Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
3-phosphoinositide-dependent protein kinase 1
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A
3-phosphoinositide dependent protein kinase 1
Cation-independent mannose-6-phosphate receptor
ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.GENE.GENE.PTEN
ENTITY_REFERENCE_NOTES=Long Name: PTEN Synonym: Synonym not specified Accession: G04675
Insulin/IGF pathway-protein kinase B signaling cascade
MODEL_NOTES=Panther Pathway: P00033 The insulin receptor (IR), insulin-like growth factor receptor (IGFR), and insulin-receptor-related receptor (IRR) form a subgroup of receptor tyrosine kinases involved in regulating cellular growth and organismal metabolism. The activated IR regulates cellular uptake and metabolism of fuels, while the activated IGFR promotes cell growth, survival, and differentiation. Knockout mice studies have revealed the IGF-I receptor mediates IGF-I and IGF-II action on prenatal growth as well as IGF-I action on postnatal growth. The IR mediates prenatal growth in response to IGF-II and postnatal growth in response to insulin. All of these receptors share extensive structural homology and utilize the same downstream signalling cascades, one of which is illustrated here. Thus, how specificity is achieved in physiological outputs remains unclear, although it is thought to occur, in part, by differences in the locations and levels of receptor expression. Medline=11737239 Medline=11739335 Medline=11897402 Medline=12169433 Medline=12175645 Medline=12360255 PMID: 11737239 PMID: 11739335 PMID: 11897402 PMID: 12169433 PMID: 12175645 PMID: 12360255
ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.Insulin_br_IGF
ENTITY_REFERENCE_NOTES=Long Name: Insulin/Insulin like growth factor Synonym: IGF,IGF1,IGF2,Insulin like growth factor 1,Insulin like growth factor 2 Accession: P00896
ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.P110_alpha_
ENTITY_REFERENCE_NOTES=Long Name: P110alpha Synonym: P110-alpha,PIK3CA Accession: P04498
Putative tyrosine-protein phosphatase TPTE
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN1
Inositol polyphosphate phosphatase like 1
Insulin receptor/Insulin like growth factor receptor/insulin related receptor
ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.RECEPTOR.INSR_br_IGF_minus_R_br_IRR
ENTITY_REFERENCE_NOTES=Long Name: Insulin receptor/Insulin like growth factor receptor/insulin related receptor Synonym: IGF-R,IGF-R1,IGF-R2,INSR,IRR,Insulin R,Insulin like growth factor receptor 1,Insulin like growth factor receptor 2 Accession: P00895
Putative glycogen synthase kinase-3 homolog
ENTITY_REFERENCE_NOTES=Long Name: Mdm2 Synonym: Synonym not specified Accession: P04496 Pathway Link: P04398|P04663|p53 pathway feedback loops 2*P04392|P04536|P53 pathway feedback loops 1*P00059|P01483|p53 pathway
ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.Mdm2
Glycogen synthase kinase-3 beta isoform 1
ENTITY_REFERENCE_NOTES=Long Name: Tuberin Synonym: Synonym not specified Accession: P04494
ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.Tsc2
ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.IRS_space_1_minus_4
ENTITY_REFERENCE_NOTES=Long Name: Insulin receptor substrate family Synonym: IRS Accession: P00899
ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.GENE.GENE.Mdm2
ENTITY_REFERENCE_NOTES=Long Name: Mdm2 Synonym: Synonym not specified Accession: G04674
3-phosphoinositide-dependent protein kinase 1 and 2
ENTITY_REFERENCE_NOTES=Long Name: 3-phosphoinositide-dependent protein kinase Synonym: Synonym not specified Accession: P00903
ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.PDK1_slash_2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.GSK_minus_3
ENTITY_REFERENCE_NOTES=Long Name: Glycogen synthase kinase 3 Synonym: Synonym not specified Accession: P00902
ENTITY_REFERENCE_NOTES=Long Name: Forkhead transcription factor Synonym: FOXO1A,Forkhead box O1A,Forkhead in rhabdomyosarcoma Accession: P00898
ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.FKHR
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
ENTITY_REFERENCE_NOTES=Long Name: Phosphatase and tensin homolog Synonym: PTEN,Phosphatidylinositol phosphate phosphatase,PtdIns phosphate phosphatase Accession: P00905
ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.PTEN
ENTITY_REFERENCE_NOTES=Long Name: p110alpha Synonym: P110-alpha,PIK3CA Accession: G04676
ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.GENE.GENE.p110_alpha_
Insulin receptor substrate 3, isoform CRA_a (Fragment)
SH2 domain-containing inositol 5-phosphatase 2
ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.SHIP2
ENTITY_REFERENCE_NOTES=Long Name: SH2 domain-containing inositol 5-phosphatase 2 Synonym: INPP5D,Inositol polyphosphate-5-phosphatase,SHIP2 Accession: P00897
ENTITY_REFERENCE_NOTES=Long Name: Hamartin Synonym: Tuberous sclerosis-1 Accession: P04495
ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-protein kinase B signaling cascade.PROTEIN.GENERIC.Tsc1