Histidinol-phosphate aminotransferase
type: ProteinReference
xref: uniprot P07172 82
organism: Saccharomyces cerevisiae

Histidinol-phosphate aminotransferase
type: ProteinReference
xref: uniprot P17731 84
organism: Bacillus subtilis

PARTICIPANT STOICHIOMETRY r4 144
type: Stoichiometry
physical entity: phosphoribulosoylformimino-AICAR phosphate
stoichiometric coefficient: 1.0

Histidinol dehydrogenase
type: ProteinReference
xref: uniprot Q9P777 44
organism: Schizosaccharomyces pombe

PARTICIPANT STOICHIOMETRY r4 143
type: Stoichiometry
physical entity: phosphoribosylformimino-AICAR-phosphate
stoichiometric coefficient: 1.0

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 103

STATE_TRANSITION_LEFT__D_erythro_imidazol_glycerol_phosphate-RIGHT__imidazol_acetol_phosphate-_H2O-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 174
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 173
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 175
left: D-erythro-imidazol glycerol phosphate
interaction type: STATE_TRANSITION
right: imidazol acetol phosphate
right: H2O

ATP phosphoribosyl transferase
type: ProteinReference
xref: P02987
comment: ENTITY_REFERENCE_ID_DESC=Histidine biosynthesis.PROTEIN.GENERIC.ATP phosphoribosyl_br_transferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: ATP phosphoribosyl transferase Synonym: Synonym not specified Accession: P02987
member entity reference: ATP phosphoribosyltransferase 1, chloroplastic
member entity reference: ATP phosphoribosyltransferase
member entity reference: ATP phosphoribosyltransferase 2, chloroplastic

uniprot Q8EXX8 54
type: UnificationXref
id: Q8EXX8
db: uniprot

uniprot O34912 47
type: UnificationXref
id: O34912
db: uniprot

uniprot Q9C5U8 43
type: UnificationXref
id: Q9C5U8
db: uniprot

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 18

uniprot P9WML5 88
type: UnificationXref
id: P9WML5
db: uniprot

Histidinol dehydrogenase
type: ProteinReference
xref: uniprot Q9RSI4 45
organism: Deinococcus radiodurans

uniprot O66976 32
type: UnificationXref
id: O66976
db: uniprot

Histidinol-phosphate transaminase
type: ProteinReference
xref: uniprot Q9HPL0 102
organism: Halobacterium salinarum

uniprot P9WML7 90
type: UnificationXref
id: P9WML7
db: uniprot

uniprot Q9ZBY8 111
type: UnificationXref
id: Q9ZBY8
db: uniprot

uniprot Q9RUE2 69
type: UnificationXref
id: Q9RUE2
db: uniprot

PARTICIPANT STOICHIOMETRY r2 151
type: Stoichiometry
physical entity: phosphoribosyl-AMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 150
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

Probable histidinol-phosphatase
type: ProteinReference
xref: uniprot O14059 72
organism: Schizosaccharomyces pombe

PARTICIPANT STOICHIOMETRY r6 173
type: Stoichiometry
physical entity: D-erythro-imidazol glycerol phosphate
stoichiometric coefficient: 1.0

ncbitaxon 3702 3
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot Q8A7Z4 128
type: UnificationXref
id: Q8A7Z4
db: uniprot

uniprot Q9X0D2 71
type: UnificationXref
id: Q9X0D2
db: uniprot

histidinol
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r6 175
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 174
type: Stoichiometry
physical entity: imidazol acetol phosphate
stoichiometric coefficient: 1.0

uniprot Q9RWD6 55
type: UnificationXref
id: Q9RWD6
db: uniprot

uniprot Q7SDF1 62
type: UnificationXref
id: Q7SDF1
db: uniprot

ncbitaxon 189518 24
type: UnificationXref
id: 189518
db: ncbitaxon

glutamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 83332 89
type: UnificationXref
id: 83332
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_histidinol_phosphate-RIGHT__PO4-_histidinol-_r8
controller: Histidinol-phosphatase

ncbitaxon 190304 97
type: UnificationXref
id: 190304
db: ncbitaxon

uniprot O34683 4
type: UnificationXref
id: O34683
db: uniprot

Imidazole glycerol phosphate synthase subunit HisF
type: ProteinReference
xref: uniprot Q8TT96 131
organism: Methanosarcina acetivorans

Histidine biosynthesis trifunctional protein
type: ProteinReference
xref: uniprot P07685 36
organism: Neurospora crassa

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_phosphoribosyl_AMP-RIGHT__phosphoribosylformimino_AICAR_phosphate-_r3
controller: Phosphoribosyl AMP cyclohydrolase

uniprot Q9X0C5 56
type: UnificationXref
id: Q9X0C5
db: uniprot

PARTICIPANT STOICHIOMETRY r1 153
type: Stoichiometry
physical entity: PRPP
stoichiometric coefficient: 1.0

Os02g0709200 protein
type: ProteinReference
xref: uniprot Q0DY86 92
organism: Oryza sativa

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 30

PARTICIPANT STOICHIOMETRY r1 154
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

uniprot Q58365 94
type: UnificationXref
id: Q58365
db: uniprot

PARTICIPANT STOICHIOMETRY r1 155
type: Stoichiometry
physical entity: phosphoribosyl-ATP
stoichiometric coefficient: 1.0

ATP phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q8CK28 65
organism: Streptomyces coelicolor

Histidinol-phosphate aminotransferase
type: ProteinReference
xref: uniprot Q9HQS0 104
organism: Halobacterium salinarum

uniprot Q8REW4 96
type: UnificationXref
id: Q8REW4
db: uniprot

ATP phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q7SDF1 62
organism: Neurospora crassa

Imidazole glycerol phosphate synthase subunit HisH
type: ProteinReference
xref: uniprot Q8TS91 130
organism: Methanosarcina acetivorans

