uniprot Q28024 152
type: UnificationXref
id: Q28024
db: uniprot

ncbitaxon 5786 46
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot F7CXD0 76
type: UnificationXref
id: F7CXD0
db: uniprot

uniprot H2R3A6 96
type: UnificationXref
id: H2R3A6
db: uniprot

uniprot P12368 220
type: UnificationXref
id: P12368
db: uniprot

uniprot O60262 102
type: UnificationXref
id: O60262
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q5ZJ03 162
organism: Gallus gallus

G Protein s15 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

uniprot F7CFG8 74
type: UnificationXref
id: F7CFG8
db: uniprot

uniprot P51828 260
type: UnificationXref
id: P51828
db: uniprot

uniprot P17343 105
type: UnificationXref
id: P17343
db: uniprot

uniprot F6XVE6 65
type: UnificationXref
id: F6XVE6
db: uniprot

uniprot F1RE11 50
type: UnificationXref
id: F1RE11
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IFL6 21
organism: Bos taurus

uniprot P27791 229
type: UnificationXref
id: P27791
db: uniprot

G Protein s12 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot Q08462 262
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot F7FXA9 83
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63212 138
organism: Bos taurus

cimetidine (tagamet)
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot P29387 112
organism: Mus musculus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 12

P04489
type: UnificationXref
id: P04489
db: PANTHER Pathway Component

uniprot E2R9G5 39
type: UnificationXref
id: E2R9G5
db: uniprot

uniprot Q6R0H7 173
type: UnificationXref
id: Q6R0H7
db: uniprot

PRKACB isoform 3
type: ProteinReference
xref: uniprot H2R1G3 210
xref: PTHR24353:SF116
organism: Pan troglodytes

uniprot F7G7I9 85
type: UnificationXref
id: F7G7I9
db: uniprot

uniprot F6PV18 56
type: UnificationXref
id: F6PV18
db: uniprot

uniprot J9P702 97
type: UnificationXref
id: J9P702
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QZN8 95
organism: Pan troglodytes

uniprot P30671 114
type: UnificationXref
id: P30671
db: uniprot

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 158
organism: Danio rerio

uniprot Q7Q5C3 178
type: UnificationXref
id: Q7Q5C3
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 108

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re5
controller: cAMP

ncbitaxon 7668 250
type: UnificationXref
id: 7668
db: ncbitaxon

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 110

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 163
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P17612 225
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 133
organism: Homo sapiens

ncbitaxon 44689 116
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot Q6DGZ5 167
type: UnificationXref
id: Q6DGZ5
db: uniprot

ncbitaxon 7739 30
type: UnificationXref
id: 7739
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 132
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 130
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 131
organism: Homo sapiens

uniprot E2R2S3 36
type: UnificationXref
id: E2R2S3
db: uniprot

uniprot F1MYW8 47
type: UnificationXref
id: F1MYW8
db: uniprot

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot P62881 135
organism: Mus musculus

uniprot Q7PXP3 176
type: UnificationXref
id: Q7PXP3
db: uniprot

PTHR10218:SF212
type: RelationshipXref
id: PTHR10218:SF212
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 134
organism: Mus musculus

uniprot P63077 136
type: UnificationXref
id: P63077
db: uniprot

Protein kinase cAMP-activated catalytic subunit beta
type: ProteinReference
xref: uniprot F6T0T9 203
xref: PTHR24353:SF116
organism: Xenopus tropicalis

ncbitaxon 227321 157
type: UnificationXref
id: 227321
db: ncbitaxon

DISSOCIATION_LEFT__Complex__GDP_G_Protein__H2_histamine_-_GTP-RIGHT__Complex__GTP_G_Protein_-_GDP-_Complex__histamine_H2_-_re11
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 293
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 294
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 292
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 295
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 291
left: GTP
left: Complex (GDP/G-Protein/ H2/histamine)
interaction type: DISSOCIATION
right: GDP
right: Complex (histamine/H2)
right: Complex (GTP/G-Protein)

AC
type: ProteinReference
xref: P04492
standard name: adenylate cyclase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Histamine H2 receptor mediated signaling pathway.PROTEIN.GENERIC.AC
comment: ENTITY_REFERENCE_NOTES=Long Name: AC Synonym: adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclase Accession: P04492
member entity reference: Adenylate cyclase type 2
member entity reference: Adenylate cyclase
member entity reference: Adenylate cyclase type 7

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 289
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 290
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

P04492
type: UnificationXref
id: P04492
db: PANTHER Pathway Component

P04491
type: UnificationXref
id: P04491
db: PANTHER Pathway Component

P04490
type: UnificationXref
id: P04490
db: PANTHER Pathway Component

uniprot P29387 112
type: UnificationXref
id: P29387
db: uniprot

uniprot F7G3J2 84
type: UnificationXref
id: F7G3J2
db: uniprot

uniprot Q7Q6D4 181
type: UnificationXref
id: Q7Q6D4
db: uniprot

AGAP001506-PA
type: ProteinReference
xref: uniprot Q7PXP3 176
organism: Anopheles gambiae

uniprot E2RRD1 197
type: UnificationXref
id: E2RRD1
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 53

uniprot F6PVT7 57
type: UnificationXref
id: F6PVT7
db: uniprot

uniprot P63215 141
type: UnificationXref
id: P63215
db: uniprot

Histamine H2 receptor
type: ProteinReference
xref: uniprot P97292 11
xref: PTHR24247:SF210
organism: Mus musculus

uniprot Q61017 165
type: UnificationXref
id: Q61017
db: uniprot

uniprot H2QFK0 208
type: UnificationXref
id: H2QFK0
db: uniprot

PTHR10218:SF320
type: RelationshipXref
id: PTHR10218:SF320
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 129
organism: Bos taurus

Adenylate cyclase
type: ProteinReference
xref: uniprot F1LQT1 253
xref: PTHR45627:SF9
organism: Rattus norvegicus

uniprot P68182 235
type: UnificationXref
id: P68182
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 164
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot Q61017 165
organism: Mus musculus

Complex (GDP/G-Protein/ H2/histamine)
type: Complex
component stoichiometry: H2 s16 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s14 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: histamine s17 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s15 sa9 STOICHIOMETRY ID COMPLEX
component: histamine
component: G-Protein
component: GDP
component: H2
feature: COMPLEX BINDING FEATURE s99 a47 281
feature: COMPLEX BINDING FEATURE s99 a47 275
feature: COMPLEX BINDING FEATURE s99 a47 277
feature: COMPLEX BINDING FEATURE s99 a47 279
cellular location: cytosol

