Ras family GTPase
type: ProteinReference
xref: PTHR24070:SF263
xref: uniprot C4M8B0 17
organism: Entamoeba histolytica

Alpha-actinin-1
type: ProteinReference
xref: PTHR11915:SF434
xref: uniprot Q9Z1P2 744
organism: Rattus norvegicus

uniprot Q7ZUQ0 243
type: UnificationXref
id: Q7ZUQ0
db: uniprot

PARTICIPANT STOICHIOMETRY r106 1606
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r106 1607
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot E2QVF3 100
xref: PTHR24055:SF171
organism: Canis lupus familiaris

uniprot E2RNQ7 594
type: UnificationXref
id: E2RNQ7
db: uniprot

Rac
type: Protein
entity reference: Rac
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR10574:SF261
type: RelationshipXref
id: PTHR10574:SF261
db: PANTHER Family
relationship type: By Homology

uniprot A7E303 416
type: UnificationXref
id: A7E303
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot F6SZ66 890
xref: PTHR10048:SF7
organism: Monodelphis domestica

uniprot E2RIF9 881
type: UnificationXref
id: E2RIF9
db: uniprot

Vinculin
type: ProteinReference
xref: PTHR46180:SF1
xref: uniprot P85972 960
organism: Rattus norvegicus

PTHR10574:SF268
type: RelationshipXref
id: PTHR10574:SF268
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A452DI16 629
xref: PTHR44329:SF55
organism: Bos taurus

Focal adhesion kinase 1
type: ProteinReference
xref: PTHR24418:SF78
xref: uniprot P34152 828
organism: Mus musculus

uniprot Q07092 551
type: UnificationXref
id: Q07092
db: uniprot

Vinculin s87 sa96 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Vinculin
stoichiometric coefficient: 1.0

uniprot H2R464 779
type: UnificationXref
id: H2R464
db: uniprot

uniprot O88207 497
type: UnificationXref
id: O88207
db: uniprot

Arp2/3
type: Protein
entity reference: Arp2/3
feature: COMPLEX PARTICIPANT BINDING FEATURE s89 sa98 1506
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot K7CFQ9 130
type: UnificationXref
id: K7CFQ9
db: uniprot

uniprot P08572 515
type: UnificationXref
id: P08572
db: uniprot

uniprot Q16363 1230
type: UnificationXref
id: Q16363
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 66

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q7ZWH4 244
xref: PTHR12644:SF1
organism: Danio rerio

uniprot P50551 849
type: UnificationXref
id: P50551
db: uniprot

C3G
type: Protein
entity reference: C3G
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A7STP5 286
type: UnificationXref
id: A7STP5
db: uniprot

Rho GTPase-activating protein 10
type: ProteinReference
xref: PTHR12552:SF5
xref: uniprot A1A4S6 670
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r14 1519
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F1PXS7 108
organism: Canis lupus familiaris

Caveolin-1
type: ProteinReference
xref: uniprot P33724 349
xref: PTHR10844:SF18
organism: Canis lupus familiaris

uniprot F1LPI5 1192
type: UnificationXref
id: F1LPI5
db: uniprot

PTHR10574:SF282
type: RelationshipXref
id: PTHR10574:SF282
db: PANTHER Family
relationship type: By Homology

PIP2 s91 sa100 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

PTHR10574:SF285
type: RelationshipXref
id: PTHR10574:SF285
db: PANTHER Family
relationship type: By Homology

uniprot H2QV00 220
type: UnificationXref
id: H2QV00
db: uniprot

PTHR24072:SF301
type: RelationshipXref
id: PTHR24072:SF301
db: PANTHER Family
relationship type: By Homology

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F1Q118 373
xref: PTHR23113:SF168
organism: Canis lupus familiaris

uniprot F7EGF5 464
type: UnificationXref
id: F7EGF5
db: uniprot

Integrin beta
type: ProteinReference
xref: PTHR10082:SF9
xref: uniprot A0A2I3T078 761
organism: Pan troglodytes

uniprot Q6TEN1 81
type: UnificationXref
id: Q6TEN1
db: uniprot

uniprot F0ZWE6 295
type: UnificationXref
id: F0ZWE6
db: uniprot

RAP2A, member of RAS oncogene family b
type: ProteinReference
xref: PTHR24070:SF221
xref: uniprot B8JIV0 15
organism: Danio rerio

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 319

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: uniprot P85970 233
xref: PTHR12058:SF0
organism: Rattus norvegicus

PTHR10574:SF270
type: RelationshipXref
id: PTHR10574:SF270
db: PANTHER Family
relationship type: By Homology

PTHR10574:SF279
type: RelationshipXref
id: PTHR10574:SF279
db: PANTHER Family
relationship type: By Homology

Rho-related GTP-binding protein RhoA-A
type: ProteinReference
xref: uniprot Q6NUX8 1298
xref: PTHR24072:SF100
organism: Danio rerio

NRAS protein
type: ProteinReference
xref: uniprot A5D7R9 285
xref: PTHR24070:SF189
organism: Bos taurus

uniprot F7GXE0 1032
type: UnificationXref
id: F7GXE0
db: uniprot

uniprot A0A2I3SRL3 169
type: UnificationXref
id: A0A2I3SRL3
db: uniprot

PTHR24023:SF58
type: RelationshipXref
id: PTHR24023:SF58
db: PANTHER Family
relationship type: By Homology

Integrin beta
type: ProteinReference
xref: uniprot Q7QE55 810
xref: PTHR10082:SF41
organism: Anopheles gambiae

PTHR19969:SF20
type: RelationshipXref
id: PTHR19969:SF20
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HGW0 471
xref: PTHR23220:SF5
organism: Macaca mulatta

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot Q9Z1L0 954
organism: Rattus norvegicus

Vinculin
type: Protein
entity reference: Vinculin
feature: COMPLEX PARTICIPANT BINDING FEATURE s41 sa41 1374
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

GTPase NRas
type: ProteinReference
xref: uniprot P79737 322
xref: PTHR24070:SF189
organism: Danio rerio

uniprot H2R472 840
type: UnificationXref
id: H2R472
db: uniprot

uniprot F6T0B3 447
type: UnificationXref
id: F6T0B3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24023:SF509
xref: uniprot F7HA80 470
organism: Macaca mulatta

Guanine nucleotide-releasing factor 2
type: ProteinReference
xref: uniprot O77086 747
xref: PTHR23113:SF224
organism: Drosophila melanogaster

ADP-ribosylation factor 6a
type: ProteinReference
xref: uniprot Q6P2U5 368
xref: PTHR11711:SF322
organism: Danio rerio

uniprot A0A1D5RJ31 201
type: UnificationXref
id: A0A1D5RJ31
db: uniprot

ncbitaxon 5759 13
type: UnificationXref
id: 5759
db: ncbitaxon

ILK
type: ProteinReference
xref: P00935
standard name: Integrin linked kinase
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.ILK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Integrin-linked protein kinase
member entity reference: Integrin linked kinase
member entity reference: Integrin linked kinase, isoform A
member entity reference: Uncharacterized protein
member entity reference: Integrin-linked kinase

PTHR10574:SF298
type: RelationshipXref
id: PTHR10574:SF298
db: PANTHER Family
relationship type: By Homology

PTHR10574:SF291
type: RelationshipXref
id: PTHR10574:SF291
db: PANTHER Family
relationship type: By Homology

Ras protein let-60
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot P22981 320
organism: Caenorhabditis elegans

uniprot A0A2R8Q8S1 284
type: UnificationXref
id: A0A2R8Q8S1
db: uniprot

Collagen alpha-2(I) chain
type: ProteinReference
xref: PTHR24023:SF568
xref: uniprot F1PHY1 441
organism: Canis lupus familiaris

uniprot P79737 322
type: UnificationXref
id: P79737
db: uniprot

uniprot C3Z3B1 591
type: UnificationXref
id: C3Z3B1
db: uniprot

Arp2 3 s89 sa98 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Arp2/3
stoichiometric coefficient: 1.0

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot Q6P378 1155
organism: Xenopus tropicalis

uniprot P06241 1098
type: UnificationXref
id: P06241
db: uniprot

Beta-parvin
type: ProteinReference
xref: PTHR12114:SF7
xref: uniprot Q9HBI1 1171
organism: Homo sapiens

uniprot Q60675 1235
type: UnificationXref
id: Q60675
db: uniprot

NRAS proto-oncogene, GTPase
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot F1PHV7 296
organism: Canis lupus familiaris

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q2TY19 1330
xref: PTHR24055:SF222
organism: Gallus gallus

uniprot Q9NVD7 1172
type: UnificationXref
id: Q9NVD7
db: uniprot

eco ECO:0000316 686
type: UnificationXref
id: ECO:0000316
db: eco

Collagen type XI alpha 2 chain
type: ProteinReference
xref: PTHR24023:SF509
xref: uniprot A0A2I3RUR0 404
organism: Pan troglodytes

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7DUD6 899
xref: PTHR10048:SF107
organism: Ornithorhynchus anatinus

Engulfment and cell motility 1
type: ProteinReference
xref: uniprot A0A2I3S6R6 332
xref: PTHR12771:SF23
organism: Pan troglodytes

ncbitaxon 3055 586
type: UnificationXref
id: 3055
db: ncbitaxon

Fyn
type: Protein
entity reference: Fyn
feature: ACTIVE 89
feature: COMPLEX PARTICIPANT BINDING FEATURE s377 a445 1390
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q0VD16 146
type: UnificationXref
id: Q0VD16
db: uniprot

uniprot A0A1L1RMP9 584
type: UnificationXref
id: A0A1L1RMP9
db: uniprot

uniprot K7C8W0 494
type: UnificationXref
id: K7C8W0
db: uniprot

RAP2A isoform 1
type: ProteinReference
xref: PTHR24070:SF221
xref: uniprot H2Q7Q7 51
organism: Pan troglodytes

uniprot Q9VIM5 251
type: UnificationXref
id: Q9VIM5
db: uniprot

Laminin
type: Protein
entity reference: Laminin
feature: COMPLEX PARTICIPANT BINDING FEATURE s56 sa62 1400
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

LIM and senescent cell antigen-like-containing domain protein
type: ProteinReference
xref: uniprot E2RKQ1 389
xref: PTHR24210:SF11
organism: Canis lupus familiaris

A-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot E2RL20 631
organism: Canis lupus familiaris

Novel Rho protein
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot Q28HZ4 1290
organism: Xenopus tropicalis

uniprot F6YDU5 453
type: UnificationXref
id: F6YDU5
db: uniprot

Protein-tyrosine kinase 2-beta
type: ProteinReference
xref: PTHR24418:SF94
xref: uniprot Q9QVP9 834
organism: Mus musculus

Rho-related protein racC
type: ProteinReference
xref: uniprot P34149 695
xref: PTHR24072:SF310
organism: Dictyostelium discoideum

Y925 FAK s66 sa72 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y925
feature location: Y925 FAK s66 sa72 rs2 Y925
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.58380694263043
comment: MODIFICATION_RESIDUE_NAME=Y925

Rho-related protein racB
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P34148 694
organism: Dictyostelium discoideum

Rho-related protein rac1B
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P34145 693
organism: Dictyostelium discoideum

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p130CAS-RIGHT__p130CAS-_r36
controller: Complex (Paxillin/PTP-PEST)

uniprot F7GN93 120
type: UnificationXref
id: F7GN93
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF221
xref: uniprot F7DH11 47
organism: Monodelphis domestica

Arf1
type: Protein
entity reference: Arf1
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Filamin
type: Protein
entity reference: Filamin
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa37 1430
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Jnk
type: ProteinReference
xref: P00951
standard name: C-Jun N-terminal kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: C-Jun N-terminal kinase Synonym: C-Jun N-terminal kinase,Jnk Accession: P00951
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Jnk
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 10
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Stress-activated protein kinase JNK
member entity reference: Stress-activated protein kinase jnk-1
member entity reference: MAP kinase kinase 4, isoform A

PTHR10844:SF18
type: RelationshipXref
id: PTHR10844:SF18
db: PANTHER Family
relationship type: By Homology

uniprot P24063 1062
type: UnificationXref
id: P24063
db: uniprot

uniprot P34152 828
type: UnificationXref
id: P34152
db: uniprot

Laminin
type: Protein
entity reference: Laminin
feature: COMPLEX PARTICIPANT BINDING FEATURE s76 sa82 1472
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot E2RC09 1093
type: UnificationXref
id: E2RC09
db: uniprot

uniprot O44386 1047
type: UnificationXref
id: O44386
db: uniprot

uniprot F1NAB9 437
type: UnificationXref
id: F1NAB9
db: uniprot

Filamin-A
type: ProteinReference
xref: PTHR38537:SF5
xref: uniprot P21333 275
organism: Homo sapiens

uniprot P22126 318
type: UnificationXref
id: P22126
db: uniprot

uniprot F6TXC2 111
type: UnificationXref
id: F6TXC2
db: uniprot

CRK like proto-oncogene, adaptor protein
type: ProteinReference
xref: uniprot H2R472 840
xref: PTHR19969:SF20
organism: Pan troglodytes

ITGA4 isoform 3
type: ProteinReference
xref: PTHR23220:SF78
xref: uniprot H2QJ29 1041
organism: Pan troglodytes

GTP-binding protein RHO1
type: ProteinReference
xref: uniprot O42825 1272
xref: PTHR24072:SF168
organism: Candida albicans

Uncharacterized protein
type: ProteinReference
xref: PTHR12552:SF5
xref: uniprot F6VTW2 675
organism: Macaca mulatta

MODULATION
type: RelationshipTypeVocabulary

NTN4 protein
type: ProteinReference
xref: uniprot A7MB18 1186
xref: PTHR10574:SF282
organism: Bos taurus

PTHR24418:SF194
type: RelationshipXref
id: PTHR24418:SF194
db: PANTHER Family
relationship type: By Homology

00696
type: UnificationXref
id: MOD:00696
db: mod

uniprot P62745 1282
type: UnificationXref
id: P62745
db: uniprot

uniprot F1Q118 373
type: UnificationXref
id: F1Q118
db: uniprot

PTHR24070:SF200
type: RelationshipXref
id: PTHR24070:SF200
db: PANTHER Family
relationship type: By Homology

uniprot P42338 931
type: UnificationXref
id: P42338
db: uniprot

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot Q9JM76 249
xref: PTHR12391:SF1
organism: Mus musculus

uniprot A0A2I3T9A8 387
type: UnificationXref
id: A0A2I3T9A8
db: uniprot

C3G
type: Protein
entity reference: C3G
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa19 1478
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P02468 1216
type: UnificationXref
id: P02468
db: uniprot

PTHR24070:SF206
type: RelationshipXref
id: PTHR24070:SF206
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot G7MGQ5 907
organism: Macaca mulatta

ADP-ribosylation factor-like protein 1
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot Q2YDM1 613
organism: Bos taurus

uniprot P60711 1140
type: UnificationXref
id: P60711
db: uniprot

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: uniprot Q99759 162
organism: Homo sapiens

uniprot Q562R1 1150
type: UnificationXref
id: Q562R1
db: uniprot

Evidence 635
type: Evidence
evidence code: IPI
comment: SPACC P04049

uniprot A0A1D5P0F4 400
type: UnificationXref
id: A0A1D5P0F4
db: uniprot

ncbitaxon 284811 1307
type: UnificationXref
id: 284811
db: ncbitaxon

STATE_TRANSITION_LEFT__FAK-RIGHT__FAK-_r10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 1545
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 1546
left: FAK
interaction type: STATE_TRANSITION
right: FAK

Integrin-linked protein kinase
type: ProteinReference
xref: uniprot Q99J82 860
organism: Rattus norvegicus

uniprot P02751 976
type: UnificationXref
id: P02751
db: uniprot

uniprot P08514 1051
type: UnificationXref
id: P08514
db: uniprot

uniprot F7EGH9 279
type: UnificationXref
id: F7EGH9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24023:SF58
xref: uniprot F7B3R3 460
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XD59 451
xref: PTHR24020:SF29
organism: Macaca mulatta

Evidence 643
type: Evidence
evidence code: IPI
comment: SPACC Q99N57

Laminin subunit alpha-1
type: ProteinReference
xref: PTHR10574:SF409
xref: uniprot P19137 1222
organism: Mus musculus

Evidence 640
type: Evidence
evidence code: IPI
comment: SPACC P11345

uniprot E2RHL4 356
type: UnificationXref
id: E2RHL4
db: uniprot

PTHR38537:SF5
type: RelationshipXref
id: PTHR38537:SF5
db: PANTHER Family
relationship type: By Homology

uniprot Q5TQ35 1234
type: UnificationXref
id: Q5TQ35
db: uniprot

PTHR38537:SF7
type: RelationshipXref
id: PTHR38537:SF7
db: PANTHER Family
relationship type: By Homology

Evidence 627
type: Evidence
evidence code: ISS
comment: SPACC Q99N57

Evidence 626
type: Evidence
evidence code: ISS
comment: SPACC P11345

uniprot K7CZM1 380
type: UnificationXref
id: K7CZM1
db: uniprot

uniprot P63085 142
type: UnificationXref
id: P63085
db: uniprot

Evidence 625
type: Evidence
evidence code: ISS
comment: SPACC P05625

Evidence 624
type: Evidence
evidence code: ISS
comment: SPACC P04049

Integrin subunit alpha 9
type: ProteinReference
xref: PTHR23220:SF69
xref: uniprot F1MMH2 1016
organism: Bos taurus

uniprot P39061 539
type: UnificationXref
id: P39061
db: uniprot

MAP3K2 isoform 1
type: ProteinReference
xref: uniprot H2QIN7 125
organism: Pan troglodytes

Shc s287 a421 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.02298445744145208
comment: MODIFICATION_RESIDUE_NAME=

PTHR24070:SF221
type: RelationshipXref
id: PTHR24070:SF221
db: PANTHER Family
relationship type: By Homology

Rho family GTPase
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot C4M8K6 688
organism: Entamoeba histolytica

ITGBL1 isoform 2
type: ProteinReference
xref: uniprot H2R464 779
xref: PTHR10082:SF3
organism: Pan troglodytes

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QS62 1339
xref: PTHR24055:SF172
organism: Pan troglodytes

uniprot P09055 789
type: UnificationXref
id: P09055
db: uniprot

Integrin alpha ina-1
type: ProteinReference
xref: uniprot Q03600 1071
xref: PTHR23220:SF122
organism: Caenorhabditis elegans

Paxillin
type: Protein
entity reference: Paxillin
feature: Paxillin s53 a132 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a
type: ProteinReference
xref: PTHR10048:SF28
xref: uniprot D3ZTF6 875
organism: Rattus norvegicus

uniprot H2Q5T9 1268
type: UnificationXref
id: H2Q5T9
db: uniprot

uniprot Q08DI5 72
type: UnificationXref
id: Q08DI5
db: uniprot

uniprot Q9Y2U5 166
type: UnificationXref
id: Q9Y2U5
db: uniprot

PTHR24418:SF162
type: RelationshipXref
id: PTHR24418:SF162
db: PANTHER Family
relationship type: By Homology

uniprot Q9Y6N6 1247
type: UnificationXref
id: Q9Y6N6
db: uniprot

uniprot P62835 70
type: UnificationXref
id: P62835
db: uniprot

uniprot H2Q383 909
type: UnificationXref
id: H2Q383
db: uniprot

uniprot F7DXH6 985
type: UnificationXref
id: F7DXH6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GRAF-RIGHT__GRAF-_r112
controller: FAK

uniprot F7AC47 42
type: UnificationXref
id: F7AC47
db: uniprot

Fibronectin
type: ProteinReference
xref: uniprot P02751 976
xref: PTHR19143:SF267
organism: Homo sapiens

Protein tyrosine kinase 2ab
type: ProteinReference
xref: uniprot A0A2R8RR02 817
xref: PTHR24418:SF78
organism: Danio rerio

Growth factor receptor-bound protein 2a
type: ProteinReference
xref: PTHR46037:SF4
xref: uniprot Q5RKN6 191
organism: Danio rerio

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot P46734 665
organism: Homo sapiens

uniprot P15056 198
type: UnificationXref
id: P15056
db: uniprot

Laminin subunit gamma 3
type: ProteinReference
xref: uniprot A0A0G2K023 1175
xref: PTHR10574:SF240
organism: Rattus norvegicus

uniprot J9NYD7 1046
type: UnificationXref
id: J9NYD7
db: uniprot

Csk
type: ProteinReference
xref: P00913
standard name: C-terminal Src kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Csk
comment: ENTITY_REFERENCE_NOTES=Long Name: C-terminal Src kinase Synonym: C-terminal Src kinase,Csk Accession: P00913
member entity reference: Tyrosine-protein kinase CSK
member entity reference: Tyrosine-protein kinase

Integrin subunit alpha 1
type: ProteinReference
xref: uniprot F1MMN6 1017
xref: PTHR23220:SF22
organism: Bos taurus

uniprot H2QDE3 1040
type: UnificationXref
id: H2QDE3
db: uniprot

PTHR10155:SF3
type: RelationshipXref
id: PTHR10155:SF3
db: PANTHER Family
relationship type: By Homology

DnaJ homolog subfamily C member 27 isoform 1
type: ProteinReference
xref: uniprot F7AC47 42
organism: Macaca mulatta

uniprot F7CLM4 1106
type: UnificationXref
id: F7CLM4
db: uniprot

GTP-binding protein rhoA
type: ProteinReference
xref: uniprot Q9C3Y4 1304
xref: PTHR24072:SF168
organism: Emericella nidulans

uniprot F1MRP6 435
type: UnificationXref
id: F1MRP6
db: uniprot

Laminin subunit alpha 2
type: ProteinReference
xref: uniprot F1M614 1194
xref: PTHR10574:SF291
organism: Rattus norvegicus

uniprot H2QIN7 125
type: UnificationXref
id: H2QIN7
db: uniprot

uniprot Q9QXQ0 743
type: UnificationXref
id: Q9QXQ0
db: uniprot

HETERODIMER ASSOCIATION LEFT Complex alpha actinin Actin - Filamin- Paxillin- Complex Integrin beta Integrin alpha Integrin beta Integrin alpha Collagen Laminin Fibronectin - Talin- Complex Vinculin Actin -RIGHT Complex Integrin alpha Paxillin Integrin beta Talin Vinculin Actin Integrin alpha alpha actinin Actin Integrin beta Filamin Collagen Laminin Fibronectin - r41
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 1548
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 1553
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 1549
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 1547
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 1552
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 1551
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 1550
left: Talin
left: Filamin
left: Paxillin
left: Complex (Vinculin/Actin)
left: Complex (Integrin beta/Integrin _alpha/ Integrin beta/Integrin _alpha/ Collagen/Laminin/ Fibronectin)
left: Complex (alpha actinin/Actin)
display name: HETERODIMER_ASSOCIATION_LEFT__Complex__alpha_actinin_Actin_-_Filamin-_Paxillin-_Complex__Integrin_beta_Integrin__alpha__Integrin_beta_Integrin__alpha__Collagen_Laminin__Fibronectin_-_Talin-_Complex__Vinculin_Actin_-RIGHT__Complex__Integrin__alpha_Paxillin__Integrin_beta_Talin__Vinculin_Actin__Integrin__alpha_alpha_actinin__Actin_Integrin_beta__Filamin_Collagen__Laminin_Fibronectin_-_r41
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Integrin _alpha/Paxillin/ Integrin beta/Talin/ Vinculin/Actin/ Integrin _alpha/alpha actinin/ Actin/Integrin beta/ Filamin/Collagen/ Laminin/Fibronectin)

PTHR10155:SF2
type: RelationshipXref
id: PTHR10155:SF2
db: PANTHER Family
relationship type: By Homology

PTHR10155:SF1
type: RelationshipXref
id: PTHR10155:SF1
db: PANTHER Family
relationship type: By Homology

Alpha-actinin-4
type: ProteinReference
xref: uniprot P57780 734
xref: PTHR11915:SF425
organism: Mus musculus

uniprot P32577 261
type: UnificationXref
id: P32577
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot F7HPR8 1313
organism: Macaca mulatta

Collagen alpha-1(XII) chain
type: ProteinReference
xref: uniprot Q99715 570
xref: PTHR24020:SF17
organism: Homo sapiens

uniprot F7HA80 470
type: UnificationXref
id: F7HA80
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot Q6RUV5 703
xref: PTHR24072:SF105
organism: Rattus norvegicus

uniprot O75578 1048
type: UnificationXref
id: O75578
db: uniprot

uniprot Q6NT85 619
type: UnificationXref
id: Q6NT85
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot A0A1D5QE27 864
xref: PTHR10048:SF7
organism: Macaca mulatta

PTHR23220:SF4
type: RelationshipXref
id: PTHR23220:SF4
db: PANTHER Family
relationship type: By Homology

uniprot P26007 1064
type: UnificationXref
id: P26007
db: uniprot

PTHR23220:SF5
type: RelationshipXref
id: PTHR23220:SF5
db: PANTHER Family
relationship type: By Homology

PTHR23220:SF3
type: RelationshipXref
id: PTHR23220:SF3
db: PANTHER Family
relationship type: By Homology

uniprot P19137 1222
type: UnificationXref
id: P19137
db: uniprot

PTHR23220:SF9
type: RelationshipXref
id: PTHR23220:SF9
db: PANTHER Family
relationship type: By Homology

uniprot F1NM67 769
type: UnificationXref
id: F1NM67
db: uniprot

ARHGAP26 isoform 1
type: ProteinReference
xref: PTHR12552:SF4
xref: uniprot H2QRP5 676
organism: Pan troglodytes

PTHR10574:SF240
type: RelationshipXref
id: PTHR10574:SF240
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r14 1522
type: Stoichiometry
physical entity: Complex (Grb2/SOS/ FAK)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 1520
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 1521
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

Engulfment and cell motility protein 2
type: ProteinReference
xref: PTHR12771:SF8
xref: uniprot Q96JJ3 347
organism: Homo sapiens

uniprot F1P750 106
type: UnificationXref
id: F1P750
db: uniprot

uniprot Q5F352 329
type: UnificationXref
id: Q5F352
db: uniprot

COL3A1 isoform 1
type: ProteinReference
xref: PTHR24023:SF604
xref: uniprot H2QJ46 477
organism: Pan troglodytes

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot A0A0G2K5T3 863
xref: PTHR10048:SF107
organism: Rattus norvegicus

PTHR12771:SF23
type: RelationshipXref
id: PTHR12771:SF23
db: PANTHER Family
relationship type: By Homology

uniprot Q9V9J3 994
type: UnificationXref
id: Q9V9J3
db: uniprot

PTHR10574:SF233
type: RelationshipXref
id: PTHR10574:SF233
db: PANTHER Family
relationship type: By Homology

Crk
type: Protein
entity reference: Crk
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa24 1414
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q05707 549
type: UnificationXref
id: Q05707
db: uniprot

uniprot Q4KLF8 238
type: UnificationXref
id: Q4KLF8
db: uniprot

Focal adhesion kinase 1
type: ProteinReference
xref: uniprot O35346 827
xref: PTHR24418:SF78
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F7EI48 119
organism: Monodelphis domestica

MAP kinase kinase 4, isoform A
type: ProteinReference
xref: uniprot O61444 661
xref: PTHR48013:SF15
organism: Drosophila melanogaster

uniprot Q61083 153
type: UnificationXref
id: Q61083
db: uniprot

ncbitaxon 9913 8
type: UnificationXref
id: 9913
db: ncbitaxon

Caveolin s47 sa58 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Caveolin
stoichiometric coefficient: 1.0

PTHR19981:SF7
type: RelationshipXref
id: PTHR19981:SF7
db: PANTHER Family
relationship type: By Homology

Integrin alpha
type: Protein
entity reference: Integrin alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 1360
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P05480 990
type: UnificationXref
id: P05480
db: uniprot

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 1252

PTHR19981:SF1
type: RelationshipXref
id: PTHR19981:SF1
db: PANTHER Family
relationship type: By Homology

Ras-like protein rasB
type: ProteinReference
xref: uniprot P32252 321
xref: PTHR24070:SF206
organism: Dictyostelium discoideum

uniprot Q02788 545
type: UnificationXref
id: Q02788
db: uniprot

uniprot Q61092 1238
type: UnificationXref
id: Q61092
db: uniprot

AGAP000018-PA
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot Q7QEJ7 947
organism: Anopheles gambiae

uniprot P34148 694
type: UnificationXref
id: P34148
db: uniprot

Rho family GTPase 2
type: ProteinReference
xref: uniprot F1MUP6 1260
xref: PTHR24072:SF21
organism: Bos taurus

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: PTHR12644:SF1
xref: uniprot Q3SYX9 236
organism: Bos taurus

Integrin alpha-5
type: ProteinReference
xref: uniprot P11688 1054
xref: PTHR23220:SF3
organism: Mus musculus

uniprot F6UCA3 390
type: UnificationXref
id: F6UCA3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23220:SF23
xref: uniprot F6W6R0 1023
organism: Macaca mulatta

uniprot F7C2C6 117
type: UnificationXref
id: F7C2C6
db: uniprot

Laminin subunit alpha 1
type: ProteinReference
xref: PTHR10574:SF409
xref: uniprot A0A2I3T8I1 1179
organism: Pan troglodytes

uniprot F6XEQ9 452
type: UnificationXref
id: F6XEQ9
db: uniprot

Tyrosine-protein kinase Src64B
type: ProteinReference
xref: PTHR24418:SF194
xref: uniprot P00528 989
organism: Drosophila melanogaster

Laminin subunit gamma 1
type: ProteinReference
xref: uniprot F1PHK9 1197
xref: PTHR10574:SF270
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot E1BMX0 290
organism: Bos taurus

uniprot Q64143 942
type: UnificationXref
id: Q64143
db: uniprot

Tyrosine-protein kinase ABL1
type: ProteinReference
xref: PTHR24418:SF162
xref: uniprot P00520 1174
organism: Mus musculus

Proto-oncogene tyrosine-protein kinase Src
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot P00523 988
organism: Gallus gallus

uniprot F6QUW1 374
type: UnificationXref
id: F6QUW1
db: uniprot

Ras-related protein R-Ras
type: ProteinReference
xref: PTHR24070:SF245
xref: uniprot D3Z8L7 289
organism: Rattus norvegicus

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 5

uniprot F1PHY1 441
type: UnificationXref
id: F1PHY1
db: uniprot

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F1PXD3 652
organism: Canis lupus familiaris

uniprot P06756 1050
type: UnificationXref
id: P06756
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9Z1B7 168
organism: Mus musculus

uniprot Q03692 546
type: UnificationXref
id: Q03692
db: uniprot

PTHR24023:SF1023
type: RelationshipXref
id: PTHR24023:SF1023
db: PANTHER Family
relationship type: By Homology

uniprot P11087 516
type: UnificationXref
id: P11087
db: uniprot

uniprot F7AFB2 391
type: UnificationXref
id: F7AFB2
db: uniprot

PTHR24023:SF1027
type: RelationshipXref
id: PTHR24023:SF1027
db: PANTHER Family
relationship type: By Homology

uniprot F1N157 1019
type: UnificationXref
id: F1N157
db: uniprot

uniprot E1B8P9 99
type: UnificationXref
id: E1B8P9
db: uniprot

PTHR12114:SF6
type: RelationshipXref
id: PTHR12114:SF6
db: PANTHER Family
relationship type: By Homology

RAP2A, member of RAS oncogene family
type: ProteinReference
xref: PTHR24070:SF221
xref: uniprot J9P6K0 54
organism: Canis lupus familiaris

PTHR12114:SF7
type: RelationshipXref
id: PTHR12114:SF7
db: PANTHER Family
relationship type: By Homology

uniprot F7GRP2 259
type: UnificationXref
id: F7GRP2
db: uniprot

COL11A1 isoform 2
type: ProteinReference
xref: PTHR24023:SF42
xref: uniprot A0A2I3TI23 408
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR24023:SF1027
xref: uniprot F7GWI9 468
organism: Macaca mulatta

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 46

MEK
type: ProteinReference
xref: P00925
standard name: Mitogen-activated protein kinase kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen activated protein kinase kinase Synonym: MAP kinase kinase,MAP/ERK kinase,MAPKK Accession: P00925
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.MEK
member entity reference: Dual specificity mitogen-activated protein kinase kinase 2
member entity reference: Dual specificity mitogen-activated protein kinase kinase 4
member entity reference: Uncharacterized protein
member entity reference: Dual specificity mitogen-activated protein kinase kinase 1
member entity reference: Mitogen-activated protein kinase kinase 4A
member entity reference: Mitogen-activated protein kinase kinase 2
member entity reference: Mitogen-activated protein kinase kinase 3
member entity reference: MAP2K2 isoform 1
member entity reference: Map2k3 protein
member entity reference: Dual-specificity mitogen-activated protein kinase kinase 2
member entity reference: Mitogen-activated protein kinase kinase 4
member entity reference: Mitogen-activated protein kinase kinase 1
member entity reference: MAP2K1 protein
member entity reference: Dual specificity mitogen-activated protein kinase kinase 3
member entity reference: MAP2K4 protein
member entity reference: MAP kinase kinase 4, isoform A
member entity reference: MAP2K4 isoform 3

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5P4L2 1176
xref: PTHR10574:SF36
organism: Gallus gallus

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F7FWN9 986
xref: PTHR24418:SF53
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR12114:SF7
xref: uniprot E1C891 1163
organism: Gallus gallus

uniprot F7GLY8 657
type: UnificationXref
id: F7GLY8
db: uniprot

PARTICIPANT STOICHIOMETRY r111 1580
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

FAK s181 a240 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.851793120491741

uniprot B7PHY7 962
type: UnificationXref
id: B7PHY7
db: uniprot

STATE_TRANSITION_LEFT__Arf6-RIGHT__Arf6-_r118
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r118 1557
participant stoichiometry: PARTICIPANT STOICHIOMETRY r118 1558
left: Arf6
interaction type: STATE_TRANSITION
right: Arf6

uniprot H2RD92 489
type: UnificationXref
id: H2RD92
db: uniprot

PTHR24072:SF281
type: RelationshipXref
id: PTHR24072:SF281
db: PANTHER Family
relationship type: By Homology

PTHR24070:SF245
type: RelationshipXref
id: PTHR24070:SF245
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r33 1583
type: Stoichiometry
physical entity: Complex (Csk/Paxillin)
stoichiometric coefficient: 1.0

PTHR24023:SF1005
type: RelationshipXref
id: PTHR24023:SF1005
db: PANTHER Family
relationship type: By Homology

uniprot H2QCA7 658
type: UnificationXref
id: H2QCA7
db: uniprot

RAP2B, member of RAS oncogene family
type: ProteinReference
xref: PTHR24070:SF194
xref: uniprot Q7SY59 82
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r33 1581
type: Stoichiometry
physical entity: Csk
stoichiometric coefficient: 1.0

uniprot F1MAI3 370
type: UnificationXref
id: F1MAI3
db: uniprot

PARTICIPANT STOICHIOMETRY r33 1582
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

PTHR24023:SF1009
type: RelationshipXref
id: PTHR24023:SF1009
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r111 1579
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

RAP2A, member of RAS oncogene family
type: ProteinReference
xref: PTHR24070:SF221
xref: uniprot F6YT39 38
organism: Xenopus tropicalis

Netrin-4
type: ProteinReference
xref: uniprot Q9HB63 1244
xref: PTHR10574:SF282
organism: Homo sapiens

uniprot Q7QE55 810
type: UnificationXref
id: Q7QE55
db: uniprot

uniprot F6QQX8 717
type: UnificationXref
id: F6QQX8
db: uniprot

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot O08648 131
organism: Mus musculus

Ras-like protein 3, putative
type: ProteinReference
xref: PTHR24070:SF263
xref: uniprot B1N4V4 12
organism: Entamoeba histolytica

PTHR24023:SF387
type: RelationshipXref
id: PTHR24023:SF387
db: PANTHER Family
relationship type: By Homology

PTHR24072:SF290
type: RelationshipXref
id: PTHR24072:SF290
db: PANTHER Family
relationship type: By Homology

ADP-ribosylation factor 2b
type: ProteinReference
xref: PTHR11711:SF119
xref: uniprot F1QV75 597
organism: Danio rerio

Alpha-actinin-3
type: ProteinReference
xref: PTHR11915:SF432
xref: uniprot O88990 728
organism: Mus musculus

PTP PEST s26 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PTP-PEST
stoichiometric coefficient: 1.0

uniprot A0A0G2K470 997
type: UnificationXref
id: A0A0G2K470
db: uniprot

uniprot P26039 1110
type: UnificationXref
id: P26039
db: uniprot

Integrin linked kinase, isoform A
type: ProteinReference
xref: uniprot Q9V400 861
organism: Drosophila melanogaster

Vinculin
type: Protein
entity reference: Vinculin
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Filamin
type: Protein
entity reference: Filamin
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

FAK s148 a172 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.647709131634312
comment: MODIFICATION_RESIDUE_NAME=

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot Q92569 950
organism: Homo sapiens

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 627
evidence: Evidence 625
evidence: Evidence 626
evidence: Evidence 624
xref: PTHR44329:SF22
xref: uniprot A0A2I3THL4 628
organism: Pan troglodytes

PTHR24023:SF372
type: RelationshipXref
id: PTHR24023:SF372
db: PANTHER Family
relationship type: By Homology

GRAF
type: Protein
entity reference: GRAF
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7EI48 119
type: UnificationXref
id: F7EI48
db: uniprot

Paxillin
type: ProteinReference
xref: P00950
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Paxillin Synonym: Synonym not specified Accession: P00950
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Paxillin
member entity reference: Paxillin
member entity reference: Paxillin-B
member entity reference: PXN isoform 9
member entity reference: Paxillin, isoform F

PTHR24070:SF263
type: RelationshipXref
id: PTHR24070:SF263
db: PANTHER Family
relationship type: By Homology

uniprot A0A3Q1M8K4 1003
type: UnificationXref
id: A0A3Q1M8K4
db: uniprot

uniprot F1PVR1 444
type: UnificationXref
id: F1PVR1
db: uniprot

uniprot P53349 140
type: UnificationXref
id: P53349
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7GAP5 904
organism: Ornithorhynchus anatinus

Integrin alpha s27 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Integrin alpha
stoichiometric coefficient: 2.0

Uncharacterized protein
type: ProteinReference
xref: PTHR46180:SF1
xref: uniprot F1N789 955
organism: Bos taurus

FAK s148 a172 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.851793120491741

uniprot F6V7P3 450
type: UnificationXref
id: F6V7P3
db: uniprot

Integrin subunit alpha 9
type: ProteinReference
xref: PTHR23220:SF69
xref: uniprot J9NYD7 1046
organism: Canis lupus familiaris

Integrin alpha-7
type: ProteinReference
xref: uniprot Q13683 1073
xref: PTHR23220:SF90
organism: Homo sapiens

Dock180 s80 sa92 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Dock180
stoichiometric coefficient: 1.0

Collagen type V alpha 3 chain
type: ProteinReference
xref: uniprot Q9JLI2 573
xref: PTHR24023:SF1023
organism: Mus musculus

uniprot H2QNL9 53
type: UnificationXref
id: H2QNL9
db: uniprot

FAK s181 a240 rs4
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.647709131634312
comment: MODIFICATION_RESIDUE_NAME=

Engulfment and cell motility protein 1
type: ProteinReference
xref: PTHR12771:SF23
xref: uniprot Q92556 346
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot O00329 913
organism: Homo sapiens

ncbitaxon 7165 33
type: UnificationXref
id: 7165
db: ncbitaxon

Engulfment and cell motility protein 1 isoform 1
type: ProteinReference
xref: PTHR12771:SF23
xref: uniprot F7DM33 339
organism: Macaca mulatta

uniprot P07589 978
type: UnificationXref
id: P07589
db: uniprot

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: uniprot Q9VIM5 251
xref: PTHR12058:SF0
organism: Drosophila melanogaster

LAMA2 isoform 1
type: ProteinReference
xref: PTHR10574:SF291
xref: uniprot K7D0T5 1214
organism: Pan troglodytes

HETERODIMER ASSOCIATION LEFT Complex Integrin beta Integrin alpha - Complex Fibronectin Laminin Collagen -RIGHT Complex Integrin beta Integrin alpha Integrin beta Integrin alpha Collagen Laminin Fibronectin - r46
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 1524
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 1523
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 1525
left: Complex (Integrin beta/Integrin _alpha)
left: Complex (Fibronectin/Laminin/ Collagen)
display name: HETERODIMER_ASSOCIATION_LEFT__Complex__Integrin_beta_Integrin__alpha_-_Complex__Fibronectin_Laminin__Collagen_-RIGHT__Complex__Integrin_beta_Integrin__alpha__Integrin_beta_Integrin__alpha__Collagen_Laminin__Fibronectin_-_r46
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Integrin beta/Integrin _alpha/ Integrin beta/Integrin _alpha/ Collagen/Laminin/ Fibronectin)

uniprot E2RT85 428
type: UnificationXref
id: E2RT85
db: uniprot

HETERODIMER ASSOCIATION LEFT Complex Integrin beta Integrin alpha - Complex Fibronectin Laminin Collagen -RIGHT Complex Integrin beta Integrin alpha Integrin beta Integrin alpha Collagen Laminin Fibronectin - r45
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 1534
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 1535
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 1533
left: Complex (Integrin beta/Integrin _alpha)
left: Complex (Fibronectin/Laminin/ Collagen)
display name: HETERODIMER_ASSOCIATION_LEFT__Complex__Integrin_beta_Integrin__alpha_-_Complex__Fibronectin_Laminin__Collagen_-RIGHT__Complex__Integrin_beta_Integrin__alpha__Integrin_beta_Integrin__alpha__Collagen_Laminin__Fibronectin_-_r45
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Integrin beta/Integrin _alpha/ Integrin beta/Integrin _alpha/ Collagen/Laminin/ Fibronectin)

uniprot A0A2I3TWJ5 409
type: UnificationXref
id: A0A2I3TWJ5
db: uniprot

Alpha-parvin
type: ProteinReference
xref: uniprot Q9HB97 1170
xref: PTHR12114:SF6
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7AKA6 116
organism: Monodelphis domestica

uniprot A0A2I3TGE1 1002
type: UnificationXref
id: A0A2I3TGE1
db: uniprot

Mitogen-activated protein kinase kinase kinase 3 isoform 1
type: ProteinReference
xref: uniprot A0A1D5QJ66 92
organism: Macaca mulatta

uniprot E2RSH8 983
type: UnificationXref
id: E2RSH8
db: uniprot

GRB2-related adapter protein
type: ProteinReference
xref: PTHR46037:SF2
xref: uniprot F7GJG7 190
organism: Macaca mulatta

uniprot Q5A1D3 149
type: UnificationXref
id: Q5A1D3
db: uniprot

uniprot P57780 734
type: UnificationXref
id: P57780
db: uniprot

Collagen type XI alpha 1 chain
type: ProteinReference
xref: uniprot J9NYK4 490
xref: PTHR24023:SF42
organism: Canis lupus familiaris

uniprot Q5F3W3 151
type: UnificationXref
id: Q5F3W3
db: uniprot

uniprot H2QML4 1269
type: UnificationXref
id: H2QML4
db: uniprot

Collagen alpha-1(XI) chain
type: ProteinReference
xref: PTHR24023:SF42
xref: uniprot Q61245 560
organism: Mus musculus

Integrin alpha-2
type: ProteinReference
xref: PTHR23220:SF23
xref: uniprot Q62469 1079
organism: Mus musculus

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot A0A2I3TRY9 869
xref: PTHR10048:SF7
organism: Pan troglodytes

uniprot P62739 1142
type: UnificationXref
id: P62739
db: uniprot

uniprot Q5RKN6 191
type: UnificationXref
id: Q5RKN6
db: uniprot

PARTICIPANT STOICHIOMETRY r107 1604
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

uniprot A8XBU1 820
type: UnificationXref
id: A8XBU1
db: uniprot

PARTICIPANT STOICHIOMETRY r107 1605
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

uniprot F6T4B4 1022
type: UnificationXref
id: F6T4B4
db: uniprot

Integrin alpha-3
type: ProteinReference
xref: PTHR23220:SF89
xref: uniprot Q62470 1080
organism: Mus musculus

Predicted protein
type: ProteinReference
xref: uniprot A7RU31 1114
xref: PTHR11937:SF387
organism: Nematostella vectensis

ILK s60 sa87 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ILK
stoichiometric coefficient: 1.0

uniprot P14056 641
type: UnificationXref
id: P14056
db: uniprot

Netrin 4
type: ProteinReference
xref: uniprot K7C5Y1 1212
xref: PTHR10574:SF282
organism: Pan troglodytes

Rho family GTPase 1
type: ProteinReference
xref: uniprot Q5FVG9 1293
xref: PTHR24072:SF23
organism: Rattus norvegicus

PTHR24023:SF42
type: RelationshipXref
id: PTHR24023:SF42
db: PANTHER Family
relationship type: By Homology

uniprot P02465 506
type: UnificationXref
id: P02465
db: uniprot

Vinculin
type: Protein
entity reference: Vinculin
feature: ACTIVE 89
feature: COMPLEX PARTICIPANT BINDING FEATURE s90 sa99 1368
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Predicted protein
type: ProteinReference
xref: PTHR11937:SF473
xref: uniprot A7SEB1 1117
organism: Nematostella vectensis

uniprot G7MGQ5 907
type: UnificationXref
id: G7MGQ5
db: uniprot

uniprot A0A1D5Q4B3 174
type: UnificationXref
id: A0A1D5Q4B3
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 20

uniprot A0A3Q1MGL7 7
type: UnificationXref
id: A0A3Q1MGL7
db: uniprot

FAK
type: Protein
entity reference: FAK
feature: FAK s181 a240 rs4
feature: Y397 FAK s181 a240 rs1
feature: ACTIVE 89
feature: FAK s181 a240 rs3
feature: Y925 FAK s181 a240 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r120 1543
type: Stoichiometry
physical entity: VASP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r120 1542
type: Stoichiometry
physical entity: Complex (PIP2/Vinculin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r120 1544
type: Stoichiometry
physical entity: Complex (Vinculin/PIP2/ VASP)
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

ncbitaxon 665079 1252
type: UnificationXref
id: 665079
db: ncbitaxon

uniprot Q6NVL3 1299
type: UnificationXref
id: Q6NVL3
db: uniprot

INHIBITION
type: RelationshipTypeVocabulary

uniprot Q14031 553
type: UnificationXref
id: Q14031
db: uniprot

Predicted protein
type: ProteinReference
xref: uniprot A7SEA7 1116
xref: PTHR11937:SF387
organism: Nematostella vectensis

Ras-related protein Rap-1b
type: ProteinReference
xref: PTHR24070:SF393
xref: uniprot Q99JI6 86
organism: Mus musculus

Predicted protein
type: ProteinReference
xref: uniprot A7S615 355
xref: PTHR11711:SF322
organism: Nematostella vectensis

uniprot Q6DRM4 1167
type: UnificationXref
id: Q6DRM4
db: uniprot

ADP ribosylation factor 1
type: ProteinReference
xref: uniprot F1NN08 596
xref: PTHR11711:SF357
organism: Gallus gallus

uniprot A0A2I3SC11 758
type: UnificationXref
id: A0A2I3SC11
db: uniprot

Collagen alpha-1(I) chain
type: ProteinReference
xref: PTHR24023:SF569
xref: uniprot P11087 516
organism: Mus musculus

Integrin beta
type: ProteinReference
xref: PTHR10082:SF25
xref: uniprot F1PPG5 770
organism: Canis lupus familiaris

LD28067p
type: ProteinReference
xref: uniprot Q7K3H0 944
xref: PTHR10048:SF64
organism: Drosophila melanogaster

uniprot F1MA59 432
type: UnificationXref
id: F1MA59
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot O15511 228
xref: PTHR12644:SF1
organism: Homo sapiens

Laminin s76 sa82 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Laminin
stoichiometric coefficient: 1.0

Integrin subunit alpha 6
type: ProteinReference
xref: uniprot E2RL88 1012
xref: PTHR23220:SF9
organism: Canis lupus familiaris

uniprot A0A3Q1LWV5 669
type: UnificationXref
id: A0A3Q1LWV5
db: uniprot

uniprot P15064 317
type: UnificationXref
id: P15064
db: uniprot

uniprot H2PZQ7 302
type: UnificationXref
id: H2PZQ7
db: uniprot

Cdc42 protein, putative
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot B7PHY7 962
organism: Ixodes scapularis

Laminin subunit beta-2
type: ProteinReference
xref: uniprot Q61292 1239
xref: PTHR10574:SF36
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r106
controller: B-Raf

STATE TRANSITION LEFT Complex Integrin beta Integrin alpha Paxillin FAK Talin Vinculin Actin Integrin alpha alpha actinin Actin Integrin beta Filamin Collagen Laminin Fibronectin -RIGHT FAK- r76
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 1541
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 1540
left: Complex (Integrin beta/Integrin _alpha/ Paxillin/FAK/ Talin/Vinculin/ Actin/Integrin _alpha/ alpha actinin/Actin/ Integrin beta/Filamin/ Collagen/Laminin/ Fibronectin)
display name: STATE_TRANSITION_LEFT__Complex__Integrin_beta_Integrin__alpha__Paxillin_FAK__Talin_Vinculin__Actin_Integrin__alpha__alpha_actinin_Actin__Integrin_beta_Filamin__Collagen_Laminin__Fibronectin_-RIGHT__FAK-_r76
interaction type: STATE_TRANSITION
right: FAK

uniprot P38570 1066
type: UnificationXref
id: P38570
db: uniprot

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: uniprot Q05876 1100
xref: PTHR24418:SF44
organism: Gallus gallus

uniprot A0A3Q1MY30 1182
type: UnificationXref
id: A0A3Q1MY30
db: uniprot

uniprot A8X0X5 288
type: UnificationXref
id: A8X0X5
db: uniprot

Rho
type: Protein
entity reference: Rho
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q63844 157
type: UnificationXref
id: Q63844
db: uniprot

uniprot F1MSX4 104
type: UnificationXref
id: F1MSX4
db: uniprot

Collagen type XIV alpha 1 chain
type: ProteinReference
xref: uniprot E2RT85 428
xref: PTHR24020:SF15
organism: Canis lupus familiaris

Actin polymerization
type: Pathway

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: uniprot I0FRT6 128
organism: Macaca mulatta

uniprot C4M8B0 17
type: UnificationXref
id: C4M8B0
db: uniprot

PARTICIPANT STOICHIOMETRY r57 1614
type: Stoichiometry
physical entity: Complex (PIP2/Vinculin)
stoichiometric coefficient: 1.0

Integrin alpha
type: Protein
entity reference: Integrin alpha
feature: ACTIVE 89
feature: COMPLEX PARTICIPANT BINDING FEATURE s46 sa57 1394
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r57 1613
type: Stoichiometry
physical entity: Vinculin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r57 1612
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

uniprot Q14055 555
type: UnificationXref
id: Q14055
db: uniprot

Parvin alpha
type: ProteinReference
xref: uniprot A0A3Q1LMM6 1160
xref: PTHR12114:SF6
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5PE74 401
xref: PTHR24023:SF387
organism: Gallus gallus

Rac family small GTPase 3b
type: ProteinReference
xref: PTHR24072:SF301
xref: uniprot A9JRY8 683
organism: Danio rerio

PTHR23113:SF341
type: RelationshipXref
id: PTHR23113:SF341
db: PANTHER Family
relationship type: By Homology

uniprot Q60631 192
type: UnificationXref
id: Q60631
db: uniprot

uniprot Q14185 753
type: UnificationXref
id: Q14185
db: uniprot

uniprot P90904 181
type: UnificationXref
id: P90904
db: uniprot

Paxillin, isoform F
type: ProteinReference
xref: PTHR24216:SF8
xref: uniprot Q2PDT4 1324
organism: Drosophila melanogaster