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__imidazol_acetol_phosphate-_glutamate-RIGHT__2_ketoglutarate-_histidinol_phosphate-_r7
controller: Histidinephosphate aminotransferase

ATP phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q8F6P1 66
organism: Leptospira interrogans

PARTICIPANT STOICHIOMETRY r1 152
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Imidazole glycerol phosphate synthase subunit HisF
type: ProteinReference
xref: uniprot P59119 120
organism: Leptospira interrogans

uniprot P06988 34
type: UnificationXref
id: P06988
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 9

STATE_TRANSITION_LEFT__NAD-_histidinol-RIGHT__histidinal-_NADH-_r9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 164
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 162
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 161
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 163
left: NAD
left: histidinol
interaction type: STATE_TRANSITION
right: NADH
right: histidinal

Imidazole glycerol phosphate synthase subunit HisH
type: ProteinReference
xref: uniprot P59118 119
organism: Leptospira interrogans

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 87

ATP phosphoribosyl transferase
type: Protein
entity reference: ATP phosphoribosyl transferase
comment: SPECIES_TYPE=PROTEIN

Imidazoleglycerol-phosphate dehydratase
type: ProteinReference
xref: uniprot P58878 15
organism: Methanosarcina acetivorans

PO4
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Histidinol dehydrogenase
type: ProteinReference
xref: uniprot Q7UX39 39
organism: Rhodopirellula baltica

Imidazole glycerol phosphate synthase subunit HisH
type: ProteinReference
xref: uniprot Q8A7Z4 128
organism: Bacteroides thetaiotaomicron

Phosphoribosyl AMP cyclohydrolase
type: Protein
entity reference: Phosphoribosyl AMP cyclohydrolase
comment: SPECIES_TYPE=PROTEIN

uniprot O34565 112
type: UnificationXref
id: O34565
db: uniprot

Histidine biosynthesis bifunctional protein HisIE
type: ProteinReference
xref: uniprot Q8A7Z7 53
organism: Bacteroides thetaiotaomicron

Imidazole glycerol phosphate synthase subunit HisF
type: ProteinReference
xref: uniprot Q8A7Z6 129
organism: Bacteroides thetaiotaomicron

STATE_TRANSITION_LEFT__NAD-_histidinal-_H2O-RIGHT__NADH-_histidine-_r10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 157
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 156
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 160
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 158
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 159
left: NAD
left: H2O
left: histidinal
interaction type: STATE_TRANSITION
right: NADH
right: histidine

Imidazole glycerol phosphate synthase subunit HisF
type: ProteinReference
xref: uniprot Q9S2T7 134
organism: Streptomyces coelicolor

ncbitaxon 251221 18
type: UnificationXref
id: 251221
db: ncbitaxon

phosphoribulosoylformimino-AICAR phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P06633 8
type: UnificationXref
id: P06633
db: uniprot

uniprot B9DHD3 79
type: UnificationXref
id: B9DHD3
db: uniprot

uniprot O94303 116
type: UnificationXref
id: O94303
db: uniprot

uniprot Q7UNC2 19
type: UnificationXref
id: Q7UNC2
db: uniprot

histidinal
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q7NFZ1 61
type: UnificationXref
id: Q7NFZ1
db: uniprot

Imidazole glycerol phosphate synthase subunit HisH
type: ProteinReference
xref: uniprot Q9RX89 133
organism: Deinococcus radiodurans

uniprot Q9RRM7 109
type: UnificationXref
id: Q9RRM7
db: uniprot

PARTICIPANT STOICHIOMETRY r7 169
type: Stoichiometry
physical entity: imidazol acetol phosphate
stoichiometric coefficient: 1.0

uniprot O67857 80
type: UnificationXref
id: O67857
db: uniprot

PARTICIPANT STOICHIOMETRY r2 149
type: Stoichiometry
physical entity: phosphoribosyl-ATP
stoichiometric coefficient: 1.0

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 26

Imidazole glycerol phosphate synthase hisHF, chloroplastic
type: ProteinReference
xref: uniprot Q9SZ30 135
organism: Arabidopsis thaliana

uniprot Q9X0C8 137
type: UnificationXref
id: Q9X0C8
db: uniprot

Histidinol-phosphatase
type: ProteinReference
xref: uniprot P38635 74
organism: Saccharomyces cerevisiae

uniprot Q9S762 70
type: UnificationXref
id: Q9S762
db: uniprot

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 22

ncbitaxon 64091 103
type: UnificationXref
id: 64091
db: ncbitaxon

Imidazoleglycerol-phosphate dehydratase
type: ProteinReference
xref: uniprot Q9RX91 27
organism: Deinococcus radiodurans

PARTICIPANT STOICHIOMETRY r2 148
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PANTHER Pathway P02747 1
type: UnificationXref
id: P02747
db: PANTHER Pathway

ATP phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q7URL0 63
organism: Rhodopirellula baltica

Phosphoribosyl-ATP pyrophosphatase
type: ProteinReference
xref: uniprot Q7URL1 52
organism: Rhodopirellula baltica

uniprot O34651 31
type: UnificationXref
id: O34651
db: uniprot

Phosphoribosyl AMP cyclohydrolase
type: ProteinReference
xref: P02989
comment: ENTITY_REFERENCE_ID_DESC=Histidine biosynthesis.PROTEIN.GENERIC.Phosphoribosyl AMP_br_cyclohydrolase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphoribosyl AMP cyclohydrolase Synonym: Synonym not specified Accession: P02989
member entity reference: Histidine biosynthesis bifunctional protein his7
member entity reference: Phosphoribosyl-ATP pyrophosphatase
member entity reference: Histidine biosynthesis bifunctional protein HisIE

