uniprot F6YJ34 164
type: UnificationXref
id: F6YJ34
db: uniprot

uniprot A0A2I3RFV3 9
type: UnificationXref
id: A0A2I3RFV3
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 301
xref: uniprot P04049 314
xref: PTHR44329:SF22
organism: Homo sapiens

uniprot H9ENT4 172
type: UnificationXref
id: H9ENT4
db: uniprot

ncbitaxon 237561 241
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot Q0VD16 285
type: UnificationXref
id: Q0VD16
db: uniprot

uniprot Q9XTN2 132
type: UnificationXref
id: Q9XTN2
db: uniprot

uniprot Q15418 184
type: UnificationXref
id: Q15418
db: uniprot

uniprot Q9V3I5 195
type: UnificationXref
id: Q9V3I5
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 42

V-fos FBJ murine osteosarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot Q6P0S4 103
organism: Danio rerio

uniprot Q5U3B4 66
type: UnificationXref
id: Q5U3B4
db: uniprot

uniprot P15208 58
type: UnificationXref
id: P15208
db: uniprot

Insulin receptor substrate 1
type: ProteinReference
xref: PTHR10614:SF11
xref: uniprot F1MYE0 123
organism: Bos taurus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P28482 228
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F1PXS7 210
organism: Canis lupus familiaris

uniprot Q64716 68
type: UnificationXref
id: Q64716
db: uniprot

uniprot F7EPN2 116
type: UnificationXref
id: F7EPN2
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F1Q118 76
organism: Canis lupus familiaris

Proto-oncogene c-Fos
type: ProteinReference
xref: uniprot O77628 99
xref: PTHR23351:SF4
organism: Bos taurus

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P27361 225
xref: PTHR24055:SF393
organism: Homo sapiens

Insulin-like growth factor II
type: ProteinReference
xref: uniprot P33717 64
xref: PTHR46886:SF1
organism: Gallus gallus

uniprot F1PXS7 210
type: UnificationXref
id: F1PXS7
db: uniprot

uniprot F7DE94 125
type: UnificationXref
id: F7DE94
db: uniprot

Mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot F1LP57 266
organism: Rattus norvegicus

uniprot H2QJJ4 126
type: UnificationXref
id: H2QJJ4
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 255

uniprot F7BWW9 80
type: UnificationXref
id: F7BWW9
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot H9ENT4 172
xref: PTHR24351:SF48
organism: Macaca mulatta

SOS s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

uniprot E1B8P9 208
type: UnificationXref
id: E1B8P9
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot F6V2V1 163
organism: Ornithorhynchus anatinus

uniprot Q60751 67
type: UnificationXref
id: Q60751
db: uniprot

Insulin receptor-related protein
type: ProteinReference
xref: uniprot Q64716 68
xref: PTHR24416:SF338
organism: Rattus norvegicus

PTHR24351:SF213
type: RelationshipXref
id: PTHR24351:SF213
db: PANTHER Family
relationship type: By Homology

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot A4GTP4 256
organism: Rattus norvegicus

uniprot F7GLY8 274
type: UnificationXref
id: F7GLY8
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q01986 283
xref: PTHR48013:SF5
organism: Rattus norvegicus

uniprot Q5F3L1 187
type: UnificationXref
id: Q5F3L1
db: uniprot

uniprot G3V824 108
type: UnificationXref
id: G3V824
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F7FRY0 168
xref: PTHR24351:SF213
organism: Monodelphis domestica

ncbitaxon 39947 233
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot F1MV64 24
type: UnificationXref
id: F1MV64
db: uniprot

uniprot A0A1D5R9U8 300
type: UnificationXref
id: A0A1D5R9U8
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 10

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot F6UK84 160
organism: Xenopus tropicalis

PTHR10194:SF19
type: RelationshipXref
id: PTHR10194:SF19
db: PANTHER Family
relationship type: By Homology

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF41
xref: uniprot F1MQE1 155
organism: Bos taurus

Map2k3 protein
type: ProteinReference
xref: uniprot B1H230 264
xref: PTHR48013:SF21
organism: Rattus norvegicus

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ribosomal protein S6 kinase alpha-5
type: ProteinReference
xref: PTHR24351:SF115
xref: uniprot Q5F3L1 187
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
evidence: Evidence 302
evidence: Evidence 301
evidence: Evidence 303
evidence: Evidence 304
xref: uniprot A0A1D5R9U8 300
xref: PTHR44329:SF22
organism: Macaca mulatta

P90 RSK s27 a40 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q07889 86
type: UnificationXref
id: Q07889
db: uniprot

Protein kinase superfamily protein
type: ProteinReference
xref: uniprot F4JQX7 309
organism: Arabidopsis thaliana

uniprot D3ZSB7 147
type: UnificationXref
id: D3ZSB7
db: uniprot

ETS domain-containing protein Elk-1
type: ProteinReference
xref: uniprot P41969 258
xref: PTHR11849:SF178
organism: Mus musculus

Ribosomal protein S6 kinase beta-2
type: ProteinReference
xref: uniprot Q9Z1M4 198
xref: PTHR24351:SF171
organism: Mus musculus

Dual-specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot F1NYZ2 267
xref: PTHR48013:SF8
organism: Gallus gallus

Cation-independent mannose-6-phosphate receptor
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot P08169 110
organism: Bos taurus

Insulin receptor substrate 1
type: ProteinReference
xref: PTHR10614:SF13
xref: uniprot Q9XTN2 132
organism: Drosophila melanogaster

uniprot P09535 55
type: UnificationXref
id: P09535
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F7H7W3 169
xref: PTHR24351:SF43
organism: Macaca mulatta

Mitogen-activated protein kinase 4
type: ProteinReference
xref: uniprot Q5Z859 242
organism: Oryza sativa

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 303
xref: uniprot P11345 316
xref: PTHR44329:SF22
organism: Rattus norvegicus

uniprot E9PYG6 113
type: UnificationXref
id: E9PYG6
db: uniprot

uniprot P36507 281
type: UnificationXref
id: P36507
db: uniprot

uniprot Q9Z1M4 198
type: UnificationXref
id: Q9Z1M4
db: uniprot

uniprot F6S876 157
type: UnificationXref
id: F6S876
db: uniprot

Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
type: Pathway
pathway component: STATE_TRANSITION_LEFT__ELK-RIGHT__ELK-_r13
pathway component: STATE_TRANSITION_LEFT__ATP-_MEK-RIGHT__MEK-_ADP-_r9
pathway component: STATE_TRANSITION_LEFT__P90_RSK-RIGHT__P90_RSK-_r14
pathway component: HETERODIMER_ASSOCIATION_LEFT__Grb2-_SOS-RIGHT__Complex__SOS_Grb2_-_r5
pathway component: STATE_TRANSITION_LEFT__c_fos-RIGHT__c_fos-_r15
pathway component: PHYSICAL_STIMULATION
pathway component: STATE_TRANSITION_LEFT__ATP-_IRS_1_4-RIGHT__IRS_1_4-_ADP-_r2
pathway component: STATE_TRANSITION_LEFT__ATP-_ERK-RIGHT__ERK-_ADP-_r11
pathway component: HETERODIMER_ASSOCIATION_LEFT__Insulin_IGF-_INSR_IGF_R_IRR-RIGHT__Complex__Insulin_IGF_INSR_IGF_R_IRR_-_r1
pathway component: STATE_TRANSITION_LEFT__Grb2-RIGHT__Grb2-_r4
pathway component: STATE_TRANSITION_LEFT__ATP-_Raf-RIGHT__Raf-_ADP-_r7
pathway component: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r6
xref: PANTHER Pathway P00032 1
comment: MODEL_NOTES=Panther Pathway: P00032 The insulin receptor (IR), insulin-like growth factor receptor (IGFR), and insulin-receptor-related receptor (IRR) form a subgroup of receptor tyrosine kinases that activate the mitogenic MAP kinase signalling cascade. The activated IR regulates cellular uptake and metabolism of fuels, while the activated IGFR promotes cell growth. Medline=11737239 Medline=11739335 Medline=11897402 Medline=12169433 Medline=12175645 Medline=12360255 PMID: 11737239 PMID: 11739335 PMID: 11897402 PMID: 12169433 PMID: 12175645 PMID: 12360255

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot A0A3Q1MNG1 262
organism: Bos taurus

uniprot Q63932 289
type: UnificationXref
id: Q63932
db: uniprot

uniprot O73727 34
type: UnificationXref
id: O73727
db: uniprot

uniprot F7EH19 214
type: UnificationXref
id: F7EH19
db: uniprot

MEK
type: Protein
entity reference: MEK
feature: ACTIVE 104
feature: MEK s24 a27 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q63844 243
xref: PTHR24055:SF393
organism: Mus musculus

PTHR23351:SF4
type: RelationshipXref
id: PTHR23351:SF4
db: PANTHER Family
relationship type: By Homology

uniprot H2RA86 218
type: UnificationXref
id: H2RA86
db: uniprot

Raf
type: Protein
entity reference: Raf
feature: Raf s23 a21 rs1
feature: ACTIVE 104
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q8JIE4 69
type: UnificationXref
id: Q8JIE4
db: uniprot

uniprot E2RP04 153
type: UnificationXref
id: E2RP04
db: uniprot

uniprot P35569 130
type: UnificationXref
id: P35569
db: uniprot

Mitogen-activated protein kinase 11
type: ProteinReference
xref: uniprot Q9LMM5 251
organism: Arabidopsis thaliana

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot Q07890 87
xref: PTHR23113:SF150
organism: Homo sapiens

uniprot P19419 257
type: UnificationXref
id: P19419
db: uniprot

uniprot A0A1D5Q5Z6 202
type: UnificationXref
id: A0A1D5Q5Z6
db: uniprot

Mitogen-activated protein kinase FUS3
type: ProteinReference
xref: uniprot P16892 223
xref: PTHR24055:SF158
organism: Saccharomyces cerevisiae

Uncharacterized protein
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot A0A1D5P7X1 105
organism: Gallus gallus

ncbitaxon 367110 255
type: UnificationXref
id: 367110
db: ncbitaxon

Os01g0641000 protein
type: ProteinReference
xref: uniprot Q8LQ53 319
organism: Oryza sativa

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot E1BLQ5 149
xref: PTHR24351:SF171
organism: Bos taurus

uniprot Q9WUT3 197
type: UnificationXref
id: Q9WUT3
db: uniprot

PARTICIPANT STOICHIOMETRY r13 353
type: Stoichiometry
physical entity: ELK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 354
type: Stoichiometry
physical entity: ELK
stoichiometric coefficient: 1.0

