HIF 1alpha s2 sa2 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

HIF-1beta
type: Protein
entity reference: HIF-1beta
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 3

uniprot P52230 141
type: UnificationXref
id: P52230
db: uniprot

uniprot F7E905 12
type: UnificationXref
id: F7E905
db: uniprot

PTHR24351:SF200
type: RelationshipXref
id: PTHR24351:SF200
db: PANTHER Family
relationship type: By Homology

ncbitaxon 559292 38
type: UnificationXref
id: 559292
db: ncbitaxon

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Increased Angiogenesis
controller: HRE gene/high transcription

PTHR24356:SF176
type: RelationshipXref
id: PTHR24356:SF176
db: PANTHER Family
relationship type: By Homology

Thioredoxin
type: ProteinReference
xref: PTHR10438:SF18
xref: uniprot O97680 131
organism: Bos taurus

uniprot Q9JLN9 45
type: UnificationXref
id: Q9JLN9
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6RCU6 69
xref: PTHR24356:SF171
organism: Macaca mulatta

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: PTHR11139:SF9
xref: uniprot E2R2L2 28
organism: Canis lupus familiaris

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: uniprot P42346 41
xref: PTHR11139:SF9
organism: Rattus norvegicus

uniprot Q8T9S7 120
type: UnificationXref
id: Q8T9S7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12907:SF4
xref: uniprot F7BR59 97
organism: Macaca mulatta

uniprot P27540 92
type: UnificationXref
id: P27540
db: uniprot

Serine/threonine-protein kinase TOR1
type: ProteinReference
xref: uniprot P35169 39
organism: Saccharomyces cerevisiae

ncbitaxon 100226 142
type: UnificationXref
id: 100226
db: ncbitaxon

Mus musculus
type: BioSource
xref: ncbitaxon 10090 17

uniprot F6RHG3 126
type: UnificationXref
id: F6RHG3
db: uniprot

PARTICIPANT STOICHIOMETRY re19 197
type: Stoichiometry
physical entity: Prolyl Hydroxylase
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 196
type: Stoichiometry
physical entity: Prolyl Hydroxylase
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF333
xref: uniprot Q7QK56 84
organism: Anopheles gambiae

Thioredoxin
type: ProteinReference
xref: uniprot B7PXT0 124
organism: Ixodes scapularis

HIF-1alpha
type: Protein
entity reference: HIF-1alpha
feature: HIF 1alpha s2 sa2 rs4
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 158
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PIP2
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot A0A2I3T9Y4 57
organism: Pan troglodytes

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 38

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PIP2-RIGHT__ADP-_PIP3-_r21
controller: PI3 Kinase

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 47

uniprot Q9VK45 46
type: UnificationXref
id: Q9VK45
db: uniprot

uniprot F6RRA8 10
type: UnificationXref
id: F6RRA8
db: uniprot

ncbitaxon 1111708 144
type: UnificationXref
id: 1111708
db: ncbitaxon

uniprot F1MYJ4 63
type: UnificationXref
id: F1MYJ4
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot O08586 114
xref: PTHR12305:SF81
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r21 192
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r21 193
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

PTHR24356:SF190
type: RelationshipXref
id: PTHR24356:SF190
db: PANTHER Family
relationship type: By Homology

TRANSCRIPTION_LEFT__HRE_gene_high_transcription-RIGHT__HRE_gene_high_transcription-_re22
type: TemplateReaction
product: HRE gene/high transcription
xref: TRANSCRIPTION
participant: HRE gene/high transcription
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Thioredoxin
type: ProteinReference
xref: P00825
standard name: thioredoxin
comment: ENTITY_REFERENCE_NOTES=Long Name: thioredoxin Synonym: Synonym not specified Accession: P00825
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Hypoxia response via HIF activation.PROTEIN.GENERIC.Thioredoxin
member entity reference: Thioredoxin
member entity reference: Thioredoxin-1
member entity reference: Thioredoxin, mitochondrial
member entity reference: Thioredoxin 1
member entity reference: Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

AKT
type: Protein
entity reference: AKT
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

P300
type: ProteinReference
xref: P00814
standard name: p300
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: p300 Synonym: CREB binding protein (CBP),EIA binding protein p300 Accession: P00814
comment: ENTITY_REFERENCE_ID_DESC=Hypoxia response via HIF activation.PROTEIN.GENERIC.P300
member entity reference: CREB-binding protein
member entity reference: CREB binding protein
member entity reference: Uncharacterized protein
member entity reference: CREB-binding protein isoform a

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A
type: ProteinReference
xref: uniprot Q9LT75 122
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r21 190
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r21 191
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: uniprot P42345 40
xref: PTHR11139:SF9
organism: Homo sapiens

uniprot P42345 40
type: UnificationXref
id: P42345
db: uniprot

ncbitaxon 9606 22
type: UnificationXref
id: 9606
db: ncbitaxon

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 147

uniprot P29429 138
type: UnificationXref
id: P29429
db: uniprot

ncbitaxon 44689 121
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot H2QXP0 128
type: UnificationXref
id: H2QXP0
db: uniprot

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: uniprot Q16665 55
xref: PTHR23043:SF7
organism: Homo sapiens

eco ECO:0000305 82
type: UnificationXref
id: ECO:0000305
db: eco

Thioredoxin
type: ProteinReference
xref: uniprot Q9X2T1 155
organism: Pseudomonas aeruginosa

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: uniprot H9ENS2 33
xref: PTHR11139:SF9
organism: Macaca mulatta

uniprot O35800 54
type: UnificationXref
id: O35800
db: uniprot

HIF-1beta
type: ProteinReference
xref: P00820
standard name: hypoxia inducible factor-1-beta
comment: ENTITY_REFERENCE_ID_DESC=Hypoxia response via HIF activation.PROTEIN.GENERIC.HIF-1_beta
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: hypoxia inducible factor-1-beta Synonym: TANGO,aryl hydrocarbon receptor nuclear translocator (ARNT),dioxin receptor nuclear translocator Accession: P00820
member entity reference: Aryl hydrocarbon receptor nuclear translocator
member entity reference: Uncharacterized protein

uniprot F1NT98 112
type: UnificationXref
id: F1NT98
db: uniprot

Thioredoxin
type: ProteinReference
xref: uniprot Q7KQL8 146
organism: Plasmodium falciparum

