uniprot F6UQZ6 382
type: UnificationXref
id: F6UQZ6
db: uniprot

PTHR11958:SF24
type: RelationshipXref
id: PTHR11958:SF24
db: PANTHER Family
relationship type: By Homology

uniprot Q8R1Q0 258
type: UnificationXref
id: Q8R1Q0
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_r71
control type: ACTIVATION
controller: s218

Neuronal synaptobrevin, isoform J
type: ProteinReference
xref: PTHR45701:SF3
xref: uniprot M9PE71 218
organism: Drosophila melanogaster

uniprot H2QD95 339
type: UnificationXref
id: H2QD95
db: uniprot

PTHR11958:SF22
type: RelationshipXref
id: PTHR11958:SF22
db: PANTHER Family
relationship type: By Homology

uniprot F1NKF1 309
type: UnificationXref
id: F1NKF1
db: uniprot

uniprot A0A2I3TH19 377
type: UnificationXref
id: A0A2I3TH19
db: uniprot

Amino acid transporter
type: ProteinReference
xref: uniprot A0A1D5Q6W9 141
xref: PTHR11958:SF24
organism: Macaca mulatta

uniprot Q62083 193
type: UnificationXref
id: Q62083
db: uniprot

Protein shank
type: ProteinReference
xref: uniprot B7WN72 33
xref: PTHR24135:SF18
organism: Caenorhabditis elegans

Vesicular glutamate transporter 2
type: ProteinReference
xref: uniprot Q9P2U8 373
xref: PTHR11662:SF201
organism: Homo sapiens

uniprot Q6P4V2 182
type: UnificationXref
id: Q6P4V2
db: uniprot

Amino acid transporter
type: ProteinReference
xref: uniprot A8WZ27 146
xref: PTHR11958:SF98
organism: Caenorhabditis briggsae

Syntaxin 19
type: ProteinReference
xref: PTHR19957:SF29
xref: uniprot H2QMZ0 215
organism: Pan troglodytes

uniprot F1MG21 73
type: UnificationXref
id: F1MG21
db: uniprot

Amino acid transporter
type: ProteinReference
xref: uniprot F6ZDV3 158
xref: PTHR11958:SF93
organism: Macaca mulatta

uniprot P34299 328
type: UnificationXref
id: P34299
db: uniprot

uniprot Q9BV40 261
type: UnificationXref
id: Q9BV40
db: uniprot

STX11 isoform 1
type: ProteinReference
xref: PTHR19957:SF30
xref: uniprot H2QTV4 216
organism: Pan troglodytes

Metabotropic glutamate receptor 3
type: ProteinReference
xref: uniprot Q14832 284
xref: PTHR24060:SF160
organism: Homo sapiens

STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_r58
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 544
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 545
left: Ca2+ channel
interaction type: STATE_TRANSITION
right: Ca2+ channel

Mus musculus
type: BioSource
xref: ncbitaxon 10090 19

Uncharacterized protein
type: ProteinReference
xref: uniprot F6V5G0 276
xref: PTHR24060:SF160
organism: Monodelphis domestica

uniprot Q6PHZ2 398
type: UnificationXref
id: Q6PHZ2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XYX9 207
xref: PTHR45701:SF6
organism: Monodelphis domestica

Ionotropic glutamate receptor AMPA 1
type: ProteinReference
xref: PTHR18966:SF157
xref: uniprot G0T3G6 325
organism: Bos taurus

Putative sodium-dependent excitatory amino acid transporter glt-4
type: ProteinReference
xref: uniprot Q22682 180
xref: PTHR11958:SF98
organism: Caenorhabditis elegans

Amino acid transporter
type: ProteinReference
xref: uniprot F7FKB2 160
xref: PTHR11958:SF24
organism: Monodelphis domestica

uniprot H2R3D0 366
type: UnificationXref
id: H2R3D0
db: uniprot

uniprot A0A286Y9Q6 295
type: UnificationXref
id: A0A286Y9Q6
db: uniprot

uniprot P60877 231
type: UnificationXref
id: P60877
db: uniprot

uniprot F6YX10 365
type: UnificationXref
id: F6YX10
db: uniprot

PTHR19305:SF14
type: RelationshipXref
id: PTHR19305:SF14
db: PANTHER Family
relationship type: By Homology

Voltage-dependent calcium channel gamma-2 subunit
type: ProteinReference
xref: uniprot O88602 18
organism: Mus musculus

Protein interacting with PRKCA 1
type: ProteinReference
xref: uniprot E2RPE0 190
xref: PTHR12141:SF1
organism: Canis lupus familiaris

PICK
type: Protein
entity reference: PICK
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 423
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

N-methyl D-aspartate receptor subtype 2B
type: ProteinReference
evidence: Evidence 106
evidence: Evidence 91
xref: uniprot F6T8S6 109
xref: PTHR18966:SF382
organism: Macaca mulatta

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Glutamate-RIGHT__Glutamate-_r66
control type: ACTIVATION
controller: Complex (SNARE Complex/Ca2+)

DISSOCIATION_LEFT__Complex__EAAT_Glutamate_-RIGHT__Glutamate-_EAAT-_r116
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r116 521
participant stoichiometry: PARTICIPANT STOICHIOMETRY r116 522
participant stoichiometry: PARTICIPANT STOICHIOMETRY r116 523
left: Complex (EAAT/Glutamate)
interaction type: DISSOCIATION
right: EAAT
right: Glutamate

Amino acid transporter
type: ProteinReference
xref: uniprot O77062 167
xref: PTHR11958:SF63
organism: Drosophila melanogaster

uniprot A2CG69 297
type: UnificationXref
id: A2CG69
db: uniprot

uniprot P23819 316
type: UnificationXref
id: P23819
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot F6UFJ7 206
organism: Macaca mulatta

Glu1
type: Protein
entity reference: Glu1
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

Glutamate ionotropic receptor NMDA type subunit 2A
type: ProteinReference
evidence: Evidence 115
evidence: Evidence 106
evidence: Evidence 92
evidence: Evidence 91
xref: PTHR18966:SF407
xref: uniprot F1PXS6 97
organism: Canis lupus familiaris

NR2B
type: ProteinReference
xref: P01007
standard name: Glutamate/NMDA receptor epsilon 2 subunit / e 2 subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Glutamate/NMDA receptor epsilon 2 subunit / e 2 subunit Synonym: Glutamate/NMDA receptor epsilon 2 subunit / e 2 subunit Accession: P01007
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.NR2B
member entity reference: Uncharacterized protein
member entity reference: Glutamate receptor ionotropic, NMDA 2A
member entity reference: Glutamate receptor ionotropic, NMDA 2B
member entity reference: N-methyl D-aspartate receptor subtype 2B
member entity reference: Glutamate ionotropic receptor NMDA type subunit 2A
member entity reference: GRIN2B isoform 3

Vesicle-fusing ATPase
type: ProteinReference
xref: uniprot Q75JI3 350
xref: PTHR23078:SF3
organism: Dictyostelium discoideum

PARTICIPANT STOICHIOMETRY r38 474
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 347

Glutamate receptor ionotropic, kainate 1
type: ProteinReference
xref: uniprot P22756 87
xref: PTHR18966:SF36
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r38 475
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot G5EEN8 212
type: UnificationXref
id: G5EEN8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot F7F746 301
organism: Macaca mulatta

NR3
type: Protein
entity reference: NR3
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3S1J9 44
type: UnificationXref
id: A0A2I3S1J9
db: uniprot

uniprot P35439 132
type: UnificationXref
id: P35439
db: uniprot

ncbitaxon 9615 46
type: UnificationXref
id: 9615
db: ncbitaxon

PTHR11958:SF63
type: RelationshipXref
id: PTHR11958:SF63
db: PANTHER Family
relationship type: By Homology

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60879 233
xref: PTHR19305:SF5
organism: Mus musculus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60878 232
xref: PTHR19305:SF5
organism: Gallus gallus

uniprot A0A2I3SR99 198
type: UnificationXref
id: A0A2I3SR99
db: uniprot

Vglut
type: Protein
entity reference: Vglut
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot E2QUL1 119
type: UnificationXref
id: E2QUL1
db: uniprot

ncbitaxon 9544 8
type: UnificationXref
id: 9544
db: ncbitaxon

Putative synaptobrevin homologue SNC1/2 (Eurofung)
type: ProteinReference
xref: uniprot Q5ASG1 248
organism: Emericella nidulans

Amino acid transporter (Fragment)
type: ProteinReference
xref: PTHR11958:SF63
xref: uniprot Q5TXC3 181
organism: Anopheles gambiae

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60877 231
xref: PTHR19305:SF5
organism: Macaca mulatta

TRANSPORT_LEFT__Complex__Glu4_Glu3__Glu2_-RIGHT__AMPA-_r130
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r130 509
participant stoichiometry: PARTICIPANT STOICHIOMETRY r130 510
left: Complex (Glu4/Glu3/ Glu2)
interaction type: TRANSPORT
right: AMPA

PTHR11958:SF67
type: RelationshipXref
id: PTHR11958:SF67
db: PANTHER Family
relationship type: By Homology

uniprot F1MBY1 308
type: UnificationXref
id: F1MBY1
db: uniprot

uniprot Q10914 318
type: UnificationXref
id: Q10914
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 10

uniprot Q8BMF5 61
type: UnificationXref
id: Q8BMF5
db: uniprot

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60880 234
xref: PTHR19305:SF5
organism: Homo sapiens

uniprot Q63666 253
type: UnificationXref
id: Q63666
db: uniprot

a150_degraded
type: PhysicalEntity
cellular location: lysosome
comment: SPECIES_TYPE=DEGRADED

uniprot F7B4C1 324
type: UnificationXref
id: F7B4C1
db: uniprot

uniprot E2RHU1 298
type: UnificationXref
id: E2RHU1
db: uniprot

uniprot F1NU20 74
type: UnificationXref
id: F1NU20
db: uniprot

uniprot P11798 389
type: UnificationXref
id: P11798
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q2KJD2 246
organism: Bos taurus

AGAP000803-PA
type: ProteinReference
xref: uniprot Q7QE65 407
organism: Anopheles gambiae

Excitatory amino acid transporter 4
type: ProteinReference
xref: PTHR11958:SF67
xref: uniprot O35921 166
organism: Rattus norvegicus

Glutamate receptor, ionotropic, AMPA 4a
type: ProteinReference
xref: uniprot F1QA08 289
xref: PTHR18966:SF488
organism: Danio rerio

Glutamate ionotropic receptor AMPA type subunit 4
type: ProteinReference
xref: PTHR18966:SF100
xref: uniprot A0A2I3T3T7 287
organism: Pan troglodytes

uniprot P43004 171
type: UnificationXref
id: P43004
db: uniprot

Glutamate receptor ionotropic, NMDA 3B
type: ProteinReference
evidence: Evidence 91
evidence: Evidence 117
xref: uniprot Q8VHN2 123
xref: PTHR18966:SF364
organism: Rattus norvegicus

uniprot A5PEW5 199
type: UnificationXref
id: A5PEW5
db: uniprot

uniprot P19493 292
type: UnificationXref
id: P19493
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63044 239
organism: Mus musculus

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63045 240
organism: Rattus norvegicus

Glutamate receptor 1
type: ProteinReference
xref: PTHR18966:SF157
xref: uniprot P23818 327
organism: Mus musculus

uniprot Q6R6I2 136
type: UnificationXref
id: Q6R6I2
db: uniprot

uniprot P43006 173
type: UnificationXref
id: P43006
db: uniprot

AMPA
type: Protein
entity reference: AMPA
cellular location: lysosome
comment: SPECIES_TYPE=PROTEIN

Synaptobrevin-1
type: ProteinReference
xref: PTHR45701:SF3
xref: uniprot O02495 220
organism: Caenorhabditis elegans

HETERODIMER_ASSOCIATION_LEFT__Glu2-_Glu3-_Glu4-RIGHT__Complex__Glu4_Glu3__Glu2_-_r134
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r134 489
participant stoichiometry: PARTICIPANT STOICHIOMETRY r134 492
participant stoichiometry: PARTICIPANT STOICHIOMETRY r134 491
participant stoichiometry: PARTICIPANT STOICHIOMETRY r134 490
left: Glu3
left: Glu4
left: Glu2
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Glu4/Glu3/ Glu2)

HETERODIMER_ASSOCIATION_LEFT__EAAT-_Glutamate-RIGHT__Complex__EAAT_Glutamate_-_r115
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r115 524
participant stoichiometry: PARTICIPANT STOICHIOMETRY r115 525
participant stoichiometry: PARTICIPANT STOICHIOMETRY r115 526
left: Glutamate
left: EAAT
interaction type: HETERODIMER_ASSOCIATION
right: Complex (EAAT/Glutamate)

axon terminus
type: CellularLocationVocabulary
xref: GO GO:0043679 6

Glutamate receptor 2
type: ProteinReference
evidence: Evidence 306
xref: PTHR18966:SF99
xref: uniprot P23819 316
organism: Mus musculus

uniprot P46411 174
type: UnificationXref
id: P46411
db: uniprot

KA1
type: ProteinReference
xref: P01004
standard name: Glutamate receptor, ionotropic kainate 1
comment: ENTITY_REFERENCE_NOTES=Long Name: glutamate receptor, ionotropic, kainate 1 Synonym: EAA3,EEA3,GLR5,GLUR5,GRIK1 Accession: P01004
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.KA1
member entity reference: Glutamate receptor ionotropic, kainate 1
member entity reference: GRIK1 isoform 7
member entity reference: Glutamate receptor, ionotropic, kainate 1
member entity reference: Glutamate ionotropic receptor kainate type subunit 1
member entity reference: GRIK1 protein
member entity reference: Uncharacterized protein

Syntaxin-11
type: ProteinReference
xref: uniprot F6R0Q4 204
xref: PTHR19957:SF30
organism: Macaca mulatta

uniprot Q9Z2W8 294
type: UnificationXref
id: Q9Z2W8
db: uniprot

Vesicle-associated membrane protein 8 (Endobrevin)
type: ProteinReference
xref: uniprot Q7ZUC1 256
xref: PTHR45701:SF7
organism: Danio rerio

uniprot A1Z9K8 29
type: UnificationXref
id: A1Z9K8
db: uniprot

PTHR11958:SF89
type: RelationshipXref
id: PTHR11958:SF89
db: PANTHER Family
relationship type: By Homology

uniprot F6TYP9 299
type: UnificationXref
id: F6TYP9
db: uniprot

PSD95 s219 a182 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PSD95
stoichiometric coefficient: 1.0

GO GO:0005764 3
type: UnificationXref
id: GO:0005764
db: GO

Excitatory amino acid transporter 3
type: ProteinReference
xref: PTHR11958:SF97
xref: uniprot P51907 177
organism: Rattus norvegicus

Excitatory amino acid transporter 3
type: ProteinReference
xref: PTHR11958:SF97
xref: uniprot P51906 176
organism: Mus musculus

Glutamate
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

GLutamate Receptor family (AMPA)
type: ProteinReference
xref: PTHR18966:SF295
xref: uniprot Q8MXV8 408
organism: Caenorhabditis elegans

uniprot F1NGS8 380
type: UnificationXref
id: F1NGS8
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63027 238
xref: PTHR45701:SF5
organism: Homo sapiens

PANTHER Pathway P00037 1
type: UnificationXref
id: P00037
db: PANTHER Pathway

uniprot C7G3L6 64
type: UnificationXref
id: C7G3L6
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63026 237
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
evidence: Evidence 306
xref: PTHR18966:SF99
xref: uniprot F1MBY1 308
organism: Bos taurus

