PANTHER Pathway P00036 1
type: UnificationXref
id: P00036
db: PANTHER Pathway

uniprot E1B8P9 65
type: UnificationXref
id: E1B8P9
db: uniprot

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot E2QVF3 66
xref: PTHR24055:SF171
organism: Canis lupus familiaris

Interleukin-6
type: ProteinReference
xref: uniprot P20607 173
organism: Rattus norvegicus

GSK3
type: Protein
entity reference: GSK3
feature: GSK3 s35 a50 rs1
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 2

Uncharacterized protein
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot A0A452DI16 328
organism: Bos taurus

PTHR24351:SF200
type: RelationshipXref
id: PTHR24351:SF200
db: PANTHER Family
relationship type: By Homology

ERK s93 a137 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Mitogen-activated protein kinase 6
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot Q16659 93
organism: Homo sapiens

uniprot H2Q104 286
type: UnificationXref
id: H2Q104
db: uniprot

uniprot P47873 179
type: UnificationXref
id: P47873
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 24

PARTICIPANT STOICHIOMETRY r36 646
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r36 647
type: Stoichiometry
physical entity: GSK3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r36 648
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Insulin receptor substrate 1
type: ProteinReference
xref: PTHR10614:SF11
xref: uniprot F1MYE0 291
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r36 649
type: Stoichiometry
physical entity: GSK3
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P28482 89
xref: PTHR24055:SF203
organism: Homo sapiens

p21CIP1
type: Protein
entity reference: p21CIP1
feature: p21CIP1 s59 a104 rs1
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Interleukin-21
type: ProteinReference
xref: uniprot Q9HBE4 191
xref: PTHR14356:SF2
organism: Homo sapiens

uniprot A5A6H2 118
type: UnificationXref
id: A5A6H2
db: uniprot

uniprot F7E823 75
type: UnificationXref
id: F7E823
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F1PXS7 69
organism: Canis lupus familiaris

uniprot K7CEN2 84
type: UnificationXref
id: K7CEN2
db: uniprot

Interleukin
type: Protein
entity reference: Interleukin
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa7 550
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot E2RE22 496
type: UnificationXref
id: E2RE22
db: uniprot

uniprot Q6P023 99
type: UnificationXref
id: Q6P023
db: uniprot

PTHR10573:SF0
type: RelationshipXref
id: PTHR10573:SF0
db: PANTHER Family
relationship type: By Homology

Interleukin-13 receptor subunit alpha-2
type: ProteinReference
xref: uniprot Q8VHK6 463
xref: PTHR23036:SF101
organism: Rattus norvegicus

Grb2
type: Protein
entity reference: Grb2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F1Q118 302
xref: PTHR23113:SF168
organism: Canis lupus familiaris

uniprot A0A2I3SXI2 257
type: UnificationXref
id: A0A2I3SXI2
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P27361 87
xref: PTHR24055:SF393
organism: Homo sapiens

uniprot E1BJP4 368
type: UnificationXref
id: E1BJP4
db: uniprot

uniprot Q9UHF4 469
type: UnificationXref
id: Q9UHF4
db: uniprot

uniprot F1M7N7 42
type: UnificationXref
id: F1M7N7
db: uniprot

Transcription factor Spi-C
type: ProteinReference
xref: PTHR11849:SF17
xref: uniprot Q8N5J4 385
organism: Homo sapiens

uniprot F6T2X3 502
type: UnificationXref
id: F6T2X3
db: uniprot

uniprot A0A0G2K5T3 387
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

p90RSK
type: Protein
entity reference: p90RSK
feature: p90RSK s84 a144 rs1
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

3-phosphoinositide dependent protein kinase 1
type: ProteinReference
xref: uniprot A0A2I3TN41 353
xref: PTHR24356:SF163
organism: Pan troglodytes

MAPKAPK2
type: ProteinReference
xref: P00979
standard name: Mitogen-activated protein kinase-activated protein kinase 2
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen-activated protein kinase-activated protein kinase 2 Synonym: MAPKAP kinase 2,MAPKAPK2 Accession: P00979
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.MAPKAPK2
member entity reference: MAP kinase-activated protein kinase 2
member entity reference: MAPKAPK2 isoform 1
member entity reference: Mitogen-activated protein kinase-activated protein kinase 2
member entity reference: Uncharacterized protein

NRAS protein
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot A5D7R9 270
organism: Bos taurus

uniprot F7ACT4 262
type: UnificationXref
id: F7ACT4
db: uniprot

uniprot E1BJR2 378
type: UnificationXref
id: E1BJR2
db: uniprot

uniprot H2QIK5 155
type: UnificationXref
id: H2QIK5
db: uniprot

PTHR24351:SF213
type: RelationshipXref
id: PTHR24351:SF213
db: PANTHER Family
relationship type: By Homology

Pro-interleukin-16
type: ProteinReference
xref: uniprot O54824 159
organism: Mus musculus

uniprot B8JIQ1 259
type: UnificationXref
id: B8JIQ1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR20859:SF21
xref: uniprot F7FMI1 421
organism: Macaca mulatta

uniprot Q04970 275
type: UnificationXref
id: Q04970
db: uniprot

MEK
type: Protein
entity reference: MEK
feature: MEK s23 a33 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: PTHR11139:SF9
xref: uniprot H9ENS2 112
organism: Macaca mulatta

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF213
xref: uniprot F7FRY0 49
organism: Monodelphis domestica

IL9 isoform 1
type: ProteinReference
xref: uniprot H2QRJ2 158
organism: Pan troglodytes

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A2I3TRE4 494
organism: Pan troglodytes

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot Q9Z1L0 406
organism: Rattus norvegicus

uniprot E1BFB4 108
type: UnificationXref
id: E1BFB4
db: uniprot

uniprot P01100 122
type: UnificationXref
id: P01100
db: uniprot

uniprot A0A2I3SE97 414
type: UnificationXref
id: A0A2I3SE97
db: uniprot

uniprot P01108 483
type: UnificationXref
id: P01108
db: uniprot

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot P09416 485
xref: PTHR45851:SF1
organism: Rattus norvegicus

uniprot Q6PHB0 462
type: UnificationXref
id: Q6PHB0
db: uniprot

uniprot Q99N57 345
type: UnificationXref
id: Q99N57
db: uniprot

PTHR10194:SF19
type: RelationshipXref
id: PTHR10194:SF19
db: PANTHER Family
relationship type: By Homology

uniprot A2VDT5 4
type: UnificationXref
id: A2VDT5
db: uniprot

Myc proto-oncogene protein
type: ProteinReference
xref: PTHR45851:SF1
xref: uniprot P23583 486
organism: Pan troglodytes

CDKN1B protein
type: ProteinReference
xref: uniprot A6QLS3 314
xref: PTHR10265:SF9
organism: Bos taurus

Interleukin-10 receptor subunit alpha
type: ProteinReference
xref: PTHR20859:SF43
xref: uniprot Q61727 459
organism: Mus musculus

STATE_TRANSITION_LEFT__PDK1_2-_ATP-RIGHT__PDK1_2-_ADP-_r34
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 660
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 658
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 659
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 661
left: PDK1/2
left: ATP
interaction type: STATE_TRANSITION
right: PDK1/2
right: ADP

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot P41969 25
organism: Mus musculus

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: PTHR24349:SF114
xref: uniprot Q4G050 198
organism: Rattus norvegicus

uniprot Q8N5J4 385
type: UnificationXref
id: Q8N5J4
db: uniprot

PTHR10078:SF33
type: RelationshipXref
id: PTHR10078:SF33
db: PANTHER Family
relationship type: By Homology

uniprot P41158 23
type: UnificationXref
id: P41158
db: uniprot

uniprot Q63844 98
type: UnificationXref
id: Q63844
db: uniprot

uniprot Q68SP3 529
type: UnificationXref
id: Q68SP3
db: uniprot

uniprot Q00560 143
type: UnificationXref
id: Q00560
db: uniprot

ETS domain-containing protein Elk-3
type: ProteinReference
xref: uniprot P41971 28
organism: Mus musculus

ETS domain-containing protein Elk-3
type: ProteinReference
xref: uniprot P41970 27
organism: Homo sapiens

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F7H7W3 50
xref: PTHR24351:SF43
organism: Macaca mulatta

uniprot Q13261 450
type: UnificationXref
id: Q13261
db: uniprot

NRAS proto-oncogene, GTPase
type: ProteinReference
xref: uniprot F1PHV7 271
xref: PTHR24070:SF189
organism: Canis lupus familiaris

uniprot F6SW23 391
type: UnificationXref
id: F6SW23
db: uniprot

Inhibitor of nuclear factor kappa B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot E2RKR0 126
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ras-_GTP-RIGHT__GDP-_Ras-_r6
controller: Complex (Grb2/Shc/ SOS)

ETS domain-containing protein Elk-3
type: ProteinReference
xref: uniprot F7F772 16
organism: Macaca mulatta

Interleukin-1
type: ProteinReference
xref: uniprot H2QIK5 155
xref: PTHR10078:SF33
organism: Pan troglodytes

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F6T2X3 502
xref: PTHR11801:SF39
organism: Xenopus tropicalis

NRAS isoform 1
type: ProteinReference
xref: uniprot H2PZQ7 272
xref: PTHR24070:SF189
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E7EXT6 211
xref: PTHR24356:SF190
organism: Danio rerio

uniprot O08605 197
type: UnificationXref
id: O08605
db: uniprot

PI3K
type: Protein
entity reference: PI3K
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7DUD6 394
xref: PTHR10048:SF107
organism: Ornithorhynchus anatinus

Evidence 205
type: Evidence
evidence code: TAS
comment: SPACC Q9BUB5

uniprot E7EXT6 211
type: UnificationXref
id: E7EXT6
db: uniprot

Evidence 204
type: Evidence
evidence code: IC
comment: SPACC Q9BUB5

uniprot K7AI61 236
type: UnificationXref
id: K7AI61
db: uniprot

uniprot F1N4K5 475
type: UnificationXref
id: F1N4K5
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6QP11 216
organism: Monodelphis domestica

A-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot E2RL20 330
xref: PTHR44329:SF55
organism: Canis lupus familiaris

MAP kinase-interacting serine/threonine-protein kinase 2
type: ProteinReference
xref: PTHR24349:SF254
xref: uniprot Q9HBH9 206
organism: Homo sapiens

uniprot P41324 178
type: UnificationXref
id: P41324
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q63844 98
organism: Mus musculus

p27KIP1
type: Protein
entity reference: p27KIP1
feature: p27KIP1 s71 a111 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F7BYN4 505
type: UnificationXref
id: F7BYN4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r7
controller: Ras

Si:dkeyp-80c12.7
type: ProteinReference
xref: uniprot B8JIQ1 259
xref: PTHR24057:SF8
organism: Danio rerio

uniprot E2RB82 495
type: UnificationXref
id: E2RB82
db: uniprot

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: uniprot G3V926 130
xref: PTHR22969:SF13
organism: Rattus norvegicus

TRANSPORT_LEFT__STAT-RIGHT__STAT-_r67
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 651
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 650
left: STAT
interaction type: TRANSPORT
right: STAT

Receptor subunit beta
type: Protein
entity reference: Receptor subunit beta
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa5 546
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A0A3Q1LSD1 360
type: UnificationXref
id: A0A3Q1LSD1
db: uniprot

uniprot Q8BTI9 405
type: UnificationXref
id: Q8BTI9
db: uniprot

ATP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r45 595
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot P14056 341
type: UnificationXref
id: P14056
db: uniprot

PARTICIPANT STOICHIOMETRY r45 598
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 597
type: Stoichiometry
physical entity: p27KIP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 596
type: Stoichiometry
physical entity: p27KIP1
stoichiometric coefficient: 1.0

Grb2
type: ProteinReference
xref: P00971
standard name: Growth factor receptor-bound protein 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Growth Factor Receptor Binding Protein 2 Synonym: Abundant SRC homology (ASH),Grb2 Accession: P00971
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.Grb2
member entity reference: Growth factor receptor-bound protein 2a

ATP
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F7BWW9 306
organism: Ornithorhynchus anatinus

PTHR46037:SF4
type: RelationshipXref
id: PTHR46037:SF4
db: PANTHER Family
relationship type: By Homology

PTHR23036:SF51
type: RelationshipXref
id: PTHR23036:SF51
db: PANTHER Family
relationship type: By Homology

uniprot E2QZ78 417
type: UnificationXref
id: E2QZ78
db: uniprot

uniprot P79255 186
type: UnificationXref
id: P79255
db: uniprot

GO GO:0005737 3
type: UnificationXref
id: GO:0005737
db: GO

00696
type: UnificationXref
id: MOD:00696
db: mod

uniprot F1MGJ4 497
type: UnificationXref
id: F1MGJ4
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot H2RA86 83
organism: Pan troglodytes

Serum response factor
type: ProteinReference
xref: uniprot Q9JM73 374
xref: PTHR48019:SF40
organism: Mus musculus

uniprot A0A1D5NWT4 32
type: UnificationXref
id: A0A1D5NWT4
db: uniprot

eNOS
type: ProteinReference
xref: P00986
standard name: endothelial nitric oxide synthase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.eNOS
comment: ENTITY_REFERENCE_NOTES=Long Name: endothelial nitric oxide synthase Synonym: eNOS Accession: P00986
member entity reference: Nitric oxide synthase
member entity reference: Nitric oxide synthase, endothelial

uniprot F7EI48 78
type: UnificationXref
id: F7EI48
db: uniprot

uniprot H9ENS2 112
type: UnificationXref
id: H9ENS2
db: uniprot

PTHR10489:SF916
type: RelationshipXref
id: PTHR10489:SF916
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_mTOR-RIGHT__ADP-_mTOR-_r43
controller: PKB

PTHR23036:SF83
type: RelationshipXref
id: PTHR23036:SF83
db: PANTHER Family
relationship type: By Homology

Interleukin-4
type: ProteinReference
xref: uniprot P30367 176
xref: PTHR47401:SF1
organism: Bos taurus

p90RSK s94 a152 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Interleukin 12 receptor subunit beta 1
type: ProteinReference
xref: PTHR23036:SF51
xref: uniprot H2R3T4 235
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G4D2 371
xref: PTHR48019:SF40
organism: Macaca mulatta

uniprot H2QRJ2 158
type: UnificationXref
id: H2QRJ2
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A3Q2UBK0 39
xref: PTHR24351:SF213
organism: Gallus gallus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: SRF

PTHR23036:SF79
type: RelationshipXref
id: PTHR23036:SF79
db: PANTHER Family
relationship type: By Homology

uniprot F7BRK5 331
type: UnificationXref
id: F7BRK5
db: uniprot

TRANSPORT_LEFT__MAPKAPK2-RIGHT__MAPKAPK2-_r57
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 671
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 670
left: MAPKAPK2
interaction type: TRANSPORT
right: MAPKAPK2

uniprot Q9NPF7 468
type: UnificationXref
id: Q9NPF7
db: uniprot

PTHR44329:SF55
type: RelationshipXref
id: PTHR44329:SF55
db: PANTHER Family
relationship type: By Homology

IL10RB isoform 1
type: ProteinReference
xref: uniprot K7AI61 236
organism: Pan troglodytes

STATE_TRANSITION_LEFT__MNK1_2-_ATP-RIGHT__ADP-_MNK1_2-_r51
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 692
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 693
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 691
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 690
left: MNK1/2
left: ATP
interaction type: STATE_TRANSITION
right: MNK1/2
right: ADP

uniprot P23583 486
type: UnificationXref
id: P23583
db: uniprot

c Myc s86 a138 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F7CHH2 506
type: UnificationXref
id: F7CHH2
db: uniprot

ADP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR44329:SF47
type: RelationshipXref
id: PTHR44329:SF47
db: PANTHER Family
relationship type: By Homology

ERK
type: Protein
entity reference: ERK
feature: ERK s27 a36 rs1
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P52633 526
type: UnificationXref
id: P52633
db: uniprot

PTHR20859:SF50
type: RelationshipXref
id: PTHR20859:SF50
db: PANTHER Family
relationship type: By Homology

Glycogen synthase kinase 3
type: ProteinReference
xref: uniprot Q9YH60 267
xref: PTHR24057:SF8
organism: Danio rerio

uniprot Q9W6U9 144
type: UnificationXref
id: Q9W6U9
db: uniprot

uniprot Q14627 453
type: UnificationXref
id: Q14627
db: uniprot

PARTICIPANT STOICHIOMETRY r67 650
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r67 651
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

MEK
type: Protein
entity reference: MEK
feature: MEK s26 a35 rs1
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A5D7R9 270
type: UnificationXref
id: A5D7R9
db: uniprot

uniprot Q60837 247
type: UnificationXref
id: Q60837
db: uniprot

PTHR23036:SF98
type: RelationshipXref
id: PTHR23036:SF98
db: PANTHER Family
relationship type: By Homology

Jak s104 a12 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.04
comment: MODIFICATION_RESIDUE_NAME=

Growth factor receptor-bound protein 2a
type: ProteinReference
xref: PTHR46037:SF4
xref: uniprot Q5RKN6 192
organism: Danio rerio

PTHR22969:SF7
type: RelationshipXref
id: PTHR22969:SF7
db: PANTHER Family
relationship type: By Homology

Inhibitor of nuclear factor kappa B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot H2QW34 131
organism: Pan troglodytes

Interleukin-6
type: ProteinReference
xref: uniprot F1PXV9 152
organism: Canis lupus familiaris

uniprot F1MEB5 231
type: UnificationXref
id: F1MEB5
db: uniprot

PTHR20859:SF43
type: RelationshipXref
id: PTHR20859:SF43
db: PANTHER Family
relationship type: By Homology

PTHR10155:SF6
type: RelationshipXref
id: PTHR10155:SF6
db: PANTHER Family
relationship type: By Homology

uniprot P42232 521
type: UnificationXref
id: P42232
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot A0A3Q2U4X3 209
organism: Gallus gallus

Serum response factor
type: ProteinReference
xref: uniprot E1BJP4 368
xref: PTHR48019:SF40
organism: Bos taurus

uniprot Q99665 249
type: UnificationXref
id: Q99665
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RPJ2 68
xref: PTHR24055:SF356
organism: Canis lupus familiaris

Interleukin-11
type: ProteinReference
xref: uniprot P47873 179
organism: Mus musculus

PTHR23036:SF89
type: RelationshipXref
id: PTHR23036:SF89
db: PANTHER Family
relationship type: By Homology

c fos s96 a166 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

eco ECO:0000316 53
type: UnificationXref
id: ECO:0000316
db: eco

uniprot K7B4P2 113
type: UnificationXref
id: K7B4P2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Ets-RIGHT__Ets-_ADP-_r55
controller: ERK

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot A0A140T878 488
organism: Bos taurus

PTHR44329:SF22
type: RelationshipXref
id: PTHR44329:SF22
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_BAD-RIGHT__ADP-_BAD-_r38
controller: PKB

uniprot E2QVF3 66
type: UnificationXref
id: E2QVF3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HPR8 537
xref: PTHR10337:SF2
organism: Macaca mulatta

Raf s22 a30 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

IRS1 2 s129 a58 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot G3V6S7 423
type: UnificationXref
id: G3V6S7
db: uniprot

uniprot A5PKJ4 64
type: UnificationXref
id: A5PKJ4
db: uniprot

Mitogen-activated protein kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot F6PX17 284
organism: Ornithorhynchus anatinus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot A0A0G2K5T3 387
xref: PTHR10048:SF107
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR11849:SF16
xref: uniprot A0A1D5P5I9 375
organism: Gallus gallus

Raf s22 a32 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Spi-1 proto-oncogene
type: ProteinReference
xref: uniprot E1BJR2 378
xref: PTHR11849:SF16
organism: Bos taurus

PTHR20859:SF21
type: RelationshipXref
id: PTHR20859:SF21
db: PANTHER Family
relationship type: By Homology

uniprot F6RCU6 218
type: UnificationXref
id: F6RCU6
db: uniprot

uniprot Q07889 311
type: UnificationXref
id: Q07889
db: uniprot

STAT s115 a175 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

Nitric oxide synthase, endothelial
type: ProteinReference
xref: uniprot P70313 364
xref: PTHR19384:SF66
organism: Mus musculus

PKB
type: Protein
entity reference: PKB
feature: PKB s12 a18 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F7EI48 78
organism: Monodelphis domestica

Gene transcription
type: Pathway

uniprot Q6BDS1 383
type: UnificationXref
id: Q6BDS1
db: uniprot

uniprot P27704 88
type: UnificationXref
id: P27704
db: uniprot

Transcription factor Spi-C
type: ProteinReference
xref: uniprot Q6P3D7 384
xref: PTHR11849:SF17
organism: Mus musculus

ncbitaxon 10116 7
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot A0A2I3TNY5 492
type: UnificationXref
id: A0A2I3TNY5
db: uniprot

PTHR10179:SF42
type: RelationshipXref
id: PTHR10179:SF42
db: PANTHER Family
relationship type: By Homology