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F7BWW9 80
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r14 352
type: Stoichiometry
physical entity: P90 RSK
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 4
type: ProteinReference
xref: uniprot Q39024 237
organism: Arabidopsis thaliana

uniprot O75676 176
type: UnificationXref
id: O75676
db: uniprot

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot Q39027 239
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot Q39026 238
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot Q39021 234
organism: Arabidopsis thaliana

uniprot F6URW3 78
type: UnificationXref
id: F6URW3
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q39023 236
organism: Arabidopsis thaliana

uniprot B1H230 264
type: UnificationXref
id: B1H230
db: uniprot

PARTICIPANT STOICHIOMETRY r14 351
type: Stoichiometry
physical entity: P90 RSK
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 2
type: ProteinReference
xref: uniprot Q39022 235
organism: Arabidopsis thaliana

PTHR46037:SF4
type: RelationshipXref
id: PTHR46037:SF4
db: PANTHER Family
relationship type: By Homology

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 8

00696
type: UnificationXref
id: MOD:00696
db: mod

uniprot H2QA49 33
type: UnificationXref
id: H2QA49
db: uniprot

Protein son of sevenless
type: ProteinReference
xref: uniprot P26675 84
xref: PTHR23113:SF341
organism: Drosophila melanogaster

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2RA86 218
xref: PTHR24055:SF393
organism: Pan troglodytes

uniprot F7FHD1 216
type: UnificationXref
id: F7FHD1
db: uniprot

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot Q60631 297
xref: PTHR46037:SF4
organism: Mus musculus

uniprot Q6P0S4 103
type: UnificationXref
id: Q6P0S4
db: uniprot

Mitogen-activated protein kinase kinase 4A
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot B1NA68 265
organism: Danio rerio

PTHR46037:SF1
type: RelationshipXref
id: PTHR46037:SF1
db: PANTHER Family
relationship type: By Homology

At5g58950
type: ProteinReference
xref: uniprot Q9FIL6 325
organism: Arabidopsis thaliana

uniprot E2RDB5 122
type: UnificationXref
id: E2RDB5
db: uniprot

uniprot F4HVH9 307
type: UnificationXref
id: F4HVH9
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 302
xref: PTHR44329:SF22
xref: uniprot P05625 315
organism: Gallus gallus

Ribosomal protein S6 kinase alpha-2
type: ProteinReference
xref: uniprot Q15349 183
xref: PTHR24351:SF213
organism: Homo sapiens

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF213
xref: uniprot A0A3Q2UBK0 143
organism: Gallus gallus

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF110
xref: uniprot A8XFY3 144
organism: Caenorhabditis briggsae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r6
controller: Complex (SOS/Grb2)

ncbitaxon 9606 36
type: UnificationXref
id: 9606
db: ncbitaxon

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot E2RPM8 22
xref: PTHR24416:SF535
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot F7DNM3 115
organism: Macaca mulatta

ncbitaxon 7668 260
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot F6SDH6 158
type: UnificationXref
id: F6SDH6
db: uniprot

uniprot F6V2V1 163
type: UnificationXref
id: F6V2V1
db: uniprot

ncbitaxon 44689 89
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot F1N7C3 74
type: UnificationXref
id: F1N7C3
db: uniprot

uniprot F7EI48 215
type: UnificationXref
id: F7EI48
db: uniprot

ncbitaxon 9544 8
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot K7BI90 173
type: UnificationXref
id: K7BI90
db: uniprot

uniprot P27638 226
type: UnificationXref
id: P27638
db: uniprot

uniprot Q8IS21 92
type: UnificationXref
id: Q8IS21
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XT65 272
xref: PTHR48013:SF5
organism: Monodelphis domestica

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot E2R7K9 151
xref: PTHR24351:SF171
organism: Canis lupus familiaris

Probable serine/threonine-protein kinase DDB_G0271682
type: ProteinReference
xref: uniprot Q86HG9 318
organism: Dictyostelium discoideum

ELK
type: ProteinReference
xref: P00890
standard name: ELK1, member of ETS oncogen family
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: ELK1, member of ETS oncogen family Synonym: ELK1,Oncogen ELK1 Accession: P00890
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade.PROTEIN.GENERIC.ELK
member entity reference: ETS domain-containing protein Elk-1
member entity reference: Transcription factor Elk; Uncharacterized protein

INSR IGF R IRR s10 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: INSR IGF-R IRR
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Raf-RIGHT__Raf-_ADP-_r7
controller: Ras

uniprot P67970 65
type: UnificationXref
id: P67970
db: uniprot

uniprot F6UK84 160
type: UnificationXref
id: F6UK84
db: uniprot

eco ECO:0000304 59
type: UnificationXref
id: ECO:0000304
db: eco

uniprot P01101 101
type: UnificationXref
id: P01101
db: uniprot

uniprot F7EI91 98
type: UnificationXref
id: F7EI91
db: uniprot

uniprot F6QUB0 27
type: UnificationXref
id: F6QUB0
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot D4A3T0 72
organism: Rattus norvegicus

STATE_TRANSITION
type: RelationshipTypeVocabulary

c fos s20 a42 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 250

Growth factor receptor-bound protein 2a
type: ProteinReference
xref: PTHR46037:SF4
xref: uniprot Q5RKN6 296
organism: Danio rerio

Serine/threonine-protein kinase STY13
type: ProteinReference
xref: uniprot Q9ZQ31 328
organism: Arabidopsis thaliana

uniprot F1PXD3 269
type: UnificationXref
id: F1PXD3
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: uniprot P46734 282
xref: PTHR48013:SF21
organism: Homo sapiens

uniprot F6ZM17 165
type: UnificationXref
id: F6ZM17
db: uniprot

Insulin receptor
type: ProteinReference
xref: uniprot P15127 57
xref: PTHR24416:SF535
organism: Rattus norvegicus

ncbitaxon 8364 14
type: UnificationXref
id: 8364
db: ncbitaxon

MEK s24 a27 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Serine/threonine-protein kinase STY46
type: ProteinReference
xref: uniprot F4JTP5 310
organism: Arabidopsis thaliana

uniprot O09110 277
type: UnificationXref
id: O09110
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__c_fos-RIGHT__c_fos-_r15
controller: P90 RSK

uniprot O61444 278
type: UnificationXref
id: O61444
db: uniprot

Mitogen-activated protein kinase mpk-1
type: ProteinReference
xref: uniprot P39745 229
xref: PTHR24055:SF158
organism: Caenorhabditis elegans

uniprot Q8SSQ0 93
type: UnificationXref
id: Q8SSQ0
db: uniprot

uniprot F6YCI3 79
type: UnificationXref
id: F6YCI3
db: uniprot

PTHR44329:SF22
type: RelationshipXref
id: PTHR44329:SF22
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot H2QA49 33
xref: PTHR24416:SF106
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r9 359
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot F1MC23 23
xref: PTHR24416:SF338
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r9 362
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 145

PARTICIPANT STOICHIOMETRY r9 361
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

Ras guanine nucleotide exchange factor R
type: ProteinReference
xref: uniprot Q8SSQ0 93
organism: Dictyostelium discoideum

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 186

Insulin like growth factor 1
type: ProteinReference
xref: uniprot F6PZT8 25
organism: Ornithorhynchus anatinus

uniprot P29355 294
type: UnificationXref
id: P29355
db: uniprot

uniprot Q5ZIF0 288
type: UnificationXref
id: Q5ZIF0
db: uniprot

uniprot Q9FIL6 325
type: UnificationXref
id: Q9FIL6
db: uniprot

PARTICIPANT STOICHIOMETRY r9 360
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

uniprot Q99N57 323
type: UnificationXref
id: Q99N57
db: uniprot

uniprot F7BRK5 311
type: UnificationXref
id: F7BRK5
db: uniprot

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 302
evidence: Evidence 301
evidence: Evidence 303
evidence: Evidence 304
xref: uniprot E2REI6 306
xref: PTHR44329:SF22
organism: Canis lupus familiaris

uniprot A0A1D5QKD3 261
type: UnificationXref
id: A0A1D5QKD3
db: uniprot

uniprot Q39026 238
type: UnificationXref
id: Q39026
db: uniprot

Son of sevenless homolog 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot Q07889 86
organism: Homo sapiens

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF213
xref: uniprot F1M7N7 154
organism: Rattus norvegicus

uniprot F6RDI1 106
type: UnificationXref
id: F6RDI1
db: uniprot

uniprot Q6P023 244
type: UnificationXref
id: Q6P023
db: uniprot

uniprot P01326 43
type: UnificationXref
id: P01326
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot K7DH81 174
xref: PTHR24351:SF115
organism: Pan troglodytes

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7EI48 215
xref: PTHR24055:SF393
organism: Monodelphis domestica

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot E2R2N2 209
organism: Canis lupus familiaris

MAP kinase kinase 4, isoform A
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot O61444 278
organism: Drosophila melanogaster

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: uniprot O09110 277
xref: PTHR48013:SF21
organism: Mus musculus

ncbitaxon 7227 54
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot Q84UI5 248
type: UnificationXref
id: Q84UI5
db: uniprot

uniprot P05019 47
type: UnificationXref
id: P05019
db: uniprot

uniprot K7BYT0 276
type: UnificationXref
id: K7BYT0
db: uniprot

uniprot E2REI6 306
type: UnificationXref
id: E2REI6
db: uniprot

Insulin receptor substrate 3
type: ProteinReference
xref: PTHR10614:SF8
xref: uniprot B1WBQ1 121
organism: Rattus norvegicus

uniprot F1P859 75
type: UnificationXref
id: F1P859
db: uniprot

PARTICIPANT STOICHIOMETRY r1 346
type: Stoichiometry
physical entity: Insulin IGF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 348
type: Stoichiometry
physical entity: Complex (Insulin IGF/INSR IGF-R IRR)
stoichiometric coefficient: 1.0

uniprot F6YCQ0 124
type: UnificationXref
id: F6YCQ0
db: uniprot

PARTICIPANT STOICHIOMETRY r1 347
type: Stoichiometry
physical entity: INSR IGF-R IRR
stoichiometric coefficient: 1.0

