Htt
type: Protein
entity reference: Htt
feature: COMPLEX PARTICIPANT BINDING FEATURE s63 sa20 1649
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ABF7 1422
xref: PTHR11711:SF119
organism: Monodelphis domestica

uniprot P20227 1337
type: UnificationXref
id: P20227
db: uniprot

AP-2 complex subunit alpha
type: ProteinReference
xref: uniprot F7C503 883
xref: PTHR22780:SF33
organism: Monodelphis domestica

uniprot F7E905 1007
type: UnificationXref
id: F7E905
db: uniprot

uniprot P0CE13 941
type: UnificationXref
id: P0CE13
db: uniprot

uniprot F7DQK7 288
type: UnificationXref
id: F7DQK7
db: uniprot

Rac family small GTPase 3
type: ProteinReference
xref: PTHR24072:SF301
xref: uniprot F6THF0 1228
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r18 1666
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

uniprot Q9BPX5 1061
type: UnificationXref
id: Q9BPX5
db: uniprot

PARTICIPANT STOICHIOMETRY r18 1665
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

Caspase-6
type: ProteinReference
xref: uniprot O35397 1118
xref: PTHR10454:SF206
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR10676:SF314
xref: uniprot F6VUB3 483
organism: Macaca mulatta

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q8IKK7 983
organism: Plasmodium falciparum

uniprot Q13509 817
type: UnificationXref
id: Q13509
db: uniprot

uniprot A8WS32 212
type: UnificationXref
id: A8WS32
db: uniprot

PTHR11588:SF395
type: RelationshipXref
id: PTHR11588:SF395
db: PANTHER Family
relationship type: By Homology

uniprot B0JZE7 1390
type: UnificationXref
id: B0JZE7
db: uniprot

PTHR24351:SF200
type: RelationshipXref
id: PTHR24351:SF200
db: PANTHER Family
relationship type: By Homology

c Jun s115 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

Histone acetyltransferase HAC4
type: ProteinReference
xref: uniprot Q9LG11 1019
xref: PTHR13808:SF30
organism: Arabidopsis thaliana

uniprot Q38AR9 967
type: UnificationXref
id: Q38AR9
db: uniprot

uniprot H3E6Q9 1437
type: UnificationXref
id: H3E6Q9
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot P0CN74 943
organism: Cryptococcus neoformans

uniprot P56559 1459
type: UnificationXref
id: P56559
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 15

uniprot Q6TYR6 847
type: UnificationXref
id: Q6TYR6
db: uniprot

uniprot F1PY87 1004
type: UnificationXref
id: F1PY87
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q7ZWH4 1059
xref: PTHR12644:SF1
organism: Danio rerio

uniprot A0A1D5QE40 21
type: UnificationXref
id: A0A1D5QE40
db: uniprot

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot F6UXY7 481
organism: Ornithorhynchus anatinus

uniprot F1PB20 124
type: UnificationXref
id: F1PB20
db: uniprot

uniprot A0A0G2K3H5 86
type: UnificationXref
id: A0A0G2K3H5
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot E2RU88 916
organism: Giardia intestinalis

uniprot F6XLU1 685
type: UnificationXref
id: F6XLU1
db: uniprot

uniprot P07437 789
type: UnificationXref
id: P07437
db: uniprot

uniprot E2RDH6 461
type: UnificationXref
id: E2RDH6
db: uniprot

PARTICIPANT STOICHIOMETRY r80 1664
type: Stoichiometry
physical entity: Complex (Htt/Hip-1)
stoichiometric coefficient: 1.0

uniprot F7GA51 691
type: UnificationXref
id: F7GA51
db: uniprot

N-Wasp
type: ProteinReference
xref: P00769
standard name: neural Wiskott-Aldrich syndrome protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.N-Wasp
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Uncharacterized protein
member entity reference: Neural Wiskott-Aldrich syndrome protein
member entity reference: WASL isoform 1
member entity reference: Wiskott-Aldrich syndrome like

PARTICIPANT STOICHIOMETRY r80 1662
type: Stoichiometry
physical entity: Hip-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r80 1663
type: Stoichiometry
physical entity: Htt
stoichiometric coefficient: 1.0

uniprot Q2QN41 1346
type: UnificationXref
id: Q2QN41
db: uniprot

uniprot Q9R1S8 175
type: UnificationXref
id: Q9R1S8
db: uniprot

PTHR11588:SF376
type: RelationshipXref
id: PTHR11588:SF376
db: PANTHER Family
relationship type: By Homology

PTHR11588:SF375
type: RelationshipXref
id: PTHR11588:SF375
db: PANTHER Family
relationship type: By Homology

uniprot Q90828 572
type: UnificationXref
id: Q90828
db: uniprot

Actin related protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A8BV70 208
organism: Giardia intestinalis

uniprot Q9WUA6 1174
type: UnificationXref
id: Q9WUA6
db: uniprot

PTHR24072:SF301
type: RelationshipXref
id: PTHR24072:SF301
db: PANTHER Family
relationship type: By Homology

uniprot Q95107 1073
type: UnificationXref
id: Q95107
db: uniprot

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF37
xref: uniprot F6ZPQ4 282
organism: Monodelphis domestica

Cytoplasmatic actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot E9FXV8 259
organism: Daphnia pulex

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF37
xref: uniprot A7MB62 201
organism: Bos taurus

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot G3X6J7 692
organism: Bos taurus

Glutamate ionotropic receptor NMDA type subunit 2A
type: ProteinReference
evidence: Evidence 23
evidence: Evidence 25
evidence: Evidence 22
evidence: Evidence 24
xref: uniprot F1PXS6 37
xref: PTHR18966:SF407
organism: Canis lupus familiaris

uniprot P05220 788
type: UnificationXref
id: P05220
db: uniprot

uniprot Q7TMM9 856
type: UnificationXref
id: Q7TMM9
db: uniprot

ncbitaxon 13616 39
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot G2HGK8 773
type: UnificationXref
id: G2HGK8
db: uniprot

Paired amphipathic helix protein Sin3a
type: ProteinReference
xref: uniprot Q96ST3 106
xref: PTHR12346:SF2
organism: Homo sapiens

Dynein heavy chain, cytoplasmic
type: ProteinReference
xref: PTHR10676:SF314
xref: uniprot P37276 522
organism: Drosophila melanogaster

AGAP010435-PA (Fragment)
type: ProteinReference
xref: PTHR10676:SF374
xref: uniprot Q5TUD8 545
organism: Anopheles gambiae

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 361

PTHR11588:SF389
type: RelationshipXref
id: PTHR11588:SF389
db: PANTHER Family
relationship type: By Homology

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF73
xref: uniprot E2RL64 466
organism: Canis lupus familiaris

uniprot P09244 792
type: UnificationXref
id: P09244
db: uniprot

uniprot Q8LPL6 897
type: UnificationXref
id: Q8LPL6
db: uniprot

Paired amphipathic helix protein Sin3-like 2
type: ProteinReference
xref: PTHR12346:SF8
xref: uniprot Q9LFQ3 107
organism: Arabidopsis thaliana

ncbitaxon 321614 294
type: UnificationXref
id: 321614
db: ncbitaxon

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot P17871 1335
organism: Schizosaccharomyces pombe

uniprot F7B0D4 94
type: UnificationXref
id: F7B0D4
db: uniprot

uniprot A7EN31 1378
type: UnificationXref
id: A7EN31
db: uniprot

uniprot Q7JY07 978
type: UnificationXref
id: Q7JY07
db: uniprot

uniprot Q01714 1125
type: UnificationXref
id: Q01714
db: uniprot

uniprot P63170 528
type: UnificationXref
id: P63170
db: uniprot

uniprot E1B9R5 458
type: UnificationXref
id: E1B9R5
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF389
xref: uniprot Q6XNL8 395
organism: Danio rerio

Tubulin beta-4B chain
type: ProteinReference
xref: PTHR11588:SF247
xref: uniprot P68372 811
organism: Mus musculus

Tubulin beta-4B chain
type: ProteinReference
xref: PTHR11588:SF247
xref: uniprot P68371 810
organism: Homo sapiens

uniprot F6QE96 1161
type: UnificationXref
id: F6QE96
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot Q6P367 842
xref: PTHR11588:SF314
organism: Xenopus tropicalis

AP-2 complex subunit alpha
type: ProteinReference
xref: uniprot A0A2I3RV17 878
xref: PTHR22780:SF33
organism: Pan troglodytes

ADP-ribosylation factor 6a
type: ProteinReference
xref: uniprot Q6P2U5 1505
xref: PTHR11711:SF322
organism: Danio rerio

uniprot A2EM29 901
type: UnificationXref
id: A2EM29
db: uniprot

uniprot Q6PBH4 551
type: UnificationXref
id: Q6PBH4
db: uniprot

Tubulin beta-4 chain
type: ProteinReference
xref: PTHR11588:SF329
xref: uniprot P24636 799
organism: Arabidopsis thaliana

Uncharacterized protein
type: ProteinReference
xref: PTHR12442:SF34
xref: uniprot E1C7N2 460
organism: Gallus gallus

Dynein, cytoplasmic 1, intermediate chain 2
type: ProteinReference
xref: PTHR12442:SF37
xref: uniprot F7BCN5 493
organism: Xenopus tropicalis

uniprot O96860 519
type: UnificationXref
id: O96860
db: uniprot

ncbitaxon 10116 20
type: UnificationXref
id: 10116
db: ncbitaxon

Fos protein s114 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fos protein
stoichiometric coefficient: 1.0

ADP ribosylation factor 5
type: ProteinReference
xref: PTHR11711:SF323
xref: uniprot A4IFP7 1377
organism: Bos taurus

Glutamate receptor ionotropic, NMDA 3B
type: ProteinReference
evidence: Evidence 49
evidence: Evidence 81
xref: PTHR18966:SF364
xref: uniprot Q8VHN2 82
organism: Rattus norvegicus

uniprot W4XTP5 415
type: UnificationXref
id: W4XTP5
db: uniprot

Dynein heavy chain, cytoplasmic
type: ProteinReference
xref: PTHR10676:SF314
xref: uniprot Q19020 533
organism: Caenorhabditis elegans

uniprot H2R986 509
type: UnificationXref
id: H2R986
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase 2
type: ProteinReference
xref: uniprot O43026 927
organism: Schizosaccharomyces pombe

Actin, cytoplasmic 2
type: ProteinReference
xref: uniprot Q6P378 391
xref: PTHR11937:SF192
organism: Xenopus tropicalis

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot P0CE13 941
organism: Chlamydia trachomatis

uniprot F7ABF7 1422
type: UnificationXref
id: F7ABF7
db: uniprot

Actin-7
type: ProteinReference
xref: PTHR11937:SF408
xref: uniprot P0C540 309
organism: Oryza sativa

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot D3ZGY4 914
xref: PTHR10836:SF111
organism: Rattus norvegicus

uniprot E1B8D6 1002
type: UnificationXref
id: E1B8D6
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot E7EXT6 1157
organism: Danio rerio

uniprot F6SY88 1415
type: UnificationXref
id: F6SY88
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Cytochrome_c-RIGHT__Cytochrome_c-_r29

uniprot B8JK21 1146
type: UnificationXref
id: B8JK21
db: uniprot

uniprot A9TBY6 1387
type: UnificationXref
id: A9TBY6
db: uniprot

HTT
type: RnaRegion
cellular location: synapse
comment: SPECIES_TYPE=RNA

uniprot C3XYC3 236
type: UnificationXref
id: C3XYC3
db: uniprot

Brain-derived neurotrophic factor
type: DnaReference
xref: PTHR11589:SF3
organism: Homo sapiens

uniprot Q90YM8 710
type: UnificationXref
id: Q90YM8
db: uniprot

…
type: Stoichiometry
physical entity: Actin
stoichiometric coefficient: 8.0

uniprot Q92178 168
type: UnificationXref
id: Q92178
db: uniprot

uniprot P24636 799
type: UnificationXref
id: P24636
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6QP11 1162
organism: Monodelphis domestica

Putative dynein heavy chain, cytosolic
type: ProteinReference
xref: uniprot Q4QBN6 542
xref: PTHR10676:SF314
organism: Leishmania major

uniprot D3ZJZ8 118
type: UnificationXref
id: D3ZJZ8
db: uniprot

uniprot P84079 1476
type: UnificationXref
id: P84079
db: uniprot

Glutamate receptor ionotropic, NMDA3A
type: ProteinReference
evidence: Evidence 27
evidence: Evidence 22
xref: PTHR18966:SF397
xref: uniprot A2AIR5 26
organism: Mus musculus

AP-2 complex subunit alpha-1
type: ProteinReference
xref: uniprot O95782 886
xref: PTHR22780:SF33
organism: Homo sapiens

Calpain 7
type: ProteinReference
xref: uniprot E2R0F7 121
xref: PTHR46143:SF1
organism: Canis lupus familiaris

uniprot F1PFN3 919
type: UnificationXref
id: F1PFN3
db: uniprot

Rho-related protein racC
type: ProteinReference
xref: uniprot P34149 1251
organism: Dictyostelium discoideum

Rho-related protein racA
type: ProteinReference
xref: uniprot P34147 1249
organism: Dictyostelium discoideum

Rho-related protein racB
type: ProteinReference
xref: uniprot P34148 1250
organism: Dictyostelium discoideum

Rho-related protein rac1B
type: ProteinReference
xref: uniprot P34145 1247
organism: Dictyostelium discoideum

Rho-related protein rac1C
type: ProteinReference
xref: uniprot P34146 1248
organism: Dictyostelium discoideum

Nuclear receptor corepressor 2
type: ProteinReference
xref: PTHR13992:SF21
xref: uniprot Q9Y618 1373
organism: Homo sapiens

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P79734 703
xref: PTHR11447:SF6
organism: Danio rerio

uniprot A0A0R4IXC8 716
type: UnificationXref
id: A0A0R4IXC8
db: uniprot

Rho-related protein rac1A
type: ProteinReference
xref: uniprot P34144 1246
organism: Dictyostelium discoideum

ncbitaxon 7227 72
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot P00359 931
type: UnificationXref
id: P00359
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot F7HPP3 643
organism: Macaca mulatta

Apoptosis
type: Pathway

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s99 sa48 1655
cellular location: synapse
comment: SPECIES_TYPE=ION

Calpain
type: ProteinReference
xref: P00788
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Calpain Synonym: Synonym not specified Accession: P00788
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Calpain
member entity reference: Calpain-12
member entity reference: Calpain-5
member entity reference: Calpain-6
member entity reference: Calpain 6
member entity reference: Calpain-10
member entity reference: Calpain-1 catalytic subunit
member entity reference: Calpain-3
member entity reference: Calpain-2 catalytic subunit
member entity reference: Uncharacterized protein
member entity reference: CAPN3 isoform 4
member entity reference: Calpain small subunit 1
member entity reference: Calpain-9
member entity reference: Calpain-11
member entity reference: Calpain-8
member entity reference: CAPN10 isoform 1
member entity reference: Calpain 5
member entity reference: CAPN7 isoform 3
member entity reference: CAPNS1 isoform 6
member entity reference: CaLPain family
member entity reference: Calpain-7
member entity reference: Zgc:55262
member entity reference: Calpain small subunit 2
member entity reference: CAPN9 isoform 1
member entity reference: Calpain 1
member entity reference: Calpain 2
member entity reference: Calpain 7
member entity reference: AGAP010834-PA
member entity reference: Calpain-A
member entity reference: Calpain-10 isoform a
member entity reference: Calpain 3
member entity reference: Protein CBR-TRA-3
member entity reference: Calpain 12

Tubulin beta chain
type: ProteinReference
xref: uniprot H2QS82 776
xref: PTHR11588:SF247
organism: Pan troglodytes

c-Jun
type: Protein
entity reference: c-Jun
feature: c Jun s28 a41 rs1
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot E3KPL3 748
organism: Puccinia graminis

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF43
xref: uniprot A0A1D5PEI5 717
organism: Gallus gallus

uniprot B3RJW0 453
type: UnificationXref
id: B3RJW0
db: uniprot

uniprot F1MG21 631
type: UnificationXref
id: F1MG21
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JNK_2-RIGHT__JNK_2-_r17
controller: SEK-1

Tubulin beta chain
type: ProteinReference
xref: uniprot F6SYL0 759
organism: Ciona intestinalis

MODULATION
type: RelationshipTypeVocabulary

clathrin coat of endocytic vesicle
type: CellularLocationVocabulary
xref: GO GO:0030128 2

c-Jun
type: Protein
entity reference: c-Jun
feature: c Jun s29 a42 rs1
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot E7F5R2 630
type: UnificationXref
id: E7F5R2
db: uniprot

uniprot Q5U1Y2 1281
type: UnificationXref
id: Q5U1Y2
db: uniprot

00696
type: UnificationXref
id: MOD:00696
db: mod

uniprot Q4QEJ1 1494
type: UnificationXref
id: Q4QEJ1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_r39
controller: PolyQ Htt

SIN3 homolog A, transcription regulator
type: ProteinReference
xref: uniprot H2R491 99
xref: PTHR12346:SF2
organism: Pan troglodytes

HAP1 s110 sa53 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: HAP1
stoichiometric coefficient: 1.0

uniprot P90623 364
type: UnificationXref
id: P90623
db: uniprot

uniprot E3JPY7 1401
type: UnificationXref
id: E3JPY7
db: uniprot

uniprot O61707 181
type: UnificationXref
id: O61707
db: uniprot

ADP-ribosylation factor 2
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot P19146 1447
organism: Saccharomyces cerevisiae

ADP-ribosylation factor-like protein 1
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot Q2YDM1 1488
organism: Bos taurus

Putative actin-9
type: ProteinReference
xref: PTHR11937:SF483
xref: uniprot P93738 365
organism: Arabidopsis thaliana

Physcomitrella patens
type: BioSource
xref: ncbitaxon 3218 219

SH3 domain containing GRB2 like 3, endophilin A3
type: ProteinReference
xref: uniprot H2QA01 1180
xref: PTHR14167:SF45
organism: Pan troglodytes

uniprot H2Q6P9 1430
type: UnificationXref
id: H2Q6P9
db: uniprot

uniprot A2AIR5 26
type: UnificationXref
id: A2AIR5
db: uniprot

uniprot Q6P7Z6 1508
type: UnificationXref
id: Q6P7Z6
db: uniprot

uniprot F1PQQ7 1368
type: UnificationXref
id: F1PQQ7
db: uniprot

AGAP000723-PA
type: ProteinReference
xref: uniprot Q7QEC0 561
xref: PTHR12688:SF0
organism: Anopheles gambiae

Dynein light chain 2, cytoplasmic
type: ProteinReference
xref: uniprot O96860 519
xref: PTHR11886:SF89
organism: Drosophila melanogaster

Complex (Htt/PolyQ Htt)
type: Complex
component stoichiometry: Htt s3 sa1 STOICHIOMETRY ID COMPLEX
component: Htt
component: PolyQ Htt
feature: COMPLEX BINDING FEATURE s6 a9 1582
feature: COMPLEX BINDING FEATURE s6 a9 1580
cellular location: synapse

uniprot Q6P5M9 843
type: UnificationXref
id: Q6P5M9
db: uniprot

Probable cytochrome c1
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q9HVY6 1204
organism: Pseudomonas aeruginosa

Uncharacterized protein
type: ProteinReference
xref: uniprot H3EPN0 1438
xref: PTHR11711:SF375
organism: Pristionchus pacificus

uniprot A9RY37 734
type: UnificationXref
id: A9RY37
db: uniprot

uniprot H2Q913 693
type: UnificationXref
id: H2Q913
db: uniprot

uniprot Q67VP4 1282
type: UnificationXref
id: Q67VP4
db: uniprot

uniprot P07384 150
type: UnificationXref
id: P07384
db: uniprot

uniprot C3XYC7 240
type: UnificationXref
id: C3XYC7
db: uniprot

uniprot C3YJC1 1215
type: UnificationXref
id: C3YJC1
db: uniprot

Rho family GTPase
type: ProteinReference
xref: uniprot C4M8K6 1220
organism: Entamoeba histolytica

Brain-derived neurotrophic factor
type: ProteinReference
xref: uniprot P23560 597
xref: PTHR11589:SF3
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QS62 605
xref: PTHR24055:SF172
organism: Pan troglodytes

Tumor protein 63 (p63)
type: ProteinReference
xref: uniprot F7DUR2 689
xref: PTHR11447:SF8
organism: Ornithorhynchus anatinus

Actin-related protein 2/3 complex subunit 1
type: ProteinReference
xref: uniprot P38328 1049
xref: PTHR10709:SF2
organism: Saccharomyces cerevisiae

uniprot F1MD32 1003
type: UnificationXref
id: F1MD32
db: uniprot

Probable quinone oxidoreductase
type: DnaReference
xref: PTHR48106:SF13
organism: Schizosaccharomyces pombe

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q8F5H7 981
organism: Leptospira interrogans

uniprot F6URI0 1417
type: UnificationXref
id: F6URI0
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot O67161 928
organism: Aquifex aeolicus

uniprot Q6DIV8 388
type: UnificationXref
id: Q6DIV8
db: uniprot

Probable proline dehydrogenase, mitochondrial
type: DnaReference
organism: Schizosaccharomyces pombe

Dynactin, 150 kDa isoform
type: ProteinReference
xref: uniprot Q01397 1318
xref: PTHR18916:SF70
organism: Neurospora crassa

uniprot Q64467 975
type: UnificationXref
id: Q64467
db: uniprot

Synaptic vesicle membrane protein VAT-1 homolog
type: DnaReference
xref: PTHR44054:SF1
organism: Rattus norvegicus

uniprot A8Y5B7 451
type: UnificationXref
id: A8Y5B7
db: uniprot

uniprot Q9HN56 1362
type: UnificationXref
id: Q9HN56
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot A2EM81 723
xref: PTHR11588:SF9
organism: Trichomonas vaginalis

AP-2 complex subunit alpha
type: ProteinReference
xref: uniprot A0A1D5NV94 876
xref: PTHR22780:SF30
organism: Gallus gallus

PTHR18966:SF38
type: RelationshipXref
id: PTHR18966:SF38
db: PANTHER Family
relationship type: By Homology

Retrograde transport
type: Pathway

PTHR18966:SF36
type: RelationshipXref
id: PTHR18966:SF36
db: PANTHER Family
relationship type: By Homology

ncbitaxon 224324 929
type: UnificationXref
id: 224324
db: ncbitaxon

G01529
type: UnificationXref
id: G01529
db: PANTHER Pathway Component

Calpain-1 catalytic subunit
type: ProteinReference
xref: uniprot O35350 143
xref: PTHR10183:SF284
organism: Mus musculus

Dynein axonemal heavy chain 7
type: ProteinReference
xref: PTHR10676:SF310
xref: uniprot H2QJ64 504
organism: Pan troglodytes

G01533
type: UnificationXref
id: G01533
db: PANTHER Pathway Component

G01532
type: UnificationXref
id: G01532
db: PANTHER Pathway Component

FIP-2
type: Protein
entity reference: FIP-2
feature: COMPLEX PARTICIPANT BINDING FEATURE s90 sa43 1635
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

G01535
type: UnificationXref
id: G01535
db: PANTHER Pathway Component

PSD-95
type: ProteinReference
xref: P00789
standard name: Postsynaptic density 95
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.PSD-95
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Disks large homolog 4
member entity reference: Discs large MAGUK scaffold protein 4
member entity reference: Uncharacterized protein
member entity reference: DLG4 isoform 1

uniprot F6R9F4 273
type: UnificationXref
id: F6R9F4
db: uniprot

uniprot Q9CPW4 1062
type: UnificationXref
id: Q9CPW4
db: uniprot

Dynein heavy chain 5, axonemal
type: ProteinReference
xref: PTHR10676:SF344
xref: uniprot Q8VHE6 569
organism: Mus musculus

G01531
type: UnificationXref
id: G01531
db: PANTHER Pathway Component

uniprot P84085 1482
type: UnificationXref
id: P84085
db: uniprot

G01530
type: UnificationXref
id: G01530
db: PANTHER Pathway Component

ADP-ribosylation factor, putative
type: ProteinReference
xref: uniprot Q38D64 1490
xref: PTHR11711:SF30
organism: Trypanosoma brucei

ADP-ribosylation factor, putative
type: ProteinReference
xref: uniprot Q38D65 1491
xref: PTHR11711:SF30
organism: Trypanosoma brucei

uniprot P10986 314
type: UnificationXref
id: P10986
db: uniprot

uniprot C3Z3B1 1394
type: UnificationXref
id: C3Z3B1
db: uniprot

uniprot G2HIU2 1427
type: UnificationXref
id: G2HIU2
db: uniprot

CREB binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot F1PY87 1004
organism: Canis lupus familiaris

uniprot O35397 1118
type: UnificationXref
id: O35397
db: uniprot

uniprot Q6NYD8 1504
type: UnificationXref
id: Q6NYD8
db: uniprot

uniprot O14727 1113
type: UnificationXref
id: O14727
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q6RUV5 1288
organism: Rattus norvegicus

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot E1BW56 676
organism: Gallus gallus

PTHR11886:SF2
type: RelationshipXref
id: PTHR11886:SF2
db: PANTHER Family
relationship type: By Homology

uniprot F7DMP6 1189
type: UnificationXref
id: F7DMP6
db: uniprot

Rac-like GTP-binding protein 4
type: ProteinReference
xref: uniprot Q67VP4 1282
organism: Oryza sativa

N-CoR
type: ProteinReference
xref: P00770
standard name: Nuclear receptor co-repressor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.N-CoR
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Nuclear receptor corepressor 2
member entity reference: Nuclear receptor corepressor 1
member entity reference: Uncharacterized protein
member entity reference: Nuclear receptor co-repressor 2

uniprot O18840 301
type: UnificationXref
id: O18840
db: uniprot

uniprot Q6XNL8 395
type: UnificationXref
id: Q6XNL8
db: uniprot

uniprot A8IL29 1382
type: UnificationXref
id: A8IL29
db: uniprot

uniprot F6QWB7 272
type: UnificationXref
id: F6QWB7
db: uniprot

uniprot F7C5U3 1424
type: UnificationXref
id: F7C5U3
db: uniprot

uniprot F6QEI9 480
type: UnificationXref
id: F6QEI9
db: uniprot

GO GO:0030128 2
type: UnificationXref
id: GO:0030128
db: GO

uniprot Q01397 1318
type: UnificationXref
id: Q01397
db: uniprot

Huntingtin
type: DnaReference
xref: PTHR10170:SF10
organism: Homo sapiens

uniprot F6QTB5 1035
type: UnificationXref
id: F6QTB5
db: uniprot

Non-muscle actin 6.2
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot B3S5E4 231
organism: Trichoplax adhaerens

uniprot F6V553 482
type: UnificationXref
id: F6V553
db: uniprot

uniprot Q3MHM5 825
type: UnificationXref
id: Q3MHM5
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR44154:SF1
organism: Caenorhabditis elegans

uniprot F6RYL1 1127
type: UnificationXref
id: F6RYL1
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 23
evidence: Evidence 25
evidence: Evidence 22
evidence: Evidence 24
xref: uniprot A0A1D5QE40 21
xref: PTHR18966:SF407
organism: Macaca mulatta

uniprot P61206 1462
type: UnificationXref
id: P61206
db: uniprot

Dynein light chain
type: ProteinReference
xref: uniprot Q9LW74 581
xref: PTHR11886:SF72
organism: Arabidopsis thaliana

uniprot Q62871 547
type: UnificationXref
id: Q62871
db: uniprot

uniprot Q9VWZ3 587
type: UnificationXref
id: Q9VWZ3
db: uniprot

ncbitaxon 9598 51
type: UnificationXref
id: 9598
db: ncbitaxon

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot P04797 934
xref: PTHR10836:SF111
organism: Rattus norvegicus

uniprot P49186 607
type: UnificationXref
id: P49186
db: uniprot

uniprot H2Q9U2 98
type: UnificationXref
id: H2Q9U2
db: uniprot

AP-2 complex subunit alpha-2
type: ProteinReference
xref: uniprot P18484 889
xref: PTHR22780:SF30
organism: Rattus norvegicus

Actin-57B
type: ProteinReference
xref: PTHR11937:SF397
xref: uniprot P53501 331
organism: Drosophila melanogaster

ncbitaxon 83333 940
type: UnificationXref
id: 83333
db: ncbitaxon

uniprot Q19542 534
type: UnificationXref
id: Q19542
db: uniprot

uniprot Q22143 159
type: UnificationXref
id: Q22143
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

Complex (Arfaptin-2/ARF)
type: Complex
component stoichiometry: ARF s117 sa58 STOICHIOMETRY ID COMPLEX
component stoichiometry: Arfaptin 2 s116 sa57 STOICHIOMETRY ID COMPLEX
component: Arfaptin-2
component: ARF
feature: COMPLEX BINDING FEATURE s229 a312 1578
feature: COMPLEX BINDING FEATURE s229 a312 1576
cellular location: synapse

Pro-caspase 8
type: Protein
entity reference: Pro-caspase 8
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Tubulin beta chain
type: ProteinReference
xref: uniprot P32256 802
xref: PTHR11588:SF306
organism: Dictyostelium discoideum

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 200

Cytochrome c1, isoform A
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q9VRL0 1207
organism: Drosophila melanogaster

uniprot Q22036 158
type: UnificationXref
id: Q22036
db: uniprot

uniprot P10989 316
type: UnificationXref
id: P10989
db: uniprot

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 1306

ncbitaxon 10228 229
type: UnificationXref
id: 10228
db: ncbitaxon

uniprot O35646 144
type: UnificationXref
id: O35646
db: uniprot

uniprot Q9Y7Z2 1529
type: UnificationXref
id: Q9Y7Z2
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q3SYX9 1052
xref: PTHR12644:SF1
organism: Bos taurus

Protein kinase C and casein kinase substrate in neurons protein 1
type: ProteinReference
xref: uniprot A7MBI0 6
xref: PTHR23065:SF16
organism: Bos taurus

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot A8JHR9 907
organism: Chlamydomonas reinhardtii

Dynactin
type: ProteinReference
xref: P00781
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Dynactin
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dynactin subunit 1
member entity reference: Dynactin subunit 1 isoform 1
member entity reference: Dynactin, 150 kDa isoform
member entity reference: Uncharacterized protein

uniprot Q6DGK1 1500
type: UnificationXref
id: Q6DGK1
db: uniprot

uniprot Q2YDM1 1488
type: UnificationXref
id: Q2YDM1
db: uniprot

uniprot C4LXL1 1395
type: UnificationXref
id: C4LXL1
db: uniprot

uniprot F7AWC8 491
type: UnificationXref
id: F7AWC8
db: uniprot

Htt
type: Protein
entity reference: Htt
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa1 1581
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot E2RH71 464
type: UnificationXref
id: E2RH71
db: uniprot

uniprot Q9BY11 17
type: UnificationXref
id: Q9BY11
db: uniprot

uniprot Q9H4B7 865
type: UnificationXref
id: Q9H4B7
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MLK_2-RIGHT__MLK_2-_r26
controller: JNK-2

uniprot F6T022 1416
type: UnificationXref
id: F6T022
db: uniprot

uniprot O14815 141
type: UnificationXref
id: O14815
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 8

ncbitaxon 184922 209
type: UnificationXref
id: 184922
db: ncbitaxon

uniprot P45481 1011
type: UnificationXref
id: P45481
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase GAPCP1, chloroplastic
type: ProteinReference
xref: uniprot Q9SAJ6 997
organism: Arabidopsis thaliana

PTHR10183:SF280
type: RelationshipXref
id: PTHR10183:SF280
db: PANTHER Family
relationship type: By Homology

Putative oxidoreductase
type: DnaReference
xref: PTHR43677:SF4
organism: Streptomyces coelicolor

PTHR10183:SF284
type: RelationshipXref
id: PTHR10183:SF284
db: PANTHER Family
relationship type: By Homology

uniprot F6VTB5 41
type: UnificationXref
id: F6VTB5
db: uniprot

uniprot F6PI02 478
type: UnificationXref
id: F6PI02
db: uniprot

TRANSLATION_LEFT__HTT-RIGHT__Htt-_re77
type: TemplateReaction
product: Htt
xref: TRANSLATION
participant: HTT
participant: Htt
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

uniprot Q6DGB7 1284
type: UnificationXref
id: Q6DGB7
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 39

Actin, cytoskeletal 3B
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P18499 318
organism: Strongylocentrotus purpuratus

Cytoplasmic dynein 1 light intermediate chain 1
type: ProteinReference
xref: PTHR12688:SF2
xref: uniprot Q9Y6G9 589
organism: Homo sapiens

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot A9RDK9 910
organism: Physcomitrella patens

uniprot A0A2I3RV17 878
type: UnificationXref
id: A0A2I3RV17
db: uniprot

uniprot F1PRG4 1159
type: UnificationXref
id: F1PRG4
db: uniprot

uniprot F1MRU4 470
type: UnificationXref
id: F1MRU4
db: uniprot

Truncated Htt
type: ProteinReference
xref: P00761
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.TRUNCATED.Truncated_br_Htt
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES= Long Name: Truncated Htt Synonym: Synonym not specified Accession: P00761
member entity reference: Huntingtin
member entity reference: Uncharacterized protein

uniprot Q6R6I2 76
type: UnificationXref
id: Q6R6I2
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__HTT-RIGHT__HTT-_re76
control type: ACTIVATION
controller: Iron

uniprot F7DUR2 689
type: UnificationXref
id: F7DUR2
db: uniprot

uniprot A0A0D1CG61 1374
type: UnificationXref
id: A0A0D1CG61
db: uniprot

PTHR10454:SF198
type: RelationshipXref
id: PTHR10454:SF198
db: PANTHER Family
relationship type: By Homology

Chromosome 1, whole genome shotgun sequence
type: ProteinReference
xref: uniprot A0A0D1CG61 1374
xref: PTHR11711:SF30
organism: Ustilago maydis

uniprot F1QI24 126
type: UnificationXref
id: F1QI24
db: uniprot

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF409
xref: uniprot A0A2I3TS83 192
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10676:SF358
xref: uniprot F7AZV1 492
organism: Macaca mulatta

PSD 95 s101 sa50 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PSD-95
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF174
xref: uniprot F1P0L4 633
organism: Gallus gallus

uniprot A8WQL1 909
type: UnificationXref
id: A8WQL1
db: uniprot

uniprot F6QED1 882
type: UnificationXref
id: F6QED1
db: uniprot

ADP-ribosylation factor 2
type: ProteinReference
xref: PTHR11711:SF110
xref: uniprot P40945 1454
organism: Drosophila melanogaster

ADP ribosylation factor-like GTPase 4C
type: ProteinReference
xref: uniprot Q28J03 1487
xref: PTHR11711:SF119
organism: Xenopus tropicalis

ADP-ribosylation factor 3
type: ProteinReference
xref: uniprot P40940 1453
xref: PTHR11711:SF372
organism: Arabidopsis thaliana

ADP-ribosylation factor 2b
type: ProteinReference
xref: uniprot F1QV75 1408
xref: PTHR11711:SF119
organism: Danio rerio

ADP-ribosylation factor 6
type: ProteinReference
xref: uniprot P40946 1455
xref: PTHR11711:SF322
organism: Drosophila melanogaster

Actin-3
type: ProteinReference
xref: uniprot Q10AZ4 367
xref: PTHR11937:SF411
organism: Oryza sativa

uniprot P11076 1445
type: UnificationXref
id: P11076
db: uniprot

uniprot H2QS82 776
type: UnificationXref
id: H2QS82
db: uniprot

uniprot Q6IQL9 389
type: UnificationXref
id: Q6IQL9
db: uniprot

Complex (Htt/HAP1)
type: Complex
component stoichiometry: Htt s112 sa55 STOICHIOMETRY ID COMPLEX
component stoichiometry: HAP1 s113 sa56 STOICHIOMETRY ID COMPLEX
component: HAP1
component: Htt
feature: COMPLEX BINDING FEATURE s225 a308 1644
feature: COMPLEX BINDING FEATURE s225 a308 1646
cellular location: synapse

ncbitaxon 227321 321
type: UnificationXref
id: 227321
db: ncbitaxon

Discs large MAGUK scaffold protein 4
type: ProteinReference
xref: PTHR23119:SF33
xref: uniprot F1MM66 1074
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r46 1686
type: Stoichiometry
physical entity: Truncated Htt
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r46 1687
type: Stoichiometry
physical entity: Truncated Htt
stoichiometric coefficient: 8.0

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot B8C8B4 740
organism: Thalassiosira pseudonana

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: PTHR10836:SF111
xref: uniprot P10096 944
organism: Bos taurus

uniprot S4R1W1 1000
type: UnificationXref
id: S4R1W1
db: uniprot

Glutamate ionotropic receptor NMDA type subunit 3A
type: ProteinReference
evidence: Evidence 27
evidence: Evidence 22
xref: PTHR18966:SF397
xref: uniprot H2QZZ2 52
organism: Pan troglodytes

ncbitaxon 100226 987
type: UnificationXref
id: 100226
db: ncbitaxon

Dynein heavy chain 8, axonemal
type: ProteinReference
xref: uniprot Q96JB1 575
xref: PTHR10676:SF361
organism: Homo sapiens

Apoptotic protease-activating factor 1
type: ProteinReference
xref: PTHR22845:SF5
xref: uniprot F1MUW4 1110
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q1NH21 1154
xref: PTHR24356:SF176
organism: Bos taurus

uniprot F6UA63 279
type: UnificationXref
id: F6UA63
db: uniprot

PTHR23235:SF15
type: RelationshipXref
id: PTHR23235:SF15
db: PANTHER Family
relationship type: By Homology

Dynein heavy chain 5, axonemal
type: ProteinReference
xref: PTHR10676:SF344
xref: uniprot Q8TE73 568
organism: Homo sapiens

Brain-derived neurotrophic factor
type: DnaReference
xref: PTHR11589:SF3
organism: Danio rerio

uniprot Q9U1E8 412
type: UnificationXref
id: Q9U1E8
db: uniprot

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 963

uniprot O88487 516
type: UnificationXref
id: O88487
db: uniprot

Putative oxidoreductase
type: DnaReference
organism: Streptomyces coelicolor

uniprot G3X6J7 692
type: UnificationXref
id: G3X6J7
db: uniprot

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 940

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot A2EM29 901
organism: Trichomonas vaginalis

uniprot Q96F07 711
type: UnificationXref
id: Q96F07
db: uniprot

uniprot F7EDU0 130
type: UnificationXref
id: F7EDU0
db: uniprot

STATE_TRANSITION_LEFT__MAPKK7-RIGHT__MAPKK7-_r15
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 1675
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 1674
left: MAPKK7
interaction type: STATE_TRANSITION
right: MAPKK7

uniprot Q9LG11 1019
type: UnificationXref
id: Q9LG11
db: uniprot

uniprot D4A1V1 1084
type: UnificationXref
id: D4A1V1
db: uniprot

uniprot Q9FWQ5 1016
type: UnificationXref
id: Q9FWQ5
db: uniprot

uniprot P08574 1195
type: UnificationXref
id: P08574
db: uniprot

ncbitaxon 54126 191
type: UnificationXref
id: 54126
db: ncbitaxon

uniprot H3F5B4 298
type: UnificationXref
id: H3F5B4
db: uniprot

uniprot Q9JHX4 1109
type: UnificationXref
id: Q9JHX4
db: uniprot

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 186

uniprot F7G485 642
type: UnificationXref
id: F7G485
db: uniprot

uniprot Q07009 156
type: UnificationXref
id: Q07009
db: uniprot

PTHR11588:SF329
type: RelationshipXref
id: PTHR11588:SF329
db: PANTHER Family
relationship type: By Homology

uniprot A4IF78 1135
type: UnificationXref
id: A4IF78
db: uniprot

PTHR11588:SF325
type: RelationshipXref
id: PTHR11588:SF325
db: PANTHER Family
relationship type: By Homology

N-Wasp
type: Protein
entity reference: N-Wasp
feature: COMPLEX PARTICIPANT BINDING FEATURE s79 sa33 1593
cellular location: clathrin coat of endocytic vesicle
comment: SPECIES_TYPE=PROTEIN

PTHR11588:SF321
type: RelationshipXref
id: PTHR11588:SF321
db: PANTHER Family
relationship type: By Homology

uniprot Q56A35 376
type: UnificationXref
id: Q56A35
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: PTHR48013:SF17
xref: uniprot Q4KSH7 1308
organism: Rattus norvegicus

uniprot G2HG77 499
type: UnificationXref
id: G2HG77
db: uniprot

PTHR10454:SF162
type: RelationshipXref
id: PTHR10454:SF162
db: PANTHER Family
relationship type: By Homology

uniprot P19146 1447
type: UnificationXref
id: P19146
db: uniprot

Calpain-5
type: ProteinReference
xref: PTHR10183:SF402
xref: uniprot O08688 140
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6XP81 1165
organism: Xenopus tropicalis

uniprot C3YP58 247
type: UnificationXref
id: C3YP58
db: uniprot

PTHR11588:SF314
type: RelationshipXref
id: PTHR11588:SF314
db: PANTHER Family
relationship type: By Homology

uniprot F1MYJ4 1158
type: UnificationXref
id: F1MYJ4
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A7RU31 202
organism: Nematostella vectensis

PTHR11588:SF310
type: RelationshipXref
id: PTHR11588:SF310
db: PANTHER Family
relationship type: By Homology

uniprot F7HTD6 772
type: UnificationXref
id: F7HTD6
db: uniprot

uniprot P27726 955
type: UnificationXref
id: P27726
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot Q4QBZ6 832
organism: Leishmania major

uniprot P13393 1334
type: UnificationXref
id: P13393
db: uniprot

AGAP000320-PA
type: ProteinReference
xref: PTHR12442:SF22
xref: uniprot Q7QF61 562
organism: Anopheles gambiae

Tubulin beta-2 chain
type: ProteinReference
xref: uniprot P61857 809
xref: PTHR11588:SF314
organism: Drosophila melanogaster

uniprot F7D7Y7 767
type: UnificationXref
id: F7D7Y7
db: uniprot

uniprot H2QQN4 507
type: UnificationXref
id: H2QQN4
db: uniprot

uniprot Q6TYS2 394
type: UnificationXref
id: Q6TYS2
db: uniprot

Actin-5C
type: ProteinReference
xref: uniprot P84185 363
xref: PTHR11937:SF387
organism: Anopheles gambiae

PTHR11588:SF306
type: RelationshipXref
id: PTHR11588:SF306
db: PANTHER Family
relationship type: By Homology

uniprot W4Z8M4 594
type: UnificationXref
id: W4Z8M4
db: uniprot

uniprot F7CS79 43
type: UnificationXref
id: F7CS79
db: uniprot

uniprot P00358 930
type: UnificationXref
id: P00358
db: uniprot

Ras-related protein RABA1a
type: ProteinReference
xref: uniprot P28185 1026
organism: Arabidopsis thaliana

uniprot A9JRY8 1212
type: UnificationXref
id: A9JRY8
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR11937:SF473
xref: uniprot A7SEB1 207
organism: Nematostella vectensis

PolyQ Htt
type: Protein
entity reference: PolyQ Htt
feature: PolyQ Htt s45 sa16 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa16 1595
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 20

PTHR11588:SF301
type: RelationshipXref
id: PTHR11588:SF301
db: PANTHER Family
relationship type: By Homology

uniprot F6UMF1 1312
type: UnificationXref
id: F6UMF1
db: uniprot

Cytoplasmatic actin
type: ProteinReference
xref: uniprot E9FZ00 260
xref: PTHR11937:SF387
organism: Daphnia pulex

uniprot F7GL73 292
type: UnificationXref
id: F7GL73
db: uniprot

uniprot Q9ERD7 864
type: UnificationXref
id: Q9ERD7
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

uniprot F1A1N6 1405
type: UnificationXref
id: F1A1N6
db: uniprot

Os12g0580300 protein
type: ProteinReference
xref: uniprot Q2QN41 1346
xref: PTHR10126:SF50
organism: Oryza sativa

uniprot C3XYC8 241
type: UnificationXref
id: C3XYC8
db: uniprot

Probable tubulin beta chain CG32396
type: ProteinReference
xref: uniprot Q9VRX3 866
xref: PTHR11588:SF293
organism: Drosophila melanogaster

uniprot E2REK9 462
type: UnificationXref
id: E2REK9
db: uniprot

uniprot A9TYG6 222
type: UnificationXref
id: A9TYG6
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A7SEA7 206
organism: Nematostella vectensis

PARTICIPANT STOICHIOMETRY r56 1735
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r56 1734
type: Stoichiometry
physical entity: GAPDH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r56 1733
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 1.0

uniprot Q8K3K8 1142
type: UnificationXref
id: Q8K3K8
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR11711:SF322
xref: uniprot A7S615 1380
organism: Nematostella vectensis

ADP ribosylation factor 1
type: ProteinReference
xref: uniprot F1NN08 1406
xref: PTHR11711:SF357
organism: Gallus gallus

uniprot Q7F270 1511
type: UnificationXref
id: Q7F270
db: uniprot

uniprot P47809 616
type: UnificationXref
id: P47809
db: uniprot

Tumor necrosis factor alpha-induced protein 8
type: ProteinReference
xref: uniprot A4IF78 1135
organism: Bos taurus

TATA-box-binding protein
type: ProteinReference
xref: uniprot Q7SXL3 1354
xref: PTHR10126:SF42
organism: Danio rerio

PTHR10183:SF268
type: RelationshipXref
id: PTHR10183:SF268
db: PANTHER Family
relationship type: By Homology

PTHR11588:SF361
type: RelationshipXref
id: PTHR11588:SF361
db: PANTHER Family
relationship type: By Homology

ADP-Ribosylation Factor related
type: ProteinReference
xref: PTHR11711:SF322
xref: uniprot Q9U2S4 1528
organism: Caenorhabditis elegans

PTHR11588:SF365
type: RelationshipXref
id: PTHR11588:SF365
db: PANTHER Family
relationship type: By Homology

uniprot F7GY91 1235
type: UnificationXref
id: F7GY91
db: uniprot

Nuclear receptor corepressor 1
type: ProteinReference
xref: uniprot E2RKW5 1366
xref: PTHR13992:SF5
organism: Canis lupus familiaris

Uncharacterized protein
type: DnaReference
xref: PTHR11256:SF42
organism: Macaca mulatta

uniprot P60952 1256
type: UnificationXref
id: P60952
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR46454:SF2
xref: uniprot A1ZAD3 446
organism: Drosophila melanogaster

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot O15511 1045
xref: PTHR12644:SF1
organism: Homo sapiens

GRIK1 protein
type: ProteinReference
xref: uniprot A2VE57 624
xref: PTHR18966:SF36
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF200
xref: uniprot G3X7B5 1167
organism: Bos taurus

Calpain-7
type: ProteinReference
xref: PTHR46143:SF1
xref: uniprot H9ESM2 136
organism: Macaca mulatta

Cdc42 protein, putative
type: ProteinReference
xref: uniprot B7PHY7 1214
organism: Ixodes scapularis

PTHR11588:SF357
type: RelationshipXref
id: PTHR11588:SF357
db: PANTHER Family
relationship type: By Homology

uniprot E2RCG1 1068
type: UnificationXref
id: E2RCG1
db: uniprot

Apoptosis regulator BAX
type: DnaReference
xref: PTHR11256:SF42
organism: Bos taurus

uniprot A0A2I3TS83 192
type: UnificationXref
id: A0A2I3TS83
db: uniprot

uniprot A2FA04 193
type: UnificationXref
id: A2FA04
db: uniprot

ncbitaxon 35128 741
type: UnificationXref
id: 35128
db: ncbitaxon

uniprot A0A452J7P8 623
type: UnificationXref
id: A0A452J7P8
db: uniprot

ADP-ribosylation factor 4
type: ProteinReference
xref: PTHR11711:SF110
xref: uniprot Q3SZF2 1492
organism: Bos taurus

uniprot Q6SJR1 183
type: UnificationXref
id: Q6SJR1
db: uniprot

uniprot P20807 154
type: UnificationXref
id: P20807
db: uniprot

uniprot P17871 1335
type: UnificationXref
id: P17871
db: uniprot

Protein CBR-CYC-1
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot A8X623 1185
organism: Caenorhabditis briggsae

uniprot Q7Q1Z0 558
type: UnificationXref
id: Q7Q1Z0
db: uniprot

uniprot A7ER45 904
type: UnificationXref
id: A7ER45
db: uniprot

HAP1 s71 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: HAP1
stoichiometric coefficient: 1.0

TATA-box-binding protein 2
type: ProteinReference
xref: uniprot P28148 1339
xref: PTHR10126:SF54
organism: Arabidopsis thaliana

uniprot A8IXZ0 730
type: UnificationXref
id: A8IXZ0
db: uniprot

Rac family small GTPase 3b
type: ProteinReference
xref: PTHR24072:SF301
xref: uniprot A9JRY8 1212
organism: Danio rerio

uniprot Q01098 65
type: UnificationXref
id: Q01098
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZIB9 1216
organism: Branchiostoma floridae

uniprot F6R8N3 1163
type: UnificationXref
id: F6R8N3
db: uniprot

uniprot Q6P2U5 1505
type: UnificationXref
id: Q6P2U5
db: uniprot

RHOG isoform 1
type: ProteinReference
xref: uniprot K7CGY0 1240
xref: PTHR24072:SF158
organism: Pan troglodytes

uniprot F7FFR0 771
type: UnificationXref
id: F7FFR0
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot F4P7H8 758
xref: PTHR11588:SF9
organism: Batrachochytrium dendrobatidis

PTHR11588:SF330
type: RelationshipXref
id: PTHR11588:SF330
db: PANTHER Family
relationship type: By Homology

Cytoplasmic FMR1-interacting protein 1
type: ProteinReference
xref: uniprot Q7L576 707
organism: Homo sapiens

uniprot C3XYD3 242
type: UnificationXref
id: C3XYD3
db: uniprot

PTHR11588:SF334
type: RelationshipXref
id: PTHR11588:SF334
db: PANTHER Family
relationship type: By Homology

PTHR11588:SF339
type: RelationshipXref
id: PTHR11588:SF339
db: PANTHER Family
relationship type: By Homology

Protein CBR-DHC-1
type: ProteinReference
xref: uniprot A8XF10 449
xref: PTHR10676:SF314
organism: Caenorhabditis briggsae

Protein CBG02167
type: ProteinReference
xref: uniprot A8WS37 214
xref: PTHR11937:SF470
organism: Caenorhabditis briggsae

uniprot F7EZ93 1076
type: UnificationXref
id: F7EZ93
db: uniprot

uniprot O14733 1307
type: UnificationXref
id: O14733
db: uniprot

ADP-ribosylation factor 1
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot P11076 1445
organism: Saccharomyces cerevisiae

PTHR11588:SF253
type: RelationshipXref
id: PTHR11588:SF253
db: PANTHER Family
relationship type: By Homology

uniprot H2Q1A9 295
type: UnificationXref
id: H2Q1A9
db: uniprot

uniprot Q9Z518 999
type: UnificationXref
id: Q9Z518
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__BDNF-RIGHT__BDNF-_re74
control type: ACTIVATION
controller: Htt

uniprot Q7RVM2 1516
type: UnificationXref
id: Q7RVM2
db: uniprot

Protein CBG02161
type: ProteinReference
xref: PTHR11937:SF471
xref: uniprot A8WS32 212
organism: Caenorhabditis briggsae

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: Complex (Fos protein/c-Jun)

uniprot P40616 1451
type: UnificationXref
id: P40616
db: uniprot

Protein CBG02162
type: ProteinReference
xref: PTHR11937:SF471
xref: uniprot A8WS33 213
organism: Caenorhabditis briggsae

uniprot E9FWY0 749
type: UnificationXref
id: E9FWY0
db: uniprot

Rho-related GTP-binding protein RhoQ
type: ProteinReference
xref: uniprot P17081 1244
xref: PTHR24072:SF13
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZHN2 249
xref: PTHR11937:SF446
organism: Branchiostoma floridae

uniprot Q76FS2 851
type: UnificationXref
id: Q76FS2
db: uniprot

uniprot Q9ER71 1298
type: UnificationXref
id: Q9ER71
db: uniprot

uniprot Q43594 829
type: UnificationXref
id: Q43594
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF446
xref: uniprot C3ZHN4 250
organism: Branchiostoma floridae

PTHR11589:SF3
type: RelationshipXref
id: PTHR11589:SF3
db: PANTHER Family
relationship type: By Homology

uniprot Q6NZ01 600
type: UnificationXref
id: Q6NZ01
db: uniprot

uniprot Q6P8G3 393
type: UnificationXref
id: Q6P8G3
db: uniprot

Htt s112 sa55 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Htt
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot F6RFW8 274
organism: Monodelphis domestica

ADP-ribosylation factor 1
type: ProteinReference
xref: uniprot B7QCW2 1393
xref: PTHR11711:SF381
organism: Ixodes scapularis

CBP
type: Protein
entity reference: CBP
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PTHR11588:SF279
type: RelationshipXref
id: PTHR11588:SF279
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot J9NWP6 1440
organism: Canis lupus familiaris

uniprot P36579 1449
type: UnificationXref
id: P36579
db: uniprot

SIN3 transcription regulator family member A
type: ProteinReference
xref: PTHR12346:SF2
xref: uniprot F6TAI6 92
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5PRH4 1531
xref: PTHR22826:SF49
organism: Gallus gallus

uniprot Q9SNK3 998
type: UnificationXref
id: Q9SNK3
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF55
xref: uniprot F6TYN8 760
organism: Ornithorhynchus anatinus

Rac
type: Protein
entity reference: Rac
feature: COMPLEX PARTICIPANT BINDING FEATURE s96 sa47 1653
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

PTHR10454:SF206
type: RelationshipXref
id: PTHR10454:SF206
db: PANTHER Family
relationship type: By Homology

ADP-Ribosylation factor
type: ProteinReference
xref: uniprot F4NRM0 1411
xref: PTHR11711:SF30
organism: Batrachochytrium dendrobatidis

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot A0A3P6PCS5 1030
xref: PTHR10709:SF2
organism: Caenorhabditis elegans

PTHR11588:SF273
type: RelationshipXref
id: PTHR11588:SF273
db: PANTHER Family
relationship type: By Homology

uniprot O96015 518
type: UnificationXref
id: O96015
db: uniprot

uniprot F1P3C8 474
type: UnificationXref
id: F1P3C8
db: uniprot

uniprot A0A1D5Q7H4 669
type: UnificationXref
id: A0A1D5Q7H4
db: uniprot

uniprot P99024 815
type: UnificationXref
id: P99024
db: uniprot

uniprot F4HXI5 1410
type: UnificationXref
id: F4HXI5
db: uniprot

Dynein cytoplasmic 1 light intermediate chain 1
type: ProteinReference
xref: uniprot F6QEI9 480
xref: PTHR12688:SF2
organism: Xenopus tropicalis

uniprot B8C8B4 740
type: UnificationXref
id: B8C8B4
db: uniprot

ncbitaxon 251221 1536
type: UnificationXref
id: 251221
db: ncbitaxon

Htt s72 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Htt
stoichiometric coefficient: 1.0

uniprot A0A0B4K765 85
type: UnificationXref
id: A0A0B4K765
db: uniprot

Tubulin beta-1 chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot Q24560 820
organism: Drosophila melanogaster

Kainate receptor s103 sa51 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Kainate receptor
stoichiometric coefficient: 1.0

uniprot Q6NT85 1503
type: UnificationXref
id: Q6NT85
db: uniprot

PTHR11588:SF280
type: RelationshipXref
id: PTHR11588:SF280
db: PANTHER Family
relationship type: By Homology

uniprot P51131 1196
type: UnificationXref
id: P51131
db: uniprot

uniprot P51823 1458
type: UnificationXref
id: P51823
db: uniprot

TRANSLATION
type: RelationshipTypeVocabulary

uniprot W4Z8M3 593
type: UnificationXref
id: W4Z8M3
db: uniprot

uniprot P84083 1480
type: UnificationXref
id: P84083
db: uniprot

Tubulin beta-1 chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot P10653 795
organism: Emericella nidulans

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF84
xref: uniprot H2Q713 501
organism: Pan troglodytes

PTHR11937:SF176
type: RelationshipXref
id: PTHR11937:SF176
db: PANTHER Family
relationship type: By Homology

PTHR11588:SF295
type: RelationshipXref
id: PTHR11588:SF295
db: PANTHER Family
relationship type: By Homology