G protein subunit alpha L
type: ProteinReference
xref: uniprot A0A2I3SJ53 13
organism: Pan troglodytes

uniprot E1BW98 34
type: UnificationXref
id: E1BW98
db: uniprot

uniprot A8XW88 194
type: UnificationXref
id: A8XW88
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot F7CTP1 75
organism: Macaca mulatta

uniprot P34099 232
type: UnificationXref
id: P34099
db: uniprot

uniprot P05132 218
type: UnificationXref
id: P05132
db: uniprot

Guanine nucleotide binding protein, beta 3
type: ProteinReference
xref: uniprot Q5XGD8 161
organism: Xenopus tropicalis

uniprot Q3SZ98 155
type: UnificationXref
id: Q3SZ98
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 14

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 23

GTP s2 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: uniprot Q922R0 247
xref: PTHR24353:SF37
organism: Mus musculus

ncbitaxon 5664 199
type: UnificationXref
id: 5664
db: ncbitaxon

uniprot Q28H40 153
type: UnificationXref
id: Q28H40
db: uniprot

ncbitaxon 214684 160
type: UnificationXref
id: 214684
db: ncbitaxon

uniprot H9EQQ4 213
type: UnificationXref
id: H9EQQ4
db: uniprot

uniprot Q05337 146
type: UnificationXref
id: Q05337
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P68182 235
xref: PTHR24353:SF116
organism: Rattus norvegicus

Histamine H2 receptor
type: ProteinReference
xref: PTHR24247:SF210
xref: uniprot P25102 9
organism: Rattus norvegicus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P68181 234
xref: PTHR24353:SF116
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot O14610 100
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__histamine-_Complex__GDP_G_Protein__H2_-RIGHT__Complex__GDP_G_Protein__H2_histamine_-_re10
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 296
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 298
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 297
left: histamine
left: Complex (GDP/G-Protein/ H2)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GDP/G-Protein/ H2/histamine)

uniprot F7FXA9 83
type: UnificationXref
id: F7FXA9
db: uniprot

uniprot F7E427 77
type: UnificationXref
id: F7E427
db: uniprot

Guanine nucleotide-binding protein subunit beta-5a
type: ProteinReference
xref: uniprot A1L271 19
organism: Danio rerio

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P49177 119
organism: Arabidopsis thaliana

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZSF0 29
organism: Branchiostoma floridae

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa2 274
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7H6T2 206
type: UnificationXref
id: F7H6T2
db: uniprot

uniprot Q6DH55 168
type: UnificationXref
id: Q6DH55
db: uniprot

uniprot P50153 123
type: UnificationXref
id: P50153
db: uniprot

G Protein s3 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

uniprot F6XHP0 64
type: UnificationXref
id: F6XHP0
db: uniprot

uniprot F6SSS3 59
type: UnificationXref
id: F6SSS3
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 103
organism: Bos taurus

Protein kinase A catalytic subunit
type: ProteinReference
xref: uniprot Q27687 237
xref: PTHR24353:SF37
organism: Leishmania major

uniprot F7ERP8 80
type: UnificationXref
id: F7ERP8
db: uniprot

uniprot Q9GNR4 248
type: UnificationXref
id: Q9GNR4
db: uniprot

uniprot Q9HAV0 188
type: UnificationXref
id: Q9HAV0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot F7H6T2 206
organism: Macaca mulatta

uniprot P54311 126
type: UnificationXref
id: P54311
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T7 87
organism: Macaca mulatta

uniprot F6YZA3 68
type: UnificationXref
id: F6YZA3
db: uniprot

uniprot Q3ZB92 238
type: UnificationXref
id: Q3ZB92
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CB49 73
organism: Monodelphis domestica

uniprot P31323 230
type: UnificationXref
id: P31323
db: uniprot

By Homology
type: RelationshipTypeVocabulary

PTHR24247:SF210
type: RelationshipXref
id: PTHR24247:SF210
db: PANTHER Family
relationship type: By Homology

histamine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa3 284
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Protein kinase, cAMP-dependent, regulatory, type II, alpha, B
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot Q6NW93 241
organism: Danio rerio

Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
type: ProteinReference
xref: PTHR10218:SF320
xref: uniprot Q6R0H7 173
organism: Mus musculus

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 54
organism: Ornithorhynchus anatinus

uniprot F7CB49 73
type: UnificationXref
id: F7CB49
db: uniprot

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot F5HH30 52
organism: Neurospora crassa

uniprot A5PKD6 24
type: UnificationXref
id: A5PKD6
db: uniprot

Guanine nucleotide-binding protein G(olf) subunit alpha
type: ProteinReference
xref: uniprot Q8CGK7 184
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re6 299
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa5 266
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Protein kinase, X-linked
type: ProteinReference
xref: uniprot Q5BK52 239
xref: PTHR24353:SF37
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R9G5 39
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P43425 118
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IGZ2 22
organism: Xenopus tropicalis

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot O14775 101
organism: Homo sapiens

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

uniprot K7AEL3 214
type: UnificationXref
id: K7AEL3
db: uniprot

PARTICIPANT STOICHIOMETRY re6 300
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

uniprot Q9DAS9 187
type: UnificationXref
id: Q9DAS9
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q28024 152
organism: Bos taurus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XWE8 66
organism: Monodelphis domestica

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot P21137 226
xref: PTHR24353:SF117
organism: Caenorhabditis elegans

uniprot R4GKD1 192
type: UnificationXref
id: R4GKD1
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 38
organism: Canis lupus familiaris

uniprot F6W548 63
type: UnificationXref
id: F6W548
db: uniprot

PKA
type: Protein
entity reference: PKA
feature: ACTIVE 251
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q5BK52 239
type: UnificationXref
id: Q5BK52
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R2S3 36
organism: Canis lupus familiaris

uniprot H2RI77 212
type: UnificationXref
id: H2RI77
db: uniprot

uniprot P62881 135
type: UnificationXref
id: P62881
db: uniprot

uniprot Q20636 151
type: UnificationXref
id: Q20636
db: uniprot

AGAP005911-PA
type: ProteinReference
xref: uniprot Q7Q6D4 181
organism: Anopheles gambiae

