uniprot P62871 362
type: UnificationXref
id: P62871
db: uniprot

uniprot Q7Q6D2 411
type: UnificationXref
id: Q7Q6D2
db: uniprot

PANTHER Pathway P04385 1
type: UnificationXref
id: P04385
db: PANTHER Pathway

uniprot Q9WTQ0 247
type: UnificationXref
id: Q9WTQ0
db: uniprot

PTHR24356:SF303
type: RelationshipXref
id: PTHR24356:SF303
db: PANTHER Family
relationship type: By Homology

uniprot P28867 221
type: UnificationXref
id: P28867
db: uniprot

uniprot Q28024 383
type: UnificationXref
id: Q28024
db: uniprot

GO GO:0005783 2
type: UnificationXref
id: GO:0005783
db: GO

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q5ZJ03 397
organism: Gallus gallus

uniprot A7EDU2 256
type: UnificationXref
id: A7EDU2
db: uniprot

PTHR24356:SF170
type: RelationshipXref
id: PTHR24356:SF170
db: PANTHER Family
relationship type: By Homology

uniprot F7G3J2 313
type: UnificationXref
id: F7G3J2
db: uniprot

uniprot Q63269 168
type: UnificationXref
id: Q63269
db: uniprot

ncbitaxon 39947 113
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot G5EFI8 64
type: UnificationXref
id: G5EFI8
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IFL6 253
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re18 465
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re18 464
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63212 371
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF347
xref: uniprot A8WR64 179
organism: Caenorhabditis briggsae

P04485
type: UnificationXref
id: P04485
db: PANTHER Pathway Component

P04484
type: UnificationXref
id: P04484
db: PANTHER Pathway Component

P04487
type: UnificationXref
id: P04487
db: PANTHER Pathway Component

P04486
type: UnificationXref
id: P04486
db: PANTHER Pathway Component

Mus musculus
type: BioSource
xref: ncbitaxon 10090 25

P04488
type: UnificationXref
id: P04488
db: PANTHER Pathway Component

PTHR24356:SF181
type: RelationshipXref
id: PTHR24356:SF181
db: PANTHER Family
relationship type: By Homology

G Protein s5 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A8X1E0 26
organism: Caenorhabditis briggsae

uniprot A0A2I3TUD1 250
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

Protein kinase C-like 3
type: ProteinReference
xref: PTHR24356:SF303
xref: uniprot Q19266 237
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)
type: ProteinReference
xref: uniprot Q5RKP9 395
xref: PTHR10218:SF328
organism: Danio rerio

uniprot Q10282 380
type: UnificationXref
id: Q10282
db: uniprot

PLC
type: Protein
entity reference: PLC
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 366
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 365
organism: Mus musculus

uniprot E1BQN6 181
type: UnificationXref
id: E1BQN6
db: uniprot

uniprot P26308 342
type: UnificationXref
id: P26308
db: uniprot

G Protein s12 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 363
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 364
organism: Homo sapiens

PTHR24356:SF192
type: RelationshipXref
id: PTHR24356:SF192
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot P62881 368
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 367
organism: Mus musculus

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot Q14643 166
organism: Homo sapiens

H1
type: Protein
entity reference: H1
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa1 444
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=PROTEIN

uniprot H9EU39 204
type: UnificationXref
id: H9EU39
db: uniprot

uniprot C3ZSF0 261
type: UnificationXref
id: C3ZSF0
db: uniprot

PTHR10218:SF316
type: RelationshipXref
id: PTHR10218:SF316
db: PANTHER Family
relationship type: By Homology

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot Q6Z3Y9 112
organism: Oryza sativa

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot Q01970 95
organism: Homo sapiens

PTHR24356:SF193
type: RelationshipXref
id: PTHR24356:SF193
db: PANTHER Family
relationship type: By Homology

uniprot P05126 206
type: UnificationXref
id: P05126
db: uniprot

uniprot F6XWE8 294
type: UnificationXref
id: F6XWE8
db: uniprot

uniprot Q9XWB7 134
type: UnificationXref
id: Q9XWB7
db: uniprot

uniprot A0A2I3RKF6 13
type: UnificationXref
id: A0A2I3RKF6
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 284

uniprot P62881 368
type: UnificationXref
id: P62881
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 362
organism: Bos taurus

Complex (GDP/G-Protein/ H1)
type: Complex
component stoichiometry: H1 s13 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s11 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s12 sa10 STOICHIOMETRY ID COMPLEX
component: H1
component: G-Protein
component: GDP
feature: COMPLEX BINDING FEATURE s112 a96 427
feature: COMPLEX BINDING FEATURE s112 a96 429
feature: COMPLEX BINDING FEATURE s112 a96 425
cellular location: Smooth Muscle trachea, ileum, uterus c3

PIP2
type: SmallMolecule
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Complex (H1/histamine)
type: Complex
component stoichiometry: H1 s2 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: histamine s3 sa2 STOICHIOMETRY ID COMPLEX
component: histamine
component: H1
feature: COMPLEX BINDING FEATURE s9 a13 443
feature: COMPLEX BINDING FEATURE s9 a13 445
cellular location: Smooth Muscle trachea, ileum, uterus c3

uniprot P63318 225
type: UnificationXref
id: P63318
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F6ZC55 56
organism: Monodelphis domestica

uniprot P05771 210
type: UnificationXref
id: P05771
db: uniprot

PTHR10218:SF328
type: RelationshipXref
id: PTHR10218:SF328
db: PANTHER Family
relationship type: By Homology

PTHR10218:SF329
type: RelationshipXref
id: PTHR10218:SF329
db: PANTHER Family
relationship type: By Homology

IP3R
type: Protein
entity reference: IP3R
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot P13678 215
type: UnificationXref
id: P13678
db: uniprot

PTHR24356:SF347
type: RelationshipXref
id: PTHR24356:SF347
db: PANTHER Family
relationship type: By Homology

Smooth Muscle trachea, ileum, uterus c3
type: CellularLocationVocabulary
comment: Smooth Muscle (trachea, ileum, uterus)

Phosphoinositide phospholipase C
type: ProteinReference
xref: PTHR10336:SF29
xref: uniprot A0A1D5QXV8 11
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot F7CTP1 302
organism: Macaca mulatta

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1Q376 42
organism: Canis lupus familiaris

uniprot Q9W3J1 423
type: UnificationXref
id: Q9W3J1
db: uniprot

uniprot P50154 357
type: UnificationXref
id: P50154
db: uniprot

Guanine nucleotide binding protein, beta 3
type: ProteinReference
xref: uniprot Q5XGD8 396
organism: Xenopus tropicalis

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 14

uniprot F1MLS3 36
type: UnificationXref
id: F1MLS3
db: uniprot

uniprot P50148 353
type: UnificationXref
id: P50148
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: PTHR10336:SF31
xref: uniprot A0A2I3RV12 15
organism: Pan troglodytes

Protein kinase C-like 1B
type: ProteinReference
xref: PTHR24356:SF240
xref: uniprot P34885 223
organism: Caenorhabditis elegans

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_re21
controller: DAG

uniprot A0A2I3TRC4 249
type: UnificationXref
id: A0A2I3TRC4
db: uniprot

Protein CBR-ITR-1, isoform a
type: ProteinReference
xref: uniprot H8WGV2 157
xref: PTHR13715:SF87
organism: Caenorhabditis briggsae

uniprot Q9Y0A1 169
type: UnificationXref
id: Q9Y0A1
db: uniprot

uniprot A0A1D5R8E9 12
type: UnificationXref
id: A0A1D5R8E9
db: uniprot

Guanine nucleotide-binding protein subunit beta-5a
type: ProteinReference
xref: uniprot A1L271 252
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZSF0 261
organism: Branchiostoma floridae

uniprot P29995 162
type: UnificationXref
id: P29995
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: uniprot Q7ZUC5 245
xref: PTHR24356:SF365
organism: Danio rerio

G protein subunit alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot A0A2I3TRC4 249
organism: Pan troglodytes

uniprot Q91UZ1 122
type: UnificationXref
id: Q91UZ1
db: uniprot

ncbitaxon 9258 53
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot G3V8K2 318
type: UnificationXref
id: G3V8K2
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q9QW07 131
organism: Rattus norvegicus

PTHR24356:SF159
type: RelationshipXref
id: PTHR24356:SF159
db: PANTHER Family
relationship type: By Homology

uniprot Q5EAP4 391
type: UnificationXref
id: Q5EAP4
db: uniprot

PTHR24356:SF158
type: RelationshipXref
id: PTHR24356:SF158
db: PANTHER Family
relationship type: By Homology

uniprot E1C795 266
type: UnificationXref
id: E1C795
db: uniprot

uniprot F7CXD0 303
type: UnificationXref
id: F7CXD0
db: uniprot

uniprot Q9Z1B3 135
type: UnificationXref
id: Q9Z1B3
db: uniprot

PTHR24356:SF365
type: RelationshipXref
id: PTHR24356:SF365
db: PANTHER Family
relationship type: By Homology

uniprot K7CBH8 205
type: UnificationXref
id: K7CBH8
db: uniprot

Putative protein kinase C delta type homolog
type: ProteinReference
xref: PTHR24356:SF347
xref: uniprot P83099 228
organism: Drosophila melanogaster

uniprot Q99P84 126
type: UnificationXref
id: Q99P84
db: uniprot

uniprot F1PS03 41
type: UnificationXref
id: F1PS03
db: uniprot

uniprot E1BKE7 146
type: UnificationXref
id: E1BKE7
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot F6RA79 191
organism: Monodelphis domestica

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 285
organism: Ornithorhynchus anatinus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A8XTZ1 29
organism: Caenorhabditis briggsae

PTHR24356:SF162
type: RelationshipXref
id: PTHR24356:SF162
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R9G5 269
organism: Canis lupus familiaris

uniprot Q5F3B5 392
type: UnificationXref
id: Q5F3B5
db: uniprot

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot O14775 332
organism: Homo sapiens

ncbitaxon 9544 8
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot Q15147 99
type: UnificationXref
id: Q15147
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot Q21754 100
organism: Caenorhabditis elegans