HETERODIMER_ASSOCIATION_LEFT__SOS-_Grb2-_FAK-RIGHT__Complex__Grb2_SOS__FAK_-_r14
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 1521
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 1520
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 1522
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 1519
left: FAK
left: Grb2
left: SOS
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Grb2/SOS/ FAK)

Talin 1
type: ProteinReference
xref: PTHR19981:SF7
xref: uniprot F7CLM4 1106
organism: Ornithorhynchus anatinus

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: PTHR10048:SF29
xref: uniprot O70167 920
organism: Mus musculus

Shc
type: ProteinReference
xref: P00949
standard name: SH2 homology domain containing transforming protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Shc
comment: ENTITY_REFERENCE_NOTES=Long Name: SH2 domain containing oncogenic protein Synonym: SH2 domain containing oncogenic protein,Shc Accession: P00949
member entity reference: SHC-transforming protein 1
member entity reference: SHC (Src homology 2 domain containing) transforming protein 1
member entity reference: Uncharacterized protein
member entity reference: DShc protein

eco ECO:0000305 18
type: UnificationXref
id: ECO:0000305
db: eco

FAK s134 a146 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.851793120491741

uniprot Q2YDM1 613
type: UnificationXref
id: Q2YDM1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r109
controller: Ras

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: PTHR10048:SF29
xref: uniprot O70173 921
organism: Rattus norvegicus

Laminin
type: Protein
entity reference: Laminin
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa11 1494
comment: SPECIES_TYPE=PROTEIN

Collagen alpha-6(VI) chain
type: ProteinReference
xref: uniprot Q8C6K9 568
xref: PTHR22588:SF5
organism: Mus musculus

Collagen alpha-1(VI) chain
type: ProteinReference
xref: PTHR24020:SF18
xref: uniprot Q04857 547
organism: Mus musculus

Integrin subunit alpha 2b
type: ProteinReference
xref: PTHR23220:SF73
xref: uniprot D3ZAC0 1006
organism: Rattus norvegicus

uniprot A0A3Q1LWJ8 1329
type: UnificationXref
id: A0A3Q1LWJ8
db: uniprot

ncbitaxon 6945 590
type: UnificationXref
id: 6945
db: ncbitaxon

uniprot Q9VSL8 1111
type: UnificationXref
id: Q9VSL8
db: uniprot

uniprot K7DA60 1166
type: UnificationXref
id: K7DA60
db: uniprot

ITGA8 isoform 1
type: ProteinReference
xref: uniprot A0A2I3T8Z7 407
xref: PTHR23220:SF5
organism: Pan troglodytes

uniprot O15230 1215
type: UnificationXref
id: O15230
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot F6RFW8 1126
organism: Monodelphis domestica

RAP2A, member of RAS oncogene family a
type: ProteinReference
xref: PTHR24070:SF419
xref: uniprot E7F144 26
organism: Danio rerio

ADP-ribosylation factor 1
type: ProteinReference
xref: uniprot B7QCW2 589
xref: PTHR11711:SF381
organism: Ixodes scapularis

uniprot A0A2I3RZ64 405
type: UnificationXref
id: A0A2I3RZ64
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P42336 929
xref: PTHR10048:SF107
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot P42338 931
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P42337 930
xref: PTHR10048:SF107
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR24023:SF854
xref: uniprot F7EGF5 464
organism: Macaca mulatta

Phosphatidylinositol 3-kinase VPS34
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot P42339 932
organism: Arabidopsis thaliana

Integrin subunit alpha 6
type: ProteinReference
xref: PTHR23220:SF9
xref: uniprot G3V667 1034
organism: Rattus norvegicus

uniprot F6Z879 655
type: UnificationXref
id: F6Z879
db: uniprot

Paxillin s53 a132 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F1P859 372
xref: PTHR23113:SF150
organism: Canis lupus familiaris

uniprot Q9JHG7 952
type: UnificationXref
id: Q9JHG7
db: uniprot

uniprot E2R5G6 291
type: UnificationXref
id: E2R5G6
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot Q6PF93 943
xref: PTHR10048:SF7
organism: Mus musculus

uniprot P84078 610
type: UnificationXref
id: P84078
db: uniprot

Rho-related GTP-binding protein RhoE
type: ProteinReference
xref: PTHR24072:SF24
xref: uniprot Q6SA80 1301
organism: Rattus norvegicus

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q95ME4 331
organism: Monodelphis domestica

ncbitaxon 45351 287
type: UnificationXref
id: 45351
db: ncbitaxon

Fyn s377 a445 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fyn
stoichiometric coefficient: 1.0

Laminin subunit beta-1
type: ProteinReference
xref: PTHR10574:SF303
xref: uniprot P11046 1219
organism: Drosophila melanogaster

Laminin subunit gamma-1
type: ProteinReference
xref: uniprot P11047 1220
xref: PTHR10574:SF270
organism: Homo sapiens

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot F6W7C8 894
xref: PTHR10048:SF34
organism: Macaca mulatta

PTHR24023:SF980
type: RelationshipXref
id: PTHR24023:SF980
db: PANTHER Family
relationship type: By Homology

SOS
type: ProteinReference
xref: P00920
standard name: Son of sevenless
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Son of sevenless Synonym: SOS,Son of sevenless Accession: P00920
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.SOS
member entity reference: SOS Ras/Rho guanine nucleotide exchange factor 2
member entity reference: SOS Ras/Rac guanine nucleotide exchange factor 1
member entity reference: Son of sevenless homolog 1
member entity reference: Uncharacterized protein
member entity reference: Son of sevenless homolog 2
member entity reference: Protein son of sevenless

COL4A3 isoform 1
type: ProteinReference
xref: PTHR24023:SF980
xref: uniprot H2QJJ5 478
organism: Pan troglodytes

Integrin beta-4
type: ProteinReference
xref: uniprot Q64632 806
xref: PTHR10082:SF42
organism: Rattus norvegicus

uniprot E1BQI2 21
type: UnificationXref
id: E1BQI2
db: uniprot

Actinin, alpha 1
type: ProteinReference
xref: uniprot B8JHU4 712
xref: PTHR11915:SF425
organism: Danio rerio

PTHR24023:SF989
type: RelationshipXref
id: PTHR24023:SF989
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR23220:SF73
xref: uniprot F7E7I7 1028
organism: Macaca mulatta

uniprot O96692 55
type: UnificationXref
id: O96692
db: uniprot

Filamin A
type: ProteinReference
xref: uniprot C0JPT7 267
xref: PTHR38537:SF5
organism: Rattus norvegicus

Integrin beta
type: ProteinReference
xref: uniprot E2RT60 766
xref: PTHR10082:SF28
organism: Canis lupus familiaris

uniprot F6Y841 895
type: UnificationXref
id: F6Y841
db: uniprot

Integrin alpha-IIb
type: ProteinReference
xref: PTHR23220:SF73
xref: uniprot Q9QUM0 1084
organism: Mus musculus

Integrin beta-6
type: ProteinReference
xref: uniprot Q8SQB8 811
xref: PTHR10082:SF11
organism: Bos taurus

uniprot Q28G68 74
type: UnificationXref
id: Q28G68
db: uniprot

Tyrosine-protein phosphatase non-receptor type 12
type: ProteinReference
xref: PTHR45983:SF3
xref: uniprot F7EGH9 279
organism: Macaca mulatta

PTHR11937:SF176
type: RelationshipXref
id: PTHR11937:SF176
db: PANTHER Family
relationship type: By Homology

uniprot F1PXD3 652
type: UnificationXref
id: F1PXD3
db: uniprot

ADP ribosylation factor like GTPase 1
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot H2Q6P9 602
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot F7BBM1 897
organism: Monodelphis domestica

uniprot F1PG08 440
type: UnificationXref
id: F1PG08
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12771:SF8
xref: uniprot E1C122 335
organism: Gallus gallus

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q9XT09 165
xref: PTHR48013:SF5
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r109 1601
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

uniprot Q9V400 861
type: UnificationXref
id: Q9V400
db: uniprot

PARTICIPANT STOICHIOMETRY r109 1600
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

Arf6
type: Protein
entity reference: Arf6
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q13753 1229
type: UnificationXref
id: Q13753
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F073 49
organism: Monodelphis domestica

uniprot F6QWB7 1124
type: UnificationXref
id: F6QWB7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SPW3 446
xref: PTHR24023:SF539
organism: Monodelphis domestica

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r108
controller: Complex (Grb2/SOS/ FAK)

uniprot Q7ZSZ9 704
type: UnificationXref
id: Q7ZSZ9
db: uniprot

Fibronectin
type: ProteinReference
xref: uniprot P07589 978
xref: PTHR19143:SF267
organism: Bos taurus

PTHR11937:SF168
type: RelationshipXref
id: PTHR11937:SF168
db: PANTHER Family
relationship type: By Homology

MODULATION
type: Control
xref: MODULATION
controller: Complex (Integrin beta/Integrin _alpha/ Integrin beta/Integrin _alpha/ Collagen/Laminin/ Fibronectin)

Complex (ILK/PINCH/ Parvin)
type: Complex
component stoichiometry: Parvin s62 sa89 STOICHIOMETRY ID COMPLEX
component stoichiometry: ILK s60 sa87 STOICHIOMETRY ID COMPLEX
component stoichiometry: PINCH s61 sa88 STOICHIOMETRY ID COMPLEX
component: PINCH
component: ILK
component: Parvin
feature: COMPLEX BINDING FEATURE s337 a557 1485
feature: COMPLEX BINDING FEATURE s337 a557 1489
feature: COMPLEX BINDING FEATURE s337 a557 1487
cellular location: cytoplasm

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q4KLF8 238
xref: PTHR12644:SF1
organism: Rattus norvegicus

Dedicator of cyto-kinesis 1
type: ProteinReference
xref: uniprot D3ZZW1 749
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR24023:SF569
xref: uniprot F7CV32 462
organism: Monodelphis domestica

uniprot E2QUQ0 714
type: UnificationXref
id: E2QUQ0
db: uniprot

uniprot D3ZFJ0 874
type: UnificationXref
id: D3ZFJ0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SY88 599
xref: PTHR11711:SF357
organism: Monodelphis domestica

ASAP1
type: Protein
entity reference: ASAP1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F6SUP3 718
type: UnificationXref
id: F6SUP3
db: uniprot

uniprot P56199 1069
type: UnificationXref
id: P56199
db: uniprot

uniprot A0A3Q1LVP1 818
type: UnificationXref
id: A0A3Q1LVP1
db: uniprot

uniprot Q9VQD8 252
type: UnificationXref
id: Q9VQD8
db: uniprot

uniprot Q8C6K9 568
type: UnificationXref
id: Q8C6K9
db: uniprot

Collagen type VI alpha 3 chain
type: ProteinReference
xref: uniprot H2QJP2 479
xref: PTHR24020:SF13
organism: Pan troglodytes

MAP2K1 protein
type: ProteinReference
xref: uniprot Q0VD16 146
xref: PTHR48013:SF5
organism: Bos taurus

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot J9P5W6 129
xref: PTHR48013:SF5
organism: Canis lupus familiaris

uniprot Q9QYM5 1311
type: UnificationXref
id: Q9QYM5
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F6QUW1 374
xref: PTHR23113:SF168
organism: Monodelphis domestica

uniprot F7GJG7 190
type: UnificationXref
id: F7GJG7
db: uniprot

uniprot F6YT39 38
type: UnificationXref
id: F6YT39
db: uniprot

uniprot P62836 71
type: UnificationXref
id: P62836
db: uniprot

uniprot F7DH11 47
type: UnificationXref
id: F7DH11
db: uniprot

uniprot Q8IP51 1243
type: UnificationXref
id: Q8IP51
db: uniprot

uniprot E1C8Y3 206
type: UnificationXref
id: E1C8Y3
db: uniprot

Actin
type: Protein
entity reference: Actin
feature: COMPLEX PARTICIPANT BINDING FEATURE s69 sa75 1464
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3TRY9 869
type: UnificationXref
id: A0A2I3TRY9
db: uniprot

uniprot F1PBB6 651
type: UnificationXref
id: F1PBB6
db: uniprot

Arf family GTPase
type: ProteinReference
xref: uniprot Q5AND9 614
xref: PTHR11711:SF30
organism: Candida albicans

uniprot F1PMN2 107
type: UnificationXref
id: F1PMN2
db: uniprot

uniprot F7CV32 462
type: UnificationXref
id: F7CV32
db: uniprot

uniprot P41240 262
type: UnificationXref
id: P41240
db: uniprot

uniprot D3Z8L7 289
type: UnificationXref
id: D3Z8L7
db: uniprot

uniprot A0A2I3RP73 852
type: UnificationXref
id: A0A2I3RP73
db: uniprot

uniprot E2R2K4 25
type: UnificationXref
id: E2R2K4
db: uniprot

uniprot F1A1N6 595
type: UnificationXref
id: F1A1N6
db: uniprot

uniprot P61587 1280
type: UnificationXref
id: P61587
db: uniprot

uniprot A0JNB0 1092
type: UnificationXref
id: A0JNB0
db: uniprot

Paxillin
type: Protein
entity reference: Paxillin
feature: Paxillin s22 sa22 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa22 1406
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Paxillin
type: Protein
entity reference: Paxillin
feature: Paxillin s23 sa23 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa23 1412
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

FAK s66 sa72 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

Arp2/3
type: ProteinReference
xref: P00912
standard name: Actin related protein 2/3 complex
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Arp2/3
comment: ENTITY_REFERENCE_NOTES=Long Name: Arp2/3 Synonym: Actin related protein complex 2/3 Accession: P00912
member entity reference: Actin-related protein 2/3 complex subunit 5-like protein
member entity reference: Actin-related protein 2/3 complex subunit 3
member entity reference: Actin-related protein 2/3 complex subunit 5
member entity reference: Actin-related protein 2/3 complex subunit 1A
member entity reference: Actin-related protein 2/3 complex subunit
member entity reference: Actin-related protein 2/3 complex subunit 2
member entity reference: Actin-related protein 2/3 complex subunit 1B
member entity reference: Arp2/3 complex 34 kDa subunit

Laminin subunit gamma 3
type: ProteinReference
xref: uniprot A0A2I3TJK6 1180
xref: PTHR10574:SF240
organism: Pan troglodytes

uniprot O61444 661
type: UnificationXref
id: O61444
db: uniprot

Collagen alpha-1(I) chain
type: ProteinReference
xref: PTHR24023:SF569
xref: uniprot Q9XSJ7 580
organism: Canis lupus familiaris

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot K7CZM1 380
xref: PTHR23113:SF150
organism: Pan troglodytes

Collagen alpha-1(XI) chain
type: ProteinReference
xref: uniprot P12107 517
xref: PTHR24023:SF42
organism: Homo sapiens

Collagen alpha-1(VI) chain
type: ProteinReference
xref: uniprot P12109 518
xref: PTHR24020:SF18
organism: Homo sapiens

Collagen alpha-2(VI) chain
type: ProteinReference
xref: uniprot P12110 519
xref: PTHR24020:SF29
organism: Homo sapiens

Collagen alpha-3(VI) chain
type: ProteinReference
xref: uniprot P12111 520
xref: PTHR24020:SF13
organism: Homo sapiens

uniprot E2QVF3 100
type: UnificationXref
id: E2QVF3
db: uniprot

Integrin subunit alpha 7
type: ProteinReference
xref: uniprot F1PIU6 1020
xref: PTHR23220:SF90
organism: Canis lupus familiaris

uniprot Q22038 1288
type: UnificationXref
id: Q22038
db: uniprot

uniprot F6V4X2 360
type: UnificationXref
id: F6V4X2
db: uniprot

uniprot P02467 508
type: UnificationXref
id: P02467
db: uniprot

PARTICIPANT STOICHIOMETRY r76 1541
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r76 1540
type: Stoichiometry
physical entity: Complex (Integrin beta/Integrin _alpha/ Paxillin/FAK/ Talin/Vinculin/ Actin/Integrin _alpha/ alpha actinin/Actin/ Integrin beta/Filamin/ Collagen/Laminin/ Fibronectin)
stoichiometric coefficient: 1.0

PTHR11937:SF193
type: RelationshipXref
id: PTHR11937:SF193
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF192
type: RelationshipXref
id: PTHR11937:SF192
db: PANTHER Family
relationship type: By Homology

Filamin A
type: ProteinReference
xref: uniprot F1PWW0 270
xref: PTHR38537:SF5
organism: Canis lupus familiaris

uniprot Q8CFP6 85
type: UnificationXref
id: Q8CFP6
db: uniprot

Integrin alpha-1
type: ProteinReference
xref: uniprot P56199 1069
xref: PTHR23220:SF22
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A287AGL0 176
organism: Sus scrofa

ITGAM isoform 1
type: ProteinReference
xref: uniprot H2QB02 1038
xref: PTHR23220:SF130
organism: Pan troglodytes

uniprot P20702 1060
type: UnificationXref
id: P20702
db: uniprot

uniprot E9QAN8 883
type: UnificationXref
id: E9QAN8
db: uniprot

uniprot A0A0G2K6E0 1248
type: UnificationXref
id: A0A0G2K6E0
db: uniprot

GO GO:0005737 2
type: UnificationXref
id: GO:0005737
db: GO

uniprot A0A2I3RH39 866
type: UnificationXref
id: A0A2I3RH39
db: uniprot

uniprot Q8BPU7 345
type: UnificationXref
id: Q8BPU7
db: uniprot

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot A0A2I3TK00 196
xref: PTHR44329:SF47
organism: Pan troglodytes

Ras
type: Protein
entity reference: Ras
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

alpha actinin s43 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha actinin
stoichiometric coefficient: 1.0

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 24

Dedicator of cytokinesis protein 1
type: ProteinReference
xref: uniprot Q8BUR4 754
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR10574:SF291
xref: uniprot A0A1D5RDE7 1178
organism: Macaca mulatta

GRAF
type: ProteinReference
xref: P00926
standard name: GTPase regulator associated with FAK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: GTPase regulator associated with FAK Synonym: GRAF,GTPase regulator associated with FAK Accession: P00926
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.GRAF
member entity reference: Rho GTPase activating protein 26
member entity reference: Rho GTPase-activating protein 26
member entity reference: ARHGAP10 isoform 3
member entity reference: Rho GTPase-activating protein 10
member entity reference: ARHGAP26 isoform 1
member entity reference: Rho GTPase activating protein 26 (Predicted)
member entity reference: Uncharacterized protein
member entity reference: RCG51408

GTPase cRac1A
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q6LC82 702
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: PTHR12771:SF8
xref: uniprot F6TR56 337
organism: Monodelphis domestica

uniprot A7S9Y5 1253
type: UnificationXref
id: A7S9Y5
db: uniprot

uniprot F1P231 30
type: UnificationXref
id: F1P231
db: uniprot

uniprot P26450 926
type: UnificationXref
id: P26450
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot F6WR53 984
organism: Monodelphis domestica

Uncharacterized protein racC
type: ProteinReference
xref: PTHR24072:SF310
xref: uniprot F0ZN94 689
organism: Dictyostelium purpureum

Rho-related GTP-binding protein RhoB
type: ProteinReference
xref: uniprot P62745 1282
xref: PTHR24072:SF0
organism: Homo sapiens

Rho-related GTP-binding protein RhoB
type: ProteinReference
xref: uniprot P62747 1284
xref: PTHR24072:SF0
organism: Rattus norvegicus

Rho-related GTP-binding protein RhoB
type: ProteinReference
xref: uniprot P62746 1283
xref: PTHR24072:SF0
organism: Mus musculus

uniprot H2QQV4 1043
type: UnificationXref
id: H2QQV4
db: uniprot

uniprot G5EE56 987
type: UnificationXref
id: G5EE56
db: uniprot

uniprot F6PR50 109
type: UnificationXref
id: F6PR50
db: uniprot

uniprot A0A2I3RZ31 94
type: UnificationXref
id: A0A2I3RZ31
db: uniprot

Collagen, type VI, alpha 3
type: ProteinReference
xref: PTHR24020:SF13
xref: uniprot E9PWQ3 429
organism: Mus musculus

Integrin beta-2-like protein
type: ProteinReference
xref: PTHR10082:SF15
xref: uniprot Q3UV74 804
organism: Mus musculus

uniprot P05095 730
type: UnificationXref
id: P05095
db: uniprot

uniprot F6PXH5 653
type: UnificationXref
id: F6PXH5
db: uniprot

PTHR12644:SF0
type: RelationshipXref
id: PTHR12644:SF0
db: PANTHER Family
relationship type: By Homology

PTHR12644:SF1
type: RelationshipXref
id: PTHR12644:SF1
db: PANTHER Family
relationship type: By Homology

PTHR12644:SF2
type: RelationshipXref
id: PTHR12644:SF2
db: PANTHER Family
relationship type: By Homology

PTHR12644:SF3
type: RelationshipXref
id: PTHR12644:SF3
db: PANTHER Family
relationship type: By Homology

uniprot F7CCU2 1165
type: UnificationXref
id: F7CCU2
db: uniprot

uniprot K7AWV1 260
type: UnificationXref
id: K7AWV1
db: uniprot

uniprot A4FUD6 334
type: UnificationXref
id: A4FUD6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZZG9 1129
xref: PTHR11937:SF168
organism: Monodelphis domestica

Complex (Integrin beta/Integrin _alpha/ Integrin beta/Integrin _alpha/ Collagen/Laminin/ Fibronectin)
type: Complex
component stoichiometry: Fibronectin s9 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: Collagen s7 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Integrin alpha s2 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Integrin beta s1 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: Laminin s8 sa6 STOICHIOMETRY ID COMPLEX
component: Collagen
component: Fibronectin
component: Laminin
component: Integrin alpha
component: Integrin beta
feature: COMPLEX BINDING FEATURE s3 a5 1361
feature: COMPLEX BINDING FEATURE s3 a5 1365
feature: COMPLEX BINDING FEATURE s3 a5 1357
feature: COMPLEX BINDING FEATURE s3 a5 1363
feature: COMPLEX BINDING FEATURE s3 a5 1359
cellular location: cytoplasm

Collagen type XV alpha 1 chain
type: ProteinReference
xref: uniprot K7D0K0 495
xref: PTHR24023:SF912
organism: Pan troglodytes

Breast cancer anti-estrogen resistance protein 1
type: ProteinReference
xref: uniprot P56945 171
xref: PTHR10654:SF15
organism: Homo sapiens

uniprot D3ZVF3 876
type: UnificationXref
id: D3ZVF3
db: uniprot

Ras-related protein Rac1
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P40792 696
organism: Drosophila melanogaster

Cdc42 homolog
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot P40793 965
organism: Drosophila melanogaster

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot E2RSH8 983
organism: Canis lupus familiaris

uniprot D4A409 1189
type: UnificationXref
id: D4A409
db: uniprot

ADP-ribosylation factor 1
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot F1A1N6 595
organism: Dictyostelium purpureum

uniprot E2RL88 1012
type: UnificationXref
id: E2RL88
db: uniprot

uniprot Q6DHM9 1296
type: UnificationXref
id: Q6DHM9
db: uniprot

uniprot B0S602 972
type: UnificationXref
id: B0S602
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot Q9TXI7 953
xref: PTHR10048:SF7
organism: Caenorhabditis elegans

Protein-tyrosine kinase 2-beta
type: ProteinReference
xref: uniprot P70600 829
xref: PTHR24418:SF94
organism: Rattus norvegicus

uniprot P84077 609
type: UnificationXref
id: P84077
db: uniprot

uniprot F7GLS1 1029
type: UnificationXref
id: F7GLS1
db: uniprot

uniprot A0A2I3T1C0 999
type: UnificationXref
id: A0A2I3T1C0
db: uniprot

Fibronectin s40 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fibronectin
stoichiometric coefficient: 1.0

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF0
xref: uniprot E1C8Y3 206
organism: Gallus gallus

uniprot O08908 917
type: UnificationXref
id: O08908
db: uniprot

Actin, aortic smooth muscle
type: ProteinReference
xref: uniprot P62739 1142
xref: PTHR11937:SF445
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Paxillin-RIGHT__Paxillin-_r30
controller: FAK

Arp2/3
type: Protein
entity reference: Arp2/3
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot E2RGQ1 822
type: UnificationXref
id: E2RGQ1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24023:SF714
xref: uniprot F6XEQ9 452
organism: Macaca mulatta

PTHR11711:SF322
type: RelationshipXref
id: PTHR11711:SF322
db: PANTHER Family
relationship type: By Homology

Laminin subunit alpha-4
type: ProteinReference
xref: uniprot Q16363 1230
xref: PTHR15036:SF47
organism: Homo sapiens

PTHR24070:SF189
type: RelationshipXref
id: PTHR24070:SF189
db: PANTHER Family
relationship type: By Homology

Integrin beta
type: ProteinReference
xref: PTHR10082:SF28
xref: uniprot F6PNT9 771
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VDT1 674
xref: PTHR12552:SF4
organism: Macaca mulatta

PIP2
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s91 sa100 1370
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2QDN0 124
type: UnificationXref
id: H2QDN0
db: uniprot

PARTICIPANT STOICHIOMETRY r81 1513
type: Stoichiometry
physical entity: Complex (Abl/Paxillin)
stoichiometric coefficient: 1.0

PTHR24070:SF194
type: RelationshipXref
id: PTHR24070:SF194
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r81 1511
type: Stoichiometry
physical entity: Abl
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r81 1512
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

GTPase KRas
type: ProteinReference
xref: uniprot F6Z5N3 298
xref: PTHR24070:SF388
organism: Monodelphis domestica

uniprot Q6RUV5 703
type: UnificationXref
id: Q6RUV5
db: uniprot

uniprot Q9XT09 165
type: UnificationXref
id: Q9XT09
db: uniprot

uniprot O70309 784
type: UnificationXref
id: O70309
db: uniprot

uniprot H2QJP2 479
type: UnificationXref
id: H2QJP2
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot A0A1D5QKD3 93
organism: Macaca mulatta

Integrin alpha-PS2
type: ProteinReference
xref: uniprot P12080 1055
xref: PTHR23220:SF83
organism: Drosophila melanogaster

uniprot P04049 634
type: UnificationXref
id: P04049
db: uniprot

Filamin
type: Protein
entity reference: Filamin
feature: COMPLEX PARTICIPANT BINDING FEATURE s74 sa80 1468
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot P48736 933
xref: PTHR10048:SF34
organism: Homo sapiens

Laminin subunit beta-3
type: ProteinReference
xref: uniprot Q13751 1228
xref: PTHR10574:SF268
organism: Homo sapiens

Laminin subunit gamma-2
type: ProteinReference
xref: PTHR10574:SF313
xref: uniprot Q13753 1229
organism: Homo sapiens

uniprot Q6NYD8 620
type: UnificationXref
id: Q6NYD8
db: uniprot

uniprot Q9NZQ0 87
type: UnificationXref
id: Q9NZQ0
db: uniprot

uniprot Q7ZWH4 244
type: UnificationXref
id: Q7ZWH4
db: uniprot

uniprot P08120 511
type: UnificationXref
id: P08120
db: uniprot

Integrin subunit alpha 8
type: ProteinReference
xref: uniprot A0A3Q1MT97 413
xref: PTHR23220:SF5
organism: Bos taurus

ELMO
type: Protein
entity reference: ELMO
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Integrin alpha s46 sa57 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Integrin alpha
stoichiometric coefficient: 2.0

uniprot Q6NVA9 1154
type: UnificationXref
id: Q6NVA9
db: uniprot

uniprot P05997 510
type: UnificationXref
id: P05997
db: uniprot

PTHR11711:SF340
type: RelationshipXref
id: PTHR11711:SF340
db: PANTHER Family
relationship type: By Homology

uniprot Q3B7N2 737
type: UnificationXref
id: Q3B7N2
db: uniprot

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 14

Uncharacterized protein
type: ProteinReference
xref: uniprot F6V2H6 113
xref: PTHR24055:SF171
organism: Monodelphis domestica

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: uniprot P27986 927
xref: PTHR10155:SF3
organism: Homo sapiens

Collagen
type: Protein
entity reference: Collagen
feature: COMPLEX PARTICIPANT BINDING FEATURE s55 sa61 1398
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q0IIE2 1317
type: UnificationXref
id: Q0IIE2
db: uniprot

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot H9FYU7 379
xref: PTHR23113:SF150
organism: Macaca mulatta

uniprot P17140 527
type: UnificationXref
id: P17140
db: uniprot

uniprot Q9UNA1 682
type: UnificationXref
id: Q9UNA1
db: uniprot

V-crk avian sarcoma virus CT10 oncogene homolog
type: ProteinReference
xref: uniprot F6XER9 838
xref: PTHR19969:SF8
organism: Xenopus tropicalis

uniprot E1BMX0 290
type: UnificationXref
id: E1BMX0
db: uniprot

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot E9QAN8 883
organism: Mus musculus

Arf1
type: ProteinReference
xref: P00923
standard name: ADP ribosylation factor 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: ADP ribosylation factor 1 Synonym: ARF1,Adenosine diphosphate ribosylation factor 1 Accession: P00923
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Arf1
member entity reference: ADP-ribosylation factor 1
member entity reference: Small ARF-related GTPase
member entity reference: Uncharacterized protein
member entity reference: ADP ribosylation factor like GTPase 1
member entity reference: ADP-ribosylation factor 2b
member entity reference: ADP ribosylation factor-like GTPase 1
member entity reference: ADP-ribosylation factor 2
member entity reference: ADP-ribosylation factor-like protein 1
member entity reference: ADP ribosylation factor 5
member entity reference: ADP ribosylation factor 1
member entity reference: Arf family GTPase
member entity reference: ADP-ribosylation factor-like 1
member entity reference: ADP-ribosylation factor A1F

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

Rho family GTPase 2
type: ProteinReference
xref: uniprot E2RKC5 1256
xref: PTHR24072:SF21
organism: Canis lupus familiaris

PTHR11711:SF357
type: RelationshipXref
id: PTHR11711:SF357
db: PANTHER Family
relationship type: By Homology

uniprot F6VAQ8 892
type: UnificationXref
id: F6VAQ8
db: uniprot

Integrin beta
type: ProteinReference
xref: uniprot F1MTN1 767
xref: PTHR10082:SF25
organism: Bos taurus

PTHR10337:SF2
type: RelationshipXref
id: PTHR10337:SF2
db: PANTHER Family
relationship type: By Homology

uniprot D3ZNT5 421
type: UnificationXref
id: D3ZNT5
db: uniprot

Fibronectin
type: ProteinReference
xref: P00939
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Fibronectin
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Fibronectin
member entity reference: Fibronectin 1
member entity reference: Fibronectin 1a
member entity reference: Uncharacterized protein
member entity reference: FN1 isoform 1

Filamin
type: ProteinReference
xref: P00914
comment: ENTITY_REFERENCE_NOTES=Long Name: Filamin Synonym: Synonym not specified Accession: P00914
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Filamin
member entity reference: Filamin B
member entity reference: Uncharacterized protein
member entity reference: Filamin-B
member entity reference: Filamin-A
member entity reference: Filamin-A isoform 2
member entity reference: Filamin A
member entity reference: FLNB isoform 8

COL8A1 protein
type: ProteinReference
xref: uniprot A7E303 416
xref: PTHR24023:SF903
organism: Bos taurus

uniprot Q62636 76
type: UnificationXref
id: Q62636
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DMS9 361
organism: Ornithorhynchus anatinus

HETERODIMER_ASSOCIATION_LEFT__SOS-_Grb2-_Shc-RIGHT__Complex__SOS_Grb2__Shc_-_r87
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 1626
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 1625
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 1623
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 1624
left: Shc
left: Grb2
left: SOS
interaction type: HETERODIMER_ASSOCIATION
right: Complex (SOS/Grb2/ Shc)

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
type: ProteinReference
xref: uniprot O00443 914
xref: PTHR10048:SF28
organism: Homo sapiens

uniprot P63261 1146
type: UnificationXref
id: P63261
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RKA7 102
organism: Canis lupus familiaris

ITGA1 isoform 1
type: ProteinReference
xref: uniprot H2QQV4 1043
xref: PTHR23220:SF22
organism: Pan troglodytes

uniprot A0A2I3TJK6 1180
type: UnificationXref
id: A0A2I3TJK6
db: uniprot

uniprot P36507 663
type: UnificationXref
id: P36507
db: uniprot

PTHR24072:SF192
type: RelationshipXref
id: PTHR24072:SF192
db: PANTHER Family
relationship type: By Homology

PTHR45983:SF3
type: RelationshipXref
id: PTHR45983:SF3
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: uniprot Q99683 161
organism: Homo sapiens

PI-3 kinase
type: ProteinReference
xref: uniprot P91634 938
xref: PTHR10048:SF14
organism: Drosophila melanogaster

uniprot F0ZI47 294
type: UnificationXref
id: F0ZI47
db: uniprot

Integrin alpha-9
type: ProteinReference
xref: PTHR23220:SF69
xref: uniprot Q13797 1074
organism: Homo sapiens

uniprot E9PWQ3 429
type: UnificationXref
id: E9PWQ3
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 59

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot O00459 915
organism: Homo sapiens

uniprot F7FWN9 986
type: UnificationXref
id: F7FWN9
db: uniprot

uniprot F1N7C3 371
type: UnificationXref
id: F1N7C3
db: uniprot

Y925 FAK s181 a240 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y925
feature location: Y925 FAK s181 a240 rs2 Y925
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.58380694263043
comment: MODIFICATION_RESIDUE_NAME=Y925

Paxillin
type: Protein
entity reference: Paxillin
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa28 1418
feature: Paxillin s28 sa28 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Integrin beta-6
type: ProteinReference
xref: uniprot P18564 794
xref: PTHR10082:SF11
organism: Homo sapiens

Integrin beta
type: ProteinReference
xref: uniprot F1NM67 769
xref: PTHR10082:SF15
organism: Gallus gallus

Paxillin
type: ProteinReference
xref: uniprot Q66H76 1325
xref: PTHR24216:SF11
organism: Rattus norvegicus

uniprot A8Y3R8 711
type: UnificationXref
id: A8Y3R8
db: uniprot

Netrin-4
type: ProteinReference
xref: uniprot F7A403 1202
xref: PTHR10574:SF282
organism: Macaca mulatta

PTHR24072:SF153
type: RelationshipXref
id: PTHR24072:SF153
db: PANTHER Family
relationship type: By Homology

MAP3K5 isoform 1
type: ProteinReference
xref: uniprot K7CFQ9 130
organism: Pan troglodytes

uniprot F1PT97 209
type: UnificationXref
id: F1PT97
db: uniprot

uniprot H2QS62 1339
type: UnificationXref
id: H2QS62
db: uniprot

Collagen alpha-1(X) chain
type: ProteinReference
xref: uniprot Q03692 546
xref: PTHR24023:SF880
organism: Homo sapiens

uniprot E2RBL9 765
type: UnificationXref
id: E2RBL9
db: uniprot

uniprot F1NSA8 29
type: UnificationXref
id: F1NSA8
db: uniprot

uniprot P18614 1058
type: UnificationXref
id: P18614
db: uniprot

Rap1
type: Protein
entity reference: Rap1
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

?
type: PhysicalEntity
cellular location: cytoplasm
comment: SPECIES_TYPE=UNKNOWN

Fibronectin s57 sa63 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fibronectin
stoichiometric coefficient: 1.0

uniprot P98083 1316
type: UnificationXref
id: P98083
db: uniprot

PTHR24072:SF169
type: RelationshipXref
id: PTHR24072:SF169
db: PANTHER Family
relationship type: By Homology

uniprot P62332 367
type: UnificationXref
id: P62332
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24023:SF42
xref: uniprot F6Z5U1 454
organism: Macaca mulatta

PTHR24072:SF168
type: RelationshipXref
id: PTHR24072:SF168
db: PANTHER Family
relationship type: By Homology

Integrin alpha-4
type: ProteinReference
xref: uniprot Q00651 1070
xref: PTHR23220:SF78
organism: Mus musculus

uniprot Q03135 353
type: UnificationXref
id: Q03135
db: uniprot

Protein-tyrosine kinase 2-beta
type: ProteinReference
xref: PTHR24418:SF94
xref: uniprot Q14289 832
organism: Homo sapiens

uniprot P62747 1284
type: UnificationXref
id: P62747
db: uniprot

PTHR24072:SF136
type: RelationshipXref
id: PTHR24072:SF136
db: PANTHER Family
relationship type: By Homology

MODULATION
type: Control
xref: MODULATION
controlled: Actin stress fibers
controller: Rho

uniprot Q9TXI7 953
type: UnificationXref
id: Q9TXI7
db: uniprot

uniprot E2RG67 593
type: UnificationXref
id: E2RG67
db: uniprot

uniprot P22981 320
type: UnificationXref
id: P22981
db: uniprot

p130CAS
type: Protein
entity reference: p130CAS
feature: p130CAS s20 sa20 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa20 1480
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 10116 20
type: UnificationXref
id: 10116
db: ncbitaxon

FAK
type: ProteinReference
xref: P00932
standard name: Focal Adhesion Kinase
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.FAK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Focal Adhesion Kinase Synonym: FAK,Focal adhesion kinase Accession: P00932
member entity reference: PTK2B isoform 2
member entity reference: Protein tyrosine kinase 2
member entity reference: Protein CBR-KIN-32
member entity reference: Protein tyrosine kinase 2 beta
member entity reference: Focal adhesion kinase 1
member entity reference: Protein-tyrosine kinase 2-beta
member entity reference: Protein tyrosine kinase 2ab
member entity reference: Inactive tyrosine-protein kinase kin-32
member entity reference: Uncharacterized protein

uniprot K7CW88 1213
type: UnificationXref
id: K7CW88
db: uniprot

Paxillin s25 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

uniprot P29353 1315
type: UnificationXref
id: P29353
db: uniprot

Integrin beta
type: ProteinReference
xref: PTHR10082:SF11
xref: uniprot A0A1D5QZT0 756
organism: Macaca mulatta

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Csk
type: Protein
entity reference: Csk
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Integrin beta-like protein 1
type: ProteinReference
xref: uniprot Q5PQQ8 805
xref: PTHR10082:SF3
organism: Rattus norvegicus

uniprot Q6AYF4 807
type: UnificationXref
id: Q6AYF4
db: uniprot

Protein tyrosine kinase 2
type: ProteinReference
xref: uniprot A0A3Q1N508 819
xref: PTHR24418:SF78
organism: Bos taurus

Actin, cytoplasmic type 5
type: ProteinReference
xref: uniprot P53478 1137
xref: PTHR11937:SF168
organism: Gallus gallus

Transforming protein RhoA
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot Q9QUI0 1310
organism: Mus musculus

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 18

PTHR24023:SF903
type: RelationshipXref
id: PTHR24023:SF903
db: PANTHER Family
relationship type: By Homology

uniprot Q28EW2 326
type: UnificationXref
id: Q28EW2
db: uniprot

Mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot A0A3S5ZPX3 646
organism: Bos taurus

uniprot P32252 321
type: UnificationXref
id: P32252
db: uniprot

Phosphatidylinositol 3-kinase 3
type: ProteinReference
xref: PTHR10048:SF48
xref: uniprot P54675 937
organism: Dictyostelium discoideum

Phosphatidylinositol 3-kinase 2
type: ProteinReference
xref: uniprot P54674 936
xref: PTHR10048:SF109
organism: Dictyostelium discoideum

Phosphatidylinositol 3-kinase 1
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot P54673 935
organism: Dictyostelium discoideum

uniprot E2RKQ1 389
type: UnificationXref
id: E2RKQ1
db: uniprot

B-Raf
type: ProteinReference
xref: P00911
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.B-Raf
comment: ENTITY_REFERENCE_NOTES=Long Name: B-Raf Synonym: Synonym not specified Accession: P00911
member entity reference: B-Raf proto-oncogene, serine/threonine kinase
member entity reference: Serine/threonine-protein kinase B-raf

PTHR24023:SF906
type: RelationshipXref
id: PTHR24023:SF906
db: PANTHER Family
relationship type: By Homology

uniprot Q60847 559
type: UnificationXref
id: Q60847
db: uniprot

uniprot F7BRK5 632
type: UnificationXref
id: F7BRK5
db: uniprot

uniprot Q7PXF5 1240
type: UnificationXref
id: Q7PXF5
db: uniprot

Collagen alpha-1(IX) chain
type: ProteinReference
xref: PTHR24023:SF918
xref: uniprot Q05722 550
organism: Mus musculus

uniprot A0A3Q1M7B6 1161
type: UnificationXref
id: A0A3Q1M7B6
db: uniprot

Collagen alpha-1(XIV) chain
type: ProteinReference
xref: uniprot Q05707 549
xref: PTHR24020:SF15
organism: Homo sapiens

PTHR24023:SF912
type: RelationshipXref
id: PTHR24023:SF912
db: PANTHER Family
relationship type: By Homology

uniprot H2QD72 1039
type: UnificationXref
id: H2QD72
db: uniprot

uniprot F6PQK0 1261
type: UnificationXref
id: F6PQK0
db: uniprot

Integrin beta s63 sa69 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Integrin beta
stoichiometric coefficient: 2.0

uniprot Q05397 831
type: UnificationXref
id: Q05397
db: uniprot

PTHR24023:SF917
type: RelationshipXref
id: PTHR24023:SF917
db: PANTHER Family
relationship type: By Homology

PTHR24023:SF918
type: RelationshipXref
id: PTHR24023:SF918
db: PANTHER Family
relationship type: By Homology

DnaJ homolog subfamily C member 27
type: ProteinReference
xref: uniprot Q6IML7 78
organism: Rattus norvegicus

Pi3K21B, isoform B
type: ProteinReference
xref: uniprot Q7KTZ2 945
xref: PTHR10155:SF10
organism: Drosophila melanogaster

COL20A1 isoform 3
type: ProteinReference
xref: uniprot H2R3F1 486
xref: PTHR24020:SF39
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q4B3 174
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QJY6 865
xref: PTHR10048:SF28
organism: Macaca mulatta

Rho-related GTP-binding protein Rho6
type: ProteinReference
xref: uniprot Q2HJ68 1291
xref: PTHR24072:SF23
organism: Bos taurus

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot K7AWV1 260
xref: PTHR24418:SF407
organism: Pan troglodytes

Neuronal proto-oncogene tyrosine-protein kinase Src
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot P05480 990
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YLW2 115
organism: Macaca mulatta

COL1A2 isoform 1
type: ProteinReference
xref: PTHR24023:SF568
xref: uniprot A0A2J8L483 410
organism: Pan troglodytes

uniprot H2R6B8 488
type: UnificationXref
id: H2R6B8
db: uniprot

Rho family GTPase 1
type: ProteinReference
xref: uniprot E2RS61 1258
xref: PTHR24072:SF23
organism: Canis lupus familiaris

DnaJ homolog subfamily C member 27
type: ProteinReference
xref: uniprot Q6IMM1 79
organism: Gallus gallus

Actin, beta-like 2
type: ProteinReference
xref: PTHR11937:SF168
xref: uniprot D3ZRN3 1121
organism: Rattus norvegicus

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: uniprot P28028 199
xref: PTHR44329:SF47
organism: Mus musculus

uniprot Q9V7A4 1089
type: UnificationXref
id: Q9V7A4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PNX7 598
xref: PTHR11711:SF41
organism: Monodelphis domestica

PTHR24072:SF105
type: RelationshipXref
id: PTHR24072:SF105
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r102
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r102 1622
participant stoichiometry: PARTICIPANT STOICHIOMETRY r102 1621
left: Rac
interaction type: STATE_TRANSITION
right: Rac

uniprot E2R5T9 716
type: UnificationXref
id: E2R5T9
db: uniprot

Tyrosine-protein phosphatase non-receptor type 12
type: ProteinReference
xref: uniprot P35831 282
xref: PTHR45983:SF3
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot E9I1I7 292
organism: Daphnia pulex

uniprot F1A084 690
type: UnificationXref
id: F1A084
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF446
xref: uniprot C3YC50 1120
organism: Branchiostoma floridae

Integrin alpha-11
type: ProteinReference
xref: PTHR23220:SF21
xref: uniprot Q9UKX5 1088
organism: Homo sapiens

ERK
type: ProteinReference
xref: P00907
standard name: Extracellular signal-regulated kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Extracellular signal-regulated kinase Synonym: Erk,Extracellular signal-regulated kinase Accession: P00907
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.ERK
member entity reference: MAPK6 isoform 1
member entity reference: Mitogen-activated protein kinase 10
member entity reference: MAP3K2 isoform 1
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Dual specificity mitogen-activated protein kinase kinase 1
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Mitogen-activated protein kinase kinase kinase 1
member entity reference: Mitogen-activated protein kinase
member entity reference: MAP3K5 isoform 1
member entity reference: Mitogen-activated protein kinase kinase kinase 2
member entity reference: Mitogen-activated protein kinase kinase kinase 3
member entity reference: Mitogen-activated protein kinase kinase kinase 4
member entity reference: Extracellular signal-regulated kinase 1
member entity reference: Mitogen-activated protein kinase kinase kinase 5
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase 6
member entity reference: Map3k3 protein
member entity reference: Mitogen-activated protein kinase kinase 1
member entity reference: MAP2K1 protein
member entity reference: Mitogen-activated protein kinase kinase kinase 3 isoform 1

PTHR24072:SF100
type: RelationshipXref
id: PTHR24072:SF100
db: PANTHER Family
relationship type: By Homology

Candida albicans
type: BioSource
xref: ncbitaxon 237561 150

LIM and senescent cell antigen-like-containing domain protein
type: ProteinReference
xref: PTHR24210:SF10
xref: uniprot A0A2I3T9A8 387
organism: Pan troglodytes

PTHR11711:SF379
type: RelationshipXref
id: PTHR11711:SF379
db: PANTHER Family
relationship type: By Homology

Fyn
type: Protein
entity reference: Fyn
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Jnk-RIGHT__Jnk-_r103
controller: Rac

Ras homolog family member C
type: ProteinReference
xref: uniprot A0A0G2K6E0 1248
xref: PTHR24072:SF100
organism: Rattus norvegicus

SHC-transforming protein 1
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot P98083 1316
organism: Mus musculus

PTHR23113:SF224
type: RelationshipXref
id: PTHR23113:SF224
db: PANTHER Family
relationship type: By Homology

DnaJ homolog subfamily C member 27
type: ProteinReference
xref: uniprot Q9NZQ0 87
organism: Homo sapiens

uniprot H2QMA4 1042
type: UnificationXref
id: H2QMA4
db: uniprot

uniprot E2RT60 766
type: UnificationXref
id: E2RT60
db: uniprot

FAK s134 a146 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.647709131634312
comment: MODIFICATION_RESIDUE_NAME=

PTHR11711:SF381
type: RelationshipXref
id: PTHR11711:SF381
db: PANTHER Family
relationship type: By Homology

uniprot H2R3F1 486
type: UnificationXref
id: H2R3F1
db: uniprot

uniprot G5E577 122
type: UnificationXref
id: G5E577
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24020:SF15
xref: uniprot F7HQD8 472
organism: Macaca mulatta

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 686

uniprot D3ZRN3 1121
type: UnificationXref
id: D3ZRN3
db: uniprot

uniprot F6YFL0 1026
type: UnificationXref
id: F6YFL0
db: uniprot

Integrin subunit alpha 5
type: ProteinReference
xref: PTHR23220:SF3
xref: uniprot H2Q644 1036
organism: Pan troglodytes

uniprot P11047 1220
type: UnificationXref
id: P11047
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Cdc42-RIGHT__Cdc42-_r98
control type: ACTIVATION
controller: ?