HIF 1alpha s9 sa6 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

von Hippel-Lindau disease tumor suppressor
type: ProteinReference
xref: PTHR15160:SF1
xref: uniprot Q64259 26
organism: Rattus norvegicus

ncbitaxon 7165 85
type: UnificationXref
id: 7165
db: ncbitaxon

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 15

uniprot Q91UZ4 103
type: UnificationXref
id: Q91UZ4
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 71

von Hippel-Lindau disease tumor suppressor
type: ProteinReference
xref: PTHR15160:SF1
xref: uniprot P40337 23
organism: Homo sapiens

uniprot P60484 118
type: UnificationXref
id: P60484
db: uniprot

von Hippel-Lindau disease tumor suppressor
type: ProteinReference
xref: PTHR15160:SF1
xref: uniprot P40338 25
organism: Mus musculus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Metabolism Genes Increased Glycolysis
controller: HRE gene/high transcription

OH
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 160
cellular location: cytosol
comment: SPECIES_TYPE=ION

P300
type: Protein
entity reference: P300
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa7 170
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PTHR24356:SF333
type: RelationshipXref
id: PTHR24356:SF333
db: PANTHER Family
relationship type: By Homology

uniprot F1PY87 8
type: UnificationXref
id: F1PY87
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MDX9 111
xref: PTHR12305:SF81
organism: Bos taurus

By Homology
type: RelationshipTypeVocabulary

Thioredoxin
type: ProteinReference
xref: PTHR10438:SF18
xref: uniprot P11232 135
organism: Rattus norvegicus

uniprot F1MDX9 111
type: UnificationXref
id: F1MDX9
db: uniprot

uniprot Q96KS0 106
type: UnificationXref
id: Q96KS0
db: uniprot

uniprot F6XP81 70
type: UnificationXref
id: F6XP81
db: uniprot

uniprot F7GZS9 32
type: UnificationXref
id: F7GZS9
db: uniprot

ncbitaxon 8364 71
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot P40338 25
type: UnificationXref
id: P40338
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__HIF_1alpha-_P300-_HIF_1beta-RIGHT__Complex__HIF_1_beta_HIF_1_alpha__P300_-_r52
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 176
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 177
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 178
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 175
left: HIF-1alpha
left: P300
left: HIF-1beta
interaction type: HETERODIMER_ASSOCIATION
right: Complex (HIF-1_beta/HIF-1_alpha/ P300)

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: uniprot F7BA89 31
xref: PTHR11139:SF9
organism: Monodelphis domestica

uniprot A0A3Q2U4X3 59
type: UnificationXref
id: A0A3Q2U4X3
db: uniprot

Complex (OH/HIF-1_alpha)
type: Complex
component stoichiometry: HIF 1alpha s2 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: OH s1 sa1 STOICHIOMETRY ID COMPLEX
component: HIF-1alpha
component: OH
feature: COMPLEX BINDING FEATURE s45 a53 157
feature: COMPLEX BINDING FEATURE s45 a53 159
cellular location: cytosol

Complex (HIF-1_beta/HIF-1_alpha/ P300)
type: Complex
component stoichiometry: HIF 1beta s8 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: P300 s10 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: HIF 1alpha s9 sa6 STOICHIOMETRY ID COMPLEX
component: HIF-1beta
component: P300
component: HIF-1alpha
feature: ACTIVE 48
feature: COMPLEX BINDING FEATURE s59 a70 165
feature: COMPLEX BINDING FEATURE s59 a70 167
feature: COMPLEX BINDING FEATURE s59 a70 169
cellular location: nucleus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot E7EXT6 61
organism: Danio rerio

uniprot H2Q856 101
type: UnificationXref
id: H2Q856
db: uniprot

Hypoxia response via HIF activation
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__HIF_1alpha-_P300-_HIF_1beta-RIGHT__Complex__HIF_1_beta_HIF_1_alpha__P300_-_r52
pathway component: STATE_TRANSITION_LEFT__ATP-_PIP2-RIGHT__ADP-_PIP3-_r21
pathway component: STATE_TRANSITION_LEFT__ATP-_TOR-RIGHT__ADP-_TOR-_r22
pathway component: TRANSCRIPTION_LEFT__HRE_gene_high_transcription-RIGHT__HRE_gene_high_transcription-_re22
pathway component: STATE_TRANSITION_LEFT__Complex__HIF_1_alpha_OH_-RIGHT__a64_degraded-_r50
pathway component: STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_r26
pathway component: STATE_TRANSITION_LEFT__REF_1-RIGHT__REF_1-_re20
pathway component: PHYSICAL_STIMULATION
pathway component: TRANSCRIPTION_LEFT__HRE_gene_low_transcription-RIGHT__HRE_gene_low_transcription-_re21
pathway component: STATE_TRANSITION_LEFT__Ub-_Complex__OH_HIF_1_alpha_-_VHL-RIGHT__Complex__HIF_1_alpha_OH_-_VHL-_r49
pathway component: UNKNOWN_TRANSITION_LEFT__PI3_Kinase-RIGHT__PI3_Kinase-_r30
pathway component: STATE_TRANSITION_LEFT__HIF_1alpha-RIGHT__HIF_1alpha-_r25
pathway component: TRANSPORT_LEFT__Thioredoxin-RIGHT__Thioredoxin-_r45
pathway component: STATE_TRANSITION_LEFT__Prolyl_Hydroxylase-RIGHT__Prolyl_Hydroxylase-_re19
pathway component: STATE_TRANSITION_LEFT__OH-_HIF_1alpha-RIGHT__Complex__OH_HIF_1_alpha_-_r31
xref: PANTHER Pathway P00030 1
comment: MODEL_NOTES=Panther Pathway: P00030 This pathway illustrates the intracellular signaling responses to hypoxia. Medline=13130303 Medline=14526383 Medline=14988927 PMID: 13130303 PMID: 14526383 PMID: 14988927

uniprot F7HPH6 99
type: UnificationXref
id: F7HPH6
db: uniprot

ncbitaxon 227321 139
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot F1PZ54 51
type: UnificationXref
id: F1PZ54
db: uniprot

ncbitaxon 224324 130
type: UnificationXref
id: 224324
db: ncbitaxon

Egl nine homolog 2
type: ProteinReference
xref: uniprot Q91YE2 104
xref: PTHR12907:SF6
organism: Mus musculus

Egl nine homolog 1
type: ProteinReference
xref: uniprot Q91YE3 105
xref: PTHR12907:SF4
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__OH-_HIF_1alpha-RIGHT__Complex__OH_HIF_1_alpha_-_r31
controller: Prolyl Hydroxylase

