GO GO:0005634 2
type: UnificationXref
id: GO:0005634
db: GO

uniprot P01344 67
type: UnificationXref
id: P01344
db: uniprot

MDM2 proto-oncogene
type: ProteinReference
xref: PTHR13844:SF15
xref: uniprot A0A2I3RE00 132
organism: Pan troglodytes

TRANSCRIPTION_LEFT__PTEN-RIGHT__PTEN-_re43
type: TemplateReaction
product: PTEN
xref: TRANSCRIPTION
participant: PTEN
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Insulin
type: ProteinReference
xref: uniprot P30410 76
organism: Pan troglodytes

uniprot F7G3I5 198
type: UnificationXref
id: F7G3I5
db: uniprot

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot A0A2I3RFV3 13
xref: PTHR24416:SF535
organism: Pan troglodytes

GO GO:0005829 3
type: UnificationXref
id: GO:0005829
db: GO

P110alpha
type: Protein
entity reference: P110alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa4 226
feature: ACTIVE 4
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Insulin IGF
type: Protein
entity reference: Insulin IGF
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa1 220
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 2

uniprot A4IGV9 53
type: UnificationXref
id: A4IGV9
db: uniprot

TRANSCRIPTION_LEFT__Mdm2-RIGHT__Mdm2-_re44
type: TemplateReaction
product: Mdm2
xref: TRANSCRIPTION
participant: Mdm2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Glucose depreivation response
controller: Complex (Tsc1/Tsc2)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6SW23 195
xref: PTHR10048:SF107
organism: Gallus gallus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: DnaReference
xref: PTHR10048:SF107
organism: Mus musculus

ncbitaxon 559292 179
type: UnificationXref
id: 559292
db: ncbitaxon

PiP2
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot G3V7R4 93
type: UnificationXref
id: G3V7R4
db: uniprot

Insulin IGF s3 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Insulin IGF
stoichiometric coefficient: 1.0

uniprot P60483 213
type: UnificationXref
id: P60483
db: uniprot

Tsc2 s62 a106 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Forkhead box protein O1
type: ProteinReference
xref: uniprot Q12778 97
organism: Homo sapiens

Insulin receptor substrate 4
type: ProteinReference
xref: uniprot O14654 109
xref: PTHR10614:SF2
organism: Homo sapiens

INSR IGF R IRR s4 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: INSR IGF-R IRR
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Xenopus tropicalis

eco ECO:0000250 7
type: UnificationXref
id: ECO:0000250
db: eco

uniprot H2R875 137
type: UnificationXref
id: H2R875
db: uniprot

Os01g0872800 protein
type: ProteinReference
xref: uniprot Q8RUE8 184
xref: PTHR24356:SF163
organism: Oryza sativa

Insulin-like growth factor I
type: ProteinReference
xref: uniprot P08025 73
organism: Rattus norvegicus

uniprot O15530 176
type: UnificationXref
id: O15530
db: uniprot

ncbitaxon 44689 190
type: UnificationXref
id: 44689
db: ncbitaxon

Mus musculus
type: BioSource
xref: ncbitaxon 10090 46

Tsc1
type: Protein
entity reference: Tsc1
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa8 230
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot B0R0Q2 16
type: UnificationXref
id: B0R0Q2
db: uniprot

AKT
type: Protein
feature: ACTIVE 4
feature: PKB s37 a57 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot O15357 86
type: UnificationXref
id: O15357
db: uniprot

Insulin receptor substrate 1
type: ProteinReference
xref: uniprot F1MYE0 105
xref: PTHR10614:SF11
organism: Bos taurus

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q9XF67 187
organism: Arabidopsis thaliana

uniprot P83101 161
type: UnificationXref
id: P83101
db: uniprot

uniprot A0A0G2K5T3 192
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LJI4 146
xref: PTHR24057:SF14
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42336 201
organism: Homo sapiens

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 179

Insulin-like growth factor II
type: ProteinReference
xref: PTHR46886:SF1
xref: uniprot P09535 74
organism: Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42337 202
organism: Mus musculus

uniprot F1MC23 22
type: UnificationXref
id: F1MC23
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 41

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Mus musculus

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: uniprot F1MYE6 134
xref: PTHR13844:SF15
organism: Bos taurus

Complex (PI3-K/P110alpha)
type: Complex
component stoichiometry: P110alpha s10 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: PI3 K s6 sa3 STOICHIOMETRY ID COMPLEX
component: P110alpha
component: PI3-K
feature: COMPLEX BINDING FEATURE s59 a88 223
feature: COMPLEX BINDING FEATURE s59 a88 225
cellular location: cytosol

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q071 82
xref: PTHR46051:SF2
organism: Macaca mulatta

STATE_TRANSITION_LEFT__PiP2-RIGHT__PiP3-_r19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 254
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 255
left: PiP2
interaction type: STATE_TRANSITION
right: PiP3

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot O08586 210
organism: Mus musculus

Tyrosine-protein kinase receptor
type: ProteinReference
xref: PTHR24416:SF106
xref: uniprot F6SJA3 28
organism: Monodelphis domestica

uniprot F6PZT8 55
type: UnificationXref
id: F6PZT8
db: uniprot

P04498
type: UnificationXref
id: P04498
db: PANTHER Pathway Component

P04496
type: UnificationXref
id: P04496
db: PANTHER Pathway Component

P04495
type: UnificationXref
id: P04495
db: PANTHER Pathway Component

GSK 3 s43 a62 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

P04494
type: UnificationXref
id: P04494
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r19 254
type: Stoichiometry
physical entity: PiP2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r19 255
type: Stoichiometry
physical entity: PiP3
stoichiometric coefficient: 1.0

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A
type: ProteinReference
xref: uniprot Q9LT75 218
organism: Arabidopsis thaliana

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: PTHR13844:SF15
xref: uniprot P23804 142
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__PI3_K-_P110alpha-RIGHT__Complex__PI3_K_P110alpha_-_re25
controller: IRS 1-4

Cell survival maintenance
type: Pathway

Glycogen synthase kinase-3 alpha
type: ProteinReference
xref: uniprot P49840 159
xref: PTHR24057:SF14
organism: Homo sapiens

Tsc1 s14 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Tsc1
stoichiometric coefficient: 1.0

uniprot Q5F3U4 183
type: UnificationXref
id: Q5F3U4
db: uniprot

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: uniprot P49841 160
xref: PTHR24057:SF8
organism: Homo sapiens

uniprot F7ACT4 154
type: UnificationXref
id: F7ACT4
db: uniprot

Insulin-like growth factor II
type: ProteinReference
xref: uniprot P33717 77
xref: PTHR46886:SF1
organism: Gallus gallus

uniprot H2Q4C6 85
type: UnificationXref
id: H2Q4C6
db: uniprot

AKT
type: Protein
feature: PKB s35 a53 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

E3 ubiquitin-protein ligase Mdm2
type: DnaReference
xref: PTHR13844:SF15
organism: Rattus norvegicus

INSR IGF-R IRR
type: Protein
entity reference: INSR IGF-R IRR
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa2 222
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 173

Glycogen synthesis
type: Pathway

PI3-K
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P23804 142
type: UnificationXref
id: P23804
db: uniprot

IRS1 isoform 1
type: ProteinReference
xref: uniprot H2QJJ4 108
xref: PTHR10614:SF11
organism: Pan troglodytes

Glycogen synthase kinase 3 alpha
type: ProteinReference
xref: uniprot H2QGF9 155
xref: PTHR24057:SF14
organism: Pan troglodytes

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot F7ACT4 154
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2TVV5 147
xref: PTHR24057:SF8
organism: Gallus gallus

Tyrosine-protein kinase receptor
type: ProteinReference
xref: PTHR24416:SF338
xref: uniprot A0A2I3S4A3 15
organism: Pan troglodytes

3-phosphoinositide dependent protein kinase 1
type: ProteinReference
xref: uniprot A0A2I3TN41 174
xref: PTHR24356:SF163
organism: Pan troglodytes

Insulin receptor-related protein
type: ProteinReference
xref: PTHR24416:SF338
xref: uniprot Q64716 50
organism: Rattus norvegicus

uniprot P33717 77
type: UnificationXref
id: P33717
db: uniprot

PARTICIPANT STOICHIOMETRY re25 256
type: Stoichiometry
physical entity: PI3-K
stoichiometric coefficient: 1.0

uniprot Q9LT75 218
type: UnificationXref
id: Q9LT75
db: uniprot

uniprot P24062 47
type: UnificationXref
id: P24062
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Homo sapiens

Insulin
type: ProteinReference
xref: uniprot A4IGV9 53
organism: Xenopus tropicalis

ncbitaxon 7227 41
type: UnificationXref
id: 7227
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re25 257
type: Stoichiometry
physical entity: P110alpha
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re25 258
type: Stoichiometry
physical entity: Complex (PI3-K/P110alpha)
stoichiometric coefficient: 1.0

TRANSLATION
type: RelationshipTypeVocabulary

INSR IGF-R IRR
type: Protein
entity reference: INSR IGF-R IRR
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1N4K5 90
type: UnificationXref
id: F1N4K5
db: uniprot

uniprot Q12236 181
type: UnificationXref
id: Q12236
db: uniprot

uniprot E2RPM8 21
type: UnificationXref
id: E2RPM8
db: uniprot

uniprot Q9R1E0 100
type: UnificationXref
id: Q9R1E0
db: uniprot

uniprot Q9EP53 129
type: UnificationXref
id: Q9EP53
db: uniprot

uniprot Q9YH61 171
type: UnificationXref
id: Q9YH61
db: uniprot

Insulin
type: ProteinReference
xref: uniprot O73727 60
organism: Danio rerio

uniprot A0A2I3TN41 174
type: UnificationXref
id: A0A2I3TN41
db: uniprot

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 14

ncbitaxon 39947 185
type: UnificationXref
id: 39947
db: ncbitaxon

GSK-3
type: Protein
entity reference: GSK-3
feature: GSK 3 s43 a62 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 26