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 205

STATE_TRANSITION_LEFT__Grb2-RIGHT__Grb2-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 341
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 340
left: Grb2
interaction type: STATE_TRANSITION
right: Grb2

uniprot A0A2I3THL4 305
type: UnificationXref
id: A0A2I3THL4
db: uniprot

uniprot Q8RWL6 320
type: UnificationXref
id: Q8RWL6
db: uniprot

uniprot F1P4J0 156
type: UnificationXref
id: F1P4J0
db: uniprot

uniprot Q08012 295
type: UnificationXref
id: Q08012
db: uniprot

uniprot E2QYK5 96
type: UnificationXref
id: E2QYK5
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot C8V7D1 206
organism: Emericella nidulans

Raf
type: ProteinReference
xref: P00893
standard name: Raf Oncogene
comment: ENTITY_REFERENCE_NOTES=Long Name: Raf Synonym: Raf oncogene Accession: P00893
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade.PROTEIN.GENERIC.Raf
member entity reference: Serine/threonine-protein kinase STY17
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase STY46
member entity reference: PAS domain-containing protein tyrosine kinase family protein
member entity reference: Os01g0641000 protein
member entity reference: Probable serine/threonine-protein kinase SIS8
member entity reference: RAF proto-oncogene serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase CTR1
member entity reference: AT4G31170 protein
member entity reference: AT5g11850/F14F18_20
member entity reference: At5g58950
member entity reference: Raf-1 proto-oncogene, serine/threonine kinase
member entity reference: Serine/threonine-protein kinase STY13
member entity reference: Serine/threonine-protein kinase STY8
member entity reference: Serine/threonine-protein kinase EDR1
member entity reference: Protein kinase superfamily protein
member entity reference: AT3g58640/F14P22_230
member entity reference: Probable serine/threonine-protein kinase DDB_G0271682

STATE_TRANSITION_LEFT__ATP-_ERK-RIGHT__ERK-_ADP-_r11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 357
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 358
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 355
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 356
left: ERK
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: ERK

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot A0A1D5R6B6 7
xref: PTHR24416:SF106
organism: Macaca mulatta

PTHR23113:SF168
type: RelationshipXref
id: PTHR23113:SF168
db: PANTHER Family
relationship type: By Homology

INSR IGF-R IRR
type: Protein
entity reference: INSR IGF-R IRR
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Insulin-like growth factor 2
type: ProteinReference
xref: PTHR46886:SF1
xref: uniprot F6QUB0 27
organism: Xenopus tropicalis

ncbitaxon 9615 21
type: UnificationXref
id: 9615
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Grb2-RIGHT__Grb2-_r4
controller: IRS 1-4

IRS 1-4
type: Protein
entity reference: IRS 1-4
feature: ACTIVE 104
feature: IRS 1 4 s22 a8 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F5HEA9 211
type: UnificationXref
id: F5HEA9
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 19

uniprot Q90VV9 70
type: UnificationXref
id: Q90VV9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YCI3 79
xref: PTHR23113:SF150
organism: Monodelphis domestica

uniprot P18652 177
type: UnificationXref
id: P18652
db: uniprot

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot P12841 102
organism: Rattus norvegicus

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 5

uniprot P21708 224
type: UnificationXref
id: P21708
db: uniprot

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: uniprot F1PXD3 269
xref: PTHR48013:SF21
organism: Canis lupus familiaris

uniprot P01323 40
type: UnificationXref
id: P01323
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Insulin_IGF-_INSR_IGF_R_IRR-RIGHT__Complex__Insulin_IGF_INSR_IGF_R_IRR_-_r1
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 346
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 347
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 348
left: Insulin IGF
left: INSR IGF-R IRR
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Insulin IGF/INSR IGF-R IRR)

uniprot F6PZT8 25
type: UnificationXref
id: F6PZT8
db: uniprot

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r5 339
type: Stoichiometry
physical entity: Complex (SOS/Grb2)
stoichiometric coefficient: 1.0

uniprot Q63844 243
type: UnificationXref
id: Q63844
db: uniprot

PARTICIPANT STOICHIOMETRY r5 338
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

uniprot Q7PRZ7 291
type: UnificationXref
id: Q7PRZ7
db: uniprot

PARTICIPANT STOICHIOMETRY r5 337
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

INSR IGF-R IRR
type: Protein
entity reference: INSR IGF-R IRR
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa2 332
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9Y4H2 133
type: UnificationXref
id: Q9Y4H2
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 30

uniprot Q07113 112
type: UnificationXref
id: Q07113
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot Q9M1Z5 253
organism: Arabidopsis thaliana

Uncharacterized protein
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot F6RDI1 106
organism: Macaca mulatta

uniprot H2QDK7 171
type: UnificationXref
id: H2QDK7
db: uniprot

Raf s15 a20 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Ribosomal protein S6 kinase alpha-6
type: ProteinReference
xref: PTHR24351:SF98
xref: uniprot Q9UK32 194
organism: Homo sapiens

Transcription factor Elk; Uncharacterized protein
type: ProteinReference
xref: uniprot Q95UJ1 259
xref: PTHR11849:SF133
organism: Strongylocentrotus purpuratus

Insulin-like growth factor 2 receptor
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot K7B5K7 109
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_IRS_1_4-RIGHT__IRS_1_4-_ADP-_r2
controller: Complex (Insulin IGF/INSR IGF-R IRR)

ncbitaxon 227321 207
type: UnificationXref
id: 227321
db: ncbitaxon

Ribosomal protein S6 kinase alpha-2
type: ProteinReference
xref: PTHR24351:SF213
xref: uniprot Q9WUT3 197
organism: Mus musculus

AT5g11850/F14F18_20
type: ProteinReference
xref: uniprot Q8S9K4 321
organism: Arabidopsis thaliana

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot F6UNV6 161
organism: Macaca mulatta

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot F1MV64 24
xref: PTHR24416:SF535
organism: Bos taurus

uniprot A4GTP4 256
type: UnificationXref
id: A4GTP4
db: uniprot

Ras GTPase-activating protein 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot F1N7N8 114
organism: Bos taurus

PAS domain-containing protein tyrosine kinase family protein
type: ProteinReference
xref: uniprot O82754 313
organism: Arabidopsis thaliana

Raf
type: Protein
entity reference: Raf
feature: Raf s15 a20 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot O77628 99
type: UnificationXref
id: O77628
db: uniprot

Insulin-like growth factor 1
type: ProteinReference
xref: uniprot F6V1C3 31
organism: Xenopus tropicalis

STATE_TRANSITION_LEFT__P90_RSK-RIGHT__P90_RSK-_r14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 351
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 352
left: P90 RSK
interaction type: STATE_TRANSITION
right: P90 RSK

Mitogen-activated protein kinase spk1
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot P27638 226
organism: Schizosaccharomyces pombe

ncbitaxon 10116 39
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot E1BLQ5 149
type: UnificationXref
id: E1BLQ5
db: uniprot

uniprot A0A2I3RUB7 11
type: UnificationXref
id: A0A2I3RUB7
db: uniprot

Putative ribosomal protein S6 kinase alpha-1
type: ProteinReference
xref: PTHR24351:SF110
xref: uniprot Q21734 185
organism: Caenorhabditis elegans

uniprot O23236 219
type: UnificationXref
id: O23236
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A3Q1MLN6 142
xref: PTHR24351:SF43
organism: Bos taurus

Ribosomal protein S6 kinase alpha-5
type: ProteinReference
xref: uniprot O75582 175
xref: PTHR24351:SF115
organism: Homo sapiens

Ribosomal protein S6 kinase alpha-3
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot P18654 179
organism: Mus musculus

Ribosomal protein S6 kinase alpha-1
type: ProteinReference
xref: uniprot P18653 178
xref: PTHR24351:SF43
organism: Mus musculus

Ribosomal protein S6 kinase 2 alpha
type: ProteinReference
xref: PTHR24351:SF43
xref: uniprot P18652 177
organism: Gallus gallus

P90 RSK s19 a39 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 302
evidence: Evidence 301
evidence: Evidence 303
evidence: Evidence 304
xref: PTHR44329:SF22
xref: uniprot A0A2I3THL4 305
organism: Pan troglodytes

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 220

uniprot F6WX28 97
type: UnificationXref
id: F6WX28
db: uniprot

uniprot F6QWD3 28
type: UnificationXref
id: F6QWD3
db: uniprot

uniprot A0A0R4IGP2 3
type: UnificationXref
id: A0A0R4IGP2
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P21708 224
organism: Rattus norvegicus

uniprot D4AE24 148
type: UnificationXref
id: D4AE24
db: uniprot

ncbitaxon 665079 205
type: UnificationXref
id: 665079
db: ncbitaxon

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F1P4J0 156
xref: PTHR24351:SF48
organism: Gallus gallus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot E2RP04 153
organism: Canis lupus familiaris

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot F6QWD3 28
xref: PTHR24416:SF106
organism: Xenopus tropicalis

Ribosomal protein S6 kinase beta-2
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot Q9UBS0 193
organism: Homo sapiens

Danio rerio
type: BioSource
xref: ncbitaxon 7955 4

uniprot F1N7N8 114
type: UnificationXref
id: F1N7N8
db: uniprot

PARTICIPANT STOICHIOMETRY r4 341
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 340
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

Ras
type: ProteinReference
xref: P00886
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade.PROTEIN.GENERIC.Ras
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Ras Synonym: Synonym not specified Accession: P00886
member entity reference: RAS p21 protein activator 1
member entity reference: RAS p21 protein activator (GTPase activating protein) 1
member entity reference: Ras GTPase-activating protein 1
member entity reference: Uncharacterized protein

uniprot P01325 41
type: UnificationXref
id: P01325
db: uniprot

ncbitaxon 7955 4
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot P01321 37
type: UnificationXref
id: P01321
db: uniprot

Insulin
type: ProteinReference
xref: uniprot A5PJB2 15
organism: Bos taurus

Insulin-like growth factor I
type: ProteinReference
xref: uniprot P18254 60
organism: Gallus gallus

uniprot Q9M085 327
type: UnificationXref
id: Q9M085
db: uniprot

Ras guanine nucleotide exchange factor B
type: ProteinReference
xref: uniprot Q8IS21 92
organism: Dictyostelium discoideum

uniprot A0A1D5P7X1 105
type: UnificationXref
id: A0A1D5P7X1
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7CQS0 167
xref: PTHR24351:SF171
organism: Macaca mulatta

PTHR24416:SF338
type: RelationshipXref
id: PTHR24416:SF338
db: PANTHER Family
relationship type: By Homology

uniprot A0A3Q1MNG1 262
type: UnificationXref
id: A0A3Q1MNG1
db: uniprot

Ras guanine nucleotide exchange factor A
type: ProteinReference
xref: uniprot Q54PQ4 88
organism: Dictyostelium discoideum