Ionotropic glutamate receptor pathway
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__Glu2-_Glu1-_Glu4-RIGHT__Complex__Glu4_Glu2__Glu1_-_r133
pathway component: STATE_TRANSITION_LEFT__AMPA-RIGHT__a151_degraded-_r104
pathway component: TRANSPORT_LEFT__AMPA-RIGHT__A_K-_r129
pathway component: HETERODIMER_ASSOCIATION_LEFT__Glu2-_Glu3-_Glu4-RIGHT__Complex__Glu4_Glu3__Glu2_-_r134
pathway component: TRANSPORT_LEFT__Na_PLUS_-RIGHT__Na_PLUS_-_r119
pathway component: TRANSPORT_LEFT__Complex__Glu4_Glu2__Glu1_-RIGHT__AMPA-_r131
pathway component: TRANSPORT_LEFT__Complex__Glu4_Glu3__Glu2_-RIGHT__AMPA-_r130
pathway component: HETERODIMER_ASSOCIATION_LEFT__KA4-_KA5-_KA3-_KA1-_KA2-RIGHT__KA-_r123
pathway component: STATE_TRANSITION_LEFT__NMDA-RIGHT__a150_degraded-_r102
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r69
pathway component: TRANSPORT_LEFT__NMDA-RIGHT__NMDA-_r97
pathway component: HETERODIMER_ASSOCIATION_LEFT__NR2D-_NR2A-RIGHT__NMDA-_r93
pathway component: HETERODIMER_ASSOCIATION_LEFT__Glutamate-_A_K-RIGHT__s221-_re40
pathway component: TRANSPORT_LEFT__NMDA-_PSD95-RIGHT__Complex__NMDA_PSD95_-_r122
pathway component: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_r71
pathway component: DISSOCIATION_LEFT__Complex__Vglut_Glutamate_-RIGHT__Vglut-_Glutamate-_r113
pathway component: STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_r58
pathway component: TRANSPORT_LEFT__KA-RIGHT__KA-_r95
pathway component: HETERODIMER_ASSOCIATION_LEFT__NR3-_NR2C-RIGHT__NMDA-_r106
pathway component: TRANSPORT_LEFT__Complex__Glu4_Glu2__Glu1_-RIGHT__AMPA-_r127
pathway component: HETERODIMER_ASSOCIATION_LEFT__SNARE_Complex-_Ca2_PLUS_-RIGHT__Complex__SNARE_Complex_Ca2_PLUS__-_r111
pathway component: HETERODIMER_ASSOCIATION_LEFT__NR1-_NR2B-RIGHT__NMDA-_r94
pathway component: HETERODIMER_ASSOCIATION_LEFT__KA-_Glutamate-RIGHT__Complex__KA_Glutamate_-_r117
pathway component: TRANSPORT_LEFT__Complex__Glu4_Glu3__Glu2_-RIGHT__A_K-_r128
pathway component: TRANSPORT_LEFT__Glutamate-RIGHT__Glutamate-_r66
pathway component: HETERODIMER_ASSOCIATION_LEFT__mGluR_2_3-_Glutamate-RIGHT__Complex__mGluR_2_3__Glutamate_-_r109
pathway component: DISSOCIATION_LEFT__Complex__EAAT_Glutamate_-RIGHT__Glutamate-_EAAT-_r116
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re41
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__NMDA_PSD95_-_Glutamate-RIGHT__s218-_re39
pathway component: HETERODIMER_ASSOCIATION_LEFT__EAAT-_Glutamate-RIGHT__Complex__EAAT_Glutamate_-_r115
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r38
pathway component: TRANSPORT_LEFT__KA-RIGHT__A_K-_r75
pathway component: HETERODIMER_ASSOCIATION_LEFT__Vglut-_Glutamate-RIGHT__Complex__Vglut_Glutamate_-_r112
pathway component: STATE_TRANSITION_LEFT__KA-RIGHT__a152_degraded-_r105
xref: PANTHER Pathway P00037 1
comment: MODEL_NOTES=Panther Pathway: P00037 Ionotropic Glutamate Receptors (iGluRs) are responsible for fast, reliable neutortansmission in the vertebrate central nervous system, i.e. they mediate signals associated with all 5 senses in brain and spinal cord, and are essential for learning and memory. Activity of iGluRs and levels of glutamate are tightly controlled by metabotropic glutamate receptors, and secondarily by other receptor types. Website=http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html Website=http://www.georgetown.edu/departments/pharmacology/sheng.pdf

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF38
xref: uniprot F7G485 76
organism: Monodelphis domestica

Glutamate s11 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Amino acid transporter
type: ProteinReference
xref: uniprot F6PQH1 154
xref: PTHR11958:SF93
organism: Ornithorhynchus anatinus

Glutamate receptor ionotropic, kainate 4
type: ProteinReference
xref: uniprot Q16099 59
xref: PTHR18966:SF171
organism: Homo sapiens

Amino acid transporter
type: ProteinReference
xref: uniprot A0A2I3TTD0 144
xref: PTHR11958:SF22
organism: Pan troglodytes

Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta
type: ProteinReference
xref: PTHR24347:SF365
xref: uniprot F6UQZ6 382
organism: Xenopus tropicalis

Glu1
type: Protein
entity reference: Glu1
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa17 449
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63024 235
organism: Mus musculus

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63025 236
organism: Rattus norvegicus

Glutamate receptor ionotropic, NMDA3A
type: ProteinReference
evidence: Evidence 91
evidence: Evidence 117
xref: PTHR18966:SF397
xref: uniprot A2AIR5 116
organism: Mus musculus

ncbitaxon 36329 341
type: UnificationXref
id: 36329
db: ncbitaxon

uniprot H2QLA1 214
type: UnificationXref
id: H2QLA1
db: uniprot

uniprot H2Q5I0 110
type: UnificationXref
id: H2Q5I0
db: uniprot

uniprot Q5ZKI0 396
type: UnificationXref
id: Q5ZKI0
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r38
controller: Ca2+ channel

Glutamate [NMDA] receptor subunit 1
type: ProteinReference
evidence: Evidence 91
xref: uniprot Q24418 134
xref: PTHR18966:SF377
organism: Drosophila melanogaster

uniprot F1PE26 331
type: UnificationXref
id: F1PE26
db: uniprot

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s220 a109 431
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot O70404 223
xref: PTHR45701:SF7
organism: Mus musculus

Protein CBR-SHN-1
type: ProteinReference
xref: uniprot A8WT89 31
xref: PTHR24135:SF18
organism: Caenorhabditis briggsae

uniprot Q71RJ2 20
type: UnificationXref
id: Q71RJ2
db: uniprot

VAMP2 isoform 3
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot H2RCB8 217
organism: Pan troglodytes

GRM2 isoform 3
type: ProteinReference
xref: uniprot H2R892 280
xref: PTHR24060:SF147
organism: Pan troglodytes

Vesicle associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot F6Z5I2 209
organism: Monodelphis domestica

uniprot A2VE57 82
type: UnificationXref
id: A2VE57
db: uniprot

uniprot Q7QI86 183
type: UnificationXref
id: Q7QI86
db: uniprot

uniprot P28652 390
type: UnificationXref
id: P28652
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HPP3 47
xref: PTHR18966:SF351
organism: Macaca mulatta

PTHR18966:SF505
type: RelationshipXref
id: PTHR18966:SF505
db: PANTHER Family
relationship type: By Homology

Calcium/calmodulin-dependent protein kinase type II subunit delta
type: ProteinReference
xref: PTHR24347:SF365
xref: uniprot Q2HJF7 394
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QLH0 189
xref: PTHR12141:SF1
organism: Macaca mulatta

uniprot P22756 87
type: UnificationXref
id: P22756
db: uniprot

Voltage-dependent calcium channel gamma-5 subunit
type: ProteinReference
xref: PTHR12107:SF4
xref: uniprot Q9UF02 23
organism: Homo sapiens

uniprot A0A1D5QLH0 189
type: UnificationXref
id: A0A1D5QLH0
db: uniprot

PTHR18966:SF397
type: RelationshipXref
id: PTHR18966:SF397
db: PANTHER Family
relationship type: By Homology

SH3 and multiple ankyrin repeat domains protein 1
type: ProteinReference
xref: uniprot D3YZU1 35
xref: PTHR24135:SF3
organism: Mus musculus

PTHR18966:SF100
type: RelationshipXref
id: PTHR18966:SF100
db: PANTHER Family
relationship type: By Homology

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 8

uniprot F1QA08 289
type: UnificationXref
id: F1QA08
db: uniprot

TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_r71
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 539
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 538
left: K+
interaction type: TRANSPORT
right: K+

Protein CBR-GLR-6
type: ProteinReference
xref: PTHR18966:SF295
xref: uniprot A8XC86 404
organism: Caenorhabditis briggsae

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF174
xref: uniprot F6YBQ8 67
organism: Macaca mulatta

PTHR11958:SF98
type: RelationshipXref
id: PTHR11958:SF98
db: PANTHER Family
relationship type: By Homology

PTHR11958:SF99
type: RelationshipXref
id: PTHR11958:SF99
db: PANTHER Family
relationship type: By Homology

uniprot O75558 224
type: UnificationXref
id: O75558
db: uniprot

ncbitaxon 559292 229
type: UnificationXref
id: 559292
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BA07 358
xref: PTHR11662:SF207
organism: Bos taurus

PTHR11958:SF97
type: RelationshipXref
id: PTHR11958:SF97
db: PANTHER Family
relationship type: By Homology

PTHR18966:SF385
type: RelationshipXref
id: PTHR18966:SF385
db: PANTHER Family
relationship type: By Homology

uniprot Q10901 179
type: UnificationXref
id: Q10901
db: uniprot

PTHR18966:SF382
type: RelationshipXref
id: PTHR18966:SF382
db: PANTHER Family
relationship type: By Homology

uniprot Q9W1I8 270
type: UnificationXref
id: Q9W1I8
db: uniprot

PTHR11958:SF93
type: RelationshipXref
id: PTHR11958:SF93
db: PANTHER Family
relationship type: By Homology

uniprot H2QMZ0 215
type: UnificationXref
id: H2QMZ0
db: uniprot

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF97
xref: uniprot F1PUW7 152
organism: Canis lupus familiaris

Glutamate ionotropic receptor NMDA type subunit 3A
type: ProteinReference
evidence: Evidence 91
evidence: Evidence 117
xref: PTHR18966:SF397
xref: uniprot E1BK87 118
organism: Bos taurus

PTHR18966:SF377
type: RelationshipXref
id: PTHR18966:SF377
db: PANTHER Family
relationship type: By Homology

SNARE Complex
type: Protein
entity reference: SNARE Complex
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 419
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

Excitatory amino acid transporter 3
type: ProteinReference
xref: uniprot F7H624 161
xref: PTHR11958:SF97
organism: Macaca mulatta

uniprot P39087 77
type: UnificationXref
id: P39087
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot O95721 225
organism: Homo sapiens

Vesicular glutamate transporter 2
type: ProteinReference
xref: uniprot Q8BLE7 370
xref: PTHR11662:SF201
organism: Mus musculus

SH3 and multiple ankyrin repeat domains protein 3
type: ProteinReference
xref: PTHR24135:SF4
xref: uniprot Q9JLU4 40
organism: Rattus norvegicus

PRKCA-binding protein
type: ProteinReference
xref: PTHR12141:SF1
xref: uniprot F1N6J2 191
organism: Bos taurus

uniprot Q12879 103
type: UnificationXref
id: Q12879
db: uniprot

PSD95
type: Protein
entity reference: PSD95
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa14 443
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

DISSOCIATION
type: RelationshipTypeVocabulary

uniprot P18489 226
type: UnificationXref
id: P18489
db: uniprot

PTHR18966:SF370
type: RelationshipXref
id: PTHR18966:SF370
db: PANTHER Family
relationship type: By Homology

uniprot P42261 329
type: UnificationXref
id: P42261
db: uniprot

Si:dkey-183j2.10
type: ProteinReference
xref: uniprot E7F5R2 405
xref: PTHR18966:SF417
organism: Danio rerio

a152_degraded
type: PhysicalEntity
cellular location: lysosome
comment: SPECIES_TYPE=DEGRADED

uniprot Q3MHJ9 395
type: UnificationXref
id: Q3MHJ9
db: uniprot

uniprot A0A1D5QGY4 375
type: UnificationXref
id: A0A1D5QGY4
db: uniprot

Metabotropic glutamate receptor 2
type: ProteinReference
xref: uniprot P31421 281
xref: PTHR24060:SF147
organism: Rattus norvegicus

Metabotropic glutamate receptor 3
type: ProteinReference
xref: uniprot P31422 282
xref: PTHR24060:SF160
organism: Rattus norvegicus

uniprot O44419 221
type: UnificationXref
id: O44419
db: uniprot

PARTICIPANT STOICHIOMETRY r104 488
type: Stoichiometry
physical entity: a151_degraded
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r104 487
type: Stoichiometry
physical entity: AMPA
stoichiometric coefficient: 1.0

PSD95
type: ProteinReference
xref: P00999
comment: ENTITY_REFERENCE_NOTES=Long Name: PSD95 Synonym: DLG4 Accession: P00999
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.PSD95
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Protein shank
member entity reference: SH3 and multiple ankyrin repeat domains protein 2
member entity reference: SH3 and multiple ankyrin repeat domains protein 1
member entity reference: SH3 and multiple ankyrin repeat domains protein 3
member entity reference: Uncharacterized protein
member entity reference: Protein CBR-SHN-1
member entity reference: LD13733p

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF67
xref: uniprot F1Q0W8 153
organism: Canis lupus familiaris

uniprot A0A2I3RPT6 142
type: UnificationXref
id: A0A2I3RPT6
db: uniprot

Glutamate ionotropic receptor AMPA type subunit 2
type: ProteinReference
evidence: Evidence 306
xref: PTHR18966:SF99
xref: uniprot F7FY70 312
organism: Ornithorhynchus anatinus

By Homology
type: RelationshipTypeVocabulary

AMPA
type: Protein
entity reference: AMPA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Glu1
type: ProteinReference
xref: P01018
standard name: Glutamate receptor, ionotropic, AMPA 1
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.Glu1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Glutamate receptor, ionotropic, AMPA 1 Synonym: AMPA,AMPA R,GRIA1,glu1,glur1 Accession: P01018
member entity reference: Glutamate receptor IB, isoform B
member entity reference: Glutamate receptor 1
member entity reference: Ionotropic glutamate receptor AMPA 1
member entity reference: GRIA1 isoform 11
member entity reference: Uncharacterized protein
member entity reference: Protein CBR-GLR-1

PTHR18966:SF361
type: RelationshipXref
id: PTHR18966:SF361
db: PANTHER Family
relationship type: By Homology

uniprot Q00168 391
type: UnificationXref
id: Q00168
db: uniprot

uniprot Q60934 89
type: UnificationXref
id: Q60934
db: uniprot

PTHR18966:SF364
type: RelationshipXref
id: PTHR18966:SF364
db: PANTHER Family
relationship type: By Homology

TRANSPORT_LEFT__NMDA-_PSD95-RIGHT__Complex__NMDA_PSD95_-_r122
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r122 469
participant stoichiometry: PARTICIPANT STOICHIOMETRY r122 470
participant stoichiometry: PARTICIPANT STOICHIOMETRY r122 468
left: NMDA
left: PSD95
interaction type: TRANSPORT
right: Complex (NMDA/PSD95)

Ca2+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 187

PTHR18966:SF151
type: RelationshipXref
id: PTHR18966:SF151
db: PANTHER Family
relationship type: By Homology

PTHR18966:SF351
type: RelationshipXref
id: PTHR18966:SF351
db: PANTHER Family
relationship type: By Homology

PTHR18966:SF157
type: RelationshipXref
id: PTHR18966:SF157
db: PANTHER Family
relationship type: By Homology

PTHR18966:SF38
type: RelationshipXref
id: PTHR18966:SF38
db: PANTHER Family
relationship type: By Homology

uniprot O35921 166
type: UnificationXref
id: O35921
db: uniprot

PTHR18966:SF36
type: RelationshipXref
id: PTHR18966:SF36
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot F6YMH2 208
organism: Macaca mulatta

STATE_TRANSITION
type: RelationshipTypeVocabulary

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q9BV40 261
xref: PTHR45701:SF7
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r106 480
type: Stoichiometry
physical entity: NMDA
stoichiometric coefficient: 1.0

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_r58
control type: INHIBITION
controller: cAMP

uniprot A0A2I3SPG5 356
type: UnificationXref
id: A0A2I3SPG5
db: uniprot

PARTICIPANT STOICHIOMETRY r94 500
type: Stoichiometry
physical entity: NR2B
stoichiometric coefficient: 1.0

uniprot Q3T0Y8 247
type: UnificationXref
id: Q3T0Y8
db: uniprot

PARTICIPANT STOICHIOMETRY r94 501
type: Stoichiometry
physical entity: NMDA
stoichiometric coefficient: 1.0

uniprot P83351 241
type: UnificationXref
id: P83351
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A943 210
xref: PTHR45701:SF5
organism: Monodelphis domestica

mGluR 2/3
type: ProteinReference
xref: P01014
standard name: Metabotropic Glutamate Receptor 2 and 3
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.RECEPTOR.mGluR 2/3
comment: ENTITY_REFERENCE_NOTES=Long Name: Metabotropic Glutamate Receptor 2, Metabotropic Glutamate Receptor 3 Synonym: GRM2,GRM3,mGlu 2,mGlu 3,mGlu2,mGlu3,mGluR2,mGluR3 Accession: P01014
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Metabotropic glutamate receptor 3
member entity reference: GRM3 protein
member entity reference: Metabotropic glutamate receptor 2
member entity reference: Uncharacterized protein
member entity reference: Metabotropic glutamate receptor 2 isoform a
member entity reference: Glutamate metabotropic receptor 2
member entity reference: GRM2 isoform 3
member entity reference: GRM3 isoform 1