Mdm2
type: Protein
entity reference: Mdm2
feature: Mdm2 s54 a81 rs1
feature: ACTIVE 4
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MDX9 205
xref: PTHR12305:SF81
organism: Bos taurus

uniprot Q61037 125
type: UnificationXref
id: Q61037
db: uniprot

Insulin IGF
type: Protein
entity reference: Insulin IGF
comment: SPECIES_TYPE=PROTEIN

Protein Mdm4
type: ProteinReference
xref: uniprot Q5XIN1 144
organism: Rattus norvegicus

Tsc1
type: Protein
entity reference: Tsc1
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa5 232
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Cation-independent mannose-6-phosphate receptor
type: ProteinReference
xref: uniprot P08169 39
xref: PTHR15071:SF17
organism: Bos taurus

Insulin receptor substrate 1
type: ProteinReference
xref: PTHR10614:SF13
xref: uniprot Q9XTN2 114
organism: Drosophila melanogaster

FKHR s41 a61 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.7040297999055483

Insulin-like growth factor 1 receptor
type: ProteinReference
xref: PTHR24416:SF106
xref: uniprot P08069 37
organism: Homo sapiens

uniprot C4A0B6 17
type: UnificationXref
id: C4A0B6
db: uniprot

Tuberin
type: ProteinReference
xref: PTHR10063:SF0
xref: uniprot Q61037 125
organism: Mus musculus

uniprot Q9WVR3 88
type: UnificationXref
id: Q9WVR3
db: uniprot

uniprot H2QGF9 155
type: UnificationXref
id: H2QGF9
db: uniprot

uniprot Q9WTL4 51
type: UnificationXref
id: Q9WTL4
db: uniprot

Forkhead box protein O3
type: ProteinReference
xref: uniprot Q9WVH4 101
xref: PTHR45767:SF4
organism: Mus musculus

ncbitaxon 3702 188
type: UnificationXref
id: 3702
db: ncbitaxon

PTHR24356:SF368
type: RelationshipXref
id: PTHR24356:SF368
db: PANTHER Family
relationship type: By Homology

PTHR15154:SF2
type: RelationshipXref
id: PTHR15154:SF2
db: PANTHER Family
relationship type: By Homology

uniprot H2Q7G4 94
type: UnificationXref
id: H2Q7G4
db: uniprot

ncbitaxon 284812 167
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot E1BBJ7 83
type: UnificationXref
id: E1BBJ7
db: uniprot

uniprot K7B5K7 34
type: UnificationXref
id: K7B5K7
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot A0A2I3T7A8 193
xref: PTHR10048:SF107
organism: Pan troglodytes

uniprot H2QA49 33
type: UnificationXref
id: H2QA49
db: uniprot

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: uniprot O42354 141
xref: PTHR13844:SF15
organism: Danio rerio

phospatase and tensin homologue
type: DnaRegionReference
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A
member entity reference: MCG118205, isoform CRA_c
member entity reference: Putative tyrosine-protein phosphatase TPTE
member entity reference: IP16020p
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
xref: G04675
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.GENE.GENE.PTEN
comment: ENTITY_REFERENCE_NOTES=Long Name: PTEN Synonym: Synonym not specified Accession: G04675
display name: PTEN

uniprot P11717 42
type: UnificationXref
id: P11717
db: uniprot

uniprot Q90VV9 81
type: UnificationXref
id: Q90VV9
db: uniprot

PARTICIPANT STOICHIOMETRY r1 265
type: Stoichiometry
physical entity: Complex (Insulin IGF/INSR IGF-R IRR)
stoichiometric coefficient: 1.0

s77
type: PhysicalEntity
cellular location: cytosol
comment: SPECIES_TYPE=DEGRADED

uniprot P49816 123
type: UnificationXref
id: P49816
db: uniprot

uniprot F1PAE3 152
type: UnificationXref
id: F1PAE3
db: uniprot

Insulin/IGF pathway-protein kinase B signaling cascade
type: Pathway
pathway component: TRANSLATION_LEFT__p110alpha-RIGHT__P110alpha-_re40
pathway component: PHYSICAL_STIMULATION
pathway component: STATE_TRANSITION_LEFT__PDK1_2-RIGHT__PDK1_2-_r21
pathway component: STATE_TRANSITION_LEFT__IRS_1_4-_ATP-RIGHT__IRS_1_4-_ADP-_r2
pathway component: DISSOCIATION_LEFT__Complex__Tsc2_Tsc1_-RIGHT__Tsc2-_Tsc1-_re38
pathway component: HETERODIMER_ASSOCIATION_LEFT__PI3_K-_P110alpha-RIGHT__Complex__PI3_K_P110alpha_-_re25
pathway component: STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re22
pathway component: TRANSLATION_LEFT__Mdm2-RIGHT__Mdm2-_re39
pathway component: STATE_TRANSITION_LEFT__p53-RIGHT__s77-_re47
pathway component: STATE_TRANSITION_LEFT__PiP2-RIGHT__PiP3-_r19
pathway component: TRANSLATION_LEFT__PTEN-RIGHT__PTEN-_re41
pathway component: HETERODIMER_ASSOCIATION_LEFT__INSR_IGF_R_IRR-_Insulin_IGF-RIGHT__Complex__Insulin_IGF_INSR_IGF_R_IRR_-_r1
pathway component: STATE_TRANSITION_LEFT__GSK_3-_ATP-RIGHT__ADP-_GSK_3-_r24
pathway component: TRANSCRIPTION_LEFT__PTEN-RIGHT__PTEN-_re43
pathway component: TRANSPORT_LEFT__FKHR-RIGHT__FKHR-_r30
pathway component: TRANSCRIPTION_LEFT__Mdm2-RIGHT__Mdm2-_re44
pathway component: STATE_TRANSITION_LEFT__AKT-_ATP-RIGHT__ADP-_AKT-_r22
pathway component: STATE_TRANSITION_LEFT__PiP3-RIGHT__PiP2-_r20
pathway component: STATE_TRANSITION_LEFT__ATP-_FKHR-RIGHT__FKHR-_ADP-_r26
pathway component: STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re19
pathway component: STATE_TRANSITION_LEFT__Complex__Tsc1_Tsc2_-RIGHT__Complex__Tsc2_Tsc1_-_re37
pathway component: TRANSCRIPTION_LEFT__p110alpha-RIGHT__p110alpha-_re42
xref: PANTHER Pathway P00033 1
comment: MODEL_NOTES=Panther Pathway: P00033 The insulin receptor (IR), insulin-like growth factor receptor (IGFR), and insulin-receptor-related receptor (IRR) form a subgroup of receptor tyrosine kinases involved in regulating cellular growth and organismal metabolism. The activated IR regulates cellular uptake and metabolism of fuels, while the activated IGFR promotes cell growth, survival, and differentiation. Knockout mice studies have revealed the IGF-I receptor mediates IGF-I and IGF-II action on prenatal growth as well as IGF-I action on postnatal growth. The IR mediates prenatal growth in response to IGF-II and postnatal growth in response to insulin. All of these receptors share extensive structural homology and utilize the same downstream signalling cascades, one of which is illustrated here. Thus, how specificity is achieved in physiological outputs remains unclear, although it is thought to occur, in part, by differences in the locations and levels of receptor expression. Medline=11737239 Medline=11739335 Medline=11897402 Medline=12169433 Medline=12175645 Medline=12360255 PMID: 11737239 PMID: 11739335 PMID: 11897402 PMID: 12169433 PMID: 12175645 PMID: 12360255

PARTICIPANT STOICHIOMETRY r1 263
type: Stoichiometry
physical entity: INSR IGF-R IRR
stoichiometric coefficient: 1.0

uniprot O54857 211
type: UnificationXref
id: O54857
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7DUD6 197
xref: PTHR10048:SF107
organism: Ornithorhynchus anatinus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: DnaReference
xref: PTHR10048:SF107
organism: Rattus norvegicus

uniprot P08069 37
type: UnificationXref
id: P08069
db: uniprot

PARTICIPANT STOICHIOMETRY r1 264
type: Stoichiometry
physical entity: Insulin IGF
stoichiometric coefficient: 1.0

Tsc1
type: Protein
entity reference: Tsc1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P32871 200
type: UnificationXref
id: P32871
db: uniprot

Insulin IGF
type: ProteinReference
xref: P00896
standard name: Insulin/Insulin like growth factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.Insulin_br_IGF
comment: ENTITY_REFERENCE_NOTES=Long Name: Insulin/Insulin like growth factor Synonym: IGF,IGF1,IGF2,Insulin like growth factor 1,Insulin like growth factor 2 Accession: P00896
member entity reference: Insulin
member entity reference: Insulin-like growth factor I
member entity reference: Insulin-like growth factor II
member entity reference: Insulin-2
member entity reference: Insulin-like growth factor 2a
member entity reference: Insulin-like growth factor 2
member entity reference: Insulin-like growth factor 1
member entity reference: Insulin like growth factor 1
member entity reference: Insulin-1
member entity reference: Uncharacterized protein
member entity reference: IGF1 isoform 4

uniprot A0A2I3RGP6 126
type: UnificationXref
id: A0A2I3RGP6
db: uniprot

Insulin-like growth factor 2
type: ProteinReference
xref: uniprot Q8JIE4 80
xref: PTHR46886:SF1
organism: Danio rerio