ASAP1
type: Protein
entity reference: ASAP1
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Collagen alpha-4(IV) chain
type: ProteinReference
xref: PTHR24023:SF714
xref: uniprot P53420 540
organism: Homo sapiens

ADP-ribosylation factor 1
type: ProteinReference
xref: uniprot Q6NT85 619
xref: PTHR11711:SF30
organism: Xenopus tropicalis

uniprot F6QM53 888
type: UnificationXref
id: F6QM53
db: uniprot

Collagen type I alpha 1 chain
type: ProteinReference
xref: PTHR24023:SF58
xref: uniprot F7BJV7 461
organism: Macaca mulatta

Integrin subunit alpha 7
type: ProteinReference
xref: PTHR23220:SF90
xref: uniprot H2Q659 1037
organism: Pan troglodytes

Rho family GTPase 1
type: ProteinReference
xref: uniprot H2Q5T9 1268
xref: PTHR24072:SF23
organism: Pan troglodytes

uniprot F1PIU6 1020
type: UnificationXref
id: F1PIU6
db: uniprot

Paxillin s65 sa71 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF393
xref: uniprot E2R2K4 25
organism: Canis lupus familiaris

uniprot P11688 1054
type: UnificationXref
id: P11688
db: uniprot

uniprot E1BDD5 1011
type: UnificationXref
id: E1BDD5
db: uniprot

Talin
type: Protein
entity reference: Talin
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa30 1422
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BDD5 1011
xref: PTHR23220:SF26
organism: Bos taurus

Actin, alpha skeletal muscle
type: ProteinReference
xref: uniprot P68138 1147
xref: PTHR11937:SF193
organism: Bos taurus

uniprot F6URW3 375
type: UnificationXref
id: F6URW3
db: uniprot

uniprot P62834 69
type: UnificationXref
id: P62834
db: uniprot

uniprot P18084 793
type: UnificationXref
id: P18084
db: uniprot

uniprot Q28BZ0 970
type: UnificationXref
id: Q28BZ0
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Csk-_Paxillin-RIGHT__Complex__Csk_Paxillin_-_r33
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1582
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1581
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1583
left: Csk
left: Paxillin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Csk/Paxillin)

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P79996 1344
organism: Gallus gallus

uniprot Q6Y5D8 680
type: UnificationXref
id: Q6Y5D8
db: uniprot

Phosphoinositide-3-kinase regulatory subunit 1
type: ProteinReference
xref: uniprot F1Q2Q9 886
xref: PTHR10155:SF3
organism: Canis lupus familiaris

PTHR23220:SF21
type: RelationshipXref
id: PTHR23220:SF21
db: PANTHER Family
relationship type: By Homology

PTHR23220:SF22
type: RelationshipXref
id: PTHR23220:SF22
db: PANTHER Family
relationship type: By Homology

PTHR23220:SF23
type: RelationshipXref
id: PTHR23220:SF23
db: PANTHER Family
relationship type: By Homology

uniprot A0NBA9 873
type: UnificationXref
id: A0NBA9
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot P63001 698
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR11915:SF432
xref: uniprot F7EL30 723
organism: Monodelphis domestica

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot P63000 697
organism: Homo sapiens

STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r94
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 1593
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 1592
left: Rac
interaction type: STATE_TRANSITION
right: Rac

PARTICIPANT STOICHIOMETRY r10 1546
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

uniprot Q7SY59 82
type: UnificationXref
id: Q7SY59
db: uniprot

PARTICIPANT STOICHIOMETRY r10 1545
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

PTHR23220:SF26
type: RelationshipXref
id: PTHR23220:SF26
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5PE74 401
type: UnificationXref
id: A0A1D5PE74
db: uniprot

uniprot Q6GL82 242
type: UnificationXref
id: Q6GL82
db: uniprot

Collagen alpha-1(IV) chain
type: ProteinReference
xref: PTHR24023:SF1005
xref: uniprot P08120 511
organism: Drosophila melanogaster

uniprot Q63767 173
type: UnificationXref
id: Q63767
db: uniprot

Collagen alpha-1(III) chain
type: ProteinReference
xref: PTHR24023:SF604
xref: uniprot P08121 512
organism: Mus musculus

Collagen alpha-2(IV) chain
type: ProteinReference
xref: PTHR24023:SF588
xref: uniprot P08122 513
organism: Mus musculus

Collagen alpha-2(I) chain
type: ProteinReference
xref: PTHR24023:SF568
xref: uniprot P08123 514
organism: Homo sapiens

Collagen alpha-1(XIII) chain
type: ProteinReference
xref: PTHR24023:SF871
xref: uniprot Q5TAT6 558
organism: Homo sapiens

uniprot Q6P023 159
type: UnificationXref
id: Q6P023
db: uniprot

uniprot P17139 526
type: UnificationXref
id: P17139
db: uniprot

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot P08134 1275
organism: Homo sapiens

uniprot Q9QVP9 834
type: UnificationXref
id: Q9QVP9
db: uniprot

Cdc42
type: Protein
entity reference: Cdc42
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q62245 385
type: UnificationXref
id: Q62245
db: uniprot

Fibronectin 1
type: ProteinReference
xref: uniprot F7EAN4 973
xref: PTHR19143:SF267
organism: Xenopus tropicalis

uniprot Q13905 748
type: UnificationXref
id: Q13905
db: uniprot

uniprot K7D7X0 179
type: UnificationXref
id: K7D7X0
db: uniprot

Ras-related protein R-Ras
type: ProteinReference
xref: PTHR24070:SF245
xref: uniprot P10301 315
organism: Homo sapiens

uniprot J9P309 224
type: UnificationXref
id: J9P309
db: uniprot

uniprot G5EDY0 906
type: UnificationXref
id: G5EDY0
db: uniprot

Shc
type: Protein
entity reference: Shc
feature: Shc s286 a420 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Collagen alpha-1(V) chain
type: ProteinReference
xref: PTHR24023:SF387
xref: uniprot O88207 497
organism: Mus musculus

uniprot Q9R1N9 577
type: UnificationXref
id: Q9R1N9
db: uniprot

RAP1B, member of RAS oncogene family
type: ProteinReference
xref: PTHR24070:SF393
xref: uniprot F6PQC9 34
organism: Ornithorhynchus anatinus

Laminin subunit gamma 2
type: ProteinReference
xref: PTHR10574:SF313
xref: uniprot H2Q0R2 1208
organism: Pan troglodytes

LAMC1 isoform 1
type: ProteinReference
xref: PTHR10574:SF270
xref: uniprot H2Q0R1 1207
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r92 1594
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

Engulfment and cell motility 1
type: ProteinReference
xref: uniprot G8CYZ7 341
xref: PTHR12771:SF23
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Arf6-RIGHT__Arf6-_r118
controller: ASAP1

uniprot P28481 535
type: UnificationXref
id: P28481
db: uniprot

Caveolin-1
type: ProteinReference
xref: PTHR10844:SF18
xref: uniprot P79132 352
organism: Bos taurus

Actin-related protein 2/3 complex subunit 5-like protein
type: ProteinReference
xref: uniprot Q9BPX5 246
xref: PTHR12644:SF2
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r92 1595
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot F7FG65 1097
organism: Monodelphis domestica

uniprot P0CQ42 313
type: UnificationXref
id: P0CQ42
db: uniprot

uniprot H2QV01 221
type: UnificationXref
id: H2QV01
db: uniprot

STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_r113
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r113 1566
participant stoichiometry: PARTICIPANT STOICHIOMETRY r113 1565
left: Rho
interaction type: STATE_TRANSITION
right: Rho

Dock180
type: ProteinReference
xref: P00930
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Dock180 Synonym: Synonym not specified Accession: P00930
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Dock180
member entity reference: Dedicator of cytokinesis protein 1
member entity reference: CED-5
member entity reference: Dedicator of cyto-kinesis 1
member entity reference: Uncharacterized protein
member entity reference: Dedicator of cytokinesis 1

uniprot B3RQZ1 587
type: UnificationXref
id: B3RQZ1
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 4

uniprot F7EFD0 48
type: UnificationXref
id: F7EFD0
db: uniprot

Arf1
type: Protein
entity reference: Arf1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F1MVW3 768
type: UnificationXref
id: F1MVW3
db: uniprot

uniprot Q80X19 567
type: UnificationXref
id: Q80X19
db: uniprot

ADP-ribosylation factor 1
type: ProteinReference
xref: uniprot B3RQZ1 587
xref: PTHR11711:SF30
organism: Trichoplax adhaerens

Collagen alpha-1(IX) chain
type: ProteinReference
xref: PTHR24023:SF918
xref: uniprot P20849 529
organism: Homo sapiens

uniprot E2RF34 336
type: UnificationXref
id: E2RF34
db: uniprot

Laminin subunit alpha 4
type: ProteinReference
xref: uniprot F1PR66 1198
xref: PTHR15036:SF47
organism: Canis lupus familiaris

Collagen alpha-1(IX) chain
type: ProteinReference
xref: PTHR24023:SF918
xref: uniprot F1NQ20 438
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PZI2 1199
xref: PTHR15036:SF47
organism: Macaca mulatta

uniprot P05539 509
type: UnificationXref
id: P05539
db: uniprot

uniprot P61211 607
type: UnificationXref
id: P61211
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FYA6 362
xref: PTHR11711:SF379
organism: Monodelphis domestica

uniprot P61585 1278
type: UnificationXref
id: P61585
db: uniprot

uniprot Q6P4Z2 564
type: UnificationXref
id: Q6P4Z2
db: uniprot

p130CAS s20 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p130CAS
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DWL1 1107
xref: PTHR19981:SF7
organism: Monodelphis domestica

Fyn
type: ProteinReference
xref: P00942
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Fyn Synonym: Synonym not specified Accession: P00942
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Fyn
member entity reference: Tyrosine-protein kinase
member entity reference: Tyrosine-protein kinase fynb
member entity reference: Tyrosine-protein kinase Fyn
member entity reference: Tyrosine-protein kinase fyna

uniprot Q9CX99 195
type: UnificationXref
id: Q9CX99
db: uniprot

Rho-related GTP-binding protein RhoE
type: ProteinReference
xref: PTHR24072:SF24
xref: uniprot P61587 1280
organism: Homo sapiens

Collagen, type IV, alpha 6
type: ProteinReference
xref: uniprot B1AVK5 419
xref: PTHR24023:SF533
organism: Mus musculus

PTHR23220:SF19
type: RelationshipXref
id: PTHR23220:SF19
db: PANTHER Family
relationship type: By Homology

Rho-related GTP-binding protein RhoE
type: ProteinReference
xref: PTHR24072:SF24
xref: uniprot P61588 1281
organism: Mus musculus

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: uniprot F1P750 106
organism: Canis lupus familiaris

Transforming protein RhoA
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot P61585 1278
organism: Bos taurus

Transforming protein RhoA
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot P61586 1279
organism: Homo sapiens

uniprot F6ZKB3 1337
type: UnificationXref
id: F6ZKB3
db: uniprot

uniprot Q03600 1071
type: UnificationXref
id: Q03600
db: uniprot

uniprot E1BKX7 268
type: UnificationXref
id: E1BKX7
db: uniprot

uniprot A0A2I3THL4 628
type: UnificationXref
id: A0A2I3THL4
db: uniprot

uniprot Q9HF54 1306
type: UnificationXref
id: Q9HF54
db: uniprot

uniprot H2QTL5 483
type: UnificationXref
id: H2QTL5
db: uniprot

Integrin signalling pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__p130CAS-RIGHT__p130CAS-_r36
pathway component: HETERODIMER_ASSOCIATION_LEFT__Abl-_Paxillin-RIGHT__Complex__Abl_Paxillin_-_r81
pathway component: HETERODIMER ASSOCIATION LEFT Complex Integrin beta Integrin alpha - Complex Fibronectin Laminin Collagen -RIGHT Complex Integrin beta Integrin alpha Integrin beta Integrin alpha Collagen Laminin Fibronectin - r45
pathway component: STATE_TRANSITION_LEFT__B_Raf-RIGHT__B_Raf-_r105
pathway component: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r110
pathway component: STATE_TRANSITION_LEFT__Shc-RIGHT__Shc-_r48
pathway component: MODULATION
pathway component: STATE_TRANSITION_LEFT__Src-RIGHT__Src-_re61
pathway component: HETERODIMER_ASSOCIATION_LEFT__PTP_PEST-_Paxillin-RIGHT__Complex__Paxillin_PTP_PEST_-_r35
pathway component: STATE_TRANSITION_LEFT__ASAP1-RIGHT__ASAP1-_r116
pathway component: STATE_TRANSITION_LEFT__FAK-RIGHT__FAK-_r10
pathway component: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r109
pathway component: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r31
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__PIP2_Vinculin_-_VASP-RIGHT__Complex__Vinculin_PIP2__VASP_-_r120
pathway component: STATE_TRANSITION_LEFT__Paxillin-RIGHT__Paxillin-_r30
pathway component: HETERODIMER ASSOCIATION LEFT Complex alpha actinin Actin - Filamin- Paxillin- Complex Integrin beta Integrin alpha Integrin beta Integrin alpha Collagen Laminin Fibronectin - Talin- Complex Vinculin Actin -RIGHT Complex Integrin alpha Paxillin Integrin beta Talin Vinculin Actin Integrin alpha alpha actinin Actin Integrin beta Filamin Collagen Laminin Fibronectin - r41
pathway component: STATE_TRANSITION_LEFT__PI3K-RIGHT__PIP2-_r32
pathway component: STATE_TRANSITION_LEFT__p130CAS-RIGHT__p130CAS-_r13
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__PIP2_Vinculin_-_Arp2_3-RIGHT__Complex__Vinculin_PIP2__Arp2_3_-_r119
pathway component: HETERODIMER_ASSOCIATION_LEFT__p130CAS-_C3G-_Crk-RIGHT__Complex__Crk_C3G__p130CAS_-_r20
pathway component: STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_r99
pathway component: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r89
pathway component: HETERODIMER_ASSOCIATION_LEFT__Crk-_Paxillin-RIGHT__Complex__Paxillin_Crk_-_r34
pathway component: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r102
pathway component: STATE_TRANSITION_LEFT__Jnk-RIGHT__Jnk-_r103
pathway component: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r94
pathway component: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r90
pathway component: STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r92
pathway component: STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r111
pathway component: STATE_TRANSITION_LEFT__Arf1-RIGHT__Arf1-_r117
pathway component: STATE_TRANSITION_LEFT__Rap1-RIGHT__Rap1-_r104
pathway component: HETERODIMER ASSOCIATION LEFT Complex Integrin beta Integrin alpha - Complex Fibronectin Laminin Collagen -RIGHT Complex Integrin beta Integrin alpha Integrin beta Integrin alpha Collagen Laminin Fibronectin - r46
pathway component: STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r107
pathway component: HETERODIMER_ASSOCIATION_LEFT__SOS-_Grb2-_FAK-RIGHT__Complex__Grb2_SOS__FAK_-_r14
pathway component: STATE_TRANSITION_LEFT__GRAF-RIGHT__GRAF-_r112
pathway component: HETERODIMER ASSOCIATION LEFT Complex ILK PINCH Parvin - FAK- Complex Integrin alpha Paxillin Integrin beta Talin Vinculin Actin Integrin alpha alpha actinin Actin Integrin beta Filamin Collagen Laminin Fibronectin -RIGHT Complex Integrin beta Integrin alpha Paxillin FAK Talin Vinculin Actin Integrin alpha alpha actinin Actin Integrin beta Filamin Collagen Laminin Fibronectin - r77
pathway component: HETERODIMER ASSOCIATION LEFT Complex Integrin beta Integrin alpha Integrin beta Integrin alpha Collagen Laminin Fibronectin - Caveolin-RIGHT Complex Integrin beta Integrin alpha Caveolin Integrin alpha Integrin beta Collagen Laminin Fibronectin - r49
pathway component: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r108
pathway component: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r106
pathway component: STATE TRANSITION LEFT Complex Integrin beta Integrin alpha Paxillin FAK Talin Vinculin Actin Integrin alpha alpha actinin Actin Integrin beta Filamin Collagen Laminin Fibronectin -RIGHT FAK- r76
pathway component: HETERODIMER_ASSOCIATION_LEFT__SOS-_Grb2-_Shc-RIGHT__Complex__SOS_Grb2__Shc_-_r87
pathway component: STATE_TRANSITION_LEFT__Arf6-RIGHT__Arf6-_r118
pathway component: STATE_TRANSITION_LEFT__Cdc42-RIGHT__Cdc42-_r98
pathway component: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r91
pathway component: STATE_TRANSITION_LEFT__Fyn-RIGHT__Fyn-_r88
pathway component: HETERODIMER_ASSOCIATION_LEFT__p130CAS-_Dock180-_ELMO-_Crk-RIGHT__Complex__p130CAS_Crk__Dock180_ELMO_-_r78
pathway component: HETERODIMER_ASSOCIATION_LEFT__Csk-_Paxillin-RIGHT__Complex__Csk_Paxillin_-_r33
pathway component: HETERODIMER_ASSOCIATION_LEFT__PIP2-_Vinculin-RIGHT__Complex__PIP2_Vinculin_-_r57
pathway component: STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_r113
xref: PANTHER Pathway P00034 1
comment: MODEL_NOTES=Panther Pathway: P00034 The integrin signalling pathway is triggered when integrins in the cell membrane bind to extracellular matrix components. Downstream events include actin reorganization and activation of MAPK and other signalling cascades. Medline=10446041 Medline=11017872 Medline=11707510 Medline=11807174 Medline=12640026 Medline=12743027 PMID: 10446041 PMID: 11017872 PMID: 11707510 PMID: 11807174 PMID: 12640026 PMID: 12743027

uniprot A0A2J8L483 410
type: UnificationXref
id: A0A2J8L483
db: uniprot

ncbitaxon 559292 308
type: UnificationXref
id: 559292
db: ncbitaxon

STATE_TRANSITION_LEFT__Paxillin-RIGHT__Paxillin-_r30
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 1591
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 1590
left: Paxillin
interaction type: STATE_TRANSITION
right: Paxillin

uniprot A7RU31 1114
type: UnificationXref
id: A7RU31
db: uniprot

uniprot P26011 796
type: UnificationXref
id: P26011
db: uniprot

uniprot Q922K9 993
type: UnificationXref
id: Q922K9
db: uniprot

uniprot F6ZGX8 299
type: UnificationXref
id: F6ZGX8
db: uniprot

Integrin beta
type: ProteinReference
xref: PTHR10082:SF25
xref: uniprot F7FG54 776
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR10574:SF36
xref: uniprot E1BDK6 1190
organism: Bos taurus

Abl
type: ProteinReference
xref: P00946
standard name: Abelson murine leukemia viral oncogene homolog 1
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Abl
comment: ENTITY_REFERENCE_NOTES=Long Name: Abelson protein kinase Synonym: c-Abl Accession: P00946
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Tyrosine-protein kinase
member entity reference: Tyrosine-protein kinase ABL1

AGAP007629-PA
type: ProteinReference
xref: uniprot Q7QJR9 1241
xref: PTHR10574:SF79
organism: Anopheles gambiae

uniprot A0A2I3T8I1 1179
type: UnificationXref
id: A0A2I3T8I1
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot Q04970 323
xref: PTHR24070:SF189
organism: Rattus norvegicus

Paxillin s22 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

EGF-like-domain, multiple 5 (Predicted)
type: ProteinReference
xref: uniprot D4A3L3 1188
xref: PTHR10574:SF298
organism: Rattus norvegicus

Complex (Integrin _alpha/Paxillin/ Integrin beta/Talin/ Vinculin/Actin/ Integrin _alpha/alpha actinin/ Actin/Integrin beta/ Filamin/Collagen/ Laminin/Fibronectin)
type: Complex
component stoichiometry: Collagen s38 sa38 STOICHIOMETRY ID COMPLEX
component stoichiometry: Paxillin s28 sa28 STOICHIOMETRY ID COMPLEX
component stoichiometry: Fibronectin s40 sa40 STOICHIOMETRY ID COMPLEX
component stoichiometry: Laminin s39 sa39 STOICHIOMETRY ID COMPLEX
component stoichiometry: Integrin alpha s27 sa27 STOICHIOMETRY ID COMPLEX
component stoichiometry: Filamin s37 sa37 STOICHIOMETRY ID COMPLEX
component stoichiometry: Vinculin s31 sa31 STOICHIOMETRY ID COMPLEX
component stoichiometry: Integrin beta s29 sa29 STOICHIOMETRY ID COMPLEX
component stoichiometry: Actin s32 sa32 STOICHIOMETRY ID COMPLEX
component stoichiometry: Talin s30 sa30 STOICHIOMETRY ID COMPLEX
component stoichiometry: alpha actinin s34 sa34 STOICHIOMETRY ID COMPLEX
component: Actin
component: alpha actinin
component: Vinculin
component: Paxillin
component: Filamin
component: Integrin alpha
component: Fibronectin
component: Collagen
component: Talin
component: Integrin beta
component: Laminin
feature: COMPLEX BINDING FEATURE s246 a361 1419
feature: COMPLEX BINDING FEATURE s246 a361 1433
feature: COMPLEX BINDING FEATURE s246 a361 1425
feature: COMPLEX BINDING FEATURE s246 a361 1435
feature: COMPLEX BINDING FEATURE s246 a361 1431
feature: COMPLEX BINDING FEATURE s246 a361 1421
feature: COMPLEX BINDING FEATURE s246 a361 1427
feature: COMPLEX BINDING FEATURE s246 a361 1415
feature: COMPLEX BINDING FEATURE s246 a361 1417
feature: COMPLEX BINDING FEATURE s246 a361 1429
feature: COMPLEX BINDING FEATURE s246 a361 1423
cellular location: cytoplasm

Ras homolog family member C
type: ProteinReference
xref: uniprot A0A2I3S4I6 1249
xref: PTHR24072:SF100
organism: Pan troglodytes

Protein CBR-KIN-32
type: ProteinReference
xref: uniprot A8XBU1 820
organism: Caenorhabditis briggsae

Caveolin-1
type: ProteinReference
xref: uniprot Q2QLF2 354
xref: PTHR10844:SF18
organism: Pan troglodytes

Vinculin
type: Protein
entity reference: Vinculin
feature: COMPLEX PARTICIPANT BINDING FEATURE s59 sa68 1410
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot Q07890 384
xref: PTHR23113:SF150
organism: Homo sapiens

Laminin subunit alpha 1
type: ProteinReference
xref: PTHR10574:SF409
xref: uniprot D4A409 1189
organism: Rattus norvegicus

uniprot J9P6K0 54
type: UnificationXref
id: J9P6K0
db: uniprot

Collagen type IV alpha 1 chain
type: ProteinReference
xref: PTHR24023:SF854
xref: uniprot F1MA59 432
organism: Rattus norvegicus

uniprot K7C8P4 493
type: UnificationXref
id: K7C8P4
db: uniprot

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot Q5F3W3 151
xref: PTHR24055:SF171
organism: Gallus gallus

uniprot P02459 502
type: UnificationXref
id: P02459
db: uniprot

Integrin beta
type: ProteinReference
xref: PTHR10082:SF11
xref: uniprot E2RBL9 765
organism: Canis lupus familiaris

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
type: ProteinReference
xref: uniprot Q9ULH1 188
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r89
controller: Complex (SOS/Grb2/ Shc)

p130CAS s183 a245 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.9229354047838125
comment: MODIFICATION_RESIDUE_NAME=

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 37

Rho GTPase-activating protein 26
type: ProteinReference
xref: uniprot Q5ZMW5 679
xref: PTHR12552:SF4
organism: Gallus gallus

uniprot Q5M824 1318
type: UnificationXref
id: Q5M824
db: uniprot

uniprot H2Q659 1037
type: UnificationXref
id: H2Q659
db: uniprot

uniprot F6TFL4 110
type: UnificationXref
id: F6TFL4
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot P04627 636
organism: Mus musculus

Mitogen-activated protein kinase kinase 4A
type: ProteinReference
xref: uniprot B1NA68 649
xref: PTHR48013:SF15
organism: Danio rerio

Integrin alpha-1
type: ProteinReference
xref: uniprot Q3V3R4 1075
xref: PTHR23220:SF22
organism: Mus musculus

alpha actinin
type: Protein
entity reference: alpha actinin
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa34 1428
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Collagen alpha-1(XVII) chain
type: ProteinReference
xref: uniprot Q07563 552
xref: PTHR24023:SF891
organism: Mus musculus

uniprot A0A2I3S562 1103
type: UnificationXref
id: A0A2I3S562
db: uniprot

Rho-related GTP-binding protein RhoN
type: ProteinReference
xref: PTHR24072:SF21
xref: uniprot F6PQK0 1261
organism: Macaca mulatta

PTHR24070:SF419
type: RelationshipXref
id: PTHR24070:SF419
db: PANTHER Family
relationship type: By Homology

uniprot Q9WUD9 995
type: UnificationXref
id: Q9WUD9
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 625
xref: PTHR44329:SF22
xref: uniprot P05625 637
organism: Gallus gallus

uniprot F7F5X1 301
type: UnificationXref
id: F7F5X1
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q9DGD9 1349
xref: PTHR24055:SF222
organism: Danio rerio

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot E2R9L4 101
organism: Canis lupus familiaris

uniprot A1A4S6 670
type: UnificationXref
id: A1A4S6
db: uniprot

uniprot P08121 512
type: UnificationXref
id: P08121
db: uniprot

LIM and senescent cell antigen-like-containing domain protein
type: ProteinReference
xref: uniprot F7GXP0 392
xref: PTHR24210:SF11
organism: Macaca mulatta

uniprot Q28GJ8 1289
type: UnificationXref
id: Q28GJ8
db: uniprot

uniprot P53712 800
type: UnificationXref
id: P53712
db: uniprot

uniprot O15144 226
type: UnificationXref
id: O15144
db: uniprot

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: uniprot Q9CVB6 248
xref: PTHR12058:SF0
organism: Mus musculus

uniprot F1MMH2 1016
type: UnificationXref
id: F1MMH2
db: uniprot

uniprot F6ZKG7 456
type: UnificationXref
id: F6ZKG7
db: uniprot

PTHR24070:SF424
type: RelationshipXref
id: PTHR24070:SF424
db: PANTHER Family
relationship type: By Homology

Y397 FAK s148 a172 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y397
feature location: Y397 FAK s148 a172 rs1 Y397
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y397
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4400218803743385

uniprot C4M8K6 688
type: UnificationXref
id: C4M8K6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Fyn-RIGHT__Fyn-_r88
controller: Complex (Integrin beta/Integrin _alpha/ Caveolin/Integrin _alpha/ Integrin beta/Collagen/ Laminin/Fibronectin)

PTHR24070:SF420
type: RelationshipXref
id: PTHR24070:SF420
db: PANTHER Family
relationship type: By Homology

Vinculin s90 sa99 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Vinculin
stoichiometric coefficient: 1.0

PTHR24070:SF423
type: RelationshipXref
id: PTHR24070:SF423
db: PANTHER Family
relationship type: By Homology

uniprot D3ZX71 423
type: UnificationXref
id: D3ZX71
db: uniprot

Talin 1
type: ProteinReference
xref: uniprot A0A2I3S562 1103
xref: PTHR19981:SF7
organism: Pan troglodytes

Engulfment and cell motility protein 1
type: ProteinReference
xref: PTHR12771:SF23
xref: uniprot Q8BPU7 345
organism: Mus musculus

Laminin s8 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Laminin
stoichiometric coefficient: 1.0

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot E2RC09 1093
organism: Canis lupus familiaris

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot O35904 918
organism: Mus musculus

uniprot Q92747 245
type: UnificationXref
id: Q92747
db: uniprot

STATE_TRANSITION_LEFT__GRAF-RIGHT__GRAF-_r112
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r112 1572
participant stoichiometry: PARTICIPANT STOICHIOMETRY r112 1573
left: GRAF
interaction type: STATE_TRANSITION
right: GRAF

Integrin alpha-E
type: ProteinReference
xref: uniprot P38570 1066
xref: PTHR23220:SF79
organism: Homo sapiens

uniprot F6U132 212
type: UnificationXref
id: F6U132
db: uniprot

Grb2 s85 sa65 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

RAP2B, member of RAS oncogene family
type: ProteinReference
xref: PTHR24070:SF194
xref: uniprot Q28G68 74
organism: Xenopus tropicalis

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: uniprot A0A3Q1LPF2 95
organism: Bos taurus

C3G
type: ProteinReference
xref: P00929
standard name: CRK SH3 domain-binding guanine nucleotide-releasing factor
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.C3G
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: CRK SH3 domain-binding guanine nucleotide-releasing factor Synonym: C3G,CRK SH3 domain-binding guanine nucleotide-releasing factor Accession: P00929
member entity reference: Rap guanine nucleotide exchange factor 1
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-releasing factor 2

Integrin beta-2
type: ProteinReference
xref: uniprot P11835 791
xref: PTHR10082:SF15
organism: Mus musculus

Puccinia graminis
type: BioSource
xref: ncbitaxon 418459 1123

Collagen type V alpha 2 chain
type: ProteinReference
xref: PTHR24023:SF539
xref: uniprot F1PG08 440
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r107
controller: MEK

PTHR23220:SF79
type: RelationshipXref
id: PTHR23220:SF79
db: PANTHER Family
relationship type: By Homology

B-Raf
type: Protein
entity reference: B-Raf
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot D4A3T0 369
xref: PTHR23113:SF168
organism: Rattus norvegicus

uniprot F7GAP5 904
type: UnificationXref
id: F7GAP5
db: uniprot

PTHR23220:SF78
type: RelationshipXref
id: PTHR23220:SF78
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION
type: RelationshipTypeVocabulary

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MKG2 434
xref: PTHR24020:SF29
organism: Bos taurus

PTHR23220:SF73
type: RelationshipXref
id: PTHR23220:SF73
db: PANTHER Family
relationship type: By Homology

uniprot Q9HE04 1305
type: UnificationXref
id: Q9HE04
db: uniprot

uniprot F6ZE26 40
type: UnificationXref
id: F6ZE26
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot E2RIF9 881
xref: PTHR10048:SF7
organism: Canis lupus familiaris

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot B2GV73 205
xref: PTHR12391:SF1
organism: Rattus norvegicus

uniprot L7N2N3 496
type: UnificationXref
id: L7N2N3
db: uniprot

MAPK6 isoform 1
type: ProteinReference
xref: uniprot H2Q9G3 123
xref: PTHR24055:SF171
organism: Pan troglodytes

PTHR23220:SF69
type: RelationshipXref
id: PTHR23220:SF69
db: PANTHER Family
relationship type: By Homology

Complex (Paxillin/PTP-PEST)
type: Complex
component stoichiometry: PTP PEST s26 sa26 STOICHIOMETRY ID COMPLEX
component stoichiometry: Paxillin s25 sa25 STOICHIOMETRY ID COMPLEX
component: Paxillin
component: PTP-PEST
feature: COMPLEX BINDING FEATURE s218 a315 1481
feature: ACTIVE 89
feature: COMPLEX BINDING FEATURE s218 a315 1483
cellular location: cytoplasm

uniprot A4D0S4 1185
type: UnificationXref
id: A4D0S4
db: uniprot

uniprot Q1JP79 234
type: UnificationXref
id: Q1JP79
db: uniprot

STATE_TRANSITION_LEFT__Rap1-RIGHT__Rap1-_r104
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 1610
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 1611
left: Rap1
interaction type: STATE_TRANSITION
right: Rap1

Integrin subunit alpha 10
type: ProteinReference
xref: uniprot F6XF95 1024
xref: PTHR23220:SF26
organism: Canis lupus familiaris

ELMO s81 sa93 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ELMO
stoichiometric coefficient: 1.0

uniprot Q5ZHX1 75
type: UnificationXref
id: Q5ZHX1
db: uniprot

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot P15153 692
organism: Homo sapiens

uniprot Q9JI91 742
type: UnificationXref
id: Q9JI91
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 204

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 182

Vinculin s68 sa74 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Vinculin
stoichiometric coefficient: 1.0

uniprot A0A1D5QWF4 175
type: UnificationXref
id: A0A1D5QWF4
db: uniprot

uniprot P25067 531
type: UnificationXref
id: P25067
db: uniprot

uniprot A0A1D5RJ76 815
type: UnificationXref
id: A0A1D5RJ76
db: uniprot

uniprot P24043 1223
type: UnificationXref
id: P24043
db: uniprot

Map3k3 protein
type: ProteinReference
xref: uniprot B5DF98 97
organism: Rattus norvegicus

Actinin alpha 1
type: ProteinReference
xref: PTHR11915:SF434
xref: uniprot E2QY08 715
organism: Canis lupus familiaris

uniprot P60953 968
type: UnificationXref
id: P60953
db: uniprot

Son of sevenless homolog 1
type: ProteinReference
xref: uniprot Q07889 383
xref: PTHR23113:SF168
organism: Homo sapiens

PTHR23220:SF90
type: RelationshipXref
id: PTHR23220:SF90
db: PANTHER Family
relationship type: By Homology

Collagen alpha-2(I) chain
type: ProteinReference
xref: PTHR24023:SF568
xref: uniprot Q01149 543
organism: Mus musculus

uniprot A0A1D5RDE7 1178
type: UnificationXref
id: A0A1D5RDE7
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot O08908 917
organism: Mus musculus

uniprot F7B5L8 1338
type: UnificationXref
id: F7B5L8
db: uniprot

SOS
type: Protein
entity reference: SOS
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR23220:SF84
type: RelationshipXref
id: PTHR23220:SF84
db: PANTHER Family
relationship type: By Homology

PTHR23220:SF83
type: RelationshipXref
id: PTHR23220:SF83
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__Abl-_Paxillin-RIGHT__Complex__Abl_Paxillin_-_r81
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 1511
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 1513
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 1512
left: Abl
left: Paxillin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Abl/Paxillin)

uniprot A0A1D5RJA5 998
type: UnificationXref
id: A0A1D5RJA5
db: uniprot

uniprot Q62469 1079
type: UnificationXref
id: Q62469
db: uniprot

PTHR23220:SF89
type: RelationshipXref
id: PTHR23220:SF89
db: PANTHER Family
relationship type: By Homology

GTP-binding protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot O93467 1273
organism: Gallus gallus

uniprot F7B9T3 44
type: UnificationXref
id: F7B9T3
db: uniprot

GTP-binding protein
type: ProteinReference
xref: uniprot O93468 1274
xref: PTHR24072:SF0
organism: Gallus gallus

Ras homolog family member A
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot Q28GJ8 1289
organism: Xenopus tropicalis

STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r108
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r108 1602
participant stoichiometry: PARTICIPANT STOICHIOMETRY r108 1603
left: Ras
interaction type: STATE_TRANSITION
right: Ras

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot Q63789 941
organism: Rattus norvegicus

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot Q63788 940
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION_LEFT__Crk-_Paxillin-RIGHT__Complex__Paxillin_Crk_-_r34
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1576
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1574
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1575
left: Crk
left: Paxillin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Paxillin/Crk)

Uncharacterized protein
type: ProteinReference
xref: PTHR23113:SF224
xref: uniprot F7HBI2 746
organism: Macaca mulatta

Fibronectin
type: Protein
entity reference: Fibronectin
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa10 1492
comment: SPECIES_TYPE=PROTEIN

uniprot F1N789 955
type: UnificationXref
id: F1N789
db: uniprot

Vinculin
type: ProteinReference
xref: PTHR46180:SF1
xref: uniprot P18206 959
organism: Homo sapiens

Collagen, type I, alpha 1
type: ProteinReference
xref: PTHR24023:SF569
xref: uniprot L7N2N3 496
organism: Xenopus tropicalis

Integrin alpha-8
type: ProteinReference
xref: uniprot P53708 541
xref: PTHR23220:SF5
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot E1BE66 878
organism: Bos taurus

uniprot Q9JI33 1245
type: UnificationXref
id: Q9JI33
db: uniprot

Paxillin s25 sa25 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Paxillin s28 sa28 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ADP-ribosylation factor 6
type: ProteinReference
xref: PTHR11711:SF379
xref: uniprot P62331 366
organism: Mus musculus

ADP-ribosylation factor 6
type: ProteinReference
xref: PTHR11711:SF379
xref: uniprot P62332 367
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION_LEFT__Complex__PIP2_Vinculin_-_Arp2_3-RIGHT__Complex__Vinculin_PIP2__Arp2_3_-_r119
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r119 1554
participant stoichiometry: PARTICIPANT STOICHIOMETRY r119 1555
participant stoichiometry: PARTICIPANT STOICHIOMETRY r119 1556
left: Arp2/3
left: Complex (PIP2/Vinculin)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Vinculin/PIP2/ Arp2/3)

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YN59 750
organism: Macaca mulatta

ADP-ribosylation factor 6
type: ProteinReference
xref: uniprot P62330 365
xref: PTHR11711:SF379
organism: Homo sapiens

uniprot G5EGA4 473
type: UnificationXref
id: G5EGA4
db: uniprot

uniprot F6RLV0 358
type: UnificationXref
id: F6RLV0
db: uniprot

Collagen type XI alpha 2 chain
type: ProteinReference
xref: PTHR24023:SF509
xref: uniprot F6T0B3 447
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r31 1588
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r31 1589
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR12771:SF23
xref: uniprot A0A3Q1MHU3 333
organism: Bos taurus

PTHR23113:SF168
type: RelationshipXref
id: PTHR23113:SF168
db: PANTHER Family
relationship type: By Homology

uniprot F1P241 837
type: UnificationXref
id: F1P241
db: uniprot

uniprot Q9BPX5 246
type: UnificationXref
id: Q9BPX5
db: uniprot

uniprot Q7PVR8 566
type: UnificationXref
id: Q7PVR8
db: uniprot

uniprot P46734 665
type: UnificationXref
id: P46734
db: uniprot

uniprot Q9P8V0 1308
type: UnificationXref
id: Q9P8V0
db: uniprot

uniprot Q7PMF0 946
type: UnificationXref
id: Q7PMF0
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot P45985 664
xref: PTHR48013:SF20
organism: Homo sapiens

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot P45983 1341
xref: PTHR24055:SF222
organism: Homo sapiens

Breast cancer anti-estrogen resistance protein 1
type: ProteinReference
xref: uniprot Q63767 173
xref: PTHR10654:SF15
organism: Rattus norvegicus

Src
type: Protein
entity reference: Src
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P45984 1342
organism: Homo sapiens

Adapter molecule crk
type: ProteinReference
xref: PTHR19969:SF8
xref: uniprot Q63768 845
organism: Rattus norvegicus

uniprot Q6EWH2 1102
type: UnificationXref
id: Q6EWH2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PR50 109
organism: Macaca mulatta

Complex (Fibronectin/Laminin/ Collagen)
type: Complex
component stoichiometry: Fibronectin s10 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: Collagen s12 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: Laminin s11 sa11 STOICHIOMETRY ID COMPLEX
component: Laminin
component: Collagen
component: Fibronectin
feature: COMPLEX BINDING FEATURE s48 a7 1495
feature: COMPLEX BINDING FEATURE s48 a7 1493
feature: COMPLEX BINDING FEATURE s48 a7 1491

uniprot Q99JW4 398
type: UnificationXref
id: Q99JW4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR38537:SF7
xref: uniprot E1BKX7 268
organism: Bos taurus

Talin
type: ProteinReference
xref: P00943
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Talin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Talin Synonym: Synonym not specified Accession: P00943
member entity reference: Talin-1
member entity reference: Talin 1
member entity reference: Uncharacterized protein
member entity reference: RCG55135, isoform CRA_b
member entity reference: Rhea, isoform B

PTHR10574:SF406
type: RelationshipXref
id: PTHR10574:SF406
db: PANTHER Family
relationship type: By Homology

Collagen alpha-1(XII) chain
type: ProteinReference
xref: uniprot Q60847 559
xref: PTHR24020:SF17
organism: Mus musculus

PTHR10574:SF409
type: RelationshipXref
id: PTHR10574:SF409
db: PANTHER Family
relationship type: By Homology

Ras-related protein Rap-1b
type: ProteinReference
xref: PTHR24070:SF393
xref: uniprot F7B9T3 44
organism: Macaca mulatta

ncbitaxon 8364 39
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot F7H998 218
type: UnificationXref
id: F7H998
db: uniprot

PTHR10574:SF405
type: RelationshipXref
id: PTHR10574:SF405
db: PANTHER Family
relationship type: By Homology

uniprot K7CD41 273
type: UnificationXref
id: K7CD41
db: uniprot

FAK
type: Protein
entity reference: FAK
feature: Y925 FAK s66 sa72 rs2
feature: FAK s66 sa72 rs4
feature: COMPLEX PARTICIPANT BINDING FEATURE s66 sa72 1458
feature: FAK s66 sa72 rs3
feature: Y397 FAK s66 sa72 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q92730 1303
type: UnificationXref
id: Q92730
db: uniprot

uniprot A0A0G2K1E2 996
type: UnificationXref
id: A0A0G2K1E2
db: uniprot

Integrin beta s29 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Integrin beta
stoichiometric coefficient: 2.0

PTHR10574:SF400
type: RelationshipXref
id: PTHR10574:SF400
db: PANTHER Family
relationship type: By Homology

Integrin beta-1
type: ProteinReference
xref: uniprot P53712 800
xref: PTHR10082:SF28
organism: Bos taurus

Integrin alpha-2 (Fragment)
type: ProteinReference
xref: PTHR23220:SF23
xref: uniprot P53710 1068
organism: Bos taurus

uniprot P26006 1063
type: UnificationXref
id: P26006
db: uniprot

uniprot A0A3Q1MT97 413
type: UnificationXref
id: A0A3Q1MT97
db: uniprot

Src
type: ProteinReference
xref: P00940
standard name: Src tyrosine kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: Src Synonym: Synonym not specified Accession: P00940
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Src
member entity reference: Tyrosine-protein kinase
member entity reference: Tyrosine-protein kinase Src42A
member entity reference: Tyrosine protein-kinase src-1
member entity reference: Tyrosine-protein kinase FRK
member entity reference: Tyrosine-protein kinase Src64B
member entity reference: Proto-oncogene tyrosine-protein kinase Src
member entity reference: Neuronal proto-oncogene tyrosine-protein kinase Src

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: PTHR12644:SF2
xref: uniprot H2QXW1 222
organism: Pan troglodytes

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot A0A1D5PXS9 255
xref: PTHR24418:SF407
organism: Gallus gallus

Actinin alpha 1
type: ProteinReference
xref: PTHR11915:SF434
xref: uniprot A0A2I3TJQ1 709
organism: Pan troglodytes

uniprot A0A2I3SCY3 1159
type: UnificationXref
id: A0A2I3SCY3
db: uniprot

GTPase HRas
type: ProteinReference
xref: uniprot Q61411 330
xref: PTHR24070:SF385
organism: Mus musculus

Integrin beta s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Integrin beta
stoichiometric coefficient: 2.0

Complex (Integrin beta/Integrin _alpha/ Caveolin/Integrin _alpha/ Integrin beta/Collagen/ Laminin/Fibronectin)
type: Complex
component stoichiometry: Laminin s56 sa62 STOICHIOMETRY ID COMPLEX
component stoichiometry: Fibronectin s57 sa63 STOICHIOMETRY ID COMPLEX
component stoichiometry: Fyn s377 a445 STOICHIOMETRY ID COMPLEX
component stoichiometry: Caveolin s47 sa58 STOICHIOMETRY ID COMPLEX
component stoichiometry: Integrin alpha s46 sa57 STOICHIOMETRY ID COMPLEX
component stoichiometry: Collagen s55 sa61 STOICHIOMETRY ID COMPLEX
component stoichiometry: Integrin beta s45 sa56 STOICHIOMETRY ID COMPLEX
component: Caveolin
component: Integrin beta
component: Fibronectin
component: Fyn
component: Integrin alpha
component: Collagen
component: Laminin
feature: COMPLEX BINDING FEATURE s303 a444 1399
feature: COMPLEX BINDING FEATURE s303 a444 1397
feature: COMPLEX BINDING FEATURE s303 a444 1391
feature: COMPLEX BINDING FEATURE s303 a444 1393
feature: COMPLEX BINDING FEATURE s303 a444 1389
feature: COMPLEX BINDING FEATURE s303 a444 1401
feature: COMPLEX BINDING FEATURE s303 a444 1395
cellular location: cytoplasm

uniprot F6XT65 114
type: UnificationXref
id: F6XT65
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GLS1 1029
xref: PTHR23220:SF22
organism: Macaca mulatta

Phosphoinositide-3-kinase regulatory subunit 2
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot H2QFS6 910
organism: Pan troglodytes

uniprot O42825 1272
type: UnificationXref
id: O42825
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r91
controller: Raf

PTHR19969:SF8
type: RelationshipXref
id: PTHR19969:SF8
db: PANTHER Family
relationship type: By Homology

uniprot Q61194 939
type: UnificationXref
id: Q61194
db: uniprot

Collagen alpha-1(II) chain
type: ProteinReference
xref: PTHR24023:SF58
xref: uniprot P05539 509
organism: Rattus norvegicus

RAP2C, member of RAS oncogene family
type: ProteinReference
xref: PTHR24070:SF200
xref: uniprot D3ZK56 19
organism: Rattus norvegicus

uniprot P61224 63
type: UnificationXref
id: P61224
db: uniprot

uniprot F6PNX7 598
type: UnificationXref
id: F6PNX7
db: uniprot

PTHR10048:SF7
type: RelationshipXref
id: PTHR10048:SF7
db: PANTHER Family
relationship type: By Homology

uniprot A0A3Q1N9E9 1184
type: UnificationXref
id: A0A3Q1N9E9
db: uniprot

uniprot P39688 1099
type: UnificationXref
id: P39688
db: uniprot

uniprot Q13418 857
type: UnificationXref
id: Q13418
db: uniprot

Y925 FAK s134 a146 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y925
feature location: Y925 FAK s134 a146 rs2 Y925
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.58380694263043
comment: MODIFICATION_RESIDUE_NAME=Y925

Actin s44 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Actin
stoichiometric coefficient: 1.0

uniprot P70600 829
type: UnificationXref
id: P70600
db: uniprot

uniprot Q5TAT6 558
type: UnificationXref
id: Q5TAT6
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot P10398 638
organism: Homo sapiens

uniprot Q5E963 240
type: UnificationXref
id: Q5E963
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot A0A2I3SIH9 980
organism: Pan troglodytes

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot O88763 922
xref: PTHR10048:SF7
organism: Rattus norvegicus

Integrin beta
type: Protein
entity reference: Integrin beta
feature: ACTIVE 89
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 1358
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Integrin subunit beta like 1
type: ProteinReference
xref: uniprot E2QY83 764
xref: PTHR10082:SF3
organism: Canis lupus familiaris

Integrin alpha-M
type: ProteinReference
xref: uniprot P05555 1049
xref: PTHR23220:SF130
organism: Mus musculus

Integrin beta-1
type: ProteinReference
xref: PTHR10082:SF28
xref: uniprot P05556 787
organism: Homo sapiens

uniprot P22543 923
type: UnificationXref
id: P22543
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LWV5 669
xref: PTHR12552:SF4
organism: Bos taurus

uniprot P05094 729
type: UnificationXref
id: P05094
db: uniprot

STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_r99
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r99 1571
participant stoichiometry: PARTICIPANT STOICHIOMETRY r99 1570
left: Rho
interaction type: STATE_TRANSITION
right: Rho

uniprot F7FR08 1267
type: UnificationXref
id: F7FR08
db: uniprot

Integrin beta
type: ProteinReference
xref: uniprot F6X717 774
xref: PTHR10082:SF9
organism: Canis lupus familiaris

uniprot F6USY2 112
type: UnificationXref
id: F6USY2
db: uniprot

uniprot F7A567 964
type: UnificationXref
id: F7A567
db: uniprot

Collagen type IV alpha 5 chain
type: ProteinReference
xref: PTHR24023:SF877
xref: uniprot A0A3Q1M970 411
organism: Bos taurus

uniprot O70173 921
type: UnificationXref
id: O70173
db: uniprot

uniprot A0A2J8QVK7 1181
type: UnificationXref
id: A0A2J8QVK7
db: uniprot

COL13A1 isoform 3
type: ProteinReference
xref: PTHR24023:SF871
xref: uniprot H2R296 485
organism: Pan troglodytes

Collagen alpha-1(VIII) chain
type: ProteinReference
xref: uniprot P27658 534
xref: PTHR24023:SF903
organism: Homo sapiens

uniprot F7C2W0 854
type: UnificationXref
id: F7C2W0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q3ACS4 872
xref: PTHR10155:SF3
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: PTHR23220:SF21
xref: uniprot F6XG33 1025
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR24023:SF912
xref: uniprot F6PP96 445
organism: Macaca mulatta

uniprot A0A3Q2TY19 1330
type: UnificationXref
id: A0A3Q2TY19
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot Q7ZUQ0 243
organism: Danio rerio

Actin-related protein 2/3 complex subunit 1A
type: ProteinReference
xref: uniprot Q92747 245
xref: PTHR10709:SF11
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6QWB7 1124
xref: PTHR11937:SF477
organism: Ornithorhynchus anatinus

uniprot F7BJV7 461
type: UnificationXref
id: F7BJV7
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63085 142
organism: Mus musculus

uniprot D3ZW82 1010
type: UnificationXref
id: D3ZW82
db: uniprot

ADP-ribosylation factor A1F
type: ProteinReference
xref: PTHR11711:SF340
xref: uniprot Q6ID97 617
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63086 143
xref: PTHR24055:SF203
organism: Rattus norvegicus

Fibronectin
type: Protein
entity reference: Fibronectin
feature: COMPLEX PARTICIPANT BINDING FEATURE s57 sa63 1402
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P49024 1323
type: UnificationXref
id: P49024
db: uniprot

uniprot Q9UMD9 578
type: UnificationXref
id: Q9UMD9
db: uniprot

Paxillin
type: Protein
entity reference: Paxillin
feature: Paxillin s65 sa71 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s65 sa71 1456
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Dedicator of cytokinesis protein 1
type: ProteinReference
xref: uniprot Q14185 753
organism: Homo sapiens

Laminin subunit beta 1
type: ProteinReference
xref: PTHR10574:SF233
xref: uniprot D3ZQN7 1187
organism: Rattus norvegicus

Tyrosine-protein kinase CSK
type: ProteinReference
xref: uniprot P41240 262
xref: PTHR24418:SF407
organism: Homo sapiens

Tyrosine-protein kinase CSK
type: ProteinReference
xref: uniprot P41241 263
xref: PTHR24418:SF407
organism: Mus musculus

Collagen alpha-2(IV) chain
type: ProteinReference
xref: PTHR24023:SF989
xref: uniprot P17140 527
organism: Caenorhabditis elegans

STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r90
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 1598
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 1599
left: Raf
interaction type: STATE_TRANSITION
right: Raf

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EJH1 974
xref: PTHR19143:SF267
organism: Macaca mulatta

uniprot Q12526 324
type: UnificationXref
id: Q12526
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot P53779 141
organism: Homo sapiens

Rho-related GTP-binding protein Rho6
type: ProteinReference
xref: PTHR24072:SF23
xref: uniprot Q92730 1303
organism: Homo sapiens

Integrin beta
type: ProteinReference
xref: uniprot B2RYB8 763
xref: PTHR10082:SF15
organism: Rattus norvegicus

Integrin alpha 3 variant B
type: ProteinReference
xref: PTHR23220:SF89
xref: uniprot D3ZQM3 1009
organism: Rattus norvegicus

uniprot F1A4I5 27
type: UnificationXref
id: F1A4I5
db: uniprot

uniprot F7BDD8 1204
type: UnificationXref
id: F7BDD8
db: uniprot

uniprot E1BIM8 982
type: UnificationXref
id: E1BIM8
db: uniprot

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot F1MSX4 104
organism: Bos taurus

Rac family small GTPase 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q6GL60 701
organism: Xenopus tropicalis

STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r92
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r92 1595
participant stoichiometry: PARTICIPANT STOICHIOMETRY r92 1594
left: ERK
interaction type: STATE_TRANSITION
right: ERK

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q02750 145
xref: PTHR48013:SF5
organism: Homo sapiens

ncbitaxon 6239 182
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot F7CW18 825
type: UnificationXref
id: F7CW18
db: uniprot

uniprot Q62848 184
type: UnificationXref
id: Q62848
db: uniprot

Son of sevenless homolog 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot Q62245 385
organism: Mus musculus

ARHGAP10 isoform 3
type: ProteinReference
xref: PTHR12552:SF5
xref: uniprot K7C248 677
organism: Pan troglodytes

V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
type: ProteinReference
xref: uniprot A0A2R8Q8S1 284
xref: PTHR24070:SF388
organism: Danio rerio

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: PTHR10709:SF10
xref: uniprot Q9WV32 254
organism: Mus musculus

uniprot O77086 747
type: UnificationXref
id: O77086
db: uniprot

uniprot F6ZCA5 455
type: UnificationXref
id: F6ZCA5
db: uniprot

uniprot D3ZCV0 713
type: UnificationXref
id: D3ZCV0
db: uniprot

uniprot A0A2I3SBV7 745
type: UnificationXref
id: A0A2I3SBV7
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LWJ8 1329
xref: PTHR24055:SF222
organism: Bos taurus

uniprot Q5U2U2 844
type: UnificationXref
id: Q5U2U2
db: uniprot

uniprot A0A1D5Q585 1177
type: UnificationXref
id: A0A1D5Q585
db: uniprot

uniprot Q66JE6 158
type: UnificationXref
id: Q66JE6
db: uniprot

uniprot H2Q7Q7 51
type: UnificationXref
id: H2Q7Q7
db: uniprot

uniprot O88656 230
type: UnificationXref
id: O88656
db: uniprot

uniprot Q14050 554
type: UnificationXref
id: Q14050
db: uniprot

uniprot H2Q0R2 1208
type: UnificationXref
id: H2Q0R2
db: uniprot

uniprot Q9VMV5 579
type: UnificationXref
id: Q9VMV5
db: uniprot

Filamin-A isoform 2
type: ProteinReference
xref: uniprot F7GCM2 272
xref: PTHR38537:SF5
organism: Macaca mulatta

uniprot P62330 365
type: UnificationXref
id: P62330
db: uniprot

uniprot P20849 529
type: UnificationXref
id: P20849
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__p130CAS-_C3G-_Crk-RIGHT__Complex__Crk_C3G__p130CAS_-_r20
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 1629
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 1630
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 1632
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 1631
left: Crk
left: C3G
left: p130CAS
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Crk/C3G/ p130CAS)

Col4a5 protein
type: ProteinReference
xref: PTHR24023:SF877
xref: uniprot Q63ZW6 561
organism: Mus musculus

uniprot F1LQ00 431
type: UnificationXref
id: F1LQ00
db: uniprot

Arp2/3 complex 34 kDa subunit
type: ProteinReference
xref: uniprot Q6GL82 242
xref: PTHR12058:SF0
organism: Xenopus tropicalis

GTPase HRas isoform 1
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot F7F5K9 300
organism: Macaca mulatta

uniprot Q8BH27 1242
type: UnificationXref
id: Q8BH27
db: uniprot

uniprot Q66H76 1325
type: UnificationXref
id: Q66H76
db: uniprot

uniprot Q7QIG1 1083
type: UnificationXref
id: Q7QIG1
db: uniprot

uniprot P25940 533
type: UnificationXref
id: P25940
db: uniprot

Tyrosine-protein kinase CSK
type: ProteinReference
xref: uniprot Q0VBZ0 264
xref: PTHR24418:SF407
organism: Bos taurus