HIF 1alpha s3 a11 rs4
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Hypoxia inducible factor 1 subunit alpha
type: ProteinReference
xref: uniprot F1PZ54 51
xref: PTHR23043:SF7
organism: Canis lupus familiaris

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6QP11 67
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VBA7 113
xref: PTHR12305:SF81
organism: Macaca mulatta

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: PTHR23043:SF7
xref: uniprot O35800 54
organism: Rattus norvegicus

Egl nine homolog 2
type: ProteinReference
xref: uniprot Q96KS0 106
xref: PTHR12907:SF6
organism: Homo sapiens

uniprot P14949 136
type: UnificationXref
id: P14949
db: uniprot

HIF-1alpha
type: Protein
entity reference: HIF-1alpha
feature: HIF 1alpha s9 sa6 rs4
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa6 168
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__ATP-_TOR-RIGHT__ADP-_TOR-_r22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 187
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 186
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 185
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 184
left: TOR
left: ATP
interaction type: STATE_TRANSITION
right: TOR
right: ADP

HIF-1alpha
type: Protein
entity reference: HIF-1alpha
feature: ACTIVE 48
feature: HIF 1alpha s3 a11 rs4
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTEN
type: Protein
entity reference: PTEN
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Thioredoxin
type: ProteinReference
xref: PTHR10438:SF18
xref: uniprot P10639 134
organism: Mus musculus

eco ECO:0000304 24
type: UnificationXref
id: ECO:0000304
db: eco

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot Q9Y243 89
organism: Homo sapiens

uniprot F1PRG4 64
type: UnificationXref
id: F1PRG4
db: uniprot

ncbitaxon 9031 30
type: UnificationXref
id: 9031
db: ncbitaxon

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot P60484 118
xref: PTHR12305:SF81
organism: Homo sapiens

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ub
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot P60483 117
xref: PTHR12305:SF81
organism: Canis lupus familiaris

a64_degraded
type: PhysicalEntity
cellular location: cytosol
comment: SPECIES_TYPE=DEGRADED

HRE gene/high transcription
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

uniprot F6ZT25 96
type: UnificationXref
id: F6ZT25
db: uniprot

TOR
type: ProteinReference
xref: P00817
standard name: mammalian target of rapamycin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: mammalian target of rapamycin Synonym: FRAP1, FK506 binding protein 12-rapamycin associated protein 1,FRAP2,RAFT1,RAPT2 Accession: P00817
comment: ENTITY_REFERENCE_ID_DESC=Hypoxia response via HIF activation.PROTEIN.GENERIC.TOR
member entity reference: Serine/threonine-protein kinase Tor
member entity reference: Serine/threonine-protein kinase TOR
member entity reference: Serine/threonine-protein kinase mTOR
member entity reference: Serine/threonine-protein kinase tor1
member entity reference: Serine/threonine-protein kinase TOR1
member entity reference: Serine/threonine-protein kinase TOR2
member entity reference: Uncharacterized protein
member entity reference: Nuclear receptor ROR-gamma

uniprot B7PXT0 124
type: UnificationXref
id: B7PXT0
db: uniprot

Thioredoxin
type: ProteinReference
xref: uniprot Q8TL30 148
organism: Methanosarcina acetivorans

PTHR11139:SF9
type: RelationshipXref
id: PTHR11139:SF9
db: PANTHER Family
relationship type: By Homology

uniprot P47196 78
type: UnificationXref
id: P47196
db: uniprot

Prolyl Hydroxylase
type: Protein
entity reference: Prolyl Hydroxylase
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

UNKNOWN_TRANSITION_LEFT__PI3_Kinase-RIGHT__PI3_Kinase-_r30
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 203
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 204
left: PI3 Kinase
interaction type: UNKNOWN_TRANSITION
right: PI3 Kinase

PARTICIPANT STOICHIOMETRY r31 202
type: Stoichiometry
physical entity: Complex (OH/HIF-1_alpha)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r31 201
type: Stoichiometry
physical entity: HIF-1alpha
stoichiometric coefficient: 1.0

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P31751 77
organism: Homo sapiens

uniprot P47938 140
type: UnificationXref
id: P47938
db: uniprot

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 137

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31750 76
xref: PTHR24356:SF171
organism: Mus musculus

Putative tyrosine-protein phosphatase TPTE
type: ProteinReference
xref: uniprot P56180 116
organism: Homo sapiens

Aryl hydrocarbon receptor nuclear translocator
type: ProteinReference
xref: uniprot P27540 92
xref: PTHR23042:SF50
organism: Homo sapiens

Bos taurus
type: BioSource
xref: ncbitaxon 9913 5

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q9WUA6 88
xref: PTHR24356:SF190
organism: Mus musculus

UNKNOWN_TRANSITION
type: InteractionVocabulary

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 11

HIF 1alpha s4 sa3 rs4
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

00696
type: UnificationXref
id: MOD:00696
db: mod

Thioredoxin 1
type: ProteinReference
xref: uniprot Q9RYY9 152
organism: Deinococcus radiodurans

IP16020p
type: ProteinReference
xref: uniprot Q7KMQ6 119
xref: PTHR12305:SF81
organism: Drosophila melanogaster

P00825
type: UnificationXref
id: P00825
db: PANTHER Pathway Component

PI3 Kinase
type: Protein
feature: ACTIVE 48
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HIF-1alpha
type: ProteinReference
xref: P00818
standard name: Hypoxia inducible factor-1 alpha subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Hypoxia response via HIF activation.PROTEIN.GENERIC.HIF-1_alpha
comment: ENTITY_REFERENCE_NOTES=Long Name: Hypoxia inducible factor-1 alpha subunit Synonym: MOP1 Accession: P00818
member entity reference: Uncharacterized protein
member entity reference: Hypoxia-inducible factor 1-alpha
member entity reference: Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor)
member entity reference: HIF1A isoform 7
member entity reference: Hypoxia inducible factor 1 subunit alpha

P00824
type: UnificationXref
id: P00824
db: PANTHER Pathway Component

P00821
type: UnificationXref
id: P00821
db: PANTHER Pathway Component

P00820
type: UnificationXref
id: P00820
db: PANTHER Pathway Component

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31749 75
xref: PTHR24356:SF171
organism: Homo sapiens

ncbitaxon 6945 125
type: UnificationXref
id: 6945
db: ncbitaxon

Egl nine homolog 2
type: ProteinReference
xref: PTHR12907:SF6
xref: uniprot Q6AYU4 102
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E905 12
xref: PTHR13808:SF34
organism: Monodelphis domestica