Soluble NSF attachment protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot P83351 241
organism: Caenorhabditis elegans

Complex (Glu4/Glu3/ Glu2)
type: Complex
component stoichiometry: Glu2 s21 sa20 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glu3 s20 sa19 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glu4 s19 sa18 STOICHIOMETRY ID COMPLEX
component: Glu3
component: Glu2
component: Glu4
feature: COMPLEX BINDING FEATURE s217 a214 416
feature: COMPLEX BINDING FEATURE s217 a214 412
feature: COMPLEX BINDING FEATURE s217 a214 414
cellular location: vesicle

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r69
control type: ACTIVATION
controller: s218

uniprot A0A1D5QIS2 196
type: UnificationXref
id: A0A1D5QIS2
db: uniprot

uniprot P31421 281
type: UnificationXref
id: P31421
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11662:SF207
xref: uniprot F6UIA5 363
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QJC4 28
xref: PTHR24135:SF4
organism: Macaca mulatta

HETERODIMER_ASSOCIATION_LEFT__NR2D-_NR2A-RIGHT__NMDA-_r93
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r93 504
participant stoichiometry: PARTICIPANT STOICHIOMETRY r93 506
participant stoichiometry: PARTICIPANT STOICHIOMETRY r93 505
left: NR2A
left: NR2D
interaction type: HETERODIMER_ASSOCIATION
right: NMDA

uniprot F6SB23 155
type: UnificationXref
id: F6SB23
db: uniprot

uniprot Q9D3G5 262
type: UnificationXref
id: Q9D3G5
db: uniprot

uniprot Q6DEH3 397
type: UnificationXref
id: Q6DEH3
db: uniprot

cAMP
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Metabotropic glutamate receptor 2
type: ProteinReference
xref: uniprot Q14416 283
xref: PTHR24060:SF147
organism: Homo sapiens

uniprot Q24418 134
type: UnificationXref
id: Q24418
db: uniprot

uniprot Q00960 111
type: UnificationXref
id: Q00960
db: uniprot

uniprot Q9WUF4 271
type: UnificationXref
id: Q9WUF4
db: uniprot

PTHR18966:SF527
type: RelationshipXref
id: PTHR18966:SF527
db: PANTHER Family
relationship type: By Homology

PRKCA-binding protein
type: ProteinReference
xref: PTHR12141:SF1
xref: uniprot Q62083 193
organism: Mus musculus

PRKCA-binding protein
type: ProteinReference
xref: PTHR12141:SF1
xref: uniprot Q9NRD5 195
organism: Homo sapiens

Calcium/calmodulin-dependent protein kinase type II subunit delta
type: ProteinReference
xref: PTHR24347:SF365
xref: uniprot Q13557 393
organism: Homo sapiens

PSD95 s15 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PSD95
stoichiometric coefficient: 1.0

Calcium/calmodulin-dependent protein kinase type II subunit beta
type: ProteinReference
xref: PTHR24347:SF403
xref: uniprot Q13554 392
organism: Homo sapiens

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 32

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 34

uniprot Q8VHW4 22
type: UnificationXref
id: Q8VHW4
db: uniprot

Glutamate receptor 3.7
type: ProteinReference
xref: uniprot Q9SDQ4 410
organism: Arabidopsis thaliana

Calcium/calmodulin-dependent protein kinase type II subunit beta
type: ProteinReference
xref: PTHR24347:SF403
xref: uniprot P28652 390
organism: Mus musculus

uniprot P48058 293
type: UnificationXref
id: P48058
db: uniprot

uniprot G3N3K3 129
type: UnificationXref
id: G3N3K3
db: uniprot

uniprot Q5R1P3 114
type: UnificationXref
id: Q5R1P3
db: uniprot

uniprot A0A1D5PIW7 320
type: UnificationXref
id: A0A1D5PIW7
db: uniprot

a151_degraded
type: PhysicalEntity
cellular location: lysosome
comment: SPECIES_TYPE=DEGRADED

s221
type: Complex
component stoichiometry: Glutamate s222 a104 STOICHIOMETRY ID COMPLEX
component stoichiometry: A K s223 a102 STOICHIOMETRY ID COMPLEX
component: Glutamate
component: A/K
feature: COMPLEX BINDING FEATURE s221 csa11 428
feature: COMPLEX BINDING FEATURE s221 csa11 426
cellular location: cytosol

PARTICIPANT STOICHIOMETRY r129 540
type: Stoichiometry
physical entity: AMPA
stoichiometric coefficient: 1.0

uniprot F7FD93 384
type: UnificationXref
id: F7FD93
db: uniprot

PARTICIPANT STOICHIOMETRY r129 541
type: Stoichiometry
physical entity: A/K
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__AMPA-RIGHT__A_K-_r129
controller: stargazin

Calcium/calmodulin-dependent protein kinase type II
type: ProteinReference
xref: uniprot O62305 386
xref: PTHR24347:SF412
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
evidence: Evidence 115
evidence: Evidence 106
evidence: Evidence 92
evidence: Evidence 91
xref: uniprot A0A1D5QE40 96
xref: PTHR18966:SF407
organism: Macaca mulatta

TRANSPORT_LEFT__Na_PLUS_-RIGHT__Na_PLUS_-_r119
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r119 516
participant stoichiometry: PARTICIPANT STOICHIOMETRY r119 517
left: Na+
interaction type: TRANSPORT
right: Na+

uniprot Q14832 284
type: UnificationXref
id: Q14832
db: uniprot

ATP
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

eco ECO:0000501 58
type: UnificationXref
id: ECO:0000501
db: eco

AGAP000028-PA
type: ProteinReference
xref: uniprot Q7QEK3 399
xref: PTHR24347:SF412
organism: Anopheles gambiae

Ca2+
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=ION

Vesicular-fusion protein NsF, putative N-ethylmaleimide sensitive factor (NsF)
type: ProteinReference
xref: uniprot Q4GZ63 348
xref: PTHR23078:SF3
organism: Trypanosoma brucei

uniprot F1PBW6 360
type: UnificationXref
id: F1PBW6
db: uniprot

uniprot F7H624 161
type: UnificationXref
id: F7H624
db: uniprot

Synaptobrevin
type: ProteinReference
xref: PTHR45701:SF10
xref: uniprot P18489 226
organism: Drosophila melanogaster

uniprot A0A2J8KKE8 9
type: UnificationXref
id: A0A2J8KKE8
db: uniprot

Glutamate receptor ionotropic, kainate 2
type: ProteinReference
xref: PTHR18966:SF38
xref: uniprot P42260 78
organism: Rattus norvegicus

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_r71
control type: ACTIVATION
controller: s221

TRANSPORT
type: RelationshipTypeVocabulary

SNAP25 homologous protein SNAP29
type: ProteinReference
xref: uniprot Q9SD96 268
organism: Arabidopsis thaliana

Glutamate receptor, ionotropic, kainate 1b
type: ProteinReference
xref: uniprot A0A286YAY2 402
xref: PTHR18966:SF36
organism: Danio rerio

Syntaxin-11
type: ProteinReference
xref: PTHR19957:SF30
xref: uniprot O75558 224
organism: Homo sapiens

uniprot Q9QX74 41
type: UnificationXref
id: Q9QX74
db: uniprot

NR2C
type: ProteinReference
xref: P01006
standard name: N-methyl D-aspartate receptor subtype 2C
comment: ENTITY_REFERENCE_NOTES=Long Name: N-methyl D-aspartate receptor subtype 2C Synonym: Glutamate [NMDA] receptor subunit epsilon 3,NMDAR2C Accession: P01006
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.NR2C
member entity reference: Glutamate receptor ionotropic, NMDA 2C
member entity reference: Glutamate receptor ionotropic, NMDA 2D
member entity reference: Glutamate receptor ionotropic, NMDA 2A
member entity reference: Glutamate ionotropic receptor NMDA type subunit 2A
member entity reference: Uncharacterized protein

Voltage-dependent calcium channel gamma-5 subunit
type: ProteinReference
xref: uniprot A0A2J8KKE8 9
xref: PTHR12107:SF4
organism: Pan troglodytes

Glutamate receptor 3
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot P42263 303
organism: Homo sapiens

Glutamate receptor ionotropic, kainate 3
type: ProteinReference
xref: PTHR18966:SF174
xref: uniprot P42264 70
organism: Rattus norvegicus

NMDA s14 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NMDA
stoichiometric coefficient: 1.0

A/K
type: Protein
entity reference: A/K
feature: COMPLEX PARTICIPANT BINDING FEATURE s223 a102 427
feature: ACTIVE 374
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Glutamate receptor 1
type: ProteinReference
xref: PTHR18966:SF157
xref: uniprot P42261 329
organism: Homo sapiens

uniprot F6Y7R9 311
type: UnificationXref
id: F6Y7R9
db: uniprot

Glutamate receptor 2
type: ProteinReference
evidence: Evidence 306
xref: PTHR18966:SF99
xref: uniprot P42262 317
organism: Homo sapiens

Complex (KA/Glutamate)
type: Complex
component stoichiometry: KA s12 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glutamate s13 sa12 STOICHIOMETRY ID COMPLEX
component: Glutamate
component: KA
feature: COMPLEX BINDING FEATURE s185 a180 452
feature: COMPLEX BINDING FEATURE s185 a180 450
cellular location: axon terminus

Glutamate ionotropic receptor kainate type subunit 2
type: ProteinReference
xref: uniprot F1MG21 73
xref: PTHR18966:SF38
organism: Bos taurus

TRANSPORT_LEFT__AMPA-RIGHT__A_K-_r129
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r129 541
participant stoichiometry: PARTICIPANT STOICHIOMETRY r129 540
left: AMPA
interaction type: TRANSPORT
right: A/K

uniprot P48664 175
type: UnificationXref
id: P48664
db: uniprot

uniprot Q4GZ63 348
type: UnificationXref
id: Q4GZ63
db: uniprot

Synaptosomal-associated protein 25-A
type: ProteinReference
xref: uniprot Q5TZ66 251
xref: PTHR19305:SF5
organism: Danio rerio

uniprot A0A1D5Q6W9 141
type: UnificationXref
id: A0A1D5Q6W9
db: uniprot

uniprot E7F5R2 405
type: UnificationXref
id: E7F5R2
db: uniprot

uniprot A0A452J7P8 403
type: UnificationXref
id: A0A452J7P8
db: uniprot

Glutamate receptor ionotropic, kainate 5
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot Q16478 48
organism: Homo sapiens

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A5PEW5 199
xref: PTHR19305:SF14
organism: Caenorhabditis elegans

uniprot Q94392 353
type: UnificationXref
id: Q94392
db: uniprot

ncbitaxon 9598 10
type: UnificationXref
id: 9598
db: ncbitaxon

KA2
type: ProteinReference
xref: P01003
standard name: Glutamate receptor, ionotropic kainate 2
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.KA2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Glutamate receptor, ionotropic kainate 2 Synonym: EAA4,Excitatory amino acid receptor 4,GRIK2,GluR-6,GluR6,Glutamate receptor 6 Accession: P01003
member entity reference: Glutamate receptor ionotropic, kainate 2
member entity reference: Uncharacterized protein
member entity reference: Glutamate ionotropic receptor kainate type subunit 2
member entity reference: GRIK2 isoform 3

uniprot F7A943 210
type: UnificationXref
id: F7A943
db: uniprot

Glutamate ionotropic receptor AMPA type subunit 4
type: ProteinReference
xref: PTHR18966:SF100
xref: uniprot F6YN64 290
organism: Monodelphis domestica

uniprot Q00961 101
type: UnificationXref
id: Q00961
db: uniprot

PTHR24135:SF3
type: RelationshipXref
id: PTHR24135:SF3
db: PANTHER Family
relationship type: By Homology

uniprot P63045 240
type: UnificationXref
id: P63045
db: uniprot

ncbitaxon 10090 19
type: UnificationXref
id: 10090
db: ncbitaxon

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 11

uniprot P60878 232
type: UnificationXref
id: P60878
db: uniprot

Solute carrier family 17 member 8
type: ProteinReference
xref: uniprot A0A2I3SPG5 356
xref: PTHR11662:SF207
organism: Pan troglodytes

uniprot F7AF72 300
type: UnificationXref
id: F7AF72
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F6UBJ8 205
xref: PTHR19305:SF4
organism: Xenopus tropicalis

KA
type: ProteinReference
xref: P01026
standard name: Kainate Receptor
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.ION_CHANNEL.KA
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES=Long Name: Kainate Receptor Synonym: Synonym not specified Accession: P01026
member entity reference: Glutamate receptor ionotropic, kainate 1
member entity reference: Probable glutamate receptor
member entity reference: Glutamate receptor, ionotropic, kainate 1b
member entity reference: Glutamate ionotropic receptor kainate type subunit 3
member entity reference: Uncharacterized protein
member entity reference: GRIK3 isoform 1
member entity reference: Glutamate ionotropic receptor kainate type subunit 1
member entity reference: Glutamate receptor ionotropic, kainate 4
member entity reference: Glutamate receptor ionotropic, kainate 2
member entity reference: Glutamate ionotropic receptor kainate type subunit 5
member entity reference: Glutamate receptor ionotropic, kainate 3
member entity reference: GRIK1 protein
member entity reference: Glutamate receptor ionotropic, kainate 5
member entity reference: GRIK2 isoform 3
member entity reference: GRIK1 isoform 7
member entity reference: Glutamate receptor, ionotropic, kainate 1
member entity reference: Glutamate ionotropic receptor kainate type subunit 2
member entity reference: Glutamate receptor, ionotropic, kainate 5
member entity reference: Si:dkey-183j2.10

uniprot F1Q0W8 153
type: UnificationXref
id: F1Q0W8
db: uniprot

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r69
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 477
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 476
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

uniprot P35436 99
type: UnificationXref
id: P35436
db: uniprot

PTHR24135:SF4
type: RelationshipXref
id: PTHR24135:SF4
db: PANTHER Family
relationship type: By Homology

Vesicular glutamate transporter 3
type: ProteinReference
xref: uniprot Q8BFU8 369
xref: PTHR11662:SF207
organism: Mus musculus

uniprot P63044 239
type: UnificationXref
id: P63044
db: uniprot

mGluR 2 3 s6 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR 2/3
stoichiometric coefficient: 1.0

Calcium/calmodulin-dependent protein kinase type II alpha chain
type: ProteinReference
xref: uniprot Q00168 391
xref: PTHR24347:SF412
organism: Drosophila melanogaster

uniprot F6T423 310
type: UnificationXref
id: F6T423
db: uniprot

PARTICIPANT STOICHIOMETRY r106 479
type: Stoichiometry
physical entity: NR2C
stoichiometric coefficient: 1.0

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 55

PARTICIPANT STOICHIOMETRY r106 478
type: Stoichiometry
physical entity: NR3
stoichiometric coefficient: 1.0

Glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P51906 176
type: UnificationXref
id: P51906
db: uniprot

PARTICIPANT STOICHIOMETRY r133 498
type: Stoichiometry
physical entity: Complex (Glu4/Glu2/ Glu1)
stoichiometric coefficient: 1.0

uniprot H2QQC5 314
type: UnificationXref
id: H2QQC5
db: uniprot

PARTICIPANT STOICHIOMETRY r133 497
type: Stoichiometry
physical entity: Glu4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r131 508
type: Stoichiometry
physical entity: AMPA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r133 496
type: Stoichiometry
physical entity: Glu1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r133 495
type: Stoichiometry
physical entity: Glu2
stoichiometric coefficient: 1.0

Glutamate receptor ionotropic, NMDA 2A
type: ProteinReference
evidence: Evidence 115
evidence: Evidence 106
evidence: Evidence 92
evidence: Evidence 91
xref: PTHR18966:SF407
xref: uniprot P35436 99
organism: Mus musculus

uniprot Q2KJD2 246
type: UnificationXref
id: Q2KJD2
db: uniprot

uniprot A8XC86 404
type: UnificationXref
id: A8XC86
db: uniprot

PTHR18966:SF174
type: RelationshipXref
id: PTHR18966:SF174
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r71 539
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

uniprot E1JHQ6 150
type: UnificationXref
id: E1JHQ6
db: uniprot

PARTICIPANT STOICHIOMETRY r71 538
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

ncbitaxon 367110 347
type: UnificationXref
id: 367110
db: ncbitaxon

PTHR18966:SF171
type: RelationshipXref
id: PTHR18966:SF171
db: PANTHER Family
relationship type: By Homology