DISSOCIATION_LEFT__PIP2-RIGHT__DAG-_IP3-_re17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 452
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 454
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 453
left: PIP2
interaction type: DISSOCIATION
right: IP3
right: DAG

uniprot P10688 79
type: UnificationXref
id: P10688
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot A0A2I3SSC7 143
organism: Pan troglodytes

uniprot Q0VFC4 379
type: UnificationXref
id: Q0VFC4
db: uniprot

uniprot Q14643 166
type: UnificationXref
id: Q14643
db: uniprot

Histamine H1 receptor
type: ProteinReference
xref: uniprot P30546 139
xref: PTHR24247:SF223
organism: Bos taurus

uniprot Q9QW07 131
type: UnificationXref
id: Q9QW07
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 268
organism: Canis lupus familiaris

uniprot P29387 343
type: UnificationXref
id: P29387
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R2S3 267
organism: Canis lupus familiaris

uniprot P30546 139
type: UnificationXref
id: P30546
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
type: ProteinReference
xref: uniprot Q4KWH5 106
xref: PTHR10336:SF51
organism: Mus musculus

MODULATION
type: RelationshipTypeVocabulary

GDP
type: SmallMolecule
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P63078 370
type: UnificationXref
id: P63078
db: uniprot

PTHR10336:SF80
type: RelationshipXref
id: PTHR10336:SF80
db: PANTHER Family
relationship type: By Homology

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot Q62074 239
organism: Mus musculus

uniprot E2R9G5 269
type: UnificationXref
id: E2R9G5
db: uniprot

uniprot Q6NMA7 111
type: UnificationXref
id: Q6NMA7
db: uniprot

uniprot H2Q9G5 323
type: UnificationXref
id: H2Q9G5
db: uniprot

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot Q9JID2 420
xref: PTHR10218:SF328
organism: Rattus norvegicus

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 8

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot Q62077 108
organism: Mus musculus

G protein subunit alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot F7G1U7 312
organism: Monodelphis domestica

PTHR13715:SF87
type: RelationshipXref
id: PTHR13715:SF87
db: PANTHER Family
relationship type: By Homology

histamine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa2 446
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A3Q1N7P8 144
type: UnificationXref
id: A0A3Q1N7P8
db: uniprot

PTHR10336:SF106
type: RelationshipXref
id: PTHR10336:SF106
db: PANTHER Family
relationship type: By Homology

uniprot F7ECA6 306
type: UnificationXref
id: F7ECA6
db: uniprot

uniprot P63212 371
type: UnificationXref
id: P63212
db: uniprot

uniprot P29993 160
type: UnificationXref
id: P29993
db: uniprot

histamine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa6 438
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A1Z9X0 177
type: UnificationXref
id: A1Z9X0
db: uniprot

uniprot F1MDC9 186
type: UnificationXref
id: F1MDC9
db: uniprot

terfenadine (seldane)
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR10336:SF51
type: RelationshipXref
id: PTHR10336:SF51
db: PANTHER Family
relationship type: By Homology

uniprot P05130 209
type: UnificationXref
id: P05130
db: uniprot

uniprot Q39032 102
type: UnificationXref
id: Q39032
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: uniprot P41743 224
xref: PTHR24356:SF214
organism: Homo sapiens

DISSOCIATION
type: RelationshipTypeVocabulary

uniprot O89040 75
type: UnificationXref
id: O89040
db: uniprot

uniprot H9FVW1 70
type: UnificationXref
id: H9FVW1
db: uniprot

uniprot P13217 82
type: UnificationXref
id: P13217
db: uniprot

uniprot F7EG64 198
type: UnificationXref
id: F7EG64
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot K7CBH8 205
xref: PTHR24356:SF159
organism: Pan troglodytes

PTHR24356:SF390
type: RelationshipXref
id: PTHR24356:SF390
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50150 354
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot P50151 355
organism: Homo sapiens

uniprot A0A3Q1MSP9 176
type: UnificationXref
id: A0A3Q1MSP9
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot P50154 357
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50153 356
organism: Mus musculus

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot P50148 353
organism: Homo sapiens

G-Protein
type: ProteinReference
xref: P04488
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Histamine H1 receptor mediated signaling pathway.PROTEIN.GENERIC.G-Protein
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Guanine nucleotide-binding protein subunit alpha-11
member entity reference: Gnb1l protein
member entity reference: Uncharacterized protein
member entity reference: THO complex subunit, putative
member entity reference: G protein subunit gamma 5
member entity reference: Guanine nucleotide-binding protein subunit beta-5b
member entity reference: G protein subunit beta 4
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
member entity reference: Gbeta5
member entity reference: Guanine nucleotide-binding protein subunit beta-5
member entity reference: Guanine nucleotide-binding protein subunit alpha-14
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Gnb2 protein
member entity reference: Guanine nucleotide-binding protein subunit beta-1
member entity reference: Guanine nucleotide binding protein, q polypeptide
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: Guanine nucleotide-binding protein (G protein), beta 5
member entity reference: G protein subunit beta 3
member entity reference: Gnb3 protein
member entity reference: GNB4 protein
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
member entity reference: G protein subunit alpha 14
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
member entity reference: Guanine nucleotide-binding protein subunit beta-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
member entity reference: AGAP005913-PA
member entity reference: G protein subunit beta 5
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

uniprot F7BYI4 196
type: UnificationXref
id: F7BYI4
db: uniprot

histamine s3 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: histamine
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_re26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 457
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 458
left: IP3R
interaction type: STATE_TRANSITION
right: IP3R

Uncharacterized protein
type: ProteinReference
xref: PTHR10336:SF51
xref: uniprot F7GU82 61
organism: Macaca mulatta

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot F7HC75 200
organism: Macaca mulatta

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot H2QJ75 65
organism: Pan troglodytes

uniprot K7C8Z4 74
type: UnificationXref
id: K7C8Z4
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1M324 34
organism: Rattus norvegicus

PTHR10336:SF31
type: RelationshipXref
id: PTHR10336:SF31
db: PANTHER Family
relationship type: By Homology

uniprot Q61011 398
type: UnificationXref
id: Q61011
db: uniprot

PARTICIPANT STOICHIOMETRY re17 453
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

Inactive phospholipase C-like protein 2
type: ProteinReference
xref: uniprot Q8K394 118
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re17 452
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F7D5G3 59
organism: Ornithorhynchus anatinus

uniprot A5PKD6 255
type: UnificationXref
id: A5PKD6
db: uniprot

PARTICIPANT STOICHIOMETRY re17 454
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

uniprot A0A2R8QJ48 174
type: UnificationXref
id: A0A2R8QJ48
db: uniprot

uniprot F1R506 190
type: UnificationXref
id: F1R506
db: uniprot

uniprot P16885 84
type: UnificationXref
id: P16885
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: uniprot A3KGF7 24
xref: PTHR10336:SF10
organism: Mus musculus

uniprot F1M324 34
type: UnificationXref
id: F1M324
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot A0A3Q2U0G2 22
organism: Gallus gallus

uniprot F7H6T7 316
type: UnificationXref
id: F7H6T7
db: uniprot

PTHR10336:SF25
type: RelationshipXref
id: PTHR10336:SF25
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot F1MY82 187
type: UnificationXref
id: F1MY82
db: uniprot

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa10 428
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=PROTEIN

PTHR10336:SF29
type: RelationshipXref
id: PTHR10336:SF29
db: PANTHER Family
relationship type: By Homology

uniprot P30677 347
type: UnificationXref
id: P30677
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V6P8 317
organism: Rattus norvegicus

uniprot Q62711 110
type: UnificationXref
id: Q62711
db: uniprot

H1
type: ProteinReference
xref: P04485
standard name: Histamine H1 receptor
comment: ENTITY_REFERENCE_ID_DESC=Histamine H1 receptor mediated signaling pathway.PROTEIN.RECEPTOR.H1
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Histamine H1 receptor

ncbitaxon 284812 91
type: UnificationXref
id: 284812
db: ncbitaxon

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot F1MY82 187
organism: Bos taurus

uniprot Q803H5 414
type: UnificationXref
id: Q803H5
db: uniprot

uniprot Q8K4S1 120
type: UnificationXref
id: Q8K4S1
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot H2Q9G5 323
organism: Pan troglodytes

uniprot F6R543 150
type: UnificationXref
id: F6R543
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot H2QDQ1 203
xref: PTHR24356:SF193
organism: Pan troglodytes

H1
type: Protein
entity reference: H1
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa11 430
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=PROTEIN

PTHR10336:SF11
type: RelationshipXref
id: PTHR10336:SF11
db: PANTHER Family
relationship type: By Homology

PTHR10336:SF12
type: RelationshipXref
id: PTHR10336:SF12
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F1P1X4 149
xref: PTHR13715:SF53
organism: Gallus gallus

uniprot P23298 219
type: UnificationXref
id: P23298
db: uniprot

PTHR10336:SF10
type: RelationshipXref
id: PTHR10336:SF10
db: PANTHER Family
relationship type: By Homology

uniprot Q02956 232
type: UnificationXref
id: Q02956
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot A0A2I3SHP7 17
organism: Pan troglodytes

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P19174 86
organism: Homo sapiens

uniprot A0A1D5QG31 248
type: UnificationXref
id: A0A1D5QG31
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63219 378
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 377
organism: Homo sapiens

PLC
type: Protein
entity reference: PLC
feature: ACTIVE 136
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=PROTEIN

By Homology
type: RelationshipTypeVocabulary

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63217 376
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63216 375
organism: Mus musculus

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa8 442
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 374
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63214 373
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63213 372
organism: Mus musculus

uniprot Q62688 109
type: UnificationXref
id: Q62688
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 27

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q15KE4 381
organism: Danio rerio

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 63

uniprot G5EGU1 319
type: UnificationXref
id: G5EGU1
db: uniprot

uniprot A4IFL6 253
type: UnificationXref
id: A4IFL6
db: uniprot

uniprot P10686 77
type: UnificationXref
id: P10686
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot P13217 82
organism: Drosophila melanogaster

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot P29829 344
organism: Drosophila melanogaster