Thioredoxin, mitochondrial
type: ProteinReference
xref: uniprot Q99757 150
xref: PTHR43601:SF3
organism: Homo sapiens

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot B1H2U0 110
xref: PTHR12305:SF81
organism: Xenopus tropicalis

Increased Angiogenesis
type: Pathway

Thioredoxin-1
type: ProteinReference
xref: uniprot P47938 140
xref: PTHR10438:SF423
organism: Drosophila melanogaster

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 149

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 125

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: UNKNOWN_TRANSITION_LEFT__PI3_Kinase-RIGHT__PI3_Kinase-_r30
control type: ACTIVATION
controller: Hypoxia

uniprot Q91YE2 104
type: UnificationXref
id: Q91YE2
db: uniprot

ncbitaxon 10116 20
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot O08586 114
type: UnificationXref
id: O08586
db: uniprot

uniprot P56180 116
type: UnificationXref
id: P56180
db: uniprot

uniprot P10599 133
type: UnificationXref
id: P10599
db: uniprot

PTHR43601:SF3
type: RelationshipXref
id: PTHR43601:SF3
db: PANTHER Family
relationship type: By Homology

TOR
type: Protein
entity reference: TOR
feature: TOR s33 a41 rs1
feature: ACTIVE 48
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Pro-apoptotic genes
type: Pathway

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 130

uniprot Q16665 55
type: UnificationXref
id: Q16665
db: uniprot

PTHR15160:SF1
type: RelationshipXref
id: PTHR15160:SF1
db: PANTHER Family
relationship type: By Homology

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 9

STATE_TRANSITION_LEFT__REF_1-RIGHT__REF_1-_re20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 199
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 198
left: REF-1
interaction type: STATE_TRANSITION
right: REF-1

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZT25 96
xref: PTHR12907:SF5
organism: Monodelphis domestica

uniprot A0A2I3T9Y4 57
type: UnificationXref
id: A0A2I3T9Y4
db: uniprot

RAC serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q8INB9 86
xref: PTHR24356:SF333
organism: Drosophila melanogaster

CREB binding protein
type: ProteinReference
xref: PTHR13808:SF34
xref: uniprot F1MD32 4
organism: Bos taurus

uniprot K7CDC2 74
type: UnificationXref
id: K7CDC2
db: uniprot

ncbitaxon 10090 17
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot P51449 42
type: UnificationXref
id: P51449
db: uniprot

AKT
type: ProteinReference
xref: P00819
standard name: protein kinase B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Hypoxia response via HIF activation.PROTEIN.GENERIC.AKT
comment: ENTITY_REFERENCE_NOTES=Long Name: v-akt murine thymoma viral oncogene homolog 1 Synonym: PRKBA,RAC-alpha serine/threonine-protein kinase (RAC-PK-alpha) ,Thymoma viral proto-oncogene,protein kinase B (PKB) Accession: P00819
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC-beta serine/threonine-protein kinase
member entity reference: RAC-gamma serine/threonine-protein kinase
member entity reference: RAC-alpha serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase akt-1
member entity reference: RAC serine/threonine-protein kinase

uniprot F7BA89 31
type: UnificationXref
id: F7BA89
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 30

Thioredoxin
type: ProteinReference
xref: uniprot P29429 138
organism: Emericella nidulans

HIF 1alpha s9 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: HIF-1alpha
stoichiometric coefficient: 1.0

uniprot F7HKJ2 52
type: UnificationXref
id: F7HKJ2
db: uniprot

uniprot P31750 76
type: UnificationXref
id: P31750
db: uniprot

uniprot K7B4P2 34
type: UnificationXref
id: K7B4P2
db: uniprot

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 142

PTHR10438:SF18
type: RelationshipXref
id: PTHR10438:SF18
db: PANTHER Family
relationship type: By Homology

PIP3
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

INHIBITION
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__HIF_1alpha-_P300-_HIF_1beta-RIGHT__Complex__HIF_1_beta_HIF_1_alpha__P300_-_r52
control type: INHIBITION
controller: IPAS

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot K7DBC8 14
type: UnificationXref
id: K7DBC8
db: uniprot

ncbitaxon 13616 13
type: UnificationXref
id: 13616
db: ncbitaxon

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: uniprot K7B4P2 34
xref: PTHR11139:SF9
organism: Pan troglodytes

Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
type: ProteinReference
xref: uniprot Q9TW67 154
organism: Caenorhabditis elegans

uniprot A0A3Q1LUX2 94
type: UnificationXref
id: A0A3Q1LUX2
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__ATP-_PIP2-RIGHT__ADP-_PIP3-_r21
control type: INHIBITION
controller: PTEN

ncbitaxon 208964 156
type: UnificationXref
id: 208964
db: ncbitaxon

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q2U4X3 59
xref: PTHR24356:SF171
organism: Gallus gallus

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot A0A2I3TNH3 109
xref: PTHR12305:SF81
organism: Pan troglodytes

Egl nine homolog 2
type: ProteinReference
xref: uniprot F7DAI9 98
xref: PTHR12907:SF6
organism: Macaca mulatta

uniprot P42346 41
type: UnificationXref
id: P42346
db: uniprot

uniprot Q99757 150
type: UnificationXref
id: Q99757
db: uniprot

CREB binding protein
type: ProteinReference
xref: uniprot F1PY87 8
xref: PTHR13808:SF34
organism: Canis lupus familiaris

Nuclear receptor ROR-gamma
type: ProteinReference
xref: uniprot P51449 42
organism: Homo sapiens

uniprot H2R3D7 90
type: UnificationXref
id: H2R3D7
db: uniprot

STATE_TRANSITION_LEFT__Prolyl_Hydroxylase-RIGHT__Prolyl_Hydroxylase-_re19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 196
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 197
left: Prolyl Hydroxylase
interaction type: STATE_TRANSITION
right: Prolyl Hydroxylase