Complex (Hip-12/Hip-1)
type: Complex
component stoichiometry: Hip 1 s81 sa35 STOICHIOMETRY ID COMPLEX
component stoichiometry: Hip 12 s80 sa34 STOICHIOMETRY ID COMPLEX
component: Hip-1
component: Hip-12
feature: COMPLEX BINDING FEATURE s153 a201 1556
feature: COMPLEX BINDING FEATURE s153 a201 1554
cellular location: synapse

STATE_TRANSITION_LEFT__Complex__Rac_GDP_-_GTP-RIGHT__Complex__Rac_GTP_-_GDP-_r75
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 1701
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 1700
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 1699
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 1702
left: Complex (Rac/GDP)
left: GTP
interaction type: STATE_TRANSITION
right: GDP
right: Complex (Rac/GTP)

PTHR11588:SF293
type: RelationshipXref
id: PTHR11588:SF293
db: PANTHER Family
relationship type: By Homology

Glutamate receptor ionotropic, kainate 4
type: ProteinReference
xref: PTHR18966:SF171
xref: uniprot Q8BMF5 659
organism: Mus musculus

ADP ribosylation factor like GTPase 1
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot H2Q6P9 1430
organism: Pan troglodytes

PTHR11588:SF291
type: RelationshipXref
id: PTHR11588:SF291
db: PANTHER Family
relationship type: By Homology

Tubulin beta chain
type: ProteinReference
xref: uniprot F7F082 770
xref: PTHR11588:SF61
organism: Monodelphis domestica

uniprot A7S615 1380
type: UnificationXref
id: A7S615
db: uniprot

Caspase-3
type: ProteinReference
xref: uniprot P70677 1151
xref: PTHR10454:SF198
organism: Mus musculus

PTHR11937:SF175
type: RelationshipXref
id: PTHR11937:SF175
db: PANTHER Family
relationship type: By Homology

Calpain-3
type: ProteinReference
xref: uniprot Q64691 162
xref: PTHR10183:SF329
organism: Mus musculus

uniprot F6THF0 1228
type: UnificationXref
id: F6THF0
db: uniprot

uniprot Q9WU42 1372
type: UnificationXref
id: Q9WU42
db: uniprot

Dynein light chain
type: ProteinReference
xref: uniprot E2RK00 465
xref: PTHR11886:SF91
organism: Canis lupus familiaris

PTHR11937:SF168
type: RelationshipXref
id: PTHR11937:SF168
db: PANTHER Family
relationship type: By Homology

CD42_CHICK Cell division control protein 42 homolog (G25K GTP-binding protein)MODA
type: ProteinReference
xref: uniprot G5EAY4 1236
organism: Emericella nidulans

GRIK1 isoform 7
type: ProteinReference
xref: uniprot A0A2I3T979 621
xref: PTHR18966:SF36
organism: Pan troglodytes

uniprot Q9VWA1 667
type: UnificationXref
id: Q9VWA1
db: uniprot

uniprot P18484 889
type: UnificationXref
id: P18484
db: uniprot

uniprot A0A1D5RB13 1066
type: UnificationXref
id: A0A1D5RB13
db: uniprot

uniprot C3XYC5 238
type: UnificationXref
id: C3XYC5
db: uniprot

uniprot P45960 807
type: UnificationXref
id: P45960
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q4KLF8 1053
xref: PTHR12644:SF1
organism: Rattus norvegicus

ADP ribosylation factor like GTPase 4A
type: ProteinReference
xref: PTHR11711:SF139
xref: uniprot H2QZJ8 1436
organism: Pan troglodytes

PTHR11937:SF162
type: RelationshipXref
id: PTHR11937:SF162
db: PANTHER Family
relationship type: By Homology

uniprot F1MX23 1179
type: UnificationXref
id: F1MX23
db: uniprot

ADP-ribosylation factor-like protein 4C
type: ProteinReference
xref: uniprot F7C5U3 1424
xref: PTHR11711:SF119
organism: Macaca mulatta

uniprot Q5AND9 1496
type: UnificationXref
id: Q5AND9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SY88 1415
xref: PTHR11711:SF357
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot H3FK05 1239
organism: Pristionchus pacificus

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot O43133 1333
organism: Candida albicans

Glutamate ionotropic receptor NMDA type subunit 2A
type: ProteinReference
evidence: Evidence 23
evidence: Evidence 25
evidence: Evidence 22
evidence: Evidence 24
xref: uniprot F6YLB3 42
xref: PTHR18966:SF407
organism: Monodelphis domestica

PTHR11937:SF154
type: RelationshipXref
id: PTHR11937:SF154
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF150
type: RelationshipXref
id: PTHR11937:SF150
db: PANTHER Family
relationship type: By Homology

uniprot Q9Y618 1373
type: UnificationXref
id: Q9Y618
db: uniprot

uniprot P00125 1192
type: UnificationXref
id: P00125
db: uniprot

PTHR11588:SF88
type: RelationshipXref
id: PTHR11588:SF88
db: PANTHER Family
relationship type: By Homology

uniprot P18499 318
type: UnificationXref
id: P18499
db: uniprot

ADP ribosylation factor like GTPase 4C
type: ProteinReference
xref: uniprot H2QJN7 1433
xref: PTHR11711:SF119
organism: Pan troglodytes

Calpain small subunit 2
type: ProteinReference
xref: PTHR46735:SF4
xref: uniprot Q96L46 169
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r67 1713
type: Stoichiometry
physical entity: Actin
stoichiometric coefficient: 8.0

AGAP009568-PA (Fragment)
type: ProteinReference
xref: PTHR10676:SF310
xref: uniprot Q7Q1Z0 558
organism: Anopheles gambiae

uniprot F7ESZ6 1233
type: UnificationXref
id: F7ESZ6
db: uniprot

PARTICIPANT STOICHIOMETRY r67 1712
type: Stoichiometry
physical entity: Actin
stoichiometric coefficient: 1.0

PTHR11937:SF149
type: RelationshipXref
id: PTHR11937:SF149
db: PANTHER Family
relationship type: By Homology

TRUNCATION
type: RelationshipTypeVocabulary

Uncharacterized protein
type: ProteinReference
xref: PTHR12346:SF2
xref: uniprot E1BX21 88
organism: Gallus gallus

uniprot Q4KLF8 1053
type: UnificationXref
id: Q4KLF8
db: uniprot

Arf family GTPase
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot Q5AND9 1496
organism: Candida albicans

uniprot B7QCW2 1393
type: UnificationXref
id: B7QCW2
db: uniprot

Dynein light chain 4, axonemal
type: ProteinReference
xref: uniprot O96015 518
xref: PTHR11886:SF73
organism: Homo sapiens

Hip 12 s80 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Hip-12
stoichiometric coefficient: 1.0

uniprot F1MTR3 89
type: UnificationXref
id: F1MTR3
db: uniprot

Huntingtin
type: ProteinReference
xref: PTHR10170:SF10
xref: uniprot F1P7Y7 1020
organism: Canis lupus familiaris

TATA-box-binding protein
type: ProteinReference
xref: uniprot W4YA56 1363
xref: PTHR10126:SF42
organism: Strongylocentrotus purpuratus

uniprot A8X861 1327
type: UnificationXref
id: A8X861
db: uniprot

uniprot F6TSX6 921
type: UnificationXref
id: F6TSX6
db: uniprot

uniprot Q0UMY5 1483
type: UnificationXref
id: Q0UMY5
db: uniprot

uniprot P47825 182
type: UnificationXref
id: P47825
db: uniprot

uniprot F1QV75 1408
type: UnificationXref
id: F1QV75
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__PUMA-RIGHT__PUMA-_re69
control type: ACTIVATION
controller: p53

Gll1949 protein
type: DnaReference
organism: Gloeobacter violaceus

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot A8XT67 1031
xref: PTHR10709:SF2
organism: Caenorhabditis briggsae

DNAH3 isoform 1
type: ProteinReference
xref: PTHR10676:SF242
xref: uniprot H2QAQ0 502
organism: Pan troglodytes

Tubulin beta chain
type: ProteinReference
xref: uniprot F7E840 769
xref: PTHR11588:SF55
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot F7DMP6 1189
organism: Macaca mulatta

Nuclear receptor corepressor 1
type: ProteinReference
xref: uniprot Q4KKX4 1370
xref: PTHR13992:SF5
organism: Xenopus tropicalis

Actin s88 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Actin
stoichiometric coefficient: 8.0

uniprot Q13409 531
type: UnificationXref
id: Q13409
db: uniprot

uniprot P84185 363
type: UnificationXref
id: P84185
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 25
evidence: Evidence 22
xref: PTHR18966:SF382
xref: uniprot F1NMB0 35
organism: Gallus gallus

Neural Wiskott-Aldrich syndrome protein
type: ProteinReference
xref: uniprot O00401 1071
xref: PTHR23202:SF39
organism: Homo sapiens

uniprot Q8TTZ7 1357
type: UnificationXref
id: Q8TTZ7
db: uniprot

PARTICIPANT STOICHIOMETRY r58 1730
type: Stoichiometry
physical entity: Hip-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 1731
type: Stoichiometry
physical entity: Hippi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 1732
type: Stoichiometry
physical entity: Complex (Hip-1/Hippi)
stoichiometric coefficient: 1.0

uniprot C7G3L5 626
type: UnificationXref
id: C7G3L5
db: uniprot

uniprot P25858 954
type: UnificationXref
id: P25858
db: uniprot

Dynein heavy chain at 36C
type: ProteinReference
xref: PTHR10676:SF310
xref: uniprot Q9VJC6 586
organism: Drosophila melanogaster

ADP-ribosylation factor 4-like
type: ProteinReference
xref: PTHR11711:SF137
xref: uniprot B2RZ70 1391
organism: Rattus norvegicus

uniprot P68134 356
type: UnificationXref
id: P68134
db: uniprot

uniprot D3ZUY8 881
type: UnificationXref
id: D3ZUY8
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot Q7JJU6 853
xref: PTHR11588:SF61
organism: Pan troglodytes

uniprot Q28259 965
type: UnificationXref
id: Q28259
db: uniprot

uniprot Q6ZSI9 163
type: UnificationXref
id: Q6ZSI9
db: uniprot

PTHR11588:SF43
type: RelationshipXref
id: PTHR11588:SF43
db: PANTHER Family
relationship type: By Homology

uniprot F7F6A6 1087
type: UnificationXref
id: F7F6A6
db: uniprot

uniprot F6T5J5 1311
type: UnificationXref
id: F6T5J5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__c_Jun-RIGHT__c_Jun-_r18
controller: JNK-2

PTHR11937:SF193
type: RelationshipXref
id: PTHR11937:SF193
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF192
type: RelationshipXref
id: PTHR11937:SF192
db: PANTHER Family
relationship type: By Homology

Glutamate receptor ionotropic, NMDA 2D
type: ProteinReference
evidence: Evidence 49
evidence: Evidence 54
evidence: Evidence 55
xref: uniprot O15399 53
xref: PTHR18966:SF385
organism: Homo sapiens

uniprot H2Q1B8 133
type: UnificationXref
id: H2Q1B8
db: uniprot

uniprot P01101 428
type: UnificationXref
id: P01101
db: uniprot

uniprot P40945 1454
type: UnificationXref
id: P40945
db: uniprot

uniprot F7EQF1 1313
type: UnificationXref
id: F7EQF1
db: uniprot

uniprot A7SEA7 206
type: UnificationXref
id: A7SEA7
db: uniprot

Protein pirA
type: ProteinReference
xref: uniprot Q6UK63 706
organism: Dictyostelium discoideum

TATA-box-binding protein 2
type: ProteinReference
xref: uniprot C4M7H7 1328
xref: PTHR10126:SF42
organism: Entamoeba histolytica

PTHR11937:SF184
type: RelationshipXref
id: PTHR11937:SF184
db: PANTHER Family
relationship type: By Homology

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q7Q1U8 979
organism: Anopheles gambiae

uniprot F6Z8M9 1421
type: UnificationXref
id: F6Z8M9
db: uniprot

uniprot Q61626 657
type: UnificationXref
id: Q61626
db: uniprot

AP-2 complex subunit alpha-2
type: ProteinReference
xref: uniprot Q0VCK5 892
xref: PTHR22780:SF30
organism: Bos taurus

PTHR11588:SF55
type: RelationshipXref
id: PTHR11588:SF55
db: PANTHER Family
relationship type: By Homology

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 11

uniprot Q65XH8 385
type: UnificationXref
id: Q65XH8
db: uniprot

GTPase cRac1A
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q6LC82 1287
organism: Gallus gallus

uniprot A0A167VDT2 668
type: UnificationXref
id: A0A167VDT2
db: uniprot

uniprot F1P630 602
type: UnificationXref
id: F1P630
db: uniprot

uniprot P10987 315
type: UnificationXref
id: P10987
db: uniprot

uniprot A0A3Q1M3Y3 1310
type: UnificationXref
id: A0A3Q1M3Y3
db: uniprot

BCL2-associated X, apoptosis regulator a
type: DnaReference
organism: Danio rerio

PTHR11588:SF61
type: RelationshipXref
id: PTHR11588:SF61
db: PANTHER Family
relationship type: By Homology

uniprot Q6P9T8 844
type: UnificationXref
id: Q6P9T8
db: uniprot

Actin-related protein 2/3 complex subunit 1A
type: ProteinReference
xref: uniprot O80856 1046
xref: PTHR10709:SF2
organism: Arabidopsis thaliana

Tubulin beta-1 chain
type: ProteinReference
xref: PTHR11588:SF112
xref: uniprot A2AQ07 721
organism: Mus musculus

uniprot F6T7D0 1006
type: UnificationXref
id: F6T7D0
db: uniprot

Os12g0163700 protein
type: ProteinReference
xref: uniprot Q0IPW3 366
xref: PTHR11937:SF474
organism: Oryza sativa

uniprot Q9HF56 1300
type: UnificationXref
id: Q9HF56
db: uniprot

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot D4A8H8 674
organism: Rattus norvegicus

Hip-1
type: Protein
entity reference: Hip-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s83 sa37 1623
cellular location: clathrin coat of endocytic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot P68034 353
type: UnificationXref
id: P68034
db: uniprot

uniprot A8Y4R0 217
type: UnificationXref
id: A8Y4R0
db: uniprot

PolyQ Htt
type: Protein
entity reference: PolyQ Htt
feature: PolyQ Htt s61 sa18 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s61 sa18 1599
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein racC
type: ProteinReference
xref: uniprot F0ZN94 1222
organism: Dictyostelium purpureum

ncbitaxon 36329 406
type: UnificationXref
id: 36329
db: ncbitaxon

SEK-1
type: Protein
entity reference: SEK-1
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Hip 1 s64 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Hip-1
stoichiometric coefficient: 1.0

uniprot Q9D0M5 577
type: UnificationXref
id: Q9D0M5
db: uniprot

ncbitaxon 9544 13
type: UnificationXref
id: 9544
db: ncbitaxon

Protein CBR-ACT-2
type: ProteinReference
xref: uniprot A8Y4Q9 216
xref: PTHR11937:SF471
organism: Caenorhabditis briggsae

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF293
xref: uniprot E9FWY0 749
organism: Daphnia pulex

Dynein axonemal heavy chain 5
type: ProteinReference
xref: PTHR10676:SF344
xref: uniprot H2QQN4 507
organism: Pan troglodytes

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot Q2PEE1 539
organism: Ciona intestinalis

Glutamate receptor, ionotropic, N-methyl D-aspartate 1a
type: ProteinReference
evidence: Evidence 22
xref: uniprot E7F101 32
xref: PTHR18966:SF400
organism: Danio rerio

uniprot H9ESM2 136
type: UnificationXref
id: H9ESM2
db: uniprot

uniprot F7A7I3 284
type: UnificationXref
id: F7A7I3
db: uniprot

PTHR12644:SF1
type: RelationshipXref
id: PTHR12644:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q4QI42 833
type: UnificationXref
id: Q4QI42
db: uniprot

PTHR12644:SF2
type: RelationshipXref
id: PTHR12644:SF2
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: Caspase 3

Rho-related GTP-binding protein RhoG
type: ProteinReference
xref: PTHR24072:SF158
xref: uniprot F6ZFI9 1230
organism: Macaca mulatta

Glyceraldehyde-3-phosphate dehydrogenase 1
type: ProteinReference
xref: uniprot P49433 957
organism: Synechocystis

SEK-1
type: Protein
entity reference: SEK-1
feature: ACTIVE 84
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot A6QP82 116
type: UnificationXref
id: A6QP82
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZZG9 283
xref: PTHR11937:SF168
organism: Monodelphis domestica

uniprot A8XW67 450
type: UnificationXref
id: A8XW67
db: uniprot

uniprot Q6P5M5 1506
type: UnificationXref
id: Q6P5M5
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot A8IXZ0 730
organism: Chlamydomonas reinhardtii

Ras-related protein Rac1
type: ProteinReference
xref: uniprot P40792 1252
organism: Drosophila melanogaster

Cdc42 homolog
type: ProteinReference
xref: uniprot P40793 1253
organism: Drosophila melanogaster

uniprot Q93J08 986
type: UnificationXref
id: Q93J08
db: uniprot

TRUNCATION_LEFT__Htt-RIGHT__Protein_fragment-_Truncated_Htt-_r22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 1741
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 1743
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 1742
left: Htt
interaction type: TRUNCATION
right: Truncated Htt
right: Protein fragment

uniprot A7RU31 202
type: UnificationXref
id: A7RU31
db: uniprot

ncbitaxon 9913 7
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot W4YRY2 592
type: UnificationXref
id: W4YRY2
db: uniprot

ADP-ribosylation factor 1
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot F1A1N6 1405
organism: Dictyostelium purpureum

uniprot P79734 703
type: UnificationXref
id: P79734
db: uniprot

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot F7GA51 691
organism: Macaca mulatta

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P47196 1171
organism: Rattus norvegicus

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P47197 1172
xref: PTHR24356:SF176
organism: Rattus norvegicus

uniprot F7EI91 424
type: UnificationXref
id: F7EI91
db: uniprot

Protein CBG23090
type: ProteinReference
xref: uniprot A8Y4R0 217
xref: PTHR11937:SF470
organism: Caenorhabditis briggsae

Glutamate ionotropic receptor kainate type subunit 3
type: ProteinReference
xref: PTHR18966:SF174
xref: uniprot F1PWT6 634
organism: Canis lupus familiaris

N-CoR
type: Protein
entity reference: N-CoR
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa13 1639
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot C3YMF1 744
type: UnificationXref
id: C3YMF1
db: uniprot

Actin, aortic smooth muscle
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot P62736 340
organism: Homo sapiens

uniprot F7D120 1075
type: UnificationXref
id: F7D120
db: uniprot

Brain-derived neurotrophic factor
type: ProteinReference
xref: uniprot P21237 596
xref: PTHR11589:SF3
organism: Mus musculus

Actin, aortic smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot P62739 342
organism: Bos taurus

uniprot Q6P5M7 1507
type: UnificationXref
id: Q6P5M7
db: uniprot

Actin, aortic smooth muscle
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot P62737 341
organism: Mus musculus

uniprot H2QMR3 506
type: UnificationXref
id: H2QMR3
db: uniprot

PolyQ Htt
type: Protein
entity reference: PolyQ Htt
feature: PolyQ Htt s2 a2 rs1
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot A8BEI6 729
type: UnificationXref
id: A8BEI6
db: uniprot

uniprot Q14957 70
type: UnificationXref
id: Q14957
db: uniprot

Calpain-6
type: ProteinReference
xref: uniprot G7NT58 132
xref: PTHR10183:SF381
organism: Macaca mulatta

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF88
xref: uniprot Q4QQV0 834
organism: Rattus norvegicus

PTHR11711:SF322
type: RelationshipXref
id: PTHR11711:SF322
db: PANTHER Family
relationship type: By Homology

PTHR11711:SF323
type: RelationshipXref
id: PTHR11711:SF323
db: PANTHER Family
relationship type: By Homology

Tubulin beta 3 class III
type: ProteinReference
xref: PTHR11588:SF43
xref: uniprot A0A2K6I1R2 720
organism: Pan troglodytes

Dynactin subunit 1
type: ProteinReference
xref: uniprot Q14203 1319
xref: PTHR18916:SF6
organism: Homo sapiens

Cytoplasmic dynein 1 heavy chain 1
type: ProteinReference
xref: PTHR10676:SF314
xref: uniprot Q14204 532
organism: Homo sapiens

CASP8 isoform 11
type: ProteinReference
xref: uniprot H2QJ86 1106
xref: PTHR10454:SF162
organism: Pan troglodytes

Quinone oxidoreductase
type: DnaReference
xref: PTHR44154:SF1
organism: Rattus norvegicus

Glutamate ionotropic receptor kainate type subunit 3
type: ProteinReference
xref: PTHR18966:SF174
xref: uniprot A0A3Q1M9Y0 622
organism: Bos taurus

uniprot Q5BEA4 1497
type: UnificationXref
id: Q5BEA4
db: uniprot

Cytoplasmic FMR1-interacting protein 1 homolog
type: ProteinReference
xref: uniprot Q90YM8 710
organism: Danio rerio

DISSOCIATION_LEFT__Complex__NMDA_receptor_PSD_95__Kainate_receptor_Htt__HAP1_Duo_-RIGHT__Complex__PSD_95_PolyQ_Htt_-_Duo-_NMDA_receptor-_Kainate_receptor-_Complex__Htt_HAP1_-_r79
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 1681
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 1680
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 1678
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 1677
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 1679
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 1676
left: Complex (NMDA receptor/PSD-95/ Kainate receptor/Htt/ HAP1/Duo)
interaction type: DISSOCIATION
right: Complex (Htt/HAP1)
right: NMDA receptor
right: Kainate receptor
right: Complex (PSD-95/PolyQ Htt)
right: Duo

uniprot P28148 1339
type: UnificationXref
id: P28148
db: uniprot

Complex (NMDA receptor/PSD-95/ Kainate receptor/Htt/ HAP1/Duo)
type: Complex
component stoichiometry: Kainate receptor s103 sa51 STOICHIOMETRY ID COMPLEX
component stoichiometry: HAP1 s110 sa53 STOICHIOMETRY ID COMPLEX
component stoichiometry: PSD 95 s101 sa50 STOICHIOMETRY ID COMPLEX
component stoichiometry: Duo s111 sa54 STOICHIOMETRY ID COMPLEX
component stoichiometry: Htt s109 sa52 STOICHIOMETRY ID COMPLEX
component stoichiometry: NMDA receptor s100 sa49 STOICHIOMETRY ID COMPLEX
component: HAP1
component: NMDA receptor
component: Htt
component: Duo
component: Kainate receptor
component: PSD-95
feature: COMPLEX BINDING FEATURE s215 a295 1612
feature: COMPLEX BINDING FEATURE s215 a295 1608
feature: COMPLEX BINDING FEATURE s215 a295 1602
feature: COMPLEX BINDING FEATURE s215 a295 1604
feature: COMPLEX BINDING FEATURE s215 a295 1606
feature: COMPLEX BINDING FEATURE s215 a295 1610
cellular location: synapse

uniprot Q13224 69
type: UnificationXref
id: Q13224
db: uniprot

PTHR11711:SF339
type: RelationshipXref
id: PTHR11711:SF339
db: PANTHER Family
relationship type: By Homology

uniprot H2Q322 1098
type: UnificationXref
id: H2Q322
db: uniprot

uniprot C4M7H7 1328
type: UnificationXref
id: C4M7H7
db: uniprot

PTHR11711:SF336
type: RelationshipXref
id: PTHR11711:SF336
db: PANTHER Family
relationship type: By Homology

PTHR11711:SF333
type: RelationshipXref
id: PTHR11711:SF333
db: PANTHER Family
relationship type: By Homology

PUMA
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

uniprot Q62645 75
type: UnificationXref
id: Q62645
db: uniprot

uniprot Q13002 650
type: UnificationXref
id: Q13002
db: uniprot

uniprot F7A567 1232
type: UnificationXref
id: F7A567
db: uniprot

STATE_TRANSITION_LEFT__beta_Tubulin-RIGHT__beta_Tubulin-_r71
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 1704
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 1703
left: beta-Tubulin
interaction type: STATE_TRANSITION
right: beta-Tubulin

Polyglutamine expanded mutant huntingtin
type: DnaRegionReference
member entity reference: Huntingtin
member entity reference: Uncharacterized protein
xref: G01532
comment: ENTITY_REFERENCE_NOTES= Long Name: Polyglutamine expanded mutant huntingtin Synonym: Synonym not specified Accession: G01532
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.GENE.GENE.PolyQ HTT
display name: PolyQ HTT

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 958

PTHR46143:SF1
type: RelationshipXref
id: PTHR46143:SF1
db: PANTHER Family
relationship type: By Homology

PTHR11711:SF340
type: RelationshipXref
id: PTHR11711:SF340
db: PANTHER Family
relationship type: By Homology

Hippi
type: Protein
entity reference: Hippi
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 433

uniprot P17325 1131
type: UnificationXref
id: P17325
db: uniprot

uniprot Q7QEC0 561
type: UnificationXref
id: Q7QEC0
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: uniprot P05412 1129
xref: PTHR11462:SF8
organism: Homo sapiens

p53
type: Protein
entity reference: p53
feature: ACTIVE 84
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F7C503 883
type: UnificationXref
id: F7C503
db: uniprot

uniprot F1PT97 1033
type: UnificationXref
id: F1PT97
db: uniprot

Caspase 6
type: ProteinReference
xref: P00809
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Caspase 6
comment: ENTITY_REFERENCE_NOTES= Long Name: Caspase 6 Synonym: Synonym not specified Accession: P00809
member entity reference: Caspase-6
member entity reference: Caspase 6

uniprot F7EXB7 495
type: UnificationXref
id: F7EXB7
db: uniprot

STATE_TRANSITION_LEFT__c_Jun-RIGHT__c_Jun-_r18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 1666
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 1665
left: c-Jun
interaction type: STATE_TRANSITION
right: c-Jun

ADP-ribosylation factor-like 4Ca
type: ProteinReference
xref: uniprot Q561U6 1495
xref: PTHR11711:SF119
organism: Danio rerio

uniprot E9FZ00 260
type: UnificationXref
id: E9FZ00
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9TVP1 220
organism: Physcomitrella patens

ncbitaxon 7955 33
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot P07829 307
type: UnificationXref
id: P07829
db: uniprot

Rab8 s89 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rab8
stoichiometric coefficient: 1.0

uniprot Q9HHE9 1361
type: UnificationXref
id: Q9HHE9
db: uniprot

MAPKK4
type: ProteinReference
xref: P00787
standard name: Mitogen activated protein kinase kinase 4
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.MAPKK4
comment: ENTITY_REFERENCE_NOTES= Long Name: Mitogen activated protein kinase kinase 4 Synonym: MEK4,MKK4 Accession: P00787
member entity reference: Uncharacterized protein
member entity reference: MAP2K4 isoform 3
member entity reference: Mitogen-activated protein kinase kinase 4A
member entity reference: Mitogen-activated protein kinase kinase 4
member entity reference: Dual specificity mitogen-activated protein kinase kinase 4
member entity reference: MAP2K4 protein

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

PTHR11711:SF357
type: RelationshipXref
id: PTHR11711:SF357
db: PANTHER Family
relationship type: By Homology

PTHR13808:SF1
type: RelationshipXref
id: PTHR13808:SF1
db: PANTHER Family
relationship type: By Homology

uniprot P37832 804
type: UnificationXref
id: P37832
db: uniprot

uniprot H2RB52 777
type: UnificationXref
id: H2RB52
db: uniprot

p53
type: Protein
entity reference: p53
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot E9FXV8 259
type: UnificationXref
id: E9FXV8
db: uniprot

Tubulin beta-2B chain
type: ProteinReference
xref: uniprot Q6B856 838
xref: PTHR11588:SF375
organism: Bos taurus

PTHR18916:SF70
type: RelationshipXref
id: PTHR18916:SF70
db: PANTHER Family
relationship type: By Homology

IP01149p
type: ProteinReference
xref: PTHR15138:SF14
xref: uniprot Q9VJP5 184
organism: Drosophila melanogaster

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r28
control type: ACTIVATION
controller: Membrane depolarization

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DMS9 1425
organism: Ornithorhynchus anatinus

uniprot P16858 945
type: UnificationXref
id: P16858
db: uniprot

uniprot Q48325 1347
type: UnificationXref
id: Q48325
db: uniprot

uniprot H3FK05 1239
type: UnificationXref
id: H3FK05
db: uniprot

uniprot F7ALP1 285
type: UnificationXref
id: F7ALP1
db: uniprot

Hip-1
type: Protein
entity reference: Hip-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s64 sa21 1651
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Actin
type: ProteinReference
xref: uniprot A2G1K5 195
xref: PTHR11937:SF387
organism: Trichomonas vaginalis

CREB-binding protein
type: ProteinReference
xref: uniprot Q6JHU9 1013
xref: PTHR13808:SF34
organism: Rattus norvegicus

Glutamate receptor ionotropic, NMDA 3B
type: ProteinReference
evidence: Evidence 49
evidence: Evidence 81
xref: PTHR18966:SF364
xref: uniprot Q91ZU9 83
organism: Mus musculus

Actin-2
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q8ILW9 407
organism: Plasmodium falciparum

Dynactin subunit 1
type: ProteinReference
xref: uniprot O08788 1315
xref: PTHR18916:SF6
organism: Mus musculus

uniprot P61213 1467
type: UnificationXref
id: P61213
db: uniprot

uniprot P61209 1464
type: UnificationXref
id: P61209
db: uniprot

uniprot F1PXS6 37
type: UnificationXref
id: F1PXS6
db: uniprot

uniprot E2RFV2 747
type: UnificationXref
id: E2RFV2
db: uniprot

Glutamate receptor, ionotropic, kainate 5
type: ProteinReference
xref: uniprot Q2HJD2 654
xref: PTHR18966:SF351
organism: Bos taurus

uniprot P97924 1535
type: UnificationXref
id: P97924
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 18

c Jun s29 a42 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Uncharacterized protein
type: ProteinReference
xref: uniprot E2R8R0 915
xref: PTHR10836:SF111
organism: Canis lupus familiaris

uniprot Q14204 532
type: UnificationXref
id: Q14204
db: uniprot

Actin
type: ProteinReference
xref: uniprot A2FA04 193
xref: PTHR11937:SF387
organism: Trichomonas vaginalis

AT13706p
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q9VAM8 1206
organism: Drosophila melanogaster

uniprot Q9FX54 991
type: UnificationXref
id: Q9FX54
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11711:SF139
xref: uniprot R4GGR6 1530
organism: Gallus gallus

Calpain-5
type: ProteinReference
xref: PTHR10183:SF402
xref: uniprot O15484 142
organism: Homo sapiens

uniprot Q0VCK5 892
type: UnificationXref
id: Q0VCK5
db: uniprot

uniprot Q9VZ20 588
type: UnificationXref
id: Q9VZ20
db: uniprot

PTHR24072:SF158
type: RelationshipXref
id: PTHR24072:SF158
db: PANTHER Family
relationship type: By Homology

Tubulin beta-3 chain
type: ProteinReference
xref: PTHR11588:SF395
xref: uniprot Q40665 828
organism: Oryza sativa

Uncharacterized protein
type: ProteinReference
xref: PTHR10676:SF310
xref: uniprot F1N5R7 471
organism: Bos taurus

PTHR11711:SF316
type: RelationshipXref
id: PTHR11711:SF316
db: PANTHER Family
relationship type: By Homology

uniprot Q6P640 392
type: UnificationXref
id: Q6P640
db: uniprot

Calpain-10
type: ProteinReference
xref: uniprot Q9HC96 174
xref: PTHR10183:SF30
organism: Homo sapiens

PTHR24072:SF169
type: RelationshipXref
id: PTHR24072:SF169
db: PANTHER Family
relationship type: By Homology

Protein fragment
type: Protein
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot H2QM89 505
type: UnificationXref
id: H2QM89
db: uniprot

SIN3 transcription regulator family member A
type: ProteinReference
xref: PTHR12346:SF2
xref: uniprot F1MTR3 89
organism: Bos taurus

Calpain 3
type: ProteinReference
xref: PTHR10183:SF329
xref: uniprot E2R8T7 122
organism: Canis lupus familiaris

uniprot P20359 320
type: UnificationXref
id: P20359
db: uniprot

PTHR10676:SF339
type: RelationshipXref
id: PTHR10676:SF339
db: PANTHER Family
relationship type: By Homology

PTHR24072:SF136
type: RelationshipXref
id: PTHR24072:SF136
db: PANTHER Family
relationship type: By Homology

ADP-ribosylation factor B1C
type: ProteinReference
xref: PTHR11711:SF371
xref: uniprot Q9M9N1 1526
organism: Arabidopsis thaliana

Actin-12
type: ProteinReference
xref: PTHR11937:SF434
xref: uniprot P53497 330
organism: Arabidopsis thaliana

uniprot P09124 938
type: UnificationXref
id: P09124
db: uniprot

uniprot F1P7Y7 1020
type: UnificationXref
id: F1P7Y7
db: uniprot

Actin-4
type: ProteinReference
xref: uniprot P53494 329
xref: PTHR11937:SF438
organism: Arabidopsis thaliana

uniprot P48554 1254
type: UnificationXref
id: P48554
db: uniprot

Actin-7
type: ProteinReference
xref: PTHR11937:SF483
xref: uniprot P53492 328
organism: Arabidopsis thaliana

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF37
xref: uniprot P53489 327
organism: Caenorhabditis elegans

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__MLK_2-RIGHT__MLK_2-_r13
control type: ACTIVATION
controller: Ca2+

uniprot P04973 662
type: UnificationXref
id: P04973
db: uniprot

uniprot A0A1D5NV94 876
type: UnificationXref
id: A0A1D5NV94
db: uniprot

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 985

uniprot Q8VHE6 569
type: UnificationXref
id: Q8VHE6
db: uniprot

PTHR10676:SF343
type: RelationshipXref
id: PTHR10676:SF343
db: PANTHER Family
relationship type: By Homology

uniprot Q96L46 169
type: UnificationXref
id: Q96L46
db: uniprot

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF37
xref: uniprot P53488 326
organism: Gallus gallus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Caspase_3-RIGHT__Caspase_3-_r1
controller: PolyQ Htt

uniprot Q38D64 1490
type: UnificationXref
id: Q38D64
db: uniprot

uniprot A8XGW3 1210
type: UnificationXref
id: A8XGW3
db: uniprot

PTHR10676:SF344
type: RelationshipXref
id: PTHR10676:SF344
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r14 1685
type: Stoichiometry
physical entity: MAPKK4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 1684
type: Stoichiometry
physical entity: MAPKK4
stoichiometric coefficient: 1.0

p53
type: ProteinReference
xref: P00797
standard name: Tumor protein p53
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: P53 tumor suppressor phosphoprotein Synonym: TP53 Accession: P00797
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.p53
member entity reference: Cytoplasmic FMR1-interacting protein
member entity reference: Cellular tumor antigen p53
member entity reference: Tumor protein 63 (p63)
member entity reference: Cytoplasmic FMR1-interacting protein 1 homolog
member entity reference: Tumor protein 63
member entity reference: Cytoplasmic FMR1-interacting protein 2
member entity reference: Cytoplasmic FMR1-interacting protein 1
member entity reference: Protein pirA
member entity reference: Tumor protein p73
member entity reference: Cytoplasmic FMR1-interacting protein homolog
member entity reference: AGAP004319-PA

Actin, cytoplasmic type 5
type: ProteinReference
xref: uniprot P53478 325
xref: PTHR11937:SF168
organism: Gallus gallus

ncbitaxon 39947 198
type: UnificationXref
id: 39947
db: ncbitaxon

NAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000303 1326

uniprot A0A2K6I1R2 720
type: UnificationXref
id: A0A2K6I1R2
db: uniprot

Tubulin beta-4 chain
type: ProteinReference
xref: uniprot P41937 806
xref: PTHR11588:SF279
organism: Caenorhabditis elegans

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 426

Tubulin beta-6 chain
type: ProteinReference
xref: uniprot Q2HJ81 821
xref: PTHR11588:SF88
organism: Bos taurus

uniprot Q6IRU5 666
type: UnificationXref
id: Q6IRU5
db: uniprot

Fos protein
type: Protein
entity reference: Fos protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s114 sa5 1569
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot Q5R1X3 383
type: UnificationXref
id: Q5R1X3
db: uniprot

uniprot F7C587 1105
type: UnificationXref
id: F7C587
db: uniprot

uniprot O35920 145
type: UnificationXref
id: O35920
db: uniprot

uniprot C3XYC4 237
type: UnificationXref
id: C3XYC4
db: uniprot

PTHR10676:SF358
type: RelationshipXref
id: PTHR10676:SF358
db: PANTHER Family
relationship type: By Homology

PTHR10676:SF352
type: RelationshipXref
id: PTHR10676:SF352
db: PANTHER Family
relationship type: By Homology

Actin, cytoskeletal 3A
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P53474 324
organism: Strongylocentrotus purpuratus

PARTICIPANT STOICHIOMETRY r13 1689
type: Stoichiometry
physical entity: MLK-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 1688
type: Stoichiometry
physical entity: MLK-2
stoichiometric coefficient: 1.0

Actin
type: ProteinReference
xref: uniprot B3RKR4 228
xref: PTHR11937:SF387
organism: Trichoplax adhaerens

ADP-ribosylation factor D1A
type: ProteinReference
xref: uniprot F4HXI5 1410
xref: PTHR11711:SF339
organism: Arabidopsis thaliana

PTHR43677:SF4
type: RelationshipXref
id: PTHR43677:SF4
db: PANTHER Family
relationship type: By Homology

ADP-ribosylation factor D1B
type: ProteinReference
xref: uniprot F4HXI4 1409
xref: PTHR11711:SF339
organism: Arabidopsis thaliana

uniprot Q5IS78 599
type: UnificationXref
id: Q5IS78
db: uniprot

PACSIN-1
type: ProteinReference
xref: P00802
standard name: Protein kinase C and casein kinase substrate in neurons 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.PACSIN-1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein kinase C and casein kinase substrate in neurons 1
member entity reference: Protein kinase C and casein kinase substrate in neurons protein 1

uniprot C3YC50 245
type: UnificationXref
id: C3YC50
db: uniprot

uniprot P0DM41 310
type: UnificationXref
id: P0DM41
db: uniprot

Os08g0248900 protein
type: ProteinReference
xref: uniprot Q6YW27 1509
xref: PTHR11711:SF41
organism: Oryza sativa

uniprot A9TZ58 223
type: UnificationXref
id: A9TZ58
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CLW1 1137
organism: Monodelphis domestica

uniprot Q6JHU9 1013
type: UnificationXref
id: Q6JHU9
db: uniprot

STATE_TRANSITION_LEFT__Calpain-RIGHT__Calpain-_r23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1736
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1737
left: Calpain
interaction type: STATE_TRANSITION
right: Calpain

uniprot H2QI59 1314
type: UnificationXref
id: H2QI59
db: uniprot

Tubulin beta-3 chain
type: ProteinReference
xref: PTHR11588:SF43
xref: uniprot Q4QRB4 835
organism: Rattus norvegicus

Dynein light chain 1, cytoplasmic
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot Q02647 529
organism: Saccharomyces cerevisiae

PTHR10676:SF361
type: RelationshipXref
id: PTHR10676:SF361
db: PANTHER Family
relationship type: By Homology

ncbitaxon 3702 101
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot E1BX21 88
type: UnificationXref
id: E1BX21
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3YKS6 246
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: PTHR10454:SF162
xref: uniprot F7C587 1105
organism: Macaca mulatta

uniprot D4AA88 675
type: UnificationXref
id: D4AA88
db: uniprot

PTHR10676:SF374
type: RelationshipXref
id: PTHR10676:SF374
db: PANTHER Family
relationship type: By Homology

uniprot Q8I4X0 405
type: UnificationXref
id: Q8I4X0
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__PolyQ_Htt-_Htt-RIGHT__Complex__Htt_PolyQ_Htt_-_r4
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1672
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1671
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1673
left: Htt
left: PolyQ Htt
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Htt/PolyQ Htt)

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot A8HP84 906
organism: Chlamydomonas reinhardtii

Synaptojanin
type: ProteinReference
xref: P00804
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Synaptojanin
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Synaptojanin-1
member entity reference: Protein CBR-UNC-26
member entity reference: Synaptojanin

Rac-like GTP-binding protein 7
type: ProteinReference
xref: uniprot Q6Z7L8 1289
organism: Oryza sativa

uniprot P17329 946
type: UnificationXref
id: P17329
db: uniprot

Actin, beta-like 2
type: ProteinReference
xref: uniprot D3ZRN3 253
xref: PTHR11937:SF168
organism: Rattus norvegicus

uniprot P60706 333
type: UnificationXref
id: P60706
db: uniprot

Actin, putative (Fragment)
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot B7PBG2 232
organism: Ixodes scapularis

PTHR11711:SF364
type: RelationshipXref
id: PTHR11711:SF364
db: PANTHER Family
relationship type: By Homology

uniprot Q8TE73 568
type: UnificationXref
id: Q8TE73
db: uniprot

uniprot Q9N4I0 411
type: UnificationXref
id: Q9N4I0
db: uniprot

uniprot Q380U3 1274
type: UnificationXref
id: Q380U3
db: uniprot

Complex (PolyQ Htt/GAPDH)
type: Complex
component stoichiometry: GAPDH s62 sa19 STOICHIOMETRY ID COMPLEX
component stoichiometry: PolyQ Htt s61 sa18 STOICHIOMETRY ID COMPLEX
component: PolyQ Htt
component: GAPDH
feature: COMPLEX BINDING FEATURE s95 a121 1598
feature: COMPLEX BINDING FEATURE s95 a121 1600
cellular location: nucleus

Uncharacterized protein
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot F6PNX7 1412
organism: Monodelphis domestica

Dynactin subunit 1
type: ProteinReference
xref: PTHR18916:SF6
xref: uniprot P28023 1317
organism: Rattus norvegicus

Cytochrome c1, heme protein, mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot D6XKS6 1187
organism: Trypanosoma brucei

PTHR10676:SF387
type: RelationshipXref
id: PTHR10676:SF387
db: PANTHER Family
relationship type: By Homology

PTHR24072:SF105
type: RelationshipXref
id: PTHR24072:SF105
db: PANTHER Family
relationship type: By Homology

uniprot Q5ADM7 970
type: UnificationXref
id: Q5ADM7
db: uniprot

Hippi s66 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Hippi
stoichiometric coefficient: 1.0

PTHR11711:SF371
type: RelationshipXref
id: PTHR11711:SF371
db: PANTHER Family
relationship type: By Homology

ADP-ribosylation factor 2-B
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot P0DH91 1444
organism: Arabidopsis thaliana

PTHR11711:SF370
type: RelationshipXref
id: PTHR11711:SF370
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot C3YC50 245
xref: PTHR11937:SF446
organism: Branchiostoma floridae

Male fertility factor kl3
type: ProteinReference
xref: uniprot A8Y5B7 451
xref: PTHR10676:SF318
organism: Drosophila melanogaster

uniprot Q91YD9 1072
type: UnificationXref
id: Q91YD9
db: uniprot

Candida albicans
type: BioSource
xref: ncbitaxon 237561 971

PTHR11711:SF379
type: RelationshipXref
id: PTHR11711:SF379
db: PANTHER Family
relationship type: By Homology

PTHR11711:SF372
type: RelationshipXref
id: PTHR11711:SF372
db: PANTHER Family
relationship type: By Homology

uniprot P07828 305
type: UnificationXref
id: P07828
db: uniprot

PTHR11711:SF375
type: RelationshipXref
id: PTHR11711:SF375
db: PANTHER Family
relationship type: By Homology

uniprot Q9SAJ6 997
type: UnificationXref
id: Q9SAJ6
db: uniprot

uniprot P09652 793
type: UnificationXref
id: P09652
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2RJX4 1156
xref: PTHR24356:SF171
organism: Canis lupus familiaris

uniprot P53494 329
type: UnificationXref
id: P53494
db: uniprot

ADP-ribosylation factor 4
type: ProteinReference
xref: uniprot P61751 1470
xref: PTHR11711:SF110
organism: Rattus norvegicus

ADP-ribosylation factor 4
type: ProteinReference
xref: uniprot P61750 1469
xref: PTHR11711:SF110
organism: Mus musculus

synapse
type: CellularLocationVocabulary
xref: GO GO:0045202 5

PTHR11711:SF382
type: RelationshipXref
id: PTHR11711:SF382
db: PANTHER Family
relationship type: By Homology

PTHR11711:SF381
type: RelationshipXref
id: PTHR11711:SF381
db: PANTHER Family
relationship type: By Homology

PTHR11711:SF385
type: RelationshipXref
id: PTHR11711:SF385
db: PANTHER Family
relationship type: By Homology

PTHR11711:SF383
type: RelationshipXref
id: PTHR11711:SF383
db: PANTHER Family
relationship type: By Homology

ADP ribosylation factor 4
type: ProteinReference
xref: uniprot J9P5N6 1441
xref: PTHR11711:SF110
organism: Canis lupus familiaris

uniprot Q18853 1199
type: UnificationXref
id: Q18853
db: uniprot

MLK 2 s39 a53 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

PTHR11588:SF247
type: RelationshipXref
id: PTHR11588:SF247
db: PANTHER Family
relationship type: By Homology

uniprot F6V2X8 1419
type: UnificationXref
id: F6V2X8
db: uniprot

ADP-ribosylation factor B1B
type: ProteinReference
xref: PTHR11711:SF382
xref: uniprot Q9LFJ7 1523
organism: Arabidopsis thaliana

Synaptojanin s78 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Synaptojanin
stoichiometric coefficient: 1.0

uniprot P00789 148
type: UnificationXref
id: P00789
db: uniprot

ADP-ribosylation factor 1
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot Q6NT85 1503
organism: Xenopus tropicalis

Dynein heavy chain at 89D, isoform B
type: ProteinReference
xref: uniprot Q9VAV5 585
xref: PTHR10676:SF343
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A2K3D1N8 443
xref: PTHR10676:SF343
organism: Chlamydomonas reinhardtii

AP-2 complex subunit alpha
type: ProteinReference
xref: uniprot Q1K5B2 893
xref: PTHR22780:SF4
organism: Neurospora crassa

uniprot O67161 928
type: UnificationXref
id: O67161
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot H2KNE6 293
organism: Phaeosphaeria nodorum

PTHR11711:SF390
type: RelationshipXref
id: PTHR11711:SF390
db: PANTHER Family
relationship type: By Homology

PTHR11711:SF396
type: RelationshipXref
id: PTHR11711:SF396
db: PANTHER Family
relationship type: By Homology

Putative cytochrome c1, heme protein,mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q4QIT8 1200
organism: Leishmania major

Paired amphipathic helix protein Sin3-like 4
type: ProteinReference
xref: uniprot O04539 100
xref: PTHR12346:SF0
organism: Arabidopsis thaliana

uniprot W4XHC0 868
type: UnificationXref
id: W4XHC0
db: uniprot

uniprot P61208 1463
type: UnificationXref
id: P61208
db: uniprot

PTHR18916:SF6
type: RelationshipXref
id: PTHR18916:SF6
db: PANTHER Family
relationship type: By Homology

uniprot Q8VHN2 82
type: UnificationXref
id: Q8VHN2
db: uniprot

uniprot P63167 526
type: UnificationXref
id: P63167
db: uniprot

uniprot H2QZZ2 52
type: UnificationXref
id: H2QZZ2
db: uniprot

uniprot P61211 1465
type: UnificationXref
id: P61211
db: uniprot

Dynein cytoplasmic 1 light intermediate chain 2
type: ProteinReference
xref: PTHR12688:SF1
xref: uniprot F1P6V8 475
organism: Canis lupus familiaris

PTHR22780:SF33
type: RelationshipXref
id: PTHR22780:SF33
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot H3E6Q9 1437
xref: PTHR11711:SF381
organism: Pristionchus pacificus

PTHR22780:SF30
type: RelationshipXref
id: PTHR22780:SF30
db: PANTHER Family
relationship type: By Homology

Actin, alpha skeletal muscle
type: ProteinReference
xref: PTHR11937:SF193
xref: uniprot P68134 356
organism: Mus musculus

Actin, alpha skeletal muscle
type: ProteinReference
xref: PTHR11937:SF193
xref: uniprot P68133 355
organism: Homo sapiens

Actin, alpha skeletal muscle
type: ProteinReference
xref: PTHR11937:SF193
xref: uniprot P68136 357
organism: Rattus norvegicus

Actin, alpha skeletal muscle
type: ProteinReference
xref: PTHR11937:SF193
xref: uniprot P68138 358
organism: Bos taurus

Brain-derived neurotrophic factor
type: DnaReference
xref: PTHR11589:SF3
organism: Bos taurus

AGAP011730-PA (Fragment)
type: ProteinReference
xref: uniprot Q7PZ49 1514
xref: PTHR11711:SF41
organism: Anopheles gambiae

Actin, alpha skeletal muscle
type: ProteinReference
xref: PTHR11937:SF193
xref: uniprot P68139 359
organism: Gallus gallus

PTHR22780:SF38
type: RelationshipXref
id: PTHR22780:SF38
db: PANTHER Family
relationship type: By Homology

ADP-ribosylation factor
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot A8BSW7 1381
organism: Giardia intestinalis

Os05g0301700 protein
type: ProteinReference
xref: PTHR10266:SF11
xref: uniprot Q0DJC3 1198
organism: Oryza sativa

Calpain-3
type: ProteinReference
xref: uniprot P20807 154
xref: PTHR10183:SF329
organism: Homo sapiens

uniprot F1ME41 469
type: UnificationXref
id: F1ME41
db: uniprot

uniprot K7CKA1 138
type: UnificationXref
id: K7CKA1
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot F7FFR0 771
xref: PTHR11588:SF100
organism: Ornithorhynchus anatinus

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF37
xref: uniprot I2CYF0 300
organism: Macaca mulatta

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot P63001 1260
organism: Mus musculus

Nuclear receptor corepressor 2
type: ProteinReference
xref: PTHR13992:SF21
xref: uniprot F1PQQ7 1368
organism: Canis lupus familiaris

uniprot F6WN64 1037
type: UnificationXref
id: F6WN64
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot P63000 1259
organism: Homo sapiens

uniprot F6V4X2 1420
type: UnificationXref
id: F6V4X2
db: uniprot

Dynein light chain
type: ProteinReference
xref: uniprot Q5F412 544
xref: PTHR11886:SF62
organism: Gallus gallus

Giardia intestinalis
type: BioSource
xref: ncbitaxon 184922 209

Dynein heavy chain, cytoplasmic
type: ProteinReference
xref: PTHR10676:SF314
xref: uniprot P36022 521
organism: Saccharomyces cerevisiae

uniprot P63268 348
type: UnificationXref
id: P63268
db: uniprot

NMDA receptor
type: ProteinReference
xref: P00778
standard name: N-methyl-d-aspartate receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.ION_CHANNEL.NMDA_br_receptor
comment: ENTITY_REFERENCE_NOTES= Long Name: N-methyl-d-aspartate receptor Synonym: Synonym not specified Accession: P00778
member entity reference: Glutamate receptor ionotropic, NMDA 2C
member entity reference: Glutamate ionotropic receptor NMDA type subunit 3A
member entity reference: Uncharacterized protein
member entity reference: N-methyl D-aspartate receptor subtype 2B
member entity reference: Glutamate receptor ionotropic, NMDA3A
member entity reference: Glutamate receptor ionotropic, NMDA 1
member entity reference: AGAP001478-PA
member entity reference: Glutamate receptor ionotropic, NMDA 2D
member entity reference: Glutamate receptor ionotropic, NMDA 2A
member entity reference: Glutamate receptor ionotropic, NMDA 2B
member entity reference: Glutamate receptor ionotropic, NMDA 3B
member entity reference: Glutamate ionotropic receptor NMDA type subunit 2A
member entity reference: NMDA class glutamate Receptor
member entity reference: Glutamate receptor, ionotropic, N-methyl D-aspartate 1b
member entity reference: Glutamate receptor ionotropic, NMDA 3A
member entity reference: GRIN2B isoform 3
member entity reference: Glutamate ionotropic receptor NMDA type subunit 1
member entity reference: N-methyl-D-aspartate receptor type 1 subunit
member entity reference: Glutamate [NMDA] receptor subunit 1
member entity reference: Glutamate [NMDA] receptor subunit zeta-1 isoform NR1-3
member entity reference: Glutamate receptor, ionotropic, N-methyl D-aspartate 1a
member entity reference: Protein CBR-NMR-1

Huntington disease
type: Pathway
pathway component: STATE_TRANSITION_LEFT__SEK_1-RIGHT__SEK_1-_r16
pathway component: STATE_TRANSITION_LEFT__MLK_2-RIGHT__MLK_2-_r13
pathway component: STATE_TRANSITION_LEFT__PolyQ_Htt-RIGHT__PolyQ_Htt-_r20
pathway component: STATE_TRANSITION_LEFT__PolyQ_Htt-RIGHT__PolyQ_Htt-_r38
pathway component: HETERODIMER_ASSOCIATION_LEFT__PolyQ_Htt-_GAPDH-RIGHT__PolyQ_Htt-_r56
pathway component: PHYSICAL_STIMULATION
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Hip_12_Hip_1_-_alpha_Adaptin-_Clathrin-_Actin-_Htt-RIGHT__Complex__Hip_12_Hip_1__Clathrin_alpha_Adaptin__Htt_Actin_-_r81
pathway component: HETERODIMER_ASSOCIATION_LEFT__Hip_1-_Htt-RIGHT__Complex__Htt_Hip_1_-_r80
pathway component: MODULATION
pathway component: TRANSCRIPTION_LEFT__Bax-RIGHT__Bax-_re66
pathway component: TRANSCRIPTION_LEFT__Proline_oxidase-RIGHT__Proline_oxidase-_re68
pathway component: TRANSCRIPTION_LEFT__BDNF-RIGHT__BDNF-_re74
pathway component: STATE_TRANSITION_LEFT__MAPKK7-RIGHT__MAPKK7-_r15
pathway component: STATE_TRANSITION_LEFT__Truncated_Htt-RIGHT__Truncated_Htt-_r46
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__NMDA_receptor_PSD_95__Kainate_receptor_Htt__HAP1_Duo_-_PolyQ_Htt-RIGHT__Complex__PSD_95_PolyQ_Htt_-_r77
pathway component: STATE_TRANSITION_LEFT__Arp2_3_complex-RIGHT__Arp2_3_complex-_r66
pathway component: TRANSPORT_LEFT__Complex__PolyQ_Htt_GAPDH_-RIGHT__Complex__PolyQ_Htt_GAPDH_-_r53
pathway component: TRUNCATION_LEFT__Htt-RIGHT__Protein_fragment-_Truncated_Htt-_r22
pathway component: STATE_TRANSITION_LEFT__PolyQ_Htt-RIGHT__PolyQ_Htt-_r3
pathway component: STATE_TRANSITION_LEFT__c_Jun-RIGHT__c_Jun-_r18
pathway component: HETERODIMER_ASSOCIATION_LEFT__PolyQ_Htt-_Htt-RIGHT__Complex__Htt_PolyQ_Htt_-_r4
pathway component: STATE_TRANSITION_LEFT__Complex__Rac_GDP_-_GTP-RIGHT__Complex__Rac_GTP_-_GDP-_r75
pathway component: STATE_TRANSITION_LEFT__MLK_2-RIGHT__MLK_2-_r26
pathway component: DISSOCIATION_LEFT__Complex__NMDA_receptor_PSD_95__Kainate_receptor_Htt__HAP1_Duo_-RIGHT__Complex__PSD_95_PolyQ_Htt_-_Duo-_NMDA_receptor-_Kainate_receptor-_Complex__Htt_HAP1_-_r79
pathway component: TRANSCRIPTION_LEFT__PIG3-RIGHT__PIG3-_re70
pathway component: HETERODIMER_ASSOCIATION_LEFT__Fos_protein-_c_Jun-RIGHT__Complex__Fos_protein_c_Jun_-_r33
pathway component: TRANSLATION_LEFT__BDNF-RIGHT__BDNF-_re75
pathway component: STATE_TRANSITION_LEFT__Apaf_1-RIGHT__Apaf_1-_r30
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r28
pathway component: STATE_TRANSITION_LEFT__Caspase_3-RIGHT__Caspase_3-_r1
pathway component: TRANSLATION_LEFT__HTT-RIGHT__Htt-_re77
pathway component: STATE_TRANSITION_LEFT__Actin-RIGHT__Actin-_r67
pathway component: TRANSCRIPTION_LEFT__PolyQ_HTT-RIGHT__PolyQ_HTT-_re79
pathway component: HETERODIMER_ASSOCIATION_LEFT__Hip_1-_Hippi-RIGHT__Complex__Hip_1_Hippi_-_r58
pathway component: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_r39
pathway component: TRANSPORT_LEFT__Cytochrome_c-RIGHT__Cytochrome_c-_r29
pathway component: STATE_TRANSITION_LEFT__MAPKK4-RIGHT__MAPKK4-_r14
pathway component: HETERODIMER_ASSOCIATION_LEFT__CBP-_PolyQ_Htt-RIGHT__Complex__CBP_PolyQ_Htt_-_r37
pathway component: TRANSCRIPTION_LEFT__PUMA-RIGHT__PUMA-_re69
pathway component: TRUNCATION_LEFT__Pro_caspase_8-RIGHT__Protein_fragment-_Caspase_8-_r59
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r12
pathway component: STATE_TRANSITION_LEFT__beta_Tubulin-RIGHT__beta_Tubulin-_r71
pathway component: TRANSCRIPTION_LEFT__HTT-RIGHT__HTT-_re76
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r11
pathway component: STATE_TRANSITION_LEFT__Calpain-RIGHT__Calpain-_r23
pathway component: TRANSLATION_LEFT__PolyQ_HTT-RIGHT__PolyQ_Htt-_re78
pathway component: STATE_TRANSITION_LEFT__JNK_2-RIGHT__JNK_2-_r17
pathway component: DISSOCIATION_LEFT__Complex__PolyQ_Htt_GAPDH_-RIGHT__GAPDH-_PolyQ_Htt-_r55
xref: PANTHER Pathway P00029 1
comment: MODEL_NOTES=Panther Pathway: P00029 Huntington's disease is associated with a mutant polyglutamine expansion in the huntingtin gene. Wild-type huntingtin protein is normally involved in vesicle endocytosis, regulation of calcium channels via the PSD-95 complex, and inhibition of apoptosis via BDNF. Mutant, polyglutamine expanded huntingtin may lose these functions, as well as gain toxicity via stimulation of apoptosis, regulation of gene transcription via p53, and abnormal calcium-mediated signal transduction pathways. Medline=11724916 Medline=12569151 Medline=12932731 Medline=14526190 PMID: 11724916 PMID: 12569151 PMID: 12932731 PMID: 14526190

uniprot P0DM42 311
type: UnificationXref
id: P0DM42
db: uniprot

uniprot P40994 1456
type: UnificationXref
id: P40994
db: uniprot

Tubulin beta-1 chain
type: ProteinReference
xref: uniprot P12411 797
xref: PTHR11588:SF116
organism: Arabidopsis thaliana

