uniprot Q63844 152
type: UnificationXref
id: Q63844
db: uniprot

Jak1
type: ProteinReference
xref: P00953
standard name: Janus kinase 1
comment: ENTITY_REFERENCE_NOTES=Long Name: Janus kinase 1 Synonym: Jak1 Accession: P00953
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interferon-gamma signaling pathway.PROTEIN.GENERIC.Jak1
member entity reference: Tyrosine-protein kinase JAK1
member entity reference: Tyrosine-protein kinase

uniprot P63310 42
type: UnificationXref
id: P63310
db: uniprot

uniprot E2RGD0 199
type: UnificationXref
id: E2RGD0
db: uniprot

Suppressor of cytokine signaling 6
type: ProteinReference
xref: uniprot O14544 218
xref: PTHR10155:SF17
organism: Homo sapiens

uniprot P63086 123
type: UnificationXref
id: P63086
db: uniprot

Suppressor of variegation 2-10, isoform I
type: ProteinReference
xref: uniprot A1Z7P5 245
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r48 338
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Suppressor of cytokine signaling 3
type: ProteinReference
xref: PTHR10155:SF11
xref: uniprot O14543 217
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r48 339
type: Stoichiometry
physical entity: Jak2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r48 337
type: Stoichiometry
physical entity: Jak1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r48 336
type: Stoichiometry
physical entity: Complex (IFNGR1/IFNGR2/ Interferongamma)
stoichiometric coefficient: 1.0

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 3

uniprot Q39023 137
type: UnificationXref
id: Q39023
db: uniprot

uniprot A0A2I3S1N2 238
type: UnificationXref
id: A0A2I3S1N2
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P79996 125
organism: Gallus gallus

ncbitaxon 9544 18
type: UnificationXref
id: 9544
db: ncbitaxon

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q38AI6 133
organism: Trypanosoma brucei

uniprot Q62120 21
type: UnificationXref
id: Q62120
db: uniprot

uniprot G3V9W2 31
type: UnificationXref
id: G3V9W2
db: uniprot

ncbitaxon 9598 5
type: UnificationXref
id: 9598
db: ncbitaxon

IFNGR2
type: Protein
entity reference: IFNGR2
feature: IFNGR2 s7 sa5 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa5 322
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mus musculus
type: BioSource
xref: ncbitaxon 10090 22

PARTICIPANT STOICHIOMETRY r48 341
type: Stoichiometry
physical entity: Complex (IFNGR1/IFNGR2/ Interferongamma/Jak1/ Jak2)
stoichiometric coefficient: 1.0

uniprot A8WRD7 58
type: UnificationXref
id: A8WRD7
db: uniprot

uniprot Q80Y86 160
type: UnificationXref
id: Q80Y86
db: uniprot

PARTICIPANT STOICHIOMETRY r48 340
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7C798 85
xref: PTHR24055:SF109
organism: Macaca mulatta

uniprot F7DN97 255
type: UnificationXref
id: F7DN97
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P28482 112
organism: Homo sapiens

ncbitaxon 9258 84
type: UnificationXref
id: 9258
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F1PXS7 70
xref: PTHR24055:SF393
organism: Canis lupus familiaris

Suppressor of cytokine signaling 4
type: ProteinReference
xref: uniprot E2RGD0 199
xref: PTHR10155:SF21
organism: Canis lupus familiaris

ncbitaxon 36329 156
type: UnificationXref
id: 36329
db: ncbitaxon

ncbitaxon 7227 103
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot F6Y4G8 79
type: UnificationXref
id: F6Y4G8
db: uniprot

Cytokine-inducible SH2-containing protein
type: ProteinReference
xref: PTHR10155:SF9
xref: uniprot Q9PW70 237
organism: Gallus gallus

uniprot Q5A1D3 146
type: UnificationXref
id: Q5A1D3
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P27361 109
organism: Homo sapiens

uniprot F5HEA9 71
type: UnificationXref
id: F5HEA9
db: uniprot

Complex (IFNGR1/IFNGR2/ Interferongamma)
type: Complex
component stoichiometry: IFNGR1 s1 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: Interferongamma s3 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: IFNGR2 s2 sa2 STOICHIOMETRY ID COMPLEX
component: IFNGR2
component: IFNGR1
component: Interferongamma
feature: COMPLEX BINDING FEATURE s75 a112 317
feature: COMPLEX BINDING FEATURE s75 a112 315
feature: COMPLEX BINDING FEATURE s75 a112 313
cellular location: cytosol

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 189

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

DISSOCIATION_LEFT__Complex__IFNGR1_IFNGR2__Interferongamma_STAT1__Jak1_Jak2_-RIGHT__STAT1-_Complex__IFNGR1_IFNGR2__Interferongamma_Jak1__Jak2_-_r47
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 342
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 344
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 343
left: Complex (IFNGR1/IFNGR2/ Interferongamma/STAT1/ Jak1/Jak2)
interaction type: DISSOCIATION
right: Complex (IFNGR1/IFNGR2/ Interferongamma/Jak1/ Jak2)
right: STAT1

PARTICIPANT STOICHIOMETRY r45 348
type: Stoichiometry
physical entity: Complex (IFNGR1/IFNGR2/ Interferongamma)
stoichiometric coefficient: 1.0

Suppressor of cytokine signaling at 36E, isoform D
type: ProteinReference
xref: uniprot Q8INY1 229
xref: PTHR10155:SF0
organism: Drosophila melanogaster

IFNGR1 s5 sa4 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.464466147903891

PARTICIPANT STOICHIOMETRY r45 345
type: Stoichiometry
physical entity: IFNGR2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 346
type: Stoichiometry
physical entity: IFNGR1
stoichiometric coefficient: 1.0

uniprot P14681 105
type: UnificationXref
id: P14681
db: uniprot

PARTICIPANT STOICHIOMETRY r45 347
type: Stoichiometry
physical entity: Interferongamma
stoichiometric coefficient: 1.0

uniprot A8X1S0 60
type: UnificationXref
id: A8X1S0
db: uniprot

Interferon gamma
type: ProteinReference
xref: PTHR11419:SF0
xref: uniprot P49708 41
organism: Gallus gallus

ncbitaxon 10090 22
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot O14512 216
type: UnificationXref
id: O14512
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot O42376 101
organism: Danio rerio

SOCS3 isoform 1
type: ProteinReference
xref: uniprot H2QDZ6 210
xref: PTHR10155:SF11
organism: Pan troglodytes

uniprot K7B8T0 262
type: UnificationXref
id: K7B8T0
db: uniprot

uniprot F7CWQ1 284
type: UnificationXref
id: F7CWQ1
db: uniprot

uniprot A4FV15 246
type: UnificationXref
id: A4FV15
db: uniprot

Jak2 s11 sa9 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.82
comment: MODIFICATION_RESIDUE_NAME=

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: PTHR46559:SF1
xref: uniprot H2RIH8 287
organism: Pan troglodytes

Suppressor of cytokine signaling 4
type: ProteinReference
xref: PTHR10155:SF21
xref: uniprot F6YVE7 203
organism: Macaca mulatta

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 5

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Jak1-RIGHT__Pi-_Jak1-_r35
controller: PTP

IFNGR2 s7 sa5 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.9136582736930956

Mitogen-activated protein kinase 11
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot Q15759 130
organism: Homo sapiens

uniprot Q8MXI4 162
type: UnificationXref
id: Q8MXI4
db: uniprot

uniprot I0FMS6 288
type: UnificationXref
id: I0FMS6
db: uniprot

STAT1 s58 a90 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT1
stoichiometric coefficient: 2.0

Suppressor of cytokine signaling 7
type: ProteinReference
xref: PTHR10155:SF5
xref: uniprot O14512 216
organism: Homo sapiens

uniprot F6ZTS0 82
type: UnificationXref
id: F6ZTS0
db: uniprot

ncbitaxon 237631 44
type: UnificationXref
id: 237631
db: ncbitaxon

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q7KQK7 155
organism: Plasmodium falciparum

PARTICIPANT STOICHIOMETRY r51 335
type: Stoichiometry
physical entity: Complex (IFNGR1/IFNGR2/ Interferongamma/STAT1/ Jak1/Jak2)
stoichiometric coefficient: 1.0

uniprot A0A1D5QUZ8 48
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

PARTICIPANT STOICHIOMETRY r51 334
type: Stoichiometry
physical entity: 2 ADP
stoichiometric coefficient: 1.0

uniprot O14508 215
type: UnificationXref
id: O14508
db: uniprot

uniprot P81718 294
type: UnificationXref
id: P81718
db: uniprot

PARTICIPANT STOICHIOMETRY r51 331
type: Stoichiometry
physical entity: STAT1
stoichiometric coefficient: 1.0

PTP
type: ProteinReference
xref: P00960
standard name: protein tyrosine phosphatase
comment: ENTITY_REFERENCE_NOTES=Long Name: protein tyrosine phosphatase Synonym: PTP Accession: P00960
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interferon-gamma signaling pathway.PROTEIN.GENERIC.PTP
member entity reference: Tyrosine-protein phosphatase non-receptor type 11
member entity reference: Tyrosine-protein phosphatase non-receptor type
member entity reference: Tyrosine-protein phosphatase non-receptor type 6
member entity reference: Tyrosine-protein phosphatase corkscrew
member entity reference: Tyrosine-protein phosphatase non-receptor type ptp-2

PARTICIPANT STOICHIOMETRY r51 333
type: Stoichiometry
physical entity: Complex (IFNGR1/IFNGR2/ Interferongamma/Jak1/ Jak2)
stoichiometric coefficient: 1.0

uniprot E2RJ88 250
type: UnificationXref
id: E2RJ88
db: uniprot

PARTICIPANT STOICHIOMETRY r51 332
type: Stoichiometry
physical entity: 2 ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r41 351
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

uniprot A0A0R4IKK9 45
type: UnificationXref
id: A0A0R4IKK9
db: uniprot

uniprot Q9LMM5 176
type: UnificationXref
id: Q9LMM5
db: uniprot

uniprot F1PIY7 29
type: UnificationXref
id: F1PIY7
db: uniprot

Suppressor of cytokine signaling 2
type: ProteinReference
xref: PTHR10155:SF7
xref: uniprot O14508 215
organism: Homo sapiens

uniprot Q9JLY0 235
type: UnificationXref
id: Q9JLY0
db: uniprot

uniprot F1QWX8 12
type: UnificationXref
id: F1QWX8
db: uniprot

S727 STAT1 s58 a90 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S727
feature location: S727 STAT1 s58 a90 rs2 S727
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S727
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.9089356867941967

PARTICIPANT STOICHIOMETRY r41 350
type: Stoichiometry
physical entity: STAT1
stoichiometric coefficient: 1.0

uniprot Q8VHQ2 230
type: UnificationXref
id: Q8VHQ2
db: uniprot

S727 STAT1 s9 sa7 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S727
feature location: S727 STAT1 s9 sa7 rs2 S727
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S727
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.9089356867941967

uniprot O75925 265
type: UnificationXref
id: O75925
db: uniprot

uniprot Q4Q0B0 142
type: UnificationXref
id: Q4Q0B0
db: uniprot

Stress-activated protein kinase jnk-1
type: ProteinReference
xref: uniprot Q8WQG9 165
xref: PTHR24055:SF341
organism: Caenorhabditis elegans