H1 s13 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: H1
stoichiometric coefficient: 1.0

uniprot A0A1D5R985 171
type: UnificationXref
id: A0A1D5R985
db: uniprot

PKC
type: Protein
entity reference: PKC
feature: ACTIVE 136
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=PROTEIN

PLC
type: ProteinReference
xref: P04484
standard name: Phospholipase C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Histamine H1 receptor mediated signaling pathway.PROTEIN.GENERIC.PLC
comment: ENTITY_REFERENCE_NOTES=Long Name: PLC Synonym: Synonym not specified Accession: P04484
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
member entity reference: Phosphoinositide phospholipase C
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
member entity reference: Phosphoinositide phospholipase C 5
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
member entity reference: Phosphoinositide phospholipase C 4
member entity reference: Phosphoinositide phospholipase C 1
member entity reference: Inactive phospholipase C-like protein 1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
member entity reference: Phosphoinositide phospholipase C 8
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
member entity reference: Phosphoinositide phospholipase C 7
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
member entity reference: Phosphoinositide phospholipase C (Fragment)
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
member entity reference: Phosphoinositide phospholipase C 9
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

uniprot Q05655 235
type: UnificationXref
id: Q05655
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot P51432 93
organism: Mus musculus

ncbitaxon 9598 14
type: UnificationXref
id: 9598
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7F580 309
organism: Macaca mulatta

uniprot P50151 355
type: UnificationXref
id: P50151
db: uniprot

uniprot D3ZLD6 263
type: UnificationXref
id: D3ZLD6
db: uniprot

Phosphoinositide phospholipase C 3
type: ProteinReference
xref: uniprot Q56W08 107
organism: Arabidopsis thaliana

uniprot Q01970 95
type: UnificationXref
id: Q01970
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot Q9CXP8 417
organism: Mus musculus

uniprot A0A1D5QLW6 10
type: UnificationXref
id: A0A1D5QLW6
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot F6ZKL2 57
organism: Macaca mulatta

uniprot F7ERP8 307
type: UnificationXref
id: F7ERP8
db: uniprot

G protein subunit alpha q
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot E1BA29 264
organism: Bos taurus

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot A0A1D5QG31 248
xref: PTHR10218:SF328
organism: Macaca mulatta

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RGI5 270
organism: Canis lupus familiaris

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
type: ProteinReference
xref: uniprot Q62711 110
xref: PTHR10336:SF31
organism: Rattus norvegicus

uniprot Q56W08 107
type: UnificationXref
id: Q56W08
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: uniprot A0A3Q1MRR6 175
xref: PTHR24356:SF365
organism: Bos taurus

INHIBITION
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__Complex__GDP_G_Protein__H1_-_histamine-RIGHT__Complex__H1_histamine__G_Protein_GDP_-_re31
control type: INHIBITION
controller: terfenadine (seldane)

uniprot F7BVQ1 58
type: UnificationXref
id: F7BVQ1
db: uniprot

ncbitaxon 6945 259
type: UnificationXref
id: 6945
db: ncbitaxon

TRANSPORT
type: RelationshipTypeVocabulary

uniprot A0A3Q2UD13 145
type: UnificationXref
id: A0A3Q2UD13
db: uniprot

uniprot Q8K3R3 119
type: UnificationXref
id: Q8K3R3
db: uniprot

uniprot F1PL90 38
type: UnificationXref
id: F1PL90
db: uniprot

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 394

AGAP006475-PA
type: ProteinReference
xref: uniprot Q5TQX0 167
xref: PTHR13715:SF87
organism: Anopheles gambiae

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 257

uniprot F6RA79 191
type: UnificationXref
id: F6RA79
db: uniprot

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P17343 337
organism: Caenorhabditis elegans

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot Q90XF2 246
organism: Danio rerio

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot F6VT32 192
organism: Xenopus tropicalis

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3SZ98 387
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6SD46 47
xref: PTHR10336:SF12
organism: Monodelphis domestica

uniprot A0A1D5QXV8 11
type: UnificationXref
id: A0A1D5QXV8
db: uniprot

ncbitaxon 9031 23
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot Q5BH99 388
type: UnificationXref
id: Q5BH99
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot P11881 159
organism: Mus musculus

uniprot B7Q3T6 258
type: UnificationXref
id: B7Q3T6
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot F6THW2 289
organism: Xenopus tropicalis

uniprot Q9LY51 128
type: UnificationXref
id: Q9LY51
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 262

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6SSS3 287
organism: Monodelphis domestica

ncbitaxon 7227 83
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot E2RHY4 271
type: UnificationXref
id: E2RHY4
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q1D9 321
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6W548 292
organism: Macaca mulatta

uniprot Q944C1 123
type: UnificationXref
id: Q944C1
db: uniprot

PARTICIPANT STOICHIOMETRY re31 463
type: Stoichiometry
physical entity: Complex (H1/histamine/ G-Protein/GDP)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re31 462
type: Stoichiometry
physical entity: histamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re31 461
type: Stoichiometry
physical entity: Complex (GDP/G-Protein/ H1)
stoichiometric coefficient: 1.0

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 5

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P52287 358
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q91UZ1 122
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
type: ProteinReference
xref: uniprot Q8K4S1 120
xref: PTHR10336:SF6
organism: Mus musculus

uniprot P32383 88
type: UnificationXref
id: P32383
db: uniprot

uniprot F6W548 292
type: UnificationXref
id: F6W548
db: uniprot

uniprot Q6DH55 404
type: UnificationXref
id: Q6DH55
db: uniprot

uniprot A0A2I3SSC7 143
type: UnificationXref
id: A0A2I3SSC7
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot Q9Z1B3 135
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
type: ProteinReference
xref: PTHR10336:SF6
xref: uniprot G5EFI8 64
organism: Caenorhabditis elegans

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: uniprot Q00722 94
xref: PTHR10336:SF10
organism: Homo sapiens

uniprot H2R8F8 138
type: UnificationXref
id: H2R8F8
db: uniprot

H1 s6 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: H1
stoichiometric coefficient: 1.0

Phosphoinositide phospholipase C 5
type: ProteinReference
xref: uniprot Q944C2 124
organism: Arabidopsis thaliana

uniprot F1QLX2 43
type: UnificationXref
id: F1QLX2
db: uniprot

ncbitaxon 10116 4
type: UnificationXref
id: 10116
db: ncbitaxon

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot F1M7Y5 185
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G1K7 311
xref: PTHR10218:SF316
organism: Monodelphis domestica

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 48

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7AE17 329
organism: Pan troglodytes

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot F1NG47 188
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 265
organism: Gallus gallus

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot F7BIC2 195
organism: Macaca mulatta

GDP s11 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot E2RGU7 183
organism: Canis lupus familiaris

Phosphoinositide phospholipase C 4
type: ProteinReference
xref: uniprot Q944C1 123
organism: Arabidopsis thaliana

uniprot Q6TH03 409
type: UnificationXref
id: Q6TH03
db: uniprot

Protein kinase C gamma type
type: ProteinReference
xref: uniprot P05129 208
xref: PTHR24356:SF162
organism: Homo sapiens

uniprot E1BA29 264
type: UnificationXref
id: E1BA29
db: uniprot

uniprot H2QNS5 324
type: UnificationXref
id: H2QNS5
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05126 206
xref: PTHR24356:SF158
organism: Bos taurus

Protein kinase C gamma type (Fragment)
type: ProteinReference
xref: uniprot P05128 207
xref: PTHR24356:SF162
organism: Bos taurus

uniprot P52287 358
type: UnificationXref
id: P52287
db: uniprot

uniprot Q6P025 405
type: UnificationXref
id: Q6P025
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot F6R543 150
organism: Monodelphis domestica

uniprot P10895 81
type: UnificationXref
id: P10895
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 313
organism: Monodelphis domestica

uniprot F7BB02 300
type: UnificationXref
id: F7BB02
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot G5EBH0 62
organism: Caenorhabditis elegans

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P20444 218
organism: Mus musculus

uniprot H2R3A6 326
type: UnificationXref
id: H2R3A6
db: uniprot

uniprot P54311 359
type: UnificationXref
id: P54311
db: uniprot

STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_re21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 460
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 459
left: PKC
interaction type: STATE_TRANSITION
right: PKC

Inositol 1,4,5-trisphosphate receptor itr-1
type: ProteinReference
xref: uniprot Q9Y0A1 169
xref: PTHR13715:SF87
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DF43 402
organism: Xenopus tropicalis

Protein kinase C, brain isozyme
type: ProteinReference
xref: uniprot P05130 209
xref: PTHR24356:SF390
organism: Drosophila melanogaster

uniprot Q8R3B1 121
type: UnificationXref
id: Q8R3B1
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot H2QKD0 67
organism: Pan troglodytes

ncbitaxon 9606 85
type: UnificationXref
id: 9606
db: ncbitaxon

PTHR13715:SF52
type: RelationshipXref
id: PTHR13715:SF52
db: PANTHER Family
relationship type: By Homology

PTHR13715:SF51
type: RelationshipXref
id: PTHR13715:SF51
db: PANTHER Family
relationship type: By Homology

uniprot P38409 350
type: UnificationXref
id: P38409
db: uniprot

PTHR13715:SF53
type: RelationshipXref
id: PTHR13715:SF53
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 419
organism: Homo sapiens

Phosphoinositide phospholipase C (Fragment)
type: ProteinReference
xref: uniprot Q7PW25 114
organism: Anopheles gambiae

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot P38408 349
organism: Bos taurus

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot H9ERR5 69
organism: Macaca mulatta

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot P38409 350
xref: PTHR10218:SF328
organism: Bos taurus

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot Q10282 380
organism: Schizosaccharomyces pombe

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
type: ProteinReference
xref: PTHR10336:SF29
xref: uniprot Q86YW0 116
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
type: ProteinReference
xref: uniprot P40977 90
organism: Schizosaccharomyces pombe

uniprot Q15111 98
type: UnificationXref
id: Q15111
db: uniprot

uniprot Q80SZ7 415
type: UnificationXref
id: Q80SZ7
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RJB3 272
organism: Canis lupus familiaris