Arfaptin-2
type: Protein
entity reference: Arfaptin-2
feature: COMPLEX PARTICIPANT BINDING FEATURE s116 sa57 1577
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Protein CBR-ARL-8
type: ProteinReference
xref: uniprot A8Y0A3 1386
xref: PTHR45732:SF7
organism: Caenorhabditis briggsae

uniprot P53501 331
type: UnificationXref
id: P53501
db: uniprot

ADP-ribosylation factor-like protein 4D
type: ProteinReference
xref: PTHR11711:SF137
xref: uniprot P49703 1457
organism: Homo sapiens

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot A0A2I3T9Y4 1153
organism: Pan troglodytes

Tubulin beta-4B chain
type: ProteinReference
xref: uniprot Q6P9T8 844
xref: PTHR11588:SF247
organism: Rattus norvegicus

ADP-ribosylation factor-like protein 4D
type: ProteinReference
xref: PTHR11711:SF137
xref: uniprot Q0VC18 1484
organism: Bos taurus

Protein CBR-UNC-26
type: ProteinReference
xref: uniprot A8WQT0 1182
organism: Caenorhabditis briggsae

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XUU0 281
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF325
xref: uniprot F7GY91 1235
organism: Macaca mulatta

uniprot P84077 1474
type: UnificationXref
id: P84077
db: uniprot

N-methyl D-aspartate receptor subtype 2B
type: ProteinReference
evidence: Evidence 25
evidence: Evidence 22
xref: uniprot F6T8S6 40
xref: PTHR18966:SF382
organism: Macaca mulatta

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot F1MKA9 678
organism: Bos taurus

ADP-ribosylation factor 2
type: ProteinReference
xref: PTHR11711:SF110
xref: uniprot Q7PQY7 1513
organism: Anopheles gambiae

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot O77628 425
organism: Bos taurus

Calpain 1
type: ProteinReference
xref: uniprot F6UZV8 128
xref: PTHR10183:SF284
organism: Canis lupus familiaris

Htt s109 sa52 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Htt
stoichiometric coefficient: 1.0

Transcription factor AP-1
type: ProteinReference
xref: uniprot O77627 1128
xref: PTHR11462:SF8
organism: Bos taurus

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF404
xref: uniprot O17921 784
organism: Caenorhabditis elegans

uniprot P17427 888
type: UnificationXref
id: P17427
db: uniprot

uniprot A9V847 1389
type: UnificationXref
id: A9V847
db: uniprot

Glutamate receptor ionotropic, kainate 1
type: ProteinReference
xref: PTHR18966:SF36
xref: uniprot P22756 644
organism: Rattus norvegicus

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P56424 701
xref: PTHR11447:SF6
organism: Macaca mulatta

TNF alpha induced protein 8
type: ProteinReference
xref: uniprot A0A2I3TBB9 1134
organism: Pan troglodytes

PolyQ Htt s54 a73 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P02572 303
type: UnificationXref
id: P02572
db: uniprot

uniprot A0A1D5RK09 1095
type: UnificationXref
id: A0A1D5RK09
db: uniprot

uniprot Q9UR05 584
type: UnificationXref
id: Q9UR05
db: uniprot

Cytoplasmic dynein 1 light intermediate chain 2
type: ProteinReference
xref: uniprot O43237 514
xref: PTHR12688:SF1
organism: Homo sapiens

SIN3 transcription regulator family member B
type: ProteinReference
xref: PTHR12346:SF1
xref: uniprot H2Q9U2 98
organism: Pan troglodytes

uniprot E2RK00 465
type: UnificationXref
id: E2RK00
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23202:SF39
xref: uniprot E1BTH9 1067
organism: Gallus gallus

uniprot P78711 360
type: UnificationXref
id: P78711
db: uniprot

Actin-related protein 2/3 complex subunit 5-like protein
type: ProteinReference
xref: uniprot Q9BPX5 1061
xref: PTHR12644:SF2
organism: Homo sapiens

uniprot F7F082 770
type: UnificationXref
id: F7F082
db: uniprot

Caspase-3
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot O93417 1148
organism: Gallus gallus

Actin
type: ProteinReference
xref: uniprot Q9U1E8 412
xref: PTHR11937:SF387
organism: Leishmania major

uniprot A7S0V7 204
type: UnificationXref
id: A7S0V7
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot Q7KQL5 854
xref: PTHR11588:SF9
organism: Plasmodium falciparum

ADP-ribosylation factor 1
type: ProteinReference
xref: uniprot Q7KQL3 1512
xref: PTHR11711:SF30
organism: Plasmodium falciparum

Rac-like GTP-binding protein 6
type: ProteinReference
xref: uniprot Q6ZHA3 1290
organism: Oryza sativa

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 51

Rac-like GTP-binding protein ARAC7
type: ProteinReference
xref: uniprot O82480 1241
organism: Arabidopsis thaliana

uniprot F1PDQ4 681
type: UnificationXref
id: F1PDQ4
db: uniprot

uniprot O43026 927
type: UnificationXref
id: O43026
db: uniprot

ADP-ribosylation factor 1
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot B3RQZ1 1392
organism: Trichoplax adhaerens

uniprot O75146 1091
type: UnificationXref
id: O75146
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6V2X8 1419
xref: PTHR11711:SF323
organism: Monodelphis domestica

Calpain 7
type: ProteinReference
xref: PTHR46143:SF1
xref: uniprot Q499T5 161
organism: Rattus norvegicus

eco ECO:0000245 1306
type: UnificationXref
id: ECO:0000245
db: eco

Uncharacterized protein
type: ProteinReference
xref: PTHR11711:SF379
xref: uniprot F7FYA6 1426
organism: Monodelphis domestica

Sp1 transcription factor
type: ProteinReference
xref: uniprot A0A2I3RCN7 1119
organism: Pan troglodytes

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot A9RY37 734
organism: Physcomitrella patens

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NXP6 1103
xref: PTHR10454:SF162
organism: Gallus gallus

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot Q29537 704
organism: Canis lupus familiaris

uniprot Q6DHS1 387
type: UnificationXref
id: Q6DHS1
db: uniprot

uniprot Q9RUP1 995
type: UnificationXref
id: Q9RUP1
db: uniprot

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot B7PJZ9 454
organism: Ixodes scapularis

PTHR10183:SF30
type: RelationshipXref
id: PTHR10183:SF30
db: PANTHER Family
relationship type: By Homology

ncbitaxon 7165 79
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot A0A2I3RCN7 1119
type: UnificationXref
id: A0A2I3RCN7
db: uniprot

BDNF
type: DnaRegion
entity reference: Brain-derived neurotrophic factor
cellular location: synapse
comment: SPECIES_TYPE=GENE

uniprot Q9I9H8 1115
type: UnificationXref
id: Q9I9H8
db: uniprot

Oxidative stress
type: Pathway

Complex (Rab8/FIP-2/ Htt)
type: Complex
component stoichiometry: FIP 2 s90 sa43 STOICHIOMETRY ID COMPLEX
component stoichiometry: Htt s91 sa44 STOICHIOMETRY ID COMPLEX
component stoichiometry: Rab8 s89 sa42 STOICHIOMETRY ID COMPLEX
component: FIP-2
component: Rab8
component: Htt
feature: COMPLEX BINDING FEATURE s176 a240 1632
feature: COMPLEX BINDING FEATURE s176 a240 1636
feature: COMPLEX BINDING FEATURE s176 a240 1634
cellular location: synapse

uniprot P09653 794
type: UnificationXref
id: P09653
db: uniprot

Quinone oxidoreductase
type: DnaReference
xref: PTHR48106:SF13
organism: Neurospora crassa

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__PIG3-RIGHT__PIG3-_re70
control type: ACTIVATION
controller: p53

ADP-ribosylation factor 6
type: ProteinReference
xref: PTHR11711:SF322
xref: uniprot Q9Y7Z2 1529
organism: Schizosaccharomyces pombe

uniprot F6YLB3 42
type: UnificationXref
id: F6YLB3
db: uniprot

Protein CBR-TRA-3
type: ProteinReference
xref: PTHR10183:SF379
xref: uniprot A8Y0F3 117
organism: Caenorhabditis briggsae

uniprot Q1K5B2 893
type: UnificationXref
id: Q1K5B2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Actin-RIGHT__Actin-_r67
controller: Arp2/3 complex

uniprot Q95106 601
type: UnificationXref
id: Q95106
db: uniprot

PTHR48106:SF8
type: RelationshipXref
id: PTHR48106:SF8
db: PANTHER Family
relationship type: By Homology

uniprot Q38E94 369
type: UnificationXref
id: Q38E94
db: uniprot

TRANSCRIPTION_LEFT__PolyQ_HTT-RIGHT__PolyQ_HTT-_re79
type: TemplateReaction
product: PolyQ HTT
xref: TRANSCRIPTION
participant: PolyQ HTT
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Apaf-1
type: Protein
entity reference: Apaf-1
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot P25857 953
type: UnificationXref
id: P25857
db: uniprot

uniprot Q96CV9 1145
type: UnificationXref
id: Q96CV9
db: uniprot

Glutamate [NMDA] receptor subunit 1
type: ProteinReference
evidence: Evidence 49
xref: uniprot Q24418 71
xref: PTHR18966:SF377
organism: Drosophila melanogaster

Rac-like GTPase
type: ProteinReference
xref: uniprot G5EBV3 1237
organism: Caenorhabditis elegans

Duo s111 sa54 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Duo
stoichiometric coefficient: 1.0

uniprot E2RU88 916
type: UnificationXref
id: E2RU88
db: uniprot

uniprot C3XYD4 243
type: UnificationXref
id: C3XYD4
db: uniprot

Apaf-1
type: Protein
entity reference: Apaf-1
feature: ACTIVE 84
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot Q7PXC4 556
type: UnificationXref
id: Q7PXC4
db: uniprot

ncbitaxon 559292 104
type: UnificationXref
id: 559292
db: ncbitaxon

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF88
xref: uniprot A0A0R4IXC8 716
organism: Danio rerio

uniprot P61205 1461
type: UnificationXref
id: P61205
db: uniprot

PARTICIPANT STOICHIOMETRY r81 1660
type: Stoichiometry
physical entity: Htt
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r81 1661
type: Stoichiometry
physical entity: Complex (Hip-12/Hip-1/ Clathrin/alpha-Adaptin/ Htt/Actin)
stoichiometric coefficient: 1.0

SH3GL3
type: ProteinReference
xref: P00813
standard name: Src homology region 3-containing Grb2-like protein 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.SH3GL3
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Endophilin-A3
member entity reference: SH3 domain containing GRB2 like 3, endophilin A3

uniprot P54257 612
type: UnificationXref
id: P54257
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P04637 700
xref: PTHR11447:SF6
organism: Homo sapiens

Brain-derived neurotrophic factor
type: DnaReference
xref: PTHR11589:SF3
organism: Gallus gallus

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 13

uniprot P42260 647
type: UnificationXref
id: P42260
db: uniprot

uniprot F6ZLR4 129
type: UnificationXref
id: F6ZLR4
db: uniprot

Calpain small subunit 1
type: ProteinReference
xref: PTHR46735:SF1
xref: uniprot P04632 149
organism: Homo sapiens

Cytoplasmic FMR1-interacting protein 1
type: ProteinReference
xref: uniprot Q7TMB8 709
organism: Mus musculus

uniprot O94111 517
type: UnificationXref
id: O94111
db: uniprot

AP-2 complex subunit alpha-2
type: ProteinReference
xref: uniprot O94973 885
xref: PTHR22780:SF30
organism: Homo sapiens

Mitogen-activated protein kinase kinase 4A
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot B1NA68 1322
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot F7E905 1007
organism: Monodelphis domestica

uniprot M9PJG1 1122
type: UnificationXref
id: M9PJG1
db: uniprot

Calpain-9
type: ProteinReference
xref: PTHR10183:SF385
xref: uniprot O35920 145
organism: Rattus norvegicus

Huntingtin-interacting protein 1-related
type: ProteinReference
xref: uniprot F1LML7 1085
organism: Rattus norvegicus

Actin-1
type: ProteinReference
xref: uniprot Q10DV7 368
xref: PTHR11937:SF469
organism: Oryza sativa

uniprot O88485 515
type: UnificationXref
id: O88485
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q38AR9 967
organism: Trypanosoma brucei

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ESZ6 1233
xref: PTHR24072:SF13
organism: Monodelphis domestica

Transcription factor AP-1
type: ProteinReference
xref: uniprot P05627 1130
xref: PTHR11462:SF8
organism: Mus musculus

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 1356

uniprot P84078 1475
type: UnificationXref
id: P84078
db: uniprot

Apoptosis regulator BAX
type: DnaReference
xref: PTHR11256:SF42
organism: Rattus norvegicus

PSD-95
type: Protein
entity reference: PSD-95
feature: COMPLEX PARTICIPANT BINDING FEATURE s101 sa50 1605
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot Q13003 651
type: UnificationXref
id: Q13003
db: uniprot

AGAP011441-PA
type: ProteinReference
xref: PTHR10676:SF387
xref: uniprot Q7Q319 559
organism: Anopheles gambiae

uniprot E1BK87 30
type: UnificationXref
id: E1BK87
db: uniprot

Rho-related GTP-binding protein RhoQ
type: ProteinReference
xref: uniprot Q9JJL4 1301
xref: PTHR24072:SF13
organism: Rattus norvegicus

Apoptosis regulator BAX
type: DnaReference
xref: PTHR11256:SF42
organism: Homo sapiens

uniprot A8XQS8 1211
type: UnificationXref
id: A8XQS8
db: uniprot

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF20
xref: uniprot P29037 1340
organism: Mus musculus

Complex (Htt/SH3GL3/ PACSIN-1/Synaptojanin/ N-Wasp)
type: Complex
component stoichiometry: Htt s73 sa29 STOICHIOMETRY ID COMPLEX
component stoichiometry: N Wasp s79 sa33 STOICHIOMETRY ID COMPLEX
component stoichiometry: Synaptojanin s78 sa32 STOICHIOMETRY ID COMPLEX
component stoichiometry: SH3GL3 s74 sa30 STOICHIOMETRY ID COMPLEX
component stoichiometry: PACSIN 1 s77 sa31 STOICHIOMETRY ID COMPLEX
component: Htt
component: N-Wasp
component: SH3GL3
component: Synaptojanin
component: PACSIN-1
feature: COMPLEX BINDING FEATURE s136 a173 1590
feature: COMPLEX BINDING FEATURE s136 a173 1586
feature: COMPLEX BINDING FEATURE s136 a173 1588
feature: COMPLEX BINDING FEATURE s136 a173 1592
feature: COMPLEX BINDING FEATURE s136 a173 1584
cellular location: clathrin coat of endocytic vesicle

Dynein light chain
type: ProteinReference
xref: uniprot A7RVI5 447
xref: PTHR11886:SF35
organism: Nematostella vectensis

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF310
xref: uniprot E9HEX5 751
organism: Daphnia pulex

Calpain 1
type: ProteinReference
xref: uniprot A0A2I3RT65 111
xref: PTHR10183:SF284
organism: Pan troglodytes

uniprot Q02779 1081
type: UnificationXref
id: Q02779
db: uniprot

JNK-2
type: Protein
entity reference: JNK-2
feature: ACTIVE 84
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Glr2859 protein
type: DnaReference
xref: PTHR43677:SF4
organism: Gloeobacter violaceus

uniprot Q8R5M4 1143
type: UnificationXref
id: Q8R5M4
db: uniprot

uniprot Q32PX6 1273
type: UnificationXref
id: Q32PX6
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot W4XHC0 868
organism: Strongylocentrotus purpuratus

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r11
controller: NMDA receptor

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot Q01112 1264
organism: Schizosaccharomyces pombe

uniprot I2CYF0 300
type: UnificationXref
id: I2CYF0
db: uniprot

Puccinia graminis
type: BioSource
xref: ncbitaxon 418459 256

Actin
type: ProteinReference
xref: uniprot P90623 364
xref: PTHR11937:SF387
organism: Trichomonas vaginalis

AP-2 complex subunit alpha
type: ProteinReference
xref: PTHR22780:SF4
xref: uniprot A8XNZ9 880
organism: Caenorhabditis briggsae

STATE_TRANSITION
type: RelationshipTypeVocabulary

YALI0D26315p
type: ProteinReference
xref: PTHR12346:SF0
xref: uniprot F2Z640 90
organism: Yarrowia lipolytica

Hip 1 s65 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Hip-1
stoichiometric coefficient: 1.0

Htt s91 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Htt
stoichiometric coefficient: 1.0

uniprot B0BM87 452
type: UnificationXref
id: B0BM87
db: uniprot

ncbitaxon 7739 235
type: UnificationXref
id: 7739
db: ncbitaxon

STATE_TRANSITION_LEFT__Truncated_Htt-RIGHT__Truncated_Htt-_r46
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 1687
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 1686
left: Truncated Htt
interaction type: STATE_TRANSITION
right: Truncated Htt

Apoptotic protease-activating factor 1
type: ProteinReference
xref: PTHR22845:SF5
xref: uniprot H2R1S6 1112
organism: Pan troglodytes

uniprot P40940 1453
type: UnificationXref
id: P40940
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10126:SF20
xref: uniprot F6SEF6 1330
organism: Macaca mulatta

uniprot A0A2I3TQ02 113
type: UnificationXref
id: A0A2I3TQ02
db: uniprot

uniprot P0C540 309
type: UnificationXref
id: P0C540
db: uniprot

Tubulin beta-1 chain
type: ProteinReference
xref: uniprot P12456 798
xref: PTHR11588:SF293
organism: Caenorhabditis elegans

Dynein complex
type: Protein
entity reference: Dynein complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s68 sa25 1561
cellular location: clathrin coat of endocytic vesicle
comment: SPECIES_TYPE=PROTEIN

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q12731 1343
organism: Emericella nidulans

uniprot P23560 597
type: UnificationXref
id: P23560
db: uniprot

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: PTHR10709:SF2
xref: uniprot Q9SJW6 1064
organism: Arabidopsis thaliana

Histone acetyltransferase HAC5
type: ProteinReference
xref: uniprot Q9LE42 1018
xref: PTHR13808:SF30
organism: Arabidopsis thaliana

ADP ribosylation factor like GTPase 4D
type: ProteinReference
xref: uniprot E2R9P6 1396
xref: PTHR11711:SF137
organism: Canis lupus familiaris

Major actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P07830 308
organism: Dictyostelium discoideum

uniprot Q9C1M7 576
type: UnificationXref
id: Q9C1M7
db: uniprot

ncbitaxon 243232 1352
type: UnificationXref
id: 243232
db: ncbitaxon

Tubulin beta chain
type: ProteinReference
xref: uniprot F1QKY8 754
xref: PTHR11588:SF55
organism: Danio rerio

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot F1PFN3 919
xref: PTHR10836:SF111
organism: Canis lupus familiaris

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot P15153 1243
xref: PTHR24072:SF169
organism: Homo sapiens

ncbitaxon 5759 227
type: UnificationXref
id: 5759
db: ncbitaxon

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 29

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 48

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF158
xref: uniprot F7A4B3 1231
organism: Monodelphis domestica

uniprot P61285 525
type: UnificationXref
id: P61285
db: uniprot

Actin-3
type: ProteinReference
xref: uniprot P07829 307
xref: PTHR11937:SF421
organism: Dictyostelium discoideum

Actin-18
type: ProteinReference
xref: uniprot P07828 305
xref: PTHR11937:SF421
organism: Dictyostelium discoideum

Dynein light chain
type: ProteinReference
xref: uniprot C3YNF2 456
xref: PTHR11886:SF35
organism: Branchiostoma floridae

uniprot Q6UK63 706
type: UnificationXref
id: Q6UK63
db: uniprot

uniprot E1BMR6 1120
type: UnificationXref
id: E1BMR6
db: uniprot

Quinone oxidoreductase
type: DnaReference
organism: Rhodopirellula baltica

Brain-derived neurotrophic factor (Fragment)
type: ProteinReference
xref: uniprot O02795 595
xref: PTHR11589:SF3
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GL73 292
xref: PTHR11937:SF176
organism: Monodelphis domestica

uniprot P04632 149
type: UnificationXref
id: P04632
db: uniprot

Tumor protein p73
type: ProteinReference
xref: uniprot Q9JJP2 713
xref: PTHR11447:SF21
organism: Mus musculus

uniprot Q6Z7L8 1289
type: UnificationXref
id: Q6Z7L8
db: uniprot

Tumor protein 63
type: ProteinReference
xref: uniprot Q9JJP6 714
xref: PTHR11447:SF8
organism: Rattus norvegicus

uniprot A0A2I3TXK9 114
type: UnificationXref
id: A0A2I3TXK9
db: uniprot

uniprot H2QXW1 1043
type: UnificationXref
id: H2QXW1
db: uniprot

PARTICIPANT STOICHIOMETRY r81 1658
type: Stoichiometry
physical entity: Clathrin
stoichiometric coefficient: 1.0

Actin, alpha 2, smooth muscle, aorta
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot F7F4W9 291
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r81 1659
type: Stoichiometry
physical entity: Actin
stoichiometric coefficient: 8.0

uniprot F7HFY2 1147
type: UnificationXref
id: F7HFY2
db: uniprot

PARTICIPANT STOICHIOMETRY r81 1656
type: Stoichiometry
physical entity: Complex (Hip-12/Hip-1)
stoichiometric coefficient: 1.0

uniprot F1NN08 1406
type: UnificationXref
id: F1NN08
db: uniprot

PARTICIPANT STOICHIOMETRY r81 1657
type: Stoichiometry
physical entity: alpha-Adaptin
stoichiometric coefficient: 1.0

Predicted protein
type: ProteinReference
xref: uniprot A7SCN8 205
xref: PTHR11937:SF387
organism: Nematostella vectensis

uniprot F1NMB0 35
type: UnificationXref
id: F1NMB0
db: uniprot

uniprot F7ALP7 1423
type: UnificationXref
id: F7ALP7
db: uniprot

uniprot A0A1D5Q7K7 187
type: UnificationXref
id: A0A1D5Q7K7
db: uniprot

ADP-ribosylation factor, putative
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot Q8IJ63 1520
organism: Plasmodium falciparum

uniprot Q7PZ49 1514
type: UnificationXref
id: Q7PZ49
db: uniprot

uniprot Q99PE9 1522
type: UnificationXref
id: Q99PE9
db: uniprot

uniprot E2REM0 1188
type: UnificationXref
id: E2REM0
db: uniprot

Tubulin beta-4 chain
type: ProteinReference
xref: PTHR11588:SF280
xref: uniprot P45960 807
organism: Oryza sativa

uniprot E2RNQ7 1400
type: UnificationXref
id: E2RNQ7
db: uniprot

Htt s3 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Htt
stoichiometric coefficient: 1.0

uniprot A0A3Q1NEU9 444
type: UnificationXref
id: A0A3Q1NEU9
db: uniprot

Arfaptin-2
type: ProteinReference
xref: uniprot Q3ZCL5 1100
xref: PTHR12141:SF3
organism: Bos taurus

uniprot A9TYG3 221
type: UnificationXref
id: A9TYG3
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__MLK_2-RIGHT__MLK_2-_r13
control type: ACTIVATION
controller: Ca2+

PARTICIPANT STOICHIOMETRY r66 1715
type: Stoichiometry
physical entity: Arp2/3 complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r66 1714
type: Stoichiometry
physical entity: Arp2/3 complex
stoichiometric coefficient: 1.0

uniprot Q9Z0W5 19
type: UnificationXref
id: Q9Z0W5
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q4Q6Z4 968
organism: Leishmania major

uniprot F6TAI6 92
type: UnificationXref
id: F6TAI6
db: uniprot

uniprot Q86KI1 895
type: UnificationXref
id: Q86KI1
db: uniprot

uniprot Q4Q6Z4 968
type: UnificationXref
id: Q4Q6Z4
db: uniprot

uniprot H2QMU4 1434
type: UnificationXref
id: H2QMU4
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q4Q6Z5 969
organism: Leishmania major

uniprot H2QN22 1088
type: UnificationXref
id: H2QN22
db: uniprot

Dynein heavy chain, cytoplasmic
type: ProteinReference
xref: uniprot Q9C1M7 576
xref: PTHR10676:SF314
organism: Ashbya gossypii

Vesicle amine transport 1 like
type: DnaReference
xref: PTHR44054:SF2
organism: Pan troglodytes

ADP-ribosylation factor 6
type: ProteinReference
xref: PTHR11711:SF379
xref: uniprot P62331 1472
organism: Mus musculus

Tubulin beta-4A chain
type: ProteinReference
xref: PTHR11588:SF253
xref: uniprot Q9D6F9 863
organism: Mus musculus

ADP-ribosylation factor 6
type: ProteinReference
xref: PTHR11711:SF379
xref: uniprot P62332 1473
organism: Rattus norvegicus

ADP-ribosylation factor 6
type: ProteinReference
xref: PTHR11711:SF379
xref: uniprot P62330 1471
organism: Homo sapiens

uniprot C3XYC2 234
type: UnificationXref
id: C3XYC2
db: uniprot

uniprot P28023 1317
type: UnificationXref
id: P28023
db: uniprot

uniprot F1A084 1224
type: UnificationXref
id: F1A084
db: uniprot

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q60823 1173
xref: PTHR24356:SF176
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QUB5 1133
organism: Macaca mulatta

uniprot Q922F4 859
type: UnificationXref
id: Q922F4
db: uniprot

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 950

Glutamate receptor ionotropic, kainate 5
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot Q16478 653
organism: Homo sapiens

AP-2 complex subunit alpha-1
type: ProteinReference
xref: PTHR22780:SF4
xref: uniprot Q8LPL6 897
organism: Arabidopsis thaliana

Actin-2
type: ProteinReference
xref: PTHR11937:SF430
xref: uniprot Q96292 409
organism: Arabidopsis thaliana

uniprot P53488 326
type: UnificationXref
id: P53488
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot Q75BP6 850
xref: PTHR11588:SF9
organism: Ashbya gossypii

uniprot O13290 512
type: UnificationXref
id: O13290
db: uniprot

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot Q5ZMQ2 384
organism: Gallus gallus

Synaptojanin
type: Protein
entity reference: Synaptojanin
feature: COMPLEX PARTICIPANT BINDING FEATURE s78 sa32 1591
cellular location: clathrin coat of endocytic vesicle
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__JNK_2-RIGHT__JNK_2-_r17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 1668
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 1667
left: JNK-2
interaction type: STATE_TRANSITION
right: JNK-2

uniprot P52275 808
type: UnificationXref
id: P52275
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: PTHR48013:SF20
xref: uniprot P45985 615
organism: Homo sapiens

uniprot E2QXY7 254
type: UnificationXref
id: E2QXY7
db: uniprot

Quinone oxidoreductase
type: DnaReference
xref: PTHR44154:SF1
organism: Mus musculus

uniprot P18085 1446
type: UnificationXref
id: P18085
db: uniprot

uniprot O00909 1442
type: UnificationXref
id: O00909
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P45984 606
xref: PTHR24055:SF172
organism: Homo sapiens

AP-2 complex subunit alpha-2
type: ProteinReference
xref: PTHR22780:SF4
xref: uniprot Q8LPK4 896
organism: Arabidopsis thaliana

uniprot F7FYA6 1426
type: UnificationXref
id: F7FYA6
db: uniprot

ncbitaxon 6669 258
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot F6URT1 1418
type: UnificationXref
id: F6URT1
db: uniprot

PTHR16011:SF0
type: RelationshipXref
id: PTHR16011:SF0
db: PANTHER Family
relationship type: By Homology

uniprot P07487 937
type: UnificationXref
id: P07487
db: uniprot

Calpain-1 catalytic subunit
type: ProteinReference
xref: PTHR10183:SF322
xref: uniprot P00789 148
organism: Gallus gallus

ADP-ribosylation factor-like protein 4D
type: ProteinReference
xref: PTHR11711:SF137
xref: uniprot F6URI0 1417
organism: Macaca mulatta

uniprot W4ZD41 417
type: UnificationXref
id: W4ZD41
db: uniprot

Dynein light chain
type: ProteinReference
xref: uniprot Q6DEU5 550
xref: PTHR11886:SF89
organism: Xenopus tropicalis

uniprot O94973 885
type: UnificationXref
id: O94973
db: uniprot

Tubulin beta-2 chain
type: ProteinReference
xref: PTHR11588:SF376
xref: uniprot P52275 808
organism: Caenorhabditis elegans

uniprot F1PWT6 634
type: UnificationXref
id: F1PWT6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Rac_GDP_-_GTP-RIGHT__Complex__Rac_GTP_-_GDP-_r75
controller: Complex (NMDA receptor/PSD-95/ Kainate receptor/Htt/ HAP1/Duo)

Uncharacterized protein
type: ProteinReference
xref: uniprot F0Z796 262
xref: PTHR11937:SF421
organism: Dictyostelium purpureum

uniprot P29516 800
type: UnificationXref
id: P29516
db: uniprot

CREB-binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot Q92793 1014
organism: Homo sapiens

uniprot P53478 325
type: UnificationXref
id: P53478
db: uniprot

Tubulin beta-8 chain
type: ProteinReference
xref: uniprot Q3ZCM7 827
xref: PTHR11588:SF55
organism: Homo sapiens

uniprot Q60520 105
type: UnificationXref
id: Q60520
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot F7B0P2 764
xref: PTHR11588:SF88
organism: Ornithorhynchus anatinus

uniprot A0A1D5QUB5 1133
type: UnificationXref
id: A0A1D5QUB5
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot H2QXW1 1043
xref: PTHR12644:SF2
organism: Pan troglodytes

Intraflagellar transport 57
type: ProteinReference
xref: uniprot F1P6B8 1086
xref: PTHR16011:SF0
organism: Canis lupus familiaris

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF37
xref: uniprot E2QXY7 254
organism: Canis lupus familiaris

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6QE96 1161
xref: PTHR24356:SF176
organism: Macaca mulatta

Hydroxyproline dehydrogenase
type: DnaReference
organism: Homo sapiens

TRANSCRIPTION
type: InteractionVocabulary

Uncharacterized protein
type: ProteinReference
xref: PTHR13992:SF21
xref: uniprot A0A1D5RHE4 1364
organism: Macaca mulatta

uniprot D3ZRN3 253
type: UnificationXref
id: D3ZRN3
db: uniprot

uniprot Q75D00 396
type: UnificationXref
id: Q75D00
db: uniprot

CAPN9 isoform 1
type: ProteinReference
xref: uniprot H2Q1B8 133
xref: PTHR10183:SF385
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1PRG4 1159
xref: PTHR24356:SF176
organism: Canis lupus familiaris

Tubulin beta chain
type: ProteinReference
xref: uniprot F1NYB1 753
xref: PTHR11588:SF247
organism: Gallus gallus

uniprot Q61644 14
type: UnificationXref
id: Q61644
db: uniprot

uniprot F6SEF6 1330
type: UnificationXref
id: F6SEF6
db: uniprot

PARTICIPANT STOICHIOMETRY r11 1697
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 1698
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Putative ADP-ribosylation factor
type: ProteinReference
xref: uniprot Q9U0T6 1527
xref: PTHR11711:SF396
organism: Leishmania major

uniprot P07486 936
type: UnificationXref
id: P07486
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF376
xref: uniprot A8XX81 732
organism: Caenorhabditis briggsae

ACTA1 isoform 1
type: ProteinReference
xref: PTHR11937:SF193
xref: uniprot H2Q1A9 295
organism: Pan troglodytes

Quinone oxidoreductase
type: DnaReference
xref: PTHR44154:SF1
organism: Homo sapiens

uniprot P63168 527
type: UnificationXref
id: P63168
db: uniprot

TAFII130 s20 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TAFII130
stoichiometric coefficient: 1.0

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 982

Sin3A
type: Protein
entity reference: Sin3A
feature: COMPLEX PARTICIPANT BINDING FEATURE s44 sa15 1643
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q8TI26 1355
type: UnificationXref
id: Q8TI26
db: uniprot

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 996

uniprot Q22799 535
type: UnificationXref
id: Q22799
db: uniprot

Vesicle amine transport 1
type: DnaReference
xref: PTHR44054:SF1
organism: Xenopus tropicalis

uniprot H2QVB1 1435
type: UnificationXref
id: H2QVB1
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot A0A2I3TC58 719
xref: PTHR11588:SF55
organism: Pan troglodytes

uniprot Q4KSH7 1308
type: UnificationXref
id: Q4KSH7
db: uniprot

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 1352

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF150
xref: uniprot F7CIV4 286
organism: Ornithorhynchus anatinus

uniprot A7S8I3 726
type: UnificationXref
id: A7S8I3
db: uniprot

Tubulin beta-2A chain
type: ProteinReference
xref: uniprot Q13885 818
xref: PTHR11588:SF100
organism: Homo sapiens

uniprot A8XX81 732
type: UnificationXref
id: A8XX81
db: uniprot

Dynein light chain
type: ProteinReference
xref: uniprot E9H8L6 467
xref: PTHR11886:SF35
organism: Daphnia pulex

Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic
type: ProteinReference
xref: uniprot Q7FAH2 977
organism: Oryza sativa

Htt s34 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Htt
stoichiometric coefficient: 1.0

Dynein light chain
type: ProteinReference
xref: uniprot F7AP66 490
xref: PTHR11886:SF73
organism: Macaca mulatta

PolyQ Htt s51 a68 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot B7PA95 738
type: UnificationXref
id: B7PA95
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot H2QG30 923
organism: Pan troglodytes

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot F1NE09 680
organism: Gallus gallus

uniprot Q94469 988
type: UnificationXref
id: Q94469
db: uniprot

Actin 5
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9TZ58 223
organism: Physcomitrella patens

ncbitaxon 190304 985
type: UnificationXref
id: 190304
db: ncbitaxon

uniprot Q9SSX0 1302
type: UnificationXref
id: Q9SSX0
db: uniprot

uniprot F6TYN8 760
type: UnificationXref
id: F6TYN8
db: uniprot

uniprot Q9JHU4 580
type: UnificationXref
id: Q9JHU4
db: uniprot

ncbitaxon 8364 44
type: UnificationXref
id: 8364
db: ncbitaxon

Tubulin beta chain
type: ProteinReference
xref: uniprot Q4QI42 833
xref: PTHR11588:SF9
organism: Leishmania major

Ca2+
type: SmallMolecule
cellular location: synapse
comment: SPECIES_TYPE=ION

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot Q7ZUQ0 1058
xref: PTHR10709:SF11
organism: Danio rerio

uniprot P02557 785
type: UnificationXref
id: P02557
db: uniprot

uniprot A8XS95 215
type: UnificationXref
id: A8XS95
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF477
xref: uniprot F6QWB7 272
organism: Ornithorhynchus anatinus

Actin-related protein 2/3 complex subunit 1A
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot Q92747 1060
organism: Homo sapiens

Tubulin beta chain
type: ProteinReference
xref: uniprot W4YEV4 873
organism: Strongylocentrotus purpuratus

PolyQ Htt
type: Protein
entity reference: PolyQ Htt
feature: PolyQ Htt s9 sa2 rs1

ncbitaxon 224308 926
type: UnificationXref
id: 224308
db: ncbitaxon

ADP-ribosylation factor A1F
type: ProteinReference
xref: uniprot Q6ID97 1502
xref: PTHR11711:SF340
organism: Arabidopsis thaliana

uniprot A9RQS1 733
type: UnificationXref
id: A9RQS1
db: uniprot

uniprot O60229 1534
type: UnificationXref
id: O60229
db: uniprot

uniprot A7SHY4 727
type: UnificationXref
id: A7SHY4
db: uniprot

PolyQ Htt s61 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 1.0

ADP-ribosylation factor 1
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot A7EN31 1378
organism: Sclerotinia sclerotiorum

uniprot Q78AP9 1510
type: UnificationXref
id: Q78AP9
db: uniprot

AP-2 complex subunit alpha
type: ProteinReference
xref: uniprot F6QED1 882
xref: PTHR22780:SF30
organism: Macaca mulatta

ncbitaxon 9258 95
type: UnificationXref
id: 9258
db: ncbitaxon

CREB-binding protein isoform a
type: ProteinReference
xref: uniprot F6RRA8 1005
xref: PTHR13808:SF34
organism: Macaca mulatta

STATE_TRANSITION_LEFT__PolyQ_Htt-RIGHT__PolyQ_Htt-_r38
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 1707
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 1708
left: PolyQ Htt
interaction type: STATE_TRANSITION
right: PolyQ Htt

uniprot Q4QIT8 1200
type: UnificationXref
id: Q4QIT8
db: uniprot

uniprot P62999 1258
type: UnificationXref
id: P62999
db: uniprot

uniprot Q9XGU0 1304
type: UnificationXref
id: Q9XGU0
db: uniprot

uniprot A0A1D5Q8J6 877
type: UnificationXref
id: A0A1D5Q8J6
db: uniprot

Huntingtin
type: DnaReference
xref: PTHR10170:SF10
organism: Rattus norvegicus

uniprot F6S5B1 635
type: UnificationXref
id: F6S5B1
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot E9GF36 917
organism: Daphnia pulex

Rac family small GTPase 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q6GL60 1286
organism: Xenopus tropicalis

Tubulin beta chain
type: ProteinReference
xref: uniprot E9GER1 750
xref: PTHR11588:SF9
organism: Daphnia pulex

STATE_TRANSITION_LEFT__PolyQ_Htt-RIGHT__PolyQ_Htt-_r20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 1746
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 1747
left: PolyQ Htt
interaction type: STATE_TRANSITION
right: PolyQ Htt

uniprot H2QA01 1180
type: UnificationXref
id: H2QA01
db: uniprot

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot A0A2I3RKD8 671
organism: Pan troglodytes

PTHR23202:SF39
type: RelationshipXref
id: PTHR23202:SF39
db: PANTHER Family
relationship type: By Homology

uniprot F1PCE1 1407
type: UnificationXref
id: F1PCE1
db: uniprot

PARTICIPANT STOICHIOMETRY r30 1720
type: Stoichiometry
physical entity: Apaf-1
stoichiometric coefficient: 1.0

uniprot P38328 1049
type: UnificationXref
id: P38328
db: uniprot

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: PTHR10709:SF10
xref: uniprot Q9WV32 1065
organism: Mus musculus

uniprot P20445 951
type: UnificationXref
id: P20445
db: uniprot

uniprot Q9D805 171
type: UnificationXref
id: Q9D805
db: uniprot

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot F6PFV4 684
organism: Ornithorhynchus anatinus

uniprot Q02647 529
type: UnificationXref
id: Q02647
db: uniprot

uniprot A0A2I3TC58 719
type: UnificationXref
id: A0A2I3TC58
db: uniprot

uniprot H2REF4 179
type: UnificationXref
id: H2REF4
db: uniprot

Dynein light chain
type: ProteinReference
xref: uniprot B3RJW0 453
xref: PTHR11886:SF35
organism: Trichoplax adhaerens

uniprot Q4QQV0 834
type: UnificationXref
id: Q4QQV0
db: uniprot

uniprot H9FPA8 137
type: UnificationXref
id: H9FPA8
db: uniprot

Complex (N-CoR/Htt/ Sin3A)
type: Complex
component stoichiometry: N CoR s30 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: Sin3A s44 sa15 STOICHIOMETRY ID COMPLEX
component stoichiometry: Htt s34 sa14 STOICHIOMETRY ID COMPLEX
component: N-CoR
component: Sin3A
component: Htt
feature: COMPLEX BINDING FEATURE s75 a101 1638
feature: COMPLEX BINDING FEATURE s75 a101 1642
feature: COMPLEX BINDING FEATURE s75 a101 1640
cellular location: nucleus

NADPH:quinone reductase
type: DnaReference
xref: PTHR43677:SF4
organism: Methanosarcina acetivorans

IDA
type: EvidenceCodeVocabulary

Glutamate receptor ionotropic, NMDA 2C
type: ProteinReference
evidence: Evidence 49
evidence: Evidence 54
xref: uniprot Q14957 70
xref: PTHR18966:SF361
organism: Homo sapiens

Apoptotic protease-activating factor 1
type: ProteinReference
xref: PTHR22845:SF5
xref: uniprot Q9I9H8 1115
organism: Danio rerio

uniprot F7GR67 45
type: UnificationXref
id: F7GR67
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PolyQ_Htt-RIGHT__PolyQ_Htt-_r20
controller: Akt

Glutamate receptor ionotropic, kainate 2
type: ProteinReference
xref: PTHR18966:SF38
xref: uniprot Q13002 650
organism: Homo sapiens

Glutamate receptor ionotropic, kainate 3
type: ProteinReference
xref: PTHR18966:SF174
xref: uniprot Q13003 651
organism: Homo sapiens

uniprot O35668 610
type: UnificationXref
id: O35668
db: uniprot

uniprot E1C7N2 460
type: UnificationXref
id: E1C7N2
db: uniprot

PARTICIPANT STOICHIOMETRY r30 1719
type: Stoichiometry
physical entity: Apaf-1
stoichiometric coefficient: 1.0

Dynein axonemal heavy chain 8
type: ProteinReference
xref: PTHR10676:SF361
xref: uniprot A0A2I3S5A4 440
organism: Pan troglodytes

uniprot P05219 787
type: UnificationXref
id: P05219
db: uniprot

uniprot Q5M7U6 381
type: UnificationXref
id: Q5M7U6
db: uniprot

uniprot P63267 347
type: UnificationXref
id: P63267
db: uniprot

uniprot Q18817 819
type: UnificationXref
id: Q18817
db: uniprot

uniprot F7FN64 690
type: UnificationXref
id: F7FN64
db: uniprot

Mitogen-activated protein kinase kinase kinase 10
type: ProteinReference
xref: uniprot Q02779 1081
organism: Homo sapiens

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF88
xref: uniprot E2QYC2 746
organism: Canis lupus familiaris

Neural Wiskott-Aldrich syndrome protein
type: ProteinReference
xref: PTHR23202:SF39
xref: uniprot Q95107 1073
organism: Bos taurus

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot Q4GYY6 830
organism: Trypanosoma brucei

uniprot A0A2I3SL91 441
type: UnificationXref
id: A0A2I3SL91
db: uniprot

Brain-derived neurotrophic factor
type: ProteinReference
xref: uniprot Q95106 601
xref: PTHR11589:SF3
organism: Bos taurus

uniprot A0A2I3T9Y4 1153
type: UnificationXref
id: A0A2I3T9Y4
db: uniprot

uniprot P13496 1316
type: UnificationXref
id: P13496
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A567 1232
organism: Monodelphis domestica

uniprot P47196 1171
type: UnificationXref
id: P47196
db: uniprot

Cdc42 homolog
type: ProteinReference
xref: uniprot Q17031 1269
organism: Anopheles gambiae

uniprot P47197 1172
type: UnificationXref
id: P47197
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: Apaf-1

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF20
xref: uniprot Q28GG8 1345
organism: Xenopus tropicalis

uniprot Q7FAH2 977
type: UnificationXref
id: Q7FAH2
db: uniprot

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot A0A2R8PX02 672
organism: Danio rerio

uniprot Q0DJC3 1198
type: UnificationXref
id: Q0DJC3
db: uniprot

uniprot A2DC16 722
type: UnificationXref
id: A2DC16
db: uniprot

uniprot Q8R527 1295
type: UnificationXref
id: Q8R527
db: uniprot

ADP ribosylation factor 6
type: ProteinReference
xref: PTHR11711:SF379
xref: uniprot F6URT1 1418
organism: Ornithorhynchus anatinus

uniprot E7EXT6 1157
type: UnificationXref
id: E7EXT6
db: uniprot

PolyQ Htt s54 a73 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 8.0

uniprot Q7JWS8 1291
type: UnificationXref
id: Q7JWS8
db: uniprot

Dynein complex s68 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Dynein complex
stoichiometric coefficient: 1.0

uniprot F6XSJ9 1229
type: UnificationXref
id: F6XSJ9
db: uniprot

Glutamate receptor ionotropic, NMDA 2D
type: ProteinReference
evidence: Evidence 49
evidence: Evidence 54
evidence: Evidence 55
xref: uniprot Q03391 66
xref: PTHR18966:SF385
organism: Mus musculus

uniprot Q9TU25 1303
type: UnificationXref
id: Q9TU25
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MK42 1225
xref: PTHR24072:SF13
organism: Bos taurus

Tubulin beta-2A chain
type: ProteinReference
xref: uniprot Q7TMM9 856
xref: PTHR11588:SF100
organism: Mus musculus

uniprot B1N2P0 226
type: UnificationXref
id: B1N2P0
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 321

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF306
xref: uniprot F0ZI20 752
organism: Dictyostelium purpureum

FIP 2 s90 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FIP-2
stoichiometric coefficient: 1.0

Membrane depolarization
type: Pathway

uniprot A2DHT2 900
type: UnificationXref
id: A2DHT2
db: uniprot

Proline oxidase
type: DnaRegionReference
member entity reference: Hydroxyproline dehydrogenase
member entity reference: Proline dehydrogenase 1, mitochondrial
member entity reference: Proline dehydrogenase, mitochondrial
member entity reference: Proline dehydrogenase
member entity reference: Probable proline dehydrogenase, mitochondrial
member entity reference: GroES-like zinc-binding alcohol dehydrogenase family protein
xref: G01529
comment: ENTITY_REFERENCE_NOTES= Long Name: Proline oxidase Synonym: Synonym not specified Accession: G01529
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.GENE.GENE.Proline_br_oxidase

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot Q7ZVI7 403
xref: PTHR11937:SF362
organism: Danio rerio

uniprot Q9P8C0 994
type: UnificationXref
id: Q9P8C0
db: uniprot

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF2
xref: uniprot A1Z8T9 445
organism: Drosophila melanogaster

uniprot P61006 1029
type: UnificationXref
id: P61006
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9TYG6 222
organism: Physcomitrella patens

Ras homolog family member Q
type: ProteinReference
xref: uniprot Q7ZVI3 1293
xref: PTHR24072:SF13
organism: Danio rerio

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 1536

Predicted protein
type: ProteinReference
xref: uniprot A9TYG3 221
xref: PTHR11937:SF387
organism: Physcomitrella patens

uniprot Q0IIR4 816
type: UnificationXref
id: Q0IIR4
db: uniprot

uniprot Q8WP14 858
type: UnificationXref
id: Q8WP14
db: uniprot

uniprot Q3ZCM7 827
type: UnificationXref
id: Q3ZCM7
db: uniprot

uniprot A8XT67 1031
type: UnificationXref
id: A8XT67
db: uniprot

uniprot E2RGK6 10
type: UnificationXref
id: E2RGK6
db: uniprot

uniprot F6YBQ8 637
type: UnificationXref
id: F6YBQ8
db: uniprot

uniprot C3ZTX6 252
type: UnificationXref
id: C3ZTX6
db: uniprot

uniprot P42574 1149
type: UnificationXref
id: P42574
db: uniprot

uniprot E9FRT1 257
type: UnificationXref
id: E9FRT1
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot Q6NW90 841
xref: PTHR11588:SF61
organism: Danio rerio

uniprot K7CAG5 1138
type: UnificationXref
id: K7CAG5
db: uniprot

uniprot Q00961 63
type: UnificationXref
id: Q00961
db: uniprot

uniprot P54118 959
type: UnificationXref
id: P54118
db: uniprot

uniprot F7B5L8 604
type: UnificationXref
id: F7B5L8
db: uniprot

uniprot Q9Y243 1175
type: UnificationXref
id: Q9Y243
db: uniprot

uniprot O14576 513
type: UnificationXref
id: O14576
db: uniprot

Caspase 3
type: Protein
entity reference: Caspase 3
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__PolyQ_HTT-RIGHT__PolyQ_HTT-_re79
control type: ACTIVATION
controller: Iron

ACTC1 isoform 1
type: ProteinReference
xref: uniprot H2Q943 296
xref: PTHR11937:SF176
organism: Pan troglodytes

uniprot Q5E924 972
type: UnificationXref
id: Q5E924
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 104

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 72

NMDA receptor
type: Protein
entity reference: NMDA receptor
feature: ACTIVE 84
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot Q4KKX4 1370
type: UnificationXref
id: Q4KKX4
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot A7SJX9 728
xref: PTHR11588:SF9
organism: Nematostella vectensis

Tubulin beta chain
type: ProteinReference
xref: uniprot A9SJR1 735
xref: PTHR11588:SF306
organism: Physcomitrella patens

Uncharacterized protein
type: ProteinReference
xref: PTHR12141:SF3
xref: uniprot F7FRA7 1097
organism: Monodelphis domestica

uniprot F6UXY7 481
type: UnificationXref
id: F6UXY7
db: uniprot

uniprot Q9VJP5 184
type: UnificationXref
id: Q9VJP5
db: uniprot

uniprot G5EGQ9 47
type: UnificationXref
id: G5EGQ9
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q9UVF3 414
organism: Yarrowia lipolytica

Glutamate receptor ionotropic, NMDA 2A
type: ProteinReference
evidence: Evidence 49
evidence: Evidence 58
evidence: Evidence 54
evidence: Evidence 57
xref: uniprot Q12879 68
xref: PTHR18966:SF407
organism: Homo sapiens

Caspase 3
type: Protein
entity reference: Caspase 3
feature: ACTIVE 84
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot Q8K221 1102
type: UnificationXref
id: Q8K221
db: uniprot

Dynein, cytoplasmic 1, light intermediate chain 1
type: ProteinReference
xref: uniprot Q2KII9 538
xref: PTHR12688:SF2
organism: Bos taurus

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot F6XLU1 685
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot F7EU36 289
organism: Monodelphis domestica

ADP-ribosylation factor, putative, expressed
type: ProteinReference
xref: uniprot Q336M3 1489
xref: PTHR11711:SF364
organism: Oryza sativa

uniprot Q7QAB9 708
type: UnificationXref
id: Q7QAB9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q0U5H3 1268
organism: Phaeosphaeria nodorum

Uncharacterized protein
type: ProteinReference
xref: PTHR23202:SF39
xref: uniprot E2RCG1 1068
organism: Canis lupus familiaris

uniprot Q7QII4 563
type: UnificationXref
id: Q7QII4
db: uniprot

uniprot Q10AZ4 367
type: UnificationXref
id: Q10AZ4
db: uniprot

Huntingtin-interacting protein 1-related protein
type: ProteinReference
xref: uniprot Q9JKY5 1093
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF446
xref: uniprot W4ZD41 417
organism: Strongylocentrotus purpuratus

Calpain-6
type: ProteinReference
xref: PTHR10183:SF381
xref: uniprot Q9Y6Q1 177
organism: Homo sapiens

Cytoplasmatic actin
type: ProteinReference
xref: uniprot E9HGF5 261
xref: PTHR11937:SF423
organism: Daphnia pulex

uniprot Q3ZC07 371
type: UnificationXref
id: Q3ZC07
db: uniprot

Akt
type: Protein
entity reference: Akt
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

ADP ribosylation factor like GTPase 4C
type: ProteinReference
xref: uniprot F6T022 1416
xref: PTHR11711:SF119
organism: Ornithorhynchus anatinus

uniprot C3ZHN2 249
type: UnificationXref
id: C3ZHN2
db: uniprot

uniprot H2QV01 1042
type: UnificationXref
id: H2QV01
db: uniprot

eco ECO:0000250 8
type: UnificationXref
id: ECO:0000250
db: eco

uniprot Q9JJP2 713
type: UnificationXref
id: Q9JJP2
db: uniprot

PTHR11256:SF42
type: RelationshipXref
id: PTHR11256:SF42
db: PANTHER Family
relationship type: By Homology

Ras homolog family member J
type: ProteinReference
xref: PTHR24072:SF17
xref: uniprot Q5RJS2 1280
organism: Rattus norvegicus

uniprot A0A1D5QYU3 718
type: UnificationXref
id: A0A1D5QYU3
db: uniprot

uniprot Q3SZF2 1492
type: UnificationXref
id: Q3SZF2
db: uniprot

uniprot K7DEX7 511
type: UnificationXref
id: K7DEX7
db: uniprot

N Wasp s79 sa33 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: N-Wasp
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1P630 602
xref: PTHR24055:SF172
organism: Canis lupus familiaris

uniprot O88879 1114
type: UnificationXref
id: O88879
db: uniprot

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot H2Q913 693
organism: Pan troglodytes

uniprot Q7PFI3 1353
type: UnificationXref
id: Q7PFI3
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 27
evidence: Evidence 22
xref: PTHR18966:SF397
xref: uniprot F6VTB5 41
organism: Macaca mulatta

Tubulin beta chain
type: ProteinReference
xref: uniprot A7S027 725
xref: PTHR11588:SF9
organism: Nematostella vectensis

TRANSCRIPTION_LEFT__Proline_oxidase-RIGHT__Proline_oxidase-_re68
type: TemplateReaction
product: Proline oxidase
xref: TRANSCRIPTION
participant: Proline oxidase
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 44

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot F6UA54 278
organism: Macaca mulatta

Tubulin beta-3 chain
type: ProteinReference
xref: uniprot P08841 790
xref: PTHR11588:SF273
organism: Drosophila melanogaster

PTHR11937:SF37
type: RelationshipXref
id: PTHR11937:SF37
db: PANTHER Family
relationship type: By Homology

uniprot Q0VC18 1484
type: UnificationXref
id: Q0VC18
db: uniprot

TRIGGER
type: RelationshipTypeVocabulary

TATA-box-binding protein F
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q9HHE9 1361
organism: Halobacterium salinarum

uniprot P84084 1481
type: UnificationXref
id: P84084
db: uniprot

uniprot P41799 805
type: UnificationXref
id: P41799
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR48106:SF8
organism: Dictyostelium discoideum