P300 s10 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: P300
stoichiometric coefficient: 1.0

ncbitaxon 9544 11
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot F6VBA7 113
type: UnificationXref
id: F6VBA7
db: uniprot

uniprot O67747 129
type: UnificationXref
id: O67747
db: uniprot

P00817
type: UnificationXref
id: P00817
db: PANTHER Pathway Component

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q8UUX0 87
organism: Danio rerio

uniprot B1H2U0 110
type: UnificationXref
id: B1H2U0
db: uniprot

P00818
type: UnificationXref
id: P00818
db: PANTHER Pathway Component

Serine/threonine-protein kinase TOR
type: ProteinReference
xref: uniprot Q5KEY7 43
xref: PTHR11139:SF9
organism: Cryptococcus neoformans

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__REF_1-RIGHT__REF_1-_re20
control type: ACTIVATION
controller: Thioredoxin

P00816
type: UnificationXref
id: P00816
db: PANTHER Pathway Component

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 81

P00819
type: UnificationXref
id: P00819
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: PTHR12907:SF6
xref: uniprot A0A3Q1LUX2 94
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F6R8N3 68
organism: Macaca mulatta

HIF1A isoform 7
type: ProteinReference
xref: uniprot H2Q8F3 53
xref: PTHR23043:SF7
organism: Pan troglodytes

P00814
type: UnificationXref
id: P00814
db: PANTHER Pathway Component

uniprot P11232 135
type: UnificationXref
id: P11232
db: uniprot

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P47196 78
organism: Rattus norvegicus

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P47197 79
organism: Rattus norvegicus

Thioredoxin
type: ProteinReference
xref: PTHR10438:SF18
xref: uniprot H2QXP0 128
organism: Pan troglodytes

STATE_TRANSITION_LEFT__Ub-_Complex__OH_HIF_1_alpha_-_VHL-RIGHT__Complex__HIF_1_alpha_OH_-_VHL-_r49
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 182
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 183
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 181
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 179
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 180
left: Complex (OH/HIF-1_alpha)
left: VHL
left: Ub
interaction type: STATE_TRANSITION
right: VHL
right: Complex (HIF-1_alpha/OH)

uniprot Q6AYU4 102
type: UnificationXref
id: Q6AYU4
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Pro-apoptotic genes
controller: HRE gene/high transcription

PARTICIPANT STOICHIOMETRY r31 200
type: Stoichiometry
physical entity: OH
stoichiometric coefficient: 1.0

P300
type: Protein
entity reference: P300
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9598 15
type: UnificationXref
id: 9598
db: ncbitaxon

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 156

Serine/threonine-protein kinase tor1
type: ProteinReference
xref: uniprot O14356 35
organism: Schizosaccharomyces pombe

OH s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: OH
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION
type: RelationshipTypeVocabulary

PANTHER Pathway P00030 1
type: UnificationXref
id: P00030
db: PANTHER Pathway

PTEN
type: ProteinReference
xref: P00824
standard name: phospatase and tensin homologue
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Hypoxia response via HIF activation.PROTEIN.GENERIC.PTEN
comment: ENTITY_REFERENCE_NOTES=Long Name: phospatase and tensin homologue Synonym: BZS,MHAM,MMAC1,TEP1 Accession: P00824
member entity reference: Uncharacterized protein
member entity reference: IP16020p
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A
member entity reference: Putative tyrosine-protein phosphatase TPTE

PARTICIPANT STOICHIOMETRY r49 179
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F7GEK1 72
organism: Monodelphis domestica

Thioredoxin-1
type: ProteinReference
xref: uniprot Q09433 145
organism: Caenorhabditis elegans

uniprot P35169 39
type: UnificationXref
id: P35169
db: uniprot

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: uniprot Q9JLN9 45
xref: PTHR11139:SF9
organism: Mus musculus

uniprot Q9TW67 154
type: UnificationXref
id: Q9TW67
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__HRE_gene_high_transcription-RIGHT__HRE_gene_high_transcription-_re22
control type: ACTIVATION
controller: HRE gene/low transcription

ncbitaxon 6239 81
type: UnificationXref
id: 6239
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_r26
controller: PIP3

TRANSPORT
type: RelationshipTypeVocabulary

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 85

uniprot P45481 16
type: UnificationXref
id: P45481
db: uniprot

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 44

uniprot Q8INB9 86
type: UnificationXref
id: Q8INB9
db: uniprot

PTHR12305:SF81
type: RelationshipXref
id: PTHR12305:SF81
db: PANTHER Family
relationship type: By Homology

TRANSCRIPTION_LEFT__HRE_gene_low_transcription-RIGHT__HRE_gene_low_transcription-_re21
type: TemplateReaction
product: HRE gene/low transcription
xref: TRANSCRIPTION
participant: HRE gene/low transcription
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PARTICIPANT STOICHIOMETRY r49 180
type: Stoichiometry
physical entity: Complex (OH/HIF-1_alpha)
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__HRE_gene_high_transcription-RIGHT__HRE_gene_high_transcription-_re22
control type: ACTIVATION
controller: Complex (HIF-1_beta/HIF-1_alpha/ P300)

PARTICIPANT STOICHIOMETRY r49 182
type: Stoichiometry
physical entity: Complex (HIF-1_alpha/OH)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r49 181
type: Stoichiometry
physical entity: VHL
stoichiometric coefficient: 1.0

TOR s32 a40 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_SIDE=inside
comment: MODIFICATION_RESIDUE_ANGLE=0.57

HIF-1beta
type: Protein
entity reference: HIF-1beta
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa5 166
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r49 183
type: Stoichiometry
physical entity: VHL
stoichiometric coefficient: 1.0

Aryl hydrocarbon receptor nuclear translocator
type: ProteinReference
xref: PTHR23042:SF50
xref: uniprot Q9BE97 93
organism: Bos taurus

uniprot A7MBA0 95
type: UnificationXref
id: A7MBA0
db: uniprot

HIF 1beta s8 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: HIF-1beta
stoichiometric coefficient: 1.0

Thioredoxin
type: ProteinReference
xref: PTHR10438:SF18
xref: uniprot F6RHG3 126
organism: Macaca mulatta

VHL
type: ProteinReference
xref: P00816
standard name: Von Hippel Lindau protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Hypoxia response via HIF activation.PROTEIN.GENERIC.VHL
comment: ENTITY_REFERENCE_NOTES=Long Name: Von Hippel Lindau protein Synonym: elongin binding protein Accession: P00816
member entity reference: von Hippel-Lindau disease tumor suppressor

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q60823 83
organism: Mus musculus

uniprot P08629 132
type: UnificationXref
id: P08629
db: uniprot

uniprot Q9NGZ1 151
type: UnificationXref
id: Q9NGZ1
db: uniprot

ncbitaxon 9615 9
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot F7DAI9 98
type: UnificationXref
id: F7DAI9
db: uniprot