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot A0A3Q2TY19 53
organism: Gallus gallus

Mitogen-activated protein kinase 4
type: ProteinReference
xref: uniprot Q5Z859 149
organism: Oryza sativa

Suppressor of cytokine signaling 4
type: ProteinReference
xref: PTHR10155:SF21
xref: uniprot B5DF08 195
organism: Rattus norvegicus

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot O15264 98
xref: PTHR24055:SF107
organism: Homo sapiens

uniprot K7BMJ0 214
type: UnificationXref
id: K7BMJ0
db: uniprot

PARTICIPANT STOICHIOMETRY r41 349
type: Stoichiometry
physical entity: STAT1
stoichiometric coefficient: 2.0

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Complex__IFNGR1_IFNGR2__Interferongamma_-_Jak1-_ATP-_Jak2-RIGHT__ADP-_Complex__IFNGR1_IFNGR2__Interferongamma_Jak1__Jak2_-_r48
controller: Jak1

uniprot F7B5L8 83
type: UnificationXref
id: F7B5L8
db: uniprot

Interferon-gamma signaling pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Jak2-_ATP-RIGHT__ADP-_Jak2-_r33
pathway component: DISSOCIATION_LEFT__Complex__IFNGR1_IFNGR2__Interferongamma_STAT1__Jak1_Jak2_-RIGHT__STAT1-_Complex__IFNGR1_IFNGR2__Interferongamma_Jak1__Jak2_-_r47
pathway component: STATE_TRANSITION_LEFT__Jak1-RIGHT__Pi-_Jak1-_r35
pathway component: DISSOCIATION_LEFT__STAT1-RIGHT__STAT1-_Pi-_r41
pathway component: STATE_TRANSITION_LEFT__Jak1-_ATP-RIGHT__Jak1-_ADP-_r32
pathway component: HETERODIMER_ASSOCIATION_LEFT__IFNGR2-_IFNGR1-_Interferongamma-RIGHT__Complex__IFNGR1_IFNGR2__Interferongamma_-_r45
pathway component: TRANSPORT_LEFT__STAT1-RIGHT__STAT1-_r29
pathway component: HETERODIMER_ASSOCIATION_LEFT__STAT1-_2_ATP-_Complex__IFNGR1_IFNGR2__Interferongamma_Jak1__Jak2_-RIGHT__2_ADP-_Complex__IFNGR1_IFNGR2__Interferongamma_STAT1__Jak1_Jak2_-_r51
pathway component: PHYSICAL_STIMULATION
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__IFNGR1_IFNGR2__Interferongamma_-_Jak1-_ATP-_Jak2-RIGHT__ADP-_Complex__IFNGR1_IFNGR2__Interferongamma_Jak1__Jak2_-_r48
pathway component: STATE_TRANSITION_LEFT__Jak2-RIGHT__Jak2-_Pi-_r36
xref: PANTHER Pathway P00035 1
comment: MODEL_NOTES=Panther Pathway: P00035 The interferon-gamma signaling pathway modulates the antiproliferative and antiviral properties of interferon-gamma. Signal transduction from the membrane to the nucleus is rapid and direct. The main signaling pathway involves the activation of STAT1 by the Jak family of tyrosine kinases at the cell membrane, followed by release, dimerization, and translocation of STAT1 to the nucleus, where they transcriptional induce expression of many gene products. Medline=11929133 Medline=14525967 PMID: 11929133 PMID: 14525967

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q95NE7 167
xref: PTHR24055:SF110
organism: Pan troglodytes

IFNGR1 s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IFNGR1
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q63844 152
xref: PTHR24055:SF393
organism: Mus musculus

Suppressor of cytokine signaling 6
type: ProteinReference
xref: uniprot Q9JLY0 235
xref: PTHR10155:SF17
organism: Mus musculus

uniprot Q7PVR1 157
type: UnificationXref
id: Q7PVR1
db: uniprot

CISH isoform 2
type: ProteinReference
xref: PTHR10155:SF9
xref: uniprot A0A2I3T047 191
organism: Pan troglodytes

uniprot Q9WTU6 183
type: UnificationXref
id: Q9WTU6
db: uniprot

uniprot P53778 120
type: UnificationXref
id: P53778
db: uniprot

SOCS5 isoform 1
type: ProteinReference
xref: PTHR10155:SF15
xref: uniprot H2RII6 212
organism: Pan troglodytes

uniprot Q38AI6 133
type: UnificationXref
id: Q38AI6
db: uniprot

Mitogen-activated protein kinase 11
type: ProteinReference
xref: uniprot Q9LMM5 176
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r47 344
type: Stoichiometry
physical entity: Complex (IFNGR1/IFNGR2/ Interferongamma/Jak1/ Jak2)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r47 342
type: Stoichiometry
physical entity: Complex (IFNGR1/IFNGR2/ Interferongamma/STAT1/ Jak1/Jak2)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r47 343
type: Stoichiometry
physical entity: STAT1
stoichiometric coefficient: 2.0

ncbitaxon 321614 72
type: UnificationXref
id: 321614
db: ncbitaxon

Mitogen-activated protein kinase FUS3
type: ProteinReference
xref: uniprot P16892 107
organism: Saccharomyces cerevisiae

E3 SUMO-protein ligase PIAS3
type: ProteinReference
xref: PTHR10782:SF10
xref: uniprot O70260 264
organism: Rattus norvegicus

uniprot Q9WTY9 184
type: UnificationXref
id: Q9WTY9
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7B5L8 83
xref: PTHR24055:SF172
organism: Ornithorhynchus anatinus

uniprot Q9Z2A6 187
type: UnificationXref
id: Q9Z2A6
db: uniprot

uniprot A0A2I3T047 191
type: UnificationXref
id: A0A2I3T047
db: uniprot

IFNGR1 s12 sa10 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.464466147903891

PARTICIPANT STOICHIOMETRY r33 358
type: Stoichiometry
physical entity: Jak2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r33 359
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot Q39026 139
type: UnificationXref
id: Q39026
db: uniprot

Mitogen-activated protein kinase 4
type: ProteinReference
xref: uniprot Q39024 138
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot Q39027 140
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot Q39026 139
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot Q39021 135
organism: Arabidopsis thaliana

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q4Q0B0 142
organism: Leishmania major

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q39023 137
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 2
type: ProteinReference
xref: uniprot Q39022 136
organism: Arabidopsis thaliana

PIAS1 isoform 4
type: ProteinReference
xref: uniprot A0A2I3SSB8 242
xref: PTHR10782:SF11
organism: Pan troglodytes

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 18

00696
type: UnificationXref
id: MOD:00696
db: mod

Jak2 s6 a7 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.82
comment: MODIFICATION_RESIDUE_NAME=

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2RA86 95
xref: PTHR24055:SF393
organism: Pan troglodytes

E3 SUMO-protein ligase PIAS2
type: ProteinReference
xref: PTHR10782:SF12
xref: uniprot Q8C5D8 269
organism: Mus musculus

Mitogen-activated protein kinase 15
type: ProteinReference
xref: uniprot Q80Y86 160
xref: PTHR24055:SF79
organism: Mus musculus

Jak2 s11 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Jak2
stoichiometric coefficient: 1.0

Tyrosine-protein phosphatase non-receptor type ptp-2
type: ProteinReference
xref: uniprot G5EC24 285
xref: PTHR46257:SF3
organism: Caenorhabditis elegans

uniprot Q62689 23
type: UnificationXref
id: Q62689
db: uniprot

uniprot F1PQ60 252
type: UnificationXref
id: F1PQ60
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A1D5R9X3 296
xref: PTHR11801:SF18
organism: Macaca mulatta

2 ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Complex__IFNGR1_IFNGR2__Interferongamma_-_Jak1-_ATP-_Jak2-RIGHT__ADP-_Complex__IFNGR1_IFNGR2__Interferongamma_Jak1__Jak2_-_r48
controller: Jak2

uniprot A0A2I3SSB8 242
type: UnificationXref
id: A0A2I3SSB8
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot Q9DGD9 170
organism: Danio rerio

IFNGR1 s12 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IFNGR1
stoichiometric coefficient: 1.0

uniprot H2R6X1 274
type: UnificationXref
id: H2R6X1
db: uniprot

uniprot P29349 289
type: UnificationXref
id: P29349
db: uniprot

DISSOCIATION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY r32 364
type: Stoichiometry
physical entity: Jak1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r32 365
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot A0A1D5PXC6 46
type: UnificationXref
id: A0A1D5PXC6
db: uniprot

PARTICIPANT STOICHIOMETRY r32 362
type: Stoichiometry
physical entity: Jak1
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 14B
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q9DGE1 171
organism: Danio rerio

STAT1
type: Complex
component stoichiometry: STAT1 s59 a91 STOICHIOMETRY ID COMPLEX
component: STAT1
feature: ACTIVE 25
cellular location: nucleus

PARTICIPANT STOICHIOMETRY r32 363
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 14A
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q9DGE2 172
organism: Danio rerio

STAT1
type: Complex
component stoichiometry: STAT1 s58 a90 STOICHIOMETRY ID COMPLEX
component: STAT1
feature: ACTIVE 25
cellular location: cytosol

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot F6YAB9 80
organism: Monodelphis domestica

uniprot A0A0D1C4Y4 43
type: UnificationXref
id: A0A0D1C4Y4
db: uniprot

ncbitaxon 8364 75
type: UnificationXref
id: 8364
db: ncbitaxon

Suppressor of cytokine signaling 3
type: ProteinReference
xref: PTHR10155:SF11
xref: uniprot O35718 220
organism: Mus musculus

uniprot Q16539 131
type: UnificationXref
id: Q16539
db: uniprot

Suppressor of cytokine signaling 2
type: ProteinReference
xref: uniprot O35717 219
xref: PTHR10155:SF7
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r33 361
type: Stoichiometry
physical entity: Jak2
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QS62 93
xref: PTHR24055:SF172
organism: Pan troglodytes

IFNGR2
type: Protein
entity reference: IFNGR2
feature: IFNGR2 s24 a44 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r33 360
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

STAT1
type: ProteinReference
xref: P00961
standard name: Signal transducers and activaotrs of transcription 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Signal transducers and activaotrs of transcription 1 Synonym: STAT1 Accession: P00961
comment: ENTITY_REFERENCE_ID_DESC=Interferon-gamma signaling pathway.PROTEIN.GENERIC.STAT1
member entity reference: Signal transducer and activator of transcription 1
member entity reference: Signal transducer and activator of transcription
member entity reference: Signal transducer and activator of transcription 1-alpha/beta

uniprot F7FHD1 90
type: UnificationXref
id: F7FHD1
db: uniprot

uniprot P79996 125
type: UnificationXref
id: P79996
db: uniprot

uniprot Q54QB1 144
type: UnificationXref
id: Q54QB1
db: uniprot

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__STAT1-RIGHT__STAT1-_Pi-_r41
controller: PTP

uniprot F7DX37 256
type: UnificationXref
id: F7DX37
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A4FV00 54
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot F7CYE3 86
organism: Xenopus tropicalis

uniprot Q9DGE2 172
type: UnificationXref
id: Q9DGE2
db: uniprot

Protein inhibitor of activated STAT 2
type: ProteinReference
xref: PTHR10782:SF12
xref: uniprot F7DX37 256
organism: Ornithorhynchus anatinus