Interleukin-15 receptor subunit alpha
type: ProteinReference
xref: uniprot Q13261 450
organism: Homo sapiens

uniprot P70225 447
type: UnificationXref
id: P70225
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F7GEK1 220
organism: Monodelphis domestica

BAD
type: Protein
feature: BAD s61 a99 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MEK s23 a33 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ncbitaxon 9913 5
type: UnificationXref
id: 9913
db: ncbitaxon

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: uniprot Q9JLN9 116
xref: PTHR11139:SF9
organism: Mus musculus

SOS
type: Protein
entity reference: SOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa3 556
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot Q9V3Q6 352
organism: Drosophila melanogaster

C-X-C chemokine receptor type 1
type: ProteinReference
xref: PTHR10489:SF916
xref: uniprot Q2YEG0 454
organism: Macaca mulatta

uniprot F7G8G5 509
type: UnificationXref
id: F7G8G5
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

BAD s54 a98 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SRF
type: Protein
entity reference: SRF
feature: SRF s101 a169 rs1
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r56 672
type: Stoichiometry
physical entity: p90RSK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r56 673
type: Stoichiometry
physical entity: p90RSK
stoichiometric coefficient: 1.0

uniprot F1PPR5 151
type: UnificationXref
id: F1PPR5
db: uniprot

Signal transducer and activator of transcription 5B
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot P51692 522
organism: Homo sapiens

ncbitaxon 9258 46
type: UnificationXref
id: 9258
db: ncbitaxon

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: PTHR24349:SF114
xref: uniprot O08605 197
organism: Mus musculus

IL6ST isoform 1
type: ProteinReference
xref: PTHR23036:SF83
xref: uniprot A0A2I3RK51 139
organism: Pan troglodytes

uniprot Q04982 344
type: UnificationXref
id: Q04982
db: uniprot

STAT s116 a176 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

uniprot W4Y0P1 268
type: UnificationXref
id: W4Y0P1
db: uniprot

uniprot H2QH62 154
type: UnificationXref
id: H2QH62
db: uniprot

PARTICIPANT STOICHIOMETRY r55 674
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r55 675
type: Stoichiometry
physical entity: Ets
stoichiometric coefficient: 1.0

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 8

PARTICIPANT STOICHIOMETRY r55 676
type: Stoichiometry
physical entity: Ets
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r55 677
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Src like s47 a67 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Interleukin-15
type: ProteinReference
xref: uniprot P40933 177
xref: PTHR14356:SF3
organism: Homo sapiens

Interleukin-12 receptor subunit beta-1
type: ProteinReference
xref: uniprot P42701 242
xref: PTHR23036:SF51
organism: Homo sapiens

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot O14920 132
organism: Homo sapiens

Shc
type: Protein
entity reference: Shc
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa2 554
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Evidence 195
type: Evidence
evidence code: ISS
comment: SPACC Q9BUB5

uniprot P52632 525
type: UnificationXref
id: P52632
db: uniprot

p21CIP1
type: Protein
entity reference: p21CIP1
feature: p21CIP1 s120 a110 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 48

PARTICIPANT STOICHIOMETRY r18 571
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

ELK3, ETS transcription factor
type: ProteinReference
xref: uniprot D4A9V6 11
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r18 573
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR20859:SF43
xref: uniprot F7AR90 420
organism: Macaca mulatta

FKHRL1
type: Protein
entity reference: FKHRL1
feature: FKHRL1 s56 a101 rs1
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r18 572
type: Stoichiometry
physical entity: Src-like
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r18 574
type: Stoichiometry
physical entity: Src-like
stoichiometric coefficient: 1.0

eco ECO:0000304 107
type: UnificationXref
id: ECO:0000304
db: eco

uniprot K7D3K8 511
type: UnificationXref
id: K7D3K8
db: uniprot

Ribosomal protein S6 kinase alpha-6
type: ProteinReference
xref: uniprot Q9UK32 58
xref: PTHR24351:SF98
organism: Homo sapiens

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot O15530 355
organism: Homo sapiens

IEP
type: EvidenceCodeVocabulary
xref: eco ECO:0000270 424

MEK
type: ProteinReference
xref: P00984
standard name: Mitogen-activated protein kinase kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.MEK
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen activated protein kinase kinase kinase Synonym: MAP kinase kinase kinase,MAPKKK,MEK kinase,MEKK Accession: P00984
member entity reference: Mitogen-activated protein kinase kinase kinase 4
member entity reference: Mitogen-activated protein kinase kinase kinase 7
member entity reference: Uncharacterized protein

c-Myc
type: Protein
entity reference: c-Myc
feature: c Myc s86 a138 rs1
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q2HJ27 487
type: UnificationXref
id: Q2HJ27
db: uniprot

Interleukin-6
type: ProteinReference
xref: uniprot P26892 175
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F7G3I5 397
organism: Monodelphis domestica

uniprot E2QYK5 119
type: UnificationXref
id: E2QYK5
db: uniprot

uniprot F6PGQ1 261
type: UnificationXref
id: F6PGQ1
db: uniprot

SHC (Src homology 2 domain containing) transforming protein 1
type: ProteinReference
xref: uniprot H2R8L2 538
xref: PTHR10337:SF2
organism: Pan troglodytes

IL20RA isoform 2
type: ProteinReference
xref: PTHR20859:SF21
xref: uniprot A0A2I3RAL0 412
organism: Pan troglodytes

STATE_TRANSITION_LEFT__PKB-RIGHT__Pi-_PKB-_r48
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 586
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 587
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 585
left: PKB
interaction type: STATE_TRANSITION
right: Pi
right: PKB

Jak
type: ProteinReference
xref: P00978
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.Jak
comment: ENTITY_REFERENCE_NOTES=Long Name: Jak Synonym: Synonym not specified Accession: P00978
member entity reference: Tyrosine-protein kinase JAK3
member entity reference: Tyrosine-protein kinase

RasGAP
type: ProteinReference
xref: P00975
standard name: Ras GTPase-Activating Protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Ras GTPase Activity Protein Synonym: RasGAP Accession: P00975
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.RasGAP
member entity reference: Ras GTPase-activating protein 1
member entity reference: RAS p21 protein activator 1
member entity reference: RAS p21 protein activator (GTPase activating protein) 1
member entity reference: Uncharacterized protein

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6WBW6 73
xref: PTHR24055:SF356
organism: Macaca mulatta

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot A0A3Q1M353 327
xref: PTHR44329:SF47
organism: Bos taurus

uniprot Q6P3D7 384
type: UnificationXref
id: Q6P3D7
db: uniprot

c-Myc
type: ProteinReference
xref: P00995
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.c-Myc
comment: ENTITY_REFERENCE_NOTES=Long Name: c-Myc Synonym: Synonym not specified Accession: P00995
member entity reference: Myc proto-oncogene protein

Uncharacterized protein (Fragment)
type: ProteinReference
xref: uniprot M0R3H8 380
xref: PTHR11849:SF174
organism: Homo sapiens

uniprot P63085 90
type: UnificationXref
id: P63085
db: uniprot

Ikk
type: ProteinReference
xref: P00968
standard name: Inhibitor of kappa-B kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Inhibitor of kappa-B kinase Synonym: IKK Accession: P00968
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.Ikk
member entity reference: Inhibitor of nuclear factor kappa B kinase subunit beta
member entity reference: Inhibitor of nuclear factor kappa-B kinase subunit alpha
member entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta
member entity reference: Uncharacterized protein
member entity reference: Conserved helix-loop-helix ubiquitous kinase

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot O08648 351
organism: Mus musculus

uniprot Q9HBE4 191
type: UnificationXref
id: Q9HBE4
db: uniprot

Interleukin-10 receptor subunit alpha
type: ProteinReference
xref: PTHR20859:SF43
xref: uniprot Q13651 451
organism: Homo sapiens

Receptor subunit alpha
type: Protein
entity reference: Receptor subunit alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa4 544
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Interleukin-5 receptor subunit alpha
type: ProteinReference
xref: PTHR23036:SF17
xref: uniprot A0A1D5Q7M2 410
organism: Macaca mulatta

uniprot A0A2I3TK00 326
type: UnificationXref
id: A0A2I3TK00
db: uniprot

uniprot P08831 167
type: UnificationXref
id: P08831
db: uniprot

uniprot F7C2C6 74
type: UnificationXref
id: F7C2C6
db: uniprot

ACTIVE 31
type: EntityFeature
comment: Active state

uniprot P98083 540
type: UnificationXref
id: P98083
db: uniprot

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 324
evidence: Evidence 322
evidence: Evidence 323
evidence: Evidence 321
xref: PTHR44329:SF22
xref: uniprot A0A2I3THL4 325
organism: Pan troglodytes

uniprot A0A1D5P5I9 375
type: UnificationXref
id: A0A1D5P5I9
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot A0A3Q1NH21 208
organism: Bos taurus

uniprot F1MX38 498
type: UnificationXref
id: F1MX38
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7GAP5 398
organism: Ornithorhynchus anatinus

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P21708 86
xref: PTHR24055:SF393
organism: Rattus norvegicus

uniprot C0KXH8 377
type: UnificationXref
id: C0KXH8
db: uniprot

GO GO:0005634 2
type: UnificationXref
id: GO:0005634
db: GO

uniprot F6V2V1 45
type: UnificationXref
id: F6V2V1
db: uniprot

uniprot F1PNW8 500
type: UnificationXref
id: F1PNW8
db: uniprot

uniprot H2Q687 428
type: UnificationXref
id: H2Q687
db: uniprot

p27KIP1
type: Protein
entity reference: p27KIP1
feature: p27KIP1 s60 a105 rs1
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q1KQ07 528
type: UnificationXref
id: Q1KQ07
db: uniprot

uniprot P40190 142
type: UnificationXref
id: P40190
db: uniprot

C-X-C chemokine receptor type 2 (Fragment)
type: ProteinReference
xref: uniprot Q28519 245
xref: PTHR10489:SF689
organism: Macaca mulatta

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2RP04 41
xref: PTHR24351:SF58
organism: Canis lupus familiaris

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot F6SHC1 128
organism: Macaca mulatta

uniprot F6WX28 120
type: UnificationXref
id: F6WX28
db: uniprot

p21CIP1
type: ProteinReference
xref: P00993
standard name: Cyclin-dependent kinase inhibitor 1A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Cyclin-dependent kinase inhibitor 1A Synonym: CDKN1A,p21,p21CIP1,p21WAF1 Accession: P00993
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.p21CIP1
member entity reference: Cyclin-dependent kinase inhibitor 1
member entity reference: Cyclin-dependent kinase inhibitor 1A

Danio rerio
type: BioSource
xref: ncbitaxon 7955 100

uniprot F7GSZ4 233
type: UnificationXref
id: F7GSZ4
db: uniprot

Nitric oxide synthase, endothelial
type: ProteinReference
xref: uniprot Q9TUX8 366
xref: PTHR19384:SF66
organism: Canis lupus familiaris

Interleukin-6 receptor subunit beta
type: ProteinReference
xref: PTHR23036:SF83
xref: uniprot Q00560 143
organism: Mus musculus

uniprot Q14765 527
type: UnificationXref
id: Q14765
db: uniprot

PARTICIPANT STOICHIOMETRY r48 587
type: Stoichiometry
physical entity: PKB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r48 586
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

uniprot P97378 243
type: UnificationXref
id: P97378
db: uniprot

PTHR10265:SF9
type: RelationshipXref
id: PTHR10265:SF9
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR23036:SF89
xref: uniprot G3X7E9 426
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r48 585
type: Stoichiometry
physical entity: PKB
stoichiometric coefficient: 1.0

uniprot Q5RKN6 192
type: UnificationXref
id: Q5RKN6
db: uniprot

uniprot F7EH19 76
type: UnificationXref
id: F7EH19
db: uniprot

uniprot F1MYJ4 212
type: UnificationXref
id: F1MYJ4
db: uniprot

Transcription factor PU.1
type: ProteinReference
xref: PTHR11849:SF16
xref: uniprot P17947 382
organism: Homo sapiens

uniprot H2PZQ7 272
type: UnificationXref
id: H2PZQ7
db: uniprot

Interleukin-2 receptor subunit beta
type: ProteinReference
xref: PTHR23037:SF30
xref: uniprot P14784 237
organism: Homo sapiens

uniprot O55173 356
type: UnificationXref
id: O55173
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23036:SF79
xref: uniprot F6X0C8 232
organism: Macaca mulatta

uniprot P48092 181
type: UnificationXref
id: P48092
db: uniprot

uniprot O43524 478
type: UnificationXref
id: O43524
db: uniprot

Serum response factor
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot D3ZHH8 367
organism: Rattus norvegicus

uniprot G3X7B5 221
type: UnificationXref
id: G3X7B5
db: uniprot

uniprot F7BWW9 306
type: UnificationXref
id: F7BWW9
db: uniprot

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot P15056 342
organism: Homo sapiens

uniprot B8XIA5 480
type: UnificationXref
id: B8XIA5
db: uniprot

uniprot Q95KV0 136
type: UnificationXref
id: Q95KV0
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6XP81 219
organism: Xenopus tropicalis

MAP kinase-interacting serine/threonine-protein kinase 2
type: ProteinReference
xref: uniprot Q5U2N4 200
xref: PTHR24349:SF254
organism: Rattus norvegicus

uniprot Q9UK32 58
type: UnificationXref
id: Q9UK32
db: uniprot

Ikk s64 a109 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A0A140TAX8 146
type: UnificationXref
id: A0A140TAX8
db: uniprot

Transcription factor PU.1
type: ProteinReference
xref: uniprot Q6BDS1 383
xref: PTHR11849:SF16
organism: Rattus norvegicus

uniprot F6TJU6 194
type: UnificationXref
id: F6TJU6
db: uniprot

uniprot Q8VHK6 463
type: UnificationXref
id: Q8VHK6
db: uniprot

uniprot O77762 160
type: UnificationXref
id: O77762
db: uniprot

PARTICIPANT STOICHIOMETRY r69 639
type: Stoichiometry
physical entity: Interleukin
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot F7G8G5 509
organism: Macaca mulatta

uniprot F7HHY8 285
type: UnificationXref
id: F7HHY8
db: uniprot

Ras
type: Protein
entity reference: Ras
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5QL06 33
type: UnificationXref
id: A0A1D5QL06
db: uniprot

PDK1/2
type: ProteinReference
xref: P00985
standard name: 3-phosphoinositide-dependent protein kinase 1 and 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.PDK1/2
comment: ENTITY_REFERENCE_NOTES=Long Name: 3'-Phosphoinositide-dependent protein kinase1/2 Synonym: PDK1,PDPK1 Accession: P00985
member entity reference: 3-phosphoinositide-dependent protein kinase 1
member entity reference: Uncharacterized protein
member entity reference: 3-phosphoinositide dependent protein kinase 1

STAT s8 a14 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.870260612568485
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

STATE_TRANSITION_LEFT__ATP-_eNOS-RIGHT__ADP-_eNOS-_r41
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 621
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 622
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 620
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 619
left: ATP
left: eNOS
interaction type: STATE_TRANSITION
right: ADP
right: eNOS

PARTICIPANT STOICHIOMETRY r69 638
type: Stoichiometry
physical entity: Receptor subunit beta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r69 637
type: Stoichiometry
physical entity: Receptor subunit alpha
stoichiometric coefficient: 1.0

uniprot F1NZN5 150
type: UnificationXref
id: F1NZN5
db: uniprot

uniprot P42338 404
type: UnificationXref
id: P42338
db: uniprot

Raf
type: ProteinReference
xref: P00983
standard name: Raf Oncogene
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Raf Synonym: Synonym not specified Accession: P00983
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.Raf
member entity reference: Raf-1 proto-oncogene, serine/threonine kinase
member entity reference: RAF proto-oncogene serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase A-Raf
member entity reference: B-Raf proto-oncogene, serine/threonine kinase
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase B-raf
member entity reference: A-Raf proto-oncogene, serine/threonine kinase

ELK
type: Protein
entity reference: ELK
feature: ELK s30 a43 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P27361 87
type: UnificationXref
id: P27361
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_Pi-_r14
controller: RasGAP

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot F6YJ34 47
organism: Monodelphis domestica

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 7

p90RSK
type: Protein
entity reference: p90RSK
feature: p90RSK s94 a152 rs1
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

uniprot H2QPN2 156
type: UnificationXref
id: H2QPN2
db: uniprot

uniprot Q9TUX8 366
type: UnificationXref
id: Q9TUX8
db: uniprot

mTOR
type: ProteinReference
xref: P00966
standard name: mammalian target of rapamycin
comment: ENTITY_REFERENCE_NOTES=Long Name: mammalian target of rapamycin Synonym: mTOR Accession: P00966
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.mTOR
member entity reference: Serine/threonine-protein kinase TOR
member entity reference: Serine/threonine-protein kinase mTOR

uniprot H2R3T4 235
type: UnificationXref
id: H2R3T4
db: uniprot

PARTICIPANT STOICHIOMETRY r69 640
type: Stoichiometry
physical entity: Signaling subunit
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r69 641
type: Stoichiometry
physical entity: Complex (Receptor subunit alpha/Receptor subunit beta/ Signaling subunit/Interleukin)
stoichiometric coefficient: 1.0

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot D3Z8E0 40
xref: PTHR24351:SF58
organism: Rattus norvegicus

uniprot P51494 184
type: UnificationXref
id: P51494
db: uniprot

uniprot P51692 522
type: UnificationXref
id: P51692
db: uniprot

uniprot O15111 133
type: UnificationXref
id: O15111
db: uniprot

uniprot P28482 89
type: UnificationXref
id: P28482
db: uniprot

PTHR10048:SF33
type: RelationshipXref
id: PTHR10048:SF33
db: PANTHER Family
relationship type: By Homology

uniprot P49137 287
type: UnificationXref
id: P49137
db: uniprot

MNK1 2 s81 a148 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P78552 448
type: UnificationXref
id: P78552
db: uniprot

uniprot A0A1D5QUZ8 63
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: uniprot O15111 133
xref: PTHR22969:SF13
organism: Homo sapiens

ELK3, ETS-domain protein (SRF accessory protein 2)
type: ProteinReference
xref: uniprot A2VDT5 4
organism: Bos taurus

uniprot Q9H6Q3 409
type: UnificationXref
id: Q9H6Q3
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot G3X7B5 221
xref: PTHR24351:SF200
organism: Bos taurus

PTHR24349:SF254
type: RelationshipXref
id: PTHR24349:SF254
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r54 678
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

STAT s8 a14 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r54 679
type: Stoichiometry
physical entity: c-Myc
stoichiometric coefficient: 1.0

FKHRL1
type: Protein
entity reference: FKHRL1
feature: FKHRL1 s63 a107 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F6R1P6 501
type: UnificationXref
id: F6R1P6
db: uniprot

PARTICIPANT STOICHIOMETRY r54 681
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r54 680
type: Stoichiometry
physical entity: c-Myc
stoichiometric coefficient: 1.0

uniprot P08887 438
type: UnificationXref
id: P08887
db: uniprot

ELK3, ETS transcription factor
type: ProteinReference
xref: uniprot E2QVW3 12
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r16 581
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r16 582
type: Stoichiometry
physical entity: IRS1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r16 583
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r16 584
type: Stoichiometry
physical entity: IRS1/2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ATP-_BAD-RIGHT__ADP-_BAD-_r38
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 634
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 635
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 636
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 633
left: ATP
left: BAD
interaction type: STATE_TRANSITION
right: ADP
right: BAD

uniprot P48089 180
type: UnificationXref
id: P48089
db: uniprot

uniprot M0R3H8 380
type: UnificationXref
id: M0R3H8
db: uniprot

Src like s131 a68 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r39 631
type: Stoichiometry
physical entity: PKB
stoichiometric coefficient: 1.0

IRS1/2
type: Protein
entity reference: IRS1/2
feature: IRS1 2 s129 a58 rs1
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

cytoplasm
type: CellularLocationVocabulary
xref: GO GO:0005737 3

uniprot A0A3Q2U4X3 209
type: UnificationXref
id: A0A3Q2U4X3
db: uniprot

Src-like
type: Protein
entity reference: Src-like
feature: Src like s131 a68 rs1
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

IL2RA protein
type: ProteinReference
xref: PTHR10573:SF0
xref: uniprot A2VE30 416
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Jak-RIGHT__Jak-_ADP-_r72
controller: Jak

PTHR10614:SF11
type: RelationshipXref
id: PTHR10614:SF11
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__ATP-_c_Myc-RIGHT__c_Myc-_ADP-_r54
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 681
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 679
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 680
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 678
left: c-Myc
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: c-Myc

uniprot P05625 337
type: UnificationXref
id: P05625
db: uniprot

PARTICIPANT STOICHIOMETRY r39 632
type: Stoichiometry
physical entity: PKB
stoichiometric coefficient: 1.0

uniprot K7D2P2 372
type: UnificationXref
id: K7D2P2
db: uniprot

PARTICIPANT STOICHIOMETRY r66 656
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r66 657
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