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 103

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot A0A2I3T8F7 18
organism: Pan troglodytes

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot F5HMB9 45
organism: Anopheles gambiae

uniprot A0A2I3SHP7 17
type: UnificationXref
id: A0A2I3SHP7
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P18851 338
organism: Saccharomyces cerevisiae

uniprot A0A3Q1MRR6 175
type: UnificationXref
id: A0A3Q1MRR6
db: uniprot

Guanine nucleotide-binding protein subunit beta-5b
type: ProteinReference
xref: uniprot Q6PBY0 407
organism: Danio rerio

Gbeta5
type: ProteinReference
xref: uniprot Q9W3J1 423
organism: Drosophila melanogaster

uniprot F6TQN3 51
type: UnificationXref
id: F6TQN3
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot Q99JE6 125
xref: PTHR10336:SF11
organism: Rattus norvegicus

uniprot Q7PW25 114
type: UnificationXref
id: Q7PW25
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1PJE5 281
organism: Canis lupus familiaris

G protein subunit gamma 5
type: ProteinReference
xref: uniprot H2PZA6 320
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re21 460
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot Q9UK08 422
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor
type: ProteinReference
xref: uniprot P29993 160
xref: PTHR13715:SF87
organism: Drosophila melanogaster

uniprot E2R2S8 268
type: UnificationXref
id: E2R2S8
db: uniprot

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot P29992 345
xref: PTHR10218:SF328
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot P29995 162
organism: Rattus norvegicus

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot P29994 161
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re21 459
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

Danio rerio
type: BioSource
xref: ncbitaxon 7955 44

G protein subunit alpha q
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot K6ZCJ5 328
organism: Pan troglodytes

uniprot Q99JE6 125
type: UnificationXref
id: Q99JE6
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_re26
controller: IP3

uniprot Q9DAS9 418
type: UnificationXref
id: Q9DAS9
db: uniprot

Muscle Contraction
type: Pathway

uniprot P09215 211
type: UnificationXref
id: P09215
db: uniprot

uniprot P34722 222
type: UnificationXref
id: P34722
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1MLS3 36
organism: Bos taurus

uniprot Q9HAV0 419
type: UnificationXref
id: Q9HAV0
db: uniprot

Protein kinase C, eye isozyme
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P13677 214
organism: Drosophila melanogaster

Phosphoinositide phospholipase C 1
type: ProteinReference
xref: uniprot Q39032 102
organism: Arabidopsis thaliana

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot Q7SY24 243
organism: Danio rerio

Phosphoinositide phospholipase C 2
type: ProteinReference
xref: uniprot Q39033 104
organism: Arabidopsis thaliana

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF240
xref: uniprot P13678 215
organism: Drosophila melanogaster

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 250
organism: Pan troglodytes

G protein subunit alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot F1NU41 280
organism: Gallus gallus

Guanine nucleotide binding protein, q polypeptide
type: ProteinReference
xref: uniprot E9GJ31 275
xref: PTHR10218:SF329
organism: Daphnia pulex

uniprot P08487 76
type: UnificationXref
id: P08487
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot E1BKE7 146
organism: Bos taurus

uniprot A8XTZ1 29
type: UnificationXref
id: A8XTZ1
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F1MDC9 186
xref: PTHR24351:SF182
organism: Bos taurus

uniprot Q3KRE3 386
type: UnificationXref
id: Q3KRE3
db: uniprot

Phosphoinositide phospholipase C 9
type: ProteinReference
xref: uniprot Q6NMA7 111
organism: Arabidopsis thaliana

ncbitaxon 214684 394
type: UnificationXref
id: 214684
db: ncbitaxon

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A0A2I3RKF6 13
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 296
organism: Monodelphis domestica

uniprot Q7Q6D3 412
type: UnificationXref
id: Q7Q6D3
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
type: ProteinReference
xref: uniprot Q9BRC7 127
xref: PTHR10336:SF31
organism: Homo sapiens

uniprot F6Y3N2 295
type: UnificationXref
id: F6Y3N2
db: uniprot

uniprot G5EBH0 62
type: UnificationXref
id: G5EBH0
db: uniprot

uniprot H2QZN8 325
type: UnificationXref
id: H2QZN8
db: uniprot

uniprot H2QDQ1 203
type: UnificationXref
id: H2QDQ1
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q15147 99
organism: Homo sapiens

uniprot P70227 163
type: UnificationXref
id: P70227
db: uniprot

uniprot E1BMG4 180
type: UnificationXref
id: E1BMG4
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F6XMN6 193
xref: PTHR24356:SF170
organism: Canis lupus familiaris

Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
type: ProteinReference
xref: uniprot Q6DH55 404
organism: Danio rerio

uniprot Q6PBR4 406
type: UnificationXref
id: Q6PBR4
db: uniprot

uniprot P18851 338
type: UnificationXref
id: P18851
db: uniprot

uniprot F1MX21 148
type: UnificationXref
id: F1MX21
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6TFY2 288
organism: Macaca mulatta

uniprot F7GU82 61
type: UnificationXref
id: F7GU82
db: uniprot

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re18
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 465
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 464
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

Phosphoinositide phospholipase C 7
type: ProteinReference
xref: uniprot Q9LY51 128
organism: Arabidopsis thaliana

Inactive phospholipase C-like protein 1
type: ProteinReference
xref: uniprot Q15111 98
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot K7BA21 73
organism: Pan troglodytes

Histamine H1 receptor
type: ProteinReference
xref: uniprot H2R8F8 138
xref: PTHR24247:SF223
organism: Pan troglodytes

uniprot F2Z3T8 282
type: UnificationXref
id: F2Z3T8
db: uniprot

uniprot P24723 220
type: UnificationXref
id: P24723
db: uniprot

uniprot H9ERR5 69
type: UnificationXref
id: H9ERR5
db: uniprot

uniprot Q9Z329 170
type: UnificationXref
id: Q9Z329
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 4

PTHR10336:SF6
type: RelationshipXref
id: PTHR10336:SF6
db: PANTHER Family
relationship type: By Homology

uniprot A8XRA5 28
type: UnificationXref
id: A8XRA5
db: uniprot

uniprot P63215 374
type: UnificationXref
id: P63215
db: uniprot

uniprot Q7ZUC5 245
type: UnificationXref
id: Q7ZUC5
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot Q05655 235
organism: Homo sapiens

eco ECO:0000250 5
type: UnificationXref
id: ECO:0000250
db: eco

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 274

INHIBITION
type: RelationshipTypeVocabulary

uniprot Q9VXH3 133
type: UnificationXref
id: Q9VXH3
db: uniprot

uniprot F7DVL1 197
type: UnificationXref
id: F7DVL1
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot E1BWA3 182
xref: PTHR24356:SF214
organism: Gallus gallus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63078 370
organism: Mus musculus

uniprot K7E376 330
type: UnificationXref
id: K7E376
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 369
organism: Rattus norvegicus

uniprot F6QJP0 137
type: UnificationXref
id: F6QJP0
db: uniprot

uniprot P63217 376
type: UnificationXref
id: P63217
db: uniprot

uniprot A3KGF7 24
type: UnificationXref
id: A3KGF7
db: uniprot

uniprot G3V6P8 317
type: UnificationXref
id: G3V6P8
db: uniprot

ncbitaxon 6239 63
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot Q86YW0 116
type: UnificationXref
id: Q86YW0
db: uniprot

uniprot F6ZCW7 153
type: UnificationXref
id: F6ZCW7
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 360
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 359
organism: Rattus norvegicus

uniprot H2QJ75 65
type: UnificationXref
id: H2QJ75
db: uniprot

uniprot Q08BT6 236
type: UnificationXref
id: Q08BT6
db: uniprot

uniprot Q6DGZ5 403
type: UnificationXref
id: Q6DGZ5
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F1PS03 41
organism: Canis lupus familiaris

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot H9FVW1 70
organism: Macaca mulatta

uniprot E2RGI5 270
type: UnificationXref
id: E2RGI5
db: uniprot

uniprot F7CFG8 301
type: UnificationXref
id: F7CFG8
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 304
organism: Ornithorhynchus anatinus

Protein kinase C
type: ProteinReference
xref: uniprot A0A2I3RQJ8 172
xref: PTHR24356:SF214
organism: Pan troglodytes

uniprot P29992 345
type: UnificationXref
id: P29992
db: uniprot

G protein subunit alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot Q5EAP4 391
organism: Rattus norvegicus

uniprot O95837 334
type: UnificationXref
id: O95837
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 408
organism: Danio rerio

uniprot P21279 340
type: UnificationXref
id: P21279
db: uniprot

uniprot P11881 159
type: UnificationXref
id: P11881
db: uniprot

uniprot Q9CXP8 417
type: UnificationXref
id: Q9CXP8
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A0A1D5Q3D7 7
xref: PTHR10336:SF31
organism: Macaca mulatta

uniprot Q61016 399
type: UnificationXref
id: Q61016
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot A8KBH6 178
organism: Xenopus tropicalis

uniprot A8WR64 179
type: UnificationXref
id: A8WR64
db: uniprot

G protein alpha q subunit
type: ProteinReference
xref: PTHR10218:SF329
xref: uniprot P23625 341
organism: Drosophila melanogaster

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 277

uniprot F1NG47 188
type: UnificationXref
id: F1NG47
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot Q14573 165
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot Q14571 164
organism: Homo sapiens

uniprot A0A2I3RVP2 16
type: UnificationXref
id: A0A2I3RVP2
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot Q9XWB7 134
organism: Caenorhabditis elegans

uniprot Q04759 233
type: UnificationXref
id: Q04759
db: uniprot

uniprot P09217 213
type: UnificationXref
id: P09217
db: uniprot

uniprot A0A096MJW8 3
type: UnificationXref
id: A0A096MJW8
db: uniprot

uniprot Q7Q042 241
type: UnificationXref
id: Q7Q042
db: uniprot

uniprot F7H3B3 199
type: UnificationXref
id: F7H3B3
db: uniprot

uniprot H2QLZ4 155
type: UnificationXref
id: H2QLZ4
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F7BYI4 196
xref: PTHR24356:SF158
organism: Macaca mulatta