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot A7EJF2 55
type: UnificationXref
id: A7EJF2
db: uniprot

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 174

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

PTHR20859:SF46
type: RelationshipXref
id: PTHR20859:SF46
db: PANTHER Family
relationship type: By Homology

Signal transducer and activator of transcription 1-alpha/beta
type: ProteinReference
xref: uniprot P42224 298
xref: PTHR11801:SF18
organism: Homo sapiens

PIAS
type: ProteinReference
xref: P00958
standard name: Protein inhibitors of activated STATs
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interferon-gamma signaling pathway.PROTEIN.GENERIC.PIAS
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein inhibitors of activated STATs Synonym: PIAS Accession: P00958
member entity reference: PIAS1 isoform 4
member entity reference: Uncharacterized protein
member entity reference: Protein inhibitor of activated STAT 1
member entity reference: PIAS2 isoform 1
member entity reference: E3 SUMO-protein ligase PIAS4
member entity reference: E3 SUMO-protein ligase PIAS1
member entity reference: E3 SUMO-protein ligase PIAS3
member entity reference: Suppressor of variegation 2-10, isoform I
member entity reference: E3 SUMO-protein ligase PIAS2
member entity reference: Protein inhibitor of activated STAT 2
member entity reference: Protein inhibitor of activated STAT 3
member entity reference: Pias4 protein
member entity reference: PIAS4 protein
member entity reference: E3 SUMO-protein ligase gei-17
member entity reference: PIAS3 protein
member entity reference: Protein inhibitor of activated STAT 1 (Predicted)
member entity reference: PIAS3 isoform 4
member entity reference: Protein inhibitor of-activated STAT 1

PTHR10155:SF5
type: RelationshipXref
id: PTHR10155:SF5
db: PANTHER Family
relationship type: By Homology

uniprot H2R7K2 286
type: UnificationXref
id: H2R7K2
db: uniprot

PTHR10155:SF7
type: RelationshipXref
id: PTHR10155:SF7
db: PANTHER Family
relationship type: By Homology

eco ECO:0000304 14
type: UnificationXref
id: ECO:0000304
db: eco

PTHR10155:SF9
type: RelationshipXref
id: PTHR10155:SF9
db: PANTHER Family
relationship type: By Homology

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Jak2-_ATP-RIGHT__ADP-_Jak2-_r33
control type: INHIBITION
controller: SOCS

Uncharacterized protein
type: ProteinReference
xref: PTHR10782:SF12
xref: uniprot A0A3Q1LPE8 243
organism: Bos taurus

PTHR10155:SF0
type: RelationshipXref
id: PTHR10155:SF0
db: PANTHER Family
relationship type: By Homology

Complex (IFNGR1/IFNGR2/ Interferongamma/STAT1/ Jak1/Jak2)
type: Complex
component stoichiometry: Interferongamma s8 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: Jak1 s10 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: IFNGR1 s5 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: STAT1 s9 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: IFNGR2 s7 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Jak2 s11 sa9 STOICHIOMETRY ID COMPLEX
component: Jak1
component: IFNGR1
component: Jak2
component: STAT1
component: IFNGR2
component: Interferongamma
feature: COMPLEX BINDING FEATURE s81 a119 325
feature: COMPLEX BINDING FEATURE s81 a119 327
feature: COMPLEX BINDING FEATURE s81 a119 319
feature: COMPLEX BINDING FEATURE s81 a119 321
feature: COMPLEX BINDING FEATURE s81 a119 329
feature: COMPLEX BINDING FEATURE s81 a119 323
cellular location: cytosol

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot F6ZTS0 82
organism: Macaca mulatta

E3 SUMO-protein ligase PIAS2
type: ProteinReference
xref: PTHR10782:SF12
xref: uniprot Q6AZ28 268
organism: Rattus norvegicus

Mitogen-activated protein kinase mpk-1
type: ProteinReference
xref: uniprot P39745 113
organism: Caenorhabditis elegans

uniprot F7BFK3 205
type: UnificationXref
id: F7BFK3
db: uniprot

uniprot Q84UI5 161
type: UnificationXref
id: Q84UI5
db: uniprot

Y701 STAT1 s49 a73 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y701
feature location: Y701 STAT1 s49 a73 rs1 Y701
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4619459670373214
comment: MODIFICATION_RESIDUE_NAME=Y701

Jak1 s10 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Jak1
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF15
xref: uniprot F7AZP2 204
organism: Monodelphis domestica

ncbitaxon 9031 28
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot P42224 298
type: UnificationXref
id: P42224
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7D8G7 206
xref: PTHR10155:SF5
organism: Macaca mulatta

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 59

PTHR46559:SF3
type: RelationshipXref
id: PTHR46559:SF3
db: PANTHER Family
relationship type: By Homology

Protein inhibitor of activated STAT 3
type: ProteinReference
xref: PTHR10782:SF10
xref: uniprot E2R2U8 249
organism: Canis lupus familiaris

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 114

PIAS4 protein
type: ProteinReference
xref: PTHR10782:SF9
xref: uniprot A4FV15 246
organism: Bos taurus

PTHR46559:SF1
type: RelationshipXref
id: PTHR46559:SF1
db: PANTHER Family
relationship type: By Homology

Signal transducer and activator of transcription 1
type: ProteinReference
xref: PTHR11801:SF18
xref: uniprot P42225 299
organism: Mus musculus

uniprot O61443 102
type: UnificationXref
id: O61443
db: uniprot

uniprot O15264 98
type: UnificationXref
id: O15264
db: uniprot

uniprot F7GN93 91
type: UnificationXref
id: F7GN93
db: uniprot

uniprot Q6P6T3 277
type: UnificationXref
id: Q6P6T3
db: uniprot

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: uniprot I0FMS6 288
xref: PTHR46257:SF4
organism: Macaca mulatta

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot O08911 97
organism: Mus musculus

STAT1
type: Protein
entity reference: STAT1
feature: ACTIVE 25
feature: S727 STAT1 s58 a90 rs2
feature: Y701 STAT1 s58 a90 rs1

uniprot F6YLX1 30
type: UnificationXref
id: F6YLX1
db: uniprot

Serine kinase
type: ProteinReference
xref: P00955
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interferon-gamma signaling pathway.PROTEIN.GENERIC.Serine kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: Serine kinase Synonym: Synonym not specified Accession: P00955
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 10
member entity reference: Mitogen-activated protein kinase 19
member entity reference: Mitogen-activated protein kinase spk1
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Mitogen-activated protein kinase 4
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Mitogen-activated protein kinase 15
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Mitogen-activated protein kinase KSS1
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase (Fragment)
member entity reference: Mitogen-activated protein kinase 12
member entity reference: Mitogen-activated protein kinase pmk-1
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase 18
member entity reference: Mitogen-activated protein kinase mpk-1
member entity reference: Mitogen-activated protein kinase p38b
member entity reference: Mitogen-activated protein kinase 6
member entity reference: Mitogen-activated protein kinase 16
member entity reference: Extracellular signal-regulated kinase 1
member entity reference: Mitogen-activated protein kinase 2

Interferongamma s14 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Interferongamma
stoichiometric coefficient: 1.0

uniprot F6UUY8 202
type: UnificationXref
id: F6UUY8
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot D4A3U7 63
organism: Rattus norvegicus

Suppressor of cytokine-signaling 7
type: ProteinReference
xref: PTHR10155:SF5
xref: uniprot A0A0G2K9S1 190
organism: Rattus norvegicus

uniprot P49186 118
type: UnificationXref
id: P49186
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F7EI48 89
organism: Monodelphis domestica

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot E2R2N2 65
organism: Canis lupus familiaris

ncbitaxon 185431 134
type: UnificationXref
id: 185431
db: ncbitaxon

Mitogen-activated protein kinase p38b
type: ProteinReference
xref: uniprot O61443 102
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r36 354
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r36 353
type: Stoichiometry
physical entity: Jak2
stoichiometric coefficient: 1.0

Jak1 s4 a6 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.68

PTHR46257:SF1
type: RelationshipXref
id: PTHR46257:SF1
db: PANTHER Family
relationship type: By Homology

Interferongamma
type: ProteinReference
xref: P00954
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Interferongamma Synonym: Synonym not specified Accession: P00954
comment: ENTITY_REFERENCE_ID_DESC=Interferon-gamma signaling pathway.PROTEIN.GENERIC.Interferon_gamma_
member entity reference: Interferon gamma

PARTICIPANT STOICHIOMETRY r36 352
type: Stoichiometry
physical entity: Jak2
stoichiometric coefficient: 1.0

TRANSPORT
type: RelationshipTypeVocabulary

STATE_TRANSITION_LEFT__Jak1-RIGHT__Pi-_Jak1-_r35
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 355
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 357
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 356
left: Jak1
interaction type: STATE_TRANSITION
right: Jak1
right: Pi

PTHR24055:SF222
type: RelationshipXref
id: PTHR24055:SF222
db: PANTHER Family
relationship type: By Homology

PTHR46257:SF4
type: RelationshipXref
id: PTHR46257:SF4
db: PANTHER Family
relationship type: By Homology

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 56

PTHR46257:SF3
type: RelationshipXref
id: PTHR46257:SF3
db: PANTHER Family
relationship type: By Homology

uniprot E2R2N2 65
type: UnificationXref
id: E2R2N2
db: uniprot

uniprot F7EI48 89
type: UnificationXref
id: F7EI48
db: uniprot

uniprot O54928 221
type: UnificationXref
id: O54928
db: uniprot

PTHR11801:SF18
type: RelationshipXref
id: PTHR11801:SF18
db: PANTHER Family
relationship type: By Homology

uniprot P38484 240
type: UnificationXref
id: P38484
db: uniprot

E3 SUMO-protein ligase PIAS4
type: ProteinReference
xref: PTHR10782:SF9
xref: uniprot Q9JM05 272
organism: Mus musculus

uniprot Q15759 130
type: UnificationXref
id: Q15759
db: uniprot

uniprot E1BCP6 8
type: UnificationXref
id: E1BCP6
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot C8V7D1 61
organism: Emericella nidulans

uniprot P23458 34
type: UnificationXref
id: P23458
db: uniprot

uniprot P27638 110
type: UnificationXref
id: P27638
db: uniprot

uniprot P27361 109
type: UnificationXref
id: P27361
db: uniprot

uniprot Q9SJG9 182
type: UnificationXref
id: Q9SJG9
db: uniprot

Mitogen-activated protein kinase 16
type: ProteinReference
xref: uniprot Q8W4J2 164
organism: Arabidopsis thaliana

uniprot P01580 37
type: UnificationXref
id: P01580
db: uniprot

IFNGR2
type: Protein
entity reference: IFNGR2
feature: IFNGR2 s2 sa2 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 316
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Complex (IFNGR1/IFNGR2/ Interferongamma/Jak1/ Jak2)
type: Complex
component stoichiometry: Interferongamma s14 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: Jak2 s16 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: Jak1 s15 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: IFNGR1 s12 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: IFNGR2 s13 sa11 STOICHIOMETRY ID COMPLEX
component: Jak1
component: IFNGR1
component: Jak2
component: Interferongamma
component: IFNGR2
feature: COMPLEX BINDING FEATURE s94 a135 309
feature: COMPLEX BINDING FEATURE s94 a135 311
feature: COMPLEX BINDING FEATURE s94 a135 307
feature: COMPLEX BINDING FEATURE s94 a135 303
feature: COMPLEX BINDING FEATURE s94 a135 305
cellular location: cytosol