Protein CBR-LET-2
type: ProteinReference
xref: PTHR24023:SF989
xref: uniprot A8XNK9 418
organism: Caenorhabditis briggsae

uniprot Q9QUI0 1310
type: UnificationXref
id: Q9QUI0
db: uniprot

uniprot P31938 138
type: UnificationXref
id: P31938
db: uniprot

PIP2
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s58 sa67 1408
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Arf6
type: ProteinReference
xref: P00919
standard name: ADP ribosylation factor 6
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Arf6
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: ADP ribosylation factor 6 Synonym: ARF6,Adenosine diphosphate ribosylation factor 6 Accession: P00919
member entity reference: ADP-ribosylation factor 6
member entity reference: ADP ribosylation factor 6
member entity reference: Uncharacterized protein
member entity reference: ADP-ribosylation factor 6a
member entity reference: Predicted protein

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A567 964
xref: PTHR24072:SF136
organism: Monodelphis domestica

uniprot Q09914 1286
type: UnificationXref
id: Q09914
db: uniprot

Cdc42 homolog
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot Q17031 969
organism: Anopheles gambiae

uniprot A0A2I3S4I6 1249
type: UnificationXref
id: A0A2I3S4I6
db: uniprot

Integrin subunit alpha 6
type: ProteinReference
xref: PTHR23220:SF9
xref: uniprot A0A3Q1M8K4 1003
organism: Bos taurus

COL16A1 isoform 1
type: ProteinReference
xref: uniprot K7BGM3 492
xref: PTHR24023:SF372
organism: Pan troglodytes

STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r91
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r91 1596
participant stoichiometry: PARTICIPANT STOICHIOMETRY r91 1597
left: MEK
interaction type: STATE_TRANSITION
right: MEK

uniprot B2GV73 205
type: UnificationXref
id: B2GV73
db: uniprot

uniprot O97182 232
type: UnificationXref
id: O97182
db: uniprot

uniprot Q27591 802
type: UnificationXref
id: Q27591
db: uniprot

Uncharacterized protein rasB
type: ProteinReference
xref: PTHR24070:SF206
xref: uniprot F0ZI47 294
organism: Dictyostelium purpureum

uniprot F7FRN8 855
type: UnificationXref
id: F7FRN8
db: uniprot

uniprot A0A3Q3ACS4 872
type: UnificationXref
id: A0A3Q3ACS4
db: uniprot

uniprot Q94125 951
type: UnificationXref
id: Q94125
db: uniprot

Collagen alpha-1(IV) chain
type: ProteinReference
xref: uniprot P17139 526
xref: PTHR24023:SF1005
organism: Caenorhabditis elegans

uniprot F6YS73 271
type: UnificationXref
id: F6YS73
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F1Q3M8 887
xref: PTHR10048:SF107
organism: Canis lupus familiaris

uniprot O00443 914
type: UnificationXref
id: O00443
db: uniprot

Parvin alpha
type: ProteinReference
xref: PTHR12114:SF6
xref: uniprot K7DA60 1166
organism: Pan troglodytes

uniprot D3ZAC0 1006
type: UnificationXref
id: D3ZAC0
db: uniprot

uniprot H9FVU5 912
type: UnificationXref
id: H9FVU5
db: uniprot

uniprot A0A2I3TI23 408
type: UnificationXref
id: A0A2I3TI23
db: uniprot

uniprot F7A7I3 1130
type: UnificationXref
id: F7A7I3
db: uniprot

ADP ribosylation factor 6
type: ProteinReference
xref: PTHR11711:SF379
xref: uniprot F6URT1 359
organism: Ornithorhynchus anatinus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot H9FVU5 912
xref: PTHR10048:SF107
organism: Macaca mulatta

Integrin subunit alpha 2
type: ProteinReference
xref: PTHR23220:SF23
xref: uniprot A0A2I3T1C0 999
organism: Pan troglodytes

PTHR23113:SF150
type: RelationshipXref
id: PTHR23113:SF150
db: PANTHER Family
relationship type: By Homology

uniprot P79996 1344
type: UnificationXref
id: P79996
db: uniprot

Collagen type VIII alpha 2 chain
type: ProteinReference
xref: uniprot F1MJR6 433
xref: PTHR24023:SF1027
organism: Bos taurus

uniprot Q62159 1295
type: UnificationXref
id: Q62159
db: uniprot

uniprot F6WV79 1335
type: UnificationXref
id: F6WV79
db: uniprot

uniprot A0A0G2K344 862
type: UnificationXref
id: A0A0G2K344
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF2
xref: uniprot O97182 232
organism: Drosophila melanogaster

uniprot F0ZN94 689
type: UnificationXref
id: F0ZN94
db: uniprot

Integrin alpha
type: ProteinReference
xref: P00941
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Integrin_br__alpha
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Integrin alpha-E
member entity reference: Integrin subunit alpha 6
member entity reference: Integrin subunit alpha 5
member entity reference: Integrin alpha-3
member entity reference: Integrin alpha-V
member entity reference: Integrin subunit alpha 4
member entity reference: Integrin subunit alpha 11
member entity reference: Integrin alpha-5
member entity reference: Integrin alpha-6
member entity reference: Integrin alpha-D
member entity reference: Uncharacterized protein
member entity reference: Integrin alpha-PS3
member entity reference: Integrin alpha-PS5
member entity reference: Integrin alpha-7
member entity reference: ITGA4 isoform 3
member entity reference: Integrin, alpha 10
member entity reference: Integrin subunit alpha 3
member entity reference: Integrin subunit alpha 2
member entity reference: Integrin alpha-11
member entity reference: Integrin alpha-2
member entity reference: Integrin alpha-1
member entity reference: Integrin subunit alpha 8
member entity reference: Integrin alpha 3 variant B
member entity reference: Integrin subunit alpha 2b
member entity reference: Integrin alpha-X
member entity reference: ITGA8 isoform 1
member entity reference: Integrin alpha-L
member entity reference: Integrin alpha 5 (Mapped)
member entity reference: Integrin subunit alpha 9
member entity reference: ITGA9 isoform 2
member entity reference: AGAP004303-PA
member entity reference: Integrin alpha-IIb
member entity reference: Integrin alpha-9
member entity reference: ITGAV isoform 1
member entity reference: AGAP006826-PA
member entity reference: Integrin alpha-PS2
member entity reference: Integrin subunit alpha 10
member entity reference: Integrin alpha-10
member entity reference: Integrin subunit alpha 1
member entity reference: ITGA6 isoform 6
member entity reference: Integrin alpha-8
member entity reference: Integrin alpha-4
member entity reference: Integrin alpha-2 (Fragment)
member entity reference: Integrin subunit alpha 7
member entity reference: ITGA1 isoform 1

Integrin beta s13 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Integrin beta
stoichiometric coefficient: 1.0

PTHR48013:SF8
type: RelationshipXref
id: PTHR48013:SF8
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: uniprot O35099 133
organism: Mus musculus

Inactive tyrosine-protein kinase kin-32
type: ProteinReference
xref: uniprot Q95YD4 833
organism: Caenorhabditis elegans

Collagen alpha-2(VI) chain
type: ProteinReference
xref: uniprot Q02788 545
xref: PTHR24020:SF29
organism: Mus musculus

uniprot B8JHU4 712
type: UnificationXref
id: B8JHU4
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F6Y841 895
organism: Canis lupus familiaris

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 325

Uncharacterized protein rapA
type: ProteinReference
xref: PTHR24070:SF263
xref: uniprot F1A4I5 27
organism: Dictyostelium purpureum

PTHR48013:SF5
type: RelationshipXref
id: PTHR48013:SF5
db: PANTHER Family
relationship type: By Homology

uniprot Q63ZW6 561
type: UnificationXref
id: Q63ZW6
db: uniprot

Integrin subunit alpha 8
type: ProteinReference
xref: uniprot B5DEG1 420
xref: PTHR23220:SF5
organism: Rattus norvegicus

Protein tyrosine kinase 2
type: ProteinReference
xref: PTHR46221:SF5
xref: uniprot F6WLE6 823
organism: Monodelphis domestica

uniprot Q04857 547
type: UnificationXref
id: Q04857
db: uniprot

Ras
type: ProteinReference
xref: P00916
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Ras Synonym: Synonym not specified Accession: P00916
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Ras
member entity reference: Predicted protein
member entity reference: GTPase HRas
member entity reference: Ras-like protein rasB
member entity reference: GTPase NRas
member entity reference: Ras-related protein R-Ras
member entity reference: RAS related
member entity reference: Harvey rat sarcoma viral oncogene homolog
member entity reference: Ras-like protein rasG
member entity reference: Ras protein let-60
member entity reference: GTPase HRas isoform 1
member entity reference: NRAS isoform 1
member entity reference: Ras-like protein 1
member entity reference: Uncharacterized protein
member entity reference: Related RAS viral (R-ras) oncogene homolog
member entity reference: Uncharacterized protein rasG
member entity reference: -Ha-ras Harvey rat sarcoma viral oncogene homolog, like
member entity reference: Uncharacterized protein rasB
member entity reference: GTPase KRas
member entity reference: Ras-like protein
member entity reference: HRAS isoform 2
member entity reference: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
member entity reference: Protein ras-1
member entity reference: Protein CBR-LET-60
member entity reference: HRas proto-oncogene, GTPase a
member entity reference: Ras-like protein 2
member entity reference: NRAS protein
member entity reference: NRAS proto-oncogene, GTPase

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF362
xref: uniprot Q7ZVI7 1157
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TD14 891
xref: PTHR10155:SF3
organism: Monodelphis domestica

Tyrosine-protein phosphatase non-receptor type 12
type: ProteinReference
xref: PTHR45983:SF3
xref: uniprot F1PZ23 278
organism: Canis lupus familiaris

uniprot H2QKI4 342
type: UnificationXref
id: H2QKI4
db: uniprot

Paxillin s23 sa23 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Laminin subunit alpha-1
type: ProteinReference
xref: PTHR10574:SF409
xref: uniprot P25391 1224
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r35 1569
type: Stoichiometry
physical entity: Complex (Paxillin/PTP-PEST)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r35 1568
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r35 1567
type: Stoichiometry
physical entity: PTP-PEST
stoichiometric coefficient: 1.0

uniprot P85970 233
type: UnificationXref
id: P85970
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6SW23 889
xref: PTHR10048:SF107
organism: Gallus gallus

uniprot B1N4V4 12
type: UnificationXref
id: B1N4V4
db: uniprot

eco ECO:0000250 5
type: UnificationXref
id: ECO:0000250
db: eco

uniprot F1P859 372
type: UnificationXref
id: F1P859
db: uniprot

uniprot H2QJ46 477
type: UnificationXref
id: H2QJ46
db: uniprot

uniprot Q07563 552
type: UnificationXref
id: Q07563
db: uniprot

uniprot P00528 989
type: UnificationXref
id: P00528
db: uniprot

uniprot O00909 603
type: UnificationXref
id: O00909
db: uniprot

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot Q9Y6R4 167
organism: Homo sapiens

Src
type: Protein
entity reference: Src
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ELMO
type: Protein
entity reference: ELMO
feature: COMPLEX PARTICIPANT BINDING FEATURE s81 sa93 1388
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q9Z0T9 814
type: UnificationXref
id: Q9Z0T9
db: uniprot

Collagen alpha-1(XVII) chain
type: ProteinReference
xref: uniprot Q9UMD9 578
xref: PTHR24023:SF891
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r99 1571
type: Stoichiometry
physical entity: Rho
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r99 1570
type: Stoichiometry
physical entity: Rho
stoichiometric coefficient: 1.0

uniprot Q6LC82 702
type: UnificationXref
id: Q6LC82
db: uniprot

Integrin beta
type: ProteinReference
xref: PTHR10082:SF28
xref: uniprot K7E435 782
organism: Monodelphis domestica

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q7ZVK8 160
xref: PTHR24055:SF393
organism: Danio rerio

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 308

uniprot Q7ZVK8 160
type: UnificationXref
id: Q7ZVK8
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F6URW3 375
organism: Ornithorhynchus anatinus

uniprot P40616 606
type: UnificationXref
id: P40616
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 56

Integrin alpha-6
type: ProteinReference
xref: PTHR23220:SF9
xref: uniprot P23229 1061
organism: Homo sapiens

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot F7H998 218
xref: PTHR12391:SF1
organism: Macaca mulatta

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot F7DXH6 985
organism: Xenopus tropicalis

Vasodilator-stimulated phosphoprotein
type: ProteinReference
xref: PTHR11202:SF12
xref: uniprot P70460 851
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5NYG3 266
xref: PTHR38537:SF7
organism: Gallus gallus

uniprot J9NUT8 1045
type: UnificationXref
id: J9NUT8
db: uniprot

uniprot Q9HB97 1170
type: UnificationXref
id: Q9HB97
db: uniprot

Collagen type VI alpha 2 chain
type: ProteinReference
xref: uniprot F1LNH3 430
xref: PTHR24020:SF29
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EU36 1133
xref: PTHR11937:SF414
organism: Monodelphis domestica

uniprot P34149 695
type: UnificationXref
id: P34149
db: uniprot

uniprot Q5R1X3 1153
type: UnificationXref
id: Q5R1X3
db: uniprot

uniprot F7DTH8 722
type: UnificationXref
id: F7DTH8
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A0A1D5PXC6 1328
organism: Gallus gallus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF341
xref: uniprot A8X1S0 1332
organism: Caenorhabditis briggsae

Actin
type: Protein
entity reference: Actin
feature: COMPLEX PARTICIPANT BINDING FEATURE s44 sa44 1500
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P02469 1217
type: UnificationXref
id: P02469
db: uniprot

DNAJC27 isoform 2
type: ProteinReference
xref: uniprot H2QHJ6 52
organism: Pan troglodytes

uniprot F6RYV4 1262
type: UnificationXref
id: F6RYV4
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot Q6P023 159
organism: Danio rerio

uniprot D4A3T0 369
type: UnificationXref
id: D4A3T0
db: uniprot

uniprot Q9P218 574
type: UnificationXref
id: Q9P218
db: uniprot

uniprot Q503B6 328
type: UnificationXref
id: Q503B6
db: uniprot

uniprot P43406 1067
type: UnificationXref
id: P43406
db: uniprot

uniprot Q8SQB8 811
type: UnificationXref
id: Q8SQB8
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1P630 1333
xref: PTHR24055:SF172
organism: Canis lupus familiaris

Crk s24 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Crk
stoichiometric coefficient: 1.0

ADP-ribosylation factor GTPase-activating protein 1
type: ProteinReference
xref: uniprot Q8N6T3 185
organism: Homo sapiens

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 39

Integrin alpha-L
type: ProteinReference
xref: PTHR23220:SF84
xref: uniprot P20701 1059
organism: Homo sapiens

Integrin alpha-X
type: ProteinReference
xref: uniprot P20702 1060
xref: PTHR23220:SF118
organism: Homo sapiens

Collagen type IX alpha 1 chain
type: ProteinReference
xref: PTHR24023:SF918
xref: uniprot F1PPQ7 442
organism: Canis lupus familiaris

uniprot F6WLE6 823
type: UnificationXref
id: F6WLE6
db: uniprot

PTHR10574:SF398
type: RelationshipXref
id: PTHR10574:SF398
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2R0G7 1340
xref: PTHR24055:SF222
organism: Pan troglodytes

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: uniprot Q62159 1295
xref: PTHR24072:SF100
organism: Mus musculus

uniprot G3V852 1109
type: UnificationXref
id: G3V852
db: uniprot

uniprot Q28247 556
type: UnificationXref
id: Q28247
db: uniprot

Filamin-B
type: ProteinReference
xref: uniprot Q80X90 276
xref: PTHR38537:SF7
organism: Mus musculus

uniprot P62746 1283
type: UnificationXref
id: P62746
db: uniprot

uniprot C0KUC6 388
type: UnificationXref
id: C0KUC6
db: uniprot

Raf
type: Protein
entity reference: Raf
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZXR6 457
xref: PTHR24020:SF18
organism: Macaca mulatta

uniprot A8Y1X2 981
type: UnificationXref
id: A8Y1X2
db: uniprot

Proto-oncogene tyrosine-protein kinase Src
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot Q9WUD9 995
organism: Rattus norvegicus

Alpha-actinin-2
type: ProteinReference
xref: uniprot P35609 733
xref: PTHR11915:SF429
organism: Homo sapiens

Talin s30 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Talin
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6TKL3 1334
xref: PTHR24055:SF222
organism: Xenopus tropicalis

uniprot P18613 60
type: UnificationXref
id: P18613
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1M7B6 1161
xref: PTHR12114:SF7
organism: Bos taurus

ADP ribosylation factor 6
type: ProteinReference
xref: uniprot E2RHL4 356
xref: PTHR11711:SF379
organism: Canis lupus familiaris

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF362
xref: uniprot Q7ZVF9 1156
organism: Danio rerio

PI3K
type: Protein
entity reference: PI3K
feature: ACTIVE 89
feature: PI3K s211 a299 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F6XF95 1024
type: UnificationXref
id: F6XF95
db: uniprot

uniprot E2RH85 880
type: UnificationXref
id: E2RH85
db: uniprot

Collagen alpha-1(XXVII) chain
type: ProteinReference
xref: PTHR24023:SF844
xref: uniprot Q8IZC6 569
organism: Homo sapiens

PTHR10574:SF79
type: RelationshipXref
id: PTHR10574:SF79
db: PANTHER Family
relationship type: By Homology

uniprot R4GI31 1312
type: UnificationXref
id: R4GI31
db: uniprot

Complex (Csk/Paxillin)
type: Complex
component stoichiometry: Paxillin s22 sa22 STOICHIOMETRY ID COMPLEX
component stoichiometry: Csk s21 sa21 STOICHIOMETRY ID COMPLEX
component: Paxillin
component: Csk
feature: COMPLEX BINDING FEATURE s214 a309 1405
feature: COMPLEX BINDING FEATURE s214 a309 1403
cellular location: cytoplasm

Integrin beta-6
type: ProteinReference
xref: PTHR10082:SF11
xref: uniprot Q9Z0T9 814
organism: Mus musculus

uniprot F7B727 1321
type: UnificationXref
id: F7B727
db: uniprot

uniprot A7S0V7 1115
type: UnificationXref
id: A7S0V7
db: uniprot

PTHR11915:SF434
type: RelationshipXref
id: PTHR11915:SF434
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1N3A0 1183
xref: PTHR10574:SF291
organism: Bos taurus

uniprot F6VDT1 674
type: UnificationXref
id: F6VDT1
db: uniprot

PTHR11915:SF432
type: RelationshipXref
id: PTHR11915:SF432
db: PANTHER Family
relationship type: By Homology

uniprot Q9HB63 1244
type: UnificationXref
id: Q9HB63
db: uniprot

uniprot P97927 1226
type: UnificationXref
id: P97927
db: uniprot

PTHR11915:SF429
type: RelationshipXref
id: PTHR11915:SF429
db: PANTHER Family
relationship type: By Homology

PTHR48013:SF15
type: RelationshipXref
id: PTHR48013:SF15
db: PANTHER Family
relationship type: By Homology

uniprot H2Q2J4 475
type: UnificationXref
id: H2Q2J4
db: uniprot

uniprot Q9QZS0 576
type: UnificationXref
id: Q9QZS0
db: uniprot

uniprot Q62470 1080
type: UnificationXref
id: Q62470
db: uniprot

uniprot P60952 967
type: UnificationXref
id: P60952
db: uniprot

uniprot F1MMS9 1018
type: UnificationXref
id: F1MMS9
db: uniprot

uniprot F6TKL3 1334
type: UnificationXref
id: F6TKL3
db: uniprot

uniprot F7GH95 50
type: UnificationXref
id: F7GH95
db: uniprot

PTHR11915:SF425
type: RelationshipXref
id: PTHR11915:SF425
db: PANTHER Family
relationship type: By Homology

Paxillin
type: Protein
entity reference: Paxillin
feature: Paxillin s209 a296 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot E1BA17 426
type: UnificationXref
id: E1BA17
db: uniprot

uniprot F6Z5U1 454
type: UnificationXref
id: F6Z5U1
db: uniprot

uniprot Q6IQP4 80
type: UnificationXref
id: Q6IQP4
db: uniprot

uniprot F1QNG4 297
type: UnificationXref
id: F1QNG4
db: uniprot

PTHR48013:SF21
type: RelationshipXref
id: PTHR48013:SF21
db: PANTHER Family
relationship type: By Homology

PTHR48013:SF20
type: RelationshipXref
id: PTHR48013:SF20
db: PANTHER Family
relationship type: By Homology

uniprot Q640R7 77
type: UnificationXref
id: Q640R7
db: uniprot

Integrin beta-nu
type: ProteinReference
xref: uniprot Q27591 802
xref: PTHR10082:SF59
organism: Drosophila melanogaster

uniprot P21708 134
type: UnificationXref
id: P21708
db: uniprot

uniprot E2R5H4 853
type: UnificationXref
id: E2R5H4
db: uniprot

Integrin beta
type: ProteinReference
xref: PTHR10082:SF36
xref: uniprot G3V7M2 778
organism: Rattus norvegicus

uniprot A7S615 355
type: UnificationXref
id: A7S615
db: uniprot

Laminin subunit gamma-1
type: ProteinReference
xref: uniprot P15215 1221
xref: PTHR10574:SF79
organism: Drosophila melanogaster

COL4A1 isoform 1
type: ProteinReference
xref: PTHR24023:SF854
xref: uniprot K7C8P4 493
organism: Pan troglodytes

Paxillin s209 a296 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 590

Fibronectin s9 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fibronectin
stoichiometric coefficient: 1.0

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F7GJZ7 258
xref: PTHR24418:SF407
organism: Monodelphis domestica

Rap1
type: ProteinReference
xref: P00906
standard name: Ras associated protein 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Rap1
comment: ENTITY_REFERENCE_NOTES=Long Name: Rap1 Synonym: Synonym not specified Accession: P00906
member entity reference: RAP2A isoform 1
member entity reference: Ras-related protein Rap-2c
member entity reference: Ras family GTPase
member entity reference: Ras-related protein Rap-1b
member entity reference: RAP2C, member of RAS oncogene family
member entity reference: Ras-related protein Rap-2b
member entity reference: Uncharacterized protein
member entity reference: Ras-related protein Rap-1A
member entity reference: RE63021p
member entity reference: RAP2A, member of RAS oncogene family
member entity reference: RAP2A, member of RAS oncogene family a
member entity reference: DnaJ homolog subfamily C member 27
member entity reference: RAP2A, member of RAS oncogene family b
member entity reference: Ras-related protein rapA
member entity reference: Ras-related protein Rap-2a
member entity reference: RAP2B, member of RAS oncogene family
member entity reference: RAP1A, member of RAS oncogene family
member entity reference: Uncharacterized protein rapA
member entity reference: AGAP001874-PA
member entity reference: DNAJC27 isoform 2
member entity reference: DnaJ homolog subfamily C member 27 isoform 1
member entity reference: RAP1A isoform 1
member entity reference: Ras-like protein 3, putative
member entity reference: RAP2B isoform 1
member entity reference: Ras-related protein Rap1
member entity reference: RAP1B, member of RAS oncogene family
member entity reference: RAP2B protein

uniprot O15145 227
type: UnificationXref
id: O15145
db: uniprot

uniprot H2QEC7 1209
type: UnificationXref
id: H2QEC7
db: uniprot

VASP s92 sa101 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: VASP
stoichiometric coefficient: 1.0

uniprot A0A1D5Q4K0 402
type: UnificationXref
id: A0A1D5Q4K0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot F6QM53 888
organism: Ornithorhynchus anatinus

Predicted protein
type: ProteinReference
xref: uniprot A7STP5 286
xref: PTHR24070:SF420
organism: Nematostella vectensis

uniprot F7DM33 339
type: UnificationXref
id: F7DM33
db: uniprot

PARTICIPANT STOICHIOMETRY r89 1615
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

uniprot P47809 666
type: UnificationXref
id: P47809
db: uniprot

PARTICIPANT STOICHIOMETRY r89 1616
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

Putative actin-22
type: ProteinReference
xref: PTHR11937:SF421
xref: uniprot Q553U6 1149
organism: Dictyostelium discoideum

uniprot P15215 1221
type: UnificationXref
id: P15215
db: uniprot

uniprot Q3MHR7 235
type: UnificationXref
id: Q3MHR7
db: uniprot

uniprot P40793 965
type: UnificationXref
id: P40793
db: uniprot

Collagen alpha-1(VI) chain
type: ProteinReference
xref: PTHR24023:SF917
xref: uniprot P20785 528
organism: Gallus gallus

uniprot F1PXS7 108
type: UnificationXref
id: F1PXS7
db: uniprot

uniprot P11584 790
type: UnificationXref
id: P11584
db: uniprot

uniprot A0A2I3SIH9 980
type: UnificationXref
id: A0A2I3SIH9
db: uniprot

Ras homolog family member B
type: ProteinReference
xref: uniprot Q6NVL3 1299
xref: PTHR24072:SF0
organism: Xenopus tropicalis

uniprot F1PS24 443
type: UnificationXref
id: F1PS24
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Z8M9 600
xref: PTHR11711:SF357
organism: Monodelphis domestica

uniprot Q7PME7 809
type: UnificationXref
id: Q7PME7
db: uniprot

Collagen alpha-1(XIV) chain
type: ProteinReference
xref: uniprot Q80X19 567
xref: PTHR24020:SF15
organism: Mus musculus

uniprot Q9Y3L5 88
type: UnificationXref
id: Q9Y3L5
db: uniprot

uniprot Q8BFZ3 1158
type: UnificationXref
id: Q8BFZ3
db: uniprot

Ras-like protein
type: ProteinReference
xref: PTHR24070:SF17
xref: uniprot P0CQ42 313
organism: Cryptococcus neoformans

uniprot P26675 381
type: UnificationXref
id: P26675
db: uniprot

Rac family small GTPase 1a
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q7ZSZ9 704
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F7F5X1 301
organism: Monodelphis domestica

uniprot H2QUU0 281
type: UnificationXref
id: H2QUU0
db: uniprot

uniprot A0A2I3T5X3 3
type: UnificationXref
id: A0A2I3T5X3
db: uniprot

uniprot Q9JI04 572
type: UnificationXref
id: Q9JI04
db: uniprot

uniprot P08122 513
type: UnificationXref
id: P08122
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot W4ZCX2 581
organism: Strongylocentrotus purpuratus

uniprot F1PHV7 296
type: UnificationXref
id: F1PHV7
db: uniprot

Rho-related GTP-binding protein RhoN
type: ProteinReference
xref: PTHR24072:SF21
xref: uniprot P52198 1277
organism: Homo sapiens

RCG55135, isoform CRA_b
type: ProteinReference
xref: PTHR19981:SF7
xref: uniprot G3V852 1109
organism: Rattus norvegicus

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s85 sa65 1354
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR12771:SF8
type: RelationshipXref
id: PTHR12771:SF8
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
type: ProteinReference
xref: uniprot E2RCV1 879
xref: PTHR10048:SF34
organism: Canis lupus familiaris

uniprot Q8BU31 84
type: UnificationXref
id: Q8BU31
db: uniprot

uniprot P21333 275
type: UnificationXref
id: P21333
db: uniprot

uniprot A0A3Q1M353 197
type: UnificationXref
id: A0A3Q1M353
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot Q5F352 329
xref: PTHR24070:SF189
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r113 1566
type: Stoichiometry
physical entity: Rho
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r113 1565
type: Stoichiometry
physical entity: Rho
stoichiometric coefficient: 1.0

Laminin subunit gamma-3
type: ProteinReference
xref: uniprot Q9Y6N6 1247
xref: PTHR10574:SF240
organism: Homo sapiens

uniprot F6WN64 214
type: UnificationXref
id: F6WN64
db: uniprot

PTHR10574:SF313
type: RelationshipXref
id: PTHR10574:SF313
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5QGA8 755
type: UnificationXref
id: A0A1D5QGA8
db: uniprot

Integrin alpha
type: Protein
entity reference: Integrin alpha
feature: ACTIVE 89
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa27 1416
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Alpha-actinin-3
type: ProteinReference
xref: uniprot Q0III9 735
xref: PTHR23167:SF22
organism: Bos taurus

Complex (Paxillin/Crk)
type: Complex
component stoichiometry: Paxillin s23 sa23 STOICHIOMETRY ID COMPLEX
component stoichiometry: Crk s24 sa24 STOICHIOMETRY ID COMPLEX
component: Crk
component: Paxillin
feature: COMPLEX BINDING FEATURE s215 a310 1413
feature: COMPLEX BINDING FEATURE s215 a310 1411
cellular location: cytoplasm

Tyrosine-protein phosphatase non-receptor type 12
type: ProteinReference
xref: uniprot G3V7Q4 280
xref: PTHR45983:SF3
organism: Rattus norvegicus

Integrin subunit alpha 1
type: ProteinReference
xref: uniprot J9NUT8 1045
xref: PTHR23220:SF22
organism: Canis lupus familiaris

LIM and senescent cell antigen-like-containing domain protein 1
type: ProteinReference
xref: uniprot Q99JW4 398
xref: PTHR24210:SF11
organism: Mus musculus

PTHR10574:SF303
type: RelationshipXref
id: PTHR10574:SF303
db: PANTHER Family
relationship type: By Homology

CRK like proto-oncogene, adaptor protein
type: ProteinReference
xref: uniprot F7E9T7 839
xref: PTHR19969:SF20
organism: Ornithorhynchus anatinus

uniprot Q9EPC1 1168
type: UnificationXref
id: Q9EPC1
db: uniprot

uniprot Q9WV32 254
type: UnificationXref
id: Q9WV32
db: uniprot

PTHR11915:SF442
type: RelationshipXref
id: PTHR11915:SF442
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r90 1598
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r90 1599
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

Paxillin-B
type: ProteinReference
xref: uniprot Q8MML5 1326
xref: PTHR24216:SF58
organism: Dictyostelium discoideum

ADP ribosylation factor 6
type: ProteinReference
xref: PTHR11711:SF379
xref: uniprot G3N3N1 363
organism: Bos taurus

uniprot A0A1D5QAU9 644
type: UnificationXref
id: A0A1D5QAU9
db: uniprot

uniprot F1PPQ7 442
type: UnificationXref
id: F1PPQ7
db: uniprot

uniprot E2RL20 631
type: UnificationXref
id: E2RL20
db: uniprot

uniprot O45815 1136
type: UnificationXref
id: O45815
db: uniprot

Integrin-linked kinase
type: ProteinReference
xref: uniprot Q6PHD6 859
organism: Danio rerio

Crk
type: Protein
entity reference: Crk
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

P00949
type: UnificationXref
id: P00949
db: PANTHER Pathway Component

uniprot F6Z8M9 600
type: UnificationXref
id: F6Z8M9
db: uniprot

P00947
type: UnificationXref
id: P00947
db: PANTHER Pathway Component

P00948
type: UnificationXref
id: P00948
db: PANTHER Pathway Component

Rhea, isoform B
type: ProteinReference
xref: uniprot Q9VSL8 1111
xref: PTHR19981:SF1
organism: Drosophila melanogaster

uniprot P12814 731
type: UnificationXref
id: P12814
db: uniprot

uniprot P42336 929
type: UnificationXref
id: P42336
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot F6Z879 655
organism: Monodelphis domestica

DnaJ homolog subfamily C member 27
type: ProteinReference
xref: uniprot A5D7F5 11
organism: Bos taurus

uniprot A0A0G2K3R1 90
type: UnificationXref
id: A0A0G2K3R1
db: uniprot

P00941
type: UnificationXref
id: P00941
db: PANTHER Pathway Component

PTHR24070:SF393
type: RelationshipXref
id: PTHR24070:SF393
db: PANTHER Family
relationship type: By Homology

P00942
type: UnificationXref
id: P00942
db: PANTHER Pathway Component

Collagen alpha-1(XII) chain
type: ProteinReference
xref: uniprot P13944 523
xref: PTHR24020:SF17
organism: Gallus gallus

P00940
type: UnificationXref
id: P00940
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r98 1578
type: Stoichiometry
physical entity: Cdc42
stoichiometric coefficient: 1.0

P00945
type: UnificationXref
id: P00945
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r98 1577
type: Stoichiometry
physical entity: Cdc42
stoichiometric coefficient: 1.0

P00946
type: UnificationXref
id: P00946
db: PANTHER Pathway Component

ncbitaxon 367110 319
type: UnificationXref
id: 367110
db: ncbitaxon

P00943
type: UnificationXref
id: P00943
db: PANTHER Pathway Component

P00944
type: UnificationXref
id: P00944
db: PANTHER Pathway Component

Actinin alpha 4
type: ProteinReference
xref: uniprot F6V4J5 719
xref: PTHR11915:SF425
organism: Xenopus tropicalis

ADP-ribosylation factor-like protein 1
type: ProteinReference
xref: uniprot P40616 606
xref: PTHR11711:SF41
organism: Homo sapiens

PTHR24070:SF388
type: RelationshipXref
id: PTHR24070:SF388
db: PANTHER Family
relationship type: By Homology

PTHR24070:SF385
type: RelationshipXref
id: PTHR24070:SF385
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR24418:SF94
xref: uniprot A0A3Q1LVP1 818
organism: Bos taurus

uniprot H2QJJ5 478
type: UnificationXref
id: H2QJJ5
db: uniprot

uniprot A2ARA8 415
type: UnificationXref
id: A2ARA8
db: uniprot

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
type: ProteinReference
xref: uniprot O97902 180
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QAU9 644
xref: PTHR48013:SF15
organism: Macaca mulatta

Csk s21 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Csk
stoichiometric coefficient: 1.0

LIM and senescent cell antigen-like-containing domain protein
type: ProteinReference
xref: PTHR24210:SF10
xref: uniprot A0A0G2KAE1 386
organism: Rattus norvegicus

uniprot Q00246 1285
type: UnificationXref
id: Q00246
db: uniprot

P00950
type: UnificationXref
id: P00950
db: PANTHER Pathway Component

P00951
type: UnificationXref
id: P00951
db: PANTHER Pathway Component

Collagen alpha-2(XI) chain
type: ProteinReference
xref: PTHR24023:SF509
xref: uniprot F1MRP6 435
organism: Bos taurus

Alpha-parvin
type: ProteinReference
xref: uniprot Q9NVD7 1172
xref: PTHR12114:SF6
organism: Homo sapiens

Crk
type: ProteinReference
xref: P00933
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Crk
comment: ENTITY_REFERENCE_NOTES=Long Name: Crk Synonym: Synonym not specified Accession: P00933
member entity reference: Crk-like protein
member entity reference: Uncharacterized protein
member entity reference: V-crk avian sarcoma virus CT10 oncogene homolog
member entity reference: CRK like proto-oncogene, adaptor protein
member entity reference: Adapter molecule crk

Collagen alpha-1(III) chain
type: ProteinReference
xref: PTHR24023:SF604
xref: uniprot P13941 521
organism: Rattus norvegicus

Collagen alpha-2(XI) chain
type: ProteinReference
xref: uniprot P13942 522
xref: PTHR24023:SF509
organism: Homo sapiens

FAK
type: Protein
entity reference: FAK
feature: FAK s148 a172 rs4
feature: ACTIVE 89
feature: FAK s148 a172 rs3
feature: Y925 FAK s148 a172 rs2
feature: Y397 FAK s148 a172 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9WTY9 164
organism: Rattus norvegicus

uniprot A0A0G2K5T3 863
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HL22 1108
xref: PTHR19981:SF7
organism: Macaca mulatta

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot H2R8U9 378
organism: Pan troglodytes

uniprot H2QDE6 476
type: UnificationXref
id: H2QDE6
db: uniprot

Alpha-actinin-4
type: ProteinReference
xref: PTHR23167:SF32
xref: uniprot A5D7D1 710
organism: Bos taurus

Csk
type: Protein
entity reference: Csk
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa21 1404
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot P27704 137
xref: PTHR24055:SF171
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H9J1 121
organism: Macaca mulatta

Complex (ILK/PINCH/ Parvin)
type: Complex
component stoichiometry: PINCH s375 sa85 STOICHIOMETRY ID COMPLEX
component stoichiometry: ILK s374 sa84 STOICHIOMETRY ID COMPLEX
component stoichiometry: Parvin s376 sa86 STOICHIOMETRY ID COMPLEX
component: Parvin
component: ILK
component: PINCH
feature: COMPLEX PARTICIPANT BINDING FEATURE s373 a552 1450
feature: COMPLEX BINDING FEATURE s373 a552 1447
feature: COMPLEX BINDING FEATURE s373 a552 1445
feature: COMPLEX BINDING FEATURE s373 a552 1443
cellular location: cytoplasm

uniprot A0A2I3SCU5 759
type: UnificationXref
id: A0A2I3SCU5
db: uniprot

Ras homolog family member B
type: ProteinReference
xref: PTHR24072:SF0
xref: uniprot F7FR08 1267
organism: Ornithorhynchus anatinus

uniprot D3ZKG5 1162
type: UnificationXref
id: D3ZKG5
db: uniprot

uniprot A0A0R4IKK9 91
type: UnificationXref
id: A0A0R4IKK9
db: uniprot

Rho family GTPase
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot C4M5Q7 685
organism: Entamoeba histolytica

uniprot A5PKJ7 1250
type: UnificationXref
id: A5PKJ7
db: uniprot

Shc
type: Protein
entity reference: Shc
feature: Shc s287 a421 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5Q7K7 1113
type: UnificationXref
id: A0A1D5Q7K7
db: uniprot

uniprot F7EG27 463
type: UnificationXref
id: F7EG27
db: uniprot

uniprot Q8BTI9 948
type: UnificationXref
id: Q8BTI9
db: uniprot

PTHR12391:SF4
type: RelationshipXref
id: PTHR12391:SF4
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__B_Raf-RIGHT__B_Raf-_r105
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r105 1608
participant stoichiometry: PARTICIPANT STOICHIOMETRY r105 1609
left: B-Raf
interaction type: STATE_TRANSITION
right: B-Raf

SHC-transforming protein 1
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot Q0IIE2 1317
organism: Bos taurus

uniprot P53478 1137
type: UnificationXref
id: P53478
db: uniprot

PTHR12391:SF1
type: RelationshipXref
id: PTHR12391:SF1
db: PANTHER Family
relationship type: By Homology

uniprot D4A3L3 1188
type: UnificationXref
id: D4A3L3
db: uniprot

PTHR12391:SF0
type: RelationshipXref
id: PTHR12391:SF0
db: PANTHER Family
relationship type: By Homology

Shc s86 sa66 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.02298445744145208
comment: MODIFICATION_RESIDUE_NAME=

COL2A1 isoform 2
type: ProteinReference
xref: PTHR24023:SF58
xref: uniprot H2R193 484
organism: Pan troglodytes

Laminin subunit beta 1
type: ProteinReference
xref: PTHR10574:SF233
xref: uniprot F7A5M5 1203
organism: Monodelphis domestica

P00906
type: UnificationXref
id: P00906
db: PANTHER Pathway Component

P00909
type: UnificationXref
id: P00909
db: PANTHER Pathway Component

P00908
type: UnificationXref
id: P00908
db: PANTHER Pathway Component

P00907
type: UnificationXref
id: P00907
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZGX8 299
xref: PTHR24070:SF245
organism: Macaca mulatta

uniprot Q8BUR4 754
type: UnificationXref
id: Q8BUR4
db: uniprot

uniprot Q9JM76 249
type: UnificationXref
id: Q9JM76
db: uniprot

COL4A2 isoform 1
type: ProteinReference
xref: PTHR24023:SF588
xref: uniprot K7C8W0 494
organism: Pan troglodytes

uniprot F7DMS9 361
type: UnificationXref
id: F7DMS9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF446
xref: uniprot F6R9F4 1125
organism: Monodelphis domestica

uniprot P23727 925
type: UnificationXref
id: P23727
db: uniprot

P00911
type: UnificationXref
id: P00911
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: PTHR10574:SF313
xref: uniprot F7BDD8 1204
organism: Macaca mulatta

P00910
type: UnificationXref
id: P00910
db: PANTHER Pathway Component

P00913
type: UnificationXref
id: P00913
db: PANTHER Pathway Component

P00912
type: UnificationXref
id: P00912
db: PANTHER Pathway Component

P00915
type: UnificationXref
id: P00915
db: PANTHER Pathway Component

ncbitaxon 9823 177
type: UnificationXref
id: 9823
db: ncbitaxon

P00914
type: UnificationXref
id: P00914
db: PANTHER Pathway Component

P00917
type: UnificationXref
id: P00917
db: PANTHER Pathway Component

P00916
type: UnificationXref
id: P00916
db: PANTHER Pathway Component

uniprot H2Q644 1036
type: UnificationXref
id: H2Q644
db: uniprot

Paxillin s65 sa71 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot H2PZI4 474
type: UnificationXref
id: H2PZI4
db: uniprot

P00919
type: UnificationXref
id: P00919
db: PANTHER Pathway Component

uniprot F6PQC9 34
type: UnificationXref
id: F6PQC9
db: uniprot

P00918
type: UnificationXref
id: P00918
db: PANTHER Pathway Component

uniprot E2RCV1 879
type: UnificationXref
id: E2RCV1
db: uniprot

PTHR24020:SF18
type: RelationshipXref
id: PTHR24020:SF18
db: PANTHER Family
relationship type: By Homology

PTHR24020:SF17
type: RelationshipXref
id: PTHR24020:SF17
db: PANTHER Family
relationship type: By Homology

uniprot P61588 1281
type: UnificationXref
id: P61588
db: uniprot

uniprot P12110 519
type: UnificationXref
id: P12110
db: uniprot

PTHR24020:SF15
type: RelationshipXref
id: PTHR24020:SF15
db: PANTHER Family
relationship type: By Homology

uniprot Q04970 323
type: UnificationXref
id: Q04970
db: uniprot

PTHR24020:SF13
type: RelationshipXref
id: PTHR24020:SF13
db: PANTHER Family
relationship type: By Homology

uniprot Q9R0B6 1246
type: UnificationXref
id: Q9R0B6
db: uniprot

uniprot H2R296 485
type: UnificationXref
id: H2R296
db: uniprot

uniprot H2QNG6 911
type: UnificationXref
id: H2QNG6
db: uniprot

uniprot F7GNU4 1030
type: UnificationXref
id: F7GNU4
db: uniprot

uniprot P18564 794
type: UnificationXref
id: P18564
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot Q9WTU6 1350
xref: PTHR24055:SF172
organism: Mus musculus

P00924
type: UnificationXref
id: P00924
db: PANTHER Pathway Component

P00923
type: UnificationXref
id: P00923
db: PANTHER Pathway Component

p130CAS
type: Protein
entity reference: p130CAS
feature: p130CAS s183 a245 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

P00922
type: UnificationXref
id: P00922
db: PANTHER Pathway Component

P00921
type: UnificationXref
id: P00921
db: PANTHER Pathway Component

uniprot A0A1D5QZT0 756
type: UnificationXref
id: A0A1D5QZT0
db: uniprot

uniprot P02458 501
type: UnificationXref
id: P02458
db: uniprot

P00920
type: UnificationXref
id: P00920
db: PANTHER Pathway Component

PINCH
type: ProteinReference
xref: P00921
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.PINCH
comment: ENTITY_REFERENCE_NOTES=
member entity reference: LIM and senescent cell antigen-like-containing domain protein 2
member entity reference: LIM and senescent cell antigen-like-containing domain protein
member entity reference: LIM and senescent cell antigen-like-containing domain protein 1
member entity reference: LIM domain-containing protein

PINCH s375 sa85 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PINCH
stoichiometric coefficient: 1.0

PTHR24020:SF29
type: RelationshipXref
id: PTHR24020:SF29
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot Q61532 155
xref: PTHR24055:SF171
organism: Mus musculus

uniprot Q5ZJI7 241
type: UnificationXref
id: Q5ZJI7
db: uniprot

AcTiniN
type: ProteinReference
xref: PTHR11915:SF442
xref: uniprot Q23158 736
organism: Caenorhabditis elegans

uniprot Q61140 172
type: UnificationXref
id: Q61140
db: uniprot

P00929
type: UnificationXref
id: P00929
db: PANTHER Pathway Component

P00928
type: UnificationXref
id: P00928
db: PANTHER Pathway Component

uniprot F6XG33 1025
type: UnificationXref
id: F6XG33
db: uniprot

P00927
type: UnificationXref
id: P00927
db: PANTHER Pathway Component

P00926
type: UnificationXref
id: P00926
db: PANTHER Pathway Component

P00925
type: UnificationXref
id: P00925
db: PANTHER Pathway Component

Rho GTPase-activating protein 10
type: ProteinReference
xref: PTHR12552:SF5
xref: uniprot Q08DP6 678
organism: Bos taurus

Arp2/3 complex 34 kDa subunit
type: ProteinReference
xref: PTHR12058:SF0
xref: uniprot A0A2I3TL93 202
organism: Pan troglodytes

uniprot P26012 797
type: UnificationXref
id: P26012
db: uniprot

uniprot Q3ZBW5 1292
type: UnificationXref
id: Q3ZBW5
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9N272 163
organism: Pan troglodytes

P00933
type: UnificationXref
id: P00933
db: PANTHER Pathway Component

uniprot Q9JLI2 573
type: UnificationXref
id: Q9JLI2
db: uniprot

P00932
type: UnificationXref
id: P00932
db: PANTHER Pathway Component

uniprot P02462 504
type: UnificationXref
id: P02462
db: uniprot

P00935
type: UnificationXref
id: P00935
db: PANTHER Pathway Component

P00934
type: UnificationXref
id: P00934
db: PANTHER Pathway Component

P00931
type: UnificationXref
id: P00931
db: PANTHER Pathway Component

P00930
type: UnificationXref
id: P00930
db: PANTHER Pathway Component

Ras
type: Protein
entity reference: Ras
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

P00937
type: UnificationXref
id: P00937
db: PANTHER Pathway Component

P00936
type: UnificationXref
id: P00936
db: PANTHER Pathway Component

P00939
type: UnificationXref
id: P00939
db: PANTHER Pathway Component

Fibronectin
type: Protein
entity reference: Fibronectin
feature: COMPLEX PARTICIPANT BINDING FEATURE s77 sa83 1474
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ADP ribosylation factor 5
type: ProteinReference
xref: PTHR11711:SF357
xref: uniprot Q6P7Z6 621
organism: Xenopus tropicalis

P00938
type: UnificationXref
id: P00938
db: PANTHER Pathway Component

Integrin subunit alpha 11
type: ProteinReference
xref: PTHR23220:SF21
xref: uniprot F1LUU1 1014
organism: Rattus norvegicus

PTHR11711:SF119
type: RelationshipXref
id: PTHR11711:SF119
db: PANTHER Family
relationship type: By Homology

PTHR46221:SF5
type: RelationshipXref
id: PTHR46221:SF5
db: PANTHER Family
relationship type: By Homology

PTHR24020:SF39
type: RelationshipXref
id: PTHR24020:SF39
db: PANTHER Family
relationship type: By Homology

uniprot D3ZQM3 1009
type: UnificationXref
id: D3ZQM3
db: uniprot

PTHR24070:SF395
type: RelationshipXref
id: PTHR24070:SF395
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot F7CS91 1263
organism: Monodelphis domestica

Integrin alpha-8
type: ProteinReference
xref: uniprot A2ARA8 415
xref: PTHR23220:SF5
organism: Mus musculus

Integrin beta-6
type: ProteinReference
xref: uniprot Q6AYF4 807
xref: PTHR10082:SF11
organism: Rattus norvegicus

uniprot P80747 801
type: UnificationXref
id: P80747
db: uniprot

uniprot Q62844 1101
type: UnificationXref
id: Q62844
db: uniprot

uniprot A5PJP8 647
type: UnificationXref
id: A5PJP8
db: uniprot

Rho family GTPase
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot C4M5Z7 687
organism: Entamoeba histolytica

AGAP001381-PA
type: ProteinReference
xref: PTHR10574:SF303
xref: uniprot Q7PXF5 1240
organism: Anopheles gambiae

uniprot A8X1S0 1332
type: UnificationXref
id: A8X1S0
db: uniprot

uniprot P63258 1143
type: UnificationXref
id: P63258
db: uniprot

uniprot D3ZN51 1008
type: UnificationXref
id: D3ZN51
db: uniprot

uniprot F6TX60 448
type: UnificationXref
id: F6TX60
db: uniprot

Complex (alpha actinin/Actin)
type: Complex
component stoichiometry: Actin s44 sa44 STOICHIOMETRY ID COMPLEX
component stoichiometry: alpha actinin s43 sa43 STOICHIOMETRY ID COMPLEX
component: Actin
component: alpha actinin
feature: COMPLEX BINDING FEATURE s263 a394 1497
feature: COMPLEX BINDING FEATURE s263 a394 1499
cellular location: cytoplasm

Parvin, beta
type: ProteinReference
xref: PTHR12114:SF7
xref: uniprot D3ZKG5 1162
organism: Rattus norvegicus

uniprot A0A2I3T078 761
type: UnificationXref
id: A0A2I3T078
db: uniprot

Integrin alpha-V
type: ProteinReference
xref: uniprot P06756 1050
xref: PTHR23220:SF4
organism: Homo sapiens

uniprot H2RA86 127
type: UnificationXref
id: H2RA86
db: uniprot

Integrin beta-7
type: ProteinReference
xref: PTHR10082:SF36
xref: uniprot P26010 795
organism: Homo sapiens

Integrin beta-7
type: ProteinReference
xref: PTHR10082:SF36
xref: uniprot P26011 796
organism: Mus musculus

Integrin beta-8
type: ProteinReference
xref: uniprot P26012 797
xref: PTHR10082:SF9
organism: Homo sapiens

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 61

uniprot P35831 282
type: UnificationXref
id: P35831
db: uniprot

Y397 FAK s17 sa17 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y397
feature location: Y397 FAK s17 sa17 rs1 Y397
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y397
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4400218803743385

Vinculin s31 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Vinculin
stoichiometric coefficient: 1.0

uniprot P60710 1139
type: UnificationXref
id: P60710
db: uniprot

uniprot A0A2I3S4E5 406
type: UnificationXref
id: A0A2I3S4E5
db: uniprot

uniprot F7BD74 656
type: UnificationXref
id: F7BD74
db: uniprot

uniprot E2QTM5 23
type: UnificationXref
id: E2QTM5
db: uniprot

uniprot P92208 1345
type: UnificationXref
id: P92208
db: uniprot

uniprot Q61001 1236
type: UnificationXref
id: Q61001
db: uniprot

Y925 FAK s148 a172 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y925
feature location: Y925 FAK s148 a172 rs2 Y925
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.58380694263043
comment: MODIFICATION_RESIDUE_NAME=Y925

PTHR10574:SF36
type: RelationshipXref
id: PTHR10574:SF36
db: PANTHER Family
relationship type: By Homology

uniprot P45985 664
type: UnificationXref
id: P45985
db: uniprot

Paxillin s22 sa22 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F7EJH1 974
type: UnificationXref
id: F7EJH1
db: uniprot

Ras-related protein Rap-2a
type: ProteinReference
xref: PTHR24070:SF221
xref: uniprot P10114 58
organism: Homo sapiens

uniprot F6X717 774
type: UnificationXref
id: F6X717
db: uniprot

Complex (Vinculin/PIP2/ VASP)
type: Complex
component stoichiometry: VASP s92 sa101 STOICHIOMETRY ID COMPLEX
component stoichiometry: Vinculin s90 sa99 STOICHIOMETRY ID COMPLEX
component stoichiometry: PIP2 s91 sa100 STOICHIOMETRY ID COMPLEX
component: Vinculin
component: PIP2
component: VASP
feature: COMPLEX BINDING FEATURE s372 a621 1367
feature: COMPLEX BINDING FEATURE s372 a621 1369
feature: COMPLEX BINDING FEATURE s372 a621 1371
cellular location: cytoplasm

