta/ Ggamma)
stoichiometric coefficient: 1.0

DISSOCIATION_LEFT__Complex__PDEgamma_Gtalpha_-RIGHT__Gtalpha-_P-_PDEgamma-_r48
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 425
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 424
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 426
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 423
left: Complex (PDEgamma/Gtalpha)
interaction type: DISSOCIATION
right: P
right: PDEgamma
right: Gtalpha

uniprot P54313 231
type: UnificationXref
id: P54313
db: uniprot

uniprot Q28279 188
type: UnificationXref
id: Q28279
db: uniprot

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 274

STATE_TRANSITION_LEFT__Phosducin-RIGHT__Phosducin-_r57
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 456
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 457
left: Phosducin
interaction type: STATE_TRANSITION
right: Phosducin

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3KRE3 156
xref: PTHR13809:SF6
organism: Rattus norvegicus

Photon
type: PhysicalEntity
comment: SPECIES_TYPE=UNKNOWN

PARTICIPANT STOICHIOMETRY r43 440
type: Stoichiometry
physical entity: Rhodopsin
stoichiometric coefficient: 1.0

uniprot P62881 74
type: UnificationXref
id: P62881
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: PTHR19850:SF36
xref: uniprot E2RHY4 68
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r43 441
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Rhodopsin
type: Protein
entity reference: Rhodopsin
feature: COMPLEX PARTICIPANT BINDING FEATURE s146 sa10 376
feature: Rhodopsin s146 sa10 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Complex__Rhodopsin_Gtalpha__Gbeta_Ggamma_-RIGHT__Complex__Rhodopsin_Gtalpha__Gbeta_Ggamma__Ligand_-_r44
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 436
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 437
left: Complex (Rhodopsin/Gtalpha/ Gbeta/Ggamma)
interaction type: STATE_TRANSITION
right: Complex (Rhodopsin/Gtalpha/ Gbeta/Ggamma/ Ligand)

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot O60262 133
xref: PTHR13809:SF8
organism: Homo sapiens

Complex (PDEalphabeta/PDEgamma)
type: Complex
component stoichiometry: PDEgamma s36 sa22 STOICHIOMETRY ID COMPLEX
component stoichiometry: PDEalphabeta s35 sa21 STOICHIOMETRY ID COMPLEX
component: PDEgamma
component: PDEalphabeta
feature: COMPLEX BINDING FEATURE s125 a156 401
feature: COMPLEX BINDING FEATURE s125 a156 399
cellular location: cytosol

PTHR24353:SF82
type: RelationshipXref
id: PTHR24353:SF82
db: PANTHER Family
relationship type: By Homology

Phosphodiesterase
type: ProteinReference
evidence: Evidence 328
xref: uniprot F7FK36 332
xref: PTHR11347:SF73
organism: Macaca mulatta

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot P68181 37
type: UnificationXref
id: P68181
db: uniprot

uniprot P35243 318
type: UnificationXref
id: P35243
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha transducing activity polypeptide 1
type: ProteinReference
xref: uniprot A4IHG6 345
xref: PTHR10218:SF67
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F1T7 178
xref: PTHR45638:SF8
organism: Macaca mulatta

uniprot H9EQQ4 22
type: UnificationXref
id: H9EQQ4
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF28
xref: uniprot D3ZLD6 90
organism: Rattus norvegicus

Cancer-associated retinopathy protein
type: ProteinReference
xref: PTHR23055:SF20
xref: uniprot F7EG53 313
organism: Macaca mulatta

uniprot P50153 139
type: UnificationXref
id: P50153
db: uniprot

uniprot F1NLV4 209
type: UnificationXref
id: F1NLV4
db: uniprot

ncbitaxon 227321 241
type: UnificationXref
id: 227321
db: ncbitaxon

Recoverin
type: ProteinReference
xref: PTHR23055:SF20
xref: uniprot G3V6G4 314
organism: Rattus norvegicus

uniprot K7E376 131
type: UnificationXref
id: K7E376
db: uniprot

Rhodopsin s20 sa3 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR24353:SF37
type: RelationshipXref
id: PTHR24353:SF37
db: PANTHER Family
relationship type: By Homology

uniprot C3ZSF0 202
type: UnificationXref
id: C3ZSF0
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 239