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot P45983 115
organism: Homo sapiens

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P45984 116
xref: PTHR24055:SF172
organism: Homo sapiens

uniprot F7EH19 88
type: UnificationXref
id: F7EH19
db: uniprot

uniprot F6ZKB3 81
type: UnificationXref
id: F6ZKB3
db: uniprot

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: uniprot F1N339 281
xref: PTHR46559:SF1
organism: Bos taurus

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q9Z1B7 186
organism: Mus musculus

Y701 STAT1 s59 a91 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y701
feature location: Y701 STAT1 s59 a91 rs1 Y701
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4619459670373214
comment: MODIFICATION_RESIDUE_NAME=Y701

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

uniprot O70260 264
type: UnificationXref
id: O70260
db: uniprot

uniprot Q61831 150
type: UnificationXref
id: Q61831
db: uniprot

uniprot F1PSF4 201
type: UnificationXref
id: F1PSF4
db: uniprot

uniprot O14543 217
type: UnificationXref
id: O14543
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 16

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot Q9M1Z5 180
organism: Arabidopsis thaliana

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF2
xref: uniprot F1QWX8 12
organism: Danio rerio

ncbitaxon 284812 111
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot H9ERN5 213
type: UnificationXref
id: H9ERN5
db: uniprot

uniprot P16892 107
type: UnificationXref
id: P16892
db: uniprot

uniprot P21708 108
type: UnificationXref
id: P21708
db: uniprot

uniprot Q95NE7 167
type: UnificationXref
id: Q95NE7
db: uniprot

uniprot H2Q6L9 209
type: UnificationXref
id: H2Q6L9
db: uniprot

uniprot H2RII6 212
type: UnificationXref
id: H2RII6
db: uniprot

ACTIVE 25
type: EntityFeature
comment: Active state

uniprot G5EC24 285
type: UnificationXref
id: G5EC24
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6ZKB3 81
organism: Macaca mulatta

uniprot Q9Z1B7 186
type: UnificationXref
id: Q9Z1B7
db: uniprot

uniprot Q63538 151
type: UnificationXref
id: Q63538
db: uniprot

ncbitaxon 5664 143
type: UnificationXref
id: 5664
db: ncbitaxon

uniprot P92208 126
type: UnificationXref
id: P92208
db: uniprot

uniprot F1N339 281
type: UnificationXref
id: F1N339
db: uniprot

Jak2 s65 a93 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.82
comment: MODIFICATION_RESIDUE_NAME=

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F6WV79 78
organism: Monodelphis domestica

uniprot Q17446 132
type: UnificationXref
id: Q17446
db: uniprot

PIAS3 protein
type: ProteinReference
xref: uniprot A6QQU9 247
xref: PTHR10782:SF10
organism: Bos taurus

Mitogen-activated protein kinase 19
type: ProteinReference
xref: uniprot Q9LUC3 178
organism: Arabidopsis thaliana

Mitogen-activated protein kinase spk1
type: ProteinReference
xref: uniprot P27638 110
organism: Schizosaccharomyces pombe

STAT1 s59 a91 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT1
stoichiometric coefficient: 2.0

ncbitaxon 7165 158
type: UnificationXref
id: 7165
db: ncbitaxon

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A8WRD7 58
organism: Caenorhabditis briggsae

uniprot Q9C5C0 168
type: UnificationXref
id: Q9C5C0
db: uniprot

STAT1 s9 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT1
stoichiometric coefficient: 1.0

uniprot Q861R0 228
type: UnificationXref
id: Q861R0
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot P47811 117
organism: Mus musculus

uniprot Q9Y6X2 273
type: UnificationXref
id: Q9Y6X2
db: uniprot

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: uniprot F7CWQ1 284
xref: PTHR46257:SF4
organism: Monodelphis domestica

IFNGR1
type: Protein
entity reference: IFNGR1
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa10 304
feature: IFNGR1 s12 sa10 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 100

uniprot Q2HJ53 226
type: UnificationXref
id: Q2HJ53
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P21708 108
xref: PTHR24055:SF393
organism: Rattus norvegicus

uniprot Q9LUC3 178
type: UnificationXref
id: Q9LUC3
db: uniprot

uniprot P15260 275
type: UnificationXref
id: P15260
db: uniprot

uniprot F6TXC2 76
type: UnificationXref
id: F6TXC2
db: uniprot

uniprot B5DF08 195
type: UnificationXref
id: B5DF08
db: uniprot

uniprot Q9LM33 175
type: UnificationXref
id: Q9LM33
db: uniprot

Cish protein
type: ProteinReference
xref: PTHR10155:SF9
xref: uniprot B1WBX9 192
organism: Rattus norvegicus

Danio rerio
type: BioSource
xref: ncbitaxon 7955 13

ncbitaxon 44689 145
type: UnificationXref
id: 44689
db: ncbitaxon

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot Q63538 151
xref: PTHR24055:SF146
organism: Rattus norvegicus

Jak2
type: Protein
entity reference: Jak2
feature: ACTIVE 25
feature: Jak2 s65 a93 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STAT1
type: Protein
entity reference: STAT1
feature: S727 STAT1 s59 a91 rs2
feature: ACTIVE 25
feature: Y701 STAT1 s59 a91 rs1

uniprot P53779 121
type: UnificationXref
id: P53779
db: uniprot

ncbitaxon 9606 20
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot O60674 19
type: UnificationXref
id: O60674
db: uniprot

IFNGR2 s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IFNGR2
stoichiometric coefficient: 1.0

Y701 STAT1 s9 sa7 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y701
feature location: Y701 STAT1 s9 sa7 rs1 Y701
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4619459670373214
comment: MODIFICATION_RESIDUE_NAME=Y701

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 44

PTHR10782:SF9
type: RelationshipXref
id: PTHR10782:SF9
db: PANTHER Family
relationship type: By Homology

uniprot B2WUP2 194
type: UnificationXref
id: B2WUP2
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63085 122
organism: Mus musculus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63086 123
organism: Rattus norvegicus

uniprot Q6P023 153
type: UnificationXref
id: Q6P023
db: uniprot

Serine kinase
type: Protein
entity reference: Serine kinase
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Jak1 s10 sa8 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.68

ncbitaxon 13616 16
type: UnificationXref
id: 13616
db: ncbitaxon

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot P53778 120
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A0D1C4Y4 43
organism: Ustilago maydis

Mitogen-activated protein kinase 10
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot P53779 121
organism: Homo sapiens

uniprot A0A3Q1LWJ8 52
type: UnificationXref
id: A0A3Q1LWJ8
db: uniprot

Suppressor of cytokine signaling 6
type: ProteinReference
xref: PTHR10155:SF17
xref: uniprot H9ERN5 213
organism: Macaca mulatta

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: uniprot F6WVD2 283
xref: PTHR46559:SF1
organism: Monodelphis domestica

uniprot A0A3Q1LJZ7 50
type: UnificationXref
id: A0A3Q1LJZ7
db: uniprot

Interferongamma s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Interferongamma
stoichiometric coefficient: 1.0

uniprot F1NMJ9 27
type: UnificationXref
id: F1NMJ9
db: uniprot

uniprot F1PMN2 69
type: UnificationXref
id: F1PMN2
db: uniprot

Mitogen-activated protein kinase 5
type: ProteinReference
xref: uniprot Q10N20 127
organism: Oryza sativa

uniprot A0A2I3TNY5 297
type: UnificationXref
id: A0A2I3TNY5
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot O23236 99
organism: Arabidopsis thaliana

Jak2 s16 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Jak2
stoichiometric coefficient: 1.0

Suppressor of cytokine signaling 4
type: ProteinReference
xref: uniprot Q0VC91 225
xref: PTHR10155:SF21
organism: Bos taurus

uniprot P29350 290
type: UnificationXref
id: P29350
db: uniprot

Mitogen-activated protein kinase (Fragment)
type: ProteinReference
xref: uniprot Q7PVR1 157
organism: Anopheles gambiae

ncbitaxon 3055 174
type: UnificationXref
id: 3055
db: ncbitaxon

IFNGR2 s24 a44 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.9136582736930956

Stress-activated protein kinase JNK
type: ProteinReference
xref: uniprot P92208 126
xref: PTHR24055:SF341
organism: Drosophila melanogaster

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot A0A3Q1LWJ8 52
organism: Bos taurus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A2I3TNY5 297
xref: PTHR11801:SF18
organism: Pan troglodytes

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 24

ncbitaxon 6239 114
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot D3ZS84 196
type: UnificationXref
id: D3ZS84
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

INHIBITION
type: RelationshipTypeVocabulary

uniprot F6WH53 15
type: UnificationXref
id: F6WH53
db: uniprot

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: uniprot F1Q3J6 282
xref: PTHR46559:SF1
organism: Canis lupus familiaris

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

ncbitaxon 237561 147
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot Q62225 227
type: UnificationXref
id: Q62225
db: uniprot

uniprot A0A2R8QL35 279
type: UnificationXref
id: A0A2R8QL35
db: uniprot

Tyrosine-protein phosphatase non-receptor type 11
type: ProteinReference
xref: uniprot P35235 292
xref: PTHR46559:SF1
organism: Mus musculus