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F7BD74 656
organism: Monodelphis domestica

ADP ribosylation factor-like GTPase 1
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot Q5BJ82 615
organism: Xenopus tropicalis

uniprot Q5ZMW5 679
type: UnificationXref
id: Q5ZMW5
db: uniprot

uniprot A0A452DI16 629
type: UnificationXref
id: A0A452DI16
db: uniprot

PINCH s61 sa88 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PINCH
stoichiometric coefficient: 1.0

uniprot H2QKR5 480
type: UnificationXref
id: H2QKR5
db: uniprot

ADP-ribosylation factor 6
type: ProteinReference
xref: uniprot H2Q894 364
xref: PTHR11711:SF379
organism: Pan troglodytes

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: uniprot Q04982 200
xref: PTHR44329:SF47
organism: Gallus gallus

ncbitaxon 44689 61
type: UnificationXref
id: 44689
db: ncbitaxon

Actinin alpha 2
type: ProteinReference
xref: uniprot F7F6L1 724
xref: PTHR11915:SF429
organism: Ornithorhynchus anatinus

uniprot Q9ULH1 188
type: UnificationXref
id: Q9ULH1
db: uniprot

Talin-1
type: ProteinReference
xref: uniprot P26039 1110
xref: PTHR19981:SF7
organism: Mus musculus

uniprot H2R1A9 975
type: UnificationXref
id: H2R1A9
db: uniprot

uniprot F6URT1 359
type: UnificationXref
id: F6URT1
db: uniprot

p130CAS s78 sa90 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p130CAS
stoichiometric coefficient: 1.0

Integrin beta
type: Protein
entity reference: Integrin beta
feature: ACTIVE 89
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa29 1420
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Rho family GTPase 2
type: ProteinReference
xref: PTHR24072:SF21
xref: uniprot F7CZP3 1264
organism: Monodelphis domestica

uniprot A0A1D5RI38 583
type: UnificationXref
id: A0A1D5RI38
db: uniprot

uniprot Q8INQ9 396
type: UnificationXref
id: Q8INQ9
db: uniprot

uniprot Q6P4X1 808
type: UnificationXref
id: Q6P4X1
db: uniprot

LAMinin related. See also lmb
type: ProteinReference
xref: uniprot G5ECE3 1206
xref: PTHR10574:SF400
organism: Caenorhabditis elegans

uniprot F1NRH2 439
type: UnificationXref
id: F1NRH2
db: uniprot

LIM and senescent cell antigen-like-containing domain protein 2
type: ProteinReference
xref: PTHR24210:SF10
xref: uniprot Q2KJ33 394
organism: Bos taurus

uniprot F1MBU9 884
type: UnificationXref
id: F1MBU9
db: uniprot

uniprot F6ZZG9 1129
type: UnificationXref
id: F6ZZG9
db: uniprot

Vinculin
type: ProteinReference
xref: P00937
comment: ENTITY_REFERENCE_NOTES=Long Name: Vinculin Synonym: Synonym not specified Accession: P00937
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Vinculin
member entity reference: Vinculin
member entity reference: VCL isoform 2
member entity reference: Uncharacterized protein

FN1 isoform 1
type: ProteinReference
xref: uniprot H2R1A9 975
xref: PTHR19143:SF267
organism: Pan troglodytes

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Src-RIGHT__Src-_re61
control type: INHIBITION
controller: Complex (Csk/Paxillin)

STATE_TRANSITION
type: InteractionVocabulary

Rho GTPase-activating protein 26
type: ProteinReference
xref: uniprot Q6ZQ82 681
xref: PTHR12552:SF4
organism: Mus musculus

SOS s84 sa64 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Arf1-RIGHT__Arf1-_r117
controller: ASAP1

Rho GTPase-activating protein 26
type: ProteinReference
xref: PTHR12552:SF4
xref: uniprot Q9UNA1 682
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r46 1523
type: Stoichiometry
physical entity: Complex (Integrin beta/Integrin _alpha)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r46 1524
type: Stoichiometry
physical entity: Complex (Fibronectin/Laminin/ Collagen)
stoichiometric coefficient: 1.0

uniprot D4AC70 424
type: UnificationXref
id: D4AC70
db: uniprot

PARTICIPANT STOICHIOMETRY r46 1525
type: Stoichiometry
physical entity: Complex (Integrin beta/Integrin _alpha/ Integrin beta/Integrin _alpha/ Collagen/Laminin/ Fibronectin)
stoichiometric coefficient: 1.0

uniprot F6PKK7 1095
type: UnificationXref
id: F6PKK7
db: uniprot

Rap guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot Q13905 748
xref: PTHR23113:SF224
organism: Homo sapiens

Y925 FAK s17 sa17 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y925
feature location: Y925 FAK s17 sa17 rs2 Y925
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.58380694263043
comment: MODIFICATION_RESIDUE_NAME=Y925

Extracellular signal-regulated kinase 1
type: ProteinReference
xref: uniprot Q5A1D3 149
xref: PTHR24055:SF158
organism: Candida albicans

uniprot A0A2I3RUR0 404
type: UnificationXref
id: A0A2I3RUR0
db: uniprot

Collagen alpha-3(IX) chain
type: ProteinReference
xref: PTHR24023:SF866
xref: uniprot Q14050 554
organism: Homo sapiens

PTHR10155:SF10
type: RelationshipXref
id: PTHR10155:SF10
db: PANTHER Family
relationship type: By Homology

Caveolin-1
type: ProteinReference
xref: uniprot P41350 350
xref: PTHR10844:SF18
organism: Rattus norvegicus

uniprot F7FMR3 1266
type: UnificationXref
id: F7FMR3
db: uniprot

Collagen alpha-2(IX) chain
type: ProteinReference
xref: uniprot Q14055 555
xref: PTHR24023:SF906
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7AGY1 459
xref: PTHR24020:SF17
organism: Monodelphis domestica

Collagen
type: Protein
entity reference: Collagen
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa12 1496
comment: SPECIES_TYPE=PROTEIN

Integrin alpha-V
type: ProteinReference
xref: PTHR23220:SF4
xref: uniprot P26008 1065
organism: Gallus gallus

Integrin alpha-6
type: ProteinReference
xref: PTHR23220:SF9
xref: uniprot P26007 1064
organism: Gallus gallus

Integrin alpha-3
type: ProteinReference
xref: PTHR23220:SF89
xref: uniprot P26006 1063
organism: Homo sapiens

uniprot P45983 1341
type: UnificationXref
id: P45983
db: uniprot

uniprot F1MAA7 1195
type: UnificationXref
id: F1MAA7
db: uniprot

uniprot Q63768 845
type: UnificationXref
id: Q63768
db: uniprot

Paxillin
type: ProteinReference
xref: uniprot Q8VI36 1327
xref: PTHR24216:SF11
organism: Mus musculus

uniprot F6WN02 213
type: UnificationXref
id: F6WN02
db: uniprot

PARTICIPANT STOICHIOMETRY r103 1618
type: Stoichiometry
physical entity: Jnk
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r103 1617
type: Stoichiometry
physical entity: Jnk
stoichiometric coefficient: 1.0

uniprot P52198 1277
type: UnificationXref
id: P52198
db: uniprot

Integrin alpha-PS4
type: ProteinReference
xref: uniprot Q9V7A4 1089
xref: PTHR23220:SF123
organism: Drosophila melanogaster

uniprot F1RDG9 1094
type: UnificationXref
id: F1RDG9
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot O46404 919
organism: Bos taurus

ncbitaxon 10228 588
type: UnificationXref
id: 10228
db: ncbitaxon

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot Q6NVA9 1154
xref: PTHR11937:SF477
organism: Xenopus tropicalis

uniprot A0A2I3S2J2 707
type: UnificationXref
id: A0A2I3S2J2
db: uniprot

uniprot O88763 922
type: UnificationXref
id: O88763
db: uniprot

Ras-related protein Rap-2c
type: ProteinReference
xref: PTHR24070:SF200
xref: uniprot Q08DI5 72
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GXE0 1032
xref: PTHR23220:SF3
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot B3RIM6 1255
xref: PTHR24072:SF168
organism: Trichoplax adhaerens

Integrin alpha-9
type: ProteinReference
xref: uniprot B8JK39 1005
xref: PTHR23220:SF69
organism: Mus musculus

uniprot Q3V3R4 1075
type: UnificationXref
id: Q3V3R4
db: uniprot

Vinculin s59 sa68 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Vinculin
stoichiometric coefficient: 1.0

uniprot A0A3Q1MHU3 333
type: UnificationXref
id: A0A3Q1MHU3
db: uniprot

Monosiga brevicollis
type: BioSource
xref: ncbitaxon 81824 1119

uniprot O35099 133
type: UnificationXref
id: O35099
db: uniprot

ncbitaxon 7955 16
type: UnificationXref
id: 7955
db: ncbitaxon

Collagen alpha-6(IV) chain
type: ProteinReference
xref: uniprot Q14031 553
xref: PTHR24023:SF533
organism: Homo sapiens

PTHR11937:SF414
type: RelationshipXref
id: PTHR11937:SF414
db: PANTHER Family
relationship type: By Homology

uniprot Q5HZE6 1294
type: UnificationXref
id: Q5HZE6
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot Q8WQM5 992
xref: PTHR24418:SF373
organism: Strongylocentrotus purpuratus

uniprot D4A5Q1 877
type: UnificationXref
id: D4A5Q1
db: uniprot

uniprot P48059 393
type: UnificationXref
id: P48059
db: uniprot

Tyrosine protein-kinase src-1
type: ProteinReference
xref: PTHR24418:SF430
xref: uniprot G5EE56 987
organism: Caenorhabditis elegans

uniprot Q9Y490 1112
type: UnificationXref
id: Q9Y490
db: uniprot

Collagen alpha-3(IV) chain
type: ProteinReference
xref: PTHR24023:SF980
xref: uniprot Q9QZS0 576
organism: Mus musculus

uniprot F6QYS6 772
type: UnificationXref
id: F6QYS6
db: uniprot

uniprot Q9VX82 253
type: UnificationXref
id: Q9VX82
db: uniprot

uniprot E3K4I1 1122
type: UnificationXref
id: E3K4I1
db: uniprot

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot Q16659 147
xref: PTHR24055:SF171
organism: Homo sapiens

uniprot P15153 692
type: UnificationXref
id: P15153
db: uniprot

Collagen alpha-3(IV) chain
type: ProteinReference
xref: PTHR24023:SF980
xref: uniprot Q01955 544
organism: Homo sapiens

uniprot K7D0T5 1214
type: UnificationXref
id: K7D0T5
db: uniprot

uniprot O54890 783
type: UnificationXref
id: O54890
db: uniprot

uniprot Q1AAU6 183
type: UnificationXref
id: Q1AAU6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF221
xref: uniprot A0A3Q1MGL7 7
organism: Bos taurus

uniprot H2R8U9 378
type: UnificationXref
id: H2R8U9
db: uniprot

Grb2
type: ProteinReference
xref: P00910
standard name: Growth factor receptor-bound protein 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Growth factor receptor bound protein 2 Synonym: Growth factor receptor bound protein 2,grb2 Accession: P00910
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Grb2
member entity reference: GRB2-related adapter protein
member entity reference: Growth factor receptor-bound protein 2
member entity reference: Growth factor receptor-bound protein 2a

Ras-related protein Rap-1b
type: ProteinReference
xref: PTHR24070:SF393
xref: uniprot Q640R7 77
organism: Xenopus tropicalis

Collagen alpha-1(II) chain
type: ProteinReference
xref: PTHR24023:SF58
xref: uniprot P28481 535
organism: Mus musculus

Predicted protein
type: ProteinReference
xref: uniprot A7S9Y5 1253
xref: PTHR24072:SF168
organism: Nematostella vectensis

uniprot J9P5W6 129
type: UnificationXref
id: J9P5W6
db: uniprot

Integrin beta
type: ProteinReference
xref: PTHR10082:SF42
xref: uniprot A0A2I3SZX7 760
organism: Pan troglodytes

uniprot F6R9F4 1125
type: UnificationXref
id: F6R9F4
db: uniprot

uniprot F6VPD5 36
type: UnificationXref
id: F6VPD5
db: uniprot

PTHR24216:SF58
type: RelationshipXref
id: PTHR24216:SF58
db: PANTHER Family
relationship type: By Homology

uniprot P11215 1053
type: UnificationXref
id: P11215
db: uniprot

uniprot A8XIF5 1254
type: UnificationXref
id: A8XIF5
db: uniprot

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot F1MBU9 884
organism: Bos taurus

uniprot F1P630 1333
type: UnificationXref
id: F1P630
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot Q8NEB9 949
organism: Homo sapiens

Alpha-actinin-2
type: ProteinReference
xref: uniprot F6VRJ5 720
xref: PTHR11915:SF429
organism: Macaca mulatta

p130CAS s182 a244 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.9229354047838125
comment: MODIFICATION_RESIDUE_NAME=

Caveolin-1
type: ProteinReference
xref: PTHR10844:SF18
xref: uniprot Q03135 353
organism: Homo sapiens

Rap guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot A0A2I3SBV7 745
xref: PTHR23113:SF224
organism: Pan troglodytes

Arp2/3 complex 34 kDa subunit
type: ProteinReference
xref: uniprot A0A1D5RJ31 201
xref: PTHR12058:SF0
organism: Macaca mulatta

uniprot F6ZDE9 1201
type: UnificationXref
id: F6ZDE9
db: uniprot

Collagen type XVII alpha 1 chain
type: ProteinReference
xref: PTHR24023:SF891
xref: uniprot H2Q2J4 475
organism: Pan troglodytes

Integrin beta-PS
type: ProteinReference
xref: PTHR10082:SF41
xref: uniprot P11584 790
organism: Drosophila melanogaster

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P27361 135
xref: PTHR24055:SF393
organism: Homo sapiens

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A7S0V7 1115
organism: Nematostella vectensis

uniprot Q9Y6R4 167
type: UnificationXref
id: Q9Y6R4
db: uniprot

Collagen alpha-2(VIII) chain
type: ProteinReference
xref: uniprot P25318 532
xref: PTHR24023:SF1027
organism: Mus musculus

Integrin alpha s64 sa70 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Integrin alpha
stoichiometric coefficient: 2.0

uniprot A0A3Q1MXS2 1004
type: UnificationXref
id: A0A3Q1MXS2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7AG99 458
xref: PTHR24020:SF13
organism: Macaca mulatta

uniprot P84079 611
type: UnificationXref
id: P84079
db: uniprot

ncbitaxon 7668 582
type: UnificationXref
id: 7668
db: ncbitaxon

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q01986 144
xref: PTHR48013:SF5
organism: Rattus norvegicus

uniprot Q64727 961
type: UnificationXref
id: Q64727
db: uniprot

uniprot Q17031 969
type: UnificationXref
id: Q17031
db: uniprot

Integrin alpha-7
type: ProteinReference
xref: uniprot Q61738 1077
xref: PTHR23220:SF90
organism: Mus musculus

Integrin alpha-6
type: ProteinReference
xref: uniprot Q61739 1078
xref: PTHR23220:SF9
organism: Mus musculus

Phosphatidylinositol 3-kinase piki-1
type: ProteinReference
xref: uniprot G5EDY0 906
xref: PTHR10048:SF64
organism: Caenorhabditis elegans

uniprot E2RPB0 882
type: UnificationXref
id: E2RPB0
db: uniprot

Actin
type: Protein
entity reference: Actin
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa32 1426
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Collagen
type: Protein
entity reference: Collagen
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa5 1362
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q99715 570
type: UnificationXref
id: Q99715
db: uniprot

uniprot Q01955 544
type: UnificationXref
id: Q01955
db: uniprot

uniprot Q6PF93 943
type: UnificationXref
id: Q6PF93
db: uniprot

Map2k3 protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot B1H230 648
organism: Rattus norvegicus

Protein CBR-EMB-9
type: ProteinReference
xref: uniprot A8XAF1 417
xref: PTHR24023:SF1005
organism: Caenorhabditis briggsae

uniprot P20908 530
type: UnificationXref
id: P20908
db: uniprot

PTHR11937:SF446
type: RelationshipXref
id: PTHR11937:SF446
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3STF2 708
type: UnificationXref
id: A0A2I3STF2
db: uniprot

PTHR11937:SF445
type: RelationshipXref
id: PTHR11937:SF445
db: PANTHER Family
relationship type: By Homology

Dual-specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot F1NYZ2 650
organism: Gallus gallus

LIM and senescent cell antigen-like-containing domain protein 2
type: ProteinReference
xref: uniprot Q7Z4I7 395
xref: PTHR24210:SF10
organism: Homo sapiens

Rac family small GTPase 3a
type: ProteinReference
xref: PTHR24072:SF301
xref: uniprot Q6DGB7 700
organism: Danio rerio

Laminin-like protein epi-1
type: ProteinReference
xref: uniprot Q21313 1233
xref: PTHR10574:SF406
organism: Caenorhabditis elegans

uniprot Q1RMJ6 1287
type: UnificationXref
id: Q1RMJ6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot E2RPB0 882
organism: Canis lupus familiaris

uniprot Q3T035 237
type: UnificationXref
id: Q3T035
db: uniprot

uniprot P12111 520
type: UnificationXref
id: P12111
db: uniprot

uniprot Q07889 383
type: UnificationXref
id: Q07889
db: uniprot

Stress-activated protein kinase jnk-1
type: ProteinReference
xref: PTHR24055:SF341
xref: uniprot Q8WQG9 1347
organism: Caenorhabditis elegans

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot F6QTB5 211
xref: PTHR10709:SF11
organism: Ornithorhynchus anatinus

uniprot P53420 540
type: UnificationXref
id: P53420
db: uniprot

Laminin subunit beta-2
type: ProteinReference
xref: uniprot P55268 1225
xref: PTHR10574:SF36
organism: Homo sapiens

uniprot A7SEB1 1117
type: UnificationXref
id: A7SEB1
db: uniprot

NRAS isoform 1
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot H2PZQ7 302
organism: Pan troglodytes

uniprot F6XD59 451
type: UnificationXref
id: F6XD59
db: uniprot

Protein CBR-RHO-1
type: ProteinReference
xref: uniprot A8XIF5 1254
xref: PTHR24072:SF168
organism: Caenorhabditis briggsae

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: uniprot A0A3Q1MNG1 645
xref: PTHR48013:SF21
organism: Bos taurus

ELMO
type: ProteinReference
xref: P00917
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.ELMO
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: ELMO Synonym: Synonym not specified Accession: P00917
member entity reference: Engulfment and cell motility protein 1
member entity reference: Engulfment and cell motility 2
member entity reference: Engulfment and cell motility 1
member entity reference: Uncharacterized protein
member entity reference: Engulfment and cell motility 2, ced-12 homolog (C. elegans), isoform CRA_b
member entity reference: Engulfment and cell motility protein 2
member entity reference: ELMO2 isoform 11
member entity reference: Engulfment and cell motility protein 1 isoform 1

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: uniprot Q64143 942
xref: PTHR10155:SF2
organism: Mus musculus

Collagen alpha-4(IV) chain
type: ProteinReference
xref: PTHR24023:SF714
xref: uniprot Q9QZR9 575
organism: Mus musculus

AGAP006826-PA
type: ProteinReference
xref: uniprot Q7QIG1 1083
xref: PTHR23220:SF123
organism: Anopheles gambiae

PTHR11937:SF421
type: RelationshipXref
id: PTHR11937:SF421
db: PANTHER Family
relationship type: By Homology

uniprot P26008 1065
type: UnificationXref
id: P26008
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q63844 157
organism: Mus musculus

uniprot P48148 1276
type: UnificationXref
id: P48148
db: uniprot

uniprot A0A1D5QJ66 92
type: UnificationXref
id: A0A1D5QJ66
db: uniprot

PTK2B isoform 2
type: ProteinReference
xref: uniprot H2QVX8 826
xref: PTHR24418:SF94
organism: Pan troglodytes

uniprot Q00944 830
type: UnificationXref
id: Q00944
db: uniprot

PTHR24210:SF11
type: RelationshipXref
id: PTHR24210:SF11
db: PANTHER Family
relationship type: By Homology

PTHR24210:SF10
type: RelationshipXref
id: PTHR24210:SF10
db: PANTHER Family
relationship type: By Homology

Vinculin
type: Protein
entity reference: Vinculin
feature: ACTIVE 89
feature: COMPLEX PARTICIPANT BINDING FEATURE s87 sa96 1502
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P61225 64
type: UnificationXref
id: P61225
db: uniprot

uniprot F7F073 49
type: UnificationXref
id: F7F073
db: uniprot

Integrin alpha s14 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Integrin alpha
stoichiometric coefficient: 1.0

uniprot P02454 500
type: UnificationXref
id: P02454
db: uniprot

uniprot P60766 966
type: UnificationXref
id: P60766
db: uniprot

uniprot W4ZCX2 581
type: UnificationXref
id: W4ZCX2
db: uniprot

uniprot A0A0G2K023 1175
type: UnificationXref
id: A0A0G2K023
db: uniprot

uniprot P62331 366
type: UnificationXref
id: P62331
db: uniprot

Actinin alpha 2
type: ProteinReference
xref: uniprot D3ZCV0 713
xref: PTHR11915:SF429
organism: Rattus norvegicus

uniprot F7FG54 776
type: UnificationXref
id: F7FG54
db: uniprot

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: uniprot H2QDN0 124
organism: Pan troglodytes

ncbitaxon 9258 35
type: UnificationXref
id: 9258
db: ncbitaxon

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F7BWW9 377
xref: PTHR23113:SF168
organism: Ornithorhynchus anatinus

AGAP004303-PA
type: ProteinReference
xref: PTHR23220:SF123
xref: uniprot Q7QAC8 1082
organism: Anopheles gambiae

alpha actinin
type: ProteinReference
xref: P00928
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC._alpha__br_actinin
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Alpha-actinin-2
member entity reference: Uncharacterized protein
member entity reference: Alpha-actinin A
member entity reference: Actinin alpha 3
member entity reference: Actinin alpha 2
member entity reference: AcTiniN
member entity reference: Alpha-actinin-4
member entity reference: Alpha-actinin-3
member entity reference: Protein CBR-ATN-1
member entity reference: Actinin, alpha 1
member entity reference: Actinin alpha 4
member entity reference: Actinin alpha 1
member entity reference: Alpha-actinin-1
member entity reference: MICAL-like protein 1
member entity reference: ACTN2 isoform 3
member entity reference: MICAL-like 1

uniprot A0A2I3RYR8 757
type: UnificationXref
id: A0A2I3RYR8
db: uniprot

uniprot E2RKC5 1256
type: UnificationXref
id: E2RKC5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12771:SF23
xref: uniprot Q5ZL97 343
organism: Gallus gallus

PTHR46037:SF4
type: RelationshipXref
id: PTHR46037:SF4
db: PANTHER Family
relationship type: By Homology

uniprot Q63789 941
type: UnificationXref
id: Q63789
db: uniprot

uniprot Q9JI03 571
type: UnificationXref
id: Q9JI03
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2RA86 127
xref: PTHR24055:SF393
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR24418:SF94
xref: uniprot A0A1D5RJ76 815
organism: Macaca mulatta

Collagen alpha-2(V) chain
type: ProteinReference
xref: uniprot Q3U962 557
xref: PTHR24023:SF539
organism: Mus musculus

Growth factor receptor-bound protein 2
type: ProteinReference
xref: PTHR46037:SF4
xref: uniprot Q60631 192
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR24023:SF918
xref: uniprot F7G4G7 467
organism: Macaca mulatta

PTHR46037:SF2
type: RelationshipXref
id: PTHR46037:SF2
db: PANTHER Family
relationship type: By Homology

uniprot O00750 916
type: UnificationXref
id: O00750
db: uniprot

Vinculin s41 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Vinculin
stoichiometric coefficient: 1.0

Actin, cytoplasmic 2
type: ProteinReference
xref: uniprot P63259 1144
xref: PTHR11937:SF414
organism: Rattus norvegicus

Fibronectin 1a
type: ProteinReference
xref: PTHR19143:SF267
xref: uniprot B0S602 972
organism: Danio rerio

Actin, cytoplasmic 2
type: ProteinReference
xref: uniprot P63258 1143
xref: PTHR11937:SF414
organism: Bos taurus

Laminin-like protein lam-2
type: ProteinReference
xref: uniprot Q18823 1232
xref: PTHR10574:SF79
organism: Caenorhabditis elegans

Dedicator of cytokinesis 1
type: ProteinReference
xref: uniprot H2Q2R7 752
organism: Pan troglodytes

uniprot P50520 934
type: UnificationXref
id: P50520
db: uniprot

Integrin subunit alpha 10
type: ProteinReference
xref: uniprot H2PZU1 1035
xref: PTHR23220:SF26
organism: Pan troglodytes

COL4A6 isoform 8
type: ProteinReference
xref: uniprot A0A2I3RZ64 405
xref: PTHR24023:SF533
organism: Pan troglodytes

uniprot P47941 843
type: UnificationXref
id: P47941
db: uniprot

uniprot P27658 534
type: UnificationXref
id: P27658
db: uniprot

uniprot F7H1M7 469
type: UnificationXref
id: F7H1M7
db: uniprot

Actin, cytoplasmic 2
type: ProteinReference
xref: uniprot P63261 1146
xref: PTHR11937:SF414
organism: Homo sapiens

Actin, cytoplasmic 2
type: ProteinReference
xref: uniprot P63260 1145
xref: PTHR11937:SF414
organism: Mus musculus

uniprot Q803D1 622
type: UnificationXref
id: Q803D1
db: uniprot

Raf
type: ProteinReference
xref: P00924
standard name: Raf Oncogene
comment: ENTITY_REFERENCE_NOTES=Long Name: Raf Synonym: Synonym not specified Accession: P00924
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Raf
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase A-Raf
member entity reference: RAF proto-oncogene serine/threonine-protein kinase
member entity reference: A-Raf proto-oncogene, serine/threonine kinase
member entity reference: Raf-1 proto-oncogene, serine/threonine kinase
member entity reference: Serine/threonine-protein kinase B-raf
member entity reference: B-Raf proto-oncogene, serine/threonine kinase

PTHR44329:SF55
type: RelationshipXref
id: PTHR44329:SF55
db: PANTHER Family
relationship type: By Homology

uniprot D3ZTF6 875
type: UnificationXref
id: D3ZTF6
db: uniprot

Collagen
type: Protein
entity reference: Collagen
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa38 1432
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q95YD4 833
type: UnificationXref
id: Q95YD4
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F7GRP2 259
xref: PTHR24418:SF407
organism: Macaca mulatta

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot F1PT97 209
organism: Canis lupus familiaris

uniprot F7A5M5 1203
type: UnificationXref
id: F7A5M5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XT65 114
xref: PTHR48013:SF5
organism: Monodelphis domestica

uniprot A7EEX6 1251
type: UnificationXref
id: A7EEX6
db: uniprot

Collagen type IX alpha 3 chain
type: ProteinReference
xref: PTHR24023:SF866
xref: uniprot D3ZX71 423
organism: Rattus norvegicus

Beta-parvin
type: ProteinReference
xref: PTHR12114:SF7
xref: uniprot Q9ES46 1169
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r112 1573
type: Stoichiometry
physical entity: GRAF
stoichiometric coefficient: 1.0

uniprot F1MKG2 434
type: UnificationXref
id: F1MKG2
db: uniprot

uniprot Q28DY2 73
type: UnificationXref
id: Q28DY2
db: uniprot

PARTICIPANT STOICHIOMETRY r112 1572
type: Stoichiometry
physical entity: GRAF
stoichiometric coefficient: 1.0

uniprot Q9UGM3 1087
type: UnificationXref
id: Q9UGM3
db: uniprot

ILK
type: Protein
entity reference: ILK
feature: COMPLEX PARTICIPANT BINDING FEATURE s60 sa87 1486
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR44329:SF47
type: RelationshipXref
id: PTHR44329:SF47
db: PANTHER Family
relationship type: By Homology

Rac
type: ProteinReference
xref: P00927
standard name: Ras-related C3 botulinum toxin substrate
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Rac Synonym: Synonym not specified Accession: P00927
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Rac
member entity reference: Ras-related C3 botulinum toxin substrate 1
member entity reference: Uncharacterized protein
member entity reference: Ras-related C3 botulinum toxin substrate 2
member entity reference: Rac family small GTPase 1
member entity reference: GTPase cRac1A
member entity reference: Rho-related protein rac1B
member entity reference: Rho-related protein racC
member entity reference: Ras-related protein Rac1
member entity reference: Rho family GTPase
member entity reference: Rac family small GTPase 3b
member entity reference: Rac family small GTPase 3a
member entity reference: Rho-related protein racB
member entity reference: Rac family small GTPase 1a
member entity reference: Uncharacterized protein racC
member entity reference: Uncharacterized protein rac1A
member entity reference: Rac family small GTPase 1b

Crk-like protein
type: ProteinReference
xref: PTHR19969:SF20
xref: uniprot P46109 842
organism: Homo sapiens

Collagen type VIII alpha 1 chain
type: ProteinReference
xref: uniprot D4AC70 424
xref: PTHR24023:SF903
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR11915:SF434
xref: uniprot F6SUP3 718
organism: Monodelphis domestica

Adapter molecule crk
type: ProteinReference
xref: uniprot P46108 841
xref: PTHR19969:SF8
organism: Homo sapiens

uniprot E9HCC9 357
type: UnificationXref
id: E9HCC9
db: uniprot

ADP-ribosylation factor-like 1
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot Q6DGK1 616
organism: Danio rerio

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A4FV00 1331
organism: Bos taurus

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
type: ProteinReference
xref: uniprot Q1AAU6 183
organism: Rattus norvegicus

Ras-like protein
type: ProteinReference
xref: PTHR24070:SF17
xref: uniprot Q12526 324
organism: Emericella nidulans

uniprot O00459 915
type: UnificationXref
id: O00459
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot F7CYE3 118
organism: Xenopus tropicalis

Rho GTPase activating protein 26
type: ProteinReference
xref: PTHR12552:SF4
xref: uniprot F6TVC2 673
organism: Monodelphis domestica

PTHR10654:SF15
type: RelationshipXref
id: PTHR10654:SF15
db: PANTHER Family
relationship type: By Homology

uniprot F6VTW2 675
type: UnificationXref
id: F6VTW2
db: uniprot

uniprot Q2PDT4 1324
type: UnificationXref
id: Q2PDT4
db: uniprot

PTHR24023:SF714
type: RelationshipXref
id: PTHR24023:SF714
db: PANTHER Family
relationship type: By Homology

ADP ribosylation factor 6
type: ProteinReference
xref: uniprot F6V4X2 360
xref: PTHR11711:SF379
organism: Xenopus tropicalis

Paxillin
type: ProteinReference
xref: uniprot P49023 1322
xref: PTHR24216:SF11
organism: Homo sapiens

Paxillin
type: ProteinReference
xref: uniprot P49024 1323
xref: PTHR24216:SF11
organism: Gallus gallus

uniprot Q8MML5 1326
type: UnificationXref
id: Q8MML5
db: uniprot

Engulfment and cell motility 2, ced-12 homolog (C. elegans), isoform CRA_b
type: ProteinReference
xref: PTHR12771:SF8
xref: uniprot G3V982 340
organism: Rattus norvegicus

uniprot A0A2I3SIY1 867
type: UnificationXref
id: A0A2I3SIY1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24023:SF903
xref: uniprot F6YDU5 453
organism: Monodelphis domestica

PIK3C2A isoform 5
type: ProteinReference
xref: PTHR10048:SF28
xref: uniprot H2Q383 909
organism: Pan troglodytes

Actin stress fibers
type: Pathway

uniprot P55268 1225
type: UnificationXref
id: P55268
db: uniprot

STATE_TRANSITION_LEFT__p130CAS-RIGHT__p130CAS-_r36
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 1564
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 1563
left: p130CAS
interaction type: STATE_TRANSITION
right: p130CAS

Integrin beta (Fragment)
type: ProteinReference
xref: uniprot H3BM21 781
xref: PTHR10082:SF25
organism: Homo sapiens

Actin, beta like 2
type: ProteinReference
xref: uniprot H2QE24 1134
xref: PTHR11937:SF278
organism: Pan troglodytes

uniprot Q99683 161
type: UnificationXref
id: Q99683
db: uniprot

ncbitaxon 227321 325
type: UnificationXref
id: 227321
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F6USY2 112
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r32 1586
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Complex__PIP2_Vinculin_-_VASP-RIGHT__Complex__Vinculin_PIP2__VASP_-_r120
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r120 1542
participant stoichiometry: PARTICIPANT STOICHIOMETRY r120 1543
participant stoichiometry: PARTICIPANT STOICHIOMETRY r120 1544
left: VASP
left: Complex (PIP2/Vinculin)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Vinculin/PIP2/ VASP)

uniprot P15989 525
type: UnificationXref
id: P15989
db: uniprot

PARTICIPANT STOICHIOMETRY r32 1587
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

PTHR44329:SF22
type: RelationshipXref
id: PTHR44329:SF22
db: PANTHER Family
relationship type: By Homology

Integrin beta
type: ProteinReference
xref: PTHR10082:SF26
xref: uniprot H2R828 780
organism: Pan troglodytes

Cdc42
type: ProteinReference
xref: P00938
standard name: Cell division cycle 42
comment: ENTITY_REFERENCE_NOTES=Long Name: Cell division cycle 42 Synonym: Cdc42,Cell division cycle 42 Accession: P00938
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Cdc42
member entity reference: Cdc42 homolog
member entity reference: Cell division control protein 42 homolog
member entity reference: Cdc42 protein, putative
member entity reference: Uncharacterized protein
member entity reference: Cell division cycle 42

Filamin B
type: ProteinReference
xref: PTHR38537:SF7
xref: uniprot A0A0G2JXT8 265
organism: Rattus norvegicus

GTP-binding protein RHO4
type: ProteinReference
xref: PTHR24072:SF290
xref: uniprot Q00246 1285
organism: Saccharomyces cerevisiae

Complex (Grb2/SOS/ FAK)
type: Complex
component stoichiometry: FAK s17 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: Grb2 s15 sa15 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS s16 sa16 STOICHIOMETRY ID COMPLEX
component: Grb2
component: SOS
component: FAK
feature: COMPLEX BINDING FEATURE s188 a255 1439
feature: COMPLEX BINDING FEATURE s188 a255 1437
feature: COMPLEX BINDING FEATURE s188 a255 1441
cellular location: cytoplasm

Integrin beta pat-3
type: ProteinReference
xref: uniprot Q27874 803
xref: PTHR10082:SF41
organism: Caenorhabditis elegans

Parvin s62 sa89 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Parvin
stoichiometric coefficient: 1.0

MODULATION
type: Control
xref: MODULATION
controlled: Actin polymerization
controller: Complex (Vinculin/PIP2/ Arp2/3)

uniprot Q05876 1100
type: UnificationXref
id: Q05876
db: uniprot

uniprot Q64739 562
type: UnificationXref
id: Q64739
db: uniprot

PARTICIPANT STOICHIOMETRY r119 1554
type: Stoichiometry
physical entity: Complex (PIP2/Vinculin)
stoichiometric coefficient: 1.0

uniprot Q6ZQ82 681
type: UnificationXref
id: Q6ZQ82
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot E9GYE9 963
organism: Daphnia pulex

PARTICIPANT STOICHIOMETRY r119 1555
type: Stoichiometry
physical entity: Arp2/3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r119 1556
type: Stoichiometry
physical entity: Complex (Vinculin/PIP2/ Arp2/3)
stoichiometric coefficient: 1.0

uniprot O15264 132
type: UnificationXref
id: O15264
db: uniprot

uniprot Q70UZ7 565
type: UnificationXref
id: Q70UZ7
db: uniprot

Collagen s7 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Collagen
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__p130CAS-RIGHT__p130CAS-_r13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 1532
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 1531
left: p130CAS
interaction type: STATE_TRANSITION
right: p130CAS

Phosphoinositide-3-kinase regulatory subunit 1
type: ProteinReference
xref: uniprot F6Z0J4 896
xref: PTHR10155:SF3
organism: Xenopus tropicalis

Rac family small GTPase 1b
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q29RC5 699
organism: Danio rerio

uniprot H2QTA4 482
type: UnificationXref
id: H2QTA4
db: uniprot

Beta-actin-like protein 2
type: ProteinReference
xref: uniprot Q8BFZ3 1158
xref: PTHR11937:SF168
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF194
xref: uniprot F7DGX0 45
organism: Monodelphis domestica

Deleted in malignant brain tumors 1 protein
type: ProteinReference
xref: uniprot Q9UGM3 1087
xref: PTHR19331:SF22
organism: Homo sapiens

Ras-like GTP-binding protein rhoA
type: ProteinReference
xref: uniprot Q22038 1288
xref: PTHR24072:SF168
organism: Caenorhabditis elegans

uniprot E9Q6R1 1013
type: UnificationXref
id: E9Q6R1
db: uniprot

uniprot O96626 231
type: UnificationXref
id: O96626
db: uniprot

Integrin beta
type: Protein
entity reference: Integrin beta
feature: ACTIVE 89
feature: COMPLEX PARTICIPANT BINDING FEATURE s63 sa69 1452
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F1MYM3 885
type: UnificationXref
id: F1MYM3
db: uniprot

uniprot P27986 927
type: UnificationXref
id: P27986
db: uniprot

uniprot E9PT20 1173
type: UnificationXref
id: E9PT20
db: uniprot

uniprot F1MUP6 1260
type: UnificationXref
id: F1MUP6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r111
controller: MEK

uniprot P42337 930
type: UnificationXref
id: P42337
db: uniprot

uniprot P63260 1145
type: UnificationXref
id: P63260
db: uniprot

uniprot Q9QZR9 575
type: UnificationXref
id: Q9QZR9
db: uniprot

Dock180
type: Protein
entity reference: Dock180
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

MEK
type: Protein
entity reference: MEK
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7AGY1 459
type: UnificationXref
id: F7AGY1
db: uniprot

uniprot Q05722 550
type: UnificationXref
id: Q05722
db: uniprot

Caveolin
type: ProteinReference
xref: uniprot F7FDW7 348
xref: PTHR10844:SF18
organism: Monodelphis domestica

ncbitaxon 214684 314
type: UnificationXref
id: 214684
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR23220:SF4
xref: uniprot A0A1D5RJA5 998
organism: Macaca mulatta

uniprot Q91Y86 1348
type: UnificationXref
id: Q91Y86
db: uniprot

p130CAS
type: Protein
entity reference: p130CAS
feature: COMPLEX PARTICIPANT BINDING FEATURE s78 sa90 1382
feature: p130CAS s78 sa90 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PI3K-RIGHT__PIP2-_r32
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 1587
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 1586
left: PI3K
interaction type: STATE_TRANSITION
right: PIP2

Phosphatidylinositol 3-kinase VPS34
type: ProteinReference
xref: uniprot P22543 923
xref: PTHR10048:SF7
organism: Saccharomyces cerevisiae

Integrin beta-5
type: ProteinReference
xref: PTHR10082:SF26
xref: uniprot P18084 793
organism: Homo sapiens

uniprot K7BYT0 659
type: UnificationXref
id: K7BYT0
db: uniprot

Laminin subunit alpha
type: ProteinReference
xref: PTHR10574:SF406
xref: uniprot Q00174 1227
organism: Drosophila melanogaster

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 13

ncbitaxon 9606 59
type: UnificationXref
id: 9606
db: ncbitaxon

Collagen alpha-2(V) chain
type: ProteinReference
xref: uniprot P05997 510
xref: PTHR24023:SF539
organism: Homo sapiens

uniprot P60709 1138
type: UnificationXref
id: P60709
db: uniprot

uniprot P32017 537
type: UnificationXref
id: P32017
db: uniprot

ASAP1
type: ProteinReference
xref: P00909
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: ASAP1 Synonym: Synonym not specified Accession: P00909
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.ASAP1
member entity reference: ADP-ribosylation factor GTPase-activating protein 1
member entity reference: ADP ribosylation factor GTPase activating protein 1
member entity reference: ASAP1 isoform 2
member entity reference: Uncharacterized protein
member entity reference: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

Engulfment and cell motility protein 2
type: ProteinReference
xref: PTHR12771:SF8
xref: uniprot A4FUD6 334
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR24023:SF980
xref: uniprot F6ZKG7 456
organism: Macaca mulatta

Protein ras-1
type: ProteinReference
xref: PTHR24070:SF17
xref: uniprot P22126 318
organism: Neurospora crassa

uniprot B1AVK5 419
type: UnificationXref
id: B1AVK5
db: uniprot

uniprot Q7TPR4 739
type: UnificationXref
id: Q7TPR4
db: uniprot

Evidence 194
type: Evidence
evidence code: ISS
comment: Website http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd

uniprot P10301 315
type: UnificationXref
id: P10301
db: uniprot

Crk-like protein
type: ProteinReference
xref: uniprot Q5U2U2 844
xref: PTHR19969:SF20
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION_LEFT__PIP2-_Vinculin-RIGHT__Complex__PIP2_Vinculin_-_r57
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 1613
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 1614
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 1612
left: Vinculin
left: PIP2
interaction type: HETERODIMER_ASSOCIATION
right: Complex (PIP2/Vinculin)

Talin s67 sa73 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Talin
stoichiometric coefficient: 1.0

uniprot Q5BJ82 615
type: UnificationXref
id: Q5BJ82
db: uniprot

Related RAS viral (R-ras) oncogene homolog
type: ProteinReference
xref: PTHR24070:SF245
xref: uniprot Q2TBH2 327
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6ZKB3 1337
xref: PTHR24055:SF222
organism: Macaca mulatta

uniprot F7ALP1 1131
type: UnificationXref
id: F7ALP1
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7G3I5 903
xref: PTHR10048:SF107
organism: Monodelphis domestica

uniprot Q60677 1076
type: UnificationXref
id: Q60677
db: uniprot

SHC (Src homology 2 domain containing) transforming protein 1
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot H2R8L2 1314
organism: Pan troglodytes

uniprot F7GXP0 392
type: UnificationXref
id: F7GXP0
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6WV79 1335
xref: PTHR24055:SF172
organism: Monodelphis domestica

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot A0A3Q1M353 197
xref: PTHR44329:SF47
organism: Bos taurus

uniprot G5ECE3 1206
type: UnificationXref
id: G5ECE3
db: uniprot

Small ARF-related GTPase
type: ProteinReference
xref: uniprot A8IL29 585
xref: PTHR11711:SF30
organism: Chlamydomonas reinhardtii

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FE47 466
xref: PTHR24023:SF372
organism: Macaca mulatta

Protein CBR-LET-60
type: ProteinReference
xref: uniprot A8X0X5 288
xref: PTHR24070:SF420
organism: Caenorhabditis briggsae

uniprot Q1HG70 667
type: UnificationXref
id: Q1HG70
db: uniprot

Integrin beta-4
type: ProteinReference
xref: PTHR10082:SF42
xref: uniprot P16144 792
organism: Homo sapiens

uniprot A7SEA7 1116
type: UnificationXref
id: A7SEA7
db: uniprot

RHOA isoform 2
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot H2QML4 1269
organism: Pan troglodytes

uniprot P20701 1059
type: UnificationXref
id: P20701
db: uniprot

Collagen alpha-1(X) chain
type: ProteinReference
xref: uniprot F1NRH2 439
xref: PTHR24023:SF880
organism: Gallus gallus

Focal adhesion kinase 1
type: ProteinReference
xref: uniprot Q00944 830
xref: PTHR24418:SF78
organism: Gallus gallus

Collagen type V alpha 1 chain
type: ProteinReference
xref: uniprot F6ZCA5 455
xref: PTHR24023:SF387
organism: Ornithorhynchus anatinus

uniprot P91634 938
type: UnificationXref
id: P91634
db: uniprot

uniprot F6ZXR6 457
type: UnificationXref
id: F6ZXR6
db: uniprot

uniprot A0A2I3SDP5 1320
type: UnificationXref
id: A0A2I3SDP5
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 618

uniprot F6TD14 891
type: UnificationXref
id: F6TD14
db: uniprot

uniprot Q9Z1B7 168
type: UnificationXref
id: Q9Z1B7
db: uniprot

Ras-related protein Rap-2a
type: ProteinReference
xref: PTHR24070:SF221
xref: uniprot Q80ZJ1 83
organism: Mus musculus

Actin beta
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot F6UDX9 1128
organism: Ornithorhynchus anatinus

RhoA protein
type: ProteinReference
xref: uniprot A7EEX6 1251
xref: PTHR24072:SF168
organism: Sclerotinia sclerotiorum

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P21708 134
organism: Rattus norvegicus

Laminin subunit beta 2
type: ProteinReference
xref: PTHR10574:SF36
xref: uniprot H2QMK9 1210
organism: Pan troglodytes

uniprot Q99N57 642
type: UnificationXref
id: Q99N57
db: uniprot

Complex ILK PINCH Parvin s373 a552 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (ILK/PINCH/ Parvin)
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot P47809 666
xref: PTHR48013:SF15
organism: Mus musculus

Integrin alpha-10
type: ProteinReference
xref: PTHR23220:SF26
xref: uniprot O75578 1048
organism: Homo sapiens

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
type: ProteinReference
xref: uniprot O00750 916
xref: PTHR10048:SF30
organism: Homo sapiens

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF0
xref: uniprot F7FN72 217
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY re61 1627
type: Stoichiometry
physical entity: Src
stoichiometric coefficient: 1.0

uniprot A4IFU2 9
type: UnificationXref
id: A4IFU2
db: uniprot

PARTICIPANT STOICHIOMETRY re61 1628
type: Stoichiometry
physical entity: Src
stoichiometric coefficient: 1.0

Danio rerio
type: BioSource
xref: ncbitaxon 7955 16

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q7K7 1113
xref: PTHR11937:SF414
organism: Macaca mulatta

Protein tyrosine kinase 2
type: ProteinReference
xref: PTHR24418:SF78
xref: uniprot E2RGQ1 822
organism: Canis lupus familiaris

uniprot P04627 636
type: UnificationXref
id: P04627
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot A0A2I3SKP4 1091
organism: Pan troglodytes

Collagen s75 sa81 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Collagen
stoichiometric coefficient: 1.0

uniprot E1BI98 427
type: UnificationXref
id: E1BI98
db: uniprot

Rap1
type: Protein
entity reference: Rap1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P61212 608
type: UnificationXref
id: P61212
db: uniprot

Integrin alpha
type: Protein
entity reference: Integrin alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s64 sa70 1454
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Collagen alpha-1(XIV) chain
type: ProteinReference
xref: uniprot A0A1D5P0F4 400
xref: PTHR24020:SF15
organism: Gallus gallus

Actin
type: ProteinReference
xref: P00944
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Actin
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Beta-actin-like protein 2
member entity reference: Actin, alpha skeletal muscle
member entity reference: Actin, cytoplasmic 2
member entity reference: Actin beta
member entity reference: Actin, cytoplasmic 1
member entity reference: Actin, gamma-enteric smooth muscle
member entity reference: Uncharacterized protein
member entity reference: Actin
member entity reference: Actin, beta like 2
member entity reference: Actin, cytoplasmic type 5
member entity reference: Predicted protein
member entity reference: Actin, alpha cardiac muscle 1
member entity reference: Actin, aortic smooth muscle
member entity reference: Putative actin-22
member entity reference: Actin, beta-like 2
member entity reference: ACTin

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot D4A5Q1 877
organism: Rattus norvegicus

ITGA9 isoform 2
type: ProteinReference
xref: uniprot H2QMA4 1042
xref: PTHR23220:SF69
organism: Pan troglodytes

Talin
type: Protein
entity reference: Talin
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q8N3F8 740
type: UnificationXref
id: Q8N3F8
db: uniprot

uniprot H2QKS2 178
type: UnificationXref
id: H2QKS2
db: uniprot

PTHR22588:SF5
type: RelationshipXref
id: PTHR22588:SF5
db: PANTHER Family
relationship type: By Homology

Vasodilator-stimulated phosphoprotein
type: ProteinReference
xref: PTHR11202:SF12
xref: uniprot P50551 849
organism: Canis lupus familiaris

PTHR24072:SF0
type: RelationshipXref
id: PTHR24072:SF0
db: PANTHER Family
relationship type: By Homology

GTP-binding protein RHO4
type: ProteinReference
xref: PTHR24072:SF290
xref: uniprot Q9P8V0 1308
organism: Ashbya gossypii

Vasodilator-stimulated phosphoprotein
type: ProteinReference
xref: uniprot P50552 850
xref: PTHR11202:SF12
organism: Homo sapiens

uniprot A0A0G2K9C0 847
type: UnificationXref
id: A0A0G2K9C0
db: uniprot

uniprot P36506 662
type: UnificationXref
id: P36506
db: uniprot

GTP-binding protein rho1
type: ProteinReference
xref: uniprot Q09914 1286
xref: PTHR24072:SF168
organism: Schizosaccharomyces pombe

uniprot C4M5Q7 685
type: UnificationXref
id: C4M5Q7
db: uniprot

Alpha-actinin-1
type: ProteinReference
xref: PTHR23167:SF32
xref: uniprot Q3B7N2 737
organism: Bos taurus

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: uniprot P15056 198
xref: PTHR44329:SF47
organism: Homo sapiens

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot O18840 1135
organism: Canis lupus familiaris

uniprot H2QFS6 910
type: UnificationXref
id: H2QFS6
db: uniprot

Integrin, alpha 10
type: ProteinReference
xref: uniprot E9Q6R1 1013
xref: PTHR23220:SF26
organism: Mus musculus

uniprot B8JK39 1005
type: UnificationXref
id: B8JK39
db: uniprot

uniprot A0A3Q1MLQ7 1104
type: UnificationXref
id: A0A3Q1MLQ7
db: uniprot

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F6PXH5 653
organism: Ornithorhynchus anatinus

Grb2
type: Protein
entity reference: Grb2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7HPR8 1313
type: UnificationXref
id: F7HPR8
db: uniprot

uniprot P63086 143
type: UnificationXref
id: P63086
db: uniprot

uniprot P01111 305
type: UnificationXref
id: P01111
db: uniprot

uniprot Q9CVB6 248
type: UnificationXref
id: Q9CVB6
db: uniprot

Ras-like protein rasG
type: ProteinReference
xref: PTHR24070:SF17
xref: uniprot P15064 317
organism: Dictyostelium discoideum

Fibronectin
type: Protein
entity reference: Fibronectin
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa7 1366
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

von Willebrand factor A domain-containing protein 2
type: ProteinReference
xref: uniprot Q70UZ7 565
organism: Mus musculus

Stress-activated protein kinase JNK
type: ProteinReference
xref: PTHR24055:SF341
xref: uniprot P92208 1345
organism: Drosophila melanogaster

uniprot F7E9T7 839
type: UnificationXref
id: F7E9T7
db: uniprot

ILK
type: Protein
entity reference: ILK
feature: COMPLEX PARTICIPANT BINDING FEATURE s374 sa84 1444
feature: ACTIVE 89
comment: SPECIES_TYPE=PROTEIN