RE10813p
type: ProteinReference
xref: uniprot Q8ING5 352
xref: PTHR23078:SF3
organism: Drosophila melanogaster

uniprot P63027 238
type: UnificationXref
id: P63027
db: uniprot

Synaptosomal-associated protein 23
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot O00161 219
organism: Homo sapiens

uniprot F6YEB6 157
type: UnificationXref
id: F6YEB6
db: uniprot

PARTICIPANT STOICHIOMETRY r131 507
type: Stoichiometry
physical entity: Complex (Glu4/Glu2/ Glu1)
stoichiometric coefficient: 1.0

stargazin
type: Protein
entity reference: stargazin
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

KA
type: Protein
entity reference: KA
cellular location: lysosome
comment: SPECIES_TYPE=PROTEIN

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 106
evidence: Evidence 91
xref: uniprot Q13224 113
xref: PTHR18966:SF382
organism: Homo sapiens

P01000
type: UnificationXref
id: P01000
db: PANTHER Pathway Component

Excitatory amino acid transporter 4
type: ProteinReference
xref: uniprot O35544 165
xref: PTHR11958:SF67
organism: Mus musculus

SH3 and multiple ankyrin repeat domains protein 1
type: ProteinReference
xref: uniprot Q9WV48 42
xref: PTHR24135:SF3
organism: Rattus norvegicus

PRKCA-binding protein
type: ProteinReference
xref: PTHR12141:SF1
xref: uniprot Q9EP80 194
organism: Rattus norvegicus

P01004
type: UnificationXref
id: P01004
db: PANTHER Pathway Component

TRANSPORT_LEFT__KA-RIGHT__KA-_r95
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r95 493
participant stoichiometry: PARTICIPANT STOICHIOMETRY r95 494
left: KA
interaction type: TRANSPORT
right: KA

P01003
type: UnificationXref
id: P01003
db: PANTHER Pathway Component

P01002
type: UnificationXref
id: P01002
db: PANTHER Pathway Component

P01001
type: UnificationXref
id: P01001
db: PANTHER Pathway Component

Excitatory amino acid transporter 5
type: ProteinReference
xref: PTHR11958:SF22
xref: uniprot O00341 163
organism: Homo sapiens

uniprot P23763 227
type: UnificationXref
id: P23763
db: uniprot

uniprot P46460 344
type: UnificationXref
id: P46460
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1P0L4 65
xref: PTHR18966:SF174
organism: Gallus gallus

Vesicle associated membrane protein 1
type: ProteinReference
xref: uniprot F1PRG8 202
xref: PTHR45701:SF1
organism: Canis lupus familiaris

ncbitaxon 9258 69
type: UnificationXref
id: 9258
db: ncbitaxon

GO GO:0031982 4
type: UnificationXref
id: GO:0031982
db: GO

uniprot P63024 235
type: UnificationXref
id: P63024
db: uniprot

TRANSPORT_LEFT__Complex__Glu4_Glu2__Glu1_-RIGHT__AMPA-_r127
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r127 546
participant stoichiometry: PARTICIPANT STOICHIOMETRY r127 547
left: Complex (Glu4/Glu2/ Glu1)
interaction type: TRANSPORT
right: AMPA

uniprot Q9BYB0 39
type: UnificationXref
id: Q9BYB0
db: uniprot

Putative proton transport protein
type: ProteinReference
xref: uniprot Q9L0U6 186
organism: Streptomyces coelicolor

uniprot E2RFB5 45
type: UnificationXref
id: E2RFB5
db: uniprot

Glu1 s18 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glu1
stoichiometric coefficient: 1.0

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot Q9ERB0 263
xref: PTHR19305:SF9
organism: Mus musculus

P01011
type: UnificationXref
id: P01011
db: PANTHER Pathway Component

P01010
type: UnificationXref
id: P01010
db: PANTHER Pathway Component

P01013
type: UnificationXref
id: P01013
db: PANTHER Pathway Component

Glu2
type: ProteinReference
xref: P01017
standard name: Glutamate receptor, ionotropic, AMPA 2
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.Glu2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Glutamate receptor, ionotropic, AMPA 2 Synonym: AMPA,AMPA R,GRIA2,glu2,glur2 Accession: P01017
member entity reference: Glutamate receptor 2
member entity reference: GRIA2 isoform 6
member entity reference: Glutamate receptor, ionotropic, AMPA 2a
member entity reference: Glutamate receptor, ionotropic, AMPA 2b
member entity reference: Uncharacterized protein
member entity reference: Glutamate ionotropic receptor AMPA type subunit 2

P01012
type: UnificationXref
id: P01012
db: PANTHER Pathway Component

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF22
xref: uniprot F1MUT8 151
organism: Bos taurus

P01015
type: UnificationXref
id: P01015
db: PANTHER Pathway Component

P01014
type: UnificationXref
id: P01014
db: PANTHER Pathway Component

P01005
type: UnificationXref
id: P01005
db: PANTHER Pathway Component

uniprot P51907 177
type: UnificationXref
id: P51907
db: uniprot

P01006
type: UnificationXref
id: P01006
db: PANTHER Pathway Component

P01007
type: UnificationXref
id: P01007
db: PANTHER Pathway Component

P01008
type: UnificationXref
id: P01008
db: PANTHER Pathway Component

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r38
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 475
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 474
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

P01009
type: UnificationXref
id: P01009
db: PANTHER Pathway Component

uniprot O88602 18
type: UnificationXref
id: O88602
db: uniprot

uniprot P42262 317
type: UnificationXref
id: P42262
db: uniprot

uniprot Q8NDX2 371
type: UnificationXref
id: Q8NDX2
db: uniprot

uniprot Q2HJD2 49
type: UnificationXref
id: Q2HJD2
db: uniprot

PARTICIPANT STOICHIOMETRY r95 493
type: Stoichiometry
physical entity: KA
stoichiometric coefficient: 1.0

uniprot F6PGX6 108
type: UnificationXref
id: F6PGX6
db: uniprot

uniprot F1PXS6 97
type: UnificationXref
id: F1PXS6
db: uniprot

PARTICIPANT STOICHIOMETRY r95 494
type: Stoichiometry
physical entity: KA
stoichiometric coefficient: 1.0

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 106
evidence: Evidence 91
xref: uniprot Q00960 111
xref: PTHR18966:SF382
organism: Rattus norvegicus

Glutamate receptor ionotropic, NMDA 2C
type: ProteinReference
evidence: Evidence 92
evidence: Evidence 91
xref: uniprot Q00961 101
xref: PTHR18966:SF361
organism: Rattus norvegicus

uniprot Q92356 259
type: UnificationXref
id: Q92356
db: uniprot

uniprot Q8BLE7 370
type: UnificationXref
id: Q8BLE7
db: uniprot

P01026
type: UnificationXref
id: P01026
db: PANTHER Pathway Component

Excitatory amino acid transporter 5
type: ProteinReference
xref: PTHR11958:SF22
xref: uniprot Q8JZR4 184
organism: Mus musculus

P01025
type: UnificationXref
id: P01025
db: PANTHER Pathway Component

P01024
type: UnificationXref
id: P01024
db: PANTHER Pathway Component

P01023
type: UnificationXref
id: P01023
db: PANTHER Pathway Component

Glutamate ionotropic receptor NMDA type subunit 3A
type: ProteinReference
evidence: Evidence 91
evidence: Evidence 117
xref: PTHR18966:SF397
xref: uniprot H2QZZ2 121
organism: Pan troglodytes

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 265

P01021
type: UnificationXref
id: P01021
db: PANTHER Pathway Component

P01020
type: UnificationXref
id: P01020
db: PANTHER Pathway Component

Syntaxin-19
type: ProteinReference
xref: PTHR19957:SF29
xref: uniprot Q8R1Q0 258
organism: Mus musculus

ncbitaxon 8364 86
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot F6UFJ7 206
type: UnificationXref
id: F6UFJ7
db: uniprot

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa10 461
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF97
xref: uniprot F6T507 156
organism: Monodelphis domestica

ncbitaxon 7227 30
type: UnificationXref
id: 7227
db: ncbitaxon

Vglut
type: Protein
entity reference: Vglut
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa7 437
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

P01018
type: UnificationXref
id: P01018
db: PANTHER Pathway Component

P01019
type: UnificationXref
id: P01019
db: PANTHER Pathway Component

PTHR45701:SF6
type: RelationshipXref
id: PTHR45701:SF6
db: PANTHER Family
relationship type: By Homology

P01016
type: UnificationXref
id: P01016
db: PANTHER Pathway Component

PTHR45701:SF7
type: RelationshipXref
id: PTHR45701:SF7
db: PANTHER Family
relationship type: By Homology

P01017
type: UnificationXref
id: P01017
db: PANTHER Pathway Component

PTHR45701:SF5
type: RelationshipXref
id: PTHR45701:SF5
db: PANTHER Family
relationship type: By Homology

K+
type: SmallMolecule
comment: SPECIES_TYPE=ION

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF38
xref: uniprot F1NU20 74
organism: Gallus gallus

PTHR45701:SF3
type: RelationshipXref
id: PTHR45701:SF3
db: PANTHER Family
relationship type: By Homology

Glutamate receptor ionotropic, NMDA 2A
type: ProteinReference
evidence: Evidence 115
evidence: Evidence 106
evidence: Evidence 92
evidence: Evidence 91
xref: PTHR18966:SF407
xref: uniprot Q00959 100
organism: Rattus norvegicus

uniprot E2RPE0 190
type: UnificationXref
id: E2RPE0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RJF9 321
xref: PTHR18966:SF157
organism: Macaca mulatta

PTHR45701:SF1
type: RelationshipXref
id: PTHR45701:SF1
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3T3T7 287
type: UnificationXref
id: A0A2I3T3T7
db: uniprot

uniprot Q9N0Y0 266
type: UnificationXref
id: Q9N0Y0
db: uniprot

uniprot H2QZZ2 121
type: UnificationXref
id: H2QZZ2
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 27

uniprot Q17697 332
type: UnificationXref
id: Q17697
db: uniprot

KA
type: Protein
entity reference: KA
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot Q9P7Q4 354
type: UnificationXref
id: Q9P7Q4
db: uniprot

Amino acid transporter
type: ProteinReference
xref: uniprot F6SB23 155
xref: PTHR11958:SF93
organism: Monodelphis domestica

TRANSPORT_LEFT__Complex__Glu4_Glu2__Glu1_-RIGHT__AMPA-_r131
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r131 508
participant stoichiometry: PARTICIPANT STOICHIOMETRY r131 507
left: Complex (Glu4/Glu2/ Glu1)
interaction type: TRANSPORT
right: AMPA

uniprot H2Q995 213
type: UnificationXref
id: H2Q995
db: uniprot

Glutamate receptor, ionotropic, AMPA 2a
type: ProteinReference
evidence: Evidence 306
xref: uniprot A0A0R4ING5 305
xref: PTHR18966:SF99
organism: Danio rerio

KA
type: Protein
entity reference: KA
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa11 451
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q17QQ3 244
xref: PTHR19305:SF5
organism: Bos taurus

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF22
xref: uniprot D3ZT83 148
organism: Rattus norvegicus

uniprot D3YZU1 35
type: UnificationXref
id: D3YZU1
db: uniprot

Glutamate receptor, ionotropic, AMPA 4b
type: ProteinReference
xref: PTHR18966:SF100
xref: uniprot A0A2R8QDR4 288
organism: Danio rerio

uniprot F7CSQ4 159
type: UnificationXref
id: F7CSQ4
db: uniprot

PARTICIPANT STOICHIOMETRY r119 517
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

uniprot Q7ZUC1 256
type: UnificationXref
id: Q7ZUC1
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot Q9N0Y0 266
organism: Macaca mulatta

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot P36975 230
organism: Drosophila melanogaster

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q3T0Y8 247
xref: PTHR45701:SF7
organism: Bos taurus

STATE_TRANSITION_LEFT__KA-RIGHT__a152_degraded-_r105
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r105 481
participant stoichiometry: PARTICIPANT STOICHIOMETRY r105 482
left: KA
interaction type: STATE_TRANSITION
right: a152_degraded

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF22
xref: uniprot F6YEB6 157
organism: Macaca mulatta

uniprot Q9Z2W9 304
type: UnificationXref
id: Q9Z2W9
db: uniprot

STATE_TRANSITION_LEFT__NMDA-RIGHT__a150_degraded-_r102
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r102 502
participant stoichiometry: PARTICIPANT STOICHIOMETRY r102 503
left: NMDA
interaction type: STATE_TRANSITION
right: a150_degraded

uniprot A5D7D8 273
type: UnificationXref
id: A5D7D8
db: uniprot

STATE_TRANSITION_LEFT__AMPA-RIGHT__a151_degraded-_r104
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 488
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 487
left: AMPA
interaction type: STATE_TRANSITION
right: a151_degraded

Vesicle-associated membrane protein 3
type: ProteinReference
xref: uniprot Q15836 243
xref: PTHR45701:SF6
organism: Homo sapiens

uniprot A0A0R4ING5 305
type: UnificationXref
id: A0A0R4ING5
db: uniprot

PARTICIPANT STOICHIOMETRY r119 516
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Glutamate-_A_K-RIGHT__s221-_re40
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 513
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 515
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 514
left: A/K
left: Glutamate
interaction type: HETERODIMER_ASSOCIATION
right: s221

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Na_PLUS_-RIGHT__Na_PLUS_-_r119
control type: ACTIVATION
controller: s218

uniprot A8XJJ7 147
type: UnificationXref
id: A8XJJ7
db: uniprot

uniprot P19491 315
type: UnificationXref
id: P19491
db: uniprot

MGC89708 protein
type: ProteinReference
xref: PTHR19957:SF30
xref: uniprot Q66IG3 254
organism: Xenopus tropicalis

Glutamate
type: SmallMolecule
cellular location: synaptic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

GO GO:0043679 6
type: UnificationXref
id: GO:0043679
db: GO

PSD95
type: Protein
entity reference: PSD95
feature: COMPLEX PARTICIPANT BINDING FEATURE s219 a182 433
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__KA4-_KA5-_KA3-_KA1-_KA2-RIGHT__KA-_r123
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r123 463
participant stoichiometry: PARTICIPANT STOICHIOMETRY r123 462
participant stoichiometry: PARTICIPANT STOICHIOMETRY r123 464
participant stoichiometry: PARTICIPANT STOICHIOMETRY r123 467
participant stoichiometry: PARTICIPANT STOICHIOMETRY r123 466
participant stoichiometry: PARTICIPANT STOICHIOMETRY r123 465
left: KA2
left: KA5
left: KA4
left: KA1
left: KA3
interaction type: HETERODIMER_ASSOCIATION
right: KA

uniprot A2AIR5 116
type: UnificationXref
id: A2AIR5
db: uniprot

Synaptosomal-associated protein 25-B
type: ProteinReference
xref: uniprot Q6PC54 255
xref: PTHR19305:SF5
organism: Danio rerio

Complex (Vglut/Glutamate)
type: Complex
component stoichiometry: Glutamate s9 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: Vglut s8 sa7 STOICHIOMETRY ID COMPLEX
component: Vglut
component: Glutamate
feature: COMPLEX BINDING FEATURE s174 a173 436
feature: COMPLEX BINDING FEATURE s174 a173 438
cellular location: synaptic vesicle

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot O44419 221
xref: PTHR19305:SF14
organism: Strongylocentrotus purpuratus

mGluR 2/3
type: Protein
entity reference: mGluR 2/3
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa5 455
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Excitatory amino acid transporter 1
type: ProteinReference
xref: PTHR11958:SF24
xref: uniprot P24942 168
organism: Rattus norvegicus

Glu2
type: Protein
entity reference: Glu2
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot Q8JZR4 184
type: UnificationXref
id: Q8JZR4
db: uniprot

ACTIVE 374
type: EntityFeature
comment: Active state

Glutamate receptor ionotropic, kainate 5
type: ProteinReference
xref: uniprot Q61626 50
xref: PTHR18966:SF351
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r58 544
type: Stoichiometry
physical entity: Ca2+ channel
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 545
type: Stoichiometry
physical entity: Ca2+ channel
stoichiometric coefficient: 1.0