STAT1
type: Protein
entity reference: STAT1
feature: S727 STAT1 s9 sa7 rs2
feature: ACTIVE 25
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa7 326
feature: Y701 STAT1 s9 sa7 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A3Q1ML58 244
type: UnificationXref
id: A0A3Q1ML58
db: uniprot

uniprot Q6Z437 154
type: UnificationXref
id: Q6Z437
db: uniprot

Protein inhibitor of activated STAT 2
type: ProteinReference
xref: PTHR10782:SF12
xref: uniprot E2RJ88 250
organism: Canis lupus familiaris

uniprot Q8N2W9 270
type: UnificationXref
id: Q8N2W9
db: uniprot

uniprot F6YAB9 80
type: UnificationXref
id: F6YAB9
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot F1N0D6 26
organism: Bos taurus

uniprot Q9LQQ9 177
type: UnificationXref
id: Q9LQQ9
db: uniprot

uniprot F7D8G7 206
type: UnificationXref
id: F7D8G7
db: uniprot

E3 SUMO-protein ligase PIAS3
type: ProteinReference
xref: PTHR10782:SF10
xref: uniprot O54714 263
organism: Mus musculus

uniprot P52332 35
type: UnificationXref
id: P52332
db: uniprot

Suppressor of cytokine signaling 4
type: ProteinReference
xref: PTHR10155:SF21
xref: uniprot Q91ZA6 233
organism: Mus musculus

uniprot Q8C5D8 269
type: UnificationXref
id: Q8C5D8
db: uniprot

uniprot G3V9T0 259
type: UnificationXref
id: G3V9T0
db: uniprot

uniprot F7FLL3 239
type: UnificationXref
id: F7FLL3
db: uniprot

Mitogen-activated protein kinase 18
type: ProteinReference
xref: uniprot Q9C5C0 168
organism: Arabidopsis thaliana

uniprot H2QLB4 92
type: UnificationXref
id: H2QLB4
db: uniprot

Cytokine-inducible SH2-containing protein
type: ProteinReference
xref: PTHR10155:SF9
xref: uniprot Q62225 227
organism: Mus musculus

uniprot P49708 41
type: UnificationXref
id: P49708
db: uniprot

uniprot Q94361 271
type: UnificationXref
id: Q94361
db: uniprot

uniprot Q39022 136
type: UnificationXref
id: Q39022
db: uniprot

uniprot E2RPW6 10
type: UnificationXref
id: E2RPW6
db: uniprot

Mitogen-activated protein kinase 15
type: ProteinReference
xref: uniprot Q11179 129
organism: Caenorhabditis elegans

uniprot O88583 224
type: UnificationXref
id: O88583
db: uniprot

uniprot H2QDZ6 210
type: UnificationXref
id: H2QDZ6
db: uniprot

uniprot O62618 104
type: UnificationXref
id: O62618
db: uniprot

Interferongamma
type: Protein
entity reference: Interferongamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa6 324
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q11179 129
type: UnificationXref
id: Q11179
db: uniprot

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Jak2
type: Protein
entity reference: Jak2
feature: ACTIVE 25
feature: Jak2 s16 sa14 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa14 312
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 20
type: ProteinReference
xref: uniprot Q9SJG9 182
organism: Arabidopsis thaliana

SOCS
type: Protein
entity reference: SOCS
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7E823 87
type: UnificationXref
id: F7E823
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 62

PARTICIPANT STOICHIOMETRY r29 366
type: Stoichiometry
physical entity: STAT1
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r29 367
type: Stoichiometry
physical entity: STAT1
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__Jak1-_ATP-RIGHT__Jak1-_ADP-_r32
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 363
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 364
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 365
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 362
left: Jak1
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: Jak1

STAT1
type: Protein
entity reference: STAT1
feature: Y701 STAT1 s49 a73 rs1
feature: S727 STAT1 s49 a73 rs2
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F1NMJ9 27
xref: PTHR45807:SF5
organism: Gallus gallus

uniprot F7GUL4 208
type: UnificationXref
id: F7GUL4
db: uniprot

Tyrosine-protein kinase JAK2
type: ProteinReference
xref: uniprot Q62689 23
xref: PTHR45807:SF1
organism: Rattus norvegicus

SOCS2 isoform 1
type: ProteinReference
xref: uniprot H2Q6L9 209
xref: PTHR10155:SF7
organism: Pan troglodytes

Y701 STAT1 s58 a90 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y701
feature location: Y701 STAT1 s58 a90 rs1 Y701
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4619459670373214
comment: MODIFICATION_RESIDUE_NAME=Y701

uniprot A0A3Q2TY19 53
type: UnificationXref
id: A0A3Q2TY19
db: uniprot

ncbitaxon 3702 100
type: UnificationXref
id: 3702
db: ncbitaxon

E3 SUMO-protein ligase PIAS2
type: ProteinReference
xref: PTHR10782:SF12
xref: uniprot O75928 266
organism: Homo sapiens

Interferon gamma
type: ProteinReference
xref: PTHR11419:SF0
xref: uniprot P63310 42
organism: Macaca mulatta

E3 SUMO-protein ligase PIAS1
type: ProteinReference
xref: PTHR10782:SF11
xref: uniprot O75925 265
organism: Homo sapiens

uniprot E2RKA7 66
type: UnificationXref
id: E2RKA7
db: uniprot

Mitogen-activated protein kinase 11
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot Q9WUI1 185
organism: Mus musculus

uniprot P42161 40
type: UnificationXref
id: P42161
db: uniprot

SOCS
type: ProteinReference
xref: P00956
standard name: Suppressor of cytokine signaling
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interferon-gamma signaling pathway.PROTEIN.GENERIC.SOCS
comment: ENTITY_REFERENCE_NOTES=Long Name: Suppressor of cytokine signaling Synonym: CIS,SOCS Accession: P00956
member entity reference: Suppressor of cytokine signaling 3
member entity reference: Suppressor of cytokine signaling 7
member entity reference: Suppressor of cytokine signaling 2
member entity reference: Cytokine inducible SH2 containing protein
member entity reference: RCG61633, isoform CRA_a
member entity reference: Suppressor of cytokine signaling 5
member entity reference: SOCS5 isoform 1
member entity reference: Suppressor of cytokine signaling 4
member entity reference: Suppressor of cytokine signaling 6
member entity reference: Suppressor of cytokine signaling at 36E, isoform D
member entity reference: Cytokine-inducible SH2-containing protein
member entity reference: CISH isoform 2
member entity reference: SOCS4 isoform 1
member entity reference: Suppressor of cytokine-signaling 5
member entity reference: Uncharacterized protein
member entity reference: SOCS2 isoform 1
member entity reference: Suppressor of cytokine-signaling 7
member entity reference: SOCS3 isoform 1
member entity reference: Suppressor of cytokine-signaling 6
member entity reference: SOCS6 isoform 1
member entity reference: Cish protein

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot G3V9W2 31
organism: Rattus norvegicus

Suppressor of cytokine signaling 3
type: ProteinReference
xref: uniprot Q90X67 232
xref: PTHR10155:SF11
organism: Gallus gallus

uniprot E2R2U8 249
type: UnificationXref
id: E2R2U8
db: uniprot

Pi
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Tyrosine-protein phosphatase non-receptor type 11
type: ProteinReference
xref: uniprot P41499 293
xref: PTHR46559:SF1
organism: Rattus norvegicus

uniprot D3ZUE4 197
type: UnificationXref
id: D3ZUE4
db: uniprot

Mitogen-activated protein kinase p38a
type: ProteinReference
xref: uniprot O62618 104
organism: Drosophila melanogaster

uniprot F7C798 85
type: UnificationXref
id: F7C798
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q7ZVK8 159
organism: Danio rerio

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 106

ncbitaxon 367110 189
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot V5IKE7 188
type: UnificationXref
id: V5IKE7
db: uniprot

uniprot Q63953 241
type: UnificationXref
id: Q63953
db: uniprot

Mitogen-activated protein kinase pmk-1
type: ProteinReference
xref: uniprot Q17446 132
organism: Caenorhabditis elegans

Interferongamma
type: Protein
entity reference: Interferongamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa12 308
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 103

Ifngr2 protein
type: ProteinReference
xref: uniprot Q63953 241
xref: PTHR20859:SF46
organism: Mus musculus

uniprot P47811 117
type: UnificationXref
id: P47811
db: uniprot

uniprot K7AQ66 261
type: UnificationXref
id: K7AQ66
db: uniprot

Mitogen-activated protein kinase KSS1
type: ProteinReference
xref: uniprot P14681 105
organism: Saccharomyces cerevisiae

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A0A1D5PXC6 46
organism: Gallus gallus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A8X1S0 60
xref: PTHR24055:SF341
organism: Caenorhabditis briggsae

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 156

PTHR11419:SF0
type: RelationshipXref
id: PTHR11419:SF0
db: PANTHER Family
relationship type: By Homology

uniprot O23236 99
type: UnificationXref
id: O23236
db: uniprot

uniprot F6YVE7 203
type: UnificationXref
id: F6YVE7
db: uniprot

uniprot Q39027 140
type: UnificationXref
id: Q39027
db: uniprot

uniprot O54714 263
type: UnificationXref
id: O54714
db: uniprot

Suppressor of cytokine signaling 5
type: ProteinReference
xref: PTHR10155:SF15
xref: uniprot O54928 221
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot Q6P023 153
organism: Danio rerio

IFNGR2
type: Protein
entity reference: IFNGR2
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa11 306
feature: IFNGR2 s13 sa11 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Tyrosine-protein phosphatase non-receptor type 6
type: ProteinReference
xref: uniprot P29350 290
xref: PTHR46257:SF4
organism: Homo sapiens

Tyrosine-protein phosphatase non-receptor type 6
type: ProteinReference
xref: uniprot P29351 291
xref: PTHR46257:SF4
organism: Mus musculus

Mitogen-activated protein kinase 10
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot Q61831 150
organism: Mus musculus

uniprot A0A2I3SYV7 4
type: UnificationXref
id: A0A2I3SYV7
db: uniprot

uniprot P41499 293
type: UnificationXref
id: P41499
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F1P630 68
organism: Canis lupus familiaris

uniprot F7DDM9 254
type: UnificationXref
id: F7DDM9
db: uniprot

uniprot A0A3Q1LPE8 243
type: UnificationXref
id: A0A3Q1LPE8
db: uniprot

uniprot O75159 222
type: UnificationXref
id: O75159
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 75

Protein inhibitor of activated STAT 1 (Predicted)
type: ProteinReference
xref: uniprot G3V9T0 259
xref: PTHR10782:SF11
organism: Rattus norvegicus

E3 SUMO-protein ligase PIAS3
type: ProteinReference
xref: uniprot Q9Y6X2 273
xref: PTHR10782:SF10
organism: Homo sapiens

uniprot P45984 116
type: UnificationXref
id: P45984
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10782:SF12
xref: uniprot F7DDM9 254
organism: Monodelphis domestica

IFNGR1
type: Protein
entity reference: IFNGR1
feature: IFNGR1 s1 sa1 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 314
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9LQQ9 177
organism: Arabidopsis thaliana

Suppressor of cytokine-signaling 6
type: ProteinReference
xref: PTHR10155:SF17
xref: uniprot D3ZS84 196
organism: Rattus norvegicus

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: uniprot A0A3Q1M739 280
xref: PTHR46257:SF4
organism: Bos taurus

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F1PIY7 29
xref: PTHR45807:SF5
organism: Canis lupus familiaris

Tyrosine-protein phosphatase corkscrew
type: ProteinReference
xref: uniprot P29349 289
xref: PTHR46257:SF3
organism: Drosophila melanogaster

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2R0G7 94
xref: PTHR24055:SF222
organism: Pan troglodytes

Cytokine-inducible SH2-containing protein
type: ProteinReference
xref: PTHR10155:SF9
xref: uniprot Q2HJ53 226
organism: Bos taurus

Suppressor of cytokine signaling 5
type: ProteinReference
xref: PTHR10155:SF15
xref: uniprot B2WUP1 193
organism: Gallus gallus

Suppressor of cytokine signaling 6
type: ProteinReference
xref: PTHR10155:SF27
xref: uniprot B2WUP2 194
organism: Gallus gallus

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: uniprot A0A1D5QYU2 278
xref: PTHR46559:SF1
organism: Macaca mulatta