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 14

uniprot Q7URL1 52
type: UnificationXref
id: Q7URL1
db: uniprot

uniprot Q8TT96 131
type: UnificationXref
id: Q8TT96
db: uniprot

glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8A7Z7 53
type: UnificationXref
id: Q8A7Z7
db: uniprot

Imidazoleglycerol-phosphate dehydratase
type: ProteinReference
xref: uniprot O34683 4
organism: Bacillus subtilis

uniprot Q9HEG3 25
type: UnificationXref
id: Q9HEG3
db: uniprot

Histidinol-phosphatase
type: ProteinReference
xref: P02990
comment: ENTITY_REFERENCE_ID_DESC=Histidine biosynthesis.PROTEIN.GENERIC.Histidinol-phosphatase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Histidinol-phosphatase Synonym: Synonym not specified Accession: P02990
member entity reference: Probable histidinol-phosphatase
member entity reference: Histidinol-phosphatase

uniprot Q8GSJ1 67
type: UnificationXref
id: Q8GSJ1
db: uniprot

Histidine biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__phosphoribosylformimino_AICAR_phosphate-RIGHT__phosphoribulosoylformimino_AICAR_phosphate-_r4
pathway component: STATE_TRANSITION_LEFT__D_erythro_imidazol_glycerol_phosphate-RIGHT__imidazol_acetol_phosphate-_H2O-_r6
pathway component: STATE_TRANSITION_LEFT__NAD-_histidinol-RIGHT__histidinal-_NADH-_r9
pathway component: STATE_TRANSITION_LEFT__ATP-_PRPP-RIGHT__PPi-_phosphoribosyl_ATP-_r1
pathway component: STATE_TRANSITION_LEFT__phosphoribulosoylformimino_AICAR_phosphate-_glutamine-RIGHT__glutamate-_D_erythro_imidazol_glycerol_phosphate-_AICAR-_r5
pathway component: STATE_TRANSITION_LEFT__H2O-_phosphoribosyl_AMP-RIGHT__phosphoribosylformimino_AICAR_phosphate-_r3
pathway component: STATE_TRANSITION_LEFT__H2O-_histidinol_phosphate-RIGHT__PO4-_histidinol-_r8
pathway component: STATE_TRANSITION_LEFT__NAD-_histidinal-_H2O-RIGHT__NADH-_histidine-_r10
pathway component: STATE_TRANSITION_LEFT__H2O-_phosphoribosyl_ATP-RIGHT__PPi-_phosphoribosyl_AMP-_r2
pathway component: STATE_TRANSITION_LEFT__imidazol_acetol_phosphate-_glutamate-RIGHT__2_ketoglutarate-_histidinol_phosphate-_r7
xref: PANTHER Pathway P02747 1
comment: MODEL_NOTES=The biosynthesis of the aromatic amino acid histidine critical for protein biosynthesis. Website=www.biocyc.org/Ecoli/Pathways/ free text=Biochemistry (text) Voet and Voet

ncbitaxon 224308 5
type: UnificationXref
id: 224308
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__D_erythro_imidazol_glycerol_phosphate-RIGHT__imidazol_acetol_phosphate-_H2O-_r6
controller: Imidazol glycerol phosphate dehydratase

uniprot Q8ABA9 40
type: UnificationXref
id: Q8ABA9
db: uniprot

Histidinol-phosphate aminotransferase
type: ProteinReference
xref: uniprot Q58365 94
organism: Methanocaldococcus jannaschii

Aminotransferase
type: ProteinReference
xref: uniprot Q93RW7 101
organism: Streptomyces coelicolor

uniprot Q9SZ30 135
type: UnificationXref
id: Q9SZ30
db: uniprot

Histidinol dehydrogenase
type: ProteinReference
xref: P02985
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Histidinol dehydrogenase Synonym: Synonym not specified Accession: P02985
comment: ENTITY_REFERENCE_ID_DESC=Histidine biosynthesis.PROTEIN.GENERIC.Histidinol dehydrogenase
member entity reference: Histidinol dehydrogenase
member entity reference: Histidinol dehydrogenase, chloroplastic
member entity reference: Histidine biosynthesis trifunctional protein

uniprot Q8ABA7 21
type: UnificationXref
id: Q8ABA7
db: uniprot

uniprot Q7NL02 38
type: UnificationXref
id: Q7NL02
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phosphoribulosoylformimino_AICAR_phosphate-_glutamine-RIGHT__glutamate-_D_erythro_imidazol_glycerol_phosphate-_AICAR-_r5
controller: Imidazol glycerol phosphate synthase

uniprot Q8F393 41
type: UnificationXref
id: Q8F393
db: uniprot

histidine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

histidinol-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Imidazole glycerol phosphate synthase hisHF
type: ProteinReference
xref: uniprot P33734 118
organism: Saccharomyces cerevisiae

Histidinol-phosphatase
type: ProteinReference
xref: uniprot O34411 73
organism: Bacillus subtilis

uniprot P16246 83
type: UnificationXref
id: P16246
db: uniprot

Imidazole glycerol phosphate synthase subunit HisF
type: ProteinReference
xref: uniprot P60664 122
organism: Escherichia coli

uniprot P17731 84
type: UnificationXref
id: P17731
db: uniprot

Histidinol-phosphatase
type: ProteinReference
xref: uniprot Q7SAH5 75
organism: Neurospora crassa

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 24

STATE_TRANSITION_LEFT__H2O-_histidinol_phosphate-RIGHT__PO4-_histidinol-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 168
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 166
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 167
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 165
left: histidinol-phosphate
left: H2O
interaction type: STATE_TRANSITION
right: PO4
right: histidinol

STATE_TRANSITION_LEFT__ATP-_PRPP-RIGHT__PPi-_phosphoribosyl_ATP-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 152
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 154
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 155
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 153
left: PRPP
left: ATP
interaction type: STATE_TRANSITION
right: phosphoribosyl-ATP
right: PPi