Excitatory amino acid transporter 4
type: ProteinReference
xref: PTHR11958:SF67
xref: uniprot P48664 175
organism: Homo sapiens

uniprot P46461 345
type: UnificationXref
id: P46461
db: uniprot

Amino acid transporter
type: ProteinReference
xref: uniprot E1JHQ6 150
xref: PTHR11958:SF99
organism: Drosophila melanogaster

uniprot M9PE71 218
type: UnificationXref
id: M9PE71
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q62442 252
xref: PTHR45701:SF1
organism: Mus musculus

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 21

Glutamate ionotropic receptor kainate type subunit 2
type: ProteinReference
xref: uniprot F6TDQ6 75
xref: PTHR18966:SF38
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r75 528
type: Stoichiometry
physical entity: A/K
stoichiometric coefficient: 1.0

Glutamate s7 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r75 527
type: Stoichiometry
physical entity: KA
stoichiometric coefficient: 1.0

Glutamate receptor, ionotropic, AMPA 3b
type: ProteinReference
xref: uniprot A0A286Y9Q6 295
xref: PTHR18966:SF151
organism: Danio rerio

Glutamate receptor ionotropic, NMDA 2C
type: ProteinReference
evidence: Evidence 92
evidence: Evidence 91
xref: PTHR18966:SF361
xref: uniprot Q14957 104
organism: Homo sapiens

eco ECO:0000305 57
type: UnificationXref
id: ECO:0000305
db: eco

CaMKII s5 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CaMKII
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

INHIBITION
type: RelationshipTypeVocabulary

Glutamate receptor ionotropic, kainate 2
type: ProteinReference
xref: PTHR18966:SF38
xref: uniprot Q13002 79
organism: Homo sapiens

Glutamate receptor ionotropic, kainate 3
type: ProteinReference
xref: PTHR18966:SF174
xref: uniprot Q13003 71
organism: Homo sapiens

ncbitaxon 7165 139
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot F6PQH1 154
type: UnificationXref
id: F6PQH1
db: uniprot

uniprot H2QTV4 216
type: UnificationXref
id: H2QTV4
db: uniprot

uniprot Q9VH76 269
type: UnificationXref
id: Q9VH76
db: uniprot

Calcium/calmodulin-dependent protein kinase type II delta chain
type: ProteinReference
xref: uniprot Q5ZKI0 396
xref: PTHR24347:SF365
organism: Gallus gallus

uniprot A0A2I3TR48 322
type: UnificationXref
id: A0A2I3TR48
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__mGluR_2_3-_Glutamate-RIGHT__Complex__mGluR_2_3__Glutamate_-_r109
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r109 473
participant stoichiometry: PARTICIPANT STOICHIOMETRY r109 472
participant stoichiometry: PARTICIPANT STOICHIOMETRY r109 471
left: Glutamate
left: mGluR 2/3
interaction type: HETERODIMER_ASSOCIATION
right: Complex (mGluR 2/3/ Glutamate)

uniprot P31109 228
type: UnificationXref
id: P31109
db: uniprot

PARTICIPANT STOICHIOMETRY r69 477
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot F6TDQ6 75
type: UnificationXref
id: F6TDQ6
db: uniprot

uniprot F1N6J2 191
type: UnificationXref
id: F1N6J2
db: uniprot

PARTICIPANT STOICHIOMETRY r69 476
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

LD03592p
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9W1I8 270
organism: Drosophila melanogaster

NR2B
type: Protein
entity reference: NR2B
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot Q62645 95
type: UnificationXref
id: Q62645
db: uniprot

uniprot E1BEI3 13
type: UnificationXref
id: E1BEI3
db: uniprot

uniprot Q5TZ66 251
type: UnificationXref
id: Q5TZ66
db: uniprot

uniprot Q8MXV8 408
type: UnificationXref
id: Q8MXV8
db: uniprot

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 91
xref: uniprot P35438 131
xref: PTHR18966:SF377
organism: Mus musculus

GO GO:0005829 5
type: UnificationXref
id: GO:0005829
db: GO

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 91
xref: PTHR18966:SF377
xref: uniprot P35439 132
organism: Rattus norvegicus

uniprot C7G3L5 72
type: UnificationXref
id: C7G3L5
db: uniprot

uniprot O00161 219
type: UnificationXref
id: O00161
db: uniprot

ncbitaxon 7668 222
type: UnificationXref
id: 7668
db: ncbitaxon

Putative SNAP25 homologous protein SNAP30
type: ProteinReference
xref: uniprot Q9LMG8 264
organism: Arabidopsis thaliana

KA5
type: ProteinReference
xref: P01000
standard name: Glutamate receptor, ionotropic kainate 5
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.KA5
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Glutamate receptor, ionotropic kainate 5 Synonym: EAA2,Excitatory amino acid receptor 2 Accession: P01000
member entity reference: Glutamate ionotropic receptor kainate type subunit 5
member entity reference: Glutamate receptor ionotropic, kainate 5
member entity reference: Uncharacterized protein
member entity reference: Glutamate receptor, ionotropic, kainate 5

uniprot F7HPP3 47
type: UnificationXref
id: F7HPP3
db: uniprot

GRIN2B isoform 3
type: ProteinReference
evidence: Evidence 106
evidence: Evidence 91
xref: uniprot H2Q5I0 110
xref: PTHR18966:SF382
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r113 530
type: Stoichiometry
physical entity: Vglut
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r113 531
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
evidence: Evidence 306
xref: PTHR18966:SF99
xref: uniprot F6Y7R9 311
organism: Monodelphis domestica

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q0V7N0 242
xref: PTHR45701:SF1
organism: Bos taurus

GRIK1 protein
type: ProteinReference
xref: uniprot A2VE57 82
xref: PTHR18966:SF36
organism: Bos taurus

CaMKII
type: ProteinReference
xref: P01023
standard name: calcium/calmodulin-dependent protein kinase II
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.CaMKII
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Uncharacterized protein
member entity reference: Calcium/calmodulin-dependent protein kinase type II subunit beta
member entity reference: Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
member entity reference: Calcium/calmodulin-dependent protein kinase type II subunit delta
member entity reference: Calcium/calmodulin-dependent protein kinase type II
member entity reference: Calcium/calmodulin-dependent protein kinase type II subunit alpha
member entity reference: Calcium/calmodulin dependent protein kinase II gamma
member entity reference: AGAP000028-PA
member entity reference: Calcium/calmodulin-dependent protein kinase type II delta 1 chain
member entity reference: Calcium/calmodulin-dependent protein kinase type II subunit gamma
member entity reference: Calcium/calmodulin dependent protein kinase II delta
member entity reference: Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta
member entity reference: Calcium/calmodulin-dependent protein kinase type II delta chain
member entity reference: Calcium/calmodulin-dependent protein kinase type II alpha chain
member entity reference: CAMK2A isoform 3

uniprot F7CS79 127
type: UnificationXref
id: F7CS79
db: uniprot

PTHR19957:SF29
type: RelationshipXref
id: PTHR19957:SF29
db: PANTHER Family
relationship type: By Homology

uniprot P56564 178
type: UnificationXref
id: P56564
db: uniprot

uniprot O77062 167
type: UnificationXref
id: O77062
db: uniprot

Complex (Glu4/Glu2/ Glu1)
type: Complex
component stoichiometry: Glu1 s18 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glu4 s16 sa15 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glu2 s17 sa16 STOICHIOMETRY ID COMPLEX
component: Glu2
component: Glu4
component: Glu1
feature: COMPLEX BINDING FEATURE s212 a209 448
feature: COMPLEX BINDING FEATURE s212 a209 444
feature: COMPLEX BINDING FEATURE s212 a209 446
cellular location: vesicle

uniprot Q9P2U8 373
type: UnificationXref
id: Q9P2U8
db: uniprot

KA
type: Protein
entity reference: KA
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot F6V5G0 276
type: UnificationXref
id: F6V5G0
db: uniprot

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa6 457
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR19957:SF30
type: RelationshipXref
id: PTHR19957:SF30
db: PANTHER Family
relationship type: By Homology

uniprot D7RVR6 149
type: UnificationXref
id: D7RVR6
db: uniprot

Voltage-dependent calcium channel gamma-2 subunit
type: ProteinReference
xref: uniprot Q9Y698 25
organism: Homo sapiens

Glutamate ionotropic receptor AMPA type subunit 2
type: ProteinReference
xref: PTHR18966:SF99
xref: uniprot F1PE26 331
organism: Canis lupus familiaris

uniprot Q14BI2 285
type: UnificationXref
id: Q14BI2
db: uniprot

uniprot Q9JLU4 40
type: UnificationXref
id: Q9JLU4
db: uniprot

Excitatory amino acid transporter 3
type: ProteinReference
xref: PTHR11958:SF97
xref: uniprot Q95135 185
organism: Bos taurus

uniprot F6T507 156
type: UnificationXref
id: F6T507
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QIS2 196
xref: PTHR45701:SF7
organism: Macaca mulatta

uniprot F7FKB2 160
type: UnificationXref
id: F7FKB2
db: uniprot

uniprot F6UMW2 364
type: UnificationXref
id: F6UMW2
db: uniprot

uniprot G0T3G6 325
type: UnificationXref
id: G0T3G6
db: uniprot

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa8 439
cellular location: synaptic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

GRIA3 isoform 2
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot A0A2J8LE31 296
organism: Pan troglodytes

AGAP000801-PB (Fragment)
type: ProteinReference
xref: PTHR18966:SF370
xref: uniprot F5HJZ1 406
organism: Anopheles gambiae

Metabotropic glutamate receptor 2 isoform a
type: ProteinReference
xref: uniprot F7H091 278
xref: PTHR24060:SF147
organism: Macaca mulatta

uniprot Q01097 112
type: UnificationXref
id: Q01097
db: uniprot

EAAT
type: ProteinReference
xref: P01011
standard name: excitatory amino acid transporter
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.EAAT
comment: ENTITY_REFERENCE_NOTES=Long Name: excitatory amino acid transporter Synonym: EAAT1,GLAST1,GLT-1 Accession: P01011
member entity reference: Amino acid transporter
member entity reference: Putative sodium-dependent excitatory amino acid transporter glt-4
member entity reference: Excitatory amino acid transporter 1
member entity reference: Excitatory amino acid transporter 2
member entity reference: Excitatory amino acid transporter 4
member entity reference: Excitatory amino acid transporter 3
member entity reference: Amino acid transporter (Fragment)
member entity reference: Excitatory amino acid transporter 5
member entity reference: Excitatory amino acid transporter
member entity reference: Putative proton transport protein

GRIA2 isoform 6
type: ProteinReference
evidence: Evidence 306
xref: uniprot H2QQC5 314
xref: PTHR18966:SF99
organism: Pan troglodytes

ncbitaxon 10116 21
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot Q2HJF7 394
type: UnificationXref
id: Q2HJF7
db: uniprot

uniprot A0A2I3STB7 376
type: UnificationXref
id: A0A2I3STB7
db: uniprot

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

NMDA
type: Protein
entity reference: NMDA
cellular location: lysosome
comment: SPECIES_TYPE=PROTEIN

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot H2Q995 213
xref: PTHR19305:SF4
organism: Pan troglodytes

uniprot Q13003 71
type: UnificationXref
id: Q13003
db: uniprot

Glutamate receptor ionotropic, NMDA 2D
type: ProteinReference
evidence: Evidence 92
evidence: Evidence 91
evidence: Evidence 93
xref: uniprot Q03391 94
xref: PTHR18966:SF385
organism: Mus musculus

Calcium/calmodulin-dependent protein kinase type II delta 1 chain
type: ProteinReference
xref: uniprot Q6DEH3 397
xref: PTHR24347:SF365
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR24347:SF365
xref: uniprot F7D2P3 383
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r113 529
type: Stoichiometry
physical entity: Complex (Vglut/Glutamate)
stoichiometric coefficient: 1.0

eco ECO:0000250 11
type: UnificationXref
id: ECO:0000250
db: eco

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 249

uniprot A0A1D5PHB3 80
type: UnificationXref
id: A0A1D5PHB3
db: uniprot

uniprot Q8BFU8 369
type: UnificationXref
id: Q8BFU8
db: uniprot

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF24
xref: uniprot Q6P4V2 182
organism: Danio rerio

uniprot Q05586 133
type: UnificationXref
id: Q05586
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RFB5 45
xref: PTHR18966:SF351
organism: Canis lupus familiaris

uniprot Q7PXM3 138
type: UnificationXref
id: Q7PXM3
db: uniprot

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot A0A2I3SR99 198
xref: PTHR45701:SF7
organism: Pan troglodytes

Glutamate s9 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A0A1D5QYR9 197
xref: PTHR19305:SF4
organism: Macaca mulatta

Glutamate receptor 1
type: ProteinReference
xref: uniprot P34299 328
xref: PTHR18966:SF297
organism: Caenorhabditis elegans

Metabotropic glutamate receptor 3
type: ProteinReference
xref: uniprot Q9QYS2 286
xref: PTHR24060:SF160
organism: Mus musculus

PTHR18966:SF417
type: RelationshipXref
id: PTHR18966:SF417
db: PANTHER Family
relationship type: By Homology

Voltage-dependent calcium channel gamma-2 subunit
type: ProteinReference
xref: uniprot Q71RJ2 20
organism: Rattus norvegicus

Glutamate s222 a104 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

uniprot F1PUW7 152
type: UnificationXref
id: F1PUW7
db: uniprot

NMDA
type: Protein
entity reference: NMDA
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa13 441
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__Complex__NMDA_PSD95_-_Glutamate-RIGHT__s218-_re39
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 550
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 549
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 548
left: Complex (NMDA/PSD95)
left: Glutamate
interaction type: HETERODIMER_ASSOCIATION
right: s218

Glutamate receptor, ionotropic, AMPA 3
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot F7AF72 300
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r115 526
type: Stoichiometry
physical entity: Complex (EAAT/Glutamate)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r115 525
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

uniprot P11730 388
type: UnificationXref
id: P11730
db: uniprot

PARTICIPANT STOICHIOMETRY r115 524
type: Stoichiometry
physical entity: EAAT
stoichiometric coefficient: 1.0

PTHR18966:SF407
type: RelationshipXref
id: PTHR18966:SF407
db: PANTHER Family
relationship type: By Homology

uniprot E1BA07 358
type: UnificationXref
id: E1BA07
db: uniprot

SNARE Complex s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SNARE Complex
stoichiometric coefficient: 1.0

Glu2
type: Protein
entity reference: Glu2
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa16 447
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot F6YLB3 98
type: UnificationXref
id: F6YLB3
db: uniprot

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s222 a104 429
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR18966:SF400
type: RelationshipXref
id: PTHR18966:SF400
db: PANTHER Family
relationship type: By Homology

Complex (SNARE Complex/Ca2+)
type: Complex
component stoichiometry: Ca2 PLUS s2 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: SNARE Complex s1 sa1 STOICHIOMETRY ID COMPLEX
component: SNARE Complex
component: Ca2+
feature: COMPLEX BINDING FEATURE s99 a99 418
feature: COMPLEX BINDING FEATURE s99 a99 420
cellular location: synaptic vesicle

lysosome
type: CellularLocationVocabulary
xref: GO GO:0005764 3

uniprot Q9QUL6 355
type: UnificationXref
id: Q9QUL6
db: uniprot

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF24
xref: uniprot F7CSQ4 159
organism: Xenopus tropicalis

NR2D
type: Protein
entity reference: NR2D
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot Q9S7P9 267
type: UnificationXref
id: Q9S7P9
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 229

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 30

Excitatory amino acid transporter 1
type: ProteinReference
xref: uniprot P46411 174
xref: PTHR11958:SF24
organism: Bos taurus

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF89
xref: uniprot A8XJJ7 147
organism: Caenorhabditis briggsae