GDP s14 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

AGAP005913-PA
type: ProteinReference
xref: uniprot Q7Q6D2 179
organism: Anopheles gambiae

AGAP005912-PA
type: ProteinReference
xref: uniprot Q7Q6D3 180
organism: Anopheles gambiae

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Bos taurus
type: BioSource
xref: ncbitaxon 9913 17

uniprot F7H6T7 87
type: UnificationXref
id: F7H6T7
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 4

Arachiodonic acid (AA)
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P11017 103
type: UnificationXref
id: P11017
db: uniprot

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
type: ProteinReference
xref: PTHR24353:SF135
xref: uniprot Q6DBV8 240
organism: Danio rerio

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 55

Protein kinase, cAMP-dependent, catalytic, beta a
type: ProteinReference
xref: uniprot Q7T374 245
xref: PTHR24353:SF116
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q3W7 92
organism: Pan troglodytes

uniprot E2RJB3 42
type: UnificationXref
id: E2RJB3
db: uniprot

uniprot P18851 107
type: UnificationXref
id: P18851
db: uniprot

PKA
type: Protein
entity reference: PKA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A3KMS9 193
type: UnificationXref
id: A3KMS9
db: uniprot

uniprot Q7KPV0 175
type: UnificationXref
id: Q7KPV0
db: uniprot

uniprot H2PZA6 90
type: UnificationXref
id: H2PZA6
db: uniprot

uniprot Q15KE4 150
type: UnificationXref
id: Q15KE4
db: uniprot

uniprot K7ADQ0 258
type: UnificationXref
id: K7ADQ0
db: uniprot

eco ECO:0000250 5
type: UnificationXref
id: ECO:0000250
db: eco

uniprot F1MJV4 254
type: UnificationXref
id: F1MJV4
db: uniprot

uniprot P62880 134
type: UnificationXref
id: P62880
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q28H40 153
organism: Xenopus tropicalis

PKA
type: ProteinReference
xref: P04491
standard name: Protein kinase A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Histamine H2 receptor mediated signaling pathway.PROTEIN.GENERIC.PKA
comment: ENTITY_REFERENCE_NOTES=Long Name: PKA Synonym: protein kinase A Accession: P04491
member entity reference: Uncharacterized protein
member entity reference: cAMP-dependent protein kinase catalytic subunit PRKX
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit beta
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha
member entity reference: Protein kinase, X-linked
member entity reference: cAMP-dependent protein kinase catalytic subunit 3
member entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha isoform 1
member entity reference: Protein kinase A catalytic subunit isoform 2
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
member entity reference: cAMP-dependent protein kinase catalytic subunit beta
member entity reference: Protein kinase cAMP-activated catalytic subunit beta
member entity reference: cAMP-dependent protein kinase catalytic subunit beta isoform 1
member entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit
member entity reference: AGAP001384-PA
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
member entity reference: AGAP004940-PA
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta
member entity reference: cAMP-dependent protein kinase catalytic subunit
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit alpha
member entity reference: Protein kinase A catalytic subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit 1
member entity reference: cAMP-dependent protein kinase type II regulatory subunit
member entity reference: Protein kinase cAMP-activated catalytic subunit alpha
member entity reference: Protein kinase A catalytic subunit isoform 1
member entity reference: Protein kinase, cAMP-dependent, regulatory, type II, alpha, B
member entity reference: PRKAR2A isoform 1
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta a
member entity reference: cAMP-dependent protein kinase catalytic subunit gamma
member entity reference: AGAP008039-PA (Fragment)
member entity reference: PRKACB isoform 3
member entity reference: PRKACG isoform 1

uniprot Q7T374 245
type: UnificationXref
id: Q7T374
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P30671 114
organism: Bos taurus

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P31324 231
xref: PTHR11635:SF156
organism: Mus musculus

Protein kinase cAMP-dependent type II regulatory subunit alpha
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot E2RRD1 197
organism: Canis lupus familiaris

G protein alpha s subunit
type: ProteinReference
xref: PTHR10218:SF212
xref: uniprot P20354 109
organism: Drosophila melanogaster

AGAP006521-PA
type: ProteinReference
xref: uniprot Q7Q5C3 178
organism: Anopheles gambiae

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 28

uniprot F6T0T9 203
type: UnificationXref
id: F6T0T9
db: uniprot

uniprot A7EDU2 25
type: UnificationXref
id: A7EDU2
db: uniprot

uniprot Q6PBY0 171
type: UnificationXref
id: Q6PBY0
db: uniprot

uniprot P05131 217
type: UnificationXref
id: P05131
db: uniprot

DISSOCIATION
type: RelationshipTypeVocabulary

uniprot P97292 11
type: UnificationXref
id: P97292
db: uniprot

AGAP008039-PA (Fragment)
type: ProteinReference
xref: uniprot Q7Q3T7 244
xref: PTHR24353:SF117
organism: Anopheles gambiae

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot A8XW88 194
organism: Caenorhabditis briggsae

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot F1A421 45
organism: Dictyostelium purpureum

cAMP-dependent protein kinase catalytic subunit 1
type: ProteinReference
xref: uniprot P12370 222
xref: PTHR24353:SF117
organism: Drosophila melanogaster

uniprot G3V6P8 88
type: UnificationXref
id: G3V6P8
db: uniprot

Histamine receptor H2
type: ProteinReference
xref: PTHR24247:SF210
xref: uniprot F7C4E6 3
organism: Macaca mulatta

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 37

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NGS8 18
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50150 121
organism: Homo sapiens

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 94
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot P50151 122
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7G7I9 85
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot P50154 124
organism: Bos taurus

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot Q80TL1 264
organism: Mus musculus

uniprot F7DL70 257
type: UnificationXref
id: F7DL70
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50153 123
organism: Mus musculus

INHIBITION
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__histamine-_Complex__GDP_G_Protein__H2_-RIGHT__Complex__GDP_G_Protein__H2_histamine_-_re10
control type: INHIBITION
controller: cimetidine (tagamet)