Imidazole glycerol phosphate synthase subunit HisH
type: ProteinReference
xref: uniprot Q7ULP3 127
organism: Rhodopirellula baltica

Probable aminotransferase
type: ProteinReference
xref: uniprot Q9I0V2 108
organism: Pseudomonas aeruginosa

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 28

Imidazoleglycerol-phosphate dehydratase
type: ProteinReference
xref: uniprot Q7NMJ6 17
organism: Gloeobacter violaceus

PARTICIPANT STOICHIOMETRY r5 139
type: Stoichiometry
physical entity: glutamine
stoichiometric coefficient: 1.0

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 95

Imidazoleglycerol-phosphate dehydratase
type: ProteinReference
xref: uniprot Q9HEG3 25
organism: Neurospora crassa

uniprot P07172 82
type: UnificationXref
id: P07172
db: uniprot

Imidazoleglycerol-phosphate dehydratase
type: ProteinReference
xref: uniprot O66455 6
organism: Aquifex aeolicus

PARTICIPANT STOICHIOMETRY r5 138
type: Stoichiometry
physical entity: phosphoribulosoylformimino-AICAR phosphate
stoichiometric coefficient: 1.0

Imidazole glycerol phosphate synthase hisHF
type: ProteinReference
xref: uniprot Q1K5X9 123
organism: Neurospora crassa

uniprot Q8TL41 42
type: UnificationXref
id: Q8TL41
db: uniprot

ATP phosphoribosyltransferase
type: ProteinReference
xref: uniprot P00498 59
organism: Saccharomyces cerevisiae

Imidazole glycerol phosphate synthase subunit HisH
type: ProteinReference
xref: uniprot O34565 112
organism: Bacillus subtilis

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 3

Phosphoribosyl ATP pyrophosphatase
type: Protein
entity reference: Phosphoribosyl ATP pyrophosphatase
comment: SPECIES_TYPE=PROTEIN

Histidinol dehydrogenase
type: ProteinReference
xref: uniprot Q8F393 41
organism: Leptospira interrogans

Histidinol-phosphatase
type: ProteinReference
xref: uniprot Q89ZW4 76
organism: Bacteroides thetaiotaomicron

PARTICIPANT STOICHIOMETRY r10 160
type: Stoichiometry
physical entity: histidine
stoichiometric coefficient: 1.0

uniprot P07685 36
type: UnificationXref
id: P07685
db: uniprot

Histidine biosynthesis bifunctional protein his7
type: ProteinReference
xref: uniprot O59667 48
organism: Schizosaccharomyces pombe

uniprot O34727 113
type: UnificationXref
id: O34727
db: uniprot

AICAR
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Imidazoleglycerol-phosphate dehydratase 1, chloroplastic
type: ProteinReference
xref: uniprot P34047 12
organism: Arabidopsis thaliana

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 89

ncbitaxon 226186 22
type: UnificationXref
id: 226186
db: ncbitaxon

ncbitaxon 178306 100
type: UnificationXref
id: 178306
db: ncbitaxon

Imidazoleglycerol-phosphate dehydratase
type: ProteinReference
xref: uniprot Q8F9R6 23
organism: Leptospira interrogans

uniprot Q7URL0 63
type: UnificationXref
id: Q7URL0
db: uniprot

uniprot O66455 6
type: UnificationXref
id: O66455
db: uniprot

Imidazole glycerol phosphate synthase hisHF
type: ProteinReference
xref: uniprot O94303 116
organism: Schizosaccharomyces pombe

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 35

PARTICIPANT STOICHIOMETRY r10 159
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 157
type: Stoichiometry
physical entity: histidinal
stoichiometric coefficient: 1.0

ncbitaxon 224324 7
type: UnificationXref
id: 224324
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r10 158
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

ncbitaxon 243232 95
type: UnificationXref
id: 243232
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r10 156
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

PPi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 284812 14
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot Q8F6P1 66
type: UnificationXref
id: Q8F6P1
db: uniprot

STATE_TRANSITION_LEFT__phosphoribulosoylformimino_AICAR_phosphate-_glutamine-RIGHT__glutamate-_D_erythro_imidazol_glycerol_phosphate-_AICAR-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 141
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 140
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 138
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 139
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 142
left: phosphoribulosoylformimino-AICAR phosphate
left: glutamine
interaction type: STATE_TRANSITION
right: AICAR
right: D-erythro-imidazol glycerol phosphate
right: glutamate

uniprot Q9HPL0 102
type: UnificationXref
id: Q9HPL0
db: uniprot

PARTICIPANT STOICHIOMETRY r5 142
type: Stoichiometry
physical entity: AICAR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 141
type: Stoichiometry
physical entity: D-erythro-imidazol glycerol phosphate
stoichiometric coefficient: 1.0

uniprot Q1K5X9 123
type: UnificationXref
id: Q1K5X9
db: uniprot

imidazol acetol phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r5 140
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

uniprot O34411 73
type: UnificationXref
id: O34411
db: uniprot

STATE_TRANSITION_LEFT__imidazol_acetol_phosphate-_glutamate-RIGHT__2_ketoglutarate-_histidinol_phosphate-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 170
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 172
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 171
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 169
left: imidazol acetol phosphate
left: glutamate
interaction type: STATE_TRANSITION
right: histidinol-phosphate
right: 2-ketoglutarate

PRPP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__phosphoribosylformimino_AICAR_phosphate-RIGHT__phosphoribulosoylformimino_AICAR_phosphate-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 143
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 144
left: phosphoribosylformimino-AICAR-phosphate
interaction type: STATE_TRANSITION
right: phosphoribulosoylformimino-AICAR phosphate