BAD
type: Protein
feature: BAD s54 a98 rs1
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_IRS1_2-RIGHT__ADP-_IRS1_2-_r16
controller: Complex (Receptor subunit alpha/Receptor subunit beta/ Signaling subunit/Interleukin)

PARTICIPANT STOICHIOMETRY r32 664
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r32 665
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

SRF
type: ProteinReference
xref: P00987
standard name: Serum response factor
comment: ENTITY_REFERENCE_NOTES=Long Name: Serum response factor Synonym: SRF Accession: P00987
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.SRF
member entity reference: Uncharacterized protein
member entity reference: SRF isoform 1
member entity reference: Serum response factor

ncbitaxon 13616 48
type: UnificationXref
id: 13616
db: ncbitaxon

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF3
xref: uniprot E1BEL4 278
organism: Bos taurus

uniprot P42227 517
type: UnificationXref
id: P42227
db: uniprot

uniprot P17947 382
type: UnificationXref
id: P17947
db: uniprot

uniprot F7BQ11 504
type: UnificationXref
id: F7BQ11
db: uniprot

uniprot A0A2I3SCX4 413
type: UnificationXref
id: A0A2I3SCX4
db: uniprot

eNOS s62 a106 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6RCU6 218
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F6X927 129
xref: PTHR22969:SF13
organism: Macaca mulatta

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: uniprot P42346 115
xref: PTHR11139:SF9
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 570
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 569
left: Raf
interaction type: STATE_TRANSITION
right: Raf

uniprot F7GEK1 220
type: UnificationXref
id: F7GEK1
db: uniprot

uniprot Q62137 280
type: UnificationXref
id: Q62137
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_MEK-RIGHT__MEK-_ADP-_r8
controller: Raf

uniprot F1PXS7 69
type: UnificationXref
id: F1PXS7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot F6WX28 120
organism: Monodelphis domestica

Interleukin-2 receptor subunit alpha (Fragment)
type: ProteinReference
xref: uniprot Q38IC8 455
organism: Pan troglodytes

STATE_TRANSITION_LEFT__ATP-_p21CIP1-RIGHT__ADP-_p21CIP1-_r44
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 603
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 606
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 604
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 605
left: p21CIP1
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: p21CIP1

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42336 402
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot P42338 404
organism: Homo sapiens

Cyclin-dependent kinase inhibitor 1B
type: ProteinReference
xref: uniprot P46414 318
organism: Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42337 403
organism: Mus musculus

STATE_TRANSITION_LEFT__ATP-_Ets-RIGHT__Ets-_ADP-_r55
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 676
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 675
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 674
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 677
left: ATP
left: Ets
interaction type: STATE_TRANSITION
right: ADP
right: Ets

uniprot F6URW3 304
type: UnificationXref
id: F6URW3
db: uniprot

uniprot P14784 237
type: UnificationXref
id: P14784
db: uniprot

uniprot A0A2I3T4Q0 125
type: UnificationXref
id: A0A2I3T4Q0
db: uniprot

uniprot E2RKR0 126
type: UnificationXref
id: E2RKR0
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F1P859 301
organism: Canis lupus familiaris

uniprot F7FRY0 49
type: UnificationXref
id: F7FRY0
db: uniprot

mTOR s65 a108 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SRF s101 a169 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: uniprot P42345 114
xref: PTHR11139:SF9
organism: Homo sapiens

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: uniprot P49841 265
xref: PTHR24057:SF8
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r53 682
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

ETS domain-containing protein Elk-4
type: ProteinReference
xref: uniprot P41158 23
xref: PTHR11849:SF21
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r53 684
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 683
type: Stoichiometry
physical entity: MAPKAPK2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 685
type: Stoichiometry
physical entity: MAPKAPK2
stoichiometric coefficient: 1.0

uniprot Q5ZMM7 29
type: UnificationXref
id: Q5ZMM7
db: uniprot

IRS1 isoform 1
type: ProteinReference
xref: PTHR10614:SF11
xref: uniprot H2QJJ4 293
organism: Pan troglodytes

Signaling subunit
type: Protein
entity reference: Signaling subunit
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa6 548
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PI3K
type: Protein
entity reference: PI3K
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

MNK1/2
type: Protein
entity reference: MNK1/2
feature: MNK1 2 s83 a145 rs1
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR48019:SF40
type: RelationshipXref
id: PTHR48019:SF40
db: PANTHER Family
relationship type: By Homology

eNOS s55 a100 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_eNOS-RIGHT__ADP-_eNOS-_r41
controller: PKB

uniprot Q9JLN9 116
type: UnificationXref
id: Q9JLN9
db: uniprot

uniprot F7F3S0 395
type: UnificationXref
id: F7F3S0
db: uniprot

ncbitaxon 9544 15
type: UnificationXref
id: 9544
db: ncbitaxon

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot F7D2D3 508
organism: Monodelphis domestica

ncbitaxon 9606 20
type: UnificationXref
id: 9606
db: ncbitaxon

FKHRL1 s63 a107 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Signal transducer and activator of transcription 4
type: ProteinReference
xref: PTHR11801:SF19
xref: uniprot Q14765 527
organism: Homo sapiens

uniprot P42701 242
type: UnificationXref
id: P42701
db: uniprot

uniprot Q8TD08 103
type: UnificationXref
id: Q8TD08
db: uniprot

uniprot P26951 445
type: UnificationXref
id: P26951
db: uniprot

uniprot H2QJE0 430
type: UnificationXref
id: H2QJE0
db: uniprot

uniprot P10145 168
type: UnificationXref
id: P10145
db: uniprot

uniprot F6X0C8 232
type: UnificationXref
id: F6X0C8
db: uniprot

uniprot P16598 171
type: UnificationXref
id: P16598
db: uniprot

Interleukin-1 alpha
type: ProteinReference
xref: uniprot P16598 171
organism: Rattus norvegicus

mTOR s58 a103 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Interleukin-12 receptor subunit beta-2
type: ProteinReference
xref: uniprot P97378 243
xref: PTHR23036:SF79
organism: Mus musculus

uniprot D4A3T0 298
type: UnificationXref
id: D4A3T0
db: uniprot

uniprot A0A2I3T7A8 388
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

MAPKAPK2
type: Protein
entity reference: MAPKAPK2
feature: MAPKAPK2 s85 a146 rs1
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q38IC8 455
type: UnificationXref
id: Q38IC8
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A1D5QL06 33
xref: PTHR24351:SF98
organism: Macaca mulatta

CTMP
type: Protein
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q5F3W3 96
type: UnificationXref
id: Q5F3W3
db: uniprot

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: PTHR11139:SF9
xref: uniprot F7BA89 111
organism: Monodelphis domestica

uniprot P20607 173
type: UnificationXref
id: P20607
db: uniprot

uniprot A0A1D5QPR1 489
type: UnificationXref
id: A0A1D5QPR1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HHY8 285
xref: PTHR24349:SF63
organism: Macaca mulatta

HETERODIMER_ASSOCIATION_LEFT__Grb2-_SOS-_Shc-RIGHT__Complex__Grb2_Shc__SOS_-_r19
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 568
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 567
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 566
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 565
left: Grb2
left: Shc
left: SOS
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Grb2/Shc/ SOS)

uniprot E2RPJ2 68
type: UnificationXref
id: E2RPJ2
db: uniprot

uniprot P51492 183
type: UnificationXref
id: P51492
db: uniprot

ELK3 isoform 1
type: ProteinReference
xref: uniprot H2Q6N4 17
organism: Pan troglodytes

uniprot Q0IIE2 541
type: UnificationXref
id: Q0IIE2
db: uniprot

Ets
type: Protein
entity reference: Ets
feature: Ets s87 a139 rs1
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P18652 51
type: UnificationXref
id: P18652
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF3
xref: uniprot A0A2J8LTH4 277
organism: Pan troglodytes

GSK3 s36 a51 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F6QUW1 303
xref: PTHR23113:SF168
organism: Monodelphis domestica

Ikk
type: Protein
entity reference: Ikk
feature: Ikk s64 a109 rs1
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

SRF s99 a168 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

p27KIP1
type: Protein
entity reference: p27KIP1
feature: p27KIP1 s122 a114 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Myc proto-oncogene protein
type: ProteinReference
xref: PTHR45851:SF1
xref: uniprot Q2HJ27 487
organism: Bos taurus

PTHR45807:SF3
type: RelationshipXref
id: PTHR45807:SF3
db: PANTHER Family
relationship type: By Homology

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot Q9Y243 229
organism: Homo sapiens

PTHR24351:SF110
type: RelationshipXref
id: PTHR24351:SF110
db: PANTHER Family
relationship type: By Homology

Forkhead box protein O3
type: ProteinReference
xref: uniprot O43524 478
xref: PTHR45767:SF4
organism: Homo sapiens

uniprot F7HPR8 537
type: UnificationXref
id: F7HPR8
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot O93599 512
organism: Danio rerio

Interleukin-15
type: ProteinReference
xref: PTHR14356:SF3
xref: uniprot Q28028 188
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7FDA0 396
organism: Monodelphis domestica

PTHR11139:SF9
type: RelationshipXref
id: PTHR11139:SF9
db: PANTHER Family
relationship type: By Homology

Interleukin-11 receptor subunit alpha-2
type: ProteinReference
xref: uniprot P70225 447
xref: PTHR23036:SF29
organism: Mus musculus

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P40763 513
organism: Homo sapiens

Ets
type: Protein
entity reference: Ets
feature: Ets s77 a151 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

ELK s31 a44 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P47197 226
type: UnificationXref
id: P47197
db: uniprot

uniprot P11831 373
type: UnificationXref
id: P11831
db: uniprot

uniprot O88786 435
type: UnificationXref
id: O88786
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot E1B8P9 65
organism: Bos taurus

uniprot P18654 54
type: UnificationXref
id: P18654
db: uniprot

PARTICIPANT STOICHIOMETRY r44 604
type: Stoichiometry
physical entity: p21CIP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r44 603
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

MAP kinase-interacting serine/threonine-protein kinase 2
type: ProteinReference
xref: uniprot Q8CDB0 202
xref: PTHR24349:SF254
organism: Mus musculus

uniprot H2QLB4 82
type: UnificationXref
id: H2QLB4
db: uniprot

uniprot H2Q6N4 17
type: UnificationXref
id: H2Q6N4
db: uniprot

uniprot F6SHC1 128
type: UnificationXref
id: F6SHC1
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot K7CZM1 309
organism: Pan troglodytes

uniprot G3X7E9 426
type: UnificationXref
id: G3X7E9
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 46

STATE_TRANSITION_LEFT__ATP-_p27KIP1-RIGHT__p27KIP1-_ADP-_r45
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 598
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 597
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 596
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 595
left: p27KIP1
left: ATP
interaction type: STATE_TRANSITION
right: p27KIP1
right: ADP

PARTICIPANT STOICHIOMETRY r44 605
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot F7FDA0 396
type: UnificationXref
id: F7FDA0
db: uniprot

PARTICIPANT STOICHIOMETRY r44 606
type: Stoichiometry
physical entity: p21CIP1
stoichiometric coefficient: 1.0

uniprot Q95KV1 137
type: UnificationXref
id: Q95KV1
db: uniprot

Interleukin-12 receptor subunit beta-2
type: ProteinReference
xref: uniprot Q99665 249
xref: PTHR23036:SF79
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E823 75
xref: PTHR24055:SF203
organism: Monodelphis domestica

c fos s98 a167 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Glycoprotein 130
type: ProteinReference
xref: uniprot Q9W6U9 144
xref: PTHR23036:SF83
organism: Gallus gallus

MAPKAPK2 s82 a149 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Jak
type: Protein
entity reference: Jak
feature: Jak s125 a222 rs2
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A0A3Q1M614 281
type: UnificationXref
id: A0A3Q1M614
db: uniprot

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot A0A2I3TK00 326
xref: PTHR44329:SF47
organism: Pan troglodytes

uniprot F7FHD1 79
type: UnificationXref
id: F7FHD1
db: uniprot

Insulin receptor substrate 2
type: ProteinReference
xref: PTHR10614:SF7
xref: uniprot Q9Y4H2 297
organism: Homo sapiens

eco ECO:0000270 424
type: UnificationXref
id: ECO:0000270
db: eco

Nitric oxide synthase
type: ProteinReference
xref: uniprot A0A3Q1LSD1 360
xref: PTHR19384:SF66
organism: Bos taurus

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 13

PTHR16922:SF0
type: RelationshipXref
id: PTHR16922:SF0
db: PANTHER Family
relationship type: By Homology

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot F1PNW8 500
organism: Canis lupus familiaris

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F1MAI3 299
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r7 570
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

uniprot E2RJX4 210
type: UnificationXref
id: E2RJX4
db: uniprot

uniprot F7FMI1 421
type: UnificationXref
id: F7FMI1
db: uniprot

uniprot F7FXB6 140
type: UnificationXref
id: F7FXB6
db: uniprot

Serum response factor
type: ProteinReference
xref: uniprot F7FP88 370
xref: PTHR48019:SF40
organism: Monodelphis domestica

eco ECO:0000305 21
type: UnificationXref
id: ECO:0000305
db: eco

c-fos
type: ProteinReference
xref: P00967
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: c-fos Synonym: Synonym not specified Accession: P00967
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.c-fos
member entity reference: Proto-oncogene c-Fos
member entity reference: Fos proto-oncogene, AP-1 transcription factor subunit
member entity reference: C-fos
member entity reference: Uncharacterized protein

uniprot F7GAP5 398
type: UnificationXref
id: F7GAP5
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F7CHH2 506
xref: PTHR11801:SF47
organism: Monodelphis domestica

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PIP2-RIGHT__PIP3-_r33
controller: PI3K

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7EH19 76
xref: PTHR24055:SF203
organism: Xenopus tropicalis

uniprot F7H7W3 50
type: UnificationXref
id: F7H7W3
db: uniprot

PARTICIPANT STOICHIOMETRY r7 569
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_GSK3-RIGHT__ADP-_GSK3-_r36
controller: PKB

uniprot P09416 485
type: UnificationXref
id: P09416
db: uniprot

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: PTHR11139:SF9
xref: uniprot K7B4P2 113
organism: Pan troglodytes

uniprot H2R710 477
type: UnificationXref
id: H2R710
db: uniprot

uniprot A0A2I3THL4 325
type: UnificationXref
id: A0A2I3THL4
db: uniprot

Ribosomal protein S6 kinase alpha-3
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot P51812 55
organism: Homo sapiens

uniprot F7GWU7 407
type: UnificationXref
id: F7GWU7
db: uniprot

Interleukin
type: ProteinReference
xref: uniprot F7EGQ8 153
xref: PTHR14356:SF2
organism: Macaca mulatta

uniprot P47196 225
type: UnificationXref
id: P47196
db: uniprot

Ras GTPase-activating protein 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot P20936 255
organism: Homo sapiens

p90RSK
type: ProteinReference
xref: P00964
standard name: Ribosomal protein S6 kinase, 90kD
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.p90RSK
comment: ENTITY_REFERENCE_NOTES=Long Name: Ribosomal protein S6 kinase, 90kD Synonym: RPS6KA1,RSK1,p90RSK Accession: P00964
member entity reference: Ribosomal protein S6 kinase alpha-1
member entity reference: Ribosomal protein S6 kinase 2 alpha
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: Ribosomal protein S6 kinase
member entity reference: Ribosomal protein S6 kinase alpha-6
member entity reference: Ribosomal protein S6 kinase alpha-3
member entity reference: Ribosomal protein S6 kinase alpha-2

PARTICIPANT STOICHIOMETRY r49 580
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

Shc s16 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Shc
stoichiometric coefficient: 1.0

uniprot P40763 513
type: UnificationXref
id: P40763
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HN68 379
xref: PTHR11849:SF17
organism: Macaca mulatta

uniprot Q58D94 199
type: UnificationXref
id: Q58D94
db: uniprot

PTHR22969:SF13
type: RelationshipXref
id: PTHR22969:SF13
db: PANTHER Family
relationship type: By Homology

PKB
type: Protein
entity reference: PKB
feature: PKB s34 a49 rs1
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot O88351 134
organism: Mus musculus

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P47196 225
organism: Rattus norvegicus

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P47197 226
organism: Rattus norvegicus

FOXO3 isoform 1
type: ProteinReference
xref: PTHR45767:SF4
xref: uniprot H2R710 477
organism: Pan troglodytes

Interleukin 4 receptor
type: ProteinReference
xref: uniprot H2QAT6 429
xref: PTHR23037:SF32
organism: Pan troglodytes

IL12RB2 isoform 1
type: ProteinReference
xref: PTHR23036:SF79
xref: uniprot H2PZ74 234
organism: Pan troglodytes

uniprot F1PXV9 152
type: UnificationXref
id: F1PXV9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p90RSK-_ATP-RIGHT__ADP-_p90RSK-_r52
controller: ERK

Nitric oxide synthase
type: ProteinReference
xref: uniprot A0A1D5QGM1 359
xref: PTHR19384:SF66
organism: Macaca mulatta

uniprot P15247 169
type: UnificationXref
id: P15247
db: uniprot

PARTICIPANT STOICHIOMETRY r49 579
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

uniprot E2RDB5 290
type: UnificationXref
id: E2RDB5
db: uniprot

uniprot A0A140T8E9 145
type: UnificationXref
id: A0A140T8E9
db: uniprot

PARTICIPANT STOICHIOMETRY r59 666
type: Stoichiometry
physical entity: SRF
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_ELK-RIGHT__ADP-_ELK-_r10
controller: ERK

PTHR24070:SF189
type: RelationshipXref
id: PTHR24070:SF189
db: PANTHER Family
relationship type: By Homology

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A2I3S8A4 34
xref: PTHR24351:SF98
organism: Pan troglodytes

Mitogen-activated protein kinase 7
type: ProteinReference
xref: PTHR24055:SF356
xref: uniprot Q13164 92
organism: Homo sapiens

GSK3
type: Protein
entity reference: GSK3
feature: GSK3 s36 a51 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot A2VE30 416
type: UnificationXref
id: A2VE30
db: uniprot

PARTICIPANT STOICHIOMETRY r72 625
type: Stoichiometry
physical entity: Jak
stoichiometric coefficient: 1.0

uniprot P48346 182
type: UnificationXref
id: P48346
db: uniprot

PARTICIPANT STOICHIOMETRY r72 624
type: Stoichiometry
physical entity: Jak
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r72 626
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 691
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 690
type: Stoichiometry
physical entity: MNK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r72 623
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

MNK1/2
type: ProteinReference
xref: P00972
standard name: Mitogen-activated protein kinase-interacting serine/threonine kinase1/2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.MNK1/2
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen-activated protein kinase-interacting serine/threonine kinase1/2 Synonym: MAPK-interacting kinase 1/2,MKNK1/2,MNK1/2 Accession: P00972
member entity reference: MAP kinase-interacting serine/threonine-protein kinase 2 isoform 2
member entity reference: Uncharacterized protein
member entity reference: MAP kinase interacting serine/threonine kinase 2
member entity reference: MAP kinase-interacting serine/threonine-protein kinase 1
member entity reference: MAP kinase-interacting serine/threonine-protein kinase 2

Interleukin-13 receptor subunit alpha-1
type: ProteinReference
xref: uniprot O09030 434
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r59 667
type: Stoichiometry
physical entity: SRF
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7F3S0 395
organism: Macaca mulatta

uniprot P16382 439
type: UnificationXref
id: P16382
db: uniprot

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa1 552
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P07750 165
type: UnificationXref
id: P07750
db: uniprot

PARTICIPANT STOICHIOMETRY r51 692
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 693
type: Stoichiometry
physical entity: MNK1/2
stoichiometric coefficient: 1.0

Interleukin-15
type: ProteinReference
xref: PTHR14356:SF3
xref: uniprot P48346 182
organism: Mus musculus

PTHR24055:SF356
type: RelationshipXref
id: PTHR24055:SF356
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_r59
controller: MAPKAPK2

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF48
xref: uniprot Q1KQ07 528
organism: Rattus norvegicus

Nitric oxide synthase
type: ProteinReference
xref: uniprot H2QVM2 362
xref: PTHR19384:SF66
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_c_Myc-RIGHT__c_Myc-_ADP-_r54
controller: ERK

mTOR
type: Protein
entity reference: mTOR
feature: mTOR s65 a108 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot H2QJJ4 293
type: UnificationXref
id: H2QJJ4
db: uniprot

PKB s34 a49 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot F1Q3M8 390
type: UnificationXref
id: F1Q3M8
db: uniprot

PTHR23036:SF101
type: RelationshipXref
id: PTHR23036:SF101
db: PANTHER Family
relationship type: By Homology