Glutamate receptor ionotropic, kainate 5
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot Q63273 51
organism: Rattus norvegicus

uniprot A0A2J8LE31 296
type: UnificationXref
id: A0A2J8LE31
db: uniprot

NMDA
type: ProteinReference
xref: P01024
standard name: N-methyl-D-aspartate Receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.ION_CHANNEL.NMDA
comment: ENTITY_REFERENCE_NOTES=Long Name: N-methyl-D-aspartate Receptor Synonym: NMDA,NMDA Receptor Accession: P01024
member entity reference: Uncharacterized protein
member entity reference: Glutamate receptor ionotropic, NMDA 2D
member entity reference: Glutamate ionotropic receptor NMDA type subunit 3A
member entity reference: Glutamate receptor ionotropic, NMDA 1
member entity reference: Glutamate [NMDA] receptor subunit 1
member entity reference: Glutamate receptor ionotropic, NMDA 2C
member entity reference: Protein CBR-NMR-1
member entity reference: Glutamate receptor ionotropic, NMDA 2A
member entity reference: Glutamate receptor ionotropic, NMDA 3B
member entity reference: NMDA class glutamate Receptor
member entity reference: Glutamate ionotropic receptor NMDA type subunit 1
member entity reference: Glutamate receptor, ionotropic, N-methyl D-aspartate 1b
member entity reference: N-methyl D-aspartate receptor subtype 2B
member entity reference: Glutamate ionotropic receptor NMDA type subunit 2A
member entity reference: Glutamate receptor ionotropic, NMDA 2B
member entity reference: AGAP001478-PA
member entity reference: Glutamate receptor ionotropic, NMDA 3A
member entity reference: Glutamate receptor ionotropic, NMDA3A
member entity reference: N-methyl-D-aspartate receptor type 1 subunit
member entity reference: Glutamate [NMDA] receptor subunit zeta-1 isoform NR1-3
member entity reference: GRIN2B isoform 3
member entity reference: Glutamate receptor, ionotropic, N-methyl D-aspartate 1a

N-ethylmaleimide sensitive factor, vesicle fusing ATPase
type: ProteinReference
xref: uniprot H2QD95 339
xref: PTHR23078:SF3
organism: Pan troglodytes

SH3 and multiple ankyrin repeat domains protein 3
type: ProteinReference
xref: uniprot Q4ACU6 37
xref: PTHR24135:SF4
organism: Mus musculus

uniprot Q5R1X1 250
type: UnificationXref
id: Q5R1X1
db: uniprot

NR2C
type: Protein
entity reference: NR2C
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

Glutamate receptor ionotropic, NMDA 2A
type: ProteinReference
evidence: Evidence 115
evidence: Evidence 106
evidence: Evidence 92
evidence: Evidence 91
xref: PTHR18966:SF407
xref: uniprot Q12879 103
organism: Homo sapiens

KA1
type: Protein
entity reference: KA1
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

Solute carrier family 17 member 8
type: ProteinReference
xref: PTHR11662:SF207
xref: uniprot F6PYA3 361
organism: Ornithorhynchus anatinus

uniprot Q9NRD5 195
type: UnificationXref
id: Q9NRD5
db: uniprot

Excitatory amino acid transporter 3
type: ProteinReference
xref: PTHR11958:SF97
xref: uniprot P43005 172
organism: Homo sapiens

Excitatory amino acid transporter 2
type: ProteinReference
xref: uniprot P43004 171
xref: PTHR11958:SF93
organism: Homo sapiens

Excitatory amino acid transporter 1
type: ProteinReference
xref: PTHR11958:SF24
xref: uniprot P43003 170
organism: Homo sapiens

uniprot F6PYA3 361
type: UnificationXref
id: F6PYA3
db: uniprot

uniprot F6PIV9 337
type: UnificationXref
id: F6PIV9
db: uniprot

Excitatory amino acid transporter 2
type: ProteinReference
xref: uniprot P43006 173
xref: PTHR11958:SF93
organism: Mus musculus

uniprot Q7QE65 407
type: UnificationXref
id: Q7QE65
db: uniprot

uniprot A6QLI1 357
type: UnificationXref
id: A6QLI1
db: uniprot

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 341

NR1
type: Protein
entity reference: NR1
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

PTHR18966:SF422
type: RelationshipXref
id: PTHR18966:SF422
db: PANTHER Family
relationship type: By Homology

Na+
type: SmallMolecule
comment: SPECIES_TYPE=ION

Protein CBR-NMR-1
type: ProteinReference
evidence: Evidence 91
xref: PTHR18966:SF377
xref: uniprot A8WUE7 125
organism: Caenorhabditis briggsae

Syntaxin-19
type: ProteinReference
xref: PTHR19957:SF29
xref: uniprot Q8N4C7 257
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR24135:SF17
xref: uniprot F7BTS3 36
organism: Macaca mulatta

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9Z2P6 272
organism: Rattus norvegicus

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q9WUF4 271
xref: PTHR45701:SF7
organism: Rattus norvegicus

DISSOCIATION_LEFT__Complex__Vglut_Glutamate_-RIGHT__Vglut-_Glutamate-_r113
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r113 529
participant stoichiometry: PARTICIPANT STOICHIOMETRY r113 531
participant stoichiometry: PARTICIPANT STOICHIOMETRY r113 530
left: Complex (Vglut/Glutamate)
interaction type: DISSOCIATION
right: Vglut
right: Glutamate

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q5R1X1 250
xref: PTHR19305:SF5
organism: Pan troglodytes

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r69
control type: ACTIVATION
controller: s221

uniprot F6T3N3 362
type: UnificationXref
id: F6T3N3
db: uniprot

uniprot F6UGY3 381
type: UnificationXref
id: F6UGY3
db: uniprot

uniprot Q5ASG1 248
type: UnificationXref
id: Q5ASG1
db: uniprot

synaptic vesicle
type: CellularLocationVocabulary
xref: GO GO:0008021 2

Uncharacterized protein
type: ProteinReference
evidence: Evidence 91
evidence: Evidence 117
xref: PTHR18966:SF397
xref: uniprot F6VTB5 120
organism: Macaca mulatta

Glutamate receptor ionotropic, kainate 4
type: ProteinReference
xref: PTHR18966:SF171
xref: uniprot Q8BMF5 61
organism: Mus musculus

uniprot E1BAB4 274
type: UnificationXref
id: E1BAB4
db: uniprot

?
type: PhysicalEntity
cellular location: cytosol
comment: SPECIES_TYPE=UNKNOWN

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 86

uniprot P42260 78
type: UnificationXref
id: P42260
db: uniprot

uniprot E1C4A6 15
type: UnificationXref
id: E1C4A6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QGY4 375
xref: PTHR24347:SF403
organism: Macaca mulatta

Glutamate receptor ionotropic, NMDA 3A
type: ProteinReference
evidence: Evidence 91
evidence: Evidence 117
xref: PTHR18966:SF397
xref: uniprot Q8TCU5 122
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR24060:SF160
xref: uniprot E1BUE5 275
organism: Gallus gallus

TRIGGER
type: RelationshipTypeVocabulary

Glutamate receptor ionotropic, kainate 4
type: ProteinReference
xref: uniprot Q01812 56
xref: PTHR18966:SF171
organism: Rattus norvegicus

A/K
type: ProteinReference
xref: P01025
standard name: AMPA/Kainate Receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.ION_CHANNEL.A/K
comment: ENTITY_REFERENCE_NOTES=Long Name: AMPA/Kainate Receptor Synonym: AMPA Receptor,Kainate Receptor Accession: P01025
member entity reference: Glutamate receptor ionotropic, kainate 1
member entity reference: Uncharacterized protein
member entity reference: Glutamate ionotropic receptor AMPA type subunit 4
member entity reference: Glutamate receptor, ionotropic, AMPA 2a
member entity reference: Glutamate receptor, ionotropic, AMPA 3
member entity reference: Glutamate receptor 3
member entity reference: Glutamate ionotropic receptor AMPA type subunit 2
member entity reference: Glutamate ionotropic receptor kainate type subunit 3
member entity reference: Glutamate receptor 2
member entity reference: Glutamate receptor, ionotropic, AMPA 3b
member entity reference: GLutamate Receptor family (AMPA)
member entity reference: Glutamate receptor 1
member entity reference: Glutamate ionotropic receptor kainate type subunit 5
member entity reference: Glutamate receptor IB, isoform B
member entity reference: Ionotropic glutamate receptor AMPA 1
member entity reference: AGAP000801-PB (Fragment)
member entity reference: GRIK1 protein
member entity reference: Glutamate receptor 3.2
member entity reference: Glutamate receptor ionotropic, kainate 5
member entity reference: GRIA2 isoform 6
member entity reference: Glutamate receptor 4
member entity reference: GRIK1 isoform 7
member entity reference: Glutamate ionotropic receptor AMPA type subunit 3
member entity reference: Glutamate receptor, ionotropic, kainate 1
member entity reference: Glutamate receptor ionotropic, kainate 3
member entity reference: Glutamate receptor, ionotropic, AMPA 2b
member entity reference: Glutamate receptor 3.7
member entity reference: Glutamate receptor ionotropic, kainate 2
member entity reference: Probable glutamate receptor
member entity reference: AGAP000803-PA
member entity reference: Glutamate receptor, ionotropic, kainate 1b
member entity reference: GRIA3 isoform 2
member entity reference: GRIK3 isoform 1
member entity reference: Glutamate receptor, ionotropic, AMPA 4a
member entity reference: Glutamate ionotropic receptor kainate type subunit 1
member entity reference: Glutamate receptor ionotropic, kainate 4
member entity reference: Protein CBR-GLR-6
member entity reference: Protein CBR-GLR-1
member entity reference: AGAP006027-PA
member entity reference: GRIK2 isoform 3
member entity reference: Glutamate receptor, ionotropic, AMPA 3a

Glu4
type: ProteinReference
xref: P01015
standard name: Glutamate receptor, ionotropic, AMPA 4
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Glutamate receptor, ionotropic, AMPA 4 Synonym: AMPA,AMPA R,GRIA4,glu4,glur4 Accession: P01015
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.Glu4
member entity reference: Glutamate receptor 4
member entity reference: Glutamate ionotropic receptor AMPA type subunit 4
member entity reference: Uncharacterized protein
member entity reference: Glutamate receptor, ionotropic, AMPA 4a
member entity reference: Glutamate receptor, ionotropic, AMPA 4b

Evidence 91
type: Evidence
evidence code: ISS
comment: Website http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm

uniprot Q9EP80 194
type: UnificationXref
id: Q9EP80
db: uniprot

Evidence 93
type: Evidence
evidence code: ISS
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html

Evidence 92
type: Evidence
evidence code: ISS
comment: Website http://harvester.embl.de/harvester/Q149/Q14957.htm

GRM3 isoform 1
type: ProteinReference
xref: uniprot H2QUV3 279
xref: PTHR24060:SF160
organism: Pan troglodytes

GRIK1 isoform 7
type: ProteinReference
xref: uniprot A0A2I3T979 81
xref: PTHR18966:SF36
organism: Pan troglodytes

N-ethylmaleimide-sensitive fusion protein
type: ProteinReference
xref: uniprot O77313 340
xref: PTHR23078:SF3
organism: Plasmodium falciparum

uniprot Q8VHN2 123
type: UnificationXref
id: Q8VHN2
db: uniprot

uniprot Q15836 243
type: UnificationXref
id: Q15836
db: uniprot

uniprot Q13002 79
type: UnificationXref
id: Q13002
db: uniprot

uniprot P18759 342
type: UnificationXref
id: P18759
db: uniprot

Voltage-dependent calcium channel gamma-5 subunit
type: ProteinReference
xref: PTHR12107:SF4
xref: uniprot E1BEI3 13
organism: Bos taurus

uniprot F7F746 301
type: UnificationXref
id: F7F746
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Complex__Glu4_Glu3__Glu2_-RIGHT__A_K-_r128
controller: NSF

PARTICIPANT STOICHIOMETRY r122 470
type: Stoichiometry
physical entity: Complex (NMDA/PSD95)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r102 503
type: Stoichiometry
physical entity: a150_degraded
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r102 502
type: Stoichiometry
physical entity: NMDA
stoichiometric coefficient: 1.0

uniprot Q80Z38 38
type: UnificationXref
id: Q80Z38
db: uniprot

ncbitaxon 7955 27
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot F6XYX9 207
type: UnificationXref
id: F6XYX9
db: uniprot

A/K
type: Protein
entity reference: A/K
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Glutamate ionotropic receptor NMDA type subunit 2A
type: ProteinReference
evidence: Evidence 115
evidence: Evidence 106
evidence: Evidence 92
evidence: Evidence 91
xref: PTHR18966:SF407
xref: uniprot F6YLB3 98
organism: Monodelphis domestica

uniprot F7H091 278
type: UnificationXref
id: F7H091
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF171
xref: uniprot A0A1D5R2U8 52
organism: Macaca mulatta

uniprot O15399 90
type: UnificationXref
id: O15399
db: uniprot

uniprot E1BUE5 275
type: UnificationXref
id: E1BUE5
db: uniprot

Amino acid transporter
type: ProteinReference
xref: uniprot D7RVR6 149
xref: PTHR11958:SF97
organism: Danio rerio

uniprot Q91ZU9 124
type: UnificationXref
id: Q91ZU9
db: uniprot

Complex (NMDA/PSD95)
type: Complex
component stoichiometry: NMDA s14 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: PSD95 s15 sa14 STOICHIOMETRY ID COMPLEX
component: PSD95
component: NMDA
feature: COMPLEX BINDING FEATURE s189 a186 442
feature: COMPLEX BINDING FEATURE s189 a186 440
cellular location: cytosol

ncbitaxon 185431 349
type: UnificationXref
id: 185431
db: ncbitaxon

PICK s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PICK
stoichiometric coefficient: 1.0

Calcium/calmodulin-dependent protein kinase type II subunit beta
type: ProteinReference
xref: PTHR24347:SF403
xref: uniprot Q3MHJ9 395
organism: Bos taurus

Solute carrier family 17 member 6
type: ProteinReference
xref: PTHR11662:SF201
xref: uniprot F1PBW6 360
organism: Canis lupus familiaris

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot E2QUL2 201
xref: PTHR45701:SF7
organism: Canis lupus familiaris

Glutamate ionotropic receptor NMDA type subunit 3A
type: ProteinReference
evidence: Evidence 91
evidence: Evidence 117
xref: PTHR18966:SF397
xref: uniprot E2QUL1 119
organism: Canis lupus familiaris

PSD95
type: Protein
entity reference: PSD95
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A286YAM5 307
type: UnificationXref
id: A0A286YAM5
db: uniprot

Glutamate ionotropic receptor kainate type subunit 1
type: ProteinReference
xref: uniprot A0A1D5PHB3 80
xref: PTHR18966:SF36
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r122 469
type: Stoichiometry
physical entity: PSD95
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r122 468
type: Stoichiometry
physical entity: NMDA
stoichiometric coefficient: 1.0

uniprot O70404 223
type: UnificationXref
id: O70404
db: uniprot

SNARE Complex
type: Protein
entity reference: SNARE Complex
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot P46459 343
type: UnificationXref
id: P46459
db: uniprot

uniprot A0A1D5R978 334
type: UnificationXref
id: A0A1D5R978
db: uniprot

Complex (EAAT/Glutamate)
type: Complex
component stoichiometry: EAAT s227 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glutamate s11 sa10 STOICHIOMETRY ID COMPLEX
component: EAAT
component: Glutamate
feature: COMPLEX BINDING FEATURE s178 a176 460
feature: COMPLEX BINDING FEATURE s178 a176 458
cellular location: axon terminus

K+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

uniprot F6YBQ8 67
type: UnificationXref
id: F6YBQ8
db: uniprot

uniprot A0A3Q1LSE5 335
type: UnificationXref
id: A0A3Q1LSE5
db: uniprot

uniprot Q9QYS2 286
type: UnificationXref
id: Q9QYS2
db: uniprot

NR2D
type: ProteinReference
xref: P01005
standard name: Glutamate/NMDA receptor epsilon 4 subunit / e 4 subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.NR2D
comment: ENTITY_REFERENCE_NOTES=Long Name: Glutamate/NMDA receptor epsilon 4 subunit / e 4 subunit Synonym: Glutamate/NMDA receptor epsilon 4 subunit / e 4 subunit Accession: P01005
member entity reference: Glutamate receptor ionotropic, NMDA 2D

GLutamate Receptor family (AMPA)
type: ProteinReference
xref: PTHR18966:SF370
xref: uniprot Q17697 332
organism: Caenorhabditis elegans

Vesicle-fusing ATPase
type: ProteinReference
xref: uniprot Q94392 353
xref: PTHR23078:SF3
organism: Caenorhabditis elegans

uniprot O35544 165
type: UnificationXref
id: O35544
db: uniprot

PTHR18966:SF497
type: RelationshipXref
id: PTHR18966:SF497
db: PANTHER Family
relationship type: By Homology