FKHR
type: Protein
entity reference: FKHR
feature: FKHR s38 a66 rs1
feature: FKHR s38 a66 rs2
feature: ACTIVE 4
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Hamartin
type: ProteinReference
xref: PTHR15154:SF2
xref: uniprot Q9EP53 129
organism: Mus musculus

STATE_TRANSITION_LEFT__ATP-_FKHR-RIGHT__FKHR-_ADP-_r26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 271
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 270
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 268
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 269
left: ATP
left: FKHR
interaction type: STATE_TRANSITION
right: ADP
right: FKHR

Uncharacterized protein
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot F6VBA7 207
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re22 266
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PDK1_2-RIGHT__PDK1_2-_r21
controller: PiP3

Protein Mdm4
type: DnaReference
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_FKHR-RIGHT__FKHR-_ADP-_r26
controller: AKT

ncbitaxon 7955 6
type: UnificationXref
id: 7955
db: ncbitaxon

E3 ubiquitin-protein ligase Mdm2
type: DnaReference
xref: PTHR13844:SF15
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re22 267
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GSK_3-_ATP-RIGHT__ADP-_GSK_3-_r24
controller: AKT

uniprot F6V1C3 58
type: UnificationXref
id: F6V1C3
db: uniprot

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: uniprot H9FUJ1 138
xref: PTHR13844:SF15
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PiP3-RIGHT__PiP2-_r20
controller: PTEN

uniprot O35618 140
type: UnificationXref
id: O35618
db: uniprot

PiP3
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A1D5Q071 82
type: UnificationXref
id: A0A1D5Q071
db: uniprot

Si:dkeyp-80c12.7
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot B8JIQ1 150
organism: Danio rerio

uniprot Q9Z136 130
type: UnificationXref
id: Q9Z136
db: uniprot

PTHR24356:SF163
type: RelationshipXref
id: PTHR24356:SF163
db: PANTHER Family
relationship type: By Homology

p53
type: Protein
feature: ser, thr p53 s56 a84 rs2
feature: lys p53 s56 a84 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P14616 43
type: UnificationXref
id: P14616
db: uniprot

Forkhead box protein O3
type: ProteinReference
xref: uniprot O43524 96
xref: PTHR45767:SF4
organism: Homo sapiens

Protein Mdm4
type: ProteinReference
xref: uniprot O15151 139
organism: Homo sapiens

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot P60484 214
xref: PTHR12305:SF81
organism: Homo sapiens

uniprot A0A0G2JVC1 131
type: UnificationXref
id: A0A0G2JVC1
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot P60483 213
organism: Canis lupus familiaris

uniprot F7DUD6 197
type: UnificationXref
id: F7DUD6
db: uniprot

Insulin receptor substrate 1
type: ProteinReference
xref: uniprot E2RDB5 104
xref: PTHR10614:SF11
organism: Canis lupus familiaris

uniprot H2R1U8 121
type: UnificationXref
id: H2R1U8
db: uniprot

uniprot Q9Z2A0 189
type: UnificationXref
id: Q9Z2A0
db: uniprot

PTHR24057:SF0
type: RelationshipXref
id: PTHR24057:SF0
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot A0A1D5P7X1 9
organism: Gallus gallus

ncbitaxon 13616 29
type: UnificationXref
id: 13616
db: ncbitaxon

PTHR24057:SF8
type: RelationshipXref
id: PTHR24057:SF8
db: PANTHER Family
relationship type: By Homology

P110alpha
type: ProteinReference
xref: P04498
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.P110_alpha_
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: P110alpha Synonym: P110-alpha,PIK3CA Accession: P04498
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit

PARTICIPANT STOICHIOMETRY r21 242
type: Stoichiometry
physical entity: PDK1/2
stoichiometric coefficient: 1.0

uniprot Q03306 178
type: UnificationXref
id: Q03306
db: uniprot

PARTICIPANT STOICHIOMETRY r21 243
type: Stoichiometry
physical entity: PDK1/2
stoichiometric coefficient: 1.0

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot B0R0Q2 16
xref: PTHR24416:SF106
organism: Danio rerio

STATE_TRANSITION_LEFT__PDK1_2-RIGHT__PDK1_2-_r21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 242
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 243
left: PDK1/2
interaction type: STATE_TRANSITION
right: PDK1/2

uniprot A0A2I3RE00 132
type: UnificationXref
id: A0A2I3RE00
db: uniprot

By Homology
type: RelationshipTypeVocabulary

Insulin receptor-related protein
type: ProteinReference
xref: PTHR24416:SF338
xref: uniprot P14616 43
organism: Homo sapiens

uniprot P35569 112
type: UnificationXref
id: P35569
db: uniprot

uniprot Q8RUE8 184
type: UnificationXref
id: Q8RUE8
db: uniprot

PTHR46051:SF2
type: RelationshipXref
id: PTHR46051:SF2
db: PANTHER Family
relationship type: By Homology

ncbitaxon 10090 46
type: UnificationXref
id: 10090
db: ncbitaxon

Putative tyrosine-protein phosphatase TPTE
type: ProteinReference
xref: uniprot P56180 212
organism: Homo sapiens

Protein Mdm4
type: ProteinReference
xref: uniprot H2R875 137
organism: Pan troglodytes

Bos taurus
type: BioSource
xref: ncbitaxon 9913 23

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
name: Uncharacterized protein
xref: PTHR12305:SF81
organism: Canis lupus familiaris

GSK 3 s39 a65 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Tsc2 s12 sa6 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 12

uniprot F6RDI1 27
type: UnificationXref
id: F6RDI1
db: uniprot

00696
type: UnificationXref
id: MOD:00696
db: mod

TRANSLATION
type: InteractionVocabulary

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 56

IP16020p
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot Q7KMQ6 215
organism: Drosophila melanogaster

Insulin receptor substrate 4
type: ProteinReference
xref: uniprot F6YCQ0 106
xref: PTHR10614:SF2
organism: Xenopus tropicalis

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Canis lupus familiaris

Complex (Tsc2/Tsc1)
type: Complex
component stoichiometry: Tsc1 s14 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: Tsc2 s13 sa7 STOICHIOMETRY ID COMPLEX
component: Tsc1
component: Tsc2
feature: COMPLEX BINDING FEATURE s71 a110 229
feature: COMPLEX BINDING FEATURE s71 a110 227
cellular location: cytosol

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: uniprot Q9W0V1 186
xref: PTHR24356:SF163
organism: Drosophila melanogaster

ADP
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Forkhead box protein O1
type: ProteinReference
xref: uniprot Q9R1E0 100
organism: Mus musculus

uniprot F7GQ86 136
type: UnificationXref
id: F7GQ86
db: uniprot

uniprot Q8JIE4 80
type: UnificationXref
id: Q8JIE4
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1
type: ProteinReference
xref: uniprot Q9FLZ5 217
organism: Arabidopsis thaliana

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: DnaReference
xref: PTHR10048:SF107
organism: Homo sapiens

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot B1H2U0 204
xref: PTHR12305:SF81
organism: Xenopus tropicalis

3-phosphoinositide dependent protein kinase 1
type: ProteinReference
xref: uniprot F1Q2Y3 175
xref: PTHR24356:SF163
organism: Canis lupus familiaris

Hamartin
type: ProteinReference
xref: PTHR15154:SF2
xref: uniprot Q9Z136 130
organism: Rattus norvegicus

p110alpha
type: DnaRegion
entity reference: p110alpha
cellular location: cytosol
comment: SPECIES_TYPE=GENE

uniprot P67970 78
type: UnificationXref
id: P67970
db: uniprot

PTHR24416:SF535
type: RelationshipXref
id: PTHR24416:SF535
db: PANTHER Family
relationship type: By Homology

Protein Mdm4
type: DnaReference
organism: Canis lupus familiaris

FKHR s41 a61 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.7558272635422503
comment: MODIFICATION_RESIDUE_NAME=

Cation-independent mannose-6-phosphate receptor
type: ProteinReference
xref: uniprot P11717 42
xref: PTHR15071:SF17
organism: Homo sapiens

uniprot F6QUB0 57
type: UnificationXref
id: F6QUB0
db: uniprot

Serine/threonine-protein kinase ksg1
type: ProteinReference
xref: uniprot Q12701 182
xref: PTHR24356:SF163
organism: Schizosaccharomyces pombe

Inositol polyphosphate phosphatase like 1
type: ProteinReference
xref: uniprot F1PNY0 84
xref: PTHR46051:SF2
organism: Canis lupus familiaris

uniprot F1MV64 24
type: UnificationXref
id: F1MV64
db: uniprot

DISSOCIATION
type: RelationshipTypeVocabulary

Protein kinase gsk3
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot V5ILY7 172
organism: Neurospora crassa

TSC complex subunit 1
type: ProteinReference
xref: PTHR15154:SF2
xref: uniprot A0A2I3RGP6 126
organism: Pan troglodytes

STATE_TRANSITION_LEFT__GSK_3-_ATP-RIGHT__ADP-_GSK_3-_r24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 274
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 273
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 275
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 272
left: ATP
left: GSK-3
interaction type: STATE_TRANSITION
right: ADP
right: GSK-3

PTHR15071:SF17
type: RelationshipXref
id: PTHR15071:SF17
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot E2RPM8 21
xref: PTHR24416:SF535
organism: Canis lupus familiaris

Insulin receptor
type: ProteinReference
xref: uniprot P15208 45
xref: PTHR24416:SF535
organism: Mus musculus

Insulin receptor substrate 2
type: ProteinReference
xref: uniprot Q9Y4H2 115
xref: PTHR10614:SF7
organism: Homo sapiens

lys p53 s50 a77 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY lys
feature location: lys p53 s50 a77 rs1 lys
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.47684888491987926
comment: MODIFICATION_RESIDUE_NAME=lys