Insulin receptor
type: ProteinReference
xref: uniprot P06213 48
xref: PTHR24416:SF535
organism: Homo sapiens

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 201

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F1N7C3 74
organism: Bos taurus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63085 230
organism: Mus musculus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63086 231
organism: Rattus norvegicus

Grb2 s4 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot A0A0D1C4Y4 200
organism: Ustilago maydis

uniprot P11345 316
type: UnificationXref
id: P11345
db: uniprot

uniprot Q7QDB4 189
type: UnificationXref
id: Q7QDB4
db: uniprot

Protein enhancer of sevenless 2B
type: ProteinReference
xref: uniprot Q08012 295
xref: PTHR46037:SF1
organism: Drosophila melanogaster

uniprot P35570 131
type: UnificationXref
id: P35570
db: uniprot

uniprot F1M7N7 154
type: UnificationXref
id: F1M7N7
db: uniprot

PTHR10614:SF2
type: RelationshipXref
id: PTHR10614:SF2
db: PANTHER Family
relationship type: By Homology

ERK
type: Protein
entity reference: ERK
feature: ERK s17 a31 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 5
type: ProteinReference
xref: uniprot Q10N20 232
organism: Oryza sativa

PTHR10614:SF7
type: RelationshipXref
id: PTHR10614:SF7
db: PANTHER Family
relationship type: By Homology

uniprot B1WBQ1 121
type: UnificationXref
id: B1WBQ1
db: uniprot

PTHR10614:SF8
type: RelationshipXref
id: PTHR10614:SF8
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot O23236 219
organism: Arabidopsis thaliana

Serine/threonine-protein kinase STY17
type: ProteinReference
xref: uniprot Q8RWL6 320
organism: Arabidopsis thaliana

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: uniprot F6PXH5 270
xref: PTHR48013:SF21
organism: Ornithorhynchus anatinus

uniprot Q9UBS0 193
type: UnificationXref
id: Q9UBS0
db: uniprot

ELK s18 a36 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

INSR IGF-R IRR
type: ProteinReference
xref: P00885
standard name: Insulin receptor/Insulin like growth factor receptor/insulin related receptor
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade.PROTEIN.RECEPTOR.INSR_br_IGF_minus_R_br_IRR
comment: ENTITY_REFERENCE_NOTES=Long Name: Insulin receptor/Insulin like growth factor receptor/insulin related receptor Synonym: IGF-R,IGF-R1,IGF-R2,INSR,IRR,Insulin R,Insulin like growth factor receptor 1,Insulin like growth factor receptor 2 Accession: P00885
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Cation-independent mannose-6-phosphate receptor
member entity reference: Insulin like growth factor 2 receptor
member entity reference: Insulin-like growth factor 1 receptor
member entity reference: Tyrosine-protein kinase receptor
member entity reference: Uncharacterized protein
member entity reference: Insulin receptor-related protein
member entity reference: Insulin receptor
member entity reference: Insulin-like growth factor 2 receptor

uniprot A5A6H2 95
type: UnificationXref
id: A5A6H2
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 302
evidence: Evidence 301
evidence: Evidence 303
evidence: Evidence 304
xref: uniprot F7BRK5 311
xref: PTHR44329:SF22
organism: Monodelphis domestica

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q02750 284
xref: PTHR48013:SF5
organism: Homo sapiens

Son of sevenless homolog 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot Q62245 91
organism: Mus musculus

Mitogen-activated protein kinase (Fragment)
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot Q7PVR1 246
organism: Anopheles gambiae

Ras
type: Protein
entity reference: Ras
feature: ACTIVE 104
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__ATP-_MEK-RIGHT__MEK-_ADP-_r9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 362
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 361
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 360
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 359
left: MEK
left: ATP
interaction type: STATE_TRANSITION
right: MEK
right: ADP

uniprot Q9Z2B9 199
type: UnificationXref
id: Q9Z2B9
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot F6YJ34 164
organism: Monodelphis domestica

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 39

uniprot K7CZM1 83
type: UnificationXref
id: K7CZM1
db: uniprot

Insulin-like growth factor 1
type: ProteinReference
xref: uniprot Q90VV9 70
organism: Danio rerio

Growth factor receptor-bound protein 2
type: ProteinReference
evidence: Evidence 299
xref: uniprot Q6PC73 298
xref: PTHR46037:SF4
organism: Danio rerio

uniprot Q1HG70 286
type: UnificationXref
id: Q1HG70
db: uniprot

uniprot F4JC18 308
type: UnificationXref
id: F4JC18
db: uniprot

IRS 1-4
type: Protein
entity reference: IRS 1-4
feature: IRS 1 4 s7 a7 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Ras
type: Protein
entity reference: Ras
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A5PJB2 15
type: UnificationXref
id: A5PJB2
db: uniprot

uniprot A0A3Q1LNQ6 140
type: UnificationXref
id: A0A3Q1LNQ6
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

uniprot F1MYE0 123
type: UnificationXref
id: F1MYE0
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot D3Z8E0 146
organism: Rattus norvegicus

Protein CBR-SEM-5
type: ProteinReference
xref: uniprot A8XPY6 293
xref: PTHR46037:SF1
organism: Caenorhabditis briggsae

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

uniprot F1Q118 76
type: UnificationXref
id: F1Q118
db: uniprot

uniprot P01344 44
type: UnificationXref
id: P01344
db: uniprot

uniprot Q8S9K4 321
type: UnificationXref
id: Q8S9K4
db: uniprot

ncbitaxon 7165 190
type: UnificationXref
id: 7165
db: ncbitaxon

Serine/threonine-protein kinase STY8
type: ProteinReference
xref: uniprot O22558 312
organism: Arabidopsis thaliana

By Homology
type: RelationshipTypeVocabulary

Insulin receptor substrate 2
type: ProteinReference
xref: uniprot F7DE94 125
xref: PTHR10614:SF7
organism: Macaca mulatta

uniprot Q01986 283
type: UnificationXref
id: Q01986
db: uniprot

uniprot B1NA68 265
type: UnificationXref
id: B1NA68
db: uniprot

Evidence 299
type: Evidence
evidence code: ISS
comment: Website http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF43
xref: uniprot F6S876 157
organism: Xenopus tropicalis

uniprot P63086 231
type: UnificationXref
id: P63086
db: uniprot

uniprot Q6Z437 245
type: UnificationXref
id: Q6Z437
db: uniprot

Insulin like growth factor 2 receptor
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot F6SWY2 107
organism: Monodelphis domestica

uniprot H2QR74 117
type: UnificationXref
id: H2QR74
db: uniprot

uniprot F1NYZ2 267
type: UnificationXref
id: F1NYZ2
db: uniprot

uniprot P16892 223
type: UnificationXref
id: P16892
db: uniprot

SOS
type: Protein
entity reference: SOS
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Insulin receptor substrate 3, isoform CRA_a (Fragment)
type: ProteinReference
xref: PTHR10614:SF8
xref: uniprot O54718 128
organism: Mus musculus

ncbitaxon 10090 42
type: UnificationXref
id: 10090
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_ERK-RIGHT__ERK-_ADP-_r11
controller: MEK

PTHR24416:SF106
type: RelationshipXref
id: PTHR24416:SF106
db: PANTHER Family
relationship type: By Homology

uniprot P20936 118
type: UnificationXref
id: P20936
db: uniprot

ERK s25 a32 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5ZIF0 288
xref: PTHR48013:SF5
organism: Gallus gallus

uniprot O14654 127
type: UnificationXref
id: O14654
db: uniprot

ncbitaxon 284812 227
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot A0A3Q2UBK0 143
type: UnificationXref
id: A0A3Q2UBK0
db: uniprot

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR23113:SF150
type: RelationshipXref
id: PTHR23113:SF150
db: PANTHER Family
relationship type: By Homology

uniprot Q07890 87
type: UnificationXref
id: Q07890
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot P36507 281
xref: PTHR48013:SF8
organism: Homo sapiens

uniprot E2R2N2 209
type: UnificationXref
id: E2R2N2
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36506 280
organism: Rattus norvegicus

ncbitaxon 9031 61
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot P08069 52
type: UnificationXref
id: P08069
db: uniprot

ncbitaxon 9598 10
type: UnificationXref
id: 9598
db: ncbitaxon

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: ELK

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

SOS
type: ProteinReference
xref: P00883
standard name: Son of sevenless
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Son of sevenless Synonym: SOS,SOS1 guanine nucleotide exchange factor Accession: P00883
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade.PROTEIN.GENERIC.SOS
member entity reference: Ras guanine nucleotide exchange factor A
member entity reference: Son of sevenless homolog 1
member entity reference: Protein son of sevenless
member entity reference: Ras guanine nucleotide exchange factor R
member entity reference: SOS Ras/Rho guanine nucleotide exchange factor 2
member entity reference: Uncharacterized protein
member entity reference: SOS Ras/Rac guanine nucleotide exchange factor 1
member entity reference: Ras guanine nucleotide exchange factor Y
member entity reference: Son of sevenless homolog 2
member entity reference: Ras guanine nucleotide exchange factor B

Gene transcription
type: Pathway

uniprot H2Q486 170
type: UnificationXref
id: H2Q486
db: uniprot

PTHR10614:SF13
type: RelationshipXref
id: PTHR10614:SF13
db: PANTHER Family
relationship type: By Homology

uniprot Q15349 183
type: UnificationXref
id: Q15349
db: uniprot

PTHR48013:SF8
type: RelationshipXref
id: PTHR48013:SF8
db: PANTHER Family
relationship type: By Homology

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F7BTW0 166
xref: PTHR24351:SF48
organism: Monodelphis domestica

PTHR23113:SF341
type: RelationshipXref
id: PTHR23113:SF341
db: PANTHER Family
relationship type: By Homology

uniprot H2QLB4 217
type: UnificationXref
id: H2QLB4
db: uniprot

PTHR10614:SF11
type: RelationshipXref
id: PTHR10614:SF11
db: PANTHER Family
relationship type: By Homology

ncbitaxon 321614 212
type: UnificationXref
id: 321614
db: ncbitaxon

Insulin-like growth factor II
type: ProteinReference
xref: PTHR46886:SF1
xref: uniprot P07456 50
organism: Bos taurus

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 207

Insulin-like growth factor I
type: ProteinReference
xref: uniprot P07455 49
organism: Bos taurus