Predicted protein
type: ProteinReference
xref: PTHR23050:SF245
xref: uniprot A9S9L5 268
organism: Physcomitrella patens

uniprot P50154 140
type: UnificationXref
id: P50154
db: uniprot

Complex (Gbeta/Ggamma)
type: Complex
component stoichiometry: Ggamma s6 sa82 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s3 sa81 STOICHIOMETRY ID COMPLEX
component: Ggamma
component: Gbeta
feature: COMPLEX BINDING FEATURE s10 csa11 353
feature: COMPLEX BINDING FEATURE s10 csa11 355
cellular location: cytosol

Calmodulin
type: ProteinReference
xref: uniprot O16305 291
xref: PTHR23050:SF401
organism: Caenorhabditis elegans

uniprot O77560 321
type: UnificationXref
id: O77560
db: uniprot

eco ECO:0000250 5
type: UnificationXref
id: ECO:0000250
db: eco

uniprot H2PZA6 124
type: UnificationXref
id: H2PZA6
db: uniprot

Phosducin s143 a178 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.932457358931383

Gbeta5L
type: ProteinReference
xref: P00748
standard name: G protein, beta subunit 5L
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.G_beta_5L
comment: ENTITY_REFERENCE_NOTES=Long Name: Gbeta5L Synonym: Synonym not specified Accession: P00748
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein subunit beta-5
member entity reference: Guanine nucleotide-binding protein subunit beta-5a
member entity reference: G protein subunit beta 5
member entity reference: Guanine nucleotide-binding protein (G protein), beta 5

AGAP001161-PA
type: ProteinReference
xref: uniprot Q7PX14 65
xref: PTHR24240:SF85
organism: Anopheles gambiae

uniprot O75916 79
type: UnificationXref
id: O75916
db: uniprot

Rhodopsin
type: ProteinReference
xref: PTHR24240:SF15
xref: uniprot A4ZIS8 49
organism: Ornithorhynchus anatinus

uniprot A0A2I3TUD1 196
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZEW0 277
xref: PTHR23050:SF245
organism: Branchiostoma floridae

DISSOCIATION
type: InteractionVocabulary

PTHR13809:SF52
type: RelationshipXref
id: PTHR13809:SF52
db: PANTHER Family
relationship type: By Homology

uniprot F6SX33 80
type: UnificationXref
id: F6SX33
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF245
xref: uniprot C3ZEW2 278
organism: Branchiostoma floridae

PTHR13809:SF51
type: RelationshipXref
id: PTHR13809:SF51
db: PANTHER Family
relationship type: By Homology

uniprot H2QUX9 127
type: UnificationXref
id: H2QUX9
db: uniprot

Recoverin
type: Protein
entity reference: Recoverin
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Phosducin
type: Protein
entity reference: Phosducin
feature: Phosducin s143 a178 rs1
feature: ACTIVE 47
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P18545 256
type: UnificationXref
id: P18545
db: uniprot

ncbitaxon 10228 274
type: UnificationXref
id: 10228
db: ncbitaxon

Glutamate release
type: Pathway

uniprot F6YFY5 347
type: UnificationXref
id: F6YFY5
db: uniprot

uniprot F2Z3T8 102
type: UnificationXref
id: F2Z3T8
db: uniprot

GNB4 protein
type: ProteinReference
xref: uniprot A5PKD6 197
organism: Bos taurus

uniprot Q9CXP8 167
type: UnificationXref
id: Q9CXP8
db: uniprot

Phosphodiesterase
type: ProteinReference
xref: uniprot F6W037 331
organism: Monodelphis domestica

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 32

HETERODIMER_ASSOCIATION_LEFT__Rhodopsin-_Arrestin-RIGHT__Complex__Rhodopsin_Arrestin_-_r20
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 414
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 415
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 413
left: Arrestin
left: Rhodopsin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Rhodopsin/Arrestin)

Complex (Rhodopsin/Arrestin)
type: Complex
component stoichiometry: Arrestin s14 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: Rhodopsin s147 sa17 STOICHIOMETRY ID COMPLEX
component: Arrestin
component: Rhodopsin
feature: COMPLEX BINDING FEATURE s84 a78 405
feature: COMPLEX BINDING FEATURE s84 a78 403
cellular location: cytosol

uniprot F7FK36 332
type: UnificationXref
id: F7FK36
db: uniprot

uniprot F7ERP8 115
type: UnificationXref
id: F7ERP8
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha isoform 1
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H9EQQ4 22
organism: Macaca mulatta

uniprot P20612 350
type: UnificationXref
id: P20612
db: uniprot

PDEalphabeta
type: ProteinReference
xref: P00759
standard name: Phosphodiesterase alpha/beta subunits
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.PDE_alpha__beta_
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphodiesterase alpha/beta subunits Synonym: Synonym not specified Accession: P00759
member entity reference: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
member entity reference: Phosphodiesterase
member entity reference: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