Histidinol-phosphate aminotransferase
type: ProteinReference
xref: uniprot Q9RRM7 109
organism: Deinococcus radiodurans

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_phosphoribosyl_ATP-RIGHT__PPi-_phosphoribosyl_AMP-_r2
controller: Phosphoribosyl ATP pyrophosphatase

Phosphoribosyl ATP pyrophosphatase
type: ProteinReference
xref: P02986
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Histidine biosynthesis.PROTEIN.GENERIC.Phosphoribosyl ATP_br_pyrophosphatase
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphoribosyl ATP pyrophosphatase Synonym: Synonym not specified Accession: P02986
member entity reference: Histidine biosynthesis bifunctional protein his7
member entity reference: Phosphoribosyl-ATP pyrophosphatase
member entity reference: Histidine biosynthesis bifunctional protein HisIE

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Imidazole glycerol phosphate synthase subunit HisH
type: ProteinReference
xref: uniprot O66943 115
organism: Aquifex aeolicus

uniprot P60595 121
type: UnificationXref
id: P60595
db: uniprot

phosphoribosyl-AMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q93RW7 101
type: UnificationXref
id: Q93RW7
db: uniprot

Histidinol dehydrogenase
type: ProteinReference
xref: uniprot O34651 31
organism: Bacillus subtilis

NAD
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Histidinal dehydrogenase
type: Protein
entity reference: Histidinal dehydrogenase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 559292 9
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot Q9RX91 27
type: UnificationXref
id: Q9RX91
db: uniprot

uniprot Q0DY86 92
type: UnificationXref
id: Q0DY86
db: uniprot

P02992
type: UnificationXref
id: P02992
db: PANTHER Pathway Component

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 5

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 97

P02990
type: UnificationXref
id: P02990
db: PANTHER Pathway Component

P02991
type: UnificationXref
id: P02991
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phosphoribosylformimino_AICAR_phosphate-RIGHT__phosphoribulosoylformimino_AICAR_phosphate-_r4
controller: Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase

Imidazole glycerol phosphate synthase subunit HisH
type: ProteinReference
xref: uniprot P60595 121
organism: Escherichia coli

uniprot Q8A7P6 77
type: UnificationXref
id: Q8A7P6
db: uniprot

uniprot Q9RX45 78
type: UnificationXref
id: Q9RX45
db: uniprot

Imidazol glycerol phosphate synthase
type: ProteinReference
xref: P02992
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Histidine biosynthesis.PROTEIN.GENERIC.Imidazol glycerol_br_phosphate synthase
comment: ENTITY_REFERENCE_NOTES=Long Name: Imidazol glycerol phosphate synthase Synonym: Synonym not specified Accession: P02992
member entity reference: Imidazole glycerol phosphate synthase subunit HisH
member entity reference: Imidazole glycerol phosphate synthase subunit HisF
member entity reference: Imidazole glycerol phosphate synthase hisHF
member entity reference: Imidazole glycerol phosphate synthase hisHF, chloroplastic

ATP phosphoribosyltransferase
type: ProteinReference
xref: uniprot P40373 60
organism: Schizosaccharomyces pombe

Imidazoleglycerol-phosphate dehydratase
type: ProteinReference
xref: uniprot P40374 13
organism: Schizosaccharomyces pombe

P02989
type: UnificationXref
id: P02989
db: PANTHER Pathway Component

P02988
type: UnificationXref
id: P02988
db: PANTHER Pathway Component

P02987
type: UnificationXref
id: P02987
db: PANTHER Pathway Component

uniprot Q7ULP3 127
type: UnificationXref
id: Q7ULP3
db: uniprot

P02986
type: UnificationXref
id: P02986
db: PANTHER Pathway Component

uniprot P16249 117
type: UnificationXref
id: P16249
db: uniprot

ncbitaxon 367110 26
type: UnificationXref
id: 367110
db: ncbitaxon

P02985
type: UnificationXref
id: P02985
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r9 161
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Uncharacterized aminotransferase Rv2231c
type: ProteinReference
xref: uniprot P9WQ89 91
organism: Mycobacterium tuberculosis

PARTICIPANT STOICHIOMETRY r9 162
type: Stoichiometry
physical entity: histidinol
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 163
type: Stoichiometry
physical entity: histidinal
stoichiometric coefficient: 1.0

P02984
type: UnificationXref
id: P02984
db: PANTHER Pathway Component

uniprot P73807 86
type: UnificationXref
id: P73807
db: uniprot

Histidine biosynthesis bifunctional protein HisIE
type: ProteinReference
xref: uniprot Q9X0C5 56
organism: Thermotoga maritima

Imidazole glycerol phosphate synthase subunit HisH
type: ProteinReference
xref: uniprot Q9X0C8 137
organism: Thermotoga maritima

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 16

Imidazoleglycerol-phosphate dehydratase
type: ProteinReference
xref: uniprot Q9X0C9 29
organism: Thermotoga maritima

Imidazole glycerol phosphate synthase subunit HisF
type: ProteinReference
xref: uniprot Q9X0C6 136
organism: Thermotoga maritima

ncbitaxon 100226 11
type: UnificationXref
id: 100226
db: ncbitaxon

STATE_TRANSITION_LEFT__H2O-_phosphoribosyl_ATP-RIGHT__PPi-_phosphoribosyl_AMP-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 150
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 151
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 149
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 148
left: H2O
left: phosphoribosyl-ATP
interaction type: STATE_TRANSITION
right: PPi
right: phosphoribosyl-AMP