PTHR48013:SF5
type: RelationshipXref
id: PTHR48013:SF5
db: PANTHER Family
relationship type: By Homology

uniprot F6V1C3 31
type: UnificationXref
id: F6V1C3
db: uniprot

Cation-independent mannose-6-phosphate receptor
type: ProteinReference
xref: uniprot Q07113 112
xref: PTHR15071:SF17
organism: Mus musculus

uniprot P23443 180
type: UnificationXref
id: P23443
db: uniprot

SOS
type: Protein
entity reference: SOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 334
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein kinase CTR1
type: ProteinReference
xref: uniprot Q05609 317
organism: Arabidopsis thaliana

Insulin IGF
type: Protein
entity reference: Insulin IGF
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa1 330
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F7GLY8 274
organism: Macaca mulatta

Insulin
type: ProteinReference
xref: uniprot P30410 63
organism: Pan troglodytes

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot A0A2I3RFV3 9
xref: PTHR24416:SF535
organism: Pan troglodytes

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot Q63932 289
xref: PTHR48013:SF8
organism: Mus musculus

ERK
type: Protein
entity reference: ERK
feature: ACTIVE 104
feature: ERK s25 a32 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6SWY2 107
type: UnificationXref
id: F6SWY2
db: uniprot

uniprot K7DH81 174
type: UnificationXref
id: K7DH81
db: uniprot

uniprot F1MAI3 73
type: UnificationXref
id: F1MAI3
db: uniprot

uniprot F1MQE1 155
type: UnificationXref
id: F1MQE1
db: uniprot

uniprot P35568 129
type: UnificationXref
id: P35568
db: uniprot

Insulin receptor substrate 4
type: ProteinReference
xref: uniprot O14654 127
xref: PTHR10614:SF2
organism: Homo sapiens

uniprot P18653 178
type: UnificationXref
id: P18653
db: uniprot

uniprot P39745 229
type: UnificationXref
id: P39745
db: uniprot

Insulin-like growth factor I
type: ProteinReference
xref: uniprot P08025 51
organism: Rattus norvegicus

uniprot P41969 258
type: UnificationXref
id: P41969
db: uniprot

uniprot P01346 45
type: UnificationXref
id: P01346
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot F6WX28 97
organism: Monodelphis domestica

uniprot O22558 312
type: UnificationXref
id: O22558
db: uniprot

uniprot F6UWI0 162
type: UnificationXref
id: F6UWI0
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q7ZVK8 247
organism: Danio rerio

Insulin-like growth factor II
type: ProteinReference
xref: uniprot P09535 55
xref: PTHR46886:SF1
organism: Mus musculus

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 222

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F6URW3 78
xref: PTHR23113:SF150
organism: Ornithorhynchus anatinus

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 54

uniprot P31938 279
type: UnificationXref
id: P31938
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F1P859 75
xref: PTHR23113:SF150
organism: Canis lupus familiaris

uniprot Q552M5 90
type: UnificationXref
id: Q552M5
db: uniprot

STATE_TRANSITION_LEFT__c_fos-RIGHT__c_fos-_r15
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 349
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 350
left: c-fos
interaction type: STATE_TRANSITION
right: c-fos

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot F6SJA3 29
xref: PTHR24416:SF106
organism: Monodelphis domestica

uniprot P27361 225
type: UnificationXref
id: P27361
db: uniprot

uniprot Q94AB2 322
type: UnificationXref
id: Q94AB2
db: uniprot

uniprot F6QUW1 77
type: UnificationXref
id: F6QUW1
db: uniprot

uniprot A0A1D5R6B6 7
type: UnificationXref
id: A0A1D5R6B6
db: uniprot

STATE_TRANSITION_LEFT__ELK-RIGHT__ELK-_r13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 354
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 353
left: ELK
interaction type: STATE_TRANSITION
right: ELK

Ras GTPase-activating protein 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot P50904 119
organism: Rattus norvegicus

uniprot Q9VR61 196
type: UnificationXref
id: Q9VR61
db: uniprot

uniprot Q9M1Z5 253
type: UnificationXref
id: Q9M1Z5
db: uniprot

uniprot F4JTP5 310
type: UnificationXref
id: F4JTP5
db: uniprot

Mitogen-activated protein kinase KSS1
type: ProteinReference
xref: uniprot P14681 221
organism: Saccharomyces cerevisiae

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF213
xref: uniprot F6UWI0 162
organism: Canis lupus familiaris

Raf s23 a21 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P28482 228
type: UnificationXref
id: P28482
db: uniprot

uniprot J9P5W6 275
type: UnificationXref
id: J9P5W6
db: uniprot

AT3g58640/F14P22_230
type: ProteinReference
xref: uniprot Q94AB2 322
organism: Arabidopsis thaliana

IRS1 isoform 1
type: ProteinReference
xref: PTHR10614:SF11
xref: uniprot H2QJJ4 126
organism: Pan troglodytes

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot A0A2I3S4A3 12
xref: PTHR24416:SF338
organism: Pan troglodytes

ncbitaxon 6239 186
type: UnificationXref
id: 6239
db: ncbitaxon

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: uniprot Q8BSK8 191
xref: PTHR24351:SF48
organism: Mus musculus

uniprot F7CQS0 167
type: UnificationXref
id: F7CQS0
db: uniprot

Insulin
type: ProteinReference
xref: uniprot A4IGV9 13
organism: Xenopus tropicalis

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q66JE6 290
organism: Xenopus tropicalis

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot Q6P023 244
organism: Danio rerio

ncbitaxon 9913 16
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot P24062 62
type: UnificationXref
id: P24062
db: uniprot

Sex muscle abnormal protein 5
type: ProteinReference
xref: uniprot P29355 294
xref: PTHR46037:SF1
organism: Caenorhabditis elegans

Insulin
type: ProteinReference
xref: uniprot O73727 34
organism: Danio rerio

uniprot A0A1D5QB09 120
type: UnificationXref
id: A0A1D5QB09
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 14

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q9XT09 292
organism: Pan troglodytes

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF41
xref: uniprot K7BI90 173
organism: Pan troglodytes

uniprot O75582 175
type: UnificationXref
id: O75582
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9LQQ9 252
organism: Arabidopsis thaliana

uniprot Q8BSK8 191
type: UnificationXref
id: Q8BSK8
db: uniprot

uniprot P26675 84
type: UnificationXref
id: P26675
db: uniprot

uniprot A0A2I3S4A3 12
type: UnificationXref
id: A0A2I3S4A3
db: uniprot

uniprot A0A3Q1MLN6 142
type: UnificationXref
id: A0A3Q1MLN6
db: uniprot

uniprot A0A3S5ZPX3 263
type: UnificationXref
id: A0A3S5ZPX3
db: uniprot

Insulin-like growth factor 1 receptor
type: ProteinReference
xref: uniprot P08069 52
xref: PTHR24416:SF106
organism: Homo sapiens

uniprot Q02750 284
type: UnificationXref
id: Q02750
db: uniprot

ACTIVE 104
type: EntityFeature
comment: Active state

Evidence 304
type: Evidence
evidence code: ISS
comment: SPACC Q99N57

Evidence 303
type: Evidence
evidence code: ISS
comment: SPACC P11345

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A1D5QL06 137
xref: PTHR24351:SF98
organism: Macaca mulatta

Evidence 302
type: Evidence
evidence code: ISS
comment: SPACC P05625

Evidence 301
type: Evidence
evidence code: ISS
comment: SPACC P04049

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__P90_RSK-RIGHT__P90_RSK-_r14
controller: ERK

uniprot D4A3T0 72
type: UnificationXref
id: D4A3T0
db: uniprot

uniprot Q7PVR1 246
type: UnificationXref
id: Q7PVR1
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q9FXT7 249
organism: Chlamydomonas reinhardtii

c-fos
type: ProteinReference
xref: P00884
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade.PROTEIN.GENERIC.c_minus_fos
comment: ENTITY_REFERENCE_NOTES=Long Name: c-fos Synonym: Synonym not specified Accession: P00884
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Proto-oncogene c-Fos
member entity reference: Fos proto-oncogene, AP-1 transcription factor subunit
member entity reference: C-fos
member entity reference: V-fos FBJ murine osteosarcoma viral oncogene homolog
member entity reference: Uncharacterized protein
member entity reference: FBJ murine osteosarcoma viral oncogene homolog

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: c-fos

HETERODIMER_ASSOCIATION_LEFT__Grb2-_SOS-RIGHT__Complex__SOS_Grb2_-_r5
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 338
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 337
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 339
left: SOS
left: Grb2
interaction type: HETERODIMER_ASSOCIATION
right: Complex (SOS/Grb2)

Insulin-like growth factor 2
type: ProteinReference
xref: uniprot Q8JIE4 69
xref: PTHR46886:SF1
organism: Danio rerio

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot J9P5W6 275
xref: PTHR48013:SF5
organism: Canis lupus familiaris

MAP2K1 protein
type: ProteinReference
xref: uniprot Q0VD16 285
xref: PTHR48013:SF5
organism: Bos taurus

MEK s16 a26 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F6QUW1 77
organism: Monodelphis domestica

uniprot Q9NAH6 192
type: UnificationXref
id: Q9NAH6
db: uniprot

uniprot P07456 50
type: UnificationXref
id: P07456
db: uniprot

Dual specificity mitogen-activated protein kinase kinase dSOR1
type: ProteinReference
xref: uniprot Q24324 287
xref: PTHR48013:SF19
organism: Drosophila melanogaster

uniprot P18654 179
type: UnificationXref
id: P18654
db: uniprot

Fos proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot E2QYK5 96
organism: Canis lupus familiaris

PTHR24351:SF110
type: RelationshipXref
id: PTHR24351:SF110
db: PANTHER Family
relationship type: By Homology

ncbitaxon 237631 201
type: UnificationXref
id: 237631
db: ncbitaxon

uniprot E1BN61 150
type: UnificationXref
id: E1BN61
db: uniprot

PTHR24351:SF115
type: RelationshipXref
id: PTHR24351:SF115
db: PANTHER Family
relationship type: By Homology

MAP2K2 isoform 1
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot K7BYT0 276
organism: Pan troglodytes

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF115
xref: uniprot E1BN61 150
organism: Bos taurus

uniprot F7BD74 273
type: UnificationXref
id: F7BD74
db: uniprot

Insulin receptor substrate 1
type: ProteinReference
xref: PTHR10614:SF11
xref: uniprot E2RDB5 122
organism: Canis lupus familiaris