PolyQ Htt s45 sa16 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot G5ECL2 1183
type: UnificationXref
id: G5ECL2
db: uniprot

uniprot F7CLW1 1137
type: UnificationXref
id: F7CLW1
db: uniprot

Dynein cytoplasmic 1 heavy chain 1
type: ProteinReference
xref: uniprot F1PGY9 476
xref: PTHR10676:SF314
organism: Canis lupus familiaris

uniprot H2QD01 609
type: UnificationXref
id: H2QD01
db: uniprot

Huntingtin-interacting protein 1-related protein
type: ProteinReference
xref: uniprot H9G1I6 1089
organism: Macaca mulatta

PolyQ Htt s5 a6 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PolyQ Htt
type: Protein
entity reference: PolyQ Htt
feature: PolyQ Htt s54 a73 rs1

Cytochrome c
type: Protein
entity reference: Cytochrome c
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Calpain-7
type: ProteinReference
xref: PTHR46143:SF1
xref: uniprot Q9Y6W3 178
organism: Homo sapiens

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot A0A1D5QUW3 670
organism: Macaca mulatta

Dynein heavy chain, cytoplasmic
type: ProteinReference
xref: uniprot P34036 520
xref: PTHR10676:SF314
organism: Dictyostelium discoideum

uniprot A0A1D5RHE4 1364
type: UnificationXref
id: A0A1D5RHE4
db: uniprot

Rac-like GTP-binding protein 2
type: ProteinReference
xref: uniprot Q68Y52 1283
organism: Oryza sativa

Dynein axonemal heavy chain 5
type: ProteinReference
xref: PTHR46454:SF3
xref: uniprot E1BMG2 459
organism: Bos taurus

uniprot Q00959 61
type: UnificationXref
id: Q00959
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot Q0IIR4 816
xref: PTHR11588:SF247
organism: Xenopus tropicalis

Dynein light chain 1, cytoplasmic
type: ProteinReference
xref: uniprot P63170 528
xref: PTHR11886:SF91
organism: Rattus norvegicus

ncbitaxon 208964 956
type: UnificationXref
id: 208964
db: ncbitaxon

Tubulin beta-7 chain
type: ProteinReference
xref: uniprot P37832 804
xref: PTHR11588:SF339
organism: Oryza sativa

uniprot Q8BSL7 1519
type: UnificationXref
id: Q8BSL7
db: uniprot

TRANSCRIPTION_LEFT__PIG3-RIGHT__PIG3-_re70
type: TemplateReaction
product: PIG3
xref: TRANSCRIPTION
participant: PIG3
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot A7MBI0 6
type: UnificationXref
id: A7MBI0
db: uniprot

uniprot O93417 1148
type: UnificationXref
id: O93417
db: uniprot

uniprot F1QUN8 267
type: UnificationXref
id: F1QUN8
db: uniprot

Dynein light chain 1, cytoplasmic
type: ProteinReference
xref: PTHR11886:SF84
xref: uniprot P63167 526
organism: Homo sapiens

Dynein light chain 1, cytoplasmic
type: ProteinReference
xref: PTHR11886:SF91
xref: uniprot P63168 527
organism: Mus musculus

uniprot Q9D6F9 863
type: UnificationXref
id: Q9D6F9
db: uniprot

HAP1
type: Protein
entity reference: HAP1
feature: COMPLEX PARTICIPANT BINDING FEATURE s110 sa53 1611
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

ADP ribosylation factor 6
type: ProteinReference
xref: uniprot E2RHL4 1398
xref: PTHR11711:SF379
organism: Canis lupus familiaris

AP-2 complex subunit alpha
type: ProteinReference
xref: uniprot Q9C0W7 898
xref: PTHR22780:SF4
organism: Schizosaccharomyces pombe

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF362
xref: uniprot Q7ZVF9 402
organism: Danio rerio

MLK-2
type: Protein
entity reference: MLK-2
feature: ACTIVE 84
feature: MLK 2 s39 a53 rs1
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Caspase-3
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot P42574 1149
organism: Homo sapiens

uniprot Q5E963 1055
type: UnificationXref
id: Q5E963
db: uniprot

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot F6XLX5 686
organism: Monodelphis domestica

Fos proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot E2QYK5 422
organism: Canis lupus familiaris

uniprot A8XF10 449
type: UnificationXref
id: A8XF10
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot F6UA63 279
organism: Macaca mulatta

Glutamate ionotropic receptor kainate type subunit 1
type: ProteinReference
xref: uniprot A0A1D5PHB3 617
xref: PTHR18966:SF36
organism: Gallus gallus

uniprot P07142 1193
type: UnificationXref
id: P07142
db: uniprot

uniprot O43426 1184
type: UnificationXref
id: O43426
db: uniprot

Transcription factor Sp1
type: ProteinReference
xref: uniprot P08047 1124
organism: Homo sapiens

Optineurin
type: ProteinReference
xref: uniprot K7CAG5 1138
organism: Pan troglodytes

Actin, alpha 2, smooth muscle, aorta
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot F2Z4N0 269
organism: Canis lupus familiaris

uniprot A0A1D5R2U8 618
type: UnificationXref
id: A0A1D5R2U8
db: uniprot

Actin, gamma 2, smooth muscle, enteric
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot F2Z4N8 271
organism: Canis lupus familiaris

PTHR12346:SF0
type: RelationshipXref
id: PTHR12346:SF0
db: PANTHER Family
relationship type: By Homology

Actin, alpha, cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot F2Z4N7 270
organism: Canis lupus familiaris

PTHR12346:SF2
type: RelationshipXref
id: PTHR12346:SF2
db: PANTHER Family
relationship type: By Homology

PTHR12346:SF1
type: RelationshipXref
id: PTHR12346:SF1
db: PANTHER Family
relationship type: By Homology

uniprot P60711 336
type: UnificationXref
id: P60711
db: uniprot

uniprot Q63170 549
type: UnificationXref
id: Q63170
db: uniprot

PTHR48013:SF11
type: RelationshipXref
id: PTHR48013:SF11
db: PANTHER Family
relationship type: By Homology

PTHR12346:SF8
type: RelationshipXref
id: PTHR12346:SF8
db: PANTHER Family
relationship type: By Homology

Rac-like GTP-binding protein ARAC3
type: ProteinReference
xref: uniprot Q38912 1277
organism: Arabidopsis thaliana

PTHR48013:SF15
type: RelationshipXref
id: PTHR48013:SF15
db: PANTHER Family
relationship type: By Homology

Protein cbp-1
type: ProteinReference
xref: PTHR13808:SF1
xref: uniprot P34545 1010
organism: Caenorhabditis elegans

PTHR48013:SF17
type: RelationshipXref
id: PTHR48013:SF17
db: PANTHER Family
relationship type: By Homology

uniprot Q99963 1181
type: UnificationXref
id: Q99963
db: uniprot

uniprot P53489 327
type: UnificationXref
id: P53489
db: uniprot

uniprot F1NKL4 472
type: UnificationXref
id: F1NKL4
db: uniprot

uniprot P12411 797
type: UnificationXref
id: P12411
db: uniprot

uniprot A9WBV5 911
type: UnificationXref
id: A9WBV5
db: uniprot

Actin alpha cardiac muscle 1b
type: ProteinReference
xref: uniprot Q9I8V1 410
xref: PTHR11937:SF184
organism: Danio rerio

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot Q9WUA6 1174
organism: Mus musculus

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot A8JH45 448
organism: Chlamydomonas reinhardtii

Htt
type: Protein
entity reference: Htt
feature: COMPLEX PARTICIPANT BINDING FEATURE s72 sa28 1567
cellular location: clathrin coat of endocytic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot P21237 596
type: UnificationXref
id: P21237
db: uniprot

uniprot F1NYB1 753
type: UnificationXref
id: F1NYB1
db: uniprot

Hip-12
type: Protein
entity reference: Hip-12
feature: COMPLEX PARTICIPANT BINDING FEATURE s80 sa34 1555
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: DnaReference
xref: PTHR48106:SF13
organism: Dictyostelium discoideum

PTHR48013:SF20
type: RelationshipXref
id: PTHR48013:SF20
db: PANTHER Family
relationship type: By Homology

Rac-like GTP-binding protein ARAC1
type: ProteinReference
xref: uniprot Q38902 1275
organism: Arabidopsis thaliana

alpha-Adaptin
type: Protein
entity reference: alpha-Adaptin
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Arfaptin-2
type: ProteinReference
xref: uniprot Q6AY65 1101
xref: PTHR12141:SF3
organism: Rattus norvegicus

Rac-like GTP-binding protein ARAC2
type: ProteinReference
xref: uniprot Q38903 1276
organism: Arabidopsis thaliana

uniprot C3Y2F5 742
type: UnificationXref
id: C3Y2F5
db: uniprot

uniprot P35280 1027
type: UnificationXref
id: P35280
db: uniprot

uniprot H3DZP3 779
type: UnificationXref
id: H3DZP3
db: uniprot

uniprot Q6TYR8 849
type: UnificationXref
id: Q6TYR8
db: uniprot

uniprot Q91XQ0 573
type: UnificationXref
id: Q91XQ0
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 233

GAPDH
type: Protein
entity reference: GAPDH
feature: COMPLEX PARTICIPANT BINDING FEATURE s60 sa17 1597
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Dynein light chain
type: ProteinReference
xref: uniprot W4Z8M4 594
xref: PTHR11886:SF35
organism: Strongylocentrotus purpuratus

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot W4Z8M3 593
organism: Strongylocentrotus purpuratus

uniprot Q58CQ2 1054
type: UnificationXref
id: Q58CQ2
db: uniprot

AGAP001573-PA
type: ProteinReference
xref: uniprot Q380U3 1274
organism: Anopheles gambiae

Dynactin subunit 1
type: ProteinReference
xref: PTHR18916:SF6
xref: uniprot H2QI59 1314
organism: Pan troglodytes

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF89
xref: uniprot C3XVM4 455
organism: Branchiostoma floridae

Protein kinase C and casein kinase substrate in neurons protein 1
type: ProteinReference
xref: PTHR23065:SF16
xref: uniprot Q9BY11 17
organism: Homo sapiens

Rac-like GTP-binding protein ARAC4
type: ProteinReference
xref: uniprot Q38919 1278
organism: Arabidopsis thaliana

Putative actin-22
type: ProteinReference
xref: uniprot Q553U6 373
xref: PTHR11937:SF421
organism: Dictyostelium discoideum

Proline dehydrogenase
type: DnaReference
organism: Pan troglodytes

Clathrin light chain B
type: ProteinReference
xref: PTHR10639:SF28
xref: uniprot P08082 664
organism: Rattus norvegicus

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q7X8A1 980
organism: Oryza sativa

Tubulin beta chain
type: ProteinReference
xref: uniprot Q6GLE7 839
xref: PTHR11588:SF61
organism: Xenopus tropicalis

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot F6Q1J4 920
organism: Macaca mulatta

Sp8 transcription factor
type: ProteinReference
xref: uniprot E1BMR6 1120
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Z8M9 1421
xref: PTHR11711:SF357
organism: Monodelphis domestica

uniprot Q5ZMQ2 384
type: UnificationXref
id: Q5ZMQ2
db: uniprot

PACSIN-1
type: Protein
entity reference: PACSIN-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s77 sa31 1589
cellular location: clathrin coat of endocytic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot P36022 521
type: UnificationXref
id: P36022
db: uniprot

uniprot Q9NWB7 1094
type: UnificationXref
id: Q9NWB7
db: uniprot

Rac family small GTPase 1a
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q7ZSZ9 1292
organism: Danio rerio

TATA-box-binding protein 1
type: ProteinReference
xref: uniprot Q8TI26 1355
xref: PTHR10126:SF42
organism: Methanosarcina acetivorans

Calpain small subunit 1
type: ProteinReference
xref: PTHR46735:SF3
xref: uniprot P13135 151
organism: Bos taurus

Uncharacterized protein
type: DnaReference
xref: PTHR44054:SF1
organism: Bos taurus

Rho-related GTP-binding protein RhoJ
type: ProteinReference
xref: PTHR24072:SF17
xref: uniprot F7GWQ8 1234
organism: Macaca mulatta

uniprot H2QJN7 1433
type: UnificationXref
id: H2QJN7
db: uniprot

uniprot P32085 1341
type: UnificationXref
id: P32085
db: uniprot

uniprot H2R1S6 1112
type: UnificationXref
id: H2R1S6
db: uniprot

uniprot A8BSW7 1381
type: UnificationXref
id: A8BSW7
db: uniprot

Calpain 3
type: ProteinReference
xref: PTHR10183:SF329
xref: uniprot A6QP82 116
organism: Bos taurus

ncbitaxon 185431 370
type: UnificationXref
id: 185431
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Apaf_1-RIGHT__Apaf_1-_r30
controller: Cytochrome c

Calpain 12
type: ProteinReference
xref: uniprot D3ZJZ8 118
xref: PTHR10183:SF280
organism: Rattus norvegicus

Glutamate receptor, ionotropic, kainate 1
type: ProteinReference
xref: PTHR18966:SF36
xref: uniprot F7BDN8 640
organism: Xenopus tropicalis

uniprot F6VUB3 483
type: UnificationXref
id: F6VUB3
db: uniprot

ncbitaxon 284811 397
type: UnificationXref
id: 284811
db: ncbitaxon

Calpain-10 isoform a
type: ProteinReference
xref: uniprot H9FPA8 137
xref: PTHR10183:SF30
organism: Macaca mulatta

uniprot Q6K5G8 976
type: UnificationXref
id: Q6K5G8
db: uniprot

AGAP001676-PA
type: ProteinReference
xref: PTHR11937:SF397
xref: uniprot Q7PXZ8 399
organism: Anopheles gambiae

alpha-Adaptin
type: Protein
entity reference: alpha-Adaptin
feature: COMPLEX PARTICIPANT BINDING FEATURE s85 sa39 1627
cellular location: clathrin coat of endocytic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot F6SFW8 127
type: UnificationXref
id: F6SFW8
db: uniprot

AGAP001672-PA
type: ProteinReference
xref: uniprot Q7PXZ5 557
xref: PTHR10676:SF36
organism: Anopheles gambiae

Histone acetyltransferase p300
type: ProteinReference
xref: PTHR13808:SF29
xref: uniprot F6T7D0 1006
organism: Macaca mulatta

Rac-like GTP-binding protein 1
type: ProteinReference
xref: uniprot Q9SSX0 1302
organism: Oryza sativa

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q57930 1351
organism: Methanocaldococcus jannaschii

uniprot F7ANC6 639
type: UnificationXref
id: F7ANC6
db: uniprot

Calpain-11
type: ProteinReference
xref: uniprot Q9UMQ6 176
xref: PTHR10183:SF322
organism: Homo sapiens

uniprot P45985 615
type: UnificationXref
id: P45985
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot B7PA92 737
xref: PTHR11588:SF9
organism: Ixodes scapularis

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF314
xref: uniprot B7PA95 738
organism: Ixodes scapularis

Cytoplasmic dynein 1 intermediate chain 2
type: ProteinReference
xref: uniprot Q0III3 530
xref: PTHR12442:SF37
organism: Bos taurus

ncbitaxon 5664 413
type: UnificationXref
id: 5664
db: ncbitaxon

uniprot Q9D7J7 170
type: UnificationXref
id: Q9D7J7
db: uniprot

Putative actin-23
type: ProteinReference
xref: PTHR11937:SF154
xref: uniprot Q55EU6 374
organism: Dictyostelium discoideum

Tubulin beta chain
type: ProteinReference
xref: uniprot F2Z4P1 755
xref: PTHR11588:SF43
organism: Canis lupus familiaris

uniprot F7GEK1 1166
type: UnificationXref
id: F7GEK1
db: uniprot

uniprot Q5BL41 377
type: UnificationXref
id: Q5BL41
db: uniprot

uniprot P61160 338
type: UnificationXref
id: P61160
db: uniprot

PolyQ Htt s32 a45 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

RHOJ isoform 2
type: ProteinReference
xref: PTHR24072:SF17
xref: uniprot H2Q8F7 1238
organism: Pan troglodytes

Tubulin beta chain
type: ProteinReference
xref: uniprot C3YMF1 744
organism: Branchiostoma floridae

Histone acetyltransferase p300
type: ProteinReference
xref: PTHR13808:SF29
xref: uniprot B2RWS6 1001
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F6R8N3 1163
organism: Macaca mulatta

Actin-like protein 53D
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P45891 323
organism: Drosophila melanogaster

Dynein cytoplasmic 1 intermediate chain 2
type: ProteinReference
xref: PTHR12442:SF37
xref: uniprot F6PI02 478
organism: Ornithorhynchus anatinus

Protein kinase C and casein kinase substrate in neurons protein 1
type: ProteinReference
xref: uniprot Q9Z0W5 19
xref: PTHR23065:SF16
organism: Rattus norvegicus

uniprot K7CGY0 1240
type: UnificationXref
id: K7CGY0
db: uniprot

alpha-Adaptin
type: ProteinReference
xref: P00782
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: alpha-Adaptin Synonym: Synonym not specified Accession: P00782
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC._alpha_-Adaptin
member entity reference: AP-2 complex subunit alpha-2
member entity reference: AP-2 complex subunit alpha-1
member entity reference: AP-2 complex subunit alpha
member entity reference: Adaptor related protein complex 2 subunit alpha 2

uniprot F6X9N6 1038
type: UnificationXref
id: F6X9N6
db: uniprot

Bax
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

uniprot Q6NW90 841
type: UnificationXref
id: Q6NW90
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QV13 110
xref: PTHR10183:SF268
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR12442:SF37
xref: uniprot A0A1D5Q9P4 436
organism: Macaca mulatta

beta-Tubulin
type: Protein
entity reference: beta-Tubulin
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot F6TSX6 921
xref: PTHR10836:SF111
organism: Macaca mulatta

Tubulin beta chain
type: ProteinReference
xref: uniprot A7S8I3 726
organism: Nematostella vectensis

ADP ribosylation factor 6
type: ProteinReference
xref: PTHR11711:SF379
xref: uniprot G3N3N1 1428
organism: Bos taurus

uniprot A8JH45 448
type: UnificationXref
id: A8JH45
db: uniprot

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 956

uniprot A0A2I3TBB9 1134
type: UnificationXref
id: A0A2I3TBB9
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot W4X9L8 867
xref: PTHR11588:SF9
organism: Strongylocentrotus purpuratus

PTHR44154:SF1
type: RelationshipXref
id: PTHR44154:SF1
db: PANTHER Family
relationship type: By Homology

uniprot P62736 340
type: UnificationXref
id: P62736
db: uniprot

Caspase 6
type: ProteinReference
xref: uniprot F1NEL6 1116
xref: PTHR10454:SF206
organism: Gallus gallus

uniprot P02574 304
type: UnificationXref
id: P02574
db: uniprot

Quinone oxidoreductase
type: DnaReference
xref: PTHR43677:SF4
organism: Gloeobacter violaceus

uniprot P78958 960
type: UnificationXref
id: P78958
db: uniprot

…
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 8.0

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot F6Z879 1324
organism: Monodelphis domestica

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q28HJ8 966
xref: PTHR10836:SF111
organism: Xenopus tropicalis

ADP-ribosylation factor-like protein 4A
type: ProteinReference
xref: PTHR11711:SF139
xref: uniprot P40617 1452
organism: Homo sapiens

ADP-ribosylation factor-like protein 1
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot P40616 1451
organism: Homo sapiens

Synaptojanin
type: ProteinReference
xref: uniprot G5ECL2 1183
organism: Caenorhabditis elegans

Huntingtin
type: DnaReference
xref: PTHR10170:SF10
organism: Canis lupus familiaris

STATE_TRANSITION_LEFT__p53-RIGHT__p53-_r39
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 1706
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 1705
left: p53
interaction type: STATE_TRANSITION
right: p53

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q5ADM7 970
organism: Candida albicans

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot P27726 955
organism: Pseudomonas aeruginosa

uniprot A0A2J8KC38 442
type: UnificationXref
id: A0A2J8KC38
db: uniprot

uniprot H2Q894 1431
type: UnificationXref
id: H2Q894
db: uniprot

uniprot Q11002 157
type: UnificationXref
id: Q11002
db: uniprot

uniprot J9NWP6 1440
type: UnificationXref
id: J9NWP6
db: uniprot

PTHR11447:SF8
type: RelationshipXref
id: PTHR11447:SF8
db: PANTHER Family
relationship type: By Homology

uniprot Q9GZS0 579
type: UnificationXref
id: Q9GZS0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot A0A1D5QAU9 1320
organism: Macaca mulatta

PTHR11447:SF6
type: RelationshipXref
id: PTHR11447:SF6
db: PANTHER Family
relationship type: By Homology

uniprot P07830 308
type: UnificationXref
id: P07830
db: uniprot

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot A0A167VDT2 668
organism: Gallus gallus

ncbitaxon 418459 256
type: UnificationXref
id: 418459
db: ncbitaxon

Intraflagellar transport 57
type: ProteinReference
xref: uniprot D4A1V1 1084
xref: PTHR16011:SF0
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r22 1742
type: Stoichiometry
physical entity: Protein fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 1741
type: Stoichiometry
physical entity: Htt
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 1743
type: Stoichiometry
physical entity: Truncated Htt
stoichiometric coefficient: 1.0

Dynein heavy chain, cytoplasmic
type: ProteinReference
xref: PTHR10676:SF314
xref: uniprot O13290 512
organism: Schizosaccharomyces pombe

uniprot P17655 153
type: UnificationXref
id: P17655
db: uniprot

Dynein light chain, cytoplasmic
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot O94111 517
organism: Emericella nidulans

uniprot H2QNY5 695
type: UnificationXref
id: H2QNY5
db: uniprot

uniprot H2QUY9 508
type: UnificationXref
id: H2QUY9
db: uniprot

uniprot O08688 140
type: UnificationXref
id: O08688
db: uniprot

Glutamate ionotropic receptor NMDA type subunit 1
type: ProteinReference
evidence: Evidence 22
xref: uniprot G3N3K3 46
xref: PTHR18966:SF377
organism: Bos taurus

uniprot E3KPL3 748
type: UnificationXref
id: E3KPL3
db: uniprot

uniprot F0ZQR3 1223
type: UnificationXref
id: F0ZQR3
db: uniprot

STATE_TRANSITION_LEFT__PolyQ_Htt-RIGHT__PolyQ_Htt-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 1682
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 1683
left: PolyQ Htt
interaction type: STATE_TRANSITION
right: PolyQ Htt

PolyQ Htt s9 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 8.0

Glutamate receptor ionotropic, kainate 1
type: ProteinReference
xref: uniprot Q60934 656
xref: PTHR18966:SF36
organism: Mus musculus

uniprot Q7QGN5 165
type: UnificationXref
id: Q7QGN5
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Htt-RIGHT__Protein_fragment-_Truncated_Htt-_r22
controller: Calpain

PTHR11588:SF404
type: RelationshipXref
id: PTHR11588:SF404
db: PANTHER Family
relationship type: By Homology

Tubulin beta-2B chain
type: ProteinReference
xref: PTHR11588:SF330
xref: uniprot Q3KRE8 824
organism: Rattus norvegicus

PTHR13992:SF21
type: RelationshipXref
id: PTHR13992:SF21
db: PANTHER Family
relationship type: By Homology

TATA-box binding protein
type: ProteinReference
xref: PTHR10126:SF20
xref: uniprot F1PQA5 1329
organism: Canis lupus familiaris

Synaptic vesicle membrane protein VAT-1 homolog
type: DnaReference
xref: PTHR44054:SF1
organism: Mus musculus

uniprot F6SDC9 276
type: UnificationXref
id: F6SDC9
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot F7DCY3 768
xref: PTHR11588:SF55
organism: Macaca mulatta

Dynein complex
type: ProteinReference
xref: P00774
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Dynein_br_complex
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dynein heavy chain at 16F
member entity reference: Uncharacterized protein
member entity reference: Dynein light chain
member entity reference: Dynein cytoplasmic 1 light intermediate chain 2
member entity reference: Dynein heavy chain, cytoplasmic
member entity reference: Dynein light chain 1, cytoplasmic
member entity reference: Cytoplasmic dynein heavy chain 2
member entity reference: Dynein cytoplasmic 1 intermediate chain 2
member entity reference: Dynein heavy chain 8, axonemal
member entity reference: Dynein axonemal heavy chain 3
member entity reference: Dynein axonemal heavy chain 7
member entity reference: Putative dynein heavy chain, cytosolic
member entity reference: AGAP003226-PA (Fragment)
member entity reference: Dynein heavy chain 7, axonemal
member entity reference: Dynein light chain 2, cytoplasmic
member entity reference: Dynein cytoplasmic 1 heavy chain 1
member entity reference: AGAP003271-PA
member entity reference: Dynein cytoplasmic 1 light intermediate chain 1
member entity reference: Dynein axonemal heavy chain 5
member entity reference: Dynein light chain 4, axonemal
member entity reference: Cytoplasmic dynein 1 light intermediate chain 2
member entity reference: Dynein light intermediate chain, isoform A
member entity reference: AGAP000723-PA
member entity reference: DYNC1H1 isoform 2
member entity reference: Male fertility factor kl3
member entity reference: DYNC1LI1 isoform 1
member entity reference: Dynein heavy chain 3, axonemal
member entity reference: AGAP009568-PA (Fragment)
member entity reference: Dynein heavy chain at 62B
member entity reference: Cytoplasmic dynein 1 light intermediate chain 1

uniprot P68033 352
type: UnificationXref
id: P68033
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase 2
type: ProteinReference
xref: uniprot P80505 961
organism: Synechocystis

Brain-derived neurotrophic factor
type: DnaReference
xref: PTHR11589:SF3
organism: Pan troglodytes

Caspase 8, apoptosis-related cysteine peptidase
type: ProteinReference
xref: uniprot F1QLH0 1104
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F7AGW3 638
xref: PTHR18966:SF36
organism: Macaca mulatta

uniprot P78774 1050
type: UnificationXref
id: P78774
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Fos_protein-_c_Jun-RIGHT__Complex__Fos_protein_c_Jun_-_r33
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1716
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1717
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1718
left: c-Jun
left: Fos protein
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Fos protein/c-Jun)

uniprot E7F101 32
type: UnificationXref
id: E7F101
db: uniprot

TBP
type: ProteinReference
xref: P00779
standard name: Tata binding protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.TBP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: TATA-box-binding protein 1
member entity reference: TATA-box-binding protein
member entity reference: TATA-box-binding protein E
member entity reference: TATA-box-binding protein 2
member entity reference: Protein CBR-TBP-1
member entity reference: Uncharacterized protein
member entity reference: TATA-box-binding protein 3
member entity reference: TATA-box-binding protein B
member entity reference: TATA-box-binding protein F
member entity reference: AGAP010958-PA
member entity reference: Os12g0580300 protein
member entity reference: TATA-box binding protein
member entity reference: TBP-related factor

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF20
xref: uniprot O13270 1332
organism: Gallus gallus

Rho family GTPase
type: ProteinReference
xref: uniprot C4M5Q7 1217
organism: Entamoeba histolytica

uniprot P61161 339
type: UnificationXref
id: P61161
db: uniprot

uniprot B8BQU2 913
type: UnificationXref
id: B8BQU2
db: uniprot

CBP
type: Protein
entity reference: CBP
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa7 1615
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q91VA3 167
type: UnificationXref
id: Q91VA3
db: uniprot

uniprot E2QSF4 745
type: UnificationXref
id: E2QSF4
db: uniprot

uniprot Q0IPW3 366
type: UnificationXref
id: Q0IPW3
db: uniprot

uniprot P84096 1262
type: UnificationXref
id: P84096
db: uniprot

Complex (Htt/Hip-1)
type: Complex
component stoichiometry: Hip 1 s64 sa21 STOICHIOMETRY ID COMPLEX
component stoichiometry: Htt s63 sa20 STOICHIOMETRY ID COMPLEX
component: Htt
component: Hip-1
feature: COMPLEX BINDING FEATURE s104 a135 1648
feature: COMPLEX BINDING FEATURE s104 a135 1650
cellular location: synapse

uniprot F6XLX5 686
type: UnificationXref
id: F6XLX5
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q75D00 396
organism: Ashbya gossypii

Putative oxidoreductase
type: DnaReference
organism: Streptomyces coelicolor

uniprot F0ZI20 752
type: UnificationXref
id: F0ZI20
db: uniprot

uniprot Q17031 1269
type: UnificationXref
id: Q17031
db: uniprot

uniprot O00291 432
type: UnificationXref
id: O00291
db: uniprot

ncbitaxon 284591 91
type: UnificationXref
id: 284591
db: ncbitaxon

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot F7A5M9 687
organism: Xenopus tropicalis

uniprot F1PGY9 476
type: UnificationXref
id: F1PGY9
db: uniprot

PolyQ Htt
type: Protein
entity reference: PolyQ Htt
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa8 1617
feature: PolyQ Htt s13 sa8 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 49
xref: uniprot Q05586 67
xref: PTHR18966:SF377
organism: Homo sapiens

Ras homolog family member J
type: ProteinReference
xref: PTHR24072:SF17
xref: uniprot F1PYF1 1226
organism: Canis lupus familiaris

ncbitaxon 83332 963
type: UnificationXref
id: 83332
db: ncbitaxon

Batrachochytrium dendrobatidis
type: BioSource
xref: ncbitaxon 684364 757

Apoptotic protease-activating factor 1
type: ProteinReference
xref: uniprot O88879 1114
xref: PTHR22845:SF5
organism: Mus musculus

Actin
type: Complex
component stoichiometry: Actin s88 sa41 STOICHIOMETRY ID COMPLEX
component: Actin
feature: COMPLEX PARTICIPANT BINDING FEATURE s88 sa41 1631
cellular location: clathrin coat of endocytic vesicle

Actin
type: Complex
component stoichiometry: Actin s139 a177 STOICHIOMETRY ID COMPLEX
component: Actin
cellular location: synapse

uniprot Q9M9N1 1526
type: UnificationXref
id: Q9M9N1
db: uniprot

Clathrin light chain
type: ProteinReference
xref: PTHR10639:SF1
xref: uniprot H2QX95 660
organism: Pan troglodytes

uniprot A0A1L1RMP9 1376
type: UnificationXref
id: A0A1L1RMP9
db: uniprot

uniprot A0A2I3RRL1 438
type: UnificationXref
id: A0A2I3RRL1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF446
xref: uniprot F6R9F4 273
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F6A6 1087
xref: PTHR16011:SF0
organism: Macaca mulatta

Disks large homolog 4
type: ProteinReference
xref: uniprot P78352 1079
organism: Homo sapiens

Actin, indirect flight muscle
type: ProteinReference
xref: PTHR11937:SF397
xref: uniprot P83967 362
organism: Drosophila melanogaster

uniprot Q6DIV3 1501
type: UnificationXref
id: Q6DIV3
db: uniprot

uniprot B7Q717 739
type: UnificationXref
id: B7Q717
db: uniprot

uniprot A5PJP8 1321
type: UnificationXref
id: A5PJP8
db: uniprot

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot Q7PXC4 556
organism: Anopheles gambiae

uniprot F6YZ56 93
type: UnificationXref
id: F6YZ56
db: uniprot

uniprot B3RKR4 228
type: UnificationXref
id: B3RKR4
db: uniprot

uniprot Q92793 1014
type: UnificationXref
id: Q92793
db: uniprot

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P0CY33 1242
organism: Candida albicans

uniprot P22756 644
type: UnificationXref
id: P22756
db: uniprot

uniprot F1MCL3 34
type: UnificationXref
id: F1MCL3
db: uniprot

uniprot Q9BUF5 860
type: UnificationXref
id: Q9BUF5
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot Q9WTU6 608
xref: PTHR24055:SF172
organism: Mus musculus

uniprot O88501 147
type: UnificationXref
id: O88501
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot Q0UMY5 1483
organism: Phaeosphaeria nodorum

uniprot F6RBZ7 1227
type: UnificationXref
id: F6RBZ7
db: uniprot

Nuclear receptor corepressor 1
type: ProteinReference
xref: uniprot Q60974 1371
xref: PTHR13992:SF5
organism: Mus musculus

GAPDH s60 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GAPDH
stoichiometric coefficient: 1.0

PolyQ HTT
type: DnaRegion
entity reference: Polyglutamine expanded mutant huntingtin
cellular location: synapse
comment: SPECIES_TYPE=GENE

CYC1 isoform 2
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot H2QWV8 1190
organism: Pan troglodytes

Tumor protein 63
type: ProteinReference
xref: uniprot O88898 698
xref: PTHR11447:SF8
organism: Mus musculus

ncbitaxon 178306 1360
type: UnificationXref
id: 178306
db: ncbitaxon

uniprot H2QWV8 1190
type: UnificationXref
id: H2QWV8
db: uniprot

uniprot C3XVM4 455
type: UnificationXref
id: C3XVM4
db: uniprot

uniprot Q3ZCL5 1100
type: UnificationXref
id: Q3ZCL5
db: uniprot

uniprot A8XSF1 731
type: UnificationXref
id: A8XSF1
db: uniprot

Kainate receptor
type: Protein
entity reference: Kainate receptor
feature: ACTIVE 84
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

FBJ murine osteosarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot F7EI91 424
organism: Xenopus tropicalis

actin, muscle-like
type: ProteinReference
xref: uniprot A0A1W2WEN5 188
organism: Ciona intestinalis

uniprot A7SEB1 207
type: UnificationXref
id: A7SEB1
db: uniprot

ADP ribosylation factor 5
type: ProteinReference
xref: uniprot Q6P7Z6 1508
xref: PTHR11711:SF357
organism: Xenopus tropicalis

PTHR11711:SF119
type: RelationshipXref
id: PTHR11711:SF119
db: PANTHER Family
relationship type: By Homology

Actin, alpha, cardiac muscle 1a
type: ProteinReference
xref: uniprot F1RCB6 268
xref: PTHR11937:SF150
organism: Danio rerio

CREB binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot K7DBC8 1009
organism: Pan troglodytes

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot A8XW67 450
organism: Caenorhabditis briggsae

uniprot Q38912 1277
type: UnificationXref
id: Q38912
db: uniprot

Dynein light chain
type: ProteinReference
xref: uniprot H2R986 509
xref: PTHR11886:SF75
organism: Pan troglodytes

AGAP003226-PA (Fragment)
type: ProteinReference
xref: PTHR10676:SF339
xref: uniprot Q7QBD1 560
organism: Anopheles gambiae

PTHR11711:SF110
type: RelationshipXref
id: PTHR11711:SF110
db: PANTHER Family
relationship type: By Homology

Nuclear receptor corepressor 2
type: ProteinReference
xref: PTHR13992:SF21
xref: uniprot Q9WU42 1372
organism: Mus musculus

uniprot Q29537 704
type: UnificationXref
id: Q29537
db: uniprot

PUMA
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

Complex (Fos protein/c-Jun)
type: Complex
component stoichiometry: Fos protein s114 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: c Jun s115 sa6 STOICHIOMETRY ID COMPLEX
component: c-Jun
component: Fos protein
feature: COMPLEX BINDING FEATURE s50 a67 1570
feature: COMPLEX BINDING FEATURE s50 a67 1568
cellular location: synapse

uniprot O43237 514
type: UnificationXref
id: O43237
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HSF8 131
xref: PTHR10183:SF280
organism: Macaca mulatta

uniprot Q28HJ8 966
type: UnificationXref
id: Q28HJ8
db: uniprot

Rho family GTPase
type: ProteinReference
xref: uniprot C4M5Z7 1219
organism: Entamoeba histolytica

uniprot Q5MJ86 973
type: UnificationXref
id: Q5MJ86
db: uniprot

uniprot A2FNQ3 902
type: UnificationXref
id: A2FNQ3
db: uniprot

PTHR12141:SF3
type: RelationshipXref
id: PTHR12141:SF3
db: PANTHER Family
relationship type: By Homology

SEK-1
type: ProteinReference
xref: P00792
standard name: Stress signalling kinase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Stress signalling kinase 1 Synonym: Synonym not specified Accession: P00792
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.SEK-1
member entity reference: Dual specificity mitogen-activated protein kinase kinase sek-1
member entity reference: Dual specificity mitogen-activated protein kinase kinase 4
member entity reference: Mitogen-activated protein kinase kinase 4

Cytochrome c1, putative
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot B7P8B3 1186
organism: Ixodes scapularis

PolyQ Htt s13 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
evidence: Evidence 25
evidence: Evidence 22
xref: PTHR18966:SF382
xref: uniprot F6PGX6 38
organism: Monodelphis domestica

uniprot Q57930 1351
type: UnificationXref
id: Q57930
db: uniprot

uniprot F7FB74 641
type: UnificationXref
id: F7FB74
db: uniprot

uniprot F6RCU6 1164
type: UnificationXref
id: F6RCU6
db: uniprot

uniprot P42264 648
type: UnificationXref
id: P42264
db: uniprot

Os10g0561100 protein
type: DnaReference
organism: Oryza sativa

PTHR10126:SF42
type: RelationshipXref
id: PTHR10126:SF42
db: PANTHER Family
relationship type: By Homology

PTHR10126:SF41
type: RelationshipXref
id: PTHR10126:SF41
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR10183:SF322
xref: uniprot F6SFW8 127
organism: Macaca mulatta

PTHR11711:SF137
type: RelationshipXref
id: PTHR11711:SF137
db: PANTHER Family
relationship type: By Homology

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 306

uniprot O77627 1128
type: UnificationXref
id: O77627
db: uniprot

Glutamate ionotropic receptor NMDA type subunit 1
type: ProteinReference
evidence: Evidence 22
xref: uniprot F7CS79 43
xref: PTHR18966:SF377
organism: Xenopus tropicalis

uniprot A8WQT0 1182
type: UnificationXref
id: A8WQT0
db: uniprot

PTHR11711:SF139
type: RelationshipXref
id: PTHR11711:SF139
db: PANTHER Family
relationship type: By Homology

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot A8WQL1 909
organism: Caenorhabditis briggsae

PTHR23119:SF33
type: RelationshipXref
id: PTHR23119:SF33
db: PANTHER Family
relationship type: By Homology

Synaptic vesicle membrane protein VAT-1 homolog
type: DnaReference
xref: PTHR44054:SF1
organism: Homo sapiens

Brain-derived neurotrophic factor
type: ProteinReference
xref: uniprot P25429 598
xref: PTHR11589:SF3
organism: Gallus gallus

uniprot A0A3Q2U4X3 1155
type: UnificationXref
id: A0A3Q2U4X3
db: uniprot

GAPDH s62 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GAPDH
stoichiometric coefficient: 1.0

ncbitaxon 214684 380
type: UnificationXref
id: 214684
db: ncbitaxon

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 370

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q8RFN9 984
organism: Fusobacterium nucleatum

Predicted protein
type: ProteinReference
xref: uniprot A9V847 1389
xref: PTHR11711:SF30
organism: Monosiga brevicollis

Actin, alpha sarcomeric/skeletal
type: ProteinReference
xref: PTHR11937:SF240
xref: uniprot Q6P8G3 393
organism: Xenopus tropicalis

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: PTHR10836:SF111
xref: uniprot P16858 945
organism: Mus musculus

uniprot F6PWI8 479
type: UnificationXref
id: F6PWI8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10183:SF329
xref: uniprot A0A1D5QLX3 109
organism: Macaca mulatta

uniprot Q7SXW6 400
type: UnificationXref
id: Q7SXW6
db: uniprot

ADP-ribosylation factor 3b
type: ProteinReference
xref: uniprot Q78AP9 1510
xref: PTHR11711:SF316
organism: Danio rerio

MLK 2 s23 a31 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF70
xref: uniprot Q8VZW5 570
organism: Arabidopsis thaliana

ADP ribosylation factor-like GTPase 1
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot Q5BJ82 1499
organism: Xenopus tropicalis

uniprot Q38919 1278
type: UnificationXref
id: Q38919
db: uniprot

AP-2 complex subunit alpha
type: ProteinReference
xref: uniprot A0A3Q1LVF9 879
xref: PTHR22780:SF33
organism: Bos taurus

PTHR10126:SF20
type: RelationshipXref
id: PTHR10126:SF20
db: PANTHER Family
relationship type: By Homology

uniprot Q9CWF2 862
type: UnificationXref
id: Q9CWF2
db: uniprot

uniprot F6RRA8 1005
type: UnificationXref
id: F6RRA8
db: uniprot

ADP-ribosylation factor 6
type: ProteinReference
xref: PTHR11711:SF379
xref: uniprot H2Q894 1431
organism: Pan troglodytes

uniprot Q9LFQ3 107
type: UnificationXref
id: Q9LFQ3
db: uniprot

Tubulin beta-2 chain
type: ProteinReference
xref: PTHR11588:SF301
xref: uniprot Q8H7U1 857
organism: Oryza sativa

Microtubule s67 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Microtubule
stoichiometric coefficient: 1.0

uniprot Q4GYY6 830
type: UnificationXref
id: Q4GYY6
db: uniprot

PARTICIPANT STOICHIOMETRY r26 1729
type: Stoichiometry
physical entity: MLK-2
stoichiometric coefficient: 1.0

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot A8BEI6 729
organism: Giardia intestinalis

PARTICIPANT STOICHIOMETRY r26 1728
type: Stoichiometry
physical entity: MLK-2
stoichiometric coefficient: 1.0

uniprot P29037 1340
type: UnificationXref
id: P29037
db: uniprot

Hip 12 s82 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Hip-12
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r29 1722
type: Stoichiometry
physical entity: Cytochrome c
stoichiometric coefficient: 1.0

PTHR46735:SF1
type: RelationshipXref
id: PTHR46735:SF1
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r29 1721
type: Stoichiometry
physical entity: Cytochrome c
stoichiometric coefficient: 1.0

uniprot Q29RQ3 537
type: UnificationXref
id: Q29RQ3
db: uniprot

PTHR46735:SF4
type: RelationshipXref
id: PTHR46735:SF4
db: PANTHER Family
relationship type: By Homology

PTHR46735:SF3
type: RelationshipXref
id: PTHR46735:SF3
db: PANTHER Family
relationship type: By Homology

uniprot Q9HVY6 1204
type: UnificationXref
id: Q9HVY6
db: uniprot

uniprot P34036 520
type: UnificationXref
id: P34036
db: uniprot

uniprot Q7ZWH4 1059
type: UnificationXref
id: Q7ZWH4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot H3FCG4 299
organism: Pristionchus pacificus

PTHR13808:SF30
type: RelationshipXref
id: PTHR13808:SF30
db: PANTHER Family
relationship type: By Homology

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 1537

uniprot F1NXP6 1103
type: UnificationXref
id: F1NXP6
db: uniprot

PTHR13808:SF34
type: RelationshipXref
id: PTHR13808:SF34
db: PANTHER Family
relationship type: By Homology

Dynein axonemal heavy chain 3
type: ProteinReference
xref: PTHR10676:SF242
xref: uniprot F1MRU4 470
organism: Bos taurus

BCL2-associated X protein
type: DnaReference
xref: PTHR11256:SF42
organism: Xenopus tropicalis

Rac-like GTP-binding protein ARAC11
type: ProteinReference
xref: uniprot P92978 1263
organism: Arabidopsis thaliana

STATE_TRANSITION
type: InteractionVocabulary

MLK-2
type: Protein
entity reference: MLK-2
feature: MLK 2 s23 a31 rs1
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

TRANSPORT
type: InteractionVocabulary

Tubulin beta chain
type: ProteinReference
xref: uniprot Q7PSI4 855
xref: PTHR11588:SF9
organism: Anopheles gambiae

uniprot Q2HJD2 654
type: UnificationXref
id: Q2HJD2
db: uniprot

uniprot Q9UMQ6 176
type: UnificationXref
id: Q9UMQ6
db: uniprot

uniprot P55213 1150
type: UnificationXref
id: P55213
db: uniprot

PTHR13808:SF28
type: RelationshipXref
id: PTHR13808:SF28
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5QV13 110
type: UnificationXref
id: A0A1D5QV13
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A7ETS6 199
organism: Sclerotinia sclerotiorum

uniprot Q7PXZ8 399
type: UnificationXref
id: Q7PXZ8
db: uniprot

PTHR13808:SF29
type: RelationshipXref
id: PTHR13808:SF29
db: PANTHER Family
relationship type: By Homology

Rac1B, RHO family GTPase
type: ProteinReference
xref: uniprot F0ZQR3 1223
organism: Dictyostelium purpureum

JNK-2
type: ProteinReference
xref: P00799
standard name: c-Jun N-terminal kinase 2
comment: ENTITY_REFERENCE_NOTES= Long Name: c-Jun N-terminal kinase 2 Synonym: Synonym not specified Accession: P00799
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.JNK-2
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 9

uniprot O15143 1044
type: UnificationXref
id: O15143
db: uniprot

MLK-2
type: Protein
entity reference: MLK-2
feature: ACTIVE 84
feature: MLK 2 s23 a32 rs1
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

ADP-ribosylation factor 4
type: ProteinReference
xref: PTHR11711:SF110
xref: uniprot Q5BJ34 1498
organism: Xenopus tropicalis

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot B0BM87 452
organism: Xenopus tropicalis

Intraflagellar transport protein 57 homolog
type: ProteinReference
xref: uniprot Q8BXG3 1092
xref: PTHR16011:SF0
organism: Mus musculus

Rho family GTPase
type: ProteinReference
xref: uniprot C4M5T0 1218
organism: Entamoeba histolytica

Cytoplasmic dynein 2 heavy chain 1
type: ProteinReference
xref: uniprot Q45VK7 541
xref: PTHR10676:SF352
organism: Mus musculus

uniprot A0A2J8JEW8 899
type: UnificationXref
id: A0A2J8JEW8
db: uniprot

Synaptic vesicle membrane protein VAT-1 homolog-like
type: DnaReference
xref: PTHR44054:SF2
organism: Mus musculus

Caspase 3, apoptosis-related cysteine peptidase a
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot B8JK21 1146
organism: Danio rerio

uniprot F1MKA9 678
type: UnificationXref
id: F1MKA9
db: uniprot

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 294

uniprot Q921Z5 1144
type: UnificationXref
id: Q921Z5
db: uniprot

uniprot B1NA68 1322
type: UnificationXref
id: B1NA68
db: uniprot

Dynein light chain
type: ProteinReference
xref: uniprot F6V553 482
xref: PTHR11886:SF91
organism: Monodelphis domestica

uniprot A0A0D1DSG8 435
type: UnificationXref
id: A0A0D1DSG8
db: uniprot

uniprot A9TBY8 1388
type: UnificationXref
id: A9TBY8
db: uniprot

CaLPain family
type: ProteinReference
xref: PTHR46143:SF1
xref: uniprot Q22143 159
organism: Caenorhabditis elegans

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot A2FNQ3 902
organism: Trichomonas vaginalis

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF477
xref: uniprot Q6NVA9 390
organism: Xenopus tropicalis

uniprot Q38902 1275
type: UnificationXref
id: Q38902
db: uniprot

uniprot P17331 948
type: UnificationXref
id: P17331
db: uniprot

PTHR13808:SF43
type: RelationshipXref
id: PTHR13808:SF43
db: PANTHER Family
relationship type: By Homology

uniprot E2RL64 466
type: UnificationXref
id: E2RL64
db: uniprot

PARTICIPANT STOICHIOMETRY r1 1693
type: Stoichiometry
physical entity: Caspase 3
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: Complex (Sp1/Htt/ TAFII130/TBP)

PARTICIPANT STOICHIOMETRY r1 1694
type: Stoichiometry
physical entity: Caspase 3
stoichiometric coefficient: 1.0

Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
type: ProteinReference
xref: uniprot Q64467 975
organism: Mus musculus

PTHR10126:SF54
type: RelationshipXref
id: PTHR10126:SF54
db: PANTHER Family
relationship type: By Homology

Ras-related protein Rac2
type: ProteinReference
xref: uniprot P48554 1254
organism: Drosophila melanogaster

Sp1
type: ProteinReference
xref: P00803
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Sp1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Sp1 transcription factor
member entity reference: Sp1, isoform F
member entity reference: Uncharacterized protein
member entity reference: Transcription factor Sp1
member entity reference: Sp8 transcription factor

PTHR10126:SF50
type: RelationshipXref
id: PTHR10126:SF50
db: PANTHER Family
relationship type: By Homology

uniprot F7BDN8 640
type: UnificationXref
id: F7BDN8
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR44054:SF2
organism: Macaca mulatta

Monosiga brevicollis
type: BioSource
xref: ncbitaxon 81824 225

PTHR12442:SF37
type: RelationshipXref
id: PTHR12442:SF37
db: PANTHER Family
relationship type: By Homology

PTHR12442:SF34
type: RelationshipXref
id: PTHR12442:SF34
db: PANTHER Family
relationship type: By Homology

Disks large homolog 4
type: ProteinReference
xref: PTHR23119:SF33
xref: uniprot Q62108 1080
organism: Mus musculus

AGAP001478-PA
type: ProteinReference
evidence: Evidence 49
xref: uniprot Q7PXM3 78
xref: PTHR18966:SF377
organism: Anopheles gambiae

uniprot Q8WXX0 571
type: UnificationXref
id: Q8WXX0
db: uniprot

PTHR11937:SF411
type: RelationshipXref
id: PTHR11937:SF411
db: PANTHER Family
relationship type: By Homology

Actin, aortic smooth muscle
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot F1P476 266
organism: Gallus gallus

PTHR11937:SF414
type: RelationshipXref
id: PTHR11937:SF414
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF410
type: RelationshipXref
id: PTHR11937:SF410
db: PANTHER Family
relationship type: By Homology

ARF
type: Protein
entity reference: ARF
feature: COMPLEX PARTICIPANT BINDING FEATURE s117 sa58 1579
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot A1ZAD3 446
type: UnificationXref
id: A1ZAD3
db: uniprot

PolyQ Htt
type: Protein
entity reference: PolyQ Htt
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa4 1575
feature: PolyQ Htt s11 sa4 rs1
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot Q9SDK0 583
organism: Oryza sativa

uniprot F6UZV8 128
type: UnificationXref
id: F6UZV8
db: uniprot

AT17867p
type: ProteinReference
xref: uniprot Q7JWS8 1291
organism: Drosophila melanogaster

uniprot O04539 100
type: UnificationXref
id: O04539
db: uniprot

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 4

Cytoplasmic dynein 1 intermediate chain 1
type: ProteinReference
xref: PTHR12442:SF34
xref: uniprot Q29RQ3 537
organism: Bos taurus

Clathrin light chain
type: ProteinReference
xref: uniprot Q9VWA1 667
xref: PTHR10639:SF7
organism: Drosophila melanogaster

PTHR11937:SF409
type: RelationshipXref
id: PTHR11937:SF409
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF408
type: RelationshipXref
id: PTHR11937:SF408
db: PANTHER Family
relationship type: By Homology

Tubulin beta chain
type: ProteinReference
xref: uniprot F4NUL6 756
xref: PTHR11588:SF9
organism: Batrachochytrium dendrobatidis

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Proline_oxidase-RIGHT__Proline_oxidase-_re68
control type: ACTIVATION
controller: p53

uniprot P9WN83 962
type: UnificationXref
id: P9WN83
db: uniprot

Caspase-3
type: ProteinReference
xref: uniprot P55213 1150
xref: PTHR10454:SF198
organism: Rattus norvegicus

Dynein light chain
type: ProteinReference
xref: uniprot Q7QII4 563
xref: PTHR11886:SF2
organism: Anopheles gambiae

Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
type: ProteinReference
xref: uniprot O14556 924
organism: Homo sapiens

uniprot Q9U0T6 1527
type: UnificationXref
id: Q9U0T6
db: uniprot

ADP-ribosylation factor 3
type: ProteinReference
xref: PTHR11711:SF322
xref: uniprot Q7QII7 1515
organism: Anopheles gambiae

uniprot P68136 357
type: UnificationXref
id: P68136
db: uniprot

VAT1 isoform 3
type: DnaReference
xref: PTHR44054:SF1
organism: Pan troglodytes

uniprot Q6ID97 1502
type: UnificationXref
id: Q6ID97
db: uniprot

uniprot E2RKW5 1366
type: UnificationXref
id: E2RKW5
db: uniprot

MAPKK4
type: Protein
entity reference: MAPKK4
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5PHB3 617
type: UnificationXref
id: A0A1D5PHB3
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__CBP-_PolyQ_Htt-RIGHT__Complex__CBP_PolyQ_Htt_-_r37
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 1711
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 1710
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 1709
left: CBP
left: PolyQ Htt
interaction type: HETERODIMER_ASSOCIATION
right: Complex (CBP/PolyQ Htt)

Tubulin beta chain
type: ProteinReference
xref: uniprot C3Y3Q1 743
organism: Branchiostoma floridae

uniprot G5EBV3 1237
type: UnificationXref
id: G5EBV3
db: uniprot

uniprot G5EAY4 1236
type: UnificationXref
id: G5EAY4
db: uniprot

ADP-ribosylation factor 1-like 1
type: ProteinReference
xref: PTHR11711:SF333
xref: uniprot Q94231 1521
organism: Caenorhabditis elegans

Dynein heavy chain 7, axonemal
type: ProteinReference
xref: PTHR10676:SF310
xref: uniprot Q63170 549
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r59 1726
type: Stoichiometry
physical entity: Protein fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 1725
type: Stoichiometry
physical entity: Pro-caspase 8
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 1727
type: Stoichiometry
physical entity: Caspase 8
stoichiometric coefficient: 1.0

uniprot P60953 1257
type: UnificationXref
id: P60953
db: uniprot

uniprot E9H3D5 1402
type: UnificationXref
id: E9H3D5
db: uniprot

TAF4 isoform 2
type: ProteinReference
xref: uniprot H2REF4 179
xref: PTHR15138:SF18
organism: Pan troglodytes

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A7S0V7 204
organism: Nematostella vectensis

uniprot B7PHY7 1214
type: UnificationXref
id: B7PHY7
db: uniprot

Mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot F1LP57 613
organism: Rattus norvegicus

Dynactin subunit 1
type: ProteinReference
xref: uniprot F6UMF1 1312
xref: PTHR18916:SF6
organism: Canis lupus familiaris

Clathrin light chain B
type: ProteinReference
xref: uniprot Q6IRU5 666
xref: PTHR10639:SF28
organism: Mus musculus

uniprot P60712 337
type: UnificationXref
id: P60712
db: uniprot

uniprot P42859 1023
type: UnificationXref
id: P42859
db: uniprot

uniprot A8X623 1185
type: UnificationXref
id: A8X623
db: uniprot

uniprot H2QV00 1041
type: UnificationXref
id: H2QV00
db: uniprot

uniprot O15399 53
type: UnificationXref
id: O15399
db: uniprot

Wiskott-Aldrich syndrome like
type: ProteinReference
xref: uniprot F7E2I0 1069
xref: PTHR23202:SF39
organism: Ornithorhynchus anatinus

Neural Wiskott-Aldrich syndrome protein
type: ProteinReference
xref: PTHR23202:SF39
xref: uniprot A0A1D5RB13 1066
organism: Macaca mulatta

Calpain-A
type: ProteinReference
xref: PTHR10183:SF396
xref: uniprot Q11002 157
organism: Drosophila melanogaster

uniprot P35436 56
type: UnificationXref
id: P35436
db: uniprot

uniprot A2AQ07 721
type: UnificationXref
id: A2AQ07
db: uniprot

uniprot Q9ESV6 989
type: UnificationXref
id: Q9ESV6
db: uniprot

uniprot F7EPS9 430
type: UnificationXref
id: F7EPS9
db: uniprot

PTHR46454:SF3
type: RelationshipXref
id: PTHR46454:SF3
db: PANTHER Family
relationship type: By Homology

PTHR46454:SF2
type: RelationshipXref
id: PTHR46454:SF2
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF453
type: RelationshipXref
id: PTHR11937:SF453
db: PANTHER Family
relationship type: By Homology

uniprot P62739 342
type: UnificationXref
id: P62739
db: uniprot

Cytochrome c1, heme protein, mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot O59680 1191
organism: Schizosaccharomyces pombe

PolyQ Htt s9 sa2 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P12841 429
type: UnificationXref
id: P12841
db: uniprot

uniprot Q16099 652
type: UnificationXref
id: Q16099
db: uniprot

Tubulin beta-5 chain
type: ProteinReference
xref: uniprot Q2KJD0 822
xref: PTHR11588:SF61
organism: Bos taurus

ncbitaxon 3218 219
type: UnificationXref
id: 3218
db: ncbitaxon

HAP1
type: Protein
entity reference: HAP1
feature: COMPLEX PARTICIPANT BINDING FEATURE s71 sa27 1565
cellular location: clathrin coat of endocytic vesicle
comment: SPECIES_TYPE=PROTEIN