uniprot Q3ZB92 39
type: UnificationXref
id: Q3ZB92
db: uniprot

Complex (Rhodopsin/Gtalpha/ Gbeta/Ggamma)
type: Complex
component stoichiometry: Rhodopsin s146 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s29 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gtalpha s28 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s30 sa13 STOICHIOMETRY ID COMPLEX
component: Gtalpha
component: Ggamma
component: Rhodopsin
component: Gbeta
feature: COMPLEX BINDING FEATURE s11 a12 375
feature: COMPLEX BINDING FEATURE s11 a12 377
feature: COMPLEX BINDING FEATURE s11 a12 381
feature: COMPLEX BINDING FEATURE s11 a12 379
cellular location: cytosol

uniprot F7ASR8 113
type: UnificationXref
id: F7ASR8
db: uniprot

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 311

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P22694 34
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF245
xref: uniprot C3ZEV9 276
organism: Branchiostoma floridae

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot E1C795 93
organism: Gallus gallus

uniprot E2REK6 279
type: UnificationXref
id: E2REK6
db: uniprot

uniprot Q15835 84
type: UnificationXref
id: Q15835
db: uniprot

uniprot A9S9L5 268
type: UnificationXref
id: A9S9L5
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot R4GKD1 174
organism: Gallus gallus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 116
xref: PTHR13809:SF19
organism: Macaca mulatta

ncbitaxon 9031 94
type: UnificationXref
id: 9031
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NLV4 209
organism: Gallus gallus

uniprot Q6PBR4 164
type: UnificationXref
id: Q6PBR4
db: uniprot

uniprot P33726 341
type: UnificationXref
id: P33726
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V8K2 122
xref: PTHR13809:SF11
organism: Rattus norvegicus

cGMP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

AGAP001384-PA
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot Q7PXF7 43
organism: Anopheles gambiae

uniprot P29387 224
type: UnificationXref
id: P29387
db: uniprot

Complex (Gbeta/Ggamma)
type: Complex
component stoichiometry: Ggamma s6 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s3 sa8 STOICHIOMETRY ID COMPLEX
component: Gbeta
component: Ggamma
feature: COMPLEX BINDING FEATURE s10 a10 357
feature: COMPLEX BINDING FEATURE s10 a10 359
feature: ACTIVE 47
cellular location: cytosol

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa13 382
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

P
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

uniprot A0A2I3STD9 176
type: UnificationXref
id: A0A2I3STD9
db: uniprot

Rhodopsin
type: Protein
entity reference: Rhodopsin
feature: Rhodopsin s15 a19 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
type: ProteinReference
xref: PTHR15936:SF2
xref: uniprot Q9JMF3 169
organism: Mus musculus

Calmodulin-like protein 3
type: ProteinReference
xref: PTHR23050:SF389
xref: uniprot Q5U206 305
organism: Rattus norvegicus

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot A7EDU2 198
organism: Sclerotinia sclerotiorum

PTHR24240:SF85
type: RelationshipXref
id: PTHR24240:SF85
db: PANTHER Family
relationship type: By Homology

RGS9 s33 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RGS9
stoichiometric coefficient: 1.0

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
type: ProteinReference
evidence: Evidence 250
xref: PTHR12122:SF4
xref: uniprot P18545 256
organism: Homo sapiens

G protein subunit alpha transducin 1
type: ProteinReference
xref: uniprot A0A2J8P954 344
xref: PTHR10218:SF67
organism: Pan troglodytes

ncbitaxon 5664 304
type: UnificationXref
id: 5664
db: ncbitaxon

Gtalpha
type: Protein
entity reference: Gtalpha
feature: Gtalpha s39 sa25 rs1
feature: ACTIVE 47
feature: COMPLEX PARTICIPANT BINDING FEATURE s39 sa25 394
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6XWE8 111
type: UnificationXref
id: F6XWE8
db: uniprot

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 227

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot F2Z3T8 102
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa6 368
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7G5L8 333
type: UnificationXref
id: F7G5L8
db: uniprot

uniprot P28327 81
type: UnificationXref
id: P28327
db: uniprot

PTHR10218:SF67
type: RelationshipXref
id: PTHR10218:SF67
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__cGMP-RIGHT__5_GMP-_r50
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 418
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 419
left: cGMP
interaction type: STATE_TRANSITION
right: 5-GMP