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 20

TRANSLATION_LEFT__Mdm2-RIGHT__Mdm2-_re39
type: TemplateReaction
product: Mdm2
xref: TRANSLATION
participant: Mdm2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

Uncharacterized protein
type: ProteinReference
xref: PTHR45767:SF4
xref: uniprot F1N4K5 90
organism: Bos taurus

ncbitaxon 9913 23
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot P56180 212
type: UnificationXref
id: P56180
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 10

PTHR13844:SF15
type: RelationshipXref
id: PTHR13844:SF15
db: PANTHER Family
relationship type: By Homology

Insulin-like growth factor 1 receptor
type: ProteinReference
xref: PTHR24416:SF106
xref: uniprot Q60751 49
organism: Mus musculus

uniprot E2R795 19
type: UnificationXref
id: E2R795
db: uniprot

Tsc2
type: Protein
entity reference: Tsc2
feature: Tsc2 s12 sa6 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa6 234
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P08025 73
type: UnificationXref
id: P08025
db: uniprot

uniprot P01325 65
type: UnificationXref
id: P01325
db: uniprot

Glycogen synthase kinase 3 alpha
type: ProteinReference
xref: uniprot Q9YH61 171
xref: PTHR24057:SF14
organism: Danio rerio

PTHR46886:SF1
type: RelationshipXref
id: PTHR46886:SF1
db: PANTHER Family
relationship type: By Homology

Glycogen synthase kinase 3
type: ProteinReference
xref: uniprot Q9YH60 170
xref: PTHR24057:SF8
organism: Danio rerio

uniprot Q9VK37 168
type: UnificationXref
id: Q9VK37
db: uniprot

uniprot F1Q054 119
type: UnificationXref
id: F1Q054
db: uniprot

uniprot Q9URT9 166
type: UnificationXref
id: Q9URT9
db: uniprot

Insulin-like growth factor 2a
type: ProteinReference
xref: uniprot Q5U3B4 79
xref: PTHR46886:SF1
organism: Danio rerio

PARTICIPANT STOICHIOMETRY re38 241
type: Stoichiometry
physical entity: Tsc1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re38 240
type: Stoichiometry
physical entity: Tsc2
stoichiometric coefficient: 1.0

IDA
type: EvidenceCodeVocabulary

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Glycogen synthesis
controller: GSK-3

STATE_TRANSITION
type: RelationshipTypeVocabulary

Uncharacterized protein
type: ProteinReference
xref: PTHR10614:SF11
xref: uniprot A0A1D5QB09 102
organism: Macaca mulatta

Protein Mdm4
type: DnaReference
organism: Macaca mulatta

uniprot P18266 158
type: UnificationXref
id: P18266
db: uniprot

PARTICIPANT STOICHIOMETRY re38 239
type: Stoichiometry
physical entity: Complex (Tsc2/Tsc1)
stoichiometric coefficient: 1.0

Tyrosine-protein kinase receptor
type: ProteinReference
xref: PTHR24416:SF525
xref: uniprot C4A0B6 17
organism: Branchiostoma floridae

Insulin receptor
type: ProteinReference
xref: uniprot P15127 44
xref: PTHR24416:SF535
organism: Rattus norvegicus

PTHR24416:SF525
type: RelationshipXref
id: PTHR24416:SF525
db: PANTHER Family
relationship type: By Homology

TRANSLATION_LEFT__PTEN-RIGHT__PTEN-_re41
type: TemplateReaction
product: PTEN
xref: TRANSLATION
participant: PTEN
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

uniprot F7DE94 107
type: UnificationXref
id: F7DE94
db: uniprot

Insulin receptor substrate 4
type: ProteinReference
xref: PTHR10614:SF2
xref: uniprot Q9Z0Y7 116
organism: Mus musculus

Tuberin
type: ProteinReference
xref: uniprot P49815 122
xref: PTHR10063:SF0
organism: Homo sapiens

Tuberin
type: ProteinReference
xref: PTHR10063:SF0
xref: uniprot P49816 123
organism: Rattus norvegicus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cell survival maintenance
controller: FKHR

PTEN
type: DnaRegion
entity reference: phospatase and tensin homologue
cellular location: cytosol
comment: SPECIES_TYPE=GENE

uniprot O42354 141
type: UnificationXref
id: O42354
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: DnaReference
xref: PTHR10048:SF107
organism: Bos taurus

FOXO1 isoform 1
type: ProteinReference
xref: uniprot H2Q7G4 94
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AKT-_ATP-RIGHT__ADP-_AKT-_r22
controller: PDK1/2

uniprot A5PJB2 54
type: UnificationXref
id: A5PJB2
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot A0A2I3TNH3 203
xref: PTHR12305:SF81
organism: Pan troglodytes

P53 pathway
type: Pathway

uniprot F6Y6G0 127
type: UnificationXref
id: F6Y6G0
db: uniprot

uniprot H9FUJ1 138
type: UnificationXref
id: H9FUJ1
db: uniprot

Tsc2 s13 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Tsc2
stoichiometric coefficient: 1.0

uniprot F6ZVZ0 92
type: UnificationXref
id: F6ZVZ0
db: uniprot

Cell growth low ROS high HSP
type: Pathway

uniprot H2QJJ4 108
type: UnificationXref
id: H2QJJ4
db: uniprot

TSC complex subunit 2
type: ProteinReference
xref: PTHR10063:SF0
xref: uniprot E1BNT2 118
organism: Bos taurus

TRANSLATION_LEFT__p110alpha-RIGHT__P110alpha-_re40
type: TemplateReaction
product: P110alpha
xref: TRANSLATION
participant: P110alpha
participant: p110alpha
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot H2QA49 33
xref: PTHR24416:SF106
organism: Pan troglodytes

INSR IGF-R IRR
type: ProteinReference
xref: P00895
standard name: Insulin receptor/Insulin like growth factor receptor/insulin related receptor
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.RECEPTOR.INSR_br_IGF_minus_R_br_IRR
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
comment: ENTITY_REFERENCE_NOTES=Long Name: Insulin receptor/Insulin like growth factor receptor/insulin related receptor Synonym: IGF-R,IGF-R1,IGF-R2,INSR,IRR,Insulin R,Insulin like growth factor receptor 1,Insulin like growth factor receptor 2 Accession: P00895
member entity reference: Tyrosine-protein kinase receptor
member entity reference: Uncharacterized protein
member entity reference: Insulin receptor-related protein
member entity reference: Insulin receptor
member entity reference: Insulin-like growth factor 1 receptor
member entity reference: Insulin-like growth factor 2 receptor
member entity reference: Cation-independent mannose-6-phosphate receptor
member entity reference: Insulin-like receptor
member entity reference: Insulin like growth factor 2 receptor

IRS 1 4 s22 a8 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

TSC complex subunit 2
type: ProteinReference
xref: uniprot F1Q054 119
xref: PTHR10063:SF0
organism: Canis lupus familiaris

uniprot P09535 74
type: UnificationXref
id: P09535
db: uniprot

uniprot P15208 45
type: UnificationXref
id: P15208
db: uniprot

Insulin-like growth factor 2 receptor
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot G3V824 31
organism: Rattus norvegicus

uniprot F1Q2Y3 175
type: UnificationXref
id: F1Q2Y3
db: uniprot

Tyrosine-protein kinase receptor
type: ProteinReference
xref: PTHR24416:SF338
xref: uniprot F1MC23 22
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5F3U4 183
xref: PTHR24356:SF163
organism: Gallus gallus

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 149

PKB s37 a57 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 164

PTHR10063:SF0
type: RelationshipXref
id: PTHR10063:SF0
db: PANTHER Family
relationship type: By Homology

Insulin like growth factor 1
type: ProteinReference
xref: uniprot F6PZT8 55
organism: Ornithorhynchus anatinus

TRANSCRIPTION_LEFT__p110alpha-RIGHT__p110alpha-_re42
type: TemplateReaction
product: p110alpha
xref: TRANSCRIPTION
participant: p110alpha
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

GSK-3
type: Protein
entity reference: GSK-3
feature: GSK 3 s39 a65 rs1
feature: ACTIVE 4
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P01308 61
type: UnificationXref
id: P01308
db: uniprot

Tsc2
type: Protein
entity reference: Tsc2
feature: Tsc2 s13 sa7 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa7 228
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

p53
type: Protein
feature: lys p53 s50 a77 rs1
feature: ser, thr p53 s50 a77 rs2
feature: ACTIVE 4
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P01322 63
type: UnificationXref
id: P01322
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6VXG1 196
xref: PTHR10048:SF107
organism: Xenopus tropicalis

Putative glycogen synthase kinase-3 homolog
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot P83101 161
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__IRS_1_4-_ATP-RIGHT__IRS_1_4-_ADP-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 262
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 260
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 259
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 261
left: ATP
left: IRS 1-4
interaction type: STATE_TRANSITION
right: IRS 1-4
right: ADP

uniprot Q9FLZ5 217
type: UnificationXref
id: Q9FLZ5
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A0G2K5T3 192
organism: Rattus norvegicus

FKHR
type: Protein
entity reference: FKHR
feature: FKHR s41 a61 rs2
feature: FKHR s41 a61 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

FOXO3 isoform 1
type: ProteinReference
xref: PTHR45767:SF4
xref: uniprot H2R710 95
organism: Pan troglodytes