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 105

IL23A isoform 3
type: ProteinReference
xref: PTHR15947:SF0
xref: uniprot H2Q687 428
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6V2H6 72
xref: PTHR24055:SF171
organism: Monodelphis domestica

uniprot F6UNV6 43
type: UnificationXref
id: F6UNV6
db: uniprot

STATE_TRANSITION_LEFT__ATP-_GSK3-RIGHT__ADP-_GSK3-_r36
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 647
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 646
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 648
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 649
left: ATP
left: GSK3
interaction type: STATE_TRANSITION
right: GSK3
right: ADP

Interleukin-23 subunit alpha
type: ProteinReference
xref: uniprot F7HQI5 422
xref: PTHR15947:SF0
organism: Macaca mulatta

Grb2 s15 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

uniprot P21183 440
type: UnificationXref
id: P21183
db: uniprot

Son of sevenless homolog 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot H9FYU7 308
organism: Macaca mulatta

uniprot P42337 403
type: UnificationXref
id: P42337
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: Ets

PTHR19384:SF66
type: RelationshipXref
id: PTHR19384:SF66
db: PANTHER Family
relationship type: By Homology

uniprot Q9VR61 59
type: UnificationXref
id: Q9VR61
db: uniprot

uniprot Q2YEG0 454
type: UnificationXref
id: Q2YEG0
db: uniprot

uniprot P26892 175
type: UnificationXref
id: P26892
db: uniprot

uniprot P42230 520
type: UnificationXref
id: P42230
db: uniprot

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

ELK4, ETS transcription factor
type: ProteinReference
xref: PTHR11849:SF21
xref: uniprot B4F7D4 10
organism: Rattus norvegicus

PTHR10337:SF2
type: RelationshipXref
id: PTHR10337:SF2
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NCY7 282
organism: Gallus gallus

MAPKAPK2 s85 a146 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q9Z2A0 358
organism: Mus musculus

Src-like
type: ProteinReference
xref: P00991
standard name: Src-like-adapter 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.Src-like
comment: ENTITY_REFERENCE_NOTES=Long Name: Src-like protein tyrosine kinase (PTK) family Synonym: Blk,Bsk),Fgr,Fyn,Gtk,Hck,Lck,Lyn,Rak (Frk,Yes,family includes Src Accession: P00991
member entity reference: SLA2 isoform 1
member entity reference: Uncharacterized protein
member entity reference: Src-like-adapter 2

PTHR24351:SF98
type: RelationshipXref
id: PTHR24351:SF98
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 15
type: ProteinReference
xref: uniprot Q9Z2A6 106
xref: PTHR24055:SF79
organism: Rattus norvegicus

Tyrosine-protein kinase JAK3
type: ProteinReference
xref: PTHR45807:SF3
xref: uniprot P52333 279
organism: Homo sapiens

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot A5PKJ4 64
xref: PTHR24055:SF356
organism: Bos taurus

PI3K
type: ProteinReference
xref: P00990
standard name: Phosphatidylinositol 3-kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: PI3K Synonym: Synonym not specified Accession: P00990
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.PI3K
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

uniprot P41969 25
type: UnificationXref
id: P41969
db: uniprot

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: uniprot F6U298 350
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r12 602
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7FHD1 79
xref: PTHR24055:SF203
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r12 600
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r12 601
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot O55173 356
organism: Rattus norvegicus

PTHR23036:SF29
type: RelationshipXref
id: PTHR23036:SF29
db: PANTHER Family
relationship type: By Homology

FKHRL1 s56 a101 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Grb2-_SOS-_Shc-RIGHT__Complex__Grb2_Shc__SOS_-_r19
controller: Complex (Receptor subunit alpha/Receptor subunit beta/ Signaling subunit/Interleukin)

uniprot Q5U2N4 200
type: UnificationXref
id: Q5U2N4
db: uniprot

Interleukin
type: ProteinReference
xref: uniprot F1NZN5 150
organism: Gallus gallus

Serine/threonine-protein kinase TOR
type: ProteinReference
xref: uniprot F1NUX4 110
xref: PTHR11139:SF9
organism: Gallus gallus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: STAT

Interleukin-6
type: ProteinReference
xref: uniprot Q90YI0 189
organism: Gallus gallus

uniprot P20809 174
type: UnificationXref
id: P20809
db: uniprot

STAT s20 a28 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.870260612568485
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

ncbitaxon 10090 24
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot E2REI6 329
type: UnificationXref
id: E2REI6
db: uniprot

RAS p21 protein activator (GTPase activating protein) 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot H2QR74 254
organism: Pan troglodytes

uniprot F6U605 418
type: UnificationXref
id: F6U605
db: uniprot

uniprot F6UWI0 44
type: UnificationXref
id: F6UWI0
db: uniprot

STAT
type: Protein
entity reference: STAT
feature: STAT s20 a28 rs2
feature: STAT s20 a28 rs1
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r32
controller: IRS1/2

PARTICIPANT STOICHIOMETRY r42 618
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: uniprot A0A2I3SXI2 257
xref: PTHR24057:SF8
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r42 615
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

c-fos
type: Protein
entity reference: c-fos
feature: c fos s96 a166 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r42 616
type: Stoichiometry
physical entity: FKHRL1
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PKB-RIGHT__PKB-_ADP-_r35
controller: PDK1/2

PARTICIPANT STOICHIOMETRY r42 617
type: Stoichiometry
physical entity: FKHRL1
stoichiometric coefficient: 1.0

uniprot F7DUD6 394
type: UnificationXref
id: F7DUD6
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 346
xref: PTHR44329:SF22
xref: uniprot Q99N57 345
organism: Mus musculus

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 20

Interleukin-13 receptor subunit alpha-1
type: ProteinReference
xref: PTHR23036:SF89
xref: uniprot P78552 448
organism: Homo sapiens

STAT s20 a28 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot E2RNA9 127
type: UnificationXref
id: E2RNA9
db: uniprot

uniprot P49841 265
type: UnificationXref
id: P49841
db: uniprot

SOS
type: Protein
entity reference: SOS
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

eco ECO:0000353 105
type: UnificationXref
id: ECO:0000353
db: eco

uniprot P01590 437
type: UnificationXref
id: P01590
db: uniprot

uniprot P63086 91
type: UnificationXref
id: P63086
db: uniprot

uniprot F7FP88 370
type: UnificationXref
id: F7FP88
db: uniprot

Signaling subunit
type: ProteinReference
xref: P00969
comment: ENTITY_REFERENCE_NOTES=Long Name: Signaling subunit Synonym: Synonym not specified Accession: P00969
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.RECEPTOR.Signaling_br_subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Uncharacterized protein
member entity reference: Interleukin-6 receptor subunit beta
member entity reference: IL6ST isoform 1
member entity reference: Glycoprotein 130

PTHR24351:SF43
type: RelationshipXref
id: PTHR24351:SF43
db: PANTHER Family
relationship type: By Homology

uniprot A0A3Q1LNQ6 36
type: UnificationXref
id: A0A3Q1LNQ6
db: uniprot

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: uniprot Q60680 135
xref: PTHR22969:SF13
organism: Mus musculus

PTHR23036:SF17
type: RelationshipXref
id: PTHR23036:SF17
db: PANTHER Family
relationship type: By Homology

uniprot Q5F352 276
type: UnificationXref
id: Q5F352
db: uniprot

MNK1 2 s83 a145 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Cyclin dependent kinase inhibitor
type: ProteinReference
xref: uniprot O08769 317
xref: PTHR10265:SF9
organism: Rattus norvegicus

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot A0A1D5NWT4 32
organism: Gallus gallus

PTHR24351:SF58
type: RelationshipXref
id: PTHR24351:SF58
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__c_fos-RIGHT__c_fos-_r58
controller: p90RSK

Interleukin-1
type: ProteinReference
xref: PTHR10078:SF33
xref: uniprot A0A140T8E9 145
organism: Canis lupus familiaris

ERK
type: Protein
entity reference: ERK
feature: ERK s24 a34 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

STAT
type: Complex
component stoichiometry: STAT s113 a173 STOICHIOMETRY ID COMPLEX
component: STAT
feature: ACTIVE 31
cellular location: cytoplasm

uniprot H2QW34 131
type: UnificationXref
id: H2QW34
db: uniprot

STAT
type: Complex
component stoichiometry: STAT s115 a175 STOICHIOMETRY ID COMPLEX
component: STAT
feature: ACTIVE 31
cellular location: nucleus

PTHR11849:SF174
type: RelationshipXref
id: PTHR11849:SF174
db: PANTHER Family
relationship type: By Homology

STAT
type: Complex
component stoichiometry: STAT s116 a176 STOICHIOMETRY ID COMPLEX
component: STAT
feature: ACTIVE 31
cellular location: nucleus

ncbitaxon 7668 269
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot F6R8N3 217
type: UnificationXref
id: F6R8N3
db: uniprot

eNOS
type: Protein
entity reference: eNOS
feature: eNOS s62 a106 rs1
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Interleukin-11 receptor subunit alpha
type: ProteinReference
xref: PTHR23036:SF29
xref: uniprot Q99MF4 466
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q9VR61 59
xref: PTHR24351:SF110
organism: Drosophila melanogaster

Interleukin-11
type: ProteinReference
xref: uniprot Q99MF5 190
organism: Rattus norvegicus

PTHR11849:SF178
type: RelationshipXref
id: PTHR11849:SF178
db: PANTHER Family
relationship type: By Homology

Receptor subunit beta
type: Protein
entity reference: Receptor subunit beta
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

c Myc s76 a150 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot H2QAT6 429
type: UnificationXref
id: H2QAT6
db: uniprot

uniprot P49138 288
type: UnificationXref
id: P49138
db: uniprot

ERK
type: ProteinReference
xref: P00965
standard name: Extracellular signal-regulated kinase family
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Extracellular signal-regulated kinase family Synonym: ERK,Maturation- or mitogen-activated protein (MAP) kinase family Accession: P00965
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.ERK
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase 7
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Extracellular signal-regulated kinase 1
member entity reference: Mitogen-activated protein kinase 15
member entity reference: Mitogen-activated protein kinase 6
member entity reference: Uncharacterized protein
member entity reference: MAPK6 isoform 1

uniprot A0A2I3RU68 147
type: UnificationXref
id: A0A2I3RU68
db: uniprot

Interleukin-8
type: ProteinReference
xref: uniprot P79255 186
xref: PTHR10179:SF42
organism: Bos taurus

PTHR23036:SF175
type: RelationshipXref
id: PTHR23036:SF175
db: PANTHER Family
relationship type: By Homology

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: uniprot A0A2I3T4Q0 125
xref: PTHR22969:SF13
organism: Pan troglodytes

Interleukin 13 receptor, alpha 1
type: ProteinReference
xref: PTHR23036:SF89
xref: uniprot Q561K3 456
organism: Rattus norvegicus

PTHR10511:SF3
type: RelationshipXref
id: PTHR10511:SF3
db: PANTHER Family
relationship type: By Homology

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 21

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 107

PKB
type: Protein
entity reference: PKB
feature: PKB s121 a112 rs1
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q5F3U4 357
type: UnificationXref
id: Q5F3U4
db: uniprot

PTHR23036:SF170
type: RelationshipXref
id: PTHR23036:SF170
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F1MYM3 389
organism: Bos taurus

uniprot P08556 274
type: UnificationXref
id: P08556
db: uniprot

uniprot Q9Z1L0 406
type: UnificationXref
id: Q9Z1L0
db: uniprot

uniprot P21708 86
type: UnificationXref
id: P21708
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A3Q1LNQ6 36
xref: PTHR24351:SF213
organism: Bos taurus

STATE_TRANSITION_LEFT__ATP-_IRS1_2-RIGHT__ADP-_IRS1_2-_r16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 584
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 582
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 583
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 581
left: ATP
left: IRS1/2
interaction type: STATE_TRANSITION
right: ADP
right: IRS1/2

uniprot H2QLZ0 431
type: UnificationXref
id: H2QLZ0
db: uniprot

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot P0C865 85
xref: PTHR24055:SF356
organism: Rattus norvegicus

uniprot F7EPN2 253
type: UnificationXref
id: F7EPN2
db: uniprot

uniprot A0A2I3RAL0 412
type: UnificationXref
id: A0A2I3RAL0
db: uniprot

uniprot P31750 223
type: UnificationXref
id: P31750
db: uniprot

uniprot P42226 516
type: UnificationXref
id: P42226
db: uniprot

uniprot P32871 401
type: UnificationXref
id: P32871
db: uniprot

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot Q9WVS8 104
xref: PTHR24055:SF356
organism: Mus musculus

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: uniprot P28028 343
xref: PTHR44329:SF47
organism: Mus musculus

Interleukin-6 receptor subunit alpha
type: ProteinReference
xref: uniprot P22272 441
organism: Mus musculus

Interleukin-6 receptor subunit alpha
type: ProteinReference
xref: uniprot P22273 442
xref: PTHR23036:SF98
organism: Rattus norvegicus

Receptor subunit alpha s1 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Receptor subunit alpha
stoichiometric coefficient: 1.0

uniprot H2PZ74 234
type: UnificationXref
id: H2PZ74
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A3Q1LXK8 37
xref: PTHR24351:SF98
organism: Bos taurus

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: uniprot E1BFB4 108
xref: PTHR11139:SF9
organism: Bos taurus

Pro-interleukin-16
type: ProteinReference
xref: uniprot D4A4I9 149
organism: Rattus norvegicus

uniprot A0A1D5QB09 289
type: UnificationXref
id: A0A1D5QB09
db: uniprot

MAPKAPK2
type: Protein
entity reference: MAPKAPK2
feature: MAPKAPK2 s95 a153 rs1
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F1MYJ4 212
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_FKHRL1-RIGHT__FKHRL1-_ADP-_r42
controller: PKB

STATE_TRANSITION_LEFT__ERK-_ATP-RIGHT__ADP-_ERK-_r9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 557
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 560
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 559
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 558
left: ERK
left: ATP
interaction type: STATE_TRANSITION
right: ERK
right: ADP

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PDK1_2-_ATP-RIGHT__PDK1_2-_ADP-_r34
controller: PIP3

Candida albicans
type: BioSource
xref: ncbitaxon 237561 95

PARTICIPANT STOICHIOMETRY r38 636
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r38 635
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r38 634
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

uniprot A0A3Q1MLN6 38
type: UnificationXref
id: A0A3Q1MLN6
db: uniprot

C-X-C chemokine receptor type 1
type: ProteinReference
xref: PTHR10489:SF916
xref: uniprot H2QJE0 430
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r38 633
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

C-fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot A5A6H0 117
organism: Pan troglodytes

TRANSPORT_LEFT__PKB-RIGHT__PKB-_r39
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 632
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 631
left: PKB
interaction type: TRANSPORT
right: PKB

SHC-transforming protein 1
type: ProteinReference
xref: uniprot P98083 540
xref: PTHR10337:SF2
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot E2RJX4 210
organism: Canis lupus familiaris

C-fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot A5A6H2 118
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r19 566
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot H2QNG6 399
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r19 567
type: Stoichiometry
physical entity: Shc
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F1Q4F8 214
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r19 565
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r19 568
type: Stoichiometry
physical entity: Complex (Grb2/Shc/ SOS)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r33 663
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 53

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot A0A0G2K3R1 347
organism: Rattus norvegicus

Src-like-adapter 2
type: ProteinReference
xref: PTHR10155:SF6
xref: uniprot Q9H6Q3 409
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r33 662
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

uniprot A0A2I3TQ88 493
type: UnificationXref
id: A0A2I3TQ88
db: uniprot

uniprot P26955 241
type: UnificationXref
id: P26955
db: uniprot

uniprot Q66JF3 201
type: UnificationXref
id: Q66JF3
db: uniprot

uniprot P15248 170
type: UnificationXref
id: P15248
db: uniprot

TRANSPORT_LEFT__p27KIP1-RIGHT__p27KIP1-_r47
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 588
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 589
left: p27KIP1
interaction type: TRANSPORT
right: p27KIP1

Transcription factor PU.1
type: ProteinReference
xref: PTHR11849:SF16
xref: uniprot P17433 381
organism: Mus musculus

STATE_TRANSITION_LEFT__STAT-RIGHT__STAT-_r66
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 657
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 656
left: STAT
interaction type: STATE_TRANSITION
right: STAT

Uncharacterized protein
type: ProteinReference
xref: PTHR23036:SF83
xref: uniprot F7FXB6 140
organism: Macaca mulatta

uniprot F7D2D3 508
type: UnificationXref
id: F7D2D3
db: uniprot

PTHR24055:SF79
type: RelationshipXref
id: PTHR24055:SF79
db: PANTHER Family
relationship type: By Homology

Interleukin
type: Protein
entity reference: Interleukin
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5QF27 411
type: UnificationXref
id: A0A1D5QF27
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF48
xref: uniprot F1MGJ4 497
organism: Bos taurus

MAPKAPK2
type: Protein
entity reference: MAPKAPK2
feature: MAPKAPK2 s82 a149 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF19
xref: uniprot F7CW94 507
organism: Monodelphis domestica

PKB s121 a112 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

STAT s115 a175 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P08505 166
type: UnificationXref
id: P08505
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 335
evidence: Evidence 334
xref: PTHR44329:SF22
xref: uniprot P04049 333
organism: Homo sapiens

uniprot A0A2I3TN41 353
type: UnificationXref
id: A0A2I3TN41
db: uniprot

Interleukin-11
type: ProteinReference
xref: PTHR16922:SF0
xref: uniprot P20809 174
organism: Homo sapiens

Interleukin-11 receptor subunit alpha
type: ProteinReference
xref: uniprot Q14626 452
xref: PTHR23036:SF29
organism: Homo sapiens

Interleukin 5 receptor subunit alpha
type: ProteinReference
xref: PTHR23036:SF17
xref: uniprot G3V6S7 423
organism: Rattus norvegicus

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF176
type: RelationshipXref
id: PTHR24356:SF176
db: PANTHER Family
relationship type: By Homology

uniprot P17433 381
type: UnificationXref
id: P17433
db: uniprot

Serine/threonine-protein kinase mTOR
type: ProteinReference
xref: uniprot E2R2L2 109
xref: PTHR11139:SF9
organism: Canis lupus familiaris

uniprot O77628 121
type: UnificationXref
id: O77628
db: uniprot

Interleukin-13 receptor subunit alpha-2
type: ProteinReference
xref: PTHR23036:SF101
xref: uniprot Q14627 453
organism: Homo sapiens

RasGAP
type: Protein
entity reference: RasGAP
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

p27KIP1 s60 a105 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A2I3T9Y4 207
xref: PTHR24356:SF190
organism: Pan troglodytes

uniprot G3V926 130
type: UnificationXref
id: G3V926
db: uniprot

Interleukin-4
type: ProteinReference
xref: uniprot P51492 183
organism: Macaca mulatta

Signal transducer and activator of transcription 2
type: ProteinReference
xref: PTHR11801:SF41
xref: uniprot Q9WVL2 533
organism: Mus musculus

uniprot Q61190 248
type: UnificationXref
id: Q61190
db: uniprot

Interleukin-6
type: ProteinReference
xref: uniprot P51494 184
organism: Macaca mulatta

uniprot Q01344 449
type: UnificationXref
id: Q01344
db: uniprot

Cyclin-dependent kinase inhibitor 1A
type: ProteinReference
xref: PTHR46778:SF1
xref: uniprot Q64315 473
organism: Rattus norvegicus

uniprot Q9QY78 138
type: UnificationXref
id: Q9QY78
db: uniprot

PTHR24356:SF190
type: RelationshipXref
id: PTHR24356:SF190
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6U605 418
organism: Macaca mulatta

uniprot P31749 222
type: UnificationXref
id: P31749
db: uniprot

uniprot P01582 161
type: UnificationXref
id: P01582
db: uniprot

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot O77628 121
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r52 688
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r52 689
type: Stoichiometry
physical entity: p90RSK
stoichiometric coefficient: 1.0

PKB s12 a18 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot P35569 295
type: UnificationXref
id: P35569
db: uniprot

uniprot A0A2I3SUM2 148
type: UnificationXref
id: A0A2I3SUM2
db: uniprot

uniprot Q28028 188
type: UnificationXref
id: Q28028
db: uniprot

uniprot F6Y841 393
type: UnificationXref
id: F6Y841
db: uniprot

STAT s115 a175 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.870260612568485
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY r52 686
type: Stoichiometry
physical entity: p90RSK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r52 687
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6V2V1 45
xref: PTHR24351:SF58
organism: Ornithorhynchus anatinus

uniprot Q99MF5 190
type: UnificationXref
id: Q99MF5
db: uniprot

uniprot Q4G050 198
type: UnificationXref
id: Q4G050
db: uniprot

PARTICIPANT STOICHIOMETRY r57 671
type: Stoichiometry
physical entity: MAPKAPK2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r57 670
type: Stoichiometry
physical entity: MAPKAPK2
stoichiometric coefficient: 1.0

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot A4GTP4 6
organism: Rattus norvegicus

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF47
xref: uniprot A0A1D5QPR1 489
organism: Macaca mulatta