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P31323 230
xref: PTHR11635:SF156
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1M3D6 16
organism: Bos taurus

uniprot Q5XGD8 161
type: UnificationXref
id: Q5XGD8
db: uniprot

uniprot P59768 128
type: UnificationXref
id: P59768
db: uniprot

uniprot P43425 118
type: UnificationXref
id: P43425
db: uniprot

ncbitaxon 6239 106
type: UnificationXref
id: 6239
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7CFG8 74
organism: Monodelphis domestica

uniprot P12370 222
type: UnificationXref
id: P12370
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 33

ncbitaxon 284812 149
type: UnificationXref
id: 284812
db: ncbitaxon

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P12369 221
xref: PTHR11635:SF156
organism: Rattus norvegicus

uniprot Q6DBV8 240
type: UnificationXref
id: Q6DBV8
db: uniprot

uniprot F1A421 45
type: UnificationXref
id: F1A421
db: uniprot

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: uniprot P12367 219
xref: PTHR11635:SF153
organism: Mus musculus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P12368 220
organism: Rattus norvegicus

Adenylate cyclase type 7
type: ProteinReference
xref: uniprot P51828 260
xref: PTHR45627:SF9
organism: Homo sapiens

uniprot H2R1G3 210
type: UnificationXref
id: H2R1G3
db: uniprot

uniprot P25102 9
type: UnificationXref
id: P25102
db: uniprot

ncbitaxon 7227 110
type: UnificationXref
id: 7227
db: ncbitaxon

STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 299
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 300
left: AC
interaction type: STATE_TRANSITION
right: AC

uniprot F2Z3T8 51
type: UnificationXref
id: F2Z3T8
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7GI54 86
organism: Monodelphis domestica

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot P51829 261
organism: Mus musculus

uniprot P63218 144
type: UnificationXref
id: P63218
db: uniprot

ncbitaxon 3702 120
type: UnificationXref
id: 3702
db: ncbitaxon

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P27791 229
xref: PTHR24353:SF82
organism: Rattus norvegicus

uniprot P50150 121
type: UnificationXref
id: P50150
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

Gnb3 protein
type: ProteinReference
xref: uniprot Q6P025 169
organism: Danio rerio

uniprot P21137 226
type: UnificationXref
id: P21137
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot K7ADQ0 258
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V6P8 88
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5KI86 159
organism: Cryptococcus neoformans

Guanine nucleotide binding protein, beta subunit
type: ProteinReference
xref: uniprot E9FUX0 43
organism: Daphnia pulex

uniprot F7EJA3 79
type: UnificationXref
id: F7EJA3
db: uniprot

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: PTHR24353:SF133
xref: uniprot P51817 233
organism: Homo sapiens

uniprot P31324 231
type: UnificationXref
id: P31324
db: uniprot

uniprot Q3KRE3 154
type: UnificationXref
id: Q3KRE3
db: uniprot

uniprot P54313 127
type: UnificationXref
id: P54313
db: uniprot

uniprot H2Q1D9 91
type: UnificationXref
id: H2Q1D9
db: uniprot

G protein, Subunit Alpha
type: ProteinReference
xref: uniprot Q7KPV0 175
organism: Caenorhabditis elegans

uniprot Q61011 163
type: UnificationXref
id: Q61011
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot H2Q9G5 93
organism: Pan troglodytes

uniprot Q29450 263
type: UnificationXref
id: Q29450
db: uniprot

uniprot F6ZDB2 69
type: UnificationXref
id: F6ZDB2
db: uniprot

uniprot P17612 225
type: UnificationXref
id: P17612
db: uniprot

uniprot Q7PXF7 243
type: UnificationXref
id: Q7PXF7
db: uniprot

uniprot P20354 109
type: UnificationXref
id: P20354
db: uniprot

H2
type: Protein
entity reference: H2
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa7 270
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P63214 140
type: UnificationXref
id: P63214
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9UBI6 189
organism: Homo sapiens

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot Q29450 263
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF320
xref: uniprot F6PV18 56
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63219 145
organism: Rattus norvegicus

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot F6Q503 201
xref: PTHR11635:SF156
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 144
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63217 143
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 57
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63216 142
organism: Mus musculus

H2
type: Protein
entity reference: H2
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa4 286
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 141
organism: Homo sapiens

uniprot E9GNI4 200
type: UnificationXref
id: E9GNI4
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63214 140
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63213 139
organism: Mus musculus

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 195

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 67
organism: Monodelphis domestica

THO complex subunit, putative
type: ProteinReference
xref: uniprot B7Q3T6 27
organism: Ixodes scapularis

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q15KE4 150
organism: Danio rerio

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 106

uniprot Q10282 148
type: UnificationXref
id: Q10282
db: uniprot

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: PTHR11635:SF162
xref: uniprot P81900 236
organism: Drosophila melanogaster

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: uniprot P22612 227
xref: PTHR24353:SF137
organism: Homo sapiens

H2 s9 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: H2
stoichiometric coefficient: 1.0

uniprot F1PJE5 49
type: UnificationXref
id: F1PJE5
db: uniprot

uniprot Q5KI86 159
type: UnificationXref
id: Q5KI86
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XHP0 64
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BS74 32
organism: Gallus gallus

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot P29829 113
organism: Drosophila melanogaster

uniprot Q27687 237
type: UnificationXref
id: Q27687
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9DAS9 187
organism: Mus musculus

uniprot A0A2I3SJ53 13
type: UnificationXref
id: A0A2I3SJ53
db: uniprot

GTP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P62879 133
type: UnificationXref
id: P62879
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7F580 82
organism: Macaca mulatta

uniprot P29829 113
type: UnificationXref
id: P29829
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ASR8 71
organism: Macaca mulatta

H2
type: Protein
entity reference: H2
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa10 280
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot Q9CXP8 186
organism: Mus musculus

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P26308 111
organism: Drosophila melanogaster

uniprot P62873 131
type: UnificationXref
id: P62873
db: uniprot

PARTICIPANT STOICHIOMETRY re10 297
type: Stoichiometry
physical entity: Complex (GDP/G-Protein/ H2)
stoichiometric coefficient: 1.0

uniprot Q8MJ44 246
type: UnificationXref
id: Q8MJ44
db: uniprot

PARTICIPANT STOICHIOMETRY re10 296
type: Stoichiometry
physical entity: histamine
stoichiometric coefficient: 1.0