SOS s16 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

uniprot F7GJZ7 258
type: UnificationXref
id: F7GJZ7
db: uniprot

uniprot A6QLK6 189
type: UnificationXref
id: A6QLK6
db: uniprot

PTHR10048:SF64
type: RelationshipXref
id: PTHR10048:SF64
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF430
xref: uniprot A8Y1X2 981
organism: Caenorhabditis briggsae

ncbitaxon 9598 4
type: UnificationXref
id: 9598
db: ncbitaxon

RAP2C, member of RAS oncogene family
type: ProteinReference
xref: PTHR24070:SF200
xref: uniprot Q28DY2 73
organism: Xenopus tropicalis

uniprot P54674 936
type: UnificationXref
id: P54674
db: uniprot

Rho-related GTP-binding protein RhoE
type: ProteinReference
xref: PTHR24072:SF24
xref: uniprot F7FMR3 1266
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR23220:SF9
xref: uniprot F7GNU4 1030
organism: Macaca mulatta

uniprot E2QTG4 821
type: UnificationXref
id: E2QTG4
db: uniprot

uniprot F6RFW8 1126
type: UnificationXref
id: F6RFW8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Z0X3 1027
xref: PTHR23220:SF78
organism: Macaca mulatta

PTP-PEST
type: Protein
entity reference: PTP-PEST
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot H2QMK9 1210
type: UnificationXref
id: H2QMK9
db: uniprot

PTHR11937:SF477
type: RelationshipXref
id: PTHR11937:SF477
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF473
type: RelationshipXref
id: PTHR11937:SF473
db: PANTHER Family
relationship type: By Homology

uniprot Q9HBI1 1171
type: UnificationXref
id: Q9HBI1
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F6UTP2 257
xref: PTHR24418:SF407
organism: Xenopus tropicalis

uniprot F7AKA6 116
type: UnificationXref
id: F7AKA6
db: uniprot

uniprot Q8VDV0 812
type: UnificationXref
id: Q8VDV0
db: uniprot

p130CAS
type: ProteinReference
xref: P00908
standard name: p130 Crk-associated substrate
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.p130CAS
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: p130 Crk-associated substrate Synonym: CAS,p130 Crk-associated substrate,p130CAS Accession: P00908
member entity reference: BCAR1 isoform 5
member entity reference: Breast cancer anti-estrogen resistance protein 1
member entity reference: BCAR1, Cas family scaffold protein

uniprot F6YN59 750
type: UnificationXref
id: F6YN59
db: uniprot

Integrin alpha-2
type: ProteinReference
xref: PTHR23220:SF23
xref: uniprot P17301 1057
organism: Homo sapiens

Integrin beta-1
type: ProteinReference
xref: PTHR10082:SF28
xref: uniprot P07228 788
organism: Gallus gallus

PTHR10048:SF34
type: RelationshipXref
id: PTHR10048:SF34
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF33
type: RelationshipXref
id: PTHR10048:SF33
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF35
type: RelationshipXref
id: PTHR10048:SF35
db: PANTHER Family
relationship type: By Homology

LIM and senescent cell antigen-like-containing domain protein
type: ProteinReference
xref: uniprot F7AFB2 391
xref: PTHR24210:SF10
organism: Monodelphis domestica

FAK s66 sa72 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.647709131634312
comment: MODIFICATION_RESIDUE_NAME=

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot F7HLC7 905
organism: Macaca mulatta

LIM and senescent cell antigen-like-containing domain protein
type: ProteinReference
xref: uniprot C0KUC6 388
xref: PTHR24210:SF11
organism: Rattus norvegicus

ncbitaxon 9615 24
type: UnificationXref
id: 9615
db: ncbitaxon

BCAR1 isoform 5
type: ProteinReference
xref: PTHR10654:SF15
xref: uniprot A0A2I3SRL3 169
organism: Pan troglodytes

Protein tyrosine kinase 2
type: ProteinReference
xref: uniprot A0A2I3T3L8 816
xref: PTHR24418:SF78
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RH85 880
xref: PTHR10155:SF1
organism: Canis lupus familiaris

uniprot F7FE47 466
type: UnificationXref
id: F7FE47
db: uniprot

uniprot F7A1D4 41
type: UnificationXref
id: F7A1D4
db: uniprot

Integrin beta
type: ProteinReference
xref: PTHR10082:SF11
xref: uniprot A0A2I3SC11 758
organism: Pan troglodytes

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot A0A3Q1LQK4 871
organism: Bos taurus

Rho
type: ProteinReference
xref: P00948
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Rho
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Rho Synonym: Synonym not specified Accession: P00948
member entity reference: Uncharacterized protein
member entity reference: Rho-related GTP-binding protein RhoC
member entity reference: Ras homolog family member C
member entity reference: Rho family GTPase 3
member entity reference: Rho-related GTP-binding protein RhoE
member entity reference: GTP-binding protein RHO1
member entity reference: Ras-like GTP-binding protein rhoA
member entity reference: Rho family GTPase 1
member entity reference: Novel Rho protein
member entity reference: Ras homolog family member B
member entity reference: Rho-related GTP-binding protein RhoA-B
member entity reference: GTP-binding protein RHO4
member entity reference: Rho-related GTP-binding protein Rho6
member entity reference: RHOA isoform 2
member entity reference: Rho family GTPase 2
member entity reference: Rho-related GTP-binding protein RhoN
member entity reference: GTP-binding protein
member entity reference: RND3 protein
member entity reference: Predicted protein
member entity reference: Ras-like GTP-binding protein Rho1
member entity reference: Rho family GTPase 3a
member entity reference: GTP-binding protein rho1
member entity reference: Rho-related GTP-binding protein RhoB
member entity reference: RhoA protein
member entity reference: Ras homolog family member A
member entity reference: RND3 isoform 1
member entity reference: GTP-binding protein rhoA
member entity reference: Protein CBR-RHO-1
member entity reference: Transforming protein RhoA
member entity reference: Rho-related GTP-binding protein RhoA-A
member entity reference: GTP-binding protein rho5

LAMA3 isoform 1
type: ProteinReference
xref: PTHR10574:SF285
xref: uniprot H2QEC7 1209
organism: Pan troglodytes

Integrin alpha-4
type: ProteinReference
xref: uniprot P13612 1056
xref: PTHR23220:SF78
organism: Homo sapiens

FAK s66 sa72 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.851793120491741

PIP2
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s88 sa97 1504
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F6XER9 838
type: UnificationXref
id: F6XER9
db: uniprot

PTHR10048:SF48
type: RelationshipXref
id: PTHR10048:SF48
db: PANTHER Family
relationship type: By Homology

uniprot Q95ME4 331
type: UnificationXref
id: Q95ME4
db: uniprot

ACTN2 isoform 3
type: ProteinReference
xref: uniprot A0A2I3S2J2 707
xref: PTHR11915:SF429
organism: Pan troglodytes

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 28

uniprot A5D7D1 710
type: UnificationXref
id: A5D7D1
db: uniprot

Crk
type: Protein
entity reference: Crk
feature: COMPLEX PARTICIPANT BINDING FEATURE s79 sa91 1384
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P08134 1275
type: UnificationXref
id: P08134
db: uniprot

Vasodilator-stimulated phosphoprotein
type: ProteinReference
xref: uniprot A0A0G2K9C0 847
xref: PTHR11202:SF12
organism: Rattus norvegicus

-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot Q503B6 328
organism: Danio rerio

uniprot Q6NUX8 1298
type: UnificationXref
id: Q6NUX8
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: PTHR12644:SF3
xref: uniprot O61861 229
organism: Caenorhabditis elegans

PTHR10048:SF14
type: RelationshipXref
id: PTHR10048:SF14
db: PANTHER Family
relationship type: By Homology

uniprot E9I1I7 292
type: UnificationXref
id: E9I1I7
db: uniprot

PARTICIPANT STOICHIOMETRY r105 1609
type: Stoichiometry
physical entity: B-Raf
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r105 1608
type: Stoichiometry
physical entity: B-Raf
stoichiometric coefficient: 1.0

VASP
type: Protein
entity reference: VASP
feature: COMPLEX PARTICIPANT BINDING FEATURE s92 sa101 1372
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P13942 522
type: UnificationXref
id: P13942
db: uniprot

uniprot Q0VBZ0 264
type: UnificationXref
id: Q0VBZ0
db: uniprot

uniprot Q6IMM1 79
type: UnificationXref
id: Q6IMM1
db: uniprot

PTHR19143:SF267
type: RelationshipXref
id: PTHR19143:SF267
db: PANTHER Family
relationship type: By Homology

uniprot Q61087 1237
type: UnificationXref
id: Q61087
db: uniprot

Collagen s55 sa61 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Collagen
stoichiometric coefficient: 1.0

uniprot H2QXW1 222
type: UnificationXref
id: H2QXW1
db: uniprot

uniprot G2HIU2 601
type: UnificationXref
id: G2HIU2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QWF4 175
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MXH6 105
organism: Bos taurus

cytoplasm
type: CellularLocationVocabulary
xref: GO GO:0005737 2

Uncharacterized protein
type: ProteinReference
xref: PTHR10574:SF270
xref: uniprot F6WVB2 1200
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF24
xref: uniprot F6RYV4 1262
organism: Monodelphis domestica

PTHR10048:SF29
type: RelationshipXref
id: PTHR10048:SF29
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF28
type: RelationshipXref
id: PTHR10048:SF28
db: PANTHER Family
relationship type: By Homology

uniprot E2RLH2 1257
type: UnificationXref
id: E2RLH2
db: uniprot

STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r89
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r89 1615
participant stoichiometry: PARTICIPANT STOICHIOMETRY r89 1616
left: Ras
interaction type: STATE_TRANSITION
right: Ras

PTHR24216:SF11
type: RelationshipXref
id: PTHR24216:SF11
db: PANTHER Family
relationship type: By Homology

Jnk
type: Protein
entity reference: Jnk
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Collagen type VIII alpha 2 chain
type: ProteinReference
xref: PTHR24023:SF1027
xref: uniprot H2PZI4 474
organism: Pan troglodytes

PTHR10048:SF30
type: RelationshipXref
id: PTHR10048:SF30
db: PANTHER Family
relationship type: By Homology

uniprot Q9Z1L0 954
type: UnificationXref
id: Q9Z1L0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FRN8 855
organism: Monodelphis domestica

uniprot A0A2R8RR02 817
type: UnificationXref
id: A0A2R8RR02
db: uniprot

Filamin s37 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Filamin
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F7GLY8 657
organism: Macaca mulatta

uniprot P04937 977
type: UnificationXref
id: P04937
db: uniprot

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF1
xref: uniprot Q3T035 237
organism: Bos taurus

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot P23726 924
organism: Bos taurus

ADP-ribosylation factor 1
type: ProteinReference
xref: PTHR11711:SF357
xref: uniprot G2HIU2 601
organism: Pan troglodytes

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P23727 925
organism: Bos taurus

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot Q63932 668
organism: Mus musculus

Laminin subunit beta-1
type: ProteinReference
xref: PTHR10574:SF233
xref: uniprot P07942 1218
organism: Homo sapiens

Caveolin
type: Protein
entity reference: Caveolin
feature: COMPLEX PARTICIPANT BINDING FEATURE s47 sa58 1396
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q61292 1239
type: UnificationXref
id: Q61292
db: uniprot

uniprot F6Y4G8 1336
type: UnificationXref
id: F6Y4G8
db: uniprot

uniprot A0A3Q1LSJ2 96
type: UnificationXref
id: A0A3Q1LSJ2
db: uniprot

LIM domain-containing protein
type: ProteinReference
xref: uniprot F6UCA3 390
organism: Xenopus tropicalis

uniprot E2REI6 630
type: UnificationXref
id: E2REI6
db: uniprot

uniprot F7G3I5 903
type: UnificationXref
id: F7G3I5
db: uniprot

uniprot F1PR66 1198
type: UnificationXref
id: F1PR66
db: uniprot

uniprot Q5ZL97 343
type: UnificationXref
id: Q5ZL97
db: uniprot

Integrin alpha-V
type: ProteinReference
xref: PTHR23220:SF4
xref: uniprot P43406 1067
organism: Mus musculus

Parvin
type: Protein
entity reference: Parvin
feature: COMPLEX PARTICIPANT BINDING FEATURE s376 sa86 1448
comment: SPECIES_TYPE=PROTEIN

uniprot G3V7M2 778
type: UnificationXref
id: G3V7M2
db: uniprot

Laminin subunit alpha-3
type: ProteinReference
xref: PTHR10574:SF285
xref: uniprot Q16787 1231
organism: Homo sapiens

STATE_TRANSITION_LEFT__Src-RIGHT__Src-_re61
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re61 1627
participant stoichiometry: PARTICIPANT STOICHIOMETRY re61 1628
left: Src
interaction type: STATE_TRANSITION
right: Src

uniprot Q8WQM5 992
type: UnificationXref
id: Q8WQM5
db: uniprot

Phosphatidylinositol 3-kinase age-1
type: ProteinReference
xref: uniprot Q94125 951
xref: PTHR10048:SF14
organism: Caenorhabditis elegans

uniprot D3ZMQ3 1007
type: UnificationXref
id: D3ZMQ3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE TRANSITION LEFT Complex Integrin beta Integrin alpha Paxillin FAK Talin Vinculin Actin Integrin alpha alpha actinin Actin Integrin beta Filamin Collagen Laminin Fibronectin -RIGHT FAK- r76
controller: FAK

Integrin beta
type: ProteinReference
xref: PTHR10082:SF15
xref: uniprot F6QYS6 772
organism: Macaca mulatta

uniprot P36579 604
type: UnificationXref
id: P36579
db: uniprot

FLNB isoform 8
type: ProteinReference
xref: PTHR38537:SF7
xref: uniprot K7CD41 273
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r94 1592
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r94 1593
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

SOS
type: Protein
entity reference: SOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa16 1440
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot Q3ZC07 1148
organism: Bos taurus

uniprot F1M9D0 103
type: UnificationXref
id: F1M9D0
db: uniprot

uniprot Q6DGB7 700
type: UnificationXref
id: Q6DGB7
db: uniprot

Integrin alpha-PS3
type: ProteinReference
xref: uniprot O44386 1047
xref: PTHR23220:SF123
organism: Drosophila melanogaster

uniprot F1MAN8 1196
type: UnificationXref
id: F1MAN8
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot A8WWE8 203
xref: PTHR12644:SF3
organism: Caenorhabditis briggsae

uniprot F6PP96 445
type: UnificationXref
id: F6PP96
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__B_Raf-RIGHT__B_Raf-_r105
controller: Rap1

Collagen type VIII alpha 2 chain
type: ProteinReference
xref: PTHR24023:SF1027
xref: uniprot D4ADG9 425
organism: Rattus norvegicus

uniprot Q63788 940
type: UnificationXref
id: Q63788
db: uniprot

Focal adhesion kinase 1
type: ProteinReference
xref: PTHR24418:SF78
xref: uniprot Q05397 831
organism: Homo sapiens

uniprot P17301 1057
type: UnificationXref
id: P17301
db: uniprot

uniprot Q61532 155
type: UnificationXref
id: Q61532
db: uniprot

Tyrosine-protein kinase fynb
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot F1RDG9 1094
organism: Danio rerio

uniprot A2ACT7 414
type: UnificationXref
id: A2ACT7
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot Q61831 1346
xref: PTHR24055:SF162
organism: Mus musculus

p130CAS s78 sa90 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.9229354047838125
comment: MODIFICATION_RESIDUE_NAME=

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Shc-RIGHT__Shc-_r48
controller: Fyn

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DIB7 1132
xref: PTHR11937:SF414
organism: Monodelphis domestica

uniprot P02463 505
type: UnificationXref
id: P02463
db: uniprot

Collagen, type I, alpha 2
type: ProteinReference
xref: PTHR24023:SF568
xref: uniprot Q6IQX2 563
organism: Danio rerio

uniprot C4M5Z7 687
type: UnificationXref
id: C4M5Z7
db: uniprot

uniprot P05107 786
type: UnificationXref
id: P05107
db: uniprot

uniprot O75369 274
type: UnificationXref
id: O75369
db: uniprot

uniprot P53708 541
type: UnificationXref
id: P53708
db: uniprot

Laminin subunit beta 4
type: ProteinReference
xref: PTHR10574:SF279
xref: uniprot H2QV85 1211
organism: Pan troglodytes

uniprot F1PZ23 278
type: UnificationXref
id: F1PZ23
db: uniprot

uniprot A0A1D5R9U8 623
type: UnificationXref
id: A0A1D5R9U8
db: uniprot

uniprot F7FDW7 348
type: UnificationXref
id: F7FDW7
db: uniprot

uniprot O43707 727
type: UnificationXref
id: O43707
db: uniprot

PTHR46180:SF1
type: RelationshipXref
id: PTHR46180:SF1
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RI38 583
xref: PTHR11711:SF357
organism: Macaca mulatta

ncbitaxon 10090 66
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot P02452 498
type: UnificationXref
id: P02452
db: uniprot

Actin
type: Protein
entity reference: Actin
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa42 1376
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P08556 310
type: UnificationXref
id: P08556
db: uniprot

STATE_TRANSITION_LEFT__ASAP1-RIGHT__ASAP1-_r116
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r116 1562
participant stoichiometry: PARTICIPANT STOICHIOMETRY r116 1561
left: ASAP1
interaction type: STATE_TRANSITION
right: ASAP1

uniprot P32592 798
type: UnificationXref
id: P32592
db: uniprot

AGAP011036-PA (Fragment)
type: ProteinReference
xref: uniprot A0NBA9 873
xref: PTHR10048:SF64
organism: Anopheles gambiae

uniprot A0A3Q1LPF2 95
type: UnificationXref
id: A0A3Q1LPF2
db: uniprot

uniprot P32871 928
type: UnificationXref
id: P32871
db: uniprot

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot A0A3Q1LSJ2 96
organism: Bos taurus

Collagen s38 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Collagen
stoichiometric coefficient: 1.0

uniprot P53710 1068
type: UnificationXref
id: P53710
db: uniprot

Integrin-linked protein kinase
type: ProteinReference
xref: uniprot Q3SWY2 858
organism: Bos taurus

Raf
type: Protein
entity reference: Raf
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Rho-related GTP-binding protein RhoN
type: ProteinReference
xref: PTHR24072:SF21
xref: uniprot Q9QYM5 1311
organism: Mus musculus

STATE_TRANSITION_LEFT__Jnk-RIGHT__Jnk-_r103
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r103 1618
participant stoichiometry: PARTICIPANT STOICHIOMETRY r103 1617
left: Jnk
interaction type: STATE_TRANSITION
right: Jnk

PTP-PEST
type: ProteinReference
xref: P00915
standard name: Protein tyrosine phosphatase-PEST
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.PTP-PEST
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein tyrosine phosphatase-PEST Synonym: PTP-PEST,Protein tyrosin phosphatase-PEST Accession: P00915
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Tyrosine-protein phosphatase non-receptor type 12

Actin-related protein 2/3 complex subunit 1A
type: ProteinReference
xref: uniprot Q1JP79 234
xref: PTHR10709:SF11
organism: Bos taurus

uniprot P26010 795
type: UnificationXref
id: P26010
db: uniprot

uniprot F6UTP2 257
type: UnificationXref
id: F6UTP2
db: uniprot

uniprot F7HLC7 905
type: UnificationXref
id: F7HLC7
db: uniprot

uniprot F6SY88 599
type: UnificationXref
id: F6SY88
db: uniprot

Integrin subunit alpha 10
type: ProteinReference
xref: uniprot D3ZW82 1010
xref: PTHR23220:SF26
organism: Rattus norvegicus

uniprot A5A6J7 10
type: UnificationXref
id: A5A6J7
db: uniprot

Alpha-actinin-2
type: ProteinReference
xref: PTHR11915:SF429
xref: uniprot Q3ZC55 738
organism: Bos taurus

COL14A1 isoform 4
type: ProteinReference
xref: uniprot A0A2I3S4E5 406
xref: PTHR24020:SF15
organism: Pan troglodytes

uniprot E2QY08 715
type: UnificationXref
id: E2QY08
db: uniprot

MAP2K2 isoform 1
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot K7BYT0 659
organism: Pan troglodytes

GRB2-related adapter protein
type: ProteinReference
xref: PTHR46037:SF2
xref: uniprot Q9CX99 195
organism: Mus musculus

Complex (PIP2/Vinculin)
type: Complex
component stoichiometry: Vinculin s59 sa68 STOICHIOMETRY ID COMPLEX
component stoichiometry: PIP2 s58 sa67 STOICHIOMETRY ID COMPLEX
component: PIP2
component: Vinculin
feature: COMPLEX BINDING FEATURE s308 a466 1407
feature: COMPLEX BINDING FEATURE s308 a466 1409
cellular location: cytoplasm

PIK3R1 isoform 1
type: ProteinReference
xref: uniprot A0A2I3SIY1 867
xref: PTHR10155:SF3
organism: Pan troglodytes

PTHR10082:SF3
type: RelationshipXref
id: PTHR10082:SF3
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7FDA0 902
xref: PTHR10048:SF33
organism: Monodelphis domestica

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot P31938 138
xref: PTHR48013:SF5
organism: Mus musculus

PTHR10082:SF9
type: RelationshipXref
id: PTHR10082:SF9
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r111
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r111 1579
participant stoichiometry: PARTICIPANT STOICHIOMETRY r111 1580
left: ERK
interaction type: STATE_TRANSITION
right: ERK

Integrin subunit alpha 2b
type: ProteinReference
xref: PTHR23220:SF73
xref: uniprot F1PRU9 1021
organism: Canis lupus familiaris

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot Q7PMF0 946
xref: PTHR10048:SF7
organism: Anopheles gambiae

uniprot P29400 536
type: UnificationXref
id: P29400
db: uniprot

ADP-ribosylation factor-like protein 1
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot P61212 608
organism: Rattus norvegicus

ADP-ribosylation factor-like protein 1
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot P61211 607
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot E1B8P9 99
organism: Bos taurus

Viking, isoform A
type: ProteinReference
xref: uniprot Q9VMV5 579
organism: Drosophila melanogaster

Complex (Vinculin/Actin)
type: Complex
component stoichiometry: Actin s42 sa42 STOICHIOMETRY ID COMPLEX
component stoichiometry: Vinculin s41 sa41 STOICHIOMETRY ID COMPLEX
component: Vinculin
component: Actin
feature: COMPLEX BINDING FEATURE s262 a393 1373
feature: COMPLEX BINDING FEATURE s262 a393 1375
cellular location: cytoplasm

Complex (SOS/Grb2/ Shc)
type: Complex
component stoichiometry: Grb2 s85 sa65 STOICHIOMETRY ID COMPLEX
component stoichiometry: Shc s86 sa66 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS s84 sa64 STOICHIOMETRY ID COMPLEX
component: Shc
component: Grb2
component: SOS
feature: ACTIVE 89
feature: COMPLEX BINDING FEATURE s305 a452 1353
feature: COMPLEX BINDING FEATURE s305 a452 1351
feature: COMPLEX BINDING FEATURE s305 a452 1355
cellular location: cytoplasm

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 35

MODULATION
type: Control
xref: MODULATION
controlled: Actin polymerization
controller: Complex (Vinculin/PIP2/ VASP)

eco ECO:0000353 14
type: UnificationXref
id: ECO:0000353
db: eco

uniprot F1Q2Q9 886
type: UnificationXref
id: F1Q2Q9
db: uniprot

uniprot Q80ZJ1 83
type: UnificationXref
id: Q80ZJ1
db: uniprot

uniprot F7EU36 1133
type: UnificationXref
id: F7EU36
db: uniprot

Ras-related protein Rap-2b
type: ProteinReference
xref: PTHR24070:SF194
xref: uniprot P61227 67
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r88 1620
type: Stoichiometry
physical entity: Fyn
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r107
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r107 1605
participant stoichiometry: PARTICIPANT STOICHIOMETRY r107 1604
left: ERK
interaction type: STATE_TRANSITION
right: ERK

Ras-related protein Rap-2b
type: ProteinReference
xref: PTHR24070:SF194
xref: uniprot P61226 65
organism: Mus musculus

Ras-related protein Rap-2b
type: ProteinReference
xref: PTHR24070:SF194
xref: uniprot P61225 64
organism: Homo sapiens

Ras-related protein Rap-1b
type: ProteinReference
xref: PTHR24070:SF393
xref: uniprot P61224 63
organism: Homo sapiens

Ras-related protein Rap-1b
type: ProteinReference
xref: PTHR24070:SF393
xref: uniprot P61223 62
organism: Bos taurus

Alpha-actinin A
type: ProteinReference
xref: uniprot P05095 730
organism: Dictyostelium discoideum

uniprot F7HBI2 746
type: UnificationXref
id: F7HBI2
db: uniprot

Tyrosine-protein phosphatase non-receptor type 12
type: ProteinReference
xref: uniprot H2QUU0 281
xref: PTHR45983:SF3
organism: Pan troglodytes

PINCH
type: Protein
entity reference: PINCH
feature: COMPLEX PARTICIPANT BINDING FEATURE s375 sa85 1446
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 5786 28
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot Q2HJ68 1291
type: UnificationXref
id: Q2HJ68
db: uniprot

Crk-like protein
type: ProteinReference
xref: uniprot P47941 843
xref: PTHR19969:SF20
organism: Mus musculus

uniprot B3RIM6 1255
type: UnificationXref
id: B3RIM6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1N169 269
xref: PTHR38537:SF5
organism: Bos taurus

MAP2K4 protein
type: ProteinReference
xref: uniprot A5PJP8 647
xref: PTHR48013:SF15
organism: Bos taurus

Laminin s11 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Laminin
stoichiometric coefficient: 1.0

uniprot F6YCI3 376
type: UnificationXref
id: F6YCI3
db: uniprot

COL8A1 isoform 1
type: ProteinReference
xref: PTHR24023:SF903
xref: uniprot H2RD92 489
organism: Pan troglodytes

Collagen type V alpha 2 chain
type: ProteinReference
xref: uniprot F1LQ00 431
xref: PTHR24023:SF539
organism: Rattus norvegicus

PTHR10082:SF11
type: RelationshipXref
id: PTHR10082:SF11
db: PANTHER Family
relationship type: By Homology

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot P60952 967
organism: Canis lupus familiaris

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot F6WN02 213
xref: PTHR12644:SF1
organism: Ornithorhynchus anatinus

PTHR10082:SF15
type: RelationshipXref
id: PTHR10082:SF15
db: PANTHER Family
relationship type: By Homology

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P60953 968
xref: PTHR24072:SF136
organism: Homo sapiens

Alpha-actinin-1
type: ProteinReference
xref: PTHR11915:SF434
xref: uniprot P05094 729
organism: Gallus gallus

uniprot Q5KP06 1152
type: UnificationXref
id: Q5KP06
db: uniprot

uniprot B1NA68 649
type: UnificationXref
id: B1NA68
db: uniprot

PTHR10082:SF28
type: RelationshipXref
id: PTHR10082:SF28
db: PANTHER Family
relationship type: By Homology

Collagen type IX alpha 2 chain
type: ProteinReference
xref: uniprot D3ZNT5 421
xref: PTHR24023:SF906
organism: Rattus norvegicus

uniprot P49023 1322
type: UnificationXref
id: P49023
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F1MAI3 370
xref: PTHR23113:SF150
organism: Rattus norvegicus

Integrin subunit alpha 11
type: ProteinReference
xref: uniprot F1N157 1019
xref: PTHR23220:SF21
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot P90904 181
organism: Caenorhabditis elegans

uniprot E1C122 335
type: UnificationXref
id: E1C122
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GZQ3 1205
xref: PTHR10574:SF36
organism: Macaca mulatta

uniprot Q3ZC07 1148
type: UnificationXref
id: Q3ZC07
db: uniprot

uniprot H2R0G7 1340
type: UnificationXref
id: H2R0G7
db: uniprot

uniprot P28028 199
type: UnificationXref
id: P28028
db: uniprot

PTHR10082:SF26
type: RelationshipXref
id: PTHR10082:SF26
db: PANTHER Family
relationship type: By Homology

Fibronectin s10 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fibronectin
stoichiometric coefficient: 1.0

Integrin beta
type: ProteinReference
xref: PTHR10082:SF59
xref: uniprot Q7PME7 809
organism: Anopheles gambiae

PTHR10082:SF25
type: RelationshipXref
id: PTHR10082:SF25
db: PANTHER Family
relationship type: By Homology

Laminin subunit beta 3
type: ProteinReference
xref: PTHR10574:SF268
xref: uniprot F1LPI5 1192
organism: Rattus norvegicus

uniprot Q16787 1231
type: UnificationXref
id: Q16787
db: uniprot

PARTICIPANT STOICHIOMETRY r30 1591
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r30 1590
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot H2QV01 221
xref: PTHR10709:SF10
organism: Pan troglodytes

uniprot P10833 316
type: UnificationXref
id: P10833
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot H2QV00 220
organism: Pan troglodytes

PTHR10082:SF36
type: RelationshipXref
id: PTHR10082:SF36
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot Q62844 1101
organism: Rattus norvegicus

uniprot F6WVB2 1200
type: UnificationXref
id: F6WVB2
db: uniprot

uniprot H2R6C3 1044
type: UnificationXref
id: H2R6C3
db: uniprot

Collagen type II alpha 1 chain
type: ProteinReference
xref: PTHR24023:SF58
xref: uniprot F1PS24 443
organism: Canis lupus familiaris

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E2RFF7 256
xref: PTHR24418:SF407
organism: Canis lupus familiaris

ADP-ribosylation factor GTPase-activating protein 1
type: ProteinReference
xref: uniprot Q62848 184
organism: Rattus norvegicus

uniprot E1BDK6 1190
type: UnificationXref
id: E1BDK6
db: uniprot

Laminin subunit alpha 5
type: ProteinReference
xref: PTHR10574:SF261
xref: uniprot F1MAN8 1196
organism: Rattus norvegicus

VCL isoform 2
type: ProteinReference
xref: uniprot H2Q246 956
xref: PTHR46180:SF1
organism: Pan troglodytes

uniprot F1M614 1194
type: UnificationXref
id: F1M614
db: uniprot

Collagen alpha-1(XV) chain
type: ProteinReference
xref: PTHR24023:SF912
xref: uniprot P39059 538
organism: Homo sapiens

Paxillin
type: Protein
entity reference: Paxillin
feature: Paxillin s25 sa25 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa25 1482
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Caveolin-1
type: ProteinReference
xref: uniprot P49817 351
xref: PTHR10844:SF18
organism: Mus musculus

Shc
type: Protein
entity reference: Shc
feature: Shc s86 sa66 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s86 sa66 1356
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Laminin
type: Protein
entity reference: Laminin
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa6 1364
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot F6WN64 214
xref: PTHR12644:SF2
organism: Monodelphis domestica

Collagen alpha-1(V) chain
type: ProteinReference
xref: PTHR24023:SF387
xref: uniprot P20908 530
organism: Homo sapiens

PTHR10082:SF42
type: RelationshipXref
id: PTHR10082:SF42
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase CSK
type: ProteinReference
xref: PTHR24418:SF407
xref: uniprot P32577 261
organism: Rattus norvegicus

PTHR10082:SF41
type: RelationshipXref
id: PTHR10082:SF41
db: PANTHER Family
relationship type: By Homology

uniprot H2QL58 481
type: UnificationXref
id: H2QL58
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10574:SF233
xref: uniprot A0A3Q1MY30 1182
organism: Bos taurus

Paxillin s83 sa95 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

uniprot Q6GL60 701
type: UnificationXref
id: Q6GL60
db: uniprot

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: PTHR12058:SF0
xref: uniprot Q3MHR7 235
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot Q9JHG7 952
xref: PTHR10048:SF34
organism: Mus musculus

uniprot Q7KTZ2 945
type: UnificationXref
id: Q7KTZ2
db: uniprot

uniprot A0A3S5ZPX3 646
type: UnificationXref
id: A0A3S5ZPX3
db: uniprot

uniprot A0A2I3SKP4 1091
type: UnificationXref
id: A0A2I3SKP4
db: uniprot

Integrin alpha-D
type: ProteinReference
xref: PTHR23220:SF19
xref: uniprot Q9QYE7 1086
organism: Rattus norvegicus

PTHR10082:SF59
type: RelationshipXref
id: PTHR10082:SF59
db: PANTHER Family
relationship type: By Homology

Alpha-actinin-2
type: ProteinReference
xref: PTHR23167:SF22
xref: uniprot P20111 732
organism: Gallus gallus

uniprot Q00651 1070
type: UnificationXref
id: Q00651
db: uniprot

Collagen alpha-1(XVIII) chain
type: ProteinReference
xref: PTHR24023:SF1009
xref: uniprot P39061 539
organism: Mus musculus

uniprot F6SW23 889
type: UnificationXref
id: F6SW23
db: uniprot

uniprot Q61084 154
type: UnificationXref
id: Q61084
db: uniprot

Integrin alpha-V
type: ProteinReference
xref: PTHR23220:SF4
xref: uniprot A0A3Q1MXS2 1004
organism: Bos taurus

uniprot G3V7Q4 280
type: UnificationXref
id: G3V7Q4
db: uniprot

Tyrosine-protein kinase FRK
type: ProteinReference
xref: PTHR24418:SF419
xref: uniprot Q922K9 993
organism: Mus musculus

Tyrosine-protein kinase Src42A
type: ProteinReference
xref: uniprot Q9V9J3 994
xref: PTHR24418:SF431
organism: Drosophila melanogaster

Alpha-actinin-1
type: ProteinReference
xref: PTHR11915:SF434
xref: uniprot Q7TPR4 739
organism: Mus musculus

ncbitaxon 6238 204
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot F6YLW2 115
type: UnificationXref
id: F6YLW2
db: uniprot

uniprot F6W6R0 1023
type: UnificationXref
id: F6W6R0
db: uniprot

uniprot Q9QYE7 1086
type: UnificationXref
id: Q9QYE7
db: uniprot

uniprot P63259 1144
type: UnificationXref
id: P63259
db: uniprot

Integrin beta-2
type: ProteinReference
xref: uniprot P32592 798
xref: PTHR10082:SF15
organism: Bos taurus

PTHR24023:SF844
type: RelationshipXref
id: PTHR24023:SF844
db: PANTHER Family
relationship type: By Homology

uniprot H2Q6P9 602
type: UnificationXref
id: H2Q6P9
db: uniprot

uniprot A0A1D5QEY1 403
type: UnificationXref
id: A0A1D5QEY1
db: uniprot

uniprot A4FV00 1331
type: UnificationXref
id: A4FV00
db: uniprot

uniprot F7E7I7 1028
type: UnificationXref
id: F7E7I7
db: uniprot

uniprot F7DUD6 899
type: UnificationXref
id: F7DUD6
db: uniprot

uniprot F7AWM6 43
type: UnificationXref
id: F7AWM6
db: uniprot

uniprot A0A1D5PXC6 1328
type: UnificationXref
id: A0A1D5PXC6
db: uniprot

Collagen alpha-1(XX) chain
type: ProteinReference
xref: uniprot Q9P218 574
xref: PTHR24020:SF39
organism: Homo sapiens

Dock180
type: Protein
entity reference: Dock180
feature: COMPLEX PARTICIPANT BINDING FEATURE s80 sa92 1386
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 33

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7F3S0 901
organism: Macaca mulatta

uniprot J9P4S7 1271
type: UnificationXref
id: J9P4S7
db: uniprot

Complex (Crk/C3G/ p130CAS)
type: Complex
component stoichiometry: Crk s18 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: p130CAS s20 sa20 STOICHIOMETRY ID COMPLEX
component stoichiometry: C3G s19 sa19 STOICHIOMETRY ID COMPLEX
component: p130CAS
component: C3G
component: Crk
feature: ACTIVE 89
feature: COMPLEX BINDING FEATURE s204 a282 1479
feature: COMPLEX BINDING FEATURE s204 a282 1477
feature: COMPLEX BINDING FEATURE s204 a282 1475
cellular location: cytoplasm

PTHR24023:SF854
type: RelationshipXref
id: PTHR24023:SF854
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: uniprot Q62925 156
organism: Rattus norvegicus

uniprot P49186 1343
type: UnificationXref
id: P49186
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11711:SF357
xref: uniprot E2RNQ7 594
organism: Canis lupus familiaris

uniprot Q9DGD9 1349
type: UnificationXref
id: Q9DGD9
db: uniprot

uniprot F7FYA6 362
type: UnificationXref
id: F7FYA6
db: uniprot

uniprot Q13683 1073
type: UnificationXref
id: Q13683
db: uniprot

uniprot A0A0G2K2Q8 399
type: UnificationXref
id: A0A0G2K2Q8
db: uniprot

uniprot Q7K3H0 944
type: UnificationXref
id: Q7K3H0
db: uniprot

uniprot G2HG81 219
type: UnificationXref
id: G2HG81
db: uniprot

uniprot F6S8L5 1096
type: UnificationXref
id: F6S8L5
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot H2PXY8 908
organism: Pan troglodytes

uniprot F1MZ30 436
type: UnificationXref
id: F1MZ30
db: uniprot

Integrin subunit alpha 5
type: ProteinReference
xref: PTHR23220:SF3
xref: uniprot F6YFL0 1026
organism: Xenopus tropicalis

uniprot F6SRR1 773
type: UnificationXref
id: F6SRR1
db: uniprot

PTHR24023:SF866
type: RelationshipXref
id: PTHR24023:SF866
db: PANTHER Family
relationship type: By Homology

uniprot E2QY83 764
type: UnificationXref
id: E2QY83
db: uniprot

uniprot P01112 306
type: UnificationXref
id: P01112
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF194
xref: uniprot F7AWM6 43
organism: Macaca mulatta

Laminin subunit gamma 1
type: ProteinReference
xref: PTHR10574:SF270
xref: uniprot F1MAA7 1195
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A7I3 1130
xref: PTHR11937:SF477
organism: Monodelphis domestica

uniprot O93467 1273
type: UnificationXref
id: O93467
db: uniprot

uniprot F6QTB5 211
type: UnificationXref
id: F6QTB5
db: uniprot

uniprot F1MTN1 767
type: UnificationXref
id: F1MTN1
db: uniprot

STATE_TRANSITION_LEFT__Shc-RIGHT__Shc-_r48
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1517
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1518
left: Shc
interaction type: STATE_TRANSITION
right: Shc

Crk s18 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Crk
stoichiometric coefficient: 1.0

PTHR24023:SF877
type: RelationshipXref
id: PTHR24023:SF877
db: PANTHER Family
relationship type: By Homology

uniprot Q00780 542
type: UnificationXref
id: Q00780
db: uniprot

Actin s42 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Actin
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1PMN2 107
xref: PTHR24055:SF162
organism: Canis lupus familiaris

uniprot F6X9N6 215
type: UnificationXref
id: F6X9N6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23220:SF89
xref: uniprot F7HLW8 1033
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ES59 1265
xref: PTHR24072:SF100
organism: Monodelphis domestica

uniprot F6XSJ9 691
type: UnificationXref
id: F6XSJ9
db: uniprot

RND3 protein
type: ProteinReference
xref: PTHR24072:SF24
xref: uniprot A5PKJ7 1250
organism: Bos taurus

PTHR24023:SF871
type: RelationshipXref
id: PTHR24023:SF871
db: PANTHER Family
relationship type: By Homology

uniprot Q6PC73 193
type: UnificationXref
id: Q6PC73
db: uniprot

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot F1M9D0 103
organism: Rattus norvegicus

uniprot K7BGM3 492
type: UnificationXref
id: K7BGM3
db: uniprot

PARTICIPANT STOICHIOMETRY r117 1559
type: Stoichiometry
physical entity: Arf1
stoichiometric coefficient: 1.0

uniprot Q6IQX2 563
type: UnificationXref
id: Q6IQX2
db: uniprot

Integrin beta
type: ProteinReference
xref: PTHR10082:SF26
xref: uniprot F7GE04 777
organism: Macaca mulatta

PTHR24023:SF880
type: RelationshipXref
id: PTHR24023:SF880
db: PANTHER Family
relationship type: By Homology

uniprot P61223 62
type: UnificationXref
id: P61223
db: uniprot

uniprot H9FU32 633
type: UnificationXref
id: H9FU32
db: uniprot

uniprot A0A2I3T8Z7 407
type: UnificationXref
id: A0A2I3T8Z7
db: uniprot

PTHR23220:SF130
type: RelationshipXref
id: PTHR23220:SF130
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r117 1560
type: Stoichiometry
physical entity: Arf1
stoichiometric coefficient: 1.0

uniprot A0A3Q1MNG1 645
type: UnificationXref
id: A0A3Q1MNG1
db: uniprot

uniprot D3ZMS4 671
type: UnificationXref
id: D3ZMS4
db: uniprot

Collagen alpha-1(X) chain
type: ProteinReference
xref: uniprot F1MZ30 436
xref: PTHR24023:SF880
organism: Bos taurus

uniprot F7FN72 217
type: UnificationXref
id: F7FN72
db: uniprot

uniprot P11345 639
type: UnificationXref
id: P11345
db: uniprot

PTHR24023:SF891
type: RelationshipXref
id: PTHR24023:SF891
db: PANTHER Family
relationship type: By Homology

Collagen alpha-1(X) chain
type: ProteinReference
xref: uniprot Q05306 548
xref: PTHR24023:SF880
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot F6XSJ9 691
organism: Macaca mulatta

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 643
xref: PTHR44329:SF22
xref: uniprot Q99N57 642
organism: Mus musculus

uniprot F1LUU1 1014
type: UnificationXref
id: F1LUU1
db: uniprot

RAP2B isoform 1
type: ProteinReference
xref: PTHR24070:SF194
xref: uniprot H2QNL9 53
organism: Pan troglodytes

PTHR24055:SF341
type: RelationshipXref
id: PTHR24055:SF341
db: PANTHER Family
relationship type: By Homology

Laminin subunit alpha-2
type: ProteinReference
xref: PTHR10574:SF291
xref: uniprot Q60675 1235
organism: Mus musculus

uniprot Q8VI36 1327
type: UnificationXref
id: Q8VI36
db: uniprot

uniprot Q9QXH4 1085
type: UnificationXref
id: Q9QXH4
db: uniprot

Integrin alpha-E
type: ProteinReference
xref: uniprot Q60677 1076
xref: PTHR23220:SF79
organism: Mus musculus

uniprot Q6P2U5 368
type: UnificationXref
id: Q6P2U5
db: uniprot

uniprot P46108 841
type: UnificationXref
id: P46108
db: uniprot

FAK s17 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

GRAF
type: Protein
entity reference: GRAF
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot E7F144 26
type: UnificationXref
id: E7F144
db: uniprot

uniprot A0A1D5QE27 864
type: UnificationXref
id: A0A1D5QE27
db: uniprot

PTHR23220:SF118
type: RelationshipXref
id: PTHR23220:SF118
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9031 22
type: UnificationXref
id: 9031
db: ncbitaxon

Ras-related protein Rap-1b
type: ProteinReference
xref: PTHR24070:SF393
xref: uniprot Q6TEN1 81
organism: Danio rerio

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6Y4G8 1336
organism: Canis lupus familiaris

ncbitaxon 81824 1119
type: UnificationXref
id: 81824
db: ncbitaxon

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot Q1HG70 667
organism: Canis lupus familiaris

Collagen alpha-1(XVI) chain
type: ProteinReference
xref: PTHR24023:SF372
xref: uniprot Q07092 551
organism: Homo sapiens

C3G s19 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: C3G
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r88 1619
type: Stoichiometry
physical entity: Fyn
stoichiometric coefficient: 1.0

uniprot F1PHK9 1197
type: UnificationXref
id: F1PHK9
db: uniprot

GTPase HRas
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot P08642 311
organism: Gallus gallus

Collagen alpha-1(V) chain
type: ProteinReference
xref: PTHR24023:SF387
xref: uniprot Q9JI03 571
organism: Rattus norvegicus

PTHR10709:SF10
type: RelationshipXref
id: PTHR10709:SF10
db: PANTHER Family
relationship type: By Homology

PTHR23220:SF123
type: RelationshipXref
id: PTHR23220:SF123
db: PANTHER Family
relationship type: By Homology

Alpha 4 type V collagen
type: ProteinReference
xref: PTHR24023:SF1023
xref: uniprot Q9JI04 572
organism: Rattus norvegicus

PTHR10709:SF11
type: RelationshipXref
id: PTHR10709:SF11
db: PANTHER Family
relationship type: By Homology

PTHR23220:SF122
type: RelationshipXref
id: PTHR23220:SF122
db: PANTHER Family
relationship type: By Homology

Integrin alpha-5
type: ProteinReference
xref: uniprot P08648 1052
xref: PTHR23220:SF3
organism: Homo sapiens

Ras-like protein 1
type: ProteinReference
xref: uniprot P08646 312
xref: PTHR24070:SF420
organism: Drosophila melanogaster

Ras-related protein Rap1
type: ProteinReference
xref: PTHR24070:SF263
xref: uniprot P08645 57
organism: Drosophila melanogaster

uniprot Q27874 803
type: UnificationXref
id: Q27874
db: uniprot

uniprot A0A287AGL0 176
type: UnificationXref
id: A0A287AGL0
db: uniprot

uniprot F7A403 1202
type: UnificationXref
id: F7A403
db: uniprot

Integrin alpha-L
type: ProteinReference
xref: PTHR23220:SF84
xref: uniprot P24063 1062
organism: Mus musculus

Filamin-B
type: ProteinReference
xref: PTHR38537:SF7
xref: uniprot O75369 274
organism: Homo sapiens

uniprot F6TVC2 673
type: UnificationXref
id: F6TVC2
db: uniprot

LAMB3 isoform 1
type: ProteinReference
xref: uniprot A0A2J8QVK7 1181
xref: PTHR10574:SF268
organism: Pan troglodytes

ACTin
type: ProteinReference
xref: uniprot O45815 1136
xref: PTHR11937:SF359
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
xref: uniprot F6V6S9 449
xref: PTHR24023:SF539
organism: Macaca mulatta

uniprot F7F3S0 901
type: UnificationXref
id: F7F3S0
db: uniprot

uniprot F7FG65 1097
type: UnificationXref
id: F7FG65
db: uniprot

Vinculin
type: Protein
entity reference: Vinculin
feature: COMPLEX PARTICIPANT BINDING FEATURE s68 sa74 1462
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q00174 1227
type: UnificationXref
id: Q00174
db: uniprot

PI3K s210 a297 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

PARTICIPANT STOICHIOMETRY r118 1557
type: Stoichiometry
physical entity: Arf6
stoichiometric coefficient: 1.0

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF4
xref: uniprot J9P309 224
organism: Canis lupus familiaris

HRas proto-oncogene, GTPase a
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot F1QNG4 297
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r77 1537
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r77 1536
type: Stoichiometry
physical entity: Complex (ILK/PINCH/ Parvin)
stoichiometric coefficient: 1.0

uniprot D3ZUL3 422
type: UnificationXref
id: D3ZUL3
db: uniprot

PARTICIPANT STOICHIOMETRY r77 1539
type: Stoichiometry
physical entity: Complex (Integrin beta/Integrin _alpha/ Paxillin/FAK/ Talin/Vinculin/ Actin/Integrin _alpha/ alpha actinin/Actin/ Integrin beta/Filamin/ Collagen/Laminin/ Fibronectin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r77 1538
type: Stoichiometry
physical entity: Complex (Integrin _alpha/Paxillin/ Integrin beta/Talin/ Vinculin/Actin/ Integrin _alpha/alpha actinin/ Actin/Integrin beta/ Filamin/Collagen/ Laminin/Fibronectin)
stoichiometric coefficient: 1.0

uniprot A0A2I3T7A8 868
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

uniprot Q64010 846
type: UnificationXref
id: Q64010
db: uniprot

Multiple epidermal growth factor-like domains protein 9
type: ProteinReference
xref: PTHR10574:SF298
xref: uniprot Q8BH27 1242
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F1MYM3 885
organism: Bos taurus

Netrin-4
type: ProteinReference
xref: uniprot Q9JI33 1245
xref: PTHR10574:SF282
organism: Mus musculus

uniprot A8XAF1 417
type: UnificationXref
id: A8XAF1
db: uniprot

Laminin subunit alpha-2
type: ProteinReference
xref: PTHR10574:SF291
xref: uniprot P24043 1223
organism: Homo sapiens

uniprot P05555 1049
type: UnificationXref
id: P05555
db: uniprot

uniprot H2QRP5 676
type: UnificationXref
id: H2QRP5
db: uniprot

uniprot P20111 732
type: UnificationXref
id: P20111
db: uniprot

PARTICIPANT STOICHIOMETRY r118 1558
type: Stoichiometry
physical entity: Arf6
stoichiometric coefficient: 1.0

ncbitaxon 6669 293
type: UnificationXref
id: 6669
db: ncbitaxon

Integrin subunit alpha 2
type: ProteinReference
xref: PTHR23220:SF23
xref: uniprot A0A0G2K470 997
organism: Rattus norvegicus

Integrin beta-3
type: ProteinReference
xref: PTHR10082:SF25
xref: uniprot O54890 783
organism: Mus musculus

uniprot P50552 850
type: UnificationXref
id: P50552
db: uniprot

uniprot P46109 842
type: UnificationXref
id: P46109
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11711:SF41
xref: uniprot A0A1L1RMP9 584
organism: Gallus gallus

uniprot P49817 351
type: UnificationXref
id: P49817
db: uniprot

uniprot P63001 698
type: UnificationXref
id: P63001
db: uniprot

PANTHER Pathway P00034 1
type: UnificationXref
id: P00034
db: PANTHER Pathway

CED-5
type: ProteinReference
xref: uniprot G5EEN3 751
organism: Caenorhabditis elegans

Rho-related GTP-binding protein RhoB
type: ProteinReference
xref: PTHR24072:SF0
xref: uniprot Q3ZBW5 1292
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR12114:SF7
xref: uniprot F6QBF0 1164
organism: Macaca mulatta

uniprot P20785 528
type: UnificationXref
id: P20785
db: uniprot

uniprot A0A2I3T5H5 1000
type: UnificationXref
id: A0A2I3T5H5
db: uniprot

PTHR12058:SF0
type: RelationshipXref
id: PTHR12058:SF0
db: PANTHER Family
relationship type: By Homology

Integrin beta
type: ProteinReference
xref: PTHR10082:SF9
xref: uniprot F7F3K9 775
organism: Macaca mulatta

uniprot P33724 349
type: UnificationXref
id: P33724
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q3T0N5 148
organism: Bos taurus

Engulfment and cell motility protein 2
type: ProteinReference
xref: PTHR12771:SF8
xref: uniprot Q8BHL5 344
organism: Mus musculus

uniprot P08646 312
type: UnificationXref
id: P08646
db: uniprot

Fibronectin
type: Protein
entity reference: Fibronectin
feature: COMPLEX PARTICIPANT BINDING FEATURE s40 sa40 1436
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot O55222 856
type: UnificationXref
id: O55222
db: uniprot

uniprot P10398 638
type: UnificationXref
id: P10398
db: uniprot

Laminin subunit alpha-4
type: ProteinReference
xref: uniprot P97927 1226
xref: PTHR15036:SF47
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1N9E9 1184
xref: PTHR15036:SF47
organism: Bos taurus

Laminin subunit beta 2
type: ProteinReference
xref: uniprot E2R4J1 1191
xref: PTHR10574:SF36
organism: Canis lupus familiaris

Harvey rat sarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot Q28EW2 326
organism: Xenopus tropicalis

Collagen alpha-3(VI) chain
type: ProteinReference
xref: uniprot P15989 525
xref: PTHR24020:SF13
organism: Gallus gallus

Talin 1
type: ProteinReference
xref: uniprot F1PSC2 1105
xref: PTHR19981:SF7
organism: Canis lupus familiaris

Collagen alpha-2(VI) chain
type: ProteinReference
xref: uniprot P15988 524
xref: PTHR24020:SF29
organism: Gallus gallus

Parvin
type: Protein
entity reference: Parvin
feature: COMPLEX PARTICIPANT BINDING FEATURE s62 sa89 1490
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A0R4IKK9 91
xref: PTHR24055:SF162
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F6U702 848
xref: PTHR11202:SF12
organism: Macaca mulatta