HIF 1alpha s4 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: HIF-1alpha
stoichiometric coefficient: 1.0

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 144

PARTICIPANT STOICHIOMETRY r30 204
type: Stoichiometry
physical entity: PI3 Kinase
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r30 203
type: Stoichiometry
physical entity: PI3 Kinase
stoichiometric coefficient: 1.0

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

HRE gene/low transcription
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Egl nine homolog 3
type: ProteinReference
xref: PTHR12907:SF5
xref: uniprot Q91UZ4 103
organism: Mus musculus

Thioredoxin
type: ProteinReference
xref: uniprot P14949 136
organism: Bacillus subtilis

PTHR12907:SF6
type: RelationshipXref
id: PTHR12907:SF6
db: PANTHER Family
relationship type: By Homology

uniprot Q7KQL8 146
type: UnificationXref
id: Q7KQL8
db: uniprot

Egl nine homolog 1
type: ProteinReference
xref: uniprot Q9GZT9 107
xref: PTHR12907:SF4
organism: Homo sapiens

uniprot Q9X2T1 155
type: UnificationXref
id: Q9X2T1
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 13

PTHR12907:SF4
type: RelationshipXref
id: PTHR12907:SF4
db: PANTHER Family
relationship type: By Homology

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

PTHR12907:SF5
type: RelationshipXref
id: PTHR12907:SF5
db: PANTHER Family
relationship type: By Homology

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Prolyl_Hydroxylase-RIGHT__Prolyl_Hydroxylase-_re19
control type: INHIBITION
controller: Hypoxia

ncbitaxon 243230 153
type: UnificationXref
id: 243230
db: ncbitaxon

uniprot A0A3Q1NH21 58
type: UnificationXref
id: A0A3Q1NH21
db: uniprot

Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor)
type: ProteinReference
xref: uniprot A0JND0 49
xref: PTHR23043:SF7
organism: Bos taurus

CREB-binding protein
type: ProteinReference
xref: uniprot Q92793 21
xref: PTHR13808:SF34
organism: Homo sapiens

uniprot Q7QK56 84
type: UnificationXref
id: Q7QK56
db: uniprot

uniprot P10639 134
type: UnificationXref
id: P10639
db: uniprot

uniprot P32600 37
type: UnificationXref
id: P32600
db: uniprot

STATE_TRANSITION_LEFT__ATP-_PIP2-RIGHT__ADP-_PIP3-_r21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 193
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 192
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 191
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 190
left: PIP2
left: ATP
interaction type: STATE_TRANSITION
right: PIP3
right: ADP

HIF-1alpha
type: Protein
entity reference: HIF-1alpha
feature: HIF 1alpha s4 sa3 rs4
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa3 162
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

OH
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa4 164
cellular location: cytosol
comment: SPECIES_TYPE=ION

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 36

uniprot Q9BE97 93
type: UnificationXref
id: Q9BE97
db: uniprot

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: uniprot Q61221 56
xref: PTHR23043:SF7
organism: Mus musculus

GO GO:0005634 3
type: UnificationXref
id: GO:0005634
db: GO

Thioredoxin
type: ProteinReference
xref: PTHR10438:SF18
xref: uniprot F7H2R2 127
organism: Macaca mulatta

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F6QE96 66
organism: Macaca mulatta

IPAS
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TRANSCRIPTION
type: InteractionVocabulary

Hypoxia
type: PhysicalEntity
comment: SPECIES_TYPE=UNKNOWN

uniprot F1NJK2 50
type: UnificationXref
id: F1NJK2
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F1PRG4 64
organism: Canis lupus familiaris

Serine/threonine-protein kinase TOR
type: ProteinReference
xref: uniprot F1NUX4 29
xref: PTHR11139:SF9
organism: Gallus gallus

Thioredoxin
type: Protein
entity reference: Thioredoxin
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CREB-binding protein
type: ProteinReference
xref: uniprot Q6JHU9 19
xref: PTHR13808:SF34
organism: Rattus norvegicus

HIF-1alpha
type: Protein
entity reference: HIF-1alpha
feature: HIF 1alpha s42 a42 rs4
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__HIF_1alpha-RIGHT__HIF_1alpha-_r25
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 173
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 174
left: HIF-1alpha
interaction type: STATE_TRANSITION
right: HIF-1alpha

Prolyl Hydroxylase
type: Protein
entity reference: Prolyl Hydroxylase
feature: ACTIVE 48
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2Q8F3 53
type: UnificationXref
id: H2Q8F3
db: uniprot

uniprot E2R2L2 28
type: UnificationXref
id: E2R2L2
db: uniprot

TOR s33 a41 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_SIDE=inside
comment: MODIFICATION_RESIDUE_ANGLE=0.57

uniprot Q5KEY7 43
type: UnificationXref
id: Q5KEY7
db: uniprot

ncbitaxon 284812 36
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot P47197 79
type: UnificationXref
id: P47197
db: uniprot

Prolyl Hydroxylase
type: ProteinReference
xref: P00821
standard name: HIF-1 alpha prolyl hydroxylase 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: HIF-1 alpha prolyl hydroxylase 2 Synonym: EGL nine homolog,HPH-2,PHD2 Accession: P00821
comment: ENTITY_REFERENCE_ID_DESC=Hypoxia response via HIF activation.PROTEIN.GENERIC.Prolyl_br_Hydroxylase
member entity reference: Egl nine homolog 2
member entity reference: EGLN3 protein
member entity reference: Uncharacterized protein
member entity reference: Egl nine homolog 3
member entity reference: Egl nine homolog 1
member entity reference: EGLN3 isoform 1

PARTICIPANT STOICHIOMETRY r50 189
type: Stoichiometry
physical entity: a64_degraded
stoichiometric coefficient: 1.0

uniprot F6R8N3 68
type: UnificationXref
id: F6R8N3
db: uniprot

PARTICIPANT STOICHIOMETRY r50 188
type: Stoichiometry
physical entity: Complex (HIF-1_alpha/OH)
stoichiometric coefficient: 1.0

Thioredoxin
type: Protein
entity reference: Thioredoxin
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q91YE3 105
type: UnificationXref
id: Q91YE3
db: uniprot

OH
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

uniprot Q17941 80
type: UnificationXref
id: Q17941
db: uniprot

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 153

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 22

PI3 Kinase
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q7KMQ6 119
type: UnificationXref
id: Q7KMQ6
db: uniprot