Protein kinase C
type: ProteinReference
xref: uniprot Q7QCP8 242
xref: PTHR24356:SF240
organism: Anopheles gambiae

uniprot F1A421 276
type: UnificationXref
id: F1A421
db: uniprot

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot H2QJY5 66
organism: Pan troglodytes

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot E2RT75 33
xref: PTHR10336:SF10
organism: Canis lupus familiaris

uniprot Q8K394 118
type: UnificationXref
id: Q8K394
db: uniprot

uniprot Q39033 104
type: UnificationXref
id: Q39033
db: uniprot

uniprot P62872 363
type: UnificationXref
id: P62872
db: uniprot

Guanine nucleotide-binding protein (G protein), beta 5
type: ProteinReference
xref: uniprot F7EBE7 305
organism: Xenopus tropicalis

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P59768 361
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6V461 290
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P16520 336
organism: Homo sapiens

uniprot F7BIC2 195
type: UnificationXref
id: F7BIC2
db: uniprot

H1 s2 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: H1
stoichiometric coefficient: 1.0

GTP s4 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot Q5XGD8 396
type: UnificationXref
id: Q5XGD8
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 389

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6PBR4 406
organism: Danio rerio

uniprot Q14571 164
type: UnificationXref
id: Q14571
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot Q9NQ66 129
xref: PTHR10336:SF12
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DGZ5 403
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot J9P702 327
organism: Canis lupus familiaris

uniprot P63219 378
type: UnificationXref
id: P63219
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot A0A1D5R8E9 12
organism: Macaca mulatta

uniprot Q28FH0 384
type: UnificationXref
id: Q28FH0
db: uniprot

uniprot Q5ZJ03 397
type: UnificationXref
id: Q5ZJ03
db: uniprot

uniprot P51178 92
type: UnificationXref
id: P51178
db: uniprot

uniprot Q4KWH5 106
type: UnificationXref
id: Q4KWH5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_re28
controller: Complex (GTP/G-Protein)

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A8XRA5 28
xref: PTHR10336:SF6
organism: Caenorhabditis briggsae

uniprot A0A2J8QDF6 19
type: UnificationXref
id: A0A2J8QDF6
db: uniprot

uniprot H2QJY5 66
type: UnificationXref
id: H2QJY5
db: uniprot

uniprot F7E427 304
type: UnificationXref
id: F7E427
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot E1BH60 30
organism: Bos taurus

uniprot J9P702 327
type: UnificationXref
id: J9P702
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F6TAH0 50
organism: Monodelphis domestica

Inactive phospholipase C-like protein 1
type: ProteinReference
xref: uniprot Q62688 109
organism: Rattus norvegicus

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A0A2I3RVP2 16
xref: PTHR10336:SF29
organism: Pan troglodytes

uniprot Q15KE4 381
type: UnificationXref
id: Q15KE4
db: uniprot

PTHR45816:SF3
type: RelationshipXref
id: PTHR45816:SF3
db: PANTHER Family
relationship type: By Homology

uniprot O60262 333
type: UnificationXref
id: O60262
db: uniprot

uniprot Q3SZ98 387
type: UnificationXref
id: Q3SZ98
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot F6TQN3 51
organism: Monodelphis domestica

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A0A3Q1MMD9 20
xref: PTHR10336:SF25
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot F7FXA9 310
organism: Macaca mulatta

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa9 426
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q7T2C5 244
type: UnificationXref
id: Q7T2C5
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot P29387 343
organism: Mus musculus

uniprot F1PLB3 40
type: UnificationXref
id: F1PLB3
db: uniprot

uniprot F7G1U7 312
type: UnificationXref
id: F7G1U7
db: uniprot

Phosphoinositide phospholipase C (Fragment)
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F1QLX2 43
organism: Danio rerio

uniprot A0A2I3T8F7 18
type: UnificationXref
id: A0A2I3T8F7
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QZN8 325
organism: Pan troglodytes

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 390
organism: Danio rerio

uniprot Q02158 96
type: UnificationXref
id: Q02158
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot H2QLZ4 155
organism: Pan troglodytes

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 89

uniprot P63077 369
type: UnificationXref
id: P63077
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot H2QSU0 156
organism: Pan troglodytes

uniprot F7ASR8 299
type: UnificationXref
id: F7ASR8
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 83

uniprot F1M7Y5 185
type: UnificationXref
id: F1M7Y5
db: uniprot

uniprot H2QAS6 202
type: UnificationXref
id: H2QAS6
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 398
organism: Mus musculus

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot Q02956 232
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
type: ProteinReference
xref: uniprot Q22070 101
organism: Caenorhabditis elegans

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1P354 37
organism: Gallus gallus

ncbitaxon 9913 21
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot P62879 366
type: UnificationXref
id: P62879
db: uniprot

uniprot Q7QHE3 115
type: UnificationXref
id: Q7QHE3
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot Q63269 168
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot H9ZA60 71
xref: PTHR10336:SF10
organism: Macaca mulatta

Protein kinase C
type: ProteinReference
xref: uniprot F1R506 190
xref: PTHR24356:SF181
organism: Danio rerio

PTHR10218:SF213
type: RelationshipXref
id: PTHR10218:SF213
db: PANTHER Family
relationship type: By Homology

uniprot F1PL99 39
type: UnificationXref
id: F1PL99
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot Q64617 240
organism: Rattus norvegicus

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot Q9Z329 170
organism: Mus musculus

ncbitaxon 665079 257
type: UnificationXref
id: 665079
db: ncbitaxon

uniprot F1P3G1 189
type: UnificationXref
id: F1P3G1
db: uniprot

uniprot P09216 212
type: UnificationXref
id: P09216
db: uniprot

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P63318 225
organism: Mus musculus

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P63319 226
organism: Rattus norvegicus

histamine s7 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: histamine
stoichiometric coefficient: 1.0

AGAP001506-PA
type: ProteinReference
xref: uniprot Q7PXP3 410
organism: Anopheles gambiae

uniprot H2Q1D9 321
type: UnificationXref
id: H2Q1D9
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot Q66JF0 401
organism: Xenopus tropicalis

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot F6VHF7 151
organism: Xenopus tropicalis

uniprot F7GI54 315
type: UnificationXref
id: F7GI54
db: uniprot

Protein kinase C-like 2
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P90980 229
organism: Caenorhabditis elegans

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot E2RQM0 31
organism: Canis lupus familiaris

uniprot P63213 372
type: UnificationXref
id: P63213
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 399
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot Q61017 400
organism: Mus musculus

uniprot P90980 229
type: UnificationXref
id: P90980
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot F6ZCW7 153
organism: Monodelphis domestica

uniprot E1BW98 265
type: UnificationXref
id: E1BW98
db: uniprot

IP3R
type: ProteinReference
xref: P04486
standard name: inositol 1,4,5-triphosphate receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES=Long Name: IP3R Synonym: Synonym not specified Accession: P04486
comment: ENTITY_REFERENCE_ID_DESC=Histamine H1 receptor mediated signaling pathway.PROTEIN.ION_CHANNEL.IP_sub_3_endsub_R
member entity reference: Inositol 1,4,5-trisphosphate receptor itr-1
member entity reference: Inositol 1,4,5-trisphosphate receptor type 2
member entity reference: Uncharacterized protein
member entity reference: Inositol 1,4,5-trisphosphate receptor type 3
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1 isoform 3
member entity reference: Inositol 1,4,5-trisphosphate receptor
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1
member entity reference: AGAP006475-PA
member entity reference: Protein CBR-ITR-1, isoform a

ncbitaxon 367110 284
type: UnificationXref
id: 367110
db: ncbitaxon

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot P23298 219
organism: Mus musculus

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1PL99 39
organism: Canis lupus familiaris

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 55

uniprot H2RB55 68
type: UnificationXref
id: H2RB55
db: uniprot

uniprot P63218 377
type: UnificationXref
id: P63218
db: uniprot

TRIGGER
type: RelationshipTypeVocabulary

uniprot F6VT32 192
type: UnificationXref
id: F6VT32
db: uniprot

uniprot P62880 367
type: UnificationXref
id: P62880
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot Q7QHE3 115
organism: Anopheles gambiae

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F1PL90 38
xref: PTHR10336:SF12
organism: Canis lupus familiaris

uniprot F7G1K7 311
type: UnificationXref
id: F7G1K7
db: uniprot

Ca2+
type: SmallMolecule
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=ION

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot O14610 331
organism: Homo sapiens

uniprot P54313 360
type: UnificationXref
id: P54313
db: uniprot

uniprot H2QSU0 156
type: UnificationXref
id: H2QSU0
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P49177 352
organism: Arabidopsis thaliana

uniprot Q05513 234
type: UnificationXref
id: Q05513
db: uniprot

uniprot Q5RKP9 395
type: UnificationXref
id: Q5RKP9
db: uniprot

uniprot A8X1E0 26
type: UnificationXref
id: A8X1E0
db: uniprot

uniprot Q9NQ66 129
type: UnificationXref
id: Q9NQ66
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 335
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot E1BMG4 180
organism: Bos taurus

uniprot Q64617 240
type: UnificationXref
id: Q64617
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot P24723 220
organism: Homo sapiens

uniprot Q21754 100
type: UnificationXref
id: Q21754
db: uniprot

uniprot Q02111 230
type: UnificationXref
id: Q02111
db: uniprot

uniprot Q14573 165
type: UnificationXref
id: Q14573
db: uniprot

uniprot A1L271 252
type: UnificationXref
id: A1L271
db: uniprot

uniprot Q6Z3Y9 112
type: UnificationXref
id: Q6Z3Y9
db: uniprot

uniprot F6XMN6 193
type: UnificationXref
id: F6XMN6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T7 316
organism: Macaca mulatta

uniprot P10894 80
type: UnificationXref
id: P10894
db: uniprot

uniprot Q02156 231
type: UnificationXref
id: Q02156
db: uniprot

uniprot E2RT75 33
type: UnificationXref
id: E2RT75
db: uniprot

ncbitaxon 13616 48
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot F1NU41 280
type: UnificationXref
id: F1NU41
db: uniprot

uniprot E1BWA3 182
type: UnificationXref
id: E1BWA3
db: uniprot

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 2

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot F5HH30 283
organism: Neurospora crassa