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot P31938 279
organism: Mus musculus

uniprot P05625 315
type: UnificationXref
id: P05625
db: uniprot

uniprot A0A2I3TPM9 139
type: UnificationXref
id: A0A2I3TPM9
db: uniprot

ncbitaxon 7739 19
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot Q6TJY3 188
type: UnificationXref
id: Q6TJY3
db: uniprot

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot B0R0Q2 17
xref: PTHR24416:SF106
organism: Danio rerio

PTHR48013:SF15
type: RelationshipXref
id: PTHR48013:SF15
db: PANTHER Family
relationship type: By Homology

MEK
type: ProteinReference
xref: P00891
standard name: Mitogen-activated protein kinase kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade.PROTEIN.GENERIC.MEK
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen-activated protein kinase kinase Synonym: MAP kinase kinase,MAP/ERK kinase,MAPKK,Mitogen-activated ERK activating kinase Accession: P00891
member entity reference: Dual specificity mitogen-activated protein kinase kinase 1
member entity reference: MAP2K1 protein
member entity reference: Uncharacterized protein
member entity reference: Map2k3 protein
member entity reference: Mitogen-activated protein kinase kinase 3
member entity reference: Dual specificity mitogen-activated protein kinase kinase dSOR1
member entity reference: Mitogen-activated protein kinase kinase 1
member entity reference: Dual specificity mitogen-activated protein kinase kinase 2
member entity reference: Mitogen-activated protein kinase kinase 4A
member entity reference: MAP kinase kinase 4, isoform A
member entity reference: AGAP000310-PA
member entity reference: Mitogen-activated protein kinase kinase 4
member entity reference: Dual specificity mitogen-activated protein kinase kinase 3
member entity reference: MAP2K2 isoform 1
member entity reference: Mitogen-activated protein kinase kinase 2
member entity reference: Dual-specificity mitogen-activated protein kinase kinase 2

Insulin receptor-related protein
type: ProteinReference
xref: uniprot P14616 56
xref: PTHR24416:SF338
organism: Homo sapiens

PTHR48013:SF19
type: RelationshipXref
id: PTHR48013:SF19
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r7 363
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF110
xref: uniprot Q7QDB4 189
organism: Anopheles gambiae

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E1B8P9 208
xref: PTHR24055:SF393
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r7 364
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

ncbitaxon 9258 26
type: UnificationXref
id: 9258
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r7 365
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

uniprot P18254 60
type: UnificationXref
id: P18254
db: uniprot

PARTICIPANT STOICHIOMETRY r7 366
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

eco ECO:0000305 268
type: UnificationXref
id: ECO:0000305
db: eco

Bos taurus
type: BioSource
xref: ncbitaxon 9913 16

uniprot P63085 230
type: UnificationXref
id: P63085
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot K7CZM1 83
xref: PTHR23113:SF150
organism: Pan troglodytes

PTHR24351:SF171
type: RelationshipXref
id: PTHR24351:SF171
db: PANTHER Family
relationship type: By Homology

uniprot V5IKE7 254
type: UnificationXref
id: V5IKE7
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 26

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot H2Q486 170
organism: Pan troglodytes

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: uniprot P23443 180
xref: PTHR24351:SF48
organism: Homo sapiens

Insulin receptor substrate 4
type: ProteinReference
xref: uniprot F6YCQ0 124
xref: PTHR10614:SF2
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ELK-RIGHT__ELK-_r13
controller: ERK

PTHR48013:SF21
type: RelationshipXref
id: PTHR48013:SF21
db: PANTHER Family
relationship type: By Homology

uniprot Q54PQ4 88
type: UnificationXref
id: Q54PQ4
db: uniprot

AT4G31170 protein
type: ProteinReference
xref: uniprot Q9M085 327
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r11 358
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 357
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 356
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 355
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A2I3TPM9 139
xref: PTHR24351:SF43
organism: Pan troglodytes

PTHR24416:SF535
type: RelationshipXref
id: PTHR24416:SF535
db: PANTHER Family
relationship type: By Homology

uniprot Q9FPR3 326
type: UnificationXref
id: Q9FPR3
db: uniprot

Cation-independent mannose-6-phosphate receptor
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot P11717 111
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7E823 213
organism: Monodelphis domestica

uniprot P14616 56
type: UnificationXref
id: P14616
db: uniprot

PTHR15071:SF17
type: RelationshipXref
id: PTHR15071:SF17
db: PANTHER Family
relationship type: By Homology

Insulin receptor
type: ProteinReference
xref: uniprot P15208 58
xref: PTHR24416:SF535
organism: Mus musculus

Insulin receptor substrate 2
type: ProteinReference
xref: uniprot Q9Y4H2 133
xref: PTHR10614:SF7
organism: Homo sapiens

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 21

uniprot F1MC23 23
type: UnificationXref
id: F1MC23
db: uniprot

uniprot A0A2I3S8A4 138
type: UnificationXref
id: A0A2I3S8A4
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F1MAI3 73
xref: PTHR23113:SF150
organism: Rattus norvegicus

IRS 1-4
type: ProteinReference
xref: P00887
standard name: Insulin receptor substrate family
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Insulin receptor substrate family Synonym: IRS Accession: P00887
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade.PROTEIN.GENERIC.IRS_space_1_minus_4
member entity reference: Insulin receptor substrate 2
member entity reference: Insulin receptor substrate 1
member entity reference: Uncharacterized protein
member entity reference: IRS1 isoform 1
member entity reference: Insulin receptor substrate 3, isoform CRA_a (Fragment)
member entity reference: Insulin receptor substrate 4
member entity reference: Insulin receptor substrate 3

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot E2RMD8 152
xref: PTHR24351:SF48
organism: Canis lupus familiaris

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 61

Insulin-like growth factor 1 receptor
type: ProteinReference
xref: uniprot Q60751 67
xref: PTHR24416:SF106
organism: Mus musculus

uniprot F7E823 213
type: UnificationXref
id: F7E823
db: uniprot

uniprot A0A1D5QL06 137
type: UnificationXref
id: A0A1D5QL06
db: uniprot

uniprot F6S9S9 271
type: UnificationXref
id: F6S9S9
db: uniprot

PTHR46886:SF1
type: RelationshipXref
id: PTHR46886:SF1
db: PANTHER Family
relationship type: By Homology

ELK
type: Protein
entity reference: ELK
feature: ELK s18 a36 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Ribosomal protein S6 kinase beta
type: ProteinReference
xref: uniprot Q9NAH6 192
organism: Caenorhabditis elegans

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7EH19 214
xref: PTHR24055:SF203
organism: Xenopus tropicalis

PAS domain-containing protein tyrosine kinase family protein
type: ProteinReference
xref: uniprot F4JC18 308
organism: Arabidopsis thaliana

uniprot A0A1D5NWT4 135
type: UnificationXref
id: A0A1D5NWT4
db: uniprot

Insulin-like growth factor 2a
type: ProteinReference
xref: PTHR46886:SF1
xref: uniprot Q5U3B4 66
organism: Danio rerio

uniprot Q7ZVK8 247
type: UnificationXref
id: Q7ZVK8
db: uniprot

uniprot P04049 314
type: UnificationXref
id: P04049
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10614:SF11
xref: uniprot A0A1D5QB09 120
organism: Macaca mulatta

uniprot Q39023 236
type: UnificationXref
id: Q39023
db: uniprot

Tyrosine-protein kinase receptor
type: ProteinReference
xref: PTHR24416:SF525
xref: uniprot C4A0B6 18
organism: Branchiostoma floridae

PTHR24416:SF525
type: RelationshipXref
id: PTHR24416:SF525
db: PANTHER Family
relationship type: By Homology

uniprot P15127 57
type: UnificationXref
id: P15127
db: uniprot

uniprot Q5RKN6 296
type: UnificationXref
id: Q5RKN6
db: uniprot

Insulin receptor substrate 4
type: ProteinReference
xref: uniprot Q9Z0Y7 134
xref: PTHR10614:SF2
organism: Mus musculus

Ribosomal protein S6 kinase alpha-3
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot P51812 181
organism: Homo sapiens

ncbitaxon 3702 220
type: UnificationXref
id: 3702
db: ncbitaxon

Ribosomal protein S6 kinase alpha-1
type: ProteinReference
xref: uniprot Q15418 184
xref: PTHR24351:SF43
organism: Homo sapiens

uniprot P33717 64
type: UnificationXref
id: P33717
db: uniprot

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot Q02384 85
xref: PTHR23113:SF150
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_MEK-RIGHT__MEK-_ADP-_r9
controller: Raf

Ras GTPase-activating protein 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot P20936 118
organism: Homo sapiens

Probable serine/threonine-protein kinase SIS8
type: ProteinReference
xref: uniprot Q9C9U5 324
organism: Arabidopsis thaliana

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF41
xref: uniprot F6SDH6 158
organism: Macaca mulatta

Insulin-like growth factor 2 receptor
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot G3V824 108
organism: Rattus norvegicus

uniprot Q24324 287
type: UnificationXref
id: Q24324
db: uniprot

PARTICIPANT STOICHIOMETRY r15 349
type: Stoichiometry
physical entity: c-fos
stoichiometric coefficient: 1.0

uniprot Q9ZQ31 328
type: UnificationXref
id: Q9ZQ31
db: uniprot

Grb2
type: Protein
entity reference: Grb2
feature: ACTIVE 104
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot E2R7K9 151
type: UnificationXref
id: E2R7K9
db: uniprot

PARTICIPANT STOICHIOMETRY r15 350
type: Stoichiometry
physical entity: c-fos
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot F6ZM17 165
organism: Xenopus tropicalis

AGAP000310-PA
type: ProteinReference
xref: uniprot Q7PRZ7 291
organism: Anopheles gambiae

Grb2
type: Protein
entity reference: Grb2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 233

uniprot F6UNV6 161
type: UnificationXref
id: F6UNV6
db: uniprot

uniprot P08025 51
type: UnificationXref
id: P08025
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF41
xref: uniprot D3ZSB7 147
organism: Rattus norvegicus

uniprot F7DNM3 115
type: UnificationXref
id: F7DNM3
db: uniprot

ERK
type: ProteinReference
xref: P00889
standard name: Mitogen-activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen-activated protein kinase Synonym: Extracellular signal-regulated kinase,MAP kinase,MAPK Accession: P00889
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade.PROTEIN.GENERIC.ERK
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase KSS1
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Mitogen-activated protein kinase 4
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase 2
member entity reference: Extracellular signal-regulated kinase 1
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase 5
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase spk1
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Mitogen-activated protein kinase (Fragment)
member entity reference: Mitogen-activated protein kinase 10
member entity reference: Mitogen-activated protein kinase FUS3
member entity reference: Mitogen-activated protein kinase 6
member entity reference: Mitogen-activated protein kinase 7
member entity reference: Mitogen-activated protein kinase mpk-1