Forkhead box protein O1
type: ProteinReference
xref: uniprot G3V7R4 93
organism: Rattus norvegicus

uniprot F6VZY3 59
type: UnificationXref
id: F6VZY3
db: uniprot

uniprot P42337 202
type: UnificationXref
id: P42337
db: uniprot

uniprot F1N736 135
type: UnificationXref
id: F1N736
db: uniprot

uniprot Q9W0V1 186
type: UnificationXref
id: Q9W0V1
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 185

Protein Mdm4
type: ProteinReference
xref: uniprot O35618 140
organism: Mus musculus

ser, thr p53 s56 a84 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY ser, thr
feature location: ser, thr p53 s56 a84 rs2 ser, thr
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.7201913134280393
comment: MODIFICATION_RESIDUE_NAME=ser, thr

ser, thr p53 s50 a77 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY ser, thr
feature location: ser, thr p53 s50 a77 rs2 ser, thr
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.7201913134280393
comment: MODIFICATION_RESIDUE_NAME=ser, thr

uniprot Q9U2Q9 165
type: UnificationXref
id: Q9U2Q9
db: uniprot

uniprot G5EE01 209
type: UnificationXref
id: G5EE01
db: uniprot

uniprot A0A0R4IGP2 5
type: UnificationXref
id: A0A0R4IGP2
db: uniprot

uniprot P49840 159
type: UnificationXref
id: P49840
db: uniprot

PARTICIPANT STOICHIOMETRY r2 262
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q9WV60 169
type: UnificationXref
id: Q9WV60
db: uniprot

STATE_TRANSITION_LEFT__AKT-_ATP-RIGHT__ADP-_AKT-_r22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 236
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 235
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 237
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 238
left: ATP
left: AKT
interaction type: STATE_TRANSITION
right: AKT
right: ADP

Mdm2
type: RnaRegion
cellular location: cytosol
comment: SPECIES_TYPE=RNA

Mdm2
type: ProteinReference
xref: P04496
standard name: Mouse double minute 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Mdm2 Synonym: Synonym not specified Accession: P04496 Pathway Link: P04398|P04663|p53 pathway feedback loops 2*P04392|P04536|P53 pathway feedback loops 1*P00059|P01483|p53 pathway
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.Mdm2
member entity reference: Protein Mdm4
member entity reference: E3 ubiquitin-protein ligase Mdm2
member entity reference: MDM2 proto-oncogene

uniprot P01323 64
type: UnificationXref
id: P01323
db: uniprot

Mdm2
type: Protein
entity reference: Mdm2
feature: Mdm2 s53 a80 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3RFV3 13
type: UnificationXref
id: A0A2I3RFV3
db: uniprot

Insulin receptor substrate 3
type: ProteinReference
xref: PTHR10614:SF8
xref: uniprot B1WBQ1 103
organism: Rattus norvegicus

uniprot P09208 40
type: UnificationXref
id: P09208
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P32871 200
organism: Bos taurus

uniprot P01321 62
type: UnificationXref
id: P01321
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

uniprot Q2NL51 162
type: UnificationXref
id: Q2NL51
db: uniprot

uniprot F6SJA3 28
type: UnificationXref
id: F6SJA3
db: uniprot

uniprot P18254 75
type: UnificationXref
id: P18254
db: uniprot

PI3-K
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa3 224
feature: ACTIVE 4
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r2 260
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 261
type: Stoichiometry
physical entity: IRS 1-4
stoichiometric coefficient: 1.0

PTHR12305:SF81
type: RelationshipXref
id: PTHR12305:SF81
db: PANTHER Family
relationship type: By Homology

Forkhead box O3
type: ProteinReference
xref: uniprot D3ZBQ1 89
xref: PTHR45767:SF4
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZVZ0 92
organism: Macaca mulatta

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot E2RB53 151
organism: Canis lupus familiaris

TRANSPORT_LEFT__FKHR-RIGHT__FKHR-_r30
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 253
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 252
left: FKHR
interaction type: TRANSPORT
right: FKHR

uniprot Q03407 180
type: UnificationXref
id: Q03407
db: uniprot

Tsc1 s11 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Tsc1
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__PTEN-RIGHT__PTEN-_re43
control type: ACTIVATION
controller: p53

PTEN
type: RnaRegion
cellular location: cytosol
comment: SPECIES_TYPE=RNA

Protein Mdm4
type: DnaReference
organism: Mus musculus

PDK1/2
type: Protein
entity reference: PDK1/2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PANTHER Pathway P00033 1
type: UnificationXref
id: P00033
db: PANTHER Pathway

Protein Mdm4
type: DnaReference
organism: Rattus norvegicus

Protein Mdm4
type: ProteinReference
xref: uniprot F7GQ86 136
organism: Macaca mulatta

P110alpha s10 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: P110alpha
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot Q93372 163
organism: Caenorhabditis elegans

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot A0A1D5R6B6 11
xref: PTHR24416:SF106
organism: Macaca mulatta

uniprot O55173 177
type: UnificationXref
id: O55173
db: uniprot

ncbitaxon 6239 164
type: UnificationXref
id: 6239
db: ncbitaxon

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__p110alpha-RIGHT__p110alpha-_re42
control type: INHIBITION
controller: p53

IGF1 isoform 4
type: ProteinReference
xref: uniprot A0A2I3RUB7 52
organism: Pan troglodytes

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: uniprot Q00987 143
xref: PTHR13844:SF15
organism: Homo sapiens

Forkhead box protein O
type: ProteinReference
xref: PTHR45767:SF2
xref: uniprot Q95V55 99
organism: Drosophila melanogaster

Insulin-like growth factor 2
type: ProteinReference
xref: uniprot F6QUB0 57
xref: PTHR46886:SF1
organism: Xenopus tropicalis

uniprot A0A3Q1LJI4 146
type: UnificationXref
id: A0A3Q1LJI4
db: uniprot

uniprot O73727 60
type: UnificationXref
id: O73727
db: uniprot

uniprot G3V824 31
type: UnificationXref
id: G3V824
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 18

uniprot Q92574 128
type: UnificationXref
id: Q92574
db: uniprot

IP16020p
type: DnaReference
xref: PTHR12305:SF81
organism: Drosophila melanogaster

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: P53 pathway
controller: p53

HETERODIMER_ASSOCIATION_LEFT__PI3_K-_P110alpha-RIGHT__Complex__PI3_K_P110alpha_-_re25
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 256
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 258
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 257
left: P110alpha
left: PI3-K
interaction type: HETERODIMER_ASSOCIATION
right: Complex (PI3-K/P110alpha)

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 7

uniprot F1MYE6 134
type: UnificationXref
id: F1MYE6
db: uniprot

Glycogen synthase kinase-3 beta isoform 1
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot H9EPM1 156
organism: Macaca mulatta

IRS 1-4
type: Protein
entity reference: IRS 1-4
feature: IRS 1 4 s7 a7 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SHIP2
type: Protein
entity reference: SHIP2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: p27 Apoptosis
controller: FKHR

Tyrosine-protein kinase receptor
type: ProteinReference
xref: PTHR24416:SF338
xref: uniprot E2R795 19
organism: Canis lupus familiaris

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__p53-RIGHT__s77-_re47
control type: ACTIVATION
controller: Mdm2

uniprot F6VXG1 196
type: UnificationXref
id: F6VXG1
db: uniprot

ncbitaxon 9544 12
type: UnificationXref
id: 9544
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR45767:SF4
xref: uniprot F6UMX8 91
organism: Macaca mulatta

uniprot P08169 39
type: UnificationXref
id: P08169
db: uniprot

Tsc2
type: ProteinReference
xref: P04494
standard name: Tuberous sclerosis 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Tuberin Synonym: Synonym not specified Accession: P04494
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.Tsc2
member entity reference: Tuberin
member entity reference: TSC complex subunit 2
member entity reference: Uncharacterized protein

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PGQ1 153
xref: PTHR24057:SF8
organism: Monodelphis domestica

IRS 1-4
type: ProteinReference
xref: P00899
standard name: Insulin receptor substrate family
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.IRS_space_1_minus_4
comment: ENTITY_REFERENCE_NOTES=Long Name: Insulin receptor substrate family Synonym: IRS Accession: P00899
member entity reference: Insulin receptor substrate 1
member entity reference: Insulin receptor substrate 3
member entity reference: Insulin receptor substrate 2
member entity reference: Insulin receptor substrate 4
member entity reference: Insulin receptor substrate 3, isoform CRA_a (Fragment)
member entity reference: Uncharacterized protein
member entity reference: IRS1 isoform 1

TSC complex subunit 2
type: ProteinReference
xref: uniprot H2R1U8 121
xref: PTHR10063:SF0
organism: Pan troglodytes

INPPL1 isoform 1
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot H2Q4C6 85
organism: Pan troglodytes

Mdm2
type: DnaRegion
entity reference: Mouse double minute 2
cellular location: cytosol
comment: SPECIES_TYPE=GENE

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Gallus gallus

p27 Apoptosis
type: Pathway

uniprot P49815 122
type: UnificationXref
id: P49815
db: uniprot

Protein Mdm4
type: ProteinReference
xref: uniprot F1N736 135
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r2 259
type: Stoichiometry
physical entity: IRS 1-4
stoichiometric coefficient: 1.0

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 29

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

Uncharacterized protein
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot F6RDI1 27
organism: Macaca mulatta

uniprot F1MDX9 205
type: UnificationXref
id: F1MDX9
db: uniprot

MDM2 proto-oncogene
type: DnaReference
xref: PTHR13844:SF15
organism: Pan troglodytes

E3 ubiquitin-protein ligase Mdm2
type: DnaReference
xref: PTHR13844:SF15
organism: Mus musculus

ncbitaxon 367110 173
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot Q7KMQ6 215
type: UnificationXref
id: Q7KMQ6
db: uniprot

