Glyceraldehyde-3-phosphate dehydrogenase
Actin-related protein 2/3 complex subunit 5
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.N-Wasp
Glutamate ionotropic receptor NMDA type subunit 2A
Paired amphipathic helix protein Sin3-like 2
Dynein, cytoplasmic 1, intermediate chain 2
Glyceraldehyde-3-phosphate dehydrogenase 2
Non-specific serine/threonine protein kinase
ENTITY_REFERENCE_NOTES= Long Name: Calpain Synonym: Synonym not specified Accession: P00788
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Calpain
SH3 domain containing GRB2 like 3, endophilin A3
Actin-related protein 2/3 complex subunit 1
Probable proline dehydrogenase, mitochondrial
Synaptic vesicle membrane protein VAT-1 homolog
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.PSD-95
Ras-related C3 botulinum toxin substrate 1
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.N-CoR
Protein kinase C and casein kinase substrate in neurons protein 1
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Dynactin
Glyceraldehyde-3-phosphate dehydrogenase GAPCP1, chloroplastic
Cytoplasmic dynein 1 light intermediate chain 1
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.TRUNCATED.Truncated_br_Htt
ENTITY_REFERENCE_NOTES= Long Name: Truncated Htt Synonym: Synonym not specified Accession: P00761
Chromosome 1, whole genome shotgun sequence
Glutamate ionotropic receptor NMDA type subunit 3A
Dual specificity mitogen-activated protein kinase kinase 7
Tumor necrosis factor alpha-induced protein 8
SIN3 transcription regulator family member A
Actin-related protein 2/3 complex subunit
Dynein cytoplasmic 1 light intermediate chain 1
Glutamate receptor ionotropic, kainate 4
CD42_CHICK Cell division control protein 42 homolog (G25K GTP-binding protein)MODA
BCL2-associated X, apoptosis regulator a
Actin-related protein 2/3 complex subunit 1A
Glutamate receptor, ionotropic, N-methyl D-aspartate 1a
Glyceraldehyde-3-phosphate dehydrogenase 1
RAC-alpha serine/threonine-protein kinase
RAC-beta serine/threonine-protein kinase
Glutamate ionotropic receptor kainate type subunit 3
Cytoplasmic FMR1-interacting protein 1 homolog
Complex (NMDA receptor/PSD-95/ Kainate receptor/Htt/ HAP1/Duo)
ENTITY_REFERENCE_NOTES= Long Name: Polyglutamine expanded mutant huntingtin Synonym: Synonym not specified Accession: G01532
ENTITY_REFERENCE_ID_DESC=Huntington disease.GENE.GENE.PolyQ HTT
Polyglutamine expanded mutant huntingtin
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Caspase 6
ENTITY_REFERENCE_NOTES= Long Name: Caspase 6 Synonym: Synonym not specified Accession: P00809
Mitogen activated protein kinase kinase 4
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.MAPKK4
ENTITY_REFERENCE_NOTES= Long Name: Mitogen activated protein kinase kinase 4 Synonym: MEK4,MKK4 Accession: P00787
Glutamate receptor, ionotropic, kainate 5
ENTITY_REFERENCE_NOTES= Long Name: P53 tumor suppressor phosphoprotein Synonym: TP53 Accession: P00797
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.p53
Protein kinase C and casein kinase substrate in neurons 1
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.PACSIN-1
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Synaptojanin
Cytochrome c1, heme protein, mitochondrial
Putative cytochrome c1, heme protein,mitochondrial
Paired amphipathic helix protein Sin3-like 4
Dynein cytoplasmic 1 light intermediate chain 2
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.ION_CHANNEL.NMDA_br_receptor
ENTITY_REFERENCE_NOTES= Long Name: N-methyl-d-aspartate receptor Synonym: Synonym not specified Accession: P00778
MODEL_NOTES=Panther Pathway: P00029 Huntington's disease is associated with a mutant polyglutamine expansion in the huntingtin gene. Wild-type huntingtin protein is normally involved in vesicle endocytosis, regulation of calcium channels via the PSD-95 complex, and inhibition of apoptosis via BDNF. Mutant, polyglutamine expanded huntingtin may lose these functions, as well as gain toxicity via stimulation of apoptosis, regulation of gene transcription via p53, and abnormal calcium-mediated signal transduction pathways. Medline=11724916 Medline=12569151 Medline=12932731 Medline=14526190 PMID: 11724916 PMID: 12569151 PMID: 12932731 PMID: 14526190
N-methyl D-aspartate receptor subtype 2B
Glutamate receptor ionotropic, kainate 1
Cytoplasmic dynein 1 light intermediate chain 2
SIN3 transcription regulator family member B
Actin-related protein 2/3 complex subunit 5-like protein
Src homology region 3-containing Grb2-like protein 3
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.SH3GL3
Mitogen-activated protein kinase kinase 4A
Huntingtin-interacting protein 1-related
Complex (Htt/SH3GL3/ PACSIN-1/Synaptojanin/ N-Wasp)
Cell division control protein 42 homolog
Actin-related protein 2/3 complex subunit 1B
Ras-related C3 botulinum toxin substrate 2
Brain-derived neurotrophic factor (Fragment)