PTHR11937:SF446
type: RelationshipXref
id: PTHR11937:SF446
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF445
type: RelationshipXref
id: PTHR11937:SF445
db: PANTHER Family
relationship type: By Homology

uniprot W4XKG7 869
type: UnificationXref
id: W4XKG7
db: uniprot

Ras-related protein Rab-8A
type: ProteinReference
xref: uniprot P55258 1028
organism: Mus musculus

Rac family small GTPase 3a
type: ProteinReference
xref: PTHR24072:SF301
xref: uniprot Q6DGB7 1284
organism: Danio rerio

uniprot C3Y3Q1 743
type: UnificationXref
id: C3Y3Q1
db: uniprot

Complex (CBP/PolyQ Htt)
type: Complex
component stoichiometry: PolyQ Htt s13 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: CBP s12 sa7 STOICHIOMETRY ID COMPLEX
component: CBP
component: PolyQ Htt
feature: COMPLEX BINDING FEATURE s53 a72 1614
feature: COMPLEX BINDING FEATURE s53 a72 1616
cellular location: nucleus

uniprot Q8TU94 1358
type: UnificationXref
id: Q8TU94
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot A2GA05 903
organism: Trichomonas vaginalis

PTHR11937:SF438
type: RelationshipXref
id: PTHR11937:SF438
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR11711:SF110
xref: uniprot E9HDF7 1404
organism: Daphnia pulex

uniprot Q9C0W7 898
type: UnificationXref
id: Q9C0W7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10183:SF402
xref: uniprot F1MQD1 123
organism: Bos taurus

uniprot F6PGX6 38
type: UnificationXref
id: F6PGX6
db: uniprot

uniprot P45443 523
type: UnificationXref
id: P45443
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic
type: ProteinReference
xref: uniprot Q9FX54 991
organism: Arabidopsis thaliana

uniprot Q28GG8 1345
type: UnificationXref
id: Q28GG8
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Complex__PolyQ_Htt_GAPDH_-RIGHT__Complex__PolyQ_Htt_GAPDH_-_r53

uniprot A2CG49 1532
type: UnificationXref
id: A2CG49
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF154
xref: uniprot F0ZK40 264
organism: Dictyostelium purpureum

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot F6QTB5 1035
organism: Ornithorhynchus anatinus

PTHR11937:SF430
type: RelationshipXref
id: PTHR11937:SF430
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF434
type: RelationshipXref
id: PTHR11937:SF434
db: PANTHER Family
relationship type: By Homology

uniprot Q561U6 1495
type: UnificationXref
id: Q561U6
db: uniprot

uniprot Q6P378 391
type: UnificationXref
id: Q6P378
db: uniprot

uniprot Q9SJW6 1064
type: UnificationXref
id: Q9SJW6
db: uniprot

Brain-derived neurotrophic factor
type: DnaRegionReference
member entity reference: Brain-derived neurotrophic factor
member entity reference: Brain-derived neurotrophic factor (Fragment)
xref: G01531
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.GENE.GENE.BDNF
comment: ENTITY_REFERENCE_NOTES= Long Name: Brain-derived neurotrophic factor Synonym: Synonym not specified Accession: G01531
display name: BDNF

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot B3RQ31 736
organism: Trichoplax adhaerens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G485 642
xref: PTHR18966:SF38
organism: Monodelphis domestica

MAPKK4
type: Protein
entity reference: MAPKK4
feature: ACTIVE 84
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot F7HSF8 131
type: UnificationXref
id: F7HSF8
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot F7G487 922
xref: PTHR10836:SF111
organism: Monodelphis domestica

uniprot E1BTH9 1067
type: UnificationXref
id: E1BTH9
db: uniprot

uniprot Q9ER56 172
type: UnificationXref
id: Q9ER56
db: uniprot

uniprot Q5KP06 379
type: UnificationXref
id: Q5KP06
db: uniprot

PTHR11937:SF421
type: RelationshipXref
id: PTHR11937:SF421
db: PANTHER Family
relationship type: By Homology

c-Jun
type: ProteinReference
xref: P00776
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: c-Jun Synonym: Synonym not specified Accession: P00776
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.c-Jun
member entity reference: Transcription factor AP-1
member entity reference: Jun proto-oncogene, AP-1 transcription factor subunit
member entity reference: Jun proto-oncogene

HETERODIMER_ASSOCIATION_LEFT__Hip_1-_Htt-RIGHT__Complex__Htt_Hip_1_-_r80
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 1664
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 1662
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 1663
left: Hip-1
left: Htt
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Htt/Hip-1)

uniprot P22579 103
type: UnificationXref
id: P22579
db: uniprot

uniprot C3XYC6 239
type: UnificationXref
id: C3XYC6
db: uniprot

PTHR11937:SF423
type: RelationshipXref
id: PTHR11937:SF423
db: PANTHER Family
relationship type: By Homology

uniprot P38116 1450
type: UnificationXref
id: P38116
db: uniprot

Dynein light chain
type: ProteinReference
xref: uniprot Q5BL99 543
xref: PTHR11886:SF35
organism: Danio rerio

ADP ribosylation factor 3
type: ProteinReference
xref: PTHR11711:SF316
xref: uniprot B0JZE7 1390
organism: Xenopus tropicalis

PTHR11937:SF416
type: RelationshipXref
id: PTHR11937:SF416
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3S5A4 440
type: UnificationXref
id: A0A2I3S5A4
db: uniprot

PTHR11588:SF9
type: RelationshipXref
id: PTHR11588:SF9
db: PANTHER Family
relationship type: By Homology

Microtubule
type: Protein
entity reference: Microtubule
feature: COMPLEX PARTICIPANT BINDING FEATURE s67 sa24 1559
cellular location: clathrin coat of endocytic vesicle
comment: SPECIES_TYPE=PROTEIN

Cytoplasmic FMR1-interacting protein 2
type: ProteinReference
xref: uniprot Q96F07 711
organism: Homo sapiens

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q5XJ10 974
xref: PTHR10836:SF111
organism: Danio rerio

TAFII130
type: ProteinReference
xref: P00806
standard name: TPB assoaciate factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.TAFII130
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Transcription initiation factor TFIID subunit 4
member entity reference: IP01149p
member entity reference: TAF4 isoform 2
member entity reference: TAF (TBP-associated transcription factor) family

uniprot G3N3N1 1428
type: UnificationXref
id: G3N3N1
db: uniprot

uniprot A8BV70 208
type: UnificationXref
id: A8BV70
db: uniprot

Clathrin
type: Protein
entity reference: Clathrin
feature: COMPLEX PARTICIPANT BINDING FEATURE s84 sa38 1625
cellular location: clathrin coat of endocytic vesicle
comment: SPECIES_TYPE=PROTEIN

TBP-related factor
type: ProteinReference
xref: PTHR10126:SF41
xref: uniprot Q27896 1344
organism: Drosophila melanogaster

PTHR18966:SF397
type: RelationshipXref
id: PTHR18966:SF397
db: PANTHER Family
relationship type: By Homology

uniprot F6U0K7 1111
type: UnificationXref
id: F6U0K7
db: uniprot

PARTICIPANT STOICHIOMETRY r12 1695
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot F6RLV0 1413
type: UnificationXref
id: F6RLV0
db: uniprot

Dynein cytoplasmic 1 heavy chain 1
type: ProteinReference
xref: PTHR10676:SF314
xref: uniprot F6XKW0 488
organism: Xenopus tropicalis

CYtochrome C
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q18853 1199
organism: Caenorhabditis elegans

IFT57 isoform 1
type: ProteinReference
xref: PTHR16011:SF0
xref: uniprot H2QN22 1088
organism: Pan troglodytes

Transcription initiation factor TFIID subunit 4
type: ProteinReference
xref: uniprot P47825 182
xref: PTHR15138:SF14
organism: Drosophila melanogaster

uniprot H9G1I6 1089
type: UnificationXref
id: H9G1I6
db: uniprot

Discs large MAGUK scaffold protein 4
type: ProteinReference
xref: PTHR23119:SF33
xref: uniprot F7EZ93 1076
organism: Monodelphis domestica

Disks large homolog 4
type: ProteinReference
xref: PTHR23119:SF33
xref: uniprot P31016 1078
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r12 1696
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Protein kinase C and casein kinase substrate in neurons 1
type: ProteinReference
xref: uniprot E2RGK6 10
xref: PTHR23065:SF16
organism: Canis lupus familiaris

uniprot Q861Q8 1141
type: UnificationXref
id: Q861Q8
db: uniprot

Fos protein
type: ProteinReference
xref: P00801
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Fos protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Fos protein Synonym: c-fos Accession: P00801
member entity reference: Proto-oncogene c-Fos
member entity reference: C-fos
member entity reference: FBJ murine osteosarcoma viral oncogene homolog
member entity reference: Fos proto-oncogene, AP-1 transcription factor subunit
member entity reference: Uncharacterized protein

uniprot A2G1K5 195
type: UnificationXref
id: A2G1K5
db: uniprot

uniprot F1NEL6 1116
type: UnificationXref
id: F1NEL6
db: uniprot

PTHR18966:SF385
type: RelationshipXref
id: PTHR18966:SF385
db: PANTHER Family
relationship type: By Homology

PTHR18966:SF382
type: RelationshipXref
id: PTHR18966:SF382
db: PANTHER Family
relationship type: By Homology

Glutamate ionotropic receptor NMDA type subunit 3A
type: ProteinReference
evidence: Evidence 27
evidence: Evidence 22
xref: PTHR18966:SF397
xref: uniprot E1BK87 30
organism: Bos taurus

PTHR18966:SF377
type: RelationshipXref
id: PTHR18966:SF377
db: PANTHER Family
relationship type: By Homology

uniprot P25160 1448
type: UnificationXref
id: P25160
db: uniprot

Actin-related protein 2-B
type: ProteinReference
xref: uniprot Q56A35 376
xref: PTHR11937:SF149
organism: Danio rerio

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot P63259 344
organism: Rattus norvegicus

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot P63258 343
organism: Bos taurus

Actin-87E
type: ProteinReference
xref: PTHR11937:SF397
xref: uniprot P10981 312
organism: Drosophila melanogaster

ADP-ribosylation factor-like protein 1
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot Q20758 1486
organism: Caenorhabditis elegans

Actin-3
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P0DM42 311
organism: Caenorhabditis elegans

Actin-2
type: ProteinReference
xref: uniprot P10984 313
xref: PTHR11937:SF470
organism: Caenorhabditis elegans

uniprot Q6TYR7 848
type: UnificationXref
id: Q6TYR7
db: uniprot

PSD-95
type: Protein
entity reference: PSD-95
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa3 1573
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot Q7TMB8 709
type: UnificationXref
id: Q7TMB8
db: uniprot

Sp1
type: Protein
entity reference: Sp1
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa9 1547
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PolyQ Htt
type: ProteinReference
xref: P00800
standard name: Disease-associated mutant huntingtin containing polyglutamine expansion
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.PolyQ Htt
comment: ENTITY_REFERENCE_NOTES= Long Name: Disease-associated mutant huntingtin containing polyglutamine expansion Synonym: Synonym not specified Accession: P00800
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Huntingtin
member entity reference: Uncharacterized protein

PolyQ Htt
type: Protein
entity reference: PolyQ Htt
feature: PolyQ Htt s51 a68 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Sin3A
type: ProteinReference
xref: P00771
standard name: Histone deacetylase complex subunit Sin3a
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Sin3A
comment: ENTITY_REFERENCE_NOTES=
member entity reference: YALI0D26315p
member entity reference: Uncharacterized protein
member entity reference: SIN3 transcription regulator family member B
member entity reference: SIN3 transcription regulator family member A
member entity reference: Paired amphipathic helix protein Sin3-like 4
member entity reference: Paired amphipathic helix protein Sin3-like 2
member entity reference: Paired amphipathic helix protein Sin3a
member entity reference: Transcriptional regulatory protein SIN3
member entity reference: Sin3A, isoform G
member entity reference: SIN3 homolog A, transcription regulator
member entity reference: Paired amphipathic helix protein Sin3b

Cell division control protein 42 homolog isoform 2
type: ProteinReference
xref: uniprot F6RBZ7 1227
organism: Macaca mulatta

DISSOCIATION
type: RelationshipTypeVocabulary

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot P63267 347
organism: Homo sapiens

uniprot F7F4W9 291
type: UnificationXref
id: F7F4W9
db: uniprot

Hip 1 s81 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Hip-1
stoichiometric coefficient: 1.0

Calpain small subunit 2
type: ProteinReference
xref: PTHR46735:SF4
xref: uniprot Q9D7J7 170
organism: Mus musculus

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot P63261 346
organism: Homo sapiens

Si:dkey-183j2.10
type: ProteinReference
xref: uniprot E7F5R2 630
xref: PTHR18966:SF417
organism: Danio rerio

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot P63260 345
organism: Mus musculus

ADP-ribosylation factor-interacting protein 2
type: ProteinReference
xref: PTHR12141:SF3
xref: uniprot H2Q322 1098
organism: Pan troglodytes

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: uniprot P63268 348
xref: PTHR11937:SF445
organism: Mus musculus

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: uniprot P63269 349
xref: PTHR11937:SF201
organism: Rattus norvegicus

Synaptojanin-1
type: ProteinReference
xref: uniprot O43426 1184
organism: Homo sapiens

Hippi
type: Protein
entity reference: Hippi
feature: COMPLEX PARTICIPANT BINDING FEATURE s66 sa23 1541
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot F6XKW0 488
type: UnificationXref
id: F6XKW0
db: uniprot

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot P63270 350
organism: Gallus gallus

uniprot Q7JJU6 853
type: UnificationXref
id: Q7JJU6
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot F1PT97 1033
xref: PTHR10709:SF11
organism: Canis lupus familiaris

uniprot P93738 365
type: UnificationXref
id: P93738
db: uniprot

PTHR18966:SF361
type: RelationshipXref
id: PTHR18966:SF361
db: PANTHER Family
relationship type: By Homology

Cytoplasmic dynein 1 intermediate chain 1
type: ProteinReference
xref: PTHR12442:SF34
xref: uniprot O88485 515
organism: Mus musculus

AGAP004319-PA
type: ProteinReference
xref: PTHR11447:SF16
xref: uniprot Q7QAB9 708
organism: Anopheles gambiae

Cytoplasmic dynein 1 intermediate chain 2
type: ProteinReference
xref: PTHR12442:SF37
xref: uniprot O88487 516
organism: Mus musculus

PTHR18966:SF364
type: RelationshipXref
id: PTHR18966:SF364
db: PANTHER Family
relationship type: By Homology

Bradyrhizobium diazoefficiens
type: BioSource
xref: ncbitaxon 224911 1197

uniprot Q7PQY7 1513
type: UnificationXref
id: Q7PQY7
db: uniprot

uniprot P04406 933
type: UnificationXref
id: P04406
db: uniprot

Truncated Htt
type: Protein
entity reference: Truncated Htt
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

ADP-ribosylation factor-like 1
type: ProteinReference
xref: uniprot Q6DGK1 1500
xref: PTHR11711:SF41
organism: Danio rerio

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot P20227 1337
organism: Drosophila melanogaster

uniprot A0A3Q1LVF9 879
type: UnificationXref
id: A0A3Q1LVF9
db: uniprot

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF20
xref: uniprot P20226 1336
organism: Homo sapiens

uniprot F6WX28 423
type: UnificationXref
id: F6WX28
db: uniprot

PolyQ Htt s11 sa4 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR18966:SF351
type: RelationshipXref
id: PTHR18966:SF351
db: PANTHER Family
relationship type: By Homology

ADP-ribosylation factor 4
type: ProteinReference
xref: PTHR11711:SF110
xref: uniprot H2QMU4 1434
organism: Pan troglodytes

uniprot W4YJP3 874
type: UnificationXref
id: W4YJP3
db: uniprot

ADP ribosylation factor 6
type: ProteinReference
xref: PTHR11711:SF379
xref: uniprot F6V4X2 1420
organism: Xenopus tropicalis

Dynein axonemal heavy chain 8
type: ProteinReference
xref: uniprot E1B9R5 458
xref: PTHR22878:SF61
organism: Bos taurus

uniprot O88898 698
type: UnificationXref
id: O88898
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF357
xref: uniprot Q18817 819
organism: Caenorhabditis elegans

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot P54118 959
organism: Neurospora crassa

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: BDNF

uniprot F6PFV4 684
type: UnificationXref
id: F6PFV4
db: uniprot

ncbitaxon 64091 1348
type: UnificationXref
id: 64091
db: ncbitaxon

Adaptor related protein complex 2 subunit alpha 2
type: ProteinReference
xref: uniprot H2Q2W5 884
xref: PTHR22780:SF38
organism: Pan troglodytes

MLK-2
type: ProteinReference
xref: P00764
standard name: Mixed lineage kinase 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.MLK-2
comment: ENTITY_REFERENCE_NOTES= Long Name: Mixed lineage kinase 2 Synonym: MAPKKK10 Accession: P00764
member entity reference: Mitogen-activated protein kinase kinase kinase
member entity reference: Mitogen-activated protein kinase kinase kinase 10

uniprot F1PQA5 1329
type: UnificationXref
id: F1PQA5
db: uniprot

uniprot Q7XZG0 1517
type: UnificationXref
id: Q7XZG0
db: uniprot

uniprot F6PVY4 1034
type: UnificationXref
id: F6PVY4
db: uniprot

uniprot Q8IJ63 1520
type: UnificationXref
id: Q8IJ63
db: uniprot

Actin, beta like 2
type: ProteinReference
xref: PTHR11937:SF278
xref: uniprot H2QE24 297
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot A0A3Q2U4X3 1155
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: PTHR12442:SF34
xref: uniprot F6WW23 486
organism: Macaca mulatta

uniprot Q7PWN2 1057
type: UnificationXref
id: Q7PWN2
db: uniprot

Actin-5C
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P10987 315
organism: Drosophila melanogaster

Actin-4
type: ProteinReference
xref: uniprot P10986 314
xref: PTHR11937:SF471
organism: Caenorhabditis elegans

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P10989 316
organism: Schizosaccharomyces pombe

uniprot F1PBB6 1323
type: UnificationXref
id: F1PBB6
db: uniprot

BDNF
type: Protein
entity reference: BDNF
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Dynein axonemal heavy chain 1
type: ProteinReference
xref: uniprot H2QMR3 506
xref: PTHR10676:SF358
organism: Pan troglodytes

RHOJ protein
type: ProteinReference
xref: PTHR24072:SF17
xref: uniprot A4FV20 1208
organism: Bos taurus

Dynein cytoplasmic 1 light intermediate chain 2
type: ProteinReference
xref: uniprot F1MBQ0 468
xref: PTHR12688:SF1
organism: Bos taurus

Calpain-9
type: ProteinReference
xref: uniprot Q9D805 171
xref: PTHR10183:SF385
organism: Mus musculus

PTHR15138:SF14
type: RelationshipXref
id: PTHR15138:SF14
db: PANTHER Family
relationship type: By Homology

Calpain small subunit 1
type: ProteinReference
xref: PTHR46735:SF1
xref: uniprot O88456 146
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A0A2A6CRA8 190
organism: Pristionchus pacificus

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Htt-RIGHT__Protein_fragment-_Truncated_Htt-_r22
controller: Caspase 3

PTHR15138:SF18
type: RelationshipXref
id: PTHR15138:SF18
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot W4XVG8 870
xref: PTHR11588:SF293
organism: Strongylocentrotus purpuratus

Arp2/3 complex
type: Protein
entity reference: Arp2/3 complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s241 a175 1619
feature: ACTIVE 84
cellular location: clathrin coat of endocytic vesicle
comment: SPECIES_TYPE=PROTEIN

Gene transcription
type: Pathway

PTHR12442:SF22
type: RelationshipXref
id: PTHR12442:SF22
db: PANTHER Family
relationship type: By Homology

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot W4XVG9 871
organism: Strongylocentrotus purpuratus

Dynein light chain 2, cytoplasmic
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot Q9D0M5 577
organism: Mus musculus

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s93 sa46 1545
cellular location: synapse
comment: SPECIES_TYPE=ION

Uncharacterized protein
type: ProteinReference
xref: uniprot E9GYE9 1221
organism: Daphnia pulex

uniprot J9P5N6 1441
type: UnificationXref
id: J9P5N6
db: uniprot

PARTICIPANT STOICHIOMETRY r75 1699
type: Stoichiometry
physical entity: Complex (Rac/GDP)
stoichiometric coefficient: 1.0

PolyQ Htt s5 a6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 8.0

uniprot P63270 350
type: UnificationXref
id: P63270
db: uniprot

Rac
type: ProteinReference
xref: P00775
standard name: Ras-related C3 botulinum toxin substrate
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Rac
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Rho-related GTP-binding protein RhoJ
member entity reference: Ras-related C3 botulinum toxin substrate 2
member entity reference: Rho-related protein racC
member entity reference: Uncharacterized protein
member entity reference: Rho family GTPase
member entity reference: Rho-related GTP-binding protein RhoG
member entity reference: Cell division control protein 42 homolog
member entity reference: Ras-related protein rac-2
member entity reference: Rho-related GTP-binding protein RhoQ
member entity reference: Rac-like GTP-binding protein ARAC11
member entity reference: Rac-like GTP-binding protein 6
member entity reference: Rac-like GTP-binding protein ARAC4
member entity reference: Rac-like GTP-binding protein ARAC7
member entity reference: Protein CBR-MIG-2
member entity reference: GTPase cRac1A
member entity reference: Rho-related protein racA
member entity reference: Ras-related protein ced-10
member entity reference: Protein CBR-CDC-42
member entity reference: Rho-related protein racB
member entity reference: Uncharacterized protein rac1A
member entity reference: Rac family small GTPase 3
member entity reference: Ras-related protein Rac1
member entity reference: Rac family small GTPase 3b
member entity reference: Cell division cycle 42
member entity reference: Cell division control protein 42
member entity reference: AGAP001573-PA
member entity reference: Rac family small GTPase 1
member entity reference: Ras-related C3 botulinum toxin substrate 1
member entity reference: Rac-like GTP-binding protein ARAC9
member entity reference: Rho-related protein rac1B
member entity reference: Uncharacterized protein racC
member entity reference: Ras homolog family member G
member entity reference: Cdc42 protein, putative
member entity reference: Rac-like GTP-binding protein 7
member entity reference: AT17867p
member entity reference: RHOJ isoform 2
member entity reference: Ras homolog gene family, member G (Rho G)
member entity reference: Ras-related protein Rac2
member entity reference: Rac-like GTP-binding protein 4
member entity reference: Cdc42 homolog
member entity reference: Rac-like GTP-binding protein ARAC2
member entity reference: Rac-like GTP-binding protein ARAC1
member entity reference: CD42_CHICK Cell division control protein 42 homolog (G25K GTP-binding protein)MODA
member entity reference: Rho-related protein rac1A
member entity reference: Rac1B, RHO family GTPase
member entity reference: Rac-like GTP-binding protein 5
member entity reference: Ras homolog family member J
member entity reference: Rac-like GTP-binding protein ARAC3
member entity reference: RHOJ protein
member entity reference: Rac family small GTPase 1a

uniprot E9QG65 677
type: UnificationXref
id: E9QG65
db: uniprot

ncbitaxon 1111708 958
type: UnificationXref
id: 1111708
db: ncbitaxon

Cytoplasmic dynein 1 intermediate chain 1
type: ProteinReference
xref: PTHR12442:SF34
xref: uniprot O14576 513
organism: Homo sapiens

uniprot Q8F5H7 981
type: UnificationXref
id: Q8F5H7
db: uniprot

Rac family small GTPase 1b
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q29RC5 1272
organism: Danio rerio

uniprot G7NT58 132
type: UnificationXref
id: G7NT58
db: uniprot

Beta-actin-like protein 2
type: ProteinReference
xref: uniprot Q8BFZ3 404
xref: PTHR11937:SF168
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r4 1673
type: Stoichiometry
physical entity: Complex (Htt/PolyQ Htt)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF446
xref: uniprot C3ZTX6 252
organism: Branchiostoma floridae

PARTICIPANT STOICHIOMETRY r4 1671
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 8.0

PARTICIPANT STOICHIOMETRY r4 1672
type: Stoichiometry
physical entity: Htt
stoichiometric coefficient: 1.0

ARF-Like
type: ProteinReference
xref: uniprot G5EDC6 1429
xref: PTHR45732:SF7
organism: Caenorhabditis elegans

Calpain-5
type: ProteinReference
xref: uniprot Q22036 158
xref: PTHR10183:SF379
organism: Caenorhabditis elegans

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F7GEK1 1166
organism: Monodelphis domestica

uniprot A0A1D5PLJ8 108
type: UnificationXref
id: A0A1D5PLJ8
db: uniprot

uniprot P78352 1079
type: UnificationXref
id: P78352
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF247
xref: uniprot F7CGM4 766
organism: Monodelphis domestica

GAPDH
type: Protein
entity reference: GAPDH
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Transcription factor AP-1
type: ProteinReference
xref: uniprot P18870 1132
xref: PTHR11462:SF8
organism: Gallus gallus

NMDA receptor s100 sa49 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NMDA receptor
stoichiometric coefficient: 1.0

Dynein heavy chain 7, axonemal
type: ProteinReference
xref: PTHR10676:SF310
xref: uniprot Q8WXX0 571
organism: Homo sapiens

TATA-box-binding protein
type: ProteinReference
xref: uniprot P26355 1338
xref: PTHR10126:SF42
organism: Dictyostelium discoideum

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot A0A1D5Q7H4 669
organism: Macaca mulatta

ARF s117 sa58 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ARF
stoichiometric coefficient: 1.0

Nuclear receptor co-repressor 2
type: ProteinReference
xref: PTHR13992:SF21
xref: uniprot D3ZXN9 1365
organism: Rattus norvegicus

ARF
type: ProteinReference
xref: P00786
standard name: ADP-ribosylation factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.ARF
comment: ENTITY_REFERENCE_NOTES=
member entity reference: ADP-ribosylation factor 6a
member entity reference: ADP-ribosylation factor, putative
member entity reference: AGAP011730-PA (Fragment)
member entity reference: Uncharacterized protein
member entity reference: ADP-ribosylation factor 4-like
member entity reference: ADP-ribosylation factor 1
member entity reference: ADP-ribosylation factor D1A
member entity reference: ADP-ribosylation factor-like protein 1
member entity reference: ADP-ribosylation factor 3b
member entity reference: ADP ribosylation factor-like GTPase 4C
member entity reference: ADP ribosylation factor like GTPase 4C
member entity reference: ADP ribosylation factor like GTPase 4D
member entity reference: ADP-ribosylation factor 3
member entity reference: ADP-ribosylation factor A1B
member entity reference: ADP-ribosylation factor 5
member entity reference: ADP-ribosylation factor 6
member entity reference: Os08g0248900 protein
member entity reference: ADP ribosylation factor 5
member entity reference: ADP-ribosylation factor 4
member entity reference: ADP-ribosylation factor 2
member entity reference: Predicted protein
member entity reference: ADP-ribosylation factor A1E
member entity reference: ADP ribosylation factor 6
member entity reference: ADP-ribosylation factor-like protein 4D
member entity reference: ADP ribosylation factor like GTPase 4A
member entity reference: ADP-ribosylation factor B1B
member entity reference: ADP-ribosylation factor 1-like 2
member entity reference: ADP-ribosylation factor
member entity reference: ADP-ribosylation factor D1B
member entity reference: ADP-ribosylation factor-like 4Cb
member entity reference: ADP-ribosylation factor-like protein 4C
member entity reference: ADP ribosylation factor-like GTPase 4A
member entity reference: ADP ribosylation factor-like GTPase 1

uniprot F6PNX7 1412
type: UnificationXref
id: F6PNX7
db: uniprot

Dynein light chain
type: ProteinReference
xref: uniprot F6WUZ7 485
xref: PTHR11886:SF91
organism: Monodelphis domestica

uniprot P02340 699
type: UnificationXref
id: P02340
db: uniprot

uniprot F1NU20 632
type: UnificationXref
id: F1NU20
db: uniprot

uniprot F7GQS3 497
type: UnificationXref
id: F7GQS3
db: uniprot

Htt
type: Protein
entity reference: Htt
feature: COMPLEX PARTICIPANT BINDING FEATURE s112 sa55 1645
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Sp1 s15 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Sp1
stoichiometric coefficient: 1.0

uniprot Q7PXM3 78
type: UnificationXref
id: Q7PXM3
db: uniprot

uniprot P10096 944
type: UnificationXref
id: P10096
db: uniprot

ADP-ribosylation factor 4
type: ProteinReference
xref: uniprot P18085 1446
xref: PTHR11711:SF110
organism: Homo sapiens

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 227

P00788
type: UnificationXref
id: P00788
db: PANTHER Pathway Component

P00787
type: UnificationXref
id: P00787
db: PANTHER Pathway Component

P00786
type: UnificationXref
id: P00786
db: PANTHER Pathway Component

P00785
type: UnificationXref
id: P00785
db: PANTHER Pathway Component

uniprot F1PB63 125
type: UnificationXref
id: F1PB63
db: uniprot

P00789
type: UnificationXref
id: P00789
db: PANTHER Pathway Component

P00790
type: UnificationXref
id: P00790
db: PANTHER Pathway Component

Glyceraldehyde-3-phosphate dehydrogenase 1
type: ProteinReference
xref: uniprot P78958 960
organism: Schizosaccharomyces pombe

Dynein cytoplasmic 1 light intermediate chain 1
type: ProteinReference
xref: uniprot E2RH71 464
xref: PTHR12688:SF2
organism: Canis lupus familiaris

P00794
type: UnificationXref
id: P00794
db: PANTHER Pathway Component

P00795
type: UnificationXref
id: P00795
db: PANTHER Pathway Component

P00792
type: UnificationXref
id: P00792
db: PANTHER Pathway Component

P00793
type: UnificationXref
id: P00793
db: PANTHER Pathway Component

uniprot Q499T5 161
type: UnificationXref
id: Q499T5
db: uniprot

uniprot F2Z4P1 755
type: UnificationXref
id: F2Z4P1
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Retrograde transport
controller: Complex (Microtubule/Dynein complex/ Dynactin/HAP1/ Htt)

Clathrin s84 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Clathrin
stoichiometric coefficient: 1.0

uniprot Q7ZVI7 403
type: UnificationXref
id: Q7ZVI7
db: uniprot

uniprot Q6ZHA3 1290
type: UnificationXref
id: Q6ZHA3
db: uniprot

uniprot P08047 1124
type: UnificationXref
id: P08047
db: uniprot

P00797
type: UnificationXref
id: P00797
db: PANTHER Pathway Component

P00796
type: UnificationXref
id: P00796
db: PANTHER Pathway Component

P00799
type: UnificationXref
id: P00799
db: PANTHER Pathway Component

P00798
type: UnificationXref
id: P00798
db: PANTHER Pathway Component

Tubulin beta-2B chain
type: ProteinReference
xref: uniprot Q9BVA1 861
xref: PTHR11588:SF330
organism: Homo sapiens

Cytochrome c1, heme protein, mitochondrial
type: ProteinReference
xref: uniprot P00125 1192
xref: PTHR10266:SF3
organism: Bos taurus

NMDA receptor
type: Protein
entity reference: NMDA receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s100 sa49 1603
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot H2QC23 1077
type: UnificationXref
id: H2QC23
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot F6SCP4 275
organism: Ciona intestinalis

P00769
type: UnificationXref
id: P00769
db: PANTHER Pathway Component

P00767
type: UnificationXref
id: P00767
db: PANTHER Pathway Component

P00768
type: UnificationXref
id: P00768
db: PANTHER Pathway Component

P00765
type: UnificationXref
id: P00765
db: PANTHER Pathway Component

uniprot Q2KJD0 822
type: UnificationXref
id: Q2KJD0
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q9HZK4 992
organism: Pseudomonas aeruginosa

P00766
type: UnificationXref
id: P00766
db: PANTHER Pathway Component

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 49
evidence: Evidence 58
xref: uniprot Q13224 69
xref: PTHR18966:SF382
organism: Homo sapiens

Complex (Rac/GDP)
type: Complex
component stoichiometry: GDP s93 sa46 STOICHIOMETRY ID COMPLEX
component stoichiometry: Rac s92 sa45 STOICHIOMETRY ID COMPLEX
component: Rac
component: GDP
feature: COMPLEX BINDING FEATURE s186 a258 1544
feature: COMPLEX BINDING FEATURE s186 a258 1542
cellular location: synapse

P00763
type: UnificationXref
id: P00763
db: PANTHER Pathway Component

P00764
type: UnificationXref
id: P00764
db: PANTHER Pathway Component

Rab8
type: ProteinReference
xref: P00783
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Rab8
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Ras-related protein Rab-8A
member entity reference: Ras-related protein RABA1a

Paired amphipathic helix protein Sin3a
type: ProteinReference
xref: PTHR12346:SF2
xref: uniprot F7H3V1 97
organism: Macaca mulatta

Htt s63 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Htt
stoichiometric coefficient: 1.0

uniprot P68035 354
type: UnificationXref
id: P68035
db: uniprot

uniprot P05627 1130
type: UnificationXref
id: P05627
db: uniprot

uniprot Q60823 1173
type: UnificationXref
id: Q60823
db: uniprot

P00773
type: UnificationXref
id: P00773
db: PANTHER Pathway Component

P00772
type: UnificationXref
id: P00772
db: PANTHER Pathway Component

P00771
type: UnificationXref
id: P00771
db: PANTHER Pathway Component

P00770
type: UnificationXref
id: P00770
db: PANTHER Pathway Component

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6WV79 603
xref: PTHR24055:SF172
organism: Monodelphis domestica

P00778
type: UnificationXref
id: P00778
db: PANTHER Pathway Component

PTHR19271:SF16
type: RelationshipXref
id: PTHR19271:SF16
db: PANTHER Family
relationship type: By Homology

P00779
type: UnificationXref
id: P00779
db: PANTHER Pathway Component

uniprot A2HNG1 196
type: UnificationXref
id: A2HNG1
db: uniprot

Small ARF-related GTPase
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot A8IL29 1382
organism: Chlamydomonas reinhardtii

uniprot P09207 791
type: UnificationXref
id: P09207
db: uniprot

P00774
type: UnificationXref
id: P00774
db: PANTHER Pathway Component

PTHR10266:SF11
type: RelationshipXref
id: PTHR10266:SF11
db: PANTHER Family
relationship type: By Homology

uniprot H2QE24 297
type: UnificationXref
id: H2QE24
db: uniprot

P00775
type: UnificationXref
id: P00775
db: PANTHER Pathway Component

P00776
type: UnificationXref
id: P00776
db: PANTHER Pathway Component

Tubulin beta-2B chain
type: ProteinReference
xref: uniprot Q9CWF2 862
xref: PTHR11588:SF330
organism: Mus musculus

P00777
type: UnificationXref
id: P00777
db: PANTHER Pathway Component

Transcriptional regulatory protein SIN3
type: ProteinReference
xref: PTHR12346:SF0
xref: uniprot P22579 103
organism: Saccharomyces cerevisiae

uniprot G7MRS0 12
type: UnificationXref
id: G7MRS0
db: uniprot

PTHR48106:SF13
type: RelationshipXref
id: PTHR48106:SF13
db: PANTHER Family
relationship type: By Homology

Cytoplasmic dynein 1 light intermediate chain 1
type: ProteinReference
xref: PTHR12688:SF2
xref: uniprot Q8R1Q8 566
organism: Mus musculus

uniprot P13135 151
type: UnificationXref
id: P13135
db: uniprot

P00782
type: UnificationXref
id: P00782
db: PANTHER Pathway Component

P00781
type: UnificationXref
id: P00781
db: PANTHER Pathway Component

P00784
type: UnificationXref
id: P00784
db: PANTHER Pathway Component

P00783
type: UnificationXref
id: P00783
db: PANTHER Pathway Component

uniprot Q942X6 1201
type: UnificationXref
id: Q942X6
db: uniprot

P00780
type: UnificationXref
id: P00780
db: PANTHER Pathway Component

Pro-caspase 8
type: ProteinReference
xref: P00767
standard name: Pro-Caspase8
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Pro-caspase 8 Synonym: Synonym not specified Accession: P00767
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Pro-caspase 8
member entity reference: Caspase 8, apoptosis-related cysteine peptidase
member entity reference: CASP8 isoform 11
member entity reference: Uncharacterized protein
member entity reference: Caspase-8

uniprot Q7ZUQ0 1058
type: UnificationXref
id: Q7ZUQ0
db: uniprot

uniprot Q7QF61 562
type: UnificationXref
id: Q7QF61
db: uniprot

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 49
evidence: Evidence 58
xref: uniprot Q00960 62
xref: PTHR18966:SF382
organism: Rattus norvegicus

Glutamate receptor ionotropic, NMDA 2C
type: ProteinReference
evidence: Evidence 49
evidence: Evidence 54
xref: PTHR18966:SF361
xref: uniprot Q00961 63
organism: Rattus norvegicus

uniprot Q1RMI2 1270
type: UnificationXref
id: Q1RMI2
db: uniprot

uniprot E2RG67 1397
type: UnificationXref
id: E2RG67
db: uniprot

uniprot F7G757 496
type: UnificationXref
id: F7G757
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 101

uniprot P53365 1099
type: UnificationXref
id: P53365
db: uniprot

uniprot Q5E9B5 378
type: UnificationXref
id: Q5E9B5
db: uniprot

uniprot F7EU36 289
type: UnificationXref
id: F7EU36
db: uniprot

Actin beta
type: ProteinReference
xref: uniprot F6UDX9 280
xref: PTHR11937:SF192
organism: Ornithorhynchus anatinus

Dynein light chain
type: ProteinReference
xref: uniprot F1NRI4 473
xref: PTHR11886:SF35
organism: Gallus gallus

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot F7FN64 690
organism: Macaca mulatta

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot P47809 616
organism: Mus musculus

Glutamate receptor ionotropic, NMDA 2A
type: ProteinReference
evidence: Evidence 49
evidence: Evidence 58
evidence: Evidence 54
evidence: Evidence 57
xref: uniprot Q00959 61
xref: PTHR18966:SF407
organism: Rattus norvegicus

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot A2DHT2 900
organism: Trichomonas vaginalis

PolyQ Htt s61 sa18 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q7PSI4 855
type: UnificationXref
id: Q7PSI4
db: uniprot

Caspase-8
type: ProteinReference
xref: uniprot O89110 1107
xref: PTHR10454:SF162
organism: Mus musculus

Dual specificity mitogen-activated protein kinase kinase sek-1
type: ProteinReference
xref: PTHR48013:SF11
xref: uniprot G5EDF7 614
organism: Caenorhabditis elegans

uniprot A0A286YAY2 619
type: UnificationXref
id: A0A286YAY2
db: uniprot

Trichomonas vaginalis
type: BioSource
xref: ncbitaxon 5722 194

Arp2 3 complex s241 a175 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Arp2/3 complex
stoichiometric coefficient: 1.0

uniprot F0Z796 262
type: UnificationXref
id: F0Z796
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 33

uniprot Q8BXG3 1092
type: UnificationXref
id: Q8BXG3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot A0A1D5Q7K7 187
organism: Macaca mulatta

uniprot P01100 427
type: UnificationXref
id: P01100
db: uniprot

uniprot P18870 1132
type: UnificationXref
id: P18870
db: uniprot

uniprot F4P7H8 758
type: UnificationXref
id: F4P7H8
db: uniprot

uniprot O82480 1241
type: UnificationXref
id: O82480
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23119:SF33
xref: uniprot F7D120 1075
organism: Macaca mulatta

P00762
type: UnificationXref
id: P00762
db: PANTHER Pathway Component

P00761
type: UnificationXref
id: P00761
db: PANTHER Pathway Component

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF295
xref: uniprot Q5BL39 837
organism: Xenopus tropicalis

uniprot Q7KQL5 854
type: UnificationXref
id: Q7KQL5
db: uniprot

uniprot F1MGM4 1367
type: UnificationXref
id: F1MGM4
db: uniprot

Tubulin beta-3 chain
type: ProteinReference
xref: uniprot Q9ERD7 864
xref: PTHR11588:SF43
organism: Mus musculus

uniprot Q9LE42 1018
type: UnificationXref
id: Q9LE42
db: uniprot

Protein kinase C and casein kinase substrate in neurons protein 1
type: ProteinReference
xref: PTHR23065:SF16
xref: uniprot Q61644 14
organism: Mus musculus

Caspase-8
type: ProteinReference
xref: uniprot Q14790 1108
xref: PTHR10454:SF162
organism: Homo sapiens

uniprot O45815 302
type: UnificationXref
id: O45815
db: uniprot

PolyQ Htt
type: Protein
entity reference: PolyQ Htt
feature: PolyQ Htt s32 a45 rs1
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Non-muscle actin 6.2
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot B3RX77 230
organism: Trichoplax adhaerens

PolyQ Htt s45 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 1.0

Actin (Fragment)
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A2HNG1 196
organism: Trichomonas vaginalis

PTHR11937:SF483
type: RelationshipXref
id: PTHR11937:SF483
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r75 1700
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot P34146 1248
type: UnificationXref
id: P34146
db: uniprot

ncbitaxon 367110 361
type: UnificationXref
id: 367110
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r3 1683
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 8.0

uniprot Q7SXL3 1354
type: UnificationXref
id: Q7SXL3
db: uniprot

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF37
xref: uniprot Q5BL41 377
organism: Xenopus tropicalis

uniprot Q5R1P3 74
type: UnificationXref
id: Q5R1P3
db: uniprot

PARTICIPANT STOICHIOMETRY r3 1682
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 1.0

PTHR11886:SF35
type: RelationshipXref
id: PTHR11886:SF35
db: PANTHER Family
relationship type: By Homology

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot O18840 301
organism: Canis lupus familiaris

uniprot E1BIX3 119
type: UnificationXref
id: E1BIX3
db: uniprot

Synaptic vesicle membrane protein VAT-1 homolog-like
type: DnaReference
xref: PTHR44054:SF2
organism: Homo sapiens

PTHR13992:SF5
type: RelationshipXref
id: PTHR13992:SF5
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r75 1702
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot P63269 349
type: UnificationXref
id: P63269
db: uniprot

PARTICIPANT STOICHIOMETRY r75 1701
type: Stoichiometry
physical entity: Complex (Rac/GTP)
stoichiometric coefficient: 1.0

uniprot A8Y0A3 1386
type: UnificationXref
id: A8Y0A3
db: uniprot

uniprot P34144 1246
type: UnificationXref
id: P34144
db: uniprot

Predicted protein
type: ProteinReference
xref: uniprot A7S214 1379
xref: PTHR11711:SF30
organism: Nematostella vectensis

Cytoplasmic dynein 1 intermediate chain 1
type: ProteinReference
xref: PTHR12442:SF34
xref: uniprot Q63100 548
organism: Rattus norvegicus

PTHR11886:SF70
type: RelationshipXref
id: PTHR11886:SF70
db: PANTHER Family
relationship type: By Homology

PTHR11886:SF73
type: RelationshipXref
id: PTHR11886:SF73
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF468
type: RelationshipXref
id: PTHR11937:SF468
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__Hip_1-_Hippi-RIGHT__Complex__Hip_1_Hippi_-_r58
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1730
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1732
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1731
left: Hip-1
left: Hippi
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Hip-1/Hippi)

Glutamate receptor ionotropic, kainate 5
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot Q61626 657
organism: Mus musculus

PTHR11886:SF72
type: RelationshipXref
id: PTHR11886:SF72
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF469
type: RelationshipXref
id: PTHR11937:SF469
db: PANTHER Family
relationship type: By Homology

PTHR11886:SF75
type: RelationshipXref
id: PTHR11886:SF75
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF464
type: RelationshipXref
id: PTHR11937:SF464
db: PANTHER Family
relationship type: By Homology

uniprot G5EDF7 614
type: UnificationXref
id: G5EDF7
db: uniprot

Histone acetyltransferase HAC12
type: ProteinReference
xref: uniprot Q9FWQ5 1016
xref: PTHR13808:SF28
organism: Arabidopsis thaliana

uniprot P63001 1260
type: UnificationXref
id: P63001
db: uniprot

Glutamate ionotropic receptor kainate type subunit 2
type: ProteinReference
xref: PTHR18966:SF38
xref: uniprot F6TDQ6 636
organism: Ornithorhynchus anatinus

uniprot A8Y4Q9 216
type: UnificationXref
id: A8Y4Q9
db: uniprot

uniprot P83967 362
type: UnificationXref
id: P83967
db: uniprot

uniprot A8JHR9 907
type: UnificationXref
id: A8JHR9
db: uniprot

uniprot P62332 1473
type: UnificationXref
id: P62332
db: uniprot

uniprot O17921 784
type: UnificationXref
id: O17921
db: uniprot

PTHR11886:SF62
type: RelationshipXref
id: PTHR11886:SF62
db: PANTHER Family
relationship type: By Homology

uniprot P68139 359
type: UnificationXref
id: P68139
db: uniprot

PTHR11937:SF477
type: RelationshipXref
id: PTHR11937:SF477
db: PANTHER Family
relationship type: By Homology

Tubulin beta chain
type: ProteinReference
xref: uniprot A9RQS1 733
xref: PTHR11588:SF365
organism: Physcomitrella patens

PTHR11937:SF473
type: RelationshipXref
id: PTHR11937:SF473
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF474
type: RelationshipXref
id: PTHR11937:SF474
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot C3YP58 247
xref: PTHR11937:SF468
organism: Branchiostoma floridae

PTHR11937:SF471
type: RelationshipXref
id: PTHR11937:SF471
db: PANTHER Family
relationship type: By Homology

uniprot Q8VZW5 570
type: UnificationXref
id: Q8VZW5
db: uniprot

PTHR11937:SF470
type: RelationshipXref
id: PTHR11937:SF470
db: PANTHER Family
relationship type: By Homology

beta Tubulin s168 a225 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: beta-Tubulin
stoichiometric coefficient: 2.0

uniprot A3C6D7 197
type: UnificationXref
id: A3C6D7
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q7JY07 978
organism: Drosophila melanogaster

Vesicle amine transport protein 1 homolog (T. californica)-like
type: DnaReference
xref: PTHR44054:SF2
organism: Bos taurus

Kainate receptor
type: Protein
entity reference: Kainate receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s103 sa51 1607
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR10170:SF10
xref: uniprot F6VQZ3 1021
organism: Macaca mulatta

PTHR11886:SF89
type: RelationshipXref
id: PTHR11886:SF89
db: PANTHER Family
relationship type: By Homology

uniprot A8WNL4 1384
type: UnificationXref
id: A8WNL4
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P02340 699
xref: PTHR11447:SF6
organism: Mus musculus

ncbitaxon 3055 211
type: UnificationXref
id: 3055
db: ncbitaxon

uniprot Q62108 1080
type: UnificationXref
id: Q62108
db: uniprot

Quinone oxidoreductase PIG3 isoform 1
type: DnaReference
xref: PTHR48106:SF8
organism: Macaca mulatta

uniprot E2QV23 1096
type: UnificationXref
id: E2QV23
db: uniprot

PTHR11886:SF91
type: RelationshipXref
id: PTHR11886:SF91
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__MLK_2-RIGHT__MLK_2-_r26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 1728
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 1729
left: MLK-2
interaction type: STATE_TRANSITION
right: MLK-2

uniprot Q9ESK3 173
type: UnificationXref
id: Q9ESK3
db: uniprot

HAP1
type: Protein
entity reference: HAP1
feature: COMPLEX PARTICIPANT BINDING FEATURE s113 sa56 1647
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Tubulin beta-5 chain
type: ProteinReference
xref: uniprot P69897 813
xref: PTHR11588:SF61
organism: Rattus norvegicus

PTHR11886:SF93
type: RelationshipXref
id: PTHR11886:SF93
db: PANTHER Family
relationship type: By Homology

Tubulin beta chain
type: ProteinReference
xref: uniprot P69895 812
xref: PTHR11588:SF61
organism: Macaca mulatta

Proline oxidase
type: DnaRegion
entity reference: Proline oxidase
cellular location: nucleus
comment: SPECIES_TYPE=GENE

TRUNCATION
type: InteractionVocabulary

Calpain-2 catalytic subunit
type: ProteinReference
xref: uniprot Q92178 168
xref: PTHR10183:SF268
organism: Gallus gallus

uniprot F7FRA7 1097
type: UnificationXref
id: F7FRA7
db: uniprot

SH3GL3
type: Protein
entity reference: SH3GL3
feature: COMPLEX PARTICIPANT BINDING FEATURE s74 sa30 1587
cellular location: clathrin coat of endocytic vesicle
comment: SPECIES_TYPE=PROTEIN

Dynein light chain 2, cytoplasmic
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot Q96FJ2 574
organism: Homo sapiens

Clathrin light chain B
type: ProteinReference
xref: uniprot P09497 665
xref: PTHR10639:SF28
organism: Homo sapiens

TBP
type: Protein
entity reference: TBP
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa12 1553
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F7CB79 765
type: UnificationXref
id: F7CB79
db: uniprot

Tubulin beta-5 chain
type: ProteinReference
xref: uniprot P99024 815
xref: PTHR11588:SF61
organism: Mus musculus

Glyceraldehyde-3-phosphate dehydrogenase 1
type: ProteinReference
xref: uniprot P09124 938
organism: Bacillus subtilis

AGAP003271-PA
type: ProteinReference
xref: PTHR10676:SF344
xref: uniprot Q7PTQ4 555
organism: Anopheles gambiae

ncbitaxon 5786 263
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot F1A175 265
type: UnificationXref
id: F1A175
db: uniprot

uniprot Q40665 828
type: UnificationXref
id: Q40665
db: uniprot

Os02g0805600 protein
type: DnaReference
organism: Oryza sativa

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF91
xref: uniprot Q80ZS7 564
organism: Mus musculus

uniprot F6ZCX3 763
type: UnificationXref
id: F6ZCX3
db: uniprot

uniprot Q5RJS2 1280
type: UnificationXref
id: Q5RJS2
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 263

PTHR11886:SF84
type: RelationshipXref
id: PTHR11886:SF84
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZMR2 251
organism: Branchiostoma floridae

uniprot F6WUZ7 485
type: UnificationXref
id: F6WUZ7
db: uniprot

uniprot P60710 335
type: UnificationXref
id: P60710
db: uniprot

uniprot H2Q2W5 884
type: UnificationXref
id: H2Q2W5
db: uniprot

Dynactin
type: Protein
entity reference: Dynactin
feature: COMPLEX PARTICIPANT BINDING FEATURE s69 sa26 1563
cellular location: clathrin coat of endocytic vesicle
comment: SPECIES_TYPE=PROTEIN

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot F1PDQ4 681
organism: Canis lupus familiaris

ncbitaxon 69014 1350
type: UnificationXref
id: 69014
db: ncbitaxon

Apoptosis regulator BAX
type: DnaReference
xref: PTHR11256:SF42
organism: Mus musculus

Glyceraldehyde-3-phosphate dehydrogenase 2
type: ProteinReference
xref: uniprot P17329 946
organism: Caenorhabditis elegans

Hydroxyproline dehydrogenase
type: DnaReference
organism: Mus musculus

uniprot F7GDJ8 1121
type: UnificationXref
id: F7GDJ8
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: uniprot P17325 1131
xref: PTHR11462:SF8
organism: Rattus norvegicus

Vesicle amine transport 1 like
type: DnaReference
xref: PTHR44054:SF2
organism: Canis lupus familiaris

uniprot R4GGR6 1530
type: UnificationXref
id: R4GGR6
db: uniprot

uniprot K7CDK7 1090
type: UnificationXref
id: K7CDK7
db: uniprot

SIN3 transcription regulator family member A
type: ProteinReference
xref: PTHR12346:SF2
xref: uniprot F7B0D4 94
organism: Ornithorhynchus anatinus

uniprot A8Y0F3 117
type: UnificationXref
id: A8Y0F3
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase 4
type: ProteinReference
xref: uniprot P17331 948
organism: Caenorhabditis elegans

uniprot G2HG81 1040
type: UnificationXref
id: G2HG81
db: uniprot

uniprot Q9H4E5 1299
type: UnificationXref
id: Q9H4E5
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase 3
type: ProteinReference
xref: uniprot P17330 947
organism: Caenorhabditis elegans

mitochondrion
type: CellularLocationVocabulary
xref: GO GO:0005739 3

PARTICIPANT STOICHIOMETRY r77 1691
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r77 1692
type: Stoichiometry
physical entity: Complex (PSD-95/PolyQ Htt)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r77 1690
type: Stoichiometry
physical entity: Complex (NMDA receptor/PSD-95/ Kainate receptor/Htt/ HAP1/Duo)
stoichiometric coefficient: 1.0

ADP-ribosylation factor-interacting protein 2
type: ProteinReference
xref: uniprot A0A1D5RK09 1095
xref: PTHR12141:SF3
organism: Macaca mulatta

Hippi
type: ProteinReference
xref: P00794
standard name: Hip1 protein interactor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Hip1 protein interactor Synonym: Synonym not specified Accession: P00794
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Hippi
member entity reference: Intraflagellar transport protein 57 homolog
member entity reference: Uncharacterized protein
member entity reference: IFT57 isoform 1
member entity reference: Intraflagellar transport 57

uniprot P0CN74 943
type: UnificationXref
id: P0CN74
db: uniprot

Tumor protein 63 (p63)
type: ProteinReference
xref: uniprot H2QNY5 695
xref: PTHR11447:SF8
organism: Pan troglodytes

STATE_TRANSITION_LEFT__MLK_2-RIGHT__MLK_2-_r13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 1688
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 1689
left: MLK-2
interaction type: STATE_TRANSITION
right: MLK-2

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot E2RFB5 629
organism: Canis lupus familiaris

Bax
type: DnaRegion
entity reference: Bcl-2-associated X protein
cellular location: nucleus
comment: SPECIES_TYPE=GENE

ADP-ribosylation factor 1
type: ProteinReference
xref: uniprot G2HIU2 1427
xref: PTHR11711:SF357
organism: Pan troglodytes

uniprot A4IFP7 1377
type: UnificationXref
id: A4IFP7
db: uniprot

uniprot F6ZZG9 283
type: UnificationXref
id: F6ZZG9
db: uniprot

uniprot P63258 343
type: UnificationXref
id: P63258
db: uniprot

Dynein light chain 1, cytoplasmic
type: ProteinReference
xref: uniprot Q24117 536
xref: PTHR11886:SF35
organism: Drosophila melanogaster

ADP ribosylation factor like GTPase 4D
type: ProteinReference
xref: PTHR11711:SF137
xref: uniprot F6S4U6 1414
organism: Monodelphis domestica

uniprot Q6PDL0 552
type: UnificationXref
id: Q6PDL0
db: uniprot

PTHR10407:SF14
type: RelationshipXref
id: PTHR10407:SF14
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BFR8 96
xref: PTHR12346:SF2
organism: Monodelphis domestica

uniprot Q68Y52 1283
type: UnificationXref
id: Q68Y52
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10676:SF314
xref: uniprot F6ZK75 489
organism: Monodelphis domestica

PTHR18966:SF417
type: RelationshipXref
id: PTHR18966:SF417
db: PANTHER Family
relationship type: By Homology

uniprot Q9VRX3 866
type: UnificationXref
id: Q9VRX3
db: uniprot

Tubulin beta chain (Fragment)
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot A7SHY4 727
organism: Nematostella vectensis

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6RCU6 1164
xref: PTHR24356:SF171
organism: Macaca mulatta

PTHR12688:SF0
type: RelationshipXref
id: PTHR12688:SF0
db: PANTHER Family
relationship type: By Homology

PTHR12688:SF1
type: RelationshipXref
id: PTHR12688:SF1
db: PANTHER Family
relationship type: By Homology

PTHR12688:SF2
type: RelationshipXref
id: PTHR12688:SF2
db: PANTHER Family
relationship type: By Homology

uniprot P45891 323
type: UnificationXref
id: P45891
db: uniprot

uniprot P32882 803
type: UnificationXref
id: P32882
db: uniprot

Tubulin beta-4B chain
type: ProteinReference
xref: PTHR11588:SF247
xref: uniprot Q3MHM5 825
organism: Bos taurus

PTHR18966:SF407
type: RelationshipXref
id: PTHR18966:SF407
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: PTHR48013:SF17
xref: uniprot A0A2I3SB47 1305
organism: Pan troglodytes

uniprot Q6YW27 1509
type: UnificationXref
id: Q6YW27
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot F6WX28 423
organism: Monodelphis domestica