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF98
xref: uniprot A0A2I3S8A4 138
organism: Pan troglodytes

uniprot A8XFY3 144
type: UnificationXref
id: A8XFY3
db: uniprot

uniprot F6VZY3 32
type: UnificationXref
id: F6VZY3
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 190

Grb2
type: ProteinReference
xref: P00892
standard name: Growth factor receptor-bound protein 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade.PROTEIN.GENERIC.Grb2
comment: ENTITY_REFERENCE_NOTES=Long Name: Growth factor receptor bound protein 2 Synonym: ASH protein,Abundant Src homology,Grb2 Accession: P00892
member entity reference: Protein enhancer of sevenless 2B
member entity reference: Sex muscle abnormal protein 5
member entity reference: Growth factor receptor-bound protein 2a
member entity reference: Growth factor receptor-bound protein 2
member entity reference: Protein CBR-SEM-5

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot H2QDK7 171
xref: PTHR24351:SF48
organism: Pan troglodytes

uniprot Q9FXT7 249
type: UnificationXref
id: Q9FXT7
db: uniprot

uniprot Q9C9U5 324
type: UnificationXref
id: Q9C9U5
db: uniprot

uniprot P08169 110
type: UnificationXref
id: P08169
db: uniprot

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot P01101 101
organism: Mus musculus

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot P01100 100
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot A0A1D5QKD3 261
organism: Macaca mulatta

IRS 1 4 s7 a7 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q9LQQ9 252
type: UnificationXref
id: Q9LQQ9
db: uniprot

IGF1 isoform 4
type: ProteinReference
xref: uniprot A0A2I3RUB7 11
organism: Pan troglodytes

uniprot C4A0B6 18
type: UnificationXref
id: C4A0B6
db: uniprot

uniprot A0A1D5Q3X8 136
type: UnificationXref
id: A0A1D5Q3X8
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot H2R8U9 81
xref: PTHR23113:SF168
organism: Pan troglodytes

Ribosomal protein S6 kinase alpha-4
type: ProteinReference
xref: uniprot Q9Z2B9 199
xref: PTHR24351:SF41
organism: Mus musculus

uniprot P09208 53
type: UnificationXref
id: P09208
db: uniprot

P90 RSK
type: Protein
entity reference: P90 RSK
feature: ACTIVE 104
feature: P90 RSK s27 a40 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PANTHER Pathway P00032 1
type: UnificationXref
id: P00032
db: PANTHER Pathway

c-fos
type: Protein
entity reference: c-fos
feature: c fos s20 a42 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

IRS 1 4 s22 a8 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q05609 317
type: UnificationXref
id: Q05609
db: uniprot

Grb2
type: Protein
entity reference: Grb2
feature: ACTIVE 104
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa4 336
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot E2R795 20
xref: PTHR24416:SF338
organism: Canis lupus familiaris

uniprot A0A1D5QUZ8 203
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot H9FYU7 82
xref: PTHR23113:SF150
organism: Macaca mulatta

c fos s28 a43 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P11717 111
type: UnificationXref
id: P11717
db: uniprot

uniprot F7H7W3 169
type: UnificationXref
id: F7H7W3
db: uniprot

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot Q86HG9 318
type: UnificationXref
id: Q86HG9
db: uniprot

ELK s26 a37 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot A0A0R4IGP2 3
xref: PTHR24416:SF106
organism: Danio rerio

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A1D5Q3X8 136
xref: PTHR24351:SF115
organism: Macaca mulatta

c-fos
type: Protein
entity reference: c-fos
feature: ACTIVE 104
feature: c fos s28 a43 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 559292 222
type: UnificationXref
id: 559292
db: ncbitaxon

Insulin-like growth factor I
type: ProteinReference
xref: uniprot P05019 47
organism: Homo sapiens

PTHR24351:SF98
type: RelationshipXref
id: PTHR24351:SF98
db: PANTHER Family
relationship type: By Homology

Insulin-like growth factor I
type: ProteinReference
xref: uniprot P05017 46
organism: Mus musculus

STATE_TRANSITION_LEFT__ATP-_IRS_1_4-RIGHT__IRS_1_4-_ADP-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 343
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 342
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 344
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 345
left: ATP
left: IRS 1-4
interaction type: STATE_TRANSITION
right: ADP
right: IRS 1-4

PARTICIPANT STOICHIOMETRY r2 345
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 344
type: Stoichiometry
physical entity: IRS 1-4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 343
type: Stoichiometry
physical entity: IRS 1-4
stoichiometric coefficient: 1.0

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 227

PARTICIPANT STOICHIOMETRY r2 342
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot A0A0D1C4Y4 200
type: UnificationXref
id: A0A0D1C4Y4
db: uniprot

uniprot P14681 221
type: UnificationXref
id: P14681
db: uniprot

ELK
type: Protein
entity reference: ELK
feature: ACTIVE 104
feature: ELK s26 a37 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F6TPX7 159
xref: PTHR24351:SF48
organism: Ornithorhynchus anatinus

PTHR11849:SF133
type: RelationshipXref
id: PTHR11849:SF133
db: PANTHER Family
relationship type: By Homology

Insulin IGF s6 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Insulin IGF
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7FHD1 216
organism: Monodelphis domestica

ERK s17 a31 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Chromosomal serine/threonine-protein kinase JIL-1
type: ProteinReference
xref: uniprot Q9V3I5 195
organism: Drosophila melanogaster

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: uniprot Q6TJY3 188
xref: PTHR24351:SF48
organism: Bos taurus

uniprot P46734 282
type: UnificationXref
id: P46734
db: uniprot

uniprot P01322 38
type: UnificationXref
id: P01322
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot D4AE24 148
organism: Rattus norvegicus

uniprot P12841 102
type: UnificationXref
id: P12841
db: uniprot

uniprot P36506 280
type: UnificationXref
id: P36506
db: uniprot

uniprot P50904 119
type: UnificationXref
id: P50904
db: uniprot

uniprot Q9Z0Y7 134
type: UnificationXref
id: Q9Z0Y7
db: uniprot

RAS p21 protein activator 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot F7EPN2 116
organism: Ornithorhynchus anatinus

RAS p21 protein activator (GTPase activating protein) 1
type: ProteinReference
xref: uniprot H2QR74 117
xref: PTHR10194:SF19
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VZY3 32
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot F5HEA9 211
organism: Phaeosphaeria nodorum

uniprot Q9XT09 292
type: UnificationXref
id: Q9XT09
db: uniprot

uniprot E2R795 20
type: UnificationXref
id: E2R795
db: uniprot

Insulin-like growth factor II
type: ProteinReference
xref: PTHR46886:SF1
xref: uniprot P01346 45
organism: Rattus norvegicus

Insulin-like growth factor II
type: ProteinReference
xref: PTHR46886:SF1
xref: uniprot P01344 44
organism: Homo sapiens

STATE_TRANSITION_LEFT__ATP-_Raf-RIGHT__Raf-_ADP-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 365
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 364
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 363
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 366
left: Raf
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: Raf

P00883
type: UnificationXref
id: P00883
db: PANTHER Pathway Component

uniprot P01308 35
type: UnificationXref
id: P01308
db: uniprot

P00882
type: UnificationXref
id: P00882
db: PANTHER Pathway Component

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 304
xref: PTHR44329:SF22
xref: uniprot Q99N57 323
organism: Mus musculus

ETS domain-containing protein Elk-1
type: ProteinReference
xref: uniprot P19419 257
xref: PTHR11849:SF178
organism: Homo sapiens

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 36

uniprot Q9WTL4 71
type: UnificationXref
id: Q9WTL4
db: uniprot

uniprot Q9LMM5 251
type: UnificationXref
id: Q9LMM5
db: uniprot

Insulin IGF
type: ProteinReference
xref: P00882
standard name: Insulin/Insulin like growth factor
comment: ENTITY_REFERENCE_NOTES=Long Name: Insulin/Insulin like growth factor Synonym: IGF,IGF1,IGF2,Insulin like growth factor 1,Insulin like growth factor 2 Accession: P00882
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade.PROTEIN.GENERIC.Insulin_br_IGF
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Insulin
member entity reference: Insulin-like growth factor I
member entity reference: Insulin-like growth factor 1 receptor
member entity reference: Tyrosine-protein kinase receptor
member entity reference: Insulin-2
member entity reference: Insulin-1
member entity reference: Insulin-like growth factor 1
member entity reference: Insulin-like growth factor II
member entity reference: Insulin receptor
member entity reference: Insulin-like growth factor 2
member entity reference: IGF1 isoform 4
member entity reference: Insulin-like growth factor 2a
member entity reference: Insulin like growth factor 1
member entity reference: Insulin-like receptor
member entity reference: Insulin receptor-related protein
member entity reference: Uncharacterized protein

uniprot P67999 182
type: UnificationXref
id: P67999
db: uniprot

P00888
type: UnificationXref
id: P00888
db: PANTHER Pathway Component

ncbitaxon 13616 30
type: UnificationXref
id: 13616
db: ncbitaxon

Ribosomal protein S6 kinase alpha-4
type: ProteinReference
xref: PTHR24351:SF41
xref: uniprot O75676 176
organism: Homo sapiens

P00889
type: UnificationXref
id: P00889
db: PANTHER Pathway Component

uniprot A0A3Q1LXK8 141
type: UnificationXref
id: A0A3Q1LXK8
db: uniprot

P00886
type: UnificationXref
id: P00886
db: PANTHER Pathway Component

P00887
type: UnificationXref
id: P00887
db: PANTHER Pathway Component

P00884
type: UnificationXref
id: P00884
db: PANTHER Pathway Component

P00885
type: UnificationXref
id: P00885
db: PANTHER Pathway Component

uniprot F6XT65 272
type: UnificationXref
id: F6XT65
db: uniprot

P00893
type: UnificationXref
id: P00893
db: PANTHER Pathway Component

P00892
type: UnificationXref
id: P00892
db: PANTHER Pathway Component

uniprot P30410 63
type: UnificationXref
id: P30410
db: uniprot

ncbitaxon 3055 250
type: UnificationXref
id: 3055
db: ncbitaxon

P00891
type: UnificationXref
id: P00891
db: PANTHER Pathway Component

P00890
type: UnificationXref
id: P00890
db: PANTHER Pathway Component

PTHR24351:SF41
type: RelationshipXref
id: PTHR24351:SF41
db: PANTHER Family
relationship type: By Homology