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P43425 351
organism: Rattus norvegicus

uniprot P51432 93
type: UnificationXref
id: P51432
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IGZ2 254
organism: Xenopus tropicalis

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot Q02158 96
organism: Dictyostelium discoideum

uniprot A0A3Q1MMD9 20
type: UnificationXref
id: A0A3Q1MMD9
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot Q02156 231
xref: PTHR24356:SF159
organism: Homo sapiens

uniprot F1MKT3 35
type: UnificationXref
id: F1MKT3
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q28024 383
organism: Bos taurus

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot E2RMC0 147
organism: Canis lupus familiaris

PTHR24351:SF182
type: RelationshipXref
id: PTHR24351:SF182
db: PANTHER Family
relationship type: By Homology

uniprot Q19266 237
type: UnificationXref
id: Q19266
db: uniprot

uniprot F6VHF7 151
type: UnificationXref
id: F6VHF7
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XWE8 294
organism: Monodelphis domestica

uniprot P29829 344
type: UnificationXref
id: P29829
db: uniprot

uniprot Q7Q6D4 413
type: UnificationXref
id: Q7Q6D4
db: uniprot

uniprot Q5TQX0 167
type: UnificationXref
id: Q5TQX0
db: uniprot

uniprot E9FUX0 273
type: UnificationXref
id: E9FUX0
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot P70227 163
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot F6VQP7 152
organism: Monodelphis domestica

DISSOCIATION_LEFT__Complex__H1_histamine__G_Protein_GDP_-_GTP-RIGHT__GDP-_Complex__GTP_G_Protein_-_Complex__H1_histamine_-_re30
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 451
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 449
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 447
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 450
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 448
left: Complex (H1/histamine/ G-Protein/GDP)
left: GTP
interaction type: DISSOCIATION
right: GDP
right: Complex (GTP/G-Protein)
right: Complex (H1/histamine)

uniprot Q90XF2 246
type: UnificationXref
id: Q90XF2
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: PTHR45816:SF3
xref: uniprot A0A3Q1N7P8 144
organism: Bos taurus

AGAP005911-PA
type: ProteinReference
xref: uniprot Q7Q6D4 413
organism: Anopheles gambiae

uniprot P43425 351
type: UnificationXref
id: P43425
db: uniprot

AGAP005913-PA
type: ProteinReference
xref: uniprot Q7Q6D2 411
organism: Anopheles gambiae

PTHR24356:SF240
type: RelationshipXref
id: PTHR24356:SF240
db: PANTHER Family
relationship type: By Homology

AGAP005912-PA
type: ProteinReference
xref: uniprot Q7Q6D3 412
organism: Anopheles gambiae

Bos taurus
type: BioSource
xref: ncbitaxon 9913 21

uniprot F6SSS3 287
type: UnificationXref
id: F6SSS3
db: uniprot

uniprot P17343 337
type: UnificationXref
id: P17343
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 53

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q3W7 322
organism: Pan troglodytes

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
type: ProteinReference
xref: uniprot P10895 81
xref: PTHR10336:SF80
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot P10894 80
xref: PTHR10336:SF12
organism: Bos taurus

uniprot F6ZKL2 57
type: UnificationXref
id: F6ZKL2
db: uniprot

uniprot P63319 226
type: UnificationXref
id: P63319
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: uniprot O89040 75
xref: PTHR10336:SF10
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot F7BVQ1 58
xref: PTHR10336:SF25
organism: Monodelphis domestica

uniprot P59768 361
type: UnificationXref
id: P59768
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q28H40 385
organism: Xenopus tropicalis

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P30671 346
organism: Bos taurus

histamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 259

uniprot P11017 335
type: UnificationXref
id: P11017
db: uniprot

uniprot P23625 341
type: UnificationXref
id: P23625
db: uniprot

uniprot E2RQM0 31
type: UnificationXref
id: E2RQM0
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P08487 76
organism: Bos taurus

uniprot P63216 375
type: UnificationXref
id: P63216
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot F7A818 154
organism: Macaca mulatta

uniprot A0A2I3SR38 173
type: UnificationXref
id: A0A2I3SR38
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot A0A2I3SR38 173
xref: PTHR24356:SF181
organism: Pan troglodytes

PTHR24356:SF214
type: RelationshipXref
id: PTHR24356:SF214
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot F1A421 276
organism: Dictyostelium purpureum

uniprot J9JHK9 72
type: UnificationXref
id: J9JHK9
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 32

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot Q08BT6 236
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NGS8 251
organism: Bos taurus

uniprot Q20636 382
type: UnificationXref
id: Q20636
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 324
organism: Pan troglodytes

uniprot F7F580 309
type: UnificationXref
id: F7F580
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7G7I9 314
organism: Ornithorhynchus anatinus

ncbitaxon 7739 262
type: UnificationXref
id: 7739
db: ncbitaxon

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa3 432
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 6238 27
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot P49177 352
type: UnificationXref
id: P49177
db: uniprot

IP3R
type: Protein
entity reference: IP3R
feature: ACTIVE 136
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot H8WGV2 157
type: UnificationXref
id: H8WGV2
db: uniprot

uniprot E1BH60 30
type: UnificationXref
id: E1BH60
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7CFG8 301
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot P30677 347
organism: Mus musculus

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 23

uniprot F1P1X4 149
type: UnificationXref
id: F1P1X4
db: uniprot

uniprot F6ZIZ9 297
type: UnificationXref
id: F6ZIZ9
db: uniprot

uniprot P83099 228
type: UnificationXref
id: P83099
db: uniprot

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q02111 230
xref: PTHR24356:SF181
organism: Mus musculus

uniprot Q9UK08 422
type: UnificationXref
id: Q9UK08
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot Q5PU49 238
organism: Canis lupus familiaris

Inositol 1,4,5-trisphosphate receptor type 1 isoform 3
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot H9FU38 158
organism: Macaca mulatta

INHIBITION
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__Complex__GDP_G_Protein__H1_-_histamine-RIGHT__Complex__H1_histamine__G_Protein_GDP_-_re31
control type: INHIBITION
controller: loratadine (claritin)

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot F7ECA6 306
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7GI54 315
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot P21278 339
xref: PTHR10218:SF328
organism: Mus musculus

uniprot F1P354 37
type: UnificationXref
id: F1P354
db: uniprot

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot P21279 340
organism: Mus musculus

uniprot P34885 223
type: UnificationXref
id: P34885
db: uniprot

uniprot F7A632 194
type: UnificationXref
id: F7A632
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot F1PLB3 40
organism: Canis lupus familiaris

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa7 440
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=PROTEIN

Phosphoinositide phospholipase C 8
type: ProteinReference
xref: uniprot Q9STZ3 132
organism: Arabidopsis thaliana

Gnb3 protein
type: ProteinReference
xref: uniprot Q6P025 405
organism: Danio rerio

uniprot Q9STZ3 132
type: UnificationXref
id: Q9STZ3
db: uniprot

H1
type: Protein
entity reference: H1
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa5 436
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=PROTEIN

uniprot E9GJ31 275
type: UnificationXref
id: E9GJ31
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: uniprot P68404 227
xref: PTHR24356:SF158
organism: Mus musculus

uniprot F7HC75 200
type: UnificationXref
id: F7HC75
db: uniprot

PKC
type: ProteinReference
xref: P04487
standard name: Protein kinase C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: PKC Synonym: Synonym not specified Accession: P04487
comment: ENTITY_REFERENCE_ID_DESC=Histamine H1 receptor mediated signaling pathway.PROTEIN.GENERIC.PKC
member entity reference: Protein kinase C
member entity reference: Protein kinase C eta type
member entity reference: Protein kinase C beta type
member entity reference: Protein kinase C delta type
member entity reference: Protein kinase C iota type
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C gamma type
member entity reference: Protein kinase C zeta type
member entity reference: Protein kinase C-like 1
member entity reference: Protein kinase C theta type
member entity reference: Protein kinase C alpha type
member entity reference: Protein kinase C, brain isozyme
member entity reference: Protein kinase C-like 2
member entity reference: Protein kinase C-like 3
member entity reference: Protein kinase C-like 1B
member entity reference: AGAP012252-PA (Fragment)
member entity reference: Protein kinase C, eye isozyme
member entity reference: Atypical protein kinase C
member entity reference: Protein kinase C gamma type (Fragment)
member entity reference: Putative protein kinase C delta type homolog

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5KI86 393
organism: Cryptococcus neoformans

GTP
type: SmallMolecule
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide binding protein, beta subunit
type: ProteinReference
xref: uniprot E9FUX0 273
organism: Daphnia pulex

uniprot F7G7I9 314
type: UnificationXref
id: F7G7I9
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
type: ProteinReference
xref: PTHR10336:SF80
xref: uniprot P51178 92
organism: Homo sapiens

uniprot P36408 348
type: UnificationXref
id: P36408
db: uniprot

uniprot Q22070 101
type: UnificationXref
id: Q22070
db: uniprot

ncbitaxon 559292 89
type: UnificationXref
id: 559292
db: ncbitaxon

Guanine nucleotide-binding protein (G protein), q polypeptide
type: ProteinReference
xref: uniprot Q28FH0 384
xref: PTHR10218:SF316
organism: Xenopus tropicalis

uniprot Q944C2 124
type: UnificationXref
id: Q944C2
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6VVA6 52
xref: PTHR10336:SF12
organism: Ornithorhynchus anatinus

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__PIP2-RIGHT__DAG-_IP3-_re17
controller: PLC

uniprot E2RGU7 183
type: UnificationXref
id: E2RGU7
db: uniprot

uniprot P10687 78
type: UnificationXref
id: P10687
db: uniprot

uniprot F7ES96 308
type: UnificationXref
id: F7ES96
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9UBI6 421
organism: Homo sapiens