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot A0A0R4IGP2 5
xref: PTHR24416:SF106
organism: Danio rerio

uniprot B1WBQ1 103
type: UnificationXref
id: B1WBQ1
db: uniprot

uniprot P35570 113
type: UnificationXref
id: P35570
db: uniprot

STATE_TRANSITION_LEFT__Complex__Tsc1_Tsc2_-RIGHT__Complex__Tsc2_Tsc1_-_re37
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 244
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 245
left: Complex (Tsc1/Tsc2)
interaction type: STATE_TRANSITION
right: Complex (Tsc2/Tsc1)

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: uniprot Q9Z2A0 189
xref: PTHR24356:SF163
organism: Mus musculus

Mouse double minute 2
type: DnaRegionReference
member entity reference: MDM2 proto-oncogene
member entity reference: Protein Mdm4
member entity reference: E3 ubiquitin-protein ligase Mdm2
xref: G04674
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.GENE.GENE.Mdm2
comment: ENTITY_REFERENCE_NOTES=Long Name: Mdm2 Synonym: Synonym not specified Accession: G04674
display name: Mdm2

Insulin-like growth factor I
type: ProteinReference
xref: uniprot P05019 70
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__INSR_IGF_R_IRR-_Insulin_IGF-RIGHT__Complex__Insulin_IGF_INSR_IGF_R_IRR_-_r1
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 264
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 263
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 265
left: INSR IGF-R IRR
left: Insulin IGF
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Insulin IGF/INSR IGF-R IRR)

PTEN
type: Protein
entity reference: PTEN
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: uniprot O15530 176
xref: PTHR24356:SF163
organism: Homo sapiens

Insulin-like growth factor I
type: ProteinReference
xref: uniprot P05017 69
organism: Mus musculus

uniprot A0A3Q2TVV5 147
type: UnificationXref
id: A0A3Q2TVV5
db: uniprot

G04675
type: UnificationXref
id: G04675
db: PANTHER Pathway Component

uniprot F6PGQ1 153
type: UnificationXref
id: F6PGQ1
db: uniprot

uniprot F6V748 120
type: UnificationXref
id: F6V748
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Rattus norvegicus

G04674
type: UnificationXref
id: G04674
db: PANTHER Pathway Component

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 167

G04676
type: UnificationXref
id: G04676
db: PANTHER Pathway Component

P00902
type: UnificationXref
id: P00902
db: PANTHER Pathway Component

uniprot F6SW23 195
type: UnificationXref
id: F6SW23
db: uniprot

Insulin-like growth factor 2 receptor
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot K7B5K7 34
organism: Pan troglodytes

P00905
type: UnificationXref
id: P00905
db: PANTHER Pathway Component

TRANSCRIPTION
type: InteractionVocabulary

lys p53 s56 a84 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY lys
feature location: lys p53 s56 a84 rs1 lys
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.47684888491987926
comment: MODIFICATION_RESIDUE_NAME=lys

P00903
type: UnificationXref
id: P00903
db: PANTHER Pathway Component

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7G3I5 198
xref: PTHR10048:SF107
organism: Monodelphis domestica

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: uniprot O55173 177
xref: PTHR24356:SF163
organism: Rattus norvegicus

Tsc2
type: Protein
entity reference: Tsc2
feature: Tsc2 s62 a106 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PDK1/2
type: ProteinReference
xref: P00903
standard name: 3-phosphoinositide-dependent protein kinase 1 and 2
comment: ENTITY_REFERENCE_NOTES=Long Name: 3-phosphoinositide-dependent protein kinase Synonym: Synonym not specified Accession: P00903
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.PDK1_slash_2
member entity reference: Serine/threonine-protein kinase PKH1
member entity reference: 3-phosphoinositide-dependent protein kinase 1
member entity reference: Serine/threonine-protein kinase PKH2
member entity reference: 3-phosphoinositide dependent protein kinase 1
member entity reference: Serine/threonine-protein kinase ksg1
member entity reference: Os01g0872800 protein
member entity reference: Serine/threonine-protein kinase PKH3
member entity reference: Uncharacterized protein

uniprot F6VBA7 207
type: UnificationXref
id: F6VBA7
db: uniprot

PTHR45767:SF4
type: RelationshipXref
id: PTHR45767:SF4
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot F1MV64 24
xref: PTHR24416:SF535
organism: Bos taurus

PTHR45767:SF2
type: RelationshipXref
id: PTHR45767:SF2
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9031 10
type: UnificationXref
id: 9031
db: ncbitaxon

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Mdm2-RIGHT__Mdm2-_re44
control type: ACTIVATION
controller: p53

Serine/threonine-protein kinase PKH3
type: ProteinReference
xref: uniprot Q03306 178
organism: Saccharomyces cerevisiae

uniprot Q9XF67 187
type: UnificationXref
id: Q9XF67
db: uniprot

DISSOCIATION
type: InteractionVocabulary

uniprot Q12778 97
type: UnificationXref
id: Q12778
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VZY3 59
organism: Macaca mulatta

FKHR s49 a76 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.7040297999055483

Uncharacterized protein
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot E1BBJ7 83
organism: Bos taurus

uniprot P06213 35
type: UnificationXref
id: P06213
db: uniprot

Hamartin
type: ProteinReference
xref: uniprot Q92574 128
xref: PTHR15154:SF2
organism: Homo sapiens

Insulin-like growth factor 1
type: ProteinReference
xref: uniprot F6V1C3 58
organism: Xenopus tropicalis

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot A0A2I3SXI2 145
organism: Pan troglodytes

Tsc2 s12 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Tsc2
stoichiometric coefficient: 1.0

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Gallus gallus

uniprot P49841 160
type: UnificationXref
id: P49841
db: uniprot

Insulin-like growth factor II
type: ProteinReference
xref: PTHR46886:SF1
xref: uniprot P01346 68
organism: Rattus norvegicus

Insulin-like growth factor II
type: ProteinReference
xref: uniprot P01344 67
xref: PTHR46886:SF1
organism: Homo sapiens

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: uniprot Q9WV60 169
xref: PTHR24057:SF8
organism: Mus musculus

uniprot P15127 44
type: UnificationXref
id: P15127
db: uniprot

uniprot Q5U3B4 79
type: UnificationXref
id: Q5U3B4
db: uniprot

uniprot Q00987 143
type: UnificationXref
id: Q00987
db: uniprot

IRS 1-4
type: Protein
entity reference: IRS 1-4
feature: ACTIVE 4
feature: IRS 1 4 s22 a8 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 36

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
organism: Danio rerio

PDK1/2
type: Protein
entity reference: PDK1/2
feature: ACTIVE 4
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

FKHR s49 a76 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.7558272635422503
comment: MODIFICATION_RESIDUE_NAME=

PKB s35 a53 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: P53 pathway
controller: Mdm2

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 188

STATE_TRANSITION_LEFT__PiP3-RIGHT__PiP2-_r20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 247
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 246
left: PiP3
interaction type: STATE_TRANSITION
right: PiP2

ncbitaxon 9258 56
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot Q07113 48
type: UnificationXref
id: Q07113
db: uniprot

E3 ubiquitin-protein ligase Mdm2
type: DnaReference
xref: PTHR13844:SF15
organism: Macaca mulatta

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: uniprot P18266 158
xref: PTHR24057:SF8
organism: Rattus norvegicus

Glycogen synthase kinase-3 alpha
type: ProteinReference
xref: uniprot P18265 157
xref: PTHR24057:SF14
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r24 274
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 273
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 272
type: Stoichiometry
physical entity: GSK-3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 275
type: Stoichiometry
physical entity: GSK-3
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR15154:SF2
xref: uniprot F6Y6G0 127
organism: Macaca mulatta

Serine/threonine-protein kinase PKH1
type: ProteinReference
xref: PTHR24356:SF368
xref: uniprot Q03407 180
organism: Saccharomyces cerevisiae

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot F6QWD3 25
xref: PTHR24416:SF106
organism: Xenopus tropicalis

P00899
type: UnificationXref
id: P00899
db: PANTHER Pathway Component

uniprot F6SWY2 30
type: UnificationXref
id: F6SWY2
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Pan troglodytes

P00895
type: UnificationXref
id: P00895
db: PANTHER Pathway Component

P00896
type: UnificationXref
id: P00896
db: PANTHER Pathway Component

Danio rerio
type: BioSource
xref: ncbitaxon 7955 6

P00897
type: UnificationXref
id: P00897
db: PANTHER Pathway Component

P00898
type: UnificationXref
id: P00898
db: PANTHER Pathway Component

uniprot P42336 201
type: UnificationXref
id: P42336
db: uniprot

Insulin
type: ProteinReference
xref: uniprot P01321 62
organism: Canis lupus familiaris

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A
type: DnaReference
name: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1
organism: Arabidopsis thaliana

Serine/threonine-protein kinase PKH2
type: ProteinReference
xref: PTHR24356:SF368
xref: uniprot Q12236 181
organism: Saccharomyces cerevisiae

Insulin-1
type: ProteinReference
xref: uniprot P01322 63
organism: Rattus norvegicus

uniprot D3ZBQ1 89
type: UnificationXref
id: D3ZBQ1
db: uniprot

Insulin-1
type: ProteinReference
xref: uniprot P01325 65
organism: Mus musculus

PTHR24057:SF14
type: RelationshipXref
id: PTHR24057:SF14
db: PANTHER Family
relationship type: By Homology

Insulin-2
type: ProteinReference
xref: uniprot P01326 66
organism: Mus musculus

Insulin-2
type: ProteinReference
xref: uniprot P01323 64
organism: Rattus norvegicus

uniprot O54718 110
type: UnificationXref
id: O54718
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Monodelphis domestica