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot F6Q9S4 202
xref: PTHR11635:SF156
organism: Bos taurus

uniprot O14775 101
type: UnificationXref
id: O14775
db: uniprot

ncbitaxon 9615 37
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot Q803H5 182
type: UnificationXref
id: Q803H5
db: uniprot

uniprot P16912 224
type: UnificationXref
id: P16912
db: uniprot

uniprot F7G4Q0 205
type: UnificationXref
id: F7G4Q0
db: uniprot

PARTICIPANT STOICHIOMETRY re10 298
type: Stoichiometry
physical entity: Complex (GDP/G-Protein/ H2/histamine)
stoichiometric coefficient: 1.0

uniprot E2RHY4 41
type: UnificationXref
id: E2RHY4
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RGI5 40
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CXD0 76
organism: Monodelphis domestica

uniprot F6VPY1 62
type: UnificationXref
id: F6VPY1
db: uniprot

G-protein beta subunit
type: ProteinReference
xref: uniprot Q5BH99 156
organism: Emericella nidulans

uniprot E1BS74 32
type: UnificationXref
id: E1BS74
db: uniprot

uniprot H2QNS5 94
type: UnificationXref
id: H2QNS5
db: uniprot

Protein kinase cAMP-activated catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H2QFK0 208
organism: Pan troglodytes

ncbitaxon 9598 14
type: UnificationXref
id: 9598
db: ncbitaxon

cAMP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A3Q1NGS8 18
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

uniprot H2QZN8 95
type: UnificationXref
id: H2QZN8
db: uniprot

H2 s16 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: H2
stoichiometric coefficient: 1.0

uniprot K7AE17 98
type: UnificationXref
id: K7AE17
db: uniprot

uniprot Q0VFC4 147
type: UnificationXref
id: Q0VFC4
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 177

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: uniprot W4YRI6 249
xref: PTHR11635:SF162
organism: Strongylocentrotus purpuratus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 47
organism: Bos taurus

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot H2RER5 211
organism: Pan troglodytes

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 26

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 160

uniprot Q08462 262
type: UnificationXref
id: Q08462
db: uniprot

ncbitaxon 10090 12
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot E1C795 35
type: UnificationXref
id: E1C795
db: uniprot

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P17343 105
organism: Caenorhabditis elegans

ncbitaxon 665079 26
type: UnificationXref
id: 665079
db: ncbitaxon

uniprot Q80TL1 264
type: UnificationXref
id: Q80TL1
db: uniprot

PTHR24353:SF133
type: RelationshipXref
id: PTHR24353:SF133
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re4 289
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot P26769 259
organism: Rattus norvegicus

uniprot P12367 219
type: UnificationXref
id: P12367
db: uniprot

PTHR24353:SF137
type: RelationshipXref
id: PTHR24353:SF137
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF135
type: RelationshipXref
id: PTHR24353:SF135
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF67
type: RelationshipXref
id: PTHR24353:SF67
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3SZ98 155
organism: Bos taurus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7BB02 72
organism: Macaca mulatta

uniprot D3ZLD6 31
type: UnificationXref
id: D3ZLD6
db: uniprot

uniprot A0A3Q1M3D6 16
type: UnificationXref
id: A0A3Q1M3D6
db: uniprot

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 182
organism: Danio rerio

G protein subunit alpha L
type: ProteinReference
xref: uniprot F6XVE6 65
organism: Xenopus tropicalis

uniprot Q7Q6D2 179
type: UnificationXref
id: Q7Q6D2
db: uniprot

uniprot F7ES96 81
type: UnificationXref
id: F7ES96
db: uniprot

uniprot O14610 100
type: UnificationXref
id: O14610
db: uniprot

PARTICIPANT STOICHIOMETRY re11 292
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 287
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 291
type: Stoichiometry
physical entity: Complex (GDP/G-Protein/ H2/histamine)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 288
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

uniprot P62871 129
type: UnificationXref
id: P62871
db: uniprot

PARTICIPANT STOICHIOMETRY re11 294
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 293
type: Stoichiometry
physical entity: Complex (GTP/G-Protein)
stoichiometric coefficient: 1.0

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 30

PARTICIPANT STOICHIOMETRY re11 295
type: Stoichiometry
physical entity: Complex (histamine/H2)
stoichiometric coefficient: 1.0

uniprot W4YRI6 249
type: UnificationXref
id: W4YRI6
db: uniprot

uniprot P22694 228
type: UnificationXref
id: P22694
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6SSS3 59
organism: Monodelphis domestica

prostaglandin secretion/mucosal defense
type: Pathway

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q1D9 91
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6W548 63
organism: Macaca mulatta

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: prostaglandin secretion/mucosal defense
controller: Arachiodonic acid (AA)

uniprot E2RRA1 196
type: UnificationXref
id: E2RRA1
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: gastric acid secretion
controller: PKA

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa9 278
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 5

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P52287 125
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3KRE3 154
organism: Rattus norvegicus

uniprot F7CTP1 75
type: UnificationXref
id: F7CTP1
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot E2RHY4 41
organism: Canis lupus familiaris

GDP s11 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P00515 215
organism: Bos taurus

uniprot F7HAK5 207
type: UnificationXref
id: F7HAK5
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P00517 216
xref: PTHR24353:SF82
organism: Bos taurus

PTHR24353:SF128
type: RelationshipXref
id: PTHR24353:SF128
db: PANTHER Family
relationship type: By Homology

uniprot F7ASR8 71
type: UnificationXref
id: F7ASR8
db: uniprot

Complex (GTP/G-Protein)
type: Complex
component stoichiometry: GTP s2 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s3 sa2 STOICHIOMETRY ID COMPLEX
component: G-Protein
component: GTP
feature: COMPLEX BINDING FEATURE s6 a6 271
feature: ACTIVE 251
feature: COMPLEX BINDING FEATURE s6 a6 273
cellular location: cytosol

tiotidine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot O60262 102
organism: Homo sapiens

uniprot E9AFM1 198
type: UnificationXref
id: E9AFM1
db: uniprot

PTHR24353:SF82
type: RelationshipXref
id: PTHR24353:SF82
db: PANTHER Family
relationship type: By Homology

histamine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa11 282
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 58