IFNGR2 s2 sa2 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.9136582736930956

ncbitaxon 665079 56
type: UnificationXref
id: 665079
db: ncbitaxon

uniprot A0A1D5QYU2 278
type: UnificationXref
id: A0A1D5QYU2
db: uniprot

uniprot Q9FXT7 173
type: UnificationXref
id: Q9FXT7
db: uniprot

uniprot Q6P943 300
type: UnificationXref
id: Q6P943
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q9FXT7 173
organism: Chlamydomonas reinhardtii

IFNGR2
type: ProteinReference
xref: P00957
standard name: Interferon-gamma receptor
comment: ENTITY_REFERENCE_ID_DESC=Interferon-gamma signaling pathway.PROTEIN.RECEPTOR.IFNGR2
comment: ENTITY_REFERENCE_NOTES=Long Name: IFNGR2 Synonym: Synonym not specified Accession: P00957
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Ifngr2 protein
member entity reference: IFNGR2 isoform 3
member entity reference: Interferon gamma receptor 2
member entity reference: Uncharacterized protein

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: PTHR46257:SF1
xref: uniprot A0A2R8QL35 279
organism: Danio rerio

uniprot A0A2I3RZ31 49
type: UnificationXref
id: A0A2I3RZ31
db: uniprot

uniprot F1PXS7 70
type: UnificationXref
id: F1PXS7
db: uniprot

Jak2
type: ProteinReference
xref: P00952
standard name: Janus kinase 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interferon-gamma signaling pathway.PROTEIN.GENERIC.Jak2
comment: ENTITY_REFERENCE_NOTES=Long Name: Janus kinase 2 Synonym: Jak2 Accession: P00952
member entity reference: Tyrosine-protein kinase
member entity reference: Tyrosine-protein kinase JAK2

Protein inhibitor of activated STAT 1
type: ProteinReference
xref: uniprot F1PQ60 252
xref: PTHR10782:SF11
organism: Canis lupus familiaris

Interferongamma s8 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Interferongamma
stoichiometric coefficient: 1.0

Suppressor of cytokine signaling 4
type: ProteinReference
xref: PTHR10155:SF21
xref: uniprot Q8WXH5 231
organism: Homo sapiens

uniprot Q6AZ28 268
type: UnificationXref
id: Q6AZ28
db: uniprot

TRANSPORT_LEFT__STAT1-RIGHT__STAT1-_r29
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 366
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 367
left: STAT1
interaction type: TRANSPORT
right: STAT1

IFNGR2 s7 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IFNGR2
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P49186 118
organism: Rattus norvegicus

ncbitaxon 6238 59
type: UnificationXref
id: 6238
db: ncbitaxon

Mitogen-activated protein kinase 10
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot P49187 119
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6TKL3 74
organism: Xenopus tropicalis

Interferon gamma receptor 1
type: ProteinReference
xref: uniprot Q6P6T3 277
xref: PTHR20859:SF5
organism: Rattus norvegicus

uniprot Q39021 135
type: UnificationXref
id: Q39021
db: uniprot

uniprot P01579 36
type: UnificationXref
id: P01579
db: uniprot

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__STAT1-_2_ATP-_Complex__IFNGR1_IFNGR2__Interferongamma_Jak1__Jak2_-RIGHT__2_ADP-_Complex__IFNGR1_IFNGR2__Interferongamma_STAT1__Jak1_Jak2_-_r51
controller: Jak2

E3 SUMO-protein ligase gei-17
type: ProteinReference
xref: uniprot Q94361 271
organism: Caenorhabditis elegans

uniprot P07353 39
type: UnificationXref
id: P07353
db: uniprot

uniprot F1N0D6 26
type: UnificationXref
id: F1N0D6
db: uniprot

IFNGR1 isoform 4
type: ProteinReference
xref: uniprot H2R6X1 274
xref: PTHR20859:SF5
organism: Pan troglodytes

PTHR45807:SF2
type: RelationshipXref
id: PTHR45807:SF2
db: PANTHER Family
relationship type: By Homology

Y701 STAT1 s21 a28 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y701
feature location: Y701 STAT1 s21 a28 rs1 Y701
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4619459670373214
comment: MODIFICATION_RESIDUE_NAME=Y701

PTHR45807:SF1
type: RelationshipXref
id: PTHR45807:SF1
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot Q9LV37 179
organism: Arabidopsis thaliana

PTHR45807:SF5
type: RelationshipXref
id: PTHR45807:SF5
db: PANTHER Family
relationship type: By Homology

uniprot Q8WXH5 231
type: UnificationXref
id: Q8WXH5
db: uniprot

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__STAT1-_2_ATP-_Complex__IFNGR1_IFNGR2__Interferongamma_Jak1__Jak2_-RIGHT__2_ADP-_Complex__IFNGR1_IFNGR2__Interferongamma_STAT1__Jak1_Jak2_-_r51
controller: Serine kinase

GO GO:0005634 3
type: UnificationXref
id: GO:0005634
db: GO

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF9
xref: uniprot F7BFK3 205
organism: Macaca mulatta

uniprot Q90687 295
type: UnificationXref
id: Q90687
db: uniprot

uniprot O75928 266
type: UnificationXref
id: O75928
db: uniprot

Suppressor of cytokine-signaling 5
type: ProteinReference
xref: PTHR10155:SF15
xref: uniprot F1MWV6 200
organism: Bos taurus

Gene transcription
type: Pathway

Tyrosine-protein kinase JAK1
type: ProteinReference
xref: uniprot P23458 34
xref: PTHR45807:SF5
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__Complex__IFNGR1_IFNGR2__Interferongamma_-_Jak1-_ATP-_Jak2-RIGHT__ADP-_Complex__IFNGR1_IFNGR2__Interferongamma_Jak1__Jak2_-_r48
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 337
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 338
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 336
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 339
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 340
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 341
left: Complex (IFNGR1/IFNGR2/ Interferongamma)
left: Jak1
left: Jak2
left: ATP
interaction type: HETERODIMER_ASSOCIATION
right: ADP
right: Complex (IFNGR1/IFNGR2/ Interferongamma/Jak1/ Jak2)

Jak1 s15 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Jak1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Jak2-RIGHT__Jak2-_Pi-_r36
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 353
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 354
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 352
left: Jak2
interaction type: STATE_TRANSITION
right: Pi
right: Jak2

S727 STAT1 s59 a91 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S727
feature location: S727 STAT1 s59 a91 rs2 S727
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S727
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.9089356867941967

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E1B8P9 64
xref: PTHR24055:SF393
organism: Bos taurus

Interferon gamma
type: ProteinReference
xref: uniprot P01579 36
xref: PTHR11419:SF0
organism: Homo sapiens

Interferon gamma receptor 2
type: ProteinReference
xref: uniprot P38484 240
xref: PTHR20859:SF46
organism: Homo sapiens

Bos taurus
type: BioSource
xref: ncbitaxon 9913 9

uniprot F6WVD2 283
type: UnificationXref
id: F6WVD2
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 84

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q5SN53 148
organism: Oryza sativa

uniprot P70618 124
type: UnificationXref
id: P70618
db: uniprot

uniprot Q9N272 181
type: UnificationXref
id: Q9N272
db: uniprot

uniprot Q91ZA6 233
type: UnificationXref
id: Q91ZA6
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__IFNGR2-_IFNGR1-_Interferongamma-RIGHT__Complex__IFNGR1_IFNGR2__Interferongamma_-_r45
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 348
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 347
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 345
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 346
left: Interferongamma
left: IFNGR1
left: IFNGR2
interaction type: HETERODIMER_ASSOCIATION
right: Complex (IFNGR1/IFNGR2/ Interferongamma)

uniprot P63085 122
type: UnificationXref
id: P63085
db: uniprot

uniprot F1Q3J6 282
type: UnificationXref
id: F1Q3J6
db: uniprot

STATE_TRANSITION_LEFT__Jak2-_ATP-RIGHT__ADP-_Jak2-_r33
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 359
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 361
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 360
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 358
left: Jak2
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: Jak2

Interferon gamma
type: ProteinReference
xref: uniprot P01580 37
xref: PTHR11419:SF0
organism: Mus musculus

ncbitaxon 7955 13
type: UnificationXref
id: 7955
db: ncbitaxon

Interferon gamma
type: ProteinReference
xref: PTHR11419:SF0
xref: uniprot P01581 38
organism: Rattus norvegicus

Suppressor of cytokine signaling 7
type: ProteinReference
xref: PTHR10155:SF5
xref: uniprot E1BIS1 198
organism: Bos taurus

E3 SUMO-protein ligase PIAS1
type: ProteinReference
xref: uniprot O88907 267
xref: PTHR10782:SF11
organism: Mus musculus

SOCS6 isoform 1
type: ProteinReference
xref: PTHR10155:SF17
xref: uniprot H2QEP3 211
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E823 87
xref: PTHR24055:SF203
organism: Monodelphis domestica

IFNGR1
type: Protein
entity reference: IFNGR1
feature: IFNGR1 s23 a43 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9M1Z5 180
type: UnificationXref
id: Q9M1Z5
db: uniprot

uniprot A0A3Q1M739 280
type: UnificationXref
id: A0A3Q1M739
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 11

Jak1 s15 sa13 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.68

PARTICIPANT STOICHIOMETRY r35 355
type: Stoichiometry
physical entity: Jak1
stoichiometric coefficient: 1.0

uniprot O88907 267
type: UnificationXref
id: O88907
db: uniprot

PARTICIPANT STOICHIOMETRY r35 357
type: Stoichiometry
physical entity: Jak1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r35 356
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

Cytokine-inducible SH2-containing protein
type: ProteinReference
xref: uniprot Q9NSE2 236
xref: PTHR10155:SF9
organism: Homo sapiens

2 ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Suppressor of cytokine signaling 2
type: ProteinReference
xref: PTHR10155:SF7
xref: uniprot O88582 223
organism: Rattus norvegicus

Suppressor of cytokine signaling 3
type: ProteinReference
xref: PTHR10155:SF11
xref: uniprot O88583 224
organism: Rattus norvegicus

PTHR20859:SF5
type: RelationshipXref
id: PTHR20859:SF5
db: PANTHER Family
relationship type: By Homology

Extracellular signal-regulated kinase 2
type: ProteinReference
xref: uniprot Q54QB1 144
organism: Dictyostelium discoideum

uniprot A1Z7P5 245
type: UnificationXref
id: A1Z7P5
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 28

uniprot O88582 223
type: UnificationXref
id: O88582
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F7GT47 17
xref: PTHR45807:SF1
organism: Macaca mulatta

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF1
xref: uniprot E1BCP6 8
organism: Bos taurus

uniprot Q8INY1 229
type: UnificationXref
id: Q8INY1
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q9LM33 175
organism: Arabidopsis thaliana

uniprot E2RSB0 67
type: UnificationXref
id: E2RSB0
db: uniprot

uniprot P39745 113
type: UnificationXref
id: P39745
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7EH19 88
organism: Xenopus tropicalis

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Jak1-_ATP-RIGHT__Jak1-_ADP-_r32
control type: INHIBITION
controller: SOCS