Glutamate receptor ionotropic, kainate 5
Dual specificity mitogen-activated protein kinase kinase 4
Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic
Glutamate receptor ionotropic, kainate 2
Glutamate receptor ionotropic, kainate 3
Mitogen-activated protein kinase kinase kinase 10
ENTITY_REFERENCE_NOTES= Long Name: Proline oxidase Synonym: Synonym not specified Accession: G01529
ENTITY_REFERENCE_ID_DESC=Huntington disease.GENE.GENE.Proline_br_oxidase
Dynein, cytoplasmic 1, light intermediate chain 1
ADP-ribosylation factor, putative, expressed
Huntingtin-interacting protein 1-related protein
Fos proto-oncogene, AP-1 transcription factor subunit
Glutamate ionotropic receptor kainate type subunit 1
RAC-gamma serine/threonine-protein kinase
Glutamate receptor, ionotropic, kainate 1
Cytoplasmic dynein 1 intermediate chain 2
Dynein cytoplasmic 1 intermediate chain 2
ENTITY_REFERENCE_NOTES= Long Name: alpha-Adaptin Synonym: Synonym not specified Accession: P00782
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC._alpha_-Adaptin
Glutamate ionotropic receptor NMDA type subunit 1
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Dynein_br_complex
Caspase 8, apoptosis-related cysteine peptidase
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.TBP
FBJ murine osteosarcoma viral oncogene homolog
ENTITY_REFERENCE_NOTES= Long Name: Stress signalling kinase 1 Synonym: Synonym not specified Accession: P00792
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.SEK-1
ENTITY_REFERENCE_NOTES= Long Name: c-Jun N-terminal kinase 2 Synonym: Synonym not specified Accession: P00799
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.JNK-2
Intraflagellar transport protein 57 homolog
Synaptic vesicle membrane protein VAT-1 homolog-like
Caspase 3, apoptosis-related cysteine peptidase a
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Sp1
Cytoplasmic dynein 1 intermediate chain 1
Mitogen-activated protein kinase kinase 4
Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic
ENTITY_REFERENCE_ID_DESC=Huntington disease.GENE.GENE.BDNF
ENTITY_REFERENCE_NOTES= Long Name: Brain-derived neurotrophic factor Synonym: Synonym not specified Accession: G01531
ENTITY_REFERENCE_NOTES= Long Name: c-Jun Synonym: Synonym not specified Accession: P00776
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.c-Jun
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.TAFII130
Transcription initiation factor TFIID subunit 4
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Fos protein
ENTITY_REFERENCE_NOTES= Long Name: Fos protein Synonym: c-fos Accession: P00801
Disease-associated mutant huntingtin containing polyglutamine expansion
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.PolyQ Htt
ENTITY_REFERENCE_NOTES= Long Name: Disease-associated mutant huntingtin containing polyglutamine expansion Synonym: Synonym not specified Accession: P00800
Histone deacetylase complex subunit Sin3a
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Sin3A
Cell division control protein 42 homolog isoform 2
ADP-ribosylation factor-interacting protein 2
Adaptor related protein complex 2 subunit alpha 2
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.MLK-2
ENTITY_REFERENCE_NOTES= Long Name: Mixed lineage kinase 2 Synonym: MAPKKK10 Accession: P00764
Ras-related C3 botulinum toxin substrate
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Rac
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.ARF
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Rab8
ENTITY_REFERENCE_NOTES= Long Name: Pro-caspase 8 Synonym: Synonym not specified Accession: P00767
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Pro-caspase 8
Dual specificity mitogen-activated protein kinase kinase sek-1
Glutamate ionotropic receptor kainate type subunit 2
Vesicle amine transport protein 1 homolog (T. californica)-like
Glyceraldehyde-3-phosphate dehydrogenase 4
Glyceraldehyde-3-phosphate dehydrogenase 3
ENTITY_REFERENCE_NOTES= Long Name: Hip1 protein interactor Synonym: Synonym not specified Accession: P00794
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Hippi
Mitogen-activated protein kinase kinase 7
Cytochrome c1 1, heme protein, mitochondrial
Complex (Hip-12/Hip-1/ Clathrin/alpha-Adaptin/ Htt/Actin)
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Akt
ENTITY_REFERENCE_NOTES= Long Name: Thymoma Viral Proto-Oncogene 1 Synonym: PKB,PKB/Akt,Pkb alpha Accession: P00805
Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html
ENTITY_REFERENCE_NOTES= Long Name: Caspase 3 Synonym: Synonym not specified Accession: P00812
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Caspase 3
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Clathrin
ENTITY_REFERENCE_NOTES= Long Name: Clathrin Synonym: Synonym not specified Accession: P00798
Website http://harvester.embl.de/harvester/Q149/Q14957.htm