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot Q92356 259
organism: Schizosaccharomyces pombe

uniprot Q16478 48
type: UnificationXref
id: Q16478
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23078:SF3
xref: uniprot A0A3Q1LSE5 335
organism: Bos taurus

uniprot Q17QQ3 244
type: UnificationXref
id: Q17QQ3
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 106
evidence: Evidence 91
xref: uniprot F1NMB0 107
xref: PTHR18966:SF382
organism: Gallus gallus

uniprot F7GR67 128
type: UnificationXref
id: F7GR67
db: uniprot

uniprot A8WT89 31
type: UnificationXref
id: A8WT89
db: uniprot

GO GO:0008021 2
type: UnificationXref
id: GO:0008021
db: GO

EAAT
type: Protein
entity reference: EAAT
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot P63026 237
type: UnificationXref
id: P63026
db: uniprot

Calcium/calmodulin dependent protein kinase II gamma
type: ProteinReference
xref: uniprot A0A2I3TUE7 378
xref: PTHR24347:SF398
organism: Pan troglodytes

Amino acid transporter
type: ProteinReference
xref: uniprot A0A0R4IFU7 140
xref: PTHR11958:SF93
organism: Danio rerio

uniprot Q1K5G2 346
type: UnificationXref
id: Q1K5G2
db: uniprot

Glutamate receptor ionotropic, NMDA 2C
type: ProteinReference
evidence: Evidence 92
evidence: Evidence 91
xref: uniprot Q01098 102
xref: PTHR18966:SF361
organism: Mus musculus

Bos taurus
type: BioSource
xref: ncbitaxon 9913 14

PARTICIPANT STOICHIOMETRY r112 532
type: Stoichiometry
physical entity: Vglut
stoichiometric coefficient: 1.0

uniprot F7BDN8 85
type: UnificationXref
id: F7BDN8
db: uniprot

PTHR18966:SF488
type: RelationshipXref
id: PTHR18966:SF488
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r112 533
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

CAMK2A isoform 3
type: ProteinReference
xref: uniprot A0A2I3STB7 376
xref: PTHR24347:SF384
organism: Pan troglodytes

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 106
evidence: Evidence 91
xref: uniprot Q01097 112
xref: PTHR18966:SF382
organism: Mus musculus

uniprot F1P0L4 65
type: UnificationXref
id: F1P0L4
db: uniprot

PARTICIPANT STOICHIOMETRY r112 534
type: Stoichiometry
physical entity: Complex (Vglut/Glutamate)
stoichiometric coefficient: 1.0

uniprot Q9SD96 268
type: UnificationXref
id: Q9SD96
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BQU4 336
xref: PTHR23078:SF3
organism: Gallus gallus

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 69

KA s12 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: KA
stoichiometric coefficient: 1.0

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa12 453
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 58

Glutamate receptor, ionotropic, AMPA 2b
type: ProteinReference
evidence: Evidence 306
xref: PTHR18966:SF99
xref: uniprot A0A286YAM5 307
organism: Danio rerio

ncbitaxon 6238 32
type: UnificationXref
id: 6238
db: ncbitaxon

ncbitaxon 3702 265
type: UnificationXref
id: 3702
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YX10 365
xref: PTHR11662:SF201
organism: Monodelphis domestica

Amino acid transporter
type: ProteinReference
xref: uniprot H2R6U6 162
xref: PTHR11958:SF97
organism: Pan troglodytes

Glu4
type: Protein
entity reference: Glu4
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa18 413
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

Glutamate receptor ionotropic, NMDA 2D
type: ProteinReference
evidence: Evidence 92
evidence: Evidence 91
evidence: Evidence 93
xref: PTHR18966:SF385
xref: uniprot O15399 90
organism: Homo sapiens

KA4
type: Protein
entity reference: KA4
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

Amino acid transporter
type: ProteinReference
xref: uniprot O18210 164
organism: Caenorhabditis elegans

uniprot Q01098 102
type: UnificationXref
id: Q01098
db: uniprot

Metabotropic glutamate receptor 2
type: ProteinReference
xref: PTHR24060:SF147
xref: uniprot Q14BI2 285
organism: Mus musculus

uniprot Q93YT1 409
type: UnificationXref
id: Q93YT1
db: uniprot

uniprot F7ANC6 68
type: UnificationXref
id: F7ANC6
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__NR3-_NR2C-RIGHT__NMDA-_r106
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r106 479
participant stoichiometry: PARTICIPANT STOICHIOMETRY r106 480
participant stoichiometry: PARTICIPANT STOICHIOMETRY r106 478
left: NR2C
left: NR3
interaction type: HETERODIMER_ASSOCIATION
right: NMDA

Uncharacterized protein
type: ProteinReference
xref: PTHR24347:SF365
xref: uniprot F6UGY3 381
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FB74 54
xref: PTHR18966:SF171
organism: Monodelphis domestica

Complex (mGluR 2/3/ Glutamate)
type: Complex
component stoichiometry: Glutamate s7 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: mGluR 2 3 s6 sa5 STOICHIOMETRY ID COMPLEX
component: mGluR 2/3
component: Glutamate
feature: COMPLEX BINDING FEATURE s169 a167 456
feature: COMPLEX BINDING FEATURE s169 a167 454
cellular location: axon terminus

uniprot Q61626 50
type: UnificationXref
id: Q61626
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 46

Glutamate receptor ionotropic, kainate 4
type: ProteinReference
xref: PTHR18966:SF171
xref: uniprot Q5IS46 60
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r93 505
type: Stoichiometry
physical entity: NR2A
stoichiometric coefficient: 1.0

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 421
cellular location: synaptic vesicle
comment: SPECIES_TYPE=ION

PARTICIPANT STOICHIOMETRY r93 506
type: Stoichiometry
physical entity: NMDA
stoichiometric coefficient: 1.0

uniprot P36975 230
type: UnificationXref
id: P36975
db: uniprot

PARTICIPANT STOICHIOMETRY r93 504
type: Stoichiometry
physical entity: NR2D
stoichiometric coefficient: 1.0

VAMP3 isoform 1
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot G2HIJ9 211
organism: Pan troglodytes

uniprot Q5IS46 60
type: UnificationXref
id: Q5IS46
db: uniprot

PTHR45701:SF10
type: RelationshipXref
id: PTHR45701:SF10
db: PANTHER Family
relationship type: By Homology

Calcium/calmodulin-dependent protein kinase type II subunit gamma
type: ProteinReference
xref: PTHR24347:SF398
xref: uniprot P11730 388
organism: Rattus norvegicus

Glutamate ionotropic receptor kainate type subunit 1
type: ProteinReference
xref: uniprot F6S5B1 83
xref: PTHR18966:SF36
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r109 472
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r109 471
type: Stoichiometry
physical entity: mGluR 2/3
stoichiometric coefficient: 1.0

uniprot A0A1D5R2B1 7
type: UnificationXref
id: A0A1D5R2B1
db: uniprot

PARTICIPANT STOICHIOMETRY r109 473
type: Stoichiometry
physical entity: Complex (mGluR 2/3/ Glutamate)
stoichiometric coefficient: 1.0

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 16

Excitatory amino acid transporter 2
type: ProteinReference
xref: PTHR11958:SF93
xref: uniprot P31596 169
organism: Rattus norvegicus

Glutamate ionotropic receptor AMPA type subunit 3
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot F6TYP9 299
organism: Ornithorhynchus anatinus

PTHR11662:SF201
type: RelationshipXref
id: PTHR11662:SF201
db: PANTHER Family
relationship type: By Homology

Protein CBR-GLR-1
type: ProteinReference
xref: uniprot A8XT20 323
xref: PTHR18966:SF297
organism: Caenorhabditis briggsae

PTHR11662:SF207
type: RelationshipXref
id: PTHR11662:SF207
db: PANTHER Family
relationship type: By Homology

uniprot F5HJZ1 406
type: UnificationXref
id: F5HJZ1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R978 334
xref: PTHR23078:SF3
organism: Macaca mulatta

TRANSPORT_LEFT__NMDA-RIGHT__NMDA-_r97
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r97 485
participant stoichiometry: PARTICIPANT STOICHIOMETRY r97 486
left: NMDA
interaction type: TRANSPORT
right: NMDA

Glutamate receptor ionotropic, kainate 3
type: ProteinReference
xref: PTHR18966:SF174
xref: uniprot B1AS29 63
organism: Mus musculus

uniprot Q8N4C7 257
type: UnificationXref
id: Q8N4C7
db: uniprot

uniprot F1QX22 203
type: UnificationXref
id: F1QX22
db: uniprot

NMDA
type: Protein
entity reference: NMDA
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

Glutamate receptor ionotropic, NMDA 2D
type: ProteinReference
evidence: Evidence 92
evidence: Evidence 91
evidence: Evidence 93
xref: uniprot Q62645 95
xref: PTHR18966:SF385
organism: Rattus norvegicus

uniprot P43003 170
type: UnificationXref
id: P43003
db: uniprot

Glu3 s20 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glu3
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PIV9 337
xref: PTHR23078:SF3
organism: Xenopus tropicalis

P00999
type: UnificationXref
id: P00999
db: PANTHER Pathway Component

P00998
type: UnificationXref
id: P00998
db: PANTHER Pathway Component

uniprot P60880 234
type: UnificationXref
id: P60880
db: uniprot

SNAP25 homologous protein SNAP33
type: ProteinReference
xref: uniprot Q9S7P9 267
organism: Arabidopsis thaliana

GRIK3 isoform 1
type: ProteinReference
xref: uniprot C7G3L6 64
xref: PTHR18966:SF174
organism: Pan troglodytes

GRIK2 isoform 3
type: ProteinReference
xref: PTHR18966:SF38
xref: uniprot C7G3L5 72
organism: Pan troglodytes

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot Q9VH76 269
organism: Drosophila melanogaster

Glutamate receptor 3
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot P19492 302
organism: Rattus norvegicus

Glutamate receptor 4
type: ProteinReference
xref: PTHR18966:SF100
xref: uniprot P19493 292
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION_LEFT__Glu2-_Glu1-_Glu4-RIGHT__Complex__Glu4_Glu2__Glu1_-_r133
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r133 495
participant stoichiometry: PARTICIPANT STOICHIOMETRY r133 496
participant stoichiometry: PARTICIPANT STOICHIOMETRY r133 497
participant stoichiometry: PARTICIPANT STOICHIOMETRY r133 498
left: Glu4
left: Glu1
left: Glu2
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Glu4/Glu2/ Glu1)

Glutamate receptor 2
type: ProteinReference
evidence: Evidence 306
xref: PTHR18966:SF99
xref: uniprot P19491 315
organism: Rattus norvegicus

Evidence 106
type: Evidence
evidence code: ISS
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html

Uncharacterized protein
type: ProteinReference
evidence: Evidence 306
xref: PTHR18966:SF99
xref: uniprot F1NKF1 309
organism: Gallus gallus

Glutamate receptor, ionotropic, N-methyl D-aspartate 1a
type: ProteinReference
evidence: Evidence 91
xref: uniprot E7F101 126
xref: PTHR18966:SF400
organism: Danio rerio

uniprot P63025 236
type: UnificationXref
id: P63025
db: uniprot

N-methyl-D-aspartate receptor type 1 subunit
type: ProteinReference
evidence: Evidence 91
xref: uniprot Q6R6I2 136
xref: PTHR18966:SF377
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot E1C2Q1 53
xref: PTHR18966:SF171
organism: Gallus gallus

Glutamate receptor 4
type: ProteinReference
xref: PTHR18966:SF100
xref: uniprot P48058 293
organism: Homo sapiens

Glutamate receptor, ionotropic, kainate 1
type: ProteinReference
xref: uniprot F7BDN8 85
xref: PTHR18966:SF36
organism: Xenopus tropicalis

uniprot P43005 172
type: UnificationXref
id: P43005
db: uniprot

Solute carrier family 17 member 8
type: ProteinReference
xref: PTHR11662:SF207
xref: uniprot E2RDG5 359
organism: Canis lupus familiaris

uniprot Q16099 59
type: UnificationXref
id: Q16099
db: uniprot

Glu2
type: Protein
entity reference: Glu2
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa20 417
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r94 499
type: Stoichiometry
physical entity: NR1
stoichiometric coefficient: 1.0

NR3
type: ProteinReference
xref: P01009
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.NR3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: NR3 Synonym: NMDAR-L Accession: P01009
member entity reference: Glutamate ionotropic receptor NMDA type subunit 3A
member entity reference: Uncharacterized protein
member entity reference: Glutamate receptor ionotropic, NMDA 3B
member entity reference: Glutamate receptor ionotropic, NMDA 3A
member entity reference: Glutamate receptor ionotropic, NMDA3A

uniprot Q9N280 188
type: UnificationXref
id: Q9N280
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__SNARE_Complex-_Ca2_PLUS_-RIGHT__Complex__SNARE_Complex_Ca2_PLUS__-_r111
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r111 536
participant stoichiometry: PARTICIPANT STOICHIOMETRY r111 535
participant stoichiometry: PARTICIPANT STOICHIOMETRY r111 537
left: SNARE Complex
left: Ca2+
interaction type: HETERODIMER_ASSOCIATION
right: Complex (SNARE Complex/Ca2+)

uniprot Q9SDQ4 410
type: UnificationXref
id: Q9SDQ4
db: uniprot

ncbitaxon 6239 34
type: UnificationXref
id: 6239
db: ncbitaxon

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re41
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 511
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 512
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

uniprot G2HIJ9 211
type: UnificationXref
id: G2HIJ9
db: uniprot

uniprot Q75JI3 350
type: UnificationXref
id: Q75JI3
db: uniprot

EAAT
type: Protein
entity reference: EAAT
feature: COMPLEX PARTICIPANT BINDING FEATURE s227 sa9 459
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Syntaxin 11a
type: ProteinReference
xref: uniprot F1QX22 203
xref: PTHR19957:SF30
organism: Danio rerio

Glutamate s220 a109 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Calcium/calmodulin dependent protein kinase II delta
type: ProteinReference
xref: uniprot A0A2I3TH19 377
xref: PTHR24347:SF365
organism: Pan troglodytes

Evidence 117
type: Evidence
evidence code: ISS
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html

uniprot P31422 282
type: UnificationXref
id: P31422
db: uniprot

Evidence 115
type: Evidence
evidence code: ISS
comment: Website http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436

Uncharacterized protein
type: ProteinReference
evidence: Evidence 106
evidence: Evidence 91
xref: PTHR18966:SF382
xref: uniprot F1MCL3 105
organism: Bos taurus

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF93
xref: uniprot A0A2I3RPT6 142
organism: Pan troglodytes

Glutamate receptor 3.2
type: ProteinReference
xref: PTHR18966:SF422
xref: uniprot Q93YT1 409
organism: Arabidopsis thaliana

uniprot K9J7V0 385
type: UnificationXref
id: K9J7V0
db: uniprot

uniprot F7D2P3 383
type: UnificationXref
id: F7D2P3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF370
xref: uniprot Q9VDH5 411
organism: Drosophila melanogaster

ncbitaxon 13616 55
type: UnificationXref
id: 13616
db: ncbitaxon

mGluR 2/3
type: Protein
entity reference: mGluR 2/3
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

NMDA
type: Protein
entity reference: NMDA
feature: ACTIVE 374
feature: COMPLEX PARTICIPANT BINDING FEATURE s107 a103 435
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q28HP6 245
type: UnificationXref
id: Q28HP6
db: uniprot

UNKNOWN_CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__KA-RIGHT__A_K-_r75
controller: ?