PTHR18966:SF400
type: RelationshipXref
id: PTHR18966:SF400
db: PANTHER Family
relationship type: By Homology

uniprot F6XUU0 281
type: UnificationXref
id: F6XUU0
db: uniprot

Tumor protein p73
type: ProteinReference
xref: uniprot B0S576 673
xref: PTHR11447:SF21
organism: Danio rerio

uniprot F1P6B8 1086
type: UnificationXref
id: F1P6B8
db: uniprot

GDP
type: SmallMolecule
cellular location: synapse
comment: SPECIES_TYPE=ION

Tubulin beta chain
type: ProteinReference
xref: uniprot E2QSF4 745
xref: PTHR11588:SF61
organism: Canis lupus familiaris

Uncharacterized protein
type: DnaReference
xref: PTHR44154:SF1
organism: Gallus gallus

uniprot P54256 611
type: UnificationXref
id: P54256
db: uniprot

uniprot Q6GLE7 839
type: UnificationXref
id: Q6GLE7
db: uniprot

uniprot Q96JB1 575
type: UnificationXref
id: Q96JB1
db: uniprot

Ras-related protein rac-2
type: ProteinReference
xref: uniprot Q94124 1297
organism: Caenorhabditis elegans

Yarrowia lipolytica
type: BioSource
xref: ncbitaxon 284591 91

uniprot P34147 1249
type: UnificationXref
id: P34147
db: uniprot

uniprot A8BSP4 905
type: UnificationXref
id: A8BSP4
db: uniprot

Calpain-8
type: ProteinReference
xref: uniprot Q91VA3 167
xref: PTHR10183:SF374
organism: Mus musculus

PTHR22845:SF5
type: RelationshipXref
id: PTHR22845:SF5
db: PANTHER Family
relationship type: By Homology

Transcription factor Sp1
type: ProteinReference
xref: uniprot O89090 1123
organism: Mus musculus

uniprot O44518 697
type: UnificationXref
id: O44518
db: uniprot

uniprot Q7KQL3 1512
type: UnificationXref
id: Q7KQL3
db: uniprot

Dynein light chain
type: ProteinReference
xref: uniprot Q6PBH4 551
xref: PTHR11886:SF62
organism: Danio rerio

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot Q3ZC07 371
organism: Bos taurus

Htt
type: Protein
entity reference: Htt
feature: COMPLEX PARTICIPANT BINDING FEATURE s109 sa52 1609
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot P34149 1251
type: UnificationXref
id: P34149
db: uniprot

Dynein light chain 1, cytoplasmic
type: ProteinReference
xref: PTHR11886:SF91
xref: uniprot P61285 525
organism: Bos taurus

ncbitaxon 243090 1537
type: UnificationXref
id: 243090
db: ncbitaxon

Cytochrome c1 1, heme protein, mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q9LK29 1205
organism: Arabidopsis thaliana

TP53I3 isoform 2
type: DnaReference
xref: PTHR48106:SF8
organism: Pan troglodytes

Ras-related protein Rab-8A
type: ProteinReference
xref: uniprot P35280 1027
organism: Rattus norvegicus

Thermococcus kodakaraensis
type: BioSource
xref: ncbitaxon 69014 1350

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot Q9VF87 715
organism: Drosophila melanogaster

uniprot Q6RUV5 1288
type: UnificationXref
id: Q6RUV5
db: uniprot

uniprot Q5BJ82 1499
type: UnificationXref
id: Q5BJ82
db: uniprot

uniprot P68032 351
type: UnificationXref
id: P68032
db: uniprot

PolyQ Htt s2 a2 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Proline dehydrogenase, mitochondrial
type: DnaReference
organism: Saccharomyces cerevisiae

Cytochrome c1, heme protein, mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot P07143 1194
organism: Saccharomyces cerevisiae

uniprot P40617 1452
type: UnificationXref
id: P40617
db: uniprot

Cytochrome c1, heme protein, mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot P07142 1193
organism: Neurospora crassa

uniprot O77628 425
type: UnificationXref
id: O77628
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12346:SF1
xref: uniprot F6YZ56 93
organism: Macaca mulatta

uniprot Q8ILW9 407
type: UnificationXref
id: Q8ILW9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot F7DIB7 287
organism: Monodelphis domestica

uniprot Q3SYX9 1052
type: UnificationXref
id: Q3SYX9
db: uniprot

uniprot A0A1D5RCQ6 437
type: UnificationXref
id: A0A1D5RCQ6
db: uniprot

uniprot Q8BMF5 659
type: UnificationXref
id: Q8BMF5
db: uniprot

uniprot F6R1R1 1117
type: UnificationXref
id: F6R1R1
db: uniprot

Cytoplasmic FMR1-interacting protein 2
type: ProteinReference
xref: uniprot Q5SQX6 705
organism: Mus musculus

uniprot F1MUW4 1110
type: UnificationXref
id: F1MUW4
db: uniprot

uniprot E1BGW5 87
type: UnificationXref
id: E1BGW5
db: uniprot

uniprot O35350 143
type: UnificationXref
id: O35350
db: uniprot

PTHR15751:SF14
type: RelationshipXref
id: PTHR15751:SF14
db: PANTHER Family
relationship type: By Homology

Proline dehydrogenase 1, mitochondrial
type: DnaReference
organism: Drosophila melanogaster

uniprot A0A2I3RKD8 671
type: UnificationXref
id: A0A2I3RKD8
db: uniprot

uniprot Q9WV32 1065
type: UnificationXref
id: Q9WV32
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RI38 1375
xref: PTHR11711:SF357
organism: Macaca mulatta

uniprot A7F7Z6 1209
type: UnificationXref
id: A7F7Z6
db: uniprot

Glutamate receptor ionotropic, kainate 4
type: ProteinReference
xref: uniprot Q01812 649
xref: PTHR18966:SF171
organism: Rattus norvegicus

uniprot F1RCB6 268
type: UnificationXref
id: F1RCB6
db: uniprot

actin, muscle
type: ProteinReference
xref: uniprot F6SDC9 276
organism: Ciona intestinalis

Huntingtin
type: DnaReference
xref: PTHR10170:SF10
organism: Mus musculus

uniprot G5EDC6 1429
type: UnificationXref
id: G5EDC6
db: uniprot

uniprot O00401 1071
type: UnificationXref
id: O00401
db: uniprot

uniprot O75182 102
type: UnificationXref
id: O75182
db: uniprot

By Homology
type: RelationshipTypeVocabulary

uniprot A8JAV1 210
type: UnificationXref
id: A8JAV1
db: uniprot

Sp1, isoform F
type: ProteinReference
xref: PTHR23235:SF15
xref: uniprot M9PJG1 1122
organism: Drosophila melanogaster

uniprot A8WMU9 1383
type: UnificationXref
id: A8WMU9
db: uniprot

PIG3
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot A8BSP4 905
organism: Giardia intestinalis

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BIX3 119
xref: PTHR46143:SF1
organism: Bos taurus

uniprot A8WS37 214
type: UnificationXref
id: A8WS37
db: uniprot

uniprot O00268 180
type: UnificationXref
id: O00268
db: uniprot

uniprot Q14790 1108
type: UnificationXref
id: Q14790
db: uniprot

Htt
type: Protein
entity reference: Htt
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa14 1641
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 6239 48
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot Q29RC5 1272
type: UnificationXref
id: Q29RC5
db: uniprot

uniprot B7PJZ9 454
type: UnificationXref
id: B7PJZ9
db: uniprot

Complex (Hip-12/Hip-1/ Clathrin/alpha-Adaptin/ Htt/Actin)
type: Complex
component stoichiometry: Htt s86 sa40 STOICHIOMETRY ID COMPLEX
component stoichiometry: Hip 1 s83 sa37 STOICHIOMETRY ID COMPLEX
component stoichiometry: alpha Adaptin s85 sa39 STOICHIOMETRY ID COMPLEX
component stoichiometry: Clathrin s84 sa38 STOICHIOMETRY ID COMPLEX
component stoichiometry: Arp2 3 complex s241 a175 STOICHIOMETRY ID COMPLEX
component stoichiometry: Hip 12 s82 sa36 STOICHIOMETRY ID COMPLEX
component: Hip-12
component: Actin
component: Htt
component: Clathrin
component: Hip-1
component: alpha-Adaptin
component: Arp2/3 complex
feature: COMPLEX BINDING FEATURE s166 a223 1628
feature: COMPLEX BINDING FEATURE s166 a223 1620
feature: COMPLEX BINDING FEATURE s166 a223 1626
feature: COMPLEX BINDING FEATURE s166 a223 1624
feature: COMPLEX BINDING FEATURE s166 a223 1622
feature: COMPLEX BINDING FEATURE s166 a223 1630
feature: COMPLEX BINDING FEATURE s166 a223 1618
cellular location: clathrin coat of endocytic vesicle

PTHR22878:SF61
type: RelationshipXref
id: PTHR22878:SF61
db: PANTHER Family
relationship type: By Homology

Akt
type: ProteinReference
xref: P00805
standard name: protein kinase B
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Akt
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Thymoma Viral Proto-Oncogene 1 Synonym: PKB,PKB/Akt,Pkb alpha Accession: P00805
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC-gamma serine/threonine-protein kinase
member entity reference: RAC-beta serine/threonine-protein kinase
member entity reference: RAC-alpha serine/threonine-protein kinase

uniprot H2QVA9 1070
type: UnificationXref
id: H2QVA9
db: uniprot

uniprot F1PMM7 683
type: UnificationXref
id: F1PMM7
db: uniprot

Htt
type: Protein
entity reference: Htt
feature: COMPLEX PARTICIPANT BINDING FEATURE s73 sa29 1585
cellular location: clathrin coat of endocytic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot P37276 522
type: UnificationXref
id: P37276
db: uniprot

DYNC1I1 isoform 4
type: ProteinReference
xref: PTHR12442:SF34
xref: uniprot H2QUY9 508
organism: Pan troglodytes

uniprot Q2PEE1 539
type: UnificationXref
id: Q2PEE1
db: uniprot

STATE_TRANSITION_LEFT__Apaf_1-RIGHT__Apaf_1-_r30
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 1720
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 1719
left: Apaf-1
interaction type: STATE_TRANSITION
right: Apaf-1

uniprot P85108 814
type: UnificationXref
id: P85108
db: uniprot

Actin-related protein 2/3 complex subunit 1A
type: ProteinReference
xref: uniprot Q1JP79 1051
xref: PTHR10709:SF11
organism: Bos taurus

uniprot W4XVG8 870
type: UnificationXref
id: W4XVG8
db: uniprot

uniprot A9RDK9 910
type: UnificationXref
id: A9RDK9
db: uniprot

DISSOCIATION_LEFT__Complex__PolyQ_Htt_GAPDH_-RIGHT__GAPDH-_PolyQ_Htt-_r55
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 1738
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 1739
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 1740
left: Complex (PolyQ Htt/GAPDH)
interaction type: DISSOCIATION
right: PolyQ Htt
right: GAPDH

uniprot Q2HJ81 821
type: UnificationXref
id: Q2HJ81
db: uniprot

ADP-ribosylation factor
type: ProteinReference
xref: uniprot Q7RVM2 1516
xref: PTHR11711:SF30
organism: Neurospora crassa

Tubulin beta-1 chain
type: ProteinReference
xref: PTHR11588:SF361
xref: uniprot Q43594 829
organism: Oryza sativa

ACTIVE 84
type: EntityFeature
comment: Active state

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot Q9Y243 1175
organism: Homo sapiens

uniprot P63260 345
type: UnificationXref
id: P63260
db: uniprot

Htt
type: Protein
entity reference: Htt
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa10 1549
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
type: ProteinReference
xref: uniprot Q9ESV6 989
organism: Rattus norvegicus

Huntingtin interacting protein 1
type: ProteinReference
xref: PTHR10407:SF14
xref: uniprot H2QUS3 431
organism: Pan troglodytes

uniprot Q3MHR3 540
type: UnificationXref
id: Q3MHR3
db: uniprot

Tubulin beta-8 chain
type: ProteinReference
xref: uniprot P29516 800
xref: PTHR11588:SF389
organism: Arabidopsis thaliana

uniprot A5A6H0 420
type: UnificationXref
id: A5A6H0
db: uniprot

Tubulin beta-9 chain
type: ProteinReference
xref: uniprot P29517 801
xref: PTHR11588:SF395
organism: Arabidopsis thaliana

Evidence 27
type: Evidence
evidence code: ISS
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html

uniprot O96622 1048
type: UnificationXref
id: O96622
db: uniprot

PTHR18966:SF497
type: RelationshipXref
id: PTHR18966:SF497
db: PANTHER Family
relationship type: By Homology

uniprot W4XVG9 871
type: UnificationXref
id: W4XVG9
db: uniprot

Rac-like GTP-binding protein ARAC9
type: ProteinReference
xref: uniprot Q9XGU0 1304
organism: Arabidopsis thaliana

Dynein light chain 1, cytoplasmic
type: ProteinReference
xref: uniprot Q22799 535
xref: PTHR11886:SF35
organism: Caenorhabditis elegans

ADP-ribosylation factor-like protein 1
type: ProteinReference
xref: uniprot P61212 1466
xref: PTHR11711:SF41
organism: Rattus norvegicus

ADP-ribosylation factor-like protein 1
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot P61211 1465
organism: Mus musculus

uniprot D4A8H8 674
type: UnificationXref
id: D4A8H8
db: uniprot

Caspase 3
type: ProteinReference
xref: P00812
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Caspase 3 Synonym: Synonym not specified Accession: P00812
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Caspase 3
member entity reference: Caspase-3
member entity reference: Caspase 3, apoptosis-related cysteine peptidase a
member entity reference: Uncharacterized protein

ADP-ribosylation factor-like protein 4A
type: ProteinReference
xref: PTHR11711:SF139
xref: uniprot P61214 1468
organism: Rattus norvegicus

ADP-ribosylation factor-like protein 4A
type: ProteinReference
xref: PTHR11711:SF139
xref: uniprot P61213 1467
organism: Mus musculus

Clathrin
type: ProteinReference
xref: P00798
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Clathrin
comment: ENTITY_REFERENCE_NOTES= Long Name: Clathrin Synonym: Synonym not specified Accession: P00798
member entity reference: Clathrin light chain B
member entity reference: Clathrin light chain
member entity reference: Clathrin light chain A

uniprot P04975 663
type: UnificationXref
id: P04975
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase 2
type: ProteinReference
xref: uniprot Q5MJ86 973
organism: Danio rerio

uniprot P97571 155
type: UnificationXref
id: P97571
db: uniprot

Glutamate receptor ionotropic, NMDA 2C
type: ProteinReference
evidence: Evidence 49
evidence: Evidence 54
xref: PTHR18966:SF361
xref: uniprot Q01098 65
organism: Mus musculus

Rac s96 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 49
evidence: Evidence 58
xref: uniprot Q01097 64
xref: PTHR18966:SF382
organism: Mus musculus

Evidence 23
type: Evidence
evidence code: ISS
comment: Website http://harvester.embl.de/harvester/Q149/Q14957.htm

Evidence 22
type: Evidence
evidence code: ISS
comment: Website http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm

Evidence 25
type: Evidence
evidence code: ISS
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html

TRANSLATION
type: InteractionVocabulary

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 95

Evidence 24
type: Evidence
evidence code: ISS
comment: Website http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436

Htt
type: Protein
entity reference: Htt
feature: COMPLEX PARTICIPANT BINDING FEATURE s86 sa40 1629
cellular location: clathrin coat of endocytic vesicle
comment: SPECIES_TYPE=PROTEIN

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot P68033 352
organism: Mus musculus

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot P68032 351
organism: Homo sapiens

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: uniprot P68035 354
xref: PTHR11937:SF176
organism: Rattus norvegicus

Brain-derived neurotrophic factor (Fragment)
type: DnaReference
xref: PTHR11589:SF3
organism: Ornithorhynchus anatinus

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot P68034 353
organism: Gallus gallus

Caspase 6
type: Protein
entity reference: Caspase 6
feature: ACTIVE 84
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q8ZVR0 1359
organism: Pyrobaculum aerophilum

uniprot Q6ZM67 77
type: UnificationXref
id: Q6ZM67
db: uniprot

Rac-like GTP-binding protein 5
type: ProteinReference
xref: uniprot Q6EP31 1285
organism: Oryza sativa

uniprot Q5IS46 655
type: UnificationXref
id: Q5IS46
db: uniprot

Evidence 58
type: Evidence
evidence code: IDA
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html

Evidence 57
type: Evidence
evidence code: IDA
comment: Website http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436

Evidence 55
type: Evidence
evidence code: IDA
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html

Evidence 54
type: Evidence
evidence code: IDA
comment: Website http://harvester.embl.de/harvester/Q149/Q14957.htm

Tubulin beta-6 chain
type: ProteinReference
xref: PTHR11588:SF88
xref: uniprot Q922F4 859
organism: Mus musculus

uniprot P09497 665
type: UnificationXref
id: P09497
db: uniprot

c Jun s115 sa6 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r15 1674
type: Stoichiometry
physical entity: MAPKK7
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r15 1675
type: Stoichiometry
physical entity: MAPKK7
stoichiometric coefficient: 1.0

MAP2K4 protein
type: ProteinReference
xref: uniprot A5PJP8 1321
xref: PTHR48013:SF15
organism: Bos taurus

Evidence 49
type: Evidence
evidence code: IDA
comment: Website http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm

uniprot P15153 1243
type: UnificationXref
id: P15153
db: uniprot

Dynactin subunit 1 isoform 1
type: ProteinReference
xref: uniprot F6T5J5 1311
xref: PTHR18916:SF6
organism: Macaca mulatta

Tubulin beta chain
type: ProteinReference
xref: uniprot F7CB79 765
xref: PTHR11588:SF88
organism: Monodelphis domestica

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P60952 1256
organism: Canis lupus familiaris

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot F6WN02 1036
xref: PTHR12644:SF1
organism: Ornithorhynchus anatinus

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P60953 1257
organism: Homo sapiens

uniprot A0A1D5PRH4 1531
type: UnificationXref
id: A0A1D5PRH4
db: uniprot

Ras-related protein ced-10
type: ProteinReference
xref: uniprot Q03206 1265
organism: Caenorhabditis elegans

uniprot A0A2I3S1J9 620
type: UnificationXref
id: A0A2I3S1J9
db: uniprot

uniprot Q09472 1012
type: UnificationXref
id: Q09472
db: uniprot

Tubulin beta-4A chain
type: ProteinReference
xref: uniprot P04350 786
xref: PTHR11588:SF253
organism: Homo sapiens

uniprot F6TDQ6 636
type: UnificationXref
id: F6TDQ6
db: uniprot

uniprot Q45VK7 541
type: UnificationXref
id: Q45VK7
db: uniprot

uniprot P45444 524
type: UnificationXref
id: P45444
db: uniprot

uniprot H2QC53 694
type: UnificationXref
id: H2QC53
db: uniprot

ADP-ribosylation factor 1
type: ProteinReference
xref: uniprot P61209 1464
xref: PTHR11711:SF381
organism: Drosophila melanogaster

ADP-ribosylation factor-like protein 4C
type: ProteinReference
xref: uniprot P61208 1463
xref: PTHR11711:SF119
organism: Mus musculus

Glutamate ionotropic receptor kainate type subunit 1
type: ProteinReference
xref: uniprot F6S5B1 635
xref: PTHR18966:SF36
organism: Monodelphis domestica

NADPH quinone oxidoreductase, putative
type: DnaReference
organism: Deinococcus radiodurans

uniprot A7S214 1379
type: UnificationXref
id: A7S214
db: uniprot

uniprot F1LML7 1085
type: UnificationXref
id: F1LML7
db: uniprot

ADP-ribosylation factor 3
type: ProteinReference
xref: PTHR11711:SF316
xref: uniprot P61206 1462
organism: Rattus norvegicus

ADP-ribosylation factor 3
type: ProteinReference
xref: PTHR11711:SF316
xref: uniprot P61205 1461
organism: Mus musculus

ADP-ribosylation factor 3
type: ProteinReference
xref: PTHR11711:SF316
xref: uniprot P61204 1460
organism: Homo sapiens

Hip-1
type: Protein
entity reference: Hip-1
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot P34145 1247
type: UnificationXref
id: P34145
db: uniprot

ADP-ribosylation factor 2
type: ProteinReference
xref: uniprot P51823 1458
xref: PTHR11711:SF30
organism: Oryza sativa

uniprot F6Z879 1324
type: UnificationXref
id: F6Z879
db: uniprot

uniprot Q5BL99 543
type: UnificationXref
id: Q5BL99
db: uniprot

uniprot Q16478 653
type: UnificationXref
id: Q16478
db: uniprot

uniprot F6Q1J4 920
type: UnificationXref
id: F6Q1J4
db: uniprot

uniprot P40793 1253
type: UnificationXref
id: P40793
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot H2QV01 1042
xref: PTHR10709:SF10
organism: Pan troglodytes

uniprot H2RBT6 135
type: UnificationXref
id: H2RBT6
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot H2QV00 1041
xref: PTHR10709:SF11
organism: Pan troglodytes

ncbitaxon 9606 18
type: UnificationXref
id: 9606
db: ncbitaxon

Huntingtin-associated protein 1
type: ProteinReference
xref: PTHR15751:SF14
xref: uniprot P54256 611
organism: Rattus norvegicus

Huntingtin-associated protein 1
type: ProteinReference
xref: PTHR15751:SF14
xref: uniprot P54257 612
organism: Homo sapiens

uniprot Q24117 536
type: UnificationXref
id: Q24117
db: uniprot

GRIK3 isoform 1
type: ProteinReference
xref: PTHR18966:SF174
xref: uniprot C7G3L6 627
organism: Pan troglodytes

GRIK2 isoform 3
type: ProteinReference
xref: uniprot C7G3L5 626
xref: PTHR18966:SF38
organism: Pan troglodytes

Tubulin beta chain (Fragment)
type: ProteinReference
xref: uniprot B7Q717 739
xref: PTHR11588:SF293
organism: Ixodes scapularis

uniprot B0S576 673
type: UnificationXref
id: B0S576
db: uniprot

Intraflagellar transport protein 57 homolog
type: ProteinReference
xref: uniprot Q9NWB7 1094
xref: PTHR16011:SF0
organism: Homo sapiens

uniprot F7A4B3 1231
type: UnificationXref
id: F7A4B3
db: uniprot

Proline dehydrogenase
type: DnaReference
organism: Emericella nidulans

Arf1_5/ArfA-family small GTPase
type: ProteinReference
xref: PTHR11711:SF390
xref: uniprot A9TBY6 1387
organism: Physcomitrella patens

uniprot E2RFB5 629
type: UnificationXref
id: E2RFB5
db: uniprot

Caspase-3
type: ProteinReference
xref: uniprot Q8MKI5 1152
xref: PTHR10454:SF198
organism: Canis lupus familiaris

Predicted protein
type: ProteinReference
xref: uniprot A9TBY8 1388
xref: PTHR11711:SF390
organism: Physcomitrella patens

uniprot Q3KRE8 824
type: UnificationXref
id: Q3KRE8
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot F6WN64 1037
xref: PTHR12644:SF2
organism: Monodelphis domestica

ncbitaxon 188937 1356
type: UnificationXref
id: 188937
db: ncbitaxon

uniprot F6XQ37 762
type: UnificationXref
id: F6XQ37
db: uniprot

Tubulin beta-6 chain
type: ProteinReference
xref: uniprot Q76FS3 852
xref: PTHR11588:SF321
organism: Oryza sativa

TRANSLATION_LEFT__PolyQ_HTT-RIGHT__PolyQ_Htt-_re78
type: TemplateReaction
product: PolyQ Htt
xref: TRANSLATION
participant: PolyQ Htt
participant: PolyQ HTT
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

Tubulin beta-8 chain
type: ProteinReference
xref: PTHR11588:SF334
xref: uniprot Q76FS2 851
organism: Oryza sativa

uniprot Q12731 1343
type: UnificationXref
id: Q12731
db: uniprot

ncbitaxon 10090 15
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot B2RWS6 1001
type: UnificationXref
id: B2RWS6
db: uniprot

Calpain 6
type: ProteinReference
xref: uniprot E1BJ18 120
xref: PTHR10183:SF381
organism: Bos taurus

uniprot E9H8L6 467
type: UnificationXref
id: E9H8L6
db: uniprot

JNK-2
type: Protein
entity reference: JNK-2
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot C4M5Q7 1217
type: UnificationXref
id: C4M5Q7
db: uniprot

Dynein light chain 2, cytoplasmic
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot Q3MHR3 540
organism: Bos taurus

alpha Adaptin s85 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha-Adaptin
stoichiometric coefficient: 1.0

uniprot E2QUL1 31
type: UnificationXref
id: E2QUL1
db: uniprot

uniprot Q56YW9 836
type: UnificationXref
id: Q56YW9
db: uniprot

Cytoplasmic dynein 1 intermediate chain 2
type: ProteinReference
xref: uniprot Q62871 547
xref: PTHR12442:SF37
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION_LEFT__Complex__Hip_12_Hip_1_-_alpha_Adaptin-_Clathrin-_Actin-_Htt-RIGHT__Complex__Hip_12_Hip_1__Clathrin_alpha_Adaptin__Htt_Actin_-_r81
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 1660
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 1656
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 1659
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 1658
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 1657
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 1661
left: Clathrin
left: alpha-Adaptin
left: Complex (Hip-12/Hip-1)
left: Htt
left: Actin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Hip-12/Hip-1/ Clathrin/alpha-Adaptin/ Htt/Actin)

ncbitaxon 5722 194
type: UnificationXref
id: 5722
db: ncbitaxon

uniprot Q562R1 375
type: UnificationXref
id: Q562R1
db: uniprot

eco ECO:0000353 433
type: UnificationXref
id: ECO:0000353
db: eco

P00810
type: UnificationXref
id: P00810
db: PANTHER Pathway Component

P00813
type: UnificationXref
id: P00813
db: PANTHER Pathway Component

P00811
type: UnificationXref
id: P00811
db: PANTHER Pathway Component

P00812
type: UnificationXref
id: P00812
db: PANTHER Pathway Component

ncbitaxon 665079 200
type: UnificationXref
id: 665079
db: ncbitaxon

uniprot F0ZK40 264
type: UnificationXref
id: F0ZK40
db: uniprot

uniprot O59680 1191
type: UnificationXref
id: O59680
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12442:SF37
xref: uniprot F1P3C8 474
organism: Gallus gallus

Evidence 81
type: Evidence
evidence code: IDA
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html

Zeta-crystallin
type: DnaReference
xref: PTHR44154:SF1
organism: Bos taurus

Dynactin s69 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Dynactin
stoichiometric coefficient: 1.0

uniprot P60766 1255
type: UnificationXref
id: P60766
db: uniprot

P00804
type: UnificationXref
id: P00804
db: PANTHER Pathway Component

P00805
type: UnificationXref
id: P00805
db: PANTHER Pathway Component

P00806
type: UnificationXref
id: P00806
db: PANTHER Pathway Component

P00807
type: UnificationXref
id: P00807
db: PANTHER Pathway Component

uniprot P91926 891
type: UnificationXref
id: P91926
db: uniprot

P00808
type: UnificationXref
id: P00808
db: PANTHER Pathway Component

P00809
type: UnificationXref
id: P00809
db: PANTHER Pathway Component

Optineurin
type: ProteinReference
xref: uniprot Q861Q8 1141
organism: Macaca mulatta

P00800
type: UnificationXref
id: P00800
db: PANTHER Pathway Component

P00801
type: UnificationXref
id: P00801
db: PANTHER Pathway Component

P00802
type: UnificationXref
id: P00802
db: PANTHER Pathway Component

P00803
type: UnificationXref
id: P00803
db: PANTHER Pathway Component

uniprot P31749 1168
type: UnificationXref
id: P31749
db: uniprot

uniprot A2EM81 723
type: UnificationXref
id: A2EM81
db: uniprot

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 1348

uniprot F1MQD1 123
type: UnificationXref
id: F1MQD1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR13992:SF5
xref: uniprot F1MGM4 1367
organism: Bos taurus

AP-2 complex subunit alpha
type: ProteinReference
xref: PTHR22780:SF4
xref: uniprot P91926 891
organism: Drosophila melanogaster

uniprot Q8RYC2 408
type: UnificationXref
id: Q8RYC2
db: uniprot

Actin
type: Protein
entity reference: Actin

Vesicle amine transport 1 like
type: DnaReference
xref: PTHR44054:SF2
organism: Gallus gallus

HAP1 s113 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: HAP1
stoichiometric coefficient: 1.0

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 79

uniprot P55258 1028
type: UnificationXref
id: P55258
db: uniprot

uniprot Q9H3D4 712
type: UnificationXref
id: Q9H3D4
db: uniprot

Arfaptin-2
type: ProteinReference
xref: PTHR12141:SF3
xref: uniprot Q8K221 1102
organism: Mus musculus

uniprot Q9FYH1 1017
type: UnificationXref
id: Q9FYH1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RNQ7 1400
xref: PTHR11711:SF357
organism: Canis lupus familiaris

uniprot F1QLH0 1104
type: UnificationXref
id: F1QLH0
db: uniprot

Huntingtin-associated protein 1
type: ProteinReference
xref: uniprot O35668 610
xref: PTHR15751:SF14
organism: Mus musculus

uniprot A4FV20 1208
type: UnificationXref
id: A4FV20
db: uniprot

ADP ribosylation factor-like 4, isoform B
type: ProteinReference
xref: uniprot H9XVM3 1439
organism: Drosophila melanogaster

ADP ribosylation factor like GTPase 4A
type: ProteinReference
xref: PTHR11711:SF139
xref: uniprot E2RNQ0 1399
organism: Canis lupus familiaris

Glutamate receptor ionotropic, kainate 1
type: ProteinReference
xref: PTHR18966:SF36
xref: uniprot P39086 645
organism: Homo sapiens

Putative quinone oxidoreductase
type: DnaReference
xref: PTHR48106:SF8
organism: Streptomyces coelicolor

Glutamate receptor ionotropic, kainate 2
type: ProteinReference
xref: uniprot P39087 646
xref: PTHR18966:SF38
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GDJ8 1121
organism: Macaca mulatta

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot F1PMM7 683
organism: Canis lupus familiaris

uniprot A0A2I3T979 621
type: UnificationXref
id: A0A2I3T979
db: uniprot

uniprot P00360 932
type: UnificationXref
id: P00360
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot S4R1W1 1000
xref: PTHR10836:SF111
organism: Mus musculus

GO GO:0045202 5
type: UnificationXref
id: GO:0045202
db: GO

Uncharacterized protein
type: ProteinReference
xref: uniprot A7F7Z6 1209
organism: Sclerotinia sclerotiorum

uniprot Q8ZVR0 1359
type: UnificationXref
id: Q8ZVR0
db: uniprot

uniprot P84081 1478
type: UnificationXref
id: P84081
db: uniprot

uniprot F7A5M9 687
type: UnificationXref
id: F7A5M9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF477
xref: uniprot F7A7I3 284
organism: Monodelphis domestica

uniprot Q0J8A4 964
type: UnificationXref
id: Q0J8A4
db: uniprot

ncbitaxon 6945 233
type: UnificationXref
id: 6945
db: ncbitaxon

AP-2 complex subunit alpha
type: ProteinReference
xref: PTHR22780:SF33
xref: uniprot A0A1D5Q8J6 877
organism: Macaca mulatta

PTHR14167:SF45
type: RelationshipXref
id: PTHR14167:SF45
db: PANTHER Family
relationship type: By Homology

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot E2RFR5 463
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Arp2_3_complex-RIGHT__Arp2_3_complex-_r66
controller: Complex (Htt/SH3GL3/ PACSIN-1/Synaptojanin/ N-Wasp)

uniprot E3K4I1 255
type: UnificationXref
id: E3K4I1
db: uniprot

TATA-box binding protein
type: ProteinReference
xref: PTHR10126:SF20
xref: uniprot H2RD22 1331
organism: Pan troglodytes

ADP-ribosylation factor, variant
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot E3JPY7 1401
organism: Puccinia graminis

uniprot Q4QBZ6 832
type: UnificationXref
id: Q4QBZ6
db: uniprot

ncbitaxon 284812 317
type: UnificationXref
id: 284812
db: ncbitaxon

Calpain-6
type: ProteinReference
xref: PTHR10183:SF381
xref: uniprot O35646 144
organism: Mus musculus

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot Q90694 1296
organism: Gallus gallus

uniprot E9PTN6 918
type: UnificationXref
id: E9PTN6
db: uniprot

Arp2/3 complex
type: ProteinReference
xref: P00811
standard name: Actin related protein 2/3 complex
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Arp2/3 complex
comment: ENTITY_REFERENCE_NOTES= Long Name: Actin-related protein 2 and 3 complex Synonym: Synonym not specified Accession: P00811
member entity reference: Actin-related protein 2/3 complex subunit
member entity reference: Actin-related protein 2/3 complex subunit 5-like protein
member entity reference: Actin-related protein 2/3 complex subunit 1B
member entity reference: Actin-related protein 2/3 complex subunit 5
member entity reference: Actin-related protein 2/3 complex subunit 1
member entity reference: Actin-related protein 2/3 complex subunit 1A

uniprot P56424 701
type: UnificationXref
id: P56424
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot P04406 933
xref: PTHR10836:SF111
organism: Homo sapiens

uniprot A0A452DIR3 1083
type: UnificationXref
id: A0A452DIR3
db: uniprot

uniprot C3Z4K3 248
type: UnificationXref
id: C3Z4K3
db: uniprot

uniprot F1N5R7 471
type: UnificationXref
id: F1N5R7
db: uniprot

ADP-ribosylation factor
type: ProteinReference
xref: PTHR11711:SF385
xref: uniprot Q7XZG0 1517
organism: Oryza sativa

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1M3Y3 1310
xref: PTHR18916:SF6
organism: Bos taurus

SIN3 transcription regulator family member A
type: ProteinReference
xref: uniprot A0A0G2K3H5 86
xref: PTHR12346:SF2
organism: Rattus norvegicus

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot A8WNX0 908
organism: Caenorhabditis briggsae

ADP-ribosylation factor-like protein 1
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot Q4QEJ1 1494
organism: Leishmania major

uniprot H2QUS3 431
type: UnificationXref
id: H2QUS3
db: uniprot

Htt
type: Protein
entity reference: Htt
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

CAPN10 isoform 1
type: ProteinReference
xref: PTHR10183:SF30
xref: uniprot K7CKA1 138
organism: Pan troglodytes

ncbitaxon 44689 306
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot H2QJ86 1106
type: UnificationXref
id: H2QJ86
db: uniprot

DISSOCIATION
type: InteractionVocabulary

uniprot H2QS62 605
type: UnificationXref
id: H2QS62
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10676:SF344
xref: uniprot F7GQS3 497
organism: Macaca mulatta

Tumor necrosis factor alpha-induced protein 8
type: ProteinReference
xref: uniprot O95379 1139
organism: Homo sapiens

Hip 1 s83 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Hip-1
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__PUMA-RIGHT__PUMA-_re69
type: TemplateReaction
product: PUMA
xref: TRANSCRIPTION
participant: PUMA
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot Q9JJP6 714
type: UnificationXref
id: Q9JJP6
db: uniprot

uniprot P0CY33 1242
type: UnificationXref
id: P0CY33
db: uniprot

Dynein heavy chain at 93AB, isoform C
type: ProteinReference
xref: uniprot A0A0B4KHJ4 434
xref: PTHR10676:SF374
organism: Drosophila melanogaster

Cytoplasmic dynein heavy chain 2
type: ProteinReference
xref: uniprot A0A0D1DSG8 435
xref: PTHR10676:SF314
organism: Ustilago maydis

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot F6XSJ9 1229
organism: Macaca mulatta

Kainate receptor
type: ProteinReference
xref: P00796
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.ION_CHANNEL.Kainate_br_receptor
comment: ENTITY_REFERENCE_NOTES= Long Name: Kainate receptor Synonym: Synonym not specified Accession: P00796
member entity reference: Glutamate ionotropic receptor kainate type subunit 2
member entity reference: Glutamate ionotropic receptor kainate type subunit 3
member entity reference: Glutamate receptor ionotropic, kainate 4
member entity reference: Glutamate receptor ionotropic, kainate 2
member entity reference: Uncharacterized protein
member entity reference: Glutamate receptor ionotropic, kainate 3
member entity reference: Glutamate receptor ionotropic, kainate 5
member entity reference: GRIK3 isoform 1
member entity reference: Glutamate receptor ionotropic, kainate 1
member entity reference: Glutamate ionotropic receptor kainate type subunit 1
member entity reference: Si:dkey-183j2.10
member entity reference: GRIK2 isoform 3
member entity reference: GRIK1 protein
member entity reference: Glutamate receptor, ionotropic, kainate 5
member entity reference: Glutamate receptor, ionotropic, kainate 1b
member entity reference: Glutamate receptor, ionotropic, kainate 1
member entity reference: Probable glutamate receptor
member entity reference: GRIK1 isoform 7
member entity reference: Glutamate ionotropic receptor kainate type subunit 5

ncbitaxon 243230 996
type: UnificationXref
id: 243230
db: ncbitaxon

uniprot Q5ZI78 1140
type: UnificationXref
id: Q5ZI78
db: uniprot

uniprot F6WN02 1036
type: UnificationXref
id: F6WN02
db: uniprot

Actin-1
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P0DM41 310
organism: Caenorhabditis elegans

ncbitaxon 684364 757
type: UnificationXref
id: 684364
db: ncbitaxon

uniprot F1P6V8 475
type: UnificationXref
id: F1P6V8
db: uniprot

PARTICIPANT STOICHIOMETRY r16 1669
type: Stoichiometry
physical entity: SEK-1
stoichiometric coefficient: 1.0

SH3GL3 s74 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SH3GL3
stoichiometric coefficient: 1.0

uniprot P25856 952
type: UnificationXref
id: P25856
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: Oxidative stress
controller: PolyQ Htt

Kalirin
type: ProteinReference
xref: uniprot O60229 1534
xref: PTHR22826:SF49
organism: Homo sapiens

uniprot Q7PTQ4 555
type: UnificationXref
id: Q7PTQ4
db: uniprot

Glutamate [NMDA] receptor subunit zeta-1 isoform NR1-3
type: ProteinReference
evidence: Evidence 22
xref: uniprot F7GR67 45
xref: PTHR18966:SF377
organism: Macaca mulatta

uniprot O95782 886
type: UnificationXref
id: O95782
db: uniprot

TATA-box-binding protein B
type: ProteinReference
xref: uniprot Q48325 1347
xref: PTHR10126:SF42
organism: Halobacterium salinarum

uniprot Q80ZS7 564
type: UnificationXref
id: Q80ZS7
db: uniprot

uniprot O15484 142
type: UnificationXref
id: O15484
db: uniprot

uniprot F7E3R0 494
type: UnificationXref
id: F7E3R0
db: uniprot

PTHR10709:SF10
type: RelationshipXref
id: PTHR10709:SF10
db: PANTHER Family
relationship type: By Homology

PTHR10709:SF11
type: RelationshipXref
id: PTHR10709:SF11
db: PANTHER Family
relationship type: By Homology

uniprot C3XZ13 244
type: UnificationXref
id: C3XZ13
db: uniprot

Huntingtin
type: ProteinReference
xref: PTHR10170:SF10
xref: uniprot P42858 1022
organism: Homo sapiens

Huntingtin
type: ProteinReference
xref: PTHR10170:SF10
xref: uniprot P42859 1023
organism: Mus musculus

uniprot Q8IKK7 983
type: UnificationXref
id: Q8IKK7
db: uniprot

Hip-1
type: ProteinReference
xref: P00765
standard name: Huntington interacting protein-1
comment: ENTITY_REFERENCE_NOTES= Long Name: Huntington interacting protein-1 Synonym: Synonym not specified Accession: P00765
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Hip-1
member entity reference: Huntingtin-interacting protein 1
member entity reference: Huntingtin interacting protein 1
member entity reference: Uncharacterized protein

TAF (TBP-associated transcription factor) family
type: ProteinReference
xref: PTHR15138:SF14
xref: uniprot O61707 181
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
xref: uniprot W4Y969 416
xref: PTHR11937:SF453
organism: Strongylocentrotus purpuratus

Dynein light chain
type: ProteinReference
xref: uniprot F7AWC8 491
xref: PTHR11886:SF73
organism: Monodelphis domestica

uniprot F6ZFI9 1230
type: UnificationXref
id: F6ZFI9
db: uniprot

ADP-ribosylation factor-like protein 1
type: ProteinReference
xref: uniprot P25160 1448
xref: PTHR11711:SF41
organism: Drosophila melanogaster

uniprot Q60974 1371
type: UnificationXref
id: Q60974
db: uniprot

Calpain-2 catalytic subunit
type: ProteinReference
xref: uniprot Q07009 156
xref: PTHR10183:SF268
organism: Rattus norvegicus

uniprot F1QKY8 754
type: UnificationXref
id: F1QKY8
db: uniprot

TRANSCRIPTION
type: RelationshipTypeVocabulary

ACTin
type: ProteinReference
xref: uniprot O45815 302
xref: PTHR11937:SF359
organism: Caenorhabditis elegans

Nuclear receptor corepressor 1
type: ProteinReference
xref: PTHR13992:SF5
xref: uniprot O75376 1369
organism: Homo sapiens

uniprot Q63273 658
type: UnificationXref
id: Q63273
db: uniprot

uniprot F7H3V1 97
type: UnificationXref
id: F7H3V1
db: uniprot

uniprot P10981 312
type: UnificationXref
id: P10981
db: uniprot

uniprot E2RJX4 1156
type: UnificationXref
id: E2RJX4
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Membrane depolarization
controller: PolyQ Htt

Novel actin protein
type: ProteinReference
xref: uniprot Q6IQL9 389
xref: PTHR11937:SF176
organism: Danio rerio

uniprot P84095 1261
type: UnificationXref
id: P84095
db: uniprot

Putative quinone oxidoreductase
type: DnaReference
xref: PTHR48106:SF13
organism: Leishmania major

PARTICIPANT STOICHIOMETRY r16 1670
type: Stoichiometry
physical entity: SEK-1
stoichiometric coefficient: 1.0

Tubulin beta-4A chain
type: ProteinReference
xref: uniprot Q3ZBU7 826
xref: PTHR11588:SF253
organism: Bos taurus

uniprot Q8LPK4 896
type: UnificationXref
id: Q8LPK4
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot E9PTN6 918
xref: PTHR10836:SF111
organism: Rattus norvegicus

uniprot P60010 332
type: UnificationXref
id: P60010
db: uniprot

Protein CBR-ARL-1
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot A8WNL4 1384
organism: Caenorhabditis briggsae

uniprot Q05586 67
type: UnificationXref
id: Q05586
db: uniprot

uniprot Q6IQJ2 840
type: UnificationXref
id: Q6IQJ2
db: uniprot

uniprot G3X7B5 1167
type: UnificationXref
id: G3X7B5
db: uniprot

PARTICIPANT STOICHIOMETRY r20 1747
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 1746
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 1.0

uniprot P32256 802
type: UnificationXref
id: P32256
db: uniprot

uniprot Q9VJC6 586
type: UnificationXref
id: Q9VJC6
db: uniprot

uniprot P51111 1024
type: UnificationXref
id: P51111
db: uniprot

Bcl-2-associated X protein
type: DnaRegionReference
member entity reference: BCL2-associated X protein
member entity reference: BCL2-associated X, apoptosis regulator a
member entity reference: Uncharacterized protein
member entity reference: Apoptosis regulator BAX
xref: G01533
comment: ENTITY_REFERENCE_NOTES= Long Name: Bcl-2-associated X protein Synonym: Synonym not specified Accession: G01533
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.GENE.GENE.Bax
display name: Bax

ncbitaxon 81824 225
type: UnificationXref
id: 81824
db: ncbitaxon

Transcription initiation factor TFIID subunit 4
type: ProteinReference
xref: uniprot Q6SJR1 183
xref: PTHR15138:SF14
organism: Arabidopsis thaliana

Htt
type: Protein
entity reference: Htt
feature: COMPLEX PARTICIPANT BINDING FEATURE s91 sa44 1637
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 237631 186
type: UnificationXref
id: 237631
db: ncbitaxon

Actin
type: Protein
entity reference: Actin

uniprot O15350 696
type: UnificationXref
id: O15350
db: uniprot

uniprot H3FHL1 782
type: UnificationXref
id: H3FHL1
db: uniprot

ADP-ribosylation factor-like protein 4A
type: ProteinReference
xref: PTHR11711:SF139
xref: uniprot Q3T0M9 1493
organism: Bos taurus

Tubulin beta-6 chain
type: ProteinReference
xref: PTHR11588:SF112
xref: uniprot P09207 791
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot A0A1L1RMP9 1376
organism: Gallus gallus

Cytochrome c
type: Protein
entity reference: Cytochrome c
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__beta_Tubulin-RIGHT__beta_Tubulin-_r71
controller: Complex (Rab8/FIP-2/ Htt)

uniprot Q3T0M9 1493
type: UnificationXref
id: Q3T0M9
db: uniprot

Quinone oxidoreductase PIG3
type: DnaReference
xref: PTHR48106:SF8
organism: Homo sapiens

uniprot F6SYL0 759
type: UnificationXref
id: F6SYL0
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot H3DZP3 779
xref: PTHR11588:SF357
organism: Pristionchus pacificus

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF357
xref: uniprot H3DZP2 778
organism: Pristionchus pacificus

uniprot F7DIB7 287
type: UnificationXref
id: F7DIB7
db: uniprot

uniprot Q52WY2 1279
type: UnificationXref
id: Q52WY2
db: uniprot

uniprot Q96FJ2 574
type: UnificationXref
id: Q96FJ2
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot Q6IQJ2 840
xref: PTHR11588:SF247
organism: Danio rerio

beta-Tubulin
type: Protein
entity reference: beta-Tubulin

Tubulin beta chain
type: ProteinReference
xref: uniprot G5EF01 774
xref: PTHR11588:SF9
organism: Caenorhabditis elegans

Complex (PSD-95/PolyQ Htt)
type: Complex
component stoichiometry: PolyQ Htt s11 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: PSD 95 s10 sa3 STOICHIOMETRY ID COMPLEX
component: PSD-95
component: PolyQ Htt
feature: COMPLEX BINDING FEATURE s14 a22 1574
feature: COMPLEX BINDING FEATURE s14 a22 1572
cellular location: synapse

ADP-ribosylation factor-like protein 4C
type: ProteinReference
xref: uniprot P56559 1459
xref: PTHR11711:SF119
organism: Homo sapiens

Calpain-7
type: ProteinReference
xref: uniprot Q9R1S8 175
xref: PTHR46143:SF1
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SEK_1-RIGHT__SEK_1-_r16
controller: MLK-2

uniprot A0A1D5PEI5 717
type: UnificationXref
id: A0A1D5PEI5
db: uniprot

Cytoplasmic dynein 1 heavy chain 1
type: ProteinReference
xref: PTHR10676:SF314
xref: uniprot Q9JHU4 580
organism: Mus musculus

uniprot A9V489 224
type: UnificationXref
id: A9V489
db: uniprot

Kalirin
type: ProteinReference
xref: uniprot P97924 1535
xref: PTHR22826:SF49
organism: Rattus norvegicus

uniprot F2Z4N7 270
type: UnificationXref
id: F2Z4N7
db: uniprot

Tumor protein p53 inducible protein 3
type: DnaReference
xref: PTHR48106:SF8
organism: Canis lupus familiaris

Clathrin
type: Protein
entity reference: Clathrin
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot P49433 957
type: UnificationXref
id: P49433
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F1MYJ4 1158
organism: Bos taurus

uniprot F7AP66 490
type: UnificationXref
id: F7AP66
db: uniprot

GO GO:0005739 3
type: UnificationXref
id: GO:0005739
db: GO

C-fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot A5A6H0 420
organism: Pan troglodytes

uniprot F2Z640 90
type: UnificationXref
id: F2Z640
db: uniprot

uniprot F1Q4F8 1160
type: UnificationXref
id: F1Q4F8
db: uniprot

C-fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot A5A6H2 421
organism: Macaca mulatta

AP-2 complex subunit alpha-1
type: ProteinReference
xref: uniprot P17426 887
xref: PTHR22780:SF33
organism: Mus musculus

ncbitaxon 324602 912
type: UnificationXref
id: 324602
db: ncbitaxon

uniprot Q28BZ0 1271
type: UnificationXref
id: Q28BZ0
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF253
xref: uniprot E2RFV2 747
organism: Canis lupus familiaris

uniprot Q67G20 386
type: UnificationXref
id: Q67G20
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF88
xref: uniprot L7N3Q3 783
organism: Xenopus tropicalis

AP-2 complex subunit alpha-2
type: ProteinReference
xref: uniprot P17427 888
xref: PTHR22780:SF30
organism: Mus musculus

WASL isoform 1
type: ProteinReference
xref: PTHR23202:SF39
xref: uniprot H2QVA9 1070
organism: Pan troglodytes

Leishmania major
type: BioSource
xref: ncbitaxon 5664 413

Dynein light chain 2, cytoplasmic
type: ProteinReference
xref: uniprot Q78P75 553
xref: PTHR11886:SF35
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F1Q4F8 1160
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot F6TUR3 277
organism: Monodelphis domestica

ADP-ribosylation factor 5
type: ProteinReference
xref: uniprot H2QVB1 1435
xref: PTHR11711:SF323
organism: Pan troglodytes

Tumor necrosis factor alpha-induced protein 8
type: ProteinReference
xref: uniprot Q921Z5 1144
organism: Mus musculus

uniprot P25429 598
type: UnificationXref
id: P25429
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10676:SF310
xref: uniprot F6WDB9 484
organism: Macaca mulatta

Calpain-10
type: ProteinReference
xref: PTHR10183:SF30
xref: uniprot Q9ESK3 173
organism: Mus musculus

Caspase 8
type: ProteinReference
xref: P00808
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES= Long Name: Caspase 8 Synonym: Synonym not specified Accession: P00808
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.TRUNCATED.Caspase 8
member entity reference: Caspase 8, apoptosis-related cysteine peptidase
member entity reference: CASP8 isoform 11
member entity reference: Uncharacterized protein
member entity reference: Caspase-8

uniprot O43133 1333
type: UnificationXref
id: O43133
db: uniprot

uniprot P68138 358
type: UnificationXref
id: P68138
db: uniprot

Tubulin beta-7 chain
type: ProteinReference
xref: uniprot P09244 792
xref: PTHR11588:SF61
organism: Gallus gallus

uniprot P52653 1342
type: UnificationXref
id: P52653
db: uniprot

uniprot A0A452DJ01 115
type: UnificationXref
id: A0A452DJ01
db: uniprot

ADP ribosylation factor like GTPase 1
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot E2RG67 1397
organism: Canis lupus familiaris

Muscle-specific actin
type: ProteinReference
xref: PTHR11937:SF162
xref: uniprot E9FRT1 257
organism: Daphnia pulex

Kalirin RhoGEF kinase
type: ProteinReference
xref: uniprot F6VPX9 1533
xref: PTHR22826:SF49
organism: Monodelphis domestica

Glutamate ionotropic receptor kainate type subunit 3
type: ProteinReference
xref: PTHR18966:SF174
xref: uniprot F7ANC6 639
organism: Ornithorhynchus anatinus

Dynein cytoplasmic 1 intermediate chain 2
type: ProteinReference
xref: uniprot A0A2I3RRL1 438
xref: PTHR12442:SF37
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot F7DQK7 288
organism: Monodelphis domestica

uniprot F7H0G5 498
type: UnificationXref
id: F7H0G5
db: uniprot

uniprot P0CM16 1443
type: UnificationXref
id: P0CM16
db: uniprot

Actin 7
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9TBG2 218
organism: Physcomitrella patens

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: PTHR48013:SF17
xref: uniprot Q8CE90 1309
organism: Mus musculus

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot Q5ZJI7 1056
xref: PTHR10709:SF11
organism: Gallus gallus

Caspase-8
type: ProteinReference
xref: uniprot Q9JHX4 1109
xref: PTHR10454:SF162
organism: Rattus norvegicus

uniprot A0A3Q1M9Y0 622
type: UnificationXref
id: A0A3Q1M9Y0
db: uniprot

Calpain-12
type: ProteinReference
xref: PTHR10183:SF280
xref: uniprot Q6ZSI9 163
organism: Homo sapiens

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q5KP06 379
organism: Cryptococcus neoformans

uniprot Q9Y6Q1 177
type: UnificationXref
id: Q9Y6Q1
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot W4YJP3 874
xref: PTHR11588:SF9
organism: Strongylocentrotus purpuratus

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q9SNK3 998
organism: Oryza sativa

Brain-derived neurotrophic factor
type: DnaReference
xref: PTHR11589:SF3
organism: Mus musculus

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot Q5E9B5 378
organism: Bos taurus

Glyceraldehyde-3-phosphate dehydrogenase A
type: ProteinReference
xref: uniprot P0A9B2 939
organism: Escherichia coli

Dynein light chain
type: ProteinReference
xref: uniprot F7EXB7 495
xref: PTHR11886:SF91
organism: Ornithorhynchus anatinus

Proline dehydrogenase
type: DnaReference
organism: Rattus norvegicus

Tubulin beta-5 chain
type: ProteinReference
xref: PTHR11588:SF88
xref: uniprot P09653 794
organism: Gallus gallus

uniprot Q9BVA1 861
type: UnificationXref
id: Q9BVA1
db: uniprot

N CoR s30 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: N-CoR
stoichiometric coefficient: 1.0

Tubulin beta-4 chain
type: ProteinReference
xref: uniprot P09652 793
xref: PTHR11588:SF43
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot C3YJC1 1215
organism: Branchiostoma floridae

uniprot A0A1D5QUW3 670
type: UnificationXref
id: A0A1D5QUW3
db: uniprot

Tumor protein 63
type: ProteinReference
xref: uniprot Q9H3D4 712
xref: PTHR11447:SF8
organism: Homo sapiens

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF176
type: RelationshipXref
id: PTHR24356:SF176
db: PANTHER Family
relationship type: By Homology

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot P41799 805
organism: Phaeosphaeria nodorum

DNAI2 isoform 1
type: ProteinReference
xref: PTHR12442:SF7
xref: uniprot A0A2J8KC38 442
organism: Pan troglodytes

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q9RUP1 995
organism: Deinococcus radiodurans

Melanocyte-stimulating hormone receptor
type: ProteinReference
xref: uniprot F7D7Y7 767
xref: PTHR11588:SF43
organism: Macaca mulatta

TATA-box-binding protein 2
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q8TU94 1358
organism: Methanosarcina acetivorans

Calpain 5
type: ProteinReference
xref: PTHR10183:SF402
xref: uniprot F1PB20 124
organism: Canis lupus familiaris

Protein kinase C and casein kinase substrate in neurons protein 1
type: ProteinReference
xref: uniprot G7MRS0 12
xref: PTHR23065:SF16
organism: Macaca mulatta

Glyceraldehyde-3-phosphate dehydrogenase (Fragment)
type: ProteinReference
xref: uniprot B8BQU2 913
organism: Thalassiosira pseudonana

uniprot Q00960 62
type: UnificationXref
id: Q00960
db: uniprot

uniprot P0DH91 1444
type: UnificationXref
id: P0DH91
db: uniprot

PTHR11937:SF201
type: RelationshipXref
id: PTHR11937:SF201
db: PANTHER Family
relationship type: By Homology

uniprot Q6EP31 1285
type: UnificationXref
id: Q6EP31
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P60010 332
organism: Saccharomyces cerevisiae

uniprot H2QAQ0 502
type: UnificationXref
id: H2QAQ0
db: uniprot

uniprot E1C2Q1 628
type: UnificationXref
id: E1C2Q1
db: uniprot

uniprot Q9VAV5 585
type: UnificationXref
id: Q9VAV5
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot F6X9N6 1038
xref: PTHR12644:SF1
organism: Monodelphis domestica

TRANSCRIPTION_LEFT__HTT-RIGHT__HTT-_re76
type: TemplateReaction
product: HTT
xref: TRANSCRIPTION
participant: HTT
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Clathrin light chain A
type: ProteinReference
xref: PTHR10639:SF1
xref: uniprot O08585 661
organism: Mus musculus

uniprot Q92747 1060
type: UnificationXref
id: Q92747
db: uniprot

PTHR24356:SF190
type: RelationshipXref
id: PTHR24356:SF190
db: PANTHER Family
relationship type: By Homology