STAT s113 a173 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.870260612568485
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot O08648 351
type: UnificationXref
id: O08648
db: uniprot

uniprot Q9JM73 374
type: UnificationXref
id: Q9JM73
db: uniprot

uniprot Q16659 93
type: UnificationXref
id: Q16659
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF48
xref: uniprot K7D3K8 511
organism: Pan troglodytes

Cyclin-dependent kinase inhibitor 1B
type: ProteinReference
xref: uniprot P46527 319
organism: Homo sapiens

Galactose-1-phosphate uridylyltransferase
type: ProteinReference
xref: uniprot A0A2I3SE97 414
xref: PTHR23036:SF29
organism: Pan troglodytes

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot Q95KV0 136
organism: Bos taurus

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: uniprot Q95KV1 137
xref: PTHR22969:SF13
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r6 575
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 576
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot P46414 318
type: UnificationXref
id: P46414
db: uniprot

STAT s113 a173 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 18

MAPKAPK2 isoform 1
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot H2Q104 286
organism: Pan troglodytes

uniprot Q9WV60 266
type: UnificationXref
id: Q9WV60
db: uniprot

uniprot A0A140T878 488
type: UnificationXref
id: A0A140T878
db: uniprot

PARTICIPANT STOICHIOMETRY r68 642
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r68 643
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r68 644
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r68 645
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 577
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot Q28807 246
type: UnificationXref
id: Q28807
db: uniprot

PARTICIPANT STOICHIOMETRY r6 578
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
evidence: Evidence 324
evidence: Evidence 322
evidence: Evidence 323
evidence: Evidence 321
xref: uniprot A0A1D5R9U8 320
xref: PTHR44329:SF22
organism: Macaca mulatta

GTP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Ikk-RIGHT__Ikk-_ADP-_r40
controller: PKB

uniprot F1MYM3 389
type: UnificationXref
id: F1MYM3
db: uniprot

uniprot F1PGU6 315
type: UnificationXref
id: F1PGU6
db: uniprot

STAT
type: Protein
entity reference: STAT
feature: STAT s116 a176 rs1
feature: ACTIVE 31
feature: STAT s116 a176 rs2

uniprot P20096 172
type: UnificationXref
id: P20096
db: uniprot

c-fos
type: Protein
entity reference: c-fos
feature: ACTIVE 31
feature: c fos s98 a167 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Forkhead box protein O3
type: ProteinReference
xref: uniprot Q9WVH4 479
xref: PTHR45767:SF4
organism: Mus musculus

uniprot Q60680 135
type: UnificationXref
id: Q60680
db: uniprot

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: uniprot E2RNA9 127
xref: PTHR22969:SF13
organism: Canis lupus familiaris

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 340
xref: PTHR44329:SF22
xref: uniprot P11345 339
organism: Rattus norvegicus

Nitric oxide synthase, endothelial
type: ProteinReference
xref: uniprot P29474 363
xref: PTHR19384:SF66
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r12 599
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

p21CIP1 s66 a113 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Interleukin signaling pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_Pi-_r14
pathway component: STATE_TRANSITION_LEFT__ATP-_p21CIP1-RIGHT__ADP-_p21CIP1-_r44
pathway component: STATE_TRANSITION_LEFT__ATP-_Src_like-RIGHT__ADP-_Src_like-_r18
pathway component: STATE_TRANSITION_LEFT__ATP-_p27KIP1-RIGHT__p27KIP1-_ADP-_r45
pathway component: STATE_TRANSITION_LEFT__STAT-RIGHT__STAT-_r66
pathway component: PHYSICAL_STIMULATION
pathway component: STATE_TRANSITION_LEFT__ERK-_ATP-RIGHT__ADP-_ERK-_r9
pathway component: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r32
pathway component: STATE_TRANSITION_LEFT__ATP-_ELK-RIGHT__ADP-_ELK-_r10
pathway component: STATE_TRANSITION_LEFT__p90RSK-_ATP-RIGHT__ADP-_p90RSK-_r52
pathway component: STATE_TRANSITION_LEFT__ATP-_Ets-RIGHT__Ets-_ADP-_r55
pathway component: TRANSPORT_LEFT__p90RSK-RIGHT__p90RSK-_r56
pathway component: STATE_TRANSITION_LEFT__PKB-RIGHT__Pi-_PKB-_r48
pathway component: TRANSPORT_LEFT__MAPKAPK2-RIGHT__MAPKAPK2-_r57
pathway component: STATE_TRANSITION_LEFT__ATP-_MAPKAPK2-RIGHT__ADP-_MAPKAPK2-_r53
pathway component: STATE_TRANSITION_LEFT__ATP-_STAT-RIGHT__STAT-_ADP-_r68
pathway component: STATE_TRANSITION_LEFT__ATP-_BAD-RIGHT__ADP-_BAD-_r38
pathway component: STATE_TRANSITION_LEFT__ATP-_PKB-RIGHT__PKB-_ADP-_r35
pathway component: HETERODIMER_ASSOCIATION_LEFT__Grb2-_SOS-_Shc-RIGHT__Complex__Grb2_Shc__SOS_-_r19
pathway component: STATE_TRANSITION_LEFT__ATP-_eNOS-RIGHT__ADP-_eNOS-_r41
pathway component: STATE_TRANSITION_LEFT__ATP-_MEK-RIGHT__MEK-_ADP-_r8
pathway component: STATE_TRANSITION_LEFT__ATP-_FKHRL1-RIGHT__FKHRL1-_ADP-_r42
pathway component: TRANSPORT_LEFT__STAT-RIGHT__STAT-_r67
pathway component: STATE_TRANSITION_LEFT__ATP-_mTOR-RIGHT__ADP-_mTOR-_r43
pathway component: STATE_TRANSITION_LEFT__PDK1_2-_ATP-RIGHT__PDK1_2-_ADP-_r34
pathway component: STATE_TRANSITION_LEFT__ATP-_c_Myc-RIGHT__c_Myc-_ADP-_r54
pathway component: STATE_TRANSITION_LEFT__ATP-_GSK3-RIGHT__ADP-_GSK3-_r36
pathway component: TRANSPORT_LEFT__ERK-RIGHT__ERK-_r49
pathway component: STATE_TRANSITION_LEFT__MNK1_2-_ATP-RIGHT__ADP-_MNK1_2-_r51
pathway component: STATE_TRANSITION_LEFT__c_fos-RIGHT__c_fos-_r58
pathway component: STATE_TRANSITION_LEFT__PIP2-RIGHT__PIP3-_r33
pathway component: STATE_TRANSITION_LEFT__ATP-_Jak-RIGHT__Jak-_ADP-_r72
pathway component: TRANSPORT_LEFT__p27KIP1-RIGHT__p27KIP1-_r47
pathway component: STATE_TRANSITION_LEFT__ATP-_IRS1_2-RIGHT__ADP-_IRS1_2-_r16
pathway component: TRANSPORT_LEFT__PKB-RIGHT__PKB-_r39
pathway component: STATE_TRANSITION_LEFT__ATP-_STAT-RIGHT__STAT-_ADP-_r12
pathway component: STATE_TRANSITION_LEFT__ATP-_Ikk-RIGHT__Ikk-_ADP-_r40
pathway component: STATE_TRANSITION_LEFT__Ras-_GTP-RIGHT__GDP-_Ras-_r6
pathway component: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r7
pathway component: HETERODIMER ASSOCIATION LEFT Receptor subunit alpha- Receptor subunit beta- Interleukin- Signaling subunit-RIGHT Complex Receptor subunit alpha Receptor subunit beta Signaling subunit Interleukin - r69
pathway component: STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_r59
pathway component: TRANSPORT_LEFT__p21CIP1-RIGHT__p21CIP1-_r46
xref: PANTHER Pathway P00036 1
comment: MODEL_NOTES=Panther Pathway: P00036 Interleukin is a term used to describe a subset of cytokines that are secreted by some leukocytes and acts upon other leukocytes. Many interleukins have pleiotropic effects on different target cells. They can mediate different biological response via activation of a combination of different siganl transduction pathways, including the Jak-STAT, ERK, and PI3K-PKB pathways. Medline=11701324 Medline=11861597 Medline=11865181 Medline=1590989 Medline=8970723 Medline=9269296 PMID: 11701324 PMID: 11861597 PMID: 11865181 PMID: 1590989 PMID: 8970723 PMID: 9269296

Mitogen-activated protein kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot A0A3Q1M614 281
xref: PTHR24349:SF63
organism: Bos taurus

uniprot A0A1D5R9X3 491
type: UnificationXref
id: A0A1D5R9X3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot F6TFL4 71
organism: Monodelphis domestica

Interleukin-5 receptor subunit alpha
type: ProteinReference
xref: PTHR23036:SF17
xref: uniprot P21183 440
organism: Mus musculus

Shc
type: ProteinReference
xref: P00997
standard name: SH2 homology domain containing transforming protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Shc Synonym: Synonym not specified Accession: P00997
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.Shc
member entity reference: SHC-transforming protein 1
member entity reference: SHC (Src homology 2 domain containing) transforming protein 1
member entity reference: Uncharacterized protein

PTHR23351:SF4
type: RelationshipXref
id: PTHR23351:SF4
db: PANTHER Family
relationship type: By Homology

uniprot P18653 52
type: UnificationXref
id: P18653
db: uniprot

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q04970 275
organism: Rattus norvegicus

PTHR24356:SF163
type: RelationshipXref
id: PTHR24356:SF163
db: PANTHER Family
relationship type: By Homology

Son of sevenless homolog 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot Q07890 312
organism: Homo sapiens

uniprot H9FVU5 400
type: UnificationXref
id: H9FVU5
db: uniprot

uniprot Q8CDB0 202
type: UnificationXref
id: Q8CDB0
db: uniprot

uniprot P18266 264
type: UnificationXref
id: P18266
db: uniprot

Multifunctional fusion protein
type: ProteinReference
xref: uniprot H2QPN2 156
xref: PTHR10179:SF42
organism: Pan troglodytes

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot Q5F3W3 96
xref: PTHR24055:SF171
organism: Gallus gallus

uniprot F7HQI5 422
type: UnificationXref
id: F7HQI5
db: uniprot

uniprot P01101 123
type: UnificationXref
id: P01101
db: uniprot

uniprot F6X927 129
type: UnificationXref
id: F6X927
db: uniprot

STATE_TRANSITION_LEFT__ATP-_mTOR-RIGHT__ADP-_mTOR-_r43
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 610
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 607
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 608
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 609
left: mTOR
left: ATP
interaction type: STATE_TRANSITION
right: mTOR
right: ADP

uniprot P42229 519
type: UnificationXref
id: P42229
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF48
xref: uniprot F1PAY3 499
organism: Canis lupus familiaris

Mitogen-activated protein kinase 6
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot G5E577 80
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
evidence: Evidence 195
xref: uniprot F6TJU6 194
xref: PTHR24349:SF114
organism: Macaca mulatta

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 15

ncbitaxon 9031 30
type: UnificationXref
id: 9031
db: ncbitaxon

Mitogen-activated protein kinase 15
type: ProteinReference
xref: PTHR24055:SF79
xref: uniprot Q80Y86 102
organism: Mus musculus

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P04627 336
xref: PTHR44329:SF55
organism: Mus musculus

STATE_TRANSITION_LEFT__ATP-_ELK-RIGHT__ADP-_ELK-_r10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 614
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 612
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 611
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 613
left: ATP
left: ELK
interaction type: STATE_TRANSITION
right: ADP
right: ELK

uniprot F1NUX4 110
type: UnificationXref
id: F1NUX4
db: uniprot

uniprot Q9WVS8 104
type: UnificationXref
id: Q9WVS8
db: uniprot

PARTICIPANT STOICHIOMETRY r14 590
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 591
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

3-phosphoinositide dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot F1Q2Y3 354
organism: Canis lupus familiaris

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A1D5R9X3 491
xref: PTHR11801:SF18
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r14 592
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 322
xref: PTHR44329:SF22
xref: uniprot P05625 337
organism: Gallus gallus

uniprot P19419 19
type: UnificationXref
id: P19419
db: uniprot

Ets s77 a151 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F1MYE0 291
type: UnificationXref
id: F1MYE0
db: uniprot

uniprot P40189 141
type: UnificationXref
id: P40189
db: uniprot

uniprot A0A2J8LTH4 277
type: UnificationXref
id: A0A2J8LTH4
db: uniprot

Ribosomal protein S6 kinase alpha-2
type: ProteinReference
xref: uniprot Q15349 56
xref: PTHR24351:SF213
organism: Homo sapiens

p21CIP1
type: Protein
entity reference: p21CIP1
feature: p21CIP1 s66 a113 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

MNK1/2
type: Protein
entity reference: MNK1/2
feature: MNK1 2 s81 a148 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_p27KIP1-RIGHT__p27KIP1-_ADP-_r45
controller: PKB

uniprot Q61532 97
type: UnificationXref
id: Q61532
db: uniprot

Ikk s57 a102 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Uncharacterized protein
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot F7DNM3 252
organism: Macaca mulatta

IL13RA1 isoform 1
type: ProteinReference
xref: PTHR23036:SF89
xref: uniprot H2QZ14 433
organism: Pan troglodytes

Interleukin 13 receptor subunit alpha 2
type: ProteinReference
xref: PTHR23036:SF101
xref: uniprot H2QZ11 432
organism: Pan troglodytes

Serum response factor
type: ProteinReference
xref: uniprot P11831 373
xref: PTHR48019:SF40
organism: Homo sapiens

uniprot Q9V3Q6 352
type: UnificationXref
id: Q9V3Q6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1N4K5 475
xref: PTHR45767:SF4
organism: Bos taurus

uniprot P52631 524
type: UnificationXref
id: P52631
db: uniprot

ERK
type: Protein
entity reference: ERK
feature: ERK s93 a137 rs1
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Interleukin-4
type: ProteinReference
xref: uniprot P20096 172
organism: Rattus norvegicus

Interleukin s9 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Interleukin
stoichiometric coefficient: 1.0

uniprot A4GTP4 6
type: UnificationXref
id: A4GTP4
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: c-fos

uniprot P10398 338
type: UnificationXref
id: P10398
db: uniprot

uniprot O09030 434
type: UnificationXref
id: O09030
db: uniprot

STATE_TRANSITION_LEFT__c_fos-RIGHT__c_fos-_r58
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 669
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 668
left: c-fos
interaction type: STATE_TRANSITION
right: c-fos

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot D4A3T0 298
xref: PTHR23113:SF168
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Grb2-_SOS-_Shc-RIGHT__Complex__Grb2_Shc__SOS_-_r19
controller: IRS1/2

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot P0C865 85
type: UnificationXref
id: P0C865
db: uniprot

GSK3 s35 a50 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot G5E577 80
type: UnificationXref
id: G5E577
db: uniprot

Interleukin-23 subunit alpha
type: ProteinReference
xref: PTHR15947:SF0
xref: uniprot Q9NPF7 468
organism: Homo sapiens

Signal transducer and activator of transcription 1-alpha/beta
type: ProteinReference
xref: uniprot P42224 514
xref: PTHR11801:SF18
organism: Homo sapiens

Interleukin
type: ProteinReference
xref: uniprot H2QQ45 157
xref: PTHR14356:SF2
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_STAT-RIGHT__STAT-_ADP-_r68
controller: ERK

MAPK6 isoform 1
type: ProteinReference
xref: uniprot H2Q9G3 81
xref: PTHR24055:SF171
organism: Pan troglodytes

uniprot H2QZ11 432
type: UnificationXref
id: H2QZ11
db: uniprot

uniprot F1N7C3 300
type: UnificationXref
id: F1N7C3
db: uniprot

uniprot H9EPM1 263
type: UnificationXref
id: H9EPM1
db: uniprot

uniprot A0A1D5Q7M2 410
type: UnificationXref
id: A0A1D5Q7M2
db: uniprot

PARTICIPANT STOICHIOMETRY r8 563
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

uniprot Q80Y86 102
type: UnificationXref
id: Q80Y86
db: uniprot

PTHR11849:SF17
type: RelationshipXref
id: PTHR11849:SF17
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r8 562
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

uniprot E2RP04 41
type: UnificationXref
id: E2RP04
db: uniprot

PTHR11849:SF16
type: RelationshipXref
id: PTHR11849:SF16
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r8 561
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription 5B
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot P42232 521
organism: Mus musculus

Signal transducer and activator of transcription 5A
type: ProteinReference
xref: PTHR11801:SF47
xref: uniprot P42230 520
organism: Mus musculus

Interleukin-23 subunit alpha
type: ProteinReference
xref: PTHR15947:SF0
xref: uniprot Q9EQ14 467
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r8 564
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q5F3U4 357
organism: Gallus gallus

uniprot A0A0G2K344 386
type: UnificationXref
id: A0A0G2K344
db: uniprot

Signal transducer and activator of transcription 5A
type: ProteinReference
xref: uniprot P42229 519
xref: PTHR11801:SF47
organism: Homo sapiens

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P42227 517
organism: Mus musculus

Signal transducer and activator of transcription 4
type: ProteinReference
xref: PTHR11801:SF19
xref: uniprot P42228 518
organism: Mus musculus

Signal transducer and activator of transcription 1
type: ProteinReference
xref: uniprot P42225 515
xref: PTHR11801:SF18
organism: Mus musculus

uniprot F7G3I5 397
type: UnificationXref
id: F7G3I5
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot Q8BTI9 405
organism: Mus musculus

Signal transducer and activator of transcription 6
type: ProteinReference
xref: PTHR11801:SF48
xref: uniprot P42226 516
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r10 612
type: Stoichiometry
physical entity: ELK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 611
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot D3ZHH8 367
type: UnificationXref
id: D3ZHH8
db: uniprot

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 324
evidence: Evidence 322
evidence: Evidence 323
evidence: Evidence 321
xref: PTHR44329:SF22
xref: uniprot E2REI6 329
organism: Canis lupus familiaris

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF19
xref: uniprot A0A1D5QTL2 490
organism: Macaca mulatta

Nitric oxide synthase
type: ProteinReference
xref: uniprot F6S3S1 361
xref: PTHR19384:SF66
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r10 614
type: Stoichiometry
physical entity: ELK
stoichiometric coefficient: 1.0

Son of sevenless homolog 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot Q07889 311
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r10 613
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot F6QUW1 303
type: UnificationXref
id: F6QUW1
db: uniprot

Receptor subunit beta
type: ProteinReference
xref: P00974
standard name: Interleukin receptor beta subunit
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.RECEPTOR.Receptor_br_subunit_space__beta_
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
comment: ENTITY_REFERENCE_NOTES=Long Name: Receptor subunit beta Synonym: Synonym not specified Accession: P00974
member entity reference: Interleukin-12 receptor subunit beta-2
member entity reference: C-X-C chemokine receptor type 2
member entity reference: IL10RB isoform 1
member entity reference: Interleukin-2 receptor subunit beta
member entity reference: Interleukin-10 receptor subunit beta
member entity reference: C-X-C chemokine receptor type 2 (Fragment)
member entity reference: Interleukin 12 receptor subunit beta 2
member entity reference: Interleukin 12 receptor subunit beta 1
member entity reference: Cytokine receptor common subunit beta
member entity reference: Uncharacterized protein
member entity reference: IL12RB2 isoform 1
member entity reference: Interleukin-12 receptor subunit beta-1
member entity reference: Interleukin-3 receptor class 2 subunit beta

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF213
xref: uniprot F1M7N7 42
organism: Rattus norvegicus

PTHR11849:SF21
type: RelationshipXref
id: PTHR11849:SF21
db: PANTHER Family
relationship type: By Homology

uniprot H2QR74 254
type: UnificationXref
id: H2QR74
db: uniprot

uniprot E1BCH7 193
type: UnificationXref
id: E1BCH7
db: uniprot

uniprot Q9WUA6 228
type: UnificationXref
id: Q9WUA6
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2R2N2 67
xref: PTHR24055:SF203
organism: Canis lupus familiaris

uniprot F7HN68 379
type: UnificationXref
id: F7HN68
db: uniprot

uniprot Q6P943 531
type: UnificationXref
id: Q6P943
db: uniprot

Interleukin-15 receptor subunit alpha
type: ProteinReference
xref: uniprot Q60819 458
xref: PTHR15060:SF0
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r32
controller: Complex (Receptor subunit alpha/Receptor subunit beta/ Signaling subunit/Interleukin)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P32871 401
xref: PTHR10048:SF107
organism: Bos taurus

uniprot F1PH12 369
type: UnificationXref
id: F1PH12
db: uniprot

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot E2RB53 260
organism: Canis lupus familiaris

Interleukin-4 receptor subunit alpha
type: ProteinReference
xref: uniprot P16382 439
xref: PTHR23037:SF32
organism: Mus musculus

PTHR11801:SF19
type: RelationshipXref
id: PTHR11801:SF19
db: PANTHER Family
relationship type: By Homology

PTHR11801:SF18
type: RelationshipXref
id: PTHR11801:SF18
db: PANTHER Family
relationship type: By Homology

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q60823 227
organism: Mus musculus