Imidazol glycerol phosphate dehydratase
type: ProteinReference
xref: P02984
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Histidine biosynthesis.PROTEIN.GENERIC.Imidazol glycerol_br_phosphate dehydratase
comment: ENTITY_REFERENCE_NOTES=Long Name: Imidazol glycerol phosphate dehydratase Synonym: Synonym not specified Accession: P02984
member entity reference: Imidazoleglycerol-phosphate dehydratase
member entity reference: Imidazoleglycerol-phosphate dehydratase 1, chloroplastic
member entity reference: Histidine biosynthesis bifunctional protein HisB
member entity reference: Imidazoleglycerol-phosphate dehydratase 2, chloroplastic

uniprot P40373 60
type: UnificationXref
id: P40373
db: uniprot

Histidinol-phosphate aminotransferase 1, chloroplastic
type: ProteinReference
xref: uniprot B9DHD3 79
organism: Arabidopsis thaliana

Histidinephosphate aminotransferase
type: ProteinReference
xref: P02991
standard name: Histidinol phosphate aminotransferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Histidine biosynthesis.PROTEIN.GENERIC.Histidinephosphate_br_aminotransferase
comment: ENTITY_REFERENCE_NOTES=Long Name: Histidinol phosphate aminotransferase Synonym: Synonym not specified Accession: P02991
member entity reference: Histidinol-phosphate aminotransferase (HisC)
member entity reference: Histidinol-phosphate aminotransferase
member entity reference: Histidinol-phosphate aminotransferase 1
member entity reference: Histidinol-phosphate transaminase
member entity reference: Os02g0709200 protein
member entity reference: Probable aminotransferase
member entity reference: Histidinol-phosphate aminotransferase 1, chloroplastic
member entity reference: Histidinol-phosphate aminotransferase 2
member entity reference: Putative phenylalanine aminotransferase
member entity reference: Aminotransferase
member entity reference: Uncharacterized aminotransferase Rv2231c

uniprot Q9P777 44
type: UnificationXref
id: Q9P777
db: uniprot

Imidazole glycerol phosphate synthase subunit HisF
type: ProteinReference
xref: uniprot O34727 113
organism: Bacillus subtilis

PARTICIPANT STOICHIOMETRY r9 164
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

ATP phosphoribosyltransferase
type: ProteinReference
xref: uniprot O67543 58
organism: Aquifex aeolicus

uniprot Q9S2T7 134
type: UnificationXref
id: Q9S2T7
db: uniprot

uniprot P06986 81
type: UnificationXref
id: P06986
db: uniprot

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 7

uniprot Q8CK28 65
type: UnificationXref
id: Q8CK28
db: uniprot

Imidazole glycerol phosphate synthase subunit HisF
type: ProteinReference
xref: uniprot O66567 114
organism: Aquifex aeolicus

uniprot Q8F9R6 23
type: UnificationXref
id: Q8F9R6
db: uniprot

Histidinal dehydrogenase
type: ProteinReference
xref: P02988
comment: ENTITY_REFERENCE_NOTES=Long Name: Histidinal dehydrogenase Synonym: Synonym not specified Accession: P02988
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Histidine biosynthesis.PROTEIN.GENERIC.Histidinal dehydrogenase
member entity reference: Histidinol dehydrogenase
member entity reference: Histidinol dehydrogenase, chloroplastic
member entity reference: Histidine biosynthesis trifunctional protein

uniprot P16245 37
type: UnificationXref
id: P16245
db: uniprot

Histidinol-phosphate aminotransferase
type: ProteinReference
xref: uniprot Q9X0D0 110
organism: Thermotoga maritima

uniprot P00498 59
type: UnificationXref
id: P00498
db: uniprot

Histidinol dehydrogenase
type: ProteinReference
xref: uniprot Q9X0D1 46
organism: Thermotoga maritima

uniprot Q9I0V2 108
type: UnificationXref
id: Q9I0V2
db: uniprot

ATP phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9X0D2 71
organism: Thermotoga maritima

Phosphoribosylformimino-5-amino-1-phosphoribosyl-4 imadazol carboxamide isomerase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot P36605 85
type: UnificationXref
id: P36605
db: uniprot

Imidazoleglycerol-phosphate dehydratase
type: ProteinReference
xref: uniprot P06633 8
organism: Saccharomyces cerevisiae

uniprot O67543 58
type: UnificationXref
id: O67543
db: uniprot

PARTICIPANT STOICHIOMETRY r8 168
type: Stoichiometry
physical entity: histidinol
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 167
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

ncbitaxon 39947 93
type: UnificationXref
id: 39947
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r8 166
type: Stoichiometry
physical entity: histidinol-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 165
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

ATP phosphoribosyltransferase 2, chloroplastic
type: ProteinReference
xref: uniprot Q8GSJ1 67
organism: Arabidopsis thaliana

uniprot O34520 57
type: UnificationXref
id: O34520
db: uniprot

Histidinol-phosphate aminotransferase 1
type: ProteinReference
xref: uniprot Q9HVX0 105
organism: Pseudomonas aeruginosa

Histidinol dehydrogenase
type: ProteinReference
xref: uniprot Q8TL41 42
organism: Methanosarcina acetivorans

ATP phosphoribosyltransferase
type: ProteinReference
xref: uniprot O34520 57
organism: Bacillus subtilis

uniprot O23346 2
type: UnificationXref
id: O23346
db: uniprot

Histidinol-phosphate aminotransferase (HisC)
type: ProteinReference
xref: uniprot Q8ZY38 99
organism: Pyrobaculum aerophilum

Imidazol glycerol phosphate synthase
type: Protein
entity reference: Imidazol glycerol phosphate synthase
comment: SPECIES_TYPE=PROTEIN

uniprot P06989 50
type: UnificationXref
id: P06989
db: uniprot

Histidinol-phosphate aminotransferase 2
type: ProteinReference
xref: uniprot Q9HZ68 107
organism: Pseudomonas aeruginosa

phosphoribosylformimino-AICAR-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 100

Imidazoleglycerol-phosphate dehydratase
type: ProteinReference
xref: uniprot Q7UNC2 19
organism: Rhodopirellula baltica