Cell division cycle 42
type: ProteinReference
xref: uniprot Q28BZ0 1271
organism: Xenopus tropicalis

uniprot F1MX60 679
type: UnificationXref
id: F1MX60
db: uniprot

uniprot Q64691 162
type: UnificationXref
id: Q64691
db: uniprot

CBP
type: ProteinReference
xref: P00777
standard name: CREB binding protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.CBP
comment: ENTITY_REFERENCE_NOTES= Long Name: CREB binding protein Synonym: Synonym not specified Accession: P00777
member entity reference: CREB binding protein
member entity reference: CREB-binding protein
member entity reference: CREB-binding protein isoform a
member entity reference: Histone acetyltransferase p300
member entity reference: Histone acetyltransferase HAC5
member entity reference: Protein cbp-1
member entity reference: Histone acetyltransferase HAC2
member entity reference: Histone acetyltransferase HAC12
member entity reference: Histone acetyltransferase HAC4
member entity reference: Histone acetyltransferase HAC1
member entity reference: E1A binding protein p300
member entity reference: Uncharacterized protein

uniprot P80505 961
type: UnificationXref
id: P80505
db: uniprot

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: uniprot Q6P640 392
xref: PTHR11937:SF176
organism: Xenopus tropicalis

ADP-ribosylation factor-like protein 1
type: ProteinReference
xref: uniprot P38116 1450
xref: PTHR11711:SF41
organism: Saccharomyces cerevisiae

PTHR45732:SF7
type: RelationshipXref
id: PTHR45732:SF7
db: PANTHER Family
relationship type: By Homology

uniprot Q5ZJI7 1056
type: UnificationXref
id: Q5ZJI7
db: uniprot

uniprot G3N3K3 46
type: UnificationXref
id: G3N3K3
db: uniprot

Os05g0106600 protein
type: ProteinReference
xref: PTHR11937:SF464
xref: uniprot Q65XH8 385
organism: Oryza sativa

uniprot A9TBG2 218
type: UnificationXref
id: A9TBG2
db: uniprot

uniprot H3EPN0 1438
type: UnificationXref
id: H3EPN0
db: uniprot

uniprot F6VPX9 1533
type: UnificationXref
id: F6VPX9
db: uniprot

Apoptotic protease-activating factor 1
type: ProteinReference
xref: uniprot O14727 1113
xref: PTHR22845:SF5
organism: Homo sapiens

uniprot E9HCC9 1403
type: UnificationXref
id: E9HCC9
db: uniprot

ncbitaxon 7719 189
type: UnificationXref
id: 7719
db: ncbitaxon

TATA-box-binding protein 3
type: ProteinReference
xref: uniprot Q8TTZ7 1357
xref: PTHR10126:SF42
organism: Methanosarcina acetivorans

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: PTHR48013:SF17
xref: uniprot O14733 1307
organism: Homo sapiens

uniprot E9GER1 750
type: UnificationXref
id: E9GER1
db: uniprot

uniprot P28185 1026
type: UnificationXref
id: P28185
db: uniprot

uniprot F1NRI4 473
type: UnificationXref
id: F1NRI4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Actin-RIGHT__Actin-_r67
controller: Complex (Rab8/FIP-2/ Htt)

uniprot Q9Y6W3 178
type: UnificationXref
id: Q9Y6W3
db: uniprot

Actin s139 a177 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Actin
stoichiometric coefficient: 8.0

uniprot F6WYK8 761
type: UnificationXref
id: F6WYK8
db: uniprot

uniprot B3RX77 230
type: UnificationXref
id: B3RX77
db: uniprot

PARTICIPANT STOICHIOMETRY r23 1737
type: Stoichiometry
physical entity: Calpain
stoichiometric coefficient: 1.0

ADP-ribosylation factor A1E
type: ProteinReference
xref: PTHR11711:SF390
xref: uniprot Q9M1P5 1525
organism: Arabidopsis thaliana

uniprot B7PBG2 232
type: UnificationXref
id: B7PBG2
db: uniprot

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF37
xref: uniprot P61161 339
organism: Mus musculus

uniprot Q9JKY5 1093
type: UnificationXref
id: Q9JKY5
db: uniprot

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF409
xref: uniprot P61160 338
organism: Homo sapiens

Novel protein similar to vertebrate ADP-ribosylation factor 4 (ARF4) (Zgc:77650)
type: ProteinReference
xref: PTHR11711:SF370
xref: uniprot Q6P5M5 1506
organism: Danio rerio

Actin, alpha 2, smooth muscle, aorta
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot Q5M8T9 382
organism: Xenopus tropicalis

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot Q05062 1266
organism: Caenorhabditis elegans

Actin
type: Protein
entity reference: Actin
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot H9XVM3 1439
type: UnificationXref
id: H9XVM3
db: uniprot

PARTICIPANT STOICHIOMETRY r23 1736
type: Stoichiometry
physical entity: Calpain
stoichiometric coefficient: 1.0

uniprot Q12879 68
type: UnificationXref
id: Q12879
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF247
xref: uniprot Q6P5M9 843
organism: Danio rerio

ADP-ribosylation factor-like 4Cb
type: ProteinReference
xref: uniprot Q6P5M7 1507
xref: PTHR11711:SF119
organism: Danio rerio

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q52366 1349
organism: Thermococcus kodakaraensis

uniprot Q78EJ9 164
type: UnificationXref
id: Q78EJ9
db: uniprot

uniprot O88656 1047
type: UnificationXref
id: O88656
db: uniprot

Htt s86 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Htt
stoichiometric coefficient: 1.0

Calpain 6
type: ProteinReference
xref: uniprot F1PB63 125
xref: PTHR10183:SF381
organism: Canis lupus familiaris

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: PTHR10709:SF10
xref: uniprot O88656 1047
organism: Rattus norvegicus

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: PTHR10709:SF10
xref: uniprot Q58CQ2 1054
organism: Bos taurus

uniprot C4M8K6 1220
type: UnificationXref
id: C4M8K6
db: uniprot

Actin-2
type: ProteinReference
xref: uniprot A3C6D7 197
xref: PTHR11937:SF410
organism: Oryza sativa

uniprot B3S5E4 231
type: UnificationXref
id: B3S5E4
db: uniprot

uniprot P69897 813
type: UnificationXref
id: P69897
db: uniprot

PARTICIPANT STOICHIOMETRY r55 1739
type: Stoichiometry
physical entity: GAPDH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r55 1738
type: Stoichiometry
physical entity: Complex (PolyQ Htt/GAPDH)
stoichiometric coefficient: 1.0

Transcription factor Sp1
type: ProteinReference
xref: uniprot Q01714 1125
organism: Rattus norvegicus

uniprot Q9QXU8 582
type: UnificationXref
id: Q9QXU8
db: uniprot

uniprot A0A2R8PX02 672
type: UnificationXref
id: A0A2R8PX02
db: uniprot

uniprot H2Q713 501
type: UnificationXref
id: H2Q713
db: uniprot

DLG4 isoform 1
type: ProteinReference
xref: PTHR23119:SF33
xref: uniprot H2QC23 1077
organism: Pan troglodytes

ncbitaxon 237561 971
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot A0A3P6PCS5 1030
type: UnificationXref
id: A0A3P6PCS5
db: uniprot

uniprot P35438 59
type: UnificationXref
id: P35438
db: uniprot

Chloroflexus aurantiacus
type: BioSource
xref: ncbitaxon 324602 912

uniprot O15511 1045
type: UnificationXref
id: O15511
db: uniprot

uniprot E2R0F7 121
type: UnificationXref
id: E2R0F7
db: uniprot

uniprot W4XKT1 590
type: UnificationXref
id: W4XKT1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11711:SF381
xref: uniprot C3Z3B1 1394
organism: Branchiostoma floridae

uniprot Q553U6 373
type: UnificationXref
id: Q553U6
db: uniprot

PARTICIPANT STOICHIOMETRY r55 1740
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 1.0

PTHR10676:SF242
type: RelationshipXref
id: PTHR10676:SF242
db: PANTHER Family
relationship type: By Homology

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot H2QC53 694
xref: PTHR11447:SF6
organism: Pan troglodytes

Fos protein
type: Protein
entity reference: Fos protein
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

ADP-ribosylation factor-like protein 4D
type: ProteinReference
xref: PTHR11711:SF137
xref: uniprot Q99PE9 1522
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XZ13 244
organism: Branchiostoma floridae

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q94469 988
organism: Dictyostelium discoideum

AP-2 complex subunit alpha
type: ProteinReference
xref: uniprot D3ZUY8 881
xref: PTHR22780:SF33
organism: Rattus norvegicus

Actin-related protein 2/3 complex subunit 1
type: ProteinReference
xref: PTHR10709:SF2
xref: uniprot O96622 1048
organism: Dictyostelium discoideum

Cytochrome c1
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q9FQ96 1203
organism: Chlamydomonas reinhardtii

Glutamate receptor ionotropic, kainate 4
type: ProteinReference
xref: uniprot Q16099 652
xref: PTHR18966:SF171
organism: Homo sapiens

PTHR12442:SF7
type: RelationshipXref
id: PTHR12442:SF7
db: PANTHER Family
relationship type: By Homology

uniprot H2QM47 134
type: UnificationXref
id: H2QM47
db: uniprot

uniprot Q9VRL0 1207
type: UnificationXref
id: Q9VRL0
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF404
xref: uniprot A8XSF1 731
organism: Caenorhabditis briggsae

PTHR23351:SF4
type: RelationshipXref
id: PTHR23351:SF4
db: PANTHER Family
relationship type: By Homology

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot W4XKT1 590
organism: Strongylocentrotus purpuratus

Neural Wiskott-Aldrich syndrome protein
type: ProteinReference
xref: PTHR23202:SF39
xref: uniprot Q91YD9 1072
organism: Mus musculus

Glyceraldehyde-3-phosphate dehydrogenase 2
type: ProteinReference
xref: uniprot O34425 925
organism: Bacillus subtilis

uniprot E1BJ18 120
type: UnificationXref
id: E1BJ18
db: uniprot

uniprot F6UA54 278
type: UnificationXref
id: F6UA54
db: uniprot

uniprot A7SJX9 728
type: UnificationXref
id: A7SJX9
db: uniprot

uniprot Q10DV7 368
type: UnificationXref
id: Q10DV7
db: uniprot

uniprot Q01112 1264
type: UnificationXref
id: Q01112
db: uniprot

uniprot Q5XJ10 974
type: UnificationXref
id: Q5XJ10
db: uniprot

Iron
type: SmallMolecule
cellular location: synapse
comment: SPECIES_TYPE=ION

PTHR10639:SF28
type: RelationshipXref
id: PTHR10639:SF28
db: PANTHER Family
relationship type: By Homology

uniprot F1P0L4 633
type: UnificationXref
id: F1P0L4
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7B5L8 604
xref: PTHR24055:SF172
organism: Ornithorhynchus anatinus

uniprot Q9U2S4 1528
type: UnificationXref
id: Q9U2S4
db: uniprot

uniprot F1PL57 682
type: UnificationXref
id: F1PL57
db: uniprot

uniprot P10984 313
type: UnificationXref
id: P10984
db: uniprot

uniprot P69895 812
type: UnificationXref
id: P69895
db: uniprot

PolyQ Htt
type: Protein
entity reference: PolyQ Htt
feature: PolyQ Htt s5 a6 rs1

uniprot F1MBQ0 468
type: UnificationXref
id: F1MBQ0
db: uniprot

Complex (Rac/GTP)
type: Complex
component stoichiometry: GTP s99 sa48 STOICHIOMETRY ID COMPLEX
component stoichiometry: Rac s96 sa47 STOICHIOMETRY ID COMPLEX
component: GTP
component: Rac
feature: COMPLEX BINDING FEATURE s187 a259 1654
feature: COMPLEX BINDING FEATURE s187 a259 1652
cellular location: synapse

uniprot Q5R1P0 73
type: UnificationXref
id: Q5R1P0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot F7ALP1 285
organism: Monodelphis domestica

uniprot Q9FQ96 1203
type: UnificationXref
id: Q9FQ96
db: uniprot

uniprot P17330 947
type: UnificationXref
id: P17330
db: uniprot

ADP-ribosylation factor-like protein 4A
type: ProteinReference
xref: PTHR11711:SF139
xref: uniprot F7ALP7 1423
organism: Macaca mulatta

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF93
xref: uniprot F1ME41 469
organism: Bos taurus

uniprot B3RQZ1 1392
type: UnificationXref
id: B3RQZ1
db: uniprot

CBP s12 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CBP
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: MLK-2

uniprot Q01097 64
type: UnificationXref
id: Q01097
db: uniprot

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 926

MLK 2 s23 a32 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

TBP s21 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TBP
stoichiometric coefficient: 1.0

Ca2+
type: SmallMolecule
cellular location: mitochondrion
comment: SPECIES_TYPE=ION

STATE_TRANSITION_LEFT__MAPKK4-RIGHT__MAPKK4-_r14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 1684
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 1685
left: MAPKK4
interaction type: STATE_TRANSITION
right: MAPKK4

uniprot A0A1W2WEN5 188
type: UnificationXref
id: A0A1W2WEN5
db: uniprot

PolyQ Htt
type: Complex
component stoichiometry: PolyQ Htt s54 a73 STOICHIOMETRY ID COMPLEX
component: PolyQ Htt
cellular location: nucleus

AP-2 complex subunit alpha
type: ProteinReference
xref: PTHR22780:SF4
xref: uniprot Q22601 894
organism: Caenorhabditis elegans

PolyQ Htt
type: Complex
component stoichiometry: PolyQ Htt s5 a6 STOICHIOMETRY ID COMPLEX
component: PolyQ Htt
cellular location: synapse

PolyQ Htt
type: Complex
component stoichiometry: PolyQ Htt s9 sa2 STOICHIOMETRY ID COMPLEX
component: PolyQ Htt
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa2 1583
cellular location: synapse

uniprot Q803D1 1518
type: UnificationXref
id: Q803D1
db: uniprot

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot Q9TU25 1303
xref: PTHR24072:SF169
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF174
xref: uniprot F6YBQ8 637
organism: Macaca mulatta

Cytoplasmic dynein 2 heavy chain 1
type: ProteinReference
xref: uniprot Q8NCM8 565
xref: PTHR10676:SF352
organism: Homo sapiens

Actin-1
type: ProteinReference
xref: uniprot Q8I4X0 405
xref: PTHR11937:SF387
organism: Plasmodium falciparum

uniprot Q7ZVI3 1293
type: UnificationXref
id: Q7ZVI3
db: uniprot

uniprot E9HEX5 751
type: UnificationXref
id: E9HEX5
db: uniprot

TATA-box-binding protein
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot P13393 1334
organism: Saccharomyces cerevisiae

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF112
xref: uniprot H2QKN9 775
organism: Pan troglodytes

uniprot Q8RFN9 984
type: UnificationXref
id: Q8RFN9
db: uniprot

Tubulin beta-3 chain
type: ProteinReference
xref: uniprot Q13509 817
xref: PTHR11588:SF43
organism: Homo sapiens

uniprot F1PYF1 1226
type: UnificationXref
id: F1PYF1
db: uniprot

uniprot Q38D65 1491
type: UnificationXref
id: Q38D65
db: uniprot

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 929

uniprot F6UDX9 280
type: UnificationXref
id: F6UDX9
db: uniprot

uniprot P42858 1022
type: UnificationXref
id: P42858
db: uniprot

uniprot Q8TD57 567
type: UnificationXref
id: Q8TD57
db: uniprot

uniprot P05412 1129
type: UnificationXref
id: P05412
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__NMDA_receptor_PSD_95__Kainate_receptor_Htt__HAP1_Duo_-_PolyQ_Htt-RIGHT__Complex__PSD_95_PolyQ_Htt_-_r77
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 1690
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 1691
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 1692
left: PolyQ Htt
left: Complex (NMDA receptor/PSD-95/ Kainate receptor/Htt/ HAP1/Duo)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (PSD-95/PolyQ Htt)

uniprot Q75HX0 398
type: UnificationXref
id: Q75HX0
db: uniprot

AGAP010958-PA
type: ProteinReference
xref: uniprot Q7PFI3 1353
xref: PTHR10126:SF42
organism: Anopheles gambiae

uniprot Q4Q4C4 831
type: UnificationXref
id: Q4Q4C4
db: uniprot

uniprot H2R491 99
type: UnificationXref
id: H2R491
db: uniprot

Cytochrome c1 2, heme protein, mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q9FKS5 1202
organism: Arabidopsis thaliana

uniprot E2R9P6 1396
type: UnificationXref
id: E2R9P6
db: uniprot

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 1360

DYNC1H1 isoform 2
type: ProteinReference
xref: PTHR10676:SF314
xref: uniprot K7DEX7 511
organism: Pan troglodytes

uniprot E2R8T7 122
type: UnificationXref
id: E2R8T7
db: uniprot

uniprot F7BFR8 96
type: UnificationXref
id: F7BFR8
db: uniprot

uniprot H2QZJ8 1436
type: UnificationXref
id: H2QZJ8
db: uniprot

TAFII130
type: Protein
entity reference: TAFII130
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa11 1551
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q336M3 1489
type: UnificationXref
id: Q336M3
db: uniprot

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 987

uniprot Q8CFN2 1294
type: UnificationXref
id: Q8CFN2
db: uniprot

uniprot Q5F412 544
type: UnificationXref
id: Q5F412
db: uniprot

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot F7ATP3 688
organism: Ornithorhynchus anatinus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Apoptosis
controller: Caspase 8

uniprot Q22601 894
type: UnificationXref
id: Q22601
db: uniprot

uniprot P39087 646
type: UnificationXref
id: P39087
db: uniprot

uniprot P12456 798
type: UnificationXref
id: P12456
db: uniprot

Calpain-2 catalytic subunit
type: ProteinReference
xref: uniprot O08529 139
xref: PTHR10183:SF268
organism: Mus musculus

uniprot H3EKK6 510
type: UnificationXref
id: H3EKK6
db: uniprot

uniprot Q94231 1521
type: UnificationXref
id: Q94231
db: uniprot

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 211

PARTICIPANT STOICHIOMETRY r71 1704
type: Stoichiometry
physical entity: beta-Tubulin
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r71 1703
type: Stoichiometry
physical entity: beta-Tubulin
stoichiometric coefficient: 1.0

Hip-1
type: Protein
entity reference: Hip-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s65 sa22 1539
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot H2QKN9 775
type: UnificationXref
id: H2QKN9
db: uniprot

Actin-10
type: ProteinReference
xref: uniprot Q54GX7 372
xref: PTHR11937:SF421
organism: Dictyostelium discoideum

Tumor protein p73
type: ProteinReference
xref: uniprot D4AA88 675
xref: PTHR11447:SF21
organism: Rattus norvegicus

c-Jun
type: Protein
entity reference: c-Jun
feature: c Jun s115 sa6 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s115 sa6 1571
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r33 1718
type: Stoichiometry
physical entity: Complex (Fos protein/c-Jun)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r33 1717
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r33 1716
type: Stoichiometry
physical entity: Fos protein
stoichiometric coefficient: 1.0

uniprot P08082 664
type: UnificationXref
id: P08082
db: uniprot

uniprot Q96292 409
type: UnificationXref
id: Q96292
db: uniprot

uniprot Q3ZBU7 826
type: UnificationXref
id: Q3ZBU7
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot A9WBV5 911
organism: Chloroflexus aurantiacus

uniprot Q4QBN6 542
type: UnificationXref
id: Q4QBN6
db: uniprot

GDP s93 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot P62331 1472
type: UnificationXref
id: P62331
db: uniprot

HIP1R isoform 1
type: ProteinReference
xref: uniprot K7CDK7 1090
organism: Pan troglodytes

eco ECO:0000304 426
type: UnificationXref
id: ECO:0000304
db: eco

Rho-related GTP-binding protein RhoQ
type: ProteinReference
xref: uniprot Q8R527 1295
xref: PTHR24072:SF13
organism: Mus musculus

Hip-1
type: Protein
entity reference: Hip-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s81 sa35 1557
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot Q0U5H3 1268
type: UnificationXref
id: Q0U5H3
db: uniprot

PACSIN 1 s77 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PACSIN-1
stoichiometric coefficient: 1.0

Pristionchus pacificus
type: BioSource
xref: ncbitaxon 54126 191

Optineurin
type: ProteinReference
xref: uniprot Q96CV9 1145
organism: Homo sapiens

uniprot A7ETS6 199
type: UnificationXref
id: A7ETS6
db: uniprot

Complex (Sp1/Htt/ TAFII130/TBP)
type: Complex
component stoichiometry: TBP s21 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: Htt s16 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: TAFII130 s20 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Sp1 s15 sa9 STOICHIOMETRY ID COMPLEX
component: TBP
component: Sp1
component: TAFII130
component: Htt
feature: COMPLEX BINDING FEATURE s70 a96 1552
feature: COMPLEX BINDING FEATURE s70 a96 1548
feature: COMPLEX BINDING FEATURE s70 a96 1550
feature: COMPLEX BINDING FEATURE s70 a96 1546
cellular location: nucleus

ADP-ribosylation factor A1B
type: ProteinReference
xref: uniprot Q9LYJ3 1524
xref: PTHR11711:SF383
organism: Arabidopsis thaliana

uniprot Q9I8V1 410
type: UnificationXref
id: Q9I8V1
db: uniprot

uniprot Q8H7U1 857
type: UnificationXref
id: Q8H7U1
db: uniprot

uniprot Q38903 1276
type: UnificationXref
id: Q38903
db: uniprot

TRANSLATION_LEFT__BDNF-RIGHT__BDNF-_re75
type: TemplateReaction
product: BDNF
xref: TRANSLATION
participant: BDNF
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

uniprot Q1JP79 1051
type: UnificationXref
id: Q1JP79
db: uniprot

uniprot P61857 809
type: UnificationXref
id: P61857
db: uniprot

uniprot F1MK42 1225
type: UnificationXref
id: F1MK42
db: uniprot

uniprot Q9Y6G9 589
type: UnificationXref
id: Q9Y6G9
db: uniprot

uniprot Q24418 71
type: UnificationXref
id: Q24418
db: uniprot

uniprot F7E840 769
type: UnificationXref
id: F7E840
db: uniprot

FIP-2
type: ProteinReference
xref: P00772
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.FIP-2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Tumor necrosis factor alpha-induced protein 8
member entity reference: Uncharacterized protein
member entity reference: Optineurin
member entity reference: TNF alpha induced protein 8

uniprot G3MX54 500
type: UnificationXref
id: G3MX54
db: uniprot

Arp2/3 complex
type: Protein
entity reference: Arp2/3 complex
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Calpain 6
type: ProteinReference
xref: uniprot A0A2I3TXK9 114
xref: PTHR10183:SF381
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3XYC6 239
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYC5 238
xref: PTHR11937:SF468
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYC8 241
xref: PTHR11937:SF468
organism: Branchiostoma floridae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PolyQ_Htt-RIGHT__PolyQ_Htt-_r3
controller: Complex (Arfaptin-2/ARF)

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYC7 240
xref: PTHR11937:SF468
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYC2 234
xref: PTHR11937:SF468
organism: Branchiostoma floridae

PTHR10266:SF3
type: RelationshipXref
id: PTHR10266:SF3
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYC4 237
xref: PTHR11937:SF468
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3XYC3 236
organism: Branchiostoma floridae

Actin, alpha 1, skeletal muscle
type: ProteinReference
xref: PTHR11937:SF193
xref: uniprot Q6DIV8 388
organism: Xenopus tropicalis

ADP ribosylation factor-like GTPase 4A
type: ProteinReference
xref: PTHR11711:SF139
xref: uniprot Q6DIV3 1501
organism: Xenopus tropicalis

uniprot O75376 1369
type: UnificationXref
id: O75376
db: uniprot

Mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot F1PBB6 1323
organism: Canis lupus familiaris

Glutamate receptor ionotropic, kainate 2
type: ProteinReference
xref: uniprot P42260 647
xref: PTHR18966:SF38
organism: Rattus norvegicus

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF306
xref: uniprot Q6TYR8 849
organism: Physcomitrella patens

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF306
xref: uniprot Q6TYR7 848
organism: Physcomitrella patens

Glutamate receptor, ionotropic, kainate 1b
type: ProteinReference
xref: uniprot A0A286YAY2 619
xref: PTHR18966:SF36
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR10676:SF314
xref: uniprot F1NKL4 472
organism: Gallus gallus

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 380

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF306
xref: uniprot Q6TYR6 847
organism: Physcomitrella patens

Tubulin beta chain
type: ProteinReference
xref: uniprot Q6TYR5 846
xref: PTHR11588:SF306
organism: Physcomitrella patens

Glutamate receptor ionotropic, kainate 3
type: ProteinReference
xref: PTHR18966:SF174
xref: uniprot P42264 648
organism: Rattus norvegicus

Dynein axonemal heavy chain 8
type: ProteinReference
xref: PTHR10676:SF361
xref: uniprot E2REK9 462
organism: Canis lupus familiaris

uniprot Q6P367 842
type: UnificationXref
id: Q6P367
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Bax-RIGHT__Bax-_re66
control type: ACTIVATION
controller: p53

uniprot H2Q8F7 1238
type: UnificationXref
id: H2Q8F7
db: uniprot

TATA-box-binding protein 1
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot P52653 1342
organism: Entamoeba histolytica

Glutamate ionotropic receptor kainate type subunit 2
type: ProteinReference
xref: PTHR18966:SF38
xref: uniprot F1MG21 631
organism: Bos taurus

uniprot H3FHL0 781
type: UnificationXref
id: H3FHL0
db: uniprot

GAPDH
type: Protein
entity reference: GAPDH
feature: COMPLEX PARTICIPANT BINDING FEATURE s62 sa19 1601
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot A5A6H2 421
type: UnificationXref
id: A5A6H2
db: uniprot

uniprot H3FCG4 299
type: UnificationXref
id: H3FCG4
db: uniprot

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 942

uniprot A0A2I3SB47 1305
type: UnificationXref
id: A0A2I3SB47
db: uniprot

Tubulin beta-2 chain
type: ProteinReference
xref: uniprot P32882 803
xref: PTHR11588:SF375
organism: Gallus gallus

Actin-related protein 2/3 complex subunit 1
type: ProteinReference
xref: uniprot P78774 1050
xref: PTHR10709:SF2
organism: Schizosaccharomyces pombe

Dynein light intermediate chain, isoform A
type: ProteinReference
xref: uniprot Q9VZ20 588
xref: PTHR12688:SF0
organism: Drosophila melanogaster

uniprot P45984 606
type: UnificationXref
id: P45984
db: uniprot

TRANSPORT_LEFT__Complex__PolyQ_Htt_GAPDH_-RIGHT__Complex__PolyQ_Htt_GAPDH_-_r53
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 1744
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 1745
left: Complex (PolyQ Htt/GAPDH)
interaction type: TRANSPORT
right: Complex (PolyQ Htt/GAPDH)

uniprot P84082 1479
type: UnificationXref
id: P84082
db: uniprot

Actin 1
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q6TYS2 394
organism: Physcomitrella patens

uniprot P39086 645
type: UnificationXref
id: P39086
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 235

uniprot F7ATP3 688
type: UnificationXref
id: F7ATP3
db: uniprot

uniprot O89110 1107
type: UnificationXref
id: O89110
db: uniprot

GTP s99 sa48 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__BDNF-RIGHT__BDNF-_re74
type: TemplateReaction
product: BDNF
xref: TRANSCRIPTION
participant: BDNF
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Calpain
type: Protein
entity reference: Calpain
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

NADPH quinone oxidoreductase, putative
type: DnaReference
organism: Deinococcus radiodurans

uniprot Q9M1P5 1525
type: UnificationXref
id: Q9M1P5
db: uniprot

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot P12841 429
organism: Rattus norvegicus

Actin
type: ProteinReference
xref: uniprot A8JAV1 210
xref: PTHR11937:SF387
organism: Chlamydomonas reinhardtii

uniprot P38065 890
type: UnificationXref
id: P38065
db: uniprot

uniprot A8XNZ9 880
type: UnificationXref
id: A8XNZ9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR13808:SF29
xref: uniprot E1B8D6 1002
organism: Bos taurus

HETERODIMER_ASSOCIATION_LEFT__PolyQ_Htt-_GAPDH-RIGHT__PolyQ_Htt-_r56
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 1735
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 1733
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 1734
left: PolyQ Htt
left: GAPDH
interaction type: HETERODIMER_ASSOCIATION
right: PolyQ Htt

uniprot Q9FC43 990
type: UnificationXref
id: Q9FC43
db: uniprot

Protein CBR-ARF-6
type: ProteinReference
xref: uniprot A8WMU9 1383
xref: PTHR11711:SF322
organism: Caenorhabditis briggsae

TATA-box-binding protein
type: ProteinReference
xref: uniprot P32085 1341
xref: PTHR10126:SF42
organism: Caenorhabditis elegans

uniprot A7SCN8 205
type: UnificationXref
id: A7SCN8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYD4 243
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYD3 242
organism: Branchiostoma floridae

Cytochrome c1
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot E2REM0 1188
organism: Canis lupus familiaris

Tubulin beta chain
type: ProteinReference
xref: uniprot W4XKG7 869
xref: PTHR11588:SF314
organism: Strongylocentrotus purpuratus

Calpain
type: Protein
entity reference: Calpain
feature: ACTIVE 84
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

TRUNCATION_LEFT__Pro_caspase_8-RIGHT__Protein_fragment-_Caspase_8-_r59
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 1726
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 1727
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 1725
left: Pro-caspase 8
interaction type: TRUNCATION
right: Caspase 8
right: Protein fragment

uniprot Q2KII9 538
type: UnificationXref
id: Q2KII9
db: uniprot

CAPN3 isoform 4
type: ProteinReference
xref: PTHR10183:SF329
xref: uniprot H2RBT6 135
organism: Pan troglodytes

CAPNS1 isoform 6
type: ProteinReference
xref: PTHR46735:SF1
xref: uniprot A0A2I3SDN3 112
organism: Pan troglodytes

uniprot Q7QII7 1515
type: UnificationXref
id: Q7QII7
db: uniprot

Glutamate receptor ionotropic, NMDA 2A
type: ProteinReference
evidence: Evidence 49
evidence: Evidence 58
evidence: Evidence 54
evidence: Evidence 57
xref: uniprot P35436 56
xref: PTHR18966:SF407
organism: Mus musculus

uniprot F7F210 290
type: UnificationXref
id: F7F210
db: uniprot

PTHR18966:SF174
type: RelationshipXref
id: PTHR18966:SF174
db: PANTHER Family
relationship type: By Homology

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 189

PARTICIPANT STOICHIOMETRY r17 1668
type: Stoichiometry
physical entity: JNK-2
stoichiometric coefficient: 1.0

Dynein intermediate chain 2, axonemal
type: ProteinReference
xref: PTHR12442:SF7
xref: uniprot Q9GZS0 579
organism: Homo sapiens

PTHR18966:SF171
type: RelationshipXref
id: PTHR18966:SF171
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r17 1667
type: Stoichiometry
physical entity: JNK-2
stoichiometric coefficient: 1.0

Histone acetyltransferase HAC2
type: ProteinReference
xref: PTHR13808:SF43
xref: uniprot Q9FYH1 1017
organism: Arabidopsis thaliana

uniprot A1Z8T9 445
type: UnificationXref
id: A1Z8T9
db: uniprot

Protein CBR-TBP-1
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot A8X861 1327
organism: Caenorhabditis briggsae

uniprot Q94124 1297
type: UnificationXref
id: Q94124
db: uniprot

uniprot W4YBZ7 872
type: UnificationXref
id: W4YBZ7
db: uniprot

Huntingtin
type: DnaRegionReference
member entity reference: Huntingtin
member entity reference: Uncharacterized protein
xref: G01530
comment: ENTITY_REFERENCE_NOTES= Long Name: Huntingtin Synonym: Synonym not specified Accession: G01530
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.GENE.GENE.HTT
display name: HTT

Cell division control protein 42
type: ProteinReference
xref: uniprot Q9HF56 1300
organism: Ashbya gossypii

uniprot Q8TCU5 80
type: UnificationXref
id: Q8TCU5
db: uniprot

uniprot Q2T9S0 823
type: UnificationXref
id: Q2T9S0
db: uniprot

ADP-ribosylation factor 1
type: ProteinReference
xref: uniprot P36579 1449
xref: PTHR11711:SF30
organism: Schizosaccharomyces pombe

uniprot A7RVI5 447
type: UnificationXref
id: A7RVI5
db: uniprot

uniprot Q9R0Q6 1063
type: UnificationXref
id: Q9R0Q6
db: uniprot

Dynactin subunit 1
type: ProteinReference
xref: PTHR18916:SF6
xref: uniprot P13496 1316
organism: Drosophila melanogaster

uniprot P31750 1169
type: UnificationXref
id: P31750
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot A7EH60 724
xref: PTHR11588:SF9
organism: Sclerotinia sclerotiorum

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot P9WN83 962
organism: Mycobacterium tuberculosis

GroES-like zinc-binding alcohol dehydrogenase family protein
type: DnaReference
name: Proline dehydrogenase 2, mitochondrial
name: AT4g21580/F18E5_200
organism: Arabidopsis thaliana

uniprot P53492 328
type: UnificationXref
id: P53492
db: uniprot

Caspase 8
type: Protein
entity reference: Caspase 8
feature: ACTIVE 84
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot C3YNF2 456
type: UnificationXref
id: C3YNF2
db: uniprot

uniprot Q96ST3 106
type: UnificationXref
id: Q96ST3
db: uniprot

uniprot Q54GX7 372
type: UnificationXref
id: Q54GX7
db: uniprot

Cytochrome c1, heme protein, mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot P08574 1195
organism: Homo sapiens

uniprot P35439 60
type: UnificationXref
id: P35439
db: uniprot

uniprot Q9HC96 174
type: UnificationXref
id: Q9HC96
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase 2
type: ProteinReference
xref: uniprot P00358 930
organism: Saccharomyces cerevisiae

uniprot Q63100 548
type: UnificationXref
id: Q63100
db: uniprot

uniprot Q7X8A1 980
type: UnificationXref
id: Q7X8A1
db: uniprot

uniprot A0A0B4KHJ4 434
type: UnificationXref
id: A0A0B4KHJ4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NU20 632
xref: PTHR18966:SF38
organism: Gallus gallus

uniprot H2QD50 1432
type: UnificationXref
id: H2QD50
db: uniprot

uniprot B7P8B3 1186
type: UnificationXref
id: B7P8B3
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot P20445 951
organism: Emericella nidulans

TATA-box-binding protein E
type: ProteinReference
xref: PTHR10126:SF42
xref: uniprot Q9HN56 1362
organism: Halobacterium salinarum

Protein CBR-CDC-42
type: ProteinReference
xref: uniprot A8XGW3 1210
organism: Caenorhabditis briggsae

uniprot A0A1D5RI38 1375
type: UnificationXref
id: A0A1D5RI38
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase 1
type: ProteinReference
xref: uniprot P00360 932
organism: Saccharomyces cerevisiae

uniprot A0A3Q1NH21 1154
type: UnificationXref
id: A0A3Q1NH21
db: uniprot

Quinone oxidoreductase
type: DnaReference
xref: PTHR48106:SF8
organism: Neurospora crassa

uniprot Q91ZU9 83
type: UnificationXref
id: Q91ZU9
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r12
controller: Kainate receptor

Mitogen-activated protein kinase kinase kinase
type: ProteinReference
xref: uniprot Q95UN8 1082
organism: Drosophila melanogaster

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P78711 360
organism: Neurospora crassa

Glyceraldehyde-3-phosphate dehydrogenase 3
type: ProteinReference
xref: uniprot P00359 931
organism: Saccharomyces cerevisiae

PTHR10170:SF10
type: RelationshipXref
id: PTHR10170:SF10
db: PANTHER Family
relationship type: By Homology

uniprot B1AS29 625
type: UnificationXref
id: B1AS29
db: uniprot

uniprot P67939 702
type: UnificationXref
id: P67939
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot E2RMT4 1032
xref: PTHR10709:SF10
organism: Canis lupus familiaris

uniprot D6XKS6 1187
type: UnificationXref
id: D6XKS6
db: uniprot

Ras homolog gene family, member G (Rho G)
type: ProteinReference
xref: PTHR24072:SF158
xref: uniprot Q1RMI2 1270
organism: Bos taurus

Tumor protein p73
type: ProteinReference
xref: uniprot O15350 696
xref: PTHR11447:SF21
organism: Homo sapiens

uniprot Q9WTU6 608
type: UnificationXref
id: Q9WTU6
db: uniprot

Rac s92 sa45 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

Dynein heavy chain at 62B
type: ProteinReference
xref: PTHR10676:SF387
xref: uniprot Q7KVA7 554
organism: Drosophila melanogaster

Putative actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A0A0D1DMT3 185
organism: Ustilago maydis

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot A0A2J8JEW8 899
xref: PTHR10836:SF111
organism: Pan troglodytes

c Jun s28 a41 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

BDNF
type: RnaRegion
cellular location: synapse
comment: SPECIES_TYPE=RNA

uniprot K7DBC8 1009
type: UnificationXref
id: K7DBC8
db: uniprot

uniprot P61214 1468
type: UnificationXref
id: P61214
db: uniprot

uniprot F6TUR3 277
type: UnificationXref
id: F6TUR3
db: uniprot

uniprot Q7ZSZ9 1292
type: UnificationXref
id: Q7ZSZ9
db: uniprot

uniprot F6X0U8 487
type: UnificationXref
id: F6X0U8
db: uniprot

uniprot B7PA92 737
type: UnificationXref
id: B7PA92
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12688:SF1
xref: uniprot A0A1D5RCQ6 437
organism: Macaca mulatta

uniprot A0A2A6CRA8 190
type: UnificationXref
id: A0A2A6CRA8
db: uniprot

Actin-42A
type: ProteinReference
xref: uniprot P02572 303
xref: PTHR11937:SF453
organism: Drosophila melanogaster

Actin, larval muscle
type: ProteinReference
xref: PTHR11937:SF397
xref: uniprot P02574 304
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__SEK_1-RIGHT__SEK_1-_r16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 1670
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 1669
left: SEK-1
interaction type: STATE_TRANSITION
right: SEK-1

PTHR10709:SF2
type: RelationshipXref
id: PTHR10709:SF2
db: PANTHER Family
relationship type: By Homology

Protein CBR-ACT-5
type: ProteinReference
xref: uniprot A8XS95 215
xref: PTHR11937:SF359
organism: Caenorhabditis briggsae

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot A7ER45 904
organism: Sclerotinia sclerotiorum

Uncharacterized protein rac1A
type: ProteinReference
xref: uniprot F1A084 1224
organism: Dictyostelium purpureum

PTHR10676:SF318
type: RelationshipXref
id: PTHR10676:SF318
db: PANTHER Family
relationship type: By Homology

uniprot P61212 1466
type: UnificationXref
id: P61212
db: uniprot

PTHR10676:SF310
type: RelationshipXref
id: PTHR10676:SF310
db: PANTHER Family
relationship type: By Homology

Beta-actin-like protein 2
type: ProteinReference
xref: uniprot Q562R1 375
xref: PTHR11937:SF168
organism: Homo sapiens

PTHR10676:SF314
type: RelationshipXref
id: PTHR10676:SF314
db: PANTHER Family
relationship type: By Homology

PTHR10639:SF7
type: RelationshipXref
id: PTHR10639:SF7
db: PANTHER Family
relationship type: By Homology

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot B1N2P0 226
organism: Entamoeba histolytica

Actin-related protein 2/3 complex subunit 1A
type: ProteinReference
xref: uniprot Q9R0Q6 1063
xref: PTHR10709:SF11
organism: Mus musculus

PTHR10639:SF1
type: RelationshipXref
id: PTHR10639:SF1
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5Q9P4 436
type: UnificationXref
id: A0A1D5Q9P4
db: uniprot

uniprot O88456 146
type: UnificationXref
id: O88456
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase 1
type: ProteinReference
xref: uniprot P07486 936
organism: Drosophila melanogaster

uniprot A8XRF4 1385
type: UnificationXref
id: A8XRF4
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase 2
type: ProteinReference
xref: uniprot P07487 937
organism: Drosophila melanogaster

uniprot Q6AY65 1101
type: UnificationXref
id: Q6AY65
db: uniprot

uniprot H2Q5I0 50
type: UnificationXref
id: H2Q5I0
db: uniprot

PTHR11937:SF278
type: RelationshipXref
id: PTHR11937:SF278
db: PANTHER Family
relationship type: By Homology

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 258

PTHR11447:SF16
type: RelationshipXref
id: PTHR11447:SF16
db: PANTHER Family
relationship type: By Homology

uniprot Q95UN8 1082
type: UnificationXref
id: Q95UN8
db: uniprot

ADP-ribosylation factor 1
type: ProteinReference
xref: uniprot O00909 1442
xref: PTHR11711:SF30
organism: Dictyostelium discoideum

uniprot Q9LW74 581
type: UnificationXref
id: Q9LW74
db: uniprot

uniprot Q8CE90 1309
type: UnificationXref
id: Q8CE90
db: uniprot

PTHR11447:SF21
type: RelationshipXref
id: PTHR11447:SF21
db: PANTHER Family
relationship type: By Homology

MAP2K4 isoform 3
type: ProteinReference
xref: PTHR48013:SF20
xref: uniprot H2QCA7 1325
organism: Pan troglodytes

uniprot A8WUE7 28
type: UnificationXref
id: A8WUE7
db: uniprot

uniprot P31751 1170
type: UnificationXref
id: P31751
db: uniprot

Tumor protein 63 (p63)
type: ProteinReference
xref: uniprot E9QG65 677
xref: PTHR11447:SF8
organism: Danio rerio

uniprot P49703 1457
type: UnificationXref
id: P49703
db: uniprot

Htt
type: ProteinReference
xref: P00766
standard name: Huntingtin
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Htt
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Huntingtin Synonym: Synonym not specified Accession: P00766
member entity reference: Huntingtin
member entity reference: Uncharacterized protein

Cytoplasmic dynein 1 light intermediate chain 1
type: ProteinReference
xref: PTHR12688:SF2
xref: uniprot Q9QXU8 582
organism: Rattus norvegicus

uniprot F2Z4N0 269
type: UnificationXref
id: F2Z4N0
db: uniprot

Complex (PolyQ Htt/GAPDH)
type: Complex
component stoichiometry: PolyQ Htt s45 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: GAPDH s60 sa17 STOICHIOMETRY ID COMPLEX
component: GAPDH
component: PolyQ Htt
feature: COMPLEX BINDING FEATURE s94 a120 1594
feature: COMPLEX BINDING FEATURE s94 a120 1596
cellular location: synapse

PTHR11937:SF248
type: RelationshipXref
id: PTHR11937:SF248
db: PANTHER Family
relationship type: By Homology

uniprot F7E2I0 1069
type: UnificationXref
id: F7E2I0
db: uniprot

uniprot P53474 324
type: UnificationXref
id: P53474
db: uniprot

PTHR11937:SF240
type: RelationshipXref
id: PTHR11937:SF240
db: PANTHER Family
relationship type: By Homology

AGAP010834-PA
type: ProteinReference
xref: uniprot Q7QGN5 165
xref: PTHR46143:SF1
organism: Anopheles gambiae

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 49
xref: uniprot P35438 59
xref: PTHR18966:SF377
organism: Mus musculus

TNF alpha induced protein 8
type: ProteinReference
xref: uniprot F7BRR0 1136
organism: Ornithorhynchus anatinus

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 49
xref: uniprot P35439 60
xref: PTHR18966:SF377
organism: Rattus norvegicus

GRIN2B isoform 3
type: ProteinReference
evidence: Evidence 25
evidence: Evidence 22
xref: uniprot H2Q5I0 50
xref: PTHR18966:SF382
organism: Pan troglodytes

Tubulin beta-2 chain
type: ProteinReference
xref: PTHR11588:SF325
xref: uniprot Q56YW9 836
organism: Arabidopsis thaliana

uniprot A0A2I3RZ29 439
type: UnificationXref
id: A0A2I3RZ29
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF279
xref: uniprot H3FHL1 782
organism: Pristionchus pacificus

Tubulin beta chain
type: ProteinReference
xref: uniprot H3FHL0 781
xref: PTHR11588:SF293
organism: Pristionchus pacificus

uniprot A0A1D5QAU9 1320
type: UnificationXref
id: A0A1D5QAU9
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot H3FHK9 780
xref: PTHR11588:SF293
organism: Pristionchus pacificus

PTHR24072:SF13
type: RelationshipXref
id: PTHR24072:SF13
db: PANTHER Family
relationship type: By Homology

PolyQ Htt s13 sa8 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

HTT
type: DnaRegion
entity reference: Huntingtin
cellular location: synapse
comment: SPECIES_TYPE=GENE

uniprot A0A2K3D1N8 443
type: UnificationXref
id: A0A2K3D1N8
db: uniprot

uniprot W4YEV4 873
type: UnificationXref
id: W4YEV4
db: uniprot

Calpain-5
type: ProteinReference
xref: uniprot Q8R4C0 166
xref: PTHR10183:SF402
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR10676:SF361
xref: uniprot F7E3R0 494
organism: Macaca mulatta

uniprot W4Y969 416
type: UnificationXref
id: W4Y969
db: uniprot

PTHR24072:SF17
type: RelationshipXref
id: PTHR24072:SF17
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPKK7-RIGHT__MAPKK7-_r15
controller: MLK-2

Tubulin beta chain
type: ProteinReference
xref: uniprot P07437 789
xref: PTHR11588:SF61
organism: Homo sapiens

uniprot P92978 1263
type: UnificationXref
id: P92978
db: uniprot

uniprot Q9LFJ7 1523
type: UnificationXref
id: Q9LFJ7
db: uniprot

uniprot F6RFW8 274
type: UnificationXref
id: F6RFW8
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Calpain-RIGHT__Calpain-_r23
controller: Ca2+

uniprot Q8MKI5 1152
type: UnificationXref
id: Q8MKI5
db: uniprot

PTHR10836:SF111
type: RelationshipXref
id: PTHR10836:SF111
db: PANTHER Family
relationship type: By Homology

Ca2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

Uncharacterized protein
type: DnaReference
xref: PTHR44054:SF1
organism: Macaca mulatta

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot C3Y2F5 742
organism: Branchiostoma floridae

uniprot Q7QBD1 560
type: UnificationXref
id: Q7QBD1
db: uniprot

uniprot E2QYC2 746
type: UnificationXref
id: E2QYC2
db: uniprot

uniprot Q9HZK4 992
type: UnificationXref
id: Q9HZK4
db: uniprot

uniprot F7BCN5 493
type: UnificationXref
id: F7BCN5
db: uniprot

CRYZ isoform 1
type: DnaReference
xref: PTHR44154:SF1
organism: Pan troglodytes

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Pro_caspase_8-RIGHT__Protein_fragment-_Caspase_8-_r59
controller: Complex (Hip-1/Hippi)

uniprot O80856 1046
type: UnificationXref
id: O80856
db: uniprot

Apaf-1
type: ProteinReference
xref: P00768
standard name: Apoptotic protease activating factor-1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Apoptotic protease activating factor-1 Synonym: Synonym not specified Accession: P00768
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Apaf-1
member entity reference: Apoptotic protease-activating factor 1

Glyceraldehyde-3-phosphate dehydrogenase GAPA2, chloroplastic
type: ProteinReference
xref: uniprot Q9LPW0 993
organism: Arabidopsis thaliana

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot P02557 785
organism: Saccharomyces cerevisiae

uniprot W4X9L8 867
type: UnificationXref
id: W4X9L8
db: uniprot

Actin, muscle
type: ProteinReference
xref: uniprot W4XTP5 415
xref: PTHR11937:SF359
organism: Strongylocentrotus purpuratus

PSD 95 s10 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PSD-95
stoichiometric coefficient: 1.0

Tubulin beta-8 chain
type: ProteinReference
xref: PTHR11588:SF55
xref: uniprot Q8WP14 858
organism: Pan troglodytes

uniprot Q7L576 707
type: UnificationXref
id: Q7L576
db: uniprot

uniprot Q62698 546
type: UnificationXref
id: Q62698
db: uniprot

uniprot O14556 924
type: UnificationXref
id: O14556
db: uniprot

PARTICIPANT STOICHIOMETRY r79 1678
type: Stoichiometry
physical entity: Duo
stoichiometric coefficient: 1.0

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot P62999 1258
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r79 1677
type: Stoichiometry
physical entity: Complex (PSD-95/PolyQ Htt)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r79 1676
type: Stoichiometry
physical entity: Complex (NMDA receptor/PSD-95/ Kainate receptor/Htt/ HAP1/Duo)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r79 1679
type: Stoichiometry
physical entity: NMDA receptor
stoichiometric coefficient: 1.0

Calpain-8
type: ProteinReference
xref: uniprot Q78EJ9 164
xref: PTHR10183:SF374
organism: Rattus norvegicus

Tubulin beta chain
type: ProteinReference
xref: uniprot Q6PE34 845
xref: PTHR11588:SF247
organism: Danio rerio

ADP-ribosylation factor 2
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot Q8BSL7 1519
organism: Mus musculus

uniprot Q10943 1485
type: UnificationXref
id: Q10943
db: uniprot

Tumor protein 63 (p63)
type: ProteinReference
xref: uniprot F1PL57 682
xref: PTHR11447:SF8
organism: Canis lupus familiaris

beta-Tubulin
type: ProteinReference
xref: P00790
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: beta-Tubulin Synonym: Synonym not specified Accession: P00790
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC._beta_-Tubulin
member entity reference: Tubulin beta chain
member entity reference: Tubulin beta-1 chain
member entity reference: Tubulin beta-3 chain
member entity reference: Tubulin beta-2 chain
member entity reference: Tubulin beta-2A chain
member entity reference: Probable tubulin beta chain CG32396
member entity reference: Tubulin beta-5 chain
member entity reference: Tubulin beta-8 chain
member entity reference: Tubulin beta-4 chain
member entity reference: Tubulin beta-4B chain
member entity reference: Tubulin beta-6 chain
member entity reference: Tubulin beta-4A chain
member entity reference: Tubulin beta 3 class III
member entity reference: Tubulin beta-7 chain
member entity reference: Tubulin beta-2B chain
member entity reference: Uncharacterized protein

uniprot F6ZPQ4 282
type: UnificationXref
id: F6ZPQ4
db: uniprot

Arfaptin-2
type: ProteinReference
xref: PTHR12141:SF3
xref: uniprot P53365 1099
organism: Homo sapiens

uniprot G5EF01 774
type: UnificationXref
id: G5EF01
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10676:SF314
xref: uniprot A0A3Q1NEU9 444
organism: Bos taurus

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot P17721 949
organism: Thermotoga maritima

uniprot P61204 1460
type: UnificationXref
id: P61204
db: uniprot

uniprot A8WS33 213
type: UnificationXref
id: A8WS33
db: uniprot

uniprot Q7ZVF9 402
type: UnificationXref
id: Q7ZVF9
db: uniprot

Actin A
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q38E94 369
organism: Trypanosoma brucei

Tubulin beta-1 chain
type: ProteinReference
xref: PTHR11588:SF112
xref: uniprot Q9H4B7 865
organism: Homo sapiens

uniprot Q75BP6 850
type: UnificationXref
id: Q75BP6
db: uniprot

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P60766 1255
organism: Mus musculus

uniprot P53497 330
type: UnificationXref
id: P53497
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q9CPW4 1062
xref: PTHR12644:SF1
organism: Mus musculus

uniprot F1P476 266
type: UnificationXref
id: F1P476
db: uniprot

ADP-ribosylation factor 6
type: ProteinReference
xref: PTHR11711:SF379
xref: uniprot F6RLV0 1413
organism: Macaca mulatta

ADP-ribosylation factor (Broad)
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot Q5BEA4 1497
organism: Emericella nidulans

Uncharacterized protein
type: DnaReference
xref: PTHR10170:SF10
organism: Macaca mulatta

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF253
xref: uniprot G2HGK8 773
organism: Pan troglodytes

uniprot Q9LYJ3 1524
type: UnificationXref
id: Q9LYJ3
db: uniprot

Calpain-6
type: ProteinReference
xref: uniprot O88501 147
xref: PTHR10183:SF381
organism: Rattus norvegicus

uniprot Q6LC82 1287
type: UnificationXref
id: Q6LC82
db: uniprot

uniprot O13270 1332
type: UnificationXref
id: O13270
db: uniprot

Glutamate receptor ionotropic, kainate 5
type: ProteinReference
xref: uniprot Q63273 658
xref: PTHR18966:SF351
organism: Rattus norvegicus

uniprot Q7YTV5 401
type: UnificationXref
id: Q7YTV5
db: uniprot

uniprot F2Z4N8 271
type: UnificationXref
id: F2Z4N8
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF112
xref: uniprot F6XQ37 762
organism: Macaca mulatta

uniprot Q8BFZ3 404
type: UnificationXref
id: Q8BFZ3
db: uniprot

uniprot F6QP11 1162
type: UnificationXref
id: F6QP11
db: uniprot

uniprot Q9JJL4 1301
type: UnificationXref
id: Q9JJL4
db: uniprot

uniprot H2Q943 296
type: UnificationXref
id: H2Q943
db: uniprot

uniprot Q6TYR5 846
type: UnificationXref
id: Q6TYR5
db: uniprot

uniprot F6WDB9 484
type: UnificationXref
id: F6WDB9
db: uniprot

uniprot F7GWQ8 1234
type: UnificationXref
id: F7GWQ8
db: uniprot

uniprot A9TVP1 220
type: UnificationXref
id: A9TVP1
db: uniprot

uniprot F4HXI4 1409
type: UnificationXref
id: F4HXI4
db: uniprot

eco ECO:0000303 1326
type: UnificationXref
id: ECO:0000303
db: eco

Cytoplasmic dynein 1 light intermediate chain 1
type: ProteinReference
xref: PTHR12688:SF2
xref: uniprot Q90828 572
organism: Gallus gallus

uniprot Q7PXZ5 557
type: UnificationXref
id: Q7PXZ5
db: uniprot

uniprot Q24560 820
type: UnificationXref
id: Q24560
db: uniprot

Cytochrome c
type: ProteinReference
xref: P00785
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Cytochrome c Synonym: Synonym not specified Accession: P00785
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Cytochrome c
member entity reference: Cytochrome c1, isoform A
member entity reference: Probable cytochrome c1
member entity reference: Cytochrome b/c1
member entity reference: Cytochrome c1 2, heme protein, mitochondrial
member entity reference: Uncharacterized protein
member entity reference: CYC1 isoform 2
member entity reference: Cytochrome c1
member entity reference: Cytochrome c1, heme protein, mitochondrial
member entity reference: Os01g0935700 protein
member entity reference: Protein CBR-CYC-1
member entity reference: Os05g0301700 protein
member entity reference: AT13706p
member entity reference: Cytochrome c1, putative
member entity reference: Cytochrome c1 1, heme protein, mitochondrial
member entity reference: Putative cytochrome c1, heme protein,mitochondrial
member entity reference: CYtochrome C

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 406

Calpain-1 catalytic subunit
type: ProteinReference
xref: uniprot A0A452DJ01 115
xref: PTHR10183:SF284
organism: Bos taurus

uniprot Q6GL60 1286
type: UnificationXref
id: Q6GL60
db: uniprot

BDNF
type: ProteinReference
xref: P00795
standard name: Brain-derived neurotrophic factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.BDNF
comment: ENTITY_REFERENCE_NOTES= Long Name: Brain-derived neurotrophic factor Synonym: Synonym not specified Accession: P00795
member entity reference: Brain-derived neurotrophic factor
member entity reference: Brain-derived neurotrophic factor (Fragment)

uniprot H2QDI5 503
type: UnificationXref
id: H2QDI5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EQF1 1313
xref: PTHR18916:SF6
organism: Monodelphis domestica

Rho-related GTP-binding protein RhoJ
type: ProteinReference
xref: PTHR24072:SF17
xref: uniprot Q9H4E5 1299
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPKK4-RIGHT__MAPKK4-_r14
controller: MLK-2

Cytoplasmic dynein 1 light intermediate chain 2
type: ProteinReference
xref: PTHR12688:SF1
xref: uniprot Q62698 546
organism: Rattus norvegicus

uniprot Q0III3 530
type: UnificationXref
id: Q0III3
db: uniprot

Apoptotic protease-activating factor 1
type: ProteinReference
xref: PTHR22845:SF5
xref: uniprot F6U0K7 1111
organism: Macaca mulatta