PTHR23113:SF168
type: RelationshipXref
id: PTHR23113:SF168
db: PANTHER Family
relationship type: By Homology

uniprot P50904 256
type: UnificationXref
id: P50904
db: uniprot

uniprot Q64385 461
type: UnificationXref
id: Q64385
db: uniprot

STAT
type: ProteinReference
xref: P00996
standard name: Signal transducers and activators of transcription
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.STAT
comment: ENTITY_REFERENCE_NOTES=Long Name: Signal transducers and activators of transcription Synonym: STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,family members include STAT1 Accession: P00996
member entity reference: Signal transducer and activator of transcription
member entity reference: Signal transducer and activator of transcription 5B
member entity reference: Signal transducer and activator of transcription 1-alpha/beta
member entity reference: Signal transducer and activator of transcription 4
member entity reference: Signal transducer and activator of transcription 2
member entity reference: Signal transducer and transcription activator 6
member entity reference: Signal transducer and activator of transcription 5A
member entity reference: Signal transducer and activator of transcription 6
member entity reference: Signal transducer and activator of transcription 1
member entity reference: Signal transducer and activator of transcription 3

Uncharacterized protein
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F6YCI3 305
organism: Monodelphis domestica

PTHR24349:SF63
type: RelationshipXref
id: PTHR24349:SF63
db: PANTHER Family
relationship type: By Homology

PTHR46778:SF1
type: RelationshipXref
id: PTHR46778:SF1
db: PANTHER Family
relationship type: By Homology

Interleukin-12 receptor subunit beta-1
type: ProteinReference
xref: uniprot Q60837 247
organism: Mus musculus

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot P12841 124
organism: Rattus norvegicus

PTHR15060:SF0
type: RelationshipXref
id: PTHR15060:SF0
db: PANTHER Family
relationship type: By Homology

eNOS
type: Protein
entity reference: eNOS
feature: eNOS s55 a100 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q91Z84 464
type: UnificationXref
id: Q91Z84
db: uniprot

Glycogen synthase kinase-3 beta isoform 1
type: ProteinReference
xref: uniprot H9EPM1 263
xref: PTHR24057:SF8
organism: Macaca mulatta

uniprot Q61727 459
type: UnificationXref
id: Q61727
db: uniprot

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PR50 349
organism: Macaca mulatta

STAT s113 a173 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

p90RSK s84 a144 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR11801:SF39
type: RelationshipXref
id: PTHR11801:SF39
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__ATP-_Ikk-RIGHT__Ikk-_ADP-_r40
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 627
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 628
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 630
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 629
left: Ikk
left: ATP
interaction type: STATE_TRANSITION
right: Ikk
right: ADP

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P14056 341
xref: PTHR44329:SF55
organism: Rattus norvegicus

uniprot A0A1D5QTL2 490
type: UnificationXref
id: A0A1D5QTL2
db: uniprot

uniprot D4A4I9 149
type: UnificationXref
id: D4A4I9
db: uniprot

uniprot E2R2L2 109
type: UnificationXref
id: E2R2L2
db: uniprot

PDK1/2
type: Protein
entity reference: PDK1/2
feature: PDK1 2 s32 a47 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r58 669
type: Stoichiometry
physical entity: c-fos
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 668
type: Stoichiometry
physical entity: c-fos
stoichiometric coefficient: 1.0

uniprot P05231 164
type: UnificationXref
id: P05231
db: uniprot

C-X-C chemokine receptor type 2 (Fragment)
type: ProteinReference
xref: uniprot Q28807 246
xref: PTHR10489:SF689
organism: Pan troglodytes

PTHR11801:SF41
type: RelationshipXref
id: PTHR11801:SF41
db: PANTHER Family
relationship type: By Homology

p27KIP1 s122 a114 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR11801:SF47
type: RelationshipXref
id: PTHR11801:SF47
db: PANTHER Family
relationship type: By Homology

uniprot Q9BUB5 203
type: UnificationXref
id: Q9BUB5
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot P08556 274
xref: PTHR24070:SF189
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_IRS1_2-RIGHT__ADP-_IRS1_2-_r16
controller: Src-like

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6QE96 215
xref: PTHR24356:SF176
organism: Macaca mulatta

uniprot F6V2H6 72
type: UnificationXref
id: F6V2H6
db: uniprot

uniprot Q7ZVK8 101
type: UnificationXref
id: Q7ZVK8
db: uniprot

Interleukin-13 receptor subunit alpha-2
type: ProteinReference
xref: PTHR23036:SF101
xref: uniprot O88786 435
organism: Mus musculus

Ribosomal protein S6 kinase alpha-2
type: ProteinReference
xref: uniprot Q9WUT3 61
xref: PTHR24351:SF213
organism: Mus musculus

uniprot F7AR90 420
type: UnificationXref
id: F7AR90
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F1PRG4 213
organism: Canis lupus familiaris

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F6UNV6 43
xref: PTHR24351:SF58
organism: Macaca mulatta

PTHR45767:SF4
type: RelationshipXref
id: PTHR45767:SF4
db: PANTHER Family
relationship type: By Homology

ETS domain-containing protein Elk-4
type: ProteinReference
xref: PTHR11849:SF21
xref: uniprot P28324 22
organism: Homo sapiens

uniprot H2RA86 83
type: UnificationXref
id: H2RA86
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: ELK

PTHR11801:SF2
type: RelationshipXref
id: PTHR11801:SF2
db: PANTHER Family
relationship type: By Homology

Ras GTPase-activating protein 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot F1N7N8 251
organism: Bos taurus

Ets
type: ProteinReference
xref: P00989
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.Ets
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Ets Synonym: Synonym not specified Accession: P00989
member entity reference: SPIB
member entity reference: Spi-C transcription factor
member entity reference: Uncharacterized protein
member entity reference: Transcription factor PU.1
member entity reference: Transcription factor Spi-C
member entity reference: Spi-1 proto-oncogene
member entity reference: Uncharacterized protein (Fragment)

uniprot F6VXG1 392
type: UnificationXref
id: F6VXG1
db: uniprot

Interleukin-23 subunit alpha
type: ProteinReference
xref: uniprot Q91Z84 464
organism: Rattus norvegicus

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot E2RB82 495
organism: Canis lupus familiaris

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: uniprot Q9WV60 266
xref: PTHR24057:SF8
organism: Mus musculus

uniprot Q15349 56
type: UnificationXref
id: Q15349
db: uniprot

uniprot P41970 27
type: UnificationXref
id: P41970
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P10398 338
xref: PTHR44329:SF55
organism: Homo sapiens

PTHR10489:SF689
type: RelationshipXref
id: PTHR10489:SF689
db: PANTHER Family
relationship type: By Homology

uniprot O93599 512
type: UnificationXref
id: O93599
db: uniprot

c-Myc
type: Protein
entity reference: c-Myc
feature: c Myc s76 a150 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5ZMM7 29
organism: Gallus gallus

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF43
xref: uniprot A0A3Q1MLN6 38
organism: Bos taurus

uniprot Q13164 92
type: UnificationXref
id: Q13164
db: uniprot

uniprot P42225 515
type: UnificationXref
id: P42225
db: uniprot

Ribosomal protein S6 kinase alpha-3
type: ProteinReference
xref: uniprot P18654 54
xref: PTHR24351:SF58
organism: Mus musculus

Cyclin-dependent kinase inhibitor 1
type: ProteinReference
xref: PTHR46778:SF1
xref: uniprot P39689 472
organism: Mus musculus

Ribosomal protein S6 kinase alpha-1
type: ProteinReference
xref: uniprot P18653 52
xref: PTHR24351:SF43
organism: Mus musculus

Ribosomal protein S6 kinase 2 alpha
type: ProteinReference
xref: uniprot P18652 51
xref: PTHR24351:SF43
organism: Gallus gallus

uniprot Q9YH60 267
type: UnificationXref
id: Q9YH60
db: uniprot

Signal transducer and activator of transcription 2
type: ProteinReference
xref: uniprot P52630 523
organism: Homo sapiens

uniprot H2QNG6 399
type: UnificationXref
id: H2QNG6
db: uniprot

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: uniprot P18266 264
xref: PTHR24057:SF8
organism: Rattus norvegicus

PIP2
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P22272 441
type: UnificationXref
id: P22272
db: uniprot

uniprot Q6DV79 530
type: UnificationXref
id: Q6DV79
db: uniprot

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot Q6DV79 530
organism: Gallus gallus

ncbitaxon 9598 18
type: UnificationXref
id: 9598
db: ncbitaxon

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P52631 524
organism: Rattus norvegicus

Signal transducer and activator of transcription 5B
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot P52632 525
organism: Rattus norvegicus

Signal transducer and transcription activator 6
type: ProteinReference
xref: PTHR11801:SF48
xref: uniprot P52633 526
organism: Mus musculus

uniprot P16297 238
type: UnificationXref
id: P16297
db: uniprot

Interleukin
type: ProteinReference
xref: P00970
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.Interleukin
comment: ENTITY_REFERENCE_NOTES=Long Name: Interleukin Synonym: Synonym not specified Accession: P00970
member entity reference: Interleukin-11
member entity reference: Multifunctional fusion protein
member entity reference: Pro-interleukin-16
member entity reference: Interleukin-1 alpha
member entity reference: Interleukin-15
member entity reference: Interleukin-8
member entity reference: Interleukin-6
member entity reference: Interleukin-1
member entity reference: Interleukin 11
member entity reference: Interleukin-4
member entity reference: Interleukin
member entity reference: Interleukin-21
member entity reference: Interleukin-9
member entity reference: IL9 isoform 1
member entity reference: IL11 isoform 1
member entity reference: Interleukin 6

PIP3
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A2I3T649 415
type: UnificationXref
id: A0A2I3T649
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot F7BYN4 505
organism: Monodelphis domestica

uniprot A0A2I3T2I1 376
type: UnificationXref
id: A0A2I3T2I1
db: uniprot

IDA
type: EvidenceCodeVocabulary

uniprot F1P859 301
type: UnificationXref
id: F1P859
db: uniprot

SLA2 isoform 1
type: ProteinReference
xref: PTHR10155:SF6
xref: uniprot H2QKA6 408
organism: Pan troglodytes

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F1N7C3 300
organism: Bos taurus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63085 90
xref: PTHR24055:SF203
organism: Mus musculus

C-X-C chemokine receptor type 1
type: ProteinReference
xref: uniprot P25024 444
xref: PTHR10489:SF916
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r43 609
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

C-X-C chemokine receptor type 2
type: ProteinReference
xref: PTHR10489:SF689
xref: uniprot P25025 239
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r43 608
type: Stoichiometry
physical entity: mTOR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r43 607
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63086 91
xref: PTHR24055:SF203
organism: Rattus norvegicus

uniprot Q15418 57
type: UnificationXref
id: Q15418
db: uniprot

uniprot P42346 115
type: UnificationXref
id: P42346
db: uniprot

p21CIP1 s120 a110 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P28324 22
type: UnificationXref
id: P28324
db: uniprot

Ras
type: ProteinReference
xref: P00977
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Ras Synonym: Synonym not specified Accession: P00977
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.Ras
member entity reference: GTPase NRas
member entity reference: NRAS proto-oncogene, GTPase
member entity reference: NRAS protein
member entity reference: NRAS isoform 1

Raf
type: Protein
entity reference: Raf
feature: Raf s22 a32 rs1
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Interleukin-11 receptor subunit alpha-1
type: ProteinReference
xref: uniprot Q64385 461
xref: PTHR23036:SF29
organism: Mus musculus

uniprot F6Z890 419
type: UnificationXref
id: F6Z890
db: uniprot

uniprot P01109 484
type: UnificationXref
id: P01109
db: uniprot

PTHR10614:SF7
type: RelationshipXref
id: PTHR10614:SF7
db: PANTHER Family
relationship type: By Homology

uniprot P38936 471
type: UnificationXref
id: P38936
db: uniprot

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__ATP-_MAPKAPK2-RIGHT__ADP-_MAPKAPK2-_r53
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 683
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 682
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 685
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 684
left: MAPKAPK2
left: ATP
interaction type: STATE_TRANSITION
right: MAPKAPK2
right: ADP

Uncharacterized protein
type: ProteinReference
evidence: Evidence 324
evidence: Evidence 322
evidence: Evidence 323
evidence: Evidence 321
xref: PTHR44329:SF22
xref: uniprot F7BRK5 331
organism: Monodelphis domestica

Son of sevenless homolog 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot Q62245 313
organism: Mus musculus

PTHR23037:SF32
type: RelationshipXref
id: PTHR23037:SF32
db: PANTHER Family
relationship type: By Homology

uniprot P42336 402
type: UnificationXref
id: P42336
db: uniprot

uniprot Q5M824 542
type: UnificationXref
id: Q5M824
db: uniprot

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot Q9QY78 138
organism: Rattus norvegicus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A2I3TNY5 492
xref: PTHR11801:SF18
organism: Pan troglodytes

uniprot F7EGQ8 153
type: UnificationXref
id: F7EGQ8
db: uniprot

uniprot Q62245 313
type: UnificationXref
id: Q62245
db: uniprot

Jak
type: Protein
entity reference: Jak
feature: Jak s104 a12 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Jak s125 a222 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.04
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY r43 610
type: Stoichiometry
physical entity: mTOR
stoichiometric coefficient: 1.0

uniprot Q60823 227
type: UnificationXref
id: Q60823
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot W4Y0P1 268
organism: Strongylocentrotus purpuratus

Interleukin-4
type: ProteinReference
xref: uniprot P05112 163
organism: Homo sapiens

Interleukin-10 receptor subunit beta
type: ProteinReference
xref: PTHR20859:SF50
xref: uniprot Q61190 248
organism: Mus musculus

By Homology
type: RelationshipTypeVocabulary

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Src_like-RIGHT__ADP-_Src_like-_r18
controller: Complex (Receptor subunit alpha/Receptor subunit beta/ Signaling subunit/Interleukin)

uniprot F6PR50 349
type: UnificationXref
id: F6PR50
db: uniprot

STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_r59
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 667
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 666
left: SRF
interaction type: STATE_TRANSITION
right: SRF

uniprot A0A1D5Q5Z6 62
type: UnificationXref
id: A0A1D5Q5Z6
db: uniprot

Myc proto-oncogene protein
type: ProteinReference
xref: PTHR45851:SF1
xref: uniprot F1PW15 481
organism: Canis lupus familiaris

TRANSPORT_LEFT__p90RSK-RIGHT__p90RSK-_r56
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 673
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 672
left: p90RSK
interaction type: TRANSPORT
right: p90RSK

uniprot F6YCI3 305
type: UnificationXref
id: F6YCI3
db: uniprot

Insulin receptor substrate 2
type: ProteinReference
xref: PTHR10614:SF7
xref: uniprot F7DE94 292
organism: Macaca mulatta

uniprot P29474 363
type: UnificationXref
id: P29474
db: uniprot

uniprot A0A3Q1LXK8 37
type: UnificationXref
id: A0A3Q1LXK8
db: uniprot

uniprot A0A1D5NUC4 348
type: UnificationXref
id: A0A1D5NUC4
db: uniprot

uniprot F1N7N8 251
type: UnificationXref
id: F1N7N8
db: uniprot

PTHR11801:SF48
type: RelationshipXref
id: PTHR11801:SF48
db: PANTHER Family
relationship type: By Homology

uniprot P15056 342
type: UnificationXref
id: P15056
db: uniprot

PTHR23037:SF22
type: RelationshipXref
id: PTHR23037:SF22
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot A0A0G2K344 386
xref: PTHR10048:SF107
organism: Rattus norvegicus

uniprot F6YJ34 47
type: UnificationXref
id: F6YJ34
db: uniprot

uniprot A6QLS3 314
type: UnificationXref
id: A6QLS3
db: uniprot

uniprot P01589 436
type: UnificationXref
id: P01589
db: uniprot

uniprot A0A2I3TRE4 494
type: UnificationXref
id: A0A2I3TRE4
db: uniprot

Interleukin-4 receptor subunit alpha
type: ProteinReference
xref: uniprot P24394 443
xref: PTHR23037:SF32
organism: Homo sapiens

Interleukin-8
type: ProteinReference
xref: PTHR10179:SF42
xref: uniprot P67813 185
organism: Macaca mulatta

p27KIP1
type: ProteinReference
xref: P00982
standard name: Cyclin-dependent kinase inhibitor 1B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Cyclin-dependent kinase inhibitor 1B Synonym: CDKN1B,p27,p27KIP1 Accession: P00982
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.p27KIP1
member entity reference: Cyclin-dependent kinase inhibitor 1B
member entity reference: Cyclin dependent kinase inhibitor
member entity reference: CDKN1B protein
member entity reference: CDKN1B isoform 1

Receptor subunit beta s4 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Receptor subunit beta
stoichiometric coefficient: 1.0

PTHR23037:SF30
type: RelationshipXref
id: PTHR23037:SF30
db: PANTHER Family
relationship type: By Homology

uniprot F6WBW6 73
type: UnificationXref
id: F6WBW6
db: uniprot

Signal transducer and activator of transcription 5A
type: ProteinReference
xref: uniprot Q95115 532
xref: PTHR11801:SF47
organism: Bos taurus

uniprot Q99MF4 466
type: UnificationXref
id: Q99MF4
db: uniprot

uniprot F7BA89 111
type: UnificationXref
id: F7BA89
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F1Q3M8 390
xref: PTHR10048:SF107
organism: Canis lupus familiaris

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot H9FVU5 400
organism: Macaca mulatta

PTHR23113:SF150
type: RelationshipXref
id: PTHR23113:SF150
db: PANTHER Family
relationship type: By Homology

uniprot O15530 355
type: UnificationXref
id: O15530
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ERK-_ATP-RIGHT__ADP-_ERK-_r9
controller: MEK

ncbitaxon 9615 13
type: UnificationXref
id: 9615
db: ncbitaxon

PTHR47401:SF1
type: RelationshipXref
id: PTHR47401:SF1
db: PANTHER Family
relationship type: By Homology

CDKN1B isoform 1
type: ProteinReference
xref: uniprot H2Q5H2 316
organism: Pan troglodytes

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

IL10RA isoform 2
type: ProteinReference
xref: PTHR20859:SF43
xref: uniprot A0A2I3T649 415
organism: Pan troglodytes

uniprot A5A6H0 117
type: UnificationXref
id: A5A6H0
db: uniprot

uniprot E2RL20 330
type: UnificationXref
id: E2RL20
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MNK1_2-_ATP-RIGHT__ADP-_MNK1_2-_r51
controller: ERK

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F6Y841 393
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r46 594
type: Stoichiometry
physical entity: p21CIP1
stoichiometric coefficient: 1.0

ncbitaxon 8364 77
type: UnificationXref
id: 8364
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r46 593
type: Stoichiometry
physical entity: p21CIP1
stoichiometric coefficient: 1.0

uniprot Q9Z2A0 358
type: UnificationXref
id: Q9Z2A0
db: uniprot

STAT
type: Protein
entity reference: STAT
feature: STAT s115 a175 rs1
feature: STAT s115 a175 rs2
feature: ACTIVE 31

uniprot K7CZM1 309
type: UnificationXref
id: K7CZM1
db: uniprot

uniprot H9EP11 196
type: UnificationXref
id: H9EP11
db: uniprot

Interleukin-6
type: ProteinReference
xref: uniprot P08505 166
xref: PTHR10511:SF3
organism: Mus musculus

uniprot P04627 336
type: UnificationXref
id: P04627
db: uniprot

Evidence 324
type: Evidence
evidence code: ISS
comment: SPACC Q99N57

Evidence 323
type: Evidence
evidence code: ISS
comment: SPACC P11345

ETS domain-containing protein Elk-4 isoform a
type: ProteinReference
xref: PTHR11849:SF21
xref: uniprot F6XTS0 14
organism: Macaca mulatta

uniprot A0A0G2K3R1 347
type: UnificationXref
id: A0A0G2K3R1
db: uniprot

Evidence 322
type: Evidence
evidence code: ISS
comment: SPACC P05625

Evidence 321
type: Evidence
evidence code: ISS
comment: SPACC P04049

Interleukin-4 receptor subunit alpha
type: ProteinReference
xref: PTHR23037:SF32
xref: uniprot Q63257 460
organism: Rattus norvegicus

Interleukin-2 receptor subunit alpha
type: ProteinReference
xref: uniprot Q5MNY4 457
xref: PTHR10573:SF0
organism: Macaca mulatta

uniprot F1LRH7 230
type: UnificationXref
id: F1LRH7
db: uniprot

uniprot E9PYG6 250
type: UnificationXref
id: E9PYG6
db: uniprot

ERK s27 a36 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6SW23 391
xref: PTHR10048:SF107
organism: Gallus gallus

Interleukin-10 receptor subunit beta
type: ProteinReference
xref: uniprot Q08334 244
organism: Homo sapiens

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot F7BQ11 504
organism: Gallus gallus