Interferon gamma receptor 1
type: ProteinReference
xref: uniprot P15261 276
xref: PTHR20859:SF5
organism: Mus musculus

Interferon gamma receptor 1
type: ProteinReference
xref: PTHR20859:SF5
xref: uniprot P15260 275
organism: Homo sapiens

Protein inhibitor of-activated STAT 1
type: ProteinReference
xref: PTHR10782:SF11
xref: uniprot F6YUL3 253
organism: Xenopus tropicalis

IFNGR2 s13 sa11 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.9136582736930956

uniprot P29351 291
type: UnificationXref
id: P29351
db: uniprot

Pi
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

S727 STAT1 s21 a28 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S727
feature location: S727 STAT1 s21 a28 rs2 S727
comment: MODIFICATION_RESIDUE_NAME=S727
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.9089356867941967

S727 STAT1 s49 a73 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S727
feature location: S727 STAT1 s49 a73 rs2 S727
comment: MODIFICATION_RESIDUE_NAME=S727
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.9089356867941967

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F6WH53 15
xref: PTHR45807:SF1
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: PTHR10782:SF11
xref: uniprot F1NSG6 251
organism: Gallus gallus

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot A0A2I3SYV7 4
xref: PTHR45807:SF1
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Jak2-_ATP-RIGHT__ADP-_Jak2-_r33
controller: Jak1

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot P70618 124
organism: Rattus norvegicus

uniprot P42225 299
type: UnificationXref
id: P42225
db: uniprot

Mitogen-activated protein kinase 15
type: ProteinReference
xref: uniprot Q9C9U4 169
organism: Arabidopsis thaliana

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Jak1-_ATP-RIGHT__Jak1-_ADP-_r32
controller: Jak2

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot H2PZ66 32
organism: Pan troglodytes

Tyrosine-protein kinase JAK2
type: ProteinReference
xref: uniprot O60674 19
xref: PTHR45807:SF1
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6R8N9 73
organism: Macaca mulatta

uniprot Q10N20 127
type: UnificationXref
id: Q10N20
db: uniprot

ncbitaxon 559292 106
type: UnificationXref
id: 559292
db: ncbitaxon

Mitogen-activated protein kinase 15
type: ProteinReference
xref: PTHR24055:SF79
xref: uniprot Q8TD08 163
organism: Homo sapiens

uniprot B5DFF9 248
type: UnificationXref
id: B5DFF9
db: uniprot

uniprot O02812 96
type: UnificationXref
id: O02812
db: uniprot

uniprot Q9LV37 179
type: UnificationXref
id: Q9LV37
db: uniprot

Suppressor of cytokine signaling 2
type: ProteinReference
xref: PTHR10155:SF7
xref: uniprot Q861R0 228
organism: Bos taurus

Suppressor of cytokine signaling 5
type: ProteinReference
xref: PTHR10155:SF15
xref: uniprot F7GUL4 208
organism: Macaca mulatta

Jak1
type: Protein
entity reference: Jak1
feature: Jak1 s4 a6 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 128

uniprot F6V332 77
type: UnificationXref
id: F6V332
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot Q6P943 300
xref: PTHR11801:SF18
organism: Danio rerio

Jak2 s16 sa14 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.82
comment: MODIFICATION_RESIDUE_NAME=

uniprot F6TKL3 74
type: UnificationXref
id: F6TKL3
db: uniprot

uniprot Q8TD08 163
type: UnificationXref
id: Q8TD08
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot A0A3Q1LJZ7 50
organism: Bos taurus

uniprot E1B8P9 64
type: UnificationXref
id: E1B8P9
db: uniprot

Mitogen-activated protein kinase pmk-2
type: ProteinReference
xref: uniprot Q8MXI4 162
organism: Caenorhabditis elegans

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 158

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A2I3RZ31 49
xref: PTHR24055:SF162
organism: Pan troglodytes

uniprot Q9NSE2 236
type: UnificationXref
id: Q9NSE2
db: uniprot

Interferon gamma
type: ProteinReference
xref: PTHR11419:SF0
xref: uniprot P42161 40
organism: Canis lupus familiaris

P00958
type: UnificationXref
id: P00958
db: PANTHER Pathway Component

P00959
type: UnificationXref
id: P00959
db: PANTHER Pathway Component

uniprot A0A0G2K9S1 190
type: UnificationXref
id: A0A0G2K9S1
db: uniprot

PIAS
type: Protein
entity reference: PIAS
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

P00952
type: UnificationXref
id: P00952
db: PANTHER Pathway Component

RCG61633, isoform CRA_a
type: ProteinReference
xref: PTHR10155:SF15
xref: uniprot D3ZUE4 197
organism: Rattus norvegicus

P00953
type: UnificationXref
id: P00953
db: PANTHER Pathway Component

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RSB0 67
xref: PTHR24055:SF146
organism: Canis lupus familiaris

P00954
type: UnificationXref
id: P00954
db: PANTHER Pathway Component

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot Q91Y86 166
organism: Mus musculus

P00955
type: UnificationXref
id: P00955
db: PANTHER Pathway Component

Protein inhibitor of activated STAT 1
type: ProteinReference
xref: uniprot F7DN97 255
xref: PTHR10782:SF11
organism: Ornithorhynchus anatinus

P00956
type: UnificationXref
id: P00956
db: PANTHER Pathway Component

uniprot Q5SN53 148
type: UnificationXref
id: Q5SN53
db: uniprot

P00957
type: UnificationXref
id: P00957
db: PANTHER Pathway Component

uniprot B1WBX9 192
type: UnificationXref
id: B1WBX9
db: uniprot

P00960
type: UnificationXref
id: P00960
db: PANTHER Pathway Component

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9WTY9 184
xref: PTHR24055:SF107
organism: Rattus norvegicus

IFNGR2 isoform 3
type: ProteinReference
xref: uniprot A0A2I3S1N2 238
xref: PTHR20859:SF46
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Jak2-RIGHT__Jak2-_Pi-_r36
controller: PTP

IFNGR1
type: ProteinReference
xref: P00959
standard name: Interferon-gamma receptor
comment: ENTITY_REFERENCE_ID_DESC=Interferon-gamma signaling pathway.PROTEIN.RECEPTOR.IFNGR1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
comment: ENTITY_REFERENCE_NOTES=Long Name: IFNGR1 Synonym: Synonym not specified Accession: P00959
member entity reference: Interferon gamma receptor 1
member entity reference: IFNGR1 isoform 4
member entity reference: Ifngr2 protein
member entity reference: IFNGR2 isoform 3
member entity reference: Interferon gamma receptor 2
member entity reference: Uncharacterized protein

ncbitaxon 39947 128
type: UnificationXref
id: 39947
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UUY8 202
xref: PTHR10155:SF11
organism: Macaca mulatta

uniprot H2QS62 93
type: UnificationXref
id: H2QS62
db: uniprot

PTHR24055:SF109
type: RelationshipXref
id: PTHR24055:SF109
db: PANTHER Family
relationship type: By Homology

PTHR24055:SF107
type: RelationshipXref
id: PTHR24055:SF107
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5R9X3 296
type: UnificationXref
id: A0A1D5R9X3
db: uniprot

P00961
type: UnificationXref
id: P00961
db: PANTHER Pathway Component

uniprot Q8WQG9 165
type: UnificationXref
id: Q8WQG9
db: uniprot

uniprot A0A1D5Q5Z6 47
type: UnificationXref
id: A0A1D5Q5Z6
db: uniprot

Interferongamma
type: Protein
entity reference: Interferongamma
comment: SPECIES_TYPE=PROTEIN

uniprot Q9C9U4 169
type: UnificationXref
id: Q9C9U4
db: uniprot

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__STAT1-_2_ATP-_Complex__IFNGR1_IFNGR2__Interferongamma_Jak1__Jak2_-RIGHT__2_ADP-_Complex__IFNGR1_IFNGR2__Interferongamma_STAT1__Jak1_Jak2_-_r51
controller: Jak1

uniprot H9FNP4 260
type: UnificationXref
id: H9FNP4
db: uniprot

uniprot Q9JM05 272
type: UnificationXref
id: Q9JM05
db: uniprot

uniprot F7GFM9 257
type: UnificationXref
id: F7GFM9
db: uniprot

uniprot P49187 119
type: UnificationXref
id: P49187
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A7EJF2 55
organism: Sclerotinia sclerotiorum

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot F1PMN2 69
organism: Canis lupus familiaris

IFNGR1 s1 sa1 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.464466147903891

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: STAT1

uniprot O35718 220
type: UnificationXref
id: O35718
db: uniprot

uniprot Q8W4J2 164
type: UnificationXref
id: Q8W4J2
db: uniprot

Mitogen-activated protein kinase 15
type: ProteinReference
xref: uniprot Q9Z2A6 187
xref: PTHR24055:SF79
organism: Rattus norvegicus

Tyrosine-protein kinase JAK1
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot P52332 35
organism: Mus musculus

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 111

uniprot F7AZP2 204
type: UnificationXref
id: F7AZP2
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7FHD1 90
organism: Monodelphis domestica

uniprot Q7ZVK8 159
type: UnificationXref
id: Q7ZVK8
db: uniprot

uniprot A7F3M0 57
type: UnificationXref
id: A7F3M0
db: uniprot

uniprot F6YUL3 253
type: UnificationXref
id: F6YUL3
db: uniprot

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__STAT1-RIGHT__STAT1-_Pi-_r41
controller: PIAS

uniprot O42376 101
type: UnificationXref
id: O42376
db: uniprot

uniprot C8V7D1 61
type: UnificationXref
id: C8V7D1
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot O02812 96
organism: Canis lupus familiaris

uniprot H2RA86 95
type: UnificationXref
id: H2RA86
db: uniprot

PTP
type: Protein
entity reference: PTP
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

DISSOCIATION
type: InteractionVocabulary

uniprot Q3T0N5 141
type: UnificationXref
id: Q3T0N5
db: uniprot

uniprot O08911 97
type: UnificationXref
id: O08911
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RKA7 66
xref: PTHR24055:SF107
organism: Canis lupus familiaris

uniprot E1BIS1 198
type: UnificationXref
id: E1BIS1
db: uniprot

uniprot O14544 218
type: UnificationXref
id: O14544
db: uniprot

uniprot Q9BEG9 234
type: UnificationXref
id: Q9BEG9
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F5HEA9 71
organism: Phaeosphaeria nodorum

uniprot F7CYE3 86
type: UnificationXref
id: F7CYE3
db: uniprot

uniprot Q39024 138
type: UnificationXref
id: Q39024
db: uniprot

uniprot F1MWV6 200
type: UnificationXref
id: F1MWV6
db: uniprot

Interferongamma
type: Protein
entity reference: Interferongamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 318
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PIAS3 isoform 4
type: ProteinReference
xref: uniprot K7AQ66 261
xref: PTHR10782:SF10
organism: Pan troglodytes

Jak1
type: Protein
entity reference: Jak1
feature: ACTIVE 25
feature: Jak1 s10 sa8 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa8 328
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1P630 68
type: UnificationXref
id: F1P630
db: uniprot

uniprot H2R0G7 94
type: UnificationXref
id: H2R0G7
db: uniprot

Jak1
type: Protein
entity reference: Jak1
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa13 310
feature: ACTIVE 25
feature: Jak1 s15 sa13 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