Actin alpha 1, skeletal muscle a
type: ProteinReference
xref: PTHR11937:SF416
xref: uniprot F1QUN8 267
organism: Danio rerio

Cell division control protein 42
type: ProteinReference
xref: uniprot P19073 1245
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r28 1723
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r28 1724
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot D3ZXN9 1365
type: UnificationXref
id: D3ZXN9
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q93J08 986
organism: Streptomyces coelicolor

uniprot O08585 661
type: UnificationXref
id: O08585
db: uniprot

uniprot Q27896 1344
type: UnificationXref
id: Q27896
db: uniprot

Protein CBR-NMR-1
type: ProteinReference
evidence: Evidence 22
xref: uniprot A8WUE7 28
xref: PTHR18966:SF377
organism: Caenorhabditis briggsae

Complex (Hip-1/Hippi)
type: Complex
component stoichiometry: Hippi s66 sa23 STOICHIOMETRY ID COMPLEX
component stoichiometry: Hip 1 s65 sa22 STOICHIOMETRY ID COMPLEX
component: Hippi
component: Hip-1
feature: COMPLEX BINDING FEATURE s106 a139 1540
feature: COMPLEX BINDING FEATURE s106 a139 1538
cellular location: synapse

uniprot P63261 346
type: UnificationXref
id: P63261
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase 1
type: ProteinReference
xref: uniprot P04970 935
organism: Caenorhabditis elegans

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r11
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 1697
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 1698
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r12
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 1695
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 1696
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

uniprot P26355 1338
type: UnificationXref
id: P26355
db: uniprot

Clathrin light chain A
type: ProteinReference
xref: PTHR10639:SF1
xref: uniprot P04973 662
organism: Bos taurus

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot Q5R1X3 383
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot E9HCC9 1403
xref: PTHR11711:SF322
organism: Daphnia pulex

Calpain-1 catalytic subunit
type: ProteinReference
xref: uniprot P97571 155
xref: PTHR10183:SF284
organism: Rattus norvegicus

uniprot C3ZHN4 250
type: UnificationXref
id: C3ZHN4
db: uniprot

Clathrin light chain B
type: ProteinReference
xref: PTHR10639:SF28
xref: uniprot P04975 663
organism: Bos taurus

Dynein light chain
type: ProteinReference
xref: uniprot W4XLU7 591
xref: PTHR11886:SF2
organism: Strongylocentrotus purpuratus

uniprot H2QJ64 504
type: UnificationXref
id: H2QJ64
db: uniprot

Sin3A, isoform G
type: ProteinReference
xref: uniprot A0A0B4K765 85
xref: PTHR12346:SF0
organism: Drosophila melanogaster

uniprot P63259 344
type: UnificationXref
id: P63259
db: uniprot

uniprot E9HDF7 1404
type: UnificationXref
id: E9HDF7
db: uniprot

uniprot P41937 806
type: UnificationXref
id: P41937
db: uniprot

Glutamate receptor ionotropic, NMDA 3A
type: ProteinReference
evidence: Evidence 49
evidence: Evidence 81
xref: PTHR18966:SF397
xref: uniprot Q8TCU5 80
organism: Homo sapiens

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: PTHR10709:SF10
xref: uniprot O15143 1044
organism: Homo sapiens

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot F6PVY4 1034
xref: PTHR10709:SF11
organism: Macaca mulatta

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot Q8CFN2 1294
organism: Rattus norvegicus

PTHR11588:SF100
type: RelationshipXref
id: PTHR11588:SF100
db: PANTHER Family
relationship type: By Homology

uniprot E2RNQ0 1399
type: UnificationXref
id: E2RNQ0
db: uniprot

uniprot Q60934 656
type: UnificationXref
id: Q60934
db: uniprot

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF37
xref: uniprot Q5M7U6 381
organism: Rattus norvegicus

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF247
xref: uniprot A0A1D5QYU3 718
organism: Macaca mulatta

ncbitaxon 9031 36
type: UnificationXref
id: 9031
db: ncbitaxon

Synaptic vesicle membrane protein VAT-1 homolog
type: DnaReference
xref: PTHR44054:SF1
organism: Danio rerio

PTHR11588:SF112
type: RelationshipXref
id: PTHR11588:SF112
db: PANTHER Family
relationship type: By Homology

uniprot Q5SQX6 705
type: UnificationXref
id: Q5SQX6
db: uniprot

uniprot Q5TUD8 545
type: UnificationXref
id: Q5TUD8
db: uniprot

uniprot H2KNE6 293
type: UnificationXref
id: H2KNE6
db: uniprot

PTHR11588:SF116
type: RelationshipXref
id: PTHR11588:SF116
db: PANTHER Family
relationship type: By Homology

Cytoplasmic dynein 1 light intermediate chain 2
type: ProteinReference
xref: uniprot Q6PDL0 552
xref: PTHR12688:SF1
organism: Mus musculus

Optineurin
type: ProteinReference
xref: uniprot Q8R5M4 1143
organism: Rattus norvegicus

SIN3 transcription regulator family member B
type: ProteinReference
xref: uniprot E1BGW5 87
xref: PTHR12346:SF1
organism: Bos taurus

Brain-derived neurotrophic factor
type: ProteinReference
xref: uniprot Q6NZ01 600
xref: PTHR11589:SF3
organism: Danio rerio

Rac
type: Protein
entity reference: Rac
feature: COMPLEX PARTICIPANT BINDING FEATURE s92 sa45 1543
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

ADP-ribosylation factor 1, putative
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot C4LXL1 1395
organism: Entamoeba histolytica

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF171
xref: uniprot A0A1D5R2U8 618
organism: Macaca mulatta

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P49186 607
xref: PTHR24055:SF172
organism: Rattus norvegicus

ADP-ribosylation factor-like 4D
type: ProteinReference
xref: PTHR11711:SF137
xref: uniprot H2QD50 1432
organism: Pan troglodytes

Truncated Htt
type: Complex
component stoichiometry: Truncated Htt s76 a102 STOICHIOMETRY ID COMPLEX
component: Truncated Htt
cellular location: synapse

Dynein cytoplasmic 2 heavy chain 1
type: ProteinReference
xref: uniprot A0A2I3SL91 441
xref: PTHR10676:SF352
organism: Pan troglodytes

Truncated Htt
type: Protein
entity reference: Truncated Htt

Arfaptin-2
type: ProteinReference
xref: P00793
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Arfaptin-2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: ADP-ribosylation factor-interacting protein 2
member entity reference: Uncharacterized protein
member entity reference: Arfaptin-2
member entity reference: ADP ribosylation factor interacting protein 2

PARTICIPANT STOICHIOMETRY r79 1680
type: Stoichiometry
physical entity: Kainate receptor
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r79 1681
type: Stoichiometry
physical entity: Complex (Htt/HAP1)
stoichiometric coefficient: 1.0

uniprot E1BW56 676
type: UnificationXref
id: E1BW56
db: uniprot

uniprot F6WV79 603
type: UnificationXref
id: F6WV79
db: uniprot

DYNC1LI1 isoform 1
type: ProteinReference
xref: PTHR12688:SF2
xref: uniprot H2QM89 505
organism: Pan troglodytes

Calpain-1 catalytic subunit
type: ProteinReference
xref: uniprot P07384 150
xref: PTHR10183:SF284
organism: Homo sapiens

uniprot Q78P75 553
type: UnificationXref
id: Q78P75
db: uniprot

uniprot F7CGM4 766
type: UnificationXref
id: F7CGM4
db: uniprot

uniprot F7G487 922
type: UnificationXref
id: F7G487
db: uniprot

Huntingtin
type: ProteinReference
xref: uniprot P51111 1024
xref: PTHR10170:SF10
organism: Rattus norvegicus

Glutamate ionotropic receptor NMDA type subunit 3A
type: ProteinReference
evidence: Evidence 27
evidence: Evidence 22
xref: PTHR18966:SF397
xref: uniprot E2QUL1 31
organism: Canis lupus familiaris

uniprot P04970 935
type: UnificationXref
id: P04970
db: uniprot

uniprot H2QLS0 1008
type: UnificationXref
id: H2QLS0
db: uniprot

Ras homolog family member G
type: ProteinReference
xref: uniprot Q32PX6 1273
xref: PTHR24072:SF158
organism: Rattus norvegicus

uniprot Q9UVF3 414
type: UnificationXref
id: Q9UVF3
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot F6ZCX3 763
xref: PTHR11588:SF112
organism: Monodelphis domestica

uniprot O08529 139
type: UnificationXref
id: O08529
db: uniprot

uniprot H3FHK9 780
type: UnificationXref
id: H3FHK9
db: uniprot

uniprot F4NUL6 756
type: UnificationXref
id: F4NUL6
db: uniprot

PTHR10183:SF402
type: RelationshipXref
id: PTHR10183:SF402
db: PANTHER Family
relationship type: By Homology

Hydroxyproline dehydrogenase
type: DnaReference
organism: Rattus norvegicus

uniprot H2RD22 1331
type: UnificationXref
id: H2RD22
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot W4YBZ7 872
xref: PTHR11588:SF9
organism: Strongylocentrotus purpuratus

Brain-derived neurotrophic factor
type: ProteinReference
xref: uniprot Q5IS78 599
xref: PTHR11589:SF3
organism: Pan troglodytes

Proline oxidase
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Os01g0935700 protein
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q942X6 1201
organism: Oryza sativa

Caspase 6
type: ProteinReference
xref: uniprot F6R1R1 1117
xref: PTHR10454:SF206
organism: Xenopus tropicalis

Tumor protein p53 inducible protein 3
type: DnaRegionReference
member entity reference: Synaptic vesicle membrane protein VAT-1 homolog
member entity reference: Quinone oxidoreductase 1
member entity reference: Putative quinone oxidoreductase
member entity reference: Quinone oxidoreductase
member entity reference: NADPH quinone oxidoreductase, putative
member entity reference: Putative oxidoreductase
member entity reference: Uncharacterized protein
member entity reference: Tumor protein p53 inducible protein 3
member entity reference: Vesicle amine transport protein 1 homolog (T. californica)-like
member entity reference: Synaptic vesicle membrane protein VAT-1 homolog-like
member entity reference: Zeta-crystallin
member entity reference: Quinone oxidoreductase PIG3
member entity reference: Os02g0805600 protein
member entity reference: Probable quinone oxidoreductase
member entity reference: TP53I3 isoform 2
member entity reference: Os10g0561100 protein
member entity reference: Quinone oxidoreductase PIG3 isoform 1
member entity reference: Vesicle amine transport 1 like
member entity reference: VAT1 isoform 3
member entity reference: Vesicle amine transport 1
member entity reference: CRYZ isoform 1
member entity reference: GroES-like zinc-binding alcohol dehydrogenase family protein
member entity reference: Glr2859 protein
member entity reference: Gll1949 protein
member entity reference: NADPH:quinone reductase
xref: G01535
comment: ENTITY_REFERENCE_NOTES= Long Name: Tumor protein p53 inducible protein 3 Synonym: Synonym not specified Accession: G01535
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.GENE.GENE.PIG3
display name: PIG3

Rho-related GTP-binding protein RhoJ
type: ProteinReference
xref: PTHR24072:SF17
xref: uniprot Q9ER71 1298
organism: Mus musculus

STATE_TRANSITION_LEFT__Actin-RIGHT__Actin-_r67
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 1712
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 1713
left: Actin
interaction type: STATE_TRANSITION
right: Actin

uniprot P84080 1477
type: UnificationXref
id: P84080
db: uniprot

AP-2 complex subunit alpha-2
type: ProteinReference
xref: PTHR22780:SF4
xref: uniprot Q86KI1 895
organism: Dictyostelium discoideum

uniprot P61750 1469
type: UnificationXref
id: P61750
db: uniprot

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P31751 1170
organism: Homo sapiens

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q9FC43 990
organism: Streptomyces coelicolor

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31750 1169
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot E9H3D5 1402
xref: PTHR11711:SF381
organism: Daphnia pulex

Bos taurus
type: BioSource
xref: ncbitaxon 9913 7

uniprot P08841 790
type: UnificationXref
id: P08841
db: uniprot

uniprot F7BZM9 1039
type: UnificationXref
id: F7BZM9
db: uniprot

Cytochrome b/c1
type: ProteinReference
xref: PTHR19271:SF16
xref: uniprot P51131 1196
organism: Bradyrhizobium diazoefficiens

uniprot Q7Q319 559
type: UnificationXref
id: Q7Q319
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot H3F5B4 298
xref: PTHR11937:SF359
organism: Pristionchus pacificus

uniprot A0A1D5QLX3 109
type: UnificationXref
id: A0A1D5QLX3
db: uniprot

uniprot P34148 1250
type: UnificationXref
id: P34148
db: uniprot

uniprot Q9DCM4 578
type: UnificationXref
id: Q9DCM4
db: uniprot

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31749 1168
organism: Homo sapiens

uniprot P17081 1244
type: UnificationXref
id: P17081
db: uniprot

uniprot A2GA05 903
type: UnificationXref
id: A2GA05
db: uniprot

ADP-ribosylation factor 2
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot Q6NYD8 1504
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r39 1705
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q7YTV5 401
organism: Trichoplax adhaerens

PARTICIPANT STOICHIOMETRY r39 1706
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

uniprot E9HGF5 261
type: UnificationXref
id: E9HGF5
db: uniprot

PTHR10676:SF36
type: RelationshipXref
id: PTHR10676:SF36
db: PANTHER Family
relationship type: By Homology

HAP1
type: ProteinReference
xref: P00762
standard name: Huntingtin's associated protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.HAP1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Huntingtin-associated protein 1
member entity reference: Huntingtin associated protein 1

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__Actin-RIGHT__Actin-_r67
controller: Complex (Rac/GTP)

Actin
type: ProteinReference
xref: P00807
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Actin
comment: ENTITY_REFERENCE_NOTES= Long Name: Actin Synonym: F-actin Accession: P00807
member entity reference: Actin, cytoplasmic 2
member entity reference: Predicted protein
member entity reference: Uncharacterized protein
member entity reference: Major actin
member entity reference: Actin, gamma
member entity reference: Actin-related protein 3
member entity reference: Actin, alpha skeletal muscle
member entity reference: Actin-12
member entity reference: Actin, cytoplasmic 1
member entity reference: Actin
member entity reference: ACTA1 isoform 1
member entity reference: Actin-2
member entity reference: Protein CBG02167
member entity reference: Actin, aortic smooth muscle
member entity reference: Putative actin-9
member entity reference: Putative actin
member entity reference: Actin related protein
member entity reference: Actin-related protein 2
member entity reference: Beta-actin-like protein 2
member entity reference: actin, muscle-like
member entity reference: Actin-3
member entity reference: Actin, gamma-enteric smooth muscle
member entity reference: Actin, alpha sarcomeric/skeletal
member entity reference: actin, muscle
member entity reference: Actin, alpha, cardiac muscle 1
member entity reference: Actin, beta like 2
member entity reference: Actin, alpha 2, smooth muscle, aorta
member entity reference: Actin-42A
member entity reference: Actin, cytoskeletal 3A
member entity reference: Os12g0163700 protein
member entity reference: Actin-1
member entity reference: Actin-57B
member entity reference: Actin, gamma 2, smooth muscle, enteric
member entity reference: Actin-87E
member entity reference: Putative actin-22
member entity reference: ACTC1 isoform 1
member entity reference: Actin, larval muscle
member entity reference: Actin, cytoskeletal 3B
member entity reference: Actin beta
member entity reference: Actin A
member entity reference: Actin-7
member entity reference: Actin, alpha cardiac muscle 1
member entity reference: Putative actin-5

Calpain-2 catalytic subunit
type: ProteinReference
xref: uniprot Q27971 160
xref: PTHR10183:SF268
organism: Bos taurus

uniprot P17426 887
type: UnificationXref
id: P17426
db: uniprot

E1A binding protein p300
type: ProteinReference
xref: PTHR13808:SF29
xref: uniprot H2QLS0 1008
organism: Pan troglodytes

uniprot Q4QRB4 835
type: UnificationXref
id: Q4QRB4
db: uniprot

uniprot O95379 1139
type: UnificationXref
id: O95379
db: uniprot

PolyQ Htt s11 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 1.0

ADP-ribosylation factor
type: ProteinReference
xref: uniprot P0CM16 1443
xref: PTHR11711:SF30
organism: Cryptococcus neoformans

GTP
type: SmallMolecule
cellular location: synapse
comment: SPECIES_TYPE=ION

uniprot Q7KVA7 554
type: UnificationXref
id: Q7KVA7
db: uniprot

uniprot Q5BL39 837
type: UnificationXref
id: Q5BL39
db: uniprot

Dynein heavy chain 8, axonemal
type: ProteinReference
xref: PTHR10676:SF361
xref: uniprot Q91XQ0 573
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF171
xref: uniprot F7FB74 641
organism: Monodelphis domestica

MAPKK7
type: ProteinReference
xref: P00784
standard name: Mitogen activated protein kinase kinase 7
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Mitogen activated protein kinase kinase 7 Synonym: MKK7 Accession: P00784
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.MAPKK7
member entity reference: Dual specificity mitogen-activated protein kinase kinase 7
member entity reference: Mitogen-activated protein kinase kinase 7

Huntingtin associated protein 1
type: ProteinReference
xref: uniprot H2QD01 609
xref: PTHR15751:SF14
organism: Pan troglodytes

Ras-related protein Rab-8A
type: ProteinReference
xref: uniprot P61006 1029
organism: Homo sapiens

Duo
type: ProteinReference
xref: P00773
standard name: Huntingtin-associated protein interacting protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Duo
comment: ENTITY_REFERENCE_NOTES= Long Name: Huntingtin-associated protein interacting protein Synonym: Kalirin Accession: P00773
member entity reference: Kalirin
member entity reference: Kalirin RhoGEF kinase
member entity reference: Uncharacterized protein

uniprot E1BMG2 459
type: UnificationXref
id: E1BMG2
db: uniprot

Cytoplasmic FMR1-interacting protein
type: ProteinReference
xref: uniprot F1MX60 679
organism: Bos taurus

Glutamate receptor ionotropic, kainate 4
type: ProteinReference
xref: uniprot Q5IS46 655
xref: PTHR18966:SF171
organism: Pan troglodytes

uniprot Q28J03 1487
type: UnificationXref
id: Q28J03
db: uniprot

CAPN7 isoform 3
type: ProteinReference
xref: uniprot H2QM47 134
xref: PTHR46143:SF1
organism: Pan troglodytes

CREB binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot F1MD32 1003
organism: Bos taurus

uniprot E9GYE9 1221
type: UnificationXref
id: E9GYE9
db: uniprot

uniprot A0A0D1DMT3 185
type: UnificationXref
id: A0A0D1DMT3
db: uniprot

Tumor necrosis factor alpha-induced protein 8
type: ProteinReference
xref: uniprot Q5ZI78 1140
organism: Gallus gallus

Protein CBR-ARF-3
type: ProteinReference
xref: uniprot A8XRF4 1385
xref: PTHR11711:SF375
organism: Caenorhabditis briggsae

Actin, gamma
type: ProteinReference
xref: uniprot P20359 320
xref: PTHR11937:SF387
organism: Emericella nidulans

ncbitaxon 224911 1197
type: UnificationXref
id: 224911
db: ncbitaxon

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 36

uniprot Q6PE34 845
type: UnificationXref
id: Q6PE34
db: uniprot

Tubulin beta-2 chain
type: ProteinReference
xref: uniprot P10874 796
xref: PTHR11588:SF291
organism: Emericella nidulans

Microtubule
type: ProteinReference
xref: P00780
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Microtubule
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Tubulin beta chain
member entity reference: Tubulin beta-1 chain
member entity reference: Tubulin beta-3 chain
member entity reference: Tubulin beta-2 chain
member entity reference: Tubulin beta-2A chain
member entity reference: Probable tubulin beta chain CG32396
member entity reference: Tubulin beta-5 chain
member entity reference: Tubulin beta-8 chain
member entity reference: Tubulin beta-4 chain
member entity reference: Tubulin beta-4B chain
member entity reference: Tubulin beta-6 chain
member entity reference: Tubulin beta-4A chain
member entity reference: Tubulin beta 3 class III
member entity reference: Tubulin beta-7 chain
member entity reference: Tubulin beta-2B chain
member entity reference: Uncharacterized protein

Dynein heavy chain 3, axonemal
type: ProteinReference
xref: PTHR10676:SF242
xref: uniprot Q8TD57 567
organism: Homo sapiens

Calpain 2
type: ProteinReference
xref: uniprot A0A2I3TQ02 113
xref: PTHR10183:SF268
organism: Pan troglodytes

uniprot E2RFR5 463
type: UnificationXref
id: E2RFR5
db: uniprot

PIG3
type: DnaRegion
entity reference: Tumor protein p53 inducible protein 3
cellular location: nucleus
comment: SPECIES_TYPE=GENE

Glutamate receptor ionotropic, kainate 3
type: ProteinReference
xref: PTHR18966:SF174
xref: uniprot B1AS29 625
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR10676:SF314
xref: uniprot F6X0U8 487
organism: Ornithorhynchus anatinus

Glutamate receptor ionotropic, NMDA 2D
type: ProteinReference
evidence: Evidence 49
evidence: Evidence 54
evidence: Evidence 55
xref: uniprot Q62645 75
xref: PTHR18966:SF385
organism: Rattus norvegicus

uniprot P40946 1455
type: UnificationXref
id: P40946
db: uniprot

ADP-ribosylation factor 1
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot Q803D1 1518
organism: Danio rerio

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot E3K4I1 255
organism: Puccinia graminis

uniprot P29517 801
type: UnificationXref
id: P29517
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot Q4Q4C4 831
organism: Leishmania major

uniprot A0A2I3RT65 111
type: UnificationXref
id: A0A2I3RT65
db: uniprot

Intraflagellar transport protein 57 homolog
type: ProteinReference
xref: uniprot A0A452DIR3 1083
xref: PTHR16011:SF0
organism: Bos taurus

uniprot P04350 786
type: UnificationXref
id: P04350
db: uniprot

uniprot O02795 595
type: UnificationXref
id: O02795
db: uniprot

uniprot P62737 341
type: UnificationXref
id: P62737
db: uniprot

uniprot A7S027 725
type: UnificationXref
id: A7S027
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZLR4 129
xref: PTHR10183:SF284
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot C3Z4K3 248
xref: PTHR11937:SF468
organism: Branchiostoma floridae

N-methyl-D-aspartate receptor type 1 subunit
type: ProteinReference
evidence: Evidence 22
xref: uniprot Q6R6I2 76
xref: PTHR18966:SF377
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot E1C2Q1 628
xref: PTHR18966:SF171
organism: Gallus gallus

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot A2DC16 722
organism: Trichomonas vaginalis

uniprot F7CIV4 286
type: UnificationXref
id: F7CIV4
db: uniprot

uniprot Q9VAM8 1206
type: UnificationXref
id: Q9VAM8
db: uniprot

uniprot E2RHL4 1398
type: UnificationXref
id: E2RHL4
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q9P8C0 994
organism: Phaeosphaeria nodorum

uniprot A8WNX0 908
type: UnificationXref
id: A8WNX0
db: uniprot

uniprot A7MB62 201
type: UnificationXref
id: A7MB62
db: uniprot

Dynein light chain 1, cytoplasmic
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot Q9UR05 584
organism: Schizosaccharomyces pombe

Tubulin beta chain
type: ProteinReference
xref: uniprot F7HTD6 772
xref: PTHR11588:SF330
organism: Macaca mulatta

uniprot F1MM66 1074
type: UnificationXref
id: F1MM66
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: CBP

Predicted protein
type: ProteinReference
xref: uniprot A9V489 224
xref: PTHR11937:SF387
organism: Monosiga brevicollis

beta-Tubulin
type: Complex
component stoichiometry: beta Tubulin s168 a225 STOICHIOMETRY ID COMPLEX
component: beta-Tubulin
cellular location: synapse

Uncharacterized protein
type: ProteinReference
evidence: Evidence 25
evidence: Evidence 22
xref: PTHR18966:SF382
xref: uniprot F1MCL3 34
organism: Bos taurus

Actin, alpha cardiac muscle 2
type: ProteinReference
xref: PTHR11937:SF416
xref: uniprot P20399 322
organism: Xenopus tropicalis

uniprot Q03206 1265
type: UnificationXref
id: Q03206
db: uniprot

GAPDH
type: Protein
entity reference: GAPDH
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Paired amphipathic helix protein Sin3a
type: ProteinReference
xref: PTHR12346:SF2
xref: uniprot Q60520 105
organism: Mus musculus

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot P60710 335
organism: Mus musculus

Jun proto-oncogene
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot F6RYL1 1127
organism: Xenopus tropicalis

uniprot F4NRM0 1411
type: UnificationXref
id: F4NRM0
db: uniprot

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot P60711 336
xref: PTHR11937:SF192
organism: Rattus norvegicus

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot P60712 337
organism: Bos taurus

Tubulin beta-3 chain
type: ProteinReference
xref: PTHR11588:SF43
xref: uniprot Q2T9S0 823
organism: Bos taurus

Dynein light chain
type: ProteinReference
xref: uniprot W4YRY2 592
xref: PTHR11886:SF91
organism: Strongylocentrotus purpuratus

uniprot F7B0P2 764
type: UnificationXref
id: F7B0P2
db: uniprot

uniprot P68371 810
type: UnificationXref
id: P68371
db: uniprot

Glutamate receptor, ionotropic, N-methyl D-aspartate 1b
type: ProteinReference
evidence: Evidence 22
xref: uniprot Q6ZM67 77
xref: PTHR18966:SF497
organism: Danio rerio

uniprot O34425 925
type: UnificationXref
id: O34425
db: uniprot

uniprot Q8NCM8 565
type: UnificationXref
id: Q8NCM8
db: uniprot

Cytoplasmic dynein 1 intermediate chain 2
type: ProteinReference
xref: PTHR12442:SF37
xref: uniprot Q13409 531
organism: Homo sapiens

Tubulin beta chain
type: ProteinReference
xref: uniprot H2RB52 777
xref: PTHR11588:SF88
organism: Pan troglodytes

Calpain-3
type: ProteinReference
xref: PTHR10183:SF329
xref: uniprot A0A1D5PLJ8 108
organism: Gallus gallus

Dynein heavy chain at 16F
type: ProteinReference
xref: PTHR10676:SF339
xref: uniprot Q9VWZ3 587
organism: Drosophila melanogaster

Calpain-12
type: ProteinReference
xref: uniprot Q9ER56 172
xref: PTHR10183:SF280
organism: Mus musculus

uniprot C3ZMR2 251
type: UnificationXref
id: C3ZMR2
db: uniprot

AP-2 complex subunit alpha
type: ProteinReference
xref: PTHR22780:SF4
xref: uniprot P38065 890
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r37 1709
type: Stoichiometry
physical entity: CBP
stoichiometric coefficient: 1.0

uniprot F1LP57 613
type: UnificationXref
id: F1LP57
db: uniprot

uniprot A0A2I3SDN3 112
type: UnificationXref
id: A0A2I3SDN3
db: uniprot

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF91
xref: uniprot G3MX54 500
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r37 1710
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 1.0

uniprot C3YKS6 246
type: UnificationXref
id: C3YKS6
db: uniprot

PARTICIPANT STOICHIOMETRY r37 1711
type: Stoichiometry
physical entity: Complex (CBP/PolyQ Htt)
stoichiometric coefficient: 1.0

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot P60709 334
xref: PTHR11937:SF192
organism: Homo sapiens

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot P60706 333
organism: Gallus gallus

Htt s73 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Htt
stoichiometric coefficient: 1.0

Complex (Microtubule/Dynein complex/ Dynactin/HAP1/ Htt)
type: Complex
component stoichiometry: Dynactin s69 sa26 STOICHIOMETRY ID COMPLEX
component stoichiometry: Dynein complex s68 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: Htt s72 sa28 STOICHIOMETRY ID COMPLEX
component stoichiometry: HAP1 s71 sa27 STOICHIOMETRY ID COMPLEX
component stoichiometry: Microtubule s67 sa24 STOICHIOMETRY ID COMPLEX
component: HAP1
component: Dynactin
component: Htt
component: Microtubule
component: Dynein complex
feature: COMPLEX BINDING FEATURE s121 a155 1560
feature: COMPLEX BINDING FEATURE s121 a155 1566
feature: COMPLEX BINDING FEATURE s121 a155 1564
feature: COMPLEX BINDING FEATURE s121 a155 1558
feature: COMPLEX BINDING FEATURE s121 a155 1562
cellular location: clathrin coat of endocytic vesicle

Uncharacterized protein
type: ProteinReference
xref: PTHR12442:SF7
xref: uniprot F7H0G5 498
organism: Macaca mulatta

Truncated Htt s76 a102 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Truncated Htt
stoichiometric coefficient: 8.0

uniprot P17721 949
type: UnificationXref
id: P17721
db: uniprot

uniprot Q27971 160
type: UnificationXref
id: Q27971
db: uniprot

ncbitaxon 45351 203
type: UnificationXref
id: 45351
db: ncbitaxon

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 198

uniprot Q90694 1296
type: UnificationXref
id: Q90694
db: uniprot

uniprot P68372 811
type: UnificationXref
id: P68372
db: uniprot

STATE_TRANSITION_LEFT__Arp2_3_complex-RIGHT__Arp2_3_complex-_r66
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 1714
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 1715
left: Arp2/3 complex
interaction type: STATE_TRANSITION
right: Arp2/3 complex

Rho-related GTP-binding protein RhoG
type: ProteinReference
xref: PTHR24072:SF158
xref: uniprot P84096 1262
organism: Mus musculus

Rho-related GTP-binding protein RhoG
type: ProteinReference
xref: PTHR24072:SF158
xref: uniprot P84095 1261
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EPS9 430
xref: PTHR10407:SF14
organism: Macaca mulatta

uniprot P04797 934
type: UnificationXref
id: P04797
db: uniprot

GAPDH
type: ProteinReference
xref: P00810
standard name: Glyceraldehyde-3-phosphate dehydrogenase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.GAPDH
comment: ENTITY_REFERENCE_NOTES= Long Name: Glyceraldehyde-3-phosphate dehydrogenase Synonym: G3PD Accession: P00810
member entity reference: Glyceraldehyde-3-phosphate dehydrogenase 1
member entity reference: Glyceraldehyde-3-phosphate dehydrogenase
member entity reference: Glyceraldehyde-3-phosphate dehydrogenase GAPB, chloroplastic
member entity reference: Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
member entity reference: Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic
member entity reference: Glyceraldehyde-3-phosphate dehydrogenase 3
member entity reference: Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic
member entity reference: Glyceraldehyde-3-phosphate dehydrogenase 4
member entity reference: Uncharacterized protein
member entity reference: Glyceraldehyde-3-phosphate dehydrogenase A
member entity reference: Glyceraldehyde-3-phosphate dehydrogenase 2
member entity reference: Glyceraldehyde-3-phosphate dehydrogenase GAPA2, chloroplastic
member entity reference: Glyceraldehyde-3-phosphate dehydrogenase 3, cytosolic
member entity reference: Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic
member entity reference: Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic
member entity reference: Glyceraldehyde-3-phosphate dehydrogenase (Fragment)

Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic
type: ProteinReference
xref: uniprot Q0J8A4 964
organism: Oryza sativa

Hip-12
type: ProteinReference
xref: P00763
standard name: Huntingtin interacting protein 12
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Huntington disease.PROTEIN.GENERIC.Hip-12
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Intraflagellar transport protein 57 homolog
member entity reference: Uncharacterized protein
member entity reference: HIP1R isoform 1
member entity reference: IFT57 isoform 1
member entity reference: Huntingtin-interacting protein 1-related protein
member entity reference: Intraflagellar transport 57
member entity reference: Huntingtin-interacting protein 1-related

Huntingtin-interacting protein 1
type: ProteinReference
xref: PTHR10407:SF14
xref: uniprot O00291 432
organism: Homo sapiens

Dynein heavy chain, cytoplasmic
type: ProteinReference
xref: PTHR10676:SF314
xref: uniprot P45444 524
organism: Emericella nidulans

PTHR10183:SF374
type: RelationshipXref
id: PTHR10183:SF374
db: PANTHER Family
relationship type: By Homology

uniprot Q20758 1486
type: UnificationXref
id: Q20758
db: uniprot

Dynein heavy chain, cytoplasmic
type: ProteinReference
xref: uniprot P45443 523
xref: PTHR10676:SF314
organism: Neurospora crassa

PTHR10183:SF379
type: RelationshipXref
id: PTHR10183:SF379
db: PANTHER Family
relationship type: By Homology

uniprot Q7Q1U8 979
type: UnificationXref
id: Q7Q1U8
db: uniprot

Actin alpha 2, smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot Q6DHS1 387
organism: Danio rerio

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot P01101 428
organism: Mus musculus

Cell division cycle 42
type: ProteinReference
xref: uniprot Q52WY2 1279
organism: Danio rerio

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot P01100 427
organism: Homo sapiens

Arfaptin 2 s116 sa57 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Arfaptin-2
stoichiometric coefficient: 1.0

Dynein cytoplasmic 1 light intermediate chain 2
type: ProteinReference
xref: PTHR12688:SF1
xref: uniprot A0A2I3RZ29 439
organism: Pan troglodytes

ncbitaxon 243274 950
type: UnificationXref
id: 243274
db: ncbitaxon

STATE_TRANSITION_LEFT__Caspase_3-RIGHT__Caspase_3-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 1693
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 1694
left: Caspase 3
interaction type: STATE_TRANSITION
right: Caspase 3

uniprot Q9FKS5 1202
type: UnificationXref
id: Q9FKS5
db: uniprot

ADP ribosylation factor like GTPase 4C
type: ProteinReference
xref: uniprot F1PCE1 1407
xref: PTHR11711:SF119
organism: Canis lupus familiaris

uniprot E2RMT4 1032
type: UnificationXref
id: E2RMT4
db: uniprot

uniprot A8HP84 906
type: UnificationXref
id: A8HP84
db: uniprot

Dynein light chain 4, axonemal
type: ProteinReference
xref: PTHR11886:SF73
xref: uniprot Q9DCM4 578
organism: Mus musculus

uniprot A9SJR1 735
type: UnificationXref
id: A9SJR1
db: uniprot

uniprot W4XLU7 591
type: UnificationXref
id: W4XLU7
db: uniprot

ADP-ribosylation factor 1
type: ProteinReference
xref: uniprot P84079 1476
xref: PTHR11711:SF357
organism: Rattus norvegicus

ADP-ribosylation factor 1
type: ProteinReference
xref: uniprot P84078 1475
xref: PTHR11711:SF357
organism: Mus musculus

Calpain-3
type: ProteinReference
xref: PTHR10183:SF329
xref: uniprot P16259 152
organism: Rattus norvegicus

ADP-ribosylation factor 1
type: ProteinReference
xref: uniprot P84077 1474
xref: PTHR11711:SF357
organism: Homo sapiens

uniprot F1PUS6 477
type: UnificationXref
id: F1PUS6
db: uniprot

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 229

PARTICIPANT STOICHIOMETRY r53 1745
type: Stoichiometry
physical entity: Complex (PolyQ Htt/GAPDH)
stoichiometric coefficient: 1.0

Duo
type: Protein
entity reference: Duo
feature: COMPLEX PARTICIPANT BINDING FEATURE s111 sa54 1613
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

uniprot Q6NVA9 390
type: UnificationXref
id: Q6NVA9
db: uniprot

uniprot Q05062 1266
type: UnificationXref
id: Q05062
db: uniprot

PARTICIPANT STOICHIOMETRY r53 1744
type: Stoichiometry
physical entity: Complex (PolyQ Htt/GAPDH)
stoichiometric coefficient: 1.0

PTHR24072:SF325
type: RelationshipXref
id: PTHR24072:SF325
db: PANTHER Family
relationship type: By Homology

uniprot F7AGW3 638
type: UnificationXref
id: F7AGW3
db: uniprot

uniprot Q8R1Q8 566
type: UnificationXref
id: Q8R1Q8
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF2
xref: uniprot Q7PWN2 1057
organism: Anopheles gambiae

PTHR10183:SF396
type: RelationshipXref
id: PTHR10183:SF396
db: PANTHER Family
relationship type: By Homology

uniprot Q4Q6Z5 969
type: UnificationXref
id: Q4Q6Z5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12688:SF1
xref: uniprot F6PWI8 479
organism: Monodelphis domestica

uniprot F6S4U6 1414
type: UnificationXref
id: F6S4U6
db: uniprot

Sin3A s44 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Sin3A
stoichiometric coefficient: 1.0

Cytoplasmic dynein 2 heavy chain 1
type: ProteinReference
xref: PTHR10676:SF352
xref: uniprot Q19542 534
organism: Caenorhabditis elegans

ADP-ribosylation factor 5
type: ProteinReference
xref: uniprot P84084 1481
xref: PTHR11711:SF323
organism: Mus musculus

Dynein light chain
type: ProteinReference
xref: PTHR11886:SF35
xref: uniprot H2QDI5 503
organism: Pan troglodytes

ADP-ribosylation factor 5
type: ProteinReference
xref: uniprot P84083 1480
xref: PTHR11711:SF323
organism: Rattus norvegicus

ADP-ribosylation factor 5
type: ProteinReference
xref: PTHR11711:SF323
xref: uniprot P84085 1482
organism: Homo sapiens

uniprot P70677 1151
type: UnificationXref
id: P70677
db: uniprot

ADP-ribosylation factor 1
type: ProteinReference
xref: PTHR11711:SF357
xref: uniprot P84080 1477
organism: Bos taurus

Histone acetyltransferase HAC1
type: ProteinReference
xref: uniprot Q9C5X9 1015
xref: PTHR13808:SF1
organism: Arabidopsis thaliana

ADP-ribosylation factor 2
type: ProteinReference
xref: uniprot P84082 1479
xref: PTHR11711:SF30
organism: Rattus norvegicus

uniprot Q6DEU5 550
type: UnificationXref
id: Q6DEU5
db: uniprot

Rac family small GTPase 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q5U1Y2 1281
organism: Rattus norvegicus

ADP-ribosylation factor 2
type: ProteinReference
xref: uniprot P84081 1478
xref: PTHR11711:SF30
organism: Bos taurus

PTHR23065:SF16
type: RelationshipXref
id: PTHR23065:SF16
db: PANTHER Family
relationship type: By Homology

Dynein cytoplasmic 2 heavy chain 1
type: ProteinReference
xref: uniprot E2RDH6 461
xref: PTHR10676:SF352
organism: Canis lupus familiaris

PTHR10183:SF385
type: RelationshipXref
id: PTHR10183:SF385
db: PANTHER Family
relationship type: By Homology

GO GO:0005634 4
type: UnificationXref
id: GO:0005634
db: GO

PTHR11462:SF8
type: RelationshipXref
id: PTHR11462:SF8
db: PANTHER Family
relationship type: By Homology

uniprot C3ZIB9 1216
type: UnificationXref
id: C3ZIB9
db: uniprot

Glyceraldehyde-3-phosphate dehydrogenase GAPCP2, chloroplastic
type: ProteinReference
xref: uniprot Q5E924 972
organism: Arabidopsis thaliana

ncbitaxon 189518 982
type: UnificationXref
id: 189518
db: ncbitaxon

PTHR10183:SF381
type: RelationshipXref
id: PTHR10183:SF381
db: PANTHER Family
relationship type: By Homology

uniprot Q52366 1349
type: UnificationXref
id: Q52366
db: uniprot

ADP-ribosylation factor 3
type: ProteinReference
xref: PTHR11711:SF322
xref: uniprot P40994 1456
organism: Saccharomyces cerevisiae

uniprot Q55EU6 374
type: UnificationXref
id: Q55EU6
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 317

Ashbya gossypii
type: BioSource
xref: ncbitaxon 284811 397

uniprot A7EH60 724
type: UnificationXref
id: A7EH60
db: uniprot

uniprot P63000 1259
type: UnificationXref
id: P63000
db: uniprot

Duo
type: Protein
entity reference: Duo
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9615 11
type: UnificationXref
id: 9615
db: ncbitaxon

Proline dehydrogenase 1, mitochondrial
type: DnaReference
organism: Mus musculus

uniprot F0ZN94 1222
type: UnificationXref
id: F0ZN94
db: uniprot

Endophilin-A3
type: ProteinReference
xref: uniprot Q99963 1181
xref: PTHR14167:SF45
organism: Homo sapiens

PTHR10183:SF329
type: RelationshipXref
id: PTHR10183:SF329
db: PANTHER Family
relationship type: By Homology

Glutamate ionotropic receptor kainate type subunit 5
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot A0A2I3S1J9 620
organism: Pan troglodytes

Htt s16 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Htt
stoichiometric coefficient: 1.0

uniprot Q03391 66
type: UnificationXref
id: Q03391
db: uniprot

uniprot E9GF36 917
type: UnificationXref
id: E9GF36
db: uniprot

Dynein axonemal heavy chain 7
type: ProteinReference
xref: PTHR10676:SF310
xref: uniprot F1PUS6 477
organism: Canis lupus familiaris

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q9Z518 999
organism: Streptomyces coelicolor

uniprot B2RZ70 1391
type: UnificationXref
id: B2RZ70
db: uniprot

Probable glutamate receptor
type: ProteinReference
xref: PTHR18966:SF417
xref: uniprot A0A452J7P8 623
organism: Gallus gallus

Tubulin beta-2A chain
type: ProteinReference
xref: PTHR11588:SF100
xref: uniprot P85108 814
organism: Rattus norvegicus

Actin-related protein 2-A
type: ProteinReference
xref: uniprot Q7SXW6 400
xref: PTHR11937:SF149
organism: Danio rerio

Protein CBR-MIG-2
type: ProteinReference
xref: uniprot A8XQS8 1211
organism: Caenorhabditis briggsae

PTHR10183:SF322
type: RelationshipXref
id: PTHR10183:SF322
db: PANTHER Family
relationship type: By Homology

PolyQ HTT
type: RnaRegion
cellular location: synapse
comment: SPECIES_TYPE=RNA

uniprot P68133 355
type: UnificationXref
id: P68133
db: uniprot

Dynein light chain
type: ProteinReference
xref: uniprot F7G757 496
xref: PTHR11886:SF35
organism: Monodelphis domestica

uniprot P04637 700
type: UnificationXref
id: P04637
db: uniprot

Rop-family small GTPase
type: ProteinReference
xref: uniprot A9TLC7 1213
organism: Physcomitrella patens

SH3 domain containing GRB2 like 3, endophilin A3
type: ProteinReference
xref: uniprot F1MX23 1179
xref: PTHR14167:SF45
organism: Bos taurus

uniprot C4M5Z7 1219
type: UnificationXref
id: C4M5Z7
db: uniprot

uniprot F6T8S6 40
type: UnificationXref
id: F6T8S6
db: uniprot

uniprot F6XP81 1165
type: UnificationXref
id: F6XP81
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HFY2 1147
xref: PTHR10454:SF198
organism: Macaca mulatta

Quinone oxidoreductase 1
type: DnaReference
xref: PTHR48106:SF13
organism: Escherichia coli

uniprot P61751 1470
type: UnificationXref
id: P61751
db: uniprot

uniprot Q9C5X9 1015
type: UnificationXref
id: Q9C5X9
db: uniprot

uniprot A2VE57 624
type: UnificationXref
id: A2VE57
db: uniprot

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 319

uniprot E2R6T4 1126
type: UnificationXref
id: E2R6T4
db: uniprot

ADP-ribosylation factor 1-like 2
type: ProteinReference
xref: uniprot Q10943 1485
xref: PTHR11711:SF381
organism: Caenorhabditis elegans

uniprot H2QG30 923
type: UnificationXref
id: H2QG30
db: uniprot

uniprot A9TLC7 1213
type: UnificationXref
id: A9TLC7
db: uniprot

Alpha-cardiac actin
type: ProteinReference
xref: uniprot F7F210 290
xref: PTHR11937:SF176
organism: Macaca mulatta

Actin-related protein 2/3 complex subunit 5-like protein
type: ProteinReference
xref: uniprot Q5E963 1055
xref: PTHR12644:SF2
organism: Bos taurus

uniprot B3RQ31 736
type: UnificationXref
id: B3RQ31
db: uniprot

uniprot P20399 322
type: UnificationXref
id: P20399
db: uniprot

uniprot P20226 1336
type: UnificationXref
id: P20226
db: uniprot

uniprot Q76FS3 852
type: UnificationXref
id: Q76FS3
db: uniprot

uniprot Q9LK29 1205
type: UnificationXref
id: Q9LK29
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF474
xref: uniprot Q67G20 386
organism: Oryza sativa

uniprot D3ZGY4 914
type: UnificationXref
id: D3ZGY4
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Htt-RIGHT__Protein_fragment-_Truncated_Htt-_r22
controller: Caspase 6

PTHR11937:SF389
type: RelationshipXref
id: PTHR11937:SF389
db: PANTHER Family
relationship type: By Homology

uniprot E2R8R0 915
type: UnificationXref
id: E2R8R0
db: uniprot

uniprot Q9VF87 715
type: UnificationXref
id: Q9VF87
db: uniprot

uniprot P34545 1010
type: UnificationXref
id: P34545
db: uniprot

uniprot Q01812 649
type: UnificationXref
id: Q01812
db: uniprot

PTHR11937:SF387
type: RelationshipXref
id: PTHR11937:SF387
db: PANTHER Family
relationship type: By Homology

uniprot C4M5T0 1218
type: UnificationXref
id: C4M5T0
db: uniprot

uniprot Q13885 818
type: UnificationXref
id: Q13885
db: uniprot

ncbitaxon 272561 942
type: UnificationXref
id: 272561
db: ncbitaxon

Tubulin beta chain
type: ProteinReference
xref: uniprot P05220 788
xref: PTHR11588:SF9
organism: Neurospora crassa

Paired amphipathic helix protein Sin3b
type: ProteinReference
xref: PTHR12346:SF1
xref: uniprot O75182 102
organism: Homo sapiens

uniprot F6VQZ3 1021
type: UnificationXref
id: F6VQZ3
db: uniprot

uniprot P40792 1252
type: UnificationXref
id: P40792
db: uniprot

PTHR11937:SF397
type: RelationshipXref
id: PTHR11937:SF397
db: PANTHER Family
relationship type: By Homology

ncbitaxon 6238 29
type: UnificationXref
id: 6238
db: ncbitaxon

ncbitaxon 7668 319
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot O08788 1315
type: UnificationXref
id: O08788
db: uniprot

uniprot Q05144 1267
type: UnificationXref
id: Q05144
db: uniprot

ADP-ribosylation factor 1
type: ProteinReference
xref: PTHR11711:SF336
xref: uniprot Q7F270 1511
organism: Oryza sativa

Glyceraldehyde-3-phosphate dehydrogenase 3, cytosolic
type: ProteinReference
xref: uniprot Q6K5G8 976
organism: Oryza sativa

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q05144 1267
organism: Mus musculus

MAPKK7
type: Protein
entity reference: MAPKK7
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Thalassiosira pseudonana
type: BioSource
xref: ncbitaxon 35128 741

PTHR11711:SF41
type: RelationshipXref
id: PTHR11711:SF41
db: PANTHER Family
relationship type: By Homology

Zgc:55262
type: ProteinReference
xref: uniprot F1QI24 126
xref: PTHR10183:SF284
organism: Danio rerio

uniprot P62330 1471
type: UnificationXref
id: P62330
db: uniprot

uniprot H2QX95 660
type: UnificationXref
id: H2QX95
db: uniprot

Actin-related protein 3
type: ProteinReference
xref: PTHR11937:SF175
xref: uniprot Q9N4I0 411
organism: Caenorhabditis elegans

Optineurin
type: ProteinReference
xref: uniprot Q8K3K8 1142
organism: Mus musculus

PTHR22826:SF49
type: RelationshipXref
id: PTHR22826:SF49
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r38 1708
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 8.0

uniprot F6ZK75 489
type: UnificationXref
id: F6ZK75
db: uniprot

uniprot Q9SDK0 583
type: UnificationXref
id: Q9SDK0
db: uniprot

uniprot C7G3L6 627
type: UnificationXref
id: C7G3L6
db: uniprot

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 203

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r28
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 1723
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 1724
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

Proline dehydrogenase 1, mitochondrial
type: DnaReference
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r38 1707
type: Stoichiometry
physical entity: PolyQ Htt
stoichiometric coefficient: 1.0

MAPKK7
type: Protein
entity reference: MAPKK7
feature: ACTIVE 84
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

PTHR11711:SF30
type: RelationshipXref
id: PTHR11711:SF30
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR10183:SF402
xref: uniprot F7EDU0 130
organism: Macaca mulatta

PTHR44054:SF1
type: RelationshipXref
id: PTHR44054:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q6B856 838
type: UnificationXref
id: Q6B856
db: uniprot

PTHR44054:SF2
type: RelationshipXref
id: PTHR44054:SF2
db: PANTHER Family
relationship type: By Homology

PTHR24055:SF172
type: RelationshipXref
id: PTHR24055:SF172
db: PANTHER Family
relationship type: By Homology

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q28259 965
xref: PTHR10836:SF111
organism: Canis lupus familiaris

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot P05219 787
organism: Schizosaccharomyces pombe

uniprot Q14203 1319
type: UnificationXref
id: Q14203
db: uniprot

uniprot H3DZP2 778
type: UnificationXref
id: H3DZP2
db: uniprot

uniprot F6SCP4 275
type: UnificationXref
id: F6SCP4
db: uniprot

CREB-binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot P45481 1011
organism: Mus musculus

uniprot P31016 1078
type: UnificationXref
id: P31016
db: uniprot

uniprot P16259 152
type: UnificationXref
id: P16259
db: uniprot

Dynein light chain
type: ProteinReference
xref: uniprot G2HG77 499
xref: PTHR11886:SF73
organism: Pan troglodytes

TRANSPORT_LEFT__Cytochrome_c-RIGHT__Cytochrome_c-_r29
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 1722
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 1721
left: Cytochrome c
interaction type: TRANSPORT
right: Cytochrome c

uniprot F7AZV1 492
type: UnificationXref
id: F7AZV1
db: uniprot

Histone acetyltransferase p300
type: ProteinReference
xref: PTHR13808:SF29
xref: uniprot Q09472 1012
organism: Homo sapiens

uniprot Q5M8T9 382
type: UnificationXref
id: Q5M8T9
db: uniprot

Hip-12
type: Protein
entity reference: Hip-12
feature: COMPLEX PARTICIPANT BINDING FEATURE s82 sa36 1621
cellular location: clathrin coat of endocytic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot L7N3Q3 783
type: UnificationXref
id: L7N3Q3
db: uniprot

Putative actin-5
type: ProteinReference
xref: uniprot Q8RYC2 408
xref: PTHR11937:SF411
organism: Arabidopsis thaliana

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot G2HG81 1040
xref: PTHR12644:SF1
organism: Pan troglodytes

uniprot W4YA56 1363
type: UnificationXref
id: W4YA56
db: uniprot

PANTHER Pathway P00029 1
type: UnificationXref
id: P00029
db: PANTHER Pathway

Probable quinone oxidoreductase
type: DnaReference
xref: PTHR48106:SF13
organism: Saccharomyces cerevisiae

Cytoplasmic FMR1-interacting protein homolog
type: ProteinReference
xref: uniprot O44518 697
organism: Caenorhabditis elegans

ADP ribosylation factor interacting protein 2
type: ProteinReference
xref: PTHR12141:SF3
xref: uniprot E2QV23 1096
organism: Canis lupus familiaris

uniprot Q9LPW0 993
type: UnificationXref
id: Q9LPW0
db: uniprot

uniprot Q8R4C0 166
type: UnificationXref
id: Q8R4C0
db: uniprot

Huntingtin-interacting protein 1-related protein
type: ProteinReference
xref: uniprot O75146 1091
organism: Homo sapiens

uniprot F1NE09 680
type: UnificationXref
id: F1NE09
db: uniprot

PTHR11937:SF359
type: RelationshipXref
id: PTHR11937:SF359
db: PANTHER Family
relationship type: By Homology

Glyceraldehyde-3-phosphate dehydrogenase GAPB, chloroplastic
type: ProteinReference
xref: uniprot P25857 953
organism: Arabidopsis thaliana

Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic
type: ProteinReference
xref: uniprot P25858 954
organism: Arabidopsis thaliana

Dynein light chain
type: ProteinReference
xref: uniprot H3EKK6 510
xref: PTHR11886:SF35
organism: Pristionchus pacificus

uniprot F6WW23 486
type: UnificationXref
id: F6WW23
db: uniprot

uniprot O89090 1123
type: UnificationXref
id: O89090
db: uniprot

uniprot H2QCA7 1325
type: UnificationXref
id: H2QCA7
db: uniprot

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 22
xref: PTHR18966:SF377
xref: uniprot Q5R1P0 73
organism: Canis lupus familiaris

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 25
evidence: Evidence 22
xref: uniprot Q5R1P3 74
xref: PTHR18966:SF382
organism: Canis lupus familiaris

uniprot F7DMS9 1425
type: UnificationXref
id: F7DMS9
db: uniprot

Calpain-2 catalytic subunit
type: ProteinReference
xref: uniprot P17655 153
xref: PTHR10183:SF268
organism: Homo sapiens

uniprot P60709 334
type: UnificationXref
id: P60709
db: uniprot

PTHR22780:SF4
type: RelationshipXref
id: PTHR22780:SF4
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot F1A175 265
organism: Dictyostelium purpureum

Kalirin
type: ProteinReference
xref: PTHR22826:SF49
xref: uniprot A2CG49 1532
organism: Mus musculus

Jun proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: uniprot E2R6T4 1126
xref: PTHR11462:SF8
organism: Canis lupus familiaris

NMDA class glutamate Receptor
type: ProteinReference
evidence: Evidence 49
xref: uniprot G5EGQ9 47
xref: PTHR18966:SF377
organism: Caenorhabditis elegans

uniprot P10653 795
type: UnificationXref
id: P10653
db: uniprot

PTHR11937:SF362
type: RelationshipXref
id: PTHR11937:SF362
db: PANTHER Family
relationship type: By Homology

Tubulin beta-6 chain
type: ProteinReference
xref: PTHR11588:SF88
xref: uniprot Q9BUF5 860
organism: Homo sapiens

uniprot Q19020 533
type: UnificationXref
id: Q19020
db: uniprot

uniprot F7HPP3 643
type: UnificationXref
id: F7HPP3
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot F6WYK8 761
xref: PTHR11588:SF247
organism: Monodelphis domestica

Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic
type: ProteinReference
xref: uniprot P25856 952
organism: Arabidopsis thaliana

uniprot P0A9B2 939
type: UnificationXref
id: P0A9B2
db: uniprot

uniprot P07143 1194
type: UnificationXref
id: P07143
db: uniprot

TRANSCRIPTION_LEFT__Bax-RIGHT__Bax-_re66
type: TemplateReaction
product: Bax
xref: TRANSCRIPTION
participant: Bax
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot P10874 796
type: UnificationXref
id: P10874
db: uniprot

uniprot F7BRR0 1136
type: UnificationXref
id: F7BRR0
db: uniprot

uniprot Q5BJ34 1498
type: UnificationXref
id: Q5BJ34
db: uniprot

Rab8
type: Protein
entity reference: Rab8
feature: COMPLEX PARTICIPANT BINDING FEATURE s89 sa42 1633
cellular location: synapse
comment: SPECIES_TYPE=PROTEIN

Transcription initiation factor TFIID subunit 4
type: ProteinReference
xref: uniprot O00268 180
xref: PTHR15138:SF18
organism: Homo sapiens

Actin
type: ProteinReference
xref: uniprot Q75HX0 398
xref: PTHR11937:SF248
organism: Oryza sativa

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot F7BZM9 1039
xref: PTHR10709:SF11
organism: Monodelphis domestica

uniprot F7DCY3 768
type: UnificationXref
id: F7DCY3
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P67939 702
xref: PTHR11447:SF6
organism: Bos taurus

uniprot E1B7A3 457
type: UnificationXref
id: E1B7A3
db: uniprot

uniprot E2QYK5 422
type: UnificationXref
id: E2QYK5
db: uniprot

Calpain-9
type: ProteinReference
xref: uniprot O14815 141
xref: PTHR10183:SF385
organism: Homo sapiens

Dynein light chain
type: ProteinReference
xref: uniprot E1B7A3 457
xref: PTHR11886:SF62
organism: Bos taurus

uniprot P19073 1245
type: UnificationXref
id: P19073
db: uniprot