SOS s17 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

uniprot P42224 514
type: UnificationXref
id: P42224
db: uniprot

STATE_TRANSITION_LEFT__p90RSK-_ATP-RIGHT__ADP-_p90RSK-_r52
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 687
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 686
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 689
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 688
left: p90RSK
left: ATP
interaction type: STATE_TRANSITION
right: p90RSK
right: ADP

uniprot P40933 177
type: UnificationXref
id: P40933
db: uniprot

Interleukin-4
type: ProteinReference
xref: PTHR47401:SF1
xref: uniprot O77762 160
organism: Canis lupus familiaris

uniprot P52333 279
type: UnificationXref
id: P52333
db: uniprot

Interleukin-15
type: ProteinReference
xref: PTHR14356:SF3
xref: uniprot P48092 181
organism: Macaca mulatta

Interleukin 5 receptor subunit alpha
type: ProteinReference
xref: PTHR23036:SF17
xref: uniprot H2QLZ0 431
organism: Pan troglodytes

Cyclin-dependent kinase inhibitor 1
type: ProteinReference
xref: uniprot P38936 471
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r34 660
type: Stoichiometry
physical entity: PDK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r34 661
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q02384 310
type: UnificationXref
id: Q02384
db: uniprot

SHC-transforming protein 1
type: ProteinReference
xref: uniprot Q5M824 542
xref: PTHR10337:SF2
organism: Rattus norvegicus

uniprot A0A3Q1M353 327
type: UnificationXref
id: A0A3Q1M353
db: uniprot

STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_Pi-_r14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 591
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 592
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 590
left: Ras
interaction type: STATE_TRANSITION
right: Pi
right: Ras

Ets s87 a139 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Cyclin-dependent kinase inhibitor 1B
type: ProteinReference
xref: uniprot F1PGU6 315
xref: PTHR10265:SF9
organism: Canis lupus familiaris

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q7ZVK8 101
organism: Danio rerio

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F6URW3 304
organism: Ornithorhynchus anatinus

uniprot H2QKA6 408
type: UnificationXref
id: H2QKA6
db: uniprot

Evidence 346
type: Evidence
evidence code: IGI
comment: SPACC Q99N57

PARTICIPANT STOICHIOMETRY r34 659
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 60

uniprot Q9Z2A6 106
type: UnificationXref
id: Q9Z2A6
db: uniprot

uniprot H2QQ45 157
type: UnificationXref
id: H2QQ45
db: uniprot

uniprot Q561K3 456
type: UnificationXref
id: Q561K3
db: uniprot

MEK s26 a35 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Evidence 340
type: Evidence
evidence code: IGI
comment: SPACC P11345

Interleukin-1 alpha
type: ProteinReference
xref: PTHR10078:SF33
xref: uniprot P48089 180
organism: Macaca mulatta

uniprot H2QZ14 433
type: UnificationXref
id: H2QZ14
db: uniprot

uniprot Q9EQ14 467
type: UnificationXref
id: Q9EQ14
db: uniprot

PARTICIPANT STOICHIOMETRY r34 658
type: Stoichiometry
physical entity: PDK1/2
stoichiometric coefficient: 1.0

PDK1 2 s33 a48 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Ras GTPase-activating protein 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot P50904 256
organism: Rattus norvegicus

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: uniprot Q66JF3 201
organism: Xenopus tropicalis

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF213
xref: uniprot F6UWI0 44
organism: Canis lupus familiaris

uniprot Q9Y243 229
type: UnificationXref
id: Q9Y243
db: uniprot

uniprot P11345 339
type: UnificationXref
id: P11345
db: uniprot

Evidence 335
type: Evidence
evidence code: TAS
comment: SPACC P04049

Complex (Grb2/Shc/ SOS)
type: Complex
component stoichiometry: Shc s16 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Grb2 s15 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS s17 sa3 STOICHIOMETRY ID COMPLEX
component: SOS
component: Grb2
component: Shc
feature: COMPLEX BINDING FEATURE s132 a73 551
feature: COMPLEX BINDING FEATURE s132 a73 555
feature: COMPLEX BINDING FEATURE s132 a73 553
cellular location: cytoplasm

uniprot Q07890 312
type: UnificationXref
id: Q07890
db: uniprot

Evidence 334
type: Evidence
evidence code: IC
comment: SPACC P04049

uniprot P31751 224
type: UnificationXref
id: P31751
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QF27 411
organism: Macaca mulatta

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: uniprot F7ACT4 262
xref: PTHR24057:SF8
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot A0A3Q2TVV5 258
organism: Gallus gallus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q6P023 99
xref: PTHR24055:SF203
organism: Danio rerio

MAP kinase interacting serine/threonine kinase 2
type: ProteinReference
xref: uniprot E1BCH7 193
xref: PTHR24349:SF254
organism: Bos taurus

SHC-transforming protein 1
type: ProteinReference
xref: uniprot P29353 539
xref: PTHR10337:SF2
organism: Homo sapiens

uniprot H9FYU7 308
type: UnificationXref
id: H9FYU7
db: uniprot

ELK
type: ProteinReference
xref: P00962
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: ELK Synonym: Synonym not specified Accession: P00962
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.ELK
member entity reference: ELK4, ETS transcription factor
member entity reference: ELK3, ETS transcription factor
member entity reference: Uncharacterized protein
member entity reference: ETS domain-containing protein Elk-3
member entity reference: ETS domain-containing protein Elk-4
member entity reference: ETS domain-containing protein Elk-1
member entity reference: ETS domain-containing protein Elk-4 isoform a
member entity reference: ELK3 isoform 1
member entity reference: ELK3, ETS-domain protein (SRF accessory protein 2)

uniprot P70313 364
type: UnificationXref
id: P70313
db: uniprot

Interleukin 11
type: ProteinReference
xref: uniprot F1PPR5 151
organism: Canis lupus familiaris

uniprot A0A3Q2UBK0 39
type: UnificationXref
id: A0A3Q2UBK0
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot A0A2I3TQ88 493
organism: Pan troglodytes

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 77

Raf
type: Protein
entity reference: Raf
feature: Raf s22 a30 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot O54824 159
type: UnificationXref
id: O54824
db: uniprot

uniprot P01106 482
type: UnificationXref
id: P01106
db: uniprot

Interleukin 15 receptor subunit alpha
type: ProteinReference
xref: uniprot A0A2I3SCX4 413
organism: Pan troglodytes

PTHR45851:SF1
type: RelationshipXref
id: PTHR45851:SF1
db: PANTHER Family
relationship type: By Homology

uniprot F7F772 16
type: UnificationXref
id: F7F772
db: uniprot

Complex (Receptor subunit alpha/Receptor subunit beta/ Signaling subunit/Interleukin)
type: Complex
component stoichiometry: Receptor subunit beta s4 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Interleukin s9 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: Receptor subunit alpha s1 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: Signaling subunit s6 sa6 STOICHIOMETRY ID COMPLEX
component: Interleukin
component: Signaling subunit
component: Receptor subunit alpha
component: Receptor subunit beta
feature: COMPLEX BINDING FEATURE s119 a182 547
feature: COMPLEX BINDING FEATURE s119 a182 545
feature: COMPLEX BINDING FEATURE s119 a182 549
feature: COMPLEX BINDING FEATURE s119 a182 543
cellular location: cytoplasm

FKHRL1
type: ProteinReference
xref: P00994
standard name: Forkhead in Rhabdomyosarcoma-like 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Forkhead in Rhabdomyosarcoma-like 1 Synonym: FKHRL1,FOXO3A Accession: P00994
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.FKHRL1
member entity reference: Uncharacterized protein
member entity reference: Forkhead box O3
member entity reference: FOXO3 isoform 1
member entity reference: Forkhead box protein O3

p90RSK
type: Protein
entity reference: p90RSK
feature: p90RSK s80 a147 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Interleukin-1 alpha
type: ProteinReference
xref: uniprot P08831 167
xref: PTHR10078:SF33
organism: Bos taurus

Ikk
type: Protein
entity reference: Ikk
feature: Ikk s57 a102 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r32
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 665
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 664
left: PI3K
interaction type: STATE_TRANSITION
right: PI3K

uniprot P24394 443
type: UnificationXref
id: P24394
db: uniprot

uniprot E1BEL4 278
type: UnificationXref
id: E1BEL4
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot A0A2I3T7A8 388
xref: PTHR10048:SF107
organism: Pan troglodytes

Cyclin-dependent kinase inhibitor 1
type: ProteinReference
xref: uniprot F7EEK4 470
organism: Macaca mulatta

ELK
type: Protein
entity reference: ELK
feature: ELK s31 a44 rs1
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

GSK3
type: ProteinReference
xref: P00976
standard name: Glycogen synthase kinase 3
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.GSK3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Glycogen synthase kinase 3 Synonym: GSK3 Accession: P00976
member entity reference: Glycogen synthase kinase-3 beta
member entity reference: Uncharacterized protein
member entity reference: Glycogen synthase kinase 3 beta
member entity reference: Glycogen synthase kinase 3
member entity reference: Si:dkeyp-80c12.7
member entity reference: Glycogen synthase kinase-3 beta isoform 1

uniprot Q95LF0 465
type: UnificationXref
id: Q95LF0
db: uniprot

uniprot H2QD19 510
type: UnificationXref
id: H2QD19
db: uniprot

uniprot A0A2I3RK51 139
type: UnificationXref
id: A0A2I3RK51
db: uniprot

uniprot P26954 240
type: UnificationXref
id: P26954
db: uniprot

uniprot F6R8N9 70
type: UnificationXref
id: F6R8N9
db: uniprot

uniprot H2Q5H2 316
type: UnificationXref
id: H2Q5H2
db: uniprot

Signaling subunit s6 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Signaling subunit
stoichiometric coefficient: 1.0

uniprot F6XTS0 14
type: UnificationXref
id: F6XTS0
db: uniprot

Fos proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot E2QYK5 119
organism: Canis lupus familiaris

uniprot Q08334 244
type: UnificationXref
id: Q08334
db: uniprot

uniprot Q5MNY4 457
type: UnificationXref
id: Q5MNY4
db: uniprot

uniprot F1Q4F8 214
type: UnificationXref
id: F1Q4F8
db: uniprot

Interleukin-6 receptor subunit beta
type: ProteinReference
xref: PTHR23036:SF83
xref: uniprot P40189 141
organism: Homo sapiens

Interleukin-4
type: ProteinReference
xref: uniprot P07750 165
organism: Mus musculus

Nitric oxide synthase, endothelial
type: ProteinReference
xref: uniprot Q62600 365
xref: PTHR19384:SF66
organism: Rattus norvegicus

p27KIP1 s71 a111 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SRF isoform 1
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot K7D2P2 372
organism: Pan troglodytes

STATE_TRANSITION_LEFT__ATP-_FKHRL1-RIGHT__FKHRL1-_ADP-_r42
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 618
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 617
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 616
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 615
left: FKHRL1
left: ATP
interaction type: STATE_TRANSITION
right: FKHRL1
right: ADP

Insulin receptor substrate 1
type: ProteinReference
xref: uniprot E2RDB5 290
xref: PTHR10614:SF11
organism: Canis lupus familiaris

MAPKAPK2 s95 a153 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR24057:SF0
type: RelationshipXref
id: PTHR24057:SF0
db: PANTHER Family
relationship type: By Homology

Interleukin-6 receptor subunit alpha
type: ProteinReference
xref: uniprot P08887 438
organism: Homo sapiens

PTHR24057:SF8
type: RelationshipXref
id: PTHR24057:SF8
db: PANTHER Family
relationship type: By Homology

uniprot P42228 518
type: UnificationXref
id: P42228
db: uniprot

uniprot Q95115 532
type: UnificationXref
id: Q95115
db: uniprot

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P31751 224
organism: Homo sapiens

BAD s61 a99 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31750 223
organism: Mus musculus

Bos taurus
type: BioSource
xref: ncbitaxon 9913 5

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q9WUA6 228
xref: PTHR24356:SF190
organism: Mus musculus

MAP kinase-activated protein kinase 2
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot P49138 288
organism: Mus musculus

MAP kinase-activated protein kinase 2
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot P49137 287
organism: Homo sapiens

uniprot F7DE94 292
type: UnificationXref
id: F7DE94
db: uniprot

uniprot F1PHV7 271
type: UnificationXref
id: F1PHV7
db: uniprot

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31749 222
organism: Homo sapiens

uniprot E2R2N2 67
type: UnificationXref
id: E2R2N2
db: uniprot

uniprot Q90YI0 189
type: UnificationXref
id: Q90YI0
db: uniprot

uniprot P12841 124
type: UnificationXref
id: P12841
db: uniprot

Interleukin-2 receptor subunit alpha
type: ProteinReference
xref: PTHR10573:SF0
xref: uniprot P01589 436
organism: Homo sapiens

Interleukin-1 alpha
type: ProteinReference
xref: PTHR10078:SF33
xref: uniprot P01583 162
organism: Homo sapiens

uniprot Q62600 365
type: UnificationXref
id: Q62600
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF43
xref: uniprot A0A2I3TPM9 35
organism: Pan troglodytes

Interleukin-1 alpha
type: ProteinReference
xref: PTHR10078:SF33
xref: uniprot P01582 161
organism: Mus musculus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot H2QD19 510
xref: PTHR11801:SF47
organism: Pan troglodytes

uniprot P25024 444
type: UnificationXref
id: P25024
db: uniprot

STAT s116 a176 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.870260612568485
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Mitogen-activated protein kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot F1PZ82 283
organism: Canis lupus familiaris

uniprot F1PRG4 213
type: UnificationXref
id: F1PRG4
db: uniprot

PTHR15947:SF0
type: RelationshipXref
id: PTHR15947:SF0
db: PANTHER Family
relationship type: By Homology

Interleukin-2 receptor subunit alpha
type: ProteinReference
xref: PTHR10573:SF0
xref: uniprot P01590 437
organism: Mus musculus

Interleukin
type: ProteinReference
xref: PTHR14356:SF3
xref: uniprot A0A2I3RU68 147
organism: Pan troglodytes

STAT s116 a176 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r40 630
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot F6UMM2 503
type: UnificationXref
id: F6UMM2
db: uniprot

uniprot P46527 319
type: UnificationXref
id: P46527
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 30

uniprot F6U298 350
type: UnificationXref
id: F6U298
db: uniprot

uniprot F1MAI3 299
type: UnificationXref
id: F1MAI3
db: uniprot

uniprot Q13651 451
type: UnificationXref
id: Q13651
db: uniprot

Serum response factor
type: ProteinReference
xref: uniprot F1PH12 369
xref: PTHR48019:SF40
organism: Canis lupus familiaris

uniprot F1PAY3 499
type: UnificationXref
id: F1PAY3
db: uniprot

uniprot P67813 185
type: UnificationXref
id: P67813
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot H9FU32 332
xref: PTHR44329:SF55
organism: Macaca mulatta

uniprot P01583 162
type: UnificationXref
id: P01583
db: uniprot

PTHR14356:SF2
type: RelationshipXref
id: PTHR14356:SF2
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r40 628
type: Stoichiometry
physical entity: Ikk
stoichiometric coefficient: 1.0

PTHR14356:SF3
type: RelationshipXref
id: PTHR14356:SF3
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r40 627
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r40 629
type: Stoichiometry
physical entity: Ikk
stoichiometric coefficient: 1.0

P00997
type: UnificationXref
id: P00997
db: PANTHER Pathway Component

P00996
type: UnificationXref
id: P00996
db: PANTHER Pathway Component

P00995
type: UnificationXref
id: P00995
db: PANTHER Pathway Component

P00994
type: UnificationXref
id: P00994
db: PANTHER Pathway Component

uniprot P25025 239
type: UnificationXref
id: P25025
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10614:SF11
xref: uniprot A0A1D5QB09 289
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot K7CEN2 84
xref: PTHR24055:SF356
organism: Pan troglodytes

uniprot F6S3S1 361
type: UnificationXref
id: F6S3S1
db: uniprot

uniprot F6UMX8 476
type: UnificationXref
id: F6UMX8
db: uniprot

P00990
type: UnificationXref
id: P00990
db: PANTHER Pathway Component

P00991
type: UnificationXref
id: P00991
db: PANTHER Pathway Component

P00992
type: UnificationXref
id: P00992
db: PANTHER Pathway Component

P00993
type: UnificationXref
id: P00993
db: PANTHER Pathway Component

uniprot A0A3Q2TVV5 258
type: UnificationXref
id: A0A3Q2TVV5
db: uniprot

Ribosomal protein S6 kinase alpha-1
type: ProteinReference
xref: uniprot Q15418 57
xref: PTHR24351:SF43
organism: Homo sapiens

P00987
type: UnificationXref
id: P00987
db: PANTHER Pathway Component

P00989
type: UnificationXref
id: P00989
db: PANTHER Pathway Component

GTPase NRas
type: ProteinReference
xref: uniprot Q5F352 276
xref: PTHR24070:SF189
organism: Gallus gallus

P00984
type: UnificationXref
id: P00984
db: PANTHER Pathway Component

P00983
type: UnificationXref
id: P00983
db: PANTHER Pathway Component

uniprot F1PZ82 283
type: UnificationXref
id: F1PZ82
db: uniprot

P00986
type: UnificationXref
id: P00986
db: PANTHER Pathway Component

P00985
type: UnificationXref
id: P00985
db: PANTHER Pathway Component

Son of sevenless homolog 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot Q02384 310
organism: Mus musculus

ncbitaxon 7955 100
type: UnificationXref
id: 7955
db: ncbitaxon

mTOR
type: Protein
entity reference: mTOR
feature: mTOR s58 a103 rs1
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot H2QVM2 362
type: UnificationXref
id: H2QVM2
db: uniprot

uniprot F6QP11 216
type: UnificationXref
id: F6QP11
db: uniprot

Interleukin-20 receptor subunit alpha
type: ProteinReference
xref: uniprot Q6PHB0 462
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_STAT-RIGHT__STAT-_ADP-_r12
controller: Jak

eco ECO:0000250 8
type: UnificationXref
id: ECO:0000250
db: eco

uniprot F1Q2Y3 354
type: UnificationXref
id: F1Q2Y3
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F6R1P6 501
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF79
xref: uniprot F6R8N9 70
organism: Macaca mulatta

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F6R8N3 217
organism: Macaca mulatta

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6VXG1 392
organism: Xenopus tropicalis

Mitogen-activated protein kinase 15
type: ProteinReference
xref: PTHR24055:SF79
xref: uniprot Q8TD08 103
organism: Homo sapiens

Interleukin 10 receptor subunit alpha
type: ProteinReference
xref: uniprot G3V830 425
xref: PTHR20859:SF43
organism: Rattus norvegicus

Signaling subunit
type: Protein
entity reference: Signaling subunit
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q5A1D3 94
type: UnificationXref
id: Q5A1D3
db: uniprot

Interleukin-9
type: ProteinReference
xref: uniprot P15248 170
organism: Homo sapiens

Interleukin-9
type: ProteinReference
xref: uniprot P15247 169
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF6
xref: uniprot F7GWU7 407
organism: Macaca mulatta

uniprot F1Q118 302
type: UnificationXref
id: F1Q118
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot Q6P943 531
xref: PTHR11801:SF18
organism: Danio rerio

uniprot A0A2I3TPM9 35
type: UnificationXref
id: A0A2I3TPM9
db: uniprot

ncbitaxon 237561 95
type: UnificationXref
id: 237561
db: ncbitaxon

Myc proto-oncogene protein
type: ProteinReference
xref: PTHR45851:SF1
xref: uniprot B8XIA5 480
organism: Macaca mulatta

Spi-C transcription factor
type: ProteinReference
xref: PTHR11849:SF17
xref: uniprot A0A2I3T2I1 376
organism: Pan troglodytes

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P01111 273
organism: Homo sapiens

uniprot B4F7D4 10
type: UnificationXref
id: B4F7D4
db: uniprot

Interleukin-20 receptor subunit alpha
type: ProteinReference
xref: PTHR20859:SF21
xref: uniprot Q9UHF4 469
organism: Homo sapiens

PTHR24349:SF114
type: RelationshipXref
id: PTHR24349:SF114
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: c-Myc

Forkhead box O3
type: ProteinReference
xref: uniprot D3ZBQ1 474
xref: PTHR45767:SF4
organism: Rattus norvegicus

Interleukin-5 receptor subunit alpha
type: ProteinReference
xref: PTHR23036:SF17
xref: uniprot Q01344 449
organism: Homo sapiens

SRF
type: Protein
entity reference: SRF
feature: SRF s99 a168 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot P01108 483
xref: PTHR45851:SF1
organism: Mus musculus

uniprot P20936 255
type: UnificationXref
id: P20936
db: uniprot

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot P01109 484
xref: PTHR45851:SF1
organism: Gallus gallus

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot P01106 482
xref: PTHR45851:SF1
organism: Homo sapiens