IFNGR1 s5 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IFNGR1
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 20

PTHR24055:SF110
type: RelationshipXref
id: PTHR24055:SF110
db: PANTHER Family
relationship type: By Homology

Jak2
type: Protein
entity reference: Jak2
feature: Jak2 s6 a7 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 227321 62
type: UnificationXref
id: 227321
db: ncbitaxon

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot Q9WTU6 183
organism: Mus musculus

PTHR24055:SF341
type: RelationshipXref
id: PTHR24055:SF341
db: PANTHER Family
relationship type: By Homology

SOCS4 isoform 1
type: ProteinReference
xref: PTHR10155:SF21
xref: uniprot K7BMJ0 214
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10782:SF12
xref: uniprot F7GFM9 257
organism: Macaca mulatta

By Homology
type: RelationshipTypeVocabulary

uniprot Q9WUI1 185
type: UnificationXref
id: Q9WUI1
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6Y4G8 79
organism: Canis lupus familiaris

PTHR10782:SF12
type: RelationshipXref
id: PTHR10782:SF12
db: PANTHER Family
relationship type: By Homology

uniprot D4A3U7 63
type: UnificationXref
id: D4A3U7
db: uniprot

uniprot P28482 112
type: UnificationXref
id: P28482
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q9N272 181
organism: Pan troglodytes

uniprot A6QQU9 247
type: UnificationXref
id: A6QQU9
db: uniprot

PTHR24055:SF146
type: RelationshipXref
id: PTHR24055:SF146
db: PANTHER Family
relationship type: By Homology

PTHR10782:SF10
type: RelationshipXref
id: PTHR10782:SF10
db: PANTHER Family
relationship type: By Homology

PTHR10782:SF11
type: RelationshipXref
id: PTHR10782:SF11
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot Q84UI5 161
organism: Oryza sativa

uniprot P35235 292
type: UnificationXref
id: P35235
db: uniprot

Pias4 protein
type: ProteinReference
xref: PTHR10782:SF9
xref: uniprot B5DFF9 248
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6TXC2 76
xref: PTHR24055:SF107
organism: Monodelphis domestica

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot V5IKE7 188
organism: Neurospora crassa

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: uniprot H2R7K2 286
xref: PTHR46257:SF4
organism: Pan troglodytes

uniprot Q9PW70 237
type: UnificationXref
id: Q9PW70
db: uniprot

ncbitaxon 10116 24
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot F7GT47 17
type: UnificationXref
id: F7GT47
db: uniprot

Suppressor of cytokine signaling 2
type: ProteinReference
xref: PTHR10155:SF7
xref: uniprot F7E320 207
organism: Macaca mulatta

Tyrosine-protein kinase JAK2
type: ProteinReference
xref: uniprot Q62120 21
xref: PTHR45807:SF1
organism: Mus musculus

PTHR24055:SF162
type: RelationshipXref
id: PTHR24055:SF162
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6V332 77
xref: PTHR24055:SF110
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot A0A3Q1LTT9 51
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot A0A1D5QUZ8 48
organism: Macaca mulatta

uniprot H2RIH8 287
type: UnificationXref
id: H2RIH8
db: uniprot

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 145

uniprot Q90X67 232
type: UnificationXref
id: Q90X67
db: uniprot

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A3Q1LTT9 51
type: UnificationXref
id: A0A3Q1LTT9
db: uniprot

uniprot O35717 219
type: UnificationXref
id: O35717
db: uniprot

PIAS2 isoform 1
type: ProteinReference
xref: PTHR10782:SF12
xref: uniprot K7B8T0 262
organism: Pan troglodytes

Tyrosine-protein phosphatase non-receptor type 6
type: ProteinReference
xref: uniprot P81718 294
xref: PTHR46257:SF4
organism: Rattus norvegicus

uniprot P45983 115
type: UnificationXref
id: P45983
db: uniprot

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 134

HETERODIMER_ASSOCIATION_LEFT__STAT1-_2_ATP-_Complex__IFNGR1_IFNGR2__Interferongamma_Jak1__Jak2_-RIGHT__2_ADP-_Complex__IFNGR1_IFNGR2__Interferongamma_STAT1__Jak1_Jak2_-_r51
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 334
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 332
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 331
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 335
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 333
left: STAT1
left: Complex (IFNGR1/IFNGR2/ Interferongamma/Jak1/ Jak2)
left: 2 ATP
interaction type: HETERODIMER_ASSOCIATION
right: Complex (IFNGR1/IFNGR2/ Interferongamma/STAT1/ Jak1/Jak2)
right: 2 ADP

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 14

E3 SUMO-protein ligase PIAS4
type: ProteinReference
xref: PTHR10782:SF9
xref: uniprot Q8N2W9 270
organism: Homo sapiens

E3 SUMO-protein ligase PIAS3
type: ProteinReference
xref: PTHR10782:SF10
xref: uniprot H9FNP4 260
organism: Macaca mulatta

DISSOCIATION_LEFT__STAT1-RIGHT__STAT1-_Pi-_r41
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 351
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 350
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 349
left: STAT1
interaction type: DISSOCIATION
right: Pi
right: STAT1

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q6Z437 154
organism: Oryza sativa

ncbitaxon 9615 11
type: UnificationXref
id: 9615
db: ncbitaxon

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot F6YLX1 30
organism: Macaca mulatta

STAT1
type: Protein
entity reference: STAT1
feature: S727 STAT1 s21 a28 rs2
feature: Y701 STAT1 s21 a28 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot B2WUP1 193
type: UnificationXref
id: B2WUP1
db: uniprot

uniprot F7HEF3 258
type: UnificationXref
id: F7HEF3
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot H2QLB4 92
organism: Pan troglodytes

uniprot Q0VC91 225
type: UnificationXref
id: Q0VC91
db: uniprot

uniprot A4FV00 54
type: UnificationXref
id: A4FV00
db: uniprot

PTHR24055:SF172
type: RelationshipXref
id: PTHR24055:SF172
db: PANTHER Family
relationship type: By Homology

Interferon gamma
type: ProteinReference
xref: PTHR11419:SF0
xref: uniprot P07353 39
organism: Bos taurus

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q3T0N5 141
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5Q5Z6 47
xref: PTHR24055:SF393
organism: Macaca mulatta

uniprot H2QEP3 211
type: UnificationXref
id: H2QEP3
db: uniprot

uniprot Q91Y86 166
type: UnificationXref
id: Q91Y86
db: uniprot

uniprot F6R8N9 73
type: UnificationXref
id: F6R8N9
db: uniprot

Tyrosine-protein phosphatase non-receptor type 11
type: ProteinReference
xref: PTHR46559:SF3
xref: uniprot Q90687 295
organism: Gallus gallus

Suppressor of cytokine signaling 3
type: ProteinReference
xref: PTHR10155:SF11
xref: uniprot Q9BEG9 234
organism: Bos taurus

PTHR10155:SF27
type: RelationshipXref
id: PTHR10155:SF27
db: PANTHER Family
relationship type: By Homology

uniprot P15261 276
type: UnificationXref
id: P15261
db: uniprot

PTHR10155:SF21
type: RelationshipXref
id: PTHR10155:SF21
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION
type: InteractionVocabulary

uniprot O12990 33
type: UnificationXref
id: O12990
db: uniprot

TRANSPORT
type: InteractionVocabulary

ncbitaxon 9913 9
type: UnificationXref
id: 9913
db: ncbitaxon

IFNGR1 s23 a43 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.464466147903891

Jak2
type: Protein
entity reference: Jak2
feature: ACTIVE 25
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa9 330
feature: Jak2 s11 sa9 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q16539 131
xref: PTHR24055:SF110
organism: Homo sapiens

uniprot Q7KQK7 155
type: UnificationXref
id: Q7KQK7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FLL3 239
xref: PTHR20859:SF46
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A0A0R4IKK9 45
organism: Danio rerio

IFNGR1
type: Protein
entity reference: IFNGR1
feature: IFNGR1 s5 sa4 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa4 320
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Candida albicans
type: BioSource
xref: ncbitaxon 237561 147

PTHR10155:SF17
type: RelationshipXref
id: PTHR10155:SF17
db: PANTHER Family
relationship type: By Homology

Extracellular signal-regulated kinase 1
type: ProteinReference
xref: uniprot Q5A1D3 146
organism: Candida albicans

E3 SUMO-protein ligase PIAS1
type: ProteinReference
xref: PTHR10782:SF11
xref: uniprot F7HEF3 258
organism: Macaca mulatta

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

PTHR10155:SF11
type: RelationshipXref
id: PTHR10155:SF11
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase JAK1
type: ProteinReference
xref: uniprot O12990 33
xref: PTHR45807:SF5
organism: Danio rerio

PANTHER Pathway P00035 1
type: UnificationXref
id: P00035
db: PANTHER Pathway

PTHR10155:SF15
type: RelationshipXref
id: PTHR10155:SF15
db: PANTHER Family
relationship type: By Homology

Cytokine inducible SH2 containing protein
type: ProteinReference
xref: PTHR10155:SF9
xref: uniprot F1PSF4 201
organism: Canis lupus familiaris

Leishmania major
type: BioSource
xref: ncbitaxon 5664 143

Protein inhibitor of activated STAT 1
type: ProteinReference
xref: PTHR10782:SF11
xref: uniprot A0A3Q1ML58 244
organism: Bos taurus

Jak1 s64 a92 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.68

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A7F3M0 57
organism: Sclerotinia sclerotiorum

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

uniprot F7E320 207
type: UnificationXref
id: F7E320
db: uniprot

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 72

uniprot H2PZ66 32
type: UnificationXref
id: H2PZ66
db: uniprot

Jak1
type: Protein
entity reference: Jak1
feature: Jak1 s64 a92 rs1
feature: ACTIVE 25
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E2RPW6 10
xref: PTHR45807:SF1
organism: Canis lupus familiaris

PTP
type: Protein
entity reference: PTP
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9DGD9 170
type: UnificationXref
id: Q9DGD9
db: uniprot

uniprot F6WV79 78
type: UnificationXref
id: F6WV79
db: uniprot

uniprot F1NSG6 251
type: UnificationXref
id: F1NSG6
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot F7GN93 91
organism: Macaca mulatta

uniprot Q9DGE1 171
type: UnificationXref
id: Q9DGE1
db: uniprot

Suppressor of cytokine signaling 7
type: ProteinReference
xref: PTHR10155:SF5
xref: uniprot Q8VHQ2 230
organism: Mus musculus

uniprot P01581 38
type: UnificationXref
id: P01581
db: uniprot

PTHR24055:SF79
type: RelationshipXref
id: PTHR24055:SF79
db: PANTHER Family
relationship type: By Homology

IFNGR2 s13 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IFNGR2
stoichiometric coefficient: 1.0

uniprot Q5Z859 149
type: UnificationXref
id: Q5Z859
db: uniprot

Suppressor of cytokine signaling 5
type: ProteinReference
xref: uniprot O75159 222
xref: PTHR10155:SF15
organism: Homo sapiens