RAP1A, member of RAS oncogene family
type: ProteinReference
xref: uniprot Q6IQP4 80
xref: PTHR24070:SF424
organism: Danio rerio

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

Parvin s376 sa86 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Parvin
stoichiometric coefficient: 1.0

uniprot P84080 612
type: UnificationXref
id: P84080
db: uniprot

Collagen alpha-1(IV) chain
type: ProteinReference
xref: PTHR24023:SF854
xref: uniprot P02463 505
organism: Mus musculus

Collagen alpha-2(I) chain
type: ProteinReference
xref: PTHR24023:SF568
xref: uniprot P02466 507
organism: Rattus norvegicus

Collagen alpha-2(I) chain
type: ProteinReference
xref: PTHR24023:SF568
xref: uniprot P02465 506
organism: Bos taurus

Laminin subunit gamma-1
type: ProteinReference
xref: PTHR10574:SF270
xref: uniprot P02468 1216
organism: Mus musculus

Collagen alpha-2(I) chain
type: ProteinReference
xref: PTHR24023:SF568
xref: uniprot P02467 508
organism: Gallus gallus

Wing blister, isoform B
type: ProteinReference
xref: PTHR10574:SF405
xref: uniprot Q8IP51 1243
organism: Drosophila melanogaster

uniprot P02466 507
type: UnificationXref
id: P02466
db: uniprot

Laminin subunit beta-1
type: ProteinReference
xref: uniprot P02469 1217
xref: PTHR10574:SF233
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6WWC5 338
xref: PTHR12771:SF8
organism: Macaca mulatta

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot H2QNG6 911
organism: Pan troglodytes

uniprot F7GCM2 272
type: UnificationXref
id: F7GCM2
db: uniprot

Collagen alpha-1(IV) chain
type: ProteinReference
xref: PTHR24023:SF854
xref: uniprot P02462 504
organism: Homo sapiens

Collagen alpha-1(III) chain
type: ProteinReference
xref: PTHR24023:SF604
xref: uniprot P02461 503
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TUR3 1127
xref: PTHR11937:SF192
organism: Monodelphis domestica

Integrin beta-5
type: ProteinReference
xref: PTHR10082:SF26
xref: uniprot P80747 801
organism: Bos taurus

uniprot H2QV85 1211
type: UnificationXref
id: H2QV85
db: uniprot

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot A0A0G2K3R1 90
organism: Rattus norvegicus

uniprot Q9EPJ9 186
type: UnificationXref
id: Q9EPJ9
db: uniprot

uniprot Q8BTM8 277
type: UnificationXref
id: Q8BTM8
db: uniprot

uniprot F1MEF6 1015
type: UnificationXref
id: F1MEF6
db: uniprot

PARTICIPANT STOICHIOMETRY r91 1596
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7GN93 120
xref: PTHR24055:SF162
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r91 1597
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

Collagen alpha-1(I) chain
type: ProteinReference
xref: PTHR24023:SF569
xref: uniprot P02454 500
organism: Rattus norvegicus

Collagen alpha-1(I) chain
type: ProteinReference
xref: uniprot P02453 499
xref: PTHR24023:SF569
organism: Bos taurus

Collagen alpha-1(I) chain
type: ProteinReference
xref: uniprot P02452 498
xref: PTHR24023:SF569
organism: Homo sapiens

Collagen alpha-1(II) chain
type: ProteinReference
xref: PTHR24023:SF58
xref: uniprot P02459 502
organism: Bos taurus

Collagen alpha-1(II) chain
type: ProteinReference
xref: PTHR24023:SF58
xref: uniprot P02458 501
organism: Homo sapiens

ADP ribosylation factor like GTPase 1
type: ProteinReference
xref: uniprot E2RG67 593
xref: PTHR11711:SF41
organism: Canis lupus familiaris

uniprot F1PWW0 270
type: UnificationXref
id: F1PWW0
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot Q5ZJI7 241
xref: PTHR10709:SF11
organism: Gallus gallus

Ras-related protein Rap-1b
type: ProteinReference
xref: PTHR24070:SF393
xref: uniprot A5A6J7 10
organism: Pan troglodytes

uniprot Q21313 1233
type: UnificationXref
id: Q21313
db: uniprot

Alpha-actinin-2
type: ProteinReference
xref: uniprot Q9JI91 742
xref: PTHR11915:SF429
organism: Mus musculus

PI3K
type: Protein
entity reference: PI3K
feature: PI3K s210 a297 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P05556 787
type: UnificationXref
id: P05556
db: uniprot

Actin
type: ProteinReference
xref: uniprot Q5KP06 1152
xref: PTHR11937:SF387
organism: Cryptococcus neoformans

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot Q5E9B5 1151
organism: Bos taurus

alpha actinin s34 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha actinin
stoichiometric coefficient: 1.0

uniprot P63000 697
type: UnificationXref
id: P63000
db: uniprot

Laminin subunit alpha 4
type: ProteinReference
xref: uniprot K7CW88 1213
xref: PTHR15036:SF47
organism: Pan troglodytes

uniprot P25391 1224
type: UnificationXref
id: P25391
db: uniprot

uniprot H2QJ29 1041
type: UnificationXref
id: H2QJ29
db: uniprot

RAS related
type: ProteinReference
xref: uniprot K7CW85 304
xref: PTHR24070:SF245
organism: Pan troglodytes

Complex (p130CAS/Crk/ Dock180/ELMO)
type: Complex
component stoichiometry: Crk s79 sa91 STOICHIOMETRY ID COMPLEX
component stoichiometry: Dock180 s80 sa92 STOICHIOMETRY ID COMPLEX
component stoichiometry: ELMO s81 sa93 STOICHIOMETRY ID COMPLEX
component stoichiometry: p130CAS s78 sa90 STOICHIOMETRY ID COMPLEX
component: Crk
component: ELMO
component: Dock180
component: p130CAS
feature: COMPLEX BINDING FEATURE s359 a565 1387
feature: ACTIVE 89
feature: COMPLEX BINDING FEATURE s359 a565 1381
feature: COMPLEX BINDING FEATURE s359 a565 1385
feature: COMPLEX BINDING FEATURE s359 a565 1383
cellular location: cytoplasm

RE63021p
type: ProteinReference
xref: uniprot O96692 55
organism: Drosophila melanogaster

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 635
xref: uniprot P04049 634
xref: PTHR44329:SF22
organism: Homo sapiens

Collagen alpha-1(XIII) chain
type: ProteinReference
xref: PTHR24023:SF871
xref: uniprot Q9R1N9 577
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EG27 463
xref: PTHR24023:SF42
organism: Monodelphis domestica

Integrin beta s45 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Integrin beta
stoichiometric coefficient: 2.0

Uncharacterized protein
type: ProteinReference
xref: PTHR10574:SF233
xref: uniprot A0A1D5Q585 1177
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot C3YJC1 684
organism: Branchiostoma floridae

uniprot A0A2I3TK00 196
type: UnificationXref
id: A0A2I3TK00
db: uniprot

uniprot D3ZZW1 749
type: UnificationXref
id: D3ZZW1
db: uniprot

uniprot Q7QAC8 1082
type: UnificationXref
id: Q7QAC8
db: uniprot

uniprot F7ES59 1265
type: UnificationXref
id: F7ES59
db: uniprot

Breast cancer anti-estrogen resistance protein 1
type: ProteinReference
xref: uniprot Q61140 172
xref: PTHR10654:SF15
organism: Mus musculus

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot Q9Y2U5 166
organism: Homo sapiens

uniprot F6V2H6 113
type: UnificationXref
id: F6V2H6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r90
controller: Ras

ASAP1 isoform 2
type: ProteinReference
xref: uniprot K7D7X0 179
organism: Pan troglodytes

FAK
type: Protein
entity reference: FAK
feature: Y397 FAK s134 a146 rs1
feature: FAK s134 a146 rs4
feature: Y925 FAK s134 a146 rs2
feature: FAK s134 a146 rs3
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7DGX0 45
type: UnificationXref
id: F7DGX0
db: uniprot

Cdc42
type: Protein
entity reference: Cdc42
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7HGW0 471
type: UnificationXref
id: F7HGW0
db: uniprot

Filamin-A
type: ProteinReference
xref: uniprot Q8BTM8 277
xref: PTHR38537:SF5
organism: Mus musculus

PTHR11937:SF201
type: RelationshipXref
id: PTHR11937:SF201
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__PTP_PEST-_Paxillin-RIGHT__Complex__Paxillin_PTP_PEST_-_r35
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 1569
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 1567
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 1568
left: PTP-PEST
left: Paxillin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Paxillin/PTP-PEST)

Caveolin
type: Protein
entity reference: Caveolin
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot H2Q894 364
type: UnificationXref
id: H2Q894
db: uniprot

uniprot E1BE66 878
type: UnificationXref
id: E1BE66
db: uniprot

uniprot F7BZM9 216
type: UnificationXref
id: F7BZM9
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot F6X9N6 215
xref: PTHR12644:SF1
organism: Monodelphis domestica

Integrin subunit alpha E
type: ProteinReference
xref: PTHR23220:SF79
xref: uniprot A0A2I3TFS6 1001
organism: Pan troglodytes

RAP1A isoform 1
type: ProteinReference
xref: uniprot A0A2I3T5X3 3
xref: PTHR24070:SF395
organism: Pan troglodytes

Protein tyrosine kinase 2 beta
type: ProteinReference
xref: PTHR24418:SF94
xref: uniprot F6Z395 824
organism: Monodelphis domestica

uniprot F6WWC5 338
type: UnificationXref
id: F6WWC5
db: uniprot

Vinculin
type: ProteinReference
xref: PTHR46180:SF1
xref: uniprot Q64727 961
organism: Mus musculus

Integrin subunit alpha 9
type: ProteinReference
xref: PTHR23220:SF69
xref: uniprot F6T4B4 1022
organism: Macaca mulatta

Cell division cycle 42
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot Q28BZ0 970
organism: Xenopus tropicalis

RAP2B protein
type: ProteinReference
xref: PTHR24070:SF194
xref: uniprot A4IFU2 9
organism: Bos taurus

uniprot Q2QLF2 354
type: UnificationXref
id: Q2QLF2
db: uniprot

uniprot D3ZK56 19
type: UnificationXref
id: D3ZK56
db: uniprot

uniprot Q2TBH2 327
type: UnificationXref
id: Q2TBH2
db: uniprot

uniprot Q9W1M8 1090
type: UnificationXref
id: Q9W1M8
db: uniprot

uniprot Q92071 813
type: UnificationXref
id: Q92071
db: uniprot

uniprot K7C5Y1 1212
type: UnificationXref
id: K7C5Y1
db: uniprot

uniprot Q23158 736
type: UnificationXref
id: Q23158
db: uniprot

Integrin subunit alpha 9
type: ProteinReference
xref: PTHR23220:SF69
xref: uniprot D3ZN51 1008
organism: Rattus norvegicus

uniprot K7E435 782
type: UnificationXref
id: K7E435
db: uniprot

VASP
type: Protein
entity reference: VASP
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot E1B847 98
organism: Bos taurus

uniprot A0A2J8QY32 870
type: UnificationXref
id: A0A2J8QY32
db: uniprot

Collagen type VI alpha 2 chain
type: ProteinReference
xref: uniprot H2QL58 481
xref: PTHR24020:SF29
organism: Pan troglodytes

Ras-related protein Rap-2c
type: ProteinReference
xref: PTHR24070:SF200
xref: uniprot F6VPD5 36
organism: Macaca mulatta

uniprot G3V667 1034
type: UnificationXref
id: G3V667
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7C2W0 854
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF200
xref: uniprot F1P231 30
organism: Gallus gallus

ADP-ribosylation factor GTPase-activating protein 1
type: ProteinReference
xref: uniprot Q9EPJ9 186
organism: Mus musculus

uniprot P01120 309
type: UnificationXref
id: P01120
db: uniprot

uniprot H2Q0R1 1207
type: UnificationXref
id: H2Q0R1
db: uniprot

PARTICIPANT STOICHIOMETRY r48 1518
type: Stoichiometry
physical entity: Shc
stoichiometric coefficient: 1.0

uniprot P61586 1279
type: UnificationXref
id: P61586
db: uniprot

PARTICIPANT STOICHIOMETRY r48 1517
type: Stoichiometry
physical entity: Shc
stoichiometric coefficient: 1.0

uniprot Q8NEB9 949
type: UnificationXref
id: Q8NEB9
db: uniprot

uniprot P85972 960
type: UnificationXref
id: P85972
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 627
evidence: Evidence 625
evidence: Evidence 626
evidence: Evidence 624
xref: PTHR44329:SF22
xref: uniprot A0A1D5R9U8 623
organism: Macaca mulatta

Collagen type VI alpha 1 chain
type: ProteinReference
xref: uniprot E1BI98 427
xref: PTHR24020:SF18
organism: Bos taurus

Rho-related GTP-binding protein Rho6
type: ProteinReference
xref: uniprot Q8BLR7 1302
xref: PTHR24072:SF23
organism: Mus musculus

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: uniprot O88656 230
xref: PTHR10709:SF10
organism: Rattus norvegicus

uniprot Q64632 806
type: UnificationXref
id: Q64632
db: uniprot

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: uniprot Q58CQ2 239
xref: PTHR10709:SF10
organism: Bos taurus

CRK like proto-oncogene, adaptor protein
type: ProteinReference
xref: uniprot F1P241 837
xref: PTHR19969:SF20
organism: Gallus gallus

uniprot F7GZQ3 1205
type: UnificationXref
id: F7GZQ3
db: uniprot

Actin s69 sa75 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Actin
stoichiometric coefficient: 2.0

uniprot A0A3Q1M970 411
type: UnificationXref
id: A0A3Q1M970
db: uniprot

Ras-related protein Rap-1A
type: ProteinReference
xref: PTHR24070:SF395
xref: uniprot P62835 70
organism: Mus musculus

Ras-related protein Rap-1A
type: ProteinReference
xref: PTHR24070:SF395
xref: uniprot P62834 69
organism: Homo sapiens

Actinin alpha 3
type: ProteinReference
xref: PTHR11915:SF432
xref: uniprot Q8R4I6 741
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot C3Z3B1 591
xref: PTHR11711:SF381
organism: Branchiostoma floridae

Ras-related protein Rap-1A
type: ProteinReference
xref: PTHR24070:SF395
xref: uniprot P62833 68
organism: Bos taurus

COL9A3 isoform 2
type: ProteinReference
xref: PTHR24023:SF866
xref: uniprot H2QKR5 480
organism: Pan troglodytes

Protein tyrosine kinase 2 beta
type: ProteinReference
xref: uniprot E2QTG4 821
xref: PTHR24418:SF94
organism: Canis lupus familiaris

RAS related
type: ProteinReference
xref: PTHR24070:SF245
xref: uniprot E2R5G6 291
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: PTHR11915:SF432
xref: uniprot F6QQX8 717
organism: Macaca mulatta

uniprot P54675 937
type: UnificationXref
id: P54675
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 640
xref: uniprot P11345 639
xref: PTHR44329:SF22
organism: Rattus norvegicus

uniprot F1LRH4 1193
type: UnificationXref
id: F1LRH4
db: uniprot

Alpha-actinin-4
type: ProteinReference
xref: uniprot Q9QXQ0 743
xref: PTHR11915:SF425
organism: Rattus norvegicus

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: PTHR12644:SF0
xref: uniprot Q9VQD8 252
organism: Drosophila melanogaster

Ras-related protein Rap-1A
type: ProteinReference
xref: PTHR24070:SF395
xref: uniprot P62836 71
organism: Rattus norvegicus

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot O15264 132
organism: Homo sapiens

ADP ribosylation factor GTPase activating protein 1
type: ProteinReference
xref: uniprot H2QKS2 178
organism: Pan troglodytes

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot O96626 231
xref: PTHR12644:SF0
organism: Dictyostelium discoideum

uniprot Q6P378 1155
type: UnificationXref
id: Q6P378
db: uniprot

Ras-related protein Rap-2c
type: ProteinReference
xref: uniprot Q8BU31 84
xref: PTHR24070:SF200
organism: Mus musculus

uniprot A0A1D5QJY6 865
type: UnificationXref
id: A0A1D5QJY6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TFL4 110
xref: PTHR24055:SF171
organism: Monodelphis domestica

Integrin linked kinase
type: ProteinReference
xref: uniprot E2R5H4 853
organism: Canis lupus familiaris

uniprot H2PXY8 908
type: UnificationXref
id: H2PXY8
db: uniprot

p130CAS
type: Protein
entity reference: p130CAS
feature: p130CAS s182 a244 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P16144 792
type: UnificationXref
id: P16144
db: uniprot

uniprot F6V6S9 449
type: UnificationXref
id: F6V6S9
db: uniprot

uniprot F7CYE3 118
type: UnificationXref
id: F7CYE3
db: uniprot

MICAL-like protein 1
type: ProteinReference
xref: uniprot Q8N3F8 740
organism: Homo sapiens

uniprot Q9N272 163
type: UnificationXref
id: Q9N272
db: uniprot

uniprot F1NQ20 438
type: UnificationXref
id: F1NQ20
db: uniprot

uniprot H2QE24 1134
type: UnificationXref
id: H2QE24
db: uniprot

uniprot F6Z395 824
type: UnificationXref
id: F6Z395
db: uniprot

uniprot P23726 924
type: UnificationXref
id: P23726
db: uniprot

FAK
type: Protein
entity reference: FAK
feature: FAK s17 sa17 rs3
feature: ACTIVE 89
feature: Y925 FAK s17 sa17 rs2
feature: Y397 FAK s17 sa17 rs1
feature: FAK s17 sa17 rs4
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa17 1442
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot O35346 827
type: UnificationXref
id: O35346
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7B5L8 1338
xref: PTHR24055:SF172
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot F7ALP1 1131
organism: Monodelphis domestica

PTHR19331:SF22
type: RelationshipXref
id: PTHR19331:SF22
db: PANTHER Family
relationship type: By Homology

Phosphoinositide-3-kinase regulatory subunit 3
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot A0A2I3RH39 866
organism: Pan troglodytes

uniprot C0JPT7 267
type: UnificationXref
id: C0JPT7
db: uniprot

PARTICIPANT STOICHIOMETRY r34 1576
type: Stoichiometry
physical entity: Complex (Paxillin/Crk)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r34 1575
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

uniprot Q9WTU6 1350
type: UnificationXref
id: Q9WTU6
db: uniprot

PARTICIPANT STOICHIOMETRY r34 1574
type: Stoichiometry
physical entity: Crk
stoichiometric coefficient: 1.0

uniprot K7C248 677
type: UnificationXref
id: K7C248
db: uniprot

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot G5E577 122
xref: PTHR24055:SF171
organism: Bos taurus

uniprot F7BZL6 898
type: UnificationXref
id: F7BZL6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r92
controller: MEK

Arf6
type: Protein
entity reference: Arf6
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Collagen type VI alpha 1 chain
type: ProteinReference
xref: PTHR24023:SF917
xref: uniprot D3ZUL3 422
organism: Rattus norvegicus

uniprot A0A2I3T3L8 816
type: UnificationXref
id: A0A2I3T3L8
db: uniprot

uniprot P13941 521
type: UnificationXref
id: P13941
db: uniprot

uniprot A0A2I3TPM4 762
type: UnificationXref
id: A0A2I3TPM4
db: uniprot

uniprot E1BQ32 835
type: UnificationXref
id: E1BQ32
db: uniprot

Protein son of sevenless
type: ProteinReference
xref: uniprot P26675 381
xref: PTHR23113:SF341
organism: Drosophila melanogaster

uniprot P35609 733
type: UnificationXref
id: P35609
db: uniprot

Collagen alpha-5(IV) chain
type: ProteinReference
xref: PTHR24023:SF877
xref: uniprot P29400 536
organism: Homo sapiens

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q9TU25 705
organism: Bos taurus

SOS
type: Protein
entity reference: SOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s84 sa64 1352
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7HL22 1108
type: UnificationXref
id: F7HL22
db: uniprot

Integrin linked kinase
type: ProteinReference
xref: uniprot A0A2I3RP73 852
organism: Pan troglodytes

uniprot A9JRY8 683
type: UnificationXref
id: A9JRY8
db: uniprot

uniprot A0A1D5P4L2 1176
type: UnificationXref
id: A0A1D5P4L2
db: uniprot

Ras-like GTP-binding protein Rho1
type: ProteinReference
xref: uniprot P48148 1276
xref: PTHR24072:SF168
organism: Drosophila melanogaster

ERK
type: Protein
entity reference: ERK
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F5HMC8 32
type: UnificationXref
id: F5HMC8
db: uniprot

uniprot A0A3Q1LQK4 871
type: UnificationXref
id: A0A3Q1LQK4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BQ32 835
xref: PTHR19969:SF8
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r31
controller: FAK

Integrin-linked protein kinase
type: ProteinReference
xref: uniprot O55222 856
organism: Mus musculus

uniprot Q63258 1081
type: UnificationXref
id: Q63258
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H1M7 469
xref: PTHR24023:SF903
organism: Macaca mulatta

COL4A5 isoform 2
type: ProteinReference
xref: PTHR24023:SF877
xref: uniprot K7ARM1 491
organism: Pan troglodytes

uniprot F6VXG1 893
type: UnificationXref
id: F6VXG1
db: uniprot

PARTICIPANT STOICHIOMETRY r108 1602
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

uniprot P53779 141
type: UnificationXref
id: P53779
db: uniprot

p130CAS s20 sa20 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.9229354047838125
comment: MODIFICATION_RESIDUE_NAME=

uniprot Q92556 346
type: UnificationXref
id: Q92556
db: uniprot

uniprot F7F5K9 300
type: UnificationXref
id: F7F5K9
db: uniprot

PARTICIPANT STOICHIOMETRY r108 1603
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

ERK
type: Protein
entity reference: ERK
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P70460 851
type: UnificationXref
id: P70460
db: uniprot

COL10A1 isoform 2
type: ProteinReference
xref: uniprot H2QTL5 483
xref: PTHR24023:SF880
organism: Pan troglodytes

uniprot Q8BLR7 1302
type: UnificationXref
id: Q8BLR7
db: uniprot

PI3K s211 a299 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot O95965 785
type: UnificationXref
id: O95965
db: uniprot

uniprot A0A3Q1N508 819
type: UnificationXref
id: A0A3Q1N508
db: uniprot

Sus scrofa
type: BioSource
xref: ncbitaxon 9823 177

uniprot F7F6L1 724
type: UnificationXref
id: F7F6L1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q4K0 402
xref: PTHR24020:SF17
organism: Macaca mulatta

uniprot F7CS91 1263
type: UnificationXref
id: F7CS91
db: uniprot

Rho GTPase activating protein 26 (Predicted)
type: ProteinReference
xref: uniprot D3ZMS4 671
xref: PTHR12552:SF4
organism: Rattus norvegicus

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 586

CoLlagen with Endostatin domain
type: ProteinReference
xref: uniprot G5EGA4 473
organism: Caenorhabditis elegans

uniprot P40792 696
type: UnificationXref
id: P40792
db: uniprot

uniprot E9HL06 1259
type: UnificationXref
id: E9HL06
db: uniprot

uniprot Q92569 950
type: UnificationXref
id: Q92569
db: uniprot

Integrin alpha-X
type: ProteinReference
xref: uniprot Q9QXH4 1085
xref: PTHR23220:SF118
organism: Mus musculus

uniprot A0A3Q1MDT9 412
type: UnificationXref
id: A0A3Q1MDT9
db: uniprot

uniprot P41350 350
type: UnificationXref
id: P41350
db: uniprot

Integrin beta
type: ProteinReference
xref: PTHR10082:SF9
xref: uniprot F1MVW3 768
organism: Bos taurus

uniprot Q5PQQ8 805
type: UnificationXref
id: Q5PQQ8
db: uniprot

Rho family GTPase 2
type: ProteinReference
xref: PTHR24072:SF21
xref: uniprot Q5HZE6 1294
organism: Rattus norvegicus

Collagen alpha-2(XI) chain
type: ProteinReference
xref: PTHR24023:SF509
xref: uniprot Q64739 562
organism: Mus musculus

uniprot I0FRT6 128
type: UnificationXref
id: I0FRT6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF393
xref: uniprot F7EFD0 48
organism: Monodelphis domestica

Collagen type IV alpha 4 chain
type: ProteinReference
xref: PTHR24023:SF714
xref: uniprot H2R630 487
organism: Pan troglodytes

ACTIVE 89
type: EntityFeature
comment: Active state

uniprot P08123 514
type: UnificationXref
id: P08123
db: uniprot

HETERODIMER ASSOCIATION LEFT Complex Integrin beta Integrin alpha Integrin beta Integrin alpha Collagen Laminin Fibronectin - Caveolin-RIGHT Complex Integrin beta Integrin alpha Caveolin Integrin alpha Integrin beta Collagen Laminin Fibronectin - r49
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 1516
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 1514
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 1515
left: Caveolin
left: Complex (Integrin beta/Integrin _alpha/ Integrin beta/Integrin _alpha/ Collagen/Laminin/ Fibronectin)
display name: HETERODIMER_ASSOCIATION_LEFT__Complex__Integrin_beta_Integrin__alpha__Integrin_beta_Integrin__alpha__Collagen_Laminin__Fibronectin_-_Caveolin-RIGHT__Complex__Integrin_beta_Integrin__alpha__Caveolin_Integrin__alpha__Integrin_beta_Collagen__Laminin_Fibronectin_-_r49
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Integrin beta/Integrin _alpha/ Caveolin/Integrin _alpha/ Integrin beta/Collagen/ Laminin/Fibronectin)

uniprot Q7ZVF9 1156
type: UnificationXref
id: Q7ZVF9
db: uniprot

alpha actinin s71 sa77 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha actinin
stoichiometric coefficient: 1.0

uniprot F6V4J5 719
type: UnificationXref
id: F6V4J5
db: uniprot

uniprot H2Q246 956
type: UnificationXref
id: H2Q246
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_r99
control type: ACTIVATION
controller: ?

RAP1A, member of RAS oncogene family
type: ProteinReference
xref: uniprot F6ZE26 40
xref: PTHR24070:SF393
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EP57 900
xref: PTHR10155:SF1
organism: Macaca mulatta

Integrin subunit alpha 4
type: ProteinReference
xref: uniprot D3ZMQ3 1007
xref: PTHR23220:SF78
organism: Rattus norvegicus

Collagen type XIV alpha 1 chain
type: ProteinReference
xref: uniprot E1BA17 426
xref: PTHR24020:SF15
organism: Bos taurus

uniprot P05625 637
type: UnificationXref
id: P05625
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot Q8BTI9 948
organism: Mus musculus

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 627
evidence: Evidence 625
evidence: Evidence 626
evidence: Evidence 624
xref: PTHR44329:SF22
xref: uniprot E2REI6 630
organism: Canis lupus familiaris

uniprot O18840 1135
type: UnificationXref
id: O18840
db: uniprot

uniprot Q3SYX9 236
type: UnificationXref
id: Q3SYX9
db: uniprot

uniprot F6UDX9 1128
type: UnificationXref
id: F6UDX9
db: uniprot

uniprot Q6SA80 1301
type: UnificationXref
id: Q6SA80
db: uniprot

uniprot Q6P7Z6 621
type: UnificationXref
id: Q6P7Z6
db: uniprot

uniprot O46404 919
type: UnificationXref
id: O46404
db: uniprot

Integrin subunit alpha 11
type: ProteinReference
xref: uniprot A0A2I3T5H5 1000
xref: PTHR23220:SF21
organism: Pan troglodytes

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot O09110 660
organism: Mus musculus

ncbitaxon 3702 618
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot Q61245 560
type: UnificationXref
id: Q61245
db: uniprot

ELMO2 isoform 11
type: ProteinReference
xref: PTHR12771:SF8
xref: uniprot H2QKI4 342
organism: Pan troglodytes

Integrin alpha-IIb
type: ProteinReference
xref: PTHR23220:SF73
xref: uniprot P08514 1051
organism: Homo sapiens

Crk
type: Protein
entity reference: Crk
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa18 1476
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot D3ZVF3 876
organism: Rattus norvegicus

ncbitaxon 9544 37
type: UnificationXref
id: 9544
db: ncbitaxon

Mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot F1PBB6 651
xref: PTHR48013:SF15
organism: Canis lupus familiaris

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P32871 928
organism: Bos taurus

Integrin alpha-PS5
type: ProteinReference
xref: PTHR23220:SF123
xref: uniprot Q9W1M8 1090
organism: Drosophila melanogaster

PTHR24055:SF222
type: RelationshipXref
id: PTHR24055:SF222
db: PANTHER Family
relationship type: By Homology

uniprot F1NYZ2 650
type: UnificationXref
id: F1NYZ2
db: uniprot

uniprot K7D0K0 495
type: UnificationXref
id: K7D0K0
db: uniprot

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 314

PTHR24418:SF373
type: RelationshipXref
id: PTHR24418:SF373
db: PANTHER Family
relationship type: By Homology

Alpha-actinin-1
type: ProteinReference
xref: PTHR11915:SF434
xref: uniprot P12814 731
organism: Homo sapiens

uniprot F7BBM1 897
type: UnificationXref
id: F7BBM1
db: uniprot

Paxillin
type: Protein
entity reference: Paxillin
feature: COMPLEX PARTICIPANT BINDING FEATURE s83 sa95 1510
feature: Paxillin s83 sa95 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q01149 543
type: UnificationXref
id: Q01149
db: uniprot

uniprot Q7QJR9 1241
type: UnificationXref
id: Q7QJR9
db: uniprot

uniprot P00523 988
type: UnificationXref
id: P00523
db: uniprot

uniprot Q9WTY9 164
type: UnificationXref
id: Q9WTY9
db: uniprot

uniprot O09110 660
type: UnificationXref
id: O09110
db: uniprot

PTHR12552:SF4
type: RelationshipXref
id: PTHR12552:SF4
db: PANTHER Family
relationship type: By Homology

PTHR12552:SF5
type: RelationshipXref
id: PTHR12552:SF5
db: PANTHER Family
relationship type: By Homology

uniprot O00329 913
type: UnificationXref
id: O00329
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot F6S8L5 1096
organism: Xenopus tropicalis

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 592

RND3 isoform 1
type: ProteinReference
xref: uniprot H2R6I3 1270
xref: PTHR24072:SF24
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F6YCI3 376
organism: Monodelphis domestica

Actinin alpha 4
type: ProteinReference
xref: uniprot A0A2I3STF2 708
xref: PTHR11915:SF425
organism: Pan troglodytes

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF162
xref: uniprot E9PT20 1173
organism: Rattus norvegicus

uniprot F1MXH6 105
type: UnificationXref
id: F1MXH6
db: uniprot

Ras-related protein rapA
type: ProteinReference
xref: PTHR24070:SF263
xref: uniprot P18613 60
organism: Dictyostelium discoideum

uniprot Q18823 1232
type: UnificationXref
id: Q18823
db: uniprot

Integrin alpha-1
type: ProteinReference
xref: uniprot P18614 1058
xref: PTHR23220:SF22
organism: Rattus norvegicus

uniprot B5DF98 97
type: UnificationXref
id: B5DF98
db: uniprot

Actinin alpha 4
type: ProteinReference
xref: uniprot E2R5T9 716
xref: PTHR11915:SF425
organism: Canis lupus familiaris

Integrin subunit alpha 8
type: ProteinReference
xref: uniprot F1PVR1 444
xref: PTHR23220:SF5
organism: Canis lupus familiaris

uniprot Q0III9 735
type: UnificationXref
id: Q0III9
db: uniprot

STATE_TRANSITION_LEFT__Cdc42-RIGHT__Cdc42-_r98
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r98 1578
participant stoichiometry: PARTICIPANT STOICHIOMETRY r98 1577
left: Cdc42
interaction type: STATE_TRANSITION
right: Cdc42

ILK s374 sa84 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ILK
stoichiometric coefficient: 1.0

uniprot A0A2I3TL93 202
type: UnificationXref
id: A0A2I3TL93
db: uniprot

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

Paxillin s23 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

uniprot P48736 933
type: UnificationXref
id: P48736
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot P14056 641
organism: Rattus norvegicus

uniprot H2QVX8 826
type: UnificationXref
id: H2QVX8
db: uniprot

uniprot F6VRJ5 720
type: UnificationXref
id: F6VRJ5
db: uniprot

PTHR24023:SF533
type: RelationshipXref
id: PTHR24023:SF533
db: PANTHER Family
relationship type: By Homology

PTHR24023:SF539
type: RelationshipXref
id: PTHR24023:SF539
db: PANTHER Family
relationship type: By Homology

GTP-binding protein RHO1
type: ProteinReference
xref: uniprot Q9HF54 1306
xref: PTHR24072:SF168
organism: Ashbya gossypii

uniprot F7EAN4 973
type: UnificationXref
id: F7EAN4
db: uniprot

uniprot P13944 523
type: UnificationXref
id: P13944
db: uniprot

STATE_TRANSITION_LEFT__Fyn-RIGHT__Fyn-_r88
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r88 1619
participant stoichiometry: PARTICIPANT STOICHIOMETRY r88 1620
left: Fyn
interaction type: STATE_TRANSITION
right: Fyn

GTPase NRas
type: ProteinReference
xref: uniprot P08556 310
xref: PTHR24070:SF189
organism: Mus musculus

uniprot E1B847 98
type: UnificationXref
id: E1B847
db: uniprot

Protein CBR-ATN-1
type: ProteinReference
xref: uniprot A8Y3R8 711
xref: PTHR11915:SF442
organism: Caenorhabditis briggsae

uniprot P12109 518
type: UnificationXref
id: P12109
db: uniprot

Collagen s12 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Collagen
stoichiometric coefficient: 1.0

uniprot O46037 957
type: UnificationXref
id: O46037
db: uniprot

PTHR24023:SF509
type: RelationshipXref
id: PTHR24023:SF509
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MLQ7 1104
xref: PTHR19981:SF7
organism: Bos taurus

ITGA6 isoform 6
type: ProteinReference
xref: PTHR23220:SF9
xref: uniprot A0A2I3TGE1 1002
organism: Pan troglodytes

uniprot O15143 225
type: UnificationXref
id: O15143
db: uniprot

uniprot Q61411 330
type: UnificationXref
id: Q61411
db: uniprot

ADP-ribosylation factor 1
type: ProteinReference
xref: uniprot P36579 604
xref: PTHR11711:SF30
organism: Schizosaccharomyces pombe

Uncharacterized protein
type: ProteinReference
xref: PTHR23220:SF26
xref: uniprot F7GPS1 1031
organism: Macaca mulatta

Collagen
type: Protein
entity reference: Collagen
feature: COMPLEX PARTICIPANT BINDING FEATURE s75 sa81 1470
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Vinculin
type: ProteinReference
xref: PTHR46180:SF1
xref: uniprot P12003 958
organism: Gallus gallus

uniprot Q61831 1346
type: UnificationXref
id: Q61831
db: uniprot

PTHR15036:SF47
type: RelationshipXref
id: PTHR15036:SF47
db: PANTHER Family
relationship type: By Homology

uniprot F6TR56 337
type: UnificationXref
id: F6TR56
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p130CAS-RIGHT__p130CAS-_r13
controller: FAK

Collagen, type IX, alpha 3
type: ProteinReference
xref: PTHR24023:SF866
xref: uniprot A2ACT7 414
organism: Mus musculus

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot A0JNB0 1092
organism: Bos taurus

uniprot A0A1D5QZP3 706
type: UnificationXref
id: A0A1D5QZP3
db: uniprot

Rho family GTPase 3
type: ProteinReference
xref: PTHR24072:SF24
xref: uniprot Q6DJ10 1297
organism: Xenopus tropicalis

Collagen alpha-2(IV) chain
type: ProteinReference
xref: PTHR24023:SF588
xref: uniprot P08572 515
organism: Homo sapiens

uniprot D4AB50 672
type: UnificationXref
id: D4AB50
db: uniprot

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot P39688 1099
organism: Mus musculus

Engulfment and cell motility 2
type: ProteinReference
xref: PTHR12771:SF8
xref: uniprot E2RF34 336
organism: Canis lupus familiaris

uniprot G3N3N1 363
type: UnificationXref
id: G3N3N1
db: uniprot

uniprot F1MMN6 1017
type: UnificationXref
id: F1MMN6
db: uniprot

uniprot Q3T0N5 148
type: UnificationXref
id: Q3T0N5
db: uniprot

Collagen type V alpha 2 chain
type: ProteinReference
xref: uniprot A0A3Q1MDT9 412
xref: PTHR24023:SF539
organism: Bos taurus

uniprot E2R4J1 1191
type: UnificationXref
id: E2R4J1
db: uniprot

Abl
type: Protein
entity reference: Abl
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7GE04 777
type: UnificationXref
id: F7GE04
db: uniprot

Complex (Abl/Paxillin)
type: Complex
component stoichiometry: Abl s82 sa94 STOICHIOMETRY ID COMPLEX
component stoichiometry: Paxillin s83 sa95 STOICHIOMETRY ID COMPLEX
component: Abl
component: Paxillin
feature: COMPLEX BINDING FEATURE s361 a569 1507
feature: COMPLEX BINDING FEATURE s361 a569 1509
cellular location: cytoplasm

Laminin subunit beta-4
type: ProteinReference
xref: PTHR10574:SF279
xref: uniprot A4D0S4 1185
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r102 1622
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

AGAP001874-PA
type: ProteinReference
xref: PTHR24070:SF263
xref: uniprot F5HMC8 32
organism: Anopheles gambiae

PARTICIPANT STOICHIOMETRY r102 1621
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

uniprot F7G4G7 467
type: UnificationXref
id: F7G4G7
db: uniprot

MEK
type: Protein
entity reference: MEK
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A8WWE8 203
type: UnificationXref
id: A8WWE8
db: uniprot

uniprot A8XNK9 418
type: UnificationXref
id: A8XNK9
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot E1BIM8 982
organism: Bos taurus

uniprot B1H230 648
type: UnificationXref
id: B1H230
db: uniprot

uniprot Q9ES46 1169
type: UnificationXref
id: Q9ES46
db: uniprot

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa15 1438
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A5D7F5 11
type: UnificationXref
id: A5D7F5
db: uniprot

Collagen alpha-1(VIII) chain
type: ProteinReference
xref: uniprot Q00780 542
xref: PTHR24023:SF903
organism: Mus musculus

uniprot Q3SWY2 858
type: UnificationXref
id: Q3SWY2
db: uniprot

uniprot O97902 180
type: UnificationXref
id: O97902
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot E2RMT4 207
xref: PTHR10709:SF10
organism: Canis lupus familiaris

Tyrosine-protein kinase fyna
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot Q6EWH2 1102
organism: Danio rerio

Talin
type: Protein
entity reference: Talin
feature: COMPLEX PARTICIPANT BINDING FEATURE s67 sa73 1460
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F1N7C3 371
xref: PTHR23113:SF168
organism: Bos taurus

uniprot Q80X90 276
type: UnificationXref
id: Q80X90
db: uniprot

uniprot P11046 1219
type: UnificationXref
id: P11046
db: uniprot

ncbitaxon 284812 605
type: UnificationXref
id: 284812
db: ncbitaxon

Paxillin s28 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

uniprot Q2KJ33 394
type: UnificationXref
id: Q2KJ33
db: uniprot

uniprot O70167 920
type: UnificationXref
id: O70167
db: uniprot

LIM domain-containing protein
type: ProteinReference
xref: uniprot Q8INQ9 396
organism: Drosophila melanogaster

uniprot Q14289 832
type: UnificationXref
id: Q14289
db: uniprot

uniprot H2R5K3 126
type: UnificationXref
id: H2R5K3
db: uniprot

Integrin beta
type: ProteinReference
xref: uniprot Q6P4X1 808
xref: PTHR10082:SF28
organism: Xenopus tropicalis

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot H2RBJ1 223
xref: PTHR12391:SF1
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot E2QTM5 23
organism: Canis lupus familiaris

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

uniprot H2QHJ6 52
type: UnificationXref
id: H2QHJ6
db: uniprot

uniprot Q6PHD6 859
type: UnificationXref
id: Q6PHD6
db: uniprot

PTHR10709:SF2
type: RelationshipXref
id: PTHR10709:SF2
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF109
type: RelationshipXref
id: PTHR10048:SF109
db: PANTHER Family
relationship type: By Homology

uniprot F6TUR3 1127
type: UnificationXref
id: F6TUR3
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 627
evidence: Evidence 625
evidence: Evidence 626
evidence: Evidence 624
xref: uniprot F7BRK5 632
xref: PTHR44329:SF22
organism: Monodelphis domestica

Uncharacterized protein rac1A
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot F1A084 690
organism: Dictyostelium purpureum

PARTICIPANT STOICHIOMETRY r49 1515
type: Stoichiometry
physical entity: Caveolin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r49 1516
type: Stoichiometry
physical entity: Complex (Integrin beta/Integrin _alpha/ Caveolin/Integrin _alpha/ Integrin beta/Collagen/ Laminin/Fibronectin)
stoichiometric coefficient: 1.0

uniprot F7AG99 458
type: UnificationXref
id: F7AG99
db: uniprot

AGAP009200-PA (Fragment)
type: ProteinReference
xref: uniprot Q7PVR8 566
organism: Anopheles gambiae

Alpha-parvin
type: ProteinReference
xref: PTHR12114:SF6
xref: uniprot Q9EPC1 1168
organism: Mus musculus

STATE_TRANSITION_LEFT__Arf1-RIGHT__Arf1-_r117
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r117 1560
participant stoichiometry: PARTICIPANT STOICHIOMETRY r117 1559
left: Arf1
interaction type: STATE_TRANSITION
right: Arf1

MODULATION
type: Control
xref: MODULATION
controlled: Actin polymerization
controller: Rac

uniprot Q9QWY8 187
type: UnificationXref
id: Q9QWY8
db: uniprot

Beta-actin-like protein 2
type: ProteinReference
xref: PTHR11937:SF168
xref: uniprot Q562R1 1150
organism: Homo sapiens

uniprot Q99759 162
type: UnificationXref
id: Q99759
db: uniprot

Actin-related protein 2/3 complex subunit 1A
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot Q9R0Q6 250
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r49 1514
type: Stoichiometry
physical entity: Complex (Integrin beta/Integrin _alpha/ Integrin beta/Integrin _alpha/ Collagen/Laminin/ Fibronectin)
stoichiometric coefficient: 1.0

uniprot Q91XD2 397
type: UnificationXref
id: Q91XD2
db: uniprot

PTHR24070:SF17
type: RelationshipXref
id: PTHR24070:SF17
db: PANTHER Family
relationship type: By Homology

uniprot F6SPW3 446
type: UnificationXref
id: F6SPW3
db: uniprot

Integrin beta-2
type: ProteinReference
xref: PTHR10082:SF15
xref: uniprot P05107 786
organism: Homo sapiens

Growth factor receptor-bound protein 2
type: ProteinReference
evidence: Evidence 194
xref: PTHR46037:SF4
xref: uniprot Q6PC73 193
organism: Danio rerio

uniprot F6Z0X3 1027
type: UnificationXref
id: F6Z0X3
db: uniprot

uniprot F1Q3M8 887
type: UnificationXref
id: F1Q3M8
db: uniprot

uniprot Q63932 668
type: UnificationXref
id: Q63932
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24023:SF604
xref: uniprot F6V7P3 450
organism: Macaca mulatta

Rho family GTPase 3a
type: ProteinReference
xref: uniprot Q6PC71 1300
xref: PTHR24072:SF24
organism: Danio rerio

uniprot Q8BHL5 344
type: UnificationXref
id: Q8BHL5
db: uniprot

uniprot F6Z0J4 896
type: UnificationXref
id: F6Z0J4
db: uniprot

PTHR11937:SF278
type: RelationshipXref
id: PTHR11937:SF278
db: PANTHER Family
relationship type: By Homology

uniprot P25318 532
type: UnificationXref
id: P25318
db: uniprot

uniprot F7HLW8 1033
type: UnificationXref
id: F7HLW8
db: uniprot

ncbitaxon 7739 592
type: UnificationXref
id: 7739
db: ncbitaxon

PTP-PEST
type: Protein
entity reference: PTP-PEST
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa26 1484
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 293

ADP-ribosylation factor 1
type: ProteinReference
xref: PTHR11711:SF30
xref: uniprot O00909 603
organism: Dictyostelium discoideum

uniprot O61861 229
type: UnificationXref
id: O61861
db: uniprot

Collagen alpha-3(V) chain
type: ProteinReference
xref: uniprot P25940 533
xref: PTHR24023:SF1023
organism: Homo sapiens

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot P06241 1098
organism: Homo sapiens

MAP2K4 isoform 3
type: ProteinReference
xref: uniprot H2QCA7 658
xref: PTHR48013:SF20
organism: Pan troglodytes

Collagen alpha-1(II) chain
type: ProteinReference
xref: PTHR24023:SF58
xref: uniprot Q6P4Z2 564
organism: Xenopus tropicalis

Shc s286 a420 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.02298445744145208
comment: MODIFICATION_RESIDUE_NAME=

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
type: ProteinReference
xref: PTHR10048:SF28
xref: uniprot Q61194 939
organism: Mus musculus

Rho GTPase-activating protein 10
type: ProteinReference
xref: PTHR12552:SF5
xref: uniprot Q6Y5D8 680
organism: Mus musculus

uniprot O08648 131
type: UnificationXref
id: O08648
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot F6PKK7 1095
organism: Macaca mulatta

uniprot F1PSC2 1105
type: UnificationXref
id: F1PSC2
db: uniprot

ncbitaxon 13616 46
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot P18206 959
type: UnificationXref
id: P18206
db: uniprot

PTHR23167:SF32
type: RelationshipXref
id: PTHR23167:SF32
db: PANTHER Family
relationship type: By Homology

Collagen alpha-2(VIII) chain
type: ProteinReference
xref: PTHR24023:SF1027
xref: uniprot P25067 531
organism: Homo sapiens

PTHR24023:SF588
type: RelationshipXref
id: PTHR24023:SF588
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QGA8 755
xref: PTHR10082:SF3
organism: Macaca mulatta

uniprot F7B6G0 721
type: UnificationXref
id: F7B6G0
db: uniprot

Collagen alpha-3(IX) chain
type: ProteinReference
xref: PTHR24023:SF866
xref: uniprot P32017 537
organism: Gallus gallus

uniprot P01119 307
type: UnificationXref
id: P01119
db: uniprot

uniprot F7EL30 723
type: UnificationXref
id: F7EL30
db: uniprot

uniprot A0A0G2JXT8 265
type: UnificationXref
id: A0A0G2JXT8
db: uniprot

CRK like proto-oncogene, adaptor protein
type: ProteinReference
xref: uniprot E2RF98 836
xref: PTHR19969:SF20
organism: Canis lupus familiaris

uniprot P27361 135
type: UnificationXref
id: P27361
db: uniprot

uniprot F6PZI2 1199
type: UnificationXref
id: F6PZI2
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot A0A0G2K344 862
xref: PTHR10048:SF107
organism: Rattus norvegicus

uniprot P02461 503
type: UnificationXref
id: P02461
db: uniprot

PXN isoform 9
type: ProteinReference
xref: uniprot A0A2I3SDP5 1320
xref: PTHR24216:SF11
organism: Pan troglodytes

PTHR23167:SF22
type: RelationshipXref
id: PTHR23167:SF22
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein phosphatase non-receptor type 12
type: ProteinReference
xref: PTHR45983:SF3
xref: uniprot Q05209 283
organism: Homo sapiens

Complex (Integrin beta/Integrin _alpha/ Paxillin/FAK/ Talin/Vinculin/ Actin/Integrin _alpha/ alpha actinin/Actin/ Integrin beta/Filamin/ Collagen/Laminin/ Fibronectin)
type: Complex
component stoichiometry: FAK s66 sa72 STOICHIOMETRY ID COMPLEX
component stoichiometry: Paxillin s65 sa71 STOICHIOMETRY ID COMPLEX
component stoichiometry: Complex ILK PINCH Parvin s373 a552 STOICHIOMETRY ID COMPLEX
component stoichiometry: Vinculin s68 sa74 STOICHIOMETRY ID COMPLEX
component stoichiometry: Laminin s76 sa82 STOICHIOMETRY ID COMPLEX
component stoichiometry: Actin s69 sa75 STOICHIOMETRY ID COMPLEX
component stoichiometry: Filamin s74 sa80 STOICHIOMETRY ID COMPLEX
component stoichiometry: Integrin beta s63 sa69 STOICHIOMETRY ID COMPLEX
component stoichiometry: Fibronectin s77 sa83 STOICHIOMETRY ID COMPLEX
component stoichiometry: Integrin alpha s64 sa70 STOICHIOMETRY ID COMPLEX
component stoichiometry: Talin s67 sa73 STOICHIOMETRY ID COMPLEX
component stoichiometry: Collagen s75 sa81 STOICHIOMETRY ID COMPLEX
component stoichiometry: alpha actinin s71 sa77 STOICHIOMETRY ID COMPLEX
component: Complex (ILK/PINCH/ Parvin)
component: FAK
component: Fibronectin
component: Integrin alpha
component: Talin
component: Filamin
component: Vinculin
component: alpha actinin
component: Collagen
component: Integrin beta
component: Actin
component: Paxillin
component: Laminin
feature: COMPLEX BINDING FEATURE s353 a546 1453
feature: COMPLEX BINDING FEATURE s353 a546 1467
feature: COMPLEX BINDING FEATURE s353 a546 1471
feature: COMPLEX BINDING FEATURE s353 a546 1449
feature: COMPLEX BINDING FEATURE s353 a546 1457
feature: COMPLEX BINDING FEATURE s353 a546 1455
feature: COMPLEX BINDING FEATURE s353 a546 1469
feature: COMPLEX BINDING FEATURE s353 a546 1473
feature: COMPLEX BINDING FEATURE s353 a546 1459
feature: COMPLEX BINDING FEATURE s353 a546 1461
feature: COMPLEX BINDING FEATURE s353 a546 1465
feature: COMPLEX BINDING FEATURE s353 a546 1451
feature: COMPLEX BINDING FEATURE s353 a546 1463
cellular location: cytoplasm

uniprot P54673 935
type: UnificationXref
id: P54673
db: uniprot

STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r31
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 1588
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 1589
left: PI3K
interaction type: STATE_TRANSITION
right: PI3K

Integrin alpha
type: Protein
entity reference: Integrin alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa14 1380
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR24072:SF24
type: RelationshipXref
id: PTHR24072:SF24
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein rasG
type: ProteinReference
xref: uniprot F0ZWE6 295
xref: PTHR24070:SF17
organism: Dictyostelium purpureum

PTHR24072:SF23
type: RelationshipXref
id: PTHR24072:SF23
db: PANTHER Family
relationship type: By Homology

PTHR24072:SF21
type: RelationshipXref
id: PTHR24072:SF21
db: PANTHER Family
relationship type: By Homology

PTHR24023:SF568
type: RelationshipXref
id: PTHR24023:SF568
db: PANTHER Family
relationship type: By Homology

PTHR24023:SF569
type: RelationshipXref
id: PTHR24023:SF569
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5ZIF0 152
xref: PTHR48013:SF5
organism: Gallus gallus

COL5A2 isoform 1
type: ProteinReference
xref: uniprot H2R6B8 488
xref: PTHR24023:SF539
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r110 1585
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36507 663
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36506 662
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r110 1584
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

uniprot H2Q9G3 123
type: UnificationXref
id: H2Q9G3
db: uniprot

uniprot E2RKA7 102
type: UnificationXref
id: E2RKA7
db: uniprot

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Ras-related protein Rap-1A
type: ProteinReference
xref: PTHR24070:SF395
xref: uniprot F7GH95 50
organism: Macaca mulatta