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: PTHR13844:SF15
xref: uniprot A0A0G2JVC1 131
organism: Rattus norvegicus

uniprot P35568 111
type: UnificationXref
id: P35568
db: uniprot

uniprot O14654 109
type: UnificationXref
id: O14654
db: uniprot

Insulin-like growth factor I
type: ProteinReference
xref: uniprot P18254 75
organism: Gallus gallus

Insulin
type: ProteinReference
xref: uniprot A5PJB2 54
organism: Bos taurus

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot O15357 86
organism: Homo sapiens

Mdm2 s54 a81 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PiP3-RIGHT__PiP2-_r20
controller: SHIP2

uniprot P01326 66
type: UnificationXref
id: P01326
db: uniprot

FKHR s38 a66 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.7040297999055483

uniprot Q64716 50
type: UnificationXref
id: Q64716
db: uniprot

uniprot E2RDB5 104
type: UnificationXref
id: E2RDB5
db: uniprot

PARTICIPANT STOICHIOMETRY re47 251
type: Stoichiometry
physical entity: s77
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re47 250
type: Stoichiometry
physical entity: p53
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__p53-RIGHT__s77-_re47
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re47 251
participant stoichiometry: PARTICIPANT STOICHIOMETRY re47 250
left: p53
interaction type: STATE_TRANSITION
right: s77

GSK-3
type: ProteinReference
xref: P00902
standard name: Glycogen synthase kinase 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.GSK_minus_3
comment: ENTITY_REFERENCE_NOTES=Long Name: Glycogen synthase kinase 3 Synonym: Synonym not specified Accession: P00902
member entity reference: Uncharacterized protein
member entity reference: Glycogen synthase kinase-3 beta
member entity reference: Glycogen synthase kinase-3
member entity reference: Glycogen synthase kinase-3 alpha
member entity reference: Protein kinase gsk3
member entity reference: Protein CBG07560
member entity reference: Glycogen synthase kinase 3 beta
member entity reference: Protein kinase gsk31
member entity reference: Glycogen synthase kinase 3 alpha
member entity reference: Si:dkeyp-80c12.7
member entity reference: Glycogen synthase kinase 3
member entity reference: Pk34A
member entity reference: Putative glycogen synthase kinase-3 homolog
member entity reference: Glycogen synthase kinase-3 beta isoform 1

FKHR
type: ProteinReference
xref: P00898
standard name: Forkhead transcription factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Forkhead transcription factor Synonym: FOXO1A,Forkhead box O1A,Forkhead in rhabdomyosarcoma Accession: P00898
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.FKHR
member entity reference: Forkhead box protein O1
member entity reference: Uncharacterized protein
member entity reference: Forkhead box protein O3
member entity reference: Forkhead box O3
member entity reference: Forkhead box O3b
member entity reference: FOXO3 isoform 1
member entity reference: Forkhead box protein O
member entity reference: FOXO1 isoform 1

uniprot Q9Z0Y7 116
type: UnificationXref
id: Q9Z0Y7
db: uniprot

PTHR24416:SF338
type: RelationshipXref
id: PTHR24416:SF338
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF14
xref: uniprot F1PAE3 152
organism: Canis lupus familiaris

uniprot A0A1D5R6B6 11
type: UnificationXref
id: A0A1D5R6B6
db: uniprot

DISSOCIATION_LEFT__Complex__Tsc2_Tsc1_-RIGHT__Tsc2-_Tsc1-_re38
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 241
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 240
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 239
left: Complex (Tsc2/Tsc1)
interaction type: DISSOCIATION
right: Tsc1
right: Tsc2

Insulin-like growth factor 1 receptor
type: ProteinReference
xref: uniprot P24062 47
xref: PTHR24416:SF106
organism: Rattus norvegicus

uniprot Q9XTN2 114
type: UnificationXref
id: Q9XTN2
db: uniprot

uniprot A0A0G2K344 191
type: UnificationXref
id: A0A0G2K344
db: uniprot

Protein Mdm4
type: ProteinReference
xref: uniprot E2RDT3 133
organism: Canis lupus familiaris

TRANSCRIPTION
type: RelationshipTypeVocabulary

Insulin receptor
type: ProteinReference
xref: uniprot P06213 35
xref: PTHR24416:SF535
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Tsc1_Tsc2_-RIGHT__Complex__Tsc2_Tsc1_-_re37
controller: AKT

Insulin
type: ProteinReference
xref: uniprot P01308 61
organism: Homo sapiens

uniprot F6QWD3 25
type: UnificationXref
id: F6QWD3
db: uniprot

Protein CBG07560
type: ProteinReference
xref: uniprot A8X4K1 148
organism: Caenorhabditis briggsae

Uncharacterized protein
type: ProteinReference
xref: uniprot F6V748 120
xref: PTHR10063:SF0
organism: Macaca mulatta

uniprot Q9WVH4 101
type: UnificationXref
id: Q9WVH4
db: uniprot

Protein Mdm4
type: DnaReference
organism: Pan troglodytes

uniprot A0A2I3T7A8 193
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

uniprot F6UMX8 91
type: UnificationXref
id: F6UMX8
db: uniprot

uniprot A0A1D5QB09 102
type: UnificationXref
id: A0A1D5QB09
db: uniprot

uniprot P18265 157
type: UnificationXref
id: P18265
db: uniprot

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 190

uniprot A0A2I3S4A3 15
type: UnificationXref
id: A0A2I3S4A3
db: uniprot

FKHR s38 a66 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.7558272635422503
comment: MODIFICATION_RESIDUE_NAME=

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Glycogen synthase kinase-3 alpha
type: ProteinReference
xref: PTHR24057:SF14
xref: uniprot Q2NL51 162
organism: Mus musculus

P110alpha
type: Protein
entity reference: P110alpha
feature: ACTIVE 4
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q60751 49
type: UnificationXref
id: Q60751
db: uniprot

Mdm2 s53 a80 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
organism: Dictyostelium discoideum

uniprot O43524 96
type: UnificationXref
id: O43524
db: uniprot

uniprot A0A2I3TNH3 203
type: UnificationXref
id: A0A2I3TNH3
db: uniprot

PTHR10614:SF2
type: RelationshipXref
id: PTHR10614:SF2
db: PANTHER Family
relationship type: By Homology

ncbitaxon 6238 149
type: UnificationXref
id: 6238
db: ncbitaxon

PTHR10614:SF7
type: RelationshipXref
id: PTHR10614:SF7
db: PANTHER Family
relationship type: By Homology

PTHR10614:SF8
type: RelationshipXref
id: PTHR10614:SF8
db: PANTHER Family
relationship type: By Homology

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 38

uniprot O08586 210
type: UnificationXref
id: O08586
db: uniprot

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

uniprot A8X4K1 148
type: UnificationXref
id: A8X4K1
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR12305:SF81
organism: Macaca mulatta

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Macaca mulatta

MCG118205, isoform CRA_c
type: DnaReference
organism: Mus musculus

uniprot Q5TYS1 98
type: UnificationXref
id: Q5TYS1
db: uniprot

uniprot H9FVU5 199
type: UnificationXref
id: H9FVU5
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Rattus norvegicus

Complex (Insulin IGF/INSR IGF-R IRR)
type: Complex
component stoichiometry: Insulin IGF s3 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: INSR IGF R IRR s4 sa2 STOICHIOMETRY ID COMPLEX
component: Insulin IGF
component: INSR IGF-R IRR
feature: COMPLEX BINDING FEATURE s5 a5 219
feature: COMPLEX BINDING FEATURE s5 a5 221
cellular location: cytosol

uniprot Q93372 163
type: UnificationXref
id: Q93372
db: uniprot

PI3 K s6 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PI3-K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r26 268
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot Q12701 182
type: UnificationXref
id: Q12701
db: uniprot

PARTICIPANT STOICHIOMETRY r26 269
type: Stoichiometry
physical entity: FKHR
stoichiometric coefficient: 1.0

Pk34A
type: ProteinReference
xref: uniprot Q9VK37 168
organism: Drosophila melanogaster

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 32

uniprot H2R710 95
type: UnificationXref
id: H2R710
db: uniprot

Insulin-like growth factor 1
type: ProteinReference
xref: uniprot Q90VV9 81
organism: Danio rerio

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
type: DnaReference
xref: PTHR12305:SF81
organism: Caenorhabditis elegans

Insulin-like receptor
type: ProteinReference
xref: PTHR24416:SF525
xref: uniprot P09208 40
organism: Drosophila melanogaster

uniprot P01346 68
type: UnificationXref
id: P01346
db: uniprot

MCG118205, isoform CRA_c
type: ProteinReference
xref: uniprot G5E8H5 208
organism: Mus musculus

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

INHIBITION
type: RelationshipTypeVocabulary

uniprot Q5XIN1 144
type: UnificationXref
id: Q5XIN1
db: uniprot

Complex (Tsc1/Tsc2)
type: Complex
component stoichiometry: Tsc2 s12 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: Tsc1 s11 sa5 STOICHIOMETRY ID COMPLEX
component: Tsc1
component: Tsc2
feature: COMPLEX BINDING FEATURE s68 a104 233
feature: COMPLEX BINDING FEATURE s68 a104 231
feature: ACTIVE 4
cellular location: cytosol

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: DnaReference
xref: PTHR12305:SF81
organism: Xenopus tropicalis