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot F7DVL1 197
organism: Xenopus tropicalis

uniprot A0A3Q1NGS8 251
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

uniprot Q6DF43 402
type: UnificationXref
id: Q6DF43
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot H2QAS6 202
xref: PTHR24356:SF158
organism: Pan troglodytes

uniprot F6VVA6 52
type: UnificationXref
id: F6VVA6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 286
organism: Monodelphis domestica

Protein kinase C
type: ProteinReference
xref: uniprot E1BQN6 181
xref: PTHR24356:SF170
organism: Gallus gallus

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot F7AQR3 298
organism: Macaca mulatta

STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_re28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 456
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 455
left: PLC
interaction type: STATE_TRANSITION
right: PLC

HETERODIMER_ASSOCIATION_LEFT__Complex__GDP_G_Protein__H1_-_histamine-RIGHT__Complex__H1_histamine__G_Protein_GDP_-_re31
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 463
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 462
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 461
left: histamine
left: Complex (GDP/G-Protein/ H1)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (H1/histamine/ G-Protein/GDP)

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 295
organism: Monodelphis domestica

THO complex subunit, putative
type: ProteinReference
xref: uniprot B7Q3T6 258
organism: Ixodes scapularis

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XHP0 293
organism: Macaca mulatta

Phosphoinositide phospholipase C
type: ProteinReference
xref: PTHR10336:SF6
xref: uniprot H2RB55 68
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9DAS9 418
organism: Mus musculus

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot H2Q8F2 201
organism: Pan troglodytes

uniprot A4IGZ2 254
type: UnificationXref
id: A4IGZ2
db: uniprot

uniprot F6ZC55 56
type: UnificationXref
id: F6ZC55
db: uniprot

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: uniprot O95837 334
xref: PTHR10218:SF213
organism: Homo sapiens

Complex (H1/histamine/ G-Protein/GDP)
type: Complex
component stoichiometry: GDP s10 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: H1 s6 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: histamine s7 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s8 sa7 STOICHIOMETRY ID COMPLEX
component: histamine
component: G-Protein
component: GDP
component: H1
feature: COMPLEX BINDING FEATURE s109 a92 437
feature: COMPLEX BINDING FEATURE s109 a92 435
feature: COMPLEX BINDING FEATURE s109 a92 441
feature: COMPLEX BINDING FEATURE s109 a92 439
cellular location: Smooth Muscle trachea, ileum, uterus c3

uniprot P20444 218
type: UnificationXref
id: P20444
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot A0A3Q2UD13 145
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ASR8 299
organism: Macaca mulatta

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05771 210
xref: PTHR24356:SF158
organism: Homo sapiens

ncbitaxon 7165 46
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot F6YZA3 296
type: UnificationXref
id: F6YZA3
db: uniprot

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P26308 342
organism: Drosophila melanogaster

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 113

uniprot F7A818 154
type: UnificationXref
id: F7A818
db: uniprot

uniprot Q7SY24 243
type: UnificationXref
id: Q7SY24
db: uniprot

uniprot E2RMC0 147
type: UnificationXref
id: E2RMC0
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot A0A1D5R985 171
xref: PTHR24356:SF193
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CXD0 303
organism: Monodelphis domestica

G-protein beta subunit
type: ProteinReference
xref: uniprot Q5BH99 388
organism: Emericella nidulans

uniprot P05128 207
type: UnificationXref
id: P05128
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
type: ProteinReference
xref: PTHR10336:SF6
xref: uniprot Q99P84 126
organism: Rattus norvegicus

Protein kinase C delta type
type: ProteinReference
xref: uniprot P28867 221
xref: PTHR24356:SF365
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: uniprot E2RNP2 184
xref: PTHR24356:SF181
organism: Canis lupus familiaris

uniprot E2RNP2 184
type: UnificationXref
id: E2RNP2
db: uniprot

uniprot H2QKD0 67
type: UnificationXref
id: H2QKD0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5F3B5 392
xref: PTHR10218:SF316
organism: Gallus gallus

uniprot F6PGC8 285
type: UnificationXref
id: F6PGC8
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 46

Protein kinase C
type: ProteinReference
xref: uniprot F7A632 194
xref: PTHR24356:SF158
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 278
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
type: ProteinReference
xref: PTHR10336:SF6
xref: uniprot Q9P212 130
organism: Homo sapiens

uniprot Q5PU49 238
type: UnificationXref
id: Q5PU49
db: uniprot

uniprot F7FXA9 310
type: UnificationXref
id: F7FXA9
db: uniprot

uniprot P68404 227
type: UnificationXref
id: P68404
db: uniprot

uniprot F5HH30 283
type: UnificationXref
id: F5HH30
db: uniprot

uniprot P25455 87
type: UnificationXref
id: P25455
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7BB02 300
organism: Macaca mulatta

uniprot P62874 365
type: UnificationXref
id: P62874
db: uniprot

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 414
organism: Danio rerio

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot K7C8Z4 74
xref: PTHR10336:SF80
organism: Pan troglodytes

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F6SRP9 49
xref: PTHR10336:SF80
organism: Macaca mulatta

uniprot A0A2I3RQJ8 172
type: UnificationXref
id: A0A2I3RQJ8
db: uniprot

uniprot F7E2P1 60
type: UnificationXref
id: F7E2P1
db: uniprot

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa4 434
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=PROTEIN

uniprot P17252 217
type: UnificationXref
id: P17252
db: uniprot

ncbitaxon 5786 277
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot F1PJE5 281
type: UnificationXref
id: F1PJE5
db: uniprot

uniprot Q28H40 385
type: UnificationXref
id: Q28H40
db: uniprot

ncbitaxon 44689 97
type: UnificationXref
id: 44689
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3KRE3 386
organism: Rattus norvegicus

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot P16054 216
organism: Mus musculus

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot F7EG64 198
organism: Xenopus tropicalis

uniprot Q61017 400
type: UnificationXref
id: Q61017
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot E2RHY4 271
organism: Canis lupus familiaris

uniprot Q9BRC7 127
type: UnificationXref
id: Q9BRC7
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: uniprot F1P3G1 189
xref: PTHR24356:SF365
organism: Gallus gallus

uniprot Q9JID2 420
type: UnificationXref
id: Q9JID2
db: uniprot

uniprot P30671 346
type: UnificationXref
id: P30671
db: uniprot

uniprot H2PZA6 320
type: UnificationXref
id: H2PZA6
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot O60262 333
organism: Homo sapiens

uniprot F6V461 290
type: UnificationXref
id: F6V461
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
type: ProteinReference
xref: PTHR10336:SF31
xref: uniprot Q8K3R3 119
organism: Mus musculus

uniprot F6VPY1 291
type: UnificationXref
id: F6VPY1
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot D3ZLD6 263
organism: Rattus norvegicus

uniprot A0A2I3RV12 15
type: UnificationXref
id: A0A2I3RV12
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re18
control type: ACTIVATION
controller: IP3R

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 91

PARTICIPANT STOICHIOMETRY re30 449
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re30 448
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re30 447
type: Stoichiometry
physical entity: Complex (H1/histamine/ G-Protein/GDP)
stoichiometric coefficient: 1.0

uniprot A0A1D5Q3D7 7
type: UnificationXref
id: A0A1D5Q3D7
db: uniprot

uniprot H9ZA60 71
type: UnificationXref
id: H9ZA60
db: uniprot

uniprot Q7PXP3 410
type: UnificationXref
id: Q7PXP3
db: uniprot

uniprot H9FU38 158
type: UnificationXref
id: H9FU38
db: uniprot

Histamine H1 receptor
type: ProteinReference
xref: uniprot F6QJP0 137
xref: PTHR24247:SF223
organism: Macaca mulatta

DISSOCIATION
type: InteractionVocabulary

PARTICIPANT STOICHIOMETRY re28 455
type: Stoichiometry
physical entity: PLC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 456
type: Stoichiometry
physical entity: PLC
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q0VFC4 379
organism: Xenopus tropicalis

uniprot P40977 90
type: UnificationXref
id: P40977
db: uniprot

Histamine H1 receptor
type: ProteinReference
xref: uniprot P31390 140
xref: PTHR24247:SF223
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6TH03 409
organism: Danio rerio

TRIGGER
type: Control
xref: TRIGGER
controlled: Muscle Contraction
controller: Ca2+

PARTICIPANT STOICHIOMETRY re30 450
type: Stoichiometry
physical entity: Complex (GTP/G-Protein)
stoichiometric coefficient: 1.0

uniprot P16054 216
type: UnificationXref
id: P16054
db: uniprot

PARTICIPANT STOICHIOMETRY re30 451
type: Stoichiometry
physical entity: Complex (H1/histamine)
stoichiometric coefficient: 1.0

uniprot K7BA21 73
type: UnificationXref
id: K7BA21
db: uniprot

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot Q20636 382
organism: Caenorhabditis elegans

GNB4 protein
type: ProteinReference
xref: uniprot A5PKD6 255
organism: Bos taurus

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 85

uniprot P50153 356
type: UnificationXref
id: P50153
db: uniprot

uniprot P13677 214
type: UnificationXref
id: P13677
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot F1MX21 148
organism: Bos taurus

ncbitaxon 8364 55
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot P62873 364
type: UnificationXref
id: P62873
db: uniprot

uniprot F5HMB9 45
type: UnificationXref
id: F5HMB9
db: uniprot

uniprot A0A3Q2U0G2 22
type: UnificationXref
id: A0A3Q2U0G2
db: uniprot

uniprot Q5BJ11 390
type: UnificationXref
id: Q5BJ11
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E1C795 266
organism: Gallus gallus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
type: ProteinReference
xref: uniprot P32383 88
organism: Saccharomyces cerevisiae

PTHR10336:SF173
type: RelationshipXref
id: PTHR10336:SF173
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot R4GKD1 424
organism: Gallus gallus

Atypical protein kinase C
type: ProteinReference
xref: PTHR24356:SF303
xref: uniprot A1Z9X0 177
organism: Drosophila melanogaster

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 308
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NLV4 279
organism: Gallus gallus

Histamine H1 receptor
type: ProteinReference
xref: PTHR24247:SF223
xref: uniprot P70174 142
organism: Mus musculus