Complex (histamine/H2)
type: Complex
component stoichiometry: H2 s9 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: histamine s7 sa3 STOICHIOMETRY ID COMPLEX
component: H2
component: histamine
feature: COMPLEX BINDING FEATURE s19 a26 283
feature: COMPLEX BINDING FEATURE s19 a26 285
cellular location: cytosol

uniprot P13861 223
type: UnificationXref
id: P13861
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7AE17 98
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot D3ZLD6 31
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 34
organism: Gallus gallus

uniprot F6Q9S4 202
type: UnificationXref
id: F6Q9S4
db: uniprot

uniprot E2R2S8 38
type: UnificationXref
id: E2R2S8
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__histamine-_Complex__GDP_G_Protein__H2_-RIGHT__Complex__GDP_G_Protein__H2_histamine_-_re10
control type: INHIBITION
controller: tiotidine

PTHR24353:SF117
type: RelationshipXref
id: PTHR24353:SF117
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF116
type: RelationshipXref
id: PTHR24353:SF116
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF37
type: RelationshipXref
id: PTHR24353:SF37
db: PANTHER Family
relationship type: By Homology

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 149

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot A3KMS9 193
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF128
xref: uniprot H2RI77 212
organism: Pan troglodytes

ncbitaxon 6945 28
type: UnificationXref
id: 6945
db: ncbitaxon

uniprot P26769 259
type: UnificationXref
id: P26769
db: uniprot

STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 288
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 287
left: PKA
interaction type: STATE_TRANSITION
right: PKA

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 84
organism: Monodelphis domestica

H2 s13 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: H2
stoichiometric coefficient: 1.0

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot A0A1D5RHE7 252
organism: Macaca mulatta

uniprot Q90Z40 185
type: UnificationXref
id: Q90Z40
db: uniprot

AGAP004940-PA
type: ProteinReference
xref: uniprot Q7PPI8 242
xref: PTHR11635:SF162
organism: Anopheles gambiae

PTHR11635:SF162
type: RelationshipXref
id: PTHR11635:SF162
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

uniprot Q80SZ7 183
type: UnificationXref
id: Q80SZ7
db: uniprot

ncbitaxon 10116 10
type: UnificationXref
id: 10116
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q0VFC4 147
organism: Xenopus tropicalis

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DF43 166
organism: Xenopus tropicalis

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P05132 218
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6TH03 174
organism: Danio rerio

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P05131 217
xref: PTHR24353:SF116
organism: Bos taurus

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot Q20636 151
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 188
organism: Homo sapiens

H2
type: ProteinReference
xref: P04489
standard name: Histamine H2 receptor
comment: ENTITY_REFERENCE_ID_DESC=Histamine H2 receptor mediated signaling pathway.PROTEIN.RECEPTOR.H2
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Histamine H2 receptor
member entity reference: Histamine receptor H2

uniprot F6XWE8 66
type: UnificationXref
id: F6XWE8
db: uniprot

uniprot A0A2I3TUD1 15
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

GNB4 protein
type: ProteinReference
xref: uniprot A5PKD6 24
organism: Bos taurus

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 8

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa6 268
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot Q10282 148
organism: Schizosaccharomyces pombe

uniprot Q5BH99 156
type: UnificationXref
id: Q5BH99
db: uniprot

Guanine nucleotide-binding protein G(olf) subunit alpha
type: ProteinReference
xref: uniprot P38405 117
organism: Homo sapiens

PTHR11635:SF156
type: RelationshipXref
id: PTHR11635:SF156
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF153
type: RelationshipXref
id: PTHR11635:SF153
db: PANTHER Family
relationship type: By Homology

uniprot Q5BJ11 158
type: UnificationXref
id: Q5BJ11
db: uniprot

uniprot F7C4E6 3
type: UnificationXref
id: F7C4E6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RJB3 42
organism: Canis lupus familiaris

uniprot F6Y3N2 67
type: UnificationXref
id: F6Y3N2
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 120

uniprot Q7Q3T7 244
type: UnificationXref
id: Q7Q3T7
db: uniprot

uniprot P26308 111
type: UnificationXref
id: P26308
db: uniprot

uniprot A1L271 19
type: UnificationXref
id: A1L271
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha isoform 1
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H9EQQ4 213
organism: Macaca mulatta

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P18851 107
organism: Saccharomyces cerevisiae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re6
controller: Complex (GTP/G-Protein)

uniprot Q6P025 169
type: UnificationXref
id: Q6P025
db: uniprot

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot E2RRA1 196
xref: PTHR11635:SF156
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit beta-5b
type: ProteinReference
xref: uniprot Q6PBY0 171
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HAK5 207
xref: PTHR11635:SF153
organism: Macaca mulatta

uniprot Q5ZJ03 162
type: UnificationXref
id: Q5ZJ03
db: uniprot

Gbeta5
type: ProteinReference
xref: uniprot Q9W3J1 191
organism: Drosophila melanogaster

G protein subunit gamma 5
type: ProteinReference
xref: uniprot H2PZA6 90
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1PJE5 49
organism: Canis lupus familiaris

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 250

ncbitaxon 9258 55
type: UnificationXref
id: 9258
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re4 290
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

uniprot A0A1D5RHE7 252
type: UnificationXref
id: A0A1D5RHE7
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P22694 228
xref: PTHR24353:SF116
organism: Homo sapiens

uniprot C3ZSF0 29
type: UnificationXref
id: C3ZSF0
db: uniprot

ncbitaxon 6238 195
type: UnificationXref
id: 6238
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot Q9UK08 190
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E1C795 35
organism: Gallus gallus

uniprot H2Q9G5 93
type: UnificationXref
id: H2Q9G5
db: uniprot

histamine s7 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: histamine
stoichiometric coefficient: 1.0

uniprot P49177 119
type: UnificationXref
id: P49177
db: uniprot

PRKAR2A isoform 1
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot K7AEL3 214
organism: Pan troglodytes

Danio rerio
type: BioSource
xref: ncbitaxon 7955 20

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot R4GKD1 192
organism: Gallus gallus

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot Q8MJ44 246
organism: Canis lupus familiaris

uniprot P68181 234
type: UnificationXref
id: P68181
db: uniprot

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P13861 223
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 81
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot E9GNI4 200
xref: PTHR24353:SF117
organism: Daphnia pulex