FKHR
type: Protein
entity reference: FKHR
feature: FKHR s49 a76 rs1
feature: FKHR s49 a76 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r22 237
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 238
type: Stoichiometry
physical entity: AKT
stoichiometric coefficient: 1.0

eco ECO:0000304 38
type: UnificationXref
id: ECO:0000304
db: eco

uniprot A0A1D5P7X1 9
type: UnificationXref
id: A0A1D5P7X1
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: DnaReference
xref: PTHR10048:SF107
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r22 235
type: Stoichiometry
physical entity: AKT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 236
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot A0A2I3SXI2 145
type: UnificationXref
id: A0A2I3SXI2
db: uniprot

ncbitaxon 7739 18
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot B1H2U0 204
type: UnificationXref
id: B1H2U0
db: uniprot

uniprot P07455 71
type: UnificationXref
id: P07455
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot G5EE01 209
organism: Caenorhabditis elegans

Insulin
type: ProteinReference
xref: uniprot P67970 78
organism: Gallus gallus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cell growth low ROS high HSP
controller: FKHR

uniprot F1PNY0 84
type: UnificationXref
id: F1PNY0
db: uniprot

uniprot P05017 69
type: UnificationXref
id: P05017
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re19
controller: AKT

p110alpha
type: RnaRegion
cellular location: cytosol
comment: SPECIES_TYPE=RNA

Insulin receptor substrate 2
type: ProteinReference
xref: uniprot F7DE94 107
xref: PTHR10614:SF7
organism: Macaca mulatta

uniprot F1NT98 206
type: UnificationXref
id: F1NT98
db: uniprot

E3 ubiquitin-protein ligase Mdm2
type: DnaReference
xref: PTHR13844:SF15
organism: Danio rerio

STATE_TRANSITION
type: InteractionVocabulary

ncbitaxon 10116 32
type: UnificationXref
id: 10116
db: ncbitaxon

TRANSPORT
type: InteractionVocabulary

uniprot V5ILY7 172
type: UnificationXref
id: V5ILY7
db: uniprot

PTEN
type: ProteinReference
xref: P00905
standard name: Phosphatase and tensin homolog
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphatase and tensin homolog Synonym: PTEN,Phosphatidylinositol phosphate phosphatase,PtdIns phosphate phosphatase Accession: P00905
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.PTEN
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
member entity reference: MCG118205, isoform CRA_c
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
member entity reference: Putative tyrosine-protein phosphatase TPTE
member entity reference: IP16020p
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A

uniprot H9EPM1 156
type: UnificationXref
id: H9EPM1
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot F1NT98 206
xref: PTHR12305:SF81
organism: Gallus gallus

Insulin like growth factor 2 receptor
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot F6SWY2 30
organism: Monodelphis domestica

p110alpha
type: DnaRegionReference
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
xref: G04676
comment: ENTITY_REFERENCE_NOTES=Long Name: p110alpha Synonym: P110-alpha,PIK3CA Accession: G04676
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.GENE.GENE.p110_alpha_

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot A0A0G2K344 191
xref: PTHR10048:SF107
organism: Rattus norvegicus

uniprot G5E8H5 208
type: UnificationXref
id: G5E8H5
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot O54857 211
organism: Rattus norvegicus

Insulin receptor substrate 3, isoform CRA_a (Fragment)
type: ProteinReference
xref: PTHR10614:SF8
xref: uniprot O54718 110
organism: Mus musculus

uniprot P60484 214
type: UnificationXref
id: P60484
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
type: ProteinReference
xref: uniprot Q6P549 87
xref: PTHR46051:SF2
organism: Mus musculus

Tsc2 s13 sa7 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A0A2I3RUB7 52
type: UnificationXref
id: A0A2I3RUB7
db: uniprot

uniprot E2RB53 151
type: UnificationXref
id: E2RB53
db: uniprot

uniprot F1MYE0 105
type: UnificationXref
id: F1MYE0
db: uniprot

Insulin receptor-related protein
type: ProteinReference
xref: PTHR24416:SF338
xref: uniprot Q9WTL4 51
organism: Mus musculus

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot Q8T9S7 216
organism: Dictyostelium discoideum

uniprot Q9YH60 170
type: UnificationXref
id: Q9YH60
db: uniprot

uniprot P05019 70
type: UnificationXref
id: P05019
db: uniprot

ncbitaxon 8364 26
type: UnificationXref
id: 8364
db: ncbitaxon

PTHR24416:SF106
type: RelationshipXref
id: PTHR24416:SF106
db: PANTHER Family
relationship type: By Homology

IRS 1 4 s7 a7 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r26 271
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r26 270
type: Stoichiometry
physical entity: FKHR
stoichiometric coefficient: 1.0

uniprot Q8T9S7 216
type: UnificationXref
id: Q8T9S7
db: uniprot

ncbitaxon 9606 36
type: UnificationXref
id: 9606
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IRS_1_4-_ATP-RIGHT__IRS_1_4-_ADP-_r2
controller: Complex (Insulin IGF/INSR IGF-R IRR)

uniprot P07456 72
type: UnificationXref
id: P07456
db: uniprot

Glucose depreivation response
type: Pathway

Insulin receptor substrate 1
type: ProteinReference
xref: uniprot P35569 112
xref: PTHR10614:SF11
organism: Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F1Q3M8 194
xref: PTHR10048:SF107
organism: Canis lupus familiaris

Insulin receptor substrate 1
type: ProteinReference
xref: uniprot P35568 111
xref: PTHR10614:SF11
organism: Homo sapiens

uniprot E1BNT2 118
type: UnificationXref
id: E1BNT2
db: uniprot

ACTIVE 4
type: EntityFeature
comment: Active state

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 3

uniprot Q9Y4H2 115
type: UnificationXref
id: Q9Y4H2
db: uniprot

SHIP2
type: ProteinReference
xref: P00897
standard name: SH2 domain-containing inositol 5-phosphatase 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.SHIP2
comment: ENTITY_REFERENCE_NOTES=Long Name: SH2 domain-containing inositol 5-phosphatase 2 Synonym: INPP5D,Inositol polyphosphate-5-phosphatase,SHIP2 Accession: P00897
member entity reference: INPPL1 isoform 1
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
member entity reference: Inositol polyphosphate phosphatase like 1

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot H9FVU5 199
xref: PTHR10048:SF107
organism: Macaca mulatta

uniprot O15151 139
type: UnificationXref
id: O15151
db: uniprot

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 117

PARTICIPANT STOICHIOMETRY r30 252
type: Stoichiometry
physical entity: FKHR
stoichiometric coefficient: 1.0

Putative tyrosine-protein phosphatase TPTE
type: DnaReference
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r30 253
type: Stoichiometry
physical entity: FKHR
stoichiometric coefficient: 1.0

ATP
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot B8JIQ1 150
type: UnificationXref
id: B8JIQ1
db: uniprot

uniprot Q95V55 99
type: UnificationXref
id: Q95V55
db: uniprot

uniprot F6YCQ0 106
type: UnificationXref
id: F6YCQ0
db: uniprot

Tsc1
type: ProteinReference
xref: P04495
standard name: Tuberous sclerosis 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Hamartin Synonym: Tuberous sclerosis-1 Accession: P04495
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.Tsc1
member entity reference: Hamartin
member entity reference: TSC complex subunit 1
member entity reference: Uncharacterized protein

PARTICIPANT STOICHIOMETRY re37 244
type: Stoichiometry
physical entity: Complex (Tsc1/Tsc2)
stoichiometric coefficient: 1.0

eco ECO:0000316 117
type: UnificationXref
id: ECO:0000316
db: eco

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PiP2-RIGHT__PiP3-_r19
controller: Complex (PI3-K/P110alpha)

E3 ubiquitin-protein ligase Mdm2
type: DnaReference
xref: PTHR13844:SF15
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re37 245
type: Stoichiometry
physical entity: Complex (Tsc2/Tsc1)
stoichiometric coefficient: 1.0

uniprot P30410 76
type: UnificationXref
id: P30410
db: uniprot

Protein Mdm4
type: DnaReference
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r20 247
type: Stoichiometry
physical entity: PiP2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 246
type: Stoichiometry
physical entity: PiP3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 249
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

PTHR10614:SF13
type: RelationshipXref
id: PTHR10614:SF13
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re19 248
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

Insulin receptor substrate 1
type: ProteinReference
xref: PTHR10614:SF11
xref: uniprot P35570 113
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__p53-RIGHT__p53-_re22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 266
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 267
left: p53
interaction type: STATE_TRANSITION
right: p53

uniprot Q6P549 87
type: UnificationXref
id: Q6P549
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot Q9WVR3 88
organism: Rattus norvegicus

PTHR10614:SF11
type: RelationshipXref
id: PTHR10614:SF11
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9598 14
type: UnificationXref
id: 9598
db: ncbitaxon

Protein kinase gsk31
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot Q9URT9 166
organism: Schizosaccharomyces pombe

uniprot E2RDT3 133
type: UnificationXref
id: E2RDT3
db: uniprot

Glycogen synthase kinase-3
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot Q9U2Q9 165
organism: Caenorhabditis elegans

Insulin-like growth factor II
type: ProteinReference
xref: uniprot P07456 72
xref: PTHR46886:SF1
organism: Bos taurus

ncbitaxon 9615 20
type: UnificationXref
id: 9615
db: ncbitaxon

Insulin-like growth factor I
type: ProteinReference
xref: uniprot P07455 71
organism: Bos taurus

Forkhead box O3b
type: ProteinReference
xref: uniprot Q5TYS1 98
organism: Danio rerio

STATE_TRANSITION_LEFT__Mdm2-RIGHT__Mdm2-_re19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 248
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 249
left: Mdm2
interaction type: STATE_TRANSITION
right: Mdm2

Cation-independent mannose-6-phosphate receptor
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot Q07113 48
organism: Mus musculus

uniprot F1Q3M8 194
type: UnificationXref
id: F1Q3M8
db: uniprot