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot P01101 123
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Jak-RIGHT__Jak-_ADP-_r72
controller: Complex (Receptor subunit alpha/Receptor subunit beta/ Signaling subunit/Interleukin)

uniprot A0A2I3S8A4 34
type: UnificationXref
id: A0A2I3S8A4
db: uniprot

Proto-oncogene c-Fos
type: ProteinReference
xref: uniprot P01100 122
xref: PTHR23351:SF4
organism: Homo sapiens

uniprot P51812 55
type: UnificationXref
id: P51812
db: uniprot

uniprot Q9WUT3 61
type: UnificationXref
id: Q9WUT3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23036:SF101
xref: uniprot F6Z890 419
organism: Macaca mulatta

Interleukin 13 receptor subunit alpha 1
type: ProteinReference
xref: uniprot E2QZ78 417
xref: PTHR23036:SF89
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Grb2-_SOS-_Shc-RIGHT__Complex__Grb2_Shc__SOS_-_r19
controller: Src-like

HETERODIMER ASSOCIATION LEFT Receptor subunit alpha- Receptor subunit beta- Interleukin- Signaling subunit-RIGHT Complex Receptor subunit alpha Receptor subunit beta Signaling subunit Interleukin - r69
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 639
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 638
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 637
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 641
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 640
left: Receptor subunit beta
left: Signaling subunit
left: Interleukin
left: Receptor subunit alpha
display name: HETERODIMER_ASSOCIATION_LEFT__Receptor_subunit_alpha-_Receptor_subunit_beta-_Interleukin-_Signaling_subunit-RIGHT__Complex__Receptor_subunit_alpha_Receptor_subunit_beta__Signaling_subunit_Interleukin_-_r69
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Receptor subunit alpha/Receptor subunit beta/ Signaling subunit/Interleukin)

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot H2R8U9 307
xref: PTHR23113:SF168
organism: Pan troglodytes

Interleukin 12 receptor subunit beta 2
type: ProteinReference
xref: uniprot F1LRH7 230
xref: PTHR23036:SF79
organism: Rattus norvegicus

P00969
type: UnificationXref
id: P00969
db: PANTHER Pathway Component

P00967
type: UnificationXref
id: P00967
db: PANTHER Pathway Component

P00968
type: UnificationXref
id: P00968
db: PANTHER Pathway Component

P00965
type: UnificationXref
id: P00965
db: PANTHER Pathway Component

P00966
type: UnificationXref
id: P00966
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r47 588
type: Stoichiometry
physical entity: p27KIP1
stoichiometric coefficient: 1.0

P00964
type: UnificationXref
id: P00964
db: PANTHER Pathway Component

STAT
type: Protein
entity reference: STAT
feature: STAT s8 a14 rs2
feature: STAT s8 a14 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

P00962
type: UnificationXref
id: P00962
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r47 589
type: Stoichiometry
physical entity: p27KIP1
stoichiometric coefficient: 1.0

P00971
type: UnificationXref
id: P00971
db: PANTHER Pathway Component

uniprot P30367 176
type: UnificationXref
id: P30367
db: uniprot

uniprot O14920 132
type: UnificationXref
id: O14920
db: uniprot

P00970
type: UnificationXref
id: P00970
db: PANTHER Pathway Component

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot P27704 88
xref: PTHR24055:SF171
organism: Rattus norvegicus

uniprot F6TFL4 71
type: UnificationXref
id: F6TFL4
db: uniprot

uniprot H2R8U9 307
type: UnificationXref
id: H2R8U9
db: uniprot

ADP
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot F7C2C6 74
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UMX8 476
xref: PTHR45767:SF4
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_p21CIP1-RIGHT__ADP-_p21CIP1-_r44
controller: PKB

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot F6PGQ1 261
organism: Monodelphis domestica

uniprot P26952 446
type: UnificationXref
id: P26952
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_MAPKAPK2-RIGHT__ADP-_MAPKAPK2-_r53
controller: ERK

P00976
type: UnificationXref
id: P00976
db: PANTHER Pathway Component

P00977
type: UnificationXref
id: P00977
db: PANTHER Pathway Component

IRS1 2 s7 a13 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

P00978
type: UnificationXref
id: P00978
db: PANTHER Pathway Component

uniprot O88351 134
type: UnificationXref
id: O88351
db: uniprot

uniprot Q63257 460
type: UnificationXref
id: Q63257
db: uniprot

P00979
type: UnificationXref
id: P00979
db: PANTHER Pathway Component

P00972
type: UnificationXref
id: P00972
db: PANTHER Pathway Component

P00973
type: UnificationXref
id: P00973
db: PANTHER Pathway Component

P00974
type: UnificationXref
id: P00974
db: PANTHER Pathway Component

P00975
type: UnificationXref
id: P00975
db: PANTHER Pathway Component

P00980
type: UnificationXref
id: P00980
db: PANTHER Pathway Component

Receptor subunit alpha
type: ProteinReference
xref: P00992
standard name: Interleukin receptor beta subunit
comment: ENTITY_REFERENCE_NOTES=Long Name: Receptor subunit alpha Synonym: Synonym not specified Accession: P00992
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.RECEPTOR.Receptor_br_subunit_space__alpha_
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Interleukin-6 receptor subunit alpha
member entity reference: Interleukin 5 receptor subunit alpha
member entity reference: Interleukin-10 receptor subunit alpha
member entity reference: Interleukin-23 subunit alpha
member entity reference: Uncharacterized protein
member entity reference: IL10RA isoform 2
member entity reference: C-X-C chemokine receptor type 1
member entity reference: Interleukin-20 receptor subunit alpha
member entity reference: Interleukin 10 receptor subunit alpha
member entity reference: Interleukin-13 receptor subunit alpha-2
member entity reference: Interleukin-5 receptor subunit alpha
member entity reference: Interleukin-13 receptor subunit alpha-1
member entity reference: Interleukin 13 receptor, alpha 1
member entity reference: Interleukin 13 receptor subunit alpha 1
member entity reference: Interleukin-2 receptor subunit alpha
member entity reference: Interleukin-3 receptor subunit alpha
member entity reference: Interleukin 15 receptor subunit alpha
member entity reference: Interleukin-15 receptor subunit alpha
member entity reference: Interleukin 13 receptor subunit alpha 2
member entity reference: Interleukin-4 receptor subunit alpha
member entity reference: IL20RA isoform 2
member entity reference: Interleukin-2 receptor subunit alpha (Fragment)
member entity reference: Interleukin 4 receptor
member entity reference: Interleukin 6 receptor
member entity reference: IL13RA1 isoform 1
member entity reference: Interleukin-11 receptor subunit alpha
member entity reference: IL2RA protein
member entity reference: IL23A isoform 3
member entity reference: Interleukin-11 receptor subunit alpha-1
member entity reference: Interleukin-1 alpha
member entity reference: Galactose-1-phosphate uridylyltransferase
member entity reference: Interleukin-11 receptor subunit alpha-2

P00982
type: UnificationXref
id: P00982
db: PANTHER Pathway Component

P00981
type: UnificationXref
id: P00981
db: PANTHER Pathway Component

SHC-transforming protein 1
type: ProteinReference
xref: uniprot Q0IIE2 541
xref: PTHR10337:SF2
organism: Bos taurus

uniprot F7CW94 507
type: UnificationXref
id: F7CW94
db: uniprot

STATE_TRANSITION_LEFT__ATP-_Jak-RIGHT__Jak-_ADP-_r72
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 625
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 626
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 624
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 623
left: Jak
left: ATP
interaction type: STATE_TRANSITION
right: Jak
right: ADP

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot Q68SP3 529
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r41 619
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot D3Z8E0 40
type: UnificationXref
id: D3Z8E0
db: uniprot

Src-like
type: Protein
entity reference: Src-like
feature: Src like s47 a67 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ERK s24 a34 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Interleukin-4
type: ProteinReference
xref: uniprot A0A140TAX8 146
organism: Pan troglodytes

uniprot P28028 343
type: UnificationXref
id: P28028
db: uniprot

Interleukin-2 receptor subunit beta
type: ProteinReference
xref: uniprot F7GSZ4 233
xref: PTHR23037:SF30
organism: Macaca mulatta

uniprot P97604 187
type: UnificationXref
id: P97604
db: uniprot

RAS p21 protein activator 1
type: ProteinReference
xref: uniprot F7EPN2 253
xref: PTHR10194:SF19
organism: Ornithorhynchus anatinus

TRANSPORT_LEFT__ERK-RIGHT__ERK-_r49
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 579
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 580
left: ERK
interaction type: TRANSPORT
right: ERK

IRS1/2
type: Protein
entity reference: IRS1/2
feature: IRS1 2 s7 a13 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Shc
type: Protein
entity reference: Shc
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot F1MX38 498
organism: Bos taurus

Receptor subunit alpha
type: Protein
entity reference: Receptor subunit alpha
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r41 622
type: Stoichiometry
physical entity: eNOS
stoichiometric coefficient: 1.0

uniprot E2RB53 260
type: UnificationXref
id: E2RB53
db: uniprot

PARTICIPANT STOICHIOMETRY r41 621
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r41 620
type: Stoichiometry
physical entity: eNOS
stoichiometric coefficient: 1.0

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot P19419 19
organism: Homo sapiens

Interleukin 6
type: ProteinReference
xref: uniprot A0A2I3SUM2 148
organism: Pan troglodytes

uniprot Q28519 245
type: UnificationXref
id: Q28519
db: uniprot

Interleukin-2 receptor subunit beta
type: ProteinReference
xref: PTHR23037:SF30
xref: uniprot P16297 238
organism: Mus musculus

Mitogen-activated protein kinase 6
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot Q61532 97
organism: Mus musculus

IL11 isoform 1
type: ProteinReference
xref: PTHR16922:SF0
xref: uniprot H2QH62 154
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5NUC4 348
organism: Gallus gallus

Interleukin-6 receptor subunit beta
type: ProteinReference
xref: PTHR23036:SF83
xref: uniprot P40190 142
organism: Rattus norvegicus

Interleukin-13 receptor subunit alpha-2
type: ProteinReference
xref: PTHR23036:SF101
xref: uniprot Q95LF0 465
organism: Canis lupus familiaris

uniprot Q60819 458
type: UnificationXref
id: Q60819
db: uniprot

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 269

uniprot Q64315 473
type: UnificationXref
id: Q64315
db: uniprot

uniprot F1PW15 481
type: UnificationXref
id: F1PW15
db: uniprot

STATE_TRANSITION_LEFT__ATP-_STAT-RIGHT__STAT-_ADP-_r12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 601
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 602
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 600
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 599
left: STAT
left: ATP
interaction type: STATE_TRANSITION
right: STAT
right: ADP

MAP kinase-interacting serine/threonine-protein kinase 2 isoform 2
type: ProteinReference
xref: uniprot H9EP11 196
xref: PTHR24349:SF254
organism: Macaca mulatta

uniprot P35570 296
type: UnificationXref
id: P35570
db: uniprot

uniprot A0A2I3T9Y4 207
type: UnificationXref
id: A0A2I3T9Y4
db: uniprot

uniprot D4A9V6 11
type: UnificationXref
id: D4A9V6
db: uniprot

uniprot H2R8L2 538
type: UnificationXref
id: H2R8L2
db: uniprot

uniprot F6QE96 215
type: UnificationXref
id: F6QE96
db: uniprot

uniprot E2QVW3 12
type: UnificationXref
id: E2QVW3
db: uniprot

PKB
type: ProteinReference
xref: P00973
standard name: Protein kinase B
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.PKB
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein kinase B Synonym: Akt,PKB Accession: P00973
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC-gamma serine/threonine-protein kinase
member entity reference: RAC-beta serine/threonine-protein kinase
member entity reference: RAC-alpha serine/threonine-protein kinase

Interleukin-3 receptor subunit alpha
type: ProteinReference
xref: PTHR23036:SF175
xref: uniprot P26951 445
organism: Homo sapiens

STAT
type: Protein
entity reference: STAT
feature: STAT s113 a173 rs2
feature: STAT s113 a173 rs1
feature: ACTIVE 31

Interleukin-3 receptor subunit alpha
type: ProteinReference
xref: uniprot P26952 446
xref: PTHR23036:SF170
organism: Mus musculus

uniprot F6XP81 219
type: UnificationXref
id: F6XP81
db: uniprot

Cytokine receptor common subunit beta
type: ProteinReference
xref: uniprot P26955 241
xref: PTHR23037:SF22
organism: Mus musculus

Interleukin-3 receptor class 2 subunit beta
type: ProteinReference
xref: PTHR23037:SF22
xref: uniprot P26954 240
organism: Mus musculus

uniprot P04049 333
type: UnificationXref
id: P04049
db: uniprot

STATE_TRANSITION_LEFT__ATP-_MEK-RIGHT__MEK-_ADP-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 564
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 562
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 561
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 563
left: MEK
left: ATP
interaction type: STATE_TRANSITION
right: MEK
right: ADP

uniprot P35568 294
type: UnificationXref
id: P35568
db: uniprot

uniprot F7DNM3 252
type: UnificationXref
id: F7DNM3
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot A0A1D5QUZ8 63
organism: Macaca mulatta

uniprot F1NCY7 282
type: UnificationXref
id: F1NCY7
db: uniprot

uniprot H9FU32 332
type: UnificationXref
id: H9FU32
db: uniprot

PTHR24055:SF158
type: RelationshipXref
id: PTHR24055:SF158
db: PANTHER Family
relationship type: By Homology

Interleukin-8
type: ProteinReference
xref: PTHR10179:SF42
xref: uniprot P10145 168
organism: Homo sapiens

GDP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2Q9G3 81
type: UnificationXref
id: H2Q9G3
db: uniprot

uniprot D3ZBQ1 474
type: UnificationXref
id: D3ZBQ1
db: uniprot

Interleukin-6
type: ProteinReference
xref: uniprot P05231 164
organism: Homo sapiens

ncbitaxon 7227 60
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot P05112 163
type: UnificationXref
id: P05112
db: uniprot

uniprot Q9Y4H2 297
type: UnificationXref
id: Q9Y4H2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKB-RIGHT__Pi-_PKB-_r48
controller: CTMP

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
evidence: Evidence 204
evidence: Evidence 205
xref: PTHR24349:SF114
xref: uniprot Q9BUB5 203
organism: Homo sapiens

uniprot P39689 472
type: UnificationXref
id: P39689
db: uniprot

TRANSPORT_LEFT__p21CIP1-RIGHT__p21CIP1-_r46
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 594
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 593
left: p21CIP1
interaction type: TRANSPORT
right: p21CIP1

Tyrosine-protein kinase JAK3
type: ProteinReference
xref: PTHR45807:SF3
xref: uniprot Q62137 280
organism: Mus musculus

STATE_TRANSITION_LEFT__ATP-_STAT-RIGHT__STAT-_ADP-_r68
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 644
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 643
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 642
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 645
left: ATP
left: STAT
interaction type: STATE_TRANSITION
right: ADP
right: STAT

uniprot A0A1D5QGM1 359
type: UnificationXref
id: A0A1D5QGM1
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot H2QLB4 82
organism: Pan troglodytes

PDK1/2
type: Protein
entity reference: PDK1/2
feature: ACTIVE 31
feature: PDK1 2 s33 a48 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: uniprot Q04982 344
xref: PTHR44329:SF47
organism: Gallus gallus

uniprot O08769 317
type: UnificationXref
id: O08769
db: uniprot

SPIB
type: ProteinReference
xref: uniprot C0KXH8 377
xref: PTHR11849:SF174
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r35 653
type: Stoichiometry
physical entity: PKB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r35 652
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r35 655
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r35 654
type: Stoichiometry
physical entity: PKB
stoichiometric coefficient: 1.0

PTHR24055:SF171
type: RelationshipXref
id: PTHR24055:SF171
db: PANTHER Family
relationship type: By Homology

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF47
xref: uniprot E2RE22 496
organism: Canis lupus familiaris

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5Q5Z6 62
xref: PTHR24055:SF393
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r9 558
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 559
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 557
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

Interleukin 6 receptor
type: ProteinReference
xref: uniprot H2Q053 427
organism: Pan troglodytes

IRS1/2
type: ProteinReference
xref: P00980
standard name: Insulin receptor substrate family
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Insulin receptor substrate family Synonym: IRS2,IRS3,IRS4,family includes IRS1 Accession: P00980
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.IRS1/2
member entity reference: Insulin receptor substrate 1
member entity reference: Uncharacterized protein
member entity reference: IRS1 isoform 1
member entity reference: Insulin receptor substrate 2

p90RSK s80 a147 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A0A452DI16 328
type: UnificationXref
id: A0A452DI16
db: uniprot

STATE_TRANSITION_LEFT__Ras-_GTP-RIGHT__GDP-_Ras-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 577
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 575
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 576
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 578
left: GTP
left: Ras
interaction type: STATE_TRANSITION
right: Ras
right: GDP

STATE_TRANSITION
type: InteractionVocabulary

uniprot P29353 539
type: UnificationXref
id: P29353
db: uniprot

TRANSPORT
type: InteractionVocabulary

uniprot Q9HBH9 206
type: UnificationXref
id: Q9HBH9
db: uniprot

Interleukin-15
type: ProteinReference
xref: uniprot P97604 187
organism: Rattus norvegicus

uniprot H2Q053 427
type: UnificationXref
id: H2Q053
db: uniprot

uniprot F7G4D2 371
type: UnificationXref
id: F7G4D2
db: uniprot

PARTICIPANT STOICHIOMETRY r9 560
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

PDK1 2 s32 a47 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

RAS p21 protein activator 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot E9PYG6 250
organism: Mus musculus

Pi
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=ION

Extracellular signal-regulated kinase 1
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot Q5A1D3 94
organism: Candida albicans

uniprot P41971 28
type: UnificationXref
id: P41971
db: uniprot

uniprot F6PX17 284
type: UnificationXref
id: F6PX17
db: uniprot

Insulin receptor substrate 1
type: ProteinReference
xref: PTHR10614:SF11
xref: uniprot P35569 295
organism: Mus musculus

Insulin receptor substrate 1
type: ProteinReference
xref: PTHR10614:SF11
xref: uniprot P35568 294
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Src_like-RIGHT__ADP-_Src_like-_r18
controller: Src-like

uniprot A0A3Q1NH21 208
type: UnificationXref
id: A0A3Q1NH21
db: uniprot

STATE_TRANSITION_LEFT__PIP2-RIGHT__PIP3-_r33
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 662
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 663
left: PIP2
interaction type: STATE_TRANSITION
right: PIP3

uniprot P52630 523
type: UnificationXref
id: P52630
db: uniprot

uniprot Q9WVH4 479
type: UnificationXref
id: Q9WVH4
db: uniprot

uniprot G3V830 425
type: UnificationXref
id: G3V830
db: uniprot

Interleukin-12 receptor subunit beta-2
type: ProteinReference
xref: uniprot F1MEB5 231
xref: PTHR23036:SF79
organism: Bos taurus

STATE_TRANSITION_LEFT__ATP-_Src_like-RIGHT__ADP-_Src_like-_r18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 571
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 573
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 572
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 574
left: Src-like
left: ATP
interaction type: STATE_TRANSITION
right: Src-like
right: ADP

Interleukin-8
type: ProteinReference
xref: uniprot P41324 178
xref: PTHR10179:SF42
organism: Canis lupus familiaris

SOS
type: ProteinReference
xref: P00981
standard name: Son of sevenless
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Son of Sevenless Synonym: SOS Accession: P00981
comment: ENTITY_REFERENCE_ID_DESC=Interleukin signaling pathway.PROTEIN.GENERIC.SOS
member entity reference: Son of sevenless homolog 2
member entity reference: SOS Ras/Rho guanine nucleotide exchange factor 2
member entity reference: SOS Ras/Rac guanine nucleotide exchange factor 1
member entity reference: Uncharacterized protein
member entity reference: Son of sevenless homolog 1

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF48
xref: uniprot F6UMM2 503
organism: Macaca mulatta

uniprot P22273 442
type: UnificationXref
id: P22273
db: uniprot

Insulin receptor substrate 1
type: ProteinReference
xref: PTHR10614:SF11
xref: uniprot P35570 296
organism: Rattus norvegicus

uniprot Q14626 452
type: UnificationXref
id: Q14626
db: uniprot

p21CIP1 s59 a104 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

STATE_TRANSITION_LEFT__ATP-_PKB-RIGHT__PKB-_ADP-_r35
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 655
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 652
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 654
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 653
left: PKB
left: ATP
interaction type: STATE_TRANSITION
right: PKB
right: ADP

ELK s30 a43 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A0A1D5R9U8 320
type: UnificationXref
id: A0A1D5R9U8
db: uniprot

uniprot Q9WVL2 533
type: UnificationXref
id: Q9WVL2
db: uniprot

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: PTHR24349:SF114
xref: uniprot Q58D94 199
organism: Bos taurus

uniprot F7EEK4 470
type: UnificationXref
id: F7EEK4
db: uniprot

Ras
type: Protein
entity reference: Ras
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P42345 114
type: UnificationXref
id: P42345
db: uniprot

uniprot P01111 273
type: UnificationXref
id: P01111
db: uniprot