Histamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

pyridoxal phosphate (vitamin B6)
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9615 7
type: UnificationXref
id: 9615
db: ncbitaxon

ncbitaxon 9913 19
type: UnificationXref
id: 9913
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re1 22
type: Stoichiometry
physical entity: Histidine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 23
type: Stoichiometry
physical entity: CO2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 24
type: Stoichiometry
physical entity: Histamine
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Histidine-RIGHT__CO2-_Histamine-_re1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 22
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 23
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 24
left: Histidine
interaction type: STATE_TRANSITION
right: CO2
right: Histamine

Histidine decarboxylase
type: Protein
entity reference: Histidine Decarboxylase
comment: SPECIES_TYPE=PROTEIN

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 9

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 21

PANTHER Pathway P04387 1
type: UnificationXref
id: P04387
db: PANTHER Pathway

Histidine decarboxylase
type: ProteinReference
xref: PTHR11999:SF68
xref: uniprot E2RMU1 6
organism: Canis lupus familiaris

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

AGAP009001-PA (Fragment)
type: ProteinReference
xref: uniprot Q7PWE0 20
xref: PTHR11999:SF68
organism: Anopheles gambiae

uniprot P19113 12
type: UnificationXref
id: P19113
db: uniprot

ncbitaxon 10090 15
type: UnificationXref
id: 10090
db: ncbitaxon

Histidine decarboxylase
type: ProteinReference
xref: PTHR11999:SF68
xref: uniprot P19113 12
organism: Homo sapiens

Histidine decarboxylase
type: ProteinReference
xref: PTHR11999:SF68
xref: uniprot P16453 10
organism: Rattus norvegicus

Bos taurus
type: BioSource
xref: ncbitaxon 9913 19

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 3

uniprot Q7PWE0 20
type: UnificationXref
id: Q7PWE0
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Histidine-RIGHT__CO2-_Histamine-_re1
controller: pyridoxal phosphate (vitamin B6)

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Histidine-RIGHT__CO2-_Histamine-_re1
controller: Histidine decarboxylase

eco ECO:0000250 4
type: UnificationXref
id: ECO:0000250
db: eco

ncbitaxon 10116 11
type: UnificationXref
id: 10116
db: ncbitaxon

Mus musculus
type: BioSource
xref: ncbitaxon 10090 15

uniprot Q5EA83 18
type: UnificationXref
id: Q5EA83
db: uniprot

Histidine Decarboxylase
type: ProteinReference
xref: P04493
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Histidine Decarboxylase Synonym: Synonym not specified Accession: P04493
comment: ENTITY_REFERENCE_ID_DESC=Histamine synthesis.PROTEIN.GENERIC.Histidine Decarboxylase
member entity reference: Histidine decarboxylase
member entity reference: AGAP009001-PA (Fragment)
member entity reference: HDC isoform 1

ncbitaxon 9606 13
type: UnificationXref
id: 9606
db: ncbitaxon

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 13

CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Histidine decarboxylase
type: ProteinReference
xref: PTHR11999:SF68
xref: uniprot Q05733 16
organism: Drosophila melanogaster

uniprot E2RMU1 6
type: UnificationXref
id: E2RMU1
db: uniprot

PTHR11999:SF68
type: RelationshipXref
id: PTHR11999:SF68
db: PANTHER Family
relationship type: By Homology

Histamine synthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Histidine-RIGHT__CO2-_Histamine-_re1
xref: PANTHER Pathway P04387 1
comment: MODEL_NOTES=No pathway definition

HDC isoform 1
type: ProteinReference
xref: uniprot H2Q9E8 8
xref: PTHR11999:SF68
organism: Pan troglodytes

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 17

uniprot P23738 14
type: UnificationXref
id: P23738
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 4

By Homology
type: RelationshipTypeVocabulary

ncbitaxon 7165 21
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot P16453 10
type: UnificationXref
id: P16453
db: uniprot

ncbitaxon 7227 17
type: UnificationXref
id: 7227
db: ncbitaxon

ncbitaxon 9544 3
type: UnificationXref
id: 9544
db: ncbitaxon

Histidine decarboxylase
type: ProteinReference
xref: PTHR11999:SF68
xref: uniprot Q5EA83 18
organism: Bos taurus

Histidine decarboxylase
type: ProteinReference
xref: PTHR11999:SF68
xref: uniprot P23738 14
organism: Mus musculus

P04493
type: UnificationXref
id: P04493
db: PANTHER Pathway Component

ncbitaxon 9598 9
type: UnificationXref
id: 9598
db: ncbitaxon

Histidine decarboxylase
type: ProteinReference
xref: uniprot A0A1D5QCD6 2
xref: PTHR11999:SF68
organism: Macaca mulatta

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 11

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 7

uniprot Q05733 16
type: UnificationXref
id: Q05733
db: uniprot

uniprot H2Q9E8 8
type: UnificationXref
id: H2Q9E8
db: uniprot

Histidine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A1D5QCD6 2
type: UnificationXref
id: A0A1D5QCD6
db: uniprot