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NLV4 48
organism: Gallus gallus

uniprot A4IFL6 21
type: UnificationXref
id: A4IFL6
db: uniprot

Complex (GDP/G-Protein/ H2)
type: Complex
component stoichiometry: GDP s11 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s12 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: H2 s13 sa7 STOICHIOMETRY ID COMPLEX
component: GDP
component: H2
component: G-Protein
feature: COMPLEX BINDING FEATURE s94 a41 265
feature: COMPLEX BINDING FEATURE s94 a41 267
feature: COMPLEX BINDING FEATURE s94 a41 269
cellular location: cytosol

uniprot E9FUX0 43
type: UnificationXref
id: E9FUX0
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V8K2 89
organism: Rattus norvegicus

uniprot F5HH30 52
type: UnificationXref
id: F5HH30
db: uniprot

uniprot P50154 124
type: UnificationXref
id: P50154
db: uniprot

ncbitaxon 8364 23
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot G3V8K2 89
type: UnificationXref
id: G3V8K2
db: uniprot

uniprot P63217 143
type: UnificationXref
id: P63217
db: uniprot

uniprot P50151 122
type: UnificationXref
id: P50151
db: uniprot

AGAP001384-PA
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot Q7PXF7 243
organism: Anopheles gambiae

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa8 276
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 15
organism: Pan troglodytes

ncbitaxon 9606 8
type: UnificationXref
id: 9606
db: ncbitaxon

ncbitaxon 6669 44
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot P51817 233
type: UnificationXref
id: P51817
db: uniprot

uniprot Q6PH57 172
type: UnificationXref
id: Q6PH57
db: uniprot

Guanine nucleotide-binding protein G(f) subunit alpha
type: ProteinReference
xref: uniprot Q05337 146
organism: Drosophila melanogaster

uniprot P63216 142
type: UnificationXref
id: P63216
db: uniprot

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot A7EDU2 25
organism: Sclerotinia sclerotiorum

uniprot Q6NW93 241
type: UnificationXref
id: Q6NW93
db: uniprot

PANTHER Pathway P04386 1
type: UnificationXref
id: P04386
db: PANTHER Pathway

Guanine nucleotide-binding protein (G protein), alpha-activating activity polypeptide, olfactory type
type: ProteinReference
xref: uniprot F1RE11 50
organism: Danio rerio

uniprot B7Q3T6 27
type: UnificationXref
id: B7Q3T6
db: uniprot

uniprot Q6PBR4 170
type: UnificationXref
id: Q6PBR4
db: uniprot

Histamine H2 receptor
type: ProteinReference
xref: uniprot P25021 7
xref: PTHR24247:SF210
organism: Homo sapiens

uniprot Q9CXP8 186
type: UnificationXref
id: Q9CXP8
db: uniprot

AC
type: Protein
entity reference: AC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 68
organism: Monodelphis domestica

uniprot K7E376 99
type: UnificationXref
id: K7E376
db: uniprot

PTHR45627:SF9
type: RelationshipXref
id: PTHR45627:SF9
db: PANTHER Family
relationship type: By Homology

uniprot F6ZAV4 256
type: UnificationXref
id: F6ZAV4
db: uniprot

PTHR45627:SF6
type: RelationshipXref
id: PTHR45627:SF6
db: PANTHER Family
relationship type: By Homology

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 116

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F2Z3T8 51
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot F6V461 61
type: UnificationXref
id: F6V461
db: uniprot

uniprot Q8CGK7 184
type: UnificationXref
id: Q8CGK7
db: uniprot

uniprot P51829 261
type: UnificationXref
id: P51829
db: uniprot

uniprot P22612 227
type: UnificationXref
id: P22612
db: uniprot

ncbitaxon 9544 4
type: UnificationXref
id: 9544
db: ncbitaxon

gastric acid secretion
type: Pathway

ncbitaxon 7165 177
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot E2RGI5 40
type: UnificationXref
id: E2RGI5
db: uniprot

uniprot P63219 145
type: UnificationXref
id: P63219
db: uniprot

uniprot P00517 216
type: UnificationXref
id: P00517
db: uniprot

uniprot P00515 215
type: UnificationXref
id: P00515
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7E376 99
organism: Monodelphis domestica

Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
type: ProteinReference
xref: uniprot Q6DH55 168
organism: Danio rerio

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 183
organism: Mus musculus

uniprot P62874 132
type: UnificationXref
id: P62874
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6TFY2 60
organism: Macaca mulatta

uniprot F1LQT1 253
type: UnificationXref
id: F1LQT1
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q90Z40 185
organism: Danio rerio

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re4
controller: AC

uniprot F7GI54 86
type: UnificationXref
id: F7GI54
db: uniprot

uniprot F6Q503 201
type: UnificationXref
id: F6Q503
db: uniprot

uniprot Q9UK08 190
type: UnificationXref
id: Q9UK08
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 10

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 70
organism: Macaca mulatta

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa1 272
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q6DF43 166
type: UnificationXref
id: Q6DF43
db: uniprot

uniprot H2RER5 211
type: UnificationXref
id: H2RER5
db: uniprot

uniprot F7EBE7 78
type: UnificationXref
id: F7EBE7
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 44

INHIBITION
type: RelationshipTypeVocabulary

histamine s17 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: histamine
stoichiometric coefficient: 1.0

uniprot P63213 139
type: UnificationXref
id: P63213
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__histamine-_Complex__GDP_G_Protein__H2_-RIGHT__Complex__GDP_G_Protein__H2_histamine_-_re10
control type: INHIBITION
controller: ranitidine (zantac)

ncbitaxon 9031 33
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot F7EBQ5 204
type: UnificationXref
id: F7EBQ5
db: uniprot

uniprot Q9W3J1 191
type: UnificationXref
id: Q9W3J1
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63078 137
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 136
organism: Rattus norvegicus

Protein kinase A catalytic subunit isoform 2
type: ProteinReference
xref: uniprot E9AFM1 198
xref: PTHR24353:SF67
organism: Leishmania major

uniprot F6ZIZ9 70
type: UnificationXref
id: F6ZIZ9
db: uniprot

G protein subunit beta 3
type: ProteinReference
xref: uniprot H2R3A6 96
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 127
organism: Rattus norvegicus