Website http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm
Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html
Website http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436
Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html
ADP ribosylation factor-like 4, isoform B
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Arp2/3 complex
ENTITY_REFERENCE_NOTES= Long Name: Actin-related protein 2 and 3 complex Synonym: Synonym not specified Accession: P00811
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.ION_CHANNEL.Kainate_br_receptor
ENTITY_REFERENCE_NOTES= Long Name: Kainate receptor Synonym: Synonym not specified Accession: P00796
Glutamate [NMDA] receptor subunit zeta-1 isoform NR1-3
ENTITY_REFERENCE_NOTES= Long Name: Huntington interacting protein-1 Synonym: Synonym not specified Accession: P00765
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Hip-1
TAF (TBP-associated transcription factor) family
ENTITY_REFERENCE_NOTES= Long Name: Bcl-2-associated X protein Synonym: Synonym not specified Accession: G01533
ENTITY_REFERENCE_ID_DESC=Huntington disease.GENE.GENE.Bax
ENTITY_REFERENCE_NOTES= Long Name: Caspase 8 Synonym: Synonym not specified Accession: P00808
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.TRUNCATED.Caspase 8
Glyceraldehyde-3-phosphate dehydrogenase A
Glyceraldehyde-3-phosphate dehydrogenase (Fragment)
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.CBP
ENTITY_REFERENCE_NOTES= Long Name: CREB binding protein Synonym: Synonym not specified Accession: P00777
Novel protein similar to vertebrate ADP-ribosylation factor 4 (ARF4) (Zgc:77650)
Cytochrome c1 2, heme protein, mitochondrial
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.FIP-2
Glutamate receptor, ionotropic, kainate 1b
Dynein light intermediate chain, isoform A
ENTITY_REFERENCE_NOTES= Long Name: Huntingtin Synonym: Synonym not specified Accession: G01530
ENTITY_REFERENCE_ID_DESC=Huntington disease.GENE.GENE.HTT
GroES-like zinc-binding alcohol dehydrogenase family protein
Mitogen-activated protein kinase kinase kinase
Ras homolog gene family, member G (Rho G)
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Htt
ENTITY_REFERENCE_NOTES= Long Name: Huntingtin Synonym: Synonym not specified Accession: P00766
ENTITY_REFERENCE_NOTES= Long Name: Apoptotic protease activating factor-1 Synonym: Synonym not specified Accession: P00768
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Apaf-1
Glyceraldehyde-3-phosphate dehydrogenase GAPA2, chloroplastic
ENTITY_REFERENCE_NOTES= Long Name: beta-Tubulin Synonym: Synonym not specified Accession: P00790
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC._beta_-Tubulin
ENTITY_REFERENCE_NOTES= Long Name: Cytochrome c Synonym: Synonym not specified Accession: P00785
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Cytochrome c
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.BDNF
ENTITY_REFERENCE_NOTES= Long Name: Brain-derived neurotrophic factor Synonym: Synonym not specified Accession: P00795
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Arfaptin-2
ENTITY_REFERENCE_NOTES= Long Name: Tumor protein p53 inducible protein 3 Synonym: Synonym not specified Accession: G01535
ENTITY_REFERENCE_ID_DESC=Huntington disease.GENE.GENE.PIG3
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.HAP1
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Actin
ENTITY_REFERENCE_NOTES= Long Name: Actin Synonym: F-actin Accession: P00807
Mitogen activated protein kinase kinase 7
ENTITY_REFERENCE_NOTES= Long Name: Mitogen activated protein kinase kinase 7 Synonym: MKK7 Accession: P00784
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.MAPKK7
Huntingtin-associated protein interacting protein
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Duo
ENTITY_REFERENCE_NOTES= Long Name: Huntingtin-associated protein interacting protein Synonym: Kalirin Accession: P00773
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Microtubule
N-methyl-D-aspartate receptor type 1 subunit
Glutamate receptor, ionotropic, N-methyl D-aspartate 1b
Complex (Microtubule/Dynein complex/ Dynactin/HAP1/ Htt)
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.GAPDH
ENTITY_REFERENCE_NOTES= Long Name: Glyceraldehyde-3-phosphate dehydrogenase Synonym: G3PD Accession: P00810
Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic
ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Hip-12
Glyceraldehyde-3-phosphate dehydrogenase GAPCP2, chloroplastic
Glutamate ionotropic receptor kainate type subunit 5
Glyceraldehyde-3-phosphate dehydrogenase 3, cytosolic
Cytoplasmic FMR1-interacting protein homolog
ADP ribosylation factor interacting protein 2
Glyceraldehyde-3-phosphate dehydrogenase GAPB, chloroplastic
Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic
Jun proto-oncogene, AP-1 transcription factor subunit
Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic