uniprot Q9UQM7 582
type: UnificationXref
id: Q9UQM7
db: uniprot

uniprot O08586 591
type: UnificationXref
id: O08586
db: uniprot

Rac family small GTPase 3
type: ProteinReference
xref: uniprot F6THF0 200
organism: Monodelphis domestica

uniprot P11835 650
type: UnificationXref
id: P11835
db: uniprot

uniprot Q8VDD5 1344
type: UnificationXref
id: Q8VDD5
db: uniprot

Myosin-7B
type: ProteinReference
xref: PTHR45615:SF29
xref: uniprot A2AQP0 1259
organism: Mus musculus

uniprot P10676 1317
type: UnificationXref
id: P10676
db: uniprot

uniprot C3ZHN2 940
type: UnificationXref
id: C3ZHN2
db: uniprot

uniprot Q21754 1503
type: UnificationXref
id: Q21754
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A452DI16 512
organism: Bos taurus

PTHR24351:SF200
type: RelationshipXref
id: PTHR24351:SF200
db: PANTHER Family
relationship type: By Homology

G protein subunit alpha i1
type: ProteinReference
xref: uniprot F1P977 87
organism: Canis lupus familiaris

uniprot H2Q4C6 452
type: UnificationXref
id: H2Q4C6
db: uniprot

uniprot P38040 351
type: UnificationXref
id: P38040
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot A4IFL6 309
organism: Bos taurus

uniprot F7GAP5 1372
type: UnificationXref
id: F7GAP5
db: uniprot

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot Q08462 479
xref: PTHR45627:SF6
organism: Homo sapiens

uniprot Q64303 421
type: UnificationXref
id: Q64303
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q7ZWH4 1628
xref: PTHR12644:SF1
organism: Danio rerio

Mus musculus
type: BioSource
xref: ncbitaxon 10090 29

Myosin heavy chain 9
type: ProteinReference
xref: uniprot F6RH86 1289
xref: PTHR45615:SF16
organism: Ornithorhynchus anatinus

uniprot P05412 438
type: UnificationXref
id: P05412
db: uniprot

uniprot F1P977 87
type: UnificationXref
id: F1P977
db: uniprot

uniprot P48736 1384
type: UnificationXref
id: P48736
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot Q5RKP9 43
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F1PXS7 267
organism: Canis lupus familiaris

Platelet factor 4
type: ProteinReference
xref: uniprot P02776 828
xref: PTHR10179:SF43
organism: Homo sapiens

C-X-C motif chemokine 10
type: ProteinReference
xref: uniprot P02778 829
xref: PTHR10179:SF47
organism: Homo sapiens

uniprot P30882 844
type: UnificationXref
id: P30882
db: uniprot

uniprot H2Q943 982
type: UnificationXref
id: H2Q943
db: uniprot

Actin related protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A8BV70 903
organism: Giardia intestinalis

STATE_TRANSITION_LEFT__Complex__CHKR_CHK_-RIGHT__Complex__CHKR_CHK_-_re70
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re70 1858
participant stoichiometry: PARTICIPANT STOICHIOMETRY re70 1859
left: Complex (CHKR/CHK)
interaction type: STATE_TRANSITION
right: Complex (CHKR/CHK)

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BD45 1297
xref: PTHR45615:SF2
organism: Monodelphis domestica

uniprot A2FA04 891
type: UnificationXref
id: A2FA04
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F1Q118 597
organism: Canis lupus familiaris

Cytoplasmatic actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot E9FXV8 948
organism: Daphnia pulex

uniprot K7CBH8 1134
type: UnificationXref
id: K7CBH8
db: uniprot

uniprot F1N2G0 1276
type: UnificationXref
id: F1N2G0
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 112

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: PTHR12058:SF0
xref: uniprot P85970 1608
organism: Rattus norvegicus

uniprot E1BX17 1646
type: UnificationXref
id: E1BX17
db: uniprot

uniprot E2RT75 1449
type: UnificationXref
id: E2RT75
db: uniprot

uniprot F1NAB9 1198
type: UnificationXref
id: F1NAB9
db: uniprot

uniprot P29994 497
type: UnificationXref
id: P29994
db: uniprot

NRAS protein
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot A5D7R9 1395
organism: Bos taurus

uniprot Q99323 1347
type: UnificationXref
id: Q99323
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r32
controller: GEF

PTHR10218:SF328
type: RelationshipXref
id: PTHR10218:SF328
db: PANTHER Family
relationship type: By Homology

uniprot P12370 1162
type: UnificationXref
id: P12370
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot F7CTP1 330
organism: Macaca mulatta

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot Q9Z1L0 1392
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r76
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 1815
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 1816
left: MEK
interaction type: STATE_TRANSITION
right: MEK

Actin
type: ProteinReference
xref: PTHR11937:SF389
xref: uniprot Q6XNL8 1070
organism: Danio rerio

uniprot P27479 136
type: UnificationXref
id: P27479
db: uniprot

uniprot P78774 1607
type: UnificationXref
id: P78774
db: uniprot

uniprot Q04790 1243
type: UnificationXref
id: Q04790
db: uniprot

uniprot A0A2I3RHK4 1251
type: UnificationXref
id: A0A2I3RHK4
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A0A2I3RV12 1436
organism: Pan troglodytes

PTHR24356:SF333
type: RelationshipXref
id: PTHR24356:SF333
db: PANTHER Family
relationship type: By Homology

uniprot Q65XH8 1060
type: UnificationXref
id: Q65XH8
db: uniprot

uniprot Q91Z83 1346
type: UnificationXref
id: Q91Z83
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AP_1-RIGHT__AP_1-_r78
controller: MAPK

STATE_TRANSITION_LEFT__CaMK-RIGHT__CaMK-_r26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 1884
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 1885
left: CaMK
interaction type: STATE_TRANSITION
right: CaMK

uniprot P52631 160
type: UnificationXref
id: P52631
db: uniprot

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot Q6P378 1066
organism: Xenopus tropicalis

uniprot A0A2I3RVP2 1437
type: UnificationXref
id: A0A2I3RVP2
db: uniprot

G protein subunit alpha 14
type: ProteinReference
xref: uniprot A0A2I3TRC4 9
organism: Pan troglodytes

Inhibitor of nuclear factor kappa B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot E2RKR0 1416
organism: Canis lupus familiaris

Actin-7
type: ProteinReference
xref: uniprot P0C540 994
xref: PTHR11937:SF408
organism: Oryza sativa

uniprot F6Y1K4 807
type: UnificationXref
id: F6Y1K4
db: uniprot

C-C motif chemokine receptor 1
type: ProteinReference
xref: PTHR10489:SF711
xref: uniprot Q9JLY8 776
organism: Rattus norvegicus

PTHR46256:SF1
type: RelationshipXref
id: PTHR46256:SF1
db: PANTHER Family
relationship type: By Homology

fMet-Leu-Phe receptor
type: ProteinReference
xref: PTHR24225:SF15
xref: uniprot P33766 720
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q9QW07 1529
organism: Rattus norvegicus

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot Q05933 1610
xref: PTHR12391:SF0
organism: Saccharomyces cerevisiae

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot E7EXT6 53
organism: Danio rerio

uniprot D9ZDE4 668
type: UnificationXref
id: D9ZDE4
db: uniprot

uniprot F6UA54 966
type: UnificationXref
id: F6UA54
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F7DUD6 1368
organism: Ornithorhynchus anatinus

uniprot P51678 735
type: UnificationXref
id: P51678
db: uniprot

PTHR46256:SF4
type: RelationshipXref
id: PTHR46256:SF4
db: PANTHER Family
relationship type: By Homology

uniprot E2RPW6 544
type: UnificationXref
id: E2RPW6
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot F7CU42 403
organism: Monodelphis domestica

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6QP11 58
organism: Monodelphis domestica

IP3R
type: Protein
entity reference: IP3R
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

PTHR45945:SF2
type: RelationshipXref
id: PTHR45945:SF2
db: PANTHER Family
relationship type: By Homology

uniprot E1BI98 1193
type: UnificationXref
id: E1BI98
db: uniprot

A-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot E2RL20 514
organism: Canis lupus familiaris

Actin-like protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot O24426 987
organism: Chlamydomonas reinhardtii

uniprot F1N8W8 396
type: UnificationXref
id: F1N8W8
db: uniprot

uniprot P26769 473
type: UnificationXref
id: P26769
db: uniprot

uniprot Q8TCU6 1547
type: UnificationXref
id: Q8TCU6
db: uniprot

Myosin-4
type: ProteinReference
xref: uniprot Q9Y623 1353
xref: PTHR45615:SF2
organism: Homo sapiens

Protein-tyrosine kinase 2-beta
type: ProteinReference
xref: uniprot Q9QVP9 634
xref: PTHR24418:SF94
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R3L5 1091
organism: Macaca mulatta

Suppressor of cytokine signaling 6
type: ProteinReference
xref: PTHR10155:SF17
xref: uniprot Q9JLY0 1688
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A8XTZ1 1446
organism: Caenorhabditis briggsae

Rho-related protein racA
type: ProteinReference
xref: uniprot P34147 220
organism: Dictyostelium discoideum

Rho-related protein racB
type: ProteinReference
xref: uniprot P34148 221
organism: Dictyostelium discoideum

Rho-related protein rac1B
type: ProteinReference
xref: uniprot P34145 218
organism: Dictyostelium discoideum

Uncharacterized protein
type: ProteinReference
xref: PTHR24169:SF21
xref: uniprot F7GVU6 1100
organism: Macaca mulatta

Rho-related protein rac1C
type: ProteinReference
xref: uniprot P34146 219
organism: Dictyostelium discoideum

uniprot Q5R1X3 1058
type: UnificationXref
id: Q5R1X3
db: uniprot

Rho-related protein rac1A
type: ProteinReference
xref: uniprot P34144 216
organism: Dictyostelium discoideum

SOCS5 isoform 1
type: ProteinReference
xref: uniprot H2RII6 1678
xref: PTHR10155:SF15
organism: Pan troglodytes

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Complex__CHKR_CHK_-RIGHT__Complex__CHKR_CHK_-_re70
control type: ACTIVATION
controller: Arrestin

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PYK2-RIGHT__PYK2-_r18
controller: Complex (Galphai/GTP)

uniprot Q5F3B5 41
type: UnificationXref
id: Q5F3B5
db: uniprot

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b
type: ProteinReference
xref: uniprot A0A0G2JTY4 603
xref: PTHR12533:SF6
organism: Rattus norvegicus

Arachidonic acid
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A3Q1MKC7 556
type: UnificationXref
id: A0A3Q1MKC7
db: uniprot

uniprot P51817 1169
type: UnificationXref
id: P51817
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot Q21754 1503
organism: Caenorhabditis elegans

ALOX5AP isoform 2
type: ProteinReference
xref: PTHR10250:SF2
xref: uniprot H2Q7D6 130
organism: Pan troglodytes

uniprot P63035 1545
type: UnificationXref
id: P63035
db: uniprot

uniprot P68139 1038
type: UnificationXref
id: P68139
db: uniprot

Calcium/calmodulin-dependent protein kinase type II subunit delta
type: ProteinReference
xref: PTHR24347:SF365
xref: uniprot Q2HJF7 575
organism: Bos taurus

uniprot F6T6T3 433
type: UnificationXref
id: F6T6T3
db: uniprot

uniprot P28652 571
type: UnificationXref
id: P28652
db: uniprot

uniprot P22126 1407
type: UnificationXref
id: P22126
db: uniprot

PARTICIPANT STOICHIOMETRY r38 1834
type: Stoichiometry
physical entity: Myosin
stoichiometric coefficient: 1.0

ncbitaxon 39947 287
type: UnificationXref
id: 39947
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r38 1835
type: Stoichiometry
physical entity: Myosin
stoichiometric coefficient: 1.0

Myosin light chain kinase 2, skeletal/cardiac muscle
type: ProteinReference
xref: PTHR24347:SF373
xref: uniprot P20689 1651
organism: Rattus norvegicus

uniprot Q9Z126 883
type: UnificationXref
id: Q9Z126
db: uniprot

C-C motif chemokine 4
type: ProteinReference
xref: uniprot P13236 836
organism: Homo sapiens

IkappaB
type: Protein
entity reference: IkappaB
feature: IkappaB s204 a296 rs2
feature: IkappaB s204 a296 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Interferon alpha/beta receptor 1
type: ProteinReference
xref: PTHR20859:SF54
xref: uniprot H9Z8H4 1239
organism: Macaca mulatta

uniprot F6R6B9 805
type: UnificationXref
id: F6R6B9
db: uniprot

C-C motif chemokine receptor 9
type: ProteinReference
xref: PTHR10489:SF664
xref: uniprot Q8CH33 770
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r31 1856
type: Stoichiometry
physical entity: Rho
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r31 1857
type: Stoichiometry
physical entity: Rho
stoichiometric coefficient: 1.0

uniprot A0A3Q1M0G8 383
type: UnificationXref
id: A0A3Q1M0G8
db: uniprot

PTHR46051:SF2
type: RelationshipXref
id: PTHR46051:SF2
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 4
type: ProteinReference
xref: PTHR24055:SF439
xref: uniprot Q39024 291
organism: Arabidopsis thaliana

CHKR
type: Protein
entity reference: CHKR
feature: COMPLEX PARTICIPANT BINDING FEATURE s207 sa159 1715
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot Q39027 293
xref: PTHR24055:SF401
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot Q39026 292
xref: PTHR24055:SF466
organism: Arabidopsis thaliana

MODULATION
type: RelationshipTypeVocabulary

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF378
xref: uniprot Q39021 288
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF391
xref: uniprot Q39023 290
organism: Arabidopsis thaliana

CaMK
type: ProteinReference
xref: P00847
standard name: Calcium/calModulin-dependent Kinase II
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.CaMK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Calcium/calModulin-dependent Kinase II Synonym: Synonym not specified Accession: P00847
member entity reference: Calcium/calmodulin-dependent serine protein kinase (MAGUK family)
member entity reference: Uncharacterized protein
member entity reference: Peripheral plasma membrane protein CASK
member entity reference: Calcium/calmodulin-dependent protein kinase type II subunit delta
member entity reference: CASK isoform 4
member entity reference: Calcium/calmodulin-dependent protein kinase type II subunit alpha
member entity reference: Calcium/calmodulin-dependent protein kinase type II subunit gamma
member entity reference: Calcium/calmodulin-dependent protein kinase type II delta 1 chain
member entity reference: Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
member entity reference: Calcium/calmodulin dependent protein kinase II gamma
member entity reference: Calcium/calmodulin-dependent protein kinase type II subunit beta
member entity reference: Calcium/calmodulin-dependent protein kinase type II alpha chain
member entity reference: Calcium/calmodulin-dependent protein kinase type II
member entity reference: CAMK2A isoform 3
member entity reference: Calcium/calmodulin-dependent protein kinase type II delta chain
member entity reference: Calcium/calmodulin dependent protein kinase II delta
member entity reference: Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta

Mitogen-activated protein kinase 2
type: ProteinReference
xref: PTHR24055:SF196
xref: uniprot Q39022 289
organism: Arabidopsis thaliana

Complex (Cytokine receptor/IL2/ STAT/JAK/ JAK)
type: Complex
component stoichiometry: IL2 s100 sa45 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cytokine receptor s99 sa44 STOICHIOMETRY ID COMPLEX
component stoichiometry: STAT s104 sa46 STOICHIOMETRY ID COMPLEX
component stoichiometry: JAK s105 sa47 STOICHIOMETRY ID COMPLEX
component: Cytokine receptor
component: IL2
component: JAK
component: STAT
feature: COMPLEX BINDING FEATURE s196 a287 1778
feature: COMPLEX BINDING FEATURE s196 a287 1776
feature: COMPLEX BINDING FEATURE s196 a287 1774
feature: COMPLEX BINDING FEATURE s196 a287 1780
cellular location: cytoplasm

GRB2-related adapter protein
type: ProteinReference
xref: uniprot Q13588 584
xref: PTHR46037:SF2
organism: Homo sapiens

uniprot F7D2P3 561
type: UnificationXref
id: F7D2P3
db: uniprot

00696
type: UnificationXref
id: MOD:00696
db: mod

uniprot P34145 218
type: UnificationXref
id: P34145
db: uniprot

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
type: ProteinReference
xref: PTHR24353:SF135
xref: uniprot Q6DBV8 1178
organism: Danio rerio

uniprot E2R6T4 430
type: UnificationXref
id: E2R6T4
db: uniprot

PTHR10336:SF106
type: RelationshipXref
id: PTHR10336:SF106
db: PANTHER Family
relationship type: By Homology

uniprot Q6LC82 249
type: UnificationXref
id: Q6LC82
db: uniprot

PTHR11339:SF361
type: RelationshipXref
id: PTHR11339:SF361
db: PANTHER Family
relationship type: By Homology

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF1
xref: uniprot Q9JM76 1635
organism: Mus musculus

Nuclear factor of activated T-cells, cytoplasmic 3
type: ProteinReference
xref: uniprot Q12968 623
xref: PTHR12533:SF6
organism: Homo sapiens

TRANSCRIPTION_LEFT__Pro_inflammatory_anti_apoptotic_genes-RIGHT__pro_inflammatory_anti_apoptotic_genes-_re71
type: TemplateReaction
product: pro-inflammatory anti-apoptotic genes
xref: TRANSCRIPTION
participant: pro-inflammatory anti-apoptotic genes
participant: Pro-inflammatory anti-apoptotic genes
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot E1C795 311
type: UnificationXref
id: E1C795
db: uniprot

PARTICIPANT STOICHIOMETRY r8 1786
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 1787
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

uniprot O24426 987
type: UnificationXref
id: O24426
db: uniprot

Physcomitrella patens
type: BioSource
xref: ncbitaxon 3218 913

Putative actin-9
type: ProteinReference
xref: PTHR11937:SF483
xref: uniprot P93738 1043
organism: Arabidopsis thaliana

uniprot H2QZN8 342
type: UnificationXref
id: H2QZN8
db: uniprot

uniprot H2PZK9 95
type: UnificationXref
id: H2PZK9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKCzeta-RIGHT__PKCzeta-_r40
controller: Rho

uniprot O15143 1587
type: UnificationXref
id: O15143
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XD59 1199
xref: PTHR24020:SF29
organism: Macaca mulatta

PTHR48015:SF30
type: RelationshipXref
id: PTHR48015:SF30
db: PANTHER Family
relationship type: By Homology

uniprot H9H490 821
type: UnificationXref
id: H9H490
db: uniprot

uniprot F7CXD0 331
type: UnificationXref
id: F7CXD0
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot P50150 353
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot P50151 354
organism: Homo sapiens

uniprot P18870 446
type: UnificationXref
id: P18870
db: uniprot

uniprot Q04683 757
type: UnificationXref
id: Q04683
db: uniprot

uniprot P38328 1601
type: UnificationXref
id: P38328
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot P50153 355
organism: Mus musculus

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: uniprot P50148 38
organism: Homo sapiens

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot P50146 105
organism: Gallus gallus

Rho family GTPase
type: ProteinReference
xref: uniprot C4M8K6 193
organism: Entamoeba histolytica

uniprot P79243 755
type: UnificationXref
id: P79243
db: uniprot

uniprot Q076A6 1331
type: UnificationXref
id: Q076A6
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__PYK2-RIGHT__PYK2-_r18
control type: ACTIVATION
controller: Ca2+

Actin-related protein 2/3 complex subunit 1
type: ProteinReference
xref: PTHR10709:SF2
xref: uniprot P38328 1601
organism: Saccharomyces cerevisiae

PTHR24230:SF8
type: RelationshipXref
id: PTHR24230:SF8
db: PANTHER Family
relationship type: By Homology

Myosin-10
type: ProteinReference
xref: PTHR45615:SF24
xref: uniprot Q9JLT0 1350
organism: Rattus norvegicus

uniprot Q4KM68 585
type: UnificationXref
id: Q4KM68
db: uniprot

uniprot P32383 1494
type: UnificationXref
id: P32383
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot H2QJ75 1473
organism: Pan troglodytes

uniprot F7DPD5 562
type: UnificationXref
id: F7DPD5
db: uniprot

uniprot F1QUN8 955
type: UnificationXref
id: F1QUN8
db: uniprot

PTHR20859:SF54
type: RelationshipXref
id: PTHR20859:SF54
db: PANTHER Family
relationship type: By Homology

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F7D5G3 1468
organism: Ornithorhynchus anatinus

uniprot P10824 103
type: UnificationXref
id: P10824
db: uniprot

Serine/threonine-protein kinase akt-2
type: ProteinReference
xref: uniprot Q9XTG7 79
xref: PTHR24356:SF333
organism: Caenorhabditis elegans

uniprot O00421 694
type: UnificationXref
id: O00421
db: uniprot

PTHR20859:SF50
type: RelationshipXref
id: PTHR20859:SF50
db: PANTHER Family
relationship type: By Homology

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot F7G800 405
organism: Monodelphis domestica

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P27791 1166
xref: PTHR24353:SF82
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot A0A3Q2U0G2 1442
xref: PTHR10336:SF106
organism: Gallus gallus

uniprot Q944C1 1522
type: UnificationXref
id: Q944C1
db: uniprot

NF-kappaB transcription factor p65 subunit
type: ProteinReference
xref: uniprot A1XG22 1094
organism: Bos taurus

Growth factor receptor-bound protein 2a
type: ProteinReference
xref: PTHR46037:SF4
xref: uniprot Q5RKN6 586
organism: Danio rerio

PTHR20859:SF46
type: RelationshipXref
id: PTHR20859:SF46
db: PANTHER Family
relationship type: By Homology

ncbitaxon 321614 114
type: UnificationXref
id: 321614
db: ncbitaxon

PTHR10155:SF5
type: RelationshipXref
id: PTHR10155:SF5
db: PANTHER Family
relationship type: By Homology

PTHR10155:SF9
type: RelationshipXref
id: PTHR10155:SF9
db: PANTHER Family
relationship type: By Homology

uniprot E2RE16 392
type: UnificationXref
id: E2RE16
db: uniprot

uniprot Q04207 1108
type: UnificationXref
id: Q04207
db: uniprot

uniprot P02563 1313
type: UnificationXref
id: P02563
db: uniprot

uniprot F1N1Q7 1537
type: UnificationXref
id: F1N1Q7
db: uniprot

C-C motif chemokine receptor like 2
type: ProteinReference
xref: uniprot H2R3S4 688
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F7AZP2 1674
xref: PTHR10155:SF15
organism: Monodelphis domestica

Serine/threonine-protein kinase PAK 5
type: ProteinReference
xref: uniprot Q8C015 424
organism: Mus musculus

MEK
type: Protein
entity reference: MEK
feature: MEK s198 a240 rs1
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HPR8 1232
xref: PTHR10337:SF2
organism: Macaca mulatta

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: uniprot P19174 1492
xref: PTHR10336:SF173
organism: Homo sapiens

Collagen alpha-1(XII) chain
type: ProteinReference
xref: PTHR24020:SF17
xref: uniprot Q99715 1224
organism: Homo sapiens

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot Q6RUV5 250
organism: Rattus norvegicus

uniprot A6QPA6 1262
type: UnificationXref
id: A6QPA6
db: uniprot

uniprot F7E823 269
type: UnificationXref
id: F7E823
db: uniprot

Arrestin
type: Protein
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR11771:SF4
xref: uniprot F7GAZ2 129
organism: Macaca mulatta

uniprot A9TYG6 916
type: UnificationXref
id: A9TYG6
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot P13217 1490
xref: PTHR10336:SF106
organism: Drosophila melanogaster

ncbitaxon 418459 946
type: UnificationXref
id: 418459
db: ncbitaxon

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot A0A0G2K5T3 1355
xref: PTHR10048:SF107
organism: Rattus norvegicus

uniprot F6TAH0 1462
type: UnificationXref
id: F6TAH0
db: uniprot

Non-muscle actin 6.2
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot B3S5E4 924
organism: Trichoplax adhaerens

Myosin, heavy chain 9, non-muscle
type: ProteinReference
xref: uniprot F6YTJ1 1294
xref: PTHR45615:SF16
organism: Xenopus tropicalis

uniprot Q0U5H3 238
type: UnificationXref
id: Q0U5H3
db: uniprot

uniprot F1PCU1 1098
type: UnificationXref
id: F1PCU1
db: uniprot

uniprot P51671 851
type: UnificationXref
id: P51671
db: uniprot

STAT
type: ProteinReference
xref: P00832
standard name: Signal transducers and activaotrs of transcription
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.STAT
comment: ENTITY_REFERENCE_NOTES=Long Name: Signal transducers and activaotrs of transcription Synonym: Synonym not specified Accession: P00832
member entity reference: Signal transducer and transcription activator 6
member entity reference: Signal transducer and activator of transcription 3
member entity reference: Signal transducer and activator of transcription
member entity reference: Signal transducer and activator of transcription 1

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P04897 97
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7EI48 271
xref: PTHR24055:SF393
organism: Monodelphis domestica

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 786
xref: uniprot A4IFJ5 785
xref: PTHR10728:SF13
organism: Bos taurus

uniprot J9JHK9 1480
type: UnificationXref
id: J9JHK9
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P04899 98
organism: Homo sapiens

uniprot P79189 751
type: UnificationXref
id: P79189
db: uniprot

Ca2+
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=ION

Peripheral plasma membrane protein CASK
type: ProteinReference
xref: PTHR23122:SF40
xref: uniprot O14936 566
organism: Homo sapiens

C-C chemokine receptor type 7
type: ProteinReference
xref: PTHR10489:SF635
xref: uniprot P32248 718
organism: Homo sapiens

PTHR10179:SF42
type: RelationshipXref
id: PTHR10179:SF42
db: PANTHER Family
relationship type: By Homology

C-C motif chemokine
type: ProteinReference
xref: uniprot F6R6B9 805
xref: PTHR12015:SF94
organism: Macaca mulatta

uniprot F2Z4N7 958
type: UnificationXref
id: F2Z4N7
db: uniprot

Actin-57B
type: ProteinReference
xref: PTHR11937:SF397
xref: uniprot P53501 1012
organism: Drosophila melanogaster

uniprot O08556 696
type: UnificationXref
id: O08556
db: uniprot

JAK s105 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JAK
stoichiometric coefficient: 2.0

uniprot Q5ZKI0 577
type: UnificationXref
id: Q5ZKI0
db: uniprot

uniprot A4IFJ5 785
type: UnificationXref
id: A4IFJ5
db: uniprot

C-X-C chemokine receptor type 1
type: ProteinReference
xref: PTHR10489:SF916
xref: uniprot Q2YEG0 762
organism: Macaca mulatta

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot Q9V3Q6 1231
organism: Drosophila melanogaster

uniprot P84185 1041
type: UnificationXref
id: P84185
db: uniprot

uniprot A0A1D5RI29 1092
type: UnificationXref
id: A0A1D5RI29
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

uniprot Q7PWN2 1626
type: UnificationXref
id: Q7PWN2
db: uniprot

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 84

PTHR10179:SF38
type: RelationshipXref
id: PTHR10179:SF38
db: PANTHER Family
relationship type: By Homology

AGAP000018-PA
type: ProteinReference
xref: uniprot Q7QEJ7 1389
organism: Anopheles gambiae

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 519

uniprot Q9Z1B3 1532
type: UnificationXref
id: Q9Z1B3
db: uniprot

uniprot G5EB66 1150
type: UnificationXref
id: G5EB66
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q3SYX9 1617
xref: PTHR12644:SF1
organism: Bos taurus

uniprot F1PS03 1457
type: UnificationXref
id: F1PS03
db: uniprot

uniprot Q9NQU5 426
type: UnificationXref
id: Q9NQU5
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot Q3SZ98 370
organism: Bos taurus

Proto-oncogene vav
type: ProteinReference
xref: PTHR45818:SF2
xref: uniprot P27870 1543
organism: Mus musculus

uniprot F7GUL4 1676
type: UnificationXref
id: F7GUL4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q373 658
xref: PTHR10489:SF664
organism: Macaca mulatta

uniprot P34147 220
type: UnificationXref
id: P34147
db: uniprot

uniprot P25799 1104
type: UnificationXref
id: P25799
db: uniprot

PTHR10179:SF43
type: RelationshipXref
id: PTHR10179:SF43
db: PANTHER Family
relationship type: By Homology

uniprot O08773 171
type: UnificationXref
id: O08773
db: uniprot

uniprot A0A1D5R3L5 1091
type: UnificationXref
id: A0A1D5R3L5
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot F6THW2 16
organism: Xenopus tropicalis

PTHR10179:SF47
type: RelationshipXref
id: PTHR10179:SF47
db: PANTHER Family
relationship type: By Homology

uniprot Q8UUX0 77
type: UnificationXref
id: Q8UUX0
db: uniprot

uniprot H9ZA60 1479
type: UnificationXref
id: H9ZA60
db: uniprot

uniprot E2R9G5 313
type: UnificationXref
id: E2R9G5
db: uniprot

uniprot A4FUQ5 663
type: UnificationXref
id: A4FUQ5
db: uniprot

Ras-related protein R-Ras
type: ProteinReference
xref: uniprot D3Z8L7 1396
xref: PTHR24070:SF245
organism: Rattus norvegicus

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 7

Myosin-11
type: ProteinReference
xref: PTHR45615:SF23
xref: uniprot O08638 1312
organism: Mus musculus

uniprot H2QML4 1119
type: UnificationXref
id: H2QML4
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot Q9Z1B3 1532
organism: Mus musculus

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot O14920 1422
organism: Homo sapiens

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot F6T2E7 397
organism: Xenopus tropicalis

Regulator of G-protein signaling 13
type: ProteinReference
xref: PTHR10845:SF32
xref: uniprot O14921 172
organism: Homo sapiens

C-X-C motif chemokine 10
type: ProteinReference
xref: uniprot P48973 847
xref: PTHR10179:SF47
organism: Rattus norvegicus

uniprot P07829 992
type: UnificationXref
id: P07829
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P00517 1156
xref: PTHR24353:SF82
organism: Bos taurus

uniprot F6V001 468
type: UnificationXref
id: F6V001
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot F7GWI2 406
organism: Macaca mulatta

uniprot P68138 1037
type: UnificationXref
id: P68138
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 20

Actin, cytoskeletal 3B
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P18499 1002
organism: Strongylocentrotus purpuratus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ROCK-RIGHT__ROCK-_r35
controller: Rho

uniprot P43425 352
type: UnificationXref
id: P43425
db: uniprot

uniprot Q67G20 1061
type: UnificationXref
id: Q67G20
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7AE17 345
xref: PTHR13809:SF6
organism: Pan troglodytes

uniprot F1PJE5 317
type: UnificationXref
id: F1PJE5
db: uniprot

uniprot H2R4F5 617
type: UnificationXref
id: H2R4F5
db: uniprot

uniprot P15307 1103
type: UnificationXref
id: P15307
db: uniprot

uniprot F6TFK0 674
type: UnificationXref
id: F6TFK0
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_r9
controller: AC

uniprot F7DQK7 975
type: UnificationXref
id: F7DQK7
db: uniprot

uniprot A0A2I3TUE7 554
type: UnificationXref
id: A0A2I3TUE7
db: uniprot

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: uniprot O15530 148
xref: PTHR24356:SF163
organism: Homo sapiens

uniprot Q9R0Q6 1636
type: UnificationXref
id: Q9R0Q6
db: uniprot

PARTICIPANT STOICHIOMETRY r2 1810
type: Stoichiometry
physical entity: Complex (CHKR/Galphai/ q/GDP/ Gbetagamma)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 1811
type: Stoichiometry
physical entity: CHK
stoichiometric coefficient: 1.0

uniprot R4GKD1 380
type: UnificationXref
id: R4GKD1
db: uniprot

PTHR48015:SF22
type: RelationshipXref
id: PTHR48015:SF22
db: PANTHER Family
relationship type: By Homology

PTHR48015:SF20
type: RelationshipXref
id: PTHR48015:SF20
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r2 1812
type: Stoichiometry
physical entity: Complex (CHKR/CHK/ Galphai/q/ GDP/Gbetagamma)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF128
xref: uniprot H2RI77 1154
organism: Pan troglodytes

uniprot P35355 537
type: UnificationXref
id: P35355
db: uniprot

PTHR24070:SF245
type: RelationshipXref
id: PTHR24070:SF245
db: PANTHER Family
relationship type: By Homology

uniprot Q810W6 769
type: UnificationXref
id: Q810W6
db: uniprot

Myosin heavy chain 7B
type: ProteinReference
xref: PTHR45615:SF29
xref: uniprot A0A3Q1MS81 1258
organism: Bos taurus

Myosin heavy chain 14
type: ProteinReference
xref: uniprot F1MM57 1272
xref: PTHR45615:SF31
organism: Bos taurus

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot P59999 1606
organism: Mus musculus

uniprot P04897 97
type: UnificationXref
id: P04897
db: uniprot

uniprot Q9M1Z5 306
type: UnificationXref
id: Q9M1Z5
db: uniprot

PTHR10728:SF13
type: RelationshipXref
id: PTHR10728:SF13
db: PANTHER Family
relationship type: By Homology

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot P59998 1605
organism: Homo sapiens

uniprot F1PL99 1455
type: UnificationXref
id: F1PL99
db: uniprot

ncbitaxon 237561 212
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot Q10N20 286
type: UnificationXref
id: Q10N20
db: uniprot

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot O08648 1230
organism: Mus musculus

uniprot P13217 1490
type: UnificationXref
id: P13217
db: uniprot

Rac
type: Protein
entity reference: Rac
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Myosin heavy chain 7B
type: ProteinReference
xref: PTHR45615:SF29
xref: uniprot B6RK61 1265
organism: Rattus norvegicus

Actin-3
type: ProteinReference
xref: PTHR11937:SF411
xref: uniprot Q10AZ4 1045
organism: Oryza sativa

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Pro_inflammatory_genes-RIGHT__pro_inflammatory_genes-_re72
control type: ACTIVATION
controller: STAT

uniprot Q02956 123
type: UnificationXref
id: Q02956
db: uniprot

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: uniprot P38408 36
organism: Bos taurus

uniprot P70335 1691
type: UnificationXref
id: P70335
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot H9ERR5 1477
organism: Macaca mulatta

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot P38409 37
organism: Bos taurus

Cytokine receptor
type: ProteinReference
xref: P00866
comment: ENTITY_REFERENCE_NOTES=Long Name: Cytokine receptor Synonym: Synonym not specified Accession: P00866
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.RECEPTOR.Cytokine_br_receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Ifngr2 protein
member entity reference: Interleukin-10 receptor subunit beta
member entity reference: Interferon alpha/beta receptor 1
member entity reference: Interferon gamma receptor 1
member entity reference: IFNAR1 isoform 2

Uncharacterized protein
type: ProteinReference
xref: PTHR46256:SF4
xref: uniprot F6VF32 1291
organism: Macaca mulatta

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
type: ProteinReference
xref: uniprot Q86YW0 1515
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r74 1821
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r74 1822
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
type: ProteinReference
xref: uniprot P40977 1495
organism: Schizosaccharomyces pombe

uniprot F6TFY2 320
type: UnificationXref
id: F6TFY2
db: uniprot

uniprot H2QAS6 1133
type: UnificationXref
id: H2QAS6
db: uniprot

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 508
evidence: Evidence 507
evidence: Evidence 506
evidence: Evidence 509
xref: PTHR44329:SF22
xref: uniprot A0A2I3THL4 510
organism: Pan troglodytes

uniprot Q8RYC2 1081
type: UnificationXref
id: Q8RYC2
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot A0A2I3T8F7 1439
xref: PTHR10336:SF11
organism: Pan troglodytes

uniprot F7CIV4 973
type: UnificationXref
id: F7CIV4
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot A0A3Q1NH21 48
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7GAP5 1372
organism: Ornithorhynchus anatinus

PTHR10728:SF32
type: RelationshipXref
id: PTHR10728:SF32
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot Q99JE6 1523
organism: Rattus norvegicus

C-C motif chemokine
type: ProteinReference
xref: PTHR12015:SF102
xref: uniprot Q5I0L5 867
organism: Rattus norvegicus

uniprot P78711 1039
type: UnificationXref
id: P78711
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MLCK-RIGHT__MLCK-_r34
controller: ROCK

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cell Adhesion Cell Shape Change Chemotaxis Degranulation
controller: SrcPTK

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot Q9UK08 379
xref: PTHR13809:SF19
organism: Homo sapiens

uniprot B2WUP2 1667
type: UnificationXref
id: B2WUP2
db: uniprot

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot P29992 32
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot P29995 498
xref: PTHR13715:SF53
organism: Rattus norvegicus

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot P29994 497
xref: PTHR13715:SF52
organism: Rattus norvegicus

uniprot H2QCA0 1309
type: UnificationXref
id: H2QCA0
db: uniprot

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot F6SHC1 1418
organism: Macaca mulatta

uniprot P27791 1166
type: UnificationXref
id: P27791
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: uniprot O00329 1377
xref: PTHR10048:SF35
organism: Homo sapiens

G protein subunit alpha q
type: ProteinReference
xref: uniprot K6ZCJ5 23
organism: Pan troglodytes

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: PTHR12058:SF0
xref: uniprot Q9VIM5 1638
organism: Drosophila melanogaster

uniprot A0A3Q2U4X3 49
type: UnificationXref
id: A0A3Q2U4X3
db: uniprot

C-C chemokine receptor type 1
type: ProteinReference
xref: uniprot P32246 717
xref: PTHR10489:SF711
organism: Homo sapiens

uniprot P34148 221
type: UnificationXref
id: P34148
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1MLS3 1452
organism: Bos taurus

C-C motif chemokine 12
type: ProteinReference
xref: uniprot Q62401 869
organism: Mus musculus

Leukotriene B4 receptor 2
type: ProteinReference
xref: uniprot Q924U0 772
xref: PTHR24230:SF8
organism: Rattus norvegicus

Phosphoinositide phospholipase C 1
type: ProteinReference
xref: uniprot Q39032 1505
organism: Arabidopsis thaliana

Phosphoinositide phospholipase C 2
type: ProteinReference
xref: uniprot Q39033 1506
organism: Arabidopsis thaliana

GEF
type: ProteinReference
xref: P00875
standard name: Guanine nucleotide exchange factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.GEF
comment: ENTITY_REFERENCE_NOTES=Long Name: Guanine nucleotide exchange factor Synonym: GEF Accession: P00875
member entity reference: Uncharacterized protein
member entity reference: Proto-oncogene vav
member entity reference: Cytohesin-2
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
member entity reference: Vav guanine nucleotide exchange factor 1
member entity reference: Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
member entity reference: Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
member entity reference: Cytohesin 2
member entity reference: VAV1 isoform 2

uniprot F6XP81 61
type: UnificationXref
id: F6XP81
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF23
xref: uniprot F6R0F5 1288
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r27
controller: Gbetagamma

uniprot F1MP16 670
type: UnificationXref
id: F1MP16
db: uniprot

uniprot H2QVX8 631
type: UnificationXref
id: H2QVX8
db: uniprot

uniprot A7SEB1 902
type: UnificationXref
id: A7SEB1
db: uniprot

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 260

uniprot F1P354 1453
type: UnificationXref
id: F1P354
db: uniprot

uniprot F6RYL1 432
type: UnificationXref
id: F6RYL1
db: uniprot

uniprot H2QPN6 814
type: UnificationXref
id: H2QPN6
db: uniprot

uniprot A0A3Q1MSP9 119
type: UnificationXref
id: A0A3Q1MSP9
db: uniprot

CHK
type: Protein
entity reference: CHK
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa6 1725
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A0D1C4Y4 259
xref: PTHR24055:SF158
organism: Ustilago maydis

Integrin alpha-2
type: ProteinReference
xref: uniprot Q62469 1220
xref: PTHR23220:SF23
organism: Mus musculus

Suppressor of cytokine signaling 6
type: ProteinReference
xref: PTHR10155:SF17
xref: uniprot H9ERN5 1679
organism: Macaca mulatta

uniprot Q60860 144
type: UnificationXref
id: Q60860
db: uniprot

PTHR45627:SF11
type: RelationshipXref
id: PTHR45627:SF11
db: PANTHER Family
relationship type: By Homology

ALOX15 isoform 1
type: ProteinReference
xref: PTHR11771:SF33
xref: uniprot A0A2J8KQU9 125
organism: Pan troglodytes

JAK
type: ProteinReference
xref: P00846
standard name: Janus kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Janus kinase Synonym: Synonym not specified Accession: P00846
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.JAK
member entity reference: Tyrosine-protein kinase JAK2
member entity reference: Tyrosine-protein kinase
member entity reference: Non-receptor tyrosine-protein kinase TYK2

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
type: ProteinReference
xref: uniprot Q9BRC7 1525
organism: Homo sapiens

uniprot P54675 1387
type: UnificationXref
id: P54675
db: uniprot

uniprot O96624 1596
type: UnificationXref
id: O96624
db: uniprot

uniprot H2Q0T0 792
type: UnificationXref
id: H2Q0T0
db: uniprot

uniprot F6X927 1419
type: UnificationXref
id: F6X927
db: uniprot

uniprot P10981 997
type: UnificationXref
id: P10981
db: uniprot

uniprot H2QM91 686
type: UnificationXref
id: H2QM91
db: uniprot

PTHR12533:SF11
type: RelationshipXref
id: PTHR12533:SF11
db: PANTHER Family
relationship type: By Homology

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6XP81 61
organism: Xenopus tropicalis

uniprot P41597 725
type: UnificationXref
id: P41597
db: uniprot

uniprot Q0VBZ5 448
type: UnificationXref
id: Q0VBZ5
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q15147 1502
organism: Homo sapiens

uniprot Q9WVR3 455
type: UnificationXref
id: Q9WVR3
db: uniprot

uniprot H2RDM0 820
type: UnificationXref
id: H2RDM0
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A7RU31 897
organism: Nematostella vectensis

uniprot Q8CFN2 253
type: UnificationXref
id: Q8CFN2
db: uniprot

uniprot P49682 731
type: UnificationXref
id: P49682
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Plasma_membrane_phospholipid-RIGHT__Arachidonic_acid-_r81
controller: PLA2

uniprot H2QTA4 1207
type: UnificationXref
id: H2QTA4
db: uniprot

uniprot Q02788 1216
type: UnificationXref
id: Q02788
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F7G8G5 156
xref: PTHR11801:SF2
organism: Macaca mulatta

STAT
type: Protein
entity reference: STAT
feature: ACTIVE 46

Actin-5C
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P84185 1041
organism: Anopheles gambiae

Integrin
type: Protein
entity reference: Integrin
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Inactive phospholipase C-like protein 1
type: ProteinReference
xref: uniprot Q15111 1501
organism: Homo sapiens

uniprot F6YTJ1 1294
type: UnificationXref
id: F6YTJ1
db: uniprot

uniprot Q9JJL9 775
type: UnificationXref
id: Q9JJL9
db: uniprot

uniprot P13535 1322
type: UnificationXref
id: P13535
db: uniprot

Myosin-11
type: ProteinReference
xref: uniprot P10587 1316
xref: PTHR45615:SF23
organism: Gallus gallus

Predicted protein
type: ProteinReference
xref: PTHR11937:SF473
xref: uniprot A7SEB1 902
organism: Nematostella vectensis

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 25

Chemokine (C-X-C motif), receptor 4b
type: ProteinReference
xref: uniprot Q9PTF7 778
xref: PTHR10489:SF594
organism: Danio rerio

Nuclear factor of activated T cells 2
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot H2R4F5 617
organism: Pan troglodytes

Cytoplasmatic actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot E9FZ00 949
organism: Daphnia pulex

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

uniprot O55193 703
type: UnificationXref
id: O55193
db: uniprot

INHIBITION
type: RelationshipTypeVocabulary

C-X-C chemokine receptor type 5
type: ProteinReference
xref: uniprot Q04683 757
xref: PTHR10489:SF618
organism: Mus musculus

uniprot A0A2I3SMD5 801
type: UnificationXref
id: A0A2I3SMD5
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A7SEA7 901
organism: Nematostella vectensis

uniprot F1Q118 597
type: UnificationXref
id: F1Q118
db: uniprot

PANTHER Pathway P00031 1
type: UnificationXref
id: P00031
db: PANTHER Pathway

uniprot F7ALP1 972
type: UnificationXref
id: F7ALP1
db: uniprot

C-C motif chemokine 5
type: ProteinReference
xref: PTHR12015:SF170
xref: uniprot P30882 844
organism: Mus musculus

uniprot Q8WXR4 1345
type: UnificationXref
id: Q8WXR4
db: uniprot

uniprot P11798 570
type: UnificationXref
id: P11798
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: PTHR12644:SF1
xref: uniprot O15511 1590
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r32 1852
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

uniprot Q39027 293
type: UnificationXref
id: Q39027
db: uniprot

PARTICIPANT STOICHIOMETRY r32 1853
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF200
xref: uniprot G3X7B5 63
organism: Bos taurus

uniprot P10148 833
type: UnificationXref
id: P10148
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A0A1D5Q3D7 1431
organism: Macaca mulatta

Cdc42 protein, putative
type: ProteinReference
xref: uniprot B7PHY7 185
organism: Ixodes scapularis

C-C motif chemokine ligand 2
type: ProteinReference
xref: uniprot A0A2I3RVJ5 800
organism: Pan troglodytes

uniprot P19174 1492
type: UnificationXref
id: P19174
db: uniprot

uniprot Q9HF56 256
type: UnificationXref
id: Q9HF56
db: uniprot

uniprot Q5Z859 295
type: UnificationXref
id: Q5Z859
db: uniprot

uniprot P04049 518
type: UnificationXref
id: P04049
db: uniprot

uniprot A0A452DI16 512
type: UnificationXref
id: A0A452DI16
db: uniprot

uniprot A0A3P6PCS5 1551
type: UnificationXref
id: A0A3P6PCS5
db: uniprot

uniprot P35580 1326
type: UnificationXref
id: P35580
db: uniprot

Collagen type XIV alpha 1 chain
type: ProteinReference
xref: PTHR24020:SF15
xref: uniprot E2RT85 1194
organism: Canis lupus familiaris

uniprot F1PWZ2 1282
type: UnificationXref
id: F1PWZ2
db: uniprot

uniprot Q8HYQ1 871
type: UnificationXref
id: Q8HYQ1
db: uniprot

Rac family small GTPase 3b
type: ProteinReference
xref: uniprot A9JRY8 184
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZIB9 189
organism: Branchiostoma floridae

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot P34099 1167
xref: PTHR24353:SF37
organism: Dictyostelium discoideum

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot Q9Z1E3 885
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r39 1832
type: Stoichiometry
physical entity: F-actin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r39 1833
type: Stoichiometry
physical entity: F-actin
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot E2RT75 1449
organism: Canis lupus familiaris

Interleukin-36 alpha
type: ProteinReference
xref: uniprot Q9JLA2 1413
organism: Mus musculus

uniprot F7CYN6 168
type: UnificationXref
id: F7CYN6
db: uniprot

RHOG isoform 1
type: ProteinReference
xref: uniprot K7CGY0 210
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot P16520 349
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__Complex__Cytokine_receptor_IL2_-_STAT-_JAK-RIGHT__Complex__Cytokine_receptor_IL2__STAT_JAK__JAK_-_r87
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 1898
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 1897
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 1899
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 1896
left: STAT
left: JAK
left: Complex (Cytokine receptor/IL2)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Cytokine receptor/IL2/ STAT/JAK/ JAK)

Nuclear factor NF-kappa-B p105 subunit
type: ProteinReference
xref: PTHR24169:SF9
xref: uniprot P25799 1104
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot J9P702 344
xref: PTHR13809:SF9
organism: Canis lupus familiaris

uniprot Q63269 503
type: UnificationXref
id: Q63269
db: uniprot

uniprot P60766 225
type: UnificationXref
id: P60766
db: uniprot

uniprot A9TZ58 917
type: UnificationXref
id: A9TZ58
db: uniprot

Protein CBG02167
type: ProteinReference
xref: PTHR11937:SF470
xref: uniprot A8WS37 908
organism: Caenorhabditis briggsae

STATE_TRANSITION_LEFT__Plasma_membrane_phospholipid-RIGHT__Arachidonic_acid-_r81
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 1783
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 1782
left: Plasma membrane phospholipid
interaction type: STATE_TRANSITION
right: Arachidonic acid

uniprot Q3USB7 1507
type: UnificationXref
id: Q3USB7
db: uniprot

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: uniprot O70167 1379
xref: PTHR10048:SF29
organism: Mus musculus

PTHR12015:SF82
type: RelationshipXref
id: PTHR12015:SF82
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase PAK 4
type: ProteinReference
xref: uniprot O96013 411
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r63 1854
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r63 1855
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot F6TAH0 1462
xref: PTHR10336:SF173
organism: Monodelphis domestica

uniprot O00329 1377
type: UnificationXref
id: O00329
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__EMC-_Integrin-RIGHT__Complex__Integrin_EMC_-_r41
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 1828
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 1829
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 1827
left: EMC
left: Integrin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Integrin/EMC)

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A0A2I3RVP2 1437
organism: Pan troglodytes

Protein CBG02161
type: ProteinReference
xref: PTHR11937:SF471
xref: uniprot A8WS32 906
organism: Caenorhabditis briggsae

uniprot C3Z4K3 939
type: UnificationXref
id: C3Z4K3
db: uniprot

Protein CBG02162
type: ProteinReference
xref: PTHR11937:SF471
xref: uniprot A8WS33 907
organism: Caenorhabditis briggsae

uniprot F1R3G4 1285
type: UnificationXref
id: F1R3G4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF446
xref: uniprot C3ZHN2 940
organism: Branchiostoma floridae

uniprot F7HPR8 1232
type: UnificationXref
id: F7HPR8
db: uniprot

uniprot P12882 1319
type: UnificationXref
id: P12882
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6TQN3 1463
xref: PTHR10336:SF106
organism: Monodelphis domestica

PTHR12015:SF72
type: RelationshipXref
id: PTHR12015:SF72
db: PANTHER Family
relationship type: By Homology

Collagen alpha-6(VI) chain
type: ProteinReference
xref: PTHR22588:SF5
xref: uniprot Q8C6K9 1223
organism: Mus musculus

uniprot Q9WUA6 78
type: UnificationXref
id: Q9WUA6
db: uniprot

C-C chemokine receptor type 8
type: ProteinReference
xref: PTHR10489:SF627
xref: uniprot O97665 709
organism: Macaca mulatta

PTHR12015:SF73
type: RelationshipXref
id: PTHR12015:SF73
db: PANTHER Family
relationship type: By Homology

Collagen alpha-1(VI) chain
type: ProteinReference
xref: PTHR24020:SF18
xref: uniprot Q04857 1217
organism: Mus musculus

uniprot A7ETS6 896
type: UnificationXref
id: A7ETS6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF446
xref: uniprot C3ZHN4 941
organism: Branchiostoma floridae

uniprot G5EBH0 1471
type: UnificationXref
id: G5EBH0
db: uniprot

uniprot P60952 226
type: UnificationXref
id: P60952
db: uniprot

Formyl peptide receptor-related sequence 6
type: ProteinReference
xref: uniprot Q3SXG2 764
organism: Mus musculus

uniprot F7H998 1578
type: UnificationXref
id: F7H998
db: uniprot

C-X-C chemokine receptor type 6
type: ProteinReference
xref: uniprot Q9XT45 783
xref: PTHR10489:SF705
organism: Macaca mulatta

STATE_TRANSITION_LEFT__Arp2_3-RIGHT__Arp2_3-_r37
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 1840
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 1841
left: Arp2/3
interaction type: STATE_TRANSITION
right: Arp2/3

PIP2
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9CPW4 1632
type: UnificationXref
id: Q9CPW4
db: uniprot

uniprot P12111 1212
type: UnificationXref
id: P12111
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot F6RFW8 962
organism: Monodelphis domestica

uniprot Q5SX39 1335
type: UnificationXref
id: Q5SX39
db: uniprot

PARTICIPANT STOICHIOMETRY r27 1879
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

uniprot A0A2I3S4E5 1190
type: UnificationXref
id: A0A2I3S4E5
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QZN8 342
xref: PTHR13809:SF9
organism: Pan troglodytes

uniprot Q10DV7 1046
type: UnificationXref
id: Q10DV7
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42336 1381
organism: Homo sapiens

uniprot F6XUP1 400
type: UnificationXref
id: F6XUP1
db: uniprot

Lymphotoxin-alpha
type: ProteinReference
xref: uniprot Q06332 1412
organism: Rattus norvegicus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot P42338 1383
organism: Homo sapiens

Myosin-3
type: ProteinReference
xref: PTHR45615:SF6
xref: uniprot P11055 1318
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42337 1382
organism: Mus musculus

Myosin s73 a111 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Calcium/calmodulin-dependent serine protein kinase (MAGUK family)
type: ProteinReference
xref: PTHR23122:SF40
xref: uniprot F6UGQ3 558
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot G5EB66 1150
xref: PTHR24353:SF117
organism: Emericella nidulans

uniprot A0A2I3TL93 1550
type: UnificationXref
id: A0A2I3TL93
db: uniprot

ncbitaxon 6238 182
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot E1BP29 456
type: UnificationXref
id: E1BP29
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3S5ZPQ6 662
xref: PTHR10489:SF594
organism: Gallus gallus

uniprot O88302 24
type: UnificationXref
id: O88302
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot H9ZA60 1479
organism: Macaca mulatta

uniprot P11346 527
type: UnificationXref
id: P11346
db: uniprot

uniprot Q5RKP9 43
type: UnificationXref
id: Q5RKP9
db: uniprot

uniprot Q9QVP9 634
type: UnificationXref
id: Q9QVP9
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot Q9Z329 504
xref: PTHR13715:SF53
organism: Mus musculus

PTHR10218:SF217
type: RelationshipXref
id: PTHR10218:SF217
db: PANTHER Family
relationship type: By Homology

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot A0A3P6PCS5 1551
xref: PTHR10709:SF2
organism: Caenorhabditis elegans

NFATC3 isoform 2
type: ProteinReference
xref: uniprot K7DDW5 618
xref: PTHR12533:SF6
organism: Pan troglodytes

PTHR12015:SF94
type: RelationshipXref
id: PTHR12015:SF94
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot F6W7C8 1366
xref: PTHR10048:SF34
organism: Macaca mulatta

PTHR12015:SF92
type: RelationshipXref
id: PTHR12015:SF92
db: PANTHER Family
relationship type: By Homology

uniprot Q05769 538
type: UnificationXref
id: Q05769
db: uniprot

ncbitaxon 7227 76
type: UnificationXref
id: 7227
db: ncbitaxon

PTHR11419:SF0
type: RelationshipXref
id: PTHR11419:SF0
db: PANTHER Family
relationship type: By Homology

uniprot F1PJ01 1280
type: UnificationXref
id: F1PJ01
db: uniprot

uniprot C4M8K6 193
type: UnificationXref
id: C4M8K6
db: uniprot

uniprot Q9LMM5 304
type: UnificationXref
id: Q9LMM5
db: uniprot

uniprot E1B9K3 465
type: UnificationXref
id: E1B9K3
db: uniprot

uniprot Q13588 584
type: UnificationXref
id: Q13588
db: uniprot

uniprot K6ZCJ5 23
type: UnificationXref
id: K6ZCJ5
db: uniprot

uniprot P62737 1020
type: UnificationXref
id: P62737
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_r29
controller: PDK1

Integrin beta
type: ProteinReference
xref: uniprot E2RT60 641
xref: PTHR10082:SF28
organism: Canis lupus familiaris

uniprot F6QTB5 1568
type: UnificationXref
id: F6QTB5
db: uniprot

Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
type: ProteinReference
xref: uniprot D3ZS72 1535
xref: PTHR22829:SF6
organism: Rattus norvegicus

Adenylate cyclase type 6
type: ProteinReference
xref: PTHR45627:SF11
xref: uniprot P30804 474
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_r8
controller: Gbetagamma

uniprot A0A2I3RYR8 635
type: UnificationXref
id: A0A2I3RYR8
db: uniprot

RELB proto-oncogene, NF-kB subunit
type: ProteinReference
xref: uniprot F1PJ94 1099
organism: Canis lupus familiaris

JAK
type: Protein
entity reference: JAK
feature: COMPLEX PARTICIPANT BINDING FEATURE s105 sa47 1781
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q52WY2 245
type: UnificationXref
id: Q52WY2
db: uniprot

IKK s199 a131 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

C-C motif chemokine 20
type: ProteinReference
xref: PTHR12015:SF108
xref: uniprot Q8SQB1 875
organism: Bos taurus

PTHR11937:SF176
type: RelationshipXref
id: PTHR11937:SF176
db: PANTHER Family
relationship type: By Homology

G protein-coupled receptor kinase
type: ProteinReference
xref: uniprot E1BP29 456
xref: PTHR24355:SF15
organism: Bos taurus

PTHR12015:SF102
type: RelationshipXref
id: PTHR12015:SF102
db: PANTHER Family
relationship type: By Homology

PTHR12015:SF103
type: RelationshipXref
id: PTHR12015:SF103
db: PANTHER Family
relationship type: By Homology

NFAT5 isoform 6
type: ProteinReference
xref: uniprot K7DKR3 619
organism: Pan troglodytes

PTHR12015:SF108
type: RelationshipXref
id: PTHR12015:SF108
db: PANTHER Family
relationship type: By Homology

Suppressor of cytokine-signaling 6
type: ProteinReference
xref: PTHR10155:SF17
xref: uniprot D3ZS84 1668
organism: Rattus norvegicus

C-C motif chemokine 3
type: ProteinReference
xref: uniprot P50229 848
organism: Rattus norvegicus

uniprot Q7YQL4 422
type: UnificationXref
id: Q7YQL4
db: uniprot

uniprot P60483 593
type: UnificationXref
id: P60483
db: uniprot

uniprot P67813 854
type: UnificationXref
id: P67813
db: uniprot

PIP3
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q07FZ4 758
type: UnificationXref
id: Q07FZ4
db: uniprot

Myosin
type: ProteinReference
xref: P00867
comment: ENTITY_REFERENCE_NOTES=Long Name: Myosin Synonym: Synonym not specified Accession: P00867
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.Myosin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Uncharacterized protein
member entity reference: Myosin heavy chain 11
member entity reference: Myosin heavy chain 7B
member entity reference: Myosin IIIA
member entity reference: Myosin heavy chain 10
member entity reference: Myosin heavy chain, non-muscle
member entity reference: Myosin-10
member entity reference: Myosin-11
member entity reference: Myosin-14
member entity reference: Myosin heavy chain 4
member entity reference: Myosin heavy chain 2
member entity reference: Myosin-7B
member entity reference: MYH4 isoform 1
member entity reference: Myosin-7
member entity reference: Myosin-IIIb
member entity reference: Myosin, heavy chain b
member entity reference: Myosin, heavy polypeptide 2, fast muscle-specific
member entity reference: Myosin-6
member entity reference: Myosin heavy chain 9
member entity reference: Myosin-4
member entity reference: MYH3 protein
member entity reference: MYH11 protein
member entity reference: MYH14 isoform 6
member entity reference: Myosin, heavy chain a
member entity reference: Myosin-1
member entity reference: Myosin-IIIa
member entity reference: Myosin-1B
member entity reference: Myosin-8
member entity reference: Myosin, heavy chain 9, non-muscle
member entity reference: Neither inactivation nor afterpotential protein C
member entity reference: Myosin heavy chain 14
member entity reference: Myosin, heavy chain 10, non-muscle
member entity reference: MYO3A isoform 1
member entity reference: Myosin, heavy polypeptide 1.1, skeletal muscle
member entity reference: Myosin, heavy polypeptide 1.2, skeletal muscle
member entity reference: Myosin-3
member entity reference: Myosin heavy chain 6
member entity reference: Myosin-9
member entity reference: MYH9 isoform 1
member entity reference: MCG140437, isoform CRA_d
member entity reference: Myosin-2
member entity reference: Developmental myosin heavy chain embryonic

Cytohesin 2
type: ProteinReference
xref: uniprot A0A2I3SWV7 1533
xref: PTHR10663:SF343
organism: Pan troglodytes

CD42_CHICK Cell division control protein 42 homolog (G25K GTP-binding protein)MODA
type: ProteinReference
xref: uniprot G5EAY4 206
organism: Emericella nidulans

PTHR11937:SF168
type: RelationshipXref
id: PTHR11937:SF168
db: PANTHER Family
relationship type: By Homology

Cytokine receptor s55 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cytokine receptor
stoichiometric coefficient: 2.0

uniprot F1MM57 1272
type: UnificationXref
id: F1MM57
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Pro_inflammatory_anti_apoptotic_genes-RIGHT__pro_inflammatory_anti_apoptotic_genes-_re71
control type: ACTIVATION
controller: NFkappaB

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q4KLF8 1619
xref: PTHR12644:SF1
organism: Rattus norvegicus

C-C motif chemokine 4
type: ProteinReference
xref: uniprot P50230 849
organism: Rattus norvegicus

C-C motif chemokine 5
type: ProteinReference
xref: PTHR12015:SF170
xref: uniprot P50231 850
organism: Rattus norvegicus

PTHR11937:SF162
type: RelationshipXref
id: PTHR11937:SF162
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r87 1896
type: Stoichiometry
physical entity: Complex (Cytokine receptor/IL2)
stoichiometric coefficient: 1.0

uniprot H2RII6 1678
type: UnificationXref
id: H2RII6
db: uniprot

PARTICIPANT STOICHIOMETRY r87 1898
type: Stoichiometry
physical entity: JAK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r87 1897
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

uniprot Q8C015 424
type: UnificationXref
id: Q8C015
db: uniprot

PARTICIPANT STOICHIOMETRY r87 1899
type: Stoichiometry
physical entity: Complex (Cytokine receptor/IL2/ STAT/JAK/ JAK)
stoichiometric coefficient: 1.0

Myosin-6
type: ProteinReference
xref: uniprot Q02566 1328
xref: PTHR45615:SF11
organism: Mus musculus

ROCK
type: Protein
entity reference: ROCK
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot H3FK05 208
organism: Pristionchus pacificus

uniprot P51677 734
type: UnificationXref
id: P51677
db: uniprot

PTHR11937:SF154
type: RelationshipXref
id: PTHR11937:SF154
db: PANTHER Family
relationship type: By Homology

uniprot Q10316 1611
type: UnificationXref
id: Q10316
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot F7H6T2 1149
organism: Macaca mulatta

PTHR11937:SF150
type: RelationshipXref
id: PTHR11937:SF150
db: PANTHER Family
relationship type: By Homology

Collagen type VI alpha 3 chain
type: ProteinReference
xref: PTHR24020:SF13
xref: uniprot H2QJP2 1205
organism: Pan troglodytes

uniprot Q9QXY8 878
type: UnificationXref
id: Q9QXY8
db: uniprot

uniprot O96623 1595
type: UnificationXref
id: O96623
db: uniprot

uniprot F6VQA9 677
type: UnificationXref
id: F6VQA9
db: uniprot

uniprot Q1RMI2 240
type: UnificationXref
id: Q1RMI2
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F6QUW1 598
organism: Monodelphis domestica

uniprot P35407 723
type: UnificationXref
id: P35407
db: uniprot

uniprot E7EXT6 53
type: UnificationXref
id: E7EXT6
db: uniprot

uniprot Q6IQL9 1064
type: UnificationXref
id: Q6IQL9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BX17 1646
xref: PTHR24347:SF373
organism: Gallus gallus

uniprot O55145 824
type: UnificationXref
id: O55145
db: uniprot

uniprot P35411 724
type: UnificationXref
id: P35411
db: uniprot

uniprot Q922R0 1185
type: UnificationXref
id: Q922R0
db: uniprot

uniprot A0A2I3TGI5 1093
type: UnificationXref
id: A0A2I3TGI5
db: uniprot

PTHR45807:SF1
type: RelationshipXref
id: PTHR45807:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q08BT6 1140
type: UnificationXref
id: Q08BT6
db: uniprot

PTHR45807:SF6
type: RelationshipXref
id: PTHR45807:SF6
db: PANTHER Family
relationship type: By Homology

Phospholipase A2
type: ProteinReference
evidence: Evidence 786
xref: PTHR10728:SF13
xref: uniprot F6UQ33 788
organism: Canis lupus familiaris

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa15 1721
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P97492 175
type: UnificationXref
id: P97492
db: uniprot

uniprot F1M0G0 167
type: UnificationXref
id: F1M0G0
db: uniprot

uniprot P68181 1170
type: UnificationXref
id: P68181
db: uniprot

uniprot E1BH60 1447
type: UnificationXref
id: E1BH60
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q28024 368
xref: PTHR13809:SF9
organism: Bos taurus

uniprot P53731 1603
type: UnificationXref
id: P53731
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot A8XT67 1557
xref: PTHR10709:SF2
organism: Caenorhabditis briggsae

PTHR24351:SF182
type: RelationshipXref
id: PTHR24351:SF182
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XWE8 326
xref: PTHR13809:SF8
organism: Monodelphis domestica

uniprot F6U6I0 675
type: UnificationXref
id: F6U6I0
db: uniprot

uniprot P58798 1604
type: UnificationXref
id: P58798
db: uniprot

Signal transducer and activator of transcription 3
type: ProteinReference
xref: uniprot P40763 157
xref: PTHR11801:SF2
organism: Homo sapiens

STATE_TRANSITION_LEFT__PYK2-RIGHT__PYK2-_r18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 1791
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 1790
left: PYK2
interaction type: STATE_TRANSITION
right: PYK2

uniprot E1BQN6 120
type: UnificationXref
id: E1BQN6
db: uniprot

PYK2
type: Protein
entity reference: PYK2
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot O18793 700
type: UnificationXref
id: O18793
db: uniprot

uniprot Q6U2D6 767
type: UnificationXref
id: Q6U2D6
db: uniprot

Myosin heavy chain 7B
type: ProteinReference
xref: PTHR45615:SF29
xref: uniprot F1PWZ2 1282
organism: Canis lupus familiaris

UNKNOWN_TRANSITION
type: InteractionVocabulary

uniprot Q9V3Q6 1231
type: UnificationXref
id: Q9V3Q6
db: uniprot

Collagen alpha-1(VI) chain
type: ProteinReference
xref: PTHR24020:SF18
xref: uniprot P12109 1210
organism: Homo sapiens

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot B2RZ72 1559
organism: Rattus norvegicus

Collagen alpha-2(VI) chain
type: ProteinReference
xref: uniprot P12110 1211
xref: PTHR24020:SF29
organism: Homo sapiens

Collagen alpha-3(VI) chain
type: ProteinReference
xref: PTHR24020:SF13
xref: uniprot P12111 1212
organism: Homo sapiens

uniprot P42227 159
type: UnificationXref
id: P42227
db: uniprot

PYK2
type: Protein
entity reference: PYK2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot J9NRZ4 436
type: UnificationXref
id: J9NRZ4
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Cytokine_receptor-_IL2-RIGHT__Complex__Cytokine_receptor_IL2_-_r86
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 1903
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 1904
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 1902
left: Cytokine receptor
left: IL2
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Cytokine receptor/IL2)

C-C motif chemokine
type: ProteinReference
xref: PTHR12015:SF108
xref: uniprot H2R2S1 818
organism: Pan troglodytes

Myosin light chain kinase 2
type: ProteinReference
xref: PTHR24347:SF373
xref: uniprot H2QK55 1649
organism: Pan troglodytes

uniprot F7HLU2 682
type: UnificationXref
id: F7HLU2
db: uniprot

PTHR11937:SF193
type: RelationshipXref
id: PTHR11937:SF193
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF192
type: RelationshipXref
id: PTHR11937:SF192
db: PANTHER Family
relationship type: By Homology

uniprot G3X7B5 63
type: UnificationXref
id: G3X7B5
db: uniprot

uniprot F6W548 324
type: UnificationXref
id: F6W548
db: uniprot

C-X-C chemokine receptor type 4
type: ProteinReference
xref: uniprot P70658 749
xref: PTHR10489:SF594
organism: Mus musculus

uniprot F1Q2Y3 147
type: UnificationXref
id: F1Q2Y3
db: uniprot

uniprot P04388 1405
type: UnificationXref
id: P04388
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E823 269
xref: PTHR24055:SF203
organism: Monodelphis domestica

Inositol polyphosphate phosphatase like 1
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot F1PNY0 451
organism: Canis lupus familiaris

uniprot J9P893 693
type: UnificationXref
id: J9P893
db: uniprot

CHK s208 sa160 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHK
stoichiometric coefficient: 1.0

Proto-oncogene vav
type: ProteinReference
xref: uniprot P15498 1542
xref: PTHR45818:SF2
organism: Homo sapiens

Pro-inflammatory genes
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UGY3 559
xref: PTHR24347:SF365
organism: Macaca mulatta

PTHR11937:SF184
type: RelationshipXref
id: PTHR11937:SF184
db: PANTHER Family
relationship type: By Homology

uniprot P30671 350
type: UnificationXref
id: P30671
db: uniprot

uniprot P84444 860
type: UnificationXref
id: P84444
db: uniprot

uniprot A0A2I3STB7 552
type: UnificationXref
id: A0A2I3STB7
db: uniprot

C-C chemokine receptor-like 2
type: ProteinReference
xref: uniprot O00421 694
organism: Homo sapiens

Myosin light chain kinase 3
type: ProteinReference
xref: PTHR24347:SF394
xref: uniprot H2QB15 1648
organism: Pan troglodytes

C-X-C motif chemokine receptor 5
type: ProteinReference
xref: uniprot A0A2I3S7U4 659
xref: PTHR10489:SF618
organism: Pan troglodytes

Myosin light chain kinase, smooth muscle
type: ProteinReference
xref: PTHR47633:SF1
xref: uniprot Q28824 1654
organism: Bos taurus

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 52

Nuclear factor of activated T-cells, cytoplasmic 3
type: ProteinReference
xref: uniprot P97305 622
xref: PTHR12533:SF6
organism: Mus musculus

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot Q08BT6 1140
xref: PTHR24356:SF159
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot A0A3Q1NGS8 308
organism: Bos taurus

uniprot E1BE66 1360
type: UnificationXref
id: E1BE66
db: uniprot

GTPase cRac1A
type: ProteinReference
xref: uniprot Q6LC82 249
organism: Gallus gallus

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot Q80TL1 480
xref: PTHR45627:SF6
organism: Mus musculus

uniprot H2QPN4 813
type: UnificationXref
id: H2QPN4
db: uniprot

PTHR20859:SF5
type: RelationshipXref
id: PTHR20859:SF5
db: PANTHER Family
relationship type: By Homology

Calcium/calmodulin-dependent protein kinase type II subunit gamma
type: ProteinReference
xref: PTHR24347:SF398
xref: uniprot P11730 569
organism: Rattus norvegicus

uniprot O70293 459
type: UnificationXref
id: O70293
db: uniprot

uniprot A0A1D5RJ76 627
type: UnificationXref
id: A0A1D5RJ76
db: uniprot

Cytokine receptor
type: Protein
entity reference: Cytokine receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s99 sa44 1775
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q9R0M1 779
type: UnificationXref
id: Q9R0M1
db: uniprot

ncbitaxon 10228 922
type: UnificationXref
id: 10228
db: ncbitaxon

uniprot F7FY59 458
type: UnificationXref
id: F7FY59
db: uniprot

C-X3-C motif chemokine ligand 1
type: ProteinReference
xref: PTHR12015:SF92
xref: uniprot H2QB68 810
organism: Pan troglodytes

Actin-related protein 2/3 complex subunit 1A
type: ProteinReference
xref: PTHR10709:SF2
xref: uniprot O80856 1592
organism: Arabidopsis thaliana

Myosin-7B
type: ProteinReference
xref: PTHR45615:SF29
xref: uniprot A7E2Y1 1263
organism: Homo sapiens

Os12g0163700 protein
type: ProteinReference
xref: PTHR11937:SF474
xref: uniprot Q0IPW3 1044
organism: Oryza sativa

ncbitaxon 9544 6
type: UnificationXref
id: 9544
db: ncbitaxon

MAPK s197 a239 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

STATE_TRANSITION_LEFT__PKCzeta-RIGHT__PKCzeta-_r40
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 1830
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 1831
left: PKCzeta
interaction type: STATE_TRANSITION
right: PKCzeta

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot P21278 28
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot F7GI54 336
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: uniprot P21279 31
organism: Mus musculus

uniprot P10720 834
type: UnificationXref
id: P10720
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7EH19 270
xref: PTHR24055:SF203
organism: Xenopus tropicalis

uniprot F7DIB7 974
type: UnificationXref
id: F7DIB7
db: uniprot

Protein CBR-ACT-2
type: ProteinReference
xref: PTHR11937:SF471
xref: uniprot A8Y4Q9 910
organism: Caenorhabditis briggsae

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P68404 1138
organism: Mus musculus

Collagen, type VI, alpha 3
type: ProteinReference
xref: PTHR24020:SF13
xref: uniprot E9PWQ3 1195
organism: Mus musculus

eco ECO:0000305 348
type: UnificationXref
id: ECO:0000305
db: eco

PTHR12644:SF0
type: RelationshipXref
id: PTHR12644:SF0
db: PANTHER Family
relationship type: By Homology

PTHR12644:SF1
type: RelationshipXref
id: PTHR12644:SF1
db: PANTHER Family
relationship type: By Homology

PTHR12644:SF2
type: RelationshipXref
id: PTHR12644:SF2
db: PANTHER Family
relationship type: By Homology

PTHR12644:SF3
type: RelationshipXref
id: PTHR12644:SF3
db: PANTHER Family
relationship type: By Homology

Rho-related GTP-binding protein RhoG
type: ProteinReference
xref: uniprot F6ZFI9 202
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZZG9 970
xref: PTHR11937:SF168
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G124 1301
xref: PTHR45615:SF11
organism: Macaca mulatta

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot F6VVA6 1464
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r10 1824
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

uniprot P06245 1161
type: UnificationXref
id: P06245
db: uniprot

PARTICIPANT STOICHIOMETRY r10 1823
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 1900
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: PTHR13809:SF9
xref: uniprot Q9UBI6 378
organism: Homo sapiens

uniprot F6TQN3 1463
type: UnificationXref
id: F6TQN3
db: uniprot

Ras-related protein Rac1
type: ProteinReference
xref: uniprot P40792 222
organism: Drosophila melanogaster

C-C motif chemokine 13
type: ProteinReference
xref: uniprot Q99616 877
organism: Homo sapiens

Cdc42 homolog
type: ProteinReference
xref: uniprot P40793 223
organism: Drosophila melanogaster

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot H2QAS6 1133
organism: Pan troglodytes

uniprot O00626 823
type: UnificationXref
id: O00626
db: uniprot

uniprot P08505 1409
type: UnificationXref
id: P08505
db: uniprot

uniprot Q0IIE2 1236
type: UnificationXref
id: Q0IIE2
db: uniprot

uniprot F7ES96 333
type: UnificationXref
id: F7ES96
db: uniprot

Myosin heavy chain 4
type: ProteinReference
xref: PTHR45615:SF43
xref: uniprot E1BP87 1270
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r23 1901
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

ncbitaxon 8364 17
type: UnificationXref
id: 8364
db: ncbitaxon

Grb
type: Protein
entity reference: Grb
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa37 1747
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P63097 108
type: UnificationXref
id: P63097
db: uniprot

Tyrosine-protein kinase JAK2
type: ProteinReference
xref: uniprot O60674 547
xref: PTHR45807:SF1
organism: Homo sapiens

PTHR22969:SF10
type: RelationshipXref
id: PTHR22969:SF10
db: PANTHER Family
relationship type: By Homology

GDP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9606 27
type: UnificationXref
id: 9606
db: ncbitaxon

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot D4A0I8 609
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r27 1880
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: uniprot O75914 409
xref: PTHR48015:SF30
organism: Homo sapiens

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P47196 68
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: uniprot O95837 26
organism: Homo sapiens

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P47197 69
organism: Rattus norvegicus

C-C chemokine receptor-like 2
type: ProteinReference
xref: uniprot Q9XSD7 782
organism: Macaca mulatta

Protein CBG23090
type: ProteinReference
xref: PTHR11937:SF470
xref: uniprot A8Y4R0 911
organism: Caenorhabditis briggsae

Protein-tyrosine kinase 2-beta
type: ProteinReference
xref: uniprot P70600 632
xref: PTHR24418:SF94
organism: Rattus norvegicus

ncbitaxon 184922 904
type: UnificationXref
id: 184922
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ASR8 328
xref: PTHR13809:SF52
organism: Macaca mulatta

uniprot F7GUA3 680
type: UnificationXref
id: F7GUA3
db: uniprot

uniprot Q63921 539
type: UnificationXref
id: Q63921
db: uniprot

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF0
xref: uniprot E1C8Y3 1561
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r82 1914
type: Stoichiometry
physical entity: Arachidonic acid
stoichiometric coefficient: 1.0

Suppressor of cytokine signaling 5
type: ProteinReference
xref: PTHR10155:SF15
xref: uniprot F7GUL4 1676
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r82 1915
type: Stoichiometry
physical entity: Leukotriene
stoichiometric coefficient: 1.0

uniprot O75159 1684
type: UnificationXref
id: O75159
db: uniprot

Shc s27 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Shc
stoichiometric coefficient: 1.0

Actin, aortic smooth muscle
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot P62736 1019
organism: Homo sapiens

uniprot D3ZQF8 1095
type: UnificationXref
id: D3ZQF8
db: uniprot

cAMP-dependent protein kinase type 3
type: ProteinReference
xref: uniprot Q3Y3Z2 1174
xref: PTHR24353:SF117
organism: Neurospora crassa

Actin, aortic smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot P62739 1021
organism: Bos taurus

uniprot F7FHD1 272
type: UnificationXref
id: F7FHD1
db: uniprot

Actin, aortic smooth muscle
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot P62737 1020
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR24347:SF384
xref: uniprot A0A3Q1MKC7 556
organism: Bos taurus

uniprot F1MQ37 1273
type: UnificationXref
id: F1MQ37
db: uniprot

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: uniprot Q7YQL4 422
xref: PTHR48015:SF30
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r58 1882
type: Stoichiometry
physical entity: JAK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 1883
type: Stoichiometry
physical entity: Complex (Cytokine receptor/JAK/ JAK/INFgamma)
stoichiometric coefficient: 1.0

PTHR24070:SF189
type: RelationshipXref
id: PTHR24070:SF189
db: PANTHER Family
relationship type: By Homology

Integrin beta
type: ProteinReference
xref: uniprot F6PNT9 642
xref: PTHR10082:SF28
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r58 1881
type: Stoichiometry
physical entity: Complex (Cytokine receptor/INFgamma)
stoichiometric coefficient: 1.0

uniprot F6VQP7 490
type: UnificationXref
id: F6VQP7
db: uniprot

uniprot A0A1D5R0L5 1189
type: UnificationXref
id: A0A1D5R0L5
db: uniprot

uniprot F6VL43 90
type: UnificationXref
id: F6VL43
db: uniprot

PARTICIPANT STOICHIOMETRY r25 1889
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot E2QWU0 1562
organism: Canis lupus familiaris

PDK1
type: Protein
entity reference: PDK1
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F2Z4N8 959
type: UnificationXref
id: F2Z4N8
db: uniprot

uniprot Q9VQD8 1640
type: UnificationXref
id: Q9VQD8
db: uniprot

C3a anaphylatoxin chemotactic receptor
type: ProteinReference
xref: uniprot O09047 699
xref: PTHR24225:SF28
organism: Mus musculus

uniprot C3XYC2 926
type: UnificationXref
id: C3XYC2
db: uniprot

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot P26769 473
xref: PTHR45627:SF6
organism: Rattus norvegicus

uniprot K7CGY0 210
type: UnificationXref
id: K7CGY0
db: uniprot

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r25
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 1889
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 1890
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

PTHR45818:SF2
type: RelationshipXref
id: PTHR45818:SF2
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r25 1890
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot A2AQP0 1259
type: UnificationXref
id: A2AQP0
db: uniprot

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__EMC-_Integrin-RIGHT__Complex__Integrin_EMC_-_r41
controller: PKCzeta

Sos s28 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Sos
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot P48736 1384
organism: Homo sapiens

uniprot Q9Z2A0 151
type: UnificationXref
id: Q9Z2A0
db: uniprot

uniprot P30679 35
type: UnificationXref
id: P30679
db: uniprot

PDK1
type: Protein
entity reference: PDK1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A0A0G2K9S1 1665
type: UnificationXref
id: A0A0G2K9S1
db: uniprot

uniprot Q00651 657
type: UnificationXref
id: Q00651
db: uniprot

uniprot A0A3Q1M353 511
type: UnificationXref
id: A0A3Q1M353
db: uniprot

Myosin heavy chain 11
type: ProteinReference
xref: PTHR45615:SF23
xref: uniprot F1PJ01 1280
organism: Canis lupus familiaris

uniprot P08487 1484
type: UnificationXref
id: P08487
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05412 438
organism: Homo sapiens

Gbetagamma
type: Protein
entity reference: Gbetagamma
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P38409 37
type: UnificationXref
id: P38409
db: uniprot

Complex (Cytokine receptor/IL2)
type: Complex
component stoichiometry: Cytokine receptor s95 sa42 STOICHIOMETRY ID COMPLEX
component stoichiometry: IL2 s98 sa43 STOICHIOMETRY ID COMPLEX
component: IL2
component: Cytokine receptor
feature: COMPLEX BINDING FEATURE s193 a278 1764
feature: COMPLEX BINDING FEATURE s193 a278 1766
cellular location: cytoplasm

uniprot F7A567 204
type: UnificationXref
id: F7A567
db: uniprot

uniprot Q05707 1218
type: UnificationXref
id: Q05707
db: uniprot

uniprot A0A0D1C4Y4 259
type: UnificationXref
id: A0A0D1C4Y4
db: uniprot

NFATC4 isoform 9
type: ProteinReference
xref: PTHR12533:SF11
xref: uniprot A0A2I3TJ60 606
organism: Pan troglodytes

uniprot Q5E9B5 1054
type: UnificationXref
id: Q5E9B5
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9TVP1 914
organism: Physcomitrella patens

ncbitaxon 3055 303
type: UnificationXref
id: 3055
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF44
xref: uniprot F7G117 1300
organism: Macaca mulatta

uniprot A0A1D5Q3D7 1431
type: UnificationXref
id: A0A1D5Q3D7
db: uniprot

uniprot Q7PUF2 1625
type: UnificationXref
id: Q7PUF2
db: uniprot

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

PTHR10337:SF2
type: RelationshipXref
id: PTHR10337:SF2
db: PANTHER Family
relationship type: By Homology

AKT
type: Protein
entity reference: AKT
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F1MYW8 316
type: UnificationXref
id: F1MYW8
db: uniprot

uniprot A0A2I3TFM8 82
type: UnificationXref
id: A0A2I3TFM8
db: uniprot

uniprot P40763 157
type: UnificationXref
id: P40763
db: uniprot

uniprot Q8R3B1 1520
type: UnificationXref
id: Q8R3B1
db: uniprot

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q9Z2A0 151
organism: Mus musculus

Myosin light chain kinase, smooth muscle
type: ProteinReference
xref: uniprot P11799 1650
xref: PTHR47633:SF1
organism: Gallus gallus

uniprot P32871 1380
type: UnificationXref
id: P32871
db: uniprot

uniprot Q62688 1511
type: UnificationXref
id: Q62688
db: uniprot

uniprot P18054 133
type: UnificationXref
id: P18054
db: uniprot

cAMP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P09450 440
type: UnificationXref
id: P09450
db: uniprot

Formyl peptide receptor-related sequence 1
type: ProteinReference
xref: uniprot O08790 698
organism: Mus musculus

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot F6U298 1229
organism: Xenopus tropicalis

uniprot P59998 1605
type: UnificationXref
id: P59998
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7FHD1 272
xref: PTHR24055:SF203
organism: Monodelphis domestica

uniprot P22694 1165
type: UnificationXref
id: P22694
db: uniprot

Calcium/calmodulin-dependent protein kinase type II subunit alpha
type: ProteinReference
xref: PTHR24347:SF384
xref: uniprot P11798 570
organism: Mus musculus

uniprot P47713 794
type: UnificationXref
id: P47713
db: uniprot

PTHR11771:SF33
type: RelationshipXref
id: PTHR11771:SF33
db: PANTHER Family
relationship type: By Homology

Cdc42
type: ProteinReference
xref: P00834
standard name: Cell division cycle 42
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Cell division cycle 42 Synonym: 25 KD GTP-binding protein,G25K Accession: P00834
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.Cdc42
member entity reference: Protein CBR-MIG-2
member entity reference: Rho-related protein rac1B
member entity reference: Ras-related protein ced-10
member entity reference: Ras-related C3 botulinum toxin substrate 1
member entity reference: Cell division control protein 42 homolog
member entity reference: Uncharacterized protein
member entity reference: Cdc42 homolog
member entity reference: GTPase cRac1A
member entity reference: Rho-related protein racA
member entity reference: Ras-related C3 botulinum toxin substrate 2
member entity reference: Rac family small GTPase 1b
member entity reference: Cell division cycle 42
member entity reference: Rho family GTPase
member entity reference: Ras homolog family member G
member entity reference: Ras homolog gene family, member G (Rho G)
member entity reference: Rac family small GTPase 1a
member entity reference: Rac family small GTPase 3b
member entity reference: Protein CBR-CDC-42
member entity reference: Rho-related GTP-binding protein RhoG
member entity reference: Rac1B, RHO family GTPase
member entity reference: Cdc42 protein, putative
member entity reference: Rac family small GTPase 1
member entity reference: Cell division control protein 42
member entity reference: Rac family small GTPase 3a
member entity reference: Rho-related protein rac1C
member entity reference: Ras-related protein Rac2
member entity reference: Cell division control protein 42 homolog isoform 2
member entity reference: Ras-related protein rac-2
member entity reference: CD42_CHICK Cell division control protein 42 homolog (G25K GTP-binding protein)MODA
member entity reference: Ras-related protein Rac1
member entity reference: Rac family small GTPase 2
member entity reference: RHOG isoform 1
member entity reference: AGAP001573-PA
member entity reference: Rac family small GTPase 3
member entity reference: Uncharacterized protein rac1A
member entity reference: Rho-related protein racB
member entity reference: Rho-related protein rac1A
member entity reference: AT17867p
member entity reference: Rac-like GTPase

PTHR11771:SF34
type: RelationshipXref
id: PTHR11771:SF34
db: PANTHER Family
relationship type: By Homology

uniprot P63216 364
type: UnificationXref
id: P63216
db: uniprot

AKT
type: Protein
entity reference: AKT
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P07830 993
type: UnificationXref
id: P07830
db: uniprot

uniprot P63268 1027
type: UnificationXref
id: P63268
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A2G1K5 893
organism: Trichomonas vaginalis

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NM49 1277
xref: PTHR45615:SF26
organism: Gallus gallus

AGAP011840-PA (Fragment)
type: ProteinReference
xref: uniprot Q7PZC6 1182
xref: PTHR24353:SF37
organism: Anopheles gambiae

uniprot P05131 1157
type: UnificationXref
id: P05131
db: uniprot

Actin-2
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q8ILW9 1080
organism: Plasmodium falciparum

uniprot F1MLS3 1452
type: UnificationXref
id: F1MLS3
db: uniprot

uniprot P51685 742
type: UnificationXref
id: P51685
db: uniprot

PI-3 kinase
type: ProteinReference
xref: uniprot P91634 1388
organism: Drosophila melanogaster

uniprot A0A1D5RHE7 464
type: UnificationXref
id: A0A1D5RHE7
db: uniprot

uniprot Q7ZVK8 300
type: UnificationXref
id: Q7ZVK8
db: uniprot

C-C motif chemokine 20
type: ProteinReference
xref: PTHR12015:SF108
xref: uniprot P78556 856
organism: Homo sapiens

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 27

Regulator of G-protein signaling 14
type: ProteinReference
xref: uniprot O08773 171
xref: PTHR45945:SF2
organism: Rattus norvegicus

uniprot Q62812 1338
type: UnificationXref
id: Q62812
db: uniprot

uniprot A0A1D5QVF5 1250
type: UnificationXref
id: A0A1D5QVF5
db: uniprot

uniprot P54673 1385
type: UnificationXref
id: P54673
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A2FA04 891
organism: Trichomonas vaginalis

uniprot P35343 722
type: UnificationXref
id: P35343
db: uniprot

uniprot F1QCB2 672
type: UnificationXref
id: F1QCB2
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha isoform 1
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H9EQQ4 1155
organism: Macaca mulatta

PTHR24225:SF15
type: RelationshipXref
id: PTHR24225:SF15
db: PANTHER Family
relationship type: By Homology

ROCK
type: ProteinReference
xref: P00881
standard name: Rho-associated coiled-coil Ser/Thr specific kinase
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.ROCK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Rho-associated coiled-coil Ser/Thr specific kinase Synonym: ROCK Accession: P00881
member entity reference: Rho-associated protein kinase 1
member entity reference: Rho associated coiled-coil containing protein kinase 1
member entity reference: Rho-associated protein kinase

uniprot E2RNA9 1417
type: UnificationXref
id: E2RNA9
db: uniprot

uniprot Q8BTI9 1390
type: UnificationXref
id: Q8BTI9
db: uniprot

uniprot Q380U3 244
type: UnificationXref
id: Q380U3
db: uniprot

PTHR24072:SF153
type: RelationshipXref
id: PTHR24072:SF153
db: PANTHER Family
relationship type: By Homology

uniprot Q7ZUQ0 1627
type: UnificationXref
id: Q7ZUQ0
db: uniprot

uniprot Q05933 1610
type: UnificationXref
id: Q05933
db: uniprot

uniprot Q5ZMQ2 1059
type: UnificationXref
id: Q5ZMQ2
db: uniprot

Myosin, heavy chain b
type: ProteinReference
xref: uniprot F1QVX3 1284
organism: Danio rerio

uniprot P10749 1410
type: UnificationXref
id: P10749
db: uniprot

uniprot Q923T9 581
type: UnificationXref
id: Q923T9
db: uniprot

Calcium/calmodulin-dependent protein kinase type II subunit gamma
type: ProteinReference
xref: PTHR24347:SF398
xref: uniprot Q923T9 581
organism: Mus musculus

Lipoxygenase
type: Protein
entity reference: Lipoxygenase
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

C-C motif chemokine 18
type: ProteinReference
xref: PTHR12015:SF94
xref: uniprot P55774 852
organism: Homo sapiens

C-X-C chemokine receptor type 2
type: ProteinReference
xref: PTHR10489:SF689
xref: uniprot Q28003 759
organism: Bos taurus

uniprot P60953 227
type: UnificationXref
id: P60953
db: uniprot

uniprot Q39021 288
type: UnificationXref
id: Q39021
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24347:SF384
xref: uniprot F1NGS8 557
organism: Gallus gallus

Formyl peptide receptor,-related sequence 4
type: ProteinReference
xref: uniprot D4A942 666
organism: Rattus norvegicus

uniprot W4Y969 1089
type: UnificationXref
id: W4Y969
db: uniprot

uniprot F1Q4F8 56
type: UnificationXref
id: F1Q4F8
db: uniprot

uniprot P39654 139
type: UnificationXref
id: P39654
db: uniprot

PTHR24225:SF29
type: RelationshipXref
id: PTHR24225:SF29
db: PANTHER Family
relationship type: By Homology

PTHR24225:SF28
type: RelationshipXref
id: PTHR24225:SF28
db: PANTHER Family
relationship type: By Homology

Integrin alpha-4
type: ProteinReference
xref: PTHR23220:SF78
xref: uniprot Q00651 657
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r5 1794
type: Stoichiometry
physical entity: Complex (CHKR/CHK/ Galphai/q/ GDP/Gbetagamma)
stoichiometric coefficient: 1.0

Protein-tyrosine kinase 2-beta
type: ProteinReference
xref: PTHR24418:SF94
xref: uniprot Q14289 633
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r5 1795
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 1796
type: Stoichiometry
physical entity: Complex (Galphai/q/ GTP)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 1797
type: Stoichiometry
physical entity: Complex (CHKR/CHK)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 1798
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Nuclear factor NF-kappa-B p100 subunit
type: ProteinReference
xref: uniprot Q00653 1105
xref: PTHR24169:SF21
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r5 1799
type: Stoichiometry
physical entity: Gbetagamma
stoichiometric coefficient: 1.0

PTHR24072:SF136
type: RelationshipXref
id: PTHR24072:SF136
db: PANTHER Family
relationship type: By Homology

uniprot H2QJ75 1473
type: UnificationXref
id: H2QJ75
db: uniprot

uniprot P68034 1032
type: UnificationXref
id: P68034
db: uniprot

Actin-12
type: ProteinReference
xref: PTHR11937:SF434
xref: uniprot P53497 1011
organism: Arabidopsis thaliana

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1MKT3 1451
organism: Bos taurus

uniprot G3V8K2 338
type: UnificationXref
id: G3V8K2
db: uniprot

Actin-4
type: ProteinReference
xref: PTHR11937:SF438
xref: uniprot P53494 1010
organism: Arabidopsis thaliana

Actin-7
type: ProteinReference
xref: uniprot P53492 1009
xref: PTHR11937:SF483
organism: Arabidopsis thaliana

PI3K
type: ProteinReference
xref: P00868
standard name: Phosphatidylinositol 3-kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphoinositide 3-kinase Synonym: PI3K Accession: P00868
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.PI3K
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol 3-kinase 3
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: AGAP000018-PA
member entity reference: PI-3 kinase
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
member entity reference: Uncharacterized protein
member entity reference: PIK3CG isoform 1
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
member entity reference: Phosphatidylinositol 3-kinase 1
member entity reference: Phosphatidylinositol 3-kinase 2

uniprot A8WS37 908
type: UnificationXref
id: A8WS37
db: uniprot

uniprot H2QC97 1306
type: UnificationXref
id: H2QC97
db: uniprot

uniprot P48973 847
type: UnificationXref
id: P48973
db: uniprot

uniprot F6ZGX8 1399
type: UnificationXref
id: F6ZGX8
db: uniprot

Myosin IIIB
type: ProteinReference
xref: PTHR46256:SF1
xref: uniprot H2QZG8 1310
organism: Pan troglodytes

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
type: ProteinReference
xref: uniprot P10688 1487
organism: Rattus norvegicus

uniprot P50231 850
type: UnificationXref
id: P50231
db: uniprot

Cytokine receptor
type: Protein
entity reference: Cytokine receptor
feature: ACTIVE 46

Actin, cytoplasmic type 5
type: ProteinReference
xref: uniprot P53478 1008
xref: PTHR11937:SF168
organism: Gallus gallus

EMC
type: ProteinReference
xref: P00863
standard name: ExtraCellular matrix protein
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.EMC
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: ExtraCellular matrix protein Synonym: Synonym not specified Accession: P00863
member entity reference: Collagen alpha-3(VI) chain
member entity reference: Collagen type VI alpha 1 chain
member entity reference: Collagen type VI alpha 2 chain
member entity reference: COL12A1 isoform 1
member entity reference: von Willebrand factor A domain-containing protein 2
member entity reference: Collagen alpha-2(VI) chain
member entity reference: COL20A1 isoform 3
member entity reference: Collagen alpha-1(XII) chain
member entity reference: Uncharacterized protein
member entity reference: Collagen type XIV alpha 1 chain
member entity reference: Collagen alpha-6(VI) chain
member entity reference: Collagen alpha-1(XIV) chain
member entity reference: Integrin subunit alpha 2
member entity reference: Collagen alpha-1(VI) chain
member entity reference: von Willebrand factor
member entity reference: Collagen type VI alpha 3 chain
member entity reference: Integrin alpha-2
member entity reference: VWF isoform 2
member entity reference: Collagen, type VI, alpha 3
member entity reference: Collagen alpha-1(XX) chain
member entity reference: COL14A1 isoform 4

uniprot F6UQ33 788
type: UnificationXref
id: F6UQ33
db: uniprot

Transforming protein RhoA
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot Q9QUI0 1127
organism: Mus musculus

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 348

GTP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 50

uniprot P70658 749
type: UnificationXref
id: P70658
db: uniprot

uniprot F6QWB7 960
type: UnificationXref
id: F6QWB7
db: uniprot

uniprot Q62829 420
type: UnificationXref
id: Q62829
db: uniprot

Cyclooxygenase 2
type: ProteinReference
xref: uniprot Q8SPQ9 540
xref: PTHR11903:SF8
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 374
xref: PTHR13809:SF5
organism: Mus musculus

uniprot A0A0D1DMT3 886
type: UnificationXref
id: A0A0D1DMT3
db: uniprot

C-C motif chemokine 5
type: ProteinReference
xref: uniprot Q8HYQ1 871
xref: PTHR12015:SF170
organism: Macaca mulatta

Phosphatidylinositol 3-kinase 3
type: ProteinReference
xref: uniprot P54675 1387
xref: PTHR10048:SF48
organism: Dictyostelium discoideum

uniprot C3ZHN4 941
type: UnificationXref
id: C3ZHN4
db: uniprot

Phosphatidylinositol 3-kinase 2
type: ProteinReference
xref: uniprot P54674 1386
organism: Dictyostelium discoideum

Phosphatidylinositol 3-kinase 1
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot P54673 1385
organism: Dictyostelium discoideum

uniprot P11055 1318
type: UnificationXref
id: P11055
db: uniprot

uniprot H2QC99 1308
type: UnificationXref
id: H2QC99
db: uniprot

Actin, cytoskeletal 3A
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P53474 1007
organism: Strongylocentrotus purpuratus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: uniprot P10686 1485
xref: PTHR10336:SF173
organism: Rattus norvegicus

uniprot Q9BRC7 1525
type: UnificationXref
id: Q9BRC7
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot P10687 1486
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q90Z40 375
xref: PTHR13809:SF11
organism: Danio rerio

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PYK2-RIGHT__PYK2-_r18
controller: Gbetagamma

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot B3RKR4 921
organism: Trichoplax adhaerens

uniprot P40793 223
type: UnificationXref
id: P40793
db: uniprot

Interferon alpha/beta receptor 1
type: ProteinReference
xref: PTHR20859:SF54
xref: uniprot Q04790 1243
organism: Bos taurus

uniprot F7GT47 546
type: UnificationXref
id: F7GT47
db: uniprot

Collagen alpha-1(XIV) chain
type: ProteinReference
xref: PTHR24020:SF15
xref: uniprot Q05707 1218
organism: Homo sapiens

Formyl peptide receptor-related sequence 7
type: ProteinReference
xref: uniprot Q71MR7 768
organism: Mus musculus

uniprot F7E2P1 1469
type: UnificationXref
id: F7E2P1
db: uniprot

PTHR24023:SF917
type: RelationshipXref
id: PTHR24023:SF917
db: PANTHER Family
relationship type: By Homology

C-C motif chemokine 21
type: ProteinReference
xref: PTHR12015:SF72
xref: uniprot Q8HYP5 870
organism: Macaca mulatta

COL20A1 isoform 3
type: ProteinReference
xref: PTHR24020:SF39
xref: uniprot H2R3F1 1208
organism: Pan troglodytes

uniprot Q5M824 1237
type: UnificationXref
id: Q5M824
db: uniprot

Neither inactivation nor afterpotential protein C
type: ProteinReference
xref: uniprot P10676 1317
organism: Drosophila melanogaster

uniprot F6PR50 1228
type: UnificationXref
id: F6PR50
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3YKS6 937
organism: Branchiostoma floridae

uniprot F7A632 1130
type: UnificationXref
id: F7A632
db: uniprot

uniprot Q63644 1693
type: UnificationXref
id: Q63644
db: uniprot

uniprot O55197 704
type: UnificationXref
id: O55197
db: uniprot

uniprot P80075 858
type: UnificationXref
id: P80075
db: uniprot

uniprot O43306 471
type: UnificationXref
id: O43306
db: uniprot

uniprot E2RT60 641
type: UnificationXref
id: E2RT60
db: uniprot

uniprot H2QB68 810
type: UnificationXref
id: H2QB68
db: uniprot

G protein subunit beta 3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot H2R3A6 343
organism: Pan troglodytes

Actin, beta-like 2
type: ProteinReference
xref: uniprot D3ZRN3 944
xref: PTHR11937:SF168
organism: Rattus norvegicus

uniprot F6RH86 1289
type: UnificationXref
id: F6RH86
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: uniprot F7A472 91
organism: Xenopus tropicalis

Actin, putative (Fragment)
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot B7PBG2 925
organism: Ixodes scapularis

uniprot Q00722 1498
type: UnificationXref
id: Q00722
db: uniprot

uniprot E1C8Y3 1561
type: UnificationXref
id: E1C8Y3
db: uniprot

uniprot P21278 28
type: UnificationXref
id: P21278
db: uniprot

uniprot F1P1X4 487
type: UnificationXref
id: F1P1X4
db: uniprot

uniprot P20399 1005
type: UnificationXref
id: P20399
db: uniprot

uniprot P34099 1167
type: UnificationXref
id: P34099
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7BAS2 402
xref: PTHR48015:SF30
organism: Ornithorhynchus anatinus

uniprot Q15147 1502
type: UnificationXref
id: Q15147
db: uniprot

Myosin-2
type: ProteinReference
xref: PTHR45615:SF39
xref: uniprot Q9UKX2 1351
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot Q8CIH5 1516
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2U980 1394
organism: Gallus gallus

Myosin-13
type: ProteinReference
xref: PTHR45615:SF44
xref: uniprot Q9UKX3 1352
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF446
xref: uniprot C3YC50 936
organism: Branchiostoma floridae

SOCS
type: Protein
entity reference: SOCS
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR24072:SF100
type: RelationshipXref
id: PTHR24072:SF100
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Complex__CHKR_CHK_-RIGHT__Complex__CHKR_CHK_-_re70
control type: ACTIVATION
controller: GPRK

Candida albicans
type: BioSource
xref: ncbitaxon 237561 212

ncbitaxon 44689 217
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot Q6RUV5 250
type: UnificationXref
id: Q6RUV5
db: uniprot

Myosin heavy chain 6
type: ProteinReference
xref: PTHR45615:SF11
xref: uniprot A0A2I3TIW8 1256
organism: Pan troglodytes

C-X-C chemokine receptor type 1
type: ProteinReference
xref: PTHR10489:SF916
xref: uniprot H2QJE0 685
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLCbetagamma-RIGHT__PLCbetagamma-_r21
controller: Ras

STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1900
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1901
left: PKC
interaction type: STATE_TRANSITION
right: PKC

C-C motif chemokine 27
type: ProteinReference
xref: uniprot Q9Y4X3 881
xref: PTHR17502:SF4
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot A0A1D5Q4D0 1432
organism: Macaca mulatta

Ras homolog family member C
type: ProteinReference
xref: uniprot A0A0G2K6E0 1115
xref: PTHR24072:SF100
organism: Rattus norvegicus

SHC-transforming protein 1
type: ProteinReference
xref: uniprot P98083 1235
xref: PTHR10337:SF2
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot E2RJX4 51
organism: Canis lupus familiaris

Pro-inflammatory anti-apoptotic genes
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

B-cell lymphoma 3 protein homolog
type: ProteinReference
xref: uniprot Q9Z2F6 1114
organism: Mus musculus

uniprot P01116 1404
type: UnificationXref
id: P01116
db: uniprot

uniprot F7HLC7 1373
type: UnificationXref
id: F7HLC7
db: uniprot

uniprot Q23260 1653
type: UnificationXref
id: Q23260
db: uniprot

uniprot Q8K394 1517
type: UnificationXref
id: Q8K394
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A7F3M0 263
xref: PTHR24055:SF158
organism: Sclerotinia sclerotiorum

Uncharacterized protein
type: ProteinReference
xref: PTHR24020:SF15
xref: uniprot F7HQD8 1202
organism: Macaca mulatta

uniprot F6X9W7 457
type: UnificationXref
id: F6X9W7
db: uniprot

Prostaglandin G/H synthase 2
type: ProteinReference
xref: uniprot Q05769 538
xref: PTHR11903:SF8
organism: Mus musculus

Serine/threonine-protein kinase PAK 6
type: ProteinReference
xref: uniprot Q3ULB5 418
organism: Mus musculus

MAPK
type: Protein
entity reference: MAPK
feature: MAPK s162 a236 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Protein kinase C
type: ProteinReference
xref: uniprot A0A3Q1MSP9 119
xref: PTHR24356:SF170
organism: Bos taurus

uniprot P50146 105
type: UnificationXref
id: P50146
db: uniprot

uniprot O70167 1379
type: UnificationXref
id: O70167
db: uniprot

C-C motif chemokine 3-like 1
type: ProteinReference
xref: uniprot P16619 841
organism: Homo sapiens

uniprot O23236 275
type: UnificationXref
id: O23236
db: uniprot

uniprot P01579 1658
type: UnificationXref
id: P01579
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot H2KNE6 980
organism: Phaeosphaeria nodorum

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q1K5B4 1615
organism: Neurospora crassa

uniprot F6X9N6 1572
type: UnificationXref
id: F6X9N6
db: uniprot

uniprot P16520 349
type: UnificationXref
id: P16520
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot Q9WVR3 455
organism: Rattus norvegicus

uniprot P61073 748
type: UnificationXref
id: P61073
db: uniprot

uniprot F6ZKL2 1466
type: UnificationXref
id: F6ZKL2
db: uniprot

ncbitaxon 54126 209
type: UnificationXref
id: 54126
db: ncbitaxon

uniprot F6XWE8 326
type: UnificationXref
id: F6XWE8
db: uniprot

uniprot H2QXB9 1152
type: UnificationXref
id: H2QXB9
db: uniprot

Phospholipase A2
type: ProteinReference
evidence: Evidence 786
xref: PTHR10728:SF13
xref: uniprot H2Q0T0 792
organism: Pan troglodytes

uniprot Q9R117 550
type: UnificationXref
id: Q9R117
db: uniprot

Actin, alpha skeletal muscle
type: ProteinReference
xref: uniprot P68134 1035
xref: PTHR11937:SF193
organism: Mus musculus

Actin, alpha skeletal muscle
type: ProteinReference
xref: uniprot P68133 1034
xref: PTHR11937:SF193
organism: Homo sapiens

Actin, alpha skeletal muscle
type: ProteinReference
xref: uniprot P68136 1036
xref: PTHR11937:SF193
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION_LEFT__IkappaB-_NFkappaB-RIGHT__Complex__NFkappaB_IkappaB_-_re67
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re67 1876
participant stoichiometry: PARTICIPANT STOICHIOMETRY re67 1878
participant stoichiometry: PARTICIPANT STOICHIOMETRY re67 1877
left: NFkappaB
left: IkappaB
interaction type: HETERODIMER_ASSOCIATION
right: Complex (NFkappaB/IkappaB)

Actin, alpha skeletal muscle
type: ProteinReference
xref: uniprot P68138 1037
xref: PTHR11937:SF193
organism: Bos taurus

Small-inducible cytokine A27
type: ProteinReference
xref: PTHR17502:SF4
xref: uniprot F7H9Z6 809
organism: Macaca mulatta

Actin, alpha skeletal muscle
type: ProteinReference
xref: uniprot P68139 1038
xref: PTHR11937:SF193
organism: Gallus gallus

uniprot E2QTG4 629
type: UnificationXref
id: E2QTG4
db: uniprot

PKA
type: ProteinReference
xref: P00862
standard name: Protein kinase A
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.PKA
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein kinase A Synonym: PKA Accession: P00862
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
member entity reference: cAMP-dependent protein kinase type 3
member entity reference: cAMP-dependent protein kinase catalytic subunit PRKX
member entity reference: cAMP-dependent protein kinase catalytic subunit
member entity reference: Uncharacterized protein
member entity reference: Protein kinase A catalytic subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha
member entity reference: AGAP008039-PA (Fragment)
member entity reference: AGAP011840-PA (Fragment)
member entity reference: Protein kinase cAMP-activated catalytic subunit alpha
member entity reference: cAMP-dependent protein kinase type 1
member entity reference: cAMP-dependent protein kinase type 2
member entity reference: cAMP-dependent protein kinase catalytic subunit beta isoform 1
member entity reference: cAMP-dependent protein kinase catalytic subunit beta
member entity reference: PRKACB isoform 3
member entity reference: cAMP-dependent protein kinase, catalytic subunit-like
member entity reference: Protein serine/threonine kinase, putative
member entity reference: Protein kinase cAMP-activated catalytic subunit beta
member entity reference: Protein kinase, X-linked
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
member entity reference: cAMP-dependent protein kinase catalytic subunit 1
member entity reference: AGAP001384-PA
member entity reference: cAMP-dependent protein kinase catalytic subunit gamma
member entity reference: cAMP-dependent protein kinase catalytic subunit TPK2
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta
member entity reference: PRKACG isoform 1
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha isoform 1

ncbitaxon 7165 74
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot D3ZUE4 1669
type: UnificationXref
id: D3ZUE4
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot B5DF62 385
organism: Rattus norvegicus

uniprot Q6GL60 248
type: UnificationXref
id: Q6GL60
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PAK-RIGHT__PAK-_r36
controller: Cdc42

Serine/threonine-protein kinase PAK 2
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot Q64303 421
organism: Rattus norvegicus

PTHR23220:SF23
type: RelationshipXref
id: PTHR23220:SF23
db: PANTHER Family
relationship type: By Homology

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63001 230
organism: Mus musculus

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63000 229
organism: Homo sapiens

uniprot O00574 695
type: UnificationXref
id: O00574
db: uniprot

Myosin IIIA
type: ProteinReference
xref: PTHR46256:SF4
xref: uniprot F1RAJ1 1287
organism: Danio rerio

Giardia intestinalis
type: BioSource
xref: ncbitaxon 184922 904

C-C chemokine receptor type 5
type: ProteinReference
xref: uniprot P56440 744
organism: Pan troglodytes

GO GO:0005634 2
type: UnificationXref
id: GO:0005634
db: GO

uniprot Q02156 1139
type: UnificationXref
id: Q02156
db: uniprot

Raf-1
type: Protein
entity reference: Raf-1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q7JP68 1179
type: UnificationXref
id: Q7JP68
db: uniprot

uniprot Q9UBI6 378
type: UnificationXref
id: Q9UBI6
db: uniprot

PRKACB isoform 3
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot H2R1G3 1153
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q7QK56 73
xref: PTHR24356:SF333
organism: Anopheles gambiae

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot A0A2I3T9Y4 47
organism: Pan troglodytes

EMC
type: Protein
entity reference: EMC
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF325
xref: uniprot F7GY91 205
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XUU0 969
xref: PTHR11937:SF240
organism: Monodelphis domestica

Myosin, heavy polypeptide 1.2, skeletal muscle
type: ProteinReference
xref: uniprot B8A561 1266
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r36 1843
type: Stoichiometry
physical entity: PAK
stoichiometric coefficient: 1.0

Gbetagamma
type: Protein
entity reference: Gbetagamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa9 1731
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r36 1842
type: Stoichiometry
physical entity: PAK
stoichiometric coefficient: 1.0

uniprot Q7T3D3 116
type: UnificationXref
id: Q7T3D3
db: uniprot

N-formyl peptide receptor 3 (Fragment)
type: ProteinReference
xref: uniprot P79191 752
organism: Macaca mulatta

uniprot Q9QZB0 179
type: UnificationXref
id: Q9QZB0
db: uniprot

uniprot F6YVE7 1673
type: UnificationXref
id: F6YVE7
db: uniprot

Protein kinase cAMP-activated catalytic subunit beta
type: ProteinReference
xref: uniprot F6T0T9 1146
xref: PTHR24353:SF116
organism: Xenopus tropicalis

uniprot P13501 838
type: UnificationXref
id: P13501
db: uniprot

uniprot Q27991 1333
type: UnificationXref
id: Q27991
db: uniprot

Sos
type: ProteinReference
xref: P00850
standard name: Son of sevenless
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Son of Sevenless Synonym: Synonym not specified Accession: P00850
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.Sos
member entity reference: SOS Ras/Rac guanine nucleotide exchange factor 1
member entity reference: Son of sevenless homolog 1

uniprot P15988 1214
type: UnificationXref
id: P15988
db: uniprot

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot P08134 1121
organism: Homo sapiens

PI3K
type: Protein
entity reference: PI3K
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q3SZ98 370
type: UnificationXref
id: Q3SZ98
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: uniprot O77627 437
xref: PTHR11462:SF8
organism: Bos taurus

uniprot O00585 822
type: UnificationXref
id: O00585
db: uniprot

fMet-Leu-Phe receptor (Fragment)
type: ProteinReference
xref: uniprot P79189 751
xref: PTHR24225:SF15
organism: Macaca mulatta

C5a anaphylatoxin chemotactic receptor 1 (Fragment)
type: ProteinReference
xref: PTHR24225:SF29
xref: uniprot P79188 750
organism: Macaca mulatta

uniprot A8WS33 907
type: UnificationXref
id: A8WS33
db: uniprot

uniprot A0JP99 384
type: UnificationXref
id: A0JP99
db: uniprot

uniprot F1MRY8 671
type: UnificationXref
id: F1MRY8
db: uniprot

IKK
type: Protein
entity reference: IKK
feature: IKK s85 a130 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7GAZ2 129
type: UnificationXref
id: F7GAZ2
db: uniprot

eco ECO:0000304 50
type: UnificationXref
id: ECO:0000304
db: eco

Gnai3 protein
type: ProteinReference
xref: uniprot A9JTC8 85
organism: Danio rerio

uniprot E9FXV8 948
type: UnificationXref
id: E9FXV8
db: uniprot

uniprot Q9BPX5 1631
type: UnificationXref
id: Q9BPX5
db: uniprot

Myosin, heavy polypeptide 1.1, skeletal muscle
type: ProteinReference
xref: uniprot B8A568 1267
organism: Danio rerio

uniprot O88537 707
type: UnificationXref
id: O88537
db: uniprot

Ras-related protein R-Ras
type: ProteinReference
xref: uniprot P10301 1406
xref: PTHR24070:SF245
organism: Homo sapiens

uniprot P86792 861
type: UnificationXref
id: P86792
db: uniprot

Myosin, heavy polypeptide 1.3, skeletal muscle
type: ProteinReference
xref: uniprot B8A569 1268
organism: Danio rerio

Transcription factor jun-B
type: ProteinReference
xref: PTHR11462:SF37
xref: uniprot P24898 447
organism: Rattus norvegicus

uniprot Q17QZ0 417
type: UnificationXref
id: Q17QZ0
db: uniprot

Cytokine receptor s32 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cytokine receptor
stoichiometric coefficient: 2.0

PKCzeta
type: ProteinReference
xref: P00829
standard name: Protein kinase C, zeta
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.PKC_zeta_
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein Kinase C zeta Synonym: Synonym not specified Accession: P00829
member entity reference: Protein kinase C
member entity reference: Protein kinase C zeta type

uniprot Q80SZ7 374
type: UnificationXref
id: Q80SZ7
db: uniprot

Interferon gamma
type: ProteinReference
xref: uniprot P49708 1663
xref: PTHR11419:SF0
organism: Gallus gallus

PI3K
type: Protein
entity reference: PI3K
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1Q376 1458
organism: Canis lupus familiaris

Interferon alpha/beta receptor 1
type: ProteinReference
xref: PTHR20859:SF54
xref: uniprot P17181 1241
organism: Homo sapiens

Actin-related protein 2/3 complex subunit 5-like protein
type: ProteinReference
xref: uniprot Q9BPX5 1631
xref: PTHR12644:SF2
organism: Homo sapiens

uniprot P16054 1137
type: UnificationXref
id: P16054
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q9U1E8 1084
organism: Leishmania major

uniprot Q9Z121 882
type: UnificationXref
id: Q9Z121
db: uniprot

Galphai/q
type: ProteinReference
xref: P00873
standard name: Gi/q-protein, alpha subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.G_alpha__sub_i/q
comment: ENTITY_REFERENCE_NOTES=
member entity reference: G protein subunit alpha o1
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)
member entity reference: Gnai3 protein
member entity reference: Guanine nucleotide-binding protein subunit alpha-11
member entity reference: Guanine nucleotide-binding protein subunit alpha-14
member entity reference: Guanine nucleotide-binding protein G(k) subunit alpha
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein (G protein), q polypeptide
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)
member entity reference: Guanine nucleotide-binding protein G(q) subunit alpha
member entity reference: G protein subunit alpha i1
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
member entity reference: G protein subunit alpha 14
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
member entity reference: G protein subunit alpha q
member entity reference: Guanine nucleotide-binding protein G(K) subunit alpha
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 14
member entity reference: Guanine nucleotide-binding protein alpha-1 subunit
member entity reference: Guanine nucleotide-binding protein alpha subunit
member entity reference: Guanine nucleotide-binding protein G(O) subunit alpha isoform a
member entity reference: Guanine nucleotide-binding protein subunit alpha
member entity reference: Guanine nucleotide-binding protein subunit alpha-15
member entity reference: G-alpha subunit
member entity reference: Guanine nucleotide-binding protein G(o) subunit alpha
member entity reference: G protein subunit alpha i3
member entity reference: Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3

uniprot P13542 1324
type: UnificationXref
id: P13542
db: uniprot

Suppressor of cytokine signaling 4
type: ProteinReference
xref: uniprot F6YVE7 1673
xref: PTHR10155:SF21
organism: Macaca mulatta

uniprot G5EBV3 207
type: UnificationXref
id: G5EBV3
db: uniprot

uniprot K7C8Z4 1482
type: UnificationXref
id: K7C8Z4
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 10

uniprot O54928 1683
type: UnificationXref
id: O54928
db: uniprot

Serine/threonine-protein kinase PAK 2
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot Q8CIN4 425
organism: Mus musculus

uniprot A0A3Q2U0G2 1442
type: UnificationXref
id: A0A3Q2U0G2
db: uniprot

IkappaB s86 a132 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ncbitaxon 5722 892
type: UnificationXref
id: 5722
db: ncbitaxon

C-C motif chemokine receptor 2
type: ProteinReference
xref: uniprot A0A2J8PAG2 661
organism: Pan troglodytes

uniprot E9GNI4 1145
type: UnificationXref
id: E9GNI4
db: uniprot

uniprot P63218 366
type: UnificationXref
id: P63218
db: uniprot

C-C chemokine receptor type 8
type: ProteinReference
xref: PTHR10489:SF627
xref: uniprot P56484 746
organism: Mus musculus

uniprot Q8MJ44 1184
type: UnificationXref
id: Q8MJ44
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P68182 1171
organism: Rattus norvegicus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P68181 1170
organism: Mus musculus

C-C chemokine receptor type 3
type: ProteinReference
xref: uniprot P56483 745
xref: PTHR10489:SF649
organism: Macaca mulatta

uniprot H2QK55 1649
type: UnificationXref
id: H2QK55
db: uniprot

IkappaB s86 a132 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.25
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot P15153 213
type: UnificationXref
id: P15153
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PIP3-RIGHT__PIP2-_re73
controller: PTEN

STATE_TRANSITION_LEFT__IkappaB-RIGHT__a296_degraded-_re69
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re69 1868
participant stoichiometry: PARTICIPANT STOICHIOMETRY re69 1869
left: IkappaB
interaction type: STATE_TRANSITION
right: a296_degraded

PTEN
type: Protein
entity reference: PTEN
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F1PVV7 1281
type: UnificationXref
id: F1PVV7
db: uniprot

uniprot Q05425 111
type: UnificationXref
id: Q05425
db: uniprot

uniprot H9FVU5 1376
type: UnificationXref
id: H9FVU5
db: uniprot

Transforming protein RhoA
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot P61585 1122
organism: Bos taurus

uniprot Q28003 759
type: UnificationXref
id: Q28003
db: uniprot

Transforming protein RhoA
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot P61586 1123
organism: Homo sapiens

Cytohesin-2
type: ProteinReference
xref: uniprot P63034 1544
xref: PTHR10663:SF343
organism: Mus musculus

Cytohesin-2
type: ProteinReference
xref: uniprot P63035 1545
xref: PTHR10663:SF343
organism: Rattus norvegicus

Protein kinase A catalytic subunit
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q27687 1172
organism: Leishmania major

Myosin-11
type: ProteinReference
xref: PTHR45615:SF23
xref: uniprot P35749 1327
organism: Homo sapiens

uniprot A0A1D5RJ31 1548
type: UnificationXref
id: A0A1D5RJ31
db: uniprot

uniprot F7D8G7 1675
type: UnificationXref
id: F7D8G7
db: uniprot

uniprot Q8CIN4 425
type: UnificationXref
id: Q8CIN4
db: uniprot

PARTICIPANT STOICHIOMETRY r78 1805
type: Stoichiometry
physical entity: AP-1
stoichiometric coefficient: 1.0

uniprot E9GYE9 194
type: UnificationXref
id: E9GYE9
db: uniprot

uniprot Q03366 864
type: UnificationXref
id: Q03366
db: uniprot

PARTICIPANT STOICHIOMETRY r78 1804
type: Stoichiometry
physical entity: AP-1
stoichiometric coefficient: 1.0

uniprot Q1ECJ7 1613
type: UnificationXref
id: Q1ECJ7
db: uniprot

Inflammation mediated by chemokine and cytokine signaling pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r76
pathway component: UNKNOWN_TRANSITION_LEFT__Complex__Galphai_q__GTP_-RIGHT__Complex__Galphaq_GTP_-_r7
pathway component: STATE_TRANSITION_LEFT__AP_1-RIGHT__AP_1-_r78
pathway component: STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_r31
pathway component: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r74
pathway component: STATE_TRANSITION_LEFT__MLCK-RIGHT__MLCK-_r34
pathway component: STATE_TRANSITION_LEFT__Plasma_membrane_phospholipid-RIGHT__Arachidonic_acid-_r81
pathway component: STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r75
pathway component: HETERODIMER_ASSOCIATION_LEFT__Sos-_Shc-_Grb-RIGHT__Complex__Shc_Sos__Grb_-_r69
pathway component: STATE_TRANSITION_LEFT__CaMK-RIGHT__CaMK-_r26
pathway component: HETERODIMER_ASSOCIATION_LEFT__IkappaB-_NFkappaB-RIGHT__Complex__NFkappaB_IkappaB_-_re67
pathway component: STATE_TRANSITION_LEFT__PYK2-RIGHT__PYK2-_r18
pathway component: STATE_TRANSITION_LEFT__PAK-RIGHT__PAK-_r36
pathway component: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r23
pathway component: HETERODIMER_ASSOCIATION_LEFT__Cytokine_receptor-_IL2-RIGHT__Complex__Cytokine_receptor_IL2_-_r86
pathway component: HETERODIMER_ASSOCIATION_LEFT__Cytokine_receptor-_INFgamma-RIGHT__Complex__Cytokine_receptor_INFgamma_-_r57
pathway component: STATE_TRANSITION_LEFT__PIP2-RIGHT__DAG-_IP3-_r22
pathway component: TRANSPORT_LEFT__NFkappaB-RIGHT__NFkappaB-_r48
pathway component: STATE_TRANSITION_LEFT__GEF-RIGHT__GEF-_r30
pathway component: DISSOCIATION_LEFT__Complex__Cytokine_receptor_IL2__STAT_JAK__JAK_-RIGHT__Complex__Cytokine_receptor_JAK__JAK_IL2_-_STAT-_r88
pathway component: STATE_TRANSITION_LEFT__Cdc42-RIGHT__Cdc42-_r33
pathway component: STATE_TRANSITION_LEFT__PIP2-RIGHT__PIP3-_r28
pathway component: STATE_TRANSITION_LEFT__Arachidonic_acid-RIGHT__Prostaglandin-_r79
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r10
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Cytokine_receptor_JAK__JAK_INFgamma_-_STAT-RIGHT__Complex__Cytokine_receptor_JAK__JAK_STAT__INFgamma_-_r60
pathway component: STATE_TRANSITION_LEFT__PIP3-RIGHT__PIP2-_re73
pathway component: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r24
pathway component: DISSOCIATION_LEFT__Complex__CHKR_CHK__Galphai_q__GDP_Gbetagamma_-_GTP-RIGHT__Complex__Galphai_q__GTP_-_Complex__CHKR_CHK_-_GDP-_Gbetagamma-_r5
pathway component: STATE_TRANSITION_LEFT__IkappaB-RIGHT__IkappaB-_re68
pathway component: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r32
pathway component: TRANSPORT_LEFT__STAT-RIGHT__STAT-_r63
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__CHKR_Galphai__q_GDP__Gbetagamma_-_CHK-RIGHT__Complex__CHKR_CHK__Galphai_q__GDP_Gbetagamma_-_r2
pathway component: STATE_TRANSITION_LEFT__Arachidonic_acid-RIGHT__Leukotriene-_r82
pathway component: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_r8
pathway component: TRANSCRIPTION_LEFT__Pro_inflammatory_genes-RIGHT__pro_inflammatory_genes-_re72
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Cytokine_receptor_INFgamma_-_JAK-RIGHT__Complex__Cytokine_receptor_JAK__JAK_INFgamma_-_r58
pathway component: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r27
pathway component: PHYSICAL_STIMULATION
pathway component: TRANSCRIPTION_LEFT__Pro_inflammatory_anti_apoptotic_genes-RIGHT__pro_inflammatory_anti_apoptotic_genes-_re71
pathway component: STATE_TRANSITION_LEFT__Complex__CHKR_CHK_-RIGHT__Complex__CHKR_CHK_-_re70
pathway component: DISSOCIATION_LEFT__Complex__Cytokine_receptor_JAK__JAK_STAT__INFgamma_-RIGHT__Complex__Cytokine_receptor_JAK__JAK_INFgamma_-_STAT-_r62
pathway component: STATE_TRANSITION_LEFT__Myosin-RIGHT__Myosin-_r38
pathway component: STATE_TRANSITION_LEFT__NFAT-RIGHT__NFAT-_r51
pathway component: UNKNOWN_TRANSITION_LEFT__Complex__Galphai_q__GTP_-RIGHT__Complex__Galphai_GTP_-_r6
pathway component: STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_r29
pathway component: STATE_TRANSITION_LEFT__SrcPTK-RIGHT__SrcPTK-_r11
pathway component: STATE_TRANSITION_LEFT__PDK1-RIGHT__PDK1-_r42
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_r9
pathway component: STATE_TRANSITION_LEFT__JAK-RIGHT__JAK-_r54
pathway component: STATE_TRANSITION_LEFT__ROCK-RIGHT__ROCK-_r35
pathway component: STATE_TRANSITION_LEFT__MAPK-RIGHT__MAPK-_r77
pathway component: STATE_TRANSITION_LEFT__PKCzeta-RIGHT__PKCzeta-_r40
pathway component: STATE_TRANSITION_LEFT__Arp2_3-RIGHT__Arp2_3-_r37
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Cytokine_receptor_IL2_-_STAT-_JAK-RIGHT__Complex__Cytokine_receptor_IL2__STAT_JAK__JAK_-_r87
pathway component: HETERODIMER_ASSOCIATION_LEFT__EMC-_Integrin-RIGHT__Complex__Integrin_EMC_-_r41
pathway component: STATE_TRANSITION_LEFT__IkappaB-RIGHT__IkappaB-_r46
pathway component: STATE_TRANSITION_LEFT__IKK-RIGHT__IKK-_r45
pathway component: STATE_TRANSITION_LEFT__IkappaB-RIGHT__a296_degraded-_re69
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r25
pathway component: STATE_TRANSITION_LEFT__F_actin-RIGHT__F_actin-_r39
pathway component: STATE_TRANSITION_LEFT__PLCbetagamma-RIGHT__PLCbetagamma-_r21
xref: PANTHER Pathway P00031 1
comment: MODEL_NOTES=Panther Pathway: P00031 Upon binding to a family of G-protein coupled seven-transmembrane receptors, chemokines (chemotactic cytokines) control and direct trafficking and migration of immune cells. This pathway illustrates chemokine-induced adhesion and migration of leukocytes resuling in the infiltration to the tissue and transcriptional activation enablingrecruitment of more leukocytes. Thus inhibiting specific chemokines and receptors could prevent the excessive recruitment of leukocytes to sites of inflammation. Medline=11905818 Medline=12049209 PMID: 11905818 PMID: 12049209

uniprot Q9Z2F6 1114
type: UnificationXref
id: Q9Z2F6
db: uniprot

uniprot Q28024 368
type: UnificationXref
id: Q28024
db: uniprot

Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta
type: ProteinReference
xref: uniprot F6UQZ6 560
xref: PTHR24347:SF365
organism: Xenopus tropicalis

uniprot P68182 1171
type: UnificationXref
id: P68182
db: uniprot

STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_r31
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 1856
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 1857
left: Rho
interaction type: STATE_TRANSITION
right: Rho

uniprot A0A2A6CRA8 890
type: UnificationXref
id: A0A2A6CRA8
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot Q04970 1408
xref: PTHR24070:SF189
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot E2R9G5 313
organism: Canis lupus familiaris

Ras homolog family member C
type: ProteinReference
xref: uniprot A0A2I3S4I6 1116
xref: PTHR24072:SF100
organism: Pan troglodytes

Rac-like GTPase
type: ProteinReference
xref: uniprot G5EBV3 207
organism: Caenorhabditis elegans

Mitogen-activated protein kinase 11
type: ProteinReference
xref: PTHR24055:SF439
xref: uniprot Q9LMM5 304
organism: Arabidopsis thaliana

C-X-C motif chemokine
type: ProteinReference
xref: uniprot H2QPN4 813
xref: PTHR10179:SF38
organism: Pan troglodytes

Rho
type: ProteinReference
xref: P00860
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.Rho
comment: ENTITY_REFERENCE_NOTES=Long Name: Rho Synonym: Synonym not specified Accession: P00860
member entity reference: Uncharacterized protein
member entity reference: Rho-related GTP-binding protein RhoC
member entity reference: GTP-binding protein
member entity reference: Ras homolog family member C
member entity reference: Transforming protein RhoA
member entity reference: RHOA isoform 2

uniprot F1PSD3 804
type: UnificationXref
id: F1PSD3
db: uniprot

C-X-C motif chemokine
type: ProteinReference
xref: PTHR10179:SF43
xref: uniprot H2QPN6 814
organism: Pan troglodytes

uniprot P63078 359
type: UnificationXref
id: P63078
db: uniprot

IL2
type: Protein
entity reference: IL2
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot P60484 594
organism: Homo sapiens

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot P60483 593
xref: PTHR12305:SF81
organism: Canis lupus familiaris

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot F6W3Y0 399
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RIM7 88
organism: Monodelphis domestica

uniprot D3Z8L7 1396
type: UnificationXref
id: D3Z8L7
db: uniprot

Multifunctional fusion protein
type: ProteinReference
xref: PTHR10179:SF42
xref: uniprot H2QPN2 812
organism: Pan troglodytes

uniprot F6UQZ6 560
type: UnificationXref
id: F6UQZ6
db: uniprot

uniprot Q8SQB1 875
type: UnificationXref
id: Q8SQB1
db: uniprot

uniprot P11345 525
type: UnificationXref
id: P11345
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R2S3 312
xref: PTHR13809:SF8
organism: Canis lupus familiaris

uniprot P51675 732
type: UnificationXref
id: P51675
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: uniprot P18289 445
xref: PTHR11462:SF35
organism: Drosophila melanogaster

uniprot F6Y1M7 1293
type: UnificationXref
id: F6Y1M7
db: uniprot

uniprot P21279 31
type: UnificationXref
id: P21279
db: uniprot

uniprot A0A2J8QDF6 1440
type: UnificationXref
id: A0A2J8QDF6
db: uniprot

eco ECO:0000501 798
type: UnificationXref
id: ECO:0000501
db: eco

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 6

uniprot P16619 841
type: UnificationXref
id: P16619
db: uniprot

G protein subunit alpha 14
type: ProteinReference
xref: uniprot F7G1U7 22
organism: Monodelphis domestica

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P04627 521
organism: Mus musculus

PTHR11903:SF6
type: RelationshipXref
id: PTHR11903:SF6
db: PANTHER Family
relationship type: By Homology

PTHR11903:SF8
type: RelationshipXref
id: PTHR11903:SF8
db: PANTHER Family
relationship type: By Homology

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot Q9Y7J4 1644
xref: PTHR12391:SF0
organism: Schizosaccharomyces pombe

uniprot F1RAJ1 1287
type: UnificationXref
id: F1RAJ1
db: uniprot

uniprot E2RJB3 315
type: UnificationXref
id: E2RJB3
db: uniprot

PTHR10489:SF705
type: RelationshipXref
id: PTHR10489:SF705
db: PANTHER Family
relationship type: By Homology

uniprot H2QKY9 1238
type: UnificationXref
id: H2QKY9
db: uniprot

3-phosphoinositide dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot F1Q2Y3 147
organism: Canis lupus familiaris

Actin-1
type: ProteinReference
xref: uniprot Q10DV7 1046
xref: PTHR11937:SF469
organism: Oryza sativa

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 523
xref: PTHR44329:SF22
xref: uniprot P05625 522
organism: Gallus gallus

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05627 439
organism: Mus musculus

uniprot H2RB55 1476
type: UnificationXref
id: H2RB55
db: uniprot

uniprot Q39026 292
type: UnificationXref
id: Q39026
db: uniprot

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: PTHR12058:SF0
xref: uniprot Q9CVB6 1633
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot Q7K6A0 1180
organism: Plasmodium falciparum

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF15
xref: uniprot F7FY59 458
organism: Macaca mulatta

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot A8XW88 1144
xref: PTHR24353:SF117
organism: Caenorhabditis briggsae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLCbetagamma-RIGHT__PLCbetagamma-_r21
controller: Complex (Galphaq/GTP)

Leukotriene B4 receptor 2
type: ProteinReference
xref: uniprot Q9JJL9 775
xref: PTHR24230:SF8
organism: Mus musculus

uniprot P35354 536
type: UnificationXref
id: P35354
db: uniprot

PTHR10489:SF711
type: RelationshipXref
id: PTHR10489:SF711
db: PANTHER Family
relationship type: By Homology

uniprot F1MKT3 1451
type: UnificationXref
id: F1MKT3
db: uniprot

uniprot Q5I0L5 867
type: UnificationXref
id: Q5I0L5
db: uniprot

uniprot A0A1D5P0F4 1187
type: UnificationXref
id: A0A1D5P0F4
db: uniprot

uniprot H2QE24 983
type: UnificationXref
id: H2QE24
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_r29
controller: PI3K

uniprot E2R481 391
type: UnificationXref
id: E2R481
db: uniprot

Regulator of G-protein signaling 4
type: ProteinReference
xref: PTHR10845:SF184
xref: uniprot P49798 173
organism: Homo sapiens

Regulator of G-protein signaling 4
type: ProteinReference
xref: PTHR10845:SF184
xref: uniprot P49799 174
organism: Rattus norvegicus

uniprot O62305 567
type: UnificationXref
id: O62305
db: uniprot

PARTICIPANT STOICHIOMETRY r7 1788
type: Stoichiometry
physical entity: Complex (Galphai/q/ GTP)
stoichiometric coefficient: 1.0

ncbitaxon 9258 322
type: UnificationXref
id: 9258
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r7 1789
type: Stoichiometry
physical entity: Complex (Galphaq/GTP)
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: uniprot O35904 1378
xref: PTHR10048:SF35
organism: Mus musculus

uniprot Q6GL82 1623
type: UnificationXref
id: Q6GL82
db: uniprot

uniprot P60709 1015
type: UnificationXref
id: P60709
db: uniprot

uniprot F6Z395 630
type: UnificationXref
id: F6Z395
db: uniprot

uniprot J9P702 344
type: UnificationXref
id: J9P702
db: uniprot

Myosin
type: Protein
entity reference: Myosin
feature: Myosin s73 a111 rs1
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot Q01112 233
organism: Schizosaccharomyces pombe

uniprot Q80TL1 480
type: UnificationXref
id: Q80TL1
db: uniprot

Arachidonate 5-lipoxygenase-activating protein
type: ProteinReference
xref: uniprot Q148F2 143
xref: PTHR10250:SF2
organism: Bos taurus

PKA
type: Protein
entity reference: PKA
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Integrin beta-2
type: ProteinReference
xref: PTHR10082:SF15
xref: uniprot P11835 650
organism: Mus musculus

Puccinia graminis
type: BioSource
xref: ncbitaxon 418459 946

F-actin
type: ProteinReference
xref: P00858
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.F-actin
comment: ENTITY_REFERENCE_NOTES=Long Name: F-actin Synonym: Synonym not specified Accession: P00858
member entity reference: Actin
member entity reference: Predicted protein
member entity reference: Uncharacterized protein
member entity reference: Actin alpha 1, skeletal muscle a
member entity reference: Putative actin
member entity reference: Actin-like protein
member entity reference: Actin, cytoplasmic 2
member entity reference: Protein CBG23090
member entity reference: Actin-2
member entity reference: Actin, gamma 2, smooth muscle, enteric
member entity reference: Actin, cytoplasmic type 5
member entity reference: AGAP001676-PA
member entity reference: Actin, alpha skeletal muscle
member entity reference: Actin, alpha cardiac muscle 1
member entity reference: Actin-42A
member entity reference: Actin, gamma-enteric smooth muscle
member entity reference: actin, muscle-like
member entity reference: Actin 1
member entity reference: Actin related protein
member entity reference: Actin 7
member entity reference: Cytoplasmatic actin
member entity reference: Actin-like protein 53D
member entity reference: Putative actin-5
member entity reference: Putative actin-9
member entity reference: Putative actin-23
member entity reference: Protein CBG02162
member entity reference: Actin-7
member entity reference: Beta-actin-like protein 2
member entity reference: Protein CBG02161
member entity reference: Actin, gamma
member entity reference: Actin, cytoplasmic 1
member entity reference: Actin-87E
member entity reference: Actin-1
member entity reference: Actin, aortic smooth muscle

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P90623 1042
organism: Trichomonas vaginalis

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot D4A3T0 595
organism: Rattus norvegicus

uniprot E1C3P6 390
type: UnificationXref
id: E1C3P6
db: uniprot

uniprot P14097 839
type: UnificationXref
id: P14097
db: uniprot

PTHR10336:SF25
type: RelationshipXref
id: PTHR10336:SF25
db: PANTHER Family
relationship type: By Homology

PTHR23220:SF78
type: RelationshipXref
id: PTHR23220:SF78
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot Q9P286 427
type: UnificationXref
id: Q9P286
db: uniprot

uniprot A6QLA5 664
type: UnificationXref
id: A6QLA5
db: uniprot

uniprot Q8HYP5 870
type: UnificationXref
id: Q8HYP5
db: uniprot

uniprot P56440 744
type: UnificationXref
id: P56440
db: uniprot

uniprot Q8MIZ1 872
type: UnificationXref
id: Q8MIZ1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24020:SF29
xref: uniprot F1MKG2 1197
organism: Bos taurus

uniprot A0A1D5Q071 449
type: UnificationXref
id: A0A1D5Q071
db: uniprot

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot F7FPY5 1577
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF35
xref: uniprot A0A3Q1LVZ9 1257
organism: Bos taurus

uniprot P40376 1168
type: UnificationXref
id: P40376
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V6P8 337
xref: PTHR13809:SF9
organism: Rattus norvegicus

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot B2GV73 1558
xref: PTHR12391:SF1
organism: Rattus norvegicus

uniprot P61586 1123
type: UnificationXref
id: P61586
db: uniprot

uniprot A9JRY8 184
type: UnificationXref
id: A9JRY8
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Myosin-RIGHT__Myosin-_r38
controller: MLCK

PTHR23220:SF69
type: RelationshipXref
id: PTHR23220:SF69
db: PANTHER Family
relationship type: By Homology

uniprot Q6P549 454
type: UnificationXref
id: Q6P549
db: uniprot

uniprot A8XGW3 181
type: UnificationXref
id: A8XGW3
db: uniprot

PKA
type: Protein
entity reference: PKA
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r27
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 1879
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 1880
left: PI3K
interaction type: STATE_TRANSITION
right: PI3K

uniprot E2RJX4 51
type: UnificationXref
id: E2RJX4
db: uniprot

Fractalkine
type: ProteinReference
xref: PTHR12015:SF92
xref: uniprot P78423 855
organism: Homo sapiens

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: PTHR10709:SF2
xref: uniprot Q9SJW6 1637
organism: Arabidopsis thaliana

uniprot A0A2I3RXX2 1253
type: UnificationXref
id: A0A2I3RXX2
db: uniprot

uniprot Q9Z1E3 885
type: UnificationXref
id: Q9Z1E3
db: uniprot

PTHR10336:SF11
type: RelationshipXref
id: PTHR10336:SF11
db: PANTHER Family
relationship type: By Homology

PTHR10336:SF12
type: RelationshipXref
id: PTHR10336:SF12
db: PANTHER Family
relationship type: By Homology

Major actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P07830 993
organism: Dictyostelium discoideum

PTHR10336:SF10
type: RelationshipXref
id: PTHR10336:SF10
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot A0A2I3SHP7 1438
organism: Pan troglodytes

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot P15153 213
organism: Homo sapiens

uniprot P0DM42 996
type: UnificationXref
id: P0DM42
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5F3U4 150
xref: PTHR24356:SF163
organism: Gallus gallus

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 182

uniprot O14241 1586
type: UnificationXref
id: O14241
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 71

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A4B3 203
organism: Monodelphis domestica

uniprot P60712 1018
type: UnificationXref
id: P60712
db: uniprot

uniprot F7A4B3 203
type: UnificationXref
id: F7A4B3
db: uniprot

Actin-3
type: ProteinReference
xref: PTHR11937:SF421
xref: uniprot P07829 992
organism: Dictyostelium discoideum

Actin-18
type: ProteinReference
xref: uniprot P07828 991
xref: PTHR11937:SF421
organism: Dictyostelium discoideum

STAT s78 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot F7GL73 979
organism: Monodelphis domestica

uniprot F6R0F5 1288
type: UnificationXref
id: F6R0F5
db: uniprot

uniprot H2Q1A9 981
type: UnificationXref
id: H2Q1A9
db: uniprot

G protein subunit alpha i1
type: ProteinReference
xref: uniprot A0A2I3S4R3 81
organism: Pan troglodytes

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot P51432 1497
xref: PTHR10336:SF11
organism: Mus musculus

uniprot A0A2J8QY32 1357
type: UnificationXref
id: A0A2J8QY32
db: uniprot

uniprot F6VPY1 323
type: UnificationXref
id: F6VPY1
db: uniprot

C-X-C motif chemokine
type: ProteinReference
xref: PTHR10179:SF47
xref: uniprot H2QPQ2 815
organism: Pan troglodytes

uniprot E2R5G6 1397
type: UnificationXref
id: E2R5G6
db: uniprot

Son of sevenless homolog 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot Q07889 601
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7F580 334
xref: PTHR13809:SF5
organism: Macaca mulatta

uniprot H2PZA6 339
type: UnificationXref
id: H2PZA6
db: uniprot

Phosphoinositide phospholipase C 3
type: ProteinReference
xref: uniprot Q56W08 1509
organism: Arabidopsis thaliana

uniprot A8BV70 903
type: UnificationXref
id: A8BV70
db: uniprot

Actin, alpha 2, smooth muscle, aorta
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot F7F4W9 978
organism: Ornithorhynchus anatinus

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A7SCN8 900
organism: Nematostella vectensis

uniprot F6WN64 1571
type: UnificationXref
id: F6WN64
db: uniprot

PARTICIPANT STOICHIOMETRY r57 1888
type: Stoichiometry
physical entity: Complex (Cytokine receptor/INFgamma)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r57 1887
type: Stoichiometry
physical entity: INFgamma
stoichiometric coefficient: 1.0

PTHR23220:SF84
type: RelationshipXref
id: PTHR23220:SF84
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot E2R2N2 266
organism: Canis lupus familiaris

GTP-binding protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot O93467 1120
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r57 1886
type: Stoichiometry
physical entity: Cytokine receptor
stoichiometric coefficient: 1.0

C-C motif chemokine 21
type: ProteinReference
xref: PTHR12015:SF72
xref: uniprot O00585 822
organism: Homo sapiens

uniprot G5EAY4 206
type: UnificationXref
id: G5EAY4
db: uniprot

uniprot P34144 216
type: UnificationXref
id: P34144
db: uniprot

uniprot Q66JF0 44
type: UnificationXref
id: Q66JF0
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot A0A3Q1M0G8 383
organism: Bos taurus

uniprot O08565 697
type: UnificationXref
id: O08565
db: uniprot

Arachidonate 12-lipoxygenase, epidermal-type
type: ProteinReference
xref: PTHR11771:SF34
xref: uniprot D3ZQF9 126
organism: Rattus norvegicus

uniprot Q02759 142
type: UnificationXref
id: Q02759
db: uniprot

BCL3, transcription coactivator
type: ProteinReference
xref: uniprot D3ZQF8 1095
organism: Rattus norvegicus

Transcription factor RelB
type: ProteinReference
xref: uniprot Q01201 1106
organism: Homo sapiens

uniprot A0A1D5QLW6 1433
type: UnificationXref
id: A0A1D5QLW6
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot E1BE66 1360
organism: Bos taurus

uniprot Q8K3H5 1342
type: UnificationXref
id: Q8K3H5
db: uniprot

Adenylate cyclase type 6
type: ProteinReference
xref: PTHR45627:SF11
xref: uniprot Q03343 477
organism: Rattus norvegicus

C-C motif chemokine
type: ProteinReference
xref: PTHR12015:SF108
xref: uniprot Q8QG55 874
organism: Gallus gallus

PTHR24353:SF133
type: RelationshipXref
id: PTHR24353:SF133
db: PANTHER Family
relationship type: By Homology

PTHR11801:SF18
type: RelationshipXref
id: PTHR11801:SF18
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF137
type: RelationshipXref
id: PTHR24353:SF137
db: PANTHER Family
relationship type: By Homology

uniprot A8JAV1 905
type: UnificationXref
id: A8JAV1
db: uniprot

PTHR24353:SF135
type: RelationshipXref
id: PTHR24353:SF135
db: PANTHER Family
relationship type: By Homology

uniprot B2RYB8 637
type: UnificationXref
id: B2RYB8
db: uniprot

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q60823 72
xref: PTHR24356:SF176
organism: Mus musculus

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: uniprot F0Z6V2 1564
xref: PTHR22629:SF0
organism: Dictyostelium purpureum

uniprot G3V6P8 337
type: UnificationXref
id: G3V6P8
db: uniprot

PTHR23113:SF168
type: RelationshipXref
id: PTHR23113:SF168
db: PANTHER Family
relationship type: By Homology

uniprot P31750 66
type: UnificationXref
id: P31750
db: uniprot

PTHR10489:SF649
type: RelationshipXref
id: PTHR10489:SF649
db: PANTHER Family
relationship type: By Homology

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: uniprot Q148J6 1612
xref: PTHR22629:SF0
organism: Bos taurus

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot P11881 496
xref: PTHR13715:SF52
organism: Mus musculus

Actin-2
type: ProteinReference
xref: uniprot Q96292 1082
xref: PTHR11937:SF430
organism: Arabidopsis thaliana

uniprot A0A3Q1N7P8 482
type: UnificationXref
id: A0A3Q1N7P8
db: uniprot

uniprot P18872 104
type: UnificationXref
id: P18872
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZHU6 1295
xref: PTHR45615:SF2
organism: Macaca mulatta

uniprot P10147 832
type: UnificationXref
id: P10147
db: uniprot

uniprot Q62120 548
type: UnificationXref
id: Q62120
db: uniprot

MLCK
type: Protein
entity reference: MLCK
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Actin, cytoplasmic 2
type: ProteinReference
xref: uniprot Q5ZMQ2 1059
xref: PTHR11937:SF414
organism: Gallus gallus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot H2Q1D9 340
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6W548 324
xref: PTHR13809:SF6
organism: Macaca mulatta

STATE_TRANSITION_LEFT__PIP2-RIGHT__PIP3-_r28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 1875
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 1874
left: PIP2
interaction type: STATE_TRANSITION
right: PIP3

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot P52287 356
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot Q91UZ1 1521
xref: PTHR10336:SF106
organism: Mus musculus

uniprot P04899 98
type: UnificationXref
id: P04899
db: uniprot

uniprot E2RLH2 1117
type: UnificationXref
id: E2RLH2
db: uniprot

PARTICIPANT STOICHIOMETRY r76 1815
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r76 1816
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

C-C motif chemokine 7
type: ProteinReference
xref: PTHR12015:SF161
xref: uniprot Q03366 864
organism: Mus musculus

IkappaB s108 sa50 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A0A0G2K470 1186
type: UnificationXref
id: A0A0G2K470
db: uniprot

PTHR10489:SF671
type: RelationshipXref
id: PTHR10489:SF671
db: PANTHER Family
relationship type: By Homology

uniprot F1M324 1450
type: UnificationXref
id: F1M324
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PR50 1228
organism: Macaca mulatta

PTHR24353:SF128
type: RelationshipXref
id: PTHR24353:SF128
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3SHP7 1438
type: UnificationXref
id: A0A2I3SHP7
db: uniprot

C-X-C chemokine receptor type 6
type: ProteinReference
xref: PTHR10489:SF705
xref: uniprot O00574 695
organism: Homo sapiens

uniprot Q13177 415
type: UnificationXref
id: Q13177
db: uniprot

Collagen alpha-1(XII) chain
type: ProteinReference
xref: PTHR24020:SF17
xref: uniprot Q60847 1219
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G1K7 21
organism: Monodelphis domestica

uniprot P06765 830
type: UnificationXref
id: P06765
db: uniprot

GRB2-related adaptor protein
type: ProteinReference
xref: uniprot Q4KM68 585
xref: PTHR46037:SF2
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF421
xref: uniprot F0Z796 951
organism: Dictyostelium purpureum

PARTICIPANT STOICHIOMETRY r62 1861
type: Stoichiometry
physical entity: Complex (Cytokine receptor/JAK/ JAK/INFgamma)
stoichiometric coefficient: 1.0

uniprot P01581 1660
type: UnificationXref
id: P01581
db: uniprot

PARTICIPANT STOICHIOMETRY r62 1862
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r62 1860
type: Stoichiometry
physical entity: Complex (Cytokine receptor/JAK/ JAK/STAT/ INFgamma)
stoichiometric coefficient: 1.0

Integrin beta-1
type: ProteinReference
xref: PTHR10082:SF28
xref: uniprot P53712 656
organism: Bos taurus

IkappaB s108 sa50 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.25
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

GPRK
type: ProteinReference
xref: P00840
standard name: G-protein receptor kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.GPRK
comment: ENTITY_REFERENCE_NOTES=Long Name: G-protein receptor kinase Synonym: Synonym not specified Accession: P00840
member entity reference: G protein-coupled receptor kinase
member entity reference: G protein-coupled receptor kinase 6
member entity reference: G protein-coupled receptor kinase 2
member entity reference: Beta-adrenergic receptor kinase 1

C-X-C chemokine receptor type 2 (Fragment)
type: ProteinReference
xref: uniprot Q28807 761
xref: PTHR10489:SF689
organism: Pan troglodytes

uniprot Q6DBV8 1178
type: UnificationXref
id: Q6DBV8
db: uniprot

uniprot B2GV73 1558
type: UnificationXref
id: B2GV73
db: uniprot

uniprot F7GQC5 94
type: UnificationXref
id: F7GQC5
db: uniprot

IkappaB
type: Protein
entity reference: IkappaB
feature: IkappaB s86 a132 rs2
feature: IkappaB s86 a132 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: PTHR12644:SF2
xref: uniprot H2QXW1 1582
organism: Pan troglodytes

PTHR10489:SF664
type: RelationshipXref
id: PTHR10489:SF664
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF117
type: RelationshipXref
id: PTHR24353:SF117
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF116
type: RelationshipXref
id: PTHR24353:SF116
db: PANTHER Family
relationship type: By Homology

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot A3KMS9 1142
organism: Danio rerio

uniprot H2QLB4 273
type: UnificationXref
id: H2QLB4
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F6QE96 57
organism: Macaca mulatta

TRANSCRIPTION
type: InteractionVocabulary

PARTICIPANT STOICHIOMETRY r26 1884
type: Stoichiometry
physical entity: CaMK
stoichiometric coefficient: 1.0

uniprot Q24210 574
type: UnificationXref
id: Q24210
db: uniprot

uniprot F7ERP8 332
type: UnificationXref
id: F7ERP8
db: uniprot

PARTICIPANT STOICHIOMETRY r26 1885
type: Stoichiometry
physical entity: CaMK
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
type: ProteinReference
xref: uniprot G5EBH0 1471
xref: PTHR10336:SF106
organism: Caenorhabditis elegans

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F1PRG4 55
organism: Canis lupus familiaris

uniprot D3ZD03 542
type: UnificationXref
id: D3ZD03
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: uniprot A0A1D5RHE7 464
xref: PTHR45627:SF6
organism: Macaca mulatta

uniprot P68032 1030
type: UnificationXref
id: P68032
db: uniprot

uniprot P91634 1388
type: UnificationXref
id: P91634
db: uniprot

PTHR12533:SF6
type: RelationshipXref
id: PTHR12533:SF6
db: PANTHER Family
relationship type: By Homology

PTHR12533:SF5
type: RelationshipXref
id: PTHR12533:SF5
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(K) subunit alpha
type: ProteinReference
xref: uniprot F6VL43 90
organism: Macaca mulatta

PTHR11801:SF2
type: RelationshipXref
id: PTHR11801:SF2
db: PANTHER Family
relationship type: By Homology

PTHR12533:SF4
type: RelationshipXref
id: PTHR12533:SF4
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 1823
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 1824
left: PKA
interaction type: STATE_TRANSITION
right: PKA

uniprot A0A2J8MSR9 381
type: UnificationXref
id: A0A2J8MSR9
db: uniprot

Leukotriene C4 synthase
type: ProteinReference
xref: uniprot Q60860 144
xref: PTHR10250:SF4
organism: Mus musculus

C-X-C chemokine receptor type 3
type: ProteinReference
xref: PTHR10489:SF671
xref: uniprot P49682 731
organism: Homo sapiens

Adenylate cyclase type 5
type: ProteinReference
xref: uniprot P84309 475
xref: PTHR45627:SF7
organism: Mus musculus

uniprot D4A280 387
type: UnificationXref
id: D4A280
db: uniprot

STATE_TRANSITION_LEFT__AP_1-RIGHT__AP_1-_r78
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 1805
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 1804
left: AP-1
interaction type: STATE_TRANSITION
right: AP-1

STATE_TRANSITION_LEFT__PDK1-RIGHT__PDK1-_r42
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 1825
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 1826
left: PDK1
interaction type: STATE_TRANSITION
right: PDK1

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF25
xref: uniprot Q6DF43 373
organism: Xenopus tropicalis

PTHR24169:SF18
type: RelationshipXref
id: PTHR24169:SF18
db: PANTHER Family
relationship type: By Homology

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot E2RJA0 394
organism: Canis lupus familiaris

ACTA1 isoform 1
type: ProteinReference
xref: uniprot H2Q1A9 981
xref: PTHR11937:SF193
organism: Pan troglodytes

uniprot A0A3Q1LM77 1534
type: UnificationXref
id: A0A3Q1LM77
db: uniprot

C-C chemokine receptor type 9
type: ProteinReference
xref: uniprot Q9WUT7 781
xref: PTHR10489:SF664
organism: Mus musculus

PTHR13715:SF52
type: RelationshipXref
id: PTHR13715:SF52
db: PANTHER Family
relationship type: By Homology

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot E2RB82 153
organism: Canis lupus familiaris

C-C motif chemokine 3
type: ProteinReference
xref: uniprot H9H490 821
organism: Macaca mulatta

PTHR13715:SF51
type: RelationshipXref
id: PTHR13715:SF51
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase spk1
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot P27638 281
organism: Schizosaccharomyces pombe

PTHR13715:SF53
type: RelationshipXref
id: PTHR13715:SF53
db: PANTHER Family
relationship type: By Homology

uniprot Q9VX82 1641
type: UnificationXref
id: Q9VX82
db: uniprot

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: uniprot P53731 1603
organism: Saccharomyces cerevisiae

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P10398 524
organism: Homo sapiens

STATE_TRANSITION_LEFT__Arachidonic_acid-RIGHT__Prostaglandin-_r79
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 1803
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 1802
left: Arachidonic acid
interaction type: STATE_TRANSITION
right: Prostaglandin

STAT
type: Protein
entity reference: STAT
feature: COMPLEX PARTICIPANT BINDING FEATURE s78 sa29 1699
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Myosin light chain kinase
type: ProteinReference
xref: uniprot A0A2I3TJW3 1645
xref: PTHR47633:SF1
organism: Pan troglodytes

PTHR10489:SF689
type: RelationshipXref
id: PTHR10489:SF689
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IKK-RIGHT__IKK-_r45
controller: AKT

Nuclear factor of activated T-cells 5
type: ProteinReference
xref: uniprot O94916 620
organism: Homo sapiens

Chemokine (C-X-C motif) receptor 4a
type: ProteinReference
xref: uniprot F1QCB2 672
xref: PTHR10489:SF594
organism: Danio rerio

uniprot F0ZK40 952
type: UnificationXref
id: F0ZK40
db: uniprot

PTHR24169:SF21
type: RelationshipXref
id: PTHR24169:SF21
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CIV4 973
xref: PTHR11937:SF150
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RJB3 315
xref: PTHR13809:SF11
organism: Canis lupus familiaris

Nuclear factor of activated T-cells, cytoplasmic 4
type: ProteinReference
xref: PTHR12533:SF11
xref: uniprot Q14934 625
organism: Homo sapiens

uniprot E2RL20 514
type: UnificationXref
id: E2RL20
db: uniprot

uniprot Q9Y623 1353
type: UnificationXref
id: Q9Y623
db: uniprot

Integrin alpha-M
type: ProteinReference
xref: uniprot P05555 647
xref: PTHR23220:SF130
organism: Mus musculus

uniprot P14056 528
type: UnificationXref
id: P14056
db: uniprot

Integrin beta-1
type: ProteinReference
xref: uniprot P05556 648
xref: PTHR10082:SF28
organism: Homo sapiens

uniprot Q63844 296
type: UnificationXref
id: Q63844
db: uniprot

PARTICIPANT STOICHIOMETRY r28 1874
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r28 1875
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

uniprot F6XUU0 969
type: UnificationXref
id: F6XUU0
db: uniprot

Myosin IIIA
type: ProteinReference
xref: PTHR46256:SF4
xref: uniprot D3ZZK7 1269
organism: Rattus norvegicus

uniprot A0A0G2K344 1354
type: UnificationXref
id: A0A0G2K344
db: uniprot

uniprot F6UA63 967
type: UnificationXref
id: F6UA63
db: uniprot

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot Q6DV79 163
organism: Gallus gallus

Phospholipase A2
type: ProteinReference
xref: uniprot F6QDY0 787
xref: PTHR10728:SF13
organism: Ornithorhynchus anatinus

uniprot A0A0G2K3R1 1226
type: UnificationXref
id: A0A0G2K3R1
db: uniprot

Transcription factor jun-B
type: ProteinReference
xref: uniprot F6U5C5 434
xref: PTHR11462:SF37
organism: Macaca mulatta

Myosin Light Chain Kinase related
type: ProteinReference
xref: uniprot Q23260 1653
organism: Caenorhabditis elegans

Actin 5
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9TZ58 917
organism: Physcomitrella patens

Uncharacterized protein
type: ProteinReference
xref: uniprot E9GNI4 1145
xref: PTHR24353:SF117
organism: Daphnia pulex

uniprot H2R3S4 688
type: UnificationXref
id: H2R3S4
db: uniprot

STAT s104 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

uniprot F6ZCW7 491
type: UnificationXref
id: F6ZCW7
db: uniprot

uniprot P05625 522
type: UnificationXref
id: P05625
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot Q7ZUQ0 1627
organism: Danio rerio

Actin-related protein 2/3 complex subunit 1A
type: ProteinReference
xref: uniprot Q92747 1630
xref: PTHR10709:SF11
organism: Homo sapiens

uniprot P50392 796
type: UnificationXref
id: P50392
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF477
xref: uniprot F6QWB7 960
organism: Ornithorhynchus anatinus

uniprot F6PVY4 1567
type: UnificationXref
id: F6PVY4
db: uniprot

uniprot H2QC98 1307
type: UnificationXref
id: H2QC98
db: uniprot

uniprot A0A2I3T7A8 1356
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

uniprot C3ZIB9 189
type: UnificationXref
id: C3ZIB9
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63085 284
xref: PTHR24055:SF203
organism: Mus musculus

Cyclooxygenase
type: Protein
entity reference: Cyclooxygenase
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63086 285
xref: PTHR24055:SF203
organism: Rattus norvegicus

uniprot P59768 357
type: UnificationXref
id: P59768
db: uniprot

uniprot F6WHR2 678
type: UnificationXref
id: F6WHR2
db: uniprot

uniprot H2QP14 408
type: UnificationXref
id: H2QP14
db: uniprot

uniprot D3ZX41 665
type: UnificationXref
id: D3ZX41
db: uniprot

Transcription factor RelB
type: ProteinReference
xref: uniprot Q04863 1109
xref: PTHR24169:SF18
organism: Mus musculus

uniprot F7FDA0 1370
type: UnificationXref
id: F7FDA0
db: uniprot

Grb
type: Protein
entity reference: Grb
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q9Y258 880
type: UnificationXref
id: Q9Y258
db: uniprot

PTHR12015:SF161
type: RelationshipXref
id: PTHR12015:SF161
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UC75 676
xref: PTHR10489:SF671
organism: Macaca mulatta

Integrin beta
type: ProteinReference
xref: uniprot B2RYB8 637
xref: PTHR10082:SF15
organism: Rattus norvegicus

NFkappaB
type: Protein
entity reference: NFkappaB
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A6QLN6 1261
type: UnificationXref
id: A6QLN6
db: uniprot

uniprot F1R6C7 1286
type: UnificationXref
id: F1R6C7
db: uniprot

C-X-C chemokine receptor type 4
type: ProteinReference
xref: uniprot Q3LSL6 763
xref: PTHR10489:SF594
organism: Canis lupus familiaris

PTHR12015:SF168
type: RelationshipXref
id: PTHR12015:SF168
db: PANTHER Family
relationship type: By Homology

IDA
type: EvidenceCodeVocabulary

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot P63097 108
organism: Bos taurus

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot P63096 107
organism: Homo sapiens

uniprot D3ZZK7 1269
type: UnificationXref
id: D3ZZK7
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF401
xref: uniprot O23236 275
organism: Arabidopsis thaliana

Rac family small GTPase 1
type: ProteinReference
xref: uniprot Q6GL60 248
organism: Xenopus tropicalis

Protein kinase C
type: ProteinReference
xref: uniprot F6XMN6 121
xref: PTHR24356:SF170
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Arachidonic_acid-RIGHT__Leukotriene-_r82
controller: Lipoxygenase

Suppressor of cytokine signaling 4
type: ProteinReference
xref: PTHR10155:SF21
xref: uniprot Q0VC91 1685
organism: Bos taurus

Son of sevenless homolog 1
type: ProteinReference
xref: uniprot Q62245 602
xref: PTHR23113:SF168
organism: Mus musculus

PTHR12015:SF170
type: RelationshipXref
id: PTHR12015:SF170
db: PANTHER Family
relationship type: By Homology

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: PTHR10709:SF10
xref: uniprot Q9WV32 1642
organism: Mus musculus

uniprot D4A942 666
type: UnificationXref
id: D4A942
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot K7BA21 1481
xref: PTHR10336:SF12
organism: Pan troglodytes

uniprot P07828 991
type: UnificationXref
id: P07828
db: uniprot

GTP s17 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot B3S5E4 924
type: UnificationXref
id: B3S5E4
db: uniprot

uniprot P02564 1314
type: UnificationXref
id: P02564
db: uniprot

MLCK
type: Protein
entity reference: MLCK
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7G8G5 156
type: UnificationXref
id: F7G8G5
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot P63078 359
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot P63077 358
organism: Rattus norvegicus

Arp2/3 complex 34 kDa subunit
type: ProteinReference
xref: PTHR12058:SF0
xref: uniprot Q6GL82 1623
organism: Xenopus tropicalis

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot H2Q960 407
organism: Pan troglodytes

HETERODIMER_ASSOCIATION_LEFT__Sos-_Shc-_Grb-RIGHT__Complex__Shc_Sos__Grb_-_r69
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 1836
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 1838
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 1837
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 1839
left: Grb
left: Shc
left: Sos
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Shc/Sos/ Grb)

uniprot F7ECA6 19
type: UnificationXref
id: F7ECA6
db: uniprot

Serine/threonine-protein kinase akt-1
type: ProteinReference
xref: uniprot Q17941 70
xref: PTHR24356:SF333
organism: Caenorhabditis elegans

uniprot A0A2I3T4Q0 1414
type: UnificationXref
id: A0A2I3T4Q0
db: uniprot

Transcription factor jun-B
type: ProteinReference
xref: PTHR11462:SF37
xref: uniprot Q0VBZ5 448
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MSU2 612
xref: PTHR12533:SF6
organism: Bos taurus

uniprot P53474 1007
type: UnificationXref
id: P53474
db: uniprot

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot Q63746 884
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot H9FVW1 1478
xref: PTHR10336:SF106
organism: Macaca mulatta

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot F1PS03 1457
xref: PTHR10336:SF173
organism: Canis lupus familiaris

uniprot Q7PUB7 1624
type: UnificationXref
id: Q7PUB7
db: uniprot

PTHR11801:SF48
type: RelationshipXref
id: PTHR11801:SF48
db: PANTHER Family
relationship type: By Homology

uniprot P05627 439
type: UnificationXref
id: P05627
db: uniprot

uniprot A0A2I3TQ88 152
type: UnificationXref
id: A0A2I3TQ88
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A567 204
xref: PTHR24072:SF136
organism: Monodelphis domestica

Galphaq s16 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Galphaq
stoichiometric coefficient: 1.0

Cdc42 homolog
type: ProteinReference
xref: uniprot Q17031 239
organism: Anopheles gambiae

uniprot F6W3Y0 399
type: UnificationXref
id: F6W3Y0
db: uniprot

uniprot F7FPY5 1577
type: UnificationXref
id: F7FPY5
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: uniprot F1MJV4 467
xref: PTHR45627:SF6
organism: Bos taurus

uniprot Q0UDS8 113
type: UnificationXref
id: Q0UDS8
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot A8KBH6 1128
organism: Xenopus tropicalis

Arachidonate 15-lipoxygenase
type: ProteinReference
xref: uniprot Q02759 142
xref: PTHR11771:SF33
organism: Rattus norvegicus

MYH14 isoform 6
type: ProteinReference
xref: uniprot A0A2I3RKA2 1252
xref: PTHR45615:SF31
organism: Pan troglodytes

uniprot Q1LYG2 530
type: UnificationXref
id: Q1LYG2
db: uniprot

uniprot Q5MD62 765
type: UnificationXref
id: Q5MD62
db: uniprot

PLA2
type: ProteinReference
xref: P00855
standard name: Phospholipase A2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Phospholipase A2 Synonym: Synonym not specified Accession: P00855
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.PLA2
member entity reference: Cytosolic phospholipase A2
member entity reference: Phospholipase A2

uniprot Q9QUI0 1127
type: UnificationXref
id: Q9QUI0
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r25
control type: ACTIVATION
controller: IP3R

uniprot Q99616 877
type: UnificationXref
id: Q99616
db: uniprot

uniprot A0A3Q1MS81 1258
type: UnificationXref
id: A0A3Q1MS81
db: uniprot

uniprot C3YP58 938
type: UnificationXref
id: C3YP58
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F1Q3M8 1363
xref: PTHR10048:SF107
organism: Canis lupus familiaris

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot Q9XWB7 1531
organism: Caenorhabditis elegans

uniprot Q04857 1217
type: UnificationXref
id: Q04857
db: uniprot

uniprot Q95KV0 1426
type: UnificationXref
id: Q95KV0
db: uniprot

uniprot H2Q960 407
type: UnificationXref
id: H2Q960
db: uniprot

uniprot P25025 713
type: UnificationXref
id: P25025
db: uniprot

uniprot Q7QEJ7 1389
type: UnificationXref
id: Q7QEJ7
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot H9FVU5 1376
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF35
xref: uniprot F6ZIC3 1296
organism: Macaca mulatta

uniprot K7E376 346
type: UnificationXref
id: K7E376
db: uniprot

RAS related 2
type: ProteinReference
xref: uniprot K7DK66 1402
organism: Pan troglodytes

uniprot Q9XTG7 79
type: UnificationXref
id: Q9XTG7
db: uniprot

Myosin heavy chain 13
type: ProteinReference
xref: uniprot F1MZX6 1275
organism: Bos taurus

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF2
xref: uniprot O97182 1599
organism: Drosophila melanogaster

uniprot F1MX38 154
type: UnificationXref
id: F1MX38
db: uniprot

uniprot F7FAW0 1299
type: UnificationXref
id: F7FAW0
db: uniprot

Myosin light chain kinase 2, skeletal/cardiac muscle
type: ProteinReference
xref: uniprot Q9H1R3 1657
xref: PTHR24347:SF373
organism: Homo sapiens

Calcium/calmodulin-dependent protein kinase type II delta 1 chain
type: ProteinReference
xref: PTHR24347:SF365
xref: uniprot Q6DEH3 579
organism: Danio rerio

uniprot P20701 651
type: UnificationXref
id: P20701
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7D2P3 561
xref: PTHR24347:SF365
organism: Monodelphis domestica

uniprot F6V461 321
type: UnificationXref
id: F6V461
db: uniprot

Collagen alpha-2(VI) chain
type: ProteinReference
xref: uniprot Q02788 1216
xref: PTHR24020:SF29
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: PTHR13809:SF25
xref: uniprot P59768 357
organism: Homo sapiens

uniprot E1B8P9 265
type: UnificationXref
id: E1B8P9
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot F6V461 321
organism: Ornithorhynchus anatinus

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F6Y841 1367
organism: Canis lupus familiaris

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 110

uniprot P32866 460
type: UnificationXref
id: P32866
db: uniprot

uniprot A8XSM9 1556
type: UnificationXref
id: A8XSM9
db: uniprot

uniprot P00517 1156
type: UnificationXref
id: P00517
db: uniprot

C-C motif chemokine receptor 4
type: ProteinReference
xref: PTHR10489:SF608
xref: uniprot G3V7C3 683
organism: Rattus norvegicus

uniprot Q62469 1220
type: UnificationXref
id: Q62469
db: uniprot

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF362
xref: uniprot Q7ZVI7 1076
organism: Danio rerio

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9TYG6 916
organism: Physcomitrella patens

Nuclear factor of activated T-cells, cytoplasmic 1
type: ProteinReference
xref: PTHR12533:SF5
xref: uniprot O95644 621
organism: Homo sapiens

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9TYG3 915
organism: Physcomitrella patens

uniprot Q8C6K9 1223
type: UnificationXref
id: Q8C6K9
db: uniprot

uniprot O88351 1424
type: UnificationXref
id: O88351
db: uniprot

uniprot E2RB82 153
type: UnificationXref
id: E2RB82
db: uniprot

uniprot F6XD59 1199
type: UnificationXref
id: F6XD59
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6SW23 1364
organism: Gallus gallus

uniprot F1P3X1 1278
type: UnificationXref
id: F1P3X1
db: uniprot

uniprot Q6TYS2 1069
type: UnificationXref
id: Q6TYS2
db: uniprot

MCG140437, isoform CRA_d
type: ProteinReference
xref: uniprot G3UW82 1304
xref: PTHR45615:SF39
organism: Mus musculus

Myosin heavy chain 14
type: ProteinReference
xref: uniprot F1LNF0 1271
xref: PTHR45615:SF31
organism: Rattus norvegicus

uniprot P30354 137
type: UnificationXref
id: P30354
db: uniprot

uniprot Q38E94 1047
type: UnificationXref
id: Q38E94
db: uniprot

uniprot O60674 547
type: UnificationXref
id: O60674
db: uniprot

uniprot F6XSJ9 201
type: UnificationXref
id: F6XSJ9
db: uniprot

uniprot P13533 1321
type: UnificationXref
id: P13533
db: uniprot

C-C motif chemokine receptor 7
type: ProteinReference
xref: PTHR10489:SF635
xref: uniprot J9P893 693
organism: Canis lupus familiaris

Integrin beta
type: ProteinReference
xref: uniprot K7E435 646
xref: PTHR10082:SF28
organism: Monodelphis domestica

uniprot A0A2I3S3U5 1254
type: UnificationXref
id: A0A2I3S3U5
db: uniprot

uniprot E2REI6 513
type: UnificationXref
id: E2REI6
db: uniprot

ACTC1 isoform 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot H2Q943 982
organism: Pan troglodytes

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q7ZVK8 300
xref: PTHR24055:SF393
organism: Danio rerio

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 215

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 76

uniprot Q6P378 1066
type: UnificationXref
id: Q6P378
db: uniprot

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF1
xref: uniprot F7H998 1578
organism: Macaca mulatta

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
type: ProteinReference
xref: uniprot Q22070 1504
organism: Caenorhabditis elegans

STAT s121 a176 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Secretion of New Cytokines and Chemokines
controller: pro-inflammatory anti-apoptotic genes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot D3ZQ51 386
organism: Rattus norvegicus

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q9UVF3 1086
organism: Yarrowia lipolytica

Collagen type VI alpha 2 chain
type: ProteinReference
xref: uniprot F1LNH3 1196
xref: PTHR24020:SF29
organism: Rattus norvegicus

uniprot Q90694 254
type: UnificationXref
id: Q90694
db: uniprot

uniprot P12109 1210
type: UnificationXref
id: P12109
db: uniprot

Mitogen-activated protein kinase KSS1
type: ProteinReference
xref: uniprot P14681 277
xref: PTHR24055:SF338
organism: Saccharomyces cerevisiae

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot F7EU36 976
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot Q0U5H3 238
organism: Phaeosphaeria nodorum

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PIP2-RIGHT__DAG-_IP3-_r22
controller: PLCbetagamma

uniprot E1BBJ7 450
type: UnificationXref
id: E1BBJ7
db: uniprot

Prostaglandin G/H synthase 1
type: ProteinReference
xref: uniprot P23219 535
organism: Homo sapiens

uniprot P27361 280
type: UnificationXref
id: P27361
db: uniprot

uniprot P49238 730
type: UnificationXref
id: P49238
db: uniprot

C-C motif chemokine 4-like
type: ProteinReference
xref: uniprot Q8NHW4 873
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot E2RQM0 1448
organism: Canis lupus familiaris

uniprot Q9FXT7 302
type: UnificationXref
id: Q9FXT7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot W4ZD41 1090
xref: PTHR11937:SF446
organism: Strongylocentrotus purpuratus

uniprot Q6P8G3 1068
type: UnificationXref
id: Q6P8G3
db: uniprot

Cytoplasmatic actin
type: ProteinReference
xref: PTHR11937:SF423
xref: uniprot E9HGF5 950
organism: Daphnia pulex

STATE_TRANSITION_LEFT__Myosin-RIGHT__Myosin-_r38
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 1835
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 1834
left: Myosin
interaction type: STATE_TRANSITION
right: Myosin

uniprot Q05144 237
type: UnificationXref
id: Q05144
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q6P023 297
xref: PTHR24055:SF203
organism: Danio rerio

IL2 s98 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IL2
stoichiometric coefficient: 1.0

uniprot A0A0R4IAV4 429
type: UnificationXref
id: A0A0R4IAV4
db: uniprot

uniprot P84309 475
type: UnificationXref
id: P84309
db: uniprot

uniprot Q4L0E8 176
type: UnificationXref
id: Q4L0E8
db: uniprot

Myosin light chain kinase 3
type: ProteinReference
xref: PTHR24347:SF394
xref: uniprot Q32MK0 1655
organism: Homo sapiens

uniprot P0C540 994
type: UnificationXref
id: P0C540
db: uniprot

CHKR s207 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHKR
stoichiometric coefficient: 1.0

uniprot O75914 409
type: UnificationXref
id: O75914
db: uniprot

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Complex__Cytokine_receptor_IL2_-_STAT-_JAK-RIGHT__Complex__Cytokine_receptor_IL2__STAT_JAK__JAK_-_r87
controller: JAK

uniprot Q6URW6 1340
type: UnificationXref
id: Q6URW6
db: uniprot

Adenylate cyclase type 6
type: ProteinReference
xref: uniprot O43306 471
xref: PTHR45627:SF11
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r74
controller: Complex (Shc/Sos/ Grb)

uniprot B1WBX9 1666
type: UnificationXref
id: B1WBX9
db: uniprot

ncbitaxon 7955 12
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot O15511 1590
type: UnificationXref
id: O15511
db: uniprot

uniprot O95622 472
type: UnificationXref
id: O95622
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 17

uniprot F7G7I9 335
type: UnificationXref
id: F7G7I9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UA54 966
xref: PTHR11937:SF445
organism: Macaca mulatta

Integrin alpha-L
type: ProteinReference
xref: uniprot P20701 651
xref: PTHR23220:SF84
organism: Homo sapiens

Raf-1
type: Protein
entity reference: Raf-1
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7G3M7 169
type: UnificationXref
id: F7G3M7
db: uniprot

uniprot F7ES59 1118
type: UnificationXref
id: F7ES59
db: uniprot

uniprot P70227 499
type: UnificationXref
id: P70227
db: uniprot

uniprot Q7ZSZ9 252
type: UnificationXref
id: Q7ZSZ9
db: uniprot

Cytokine receptor
type: Protein
entity reference: Cytokine receptor
feature: ACTIVE 46

TRIGGER
type: RelationshipTypeVocabulary

MYH3 protein
type: ProteinReference
xref: PTHR45615:SF6
xref: uniprot A6QPA6 1262
organism: Bos taurus

Myosin-4
type: ProteinReference
xref: uniprot Q5SX39 1335
xref: PTHR45615:SF2
organism: Mus musculus

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot Q62159 1125
organism: Mus musculus

MYH4 isoform 1
type: ProteinReference
xref: uniprot H2R9J3 1311
xref: PTHR45615:SF2
organism: Pan troglodytes

Suppressor of cytokine signaling 6
type: ProteinReference
xref: uniprot B2WUP2 1667
xref: PTHR10155:SF27
organism: Gallus gallus

Myosin-14
type: ProteinReference
xref: PTHR45615:SF31
xref: uniprot Q6URW6 1340
organism: Mus musculus

C-C motif chemokine 8
type: ProteinReference
xref: uniprot Q9Z121 882
organism: Mus musculus

uniprot Q13557 573
type: UnificationXref
id: Q13557
db: uniprot

Myosin-1
type: ProteinReference
xref: uniprot Q5SX40 1336
xref: PTHR45615:SF3
organism: Mus musculus

Platelet factor 4
type: ProteinReference
xref: uniprot Q9Z126 883
xref: PTHR10179:SF43
organism: Mus musculus

uniprot Q9CVB6 1633
type: UnificationXref
id: Q9CVB6
db: uniprot

uniprot F1N7C3 596
type: UnificationXref
id: F1N7C3
db: uniprot

uniprot P25089 714
type: UnificationXref
id: P25089
db: uniprot

uniprot A0A3Q2U980 1394
type: UnificationXref
id: A0A3Q2U980
db: uniprot

uniprot F1NM49 1277
type: UnificationXref
id: F1NM49
db: uniprot

uniprot Q924U0 772
type: UnificationXref
id: Q924U0
db: uniprot

uniprot P10587 1316
type: UnificationXref
id: P10587
db: uniprot

Myosin heavy chain 14
type: ProteinReference
xref: uniprot F1PYS6 1283
xref: PTHR45615:SF31
organism: Canis lupus familiaris

uniprot Q60680 1425
type: UnificationXref
id: Q60680
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VBA7 590
xref: PTHR12305:SF81
organism: Macaca mulatta

uniprot H9EQQ4 1155
type: UnificationXref
id: H9EQQ4
db: uniprot

uniprot P11799 1650
type: UnificationXref
id: P11799
db: uniprot

uniprot Q22070 1504
type: UnificationXref
id: Q22070
db: uniprot

uniprot F6SCP4 963
type: UnificationXref
id: F6SCP4
db: uniprot

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF362
xref: uniprot Q7ZVF9 1075
organism: Danio rerio

uniprot Q388U5 1173
type: UnificationXref
id: Q388U5
db: uniprot

uniprot D3ZS84 1668
type: UnificationXref
id: D3ZS84
db: uniprot

uniprot P08134 1121
type: UnificationXref
id: P08134
db: uniprot

uniprot F6VHF7 489
type: UnificationXref
id: F6VHF7
db: uniprot

uniprot B7PBG2 925
type: UnificationXref
id: B7PBG2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot F6UA63 967
organism: Macaca mulatta

uniprot Q9JHG7 1391
type: UnificationXref
id: Q9JHG7
db: uniprot

uniprot P60706 1014
type: UnificationXref
id: P60706
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_r31
controller: GEF

uniprot F7FD32 93
type: UnificationXref
id: F7FD32
db: uniprot

Actin, alpha 2, smooth muscle, aorta
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot F2Z4N0 957
organism: Canis lupus familiaris

uniprot H2R9L7 819
type: UnificationXref
id: H2R9L7
db: uniprot

uniprot P02778 829
type: UnificationXref
id: P02778
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F6SFG7 1398
organism: Macaca mulatta

uniprot Q7QK56 73
type: UnificationXref
id: Q7QK56
db: uniprot

uniprot F7AZP2 1674
type: UnificationXref
id: F7AZP2
db: uniprot

Actin, gamma 2, smooth muscle, enteric
type: ProteinReference
xref: uniprot F2Z4N8 959
xref: PTHR11937:SF445
organism: Canis lupus familiaris

Actin, alpha, cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot F2Z4N7 958
organism: Canis lupus familiaris

uniprot A0A2I3SQU2 1255
type: UnificationXref
id: A0A2I3SQU2
db: uniprot

Interferon gamma
type: ProteinReference
xref: PTHR11419:SF0
xref: uniprot P01579 1658
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UJE8 89
organism: Monodelphis domestica

HETERODIMER_ASSOCIATION_LEFT__Complex__Cytokine_receptor_INFgamma_-_JAK-RIGHT__Complex__Cytokine_receptor_JAK__JAK_INFgamma_-_r58
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1882
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1883
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1881
left: Complex (Cytokine receptor/INFgamma)
left: JAK
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Cytokine receptor/JAK/ JAK/INFgamma)

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q9WUA6 78
xref: PTHR24356:SF190
organism: Mus musculus

Actin alpha cardiac muscle 1b
type: ProteinReference
xref: PTHR11937:SF184
xref: uniprot Q9I8V1 1083
organism: Danio rerio

uniprot P10987 1000
type: UnificationXref
id: P10987
db: uniprot

uniprot H3FCG4 985
type: UnificationXref
id: H3FCG4
db: uniprot

Ras
type: ProteinReference
xref: P00869
standard name: Rat Sarcoma GTP-binding protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.Ras
comment: ENTITY_REFERENCE_NOTES=Long Name: Rat Sarcoma GTP-binding protein Synonym: Rat Sarcoma GTP-binding protein Accession: P00869
member entity reference: RAS related
member entity reference: GTPase KRas
member entity reference: Ras-like protein 2
member entity reference: Uncharacterized protein
member entity reference: KRAS isoform 4
member entity reference: Ras-related protein R-Ras
member entity reference: GTPase NRas
member entity reference: NRAS protein
member entity reference: Protein ras-1
member entity reference: RAS related 2
member entity reference: NRAS isoform 1

uniprot F7G4Q0 1148
type: UnificationXref
id: F7G4Q0
db: uniprot

Galphai/q
type: Protein
entity reference: Galphai/q
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa16 1749
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot E2RKR0 1416
type: UnificationXref
id: E2RKR0
db: uniprot

uniprot A8XS95 909
type: UnificationXref
id: A8XS95
db: uniprot

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa8 1729
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa13 1755
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Integrin beta
type: ProteinReference
xref: uniprot G3V7M2 644
xref: PTHR10082:SF36
organism: Rattus norvegicus

Regulator of G-protein signaling 1
type: ProteinReference
xref: uniprot Q9JL25 178
xref: PTHR10845:SF34
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot F7BVQ1 1467
organism: Monodelphis domestica

C-C motif chemokine 22
type: ProteinReference
xref: PTHR12015:SF102
xref: uniprot O00626 823
organism: Homo sapiens

uniprot A8XT67 1557
type: UnificationXref
id: A8XT67
db: uniprot

PARTICIPANT STOICHIOMETRY r33 1850
type: Stoichiometry
physical entity: Cdc42
stoichiometric coefficient: 1.0

Interferon gamma
type: ProteinReference
xref: PTHR11419:SF0
xref: uniprot P01580 1659
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r33 1851
type: Stoichiometry
physical entity: Cdc42
stoichiometric coefficient: 1.0

Interferon gamma
type: ProteinReference
xref: PTHR11419:SF0
xref: uniprot P01581 1660
organism: Rattus norvegicus

uniprot Q39032 1505
type: UnificationXref
id: Q39032
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 186

uniprot B8A561 1266
type: UnificationXref
id: B8A561
db: uniprot

uniprot P20292 135
type: UnificationXref
id: P20292
db: uniprot

uniprot P05132 1158
type: UnificationXref
id: P05132
db: uniprot

uniprot O35904 1378
type: UnificationXref
id: O35904
db: uniprot

AGAP008039-PA (Fragment)
type: ProteinReference
xref: uniprot Q7Q3T7 1183
xref: PTHR24353:SF117
organism: Anopheles gambiae

AGAP001573-PA
type: ProteinReference
xref: uniprot Q380U3 244
organism: Anopheles gambiae

uniprot P62736 1019
type: UnificationXref
id: P62736
db: uniprot

uniprot O15530 148
type: UnificationXref
id: O15530
db: uniprot

uniprot Q553U6 1051
type: UnificationXref
id: Q553U6
db: uniprot

Nuclear factor of activated T-cells, cytoplasmic 4
type: ProteinReference
xref: PTHR12533:SF11
xref: uniprot Q8K120 626
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit 1
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot P12370 1162
organism: Drosophila melanogaster

uniprot G3V7C3 683
type: UnificationXref
id: G3V7C3
db: uniprot

Putative actin-22
type: ProteinReference
xref: uniprot Q553U6 1051
xref: PTHR11937:SF421
organism: Dictyostelium discoideum

uniprot Q7K6A0 1180
type: UnificationXref
id: Q7K6A0
db: uniprot

uniprot Q7ZWH4 1628
type: UnificationXref
id: Q7ZWH4
db: uniprot

C-C motif chemokine
type: ProteinReference
xref: uniprot H2R9L7 819
organism: Pan troglodytes

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot Q08E52 413
organism: Bos taurus

uniprot P22437 534
type: UnificationXref
id: P22437
db: uniprot

PTHR10489:SF627
type: RelationshipXref
id: PTHR10489:SF627
db: PANTHER Family
relationship type: By Homology

uniprot E1BIS1 1670
type: UnificationXref
id: E1BIS1
db: uniprot

Collagen alpha-1(XIV) chain
type: ProteinReference
xref: PTHR24020:SF15
xref: uniprot Q80X19 1222
organism: Mus musculus

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E1BCP6 543
xref: PTHR45807:SF1
organism: Bos taurus

Rac family small GTPase 1a
type: ProteinReference
xref: uniprot Q7ZSZ9 252
organism: Danio rerio

MYH9 isoform 1
type: ProteinReference
xref: uniprot A0A2I3SQU2 1255
xref: PTHR45615:SF16
organism: Pan troglodytes

IL2 s100 sa45 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IL2
stoichiometric coefficient: 1.0

Grb s29 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb
stoichiometric coefficient: 1.0

uniprot Q6XNL8 1070
type: UnificationXref
id: Q6XNL8
db: uniprot

uniprot H2R9P0 690
type: UnificationXref
id: H2R9P0
db: uniprot

Myosin s71 a109 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Interferon gamma receptor 1
type: ProteinReference
xref: PTHR20859:SF5
xref: uniprot P15261 1240
organism: Mus musculus

STATE_TRANSITION_LEFT__IKK-RIGHT__IKK-_r45
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 1814
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 1813
left: IKK
interaction type: STATE_TRANSITION
right: IKK

uniprot P63267 1026
type: UnificationXref
id: P63267
db: uniprot

PTHR10489:SF637
type: RelationshipXref
id: PTHR10489:SF637
db: PANTHER Family
relationship type: By Homology

PTHR10489:SF635
type: RelationshipXref
id: PTHR10489:SF635
db: PANTHER Family
relationship type: By Homology

PAK
type: Protein
entity reference: PAK
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P63219 367
type: UnificationXref
id: P63219
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
type: ProteinReference
xref: uniprot E2RCV1 1361
xref: PTHR10048:SF34
organism: Canis lupus familiaris

uniprot D3ZGB1 608
type: UnificationXref
id: D3ZGB1
db: uniprot

uniprot F6UGY3 559
type: UnificationXref
id: F6UGY3
db: uniprot

uniprot Q9EQ16 773
type: UnificationXref
id: Q9EQ16
db: uniprot

uniprot Q09141 865
type: UnificationXref
id: Q09141
db: uniprot

uniprot F7H9Z6 809
type: UnificationXref
id: F7H9Z6
db: uniprot

Rho associated coiled-coil containing protein kinase 1
type: ProteinReference
xref: uniprot F7G2Y1 1690
xref: PTHR22988:SF33
organism: Monodelphis domestica

AGAP001676-PA
type: ProteinReference
xref: PTHR11937:SF397
xref: uniprot Q7PXZ8 1073
organism: Anopheles gambiae

uniprot P02572 989
type: UnificationXref
id: P02572
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot A0A2I3SYV7 541
xref: PTHR45807:SF1
organism: Pan troglodytes

GO GO:0005737 3
type: UnificationXref
id: GO:0005737
db: GO

uniprot H9FU32 517
type: UnificationXref
id: H9FU32
db: uniprot

INFgamma
type: Protein
entity reference: INFgamma
comment: SPECIES_TYPE=PROTEIN

uniprot F1Q376 1458
type: UnificationXref
id: F1Q376
db: uniprot

PTHR10489:SF608
type: RelationshipXref
id: PTHR10489:SF608
db: PANTHER Family
relationship type: By Homology

Putative actin-23
type: ProteinReference
xref: uniprot Q55EU6 1052
xref: PTHR11937:SF154
organism: Dictyostelium discoideum

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot H2QP14 408
organism: Pan troglodytes

C-C chemokine receptor type 7
type: ProteinReference
xref: PTHR10489:SF635
xref: uniprot Q5MD62 765
organism: Bos taurus

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: uniprot F7AQR3 18
organism: Macaca mulatta

PTHR10845:SF34
type: RelationshipXref
id: PTHR10845:SF34
db: PANTHER Family
relationship type: By Homology

Adenylate cyclase type 5
type: ProteinReference
xref: PTHR45627:SF7
xref: uniprot O95622 472
organism: Homo sapiens

uniprot Q3T035 1618
type: UnificationXref
id: Q3T035
db: uniprot

PTHR10845:SF32
type: RelationshipXref
id: PTHR10845:SF32
db: PANTHER Family
relationship type: By Homology

C-X-C chemokine receptor type 5
type: ProteinReference
xref: uniprot P32302 719
xref: PTHR10489:SF618
organism: Homo sapiens

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6R8N3 59
xref: PTHR24356:SF190
organism: Macaca mulatta

F-actin
type: Protein
entity reference: F-actin
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Actin-like protein 53D
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P45891 1006
organism: Drosophila melanogaster

C-C motif chemokine receptor 7
type: ProteinReference
xref: PTHR10489:SF635
xref: uniprot H2R9P0 690
organism: Pan troglodytes

Myosin-2
type: ProteinReference
xref: uniprot F1MRC2 1274
xref: PTHR34491:SF33
organism: Bos taurus

PTHR10489:SF618
type: RelationshipXref
id: PTHR10489:SF618
db: PANTHER Family
relationship type: By Homology

NFAT
type: Protein
entity reference: NFAT
feature: ACTIVE 46
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q13469 624
type: UnificationXref
id: Q13469
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot P40518 1602
organism: Saccharomyces cerevisiae

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2UD13 483
xref: PTHR13715:SF52
organism: Gallus gallus

PTHR10489:SF611
type: RelationshipXref
id: PTHR10489:SF611
db: PANTHER Family
relationship type: By Homology

uniprot P28291 843
type: UnificationXref
id: P28291
db: uniprot

Gbetagamma s5 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbetagamma
stoichiometric coefficient: 1.0

uniprot P25024 712
type: UnificationXref
id: P25024
db: uniprot

uniprot P61275 853
type: UnificationXref
id: P61275
db: uniprot

Protein kinase A catalytic subunit
type: ProteinReference
xref: uniprot Q388U5 1173
xref: PTHR24353:SF37
organism: Trypanosoma brucei

Rho-associated protein kinase 1
type: ProteinReference
xref: uniprot Q63644 1693
xref: PTHR22988:SF33
organism: Rattus norvegicus

PTHR24353:SF73
type: RelationshipXref
id: PTHR24353:SF73
db: PANTHER Family
relationship type: By Homology

uniprot E9PWQ3 1195
type: UnificationXref
id: E9PWQ3
db: uniprot

uniprot K7CDC2 64
type: UnificationXref
id: K7CDC2
db: uniprot

CHKR s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHKR
stoichiometric coefficient: 1.0

uniprot P42336 1381
type: UnificationXref
id: P42336
db: uniprot

Collagen alpha-1(XII) chain
type: ProteinReference
xref: PTHR24020:SF17
xref: uniprot P13944 1213
organism: Gallus gallus

GTP s22 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot P63261 1025
type: UnificationXref
id: P63261
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5F3B5 41
organism: Gallus gallus

uniprot H2RCA7 691
type: UnificationXref
id: H2RCA7
db: uniprot

uniprot F6R9F4 961
type: UnificationXref
id: F6R9F4
db: uniprot

PTHR24070:SF388
type: RelationshipXref
id: PTHR24070:SF388
db: PANTHER Family
relationship type: By Homology

uniprot Q9NPC1 777
type: UnificationXref
id: Q9NPC1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LVP1 628
xref: PTHR24418:SF94
organism: Bos taurus

INFgamma
type: Protein
entity reference: INFgamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa21 1759
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q8K3R3 1518
type: UnificationXref
id: Q8K3R3
db: uniprot

Adenylate cyclase type 6
type: ProteinReference
xref: PTHR45627:SF11
xref: uniprot Q01341 476
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: uniprot F7A632 1130
xref: PTHR24356:SF158
organism: Monodelphis domestica

uniprot E2RCV1 1361
type: UnificationXref
id: E2RCV1
db: uniprot

uniprot Q9VXE5 428
type: UnificationXref
id: Q9VXE5
db: uniprot

uniprot Q9TU25 258
type: UnificationXref
id: Q9TU25
db: uniprot

uniprot H2QD32 684
type: UnificationXref
id: H2QD32
db: uniprot

uniprot Q9LY51 1526
type: UnificationXref
id: Q9LY51
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot K7C8Z4 1482
organism: Pan troglodytes

uniprot H2R4R8 564
type: UnificationXref
id: H2R4R8
db: uniprot

CHK
type: Protein
entity reference: CHK
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5QXV8 1434
type: UnificationXref
id: A0A1D5QXV8
db: uniprot

uniprot P40792 222
type: UnificationXref
id: P40792
db: uniprot

C-C motif chemokine 5
type: ProteinReference
xref: PTHR12015:SF170
xref: uniprot O97919 827
organism: Bos taurus

uniprot F1PNY0 451
type: UnificationXref
id: F1PNY0
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot H2R8U9 600
organism: Pan troglodytes

uniprot Q9BE40 1349
type: UnificationXref
id: Q9BE40
db: uniprot

uniprot P05126 1135
type: UnificationXref
id: P05126
db: uniprot

uniprot O15144 1588
type: UnificationXref
id: O15144
db: uniprot

ACTIVE 46
type: EntityFeature
comment: Active state

F-actin
type: Protein
entity reference: F-actin
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7FKL1 404
type: UnificationXref
id: F7FKL1
db: uniprot

ncbitaxon 3702 276
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot Q03206 235
type: UnificationXref
id: Q03206
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3KRE3 369
xref: PTHR13809:SF6
organism: Rattus norvegicus

uniprot C3ZMR2 942
type: UnificationXref
id: C3ZMR2
db: uniprot

uniprot O15357 453
type: UnificationXref
id: O15357
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QVF5 1250
xref: PTHR45615:SF1
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QVF6 551
xref: PTHR23122:SF40
organism: Macaca mulatta

uniprot F6SCX2 1290
type: UnificationXref
id: F6SCX2
db: uniprot

uniprot F7AG99 1200
type: UnificationXref
id: F7AG99
db: uniprot

uniprot K7BMJ0 1680
type: UnificationXref
id: K7BMJ0
db: uniprot

PTHR24353:SF82
type: RelationshipXref
id: PTHR24353:SF82
db: PANTHER Family
relationship type: By Homology

uniprot Q7Z406 1341
type: UnificationXref
id: Q7Z406
db: uniprot

Rho family GTPase
type: ProteinReference
xref: uniprot C4M5Q7 190
organism: Entamoeba histolytica

PTHR12391:SF4
type: RelationshipXref
id: PTHR12391:SF4
db: PANTHER Family
relationship type: By Homology

uniprot O89100 583
type: UnificationXref
id: O89100
db: uniprot

SHC-transforming protein 1
type: ProteinReference
xref: uniprot Q0IIE2 1236
xref: PTHR10337:SF2
organism: Bos taurus

PTHR12391:SF1
type: RelationshipXref
id: PTHR12391:SF1
db: PANTHER Family
relationship type: By Homology

PTHR12391:SF0
type: RelationshipXref
id: PTHR12391:SF0
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF37
type: RelationshipXref
id: PTHR24353:SF37
db: PANTHER Family
relationship type: By Homology

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q75D00 1071
organism: Ashbya gossypii

uniprot F6ZIC3 1296
type: UnificationXref
id: F6ZIC3
db: uniprot

uniprot P50229 848
type: UnificationXref
id: P50229
db: uniprot

uniprot A0A2I3RVJ5 800
type: UnificationXref
id: A0A2I3RVJ5
db: uniprot

uniprot F7GE67 1302
type: UnificationXref
id: F7GE67
db: uniprot

uniprot E1BHU9 466
type: UnificationXref
id: E1BHU9
db: uniprot

IKK s85 a130 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZGX8 1399
xref: PTHR24070:SF245
organism: Macaca mulatta

uniprot P09217 122
type: UnificationXref
id: P09217
db: uniprot

uniprot P50230 849
type: UnificationXref
id: P50230
db: uniprot

PTHR10489:SF594
type: RelationshipXref
id: PTHR10489:SF594
db: PANTHER Family
relationship type: By Homology

uniprot O14936 566
type: UnificationXref
id: O14936
db: uniprot

Proto-oncogene c-Rel
type: ProteinReference
xref: uniprot P15307 1103
xref: PTHR24169:SF4
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF446
xref: uniprot F6R9F4 961
organism: Monodelphis domestica

C-C motif chemokine 21a
type: ProteinReference
xref: uniprot P84444 860
organism: Mus musculus

uniprot F1PYS6 1283
type: UnificationXref
id: F1PYS6
db: uniprot

Actin, indirect flight muscle
type: ProteinReference
xref: PTHR11937:SF397
xref: uniprot P83967 1040
organism: Drosophila melanogaster

uniprot Q86YW0 1515
type: UnificationXref
id: Q86YW0
db: uniprot

PTHR24020:SF18
type: RelationshipXref
id: PTHR24020:SF18
db: PANTHER Family
relationship type: By Homology

uniprot G1K2B9 1203
type: UnificationXref
id: G1K2B9
db: uniprot

ncbitaxon 6945 186
type: UnificationXref
id: 6945
db: ncbitaxon

PTHR24020:SF17
type: RelationshipXref
id: PTHR24020:SF17
db: PANTHER Family
relationship type: By Homology

PTHR24020:SF15
type: RelationshipXref
id: PTHR24020:SF15
db: PANTHER Family
relationship type: By Homology

ncbitaxon 214684 1056
type: UnificationXref
id: 214684
db: ncbitaxon

PTHR24020:SF13
type: RelationshipXref
id: PTHR24020:SF13
db: PANTHER Family
relationship type: By Homology

NFkappaB
type: Protein
entity reference: NFkappaB
feature: ACTIVE 46
feature: COMPLEX PARTICIPANT BINDING FEATURE s107 sa49 1761
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

AP-1
type: ProteinReference
xref: P00838
standard name: activator protein-1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.AP-1
comment: ENTITY_REFERENCE_NOTES=Long Name: Activator protein-1 Synonym: Synonym not specified Accession: P00838
member entity reference: Transcription factor jun-B
member entity reference: Transcription factor jun-D
member entity reference: Transcription factor AP-1
member entity reference: Jun proto-oncogene
member entity reference: JunB proto-oncogene, AP-1 transcription factor subunit
member entity reference: Uncharacterized protein
member entity reference: JunD proto-oncogene, AP-1 transcription factor subunit
member entity reference: Jun proto-oncogene, AP-1 transcription factor subunit
member entity reference: JUNB isoform 1
member entity reference: JunB proto-oncogene, AP-1 transcription factor subunit b

uniprot Q8MJW8 771
type: UnificationXref
id: Q8MJW8
db: uniprot

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P0CY33 211
organism: Candida albicans

Serine/threonine-protein kinase PAK 5
type: ProteinReference
xref: uniprot D4A280 387
organism: Rattus norvegicus

ncbitaxon 9598 10
type: UnificationXref
id: 9598
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR12533:SF5
xref: uniprot F6Z7T2 615
organism: Macaca mulatta

uniprot F6QE96 57
type: UnificationXref
id: F6QE96
db: uniprot

C-C motif chemokine receptor 3
type: ProteinReference
xref: uniprot H2R0Z4 687
xref: PTHR10489:SF649
organism: Pan troglodytes

uniprot P60711 1017
type: UnificationXref
id: P60711
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Arp2_3-RIGHT__Arp2_3-_r37
controller: Cdc42

PTHR24020:SF29
type: RelationshipXref
id: PTHR24020:SF29
db: PANTHER Family
relationship type: By Homology

PTHR34491:SF33
type: RelationshipXref
id: PTHR34491:SF33
db: PANTHER Family
relationship type: By Homology

uniprot F5HEA9 268
type: UnificationXref
id: F5HEA9
db: uniprot

uniprot F6T4B4 643
type: UnificationXref
id: F6T4B4
db: uniprot

ncbitaxon 665079 84
type: UnificationXref
id: 665079
db: ncbitaxon

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
type: ProteinReference
xref: uniprot Q7ZW82 117
organism: Danio rerio

uniprot Q9P212 1528
type: UnificationXref
id: Q9P212
db: uniprot

uniprot Q8NHW4 873
type: UnificationXref
id: Q8NHW4
db: uniprot

Arp2/3 complex 34 kDa subunit
type: ProteinReference
xref: PTHR12058:SF0
xref: uniprot A0A2I3TL93 1550
organism: Pan troglodytes

Leukotriene C4 synthase
type: ProteinReference
xref: uniprot Q925U2 145
xref: PTHR10250:SF4
organism: Rattus norvegicus

C-C motif chemokine ligand 21
type: ProteinReference
xref: PTHR12015:SF72
xref: uniprot H2QX72 817
organism: Pan troglodytes

INHIBITION
type: Control
xref: INHIBITION
controlled: UNKNOWN_TRANSITION_LEFT__Complex__Galphai_q__GTP_-RIGHT__Complex__Galphai_GTP_-_r6
control type: INHIBITION
controller: RGS

C-C motif chemokine ligand 27
type: ProteinReference
xref: PTHR17502:SF4
xref: uniprot H2QX70 816
organism: Pan troglodytes

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot Q84UI5 301
xref: PTHR24055:SF466
organism: Oryza sativa

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E1C795 311
xref: PTHR13809:SF6
organism: Gallus gallus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
type: ProteinReference
xref: uniprot P32383 1494
organism: Saccharomyces cerevisiae

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot A8XMP5 1555
xref: PTHR12391:SF0
organism: Caenorhabditis briggsae

PTHR10336:SF173
type: RelationshipXref
id: PTHR10336:SF173
db: PANTHER Family
relationship type: By Homology

actin, muscle-like
type: ProteinReference
xref: uniprot A0A1W2WEN5 888
organism: Ciona intestinalis

Actin, alpha, cardiac muscle 1a
type: ProteinReference
xref: PTHR11937:SF150
xref: uniprot F1RCB6 956
organism: Danio rerio

uniprot F6RBZ7 199
type: UnificationXref
id: F6RBZ7
db: uniprot

PTHR24020:SF39
type: RelationshipXref
id: PTHR24020:SF39
db: PANTHER Family
relationship type: By Homology

PTHR24233:SF6
type: RelationshipXref
id: PTHR24233:SF6
db: PANTHER Family
relationship type: By Homology

PTHR24020:SF37
type: RelationshipXref
id: PTHR24020:SF37
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot G3V8K2 338
organism: Rattus norvegicus

TRANSPORT_LEFT__STAT-RIGHT__STAT-_r63
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 1854
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 1855
left: STAT
interaction type: TRANSPORT
right: STAT

AGAP001384-PA
type: ProteinReference
xref: uniprot Q7PXF7 1181
xref: PTHR24353:SF117
organism: Anopheles gambiae

Platelet factor 4
type: ProteinReference
xref: uniprot P06765 830
xref: PTHR10179:SF43
organism: Rattus norvegicus

Rho family GTPase
type: ProteinReference
xref: uniprot C4M5Z7 192
organism: Entamoeba histolytica

Tyrosine-protein kinase JAK2
type: ProteinReference
xref: uniprot Q62120 548
xref: PTHR45807:SF1
organism: Mus musculus

uniprot Q9UKX3 1352
type: UnificationXref
id: Q9UKX3
db: uniprot

uniprot Q562R1 1053
type: UnificationXref
id: Q562R1
db: uniprot

uniprot Q6PHZ2 580
type: UnificationXref
id: Q6PHZ2
db: uniprot

CX3C chemokine receptor 1
type: ProteinReference
xref: uniprot Q9Z0D9 784
xref: PTHR10489:SF637
organism: Mus musculus

uniprot Q13153 414
type: UnificationXref
id: Q13153
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5QUZ8 262
xref: PTHR24055:SF203
organism: Macaca mulatta

uniprot P05771 1136
type: UnificationXref
id: P05771
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MRY8 671
xref: PTHR24230:SF8
organism: Bos taurus

C-X-C motif chemokine 10
type: ProteinReference
xref: uniprot Q2KIQ8 866
xref: PTHR10179:SF47
organism: Bos taurus

uniprot Q90826 876
type: UnificationXref
id: Q90826
db: uniprot

Integrin beta-7
type: ProteinReference
xref: PTHR10082:SF36
xref: uniprot P26010 653
organism: Homo sapiens

Integrin beta-7
type: ProteinReference
xref: PTHR10082:SF36
xref: uniprot P26011 654
organism: Mus musculus

Inactive phospholipase C-like protein 1
type: ProteinReference
xref: uniprot Q3USB7 1507
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot P16885 1491
organism: Homo sapiens

uniprot G5EFI8 1472
type: UnificationXref
id: G5EFI8
db: uniprot

IP3R
type: ProteinReference
xref: P00842
standard name: Inositol 1,4,5-triphosphate receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES=Long Name: Inositol 1,4,5-triphosphate receptor Synonym: IP3 receptor Accession: P00842
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.ION_CHANNEL.IP3R
member entity reference: Inositol 1,4,5-trisphosphate receptor type 3
member entity reference: Inositol 1,4,5-trisphosphate receptor type 2
member entity reference: Uncharacterized protein
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1 isoform 3

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 217

Interleukin-8
type: ProteinReference
xref: uniprot P10145 831
xref: PTHR10179:SF42
organism: Homo sapiens

C-C motif chemokine 2
type: ProteinReference
xref: uniprot P10148 833
organism: Mus musculus

C-C motif chemokine 3
type: ProteinReference
xref: uniprot P10147 832
organism: Homo sapiens

STATE_TRANSITION_LEFT__MLCK-RIGHT__MLCK-_r34
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1847
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1846
left: MLCK
interaction type: STATE_TRANSITION
right: MLCK

uniprot Q6P023 297
type: UnificationXref
id: Q6P023
db: uniprot

uniprot P51683 740
type: UnificationXref
id: P51683
db: uniprot

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 1048

uniprot P63214 362
type: UnificationXref
id: P63214
db: uniprot

G-alpha subunit
type: ProteinReference
xref: uniprot Q0UDS8 113
organism: Phaeosphaeria nodorum

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot K7E376 346
organism: Monodelphis domestica

uniprot F1MGR9 611
type: UnificationXref
id: F1MGR9
db: uniprot

Actin, alpha sarcomeric/skeletal
type: ProteinReference
xref: uniprot Q6P8G3 1068
xref: PTHR11937:SF240
organism: Xenopus tropicalis

Nuclear factor of activated T-cells, cytoplasmic 4
type: ProteinReference
xref: PTHR12533:SF11
xref: uniprot D3Z9H7 607
organism: Rattus norvegicus

Transcription factor jun-B
type: ProteinReference
xref: PTHR11462:SF37
xref: uniprot P17275 442
organism: Homo sapiens

uniprot A0A2I3S4R3 81
type: UnificationXref
id: A0A2I3S4R3
db: uniprot

uniprot H2QPN2 812
type: UnificationXref
id: H2QPN2
db: uniprot

uniprot F7A818 492
type: UnificationXref
id: F7A818
db: uniprot

PDK1
type: ProteinReference
xref: P00831
standard name: 3-phosphoinositide-dependent protein kinase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.PDK1
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphoinositide-dependent protein kinases Synonym: PDPK1 Accession: P00831
member entity reference: 3-phosphoinositide-dependent protein kinase 1
member entity reference: 3-phosphoinositide dependent protein kinase 1
member entity reference: Uncharacterized protein

uniprot Q6Z437 298
type: UnificationXref
id: Q6Z437
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot A0A1D5QLW6 1433
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot A0A1D5QLW3 604
organism: Macaca mulatta

uniprot Q3MHR7 1616
type: UnificationXref
id: Q3MHR7
db: uniprot

uniprot P38408 36
type: UnificationXref
id: P38408
db: uniprot

uniprot F7B7V9 679
type: UnificationXref
id: F7B7V9
db: uniprot

uniprot A0A1D5Q4D0 1432
type: UnificationXref
id: A0A1D5Q4D0
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot Q05513 124
organism: Homo sapiens

uniprot P29353 1234
type: UnificationXref
id: P29353
db: uniprot

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: uniprot Q04982 529
organism: Gallus gallus

C5a anaphylatoxin chemotactic receptor 1
type: ProteinReference
xref: uniprot P30993 716
xref: PTHR24225:SF29
organism: Mus musculus

uniprot F7EI48 271
type: UnificationXref
id: F7EI48
db: uniprot

Calcium/calmodulin-dependent protein kinase type II subunit delta
type: ProteinReference
xref: uniprot Q6PHZ2 580
xref: PTHR24347:SF365
organism: Mus musculus

uniprot P79241 754
type: UnificationXref
id: P79241
db: uniprot

Galphaq
type: Protein
entity reference: Galphaq
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa12 1753
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot H3FCG4 985
organism: Pristionchus pacificus

uniprot P12110 1211
type: UnificationXref
id: P12110
db: uniprot

PLCbetagamma
type: ProteinReference
xref: P00874
standard name: Phospholipase C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.PLC_beta__gamma_
comment: ENTITY_REFERENCE_NOTES=Long Name: Phospholipase C Synonym: PLC Accession: P00874
member entity reference: Phosphoinositide phospholipase C 4
member entity reference: Inactive phospholipase C-like protein 1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
member entity reference: Phosphoinositide phospholipase C
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
member entity reference: Uncharacterized protein
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
member entity reference: Phosphoinositide phospholipase C 2
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
member entity reference: Phosphoinositide phospholipase C (Fragment)
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

uniprot F6QP11 58
type: UnificationXref
id: F6QP11
db: uniprot

uniprot Q9CXP8 376
type: UnificationXref
id: Q9CXP8
db: uniprot

PTHR10155:SF27
type: RelationshipXref
id: PTHR10155:SF27
db: PANTHER Family
relationship type: By Homology

uniprot H2R6C6 435
type: UnificationXref
id: H2R6C6
db: uniprot

PARTICIPANT STOICHIOMETRY r34 1846
type: Stoichiometry
physical entity: MLCK
stoichiometric coefficient: 1.0

CHK s7 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHK
stoichiometric coefficient: 1.0

uniprot A8WWE8 1554
type: UnificationXref
id: A8WWE8
db: uniprot

PARTICIPANT STOICHIOMETRY r34 1847
type: Stoichiometry
physical entity: MLCK
stoichiometric coefficient: 1.0

Complex (Shc/Sos/ Grb)
type: Complex
component stoichiometry: Sos s28 sa36 STOICHIOMETRY ID COMPLEX
component stoichiometry: Shc s27 sa35 STOICHIOMETRY ID COMPLEX
component stoichiometry: Grb s29 sa37 STOICHIOMETRY ID COMPLEX
component: Sos
component: Grb
component: Shc
feature: COMPLEX BINDING FEATURE s151 a221 1744
feature: COMPLEX BINDING FEATURE s151 a221 1746
feature: COMPLEX BINDING FEATURE s151 a221 1742
cellular location: cytoplasm

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DPD5 562
xref: PTHR23122:SF40
organism: Ornithorhynchus anatinus

Nuclear factor NF-kappa-B p100 subunit
type: ProteinReference
xref: PTHR24169:SF21
xref: uniprot Q9WTK5 1113
organism: Mus musculus

PTHR10155:SF21
type: RelationshipXref
id: PTHR10155:SF21
db: PANTHER Family
relationship type: By Homology

uniprot Q925U2 145
type: UnificationXref
id: Q925U2
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

uniprot A7RU31 897
type: UnificationXref
id: A7RU31
db: uniprot

TRANSPORT
type: InteractionVocabulary

uniprot Q14934 625
type: UnificationXref
id: Q14934
db: uniprot

NFAT
type: ProteinReference
xref: P00851
standard name: Nuclear factor of activated T cells
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Nuclear factor of activated T cells Synonym: NFAT Accession: P00851
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.NFAT
member entity reference: NFAT5 isoform 6
member entity reference: Nuclear factor of activated T cells 2
member entity reference: Nuclear factor of activated T-cells, cytoplasmic 1
member entity reference: Nuclear factor of activated T-cells, cytoplasmic 3
member entity reference: Uncharacterized protein
member entity reference: Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b
member entity reference: Nuclear factor of activated T-cells, cytoplasmic 4
member entity reference: Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b
member entity reference: Nuclear factor of activated T-cells, cytoplasmic 3 isoform 2
member entity reference: Nuclear factor of activated T-cells, cytoplasmic 2
member entity reference: NFATC3 isoform 2
member entity reference: Nuclear factor of activated T-cells 5
member entity reference: NFATC4 isoform 9
member entity reference: Nuclear factor of activated T cells 5

uniprot F6TWF0 398
type: UnificationXref
id: F6TWF0
db: uniprot

uniprot A8XMP5 1555
type: UnificationXref
id: A8XMP5
db: uniprot

PRKACG isoform 1
type: ProteinReference
xref: uniprot H2QXB9 1152
xref: PTHR24353:SF137
organism: Pan troglodytes

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A7ETS6 896
organism: Sclerotinia sclerotiorum

uniprot F7GL73 979
type: UnificationXref
id: F7GL73
db: uniprot

PTHR10155:SF17
type: RelationshipXref
id: PTHR10155:SF17
db: PANTHER Family
relationship type: By Homology

Rac1B, RHO family GTPase
type: ProteinReference
xref: uniprot F0ZQR3 196
organism: Dictyostelium purpureum

uniprot Q9XWB7 1531
type: UnificationXref
id: Q9XWB7
db: uniprot

Extracellular signal-regulated kinase 1
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot Q5A1D3 294
organism: Candida albicans

uniprot B1N2P0 920
type: UnificationXref
id: B1N2P0
db: uniprot

Phospholipase A2
type: ProteinReference
xref: PTHR10728:SF32
xref: uniprot F7HAF3 791
organism: Macaca mulatta

PTHR10155:SF15
type: RelationshipXref
id: PTHR10155:SF15
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR24020:SF17
xref: uniprot F7AGY1 1201
organism: Monodelphis domestica

C-C motif chemokine 2
type: ProteinReference
xref: uniprot P28291 843
organism: Bos taurus

uniprot F1PRG4 55
type: UnificationXref
id: F1PRG4
db: uniprot

Chemokine (C-C motif) receptor 10
type: ProteinReference
xref: uniprot D9ZDE4 668
xref: PTHR10489:SF773
organism: Bos taurus

uniprot F6UDX9 968
type: UnificationXref
id: F6UDX9
db: uniprot

uniprot H2PZQ7 1400
type: UnificationXref
id: H2PZQ7
db: uniprot

uniprot K9J7V0 565
type: UnificationXref
id: K9J7V0
db: uniprot

uniprot P63085 284
type: UnificationXref
id: P63085
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23122:SF40
xref: uniprot A0A3Q1LPV4 555
organism: Bos taurus

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 114

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E2RPW6 544
xref: PTHR45807:SF1
organism: Canis lupus familiaris

Myosin-8
type: ProteinReference
xref: uniprot Q076A4 1329
xref: PTHR45615:SF35
organism: Canis lupus familiaris

Myosin-4
type: ProteinReference
xref: PTHR45615:SF2
xref: uniprot Q076A5 1330
organism: Canis lupus familiaris

Myosin-1
type: ProteinReference
xref: PTHR45615:SF3
xref: uniprot Q076A6 1331
organism: Canis lupus familiaris

Developmental myosin heavy chain embryonic
type: ProteinReference
xref: PTHR45615:SF6
xref: uniprot Q076A8 1332
organism: Canis lupus familiaris

uniprot Q8ILW9 1080
type: UnificationXref
id: Q8ILW9
db: uniprot

uniprot O54857 592
type: UnificationXref
id: O54857
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot F6XUP1 400
organism: Macaca mulatta

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF477
xref: uniprot Q6NVA9 1065
organism: Xenopus tropicalis

uniprot G3V926 1420
type: UnificationXref
id: G3V926
db: uniprot

uniprot A0A1D5Q373 658
type: UnificationXref
id: A0A1D5Q373
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
type: ProteinReference
xref: uniprot P25455 1493
organism: Drosophila melanogaster

RGS
type: Protein
entity reference: RGS
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Interleukin-8
type: ProteinReference
xref: uniprot P41324 845
xref: PTHR10179:SF42
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r76
controller: Raf-1

Suppressor of cytokine signaling 7
type: ProteinReference
xref: uniprot Q8VHQ2 1686
xref: PTHR10155:SF5
organism: Mus musculus

Integrin alpha-9
type: ProteinReference
xref: uniprot B8JK39 638
xref: PTHR23220:SF69
organism: Mus musculus

uniprot Q6P640 1067
type: UnificationXref
id: Q6P640
db: uniprot

uniprot J9NRL7 1541
type: UnificationXref
id: J9NRL7
db: uniprot

Ras-related protein Rac2
type: ProteinReference
xref: uniprot P48554 224
organism: Drosophila melanogaster

uniprot F7G124 1301
type: UnificationXref
id: F7G124
db: uniprot

Monosiga brevicollis
type: BioSource
xref: ncbitaxon 81824 919

uniprot P43250 461
type: UnificationXref
id: P43250
db: uniprot

uniprot D4A5E7 1415
type: UnificationXref
id: D4A5E7
db: uniprot

uniprot D4A5Q1 1359
type: UnificationXref
id: D4A5Q1
db: uniprot

PTHR11937:SF411
type: RelationshipXref
id: PTHR11937:SF411
db: PANTHER Family
relationship type: By Homology

Actin, aortic smooth muscle
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot F1P476 954
organism: Gallus gallus

PTHR11937:SF414
type: RelationshipXref
id: PTHR11937:SF414
db: PANTHER Family
relationship type: By Homology

uniprot H2Q3W7 341
type: UnificationXref
id: H2Q3W7
db: uniprot

PTHR11937:SF410
type: RelationshipXref
id: PTHR11937:SF410
db: PANTHER Family
relationship type: By Homology

Suppressor of cytokine signaling 6
type: ProteinReference
xref: PTHR10155:SF17
xref: uniprot O14544 1682
organism: Homo sapiens

G protein subunit alpha i3
type: ProteinReference
xref: uniprot H2PZK9 95
organism: Pan troglodytes

AT17867p
type: ProteinReference
xref: uniprot Q7JWS8 251
organism: Drosophila melanogaster

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q17QZ0 417
organism: Bos taurus

CHK
type: ProteinReference
xref: P00856
standard name: Chemokine
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Chemokine Synonym: Synonym not specified Accession: P00856
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.CHK
member entity reference: C-C motif chemokine 20
member entity reference: Platelet factor 4
member entity reference: C-C motif chemokine
member entity reference: C-X3-C motif chemokine ligand 1
member entity reference: Multifunctional fusion protein
member entity reference: C-C motif chemokine 2
member entity reference: C-X-C motif chemokine 10
member entity reference: C-C motif chemokine 26
member entity reference: Small-inducible cytokine A27
member entity reference: C-C motif chemokine 5
member entity reference: C-C motif chemokine 8
member entity reference: C-C motif chemokine 3
member entity reference: C-C motif chemokine 27
member entity reference: Fractalkine
member entity reference: C-C motif chemokine 4 homolog
member entity reference: Platelet factor 4 variant
member entity reference: C-C motif chemokine ligand 2
member entity reference: C-C motif chemokine 4
member entity reference: C-C motif chemokine 12
member entity reference: C-X-C motif chemokine
member entity reference: C-C motif chemokine 21
member entity reference: C-C motif chemokine 22
member entity reference: Eotaxin
member entity reference: Interleukin-8
member entity reference: C-C motif chemokine 21b
member entity reference: C-C motif chemokine 7
member entity reference: C-C motif chemokine 3-like 1
member entity reference: C-C motif chemokine 13
member entity reference: Uncharacterized protein
member entity reference: C-C motif chemokine ligand 27
member entity reference: C-C motif chemokine 21a
member entity reference: C-C motif chemokine ligand 21
member entity reference: C-C motif chemokine 18

uniprot Q29RW1 1334
type: UnificationXref
id: Q29RW1
db: uniprot

C-C motif chemokine 22
type: ProteinReference
xref: PTHR12015:SF102
xref: uniprot O88430 825
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot E1BS97 389
organism: Gallus gallus

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 2

uniprot F6RNN7 614
type: UnificationXref
id: F6RNN7
db: uniprot

PTHR11937:SF408
type: RelationshipXref
id: PTHR11937:SF408
db: PANTHER Family
relationship type: By Homology

uniprot Q3MHJ9 576
type: UnificationXref
id: Q3MHJ9
db: uniprot

Transcription factor p65
type: ProteinReference
xref: uniprot Q04207 1108
organism: Mus musculus

uniprot K7CW85 1401
type: UnificationXref
id: K7CW85
db: uniprot

Transcription factor p65
type: ProteinReference
xref: uniprot Q04206 1107
organism: Homo sapiens

uniprot Q28807 761
type: UnificationXref
id: Q28807
db: uniprot

ncbitaxon 559292 215
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot P63270 1029
type: UnificationXref
id: P63270
db: uniprot

uniprot C3XYC3 927
type: UnificationXref
id: C3XYC3
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: PTHR13809:SF25
xref: uniprot P63212 360
organism: Bos taurus

uniprot O97182 1599
type: UnificationXref
id: O97182
db: uniprot

uniprot E1BKE7 484
type: UnificationXref
id: E1BKE7
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A8X1E0 1444
organism: Caenorhabditis briggsae

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P28482 282
xref: PTHR24055:SF203
organism: Homo sapiens

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot D3ZD03 542
xref: PTHR45807:SF6
organism: Rattus norvegicus

PTHR17502:SF4
type: RelationshipXref
id: PTHR17502:SF4
db: PANTHER Family
relationship type: By Homology

uniprot Q99P84 1524
type: UnificationXref
id: Q99P84
db: uniprot

uniprot P20359 1004
type: UnificationXref
id: P20359
db: uniprot

Shc
type: ProteinReference
xref: P00865
standard name: SH2 homology domain containing transforming protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: SH2 homology domain containing transforming protein Synonym: Synonym not specified Accession: P00865
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.Shc
member entity reference: SHC-transforming protein 1
member entity reference: SHC (Src homology 2 domain containing) transforming protein 1
member entity reference: Uncharacterized protein

uniprot P50151 354
type: UnificationXref
id: P50151
db: uniprot

uniprot P79188 750
type: UnificationXref
id: P79188
db: uniprot

Suppressor of cytokine signaling 4
type: ProteinReference
xref: PTHR10155:SF21
xref: uniprot E2RGD0 1671
organism: Canis lupus familiaris

uniprot F6UGQ3 558
type: UnificationXref
id: F6UGQ3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__F_actin-RIGHT__F_actin-_r39
controller: Arp2/3

C-X-C chemokine receptor type 3
type: ProteinReference
xref: PTHR10489:SF671
xref: uniprot O88410 705
organism: Mus musculus

DAG
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

C-C chemokine receptor type 3
type: ProteinReference
xref: uniprot O54814 702
organism: Rattus norvegicus

Arp2/3 complex 34 kDa subunit
type: ProteinReference
xref: PTHR12058:SF0
xref: uniprot A0A1D5RJ31 1548
organism: Macaca mulatta

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot Q6Z3Y9 1513
organism: Oryza sativa

uniprot Q8INB9 75
type: UnificationXref
id: Q8INB9
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P27361 280
xref: PTHR24055:SF393
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot Q01970 1499
xref: PTHR10336:SF11
organism: Homo sapiens

uniprot O96013 411
type: UnificationXref
id: O96013
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A7S0V7 899
organism: Nematostella vectensis

uniprot Q6DGB7 247
type: UnificationXref
id: Q6DGB7
db: uniprot

3-phosphoinositide dependent protein kinase 1
type: ProteinReference
xref: uniprot A0A2I3TN41 146
xref: PTHR24356:SF163
organism: Pan troglodytes

uniprot D3ZQ51 386
type: UnificationXref
id: D3ZQ51
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F6ZC55 1465
organism: Monodelphis domestica

Protein serine/threonine kinase, putative
type: ProteinReference
xref: uniprot Q5KP84 1177
xref: PTHR24353:SF117
organism: Cryptococcus neoformans

Uncharacterized protein
type: ProteinReference
xref: PTHR24020:SF13
xref: uniprot F7AG99 1200
organism: Macaca mulatta

uniprot P16885 1491
type: UnificationXref
id: P16885
db: uniprot

PTHR10845:SF155
type: RelationshipXref
id: PTHR10845:SF155
db: PANTHER Family
relationship type: By Homology

Integrin
type: Protein
entity reference: Integrin
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa18 1733
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r88 1892
type: Stoichiometry
physical entity: Complex (Cytokine receptor/JAK/ JAK/IL2)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r88 1893
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

PTHR10489:SF928
type: RelationshipXref
id: PTHR10489:SF928
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF453
type: RelationshipXref
id: PTHR11937:SF453
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r88 1891
type: Stoichiometry
physical entity: Complex (Cytokine receptor/IL2/ STAT/JAK/ JAK)
stoichiometric coefficient: 1.0

uniprot O08648 1230
type: UnificationXref
id: O08648
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0JP99 384
organism: Xenopus tropicalis

uniprot Q01201 1106
type: UnificationXref
id: Q01201
db: uniprot

Inhibitor of kappaB kinase epsilon (Predicted)
type: ProteinReference
xref: uniprot D4A5E7 1415
xref: PTHR22969:SF10
organism: Rattus norvegicus

uniprot P47197 69
type: UnificationXref
id: P47197
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IKK-RIGHT__IKK-_r45
controller: PKCzeta

uniprot Q05062 236
type: UnificationXref
id: Q05062
db: uniprot

PARTICIPANT STOICHIOMETRY r40 1831
type: Stoichiometry
physical entity: PKCzeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r40 1830
type: Stoichiometry
physical entity: PKCzeta
stoichiometric coefficient: 1.0

uniprot F7F210 977
type: UnificationXref
id: F7F210
db: uniprot

Suppressor of cytokine signaling 7
type: ProteinReference
xref: PTHR10155:SF5
xref: uniprot O14512 1681
organism: Homo sapiens

uniprot C3YPV2 1560
type: UnificationXref
id: C3YPV2
db: uniprot

JAK s90 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JAK
stoichiometric coefficient: 2.0

PTHR11937:SF446
type: RelationshipXref
id: PTHR11937:SF446
db: PANTHER Family
relationship type: By Homology

Galphai
type: Protein
entity reference: Galphai
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa14 1719
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR11937:SF445
type: RelationshipXref
id: PTHR11937:SF445
db: PANTHER Family
relationship type: By Homology

Evidence 526
type: Evidence
evidence code: RCA
comment: SPACC P11345

uniprot Q9H1R3 1657
type: UnificationXref
id: Q9H1R3
db: uniprot

uniprot P25455 1493
type: UnificationXref
id: P25455
db: uniprot

Evidence 520
type: Evidence
evidence code: RCA
comment: SPACC P04049

Rac family small GTPase 3a
type: ProteinReference
xref: uniprot Q6DGB7 247
organism: Danio rerio

uniprot Q9JII9 774
type: UnificationXref
id: Q9JII9
db: uniprot

uniprot P91167 1609
type: UnificationXref
id: P91167
db: uniprot

Evidence 523
type: Evidence
evidence code: RCA
comment: SPACC P05625

von Willebrand factor
type: ProteinReference
xref: uniprot P04275 1209
xref: PTHR11339:SF361
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PIP3-RIGHT__PIP2-_re73
controller: SHIP

uniprot F6SHC1 1418
type: UnificationXref
id: F6SHC1
db: uniprot

Arachidonate 12-lipoxygenase, epidermal-type
type: ProteinReference
xref: PTHR11771:SF34
xref: uniprot P55249 141
organism: Mus musculus

uniprot A9TVP1 914
type: UnificationXref
id: A9TVP1
db: uniprot

SOCS
type: ProteinReference
xref: P00879
standard name: Suppressor of cytokine siganling
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.SOCS
comment: ENTITY_REFERENCE_NOTES=Long Name: Suppressor of cytokine siganling Synonym: Synonym not specified Accession: P00879
member entity reference: Uncharacterized protein
member entity reference: SOCS5 isoform 1
member entity reference: Suppressor of cytokine-signaling 5
member entity reference: Suppressor of cytokine signaling 4
member entity reference: Suppressor of cytokine signaling 7
member entity reference: RCG61633, isoform CRA_a
member entity reference: Cish protein
member entity reference: Suppressor of cytokine signaling 5
member entity reference: SOCS6 isoform 1
member entity reference: Suppressor of cytokine-signaling 6
member entity reference: Suppressor of cytokine signaling 6
member entity reference: SOCS4 isoform 1
member entity reference: Suppressor of cytokine-signaling 7

Ras
type: Protein
entity reference: Ras
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR11937:SF438
type: RelationshipXref
id: PTHR11937:SF438
db: PANTHER Family
relationship type: By Homology

uniprot Q5U1Y2 246
type: UnificationXref
id: Q5U1Y2
db: uniprot

uniprot P21462 710
type: UnificationXref
id: P21462
db: uniprot

uniprot O15145 1589
type: UnificationXref
id: O15145
db: uniprot

Regulator of G-protein signaling 18
type: ProteinReference
xref: PTHR10845:SF155
xref: uniprot Q4L0E8 176
organism: Rattus norvegicus

RELA proto-oncogene, NF-kB subunit
type: ProteinReference
xref: uniprot F1PCU1 1098
organism: Canis lupus familiaris

uniprot A5D7R9 1395
type: UnificationXref
id: A5D7R9
db: uniprot

uniprot F7BB02 329
type: UnificationXref
id: F7BB02
db: uniprot

uniprot F6QUW1 598
type: UnificationXref
id: F6QUW1
db: uniprot

C-C chemokine receptor type 10
type: ProteinReference
xref: PTHR10489:SF773
xref: uniprot F7B7V9 679
organism: Macaca mulatta

uniprot Q9VMH2 1639
type: UnificationXref
id: Q9VMH2
db: uniprot

NFAT
type: Protein
entity reference: NFAT
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DZJ9 616
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F0ZK40 952
xref: PTHR11937:SF154
organism: Dictyostelium purpureum

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot F6QTB5 1568
xref: PTHR10709:SF11
organism: Ornithorhynchus anatinus

PTHR11937:SF430
type: RelationshipXref
id: PTHR11937:SF430
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F1P3X1 1278
xref: PTHR45615:SF2
organism: Gallus gallus

Myosin, heavy chain 10, non-muscle
type: ProteinReference
xref: PTHR45615:SF24
xref: uniprot F1R3G4 1285
organism: Danio rerio

Evidence 532
type: Evidence
evidence code: RCA
comment: SPACC Q99N57

Mitogen-activated protein kinase 4
type: ProteinReference
xref: PTHR24055:SF196
xref: uniprot Q5Z859 295
organism: Oryza sativa

C-C chemokine receptor type 2
type: ProteinReference
xref: uniprot P41597 725
organism: Homo sapiens

PTHR11937:SF434
type: RelationshipXref
id: PTHR11937:SF434
db: PANTHER Family
relationship type: By Homology

NFkappaB s107 sa49 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NFkappaB
stoichiometric coefficient: 1.0

NRAS isoform 1
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot H2PZQ7 1400
organism: Pan troglodytes

uniprot H2QL58 1206
type: UnificationXref
id: H2QL58
db: uniprot

UNKNOWN_TRANSITION_LEFT__Complex__Galphai_q__GTP_-RIGHT__Complex__Galphaq_GTP_-_r7
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 1789
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 1788
left: Complex (Galphai/q/ GTP)
interaction type: UNKNOWN_TRANSITION
right: Complex (Galphaq/GTP)

uniprot F7BZM9 1573
type: UnificationXref
id: F7BZM9
db: uniprot

uniprot H2RBJ1 1583
type: UnificationXref
id: H2RBJ1
db: uniprot

uniprot F1P1K3 1565
type: UnificationXref
id: F1P1K3
db: uniprot

IkappaB s204 a296 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_ANGLE=4.25
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Myosin heavy chain 6
type: ProteinReference
xref: PTHR45615:SF11
xref: uniprot F1N2G0 1276
organism: Bos taurus

uniprot Q5BK52 1176
type: UnificationXref
id: Q5BK52
db: uniprot

PTHR11937:SF421
type: RelationshipXref
id: PTHR11937:SF421
db: PANTHER Family
relationship type: By Homology

C-C chemokine receptor type 2
type: ProteinReference
xref: uniprot O18793 700
organism: Macaca mulatta

uniprot H2QMA4 645
type: UnificationXref
id: H2QMA4
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q63844 296
organism: Mus musculus

PTHR11937:SF423
type: RelationshipXref
id: PTHR11937:SF423
db: PANTHER Family
relationship type: By Homology

Actin-related protein 2/3 complex subunit 5-like protein
type: ProteinReference
xref: uniprot Q9D898 1634
organism: Mus musculus

PTHR11937:SF416
type: RelationshipXref
id: PTHR11937:SF416
db: PANTHER Family
relationship type: By Homology

uniprot V5IKE7 307
type: UnificationXref
id: V5IKE7
db: uniprot

PTK2B isoform 2
type: ProteinReference
xref: uniprot H2QVX8 631
xref: PTHR24418:SF94
organism: Pan troglodytes

Myosin heavy chain 11
type: ProteinReference
xref: PTHR45615:SF23
xref: uniprot F6WFN3 1292
organism: Ornithorhynchus anatinus

IkappaB s204 a296 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: uniprot G3V926 1420
organism: Rattus norvegicus

uniprot A8Y4Q9 910
type: UnificationXref
id: A8Y4Q9
db: uniprot

Sos
type: Protein
entity reference: Sos
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa36 1745
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9913 14
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot E2QWU0 1562
type: UnificationXref
id: E2QWU0
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6Z9H7 401
organism: Macaca mulatta

uniprot F6WH53 545
type: UnificationXref
id: F6WH53
db: uniprot

Mitogen-activated protein kinase FUS3
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot P16892 278
organism: Saccharomyces cerevisiae

uniprot P25930 715
type: UnificationXref
id: P25930
db: uniprot

uniprot P42338 1383
type: UnificationXref
id: P42338
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot A0A2I3SSC7 481
organism: Pan troglodytes

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot J9NTI3 1584
organism: Canis lupus familiaris

CHKR
type: Protein
entity reference: CHKR
feature: COMPLEX PARTICIPANT BINDING FEATURE s207 sa10 1711
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot E1C3P6 390
organism: Gallus gallus

uniprot F7AQR3 18
type: UnificationXref
id: F7AQR3
db: uniprot

Arachidonate 5-lipoxygenase-activating protein (Fragment)
type: ProteinReference
xref: uniprot P30354 137
xref: PTHR10250:SF2
organism: Macaca mulatta

Arachidonate 5-lipoxygenase-activating protein
type: ProteinReference
xref: uniprot P30355 138
xref: PTHR10250:SF2
organism: Mus musculus

uniprot P51684 741
type: UnificationXref
id: P51684
db: uniprot

uniprot P79255 857
type: UnificationXref
id: P79255
db: uniprot

Formyl peptide receptor,-related sequence 3
type: ProteinReference
xref: uniprot D3ZX41 665
organism: Rattus norvegicus

Complex (Galphai/GTP)
type: Complex
component stoichiometry: Galphai s18 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s20 sa15 STOICHIOMETRY ID COMPLEX
component: Galphai
component: GTP
feature: COMPLEX BINDING FEATURE s34 a59 1718
feature: COMPLEX BINDING FEATURE s34 a59 1720
cellular location: cytoplasm

uniprot Q61016 372
type: UnificationXref
id: Q61016
db: uniprot

PTHR10845:SF196
type: RelationshipXref
id: PTHR10845:SF196
db: PANTHER Family
relationship type: By Homology

uniprot P35579 1325
type: UnificationXref
id: P35579
db: uniprot

uniprot F6VVA6 1464
type: UnificationXref
id: F6VVA6
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F7BWW9 599
xref: PTHR23113:SF168
organism: Ornithorhynchus anatinus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
type: ProteinReference
xref: uniprot Q4KWH5 1508
organism: Mus musculus

uniprot P04275 1209
type: UnificationXref
id: P04275
db: uniprot

uniprot H9ERR5 1477
type: UnificationXref
id: H9ERR5
db: uniprot

uniprot P48346 1411
type: UnificationXref
id: P48346
db: uniprot

C-C chemokine receptor type 1
type: ProteinReference
xref: uniprot F6QJR2 673
organism: Macaca mulatta

PTHR46037:SF3
type: RelationshipXref
id: PTHR46037:SF3
db: PANTHER Family
relationship type: By Homology

uniprot H2RA86 274
type: UnificationXref
id: H2RA86
db: uniprot

PTHR46037:SF4
type: RelationshipXref
id: PTHR46037:SF4
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot Q9JID2 45
organism: Rattus norvegicus

uniprot Q3Y3Z2 1174
type: UnificationXref
id: Q3Y3Z2
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: uniprot Q62077 1510
xref: PTHR10336:SF173
organism: Mus musculus

uniprot A0A2I3SCU5 636
type: UnificationXref
id: A0A2I3SCU5
db: uniprot

uniprot F6U5C5 434
type: UnificationXref
id: F6U5C5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RJ76 627
xref: PTHR24418:SF94
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2RA86 274
xref: PTHR24055:SF393
organism: Pan troglodytes

PTHR46037:SF2
type: RelationshipXref
id: PTHR46037:SF2
db: PANTHER Family
relationship type: By Homology

PTHR10845:SF184
type: RelationshipXref
id: PTHR10845:SF184
db: PANTHER Family
relationship type: By Homology

uniprot Q9DC51 118
type: UnificationXref
id: Q9DC51
db: uniprot

uniprot P21730 711
type: UnificationXref
id: P21730
db: uniprot

G protein subunit alpha i2
type: ProteinReference
xref: uniprot H2QMN4 96
organism: Pan troglodytes

uniprot P60010 1013
type: UnificationXref
id: P60010
db: uniprot

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot P63259 1023
organism: Rattus norvegicus

uniprot Q55EU6 1052
type: UnificationXref
id: Q55EU6
db: uniprot

uniprot F7HQD8 1202
type: UnificationXref
id: F7HQD8
db: uniprot

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot P63258 1022
organism: Bos taurus

uniprot Q9QY78 1428
type: UnificationXref
id: Q9QY78
db: uniprot

Actin-87E
type: ProteinReference
xref: uniprot P10981 997
xref: PTHR11937:SF397
organism: Drosophila melanogaster

PTHR10489:SF916
type: RelationshipXref
id: PTHR10489:SF916
db: PANTHER Family
relationship type: By Homology

Actin-3
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P0DM42 996
organism: Caenorhabditis elegans

Actin-2
type: ProteinReference
xref: PTHR11937:SF470
xref: uniprot P10984 998
organism: Caenorhabditis elegans

uniprot O96622 1594
type: UnificationXref
id: O96622
db: uniprot

uniprot P10688 1487
type: UnificationXref
id: P10688
db: uniprot

uniprot P63259 1023
type: UnificationXref
id: P63259
db: uniprot

Myosin-9
type: ProteinReference
xref: uniprot Q8VDD5 1344
xref: PTHR45615:SF16
organism: Mus musculus

Arachidonate 5-lipoxygenase-activating protein
type: ProteinReference
xref: PTHR10250:SF2
xref: uniprot P20292 135
organism: Homo sapiens

Arachidonate 5-lipoxygenase-activating protein
type: ProteinReference
xref: uniprot P20291 134
xref: PTHR10250:SF2
organism: Rattus norvegicus

Cell division control protein 42 homolog isoform 2
type: ProteinReference
xref: uniprot F6RBZ7 199
xref: PTHR24072:SF337
organism: Macaca mulatta

DISSOCIATION
type: RelationshipTypeVocabulary

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: uniprot P63267 1026
xref: PTHR11937:SF445
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR22829:SF6
xref: uniprot F6WVV6 1538
organism: Macaca mulatta

uniprot P27638 281
type: UnificationXref
id: P27638
db: uniprot

uniprot P79191 752
type: UnificationXref
id: P79191
db: uniprot

uniprot P47712 793
type: UnificationXref
id: P47712
db: uniprot

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot P63261 1025
organism: Homo sapiens

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot P63260 1024
organism: Mus musculus

uniprot Q69ZK0 1546
type: UnificationXref
id: Q69ZK0
db: uniprot

uniprot E2RMC0 485
type: UnificationXref
id: E2RMC0
db: uniprot

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot P63268 1027
organism: Mus musculus

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot K7CBH8 1134
xref: PTHR24356:SF159
organism: Pan troglodytes

uniprot A0A2I3T9Y4 47
type: UnificationXref
id: A0A2I3T9Y4
db: uniprot

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot P63269 1028
organism: Rattus norvegicus

uniprot F1PDD9 613
type: UnificationXref
id: F1PDD9
db: uniprot

PARTICIPANT STOICHIOMETRY re69 1869
type: Stoichiometry
physical entity: a296_degraded
stoichiometric coefficient: 1.0

GDP s4 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot P11881 496
type: UnificationXref
id: P11881
db: uniprot

STATE_TRANSITION_LEFT__SrcPTK-RIGHT__SrcPTK-_r11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 1819
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 1820
left: SrcPTK
interaction type: STATE_TRANSITION
right: SrcPTK

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NFAT-RIGHT__NFAT-_r51
controller: CaMK

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: uniprot P63270 1029
xref: PTHR11937:SF445
organism: Gallus gallus

uniprot A0A1D5Q4K0 1188
type: UnificationXref
id: A0A1D5Q4K0
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot F1PT97 1566
xref: PTHR10709:SF11
organism: Canis lupus familiaris

STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 1895
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 1894
left: IP3R
interaction type: STATE_TRANSITION
right: IP3R

PARTICIPANT STOICHIOMETRY re69 1868
type: Stoichiometry
physical entity: IkappaB
stoichiometric coefficient: 1.0

uniprot P51681 738
type: UnificationXref
id: P51681
db: uniprot

Evidence 508
type: Evidence
evidence code: ISS
comment: SPACC P11345

Evidence 509
type: Evidence
evidence code: ISS
comment: SPACC Q99N57

Evidence 506
type: Evidence
evidence code: ISS
comment: SPACC P04049

Evidence 507
type: Evidence
evidence code: ISS
comment: SPACC P05625

uniprot F1MY55 395
type: UnificationXref
id: F1MY55
db: uniprot

uniprot Q7TQN4 1112
type: UnificationXref
id: Q7TQN4
db: uniprot

C-X-C chemokine receptor type 4
type: ProteinReference
xref: uniprot Q07FZ4 758
xref: PTHR10489:SF594
organism: Xenopus tropicalis

Nuclear factor of activated T cells 2
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot F1PDD9 613
organism: Canis lupus familiaris

uniprot O14512 1681
type: UnificationXref
id: O14512
db: uniprot

Inactive phospholipase C-like protein 2
type: ProteinReference
xref: uniprot Q8K394 1517
organism: Mus musculus

uniprot Q39022 289
type: UnificationXref
id: Q39022
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPK-RIGHT__MAPK-_r77
controller: MEK

uniprot H2Q597 1204
type: UnificationXref
id: H2Q597
db: uniprot

PARTICIPANT STOICHIOMETRY r41 1828
type: Stoichiometry
physical entity: Integrin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r41 1829
type: Stoichiometry
physical entity: Complex (Integrin/EMC)
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot A3KGF7 1443
organism: Mus musculus

uniprot A0A1D5RJQ0 605
type: UnificationXref
id: A0A1D5RJQ0
db: uniprot

uniprot F1NT98 589
type: UnificationXref
id: F1NT98
db: uniprot

C-X-C chemokine receptor type 3
type: ProteinReference
xref: uniprot Q9JII9 774
xref: PTHR10489:SF671
organism: Rattus norvegicus

Inhibitor of nuclear factor kappa B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot H2QW34 1421
organism: Pan troglodytes

PTHR22969:SF7
type: RelationshipXref
id: PTHR22969:SF7
db: PANTHER Family
relationship type: By Homology

uniprot P47774 729
type: UnificationXref
id: P47774
db: uniprot

PTHR19850:SF31
type: RelationshipXref
id: PTHR19850:SF31
db: PANTHER Family
relationship type: By Homology

ncbitaxon 6239 71
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot Q62401 869
type: UnificationXref
id: Q62401
db: uniprot

PARTICIPANT STOICHIOMETRY r41 1827
type: Stoichiometry
physical entity: EMC
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot A0A3Q2U4X3 49
organism: Gallus gallus

Actin, beta like 2
type: ProteinReference
xref: uniprot H2QE24 983
xref: PTHR11937:SF278
organism: Pan troglodytes

Rho-associated protein kinase 1
type: ProteinReference
xref: PTHR22988:SF33
xref: uniprot P70335 1691
organism: Mus musculus

Actin-5C
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P10987 1000
organism: Drosophila melanogaster

uniprot A0A2I3T8F7 1439
type: UnificationXref
id: A0A2I3T8F7
db: uniprot

Actin-4
type: ProteinReference
xref: PTHR11937:SF471
xref: uniprot P10986 999
organism: Caenorhabditis elegans

CHK s208 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHK
stoichiometric coefficient: 1.0

PTHR13809:SF5
type: RelationshipXref
id: PTHR13809:SF5
db: PANTHER Family
relationship type: By Homology

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P10989 1001
organism: Schizosaccharomyces pombe

uniprot H2PXY8 1374
type: UnificationXref
id: H2PXY8
db: uniprot

PTHR44329:SF22
type: RelationshipXref
id: PTHR44329:SF22
db: PANTHER Family
relationship type: By Homology

Regulator of G-protein signaling 17 (Predicted), isoform CRA_a
type: ProteinReference
xref: PTHR10845:SF196
xref: uniprot F1M0G0 167
organism: Rattus norvegicus

Complex (CHKR/CHK/ Galphai/q/ GDP/Gbetagamma)
type: Complex
component stoichiometry: Gbetagamma s12 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: CHK s7 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s11 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: Galphai q s8 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: CHKR s6 sa5 STOICHIOMETRY ID COMPLEX
component: CHKR
component: Gbetagamma
component: GDP
component: Galphai/q
component: CHK
feature: COMPLEX BINDING FEATURE s19 a26 1726
feature: COMPLEX BINDING FEATURE s19 a26 1730
feature: COMPLEX BINDING FEATURE s19 a26 1724
feature: COMPLEX BINDING FEATURE s19 a26 1722
feature: COMPLEX BINDING FEATURE s19 a26 1728
cellular location: cytoplasm

Formyl peptide receptor-related sequence 4
type: ProteinReference
xref: uniprot A4FUQ5 663
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63219 367
xref: PTHR13809:SF5
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 366
xref: PTHR13809:SF5
organism: Homo sapiens

uniprot F6ZFI9 202
type: UnificationXref
id: F6ZFI9
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot P63217 365
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63216 364
xref: PTHR13809:SF11
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 363
xref: PTHR13809:SF11
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63214 362
xref: PTHR13809:SF11
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: PTHR13809:SF25
xref: uniprot P63213 361
organism: Mus musculus

uniprot P52287 356
type: UnificationXref
id: P52287
db: uniprot

uniprot H2Q1D9 340
type: UnificationXref
id: H2Q1D9
db: uniprot

uniprot Q9JID2 45
type: UnificationXref
id: Q9JID2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A0A2A6CRA8 890
organism: Pristionchus pacificus

uniprot F6PNT9 642
type: UnificationXref
id: F6PNT9
db: uniprot

uniprot Q07889 601
type: UnificationXref
id: Q07889
db: uniprot

uniprot A2G1K5 893
type: UnificationXref
id: A2G1K5
db: uniprot

uniprot P16050 132
type: UnificationXref
id: P16050
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E9GYE9 194
organism: Daphnia pulex

uniprot F6Z9H7 401
type: UnificationXref
id: F6Z9H7
db: uniprot

uniprot O88643 410
type: UnificationXref
id: O88643
db: uniprot

uniprot Q04863 1109
type: UnificationXref
id: Q04863
db: uniprot

uniprot Q6IQX1 1339
type: UnificationXref
id: Q6IQX1
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6ZKL2 1466
xref: PTHR10336:SF12
organism: Macaca mulatta

uniprot D3ZQF9 126
type: UnificationXref
id: D3ZQF9
db: uniprot

Suppressor of cytokine-signaling 7
type: ProteinReference
xref: PTHR10155:SF5
xref: uniprot A0A0G2K9S1 1665
organism: Rattus norvegicus

uniprot Q9P218 1225
type: UnificationXref
id: Q9P218
db: uniprot

PARTICIPANT STOICHIOMETRY re68 1872
type: Stoichiometry
physical entity: IkappaB
stoichiometric coefficient: 1.0

uniprot F7BWW9 599
type: UnificationXref
id: F7BWW9
db: uniprot

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: uniprot P59215 106
organism: Rattus norvegicus

Rac family small GTPase 1b
type: ProteinReference
xref: uniprot Q29RC5 242
organism: Danio rerio

PARTICIPANT STOICHIOMETRY re68 1873
type: Stoichiometry
physical entity: IkappaB
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot E2RGI5 314
organism: Canis lupus familiaris

Beta-actin-like protein 2
type: ProteinReference
xref: uniprot Q8BFZ3 1077
xref: PTHR11937:SF168
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
type: ProteinReference
xref: uniprot Q62711 1512
organism: Rattus norvegicus

AP-1
type: Protein
entity reference: AP-1
feature: ACTIVE 46
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Myosin-9
type: ProteinReference
xref: uniprot Q62812 1338
xref: PTHR45615:SF16
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF446
xref: uniprot C3ZTX6 943
organism: Branchiostoma floridae

IkappaB
type: Protein
entity reference: IkappaB
feature: IkappaB s200 a133 rs2
feature: IkappaB s200 a133 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR10845:SF32
xref: uniprot F7G3M7 169
organism: Macaca mulatta

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7GEK1 62
xref: PTHR24356:SF190
organism: Monodelphis domestica

C-C chemokine receptor type 4
type: ProteinReference
xref: PTHR10489:SF608
xref: uniprot P51680 737
organism: Mus musculus

uniprot F7G5G3 1647
type: UnificationXref
id: F7G5G3
db: uniprot

C-C chemokine receptor type 2
type: ProteinReference
xref: PTHR10489:SF928
xref: uniprot P51683 740
organism: Mus musculus

Myosin-IIIa
type: ProteinReference
xref: uniprot Q8NEV4 1343
organism: Homo sapiens

C-C chemokine receptor type 6
type: ProteinReference
xref: PTHR10489:SF611
xref: uniprot P51684 741
organism: Homo sapiens

C-C chemokine receptor type 5
type: ProteinReference
xref: uniprot P51681 738
organism: Homo sapiens

C-C chemokine receptor type 5
type: ProteinReference
xref: uniprot P51682 739
organism: Mus musculus

C-C chemokine receptor type 3
type: ProteinReference
xref: uniprot P51677 734
xref: PTHR10489:SF649
organism: Homo sapiens

C-C chemokine receptor 1-like protein 1
type: ProteinReference
xref: uniprot P51676 733
organism: Mus musculus

C-C chemokine receptor type 1
type: ProteinReference
xref: PTHR10489:SF711
xref: uniprot P51675 732
organism: Mus musculus

C-C chemokine receptor type 4
type: ProteinReference
xref: PTHR10489:SF608
xref: uniprot P51679 736
organism: Homo sapiens

uniprot J9NTI3 1584
type: UnificationXref
id: J9NTI3
db: uniprot

uniprot O15111 1423
type: UnificationXref
id: O15111
db: uniprot

Probable C-C chemokine receptor type 3
type: ProteinReference
xref: uniprot P51678 735
organism: Mus musculus

Transcription factor AP-1
type: ProteinReference
xref: uniprot P18870 446
xref: PTHR11462:SF8
organism: Gallus gallus

PTHR12305:SF81
type: RelationshipXref
id: PTHR12305:SF81
db: PANTHER Family
relationship type: By Homology

Vav guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot E2RGT8 1536
xref: PTHR45818:SF2
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: uniprot P18872 104
organism: Mus musculus

AP-1
type: Protein
entity reference: AP-1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

RELB proto-oncogene, NF-kB subunit
type: ProteinReference
xref: uniprot F1MBB0 1097
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot F6SD46 1460
organism: Monodelphis domestica

MEK
type: ProteinReference
xref: P00864
standard name: Mitogen-activated protein kinase kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.MEK
comment: ENTITY_REFERENCE_NOTES=Long Name: MAP kinase/Erk kinase kinase Synonym: MAP kinase kinase,MAPKK,Mitogen-activated protein kinase kinase Accession: P00864
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase kinase kinase 7
member entity reference: Mitogen-activated protein kinase kinase kinase 4

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: uniprot Q62829 420
xref: PTHR48015:SF30
organism: Rattus norvegicus

C-C chemokine receptor type 9
type: ProteinReference
xref: uniprot P51686 743
xref: PTHR10489:SF664
organism: Homo sapiens

C-C chemokine receptor type 8
type: ProteinReference
xref: PTHR10489:SF627
xref: uniprot P51685 742
organism: Homo sapiens

uniprot F1MWV6 1672
type: UnificationXref
id: F1MWV6
db: uniprot

uniprot F6SSS3 319
type: UnificationXref
id: F6SSS3
db: uniprot

uniprot A0A2I3T6U4 1393
type: UnificationXref
id: A0A2I3T6U4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11462:SF7
xref: uniprot F6T6T3 433
organism: Ornithorhynchus anatinus

uniprot A0A1W2WEN5 888
type: UnificationXref
id: A0A1W2WEN5
db: uniprot

uniprot Q9Y7J4 1644
type: UnificationXref
id: Q9Y7J4
db: uniprot

uniprot P48298 846
type: UnificationXref
id: P48298
db: uniprot

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 191

uniprot Q0IPW3 1044
type: UnificationXref
id: Q0IPW3
db: uniprot

LTB4R2 isoform 2
type: ProteinReference
xref: uniprot H2RDU2 692
xref: PTHR24230:SF8
organism: Pan troglodytes

uniprot F1MBB0 1097
type: UnificationXref
id: F1MBB0
db: uniprot

uniprot O88536 706
type: UnificationXref
id: O88536
db: uniprot

PTHR47633:SF1
type: RelationshipXref
id: PTHR47633:SF1
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EZT2 92
organism: Macaca mulatta

uniprot Q63953 1245
type: UnificationXref
id: Q63953
db: uniprot

uniprot A0A0G2K6E0 1115
type: UnificationXref
id: A0A0G2K6E0
db: uniprot

PARTICIPANT STOICHIOMETRY r79 1803
type: Stoichiometry
physical entity: Prostaglandin
stoichiometric coefficient: 1.0

PYK2
type: ProteinReference
xref: P00852
standard name: Proline-rich tyrosine kinase 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.PYK2
comment: ENTITY_REFERENCE_NOTES=Long Name: Proline-rich tyrosine kinase 2 Synonym: PYK2 Accession: P00852
member entity reference: Protein tyrosine kinase 2 beta
member entity reference: PTK2B isoform 2
member entity reference: Uncharacterized protein
member entity reference: Protein-tyrosine kinase 2-beta

uniprot P80098 859
type: UnificationXref
id: P80098
db: uniprot

uniprot O95837 26
type: UnificationXref
id: O95837
db: uniprot

uniprot F7GVU6 1100
type: UnificationXref
id: F7GVU6
db: uniprot

Probable actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot P91167 1609
organism: Caenorhabditis elegans

Protein ras-1
type: ProteinReference
xref: uniprot P22126 1407
xref: PTHR24070:SF17
organism: Neurospora crassa

Calcium/calmodulin-dependent protein kinase type II alpha chain
type: ProteinReference
xref: PTHR24347:SF412
xref: uniprot Q00168 572
organism: Drosophila melanogaster

uniprot F6W7C8 1366
type: UnificationXref
id: F6W7C8
db: uniprot

Galphai
type: ProteinReference
xref: P00828
standard name: Gi-protein, alpha subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.G_alpha__sub_i
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Uncharacterized protein
member entity reference: G protein subunit alpha o1
member entity reference: Gnai3 protein
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-2
member entity reference: Guanine nucleotide-binding protein G(K) subunit alpha
member entity reference: Guanine nucleotide-binding protein alpha-1 subunit
member entity reference: G protein subunit alpha i1
member entity reference: Guanine nucleotide-binding protein G(k) subunit alpha
member entity reference: Guanine nucleotide-binding protein alpha subunit
member entity reference: G protein subunit alpha i2
member entity reference: Guanine nucleotide-binding protein G(O) subunit alpha isoform a
member entity reference: Guanine nucleotide-binding protein subunit alpha
member entity reference: G-alpha subunit
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
member entity reference: Guanine nucleotide-binding protein G(o) subunit alpha
member entity reference: G protein subunit alpha i3
member entity reference: Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1

STATE_TRANSITION_LEFT__IkappaB-RIGHT__IkappaB-_re68
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re68 1873
participant stoichiometry: PARTICIPANT STOICHIOMETRY re68 1872
left: IkappaB
interaction type: STATE_TRANSITION
right: IkappaB

C-C chemokine receptor type 10
type: ProteinReference
xref: uniprot P46092 727
xref: PTHR10489:SF773
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r79 1802
type: Stoichiometry
physical entity: Arachidonic acid
stoichiometric coefficient: 1.0

uniprot A7RRG4 1553
type: UnificationXref
id: A7RRG4
db: uniprot

Chemokine XC receptor 1
type: ProteinReference
xref: uniprot P46094 728
organism: Homo sapiens

cAMP-dependent protein kinase type 3
type: ProteinReference
xref: uniprot P05986 1159
xref: PTHR24353:SF73
organism: Saccharomyces cerevisiae

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1MY55 395
organism: Bos taurus

Prostaglandin
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR13809:SF6
type: RelationshipXref
id: PTHR13809:SF6
db: PANTHER Family
relationship type: By Homology

PTHR13809:SF9
type: RelationshipXref
id: PTHR13809:SF9
db: PANTHER Family
relationship type: By Homology

PTHR13809:SF8
type: RelationshipXref
id: PTHR13809:SF8
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot F6SCP4 963
organism: Ciona intestinalis

Uncharacterized protein
type: ProteinReference
xref: PTHR10845:SF184
xref: uniprot F7CYN6 168
organism: Macaca mulatta

GRB2-related adaptor protein 2
type: ProteinReference
xref: PTHR46037:SF3
xref: uniprot O89100 583
organism: Mus musculus

EMC s26 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EMC
stoichiometric coefficient: 1.0

uniprot H2QX70 816
type: UnificationXref
id: H2QX70
db: uniprot

uniprot Q5ZJI7 1622
type: UnificationXref
id: Q5ZJI7
db: uniprot

uniprot E9HGF5 950
type: UnificationXref
id: E9HGF5
db: uniprot

IP3
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F7G3I5 1371
organism: Monodelphis domestica

uniprot Q3ZCA7 115
type: UnificationXref
id: Q3ZCA7
db: uniprot

PTHR24055:SF466
type: RelationshipXref
id: PTHR24055:SF466
db: PANTHER Family
relationship type: By Homology

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot F6R543 488
xref: PTHR13715:SF51
organism: Monodelphis domestica

Platelet-activating factor receptor
type: ProteinReference
xref: uniprot Q62035 766
xref: PTHR24233:SF6
organism: Mus musculus

uniprot P10855 835
type: UnificationXref
id: P10855
db: uniprot

SHC (Src homology 2 domain containing) transforming protein 1
type: ProteinReference
xref: uniprot H2R8L2 1233
xref: PTHR10337:SF2
organism: Pan troglodytes

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P08752 99
organism: Mus musculus

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot P08754 101
organism: Homo sapiens

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot P08753 100
organism: Rattus norvegicus

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot A0A3Q1M353 511
organism: Bos taurus

uniprot Q84UI5 301
type: UnificationXref
id: Q84UI5
db: uniprot

uniprot F7F580 334
type: UnificationXref
id: F7F580
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot E1BBJ7 450
organism: Bos taurus

uniprot Q92747 1630
type: UnificationXref
id: Q92747
db: uniprot

uniprot H2R8C2 689
type: UnificationXref
id: H2R8C2
db: uniprot

PARTICIPANT STOICHIOMETRY r35 1844
type: Stoichiometry
physical entity: ROCK
stoichiometric coefficient: 1.0

Arachidonate 12-lipoxygenase, 12S-type
type: ProteinReference
xref: PTHR11771:SF4
xref: uniprot P18054 133
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r35 1845
type: Stoichiometry
physical entity: ROCK
stoichiometric coefficient: 1.0

uniprot Q9TV16 780
type: UnificationXref
id: Q9TV16
db: uniprot

ncbitaxon 5786 197
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot F7G2Y1 1690
type: UnificationXref
id: F7G2Y1
db: uniprot

uniprot A0A2I3TRC4 9
type: UnificationXref
id: A0A2I3TRC4
db: uniprot

RHOA isoform 2
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot H2QML4 1119
organism: Pan troglodytes

Cytokine receptor
type: Complex
component stoichiometry: Cytokine receptor s30 sa20 STOICHIOMETRY ID COMPLEX
component: Cytokine receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa20 1757
feature: ACTIVE 46
cellular location: cytoplasm

uniprot A8WS32 906
type: UnificationXref
id: A8WS32
db: uniprot

uniprot D3ZUL3 1191
type: UnificationXref
id: D3ZUL3
db: uniprot

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Sos-_Shc-_Grb-RIGHT__Complex__Shc_Sos__Grb_-_r69
controller: Complex (Cytokine receptor/JAK/ JAK/IL2)

uniprot Q6DEH3 579
type: UnificationXref
id: Q6DEH3
db: uniprot

ncbitaxon 5664 1085
type: UnificationXref
id: 5664
db: ncbitaxon

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 276

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GEF-RIGHT__GEF-_r30
controller: PIP3

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF217
xref: uniprot F1N2V3 15
organism: Bos taurus

uniprot O96625 1597
type: UnificationXref
id: O96625
db: uniprot

GEF
type: Protein
entity reference: GEF
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q8BFZ3 1077
type: UnificationXref
id: Q8BFZ3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLCbetagamma-RIGHT__PLCbetagamma-_r21
controller: Gbetagamma

Nuclear factor kappa B subunit 2
type: ProteinReference
xref: uniprot Q5U2Z4 1110
xref: PTHR24169:SF21
organism: Rattus norvegicus

Actin beta
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot F6UDX9 968
organism: Ornithorhynchus anatinus

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P21708 279
xref: PTHR24055:SF393
organism: Rattus norvegicus

uniprot Q75HX0 1072
type: UnificationXref
id: Q75HX0
db: uniprot

G protein subunit gamma 5
type: ProteinReference
xref: PTHR13809:SF51
xref: uniprot H2PZA6 339
organism: Pan troglodytes

Eotaxin
type: ProteinReference
xref: uniprot P51671 851
organism: Homo sapiens

uniprot F6V946 515
type: UnificationXref
id: F6V946
db: uniprot

uniprot P16892 278
type: UnificationXref
id: P16892
db: uniprot

C-X-C chemokine receptor type 2 (Fragment)
type: ProteinReference
xref: uniprot Q28519 760
xref: PTHR10489:SF689
organism: Macaca mulatta

Cish protein
type: ProteinReference
xref: PTHR10155:SF9
xref: uniprot B1WBX9 1666
organism: Rattus norvegicus

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot F7FN72 1576
xref: PTHR12391:SF0
organism: Ornithorhynchus anatinus

Trichomonas vaginalis
type: BioSource
xref: ncbitaxon 5722 892

STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_r29
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 1871
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 1870
left: AKT
interaction type: STATE_TRANSITION
right: AKT

uniprot A3C6D7 895
type: UnificationXref
id: A3C6D7
db: uniprot

GEF
type: Protein
entity reference: GEF
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Danio rerio
type: BioSource
xref: ncbitaxon 7955 12

uniprot P59215 106
type: UnificationXref
id: P59215
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot A0A1D5Q7K7 887
organism: Macaca mulatta

PTHR24055:SF438
type: RelationshipXref
id: PTHR24055:SF438
db: PANTHER Family
relationship type: By Homology

uniprot P41324 845
type: UnificationXref
id: P41324
db: uniprot

PTHR24055:SF439
type: RelationshipXref
id: PTHR24055:SF439
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein alpha-1 subunit
type: ProteinReference
xref: uniprot Q05425 111
organism: Neurospora crassa

uniprot F7H6T2 1149
type: UnificationXref
id: F7H6T2
db: uniprot

uniprot F6SW23 1364
type: UnificationXref
id: F6SW23
db: uniprot

STATE_TRANSITION_LEFT__PAK-RIGHT__PAK-_r36
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 1843
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 1842
left: PAK
interaction type: STATE_TRANSITION
right: PAK

uniprot Q95KV1 1427
type: UnificationXref
id: Q95KV1
db: uniprot

uniprot Q63746 884
type: UnificationXref
id: Q63746
db: uniprot

Nuclear factor of activated T cells 5
type: ProteinReference
xref: uniprot F1MAZ9 610
organism: Bos taurus

uniprot P60484 594
type: UnificationXref
id: P60484
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot E1BKE7 484
organism: Bos taurus

Collagen alpha-1(XIV) chain
type: ProteinReference
xref: PTHR24020:SF15
xref: uniprot A0A1D5P0F4 1187
organism: Gallus gallus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot D4A5Q1 1359
xref: PTHR10048:SF35
organism: Rattus norvegicus

ITGA9 isoform 2
type: ProteinReference
xref: PTHR23220:SF69
xref: uniprot H2QMA4 645
organism: Pan troglodytes

PTHR46680:SF1
type: RelationshipXref
id: PTHR46680:SF1
db: PANTHER Family
relationship type: By Homology

Non-muscle actin 6.2
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot B3RX77 923
organism: Trichoplax adhaerens

PTHR22588:SF5
type: RelationshipXref
id: PTHR22588:SF5
db: PANTHER Family
relationship type: By Homology

C5a anaphylatoxin chemotactic receptor 1
type: ProteinReference
xref: PTHR24225:SF29
xref: uniprot P21730 711
organism: Homo sapiens

uniprot P09055 649
type: UnificationXref
id: P09055
db: uniprot

Actin (Fragment)
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A2HNG1 894
organism: Trichomonas vaginalis

PTHR11937:SF483
type: RelationshipXref
id: PTHR11937:SF483
db: PANTHER Family
relationship type: By Homology

uniprot F7DZJ9 616
type: UnificationXref
id: F7DZJ9
db: uniprot

uniprot A0A2I3RKA2 1252
type: UnificationXref
id: A0A2I3RKA2
db: uniprot

uniprot Q04982 529
type: UnificationXref
id: Q04982
db: uniprot

Sos
type: Protein
entity reference: Sos
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P05986 1159
type: UnificationXref
id: P05986
db: uniprot

uniprot A0A2I3T5A0 1549
type: UnificationXref
id: A0A2I3T5A0
db: uniprot

C-C motif chemokine 8
type: ProteinReference
xref: uniprot Q09141 865
organism: Bos taurus

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot O18840 986
organism: Canis lupus familiaris

Mitogen-activated protein kinase 5
type: ProteinReference
xref: uniprot Q10N20 286
xref: PTHR24055:SF391
organism: Oryza sativa

C-X-C chemokine receptor type 4
type: ProteinReference
xref: PTHR10489:SF594
xref: uniprot P79394 756
organism: Macaca mulatta

uniprot F7D5G3 1468
type: UnificationXref
id: F7D5G3
db: uniprot

uniprot O88430 825
type: UnificationXref
id: O88430
db: uniprot

uniprot Q39033 1506
type: UnificationXref
id: Q39033
db: uniprot

uniprot P11730 569
type: UnificationXref
id: P11730
db: uniprot

uniprot P04627 521
type: UnificationXref
id: P04627
db: uniprot

Transcription factor jun-B
type: ProteinReference
xref: PTHR11462:SF37
xref: uniprot P09450 440
organism: Mus musculus

uniprot F1MKG2 1197
type: UnificationXref
id: F1MKG2
db: uniprot

uniprot Q2YEG0 762
type: UnificationXref
id: Q2YEG0
db: uniprot

PTHR45615:SF6
type: RelationshipXref
id: PTHR45615:SF6
db: PANTHER Family
relationship type: By Homology

PTHR45615:SF1
type: RelationshipXref
id: PTHR45615:SF1
db: PANTHER Family
relationship type: By Homology

Transcription factor jun-D
type: ProteinReference
xref: PTHR11462:SF7
xref: uniprot P15066 441
organism: Mus musculus

C-C motif chemokine
type: ProteinReference
xref: uniprot H2RDM0 820
organism: Pan troglodytes

PTHR45615:SF2
type: RelationshipXref
id: PTHR45615:SF2
db: PANTHER Family
relationship type: By Homology

PTHR45615:SF3
type: RelationshipXref
id: PTHR45615:SF3
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF468
type: RelationshipXref
id: PTHR11937:SF468
db: PANTHER Family
relationship type: By Homology

von Willebrand factor A domain-containing protein 2
type: ProteinReference
xref: PTHR24020:SF37
xref: uniprot Q70UZ7 1221
organism: Mus musculus

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot F7EQH3 1575
organism: Monodelphis domestica

PTHR11937:SF469
type: RelationshipXref
id: PTHR11937:SF469
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5QG31 5
type: UnificationXref
id: A0A1D5QG31
db: uniprot

uniprot P22612 1164
type: UnificationXref
id: P22612
db: uniprot

PTHR11937:SF464
type: RelationshipXref
id: PTHR11937:SF464
db: PANTHER Family
relationship type: By Homology

uniprot A7SEA7 901
type: UnificationXref
id: A7SEA7
db: uniprot

Cytokine receptor
type: Complex
component stoichiometry: Cytokine receptor s55 sa26 STOICHIOMETRY ID COMPLEX
component: Cytokine receptor
feature: ACTIVE 46
feature: COMPLEX PARTICIPANT BINDING FEATURE s55 sa26 1695
cellular location: cytoplasm

G protein-coupled receptor kinase 6
type: ProteinReference
xref: PTHR24355:SF15
xref: uniprot P97711 462
organism: Rattus norvegicus

uniprot Q7JWS8 251
type: UnificationXref
id: Q7JWS8
db: uniprot

Cytokine receptor
type: Complex
component stoichiometry: Cytokine receptor s32 sa22 STOICHIOMETRY ID COMPLEX
component: Cytokine receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa22 1769
feature: ACTIVE 46
cellular location: cytoplasm

uniprot A0A1D5Q7K7 887
type: UnificationXref
id: A0A1D5Q7K7
db: uniprot

uniprot Q39024 291
type: UnificationXref
id: Q39024
db: uniprot

Myosin light chain kinase 2, skeletal/cardiac muscle
type: ProteinReference
xref: PTHR24347:SF373
xref: uniprot Q8VCR8 1656
organism: Mus musculus

uniprot Q8VHQ2 1686
type: UnificationXref
id: Q8VHQ2
db: uniprot

uniprot Q1RMJ6 1124
type: UnificationXref
id: Q1RMJ6
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r10
control type: ACTIVATION
controller: cAMP

uniprot P63077 358
type: UnificationXref
id: P63077
db: uniprot

uniprot P68035 1033
type: UnificationXref
id: P68035
db: uniprot

PTHR11937:SF477
type: RelationshipXref
id: PTHR11937:SF477
db: PANTHER Family
relationship type: By Homology

uniprot H9FVW1 1478
type: UnificationXref
id: H9FVW1
db: uniprot

uniprot E1BA29 13
type: UnificationXref
id: E1BA29
db: uniprot

uniprot F7HFU0 681
type: UnificationXref
id: F7HFU0
db: uniprot

PTHR11937:SF473
type: RelationshipXref
id: PTHR11937:SF473
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR10845:SF196
xref: uniprot F7GET1 170
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3YP58 938
organism: Branchiostoma floridae

PTHR11937:SF474
type: RelationshipXref
id: PTHR11937:SF474
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF471
type: RelationshipXref
id: PTHR11937:SF471
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: uniprot P09471 102
organism: Homo sapiens

PTHR11937:SF470
type: RelationshipXref
id: PTHR11937:SF470
db: PANTHER Family
relationship type: By Homology

Calcium/calmodulin-dependent protein kinase type II delta chain
type: ProteinReference
xref: uniprot Q5ZKI0 577
xref: PTHR24347:SF365
organism: Gallus gallus

Myosin-4
type: ProteinReference
xref: uniprot Q29RW1 1334
xref: PTHR45615:SF2
organism: Rattus norvegicus

uniprot Q04206 1107
type: UnificationXref
id: Q04206
db: uniprot

uniprot P79394 756
type: UnificationXref
id: P79394
db: uniprot

PTGS1 isoform 1
type: ProteinReference
xref: PTHR11903:SF6
xref: uniprot K7C9Z9 533
organism: Pan troglodytes

uniprot P68134 1035
type: UnificationXref
id: P68134
db: uniprot

uniprot P15498 1542
type: UnificationXref
id: P15498
db: uniprot

uniprot Q27687 1172
type: UnificationXref
id: Q27687
db: uniprot

PTHR10048:SF34
type: RelationshipXref
id: PTHR10048:SF34
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF33
type: RelationshipXref
id: PTHR10048:SF33
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF35
type: RelationshipXref
id: PTHR10048:SF35
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7HLC7 1373
xref: PTHR10048:SF35
organism: Macaca mulatta

PTHR24355:SF15
type: RelationshipXref
id: PTHR24355:SF15
db: PANTHER Family
relationship type: By Homology

uniprot A2HNG1 894
type: UnificationXref
id: A2HNG1
db: uniprot

uniprot F7F4W9 978
type: UnificationXref
id: F7F4W9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SCX2 1290
xref: PTHR45615:SF1
organism: Monodelphis domestica

Cell Adhesion Cell Shape Change Chemotaxis Degranulation
type: Pathway

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: uniprot O15111 1423
organism: Homo sapiens

uniprot A9V489 918
type: UnificationXref
id: A9V489
db: uniprot

uniprot C3YJC1 187
type: UnificationXref
id: C3YJC1
db: uniprot

uniprot Q5EAP4 40
type: UnificationXref
id: Q5EAP4
db: uniprot

uniprot Q2KIQ8 866
type: UnificationXref
id: Q2KIQ8
db: uniprot

uniprot P18289 445
type: UnificationXref
id: P18289
db: uniprot

uniprot F1N2V3 15
type: UnificationXref
id: F1N2V3
db: uniprot

uniprot P98083 1235
type: UnificationXref
id: P98083
db: uniprot

PTHR10048:SF48
type: RelationshipXref
id: PTHR10048:SF48
db: PANTHER Family
relationship type: By Homology

uniprot F2Z4N0 957
type: UnificationXref
id: F2Z4N0
db: uniprot

uniprot Q9UK08 379
type: UnificationXref
id: Q9UK08
db: uniprot

uniprot Q28FH0 39
type: UnificationXref
id: Q28FH0
db: uniprot

uniprot F7EH19 270
type: UnificationXref
id: F7EH19
db: uniprot

uniprot P50393 797
type: UnificationXref
id: P50393
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 197

PARTICIPANT STOICHIOMETRY r75 1817
type: Stoichiometry
physical entity: Raf-1
stoichiometric coefficient: 1.0

Myosin heavy chain, non-muscle
type: ProteinReference
xref: PTHR45615:SF40
xref: uniprot Q99323 1347
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZMR2 942
organism: Branchiostoma floridae

NFkappaB
type: ProteinReference
xref: P00859
standard name: Nuclear factor kappa-B
comment: ENTITY_REFERENCE_NOTES=Long Name: Nuclear factor kappa-B Synonym: Nuclear factor of kappa light chain gene enhancer in B cells Accession: P00859
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.NF_kappa_B
member entity reference: Nuclear factor kappa B subunit 2
member entity reference: NF-kappa-B inhibitor epsilon
member entity reference: B-cell lymphoma 3 protein homolog
member entity reference: Nuclear factor NF-kappa-B p100 subunit
member entity reference: RELB proto-oncogene, NF-kB subunit
member entity reference: Uncharacterized protein
member entity reference: NF-kappa-B inhibitor alpha
member entity reference: Nuclear factor NF-kappa-B p105 subunit
member entity reference: BCL3, transcription coactivator
member entity reference: Transcription factor p65
member entity reference: Transcription factor RelB
member entity reference: RELA proto-oncogene, NF-kB subunit
member entity reference: NFKB inhibitor epsilon
member entity reference: Proto-oncogene c-Rel
member entity reference: NF-kappaB transcription factor p65 subunit
member entity reference: RELA isoform 1
member entity reference: Nuclear factor kappaB subunit p65

PARTICIPANT STOICHIOMETRY r75 1818
type: Stoichiometry
physical entity: Raf-1
stoichiometric coefficient: 1.0

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot O61861 1591
xref: PTHR12644:SF3
organism: Caenorhabditis elegans

PTHR10048:SF14
type: RelationshipXref
id: PTHR10048:SF14
db: PANTHER Family
relationship type: By Homology

Transcription factor AP-1
type: ProteinReference
xref: uniprot P17325 443
xref: PTHR11462:SF8
organism: Rattus norvegicus

uniprot Q94124 255
type: UnificationXref
id: Q94124
db: uniprot

STAT
type: Complex
component stoichiometry: STAT s119 a174 STOICHIOMETRY ID COMPLEX
component: STAT
feature: ACTIVE 46
cellular location: cytoplasm

uniprot P63217 365
type: UnificationXref
id: P63217
db: uniprot

STAT
type: Complex
component stoichiometry: STAT s121 a176 STOICHIOMETRY ID COMPLEX
component: STAT
feature: ACTIVE 46
cellular location: nucleus

uniprot P63086 285
type: UnificationXref
id: P63086
db: uniprot

Cytokine receptor s95 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cytokine receptor
stoichiometric coefficient: 1.0

cytoplasm
type: CellularLocationVocabulary
xref: GO GO:0005737 3

uniprot Q5E963 1621
type: UnificationXref
id: Q5E963
db: uniprot

PTHR10048:SF29
type: RelationshipXref
id: PTHR10048:SF29
db: PANTHER Family
relationship type: By Homology

uniprot Q28BZ0 241
type: UnificationXref
id: Q28BZ0
db: uniprot

PTHR24355:SF28
type: RelationshipXref
id: PTHR24355:SF28
db: PANTHER Family
relationship type: By Homology

X-C motif chemokine receptor 1
type: ProteinReference
xref: uniprot H2R8C2 689
organism: Pan troglodytes

Protein kinase, cAMP-dependent, catalytic, beta
type: ProteinReference
xref: uniprot Q3ZB92 1175
xref: PTHR24353:SF116
organism: Danio rerio

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A0A1D5R8E9 1435
xref: PTHR10336:SF173
organism: Macaca mulatta

Myosin-IIIb
type: ProteinReference
xref: uniprot Q8WXR4 1345
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r42 1825
type: Stoichiometry
physical entity: PDK1
stoichiometric coefficient: 1.0

PTHR24355:SF22
type: RelationshipXref
id: PTHR24355:SF22
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r42 1826
type: Stoichiometry
physical entity: PDK1
stoichiometric coefficient: 1.0

uniprot G3V7M2 644
type: UnificationXref
id: G3V7M2
db: uniprot

Cytokine receptor
type: Protein
entity reference: Cytokine receptor
feature: ACTIVE 46

PARTICIPANT STOICHIOMETRY r22 1907
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF1
xref: uniprot Q3T035 1618
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r29 1871
type: Stoichiometry
physical entity: AKT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r29 1870
type: Stoichiometry
physical entity: AKT
stoichiometric coefficient: 1.0

Myosin-14
type: ProteinReference
xref: PTHR45615:SF31
xref: uniprot Q7Z406 1341
organism: Homo sapiens

uniprot A3KMS9 1142
type: UnificationXref
id: A3KMS9
db: uniprot

uniprot A4IGZ2 310
type: UnificationXref
id: A4IGZ2
db: uniprot

C-C motif chemokine receptor 8
type: ProteinReference
xref: PTHR10489:SF627
xref: uniprot D4ADE0 667
organism: Rattus norvegicus

Interferon gamma
type: ProteinReference
xref: uniprot P63310 1664
xref: PTHR11419:SF0
organism: Macaca mulatta

uniprot H2RDU2 692
type: UnificationXref
id: H2RDU2
db: uniprot

PKC
type: ProteinReference
xref: P00861
standard name: Protein kinase C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.PKC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein kinase C Synonym: PKC Accession: P00861
member entity reference: Protein kinase C
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C beta type
member entity reference: Protein kinase C zeta type

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6RCU6 60
organism: Macaca mulatta

uniprot O54910 1102
type: UnificationXref
id: O54910
db: uniprot

NFkappaB
type: Protein
entity reference: NFkappaB
feature: ACTIVE 46
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F6X927 1419
organism: Macaca mulatta

Arachidonate 12-lipoxygenase, 12S-type
type: ProteinReference
xref: PTHR11771:SF4
xref: uniprot F1LQ70 127
organism: Rattus norvegicus

CHKR s207 sa159 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHKR
stoichiometric coefficient: 1.0

Prostaglandin G/H synthase 1
type: ProteinReference
xref: PTHR11903:SF6
xref: uniprot Q63921 539
organism: Rattus norvegicus

ROCK
type: Protein
entity reference: ROCK
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot H2R3A6 343
type: UnificationXref
id: H2R3A6
db: uniprot

uniprot C3YKS6 937
type: UnificationXref
id: C3YKS6
db: uniprot

Ras-related protein rac-2
type: ProteinReference
xref: uniprot Q94124 255
organism: Caenorhabditis elegans

Gbetagamma s12 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbetagamma
stoichiometric coefficient: 1.0

…
type: Stoichiometry
physical entity: Cytokine receptor
stoichiometric coefficient: 2.0

Yarrowia lipolytica
type: BioSource
xref: ncbitaxon 284591 1087

Ifngr2 protein
type: ProteinReference
xref: uniprot Q63953 1245
xref: PTHR20859:SF46
organism: Mus musculus

uniprot A8XRA5 1445
type: UnificationXref
id: A8XRA5
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot Q02956 123
organism: Mus musculus

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1P354 1453
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot A0A1D5Q071 449
organism: Macaca mulatta

C-C motif chemokine 20
type: ProteinReference
xref: PTHR12015:SF108
xref: uniprot O89093 826
organism: Mus musculus

NF-kappa-B inhibitor epsilon
type: ProteinReference
xref: uniprot O54910 1102
organism: Mus musculus

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot Q3ZC07 1049
organism: Bos taurus

Ras
type: Protein
entity reference: Ras
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_r8
control type: INHIBITION
controller: Complex (Galphai/GTP)

Guanine nucleotide-binding protein subunit alpha-15
type: ProteinReference
xref: PTHR10218:SF217
xref: uniprot O88302 24
organism: Rattus norvegicus

uniprot O09047 699
type: UnificationXref
id: O09047
db: uniprot

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_r9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 1784
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 1785
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot A8WWE8 1554
xref: PTHR12644:SF3
organism: Caenorhabditis briggsae

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot F6VHF7 489
xref: PTHR13715:SF52
organism: Xenopus tropicalis

uniprot F6SDC9 964
type: UnificationXref
id: F6SDC9
db: uniprot

PTHR10250:SF2
type: RelationshipXref
id: PTHR10250:SF2
db: PANTHER Family
relationship type: By Homology

uniprot F1QVX3 1284
type: UnificationXref
id: F1QVX3
db: uniprot

PTHR10250:SF4
type: RelationshipXref
id: PTHR10250:SF4
db: PANTHER Family
relationship type: By Homology

uniprot D4A3T0 595
type: UnificationXref
id: D4A3T0
db: uniprot

Peripheral plasma membrane protein CASK
type: ProteinReference
xref: PTHR23122:SF40
xref: uniprot O70589 568
organism: Mus musculus

uniprot P40518 1602
type: UnificationXref
id: P40518
db: uniprot

Suppressor of cytokine signaling 5
type: ProteinReference
xref: uniprot O54928 1683
xref: PTHR10155:SF15
organism: Mus musculus

Arachidonate 15-lipoxygenase
type: ProteinReference
xref: uniprot P27479 136
xref: PTHR11771:SF33
organism: Bos taurus

uniprot Q60823 72
type: UnificationXref
id: Q60823
db: uniprot

PARTICIPANT STOICHIOMETRY r22 1908
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 1909
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

ncbitaxon 10116 25
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot A0A2I3S7U4 659
type: UnificationXref
id: A0A2I3S7U4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DIB7 974
xref: PTHR11937:SF414
organism: Monodelphis domestica

uniprot Q9QW07 1529
type: UnificationXref
id: Q9QW07
db: uniprot

uniprot A0A1D5QLW3 604
type: UnificationXref
id: A0A1D5QLW3
db: uniprot

uniprot P42337 1382
type: UnificationXref
id: P42337
db: uniprot

uniprot Q02566 1328
type: UnificationXref
id: Q02566
db: uniprot

C-C motif chemokine 20
type: ProteinReference
xref: PTHR12015:SF108
xref: uniprot P97884 863
organism: Rattus norvegicus

uniprot P35749 1327
type: UnificationXref
id: P35749
db: uniprot

Serine/threonine-protein kinase pak-1
type: ProteinReference
xref: uniprot Q17850 416
organism: Caenorhabditis elegans

uniprot F0ZQR3 196
type: UnificationXref
id: F0ZQR3
db: uniprot

SrcPTK
type: Protein
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

AC
type: Protein
entity reference: AC
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: uniprot Q922R0 1185
xref: PTHR24353:SF37
organism: Mus musculus

actin, muscle
type: ProteinReference
xref: uniprot F6SDC9 964
organism: Ciona intestinalis

uniprot P30678 34
type: UnificationXref
id: P30678
db: uniprot

uniprot Q9Y4X3 881
type: UnificationXref
id: Q9Y4X3
db: uniprot

PTHR22829:SF6
type: RelationshipXref
id: PTHR22829:SF6
db: PANTHER Family
relationship type: By Homology

uniprot P08754 101
type: UnificationXref
id: P08754
db: uniprot

uniprot A0A3Q1LPV4 555
type: UnificationXref
id: A0A3Q1LPV4
db: uniprot

uniprot Q9XSD7 782
type: UnificationXref
id: Q9XSD7
db: uniprot

uniprot Q71MR7 768
type: UnificationXref
id: Q71MR7
db: uniprot

Myosin, heavy polypeptide 2, fast muscle-specific
type: ProteinReference
xref: PTHR45615:SF44
xref: uniprot Q6IQX1 1339
organism: Danio rerio

NFKB inhibitor epsilon
type: ProteinReference
xref: uniprot Q6P780 1111
organism: Rattus norvegicus

cAMP-dependent protein kinase, catalytic subunit-like
type: ProteinReference
xref: uniprot Q7JP68 1179
xref: PTHR24353:SF37
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r60 1867
type: Stoichiometry
physical entity: Complex (Cytokine receptor/JAK/ JAK/STAT/ INFgamma)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r60 1865
type: Stoichiometry
physical entity: Complex (Cytokine receptor/JAK/ JAK/INFgamma)
stoichiometric coefficient: 1.0

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
type: ProteinReference
xref: uniprot Q69ZK0 1546
xref: PTHR22829:SF6
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r60 1866
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

GPRK
type: Protein
entity reference: GPRK
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F6U6I0 675
xref: PTHR10489:SF637
organism: Macaca mulatta

uniprot Q14643 502
type: UnificationXref
id: Q14643
db: uniprot

uniprot P39745 283
type: UnificationXref
id: P39745
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RI29 1092
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF196
xref: uniprot Q9FXT7 302
organism: Chlamydomonas reinhardtii

C-C motif chemokine 26
type: ProteinReference
xref: uniprot Q9Y258 880
xref: PTHR12015:SF73
organism: Homo sapiens

uniprot F1MSU2 612
type: UnificationXref
id: F1MSU2
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__JAK-RIGHT__JAK-_r54
control type: INHIBITION
controller: SOCS

Complex (Cytokine receptor/JAK/ JAK/IL2)
type: Complex
component stoichiometry: JAK s90 sa39 STOICHIOMETRY ID COMPLEX
component stoichiometry: IL2 s92 sa41 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cytokine receptor s81 sa38 STOICHIOMETRY ID COMPLEX
component: IL2
component: JAK
component: Cytokine receptor
feature: COMPLEX BINDING FEATURE s192 a275 1740
feature: COMPLEX BINDING FEATURE s192 a275 1738
feature: COMPLEX BINDING FEATURE s192 a275 1736
cellular location: cytoplasm

C-C motif chemokine 21b
type: ProteinReference
xref: uniprot P86792 861
organism: Mus musculus

uniprot Q6P780 1111
type: UnificationXref
id: Q6P780
db: uniprot

uniprot P54674 1386
type: UnificationXref
id: P54674
db: uniprot

Actin-related protein 2/3 complex subunit 1A
type: ProteinReference
xref: uniprot Q1JP79 1614
xref: PTHR10709:SF11
organism: Bos taurus

uniprot F6Y1Q0 808
type: UnificationXref
id: F6Y1Q0
db: uniprot

JAK s70 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JAK
stoichiometric coefficient: 2.0

uniprot P53478 1008
type: UnificationXref
id: P53478
db: uniprot

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: uniprot Q92352 1629
xref: PTHR22629:SF0
organism: Schizosaccharomyces pombe

DISSOCIATION_LEFT__Complex__Cytokine_receptor_IL2__STAT_JAK__JAK_-RIGHT__Complex__Cytokine_receptor_JAK__JAK_IL2_-_STAT-_r88
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r88 1893
participant stoichiometry: PARTICIPANT STOICHIOMETRY r88 1892
participant stoichiometry: PARTICIPANT STOICHIOMETRY r88 1891
left: Complex (Cytokine receptor/IL2/ STAT/JAK/ JAK)
interaction type: DISSOCIATION
right: STAT
right: Complex (Cytokine receptor/JAK/ JAK/IL2)

Calcium/calmodulin-dependent protein kinase type II subunit beta
type: ProteinReference
xref: uniprot Q3MHJ9 576
xref: PTHR24347:SF403
organism: Bos taurus

uniprot Q8BTW9 423
type: UnificationXref
id: Q8BTW9
db: uniprot

uniprot P28482 282
type: UnificationXref
id: P28482
db: uniprot

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 4

Cdc42
type: Protein
entity reference: Cdc42
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 81824 919
type: UnificationXref
id: 81824
db: ncbitaxon

Guanine nucleotide-binding protein G(O) subunit alpha isoform a
type: ProteinReference
xref: uniprot F7GQC5 94
organism: Macaca mulatta

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q9Y243 80
xref: PTHR24356:SF190
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re70 1859
type: Stoichiometry
physical entity: Complex (CHKR/CHK)
stoichiometric coefficient: 1.0

uniprot H2QSU0 494
type: UnificationXref
id: H2QSU0
db: uniprot

PARTICIPANT STOICHIOMETRY re70 1858
type: Stoichiometry
physical entity: Complex (CHKR/CHK)
stoichiometric coefficient: 1.0

AC
type: Protein
entity reference: AC
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P43425 352
xref: PTHR13809:SF8
organism: Rattus norvegicus

Protein kinase, X-linked
type: ProteinReference
xref: uniprot Q5BK52 1176
xref: PTHR24353:SF37
organism: Rattus norvegicus

COL14A1 isoform 4
type: ProteinReference
xref: uniprot A0A2I3S4E5 1190
xref: PTHR24020:SF15
organism: Pan troglodytes

uniprot P62739 1021
type: UnificationXref
id: P62739
db: uniprot

uniprot H2R0Z4 687
type: UnificationXref
id: H2R0Z4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VQA9 677
xref: PTHR10489:SF611
organism: Macaca mulatta

uniprot Q60847 1219
type: UnificationXref
id: Q60847
db: uniprot

uniprot H2QMN4 96
type: UnificationXref
id: H2QMN4
db: uniprot

uniprot P19073 214
type: UnificationXref
id: P19073
db: uniprot

uniprot O45815 988
type: UnificationXref
id: O45815
db: uniprot

uniprot P34146 219
type: UnificationXref
id: P34146
db: uniprot

PTHR22629:SF0
type: RelationshipXref
id: PTHR22629:SF0
db: PANTHER Family
relationship type: By Homology

uniprot E2RGI5 314
type: UnificationXref
id: E2RGI5
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot Q02158 1500
organism: Dictyostelium discoideum

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot Q02156 1139
xref: PTHR24356:SF159
organism: Homo sapiens

Ras-like protein 2
type: ProteinReference
xref: uniprot P04388 1405
organism: Drosophila melanogaster

uniprot F7DUD6 1368
type: UnificationXref
id: F7DUD6
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7FDA0 1370
organism: Monodelphis domestica

uniprot F7EQH3 1575
type: UnificationXref
id: F7EQH3
db: uniprot

uniprot C3YC50 936
type: UnificationXref
id: C3YC50
db: uniprot

uniprot O54814 702
type: UnificationXref
id: O54814
db: uniprot

P00836
type: UnificationXref
id: P00836
db: PANTHER Pathway Component

PTHR13809:SF19
type: RelationshipXref
id: PTHR13809:SF19
db: PANTHER Family
relationship type: By Homology

P00835
type: UnificationXref
id: P00835
db: PANTHER Pathway Component

P00834
type: UnificationXref
id: P00834
db: PANTHER Pathway Component

P00833
type: UnificationXref
id: P00833
db: PANTHER Pathway Component

uniprot Q1K5B4 1615
type: UnificationXref
id: Q1K5B4
db: uniprot

P00832
type: UnificationXref
id: P00832
db: PANTHER Pathway Component

P00831
type: UnificationXref
id: P00831
db: PANTHER Pathway Component

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot P70227 499
xref: PTHR13715:SF51
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VQP7 490
xref: PTHR13715:SF52
organism: Monodelphis domestica

uniprot B5DF62 385
type: UnificationXref
id: B5DF62
db: uniprot

P00830
type: UnificationXref
id: P00830
db: PANTHER Pathway Component

PTHR13809:SF11
type: RelationshipXref
id: PTHR13809:SF11
db: PANTHER Family
relationship type: By Homology

uniprot O08638 1312
type: UnificationXref
id: O08638
db: uniprot

P00839
type: UnificationXref
id: P00839
db: PANTHER Pathway Component

uniprot A9TBG2 912
type: UnificationXref
id: A9TBG2
db: uniprot

P00838
type: UnificationXref
id: P00838
db: PANTHER Pathway Component

uniprot O77627 437
type: UnificationXref
id: O77627
db: uniprot

P00837
type: UnificationXref
id: P00837
db: PANTHER Pathway Component

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot E1B8P9 265
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r6 1793
type: Stoichiometry
physical entity: Complex (Galphai/GTP)
stoichiometric coefficient: 1.0

ncbitaxon 10090 29
type: UnificationXref
id: 10090
db: ncbitaxon

Calcium/calmodulin dependent protein kinase II gamma
type: ProteinReference
xref: PTHR24347:SF398
xref: uniprot A0A2I3TUE7 554
organism: Pan troglodytes

uniprot F6WFN3 1292
type: UnificationXref
id: F6WFN3
db: uniprot

CAMK2A isoform 3
type: ProteinReference
xref: PTHR24347:SF384
xref: uniprot A0A2I3STB7 552
organism: Pan troglodytes

uniprot F6THW2 16
type: UnificationXref
id: F6THW2
db: uniprot

uniprot P63096 107
type: UnificationXref
id: P63096
db: uniprot

PARTICIPANT STOICHIOMETRY r6 1792
type: Stoichiometry
physical entity: Complex (Galphai/q/ GTP)
stoichiometric coefficient: 1.0

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 322

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot P68033 1031
organism: Mus musculus

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot P68032 1030
organism: Homo sapiens

Myosin heavy chain 7B
type: ProteinReference
xref: PTHR45615:SF29
xref: uniprot A0A2I3S3U5 1254
organism: Pan troglodytes

uniprot Q91UZ1 1521
type: UnificationXref
id: Q91UZ1
db: uniprot

PTHR13809:SF25
type: RelationshipXref
id: PTHR13809:SF25
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR24347:SF394
xref: uniprot F7G5G3 1647
organism: Macaca mulatta

PTHR13809:SF21
type: RelationshipXref
id: PTHR13809:SF21
db: PANTHER Family
relationship type: By Homology

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot P40376 1168
organism: Schizosaccharomyces pombe

P00827
type: UnificationXref
id: P00827
db: PANTHER Pathway Component

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot P68035 1033
organism: Rattus norvegicus

P00826
type: UnificationXref
id: P00826
db: PANTHER Pathway Component

Eotaxin
type: ProteinReference
xref: PTHR12015:SF168
xref: uniprot P48298 846
organism: Mus musculus

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot P68034 1032
organism: Gallus gallus

P00829
type: UnificationXref
id: P00829
db: PANTHER Pathway Component

PTHR24055:SF401
type: RelationshipXref
id: PTHR24055:SF401
db: PANTHER Family
relationship type: By Homology

uniprot F7G117 1300
type: UnificationXref
id: F7G117
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot O89040 1483
organism: Rattus norvegicus

P00828
type: UnificationXref
id: P00828
db: PANTHER Pathway Component

uniprot H2QXW1 1582
type: UnificationXref
id: H2QXW1
db: uniprot

MAPK
type: ProteinReference
xref: P00835
standard name: Mitogen activated protein kinase
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.MAPK
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen activated protein kinase Synonym: MAP kinase Accession: P00835
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Mitogen-activated protein kinase 4
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Mitogen-activated protein kinase 5
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase (Fragment)
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase 2
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase KSS1
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase 7
member entity reference: Mitogen-activated protein kinase 6
member entity reference: Extracellular signal-regulated kinase 1
member entity reference: Mitogen-activated protein kinase mpk-1
member entity reference: Mitogen-activated protein kinase 10
member entity reference: Mitogen-activated protein kinase spk1
member entity reference: Mitogen-activated protein kinase FUS3
member entity reference: Mitogen-activated protein kinase 14

PTHR24055:SF417
type: RelationshipXref
id: PTHR24055:SF417
db: PANTHER Family
relationship type: By Homology

MYO3A isoform 1
type: ProteinReference
xref: uniprot H2Q1R1 1305
xref: PTHR46256:SF4
organism: Pan troglodytes

Suppressor of cytokine signaling 7
type: ProteinReference
xref: uniprot E1BIS1 1670
xref: PTHR10155:SF5
organism: Bos taurus

uniprot Q61011 371
type: UnificationXref
id: Q61011
db: uniprot

P00860
type: UnificationXref
id: P00860
db: PANTHER Pathway Component

P00861
type: UnificationXref
id: P00861
db: PANTHER Pathway Component

P00854
type: UnificationXref
id: P00854
db: PANTHER Pathway Component

uniprot Q8I4X0 1078
type: UnificationXref
id: Q8I4X0
db: uniprot

P00853
type: UnificationXref
id: P00853
db: PANTHER Pathway Component

SOCS6 isoform 1
type: ProteinReference
xref: PTHR10155:SF17
xref: uniprot H2QEP3 1677
organism: Pan troglodytes

P00852
type: UnificationXref
id: P00852
db: PANTHER Pathway Component

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__CaMK-RIGHT__CaMK-_r26
control type: ACTIVATION
controller: Ca2+

P00851
type: UnificationXref
id: P00851
db: PANTHER Pathway Component

uniprot F6SD46 1460
type: UnificationXref
id: F6SD46
db: uniprot

P00858
type: UnificationXref
id: P00858
db: PANTHER Pathway Component

P00857
type: UnificationXref
id: P00857
db: PANTHER Pathway Component

P00856
type: UnificationXref
id: P00856
db: PANTHER Pathway Component

P00855
type: UnificationXref
id: P00855
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A818 492
xref: PTHR13715:SF53
organism: Macaca mulatta

Myosin-7
type: ProteinReference
xref: uniprot Q9BE39 1348
xref: PTHR45615:SF1
organism: Bos taurus

uniprot F1MYS4 803
type: UnificationXref
id: F1MYS4
db: uniprot

P00859
type: UnificationXref
id: P00859
db: PANTHER Pathway Component

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P60952 226
xref: PTHR24072:SF136
organism: Canis lupus familiaris

uniprot Q9SJW6 1637
type: UnificationXref
id: Q9SJW6
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot F6WN02 1570
xref: PTHR12644:SF1
organism: Ornithorhynchus anatinus

PTHR10082:SF15
type: RelationshipXref
id: PTHR10082:SF15
db: PANTHER Family
relationship type: By Homology

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P60953 227
xref: PTHR24072:SF136
organism: Homo sapiens

SrcPTK
type: Protein
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Ras-related protein ced-10
type: ProteinReference
xref: uniprot Q03206 235
organism: Caenorhabditis elegans

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot Q7PUF2 1625
xref: PTHR12391:SF0
organism: Anopheles gambiae

PTHR10082:SF28
type: RelationshipXref
id: PTHR10082:SF28
db: PANTHER Family
relationship type: By Homology

Cytokine receptor
type: Protein
entity reference: Cytokine receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s81 sa38 1737
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P10398 524
type: UnificationXref
id: P10398
db: uniprot

uniprot D3ZS72 1535
type: UnificationXref
id: D3ZS72
db: uniprot

STATE_TRANSITION_LEFT__PIP2-RIGHT__DAG-_IP3-_r22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 1908
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 1909
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 1907
left: PIP2
interaction type: STATE_TRANSITION
right: IP3
right: DAG

P00850
type: UnificationXref
id: P00850
db: PANTHER Pathway Component

P00841
type: UnificationXref
id: P00841
db: PANTHER Pathway Component

Myosin-1
type: ProteinReference
xref: PTHR45615:SF3
xref: uniprot Q9BE40 1349
organism: Bos taurus

P00840
type: UnificationXref
id: P00840
db: PANTHER Pathway Component

P00843
type: UnificationXref
id: P00843
db: PANTHER Pathway Component

PTHR13809:SF48
type: RelationshipXref
id: PTHR13809:SF48
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r30 1864
type: Stoichiometry
physical entity: GEF
stoichiometric coefficient: 1.0

P00842
type: UnificationXref
id: P00842
db: PANTHER Pathway Component

P00845
type: UnificationXref
id: P00845
db: PANTHER Pathway Component

P00847
type: UnificationXref
id: P00847
db: PANTHER Pathway Component

P00846
type: UnificationXref
id: P00846
db: PANTHER Pathway Component

P00849
type: UnificationXref
id: P00849
db: PANTHER Pathway Component

P00848
type: UnificationXref
id: P00848
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r30 1863
type: Stoichiometry
physical entity: GEF
stoichiometric coefficient: 1.0

eco ECO:0000250 7
type: UnificationXref
id: ECO:0000250
db: eco

uniprot E2RQM0 1448
type: UnificationXref
id: E2RQM0
db: uniprot

uniprot Q03343 477
type: UnificationXref
id: Q03343
db: uniprot

uniprot F6U298 1229
type: UnificationXref
id: F6U298
db: uniprot

STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r32
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 1852
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 1853
left: Rac
interaction type: STATE_TRANSITION
right: Rac

uniprot H2RI77 1154
type: UnificationXref
id: H2RI77
db: uniprot

Galphai q s21 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Galphai/q
stoichiometric coefficient: 1.0

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot H2QV01 1581
xref: PTHR10709:SF10
organism: Pan troglodytes

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot H2QV00 1580
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot F7ECA6 19
organism: Monodelphis domestica

PTHR10082:SF36
type: RelationshipXref
id: PTHR10082:SF36
db: PANTHER Family
relationship type: By Homology

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2R481 391
organism: Canis lupus familiaris

uniprot P34997 721
type: UnificationXref
id: P34997
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r23
controller: DAG

uniprot Q2HJF7 575
type: UnificationXref
id: Q2HJF7
db: uniprot

uniprot Q9VIM5 1638
type: UnificationXref
id: Q9VIM5
db: uniprot

uniprot F6TUR3 965
type: UnificationXref
id: F6TUR3
db: uniprot

uniprot H9Z8H4 1239
type: UnificationXref
id: H9Z8H4
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__CHKR_Galphai__q_GDP__Gbetagamma_-_CHK-RIGHT__Complex__CHKR_CHK__Galphai_q__GDP_Gbetagamma_-_r2
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 1812
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 1811
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 1810
left: CHK
left: Complex (CHKR/Galphai/ q/GDP/ Gbetagamma)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (CHKR/CHK/ Galphai/q/ GDP/Gbetagamma)

C-C motif chemokine 2
type: ProteinReference
xref: uniprot P61275 853
organism: Macaca mulatta

uniprot P10986 999
type: UnificationXref
id: P10986
db: uniprot

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: PTHR24353:SF133
xref: uniprot P51817 1169
organism: Homo sapiens

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: PTHR12644:SF2
xref: uniprot F6WN64 1571
organism: Monodelphis domestica

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot A0A2I3TNH3 587
xref: PTHR12305:SF81
organism: Pan troglodytes

Guanine nucleotide-binding protein (G protein), q polypeptide
type: ProteinReference
xref: uniprot Q28FH0 39
organism: Xenopus tropicalis

uniprot P02565 1315
type: UnificationXref
id: P02565
db: uniprot

uniprot H2QF58 1540
type: UnificationXref
id: H2QF58
db: uniprot

uniprot P18499 1002
type: UnificationXref
id: P18499
db: uniprot

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: PTHR12058:SF0
xref: uniprot Q3MHR7 1616
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot Q9JHG7 1391
xref: PTHR10048:SF34
organism: Mus musculus

uniprot Q8CH33 770
type: UnificationXref
id: Q8CH33
db: uniprot

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot A0A2I3T5A0 1549
organism: Pan troglodytes

STAT s119 a174 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: uniprot P22612 1164
xref: PTHR24353:SF137
organism: Homo sapiens

…
type: Stoichiometry
physical entity: Cytokine receptor
stoichiometric coefficient: 2.0

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot F7CQJ3 1574
organism: Xenopus tropicalis

uniprot Q9TTS6 879
type: UnificationXref
id: Q9TTS6
db: uniprot

VAV1 isoform 2
type: ProteinReference
xref: PTHR45818:SF2
xref: uniprot H2QF58 1540
organism: Pan troglodytes

uniprot A0A2I3SYV7 541
type: UnificationXref
id: A0A2I3SYV7
db: uniprot

uniprot O70589 568
type: UnificationXref
id: O70589
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9DAS9 377
xref: PTHR13809:SF9
organism: Mus musculus

uniprot G2HHW9 1101
type: UnificationXref
id: G2HHW9
db: uniprot

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot O88351 1424
organism: Mus musculus

uniprot F7GI54 336
type: UnificationXref
id: F7GI54
db: uniprot

Probable actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot Q9XWV3 1643
xref: PTHR12391:SF0
organism: Caenorhabditis elegans

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot Q7PUB7 1624
organism: Anopheles gambiae

uniprot P50153 355
type: UnificationXref
id: P50153
db: uniprot

ncbitaxon 284812 234
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot E2RG11 669
type: UnificationXref
id: E2RG11
db: uniprot

CHKR s6 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHKR
stoichiometric coefficient: 1.0

uniprot Q75D00 1071
type: UnificationXref
id: Q75D00
db: uniprot

MEK s161 a235 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05771 1136
xref: PTHR24356:SF158
organism: Homo sapiens

GO GO:0005783 4
type: UnificationXref
id: GO:0005783
db: GO

uniprot Q5SX40 1336
type: UnificationXref
id: Q5SX40
db: uniprot

uniprot Q076A4 1329
type: UnificationXref
id: Q076A4
db: uniprot

uniprot P01580 1659
type: UnificationXref
id: P01580
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot F7CXD0 331
organism: Monodelphis domestica

uniprot F7H582 470
type: UnificationXref
id: F7H582
db: uniprot

Peripheral plasma membrane protein CASK
type: ProteinReference
xref: PTHR23122:SF40
xref: uniprot Q62915 578
organism: Rattus norvegicus

Protein kinase cAMP-activated catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H2QFK0 1151
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR24347:SF398
xref: uniprot F7FD93 563
organism: Macaca mulatta

uniprot O54689 701
type: UnificationXref
id: O54689
db: uniprot

Cytokine receptor s81 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cytokine receptor
stoichiometric coefficient: 1.0

Collagen alpha-1(XX) chain
type: ProteinReference
xref: PTHR24020:SF39
xref: uniprot Q9P218 1225
organism: Homo sapiens

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 74

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 316
xref: PTHR13809:SF19
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
type: ProteinReference
xref: uniprot Q9P212 1528
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7F3S0 1369
organism: Macaca mulatta

uniprot P49147 795
type: UnificationXref
id: P49147
db: uniprot

uniprot E1BA17 1192
type: UnificationXref
id: E1BA17
db: uniprot

PTHR23122:SF40
type: RelationshipXref
id: PTHR23122:SF40
db: PANTHER Family
relationship type: By Homology

uniprot H2QC17 131
type: UnificationXref
id: H2QC17
db: uniprot

STATE_TRANSITION_LEFT__JAK-RIGHT__JAK-_r54
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 1906
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 1905
left: JAK
interaction type: STATE_TRANSITION
right: JAK

Interleukin-15
type: ProteinReference
xref: uniprot P48346 1411
organism: Mus musculus

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: uniprot P33204 1600
xref: PTHR22629:SF0
organism: Saccharomyces cerevisiae

Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
type: ProteinReference
xref: PTHR22829:SF6
xref: uniprot F1N1Q7 1537
organism: Bos taurus

uniprot P53492 1009
type: UnificationXref
id: P53492
db: uniprot

uniprot Q148J6 1612
type: UnificationXref
id: Q148J6
db: uniprot

GTP s20 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot F7BB02 329
organism: Macaca mulatta

ncbitaxon 9031 42
type: UnificationXref
id: 9031
db: ncbitaxon

Fractalkine
type: ProteinReference
xref: uniprot O55145 824
organism: Rattus norvegicus

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot Q13153 414
organism: Homo sapiens

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot Q1KQ07 162
xref: PTHR11801:SF48
organism: Rattus norvegicus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot H2PXY8 1374
xref: PTHR10048:SF35
organism: Pan troglodytes

uniprot F7GY91 205
type: UnificationXref
id: F7GY91
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HLU2 682
xref: PTHR10489:SF618
organism: Macaca mulatta

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF11
xref: uniprot E1B9K3 465
organism: Bos taurus

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__ROCK-RIGHT__ROCK-_r35
control type: INHIBITION
controller: PAK

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

uniprot F6QJR2 673
type: UnificationXref
id: F6QJR2
db: uniprot

PARTICIPANT STOICHIOMETRY r45 1814
type: Stoichiometry
physical entity: IKK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 1813
type: Stoichiometry
physical entity: IKK
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A7F7Z6 180
organism: Sclerotinia sclerotiorum

uniprot P05556 648
type: UnificationXref
id: P05556
db: uniprot

Arachidonate 15-lipoxygenase
type: ProteinReference
xref: uniprot P16050 132
xref: PTHR11771:SF33
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A7I3 971
xref: PTHR11937:SF477
organism: Monodelphis domestica

uniprot Q9JM76 1635
type: UnificationXref
id: Q9JM76
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot P16054 1137
xref: PTHR24356:SF159
organism: Mus musculus

uniprot F7GWI2 406
type: UnificationXref
id: F7GWI2
db: uniprot

uniprot Q56W08 1509
type: UnificationXref
id: Q56W08
db: uniprot

uniprot Q5I1Z0 868
type: UnificationXref
id: Q5I1Z0
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot O60262 347
organism: Homo sapiens

ncbitaxon 367110 112
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot Q96292 1082
type: UnificationXref
id: Q96292
db: uniprot

uniprot P48554 224
type: UnificationXref
id: P48554
db: uniprot

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
type: ProteinReference
xref: uniprot Q3ZCA7 115
organism: Bos taurus

IL2
type: Protein
entity reference: IL2
feature: COMPLEX PARTICIPANT BINDING FEATURE s100 sa45 1777
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR24055:SF378
type: RelationshipXref
id: PTHR24055:SF378
db: PANTHER Family
relationship type: By Homology

C-C chemokine receptor type 4
type: ProteinReference
xref: uniprot Q8MJW8 771
xref: PTHR10489:SF608
organism: Canis lupus familiaris

uniprot F6QDY0 787
type: UnificationXref
id: F6QDY0
db: uniprot

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot Q90694 254
xref: PTHR24072:SF136
organism: Gallus gallus

uniprot P46094 728
type: UnificationXref
id: P46094
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ES59 1118
xref: PTHR24072:SF100
organism: Monodelphis domestica

JAK
type: Protein
entity reference: JAK
feature: ACTIVE 46
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa23 1771
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P26011 654
type: UnificationXref
id: P26011
db: uniprot

uniprot F6WN02 1570
type: UnificationXref
id: F6WN02
db: uniprot

uniprot Q9BE39 1348
type: UnificationXref
id: Q9BE39
db: uniprot

DISSOCIATION_LEFT__Complex__Cytokine_receptor_JAK__JAK_STAT__INFgamma_-RIGHT__Complex__Cytokine_receptor_JAK__JAK_INFgamma_-_STAT-_r62
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 1861
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 1862
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 1860
left: Complex (Cytokine receptor/JAK/ JAK/STAT/ INFgamma)
interaction type: DISSOCIATION
right: STAT
right: Complex (Cytokine receptor/JAK/ JAK/INFgamma)

uniprot A0A3Q1MMD9 1441
type: UnificationXref
id: A0A3Q1MMD9
db: uniprot

Regulator of G-protein signaling 17
type: ProteinReference
xref: PTHR10845:SF196
xref: uniprot Q9QZB0 179
organism: Mus musculus

P00864
type: UnificationXref
id: P00864
db: PANTHER Pathway Component

P00865
type: UnificationXref
id: P00865
db: PANTHER Pathway Component

P00862
type: UnificationXref
id: P00862
db: PANTHER Pathway Component

P00863
type: UnificationXref
id: P00863
db: PANTHER Pathway Component

P00868
type: UnificationXref
id: P00868
db: PANTHER Pathway Component

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot O55173 149
organism: Rattus norvegicus

P00869
type: UnificationXref
id: P00869
db: PANTHER Pathway Component

P00866
type: UnificationXref
id: P00866
db: PANTHER Pathway Component

P00867
type: UnificationXref
id: P00867
db: PANTHER Pathway Component

PTHR23220:SF130
type: RelationshipXref
id: PTHR23220:SF130
db: PANTHER Family
relationship type: By Homology

uniprot Q99MK8 463
type: UnificationXref
id: Q99MK8
db: uniprot

uniprot F7CU42 403
type: UnificationXref
id: F7CU42
db: uniprot

C-C motif chemokine
type: ProteinReference
xref: uniprot F1MYS4 803
organism: Bos taurus

P00872
type: UnificationXref
id: P00872
db: PANTHER Pathway Component

P00871
type: UnificationXref
id: P00871
db: PANTHER Pathway Component

P00870
type: UnificationXref
id: P00870
db: PANTHER Pathway Component

uniprot A0A1D5QVF6 551
type: UnificationXref
id: A0A1D5QVF6
db: uniprot

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa17 1751
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

C-C motif chemokine receptor 10
type: ProteinReference
xref: PTHR10489:SF773
xref: uniprot E2RG11 669
organism: Canis lupus familiaris

IKK
type: Protein
entity reference: IKK
feature: IKK s199 a131 rs1
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

DISSOCIATION
type: InteractionVocabulary

PTHR13809:SF52
type: RelationshipXref
id: PTHR13809:SF52
db: PANTHER Family
relationship type: By Homology

Galphaq
type: ProteinReference
xref: P00826
standard name: Gq-protein, alpha subunit
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.G_alpha__sub_q
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)
member entity reference: Guanine nucleotide-binding protein subunit alpha-11
member entity reference: G protein subunit alpha q
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 14
member entity reference: Guanine nucleotide-binding protein subunit alpha-14
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein (G protein), q polypeptide
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)
member entity reference: G protein subunit alpha 14
member entity reference: Guanine nucleotide-binding protein G(q) subunit alpha
member entity reference: Guanine nucleotide-binding protein subunit alpha-15

PTHR13809:SF51
type: RelationshipXref
id: PTHR13809:SF51
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F5HEA9 268
xref: PTHR24055:SF158
organism: Phaeosphaeria nodorum

Integrin s23 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Integrin
stoichiometric coefficient: 1.0

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot Q9VMH2 1639
organism: Drosophila melanogaster

P00873
type: UnificationXref
id: P00873
db: PANTHER Pathway Component

P00874
type: UnificationXref
id: P00874
db: PANTHER Pathway Component

P00875
type: UnificationXref
id: P00875
db: PANTHER Pathway Component

uniprot Q5RKN6 586
type: UnificationXref
id: Q5RKN6
db: uniprot

P00876
type: UnificationXref
id: P00876
db: PANTHER Pathway Component

P00877
type: UnificationXref
id: P00877
db: PANTHER Pathway Component

P00878
type: UnificationXref
id: P00878
db: PANTHER Pathway Component

Complex (Galphaq/GTP)
type: Complex
component stoichiometry: GTP s17 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: Galphaq s16 sa12 STOICHIOMETRY ID COMPLEX
component: GTP
component: Galphaq
feature: COMPLEX BINDING FEATURE s33 a58 1754
feature: COMPLEX BINDING FEATURE s33 a58 1752
cellular location: cytoplasm

P00879
type: UnificationXref
id: P00879
db: PANTHER Pathway Component

Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
type: ProteinReference
xref: uniprot K9J7V0 565
xref: PTHR24347:SF398
organism: Xenopus tropicalis

uniprot F7EEZ1 790
type: UnificationXref
id: F7EEZ1
db: uniprot

P00881
type: UnificationXref
id: P00881
db: PANTHER Pathway Component

C-C motif chemokine 2
type: ProteinReference
xref: uniprot P14844 840
organism: Rattus norvegicus

uniprot P35465 412
type: UnificationXref
id: P35465
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XSJ9 201
organism: Macaca mulatta

uniprot A7F345 83
type: UnificationXref
id: A7F345
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 532
xref: PTHR44329:SF22
xref: uniprot Q99N57 531
organism: Mus musculus

uniprot P14844 840
type: UnificationXref
id: P14844
db: uniprot

Myosin light chain kinase, smooth muscle
type: ProteinReference
xref: uniprot Q15746 1652
xref: PTHR47633:SF1
organism: Homo sapiens

uniprot H2QV01 1581
type: UnificationXref
id: H2QV01
db: uniprot

uniprot F7GEK1 62
type: UnificationXref
id: F7GEK1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FD32 93
organism: Macaca mulatta

Actin-1
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P0DM41 995
organism: Caenorhabditis elegans

C3a anaphylatoxin chemotactic receptor
type: ProteinReference
xref: uniprot O55197 704
xref: PTHR24225:SF28
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MQ37 1273
xref: PTHR45615:SF16
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Arachidonic_acid-RIGHT__Prostaglandin-_r79
controller: Cyclooxygenase

uniprot A0A2J8N697 166
type: UnificationXref
id: A0A2J8N697
db: uniprot

uniprot H2QPQ2 815
type: UnificationXref
id: H2QPQ2
db: uniprot

C-C chemokine receptor type 2
type: ProteinReference
xref: uniprot O55193 703
xref: PTHR10489:SF928
organism: Rattus norvegicus

uniprot A9TYG3 915
type: UnificationXref
id: A9TYG3
db: uniprot

uniprot H2R8U9 600
type: UnificationXref
id: H2R8U9
db: uniprot

uniprot O60262 347
type: UnificationXref
id: O60262
db: uniprot

uniprot P47196 68
type: UnificationXref
id: P47196
db: uniprot

pro-inflammatory genes
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P22694 1165
organism: Homo sapiens

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: uniprot Q60680 1425
organism: Mus musculus

Nuclear factor of activated T cells 2
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot F1MGR9 611
organism: Bos taurus

uniprot P05555 647
type: UnificationXref
id: P05555
db: uniprot

uniprot O97919 827
type: UnificationXref
id: O97919
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot R4GKD1 380
xref: PTHR13809:SF5
organism: Gallus gallus

STATE_TRANSITION_LEFT__IkappaB-RIGHT__IkappaB-_r46
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 1806
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 1807
left: IkappaB
interaction type: STATE_TRANSITION
right: IkappaB

PTHR10709:SF10
type: RelationshipXref
id: PTHR10709:SF10
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 333
xref: PTHR13809:SF19
organism: Macaca mulatta

PTHR10709:SF11
type: RelationshipXref
id: PTHR10709:SF11
db: PANTHER Family
relationship type: By Homology

STAT
type: Protein
entity reference: STAT
feature: ACTIVE 46

C-X-C chemokine receptor type 1
type: ProteinReference
xref: uniprot Q810W6 769
xref: PTHR10489:SF916
organism: Mus musculus

uniprot Q29RC5 242
type: UnificationXref
id: Q29RC5
db: uniprot

uniprot A0A2I3TN41 146
type: UnificationXref
id: A0A2I3TN41
db: uniprot

Guanine nucleotide-binding protein (G protein), q polypeptide
type: ProteinReference
xref: uniprot B8JLJ7 11
organism: Danio rerio

PTHR24055:SF338
type: RelationshipXref
id: PTHR24055:SF338
db: PANTHER Family
relationship type: By Homology

uniprot Q9Z0D9 784
type: UnificationXref
id: Q9Z0D9
db: uniprot

uniprot B8JLJ7 11
type: UnificationXref
id: B8JLJ7
db: uniprot

uniprot A0A2I3SSC7 481
type: UnificationXref
id: A0A2I3SSC7
db: uniprot

uniprot P63000 229
type: UnificationXref
id: P63000
db: uniprot

IL2 s92 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IL2
stoichiometric coefficient: 1.0

PTHR23122:SF7
type: RelationshipXref
id: PTHR23122:SF7
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot W4Y969 1089
xref: PTHR11937:SF453
organism: Strongylocentrotus purpuratus

Uncharacterized protein (Fragment)
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot C3YPV2 1560
organism: Branchiostoma floridae

Rho-associated protein kinase
type: ProteinReference
xref: PTHR22988:SF33
xref: uniprot F6T5Y1 1689
organism: Macaca mulatta

uniprot P85970 1608
type: UnificationXref
id: P85970
db: uniprot

Integrin alpha-L
type: ProteinReference
xref: uniprot P24063 652
xref: PTHR23220:SF84
organism: Mus musculus

uniprot P97545 862
type: UnificationXref
id: P97545
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11339:SF361
xref: uniprot A0A1D5R0L5 1189
organism: Macaca mulatta

uniprot E2RT85 1194
type: UnificationXref
id: E2RT85
db: uniprot

TRANSCRIPTION
type: RelationshipTypeVocabulary

ACTin
type: ProteinReference
xref: PTHR11937:SF359
xref: uniprot O45815 988
organism: Caenorhabditis elegans

C-X-C chemokine receptor type 2
type: ProteinReference
xref: uniprot P35343 722
xref: PTHR10489:SF689
organism: Mus musculus

N-formyl peptide receptor 3 (Fragment)
type: ProteinReference
xref: uniprot P79243 755
organism: Pan troglodytes

fMet-Leu-Phe receptor (Fragment)
type: ProteinReference
xref: uniprot P79241 754
xref: PTHR24225:SF15
organism: Pan troglodytes

C5a anaphylatoxin chemotactic receptor 1
type: ProteinReference
xref: PTHR24225:SF29
xref: uniprot P79240 753
organism: Pan troglodytes

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot A0A2J8QDF6 1440
organism: Pan troglodytes

Novel actin protein
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot Q6IQL9 1064
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot F2Z3T8 318
organism: Rattus norvegicus

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF4
xref: uniprot J9P309 1585
organism: Canis lupus familiaris

uniprot B7PHY7 185
type: UnificationXref
id: B7PHY7
db: uniprot

Serine/threonine-protein kinase PAK 5
type: ProteinReference
xref: uniprot Q9P286 427
organism: Homo sapiens

uniprot P49798 173
type: UnificationXref
id: P49798
db: uniprot

JAK s38 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JAK
stoichiometric coefficient: 2.0

uniprot P51676 733
type: UnificationXref
id: P51676
db: uniprot

Interleukin-8
type: ProteinReference
xref: PTHR10179:SF42
xref: uniprot P79255 857
organism: Bos taurus

Prostaglandin G/H synthase 2
type: ProteinReference
xref: uniprot P35355 537
xref: PTHR11903:SF8
organism: Rattus norvegicus

uniprot F0Z796 951
type: UnificationXref
id: F0Z796
db: uniprot

Prostaglandin G/H synthase 2
type: ProteinReference
xref: uniprot P35354 536
organism: Homo sapiens

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: uniprot A0A2I3T4Q0 1414
organism: Pan troglodytes

uniprot P17181 1241
type: UnificationXref
id: P17181
db: uniprot

uniprot A0A2I3TJ60 606
type: UnificationXref
id: A0A2I3TJ60
db: uniprot

uniprot F1MJV4 467
type: UnificationXref
id: F1MJV4
db: uniprot

uniprot F1MAZ9 610
type: UnificationXref
id: F1MAZ9
db: uniprot

uniprot F1MX21 486
type: UnificationXref
id: F1MX21
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot J9JHK9 1480
xref: PTHR10336:SF11
organism: Canis lupus familiaris

uniprot Q7PXZ8 1073
type: UnificationXref
id: Q7PXZ8
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot P09217 122
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F1MYM3 1362
organism: Bos taurus

uniprot F6UC75 676
type: UnificationXref
id: F6UC75
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF417
xref: uniprot Q6Z437 298
organism: Oryza sativa

uniprot A8XW88 1144
type: UnificationXref
id: A8XW88
db: uniprot

PARTICIPANT STOICHIOMETRY r21 1911
type: Stoichiometry
physical entity: PLCbetagamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r21 1910
type: Stoichiometry
physical entity: PLCbetagamma
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
type: ProteinReference
xref: uniprot Q8R3B1 1520
organism: Mus musculus

Integrin subunit alpha 2
type: ProteinReference
xref: PTHR23220:SF23
xref: uniprot A0A0G2K470 1186
organism: Rattus norvegicus

uniprot F1MRC2 1274
type: UnificationXref
id: F1MRC2
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q10316 1611
organism: Schizosaccharomyces pombe

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F7E2P1 1469
organism: Monodelphis domestica

uniprot Q54GX7 1050
type: UnificationXref
id: Q54GX7
db: uniprot

ncbitaxon 227321 110
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot H2QLZ4 493
type: UnificationXref
id: H2QLZ4
db: uniprot

uniprot F6ZAV4 469
type: UnificationXref
id: F6ZAV4
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Cytokine_receptor-_INFgamma-RIGHT__Complex__Cytokine_receptor_INFgamma_-_r57
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 1886
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 1888
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 1887
left: Cytokine receptor
left: INFgamma
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Cytokine receptor/INFgamma)

uniprot F1LNH3 1196
type: UnificationXref
id: F1LNH3
db: uniprot

uniprot A8XQS8 183
type: UnificationXref
id: A8XQS8
db: uniprot

PTHR12058:SF0
type: RelationshipXref
id: PTHR12058:SF0
db: PANTHER Family
relationship type: By Homology

Complex (CHKR/CHK)
type: Complex
component stoichiometry: CHKR s207 sa159 STOICHIOMETRY ID COMPLEX
component stoichiometry: CHK s208 sa160 STOICHIOMETRY ID COMPLEX
component: CHK
component: CHKR
feature: COMPLEX BINDING FEATURE s24 csa17 1714
feature: COMPLEX BINDING FEATURE s24 csa17 1716
cellular location: cytoplasm

uniprot P53712 656
type: UnificationXref
id: P53712
db: uniprot

C-C motif chemokine
type: ProteinReference
xref: uniprot F1PSD3 804
organism: Canis lupus familiaris

uniprot P30355 138
type: UnificationXref
id: P30355
db: uniprot

uniprot F5HMB9 1459
type: UnificationXref
id: F5HMB9
db: uniprot

Cytokine receptor
type: Protein
entity reference: Cytokine receptor
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

IP3R
type: Protein
entity reference: IP3R
feature: ACTIVE 46
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot Q9DAS9 377
type: UnificationXref
id: Q9DAS9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r75
controller: Ras

uniprot F1PL90 1454
type: UnificationXref
id: F1PL90
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: uniprot F6ZAV4 469
xref: PTHR45627:SF6
organism: Ornithorhynchus anatinus

IkappaB s108 sa50 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IkappaB
stoichiometric coefficient: 1.0

Probable actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot P58798 1604
organism: Caenorhabditis elegans

uniprot Q9VXH3 1530
type: UnificationXref
id: Q9VXH3
db: uniprot

uniprot P20291 134
type: UnificationXref
id: P20291
db: uniprot

uniprot P0CY33 211
type: UnificationXref
id: P0CY33
db: uniprot

uniprot Q17850 416
type: UnificationXref
id: Q17850
db: uniprot

uniprot P32248 718
type: UnificationXref
id: P32248
db: uniprot

cAMP-dependent protein kinase, catalytic subunit-like
type: ProteinReference
xref: uniprot A8XJQ6 1143
xref: PTHR24353:SF37
organism: Caenorhabditis briggsae

uniprot F7EZT2 92
type: UnificationXref
id: F7EZT2
db: uniprot

uniprot Q9UVF3 1086
type: UnificationXref
id: Q9UVF3
db: uniprot

Collagen alpha-3(VI) chain
type: ProteinReference
xref: PTHR24020:SF13
xref: uniprot P15989 1215
organism: Gallus gallus

Collagen alpha-2(VI) chain
type: ProteinReference
xref: PTHR24020:SF29
xref: uniprot P15988 1214
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G4Q0 1148
xref: PTHR24353:SF82
organism: Monodelphis domestica

uniprot Q6DV79 163
type: UnificationXref
id: Q6DV79
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1MYJ4 54
xref: PTHR24356:SF190
organism: Bos taurus

ncbitaxon 6669 195
type: UnificationXref
id: 6669
db: ncbitaxon

ncbitaxon 3218 913
type: UnificationXref
id: 3218
db: ncbitaxon

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot O54857 592
xref: PTHR12305:SF81
organism: Rattus norvegicus

ncbitaxon 13616 20
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot A8Y4R0 911
type: UnificationXref
id: A8Y4R0
db: uniprot

Beta-adrenergic receptor kinase 1
type: ProteinReference
xref: uniprot Q99MK8 463
xref: PTHR24355:SF22
organism: Mus musculus

RELA isoform 1
type: ProteinReference
xref: uniprot G2HHW9 1101
organism: Pan troglodytes

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

uniprot F6Z7T2 615
type: UnificationXref
id: F6Z7T2
db: uniprot

PTHR24055:SF391
type: RelationshipXref
id: PTHR24055:SF391
db: PANTHER Family
relationship type: By Homology

uniprot Q17941 70
type: UnificationXref
id: Q17941
db: uniprot

uniprot G3UW82 1304
type: UnificationXref
id: G3UW82
db: uniprot

uniprot Q9R0T8 1429
type: UnificationXref
id: Q9R0T8
db: uniprot

uniprot P45891 1006
type: UnificationXref
id: P45891
db: uniprot

Complex (Cytokine receptor/JAK/ JAK/INFgamma)
type: Complex
component stoichiometry: JAK s38 sa23 STOICHIOMETRY ID COMPLEX
component stoichiometry: INFgamma s45 sa25 STOICHIOMETRY ID COMPLEX
component: Cytokine receptor
component: JAK
component: INFgamma
feature: COMPLEX BINDING FEATURE s112 a163 1770
feature: COMPLEX BINDING FEATURE s112 a163 1768
feature: COMPLEX BINDING FEATURE s112 a163 1772
cellular location: cytoplasm

Leishmania major
type: BioSource
xref: ncbitaxon 5664 1085

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot H2QNG6 1375
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1Q4F8 56
xref: PTHR24356:SF190
organism: Canis lupus familiaris

uniprot A1XG22 1094
type: UnificationXref
id: A1XG22
db: uniprot

uniprot Q80X19 1222
type: UnificationXref
id: Q80X19
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TUR3 965
xref: PTHR11937:SF192
organism: Monodelphis domestica

uniprot Q28519 760
type: UnificationXref
id: Q28519
db: uniprot

uniprot P50150 353
type: UnificationXref
id: P50150
db: uniprot

uniprot P97884 863
type: UnificationXref
id: P97884
db: uniprot

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot A0A0G2K3R1 1226
organism: Rattus norvegicus

INFgamma
type: Protein
entity reference: INFgamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa25 1773
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Myosin heavy chain 4
type: ProteinReference
xref: PTHR45615:SF44
xref: uniprot A2BGX6 1260
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GE67 1302
xref: PTHR46256:SF1
organism: Macaca mulatta

PTHR10489:SF773
type: RelationshipXref
id: PTHR10489:SF773
db: PANTHER Family
relationship type: By Homology

uniprot F2Z3T8 318
type: UnificationXref
id: F2Z3T8
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot F7ERP8 332
organism: Ornithorhynchus anatinus

uniprot F7FN72 1576
type: UnificationXref
id: F7FN72
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6VPY1 323
xref: PTHR13809:SF25
organism: Ornithorhynchus anatinus

Muscle-specific actin
type: ProteinReference
xref: PTHR11937:SF162
xref: uniprot E9FRT1 947
organism: Daphnia pulex

Serine/threonine-protein kinase PAK 2
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot Q13177 415
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot F7DQK7 975
organism: Monodelphis domestica

uniprot F7BAS2 402
type: UnificationXref
id: F7BAS2
db: uniprot

Actin 7
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9TBG2 912
organism: Physcomitrella patens

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot Q5ZJI7 1622
organism: Gallus gallus

uniprot Q99N57 531
type: UnificationXref
id: Q99N57
db: uniprot

uniprot P93738 1043
type: UnificationXref
id: P93738
db: uniprot

cAMP-dependent protein kinase catalytic subunit TPK2
type: ProteinReference
xref: uniprot A0A0D1DSN6 1141
xref: PTHR24353:SF117
organism: Ustilago maydis

uniprot Q9JLA2 1413
type: UnificationXref
id: Q9JLA2
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta isoform 1
type: ProteinReference
xref: uniprot F7EBQ5 1147
xref: PTHR24353:SF116
organism: Macaca mulatta

Complex (CHKR/CHK)
type: Complex
component stoichiometry: CHKR s207 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: CHK s208 sa11 STOICHIOMETRY ID COMPLEX
component: CHKR
component: CHK
feature: COMPLEX BINDING FEATURE s24 a40 1710
feature: COMPLEX BINDING FEATURE s24 a40 1712
cellular location: cytoplasm

Peripheral plasma membrane protein CASK
type: ProteinReference
xref: PTHR23122:SF7
xref: uniprot Q24210 574
organism: Drosophila melanogaster

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q5KP06 1055
organism: Cryptococcus neoformans

INFgamma s45 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: INFgamma
stoichiometric coefficient: 1.0

uniprot F6R543 488
type: UnificationXref
id: F6R543
db: uniprot

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot Q5E9B5 1054
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Arp2_3-RIGHT__Arp2_3-_r37
controller: Rac

Adenylate cyclase type 5
type: ProteinReference
xref: PTHR45627:SF7
xref: uniprot Q04400 478
organism: Rattus norvegicus

ATP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

C-X-C chemokine receptor type 4
type: ProteinReference
xref: PTHR10489:SF594
xref: uniprot O08565 697
organism: Rattus norvegicus

RAS related
type: ProteinReference
xref: uniprot K7CW85 1401
xref: PTHR24070:SF245
organism: Pan troglodytes

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 520
xref: PTHR44329:SF22
xref: uniprot P04049 518
organism: Homo sapiens

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF7
xref: uniprot E1BHU9 466
organism: Bos taurus

uniprot P63269 1028
type: UnificationXref
id: P63269
db: uniprot

uniprot B8A569 1268
type: UnificationXref
id: B8A569
db: uniprot

PTHR24356:SF170
type: RelationshipXref
id: PTHR24356:SF170
db: PANTHER Family
relationship type: By Homology

uniprot P63034 1544
type: UnificationXref
id: P63034
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3YJC1 187
organism: Branchiostoma floridae

IFNAR1 isoform 2
type: ProteinReference
xref: uniprot H2QKY9 1238
xref: PTHR20859:SF54
organism: Pan troglodytes

uniprot A0A1D5QUZ8 262
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

Leukotriene B4 receptor 2
type: ProteinReference
xref: PTHR24230:SF8
xref: uniprot Q9NPC1 777
organism: Homo sapiens

uniprot P40977 1495
type: UnificationXref
id: P40977
db: uniprot

uniprot O14920 1422
type: UnificationXref
id: O14920
db: uniprot

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

Regulator of G-protein signaling 18
type: ProteinReference
xref: PTHR10845:SF155
xref: uniprot Q99PG4 177
organism: Mus musculus

PTHR24356:SF176
type: RelationshipXref
id: PTHR24356:SF176
db: PANTHER Family
relationship type: By Homology

uniprot E9FRT1 947
type: UnificationXref
id: E9FRT1
db: uniprot

ncbitaxon 185431 1048
type: UnificationXref
id: 185431
db: ncbitaxon

uniprot P31751 67
type: UnificationXref
id: P31751
db: uniprot

Cdc42
type: Protein
entity reference: Cdc42
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P17535 444
type: UnificationXref
id: P17535
db: uniprot

uniprot Q62245 602
type: UnificationXref
id: Q62245
db: uniprot

uniprot Q12968 623
type: UnificationXref
id: Q12968
db: uniprot

uniprot Q10AZ4 1045
type: UnificationXref
id: Q10AZ4
db: uniprot

uniprot H2QFK0 1151
type: UnificationXref
id: H2QFK0
db: uniprot

uniprot F6ZHU6 1295
type: UnificationXref
id: F6ZHU6
db: uniprot

Phospholipase A2
type: ProteinReference
evidence: Evidence 786
xref: uniprot F7CBU9 789
xref: PTHR10728:SF13
organism: Monodelphis domestica

uniprot E2RGD0 1671
type: UnificationXref
id: E2RGD0
db: uniprot

uniprot Q61879 1337
type: UnificationXref
id: Q61879
db: uniprot

PTHR11937:SF201
type: RelationshipXref
id: PTHR11937:SF201
db: PANTHER Family
relationship type: By Homology

uniprot F7BIC2 1131
type: UnificationXref
id: F7BIC2
db: uniprot

uniprot O61861 1591
type: UnificationXref
id: O61861
db: uniprot

uniprot H2QNG6 1375
type: UnificationXref
id: H2QNG6
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P60010 1013
organism: Saccharomyces cerevisiae

uniprot P63213 361
type: UnificationXref
id: P63213
db: uniprot

uniprot P63001 230
type: UnificationXref
id: P63001
db: uniprot

uniprot Q9U1E8 1084
type: UnificationXref
id: Q9U1E8
db: uniprot

uniprot Q7YTV5 1074
type: UnificationXref
id: Q7YTV5
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: PTHR12644:SF1
xref: uniprot F6X9N6 1572
organism: Monodelphis domestica

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P17612 1163
organism: Homo sapiens

uniprot F6WVV6 1538
type: UnificationXref
id: F6WVV6
db: uniprot

Protein tyrosine kinase 2 beta
type: ProteinReference
xref: uniprot F6Z395 630
xref: PTHR24418:SF94
organism: Monodelphis domestica

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot O08586 591
xref: PTHR12305:SF81
organism: Mus musculus

uniprot Q6DF43 373
type: UnificationXref
id: Q6DF43
db: uniprot

PTHR24356:SF190
type: RelationshipXref
id: PTHR24356:SF190
db: PANTHER Family
relationship type: By Homology

uniprot Q58CQ2 1620
type: UnificationXref
id: Q58CQ2
db: uniprot

uniprot A0A2I3THL4 510
type: UnificationXref
id: A0A2I3THL4
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot Q14643 502
organism: Homo sapiens

Integrin subunit alpha 9
type: ProteinReference
xref: PTHR23220:SF69
xref: uniprot F6T4B4 643
organism: Macaca mulatta

Cell division cycle 42
type: ProteinReference
xref: uniprot Q28BZ0 241
xref: PTHR24072:SF136
organism: Xenopus tropicalis

Myosin heavy chain 2
type: ProteinReference
xref: uniprot H2QC99 1308
xref: PTHR45615:SF39
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot H2QC98 1307
xref: PTHR45615:SF35
organism: Pan troglodytes

Myosin heavy chain 13
type: ProteinReference
xref: PTHR45615:SF44
xref: uniprot H2QC97 1306
organism: Pan troglodytes

uniprot H9ERN5 1679
type: UnificationXref
id: H9ERN5
db: uniprot

Ca2+
type: SmallMolecule
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=ION

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot Q6P640 1067
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR10489:SF635
xref: uniprot F6WHR2 678
organism: Macaca mulatta

Os05g0106600 protein
type: ProteinReference
xref: PTHR11937:SF464
xref: uniprot Q65XH8 1060
organism: Oryza sativa

STATE_TRANSITION_LEFT__PLCbetagamma-RIGHT__PLCbetagamma-_r21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 1910
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 1911
left: PLCbetagamma
interaction type: STATE_TRANSITION
right: PLCbetagamma

uniprot P83967 1040
type: UnificationXref
id: P83967
db: uniprot

Integrin subunit alpha 9
type: ProteinReference
xref: PTHR23220:SF69
xref: uniprot D3ZN51 640
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re73 1848
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

uniprot F1RCB6 956
type: UnificationXref
id: F1RCB6
db: uniprot

PARTICIPANT STOICHIOMETRY re73 1849
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

uniprot K7DKR3 619
type: UnificationXref
id: K7DKR3
db: uniprot

uniprot Q9Z329 504
type: UnificationXref
id: Q9Z329
db: uniprot

Evidence 786
type: Evidence
evidence code: ISS
comment: SPACC P50393

uniprot F1MYJ4 54
type: UnificationXref
id: F1MYJ4
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A0A1D5QXV8 1434
organism: Macaca mulatta

Rho
type: Protein
entity reference: Rho
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Collagen type VI alpha 2 chain
type: ProteinReference
xref: uniprot H2QL58 1206
xref: PTHR24020:SF29
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r69 1837
type: Stoichiometry
physical entity: Shc
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r69 1838
type: Stoichiometry
physical entity: Grb
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r69 1839
type: Stoichiometry
physical entity: Complex (Shc/Sos/ Grb)
stoichiometric coefficient: 1.0

uniprot F7BD45 1297
type: UnificationXref
id: F7BD45
db: uniprot

DISSOCIATION_LEFT__Complex__CHKR_CHK__Galphai_q__GDP_Gbetagamma_-_GTP-RIGHT__Complex__Galphai_q__GTP_-_Complex__CHKR_CHK_-_GDP-_Gbetagamma-_r5
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 1799
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 1794
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 1795
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 1797
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 1796
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 1798
left: GTP
left: Complex (CHKR/CHK/ Galphai/q/ GDP/Gbetagamma)
interaction type: DISSOCIATION
right: Complex (Galphai/q/ GTP)
right: Gbetagamma
right: GDP
right: Complex (CHKR/CHK)

IkappaB s200 a133 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.25
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY r69 1836
type: Stoichiometry
physical entity: Sos
stoichiometric coefficient: 1.0

Leukotriene
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot Q95KV0 1426
xref: PTHR22969:SF7
organism: Bos taurus

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: uniprot Q95KV1 1427
organism: Bos taurus

uniprot Q1JP79 1614
type: UnificationXref
id: Q1JP79
db: uniprot

Evidence 799
type: Evidence
evidence code: IEA
comment: SPACC P50393

STATE_TRANSITION_LEFT__Cdc42-RIGHT__Cdc42-_r33
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1851
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1850
left: Cdc42
interaction type: STATE_TRANSITION
right: Cdc42

PTHR10663:SF363
type: RelationshipXref
id: PTHR10663:SF363
db: PANTHER Family
relationship type: By Homology

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot Q05062 236
organism: Caenorhabditis elegans

Actin, alpha 2, smooth muscle, aorta
type: ProteinReference
xref: uniprot Q5M8T9 1057
xref: PTHR11937:SF445
organism: Xenopus tropicalis

uniprot F1LQH2 1096
type: UnificationXref
id: F1LQH2
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 508
evidence: Evidence 507
evidence: Evidence 506
evidence: Evidence 509
xref: PTHR44329:SF22
xref: uniprot A0A1D5R9U8 505
organism: Macaca mulatta

Collagen type VI alpha 1 chain
type: ProteinReference
xref: PTHR24020:SF18
xref: uniprot E1BI98 1193
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MDX9 588
xref: PTHR12305:SF81
organism: Bos taurus

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: uniprot O88656 1593
xref: PTHR10709:SF10
organism: Rattus norvegicus

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: uniprot Q58CQ2 1620
xref: PTHR10709:SF10
organism: Bos taurus

uniprot A0A1D5Q5Z6 261
type: UnificationXref
id: A0A1D5Q5Z6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__F_actin-RIGHT__F_actin-_r39
controller: PAK

IkappaB s200 a133 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Actin-2
type: ProteinReference
xref: PTHR11937:SF410
xref: uniprot A3C6D7 895
organism: Oryza sativa

Galphai/q
type: Protein
entity reference: Galphai/q
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa2 1705
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P59999 1606
type: UnificationXref
id: P59999
db: uniprot

uniprot O94916 620
type: UnificationXref
id: O94916
db: uniprot

uniprot A0A2I3TX94 660
type: UnificationXref
id: A0A2I3TX94
db: uniprot

uniprot P51682 739
type: UnificationXref
id: P51682
db: uniprot

uniprot P55249 141
type: UnificationXref
id: P55249
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TFK0 674
xref: PTHR24230:SF8
organism: Macaca mulatta

ncbitaxon 36329 1079
type: UnificationXref
id: 36329
db: ncbitaxon

Protein tyrosine kinase 2 beta
type: ProteinReference
xref: uniprot E2QTG4 629
xref: PTHR24418:SF94
organism: Canis lupus familiaris

uniprot H2QZG8 1310
type: UnificationXref
id: H2QZG8
db: uniprot

Raf homolog serine/threonine-protein kinase Raf
type: ProteinReference
xref: uniprot P11346 527
organism: Drosophila melanogaster

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: uniprot E2RNA9 1417
organism: Canis lupus familiaris

RAS related
type: ProteinReference
xref: uniprot E2R5G6 1397
xref: PTHR24070:SF245
organism: Canis lupus familiaris

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 526
xref: PTHR44329:SF22
xref: uniprot P11345 525
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r23
controller: Ca2+

PTHR10663:SF343
type: RelationshipXref
id: PTHR10663:SF343
db: PANTHER Family
relationship type: By Homology

uniprot F6Y1J3 806
type: UnificationXref
id: F6Y1J3
db: uniprot

PTHR24356:SF159
type: RelationshipXref
id: PTHR24356:SF159
db: PANTHER Family
relationship type: By Homology

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q9VQD8 1640
xref: PTHR12644:SF0
organism: Drosophila melanogaster

uniprot A0A2J8KQU9 125
type: UnificationXref
id: A0A2J8KQU9
db: uniprot

PTHR24356:SF158
type: RelationshipXref
id: PTHR24356:SF158
db: PANTHER Family
relationship type: By Homology

uniprot W4ZD41 1090
type: UnificationXref
id: W4ZD41
db: uniprot

uniprot H2QEP3 1677
type: UnificationXref
id: H2QEP3
db: uniprot

uniprot P02776 828
type: UnificationXref
id: P02776
db: uniprot

STATE_TRANSITION_LEFT__F_actin-RIGHT__F_actin-_r39
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 1833
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 1832
left: F-actin
interaction type: STATE_TRANSITION
right: F-actin

uniprot A0A3Q1LVP1 628
type: UnificationXref
id: A0A3Q1LVP1
db: uniprot

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: uniprot O96623 1595
organism: Dictyostelium discoideum

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot O96624 1596
xref: PTHR12391:SF0
organism: Dictyostelium discoideum

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: uniprot O96625 1597
xref: PTHR22629:SF0
organism: Dictyostelium discoideum

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XZ13 935
organism: Branchiostoma floridae

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot O96626 1598
xref: PTHR12644:SF0
organism: Dictyostelium discoideum

C-X3-C motif chemokine receptor 1
type: ProteinReference
xref: PTHR10489:SF637
xref: uniprot H2RCA7 691
organism: Pan troglodytes

Actin-related protein 2/3 complex subunit 1
type: ProteinReference
xref: PTHR10709:SF2
xref: uniprot O96622 1594
organism: Dictyostelium discoideum

CHK
type: Protein
entity reference: CHK
feature: COMPLEX PARTICIPANT BINDING FEATURE s208 sa11 1713
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
type: ProteinReference
xref: PTHR22829:SF6
xref: uniprot J9NRL7 1541
organism: Canis lupus familiaris

uniprot K7DK66 1402
type: UnificationXref
id: K7DK66
db: uniprot

uniprot F7ASR8 328
type: UnificationXref
id: F7ASR8
db: uniprot

uniprot P17612 1163
type: UnificationXref
id: P17612
db: uniprot

uniprot P21708 279
type: UnificationXref
id: P21708
db: uniprot

GDP s11 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot K7DDW5 618
type: UnificationXref
id: K7DDW5
db: uniprot

MAPK s162 a236 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot C3XYC4 928
type: UnificationXref
id: C3XYC4
db: uniprot

uniprot H2R3F1 1208
type: UnificationXref
id: H2R3F1
db: uniprot

PTHR24356:SF163
type: RelationshipXref
id: PTHR24356:SF163
db: PANTHER Family
relationship type: By Homology

uniprot Q15746 1652
type: UnificationXref
id: Q15746
db: uniprot

uniprot Q14571 500
type: UnificationXref
id: Q14571
db: uniprot

Cytokine receptor s99 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cytokine receptor
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot O88643 410
organism: Mus musculus

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot Q1LYG2 530
organism: Danio rerio

uniprot P46092 727
type: UnificationXref
id: P46092
db: uniprot

uniprot F7BYN4 155
type: UnificationXref
id: F7BYN4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ALP1 972
xref: PTHR11937:SF192
organism: Monodelphis domestica

uniprot E1BS97 389
type: UnificationXref
id: E1BS97
db: uniprot

PTHR45615:SF11
type: RelationshipXref
id: PTHR45615:SF11
db: PANTHER Family
relationship type: By Homology

Lipoxygenase
type: ProteinReference
xref: P00830
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.Lipoxygenase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Lipoxygenase Synonym: Synonym not specified Accession: P00830
member entity reference: Arachidonate 12-lipoxygenase, epidermal-type
member entity reference: Arachidonate 5-lipoxygenase-activating protein
member entity reference: Arachidonate 15-lipoxygenase
member entity reference: ALOX15 isoform 1
member entity reference: Leukotriene C4 synthase
member entity reference: ALOX5AP isoform 2
member entity reference: Uncharacterized protein
member entity reference: Arachidonate 12-lipoxygenase, 12S-type
member entity reference: ALOX12 isoform 2
member entity reference: Arachidonate 5-lipoxygenase-activating protein (Fragment)

uniprot O18840 986
type: UnificationXref
id: O18840
db: uniprot

uniprot E9FZ00 949
type: UnificationXref
id: E9FZ00
db: uniprot

uniprot Q00653 1105
type: UnificationXref
id: Q00653
db: uniprot

uniprot H2QX72 817
type: UnificationXref
id: H2QX72
db: uniprot

uniprot P10145 831
type: UnificationXref
id: P10145
db: uniprot

uniprot P84095 231
type: UnificationXref
id: P84095
db: uniprot

Collagen type VI alpha 1 chain
type: ProteinReference
xref: uniprot D3ZUL3 1191
xref: PTHR24023:SF917
organism: Rattus norvegicus

Interleukin-1 beta
type: ProteinReference
xref: uniprot P10749 1410
organism: Mus musculus

uniprot D3Z9H7 607
type: UnificationXref
id: D3Z9H7
db: uniprot

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot Q9TU25 258
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E1BA03 388
organism: Bos taurus

uniprot F7EBQ5 1147
type: UnificationXref
id: F7EBQ5
db: uniprot

uniprot F1MDX9 588
type: UnificationXref
id: F1MDX9
db: uniprot

uniprot F7FD93 563
type: UnificationXref
id: F7FD93
db: uniprot

uniprot O95644 621
type: UnificationXref
id: O95644
db: uniprot

uniprot D3ZN51 640
type: UnificationXref
id: D3ZN51
db: uniprot

uniprot F7BVQ1 1467
type: UnificationXref
id: F7BVQ1
db: uniprot

uniprot Q3ULB5 418
type: UnificationXref
id: Q3ULB5
db: uniprot

Actin-1
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q8I4X0 1078
organism: Plasmodium falciparum

ALOX12 isoform 2
type: ProteinReference
xref: PTHR11771:SF4
xref: uniprot H2QC17 131
organism: Pan troglodytes

C-C motif chemokine
type: ProteinReference
xref: PTHR12015:SF102
xref: uniprot A0A2I3SMD5 801
organism: Pan troglodytes

uniprot D3ZRN3 944
type: UnificationXref
id: D3ZRN3
db: uniprot

PKC
type: Protein
entity reference: PKC
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot Q9DC51 118
organism: Mus musculus

Regulator of G-protein signaling 14
type: ProteinReference
xref: PTHR45945:SF2
xref: uniprot P97492 175
organism: Mus musculus

uniprot P42161 1662
type: UnificationXref
id: P42161
db: uniprot

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF15
xref: uniprot F6X9W7 457
organism: Canis lupus familiaris

ncbitaxon 284811 257
type: UnificationXref
id: 284811
db: ncbitaxon

uniprot C3ZTX6 943
type: UnificationXref
id: C3ZTX6
db: uniprot

Complex (Cytokine receptor/JAK/ JAK/STAT/ INFgamma)
type: Complex
component stoichiometry: INFgamma s79 sa30 STOICHIOMETRY ID COMPLEX
component stoichiometry: STAT s78 sa29 STOICHIOMETRY ID COMPLEX
component stoichiometry: JAK s70 sa27 STOICHIOMETRY ID COMPLEX
component: INFgamma
component: Cytokine receptor
component: JAK
component: STAT
feature: COMPLEX BINDING FEATURE s118 a173 1696
feature: COMPLEX BINDING FEATURE s118 a173 1698
feature: COMPLEX BINDING FEATURE s118 a173 1700
feature: COMPLEX BINDING FEATURE s118 a173 1694
cellular location: cytoplasm

uniprot Q8K4S1 1519
type: UnificationXref
id: Q8K4S1
db: uniprot

JunB proto-oncogene, AP-1 transcription factor subunit b
type: ProteinReference
xref: uniprot A0A0R4IAV4 429
xref: PTHR11462:SF37
organism: Danio rerio

ncbitaxon 237631 260
type: UnificationXref
id: 237631
db: ncbitaxon

INHIBITION
type: Control
xref: INHIBITION
controlled: UNKNOWN_TRANSITION_LEFT__Complex__Galphai_q__GTP_-RIGHT__Complex__Galphaq_GTP_-_r7
control type: INHIBITION
controller: RGS

PKC
type: Protein
entity reference: PKC
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Myosin, heavy polypeptide 13, skeletal muscle
type: ProteinReference
xref: PTHR45615:SF44
xref: uniprot B1AR69 1264
organism: Mus musculus

Grb
type: ProteinReference
xref: P00848
standard name: Growth factor receptor-bound protein
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.Grb
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Growth factor receptor-bound protein Synonym: ASH,Abundant SRC homology,Grb Accession: P00848
member entity reference: GRB2-related adaptor protein
member entity reference: GRB2-related adapter protein
member entity reference: GRB2-related adaptor protein 2
member entity reference: Growth factor receptor-bound protein 2a

uniprot P63258 1022
type: UnificationXref
id: P63258
db: uniprot

von Willebrand factor
type: ProteinReference
xref: PTHR11339:SF361
xref: uniprot G1K2B9 1203
organism: Canis lupus familiaris

uniprot H9FU38 495
type: UnificationXref
id: H9FU38
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GU82 1470
organism: Macaca mulatta

uniprot Q01112 233
type: UnificationXref
id: Q01112
db: uniprot

PARTICIPANT STOICHIOMETRY r77 1809
type: Stoichiometry
physical entity: MAPK
stoichiometric coefficient: 1.0

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1M324 1450
organism: Rattus norvegicus

Nuclear factor kappaB subunit p65
type: ProteinReference
xref: uniprot Q7TQN4 1112
organism: Rattus norvegicus

uniprot Q9JLT0 1350
type: UnificationXref
id: Q9JLT0
db: uniprot

uniprot Q15111 1501
type: UnificationXref
id: Q15111
db: uniprot

INFgamma
type: ProteinReference
xref: P00878
standard name: Interferon gamma
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.INF_gamma_
comment: ENTITY_REFERENCE_NOTES=Long Name: Interferon gamma Synonym: Synonym not specified Accession: P00878
member entity reference: Interferon gamma

PTHR24169:SF9
type: RelationshipXref
id: PTHR24169:SF9
db: PANTHER Family
relationship type: By Homology

uniprot F7GGR0 1539
type: UnificationXref
id: F7GGR0
db: uniprot

uniprot F6ZC55 1465
type: UnificationXref
id: F6ZC55
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24020:SF17
xref: uniprot A0A1D5Q4K0 1188
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r81 1783
type: Stoichiometry
physical entity: Arachidonic acid
stoichiometric coefficient: 1.0

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: uniprot A7RRG4 1553
xref: PTHR22629:SF0
organism: Nematostella vectensis

uniprot A0A3Q2UD13 483
type: UnificationXref
id: A0A3Q2UD13
db: uniprot

PTHR24169:SF4
type: RelationshipXref
id: PTHR24169:SF4
db: PANTHER Family
relationship type: By Homology

VWF isoform 2
type: ProteinReference
xref: PTHR11339:SF361
xref: uniprot H2Q597 1204
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r81 1782
type: Stoichiometry
physical entity: Plasma membrane phospholipid
stoichiometric coefficient: 1.0

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: uniprot A8XSM9 1556
xref: PTHR22629:SF0
organism: Caenorhabditis briggsae

PKCzeta
type: Protein
entity reference: PKCzeta
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Platelet factor 4 variant
type: ProteinReference
xref: uniprot P10720 834
xref: PTHR10179:SF38
organism: Homo sapiens

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 303

uniprot Q9Y243 80
type: UnificationXref
id: Q9Y243
db: uniprot

uniprot Q99PG4 177
type: UnificationXref
id: Q99PG4
db: uniprot

uniprot F7A7I3 971
type: UnificationXref
id: F7A7I3
db: uniprot

uniprot C4M5Z7 192
type: UnificationXref
id: C4M5Z7
db: uniprot

uniprot F1PLB3 1456
type: UnificationXref
id: F1PLB3
db: uniprot

JAK
type: Protein
entity reference: JAK
feature: COMPLEX PARTICIPANT BINDING FEATURE s90 sa39 1739
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

CX3C chemokine receptor 1
type: ProteinReference
xref: PTHR10489:SF637
xref: uniprot P49238 730
organism: Homo sapiens

uniprot F1LNF0 1271
type: UnificationXref
id: F1LNF0
db: uniprot

MEK s198 a240 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P53497 1011
type: UnificationXref
id: P53497
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r27
controller: Ras

Actin-10
type: ProteinReference
xref: PTHR11937:SF421
xref: uniprot Q54GX7 1050
organism: Dictyostelium discoideum

uniprot F7F3S0 1369
type: UnificationXref
id: F7F3S0
db: uniprot

uniprot A4IFL6 309
type: UnificationXref
id: A4IFL6
db: uniprot

INFgamma s79 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: INFgamma
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase mpk-1
type: ProteinReference
xref: uniprot P39745 283
xref: PTHR24055:SF158
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r77 1808
type: Stoichiometry
physical entity: MAPK
stoichiometric coefficient: 1.0

Complex (Integrin/EMC)
type: Complex
component stoichiometry: Integrin s23 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: EMC s26 sa19 STOICHIOMETRY ID COMPLEX
component: Integrin
component: EMC
feature: COMPLEX BINDING FEATURE s80 a125 1734
feature: COMPLEX BINDING FEATURE s80 a125 1732
cellular location: cytoplasm

Uncharacterized protein
type: ProteinReference
xref: uniprot F1P1X4 487
xref: PTHR13715:SF53
organism: Gallus gallus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot E2REH3 393
organism: Canis lupus familiaris

Myosin heavy chain 10
type: ProteinReference
xref: PTHR45615:SF24
xref: uniprot F7E4E2 1298
organism: Monodelphis domestica

Calcium/calmodulin-dependent protein kinase type II subunit delta
type: ProteinReference
xref: uniprot Q13557 573
xref: PTHR24347:SF365
organism: Homo sapiens

C-X-C chemokine receptor type 6
type: ProteinReference
xref: uniprot Q9EQ16 773
xref: PTHR10489:SF705
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7D8G7 1675
xref: PTHR10155:SF5
organism: Macaca mulatta

uniprot A1L108 1552
type: UnificationXref
id: A1L108
db: uniprot

uniprot P63215 363
type: UnificationXref
id: P63215
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q8UUX0 77
xref: PTHR24356:SF176
organism: Danio rerio

Integrin subunit alpha 4
type: ProteinReference
xref: uniprot D3ZMQ3 639
xref: PTHR23220:SF78
organism: Rattus norvegicus

uniprot D4A0I8 609
type: UnificationXref
id: D4A0I8
db: uniprot

JAK
type: Protein
entity reference: JAK
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F6VXG1 1365
type: UnificationXref
id: F6VXG1
db: uniprot

uniprot D3ZMQ3 639
type: UnificationXref
id: D3ZMQ3
db: uniprot

Collagen type XIV alpha 1 chain
type: ProteinReference
xref: PTHR24020:SF15
xref: uniprot E1BA17 1192
organism: Bos taurus

Calcium/calmodulin-dependent protein kinase type II subunit beta
type: ProteinReference
xref: PTHR24347:SF403
xref: uniprot P28652 571
organism: Mus musculus

Pristionchus pacificus
type: BioSource
xref: ncbitaxon 54126 209

CHKR
type: Protein
entity reference: CHKR
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 1703
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P63212 360
type: UnificationXref
id: P63212
db: uniprot

IL2
type: ProteinReference
xref: P00870
standard name: Interleukin 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Interleukin 2 Synonym: Synonym not specified Accession: P00870
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.IL2
member entity reference: Lymphotoxin-alpha
member entity reference: Interleukin-36 alpha
member entity reference: Interleukin-1 beta
member entity reference: Interleukin-15
member entity reference: Interleukin-6

uniprot Q6NVA9 1065
type: UnificationXref
id: Q6NVA9
db: uniprot

Signal transducer and activator of transcription 3
type: ProteinReference
xref: uniprot P42227 159
xref: PTHR11801:SF2
organism: Mus musculus

Signal transducer and activator of transcription 1
type: ProteinReference
xref: uniprot P42225 158
xref: PTHR11801:SF18
organism: Mus musculus

uniprot A8KBH6 1128
type: UnificationXref
id: A8KBH6
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q8BTI9 1390
xref: PTHR10048:SF33
organism: Mus musculus

Rac
type: Protein
entity reference: Rac
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 508
evidence: Evidence 507
evidence: Evidence 506
evidence: Evidence 509
xref: PTHR44329:SF22
xref: uniprot E2REI6 513
organism: Canis lupus familiaris

G protein-coupled receptor kinase 6
type: ProteinReference
xref: uniprot O70293 459
xref: PTHR24355:SF15
organism: Mus musculus

G protein subunit alpha o1
type: ProteinReference
xref: uniprot A0A2I3TFM8 82
organism: Pan troglodytes

uniprot A0A1D5R8E9 1435
type: UnificationXref
id: A0A1D5R8E9
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot Q9CXP8 376
organism: Mus musculus

uniprot F1A175 953
type: UnificationXref
id: F1A175
db: uniprot

uniprot A7E2Y1 1263
type: UnificationXref
id: A7E2Y1
db: uniprot

uniprot Q32PX6 243
type: UnificationXref
id: Q32PX6
db: uniprot

uniprot A9JTC8 85
type: UnificationXref
id: A9JTC8
db: uniprot

uniprot O89093 826
type: UnificationXref
id: O89093
db: uniprot

Calcium/calmodulin-dependent protein kinase type II
type: ProteinReference
xref: uniprot O62305 567
xref: PTHR24347:SF412
organism: Caenorhabditis elegans

G protein subunit alpha q
type: ProteinReference
xref: uniprot E1BA29 13
organism: Bos taurus

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot A0A1D5QG31 5
organism: Macaca mulatta

uniprot O89040 1483
type: UnificationXref
id: O89040
db: uniprot

uniprot A0A0G2JTY4 603
type: UnificationXref
id: A0A0G2JTY4
db: uniprot

C-C chemokine receptor type 5
type: ProteinReference
xref: uniprot O08556 696
organism: Rattus norvegicus

Myosin-7
type: ProteinReference
xref: uniprot P12883 1320
xref: PTHR45615:SF1
organism: Homo sapiens

PKCzeta
type: Protein
entity reference: PKCzeta
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Myosin-1
type: ProteinReference
xref: PTHR45615:SF3
xref: uniprot P12882 1319
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3XYC6 930
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3XYC5 929
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3XYC8 932
organism: Branchiostoma floridae

UNKNOWN_TRANSITION
type: RelationshipTypeVocabulary

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3XYC7 931
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYC2 926
xref: PTHR11937:SF468
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3XYC4 928
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3XYC3 927
organism: Branchiostoma floridae

Cyclooxygenase
type: ProteinReference
xref: P00845
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.Cyclooxygenase
comment: ENTITY_REFERENCE_NOTES=Long Name: Cyclooxygenase Synonym: COX Accession: P00845
member entity reference: Cyclooxygenase 2
member entity reference: Prostaglandin G/H synthase 2
member entity reference: Prostaglandin G/H synthase 1
member entity reference: PTGS1 isoform 1

uniprot O96626 1598
type: UnificationXref
id: O96626
db: uniprot

uniprot F6U132 1569
type: UnificationXref
id: F6U132
db: uniprot

uniprot A0A3Q1NGS8 308
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

Actin, alpha 1, skeletal muscle
type: ProteinReference
xref: uniprot Q6DIV8 1063
xref: PTHR11937:SF193
organism: Xenopus tropicalis

G protein-coupled receptor kinase 2
type: ProteinReference
xref: PTHR24355:SF28
xref: uniprot P32866 460
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MP16 670
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P32871 1380
organism: Bos taurus

Complex (Galphai/q/ GTP)
type: Complex
component stoichiometry: GTP s22 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: Galphai q s21 sa16 STOICHIOMETRY ID COMPLEX
component: Galphai/q
component: GTP
feature: COMPLEX BINDING FEATURE s35 a60 1748
feature: COMPLEX BINDING FEATURE s35 a60 1750
cellular location: cytoplasm

Nuclear factor of activated T-cells, cytoplasmic 2
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot Q13469 624
organism: Homo sapiens

uniprot P46002 726
type: UnificationXref
id: P46002
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot A0A3Q1LSY0 382
organism: Bos taurus

Secretion of New Cytokines and Chemokines
type: Pathway

Rho-associated protein kinase 1
type: ProteinReference
xref: uniprot Q13464 1692
xref: PTHR22988:SF33
organism: Homo sapiens

uniprot P68133 1034
type: UnificationXref
id: P68133
db: uniprot

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 1056

uniprot F6T0T9 1146
type: UnificationXref
id: F6T0T9
db: uniprot

uniprot Q05513 124
type: UnificationXref
id: Q05513
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot C8V7D1 264
xref: PTHR24055:SF158
organism: Emericella nidulans

SHIP
type: ProteinReference
xref: P00839
standard name: SH2 domain-containing inositol 5-phosphatase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.SHIP
comment: ENTITY_REFERENCE_NOTES=Long Name: SH2 domain-containing inositol 5-phosphatase Synonym: SHIP Accession: P00839
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
member entity reference: Uncharacterized protein
member entity reference: Inositol polyphosphate phosphatase like 1
member entity reference: INPPL1 isoform 1

C-X-C chemokine receptor type 2
type: ProteinReference
xref: PTHR10489:SF689
xref: uniprot P35407 723
organism: Rattus norvegicus

uniprot P06244 1160
type: UnificationXref
id: P06244
db: uniprot

PARTICIPANT STOICHIOMETRY r18 1791
type: Stoichiometry
physical entity: PYK2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r18 1790
type: Stoichiometry
physical entity: PYK2
stoichiometric coefficient: 1.0

Myosin heavy chain 11
type: ProteinReference
xref: PTHR45615:SF23
xref: uniprot A0A2I3RHK4 1251
organism: Pan troglodytes

UNKNOWN_TRANSITION_LEFT__Complex__Galphai_q__GTP_-RIGHT__Complex__Galphai_GTP_-_r6
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 1793
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 1792
left: Complex (Galphai/q/ GTP)
interaction type: UNKNOWN_TRANSITION
right: Complex (Galphai/GTP)

CX3C chemokine receptor 1
type: ProteinReference
xref: PTHR10489:SF637
xref: uniprot P35411 724
organism: Rattus norvegicus

Actin-related protein 2/3 complex subunit 1
type: ProteinReference
xref: uniprot P78774 1607
xref: PTHR10709:SF2
organism: Schizosaccharomyces pombe

Uncharacterized protein
type: ProteinReference
xref: PTHR10663:SF343
xref: uniprot F7GGR0 1539
organism: Macaca mulatta

uniprot Q6Z3Y9 1513
type: UnificationXref
id: Q6Z3Y9
db: uniprot

uniprot F1PT97 1566
type: UnificationXref
id: F1PT97
db: uniprot

Actin 1
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q6TYS2 1069
organism: Physcomitrella patens

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 188

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF9
xref: uniprot F6SSS3 319
organism: Monodelphis domestica

uniprot P51432 1497
type: UnificationXref
id: P51432
db: uniprot

uniprot Q01341 476
type: UnificationXref
id: Q01341
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A8JAV1 905
organism: Chlamydomonas reinhardtii

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
type: ProteinReference
xref: uniprot Q8K4S1 1519
organism: Mus musculus

N-formyl peptide receptor 3
type: ProteinReference
xref: uniprot P25089 714
organism: Homo sapiens

uniprot P63310 1664
type: UnificationXref
id: P63310
db: uniprot

uniprot O97571 708
type: UnificationXref
id: O97571
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
type: ProteinReference
xref: uniprot G5EFI8 1472
organism: Caenorhabditis elegans

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: uniprot Q00722 1498
xref: PTHR10336:SF10
organism: Homo sapiens

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

uniprot F0Z6V2 1564
type: UnificationXref
id: F0Z6V2
db: uniprot

Raf-1
type: ProteinReference
xref: P00843
standard name: RAF proto-oncogene serine/threonine-protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.Raf-1
comment: ENTITY_REFERENCE_NOTES=Long Name: Raf-1 Synonym: v-raf-1 Accession: P00843
member entity reference: B-Raf proto-oncogene, serine/threonine kinase
member entity reference: Uncharacterized protein
member entity reference: RAF proto-oncogene serine/threonine-protein kinase
member entity reference: Raf-1 proto-oncogene, serine/threonine kinase
member entity reference: Serine/threonine-protein kinase A-Raf
member entity reference: Serine/threonine-protein kinase B-raf
member entity reference: Raf homolog serine/threonine-protein kinase Raf
member entity reference: A-Raf proto-oncogene, serine/threonine kinase

Arachidonate 12-lipoxygenase, 12S-type
type: ProteinReference
xref: PTHR11771:SF4
xref: uniprot P39655 140
organism: Mus musculus

Arachidonate 15-lipoxygenase
type: ProteinReference
xref: PTHR11771:SF33
xref: uniprot P39654 139
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYD4 934
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYD3 933
organism: Branchiostoma floridae

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P14056 528
organism: Rattus norvegicus

RGS13 isoform 1
type: ProteinReference
xref: PTHR10845:SF32
xref: uniprot A0A2J8N697 166
organism: Pan troglodytes

uniprot F7GET1 170
type: UnificationXref
id: F7GET1
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot Q9M1Z5 306
xref: PTHR24055:SF466
organism: Arabidopsis thaliana

uniprot A0A0G2K5T3 1355
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 889

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot F7BIC2 1131
xref: PTHR24356:SF159
organism: Macaca mulatta

uniprot Q3SYX9 1617
type: UnificationXref
id: Q3SYX9
db: uniprot

uniprot F6RFW8 962
type: UnificationXref
id: F6RFW8
db: uniprot

uniprot F6RIM7 88
type: UnificationXref
id: F6RIM7
db: uniprot

Phosphoinositide phospholipase C 4
type: ProteinReference
xref: uniprot Q944C1 1522
organism: Arabidopsis thaliana

uniprot A0A2I3TJW3 1645
type: UnificationXref
id: A0A2I3TJW3
db: uniprot

Arp2/3
type: Protein
entity reference: Arp2/3
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR45615:SF40
type: RelationshipXref
id: PTHR45615:SF40
db: PANTHER Family
relationship type: By Homology

PTHR45615:SF43
type: RelationshipXref
id: PTHR45615:SF43
db: PANTHER Family
relationship type: By Homology

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05126 1135
xref: PTHR24356:SF158
organism: Bos taurus

PTHR45615:SF44
type: RelationshipXref
id: PTHR45615:SF44
db: PANTHER Family
relationship type: By Homology

uniprot P10989 1001
type: UnificationXref
id: P10989
db: uniprot

Cell division control protein 42
type: ProteinReference
xref: uniprot Q9HF56 256
organism: Ashbya gossypii

Shc
type: Protein
entity reference: Shc
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot K7C9Z9 533
type: UnificationXref
id: K7C9Z9
db: uniprot

uniprot P13944 1213
type: UnificationXref
id: P13944
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot B2RSH2 86
organism: Mus musculus

Phospholipase A2
type: ProteinReference
evidence: Evidence 786
xref: PTHR10728:SF13
xref: uniprot F7EEZ1 790
organism: Macaca mulatta

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 799
xref: PTHR10728:SF13
xref: uniprot P50393 797
organism: Rattus norvegicus

PTHR45615:SF39
type: RelationshipXref
id: PTHR45615:SF39
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit alpha
type: ProteinReference
xref: uniprot Q00743 109
organism: Emericella nidulans

Cytosolic phospholipase A2
type: ProteinReference
xref: uniprot P50392 796
xref: PTHR10728:SF13
organism: Danio rerio

CaMK
type: Protein
entity reference: CaMK
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot E1BA03 388
type: UnificationXref
id: E1BA03
db: uniprot

uniprot D3ZFJ0 1358
type: UnificationXref
id: D3ZFJ0
db: uniprot

uniprot A3KGF7 1443
type: UnificationXref
id: A3KGF7
db: uniprot

Myosin-7
type: ProteinReference
xref: PTHR45615:SF1
xref: uniprot Q91Z83 1346
organism: Mus musculus

uniprot P68136 1036
type: UnificationXref
id: P68136
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P05132 1158
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P05131 1157
organism: Bos taurus

Galphai s18 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Galphai
stoichiometric coefficient: 1.0

uniprot A0A2I3S4I6 1116
type: UnificationXref
id: A0A2I3S4I6
db: uniprot

uniprot A2BGX6 1260
type: UnificationXref
id: A2BGX6
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot H2QKD0 1475
xref: PTHR10336:SF173
organism: Pan troglodytes

Phosphoinositide phospholipase C (Fragment)
type: ProteinReference
xref: uniprot Q7PW25 1514
organism: Anopheles gambiae

PTHR45615:SF48
type: RelationshipXref
id: PTHR45615:SF48
db: PANTHER Family
relationship type: By Homology

uniprot P30677 33
type: UnificationXref
id: P30677
db: uniprot

PTHR45615:SF23
type: RelationshipXref
id: PTHR45615:SF23
db: PANTHER Family
relationship type: By Homology

PTHR45615:SF24
type: RelationshipXref
id: PTHR45615:SF24
db: PANTHER Family
relationship type: By Homology

…
type: Stoichiometry
physical entity: Cytokine receptor
stoichiometric coefficient: 2.0

uniprot Q8K120 626
type: UnificationXref
id: Q8K120
db: uniprot

uniprot P23219 535
type: UnificationXref
id: P23219
db: uniprot

uniprot P39655 140
type: UnificationXref
id: P39655
db: uniprot

Nuclear factor NF-kappa-B p105 subunit
type: ProteinReference
xref: PTHR24169:SF9
xref: uniprot F1LQH2 1096
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot F5HMB9 1459
organism: Anopheles gambiae

uniprot P97305 622
type: UnificationXref
id: P97305
db: uniprot

PARTICIPANT STOICHIOMETRY r54 1906
type: Stoichiometry
physical entity: JAK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r54 1905
type: Stoichiometry
physical entity: JAK
stoichiometric coefficient: 1.0

uniprot Q62035 766
type: UnificationXref
id: Q62035
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot F1PJE5 317
organism: Canis lupus familiaris

uniprot F6Y841 1367
type: UnificationXref
id: F6Y841
db: uniprot

PTHR45615:SF16
type: RelationshipXref
id: PTHR45615:SF16
db: PANTHER Family
relationship type: By Homology

uniprot Q9JL25 178
type: UnificationXref
id: Q9JL25
db: uniprot

Myosin heavy chain 10
type: ProteinReference
xref: PTHR45615:SF24
xref: uniprot F1PVV7 1281
organism: Canis lupus familiaris

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot K7CDC2 64
xref: PTHR24356:SF176
organism: Pan troglodytes

PTHR45615:SF35
type: RelationshipXref
id: PTHR45615:SF35
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r24 1894
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 1895
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

C-C motif chemokine
type: ProteinReference
xref: uniprot A0A2J8PX74 802
xref: PTHR12015:SF73
organism: Pan troglodytes

PTHR45615:SF31
type: RelationshipXref
id: PTHR45615:SF31
db: PANTHER Family
relationship type: By Homology

Protein CBR-CDC-42
type: ProteinReference
xref: uniprot A8XGW3 181
organism: Caenorhabditis briggsae

Nuclear factor of activated T-cells, cytoplasmic 3 isoform 2
type: ProteinReference
xref: uniprot F6RNN7 614
xref: PTHR12533:SF6
organism: Macaca mulatta

uniprot P61072 747
type: UnificationXref
id: P61072
db: uniprot

Signal transducer and activator of transcription 3
type: ProteinReference
xref: uniprot P52631 160
xref: PTHR11801:SF2
organism: Rattus norvegicus

MLCK
type: ProteinReference
xref: P00877
standard name: Myosin light chain kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Myosin light chain kinase Synonym: Synonym not specified Accession: P00877
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.MLCK
member entity reference: Uncharacterized protein
member entity reference: Myosin Light Chain Kinase related
member entity reference: Myosin light chain kinase
member entity reference: Myosin light chain kinase 3
member entity reference: Myosin light chain kinase 2
member entity reference: Myosin light chain kinase 2, skeletal/cardiac muscle
member entity reference: Myosin light chain kinase, smooth muscle

Signal transducer and transcription activator 6
type: ProteinReference
xref: uniprot P52633 161
xref: PTHR11801:SF48
organism: Mus musculus

uniprot P08752 99
type: UnificationXref
id: P08752
db: uniprot

uniprot H2Q1R1 1305
type: UnificationXref
id: H2Q1R1
db: uniprot

uniprot Q9PTF7 778
type: UnificationXref
id: Q9PTF7
db: uniprot

uniprot P78556 856
type: UnificationXref
id: P78556
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot Q8MJ44 1184
organism: Canis lupus familiaris

uniprot Q17031 239
type: UnificationXref
id: Q17031
db: uniprot

CaMK
type: Protein
entity reference: CaMK
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P12883 1320
type: UnificationXref
id: P12883
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P78711 1039
organism: Neurospora crassa

PTHR45615:SF29
type: RelationshipXref
id: PTHR45615:SF29
db: PANTHER Family
relationship type: By Homology

PTHR45615:SF26
type: RelationshipXref
id: PTHR45615:SF26
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r86 1904
type: Stoichiometry
physical entity: Complex (Cytokine receptor/IL2)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r86 1902
type: Stoichiometry
physical entity: Cytokine receptor
stoichiometric coefficient: 1.0

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot O15357 453
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r86 1903
type: Stoichiometry
physical entity: IL2
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F7BYN4 155
xref: PTHR11801:SF2
organism: Monodelphis domestica

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF10
xref: uniprot E2RMT4 1563
organism: Canis lupus familiaris

JunB proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: PTHR11462:SF37
xref: uniprot J9NRZ4 436
organism: Canis lupus familiaris

Ras homolog gene family, member G (Rho G)
type: ProteinReference
xref: uniprot Q1RMI2 240
organism: Bos taurus

uniprot C3XYC7 931
type: UnificationXref
id: C3XYC7
db: uniprot

C-X-C chemokine receptor type 4
type: ProteinReference
xref: uniprot P25930 715
xref: PTHR10489:SF594
organism: Bos taurus

uniprot F7G1K7 21
type: UnificationXref
id: F7G1K7
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F1N7C3 596
organism: Bos taurus

C-X-C chemokine receptor type 1
type: ProteinReference
xref: PTHR10489:SF916
xref: uniprot P25024 712
organism: Homo sapiens

C-X-C chemokine receptor type 2
type: ProteinReference
xref: uniprot P25025 713
xref: PTHR10489:SF689
organism: Homo sapiens

Putative actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A0A0D1DMT3 886
organism: Ustilago maydis

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa3 1707
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Protein kinase C
type: ProteinReference
xref: uniprot F1MDC9 1129
xref: PTHR24351:SF182
organism: Bos taurus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 327
xref: PTHR13809:SF19
organism: Monodelphis domestica

Shc
type: Protein
entity reference: Shc
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa35 1743
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Plasma membrane phospholipid
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Inhibitor of nuclear factor kappa-B kinase subunit epsilon
type: ProteinReference
xref: uniprot Q9R0T8 1429
xref: PTHR22969:SF10
organism: Mus musculus

Actin-42A
type: ProteinReference
xref: uniprot P02572 989
xref: PTHR11937:SF453
organism: Drosophila melanogaster

ncbitaxon 9615 52
type: UnificationXref
id: 9615
db: ncbitaxon

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF1
xref: uniprot H2RBJ1 1583
organism: Pan troglodytes

uniprot F1Q3M8 1363
type: UnificationXref
id: F1Q3M8
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7FKL1 404
organism: Macaca mulatta

Actin, larval muscle
type: ProteinReference
xref: PTHR11937:SF397
xref: uniprot P02574 990
organism: Drosophila melanogaster

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PIP2-RIGHT__PIP3-_r28
controller: PI3K

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

PTHR10709:SF2
type: RelationshipXref
id: PTHR10709:SF2
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
evidence: Evidence 508
evidence: Evidence 507
evidence: Evidence 506
evidence: Evidence 509
xref: PTHR44329:SF22
xref: uniprot F7BRK5 516
organism: Monodelphis domestica

Guanine nucleotide-binding protein alpha subunit
type: ProteinReference
xref: uniprot A7F345 83
organism: Sclerotinia sclerotiorum

Uncharacterized protein rac1A
type: ProteinReference
xref: uniprot F1A084 198
organism: Dictyostelium purpureum

Protein CBR-ACT-5
type: ProteinReference
xref: PTHR11937:SF359
xref: uniprot A8XS95 909
organism: Caenorhabditis briggsae

STATE_TRANSITION_LEFT__MAPK-RIGHT__MAPK-_r77
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 1809
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 1808
left: MAPK
interaction type: STATE_TRANSITION
right: MAPK

uniprot Q9UKX2 1351
type: UnificationXref
id: Q9UKX2
db: uniprot

uniprot C8V7D1 264
type: UnificationXref
id: C8V7D1
db: uniprot

Mitogen-activated protein kinase (Fragment)
type: ProteinReference
xref: uniprot Q7PVR1 299
xref: PTHR24055:SF158
organism: Anopheles gambiae

Serine/threonine-protein kinase PAK 4
type: ProteinReference
xref: uniprot Q8BTW9 423
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot F6TFY2 320
organism: Macaca mulatta

Beta-actin-like protein 2
type: ProteinReference
xref: uniprot Q562R1 1053
xref: PTHR11937:SF168
organism: Homo sapiens

uniprot P32246 717
type: UnificationXref
id: P32246
db: uniprot

Phosphoinositide phospholipase C 7
type: ProteinReference
xref: uniprot Q9LY51 1526
organism: Arabidopsis thaliana

uniprot Q00168 572
type: UnificationXref
id: Q00168
db: uniprot

Actin-related protein 2/3 complex subunit 1A
type: ProteinReference
xref: uniprot Q9R0Q6 1636
xref: PTHR10709:SF11
organism: Mus musculus

C-C chemokine receptor type 4
type: ProteinReference
xref: uniprot F7GUA3 680
xref: PTHR10489:SF608
organism: Macaca mulatta

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot B1N2P0 920
organism: Entamoeba histolytica

uniprot Q8VCR8 1656
type: UnificationXref
id: Q8VCR8
db: uniprot

uniprot P33204 1600
type: UnificationXref
id: P33204
db: uniprot

PTHR24070:SF17
type: RelationshipXref
id: PTHR24070:SF17
db: PANTHER Family
relationship type: By Homology

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot Q9QY78 1428
xref: PTHR22969:SF7
organism: Rattus norvegicus

ncbitaxon 7668 1003
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot F7G800 405
type: UnificationXref
id: F7G800
db: uniprot

uniprot P49799 174
type: UnificationXref
id: P49799
db: uniprot

uniprot F7CQJ3 1574
type: UnificationXref
id: F7CQJ3
db: uniprot

uniprot H2R8L2 1233
type: UnificationXref
id: H2R8L2
db: uniprot

PARTICIPANT STOICHIOMETRY re67 1876
type: Stoichiometry
physical entity: IkappaB
stoichiometric coefficient: 1.0

PTHR11937:SF278
type: RelationshipXref
id: PTHR11937:SF278
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re67 1877
type: Stoichiometry
physical entity: NFkappaB
stoichiometric coefficient: 1.0

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 195

uniprot Q5A1D3 294
type: UnificationXref
id: Q5A1D3
db: uniprot

uniprot P0DM41 995
type: UnificationXref
id: P0DM41
db: uniprot

PARTICIPANT STOICHIOMETRY re67 1878
type: Stoichiometry
physical entity: Complex (NFkappaB/IkappaB)
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type 2
type: ProteinReference
xref: uniprot P06245 1161
xref: PTHR24353:SF117
organism: Saccharomyces cerevisiae

uniprot Q62915 578
type: UnificationXref
id: Q62915
db: uniprot

cAMP-dependent protein kinase type 1
type: ProteinReference
xref: PTHR24353:SF73
xref: uniprot P06244 1160
organism: Saccharomyces cerevisiae

uniprot B8A568 1267
type: UnificationXref
id: B8A568
db: uniprot

Interleukin-10 receptor subunit beta
type: ProteinReference
xref: uniprot Q61190 1244
xref: PTHR20859:SF50
organism: Mus musculus

uniprot Q9JLY0 1688
type: UnificationXref
id: Q9JLY0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF3
xref: uniprot H2QCA0 1309
organism: Pan troglodytes

uniprot Q9XWV3 1643
type: UnificationXref
id: Q9XWV3
db: uniprot

INFgamma
type: Protein
entity reference: INFgamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s79 sa30 1701
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q9D898 1634
type: UnificationXref
id: Q9D898
db: uniprot

PTHR11937:SF248
type: RelationshipXref
id: PTHR11937:SF248
db: PANTHER Family
relationship type: By Homology

uniprot P68404 1138
type: UnificationXref
id: P68404
db: uniprot

uniprot P51680 737
type: UnificationXref
id: P51680
db: uniprot

uniprot Q9NQ66 1527
type: UnificationXref
id: Q9NQ66
db: uniprot

PTHR11937:SF240
type: RelationshipXref
id: PTHR11937:SF240
db: PANTHER Family
relationship type: By Homology

uniprot O14544 1682
type: UnificationXref
id: O14544
db: uniprot

uniprot C4M5Q7 190
type: UnificationXref
id: C4M5Q7
db: uniprot

uniprot P17325 443
type: UnificationXref
id: P17325
db: uniprot

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot Q1ECJ7 1613
organism: Arabidopsis thaliana

Adenylate cyclase
type: ProteinReference
xref: uniprot F6V001 468
xref: PTHR45627:SF6
organism: Monodelphis domestica

G protein subunit alpha 14
type: ProteinReference
xref: uniprot Q5EAP4 40
organism: Rattus norvegicus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot A0A0G2K344 1354
xref: PTHR10048:SF107
organism: Rattus norvegicus

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: uniprot Q7T3D3 116
organism: Danio rerio

uniprot O88656 1593
type: UnificationXref
id: O88656
db: uniprot

Actin-related protein 2/3 complex subunit 5-like protein
type: ProteinReference
xref: uniprot A1L108 1552
organism: Rattus norvegicus

uniprot P24063 652
type: UnificationXref
id: P24063
db: uniprot

uniprot P29995 498
type: UnificationXref
id: P29995
db: uniprot

uniprot H2R9J3 1311
type: UnificationXref
id: H2R9J3
db: uniprot

uniprot P15261 1240
type: UnificationXref
id: P15261
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
type: ProteinReference
xref: uniprot Q6P549 454
xref: PTHR46051:SF2
organism: Mus musculus

uniprot E2RJA0 394
type: UnificationXref
id: E2RJA0
db: uniprot

CHKR
type: ProteinReference
xref: P00854
standard name: Chemokine receptor
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.RECEPTOR.CHKR
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: C-C chemokine receptor type 6
member entity reference: C-C chemokine receptor type 5
member entity reference: Uncharacterized protein
member entity reference: C-X-C chemokine receptor type 1
member entity reference: N-formyl peptide receptor 3 (Fragment)
member entity reference: Platelet-activating factor receptor
member entity reference: Leukotriene B4 receptor 2
member entity reference: C-C chemokine receptor type 10
member entity reference: C-C chemokine receptor type 8
member entity reference: C-X-C chemokine receptor type 3
member entity reference: C-C chemokine receptor type 2
member entity reference: CX3C chemokine receptor 1
member entity reference: C-X-C chemokine receptor type 2 (Fragment)
member entity reference: C-C chemokine receptor type 4
member entity reference: C-X3-C motif chemokine receptor 1
member entity reference: Formyl peptide receptor-related sequence 6
member entity reference: C-X-C chemokine receptor type 4
member entity reference: C-C motif chemokine receptor 9
member entity reference: Chemokine XC receptor 1
member entity reference: C-C chemokine receptor 1-like protein 1
member entity reference: C-X-C chemokine receptor type 2
member entity reference: C-C motif chemokine receptor 3
member entity reference: C-C motif chemokine receptor 7
member entity reference: fMet-Leu-Phe receptor
member entity reference: C-C chemokine receptor type 1
member entity reference: Formyl peptide receptor-related sequence 7
member entity reference: C-C chemokine receptor type 3
member entity reference: C5a anaphylatoxin chemotactic receptor 1
member entity reference: Formyl peptide receptor,-related sequence 3
member entity reference: Chemokine (C-X-C motif), receptor 4b
member entity reference: C-C chemokine receptor-like 2
member entity reference: C3a anaphylatoxin chemotactic receptor
member entity reference: CCR4 protein
member entity reference: C-C motif chemokine receptor 4
member entity reference: fMet-Leu-Phe receptor (Fragment)
member entity reference: Formyl peptide receptor,-related sequence 4
member entity reference: C-C motif chemokine receptor like 2
member entity reference: Chemokine (C-X-C motif) receptor 4a
member entity reference: C-C chemokine receptor type 9
member entity reference: N-formyl peptide receptor 3
member entity reference: C-C motif chemokine receptor 8
member entity reference: C-X-C chemokine receptor type 6
member entity reference: Formyl peptide receptor-related sequence 1
member entity reference: C-C motif chemokine receptor 2
member entity reference: C-C motif chemokine receptor 10

uniprot P13500 837
type: UnificationXref
id: P13500
db: uniprot

uniprot H2QW34 1421
type: UnificationXref
id: H2QW34
db: uniprot

C-X-C motif chemokine 10
type: ProteinReference
xref: PTHR10179:SF47
xref: uniprot P17515 842
organism: Mus musculus

uniprot F7BYI4 1132
type: UnificationXref
id: F7BYI4
db: uniprot

uniprot C3XYD4 934
type: UnificationXref
id: C3XYD4
db: uniprot

Interleukin-8
type: ProteinReference
xref: PTHR10179:SF42
xref: uniprot P67813 854
organism: Macaca mulatta

uniprot Q62711 1512
type: UnificationXref
id: Q62711
db: uniprot

C-X-C chemokine receptor type 2
type: ProteinReference
xref: PTHR10489:SF689
xref: uniprot O97571 708
organism: Canis lupus familiaris

uniprot Q6DIV8 1063
type: UnificationXref
id: Q6DIV8
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot Q14573 501
xref: PTHR13715:SF51
organism: Homo sapiens

uniprot Q8WXH5 1687
type: UnificationXref
id: Q8WXH5
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot Q14571 500
xref: PTHR13715:SF53
organism: Homo sapiens

C-X-C motif chemokine 10
type: ProteinReference
xref: PTHR10179:SF47
xref: uniprot Q8MIZ1 872
organism: Macaca mulatta

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot P35465 412
organism: Rattus norvegicus

uniprot P84096 232
type: UnificationXref
id: P84096
db: uniprot

Arp2/3
type: ProteinReference
xref: P00876
standard name: Actin related protein 2/3 complex
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Actin related protein 2/3 complex Synonym: Synonym not specified Accession: P00876
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.Arp2/3
member entity reference: Actin-related protein 2/3 complex subunit 1B
member entity reference: Actin-related protein 2/3 complex subunit 5
member entity reference: Actin-related protein 2/3 complex subunit 5-like protein
member entity reference: Actin-related protein 2/3 complex subunit 4
member entity reference: Actin-related protein 2/3 complex subunit
member entity reference: Actin-related protein 2/3 complex subunit 1A
member entity reference: Actin-related protein 2/3 complex subunit 3
member entity reference: Actin-related protein 2/3 complex subunit 2
member entity reference: Arp2/3 complex 34 kDa subunit
member entity reference: Probable actin-related protein 2/3 complex subunit 4
member entity reference: Probable actin-related protein 2/3 complex subunit 5
member entity reference: Actin-related protein 2/3 complex subunit 1
member entity reference: Probable actin-related protein 2/3 complex subunit 3
member entity reference: Uncharacterized protein (Fragment)

uniprot W4XTP5 1088
type: UnificationXref
id: W4XTP5
db: uniprot

Myosin-6
type: ProteinReference
xref: PTHR45615:SF11
xref: uniprot P02563 1313
organism: Rattus norvegicus

Myosin-7
type: ProteinReference
xref: uniprot P02564 1314
xref: PTHR45615:SF1
organism: Rattus norvegicus

Myosin-1B
type: ProteinReference
xref: uniprot P02565 1315
xref: PTHR45615:SF48
organism: Gallus gallus

uniprot F1P476 954
type: UnificationXref
id: F1P476
db: uniprot

uniprot A8XJQ6 1143
type: UnificationXref
id: A8XJQ6
db: uniprot

Myosin-10
type: ProteinReference
xref: PTHR45615:SF24
xref: uniprot Q61879 1337
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: uniprot F7BYI4 1132
xref: PTHR24356:SF158
organism: Macaca mulatta

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

TRANSPORT_LEFT__NFkappaB-RIGHT__NFkappaB-_r48
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1800
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1801
left: NFkappaB
interaction type: TRANSPORT
right: NFkappaB

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot H2QJY5 1474
organism: Pan troglodytes

JUNB isoform 1
type: ProteinReference
xref: uniprot H2R6C6 435
xref: PTHR11462:SF37
organism: Pan troglodytes

uniprot Q7PW25 1514
type: UnificationXref
id: Q7PW25
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot D3ZFJ0 1358
organism: Rattus norvegicus

uniprot F6VBA7 590
type: UnificationXref
id: F6VBA7
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot Q9NQ66 1527
organism: Homo sapiens

Transcription factor jun-D
type: ProteinReference
xref: uniprot P17535 444
xref: PTHR11462:SF7
organism: Homo sapiens

Actin, muscle
type: ProteinReference
xref: PTHR11937:SF359
xref: uniprot W4XTP5 1088
organism: Strongylocentrotus purpuratus

C-C motif chemokine 7
type: ProteinReference
xref: uniprot Q9QXY8 878
organism: Rattus norvegicus

Interleukin-6
type: ProteinReference
xref: uniprot P08505 1409
organism: Mus musculus

C-C motif chemokine 4
type: ProteinReference
xref: uniprot P14097 839
xref: PTHR12015:SF103
organism: Mus musculus

uniprot H2QKD0 1475
type: UnificationXref
id: H2QKD0
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P62999 228
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: uniprot P82471 1430
organism: Rattus norvegicus

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot A8XRA5 1445
organism: Caenorhabditis briggsae

uniprot P53494 1010
type: UnificationXref
id: P53494
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot E1BH60 1447
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r9 1784
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

JAK
type: Protein
entity reference: JAK
feature: COMPLEX PARTICIPANT BINDING FEATURE s70 sa27 1697
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Inactive phospholipase C-like protein 1
type: ProteinReference
xref: uniprot Q62688 1511
organism: Rattus norvegicus

Tyrosine-protein kinase JAK2
type: ProteinReference
xref: PTHR45807:SF1
xref: uniprot Q62689 549
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__Arachidonic_acid-RIGHT__Leukotriene-_r82
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 1915
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 1914
left: Arachidonic acid
interaction type: STATE_TRANSITION
right: Leukotriene

C-C motif chemokine receptor 7
type: ProteinReference
xref: PTHR10489:SF635
xref: uniprot Q6U2D6 767
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r9 1785
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

PTHR45816:SF3
type: RelationshipXref
id: PTHR45816:SF3
db: PANTHER Family
relationship type: By Homology

STAT
type: Protein
entity reference: STAT
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot H3F5B4 984
type: UnificationXref
id: H3F5B4
db: uniprot

uniprot B2RSH2 86
type: UnificationXref
id: B2RSH2
db: uniprot

uniprot E3K4I1 945
type: UnificationXref
id: E3K4I1
db: uniprot

PARTICIPANT STOICHIOMETRY r11 1819
type: Stoichiometry
physical entity: SrcPTK
stoichiometric coefficient: 1.0

uniprot P49134 655
type: UnificationXref
id: P49134
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot A0A3Q1MMD9 1441
organism: Bos taurus

Actin A
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q38E94 1047
organism: Trypanosoma brucei

uniprot P51178 1496
type: UnificationXref
id: P51178
db: uniprot

CASK isoform 4
type: ProteinReference
xref: PTHR23122:SF40
xref: uniprot H2R4R8 564
organism: Pan troglodytes

uniprot H2Q7D6 130
type: UnificationXref
id: H2Q7D6
db: uniprot

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot P60766 225
organism: Mus musculus

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: PTHR12644:SF1
xref: uniprot Q9CPW4 1632
organism: Mus musculus

uniprot F7EPQ4 128
type: UnificationXref
id: F7EPQ4
db: uniprot

SHC-transforming protein 1
type: ProteinReference
xref: uniprot Q5M824 1237
xref: PTHR10337:SF2
organism: Rattus norvegicus

uniprot Q5KP84 1177
type: UnificationXref
id: Q5KP84
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot H2QLZ4 493
xref: PTHR13715:SF53
organism: Pan troglodytes

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot H2QSU0 494
xref: PTHR13715:SF51
organism: Pan troglodytes

uniprot Q8QG55 874
type: UnificationXref
id: Q8QG55
db: uniprot

PARTICIPANT STOICHIOMETRY r11 1820
type: Stoichiometry
physical entity: SrcPTK
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot Q61011 371
organism: Mus musculus

uniprot P27870 1543
type: UnificationXref
id: P27870
db: uniprot

uniprot P52633 161
type: UnificationXref
id: P52633
db: uniprot

STATE_TRANSITION_LEFT__ROCK-RIGHT__ROCK-_r35
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 1845
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 1844
left: ROCK
interaction type: STATE_TRANSITION
right: ROCK

uniprot C3XYC5 929
type: UnificationXref
id: C3XYC5
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot Q63269 503
xref: PTHR13715:SF51
organism: Rattus norvegicus

PTHR11771:SF4
type: RelationshipXref
id: PTHR11771:SF4
db: PANTHER Family
relationship type: By Homology

C-X-C chemokine receptor type 5
type: ProteinReference
xref: uniprot P34997 721
xref: PTHR10489:SF618
organism: Rattus norvegicus

C-C motif chemokine receptor 9
type: ProteinReference
xref: PTHR10489:SF664
xref: uniprot A0A2I3TX94 660
organism: Pan troglodytes

uniprot A8XTZ1 1446
type: UnificationXref
id: A8XTZ1
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha 14
type: ProteinReference
xref: uniprot Q66JF0 44
organism: Xenopus tropicalis

C-C motif chemokine 4 homolog
type: ProteinReference
xref: uniprot Q90826 876
organism: Gallus gallus

HETERODIMER_ASSOCIATION_LEFT__Complex__Cytokine_receptor_JAK__JAK_INFgamma_-_STAT-RIGHT__Complex__Cytokine_receptor_JAK__JAK_STAT__INFgamma_-_r60
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 1865
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 1867
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 1866
left: STAT
left: Complex (Cytokine receptor/JAK/ JAK/INFgamma)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Cytokine receptor/JAK/ JAK/STAT/ INFgamma)

uniprot P10984 998
type: UnificationXref
id: P10984
db: uniprot

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 1079

Complex (Cytokine receptor/INFgamma)
type: Complex
component stoichiometry: INFgamma s31 sa21 STOICHIOMETRY ID COMPLEX
component: Cytokine receptor
component: INFgamma
feature: COMPLEX BINDING FEATURE s109 a159 1758
feature: COMPLEX BINDING FEATURE s109 a159 1756
cellular location: cytoplasm

uniprot A0A2I3SWV7 1533
type: UnificationXref
id: A0A2I3SWV7
db: uniprot

uniprot F1A084 198
type: UnificationXref
id: F1A084
db: uniprot

uniprot H2QJP2 1205
type: UnificationXref
id: H2QJP2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 372
xref: PTHR13809:SF8
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y1Q0 808
organism: Macaca mulatta

Actin alpha 1, skeletal muscle a
type: ProteinReference
xref: uniprot F1QUN8 955
xref: PTHR11937:SF416
organism: Danio rerio

Cell division control protein 42
type: ProteinReference
xref: uniprot P19073 214
organism: Saccharomyces cerevisiae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PAK-RIGHT__PAK-_r36
controller: Rac

uniprot F7BRK5 516
type: UnificationXref
id: F7BRK5
db: uniprot

uniprot P51686 743
type: UnificationXref
id: P51686
db: uniprot

SHIP
type: Protein
entity reference: SHIP
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

eco ECO:0000245 519
type: UnificationXref
id: ECO:0000245
db: eco

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
type: ProteinReference
xref: PTHR22829:SF6
xref: uniprot Q8TCU6 1547
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZCW7 491
xref: PTHR13715:SF53
organism: Monodelphis domestica

uniprot F1PXS7 267
type: UnificationXref
id: F1PXS7
db: uniprot

SHC-transforming protein 1
type: ProteinReference
xref: uniprot P29353 1234
xref: PTHR10337:SF2
organism: Homo sapiens

STATE_TRANSITION_LEFT__PIP3-RIGHT__PIP2-_re73
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re73 1849
participant stoichiometry: PARTICIPANT STOICHIOMETRY re73 1848
left: PIP3
interaction type: STATE_TRANSITION
right: PIP2

PLCbetagamma
type: Protein
entity reference: PLCbetagamma
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF0
xref: uniprot F6U132 1569
organism: Monodelphis domestica

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot Q5R1X3 1058
organism: Pan troglodytes

uniprot F7CBU9 789
type: UnificationXref
id: F7CBU9
db: uniprot

uniprot H2QV00 1580
type: UnificationXref
id: H2QV00
db: uniprot

uniprot F7CTP1 330
type: UnificationXref
id: F7CTP1
db: uniprot

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot O15145 1589
xref: PTHR12391:SF1
organism: Homo sapiens

fMet-Leu-Phe receptor
type: ProteinReference
xref: PTHR24225:SF15
xref: uniprot P21462 710
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR24020:SF39
xref: uniprot F1NAB9 1198
organism: Gallus gallus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A2I3TQ88 152
xref: PTHR11801:SF2
organism: Pan troglodytes

uniprot H2QJE0 685
type: UnificationXref
id: H2QJE0
db: uniprot

uniprot Q62159 1125
type: UnificationXref
id: Q62159
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F1PL99 1455
organism: Canis lupus familiaris

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: uniprot O15143 1587
xref: PTHR10709:SF10
organism: Homo sapiens

uniprot Q7PVR1 299
type: UnificationXref
id: Q7PVR1
db: uniprot

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: PTHR12058:SF0
xref: uniprot O15144 1588
organism: Homo sapiens

uniprot B2RZ72 1559
type: UnificationXref
id: B2RZ72
db: uniprot

PARTICIPANT STOICHIOMETRY r46 1807
type: Stoichiometry
physical entity: IkappaB
stoichiometric coefficient: 1.0

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot F6PVY4 1567
organism: Macaca mulatta

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9LQQ9 305
xref: PTHR24055:SF438
organism: Arabidopsis thaliana

Chemokine XC receptor 1
type: ProteinReference
xref: uniprot Q9R0M1 779
organism: Mus musculus

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot Q8CFN2 253
xref: PTHR24072:SF136
organism: Rattus norvegicus

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot Q1RMJ6 1124
organism: Bos taurus

C-X-C chemokine receptor type 4
type: ProteinReference
xref: uniprot P61072 747
xref: PTHR10489:SF594
organism: Pan troglodytes

uniprot P17515 842
type: UnificationXref
id: P17515
db: uniprot

PARTICIPANT STOICHIOMETRY r46 1806
type: Stoichiometry
physical entity: IkappaB
stoichiometric coefficient: 1.0

PLCbetagamma
type: Protein
entity reference: PLCbetagamma
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

C-X-C chemokine receptor type 4
type: ProteinReference
xref: uniprot P61073 748
xref: PTHR10489:SF594
organism: Homo sapiens

pro-inflammatory anti-apoptotic genes
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

uniprot Q99JE6 1523
type: UnificationXref
id: Q99JE6
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F1PL90 1454
xref: PTHR10336:SF12
organism: Canis lupus familiaris

uniprot B3RKR4 921
type: UnificationXref
id: B3RKR4
db: uniprot

EMC
type: Protein
entity reference: EMC
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa19 1735
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot O08790 698
type: UnificationXref
id: O08790
db: uniprot

uniprot Q8CIH5 1516
type: UnificationXref
id: Q8CIH5
db: uniprot

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot Q61036 419
organism: Mus musculus

uniprot Q9PSX7 1126
type: UnificationXref
id: Q9PSX7
db: uniprot

Non-receptor tyrosine-protein kinase TYK2
type: ProteinReference
xref: PTHR45807:SF6
xref: uniprot Q9R117 550
organism: Mus musculus

uniprot Q9LQQ9 305
type: UnificationXref
id: Q9LQQ9
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A2I3T7A8 1356
organism: Pan troglodytes

Suppressor of cytokine signaling 4
type: ProteinReference
xref: PTHR10155:SF21
xref: uniprot Q8WXH5 1687
organism: Homo sapiens

uniprot Q14289 633
type: UnificationXref
id: Q14289
db: uniprot

Eotaxin
type: ProteinReference
xref: uniprot P97545 862
organism: Rattus norvegicus

uniprot P51679 736
type: UnificationXref
id: P51679
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12533:SF11
xref: uniprot A0A1D5RJQ0 605
organism: Macaca mulatta

TRANSCRIPTION_LEFT__Pro_inflammatory_genes-RIGHT__pro_inflammatory_genes-_re72
type: TemplateReaction
product: pro-inflammatory genes
xref: TRANSCRIPTION
participant: pro-inflammatory genes
participant: Pro-inflammatory genes
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot Q7PZC6 1182
type: UnificationXref
id: Q7PZC6
db: uniprot

INFgamma s31 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: INFgamma
stoichiometric coefficient: 1.0

uniprot P61585 1122
type: UnificationXref
id: P61585
db: uniprot

Integrin beta
type: ProteinReference
xref: uniprot A0A2I3SCU5 636
xref: PTHR10082:SF36
organism: Pan troglodytes

Formyl peptide receptor 2
type: ProteinReference
xref: uniprot O88536 706
organism: Mus musculus

STATE_TRANSITION_LEFT__AC-RIGHT__AC-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 1787
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 1786
left: AC
interaction type: STATE_TRANSITION
right: AC

Formyl peptide receptor-related sequence 3
type: ProteinReference
xref: uniprot O88537 707
organism: Mus musculus

uniprot P63260 1024
type: UnificationXref
id: P63260
db: uniprot

uniprot F6SFG7 1398
type: UnificationXref
id: F6SFG7
db: uniprot

RGS
type: ProteinReference
xref: P00833
standard name: Regulator of G-protein signaling
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.RGS
comment: ENTITY_REFERENCE_NOTES=Long Name: Regulator of G-protein Signaling Synonym: Synonym not specified Accession: P00833
member entity reference: Regulator of G-protein signaling 18
member entity reference: Regulator of G-protein signaling 1
member entity reference: Regulator of G-protein signaling 17
member entity reference: Regulator of G-protein signaling 14
member entity reference: Regulator of G-protein signaling 13
member entity reference: Regulator of G-protein signaling 17 (Predicted), isoform CRA_a
member entity reference: Regulator of G-protein signaling 4
member entity reference: Uncharacterized protein
member entity reference: RGS13 isoform 1

uniprot Q9JLY8 776
type: UnificationXref
id: Q9JLY8
db: uniprot

uniprot Q28824 1654
type: UnificationXref
id: Q28824
db: uniprot

uniprot A7S0V7 899
type: UnificationXref
id: A7S0V7
db: uniprot

uniprot A7F3M0 263
type: UnificationXref
id: A7F3M0
db: uniprot

Ras homolog family member G
type: ProteinReference
xref: uniprot Q32PX6 243
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IGZ2 310
xref: PTHR13809:SF11
organism: Xenopus tropicalis

ncbitaxon 45351 898
type: UnificationXref
id: 45351
db: ncbitaxon

C-C motif chemokine receptor 4
type: ProteinReference
xref: PTHR10489:SF608
xref: uniprot H2QM91 686
organism: Pan troglodytes

uniprot Q6DHS1 1062
type: UnificationXref
id: Q6DHS1
db: uniprot

Myosin-10
type: ProteinReference
xref: PTHR45615:SF24
xref: uniprot Q27991 1333
organism: Bos taurus

ncbitaxon 5759 191
type: UnificationXref
id: 5759
db: ncbitaxon

C-C motif chemokine receptor 10
type: ProteinReference
xref: uniprot H2QD32 684
xref: PTHR10489:SF773
organism: Pan troglodytes

uniprot F6YZA3 327
type: UnificationXref
id: F6YZA3
db: uniprot

Suppressor of cytokine-signaling 5
type: ProteinReference
xref: uniprot F1MWV6 1672
xref: PTHR10155:SF15
organism: Bos taurus

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot E2RMC0 485
xref: PTHR13715:SF51
organism: Canis lupus familiaris

uniprot P79240 753
type: UnificationXref
id: P79240
db: uniprot

uniprot H2R1G3 1153
type: UnificationXref
id: H2R1G3
db: uniprot

C-X-C chemokine receptor type 6
type: ProteinReference
xref: uniprot Q9TV16 780
xref: PTHR10489:SF705
organism: Pan troglodytes

uniprot P42225 158
type: UnificationXref
id: P42225
db: uniprot

uniprot Q8SPQ9 540
type: UnificationXref
id: Q8SPQ9
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot A0A3Q1N7P8 482
xref: PTHR45816:SF3
organism: Bos taurus

uniprot Q7PXF7 1181
type: UnificationXref
id: Q7PXF7
db: uniprot

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P31751 67
organism: Homo sapiens

uniprot P68033 1031
type: UnificationXref
id: P68033
db: uniprot

Integrin beta-1
type: ProteinReference
xref: uniprot P49134 655
xref: PTHR10082:SF28
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r75
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 1817
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 1818
left: Raf-1
interaction type: STATE_TRANSITION
right: Raf-1

uniprot F7EU36 976
type: UnificationXref
id: F7EU36
db: uniprot

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31750 66
organism: Mus musculus

uniprot A7F7Z6 180
type: UnificationXref
id: A7F7Z6
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1N8W8 396
xref: PTHR48015:SF30
organism: Gallus gallus

Bos taurus
type: BioSource
xref: ncbitaxon 9913 14

C-C chemokine receptor type 7
type: ProteinReference
xref: PTHR10489:SF635
xref: uniprot P47774 729
organism: Mus musculus

C-C motif chemokine
type: ProteinReference
xref: uniprot F6Y1K4 807
organism: Macaca mulatta

MYH10 isoform 1
type: ProteinReference
xref: PTHR45615:SF24
xref: uniprot A0A2I3RXX2 1253
organism: Pan troglodytes

uniprot Q06332 1412
type: UnificationXref
id: Q06332
db: uniprot

uniprot A0A0D1DSN6 1141
type: UnificationXref
id: A0A0D1DSN6
db: uniprot

uniprot A0A1D5NUC4 1227
type: UnificationXref
id: A0A1D5NUC4
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q3W7 341
xref: PTHR13809:SF11
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF359
xref: uniprot H3F5B4 984
organism: Pristionchus pacificus

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 798

uniprot P13236 836
type: UnificationXref
id: P13236
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
type: ProteinReference
xref: uniprot P10895 1489
organism: Bos taurus

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31749 65
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot P10894 1488
xref: PTHR10336:SF12
organism: Bos taurus

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q7YTV5 1074
organism: Trichoplax adhaerens

PARTICIPANT STOICHIOMETRY r51 1913
type: Stoichiometry
physical entity: NFAT
stoichiometric coefficient: 1.0

IkappaB
type: Protein
entity reference: IkappaB
feature: IkappaB s108 sa50 rs1
feature: IkappaB s108 sa50 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s108 sa50 1763
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot C3XZ13 935
type: UnificationXref
id: C3XZ13
db: uniprot

PARTICIPANT STOICHIOMETRY r51 1912
type: Stoichiometry
physical entity: NFAT
stoichiometric coefficient: 1.0

uniprot F1NGS8 557
type: UnificationXref
id: F1NGS8
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P30671 350
xref: PTHR13809:SF8
organism: Bos taurus

uniprot P17275 442
type: UnificationXref
id: P17275
db: uniprot

Cytosolic phospholipase A2
type: ProteinReference
xref: PTHR10728:SF13
xref: uniprot P49147 795
organism: Gallus gallus

C-C motif chemokine
type: ProteinReference
xref: uniprot F6Y1J3 806
organism: Macaca mulatta

uniprot B6RK61 1265
type: UnificationXref
id: B6RK61
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: uniprot P08487 1484
xref: PTHR10336:SF173
organism: Bos taurus

uniprot Q70UZ7 1221
type: UnificationXref
id: Q70UZ7
db: uniprot

uniprot A0A3Q1NH21 48
type: UnificationXref
id: A0A3Q1NH21
db: uniprot

uniprot A0A3Q1LVZ9 1257
type: UnificationXref
id: A0A3Q1LVZ9
db: uniprot

uniprot Q7Q3T7 1183
type: UnificationXref
id: Q7Q3T7
db: uniprot

Platelet-activating factor receptor
type: ProteinReference
xref: PTHR24233:SF6
xref: uniprot P46002 726
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6TWF0 398
organism: Macaca mulatta

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7G7I9 335
xref: PTHR13809:SF11
organism: Ornithorhynchus anatinus

uniprot Q99715 1224
type: UnificationXref
id: Q99715
db: uniprot

RELB proto-oncogene, NF-kB subunit
type: ProteinReference
xref: uniprot A0A2I3TGI5 1093
organism: Pan troglodytes

RAC serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q8INB9 75
xref: PTHR24356:SF333
organism: Drosophila melanogaster

uniprot P56484 746
type: UnificationXref
id: P56484
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HFU0 681
organism: Macaca mulatta

uniprot F7G1U7 22
type: UnificationXref
id: F7G1U7
db: uniprot

Actin, gamma
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P20359 1004
organism: Emericella nidulans

uniprot P15989 1215
type: UnificationXref
id: P15989
db: uniprot

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: uniprot P30677 33
organism: Mus musculus

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 42

Guanine nucleotide-binding protein subunit alpha-15
type: ProteinReference
xref: uniprot P30678 34
xref: PTHR10218:SF217
organism: Mus musculus

uniprot Q62077 1510
type: UnificationXref
id: Q62077
db: uniprot

Guanine nucleotide-binding protein subunit alpha-15
type: ProteinReference
xref: uniprot P30679 35
xref: PTHR10218:SF217
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF23
xref: uniprot F7FAW0 1299
organism: Monodelphis domestica

C-C motif chemokine
type: ProteinReference
xref: uniprot H2QCN5 811
organism: Pan troglodytes

uniprot Q7ZVF9 1075
type: UnificationXref
id: Q7ZVF9
db: uniprot

uniprot D4ADE0 667
type: UnificationXref
id: D4ADE0
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF1
xref: uniprot F7GT47 546
organism: Macaca mulatta

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A2J8MSR9 381
organism: Pan troglodytes

Gbetagamma
type: Protein
entity reference: Gbetagamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa4 1709
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Pro_inflammatory_anti_apoptotic_genes-RIGHT__pro_inflammatory_anti_apoptotic_genes-_re71
control type: ACTIVATION
controller: NFAT

Inositol 1,4,5-trisphosphate receptor type 1 isoform 3
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot H9FU38 495
organism: Macaca mulatta

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot H9FU32 517
organism: Macaca mulatta

uniprot P20689 1651
type: UnificationXref
id: P20689
db: uniprot

C-C motif chemokine 3
type: ProteinReference
xref: uniprot P10855 835
xref: PTHR12015:SF82
organism: Mus musculus

uniprot F1MYM3 1362
type: UnificationXref
id: F1MYM3
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot E3K4I1 945
organism: Puccinia graminis

uniprot H2QCN5 811
type: UnificationXref
id: H2QCN5
db: uniprot

uniprot Q4KLF8 1619
type: UnificationXref
id: Q4KLF8
db: uniprot

uniprot P78423 855
type: UnificationXref
id: P78423
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F1PLB3 1456
xref: PTHR10336:SF106
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit gamma-1
type: ProteinReference
xref: PTHR13809:SF48
xref: uniprot P38040 351
organism: Drosophila melanogaster

uniprot Q5KP06 1055
type: UnificationXref
id: Q5KP06
db: uniprot

Arp2/3
type: Protein
entity reference: Arp2/3
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P62999 228
type: UnificationXref
id: P62999
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3Z4K3 939
organism: Branchiostoma floridae

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
type: ProteinReference
xref: uniprot P51178 1496
organism: Homo sapiens

uniprot K7BA21 1481
type: UnificationXref
id: K7BA21
db: uniprot

uniprot H2R2S1 818
type: UnificationXref
id: H2R2S1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_r29
controller: PIP3

uniprot F1MDC9 1129
type: UnificationXref
id: F1MDC9
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F6WH53 545
xref: PTHR45807:SF1
organism: Monodelphis domestica

uniprot E2RGT8 1536
type: UnificationXref
id: E2RGT8
db: uniprot

Galphai q s3 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Galphai/q
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r48 1801
type: Stoichiometry
physical entity: NFkappaB
stoichiometric coefficient: 1.0

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot Q9VX82 1641
xref: PTHR12391:SF0
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r48 1800
type: Stoichiometry
physical entity: NFkappaB
stoichiometric coefficient: 1.0

Calcium/calmodulin dependent protein kinase II delta
type: ProteinReference
xref: uniprot A0A2I3TH19 553
xref: PTHR24347:SF365
organism: Pan troglodytes

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9V489 918
organism: Monosiga brevicollis

uniprot F6SRP9 1461
type: UnificationXref
id: F6SRP9
db: uniprot

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: uniprot O14241 1586
organism: Schizosaccharomyces pombe

Actin, alpha cardiac muscle 2
type: ProteinReference
xref: PTHR11937:SF416
xref: uniprot P20399 1005
organism: Xenopus tropicalis

ncbitaxon 7739 188
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot A0A2I3TH19 553
type: UnificationXref
id: A0A2I3TH19
db: uniprot

Jun proto-oncogene
type: ProteinReference
xref: uniprot F6RYL1 432
xref: PTHR11462:SF8
organism: Xenopus tropicalis

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot E1BQN6 120
organism: Gallus gallus

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot P60710 1016
organism: Mus musculus

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot P60711 1017
organism: Rattus norvegicus

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot P60712 1018
xref: PTHR11937:SF192
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SrcPTK-RIGHT__SrcPTK-_r11
controller: Complex (Galphai/GTP)

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XHP0 325
xref: PTHR13809:SF5
organism: Macaca mulatta

uniprot Q61190 1244
type: UnificationXref
id: Q61190
db: uniprot

uniprot K7AE17 345
type: UnificationXref
id: K7AE17
db: uniprot

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot H2RB55 1476
organism: Pan troglodytes

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6VXG1 1365
organism: Xenopus tropicalis

uniprot P33896 1242
type: UnificationXref
id: P33896
db: uniprot

uniprot P09471 102
type: UnificationXref
id: P09471
db: uniprot

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 786
xref: PTHR10728:SF13
xref: uniprot P47712 793
organism: Homo sapiens

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 786
xref: PTHR10728:SF13
xref: uniprot P47713 794
organism: Mus musculus

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot P60709 1015
xref: PTHR11937:SF192
organism: Homo sapiens

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot P60706 1014
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y1M7 1293
xref: PTHR45615:SF39
organism: Macaca mulatta

uniprot F7E4E2 1298
type: UnificationXref
id: F7E4E2
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r24
controller: IP3

uniprot P02574 990
type: UnificationXref
id: P02574
db: uniprot

uniprot P24898 447
type: UnificationXref
id: P24898
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot P10824 103
organism: Rattus norvegicus

Calcium/calmodulin-dependent protein kinase type II subunit alpha
type: ProteinReference
xref: PTHR24347:SF384
xref: uniprot Q9UQM7 582
organism: Homo sapiens

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 287

uniprot A7SCN8 900
type: UnificationXref
id: A7SCN8
db: uniprot

uniprot Q62689 549
type: UnificationXref
id: Q62689
db: uniprot

uniprot A0A2I3TNH3 587
type: UnificationXref
id: A0A2I3TNH3
db: uniprot

PLA2
type: Protein
entity reference: PLA2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PDK1-RIGHT__PDK1-_r42
controller: PIP3

Rho-related GTP-binding protein RhoG
type: ProteinReference
xref: uniprot P84096 232
organism: Mus musculus

Myosin-8
type: ProteinReference
xref: uniprot P13542 1324
xref: PTHR45615:SF35
organism: Mus musculus

uniprot A8X1E0 1444
type: UnificationXref
id: A8X1E0
db: uniprot

GTPase KRas
type: ProteinReference
xref: uniprot P01116 1404
xref: PTHR24070:SF388
organism: Homo sapiens

Rho-related GTP-binding protein RhoG
type: ProteinReference
xref: uniprot P84095 231
organism: Homo sapiens

Myosin-3
type: ProteinReference
xref: uniprot P13541 1323
xref: PTHR45615:SF6
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF24
xref: uniprot A0A1D5NUE9 1249
organism: Gallus gallus

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P01111 1403
organism: Homo sapiens

uniprot Q39023 290
type: UnificationXref
id: Q39023
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
type: ProteinReference
xref: uniprot Q99P84 1524
organism: Rattus norvegicus

uniprot K7E435 646
type: UnificationXref
id: K7E435
db: uniprot

Integrin beta
type: ProteinReference
xref: uniprot A0A2I3RYR8 635
xref: PTHR10082:SF28
organism: Pan troglodytes

PTHR24347:SF412
type: RelationshipXref
id: PTHR24347:SF412
db: PANTHER Family
relationship type: By Homology

uniprot P32302 719
type: UnificationXref
id: P32302
db: uniprot

uniprot Q1KQ07 162
type: UnificationXref
id: Q1KQ07
db: uniprot

MEK
type: Protein
entity reference: MEK
feature: MEK s161 a235 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7G3I5 1371
type: UnificationXref
id: F7G3I5
db: uniprot

uniprot O55173 149
type: UnificationXref
id: O55173
db: uniprot

Interferon gamma
type: ProteinReference
xref: uniprot P42161 1662
xref: PTHR11419:SF0
organism: Canis lupus familiaris

uniprot A0A3S5ZPQ6 662
type: UnificationXref
id: A0A3S5ZPQ6
db: uniprot

MAPK
type: Protein
entity reference: MAPK
feature: MAPK s197 a239 rs1
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot E2RLH2 1117
organism: Canis lupus familiaris

Actin alpha 2, smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot Q6DHS1 1062
organism: Danio rerio

uniprot J9P309 1585
type: UnificationXref
id: J9P309
db: uniprot

Cell division cycle 42
type: ProteinReference
xref: PTHR24072:SF337
xref: uniprot Q52WY2 245
organism: Danio rerio

uniprot P13541 1323
type: UnificationXref
id: P13541
db: uniprot

RCG61633, isoform CRA_a
type: ProteinReference
xref: uniprot D3ZUE4 1669
xref: PTHR10155:SF15
organism: Rattus norvegicus

uniprot P49708 1663
type: UnificationXref
id: P49708
db: uniprot

PTHR24347:SF403
type: RelationshipXref
id: PTHR24347:SF403
db: PANTHER Family
relationship type: By Homology

uniprot P01111 1403
type: UnificationXref
id: P01111
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF11
xref: uniprot F7H582 470
organism: Macaca mulatta

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot F6SRP9 1461
organism: Macaca mulatta

PTHR24072:SF337
type: RelationshipXref
id: PTHR24072:SF337
db: PANTHER Family
relationship type: By Homology

uniprot Q9WUT7 781
type: UnificationXref
id: Q9WUT7
db: uniprot

uniprot F1PJ94 1099
type: UnificationXref
id: F1PJ94
db: uniprot

Rho
type: Protein
entity reference: Rho
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P30993 716
type: UnificationXref
id: P30993
db: uniprot

Rac
type: ProteinReference
xref: P00872
standard name: Ras-related C3 botulinum toxin substrate
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.Rac
comment: ENTITY_REFERENCE_NOTES=Long Name: Ras related C3 botulinum substrate 1 Synonym: Rac Accession: P00872
member entity reference: Ras-related C3 botulinum toxin substrate 1
member entity reference: Uncharacterized protein

a296_degraded
type: PhysicalEntity
cellular location: cytoplasm
comment: SPECIES_TYPE=DEGRADED

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GP56 1303
xref: PTHR45615:SF6
organism: Macaca mulatta

PTHR24418:SF94
type: RelationshipXref
id: PTHR24418:SF94
db: PANTHER Family
relationship type: By Homology

uniprot P90623 1042
type: UnificationXref
id: P90623
db: uniprot

PTHR22988:SF33
type: RelationshipXref
id: PTHR22988:SF33
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5R9U8 505
type: UnificationXref
id: A0A1D5R9U8
db: uniprot

C-C motif chemokine 3
type: ProteinReference
xref: uniprot Q5I1Z0 868
organism: Pan troglodytes

uniprot Q92352 1629
type: UnificationXref
id: Q92352
db: uniprot

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 922

uniprot E2RMT4 1563
type: UnificationXref
id: E2RMT4
db: uniprot

uniprot P82471 1430
type: UnificationXref
id: P82471
db: uniprot

uniprot Q5F3U4 150
type: UnificationXref
id: Q5F3U4
db: uniprot

STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r74
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 1821
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 1822
left: Ras
interaction type: STATE_TRANSITION
right: Ras

C-C chemokine receptor type 6
type: ProteinReference
xref: uniprot O54689 701
xref: PTHR10489:SF611
organism: Mus musculus

uniprot Q01970 1499
type: UnificationXref
id: Q01970
db: uniprot

uniprot P08753 100
type: UnificationXref
id: P08753
db: uniprot

PTHR24072:SF325
type: RelationshipXref
id: PTHR24072:SF325
db: PANTHER Family
relationship type: By Homology

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF2
xref: uniprot Q7PWN2 1626
organism: Anopheles gambiae

uniprot G2HG81 1579
type: UnificationXref
id: G2HG81
db: uniprot

Nuclear factor of activated T-cells 5
type: ProteinReference
xref: uniprot D3ZGB1 608
organism: Rattus norvegicus

INPPL1 isoform 1
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot H2Q4C6 452
organism: Pan troglodytes

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: uniprot Q9PSX7 1126
xref: PTHR24072:SF100
organism: Gallus gallus

Serine/threonine-protein kinase PAK 6
type: ProteinReference
xref: uniprot Q9NQU5 426
organism: Homo sapiens

uniprot P33766 720
type: UnificationXref
id: P33766
db: uniprot

PARTICIPANT STOICHIOMETRY r37 1841
type: Stoichiometry
physical entity: Arp2/3
stoichiometric coefficient: 1.0

uniprot F6T5Y1 1689
type: UnificationXref
id: F6T5Y1
db: uniprot

uniprot Q9XT45 783
type: UnificationXref
id: Q9XT45
db: uniprot

uniprot O97665 709
type: UnificationXref
id: O97665
db: uniprot

Rac family small GTPase 2
type: ProteinReference
xref: uniprot Q5U1Y2 246
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
type: ProteinReference
xref: uniprot Q8K3R3 1518
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Cdc42-RIGHT__Cdc42-_r33
controller: GEF

uniprot C3XYD3 933
type: UnificationXref
id: C3XYD3
db: uniprot

PTHR11462:SF8
type: RelationshipXref
id: PTHR11462:SF8
db: PANTHER Family
relationship type: By Homology

PTHR11462:SF7
type: RelationshipXref
id: PTHR11462:SF7
db: PANTHER Family
relationship type: By Homology

uniprot F6THF0 200
type: UnificationXref
id: F6THF0
db: uniprot

STATE_TRANSITION_LEFT__NFAT-RIGHT__NFAT-_r51
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 1913
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 1912
left: NFAT
interaction type: STATE_TRANSITION
right: NFAT

uniprot B1AR69 1264
type: UnificationXref
id: B1AR69
db: uniprot

PARTICIPANT STOICHIOMETRY r37 1840
type: Stoichiometry
physical entity: Arp2/3
stoichiometric coefficient: 1.0

uniprot Q4KWH5 1508
type: UnificationXref
id: Q4KWH5
db: uniprot

uniprot F7GP56 1303
type: UnificationXref
id: F7GP56
db: uniprot

uniprot F6VF32 1291
type: UnificationXref
id: F6VF32
db: uniprot

uniprot F1MZX6 1275
type: UnificationXref
id: F1MZX6
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 234

CCR4 protein
type: ProteinReference
xref: uniprot A6QLA5 664
xref: PTHR10489:SF608
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2RE16 392
organism: Canis lupus familiaris

Ashbya gossypii
type: BioSource
xref: ncbitaxon 284811 257

uniprot E1BP87 1270
type: UnificationXref
id: E1BP87
db: uniprot

Eotaxin
type: ProteinReference
xref: uniprot Q9TTS6 879
organism: Bos taurus

uniprot A0A2I3TIW8 1256
type: UnificationXref
id: A0A2I3TIW8
db: uniprot

uniprot P10301 1406
type: UnificationXref
id: P10301
db: uniprot

By Homology
type: RelationshipTypeVocabulary

uniprot B8JK39 638
type: UnificationXref
id: B8JK39
db: uniprot

uniprot Q9WV32 1642
type: UnificationXref
id: Q9WV32
db: uniprot

uniprot Q0VC91 1685
type: UnificationXref
id: Q0VC91
db: uniprot

uniprot H2QB15 1648
type: UnificationXref
id: H2QB15
db: uniprot

IL2
type: Protein
entity reference: IL2
feature: COMPLEX PARTICIPANT BINDING FEATURE s98 sa43 1767
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P10895 1489
type: UnificationXref
id: P10895
db: uniprot

uniprot Q04400 478
type: UnificationXref
id: Q04400
db: uniprot

uniprot Q3ZB92 1175
type: UnificationXref
id: Q3ZB92
db: uniprot

uniprot O88410 705
type: UnificationXref
id: O88410
db: uniprot

uniprot A0A2J8PX74 802
type: UnificationXref
id: A0A2J8PX74
db: uniprot

uniprot P10894 1488
type: UnificationXref
id: P10894
db: uniprot

uniprot P60710 1016
type: UnificationXref
id: P60710
db: uniprot

uniprot Q076A5 1330
type: UnificationXref
id: Q076A5
db: uniprot

uniprot Q08E52 413
type: UnificationXref
id: Q08E52
db: uniprot

ncbitaxon 284591 1087
type: UnificationXref
id: 284591
db: ncbitaxon

uniprot E2R2S3 312
type: UnificationXref
id: E2R2S3
db: uniprot

Complex (NFkappaB/IkappaB)
type: Complex
component stoichiometry: NFkappaB s107 sa49 STOICHIOMETRY ID COMPLEX
component stoichiometry: IkappaB s108 sa50 STOICHIOMETRY ID COMPLEX
component: IkappaB
component: NFkappaB
feature: COMPLEX BINDING FEATURE s203 a295 1760
feature: COMPLEX BINDING FEATURE s203 a295 1762
cellular location: cytoplasm

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot F1MX38 154
organism: Bos taurus

uniprot P29992 32
type: UnificationXref
id: P29992
db: uniprot

uniprot Q3SXG2 764
type: UnificationXref
id: Q3SXG2
db: uniprot

uniprot E2R2N2 266
type: UnificationXref
id: E2R2N2
db: uniprot

uniprot P31749 65
type: UnificationXref
id: P31749
db: uniprot

Protein CBR-MIG-2
type: ProteinReference
xref: uniprot A8XQS8 183
organism: Caenorhabditis briggsae

uniprot E2REH3 393
type: UnificationXref
id: E2REH3
db: uniprot

Prostaglandin G/H synthase 1
type: ProteinReference
xref: PTHR11903:SF6
xref: uniprot P22437 534
organism: Mus musculus

uniprot A0A3Q1LSY0 382
type: UnificationXref
id: A0A3Q1LSY0
db: uniprot

SOCS4 isoform 1
type: ProteinReference
xref: uniprot K7BMJ0 1680
xref: PTHR10155:SF21
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EPQ4 128
xref: PTHR11771:SF33
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5NUC4 1227
organism: Gallus gallus

Integrin beta-1
type: ProteinReference
xref: PTHR10082:SF28
xref: uniprot P09055 649
organism: Mus musculus

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot F1MX21 486
organism: Bos taurus

uniprot P07353 1661
type: UnificationXref
id: P07353
db: uniprot

uniprot Q076A8 1332
type: UnificationXref
id: Q076A8
db: uniprot

uniprot Q9I8V1 1083
type: UnificationXref
id: Q9I8V1
db: uniprot

JunD proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: PTHR11462:SF7
xref: uniprot F1PKI6 431
organism: Canis lupus familiaris

uniprot F7GU82 1470
type: UnificationXref
id: F7GU82
db: uniprot

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 1003

uniprot P15066 441
type: UnificationXref
id: P15066
db: uniprot

uniprot Q8NEV4 1343
type: UnificationXref
id: Q8NEV4
db: uniprot

uniprot F6T2E7 397
type: UnificationXref
id: F6T2E7
db: uniprot

Cytokine receptor
type: Protein
entity reference: Cytokine receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s95 sa42 1765
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q5M8T9 1057
type: UnificationXref
id: Q5M8T9
db: uniprot

uniprot O14921 172
type: UnificationXref
id: O14921
db: uniprot

JAK
type: Protein
entity reference: JAK
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Alpha-cardiac actin
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot F7F210 977
organism: Macaca mulatta

uniprot F6UJE8 89
type: UnificationXref
id: F6UJE8
db: uniprot

Actin-related protein 2/3 complex subunit 5-like protein
type: ProteinReference
xref: uniprot Q5E963 1621
xref: PTHR12644:SF2
organism: Bos taurus

uniprot P70600 632
type: UnificationXref
id: P70600
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IkappaB-RIGHT__IkappaB-_r46
controller: IKK

uniprot H3FK05 208
type: UnificationXref
id: H3FK05
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot V5IKE7 307
xref: PTHR24055:SF158
organism: Neurospora crassa

IL2
type: Protein
entity reference: IL2
feature: COMPLEX PARTICIPANT BINDING FEATURE s92 sa41 1741
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q9Z1L0 1392
type: UnificationXref
id: Q9Z1L0
db: uniprot

uniprot P50148 38
type: UnificationXref
id: P50148
db: uniprot

Myosin, heavy chain a
type: ProteinReference
xref: uniprot F1R6C7 1286
organism: Danio rerio

uniprot C3XYC6 930
type: UnificationXref
id: C3XYC6
db: uniprot

uniprot F1LQ70 127
type: UnificationXref
id: F1LQ70
db: uniprot

Actin
type: ProteinReference
xref: uniprot Q67G20 1061
xref: PTHR11937:SF474
organism: Oryza sativa

PTHR11937:SF389
type: RelationshipXref
id: PTHR11937:SF389
db: PANTHER Family
relationship type: By Homology

uniprot Q02158 1500
type: UnificationXref
id: Q02158
db: uniprot

uniprot P14681 277
type: UnificationXref
id: P14681
db: uniprot

uniprot F6RCU6 60
type: UnificationXref
id: F6RCU6
db: uniprot

PTHR11937:SF387
type: RelationshipXref
id: PTHR11937:SF387
db: PANTHER Family
relationship type: By Homology

Galphai q s8 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Galphai/q
stoichiometric coefficient: 1.0

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot F6V946 515
organism: Xenopus tropicalis

uniprot F7AGY1 1201
type: UnificationXref
id: F7AGY1
db: uniprot

uniprot C3XYC8 932
type: UnificationXref
id: C3XYC8
db: uniprot

uniprot P97711 462
type: UnificationXref
id: P97711
db: uniprot

PTHR24347:SF365
type: RelationshipXref
id: PTHR24347:SF365
db: PANTHER Family
relationship type: By Homology

PTHR24347:SF373
type: RelationshipXref
id: PTHR24347:SF373
db: PANTHER Family
relationship type: By Homology

PTHR45627:SF7
type: RelationshipXref
id: PTHR45627:SF7
db: PANTHER Family
relationship type: By Homology

PTHR24055:SF158
type: RelationshipXref
id: PTHR24055:SF158
db: PANTHER Family
relationship type: By Homology

PAK
type: ProteinReference
xref: P00837
standard name: P21-activated kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: P21-activated kinase Synonym: PAK Accession: P00837
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.PAK
member entity reference: Serine/threonine-protein kinase PAK 5
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: Serine/threonine-protein kinase PAK 6
member entity reference: Serine/threonine-protein kinase pak-1
member entity reference: Serine/threonine-protein kinase PAK 3
member entity reference: Serine/threonine-protein kinase PAK 2
member entity reference: Serine/threonine-protein kinase PAK 1
member entity reference: Serine/threonine-protein kinase PAK 4
member entity reference: Serine/threonine-protein kinase PAK mbt
member entity reference: Uncharacterized protein

PTHR45627:SF6
type: RelationshipXref
id: PTHR45627:SF6
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF397
type: RelationshipXref
id: PTHR11937:SF397
db: PANTHER Family
relationship type: By Homology

Myosin-IIIa
type: ProteinReference
xref: uniprot Q8K3H5 1342
organism: Mus musculus

uniprot Q5U2Z4 1110
type: UnificationXref
id: Q5U2Z4
db: uniprot

uniprot H2KNE6 980
type: UnificationXref
id: H2KNE6
db: uniprot

C-C motif chemokine 8
type: ProteinReference
xref: uniprot P80075 858
organism: Homo sapiens

MYH11 protein
type: ProteinReference
xref: uniprot A6QLN6 1261
xref: PTHR45615:SF23
organism: Bos taurus

uniprot Q7ZW82 117
type: UnificationXref
id: Q7ZW82
db: uniprot

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot Q05144 237
organism: Mus musculus

Serine/threonine-protein kinase PAK mbt
type: ProteinReference
xref: uniprot Q9VXE5 428
organism: Drosophila melanogaster

uniprot F6R8N3 59
type: UnificationXref
id: F6R8N3
db: uniprot

uniprot O93467 1120
type: UnificationXref
id: O93467
db: uniprot

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 898

uniprot E1BCP6 543
type: UnificationXref
id: E1BCP6
db: uniprot

uniprot P53501 1012
type: UnificationXref
id: P53501
db: uniprot

C-C motif chemokine 7
type: ProteinReference
xref: uniprot P80098 859
organism: Homo sapiens

uniprot Q9WTK5 1113
type: UnificationXref
id: Q9WTK5
db: uniprot

uniprot A0A2J8PAG2 661
type: UnificationXref
id: A0A2J8PAG2
db: uniprot

uniprot P26010 653
type: UnificationXref
id: P26010
db: uniprot

uniprot F7A472 91
type: UnificationXref
id: F7A472
db: uniprot

IkappaB
type: ProteinReference
xref: P00857
standard name: Inhibitor of kappa light chain gene enhancer in B cells
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Inhibitor of kappa light chain gene enhancer in B cells Synonym: NFKBI,Nuclear factor of kappa light chain gene enhancer in B cells inhibitor Accession: P00857
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.I_kappa_B
member entity reference: NF-kappa-B inhibitor alpha

AC
type: ProteinReference
xref: P00841
standard name: adenylate cyclase
comment: ENTITY_REFERENCE_NOTES=Long Name: Adenylyl cyclase Synonym: Synonym not specified Accession: P00841
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.AC
member entity reference: Adenylate cyclase type 5
member entity reference: Adenylate cyclase type 6
member entity reference: Adenylate cyclase
member entity reference: Adenylate cyclase type 2

uniprot B3RX77 923
type: UnificationXref
id: B3RX77
db: uniprot

PAK
type: Protein
entity reference: PAK
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q14573 501
type: UnificationXref
id: Q14573
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QLB4 273
xref: PTHR24055:SF203
organism: Pan troglodytes

STATE_TRANSITION_LEFT__GEF-RIGHT__GEF-_r30
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 1864
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 1863
left: GEF
interaction type: STATE_TRANSITION
right: GEF

PTEN
type: ProteinReference
xref: P00849
standard name: Phosphatase and tensin homologue
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.PTEN
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphatase and tensin homologue Synonym: PTEN Accession: P00849
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
member entity reference: Uncharacterized protein

Interferon alpha/beta receptor 1
type: ProteinReference
xref: PTHR20859:SF54
xref: uniprot P33896 1242
organism: Mus musculus

uniprot P10686 1485
type: UnificationXref
id: P10686
db: uniprot

uniprot H2QJY5 1474
type: UnificationXref
id: H2QJY5
db: uniprot

Cytokine receptor s30 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cytokine receptor
stoichiometric coefficient: 2.0

Interferon gamma
type: ProteinReference
xref: uniprot P07353 1661
xref: PTHR11419:SF0
organism: Bos taurus

uniprot Q3ZC07 1049
type: UnificationXref
id: Q3ZC07
db: uniprot

CHK
type: Protein
entity reference: CHK
feature: COMPLEX PARTICIPANT BINDING FEATURE s208 sa160 1717
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5NUE9 1249
type: UnificationXref
id: A0A1D5NUE9
db: uniprot

Complex (CHKR/Galphai/ q/GDP/ Gbetagamma)
type: Complex
component stoichiometry: CHKR s1 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: Galphai q s3 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbetagamma s5 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s4 sa3 STOICHIOMETRY ID COMPLEX
component: CHKR
component: Gbetagamma
component: GDP
component: Galphai/q
feature: COMPLEX BINDING FEATURE s13 a15 1708
feature: COMPLEX BINDING FEATURE s13 a15 1706
feature: COMPLEX BINDING FEATURE s13 a15 1702
feature: COMPLEX BINDING FEATURE s13 a15 1704
cellular location: cytoplasm

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot A0A1D5Q5Z6 261
organism: Macaca mulatta

Cytohesin-2
type: ProteinReference
xref: uniprot A0A3Q1LM77 1534
xref: PTHR10663:SF363
organism: Bos taurus

G protein-coupled receptor kinase 6
type: ProteinReference
xref: PTHR24355:SF15
xref: uniprot P43250 461
organism: Homo sapiens

uniprot Q7ZVI7 1076
type: UnificationXref
id: Q7ZVI7
db: uniprot

Myosin-10
type: ProteinReference
xref: PTHR45615:SF24
xref: uniprot P35580 1326
organism: Homo sapiens

uniprot P56483 745
type: UnificationXref
id: P56483
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot Q9VXH3 1530
organism: Drosophila melanogaster

AKT
type: ProteinReference
xref: P00827
standard name: protein kinase B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: protein kinase B Synonym: AKT,PKB Accession: P00827
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.AKT
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC-alpha serine/threonine-protein kinase
member entity reference: RAC-beta serine/threonine-protein kinase
member entity reference: RAC-gamma serine/threonine-protein kinase
member entity reference: RAC serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase akt-1
member entity reference: Serine/threonine-protein kinase akt-2

uniprot F6ZZG9 970
type: UnificationXref
id: F6ZZG9
db: uniprot

uniprot Q00743 109
type: UnificationXref
id: Q00743
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot G2HG81 1579
xref: PTHR12644:SF1
organism: Pan troglodytes

Putative actin-5
type: ProteinReference
xref: PTHR11937:SF411
xref: uniprot Q8RYC2 1081
organism: Arabidopsis thaliana

Myosin-9
type: ProteinReference
xref: uniprot F1P9J3 1279
xref: PTHR45615:SF16
organism: Canis lupus familiaris

C-C motif chemokine 2
type: ProteinReference
xref: uniprot P13500 837
organism: Homo sapiens

Gbetagamma
type: ProteinReference
xref: P00836
standard name: G protein, beta and gamma subunit
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.G_beta__gamma_
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: G beta/gamma subunits Synonym: Synonym not specified Accession: P00836
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
member entity reference: Uncharacterized protein
member entity reference: G protein subunit gamma 5
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: Guanine nucleotide-binding protein subunit gamma-1
member entity reference: G protein subunit beta 3

C-C motif chemokine 5
type: ProteinReference
xref: PTHR12015:SF170
xref: uniprot P13501 838
organism: Homo sapiens

uniprot Q90Z40 375
type: UnificationXref
id: Q90Z40
db: uniprot

COL12A1 isoform 1
type: ProteinReference
xref: PTHR24020:SF17
xref: uniprot H2QTA4 1207
organism: Pan troglodytes

KRAS isoform 4
type: ProteinReference
xref: uniprot A0A2I3T6U4 1393
xref: PTHR24070:SF388
organism: Pan troglodytes

PTHR24055:SF196
type: RelationshipXref
id: PTHR24055:SF196
db: PANTHER Family
relationship type: By Homology

uniprot Q148F2 143
type: UnificationXref
id: Q148F2
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot F1NT98 589
xref: PTHR12305:SF81
organism: Gallus gallus

PTHR11937:SF359
type: RelationshipXref
id: PTHR11937:SF359
db: PANTHER Family
relationship type: By Homology

uniprot P30804 474
type: UnificationXref
id: P30804
db: uniprot

Galphai/q
type: Protein
entity reference: Galphai/q
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa7 1727
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 7719 889
type: UnificationXref
id: 7719
db: ncbitaxon

uniprot F1P9J3 1279
type: UnificationXref
id: F1P9J3
db: uniprot

uniprot O80856 1592
type: UnificationXref
id: O80856
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot F1A175 953
organism: Dictyostelium purpureum

uniprot P10687 1486
type: UnificationXref
id: P10687
db: uniprot

uniprot F6XMN6 121
type: UnificationXref
id: F6XMN6
db: uniprot

Jun proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot E2R6T4 430
organism: Canis lupus familiaris

uniprot P55774 852
type: UnificationXref
id: P55774
db: uniprot

Arp2/3 complex 34 kDa subunit
type: ProteinReference
xref: PTHR12058:SF0
xref: uniprot F1P1K3 1565
organism: Gallus gallus

STAT
type: Protein
entity reference: STAT
feature: COMPLEX PARTICIPANT BINDING FEATURE s104 sa46 1779
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F6XHP0 325
type: UnificationXref
id: F6XHP0
db: uniprot

PTHR11937:SF362
type: RelationshipXref
id: PTHR11937:SF362
db: PANTHER Family
relationship type: By Homology

uniprot Q61036 419
type: UnificationXref
id: Q61036
db: uniprot

uniprot Q13464 1692
type: UnificationXref
id: Q13464
db: uniprot

PTHR24347:SF384
type: RelationshipXref
id: PTHR24347:SF384
db: PANTHER Family
relationship type: By Homology

uniprot F7HAF3 791
type: UnificationXref
id: F7HAF3
db: uniprot

uniprot F1PKI6 431
type: UnificationXref
id: F1PKI6
db: uniprot

uniprot Q32MK0 1655
type: UnificationXref
id: Q32MK0
db: uniprot

uniprot Q08462 479
type: UnificationXref
id: Q08462
db: uniprot

Myosin
type: Protein
entity reference: Myosin
feature: Myosin s71 a109 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Myosin-9
type: ProteinReference
xref: uniprot P35579 1325
xref: PTHR45615:SF16
organism: Homo sapiens

IKK
type: ProteinReference
xref: P00871
standard name: Inhibitor of kappa-B kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.GENERIC.IKK
comment: ENTITY_REFERENCE_NOTES=Long Name: I-kappa B kinase Synonym: IKK Accession: P00871
member entity reference: Inhibitor of nuclear factor kappa-B kinase subunit epsilon
member entity reference: Conserved helix-loop-helix ubiquitous kinase
member entity reference: Inhibitor of nuclear factor kappa-B kinase subunit alpha
member entity reference: Uncharacterized protein
member entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta
member entity reference: Inhibitor of kappaB kinase epsilon (Predicted)
member entity reference: Inhibitor of nuclear factor kappa B kinase subunit beta

Actin
type: ProteinReference
xref: PTHR11937:SF248
xref: uniprot Q75HX0 1072
organism: Oryza sativa

uniprot A0A2I3RV12 1436
type: UnificationXref
id: A0A2I3RV12
db: uniprot

CHKR
type: Protein
entity reference: CHKR
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa5 1723
feature: ACTIVE 46
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot F7BZM9 1573
organism: Monodelphis domestica

PTHR24347:SF394
type: RelationshipXref
id: PTHR24347:SF394
db: PANTHER Family
relationship type: By Homology

PIK3CG isoform 1
type: ProteinReference
xref: uniprot A0A2J8QY32 1357
xref: PTHR10048:SF34
organism: Pan troglodytes

PTHR24347:SF398
type: RelationshipXref
id: PTHR24347:SF398
db: PANTHER Family
relationship type: By Homology

PTHR11462:SF35
type: RelationshipXref
id: PTHR11462:SF35
db: PANTHER Family
relationship type: By Homology

uniprot Q3KRE3 369
type: UnificationXref
id: Q3KRE3
db: uniprot

uniprot Q3LSL6 763
type: UnificationXref
id: Q3LSL6
db: uniprot

Myosin-8
type: ProteinReference
xref: PTHR45615:SF35
xref: uniprot P13535 1322
organism: Homo sapiens

uniprot Q04970 1408
type: UnificationXref
id: Q04970
db: uniprot

Myosin-6
type: ProteinReference
xref: uniprot P13533 1321
xref: PTHR45615:SF11
organism: Homo sapiens

PTHR11462:SF37
type: RelationshipXref
id: PTHR11462:SF37
db: PANTHER Family
relationship type: By Homology

Suppressor of cytokine signaling 5
type: ProteinReference
xref: uniprot O75159 1684
xref: PTHR10155:SF15
organism: Homo sapiens

Integrin
type: ProteinReference
xref: P00853
comment: ENTITY_REFERENCE_ID_DESC=Inflammation mediated by chemokine and cytokine signaling pathway.PROTEIN.RECEPTOR.Integrin
comment: ENTITY_REFERENCE_NOTES=Long Name: Integrin Synonym: Synonym not specified Accession: P00853
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Integrin alpha-L
member entity reference: Integrin alpha-9
member entity reference: Integrin beta-1
member entity reference: Integrin beta-2
member entity reference: Integrin beta
member entity reference: Integrin beta-7
member entity reference: Integrin alpha-M
member entity reference: Integrin subunit alpha 4
member entity reference: Integrin subunit alpha 9
member entity reference: Integrin alpha-4
member entity reference: ITGA9 isoform 2