Adenylate cyclase
type: ProteinReference
xref: uniprot F6ZAV4 256
xref: PTHR45627:SF6
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 126
organism: Rattus norvegicus

uniprot P62872 130
type: UnificationXref
id: P62872
db: uniprot

ncbitaxon 7955 20
type: UnificationXref
id: 7955
db: ncbitaxon

ncbitaxon 9913 17
type: UnificationXref
id: 9913
db: ncbitaxon

STATE_TRANSITION
type: InteractionVocabulary

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 77
organism: Ornithorhynchus anatinus

uniprot Q922R0 247
type: UnificationXref
id: Q922R0
db: uniprot

ncbitaxon 13616 58
type: UnificationXref
id: 13616
db: ncbitaxon

ACTIVE 251
type: EntityFeature
comment: Active state

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot F6V001 255
organism: Monodelphis domestica

uniprot P81900 236
type: UnificationXref
id: P81900
db: uniprot

uniprot P63078 137
type: UnificationXref
id: P63078
db: uniprot

G-Protein
type: ProteinReference
xref: P04490
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Histamine H2 receptor mediated signaling pathway.PROTEIN.GENERIC.G-Protein
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Guanine nucleotide-binding protein subunit beta-5a
member entity reference: AGAP005913-PA
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: THO complex subunit, putative
member entity reference: G protein subunit beta 3
member entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
member entity reference: Guanine nucleotide binding protein, beta subunit
member entity reference: Guanine nucleotide-binding protein (G protein), beta 5
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein beta subunit
member entity reference: G protein subunit beta 1
member entity reference: G protein subunit beta 4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: Guanine nucleotide binding protein, beta 3
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
member entity reference: Guanine nucleotide-binding protein subunit beta-5b
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: Guanine nucleotide-binding protein subunit beta-1
member entity reference: GNB4 protein
member entity reference: Guanine nucleotide-binding protein subunit beta-5
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
member entity reference: G protein subunit beta 2
member entity reference: AGAP005911-PA
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
member entity reference: Gnb3 protein
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
member entity reference: Gnb2 protein
member entity reference: G protein alpha s subunit
member entity reference: Guanine nucleotide-binding protein G(f) subunit alpha
member entity reference: AGAP005912-PA

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot F7G4Q0 205
organism: Monodelphis domestica

PRKACG isoform 1
type: ProteinReference
xref: uniprot H2QXB9 209
xref: PTHR24353:SF137
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 172
organism: Danio rerio

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot F1MJV4 254
organism: Bos taurus

uniprot Q9UBI6 189
type: UnificationXref
id: Q9UBI6
db: uniprot

uniprot P63212 138
type: UnificationXref
id: P63212
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 46

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot F7DL70 257
organism: Macaca mulatta

GDP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7BB02 72
type: UnificationXref
id: F7BB02
db: uniprot

Histamine H2 receptor mediated signaling pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re5
pathway component: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re6
pathway component: PHYSICAL_STIMULATION
pathway component: HETERODIMER_ASSOCIATION_LEFT__histamine-_Complex__GDP_G_Protein__H2_-RIGHT__Complex__GDP_G_Protein__H2_histamine_-_re10
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re4
pathway component: DISSOCIATION_LEFT__Complex__GDP_G_Protein__H2_histamine_-_GTP-RIGHT__Complex__GTP_G_Protein_-_GDP-_Complex__histamine_H2_-_re11
xref: PANTHER Pathway P04386 1
comment: MODEL_NOTES=Panther Pathway: P04386 No pathway definition

Leishmania major
type: BioSource
xref: ncbitaxon 5664 199

uniprot Q6TH03 174
type: UnificationXref
id: Q6TH03
db: uniprot

ncbitaxon 367110 53
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot Q7Q6D3 180
type: UnificationXref
id: Q7Q6D3
db: uniprot

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

ranitidine (zantac)
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7F580 82
type: UnificationXref
id: F7F580
db: uniprot

uniprot H2QXB9 209
type: UnificationXref
id: H2QXB9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZDB2 69
xref: PTHR10218:SF320
organism: Monodelphis domestica

uniprot H2Q3W7 92
type: UnificationXref
id: H2Q3W7
db: uniprot

uniprot P16520 104
type: UnificationXref
id: P16520
db: uniprot

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot P34099 232
xref: PTHR24353:SF37
organism: Dictyostelium discoideum

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot F1NLV4 48
type: UnificationXref
id: F1NLV4
db: uniprot

cAMP-dependent protein kinase catalytic subunit 3
type: ProteinReference
xref: uniprot P16912 224
xref: PTHR24353:SF37
organism: Drosophila melanogaster

uniprot A4IGZ2 22
type: UnificationXref
id: A4IGZ2
db: uniprot

uniprot P36408 115
type: UnificationXref
id: P36408
db: uniprot

histamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q61016 164
type: UnificationXref
id: Q61016
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ERP8 80
organism: Ornithorhynchus anatinus

uniprot F6TFY2 60
type: UnificationXref
id: F6TFY2
db: uniprot

uniprot P25021 7
type: UnificationXref
id: P25021
db: uniprot

Guanine nucleotide-binding protein (G protein), beta 5
type: ProteinReference
xref: uniprot F7EBE7 78
organism: Xenopus tropicalis

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6VPY1 62
organism: Ornithorhynchus anatinus

uniprot Q7PPI8 242
type: UnificationXref
id: Q7PPI8
db: uniprot

uniprot F6V001 255
type: UnificationXref
id: F6V001
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6V461 61
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P16520 104
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P59768 128
organism: Homo sapiens

AC
type: Protein
entity reference: AC
feature: ACTIVE 251
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P36408 115
organism: Dictyostelium discoideum

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EJA3 79
xref: PTHR10218:SF320
organism: Ornithorhynchus anatinus

uniprot P38405 117
type: UnificationXref
id: P38405
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 157

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6PBR4 170
organism: Danio rerio

Protein kinase, cAMP-dependent, catalytic, beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot Q3ZB92 238
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DGZ5 167
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot J9P702 97
organism: Canis lupus familiaris

uniprot P12369 221
type: UnificationXref
id: P12369
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta isoform 1
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot F7EBQ5 204
organism: Macaca mulatta

Protein kinase A catalytic subunit isoform 1
type: ProteinReference
xref: uniprot Q9GNR4 248
xref: PTHR24353:SF67
organism: Leishmania major

uniprot F6PGC8 54
type: UnificationXref
id: F6PGC8
db: uniprot

ncbitaxon 559292 108
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot P52287 125
type: UnificationXref
id: P52287
db: uniprot