PKC
type: Protein
entity reference: PKC
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein (G protein), q polypeptide
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot B8JLJ7 260
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V8K2 318
organism: Rattus norvegicus

uniprot F6SRP9 49
type: UnificationXref
id: F6SRP9
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1MKT3 35
xref: PTHR10336:SF31
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: uniprot Q7T2C5 244
xref: PTHR24356:SF158
organism: Danio rerio

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot A7EDU2 256
organism: Sclerotinia sclerotiorum

loratadine (claritin)
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8CIH5 117
type: UnificationXref
id: Q8CIH5
db: uniprot

uniprot F1NLV4 279
type: UnificationXref
id: F1NLV4
db: uniprot

uniprot P31390 140
type: UnificationXref
id: P31390
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot A0A2J8QDF6 19
xref: PTHR10336:SF10
organism: Pan troglodytes

uniprot F7AQR3 298
type: UnificationXref
id: F7AQR3
db: uniprot

uniprot Q62077 108
type: UnificationXref
id: Q62077
db: uniprot

Inactive phospholipase C-like protein 1
type: ProteinReference
xref: uniprot Q3USB7 105
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot P16885 84
organism: Homo sapiens

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q9WTQ0 247
xref: PTHR24356:SF181
organism: Rattus norvegicus

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 97

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F6Z8A1 54
organism: Xenopus tropicalis

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F2Z3T8 282
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
type: ProteinReference
xref: uniprot P10688 79
xref: PTHR10336:SF80
organism: Rattus norvegicus

uniprot Q00722 94
type: UnificationXref
id: Q00722
db: uniprot

uniprot Q5KI86 393
type: UnificationXref
id: Q5KI86
db: uniprot

ncbitaxon 7955 44
type: UnificationXref
id: 7955
db: ncbitaxon

IP3
type: SmallMolecule
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9UBI6 421
type: UnificationXref
id: Q9UBI6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7E376 330
organism: Monodelphis domestica

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot J9JHK9 72
xref: PTHR10336:SF11
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 415
organism: Mus musculus

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot P09217 213
organism: Rattus norvegicus

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot P09216 212
organism: Rattus norvegicus

Protein kinase C delta type
type: ProteinReference
xref: uniprot P09215 211
xref: PTHR24356:SF365
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re26 458
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

uniprot H2Q8F2 201
type: UnificationXref
id: H2Q8F2
db: uniprot

ncbitaxon 6669 274
type: UnificationXref
id: 6669
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re26 457
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

uniprot P38408 349
type: UnificationXref
id: P38408
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P10686 77
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot P10687 78
xref: PTHR10336:SF12
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q90Z40 416
organism: Danio rerio

uniprot F6SD46 47
type: UnificationXref
id: F6SD46
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot A0A1D5QLW6 10
organism: Macaca mulatta

uniprot P70174 142
type: UnificationXref
id: P70174
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
type: ProteinReference
xref: uniprot Q8R3B1 121
xref: PTHR10336:SF80
organism: Mus musculus

Protein kinase C-like 1
type: ProteinReference
xref: PTHR24356:SF347
xref: uniprot P34722 222
organism: Caenorhabditis elegans

GDP s10 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

EGL-30
type: ProteinReference
xref: uniprot G5EGU1 319
xref: PTHR10218:SF329
organism: Caenorhabditis elegans

uniprot P41743 224
type: UnificationXref
id: P41743
db: uniprot

uniprot P63214 373
type: UnificationXref
id: P63214
db: uniprot

ACTIVE 136
type: EntityFeature
comment: Active state

uniprot Q7QCP8 242
type: UnificationXref
id: Q7QCP8
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F7E2P1 60
organism: Monodelphis domestica

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot Q05513 234
organism: Homo sapiens

uniprot E2RJB3 272
type: UnificationXref
id: E2RJB3
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 297
organism: Macaca mulatta

uniprot B8JLJ7 260
type: UnificationXref
id: B8JLJ7
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F7H3B3 199
xref: PTHR24356:SF162
organism: Macaca mulatta

PTHR24247:SF223
type: RelationshipXref
id: PTHR24247:SF223
db: PANTHER Family
relationship type: By Homology

AGAP012252-PA (Fragment)
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot Q7Q042 241
organism: Anopheles gambiae

uniprot F6PVT7 286
type: UnificationXref
id: F6PVT7
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: uniprot H9EU39 204
xref: PTHR24356:SF365
organism: Macaca mulatta

uniprot R4GKD1 424
type: UnificationXref
id: R4GKD1
db: uniprot

uniprot O14610 331
type: UnificationXref
id: O14610
db: uniprot

ncbitaxon 3702 103
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot F6VQP7 152
type: UnificationXref
id: F6VQP7
db: uniprot

uniprot P29994 161
type: UnificationXref
id: P29994
db: uniprot

Protein kinase C alpha type
type: ProteinReference
xref: uniprot P17252 217
xref: PTHR24356:SF193
organism: Homo sapiens

uniprot Q6PBY0 407
type: UnificationXref
id: Q6PBY0
db: uniprot

uniprot F6TFY2 288
type: UnificationXref
id: F6TFY2
db: uniprot

G protein subunit beta 3
type: ProteinReference
xref: uniprot H2R3A6 326
organism: Pan troglodytes

DAG
type: SmallMolecule
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot Q9VXH3 133
organism: Drosophila melanogaster

uniprot F6Z8A1 54
type: UnificationXref
id: F6Z8A1
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot A0A2R8QJ48 174
organism: Danio rerio

uniprot Q90Z40 416
type: UnificationXref
id: Q90Z40
db: uniprot

uniprot P35367 141
type: UnificationXref
id: P35367
db: uniprot

uniprot A0A1D5Q4D0 9
type: UnificationXref
id: A0A1D5Q4D0
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

uniprot F6THW2 289
type: UnificationXref
id: F6THW2
db: uniprot

uniprot Q62074 239
type: UnificationXref
id: Q62074
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot Q8CIH5 117
organism: Mus musculus

uniprot E2R2S3 267
type: UnificationXref
id: E2R2S3
db: uniprot

uniprot Q6PH57 408
type: UnificationXref
id: Q6PH57
db: uniprot

ncbitaxon 9615 32
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot F1MYW8 278
type: UnificationXref
id: F1MYW8
db: uniprot

uniprot F7D5G3 59
type: UnificationXref
id: F7D5G3
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot A0A1D5Q4D0 9
organism: Macaca mulatta

ncbitaxon 227321 389
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot Q66JF0 401
type: UnificationXref
id: Q66JF0
db: uniprot

uniprot F6XHP0 293
type: UnificationXref
id: F6XHP0
db: uniprot

uniprot F1Q376 42
type: UnificationXref
id: F1Q376
db: uniprot

Histamine H1 receptor mediated signaling pathway
type: Pathway
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re18
pathway component: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_re26
pathway component: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_re21
pathway component: DISSOCIATION_LEFT__PIP2-RIGHT__DAG-_IP3-_re17
pathway component: DISSOCIATION_LEFT__Complex__H1_histamine__G_Protein_GDP_-_GTP-RIGHT__GDP-_Complex__GTP_G_Protein_-_Complex__H1_histamine_-_re30
pathway component: TRIGGER
pathway component: STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_re28
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__GDP_G_Protein__H1_-_histamine-RIGHT__Complex__H1_histamine__G_Protein_GDP_-_re31
xref: PANTHER Pathway P04385 1
comment: MODEL_NOTES=Panther Pathway: P04385 No pathway definition

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A0A096MJW8 3
xref: PTHR10336:SF51
organism: Rattus norvegicus

Ca2+
type: SmallMolecule
cellular location: Smooth Muscle trachea, ileum, uterus c3
comment: SPECIES_TYPE=ION

uniprot P16520 336
type: UnificationXref
id: P16520
db: uniprot

uniprot K7AE17 329
type: UnificationXref
id: K7AE17
db: uniprot

uniprot P05129 208
type: UnificationXref
id: P05129
db: uniprot

Histamine H1 receptor
type: ProteinReference
xref: uniprot P35367 141
xref: PTHR24247:SF223
organism: Homo sapiens

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q04759 233
xref: PTHR24356:SF181
organism: Homo sapiens

Protein kinase C
type: ProteinReference
xref: uniprot A0A3Q1MSP9 176
xref: PTHR24356:SF170
organism: Bos taurus

uniprot P50150 354
type: UnificationXref
id: P50150
db: uniprot

uniprot Q3USB7 105
type: UnificationXref
id: Q3USB7
db: uniprot

uniprot F7EBE7 305
type: UnificationXref
id: F7EBE7
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
type: ProteinReference
xref: uniprot P25455 87
organism: Drosophila melanogaster

uniprot A8KBH6 178
type: UnificationXref
id: A8KBH6
db: uniprot

Complex (GTP/G-Protein)
type: Complex
component stoichiometry: G Protein s5 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s4 sa3 STOICHIOMETRY ID COMPLEX
component: GTP
component: G-Protein
feature: COMPLEX BINDING FEATURE s59 a55 433
feature: COMPLEX BINDING FEATURE s59 a55 431
feature: ACTIVE 136
cellular location: Smooth Muscle trachea, ileum, uterus c3

uniprot Q9P212 130
type: UnificationXref
id: Q9P212
db: uniprot

uniprot P19174 86
type: UnificationXref
id: P19174
db: uniprot

uniprot P21278 339
type: UnificationXref
id: P21278
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ERP8 307
organism: Ornithorhynchus anatinus

G Protein s8 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6VPY1 291
organism: Ornithorhynchus anatinus

uniprot K6ZCJ5 328
type: UnificationXref
id: K6ZCJ5
db: uniprot

uniprot F6TAH0 50
type: UnificationXref
id: F6TAH0
db: uniprot

uniprot H2Q3W7 322
type: UnificationXref
id: H2Q3W7
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P36408 348
organism: Dictyostelium discoideum

uniprot O14775 332
type: UnificationXref
id: O14775
db: uniprot

uniprot F7CTP1 302
type: UnificationXref
id: F7CTP1
db: uniprot

ncbitaxon 10090 25
type: UnificationXref
id: 10090
db: ncbitaxon