PTHR24351:SF43
type: RelationshipXref
id: PTHR24351:SF43
db: PANTHER Family
relationship type: By Homology

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 260

PTHR24351:SF48
type: RelationshipXref
id: PTHR24351:SF48
db: PANTHER Family
relationship type: By Homology

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot Q1HG70 286
xref: PTHR48013:SF8
organism: Canis lupus familiaris

uniprot F7FRY0 168
type: UnificationXref
id: F7FRY0
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot Q84UI5 248
organism: Oryza sativa

uniprot A5A6H0 94
type: UnificationXref
id: A5A6H0
db: uniprot

FBJ murine osteosarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot F7EI91 98
organism: Xenopus tropicalis

uniprot F6PXH5 270
type: UnificationXref
id: F6PXH5
db: uniprot

Insulin
type: ProteinReference
xref: uniprot P01321 37
organism: Canis lupus familiaris

Insulin-1
type: ProteinReference
xref: uniprot P01322 38
organism: Rattus norvegicus

uniprot P01100 100
type: UnificationXref
id: P01100
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot V5IKE7 254
organism: Neurospora crassa

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot A0A1D5NWT4 135
organism: Gallus gallus

Insulin-1
type: ProteinReference
xref: uniprot P01325 41
organism: Mus musculus

Insulin-2
type: ProteinReference
xref: uniprot P01326 43
organism: Mus musculus

Insulin-2
type: ProteinReference
xref: uniprot P01323 40
organism: Rattus norvegicus

uniprot Q5A1D3 240
type: UnificationXref
id: Q5A1D3
db: uniprot

uniprot Q8LQ53 319
type: UnificationXref
id: Q8LQ53
db: uniprot

PTHR24351:SF58
type: RelationshipXref
id: PTHR24351:SF58
db: PANTHER Family
relationship type: By Homology

uniprot A7F3M0 204
type: UnificationXref
id: A7F3M0
db: uniprot

uniprot Q6PC73 298
type: UnificationXref
id: Q6PC73
db: uniprot

uniprot Q39021 234
type: UnificationXref
id: Q39021
db: uniprot

uniprot C8V7D1 206
type: UnificationXref
id: C8V7D1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6S9S9 271
xref: PTHR48013:SF8
organism: Monodelphis domestica

uniprot A8XPY6 293
type: UnificationXref
id: A8XPY6
db: uniprot

Insulin-like growth factor 1 receptor
type: ProteinReference
xref: uniprot P24062 62
xref: PTHR24416:SF106
organism: Rattus norvegicus

uniprot Q39022 235
type: UnificationXref
id: Q39022
db: uniprot

Insulin
type: ProteinReference
xref: uniprot P01308 35
organism: Homo sapiens

uniprot Q02384 85
type: UnificationXref
id: Q02384
db: uniprot

uniprot Q21734 185
type: UnificationXref
id: Q21734
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot A0A1D5QUZ8 203
organism: Macaca mulatta

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF110
xref: uniprot Q9VR61 196
organism: Drosophila melanogaster

PTHR11849:SF178
type: RelationshipXref
id: PTHR11849:SF178
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r6 368
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PTHR24055:SF158
type: RelationshipXref
id: PTHR24055:SF158
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r6 367
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 89

uniprot Q10N20 232
type: UnificationXref
id: Q10N20
db: uniprot

Complex (Insulin IGF/INSR IGF-R IRR)
type: Complex
component stoichiometry: Insulin IGF s6 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: INSR IGF R IRR s10 sa2 STOICHIOMETRY ID COMPLEX
component: INSR IGF-R IRR
component: Insulin IGF
feature: COMPLEX BINDING FEATURE s5 a5 329
feature: COMPLEX BINDING FEATURE s5 a5 331
cellular location: cytosol

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot F6SJA3 29
type: UnificationXref
id: F6SJA3
db: uniprot

P90 RSK
type: Protein
entity reference: P90 RSK
feature: P90 RSK s19 a39 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 268

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 59

uniprot B0R0Q2 17
type: UnificationXref
id: B0R0Q2
db: uniprot

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot P67999 182
organism: Rattus norvegicus

Mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot A0A3S5ZPX3 263
xref: PTHR48013:SF8
organism: Bos taurus

eco ECO:0000250 5
type: UnificationXref
id: ECO:0000250
db: eco

uniprot A4IGV9 13
type: UnificationXref
id: A4IGV9
db: uniprot

uniprot H2R8U9 81
type: UnificationXref
id: H2R8U9
db: uniprot

Serine/threonine-protein kinase EDR1
type: ProteinReference
xref: uniprot Q9FPR3 326
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q6Z437 245
organism: Oryza sativa

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F7BD74 273
organism: Monodelphis domestica

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF213
xref: uniprot A0A3Q1LNQ6 140
organism: Bos taurus

uniprot F7BTW0 166
type: UnificationXref
id: F7BTW0
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot H2QLB4 217
organism: Pan troglodytes

PAS domain-containing protein tyrosine kinase family protein
type: ProteinReference
xref: uniprot F4HVH9 307
organism: Arabidopsis thaliana

Insulin-like receptor
type: ProteinReference
xref: PTHR24416:SF525
xref: uniprot P09208 53
organism: Drosophila melanogaster

uniprot Q95UJ1 259
type: UnificationXref
id: Q95UJ1
db: uniprot

uniprot D3Z8E0 146
type: UnificationXref
id: D3Z8E0
db: uniprot

uniprot Q62245 91
type: UnificationXref
id: Q62245
db: uniprot

uniprot O54718 128
type: UnificationXref
id: O54718
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot A0A1D5Q5Z6 202
organism: Macaca mulatta

Complex (SOS/Grb2)
type: Complex
component stoichiometry: SOS s3 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: Grb2 s4 sa4 STOICHIOMETRY ID COMPLEX
component: SOS
component: Grb2
feature: COMPLEX BINDING FEATURE s13 a17 335
feature: COMPLEX BINDING FEATURE s13 a17 333
cellular location: cytosol

uniprot H9FYU7 82
type: UnificationXref
id: H9FYU7
db: uniprot

Insulin
type: ProteinReference
xref: uniprot P67970 65
organism: Gallus gallus

uniprot F4JQX7 309
type: UnificationXref
id: F4JQX7
db: uniprot

uniprot Q66JE6 290
type: UnificationXref
id: Q66JE6
db: uniprot

uniprot K7B5K7 109
type: UnificationXref
id: K7B5K7
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

Insulin IGF
type: Protein
entity reference: Insulin IGF
comment: SPECIES_TYPE=PROTEIN

uniprot P06213 48
type: UnificationXref
id: P06213
db: uniprot

uniprot Q5Z859 242
type: UnificationXref
id: Q5Z859
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF98
xref: uniprot A0A3Q1LXK8 141
organism: Bos taurus

uniprot Q9UK32 194
type: UnificationXref
id: Q9UK32
db: uniprot

uniprot Q39024 237
type: UnificationXref
id: Q39024
db: uniprot

uniprot E2RMD8 152
type: UnificationXref
id: E2RMD8
db: uniprot

RAS p21 protein activator 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot E9PYG6 113
organism: Mus musculus

Candida albicans
type: BioSource
xref: ncbitaxon 237561 241

Insulin receptor-related protein
type: ProteinReference
xref: uniprot Q9WTL4 71
xref: PTHR24416:SF338
organism: Mus musculus

Extracellular signal-regulated kinase 1
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot Q5A1D3 240
organism: Candida albicans

C-fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot A5A6H0 94
organism: Pan troglodytes

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

C-fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot A5A6H2 95
organism: Macaca mulatta

uniprot O82754 313
type: UnificationXref
id: O82754
db: uniprot

Insulin receptor substrate 1
type: ProteinReference
xref: PTHR10614:SF11
xref: uniprot P35569 130
organism: Mus musculus

Insulin receptor substrate 1
type: ProteinReference
xref: PTHR10614:SF11
xref: uniprot P35568 129
organism: Homo sapiens

uniprot P07455 49
type: UnificationXref
id: P07455
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot A7F3M0 204
organism: Sclerotinia sclerotiorum

STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 368
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 367
left: Ras
interaction type: STATE_TRANSITION
right: Ras

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 212

uniprot E2RPM8 22
type: UnificationXref
id: E2RPM8
db: uniprot

ncbitaxon 6238 145
type: UnificationXref
id: 6238
db: ncbitaxon

MEK
type: Protein
entity reference: MEK
feature: MEK s16 a26 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P51812 181
type: UnificationXref
id: P51812
db: uniprot

uniprot F1LP57 266
type: UnificationXref
id: F1LP57
db: uniprot

uniprot Q39027 239
type: UnificationXref
id: Q39027
db: uniprot

Insulin receptor substrate 1
type: ProteinReference
xref: PTHR10614:SF11
xref: uniprot P35570 131
organism: Rattus norvegicus

P90 RSK
type: ProteinReference
xref: P00888
standard name: Ribosomal protein S6 kinase, 90kD
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: 90 kDa ribosomal protein S6 kinase Synonym: Synonym not specified Accession: P00888
comment: ENTITY_REFERENCE_ID_DESC=Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade.PROTEIN.GENERIC.P90_space_RSK
member entity reference: Ribosomal protein S6 kinase
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: Ribosomal protein S6 kinase alpha-6
member entity reference: Ribosomal protein S6 kinase beta-1
member entity reference: Ribosomal protein S6 kinase beta-2
member entity reference: Ribosomal protein S6 kinase beta
member entity reference: Ribosomal protein S6 kinase alpha-5
member entity reference: Ribosomal protein S6 kinase alpha-4
member entity reference: Ribosomal protein S6 kinase 2 alpha
member entity reference: Putative ribosomal protein S6 kinase alpha-1
member entity reference: Chromosomal serine/threonine-protein kinase JIL-1
member entity reference: Ribosomal protein S6 kinase alpha-1
member entity reference: Ribosomal protein S6 kinase alpha-2
member entity reference: Ribosomal protein S6 kinase alpha-3

Ras guanine nucleotide exchange factor Y
type: ProteinReference
xref: uniprot Q552M5 90
organism: Dictyostelium discoideum

uniprot Q60631 297
type: UnificationXref
id: Q60631
db: uniprot

uniprot F6TPX7 159
type: UnificationXref
id: F6TPX7
db: uniprot

uniprot P05017 46
type: UnificationXref
id: P05017
db: uniprot