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: uniprot F1NJK2 50
organism: Gallus gallus

uniprot Q64259 26
type: UnificationXref
id: Q64259
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GZS9 32
organism: Macaca mulatta

uniprot E1BFB4 27
type: UnificationXref
id: E1BFB4
db: uniprot

uniprot F6QP11 67
type: UnificationXref
id: F6QP11
db: uniprot

PTHR23043:SF7
type: RelationshipXref
id: PTHR23043:SF7
db: PANTHER Family
relationship type: By Homology

uniprot Q8UUX0 87
type: UnificationXref
id: Q8UUX0
db: uniprot

uniprot Q92793 21
type: UnificationXref
id: Q92793
db: uniprot

Egl nine homolog 3
type: ProteinReference
xref: uniprot F7HPH6 99
xref: PTHR12907:SF5
organism: Macaca mulatta

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 123

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q1NH21 58
xref: PTHR24356:SF176
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r25 173
type: Stoichiometry
physical entity: HIF-1alpha
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase TOR2
type: ProteinReference
xref: uniprot P32600 37
xref: PTHR11139:SF9
organism: Saccharomyces cerevisiae

STATE_TRANSITION_LEFT__Complex__HIF_1_alpha_OH_-RIGHT__a64_degraded-_r50
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 188
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 189
left: Complex (HIF-1_alpha/OH)
interaction type: STATE_TRANSITION
right: a64_degraded

Metabolism Genes Increased Glycolysis
type: Pathway

Thioredoxin
type: ProteinReference
xref: uniprot P52231 143
organism: Synechocystis

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot K7CDC2 74
xref: PTHR24356:SF176
organism: Pan troglodytes

ncbitaxon 36329 147
type: UnificationXref
id: 36329
db: ncbitaxon

Thioredoxin 1
type: ProteinReference
xref: uniprot P52230 141
organism: Streptomyces coelicolor

uniprot Q09433 145
type: UnificationXref
id: Q09433
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 62

uniprot E7EXT6 61
type: UnificationXref
id: E7EXT6
db: uniprot

PARTICIPANT STOICHIOMETRY r22 185
type: Stoichiometry
physical entity: TOR
stoichiometric coefficient: 1.0

uniprot O97680 131
type: UnificationXref
id: O97680
db: uniprot

PARTICIPANT STOICHIOMETRY r22 184
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 187
type: Stoichiometry
physical entity: TOR
stoichiometric coefficient: 1.0

uniprot F7GEK1 72
type: UnificationXref
id: F7GEK1
db: uniprot

CREB binding protein
type: ProteinReference
xref: uniprot K7DBC8 14
xref: PTHR13808:SF34
organism: Pan troglodytes

uniprot P40337 23
type: UnificationXref
id: P40337
db: uniprot

PARTICIPANT STOICHIOMETRY r22 186
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Egl nine homolog 3
type: ProteinReference
xref: PTHR12907:SF5
xref: uniprot Q9H6Z9 108
organism: Homo sapiens

uniprot F1NUX4 29
type: UnificationXref
id: F1NUX4
db: uniprot

PARTICIPANT STOICHIOMETRY re20 199
type: Stoichiometry
physical entity: REF-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re20 198
type: Stoichiometry
physical entity: REF-1
stoichiometric coefficient: 1.0

AKT
type: Protein
entity reference: AKT
feature: ACTIVE 48
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9GZT9 107
type: UnificationXref
id: Q9GZT9
db: uniprot

uniprot O14356 35
type: UnificationXref
id: O14356
db: uniprot

uniprot J9P204 91
type: UnificationXref
id: J9P204
db: uniprot

PTHR23042:SF50
type: RelationshipXref
id: PTHR23042:SF50
db: PANTHER Family
relationship type: By Homology

Egl nine homolog 2
type: ProteinReference
xref: uniprot G2HG38 100
xref: PTHR12907:SF6
organism: Pan troglodytes

HIF 1alpha s42 a42 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.59
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

TRANSCRIPTION
type: RelationshipTypeVocabulary

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HKJ2 52
xref: PTHR23043:SF7
organism: Macaca mulatta

uniprot H9ENS2 33
type: UnificationXref
id: H9ENS2
db: uniprot

uniprot A0A2I3TNH3 109
type: UnificationXref
id: A0A2I3TNH3
db: uniprot

uniprot P52231 143
type: UnificationXref
id: P52231
db: uniprot

PARTICIPANT STOICHIOMETRY r52 176
type: Stoichiometry
physical entity: P300
stoichiometric coefficient: 1.0

uniprot Q9Y243 89
type: UnificationXref
id: Q9Y243
db: uniprot

PARTICIPANT STOICHIOMETRY r52 177
type: Stoichiometry
physical entity: HIF-1beta
stoichiometric coefficient: 1.0

uniprot Q9H6Z9 108
type: UnificationXref
id: Q9H6Z9
db: uniprot

PARTICIPANT STOICHIOMETRY r52 178
type: Stoichiometry
physical entity: Complex (HIF-1_beta/HIF-1_alpha/ P300)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r52 175
type: Stoichiometry
physical entity: HIF-1alpha
stoichiometric coefficient: 1.0

uniprot Q9WUA6 88
type: UnificationXref
id: Q9WUA6
db: uniprot

uniprot E2RJX4 60
type: UnificationXref
id: E2RJX4
db: uniprot

Thioredoxin
type: ProteinReference
xref: uniprot P08629 132
xref: PTHR10438:SF18
organism: Gallus gallus

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 121

uniprot F6QE96 66
type: UnificationXref
id: F6QE96
db: uniprot

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

CREB-binding protein isoform a
type: ProteinReference
xref: uniprot F6RRA8 10
xref: PTHR13808:SF34
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r26 172
type: Stoichiometry
physical entity: AKT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r26 171
type: Stoichiometry
physical entity: AKT
stoichiometric coefficient: 1.0

Aryl hydrocarbon receptor nuclear translocator
type: ProteinReference
xref: uniprot H2R3D7 90
xref: PTHR23042:SF50
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r25 174
type: Stoichiometry
physical entity: HIF-1alpha
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase Tor
type: ProteinReference
xref: PTHR11139:SF9
xref: uniprot Q9VK45 46
organism: Drosophila melanogaster

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6XP81 70
xref: PTHR24356:SF171
organism: Xenopus tropicalis