Rhodopsin
type: ProteinReference
xref: uniprot P35359 63
xref: PTHR24240:SF15
organism: Danio rerio

uniprot F7EBE7 69
type: UnificationXref
id: F7EBE7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot W4XNQ0 310
xref: PTHR23050:SF414
organism: Strongylocentrotus purpuratus

ncbitaxon 7165 44
type: UnificationXref
id: 7165
db: ncbitaxon

PTHR23050:SF245
type: RelationshipXref
id: PTHR23050:SF245
db: PANTHER Family
relationship type: By Homology

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 170

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 253

Phosphodiesterase
type: ProteinReference
evidence: Evidence 326
xref: uniprot F6SMY5 330
xref: PTHR11347:SF115
organism: Macaca mulatta

uniprot Q6DGZ5 163
type: UnificationXref
id: Q6DGZ5
db: uniprot

Rhodopsin
type: Protein
entity reference: Rhodopsin
feature: Rhodopsin s83 a33 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot K7E376 131
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot Q80SZ7 165
organism: Mus musculus

uniprot A9V8J8 271
type: UnificationXref
id: A9V8J8
db: uniprot

uniprot P0DP23 293
type: UnificationXref
id: P0DP23
db: uniprot

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 264

uniprot Q28181 187
type: UnificationXref
id: Q28181
db: uniprot

PTHR23050:SF427
type: RelationshipXref
id: PTHR23050:SF427
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q90Z40 166
xref: PTHR13809:SF11
organism: Danio rerio

PTHR23050:SF424
type: RelationshipXref
id: PTHR23050:SF424
db: PANTHER Family
relationship type: By Homology

uniprot G3V8Y0 123
type: UnificationXref
id: G3V8Y0
db: uniprot

Rhodopsin
type: ProteinReference
xref: uniprot H2QNC5 55
xref: PTHR24240:SF15
organism: Pan troglodytes

uniprot O54828 78
type: UnificationXref
id: O54828
db: uniprot

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa81 354
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P22612 33
type: UnificationXref
id: P22612
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 215
organism: Macaca mulatta

uniprot F6T0T9 12
type: UnificationXref
id: F6T0T9
db: uniprot

PTHR23050:SF438
type: RelationshipXref
id: PTHR23050:SF438
db: PANTHER Family
relationship type: By Homology

Complex (PDEgamma/Gtalpha)
type: Complex
component stoichiometry: Gtalpha s41 sa27 STOICHIOMETRY ID COMPLEX
component stoichiometry: PDEgamma s40 sa26 STOICHIOMETRY ID COMPLEX
component: PDEgamma
component: Gtalpha
feature: COMPLEX BINDING FEATURE s130 a164 395
feature: COMPLEX BINDING FEATURE s130 a164 397
cellular location: cytosol

Rhodopsin
type: ProteinReference
xref: PTHR24240:SF15
xref: uniprot P02699 57
organism: Bos taurus

Guanine nucleotide-binding protein G(T) subunit gamma-T1
type: ProteinReference
xref: uniprot P02698 134
xref: PTHR13809:SF26
organism: Bos taurus

Recoverin
type: Protein
entity reference: Recoverin
feature: ACTIVE 47
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P27664 339
type: UnificationXref
id: P27664
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7D7P2 288
xref: PTHR23050:SF427
organism: Monodelphis domestica

ncbitaxon 45351 264
type: UnificationXref
id: 45351
db: ncbitaxon

uniprot P29829 225
type: UnificationXref
id: P29829
db: uniprot

uniprot F7FXA9 217
type: UnificationXref
id: F7FXA9
db: uniprot

uniprot P02698 134
type: UnificationXref
id: P02698
db: uniprot

PARTICIPANT STOICHIOMETRY r57 457
type: Stoichiometry
physical entity: Phosducin
stoichiometric coefficient: 1.0

uniprot Q62927 190
type: UnificationXref
id: Q62927
db: uniprot

Rhodopsin s147 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rhodopsin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r57 456
type: Stoichiometry
physical entity: Phosducin
stoichiometric coefficient: 1.0

PTHR23050:SF401
type: RelationshipXref
id: PTHR23050:SF401
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION
type: InteractionVocabulary

cAMP-dependent protein kinase, catalytic subunit-like
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot A8XJQ6 7
organism: Caenorhabditis briggsae

Ggamma s19 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

TRANSPORT
type: InteractionVocabulary

uniprot Q9ER33 192
type: UnificationXref
id: Q9ER33
db: uniprot

uniprot Q802E4 260
type: UnificationXref
id: Q802E4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot F7G4Q0 16
organism: Monodelphis domestica