ITGAV isoform 1
type: ProteinReference
xref: PTHR23220:SF4
xref: uniprot H2R6C3 1044
organism: Pan troglodytes

Actin s32 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Actin
stoichiometric coefficient: 2.0

alpha actinin
type: Protein
entity reference: alpha actinin
feature: COMPLEX PARTICIPANT BINDING FEATURE s71 sa77 1466
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot D3ZFJ0 874
organism: Rattus norvegicus

uniprot P61227 67
type: UnificationXref
id: P61227
db: uniprot

Collagen type XIII alpha 1 chain
type: ProteinReference
xref: PTHR24023:SF871
xref: uniprot A0A0G2K2Q8 399
organism: Rattus norvegicus

Integrin alpha s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Integrin alpha
stoichiometric coefficient: 2.0

uniprot A9V489 1118
type: UnificationXref
id: A9V489
db: uniprot

uniprot O15511 228
type: UnificationXref
id: O15511
db: uniprot

ncbitaxon 7227 56
type: UnificationXref
id: 7227
db: ncbitaxon

PIP2 s88 sa97 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

Phosphatidylinositol 3-kinase vps34
type: ProteinReference
xref: uniprot P50520 934
xref: PTHR10048:SF7
organism: Schizosaccharomyces pombe

Laminin subunit alpha-5
type: ProteinReference
xref: PTHR10574:SF261
xref: uniprot Q61001 1236
organism: Mus musculus

MODULATION
type: Control
xref: MODULATION
controlled: Actin polymerization
controller: Cdc42

By Homology
type: RelationshipTypeVocabulary

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot P60766 966
organism: Mus musculus

uniprot Q9C3Y4 1304
type: UnificationXref
id: Q9C3Y4
db: uniprot

Integrin alpha-7
type: ProteinReference
xref: PTHR23220:SF90
xref: uniprot Q63258 1081
organism: Rattus norvegicus

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q9CPW4 247
xref: PTHR12644:SF1
organism: Mus musculus

SHC-transforming protein 1
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot Q5M824 1318
organism: Rattus norvegicus

uniprot Q28HZ4 1290
type: UnificationXref
id: Q28HZ4
db: uniprot

ADP-ribosylation factor 6
type: ProteinReference
xref: uniprot F6RLV0 358
xref: PTHR11711:SF379
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_r113
controller: GRAF

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r110
controller: Raf

uniprot Q16659 147
type: UnificationXref
id: Q16659
db: uniprot

Talin-1
type: ProteinReference
xref: uniprot Q9Y490 1112
xref: PTHR19981:SF7
organism: Homo sapiens

uniprot A0A3Q1LMM6 1160
type: UnificationXref
id: A0A3Q1LMM6
db: uniprot

Fibronectin s77 sa83 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fibronectin
stoichiometric coefficient: 1.0

Integrin beta-5
type: ProteinReference
xref: PTHR10082:SF26
xref: uniprot O70309 784
organism: Mus musculus

uniprot C3YC50 1120
type: UnificationXref
id: C3YC50
db: uniprot

uniprot Q05209 283
type: UnificationXref
id: Q05209
db: uniprot

Grb2 s15 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: uniprot P53349 140
organism: Mus musculus

uniprot P49187 139
type: UnificationXref
id: P49187
db: uniprot

Parvin beta
type: ProteinReference
xref: PTHR12114:SF7
xref: uniprot A0A2I3SCY3 1159
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r13 1532
type: Stoichiometry
physical entity: p130CAS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 1531
type: Stoichiometry
physical entity: p130CAS
stoichiometric coefficient: 1.0

PIP2
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q66JE6 158
xref: PTHR48013:SF5
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DTH8 722
xref: PTHR11915:SF425
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r41 1550
type: Stoichiometry
physical entity: Complex (Integrin beta/Integrin _alpha/ Integrin beta/Integrin _alpha/ Collagen/Laminin/ Fibronectin)
stoichiometric coefficient: 1.0

SHC-transforming protein 1
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot P29353 1315
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r87 1624
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r87 1623
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

Collagen
type: ProteinReference
xref: P00922
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Collagen
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Collagen alpha-6(IV) chain
member entity reference: Collagen alpha-1(XVII) chain
member entity reference: Collagen alpha-1(VIII) chain
member entity reference: Collagen type IV alpha 4 chain
member entity reference: Uncharacterized protein
member entity reference: Collagen alpha-1(III) chain
member entity reference: Collagen alpha-1(IV) chain
member entity reference: Collagen alpha-2(XI) chain
member entity reference: COL9A1 isoform 1
member entity reference: Collagen alpha-2(VI) chain
member entity reference: Collagen, type IX, alpha 3
member entity reference: Collagen type VIII alpha 2 chain
member entity reference: Collagen alpha-4(IV) chain
member entity reference: Collagen alpha-1(VI) chain
member entity reference: Collagen alpha-1(II) chain
member entity reference: COL20A1 isoform 3
member entity reference: Collagen type IX alpha 3 chain
member entity reference: Collagen alpha-1(IX) chain
member entity reference: COL5A2 isoform 1
member entity reference: Collagen alpha-2(V) chain
member entity reference: Collagen alpha-3(IV) chain
member entity reference: Integrin subunit alpha 8
member entity reference: Collagen type IV alpha 1 chain
member entity reference: Collagen type VI alpha 2 chain
member entity reference: COL13A1 isoform 3
member entity reference: Collagen alpha-3(VI) chain
member entity reference: COL9A3 isoform 2
member entity reference: Collagen alpha-1(XII) chain
member entity reference: Collagen type IX alpha 1 chain
member entity reference: Collagen type IX alpha 2 chain
member entity reference: ITGA8 isoform 1
member entity reference: Alpha 4 type V collagen
member entity reference: Collagen type IV alpha 5 chain
member entity reference: Col4a5 protein
member entity reference: Collagen alpha-2(I) chain
member entity reference: COL8A1 isoform 1
member entity reference: Collagen alpha-1(XVI) chain
member entity reference: Collagen, type I, alpha 2
member entity reference: Collagen alpha-2(IV) chain
member entity reference: Collagen alpha-1(XIII) chain
member entity reference: Collagen type XIV alpha 1 chain
member entity reference: Collagen type XI alpha 2 chain
member entity reference: Collagen type VI alpha 1 chain
member entity reference: Collagen, type IV, alpha 6
member entity reference: COL16A1 isoform 1

Laminin
type: Protein
entity reference: Laminin
feature: COMPLEX PARTICIPANT BINDING FEATURE s39 sa39 1434
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r87 1626
type: Stoichiometry
physical entity: Complex (SOS/Grb2/ Shc)
stoichiometric coefficient: 1.0

uniprot P62833 68
type: UnificationXref
id: P62833
db: uniprot

PARTICIPANT STOICHIOMETRY r87 1625
type: Stoichiometry
physical entity: Shc
stoichiometric coefficient: 1.0

Collagen type XVII alpha 1 chain
type: ProteinReference
xref: PTHR24023:SF891
xref: uniprot A0A1D5QEY1 403
organism: Macaca mulatta

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF0
xref: uniprot F6U132 212
organism: Monodelphis domestica

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot Q5R1X3 1153
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR11711:SF322
xref: uniprot E9HCC9 357
organism: Daphnia pulex

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YS73 271
xref: PTHR38537:SF7
organism: Macaca mulatta

uniprot Q99JI6 86
type: UnificationXref
id: Q99JI6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NAB9 437
xref: PTHR24020:SF39
organism: Gallus gallus

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot O15145 227
xref: PTHR12391:SF1
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r45 1535
type: Stoichiometry
physical entity: Complex (Integrin beta/Integrin _alpha/ Integrin beta/Integrin _alpha/ Collagen/Laminin/ Fibronectin)
stoichiometric coefficient: 1.0

PTHR24418:SF407
type: RelationshipXref
id: PTHR24418:SF407
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r45 1533
type: Stoichiometry
physical entity: Complex (Integrin beta/Integrin _alpha)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 1534
type: Stoichiometry
physical entity: Complex (Fibronectin/Laminin/ Collagen)
stoichiometric coefficient: 1.0

uniprot Q58CQ2 239
type: UnificationXref
id: Q58CQ2
db: uniprot

uniprot H2R828 780
type: UnificationXref
id: H2R828
db: uniprot

PARTICIPANT STOICHIOMETRY r41 1553
type: Stoichiometry
physical entity: Complex (Integrin _alpha/Paxillin/ Integrin beta/Talin/ Vinculin/Actin/ Integrin _alpha/alpha actinin/ Actin/Integrin beta/ Filamin/Collagen/ Laminin/Fibronectin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r41 1551
type: Stoichiometry
physical entity: Talin
stoichiometric coefficient: 1.0

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: uniprot O15143 225
xref: PTHR10709:SF10
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r41 1552
type: Stoichiometry
physical entity: Complex (Vinculin/Actin)
stoichiometric coefficient: 1.0

uniprot F1LNH3 430
type: UnificationXref
id: F1LNH3
db: uniprot

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: PTHR12058:SF0
xref: uniprot O15144 226
organism: Homo sapiens

Integrin subunit alpha 2b
type: ProteinReference
xref: PTHR23220:SF73
xref: uniprot H2QD72 1039
organism: Pan troglodytes

uniprot P08648 1052
type: UnificationXref
id: P08648
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot F6PVY4 210
xref: PTHR10709:SF11
organism: Macaca mulatta

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot Q8CFN2 971
organism: Rattus norvegicus

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot Q1RMJ6 1287
organism: Bos taurus

uniprot D4ADG9 425
type: UnificationXref
id: D4ADG9
db: uniprot

uniprot P49134 799
type: UnificationXref
id: P49134
db: uniprot

Integrin beta
type: ProteinReference
xref: P00931
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Integrin_br__beta_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Integrin beta
member entity reference: Integrin beta-1
member entity reference: Integrin beta-nu
member entity reference: Integrin beta-5
member entity reference: Integrin subunit beta like 1
member entity reference: Integrin beta-like protein 1
member entity reference: Integrin beta-3
member entity reference: Integrin beta pat-3
member entity reference: Integrin beta-6
member entity reference: Integrin beta-2
member entity reference: Integrin beta-7
member entity reference: Integrin beta-2-like protein
member entity reference: Integrin beta-PS
member entity reference: Integrin beta (Fragment)
member entity reference: Integrin beta-8
member entity reference: Integrin beta-4
member entity reference: Uncharacterized protein
member entity reference: ITGBL1 isoform 2

uniprot A0A2I3TFS6 1001
type: UnificationXref
id: A0A2I3TFS6
db: uniprot

uniprot F1QV75 597
type: UnificationXref
id: F1QV75
db: uniprot

uniprot Q8WQG9 1347
type: UnificationXref
id: Q8WQG9
db: uniprot

Alpha-actinin-4
type: ProteinReference
xref: PTHR11915:SF425
xref: uniprot O43707 727
organism: Homo sapiens

uniprot F6SZ66 890
type: UnificationXref
id: F6SZ66
db: uniprot

uniprot P11276 979
type: UnificationXref
id: P11276
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12114:SF6
xref: uniprot F7CCU2 1165
organism: Monodelphis domestica

Caveolin
type: ProteinReference
xref: P00918
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Caveolin
comment: ENTITY_REFERENCE_NOTES=Long Name: Caveolin Synonym: Synonym not specified Accession: P00918
member entity reference: Caveolin-1
member entity reference: Caveolin

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot F6VAQ8 892
organism: Ornithorhynchus anatinus

uniprot F6PVY4 210
type: UnificationXref
id: F6PVY4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r102
controller: Complex (p130CAS/Crk/ Dock180/ELMO)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot A0A2I3T7A8 868
xref: PTHR10048:SF107
organism: Pan troglodytes

Y397 FAK s134 a146 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y397
feature location: Y397 FAK s134 a146 rs1 Y397
comment: MODIFICATION_RESIDUE_NAME=Y397
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4400218803743385

Rho
type: Protein
entity reference: Rho
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P49186 1343
organism: Rattus norvegicus

uniprot P08645 57
type: UnificationXref
id: P08645
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot P49187 139
organism: Rattus norvegicus

uniprot G5EEN3 751
type: UnificationXref
id: G5EEN3
db: uniprot

uniprot Q96JJ3 347
type: UnificationXref
id: Q96JJ3
db: uniprot

uniprot F7FDA0 902
type: UnificationXref
id: F7FDA0
db: uniprot

uniprot H2Q2R7 752
type: UnificationXref
id: H2Q2R7
db: uniprot

uniprot O35904 918
type: UnificationXref
id: O35904
db: uniprot

Integrin beta
type: ProteinReference
xref: uniprot A0A2I3SCU5 759
xref: PTHR10082:SF36
organism: Pan troglodytes

Integrin alpha-M
type: ProteinReference
xref: uniprot P11215 1053
xref: PTHR23220:SF130
organism: Homo sapiens

uniprot A0A2I3TJQ1 709
type: UnificationXref
id: A0A2I3TJQ1
db: uniprot

Adapter molecule crk
type: ProteinReference
xref: uniprot Q64010 846
xref: PTHR19969:SF8
organism: Mus musculus

DnaJ homolog subfamily C member 27
type: ProteinReference
xref: uniprot Q8CFP6 85
organism: Mus musculus

uniprot E2R9L4 101
type: UnificationXref
id: E2R9L4
db: uniprot

uniprot H2QB02 1038
type: UnificationXref
id: H2QB02
db: uniprot

uniprot G8CYZ7 341
type: UnificationXref
id: G8CYZ7
db: uniprot

PARTICIPANT STOICHIOMETRY r41 1548
type: Stoichiometry
physical entity: Filamin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r41 1549
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

PTHR10337:SF11
type: RelationshipXref
id: PTHR10337:SF11
db: PANTHER Family
relationship type: By Homology

uniprot Q9CPW4 247
type: UnificationXref
id: Q9CPW4
db: uniprot

uniprot H2R630 487
type: UnificationXref
id: H2R630
db: uniprot

LIM and senescent cell antigen-like-containing domain protein 2
type: ProteinReference
xref: PTHR24210:SF10
xref: uniprot Q91XD2 397
organism: Mus musculus

uniprot Q6ID97 617
type: UnificationXref
id: Q6ID97
db: uniprot

PARTICIPANT STOICHIOMETRY r41 1547
type: Stoichiometry
physical entity: Complex (alpha actinin/Actin)
stoichiometric coefficient: 1.0

uniprot K7ALD7 303
type: UnificationXref
id: K7ALD7
db: uniprot

uniprot F7BWW9 377
type: UnificationXref
id: F7BWW9
db: uniprot

uniprot Q7Z4I7 395
type: UnificationXref
id: Q7Z4I7
db: uniprot

Laminin subunit gamma-3
type: ProteinReference
xref: PTHR10574:SF240
xref: uniprot Q9R0B6 1246
organism: Mus musculus

uniprot Q6DJ10 1297
type: UnificationXref
id: Q6DJ10
db: uniprot

uniprot Q7ZVI7 1157
type: UnificationXref
id: Q7ZVI7
db: uniprot

PARTICIPANT STOICHIOMETRY r36 1564
type: Stoichiometry
physical entity: p130CAS
stoichiometric coefficient: 1.0

uniprot H2R8L2 1314
type: UnificationXref
id: H2R8L2
db: uniprot

uniprot F1MJR6 433
type: UnificationXref
id: F1MJR6
db: uniprot

uniprot E2RS61 1258
type: UnificationXref
id: E2RS61
db: uniprot

PARTICIPANT STOICHIOMETRY r36 1563
type: Stoichiometry
physical entity: p130CAS
stoichiometric coefficient: 1.0

uniprot P68138 1147
type: UnificationXref
id: P68138
db: uniprot

Integrin beta-1
type: ProteinReference
xref: uniprot P49134 799
xref: PTHR10082:SF28
organism: Rattus norvegicus

uniprot E9GYE9 963
type: UnificationXref
id: E9GYE9
db: uniprot

uniprot Q62925 156
type: UnificationXref
id: Q62925
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 8

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FAK-RIGHT__FAK-_r10
controller: Src

Fibronectin
type: ProteinReference
xref: uniprot P04937 977
xref: PTHR19143:SF267
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r109
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r109 1601
participant stoichiometry: PARTICIPANT STOICHIOMETRY r109 1600
left: Raf
interaction type: STATE_TRANSITION
right: Raf

Paxillin s83 sa95 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F7HU82 725
type: UnificationXref
id: F7HU82
db: uniprot

ADP-ribosylation factor 2
type: ProteinReference
xref: uniprot Q6NYD8 620
xref: PTHR11711:SF30
organism: Danio rerio

Ras-related protein Rap-1b
type: ProteinReference
xref: PTHR24070:SF393
xref: uniprot Q5ZHX1 75
organism: Gallus gallus

Fibronectin
type: ProteinReference
xref: uniprot P11276 979
xref: PTHR19143:SF267
organism: Mus musculus

uniprot F1R684 31
type: UnificationXref
id: F1R684
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF395
xref: uniprot F1NSA8 29
organism: Gallus gallus

uniprot F6Z5N3 298
type: UnificationXref
id: F6Z5N3
db: uniprot

uniprot P45984 1342
type: UnificationXref
id: P45984
db: uniprot

Integrin beta
type: ProteinReference
xref: uniprot A0A2I3TPM4 762
xref: PTHR10082:SF15
organism: Pan troglodytes

uniprot H2R193 484
type: UnificationXref
id: H2R193
db: uniprot

uniprot Q8IZC6 569
type: UnificationXref
id: Q8IZC6
db: uniprot

PARTICIPANT STOICHIOMETRY r104 1611
type: Stoichiometry
physical entity: Rap1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r104 1610
type: Stoichiometry
physical entity: Rap1
stoichiometric coefficient: 1.0

Rho-related GTP-binding protein RhoA-B
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot Q6DHM9 1296
organism: Danio rerio

RCG51408
type: ProteinReference
xref: PTHR12552:SF5
xref: uniprot D4AB50 672
organism: Rattus norvegicus

uniprot P42339 932
type: UnificationXref
id: P42339
db: uniprot

Actopaxin
type: ProteinReference
xref: PTHR12114:SF6
xref: uniprot Q6DRM4 1167
organism: Danio rerio

Crk s79 sa91 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Crk
stoichiometric coefficient: 1.0

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 22

Uncharacterized protein
type: ProteinReference
xref: uniprot E9HL06 1259
xref: PTHR24072:SF168
organism: Daphnia pulex

Integrin alpha-3
type: ProteinReference
xref: PTHR23220:SF89
xref: uniprot F1MMS9 1018
organism: Bos taurus

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot H9FU32 633
organism: Macaca mulatta

ADP-ribosylation factor 1
type: ProteinReference
xref: uniprot Q803D1 622
xref: PTHR11711:SF30
organism: Danio rerio

COL9A1 isoform 1
type: ProteinReference
xref: PTHR24023:SF918
xref: uniprot A0A2I3TWJ5 409
organism: Pan troglodytes

Actin
type: ProteinReference
xref: uniprot E3K4I1 1122
xref: PTHR11937:SF387
organism: Puccinia graminis

uniprot F1NN08 596
type: UnificationXref
id: F1NN08
db: uniprot

uniprot H9FYU7 379
type: UnificationXref
id: H9FYU7
db: uniprot

uniprot P39059 538
type: UnificationXref
id: P39059
db: uniprot

uniprot H2RBJ1 223
type: UnificationXref
id: H2RBJ1
db: uniprot

uniprot H2QLM8 726
type: UnificationXref
id: H2QLM8
db: uniprot

uniprot A0A0G2KAE1 386
type: UnificationXref
id: A0A0G2KAE1
db: uniprot

uniprot P34145 693
type: UnificationXref
id: P34145
db: uniprot

uniprot F6QBF0 1164
type: UnificationXref
id: F6QBF0
db: uniprot

LIM and senescent cell antigen-like-containing domain protein 1
type: ProteinReference
xref: PTHR24210:SF11
xref: uniprot P48059 393
organism: Homo sapiens

uniprot E2RF98 836
type: UnificationXref
id: E2RF98
db: uniprot

uniprot A7MB18 1186
type: UnificationXref
id: A7MB18
db: uniprot

Ras-related protein Rap-1b
type: ProteinReference
xref: PTHR24070:SF393
xref: uniprot Q62636 76
organism: Rattus norvegicus

uniprot Q6IML7 78
type: UnificationXref
id: Q6IML7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF24
xref: uniprot R4GI31 1312
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r116 1562
type: Stoichiometry
physical entity: ASAP1
stoichiometric coefficient: 1.0

uniprot P41241 263
type: UnificationXref
id: P41241
db: uniprot

PARTICIPANT STOICHIOMETRY r116 1561
type: Stoichiometry
physical entity: ASAP1
stoichiometric coefficient: 1.0

MICAL-like 1
type: ProteinReference
xref: uniprot H2QLM8 726
organism: Pan troglodytes

uniprot P13612 1056
type: UnificationXref
id: P13612
db: uniprot

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot Q02384 382
xref: PTHR23113:SF150
organism: Mus musculus

Laminin s39 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Laminin
stoichiometric coefficient: 1.0

IDA
type: EvidenceCodeVocabulary

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF0
xref: uniprot Q9VX82 253
organism: Drosophila melanogaster

Predicted protein
type: ProteinReference
xref: uniprot A9V489 1118
xref: PTHR11937:SF387
organism: Monosiga brevicollis

uniprot H3BM21 781
type: UnificationXref
id: H3BM21
db: uniprot

ncbitaxon 418459 1123
type: UnificationXref
id: 418459
db: ncbitaxon

uniprot Q9QUM0 1084
type: UnificationXref
id: Q9QUM0
db: uniprot

Ras-related protein R-Ras
type: ProteinReference
xref: uniprot P10833 316
xref: PTHR24070:SF245
organism: Mus musculus

uniprot Q8R4I6 741
type: UnificationXref
id: Q8R4I6
db: uniprot

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot P60710 1139
xref: PTHR11937:SF192
organism: Mus musculus

uniprot P10114 58
type: UnificationXref
id: P10114
db: uniprot

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot P60711 1140
organism: Rattus norvegicus

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot P60712 1141
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r20 1629
type: Stoichiometry
physical entity: p130CAS
stoichiometric coefficient: 1.0

uniprot K7ARM1 491
type: UnificationXref
id: K7ARM1
db: uniprot

uniprot P12107 517
type: UnificationXref
id: P12107
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6VXG1 893
xref: PTHR10048:SF107
organism: Xenopus tropicalis

BCAR1, Cas family scaffold protein
type: ProteinReference
xref: uniprot F1P9X8 170
xref: PTHR10654:SF15
organism: Canis lupus familiaris

uniprot Q01986 144
type: UnificationXref
id: Q01986
db: uniprot

Paxillin
type: ProteinReference
xref: PTHR24216:SF11
xref: uniprot F7B727 1321
organism: Xenopus tropicalis

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot P60709 1138
xref: PTHR11937:SF192
organism: Homo sapiens

uniprot Q9PSX7 1309
type: UnificationXref
id: Q9PSX7
db: uniprot

uniprot K7CW85 304
type: UnificationXref
id: K7CW85
db: uniprot

uniprot Q13751 1228
type: UnificationXref
id: Q13751
db: uniprot

Parvin
type: ProteinReference
xref: P00945
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Parvin
member entity reference: Uncharacterized protein
member entity reference: Parvin beta
member entity reference: Alpha-parvin
member entity reference: Beta-parvin
member entity reference: Parvin alpha
member entity reference: Actopaxin
member entity reference: Parvin, beta

uniprot C3YJC1 684
type: UnificationXref
id: C3YJC1
db: uniprot

uniprot F1N169 269
type: UnificationXref
id: F1N169
db: uniprot

uniprot F7DWL1 1107
type: UnificationXref
id: F7DWL1
db: uniprot

PARTICIPANT STOICHIOMETRY r20 1630
type: Stoichiometry
physical entity: C3G
stoichiometric coefficient: 1.0

Integrin-linked protein kinase
type: ProteinReference
xref: uniprot Q13418 857
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r20 1632
type: Stoichiometry
physical entity: Complex (Crk/C3G/ p130CAS)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 1631
type: Stoichiometry
physical entity: Crk
stoichiometric coefficient: 1.0

uniprot F7H9J1 121
type: UnificationXref
id: F7H9J1
db: uniprot

uniprot Q9TU25 705
type: UnificationXref
id: Q9TU25
db: uniprot

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P01111 305
organism: Homo sapiens

GTPase HRas
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot P01112 306
organism: Homo sapiens

Complex (Integrin beta/Integrin _alpha)
type: Complex
component stoichiometry: Integrin alpha s14 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: Integrin beta s13 sa8 STOICHIOMETRY ID COMPLEX
component: Integrin alpha
component: Integrin beta
feature: COMPLEX BINDING FEATURE s6 a8 1379
feature: COMPLEX BINDING FEATURE s6 a8 1377
cellular location: cytoplasm

uniprot P08642 311
type: UnificationXref
id: P08642
db: uniprot

uniprot Q9V3C8 1319
type: UnificationXref
id: Q9V3C8
db: uniprot

PTHR24418:SF78
type: RelationshipXref
id: PTHR24418:SF78
db: PANTHER Family
relationship type: By Homology

uniprot Q553U6 1149
type: UnificationXref
id: Q553U6
db: uniprot

Integrin beta
type: ProteinReference
xref: PTHR10082:SF28
xref: uniprot A0A2I3RYR8 757
organism: Pan troglodytes

uniprot F7GPS1 1031
type: UnificationXref
id: F7GPS1
db: uniprot

uniprot Q05306 548
type: UnificationXref
id: Q05306
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A0A2I3RZ31 94
organism: Pan troglodytes

uniprot F7GWI9 468
type: UnificationXref
id: F7GWI9
db: uniprot

uniprot Q9UKX5 1088
type: UnificationXref
id: Q9UKX5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot E2RLH2 1257
organism: Canis lupus familiaris

PI3K
type: ProteinReference
xref: P00936
standard name: Phosphatidylinositol 3-kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphatidylinositol-3-kinase Synonym: PI3-K Accession: P00936
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.PI3K
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit gamma
member entity reference: Phosphatidylinositol 3-kinase piki-1
member entity reference: Phosphatidylinositol 3-kinase catalytic subunit type 3
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
member entity reference: Pi3K21B, isoform B
member entity reference: AGAP000018-PA
member entity reference: Phosphatidylinositol 3-kinase VPS34
member entity reference: PIK3C2A isoform 5
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit beta
member entity reference: Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
member entity reference: Phosphatidylinositol 3-kinase age-1
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
member entity reference: Phosphoinositide-3-kinase regulatory subunit 3
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
member entity reference: Phosphoinositide-3-kinase regulatory subunit 1
member entity reference: Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
member entity reference: PIK3R1 isoform 1
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha
member entity reference: Phosphoinositide-3-kinase regulatory subunit 2
member entity reference: PI-3 kinase
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
member entity reference: AGAP011036-PA (Fragment)
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
member entity reference: Phosphatidylinositol 3-kinase 3
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
member entity reference: Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a
member entity reference: Phosphatidylinositol 3-kinase vps34
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol 3-kinase 2

uniprot F7DIB7 1132
type: UnificationXref
id: F7DIB7
db: uniprot

Abl
type: Protein
entity reference: Abl
feature: COMPLEX PARTICIPANT BINDING FEATURE s82 sa94 1508
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Proto-oncogene tyrosine-protein kinase Src
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot P12931 991
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ASAP1-RIGHT__ASAP1-_r116
controller: FAK

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q91Y86 1348
xref: PTHR24055:SF222
organism: Mus musculus

Shc s86 sa66 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Shc
stoichiometric coefficient: 1.0

uniprot Q5AND9 614
type: UnificationXref
id: Q5AND9
db: uniprot

uniprot A0A1D5NYG3 266
type: UnificationXref
id: A0A1D5NYG3
db: uniprot

uniprot Q08DP6 678
type: UnificationXref
id: Q08DP6
db: uniprot

Integrin beta-like protein 1
type: ProteinReference
xref: uniprot O95965 785
xref: PTHR10082:SF3
organism: Homo sapiens

ADP-ribosylation factor 1
type: ProteinReference
xref: uniprot P84079 611
xref: PTHR11711:SF357
organism: Rattus norvegicus

ADP-ribosylation factor 1
type: ProteinReference
xref: PTHR11711:SF357
xref: uniprot P84078 610
organism: Mus musculus

uniprot P79132 352
type: UnificationXref
id: P79132
db: uniprot

Vinculin
type: ProteinReference
xref: uniprot O46037 957
xref: PTHR46180:SF1
organism: Drosophila melanogaster

ADP-ribosylation factor 1
type: ProteinReference
xref: PTHR11711:SF357
xref: uniprot P84077 609
organism: Homo sapiens

uniprot Q9R0Q6 250
type: UnificationXref
id: Q9R0Q6
db: uniprot

PTHR24418:SF94
type: RelationshipXref
id: PTHR24418:SF94
db: PANTHER Family
relationship type: By Homology

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 588

uniprot Q29RC5 699
type: UnificationXref
id: Q29RC5
db: uniprot

Laminin subunit gamma 2
type: ProteinReference
xref: PTHR10574:SF313
xref: uniprot F1LRH4 1193
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r78 1530
type: Stoichiometry
physical entity: Complex (p130CAS/Crk/ Dock180/ELMO)
stoichiometric coefficient: 1.0

B-Raf
type: Protein
entity reference: B-Raf
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot H2PZU1 1035
type: UnificationXref
id: H2PZU1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7C2C6 117
xref: PTHR24055:SF171
organism: Monodelphis domestica

uniprot Q13349 1072
type: UnificationXref
id: Q13349
db: uniprot

Integrin alpha-D
type: ProteinReference
xref: PTHR23220:SF19
xref: uniprot Q13349 1072
organism: Homo sapiens

uniprot Q61739 1078
type: UnificationXref
id: Q61739
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10574:SF285
xref: uniprot F6ZDE9 1201
organism: Macaca mulatta

DShc protein
type: ProteinReference
xref: uniprot Q9V3C8 1319
xref: PTHR10337:SF11
organism: Drosophila melanogaster

uniprot Q13797 1074
type: UnificationXref
id: Q13797
db: uniprot

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot Q9PSX7 1309
organism: Gallus gallus

Integrin beta
type: ProteinReference
xref: PTHR10082:SF25
xref: uniprot F6SRR1 773
organism: Xenopus tropicalis

Complex (Vinculin/PIP2/ Arp2/3)
type: Complex
component stoichiometry: PIP2 s88 sa97 STOICHIOMETRY ID COMPLEX
component stoichiometry: Arp2 3 s89 sa98 STOICHIOMETRY ID COMPLEX
component stoichiometry: Vinculin s87 sa96 STOICHIOMETRY ID COMPLEX
component: Arp2/3
component: Vinculin
component: PIP2
feature: COMPLEX BINDING FEATURE s368 a617 1503
feature: COMPLEX BINDING FEATURE s368 a617 1505
feature: COMPLEX BINDING FEATURE s368 a617 1501
cellular location: cytoplasm

Filamin s74 sa80 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Filamin
stoichiometric coefficient: 1.0

uniprot Q9XSJ7 580
type: UnificationXref
id: Q9XSJ7
db: uniprot

uniprot F1PPG5 770
type: UnificationXref
id: F1PPG5
db: uniprot

Integrin alpha 5 (Mapped)
type: ProteinReference
xref: uniprot A0A0G2K1E2 996
xref: PTHR23220:SF3
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r78 1529
type: Stoichiometry
physical entity: Crk
stoichiometric coefficient: 1.0

ADP-ribosylation factor 1
type: ProteinReference
xref: uniprot P84080 612
xref: PTHR11711:SF357
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r78 1528
type: Stoichiometry
physical entity: ELMO
stoichiometric coefficient: 1.0

GTP-binding protein rho5
type: ProteinReference
xref: uniprot Q9HE04 1305
xref: PTHR24072:SF168
organism: Schizosaccharomyces pombe

uniprot F7EP57 900
type: UnificationXref
id: F7EP57
db: uniprot

PARTICIPANT STOICHIOMETRY r78 1527
type: Stoichiometry
physical entity: Dock180
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r78 1526
type: Stoichiometry
physical entity: p130CAS
stoichiometric coefficient: 1.0

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
type: ProteinReference
xref: uniprot Q9QWY8 187
organism: Mus musculus

uniprot Q6DGK1 616
type: UnificationXref
id: Q6DGK1
db: uniprot

uniprot F6U702 848
type: UnificationXref
id: F6U702
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r94
control type: ACTIVATION
controller: ?

uniprot A0A3Q1N3A0 1183
type: UnificationXref
id: A0A3Q1N3A0
db: uniprot

uniprot P56945 171
type: UnificationXref
id: P56945
db: uniprot

PTHR24072:SF310
type: RelationshipXref
id: PTHR24072:SF310
db: PANTHER Family
relationship type: By Homology

uniprot Q9Z1P2 744
type: UnificationXref
id: Q9Z1P2
db: uniprot

uniprot F7CZP3 1264
type: UnificationXref
id: F7CZP3
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 605

Ashbya gossypii
type: BioSource
xref: ncbitaxon 284811 1307

Laminin s56 sa62 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Laminin
stoichiometric coefficient: 1.0

uniprot Q04982 200
type: UnificationXref
id: Q04982
db: uniprot

uniprot F6W7C8 894
type: UnificationXref
id: F6W7C8
db: uniprot

uniprot F7B3R3 460
type: UnificationXref
id: F7B3R3
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P26450 926
organism: Mus musculus

uniprot P61226 65
type: UnificationXref
id: P61226
db: uniprot

Actinin alpha 1
type: ProteinReference
xref: PTHR11915:SF434
xref: uniprot F7B6G0 721
organism: Xenopus tropicalis

PTHR24023:SF604
type: RelationshipXref
id: PTHR24023:SF604
db: PANTHER Family
relationship type: By Homology

HRAS isoform 2
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot K7ALD7 303
organism: Pan troglodytes

uniprot P27704 137
type: UnificationXref
id: P27704
db: uniprot

PTHR24216:SF8
type: RelationshipXref
id: PTHR24216:SF8
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF221
xref: uniprot E1BQI2 21
organism: Gallus gallus

uniprot P60712 1141
type: UnificationXref
id: P60712
db: uniprot

uniprot Q5FVG9 1293
type: UnificationXref
id: Q5FVG9
db: uniprot

uniprot D3ZQN7 1187
type: UnificationXref
id: D3ZQN7
db: uniprot

PTHR24418:SF44
type: RelationshipXref
id: PTHR24418:SF44
db: PANTHER Family
relationship type: By Homology

uniprot P07228 788
type: UnificationXref
id: P07228
db: uniprot

uniprot Q3ZC55 738
type: UnificationXref
id: Q3ZC55
db: uniprot

VASP
type: ProteinReference
xref: P00934
standard name: Vasodilator-stimulated phosphoprotein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Vasodilator-stimulated phosphoprotein Synonym: VASP,Vasodilator-stimulated phosphoprotein Accession: P00934
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.VASP
member entity reference: Vasodilator-stimulated phosphoprotein
member entity reference: Uncharacterized protein

Y397 FAK s66 sa72 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y397
feature location: Y397 FAK s66 sa72 rs1 Y397
comment: MODIFICATION_RESIDUE_NAME=Y397
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4400218803743385

uniprot E2RMT4 207
type: UnificationXref
id: E2RMT4
db: uniprot

uniprot P12003 958
type: UnificationXref
id: P12003
db: uniprot

uniprot Q3U962 557
type: UnificationXref
id: Q3U962
db: uniprot

PTHR24418:SF53
type: RelationshipXref
id: PTHR24418:SF53
db: PANTHER Family
relationship type: By Homology

uniprot P12931 991
type: UnificationXref
id: P12931
db: uniprot

Integrin beta-1
type: ProteinReference
xref: PTHR10082:SF28
xref: uniprot P09055 789
organism: Mus musculus

uniprot F1P1K3 208
type: UnificationXref
id: F1P1K3
db: uniprot

Jnk
type: Protein
entity reference: Jnk
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot E2RFF7 256
type: UnificationXref
id: E2RFF7
db: uniprot

uniprot O93468 1274
type: UnificationXref
id: O93468
db: uniprot

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 582

uniprot P15988 524
type: UnificationXref
id: P15988
db: uniprot

uniprot Q5ZIF0 152
type: UnificationXref
id: Q5ZIF0
db: uniprot

uniprot F1PRU9 1021
type: UnificationXref
id: F1PRU9
db: uniprot

uniprot Q3UV74 804
type: UnificationXref
id: Q3UV74
db: uniprot

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: uniprot H2R5K3 126
organism: Pan troglodytes

Ras-like protein 2
type: ProteinReference
xref: PTHR24070:SF17
xref: uniprot P01120 309
organism: Saccharomyces cerevisiae

uniprot P00520 1174
type: UnificationXref
id: P00520
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24023:SF533
xref: uniprot F7EQ13 465
organism: Macaca mulatta

COL1A1 isoform 2
type: ProteinReference
xref: PTHR24023:SF569
xref: uniprot H2QDE6 476
organism: Pan troglodytes

Integrin subunit alpha 3
type: ProteinReference
xref: uniprot H2QDE3 1040
xref: PTHR23220:SF89
organism: Pan troglodytes

Actin-related protein 2/3 complex subunit 5-like protein
type: ProteinReference
xref: uniprot Q5E963 240
xref: PTHR12644:SF2
organism: Bos taurus

uniprot F7F3K9 775
type: UnificationXref
id: F7F3K9
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6TXC2 111
organism: Monodelphis domestica

Y397 FAK s181 a240 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y397
feature location: Y397 FAK s181 a240 rs1 Y397
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y397
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4400218803743385

Ras-like protein 1
type: ProteinReference
xref: PTHR24070:SF17
xref: uniprot P01119 307
organism: Saccharomyces cerevisiae

uniprot A0A2I3SZX7 760
type: UnificationXref
id: A0A2I3SZX7
db: uniprot

PTHR24418:SF431
type: RelationshipXref
id: PTHR24418:SF431
db: PANTHER Family
relationship type: By Homology

PTHR24418:SF430
type: RelationshipXref
id: PTHR24418:SF430
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot F6S9S9 654
organism: Monodelphis domestica

ncbitaxon 237561 150
type: UnificationXref
id: 237561
db: ncbitaxon

PTHR11937:SF387
type: RelationshipXref
id: PTHR11937:SF387
db: PANTHER Family
relationship type: By Homology

PTHR24055:SF162
type: RelationshipXref
id: PTHR24055:SF162
db: PANTHER Family
relationship type: By Homology

uniprot B2RYB8 763
type: UnificationXref
id: B2RYB8
db: uniprot

uniprot P23229 1061
type: UnificationXref
id: P23229
db: uniprot

STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r106
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r106 1606
participant stoichiometry: PARTICIPANT STOICHIOMETRY r106 1607
left: MEK
interaction type: STATE_TRANSITION
right: MEK

Laminin subunit beta-3
type: ProteinReference
xref: PTHR10574:SF268
xref: uniprot Q61087 1237
organism: Mus musculus

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: uniprot Q61084 154
organism: Mus musculus

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot Q61083 153
organism: Mus musculus

uniprot E1C891 1163
type: UnificationXref
id: E1C891
db: uniprot

Laminin
type: ProteinReference
xref: P00947
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Integrin signalling pathway.PROTEIN.GENERIC.Laminin
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Laminin-like protein epi-1
member entity reference: Laminin subunit beta 1
member entity reference: Laminin-like protein lam-2
member entity reference: Laminin subunit alpha-4
member entity reference: Multiple epidermal growth factor-like domains protein 9
member entity reference: Laminin subunit alpha 1
member entity reference: Laminin subunit beta-2
member entity reference: Laminin subunit beta 3
member entity reference: AGAP007629-PA
member entity reference: LAMC1 isoform 1
member entity reference: AGAP001381-PA
member entity reference: Uncharacterized protein
member entity reference: Laminin subunit beta-1
member entity reference: LAMinin related. See also lmb
member entity reference: NTN4 protein
member entity reference: Laminin subunit alpha
member entity reference: Laminin subunit beta-3
member entity reference: Laminin subunit gamma 3
member entity reference: Laminin subunit beta 4
member entity reference: Netrin 4
member entity reference: Laminin subunit gamma 2
member entity reference: EGF-like-domain, multiple 5 (Predicted)
member entity reference: Laminin subunit alpha-1
member entity reference: Laminin subunit gamma-2
member entity reference: Laminin subunit gamma-1
member entity reference: Laminin subunit alpha 2
member entity reference: Laminin subunit beta 2
member entity reference: Laminin subunit alpha 5
member entity reference: Laminin subunit gamma 1
member entity reference: LAMB3 isoform 1
member entity reference: Netrin-4
member entity reference: LAMA2 isoform 1
member entity reference: Laminin subunit alpha-2
member entity reference: Laminin subunit gamma-3
member entity reference: Wing blister, isoform B
member entity reference: AGAP007849-PA (Fragment)
member entity reference: Laminin subunit alpha-5
member entity reference: LAMA3 isoform 1
member entity reference: Laminin subunit alpha 4
member entity reference: Laminin subunit beta-4
member entity reference: Laminin subunit alpha-3

uniprot A8IL29 585
type: UnificationXref
id: A8IL29
db: uniprot

PTHR24055:SF158
type: RelationshipXref
id: PTHR24055:SF158
db: PANTHER Family
relationship type: By Homology

HETERODIMER ASSOCIATION LEFT Complex ILK PINCH Parvin - FAK- Complex Integrin alpha Paxillin Integrin beta Talin Vinculin Actin Integrin alpha alpha actinin Actin Integrin beta Filamin Collagen Laminin Fibronectin -RIGHT Complex Integrin beta Integrin alpha Paxillin FAK Talin Vinculin Actin Integrin alpha alpha actinin Actin Integrin beta Filamin Collagen Laminin Fibronectin - r77
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 1539
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 1537
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 1536
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 1538
left: Complex (ILK/PINCH/ Parvin)
left: Complex (Integrin _alpha/Paxillin/ Integrin beta/Talin/ Vinculin/Actin/ Integrin _alpha/alpha actinin/ Actin/Integrin beta/ Filamin/Collagen/ Laminin/Fibronectin)
left: FAK
display name: HETERODIMER_ASSOCIATION_LEFT__Complex__ILK_PINCH__Parvin_-_FAK-_Complex__Integrin__alpha_Paxillin__Integrin_beta_Talin__Vinculin_Actin__Integrin__alpha_alpha_actinin__Actin_Integrin_beta__Filamin_Collagen__Laminin_Fibronectin_-RIGHT__Complex__Integrin_beta_Integrin__alpha__Paxillin_FAK__Talin_Vinculin__Actin_Integrin__alpha__alpha_actinin_Actin__Integrin_beta_Filamin__Collagen_Laminin__Fibronectin_-_r77
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Integrin beta/Integrin _alpha/ Paxillin/FAK/ Talin/Vinculin/ Actin/Integrin _alpha/ alpha actinin/Actin/ Integrin beta/Filamin/ Collagen/Laminin/ Fibronectin)

uniprot Q7QEJ7 947
type: UnificationXref
id: Q7QEJ7
db: uniprot

uniprot A0A2I3S6R6 332
type: UnificationXref
id: A0A2I3S6R6
db: uniprot

uniprot P11835 791
type: UnificationXref
id: P11835
db: uniprot

PTHR11202:SF12
type: RelationshipXref
id: PTHR11202:SF12
db: PANTHER Family
relationship type: By Homology

Rac
type: Protein
entity reference: Rac
feature: ACTIVE 89
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F6PNT9 771
type: UnificationXref
id: F6PNT9
db: uniprot

uniprot F1P9X8 170
type: UnificationXref
id: F1P9X8
db: uniprot

PTHR11711:SF41
type: RelationshipXref
id: PTHR11711:SF41
db: PANTHER Family
relationship type: By Homology

uniprot B5DEG1 420
type: UnificationXref
id: B5DEG1
db: uniprot

Collagen alpha-5(IV) chain
type: ProteinReference
xref: PTHR24023:SF877
xref: uniprot Q28247 556
organism: Canis lupus familiaris

Integrin beta
type: ProteinReference
xref: uniprot Q92071 813
xref: PTHR10082:SF25
organism: Gallus gallus

Laminin subunit alpha-5
type: ProteinReference
xref: PTHR10574:SF261
xref: uniprot O15230 1215
organism: Homo sapiens

Protein tyrosine kinase 2
type: ProteinReference
xref: uniprot F7CW18 825
xref: PTHR24418:SF78
organism: Xenopus tropicalis

Abl s82 sa94 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Abl
stoichiometric coefficient: 1.0

uniprot Q5E9B5 1151
type: UnificationXref
id: Q5E9B5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rap1-RIGHT__Rap1-_r104
controller: Complex (Crk/C3G/ p130CAS)

FAK s17 sa17 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.851793120491741

uniprot A5D7R9 285
type: UnificationXref
id: A5D7R9
db: uniprot

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 287

uniprot F7EQ13 465
type: UnificationXref
id: F7EQ13
db: uniprot

uniprot Q61738 1077
type: UnificationXref
id: Q61738
db: uniprot

Integrin beta
type: Protein
entity reference: Integrin beta
feature: ACTIVE 89
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa56 1392
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

GRB2-related adapter protein
type: ProteinReference
xref: PTHR46037:SF2
xref: uniprot A6QLK6 189
organism: Bos taurus

AGAP007849-PA (Fragment)
type: ProteinReference
xref: PTHR10574:SF398
xref: uniprot Q5TQ35 1234
organism: Anopheles gambiae

uniprot F6WR53 984
type: UnificationXref
id: F6WR53
db: uniprot

PTHR11711:SF30
type: RelationshipXref
id: PTHR11711:SF30
db: PANTHER Family
relationship type: By Homology

uniprot F7HQD8 472
type: UnificationXref
id: F7HQD8
db: uniprot

PINCH
type: Protein
entity reference: PINCH
feature: COMPLEX PARTICIPANT BINDING FEATURE s61 sa88 1488
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Integrin beta-like protein 1
type: ProteinReference
xref: uniprot Q8VDV0 812
xref: PTHR10082:SF3
organism: Mus musculus

FAK s17 sa17 rs4
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.647709131634312
comment: MODIFICATION_RESIDUE_NAME=

Integrin subunit alpha 4
type: ProteinReference
xref: PTHR23220:SF78
xref: uniprot F1MEF6 1015
organism: Bos taurus

PTHR24055:SF172
type: RelationshipXref
id: PTHR24055:SF172
db: PANTHER Family
relationship type: By Homology

PTHR24055:SF171
type: RelationshipXref
id: PTHR24055:SF171
db: PANTHER Family
relationship type: By Homology

uniprot Q8CFN2 971
type: UnificationXref
id: Q8CFN2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24023:SF871
xref: uniprot F6TX60 448
organism: Macaca mulatta

PTHR24418:SF419
type: RelationshipXref
id: PTHR24418:SF419
db: PANTHER Family
relationship type: By Homology

uniprot Q99J82 860
type: UnificationXref
id: Q99J82
db: uniprot

STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r110
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r110 1584
participant stoichiometry: PARTICIPANT STOICHIOMETRY r110 1585
left: MEK
interaction type: STATE_TRANSITION
right: MEK

Laminin subunit gamma-2
type: ProteinReference
xref: PTHR10574:SF313
xref: uniprot Q61092 1238
organism: Mus musculus

Ras-related protein Rap-2c
type: ProteinReference
xref: PTHR24070:SF200
xref: uniprot Q9Y3L5 88
organism: Homo sapiens

uniprot P02453 499
type: UnificationXref
id: P02453
db: uniprot

uniprot B7QCW2 589
type: UnificationXref
id: B7QCW2
db: uniprot

uniprot H2R6I3 1270
type: UnificationXref
id: H2R6I3
db: uniprot

RAP2C, member of RAS oncogene family
type: ProteinReference
xref: PTHR24070:SF200
xref: uniprot F7A1D4 41
organism: Ornithorhynchus anatinus

uniprot Q6PC71 1300
type: UnificationXref
id: Q6PC71
db: uniprot

uniprot Q8N6T3 185
type: UnificationXref
id: Q8N6T3
db: uniprot

uniprot A0A1D5PXS9 255
type: UnificationXref
id: A0A1D5PXS9
db: uniprot

uniprot J9NYK4 490
type: UnificationXref
id: J9NYK4
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: PTHR12644:SF1
xref: uniprot G2HG81 219
organism: Pan troglodytes

uniprot O88990 728
type: UnificationXref
id: O88990
db: uniprot

COL12A1 isoform 1
type: ProteinReference
xref: uniprot H2QTA4 482
xref: PTHR24020:SF17
organism: Pan troglodytes

Actinin alpha 2
type: ProteinReference
xref: uniprot E2QUQ0 714
xref: PTHR11915:SF429
organism: Canis lupus familiaris

uniprot F6S9S9 654
type: UnificationXref
id: F6S9S9
db: uniprot

PTHR11937:SF359
type: RelationshipXref
id: PTHR11937:SF359
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__p130CAS-_Dock180-_ELMO-_Crk-RIGHT__Complex__p130CAS_Crk__Dock180_ELMO_-_r78
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 1527
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 1526
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 1528
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 1529
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 1530
left: Dock180
left: ELMO
left: Crk
left: p130CAS
interaction type: HETERODIMER_ASSOCIATION
right: Complex (p130CAS/Crk/ Dock180/ELMO)

RAP2C, member of RAS oncogene family
type: ProteinReference
xref: PTHR24070:SF200
xref: uniprot F1R684 31
organism: Danio rerio

Rho family GTPase 3
type: ProteinReference
xref: PTHR24072:SF24
xref: uniprot J9P4S7 1271
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: PTHR11915:SF434
xref: uniprot A0A1D5QZP3 706
organism: Macaca mulatta

Arp2/3 complex 34 kDa subunit
type: ProteinReference
xref: uniprot F1P1K3 208
xref: PTHR12058:SF0
organism: Gallus gallus

uniprot A0A1D5QKD3 93
type: UnificationXref
id: A0A1D5QKD3
db: uniprot

PTHR11937:SF362
type: RelationshipXref
id: PTHR11937:SF362
db: PANTHER Family
relationship type: By Homology

Integrin beta
type: Protein
entity reference: Integrin beta
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa13 1378
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
type: ProteinReference
xref: uniprot F7BZL6 898
xref: PTHR10155:SF3
organism: Macaca mulatta

uniprot Q07890 384
type: UnificationXref
id: Q07890
db: uniprot

Alpha-actinin-4
type: ProteinReference
xref: uniprot F7HU82 725
xref: PTHR11915:SF425
organism: Macaca mulatta

uniprot Q02384 382
type: UnificationXref
id: Q02384
db: uniprot

uniprot P07942 1218
type: UnificationXref
id: P07942
db: uniprot

uniprot G3V982 340
type: UnificationXref
id: G3V982
db: uniprot

alpha actinin
type: Protein
entity reference: alpha actinin
feature: COMPLEX PARTICIPANT BINDING FEATURE s43 sa43 1498
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PIP2 s58 sa67 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

uniprot Q02750 145
type: UnificationXref
id: Q02750
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot F7BZM9 216
organism: Monodelphis domestica

Vinculin
type: Protein
entity reference: Vinculin
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa31 1424
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PIK3CG isoform 1
type: ProteinReference
xref: uniprot A0A2J8QY32 870
xref: PTHR10048:SF34
organism: Pan troglodytes

uniprot B8JIV0 15
type: UnificationXref
id: B8JIV0
db: uniprot

uniprot P12080 1055
type: UnificationXref
id: P12080
db: uniprot