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 82

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 24

Uncharacterized protein
type: ProteinReference
xref: uniprot J9P204 91
xref: PTHR23042:SF50
organism: Canis lupus familiaris

EGLN3 protein
type: ProteinReference
xref: PTHR12907:SF5
xref: uniprot A7MBA0 95
organism: Bos taurus

ncbitaxon 224308 137
type: UnificationXref
id: 224308
db: ncbitaxon

ncbitaxon 7227 47
type: UnificationXref
id: 7227
db: ncbitaxon

ncbitaxon 214684 44
type: UnificationXref
id: 214684
db: ncbitaxon

Complex (HIF-1_alpha/OH)
type: Complex
component stoichiometry: HIF 1alpha s4 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: OH s7 sa4 STOICHIOMETRY ID COMPLEX
component: HIF-1alpha
component: OH
feature: COMPLEX BINDING FEATURE s53 a64 163
feature: COMPLEX BINDING FEATURE s53 a64 161
cellular location: cytosol

ncbitaxon 9913 5
type: UnificationXref
id: 9913
db: ncbitaxon

VHL
type: Protein
entity reference: VHL
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Thioredoxin
type: ProteinReference
xref: uniprot Q9NGZ1 151
xref: PTHR46115:SF1
organism: Anopheles gambiae

REF-1
type: Protein
feature: ACTIVE 48
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot O54857 115
type: UnificationXref
id: O54857
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__HRE_gene_low_transcription-RIGHT__HRE_gene_low_transcription-_re21
control type: ACTIVATION
controller: Complex (HIF-1_beta/HIF-1_alpha/ P300)

uniprot A0JND0 49
type: UnificationXref
id: A0JND0
db: uniprot

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P31751 77
type: UnificationXref
id: P31751
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HIF_1alpha-RIGHT__HIF_1alpha-_r25
controller: TOR

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 20

HRE gene/high transcription
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

uniprot Q8TL30 148
type: UnificationXref
id: Q8TL30
db: uniprot

PARTICIPANT STOICHIOMETRY r45 194
type: Stoichiometry
physical entity: Thioredoxin
stoichiometric coefficient: 1.0

HIF 1alpha s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: HIF-1alpha
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 195
type: Stoichiometry
physical entity: Thioredoxin
stoichiometric coefficient: 1.0

IDA
type: EvidenceCodeVocabulary

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

ncbitaxon 7955 62
type: UnificationXref
id: 7955
db: ncbitaxon

INHIBITION
type: RelationshipTypeVocabulary

CREB-binding protein
type: ProteinReference
xref: uniprot P45481 16
xref: PTHR13808:SF34
organism: Mus musculus

Serine/threonine-protein kinase akt-1
type: ProteinReference
xref: uniprot Q17941 80
xref: PTHR24356:SF333
organism: Caenorhabditis elegans

PTHR13808:SF34
type: RelationshipXref
id: PTHR13808:SF34
db: PANTHER Family
relationship type: By Homology

uniprot Q9LT75 122
type: UnificationXref
id: Q9LT75
db: uniprot

OH s7 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: OH
stoichiometric coefficient: 1.0

uniprot Q61221 56
type: UnificationXref
id: Q61221
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

uniprot F1Q4F8 65
type: UnificationXref
id: F1Q4F8
db: uniprot

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: uniprot E1BFB4 27
xref: PTHR11139:SF9
organism: Bos taurus

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot F1NT98 112
xref: PTHR12305:SF81
organism: Gallus gallus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF200
xref: uniprot G3X7B5 73
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F1MYJ4 63
organism: Bos taurus

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot O54857 115
xref: PTHR12305:SF81
organism: Rattus norvegicus

Thioredoxin
type: ProteinReference
xref: PTHR10438:SF18
xref: uniprot P10599 133
organism: Homo sapiens

HRE gene/low transcription
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_TOR-RIGHT__ADP-_TOR-_r22
controller: AKT

PTHR46115:SF1
type: RelationshipXref
id: PTHR46115:SF1
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot Q8T9S7 120
organism: Dictyostelium discoideum

Thioredoxin
type: ProteinReference
xref: uniprot O67747 129
organism: Aquifex aeolicus

TRANSPORT_LEFT__Thioredoxin-RIGHT__Thioredoxin-_r45
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 195
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 194
left: Thioredoxin
interaction type: TRANSPORT
right: Thioredoxin

uniprot Q9RYY9 152
type: UnificationXref
id: Q9RYY9
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2RJX4 60
xref: PTHR24356:SF171
organism: Canis lupus familiaris

uniprot F1MD32 4
type: UnificationXref
id: F1MD32
db: uniprot

STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_r26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 172
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 171
left: AKT
interaction type: STATE_TRANSITION
right: AKT

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F1Q4F8 65
organism: Canis lupus familiaris

STATE_TRANSITION_LEFT__OH-_HIF_1alpha-RIGHT__Complex__OH_HIF_1_alpha_-_r31
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 202
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 201
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 200
left: HIF-1alpha
left: OH
interaction type: STATE_TRANSITION
right: Complex (OH/HIF-1_alpha)

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

uniprot F7BR59 97
type: UnificationXref
id: F7BR59
db: uniprot

ncbitaxon 3702 123
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot Q6JHU9 19
type: UnificationXref
id: Q6JHU9
db: uniprot

uniprot F6RCU6 69
type: UnificationXref
id: F6RCU6
db: uniprot

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot Q60823 83
type: UnificationXref
id: Q60823
db: uniprot

EGLN3 isoform 1
type: ProteinReference
xref: uniprot H2Q856 101
xref: PTHR12907:SF5
organism: Pan troglodytes

REF-1
type: Protein
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P60483 117
type: UnificationXref
id: P60483
db: uniprot

uniprot F7H2R2 127
type: UnificationXref
id: F7H2R2
db: uniprot

PTHR10438:SF423
type: RelationshipXref
id: PTHR10438:SF423
db: PANTHER Family
relationship type: By Homology

uniprot G3X7B5 73
type: UnificationXref
id: G3X7B5
db: uniprot

ncbitaxon 188937 149
type: UnificationXref
id: 188937
db: ncbitaxon

uniprot P31749 75
type: UnificationXref
id: P31749
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 139

TOR
type: Protein
entity reference: TOR
feature: TOR s32 a40 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot G2HG38 100
type: UnificationXref
id: G2HG38
db: uniprot

ACTIVE 48
type: EntityFeature
comment: Active state