PDEgamma
type: ProteinReference
xref: P00754
standard name: Phosphodiesterase gamma subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction.PROTEIN.GENERIC.PDE_gamma_
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphodiesterase gamma subunit Synonym: Synonym not specified Accession: P00754
member entity reference: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
member entity reference: Uncharacterized protein
member entity reference: Pde6g protein
member entity reference: LOC100124827 protein
member entity reference: Phosphodiesterase 6 gamma subunit rod form

PDEalphabeta s37 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PDEalphabeta
stoichiometric coefficient: 1.0

PRKACG isoform 1
type: ProteinReference
xref: PTHR24353:SF137
xref: uniprot H2QXB9 20
organism: Pan troglodytes

Phosducin s145 a180 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.932457358931383

ncbitaxon 44689 227
type: UnificationXref
id: 44689
db: ncbitaxon

Calmodulin
type: ProteinReference
xref: PTHR23050:SF424
xref: uniprot Q6PI52 307
organism: Danio rerio

Ggamma s6 sa82 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r55 461
type: Stoichiometry
physical entity: Recoverin
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
evidence: Evidence 250
xref: PTHR12122:SF4
xref: uniprot F7CXV2 251
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r55 460
type: Stoichiometry
physical entity: Recoverin
stoichiometric coefficient: 1.0

uniprot Q5U206 305
type: UnificationXref
id: Q5U206
db: uniprot

uniprot P62157 300
type: UnificationXref
id: P62157
db: uniprot

uniprot Q29441 189
type: UnificationXref
id: Q29441
db: uniprot

uniprot P21457 316
type: UnificationXref
id: P21457
db: uniprot

uniprot F7E427 216
type: UnificationXref
id: F7E427
db: uniprot

PTHR23050:SF414
type: RelationshipXref
id: PTHR23050:SF414
db: PANTHER Family
relationship type: By Homology

uniprot Q9P2W3 171
type: UnificationXref
id: Q9P2W3
db: uniprot

Cyclic nucleotide-gated cation channel beta-3
type: ProteinReference
xref: uniprot Q9NQW8 195
xref: PTHR45638:SF8
organism: Homo sapiens

Phosphodiesterase 6 gamma subunit rod form
type: ProteinReference
xref: uniprot Q802E4 260
organism: Gallus gallus

ncbitaxon 7227 30
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot Q90980 191
type: UnificationXref
id: Q90980
db: uniprot

uniprot F6SMY5 330
type: UnificationXref
id: F6SMY5
db: uniprot

uniprot P63218 152
type: UnificationXref
id: P63218
db: uniprot

Gtalpha
type: Protein
entity reference: Gtalpha
feature: Gtalpha s12 a13 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Leishmania major
type: BioSource
xref: ncbitaxon 5664 304

PDEgamma
type: Protein
entity reference: PDEgamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa24 392
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR46052:SF3
type: RelationshipXref
id: PTHR46052:SF3
db: PANTHER Family
relationship type: By Homology

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

STATE_TRANSITION_LEFT__Complex__Gbeta_Ggamma_-RIGHT__Complex__Gbeta_Ggamma_-_re22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 455
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 454
left: Complex (Gbeta/Ggamma)
interaction type: STATE_TRANSITION
right: Complex (Gbeta/Ggamma)

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF424
xref: uniprot F7CY56 287
organism: Monodelphis domestica

Cyclic nucleotide-gated cation channel beta-1
type: ProteinReference
xref: uniprot Q14028 185
xref: PTHR45638:SF16
organism: Homo sapiens

ncbitaxon 3218 269
type: UnificationXref
id: 3218
db: ncbitaxon

uniprot P04695 348
type: UnificationXref
id: P04695
db: uniprot

uniprot Q90Z40 166
type: UnificationXref
id: Q90Z40
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot F7ERP8 115
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6VPY1 107
xref: PTHR13809:SF25
organism: Ornithorhynchus anatinus

uniprot C3ZEV9 276
type: UnificationXref
id: C3ZEV9
db: uniprot

GTP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P36408 226
organism: Dictyostelium discoideum

Monosiga brevicollis
type: BioSource
xref: ncbitaxon 81824 272

Rhodopsin s9 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rhodopsin
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit beta isoform 1
type: ProteinReference
xref: uniprot F7EBQ5 14
xref: PTHR24353:SF116
organism: Macaca mulatta

uniprot A8WPJ8 267
type: UnificationXref
id: A8WPJ8
db: uniprot