PARTICIPANT STOICHIOMETRY r7 170
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

Putative phenylalanine aminotransferase
type: ProteinReference
xref: uniprot Q9ZBY8 111
organism: Streptomyces coelicolor

uniprot Q8TUE9 98
type: UnificationXref
id: Q8TUE9
db: uniprot

PARTICIPANT STOICHIOMETRY r7 172
type: Stoichiometry
physical entity: histidinol-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 171
type: Stoichiometry
physical entity: 2-ketoglutarate
stoichiometric coefficient: 1.0

uniprot O59667 48
type: UnificationXref
id: O59667
db: uniprot

uniprot P33734 118
type: UnificationXref
id: P33734
db: uniprot

uniprot O66943 115
type: UnificationXref
id: O66943
db: uniprot

uniprot Q7SAH5 75
type: UnificationXref
id: Q7SAH5
db: uniprot

uniprot Q9X0D0 110
type: UnificationXref
id: Q9X0D0
db: uniprot

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 20

phosphoribosyl-ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 11

uniprot P16247 10
type: UnificationXref
id: P16247
db: uniprot

uniprot Q9RSI4 45
type: UnificationXref
id: Q9RSI4
db: uniprot

uniprot Q89ZW4 76
type: UnificationXref
id: Q89ZW4
db: uniprot

uniprot Q8TU56 68
type: UnificationXref
id: Q8TU56
db: uniprot

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r3 145
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Histidine biosynthesis bifunctional protein HisB
type: ProteinReference
xref: uniprot Q8ABA7 21
organism: Bacteroides thetaiotaomicron

D-erythro-imidazol glycerol phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r3 146
type: Stoichiometry
physical entity: phosphoribosyl-AMP
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PRPP-RIGHT__PPi-_phosphoribosyl_ATP-_r1
controller: ATP phosphoribosyl transferase

PARTICIPANT STOICHIOMETRY r3 147
type: Stoichiometry
physical entity: phosphoribosylformimino-AICAR-phosphate
stoichiometric coefficient: 1.0

Histidinephosphate aminotransferase
type: Protein
entity reference: Histidinephosphate aminotransferase
comment: SPECIES_TYPE=PROTEIN

uniprot P38635 74
type: UnificationXref
id: P38635
db: uniprot

uniprot O14059 72
type: UnificationXref
id: O14059
db: uniprot

Histidinol dehydrogenase
type: Protein
entity reference: Histidinol dehydrogenase
comment: SPECIES_TYPE=PROTEIN

uniprot Q7NLB5 51
type: UnificationXref
id: Q7NLB5
db: uniprot

uniprot Q7UKJ9 126
type: UnificationXref
id: Q7UKJ9
db: uniprot

ncbitaxon 243230 28
type: UnificationXref
id: 243230
db: ncbitaxon

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

Histidinol-phosphate aminotransferase
type: ProteinReference
xref: uniprot Q8TUE9 98
organism: Methanosarcina acetivorans

Phosphoribosyl-ATP pyrophosphatase
type: ProteinReference
xref: uniprot Q8EXX8 54
organism: Leptospira interrogans

Imidazoleglycerol-phosphate dehydratase 2, chloroplastic
type: ProteinReference
xref: uniprot O23346 2
organism: Arabidopsis thaliana

Histidinol-phosphatase
type: ProteinReference
xref: uniprot Q8A7P6 77
organism: Bacteroides thetaiotaomicron

Histidinol dehydrogenase
type: ProteinReference
xref: uniprot Q8ABA9 40
organism: Bacteroides thetaiotaomicron

Histidine biosynthesis bifunctional protein HisIE
type: ProteinReference
xref: uniprot O34912 47
organism: Bacillus subtilis

ATP phosphoribosyltransferase 1, chloroplastic
type: ProteinReference
xref: uniprot Q9S762 70
organism: Arabidopsis thaliana

Imidazole glycerol phosphate synthase subunit HisF
type: ProteinReference
xref: uniprot Q7NDC1 124
organism: Gloeobacter violaceus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NAD-_histidinal-_H2O-RIGHT__NADH-_histidine-_r10
controller: Histidinal dehydrogenase

ncbitaxon 243274 30
type: UnificationXref
id: 243274
db: ncbitaxon

Imidazole glycerol phosphate synthase subunit HisF
type: ProteinReference
xref: uniprot Q9RWD7 132
organism: Deinococcus radiodurans

uniprot Q9HQS0 104
type: UnificationXref
id: Q9HQS0
db: uniprot

ATP phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q8ABB0 64
organism: Bacteroides thetaiotaomicron

ATP phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9RUE2 69
organism: Deinococcus radiodurans

uniprot P34047 12
type: UnificationXref
id: P34047
db: uniprot

Histidine biosynthesis bifunctional protein HisIE
type: ProteinReference
xref: uniprot Q9RWD6 55
organism: Deinococcus radiodurans

NADH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Imidazole glycerol phosphate synthase subunit HisH
type: ProteinReference
xref: uniprot Q7NNK4 125
organism: Gloeobacter violaceus

Histidinol-phosphatase
type: Protein
entity reference: Histidinol-phosphatase
comment: SPECIES_TYPE=PROTEIN

uniprot Q7UX39 39
type: UnificationXref
id: Q7UX39
db: uniprot

Histidinol dehydrogenase
type: ProteinReference
xref: uniprot P16245 37
organism: Streptomyces coelicolor

ncbitaxon 83333 35
type: UnificationXref
id: 83333
db: ncbitaxon

uniprot Q7NNK4 125
type: UnificationXref
id: Q7NNK4
db: uniprot

ncbitaxon 243090 20
type: UnificationXref
id: 243090
db: ncbitaxon

uniprot Q9RWD7 132
type: UnificationXref
id: Q9RWD7
db: uniprot

Imidazol glycerol phosphate dehydratase
type: Protein
entity reference: Imidazol glycerol phosphate dehydratase
comment: SPECIES_TYPE=PROTEIN

uniprot Q7NMJ6 17
type: UnificationXref
id: Q7NMJ6
db: uniprot

Histidine biosynthesis bifunctional protein HisIE
type: ProteinReference
xref: uniprot Q7NLB5 51
organism: Gloeobacter violaceus

Imidazole glycerol phosphate synthase subunit HisH
type: ProteinReference
xref: uniprot P16249 117
organism: Streptomyces coelicolor

uniprot P58878 15
type: UnificationXref
id: P58878
db: uniprot

Histidinol-phosphate aminotransferase
type: ProteinReference
xref: uniprot P16246 83
organism: Streptomyces coelicolor

ncbitaxon 208964 106
type: UnificationXref
id: 208964
db: ncbitaxon

Histidinol dehydrogenase
type: ProteinReference
xref: uniprot O66976 32
organism: Aquifex aeolicus

Imidazoleglycerol-phosphate dehydratase
type: ProteinReference
xref: uniprot P16247 10
organism: Streptomyces coelicolor

Histidinol-phosphate aminotransferase
type: ProteinReference
xref: uniprot Q8REW4 96
organism: Fusobacterium nucleatum

uniprot P40374 13
type: UnificationXref
id: P40374
db: uniprot

uniprot P9WQ89 91
type: UnificationXref
id: P9WQ89
db: uniprot

uniprot Q9HVX0 105
type: UnificationXref
id: Q9HVX0
db: uniprot

Putative phenylalanine aminotransferase
type: ProteinReference
xref: uniprot P9WML5 88
organism: Mycobacterium tuberculosis

ATP phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q8TU56 68
organism: Methanosarcina acetivorans

Histidinol-phosphate aminotransferase
type: ProteinReference
xref: uniprot P9WML7 90
organism: Mycobacterium tuberculosis

Imidazole glycerol phosphate synthase subunit HisF
type: ProteinReference
xref: uniprot Q7UKJ9 126
organism: Rhodopirellula baltica

uniprot P59119 120
type: UnificationXref
id: P59119
db: uniprot

Histidine biosynthesis bifunctional protein HisIE
type: ProteinReference
xref: uniprot O67780 49
organism: Aquifex aeolicus

uniprot Q7NDC1 124
type: UnificationXref
id: Q7NDC1
db: uniprot

uniprot P59118 119
type: UnificationXref
id: P59118
db: uniprot

uniprot Q9X0D1 46
type: UnificationXref
id: Q9X0D1
db: uniprot

Histidinol dehydrogenase
type: ProteinReference
xref: uniprot P06988 34
organism: Escherichia coli

Histidine biosynthesis bifunctional protein HisIE
type: ProteinReference
xref: uniprot P06989 50
organism: Escherichia coli

Histidinol dehydrogenase
type: ProteinReference
xref: uniprot Q7NL02 38
organism: Gloeobacter violaceus

uniprot Q9X0C6 136
type: UnificationXref
id: Q9X0C6
db: uniprot

uniprot Q8TS91 130
type: UnificationXref
id: Q8TS91
db: uniprot

Histidinol-phosphate aminotransferase
type: ProteinReference
xref: uniprot P06986 81
organism: Escherichia coli

uniprot O66567 114
type: UnificationXref
id: O66567
db: uniprot

Histidinol-phosphate aminotransferase
type: ProteinReference
xref: uniprot P36605 85
organism: Schizosaccharomyces pombe

uniprot Q8ABB0 64
type: UnificationXref
id: Q8ABB0
db: uniprot

2-ketoglutarate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ATP phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q7NFZ1 61
organism: Gloeobacter violaceus

uniprot P60664 122
type: UnificationXref
id: P60664
db: uniprot

uniprot Q9RX89 133
type: UnificationXref
id: Q9RX89
db: uniprot

uniprot O67780 49
type: UnificationXref
id: O67780
db: uniprot

ncbitaxon 1111708 87
type: UnificationXref
id: 1111708
db: ncbitaxon

uniprot Q9X0C9 29
type: UnificationXref
id: Q9X0C9
db: uniprot

STATE_TRANSITION_LEFT__H2O-_phosphoribosyl_AMP-RIGHT__phosphoribosylformimino_AICAR_phosphate-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 146
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 145
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 147
left: H2O
left: phosphoribosyl-AMP
interaction type: STATE_TRANSITION
right: phosphoribosylformimino-AICAR-phosphate

uniprot Q9HZ68 107
type: UnificationXref
id: Q9HZ68
db: uniprot

uniprot P00815 33
type: UnificationXref
id: P00815
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NAD-_histidinol-RIGHT__histidinal-_NADH-_r9
controller: Histidinol dehydrogenase

Histidinol-phosphate aminotransferase
type: ProteinReference
xref: uniprot O67857 80
organism: Aquifex aeolicus

uniprot Q8ZY38 99
type: UnificationXref
id: Q8ZY38
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 93

Histidinol-phosphate aminotransferase
type: ProteinReference
xref: uniprot P73807 86
organism: Synechocystis

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 106

Histidinol dehydrogenase, chloroplastic
type: ProteinReference
xref: uniprot Q9C5U8 43
organism: Arabidopsis thaliana

Histidine biosynthesis trifunctional protein
type: ProteinReference
xref: uniprot P00815 33
organism: Saccharomyces cerevisiae

Probable histidinol-phosphatase
type: ProteinReference
xref: uniprot Q9RX45 78
organism: Deinococcus radiodurans

uniprot Q8A7Z6 129
type: UnificationXref
id: Q8A7Z6
db: uniprot

ncbitaxon 188937 16
type: UnificationXref
id: 188937
db: ncbitaxon