Glutamate receptor, ionotropic, N-methyl D-aspartate 1b
type: ProteinReference
evidence: Evidence 91
xref: PTHR18966:SF497
xref: uniprot Q6ZM67 137
organism: Danio rerio

uniprot Q923T9 400
type: UnificationXref
id: Q923T9
db: uniprot

Protein interacting with PRKCA 1
type: ProteinReference
xref: PTHR12141:SF1
xref: uniprot H2QLN1 192
organism: Pan troglodytes

Vesicle-fusing ATPase
type: ProteinReference
xref: uniprot P46459 343
xref: PTHR23078:SF3
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r116 523
type: Stoichiometry
physical entity: EAAT
stoichiometric coefficient: 1.0

uniprot Q03445 330
type: UnificationXref
id: Q03445
db: uniprot

uniprot A0A1D5RJF9 321
type: UnificationXref
id: A0A1D5RJF9
db: uniprot

ncbitaxon 9913 14
type: UnificationXref
id: 9913
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r105 481
type: Stoichiometry
physical entity: KA
stoichiometric coefficient: 1.0

uniprot A0A1D5QE40 96
type: UnificationXref
id: A0A1D5QE40
db: uniprot

Glutamate ionotropic receptor kainate type subunit 3
type: ProteinReference
xref: PTHR18966:SF174
xref: uniprot F1PWT6 66
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r116 521
type: Stoichiometry
physical entity: Complex (EAAT/Glutamate)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r116 522
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

uniprot E1C2Q1 53
type: UnificationXref
id: E1C2Q1
db: uniprot

uniprot F6YNZ0 277
type: UnificationXref
id: F6YNZ0
db: uniprot

uniprot F6S5B1 83
type: UnificationXref
id: F6S5B1
db: uniprot

Vesicle-fusing ATPase
type: ProteinReference
xref: uniprot P46460 344
xref: PTHR23078:SF3
organism: Mus musculus

uniprot D3ZT83 148
type: UnificationXref
id: D3ZT83
db: uniprot

Vesicle-fusing ATPase 1
type: ProteinReference
xref: uniprot P46461 345
xref: PTHR23078:SF3
organism: Drosophila melanogaster

Calcium/calmodulin-dependent protein kinase type II subunit alpha
type: ProteinReference
xref: PTHR24347:SF384
xref: uniprot Q9UQM7 401
organism: Homo sapiens

Glutamate receptor 4
type: ProteinReference
xref: PTHR18966:SF100
xref: uniprot Q9Z2W8 294
organism: Mus musculus

Glutamate receptor 3
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot Q9Z2W9 304
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r105 482
type: Stoichiometry
physical entity: a152_degraded
stoichiometric coefficient: 1.0

uniprot O77313 340
type: UnificationXref
id: O77313
db: uniprot

uniprot A8WUE7 125
type: UnificationXref
id: A8WUE7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MKC7 379
xref: PTHR24347:SF384
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F4B9 338
xref: PTHR23078:SF3
organism: Monodelphis domestica

uniprot P19492 302
type: UnificationXref
id: P19492
db: uniprot

uniprot H2QLN1 192
type: UnificationXref
id: H2QLN1
db: uniprot

uniprot P42263 303
type: UnificationXref
id: P42263
db: uniprot

NSF
type: Protein
entity reference: NSF
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6Z5I2 209
type: UnificationXref
id: F6Z5I2
db: uniprot

Calcium/calmodulin-dependent protein kinase type II subunit beta
type: ProteinReference
xref: uniprot P08413 387
xref: PTHR24347:SF403
organism: Rattus norvegicus

uniprot G5EGQ9 130
type: UnificationXref
id: G5EGQ9
db: uniprot

Glutamate receptor 2
type: ProteinReference
evidence: Evidence 319
xref: PTHR18966:SF505
xref: uniprot Q10914 318
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FD93 384
xref: PTHR24347:SF398
organism: Macaca mulatta

KA3
type: ProteinReference
xref: P01002
standard name: Glutamate receptor, ionotropic kainate 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.KA3
comment: ENTITY_REFERENCE_NOTES=Long Name: glutamate receptor, ionotropic, kainate 3 Synonym: EAA5,GLR7,GLUR7,GRIK3,excitatory amino acid receptor 5 Accession: P01002
member entity reference: Glutamate ionotropic receptor kainate type subunit 3
member entity reference: Glutamate receptor ionotropic, kainate 3
member entity reference: Uncharacterized protein
member entity reference: GRIK3 isoform 1

Uncharacterized protein
type: ProteinReference
evidence: Evidence 306
xref: PTHR18966:SF99
xref: uniprot F6T423 310
organism: Xenopus tropicalis

PTHR24347:SF412
type: RelationshipXref
id: PTHR24347:SF412
db: PANTHER Family
relationship type: By Homology

uniprot E7F101 126
type: UnificationXref
id: E7F101
db: uniprot

Ca2+ channel
type: Protein
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot F7AGS3 291
type: UnificationXref
id: F7AGS3
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 139

Glutamate ionotropic receptor kainate type subunit 3
type: ProteinReference
xref: uniprot A0A3Q1M9Y0 62
xref: PTHR18966:SF174
organism: Bos taurus

uniprot A0A2R8QDR4 288
type: UnificationXref
id: A0A2R8QDR4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YNZ0 277
xref: PTHR24060:SF160
organism: Macaca mulatta

uniprot E1BK87 118
type: UnificationXref
id: E1BK87
db: uniprot

A K s223 a102 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: A/K
stoichiometric coefficient: 1.0

uniprot A8XT20 323
type: UnificationXref
id: A8XT20
db: uniprot

uniprot P42264 70
type: UnificationXref
id: P42264
db: uniprot

uniprot F6T8S6 109
type: UnificationXref
id: F6T8S6
db: uniprot

Syntaxin-11
type: ProteinReference
xref: uniprot Q9D3G5 262
xref: PTHR19957:SF30
organism: Mus musculus

PTHR24347:SF403
type: RelationshipXref
id: PTHR24347:SF403
db: PANTHER Family
relationship type: By Homology

uniprot F7BTS3 36
type: UnificationXref
id: F7BTS3
db: uniprot

uniprot F6VTB5 120
type: UnificationXref
id: F6VTB5
db: uniprot

Glu4
type: Protein
entity reference: Glu4
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot F1MUT8 151
type: UnificationXref
id: F1MUT8
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot A8X8S6 200
organism: Caenorhabditis briggsae

Glutamate ionotropic receptor NMDA type subunit 1
type: ProteinReference
evidence: Evidence 91
xref: PTHR18966:SF377
xref: uniprot G3N3K3 129
organism: Bos taurus

Glutamate receptor ionotropic, kainate 1
type: ProteinReference
xref: uniprot P39086 88
xref: PTHR18966:SF36
organism: Homo sapiens

uniprot P39086 88
type: UnificationXref
id: P39086
db: uniprot

PARTICIPANT STOICHIOMETRY re41 512
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

PTHR18966:SF297
type: RelationshipXref
id: PTHR18966:SF297
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF157
xref: uniprot A0A1D5PIW7 320
organism: Gallus gallus

uniprot A0A1D5QJC4 28
type: UnificationXref
id: A0A1D5QJC4
db: uniprot

Glutamate receptor ionotropic, kainate 2
type: ProteinReference
xref: uniprot P39087 77
xref: PTHR18966:SF38
organism: Mus musculus

PTHR18966:SF295
type: RelationshipXref
id: PTHR18966:SF295
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re41 511
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

KA4
type: ProteinReference
xref: P01001
standard name: Glutamate receptor, ionotropic kainate 4
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.KA4
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: glutamate receptor, ionotropic, kainate 4 Synonym: EAA4,GRIK4,excitatory amino acid receptor 4 Accession: P01001
member entity reference: Uncharacterized protein
member entity reference: Glutamate receptor ionotropic, kainate 4

uniprot P24942 168
type: UnificationXref
id: P24942
db: uniprot

uniprot Q62442 252
type: UnificationXref
id: Q62442
db: uniprot

uniprot O00341 163
type: UnificationXref
id: O00341
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q63666 253
xref: PTHR45701:SF1
organism: Rattus norvegicus

Voltage-dependent calcium channel gamma-2 subunit
type: ProteinReference
xref: uniprot H2QLK9 17
organism: Pan troglodytes

Glutamate receptor ionotropic, kainate 1
type: ProteinReference
xref: uniprot Q60934 89
xref: PTHR18966:SF36
organism: Mus musculus

Glu4 s19 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glu4
stoichiometric coefficient: 1.0

Voltage-dependent calcium channel gamma-2 subunit
type: ProteinReference
xref: uniprot A0A1D5R2B1 7
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Complex__Glu4_Glu2__Glu1_-RIGHT__AMPA-_r127
controller: Complex (PICK/CaMKII)

uniprot A0A3Q1M9Y0 62
type: UnificationXref
id: A0A3Q1M9Y0
db: uniprot

PARTICIPANT STOICHIOMETRY re39 549
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re39 548
type: Stoichiometry
physical entity: Complex (NMDA/PSD95)
stoichiometric coefficient: 1.0

Glutamate receptor IB, isoform B
type: ProteinReference
xref: PTHR18966:SF505
xref: uniprot M9PHV5 326
organism: Drosophila melanogaster

vesicle
type: CellularLocationVocabulary
xref: GO GO:0031982 4

uniprot F7G485 76
type: UnificationXref
id: F7G485
db: uniprot

uniprot Q22682 180
type: UnificationXref
id: Q22682
db: uniprot

GRM3 protein
type: ProteinReference
xref: uniprot A5D7D8 273
xref: PTHR24060:SF160
organism: Bos taurus

NR2A
type: Protein
entity reference: NR2A
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r111 537
type: Stoichiometry
physical entity: Complex (SNARE Complex/Ca2+)
stoichiometric coefficient: 1.0

Vesicular glutamate transporter 3
type: ProteinReference
xref: uniprot Q8NDX2 371
xref: PTHR11662:SF207
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r111 536
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r111 535
type: Stoichiometry
physical entity: SNARE Complex
stoichiometric coefficient: 1.0

uniprot A8X8S6 200
type: UnificationXref
id: A8X8S6
db: uniprot

KA2
type: Protein
entity reference: KA2
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

Glutamate receptor, ionotropic, AMPA 3a
type: ProteinReference
xref: PTHR18966:SF527
xref: uniprot A2CG69 297
organism: Danio rerio

Voltage-dependent calcium channel gamma-5 subunit
type: ProteinReference
xref: PTHR12107:SF4
xref: uniprot X1WEB1 26
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F7AGW3 84
xref: PTHR18966:SF36
organism: Macaca mulatta

ncbitaxon 44689 351
type: UnificationXref
id: 44689
db: ncbitaxon

Excitatory amino acid transporter
type: ProteinReference
xref: uniprot Q10901 179
xref: PTHR11958:SF89
organism: Caenorhabditis elegans

uniprot B1AS29 63
type: UnificationXref
id: B1AS29
db: uniprot

uniprot Q95135 185
type: UnificationXref
id: Q95135
db: uniprot

uniprot O18210 164
type: UnificationXref
id: O18210
db: uniprot

uniprot A0A2I3T979 81
type: UnificationXref
id: A0A2I3T979
db: uniprot

uniprot F6R0Q4 204
type: UnificationXref
id: F6R0Q4
db: uniprot

uniprot A0A2I3TTD0 144
type: UnificationXref
id: A0A2I3TTD0
db: uniprot

PTHR19305:SF5
type: RelationshipXref
id: PTHR19305:SF5
db: PANTHER Family
relationship type: By Homology

Complex (PICK/CaMKII)
type: Complex
component stoichiometry: CaMKII s5 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: PICK s3 sa3 STOICHIOMETRY ID COMPLEX
component: PICK
component: CaMKII
feature: COMPLEX BINDING FEATURE s139 a139 422
feature: COMPLEX BINDING FEATURE s139 a139 424
cellular location: cytosol

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 260

PTHR19305:SF9
type: RelationshipXref
id: PTHR19305:SF9
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR11662:SF201
xref: uniprot F6UMW2 364
organism: Macaca mulatta

uniprot A0A0R4IFU7 140
type: UnificationXref
id: A0A0R4IFU7
db: uniprot

Calcium/calmodulin-dependent protein kinase type II subunit alpha
type: ProteinReference
xref: uniprot P11798 389
xref: PTHR24347:SF384
organism: Mus musculus

uniprot Q61983 367
type: UnificationXref
id: Q61983
db: uniprot

uniprot Q5TXC3 181
type: UnificationXref
id: Q5TXC3
db: uniprot

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 91
xref: uniprot Q05586 133
xref: PTHR18966:SF377
organism: Homo sapiens

Glutamate receptor 1
type: ProteinReference
xref: PTHR18966:SF505
xref: uniprot Q03445 330
organism: Drosophila melanogaster

uniprot P08413 387
type: UnificationXref
id: P08413
db: uniprot

uniprot H2R892 280
type: UnificationXref
id: H2R892
db: uniprot

uniprot Q13554 392
type: UnificationXref
id: Q13554
db: uniprot

ncbitaxon 100226 187
type: UnificationXref
id: 100226
db: ncbitaxon

PTHR19305:SF4
type: RelationshipXref
id: PTHR19305:SF4
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

AMPA
type: ProteinReference
xref: P01019
standard name: glutamate receptor, ionotropic, AMPA
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.ION_CHANNEL.AMPA
comment: ENTITY_REFERENCE_NOTES=Long Name: AMPA Receptor Synonym: AMPA Receptor Accession: P01019
member entity reference: Glutamate receptor 2
member entity reference: GRIA3 isoform 2
member entity reference: Glutamate receptor 1
member entity reference: Glutamate ionotropic receptor AMPA type subunit 4
member entity reference: Uncharacterized protein
member entity reference: Glutamate receptor, ionotropic, AMPA 2a
member entity reference: Glutamate receptor, ionotropic, AMPA 4a
member entity reference: Glutamate receptor, ionotropic, AMPA 3
member entity reference: Glutamate receptor 3
member entity reference: Glutamate ionotropic receptor AMPA type subunit 2
member entity reference: Glutamate receptor, ionotropic, AMPA 3b
member entity reference: GLutamate Receptor family (AMPA)
member entity reference: Glutamate receptor IB, isoform B
member entity reference: Ionotropic glutamate receptor AMPA 1
member entity reference: Protein CBR-GLR-1
member entity reference: AGAP006027-PA
member entity reference: Glutamate ionotropic receptor AMPA type subunit 3
member entity reference: GRIA2 isoform 6
member entity reference: Glutamate receptor 4
member entity reference: Glutamate receptor, ionotropic, AMPA 3a
member entity reference: Glutamate receptor, ionotropic, AMPA 2b
member entity reference: Glutamate receptor, ionotropic, AMPA 4b
member entity reference: GRIA1 isoform 11

uniprot F1PWT6 66
type: UnificationXref
id: F1PWT6
db: uniprot

Glutamate receptor ionotropic, NMDA 3B
type: ProteinReference
evidence: Evidence 91
evidence: Evidence 117
xref: uniprot Q91ZU9 124
xref: PTHR18966:SF364
organism: Mus musculus

Glutamate ionotropic receptor kainate type subunit 5
type: ProteinReference
xref: uniprot A0A2I3S1J9 44
xref: PTHR18966:SF351
organism: Pan troglodytes

PTHR18966:SF99
type: RelationshipXref
id: PTHR18966:SF99
db: PANTHER Family
relationship type: By Homology

uniprot X1WEB1 26
type: UnificationXref
id: X1WEB1
db: uniprot

Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
type: ProteinReference
xref: PTHR24347:SF398
xref: uniprot K9J7V0 385
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r134 492
type: Stoichiometry
physical entity: Complex (Glu4/Glu3/ Glu2)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r134 491
type: Stoichiometry
physical entity: Glu4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r134 490
type: Stoichiometry
physical entity: Glu3
stoichiometric coefficient: 1.0

NR1
type: ProteinReference
xref: P01010
standard name: Glutamate/NMDA receptor zeta 1 subunit / z 1 subunit
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.NR1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Glutamate/NMDA receptor zeta 1 subunit / z 1 subunit Synonym: GLURZ1,GRIN1,NR1 Accession: P01010
member entity reference: Glutamate receptor ionotropic, NMDA 1
member entity reference: Glutamate [NMDA] receptor subunit 1
member entity reference: Protein CBR-NMR-1
member entity reference: NMDA class glutamate Receptor
member entity reference: Glutamate ionotropic receptor NMDA type subunit 1
member entity reference: N-methyl-D-aspartate receptor type 1 subunit
member entity reference: Glutamate receptor, ionotropic, N-methyl D-aspartate 1b
member entity reference: Glutamate [NMDA] receptor subunit zeta-1 isoform NR1-3
member entity reference: AGAP001478-PA
member entity reference: Glutamate receptor, ionotropic, N-methyl D-aspartate 1a

uniprot F7FY70 312
type: UnificationXref
id: F7FY70
db: uniprot

Probable glutamate receptor
type: ProteinReference
xref: PTHR18966:SF417
xref: uniprot A0A452J7P8 403
organism: Gallus gallus

Glutamate receptor, ionotropic, kainate 5
type: ProteinReference
xref: uniprot Q2HJD2 49
xref: PTHR18966:SF351
organism: Bos taurus

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF63
xref: uniprot Q7QI86 183
organism: Anopheles gambiae

Evidence 319
type: Evidence
evidence code: ISS
comment: Website http://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891

PTHR23078:SF3
type: RelationshipXref
id: PTHR23078:SF3
db: PANTHER Family
relationship type: By Homology

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 24

uniprot H2QUV3 279
type: UnificationXref
id: H2QUV3
db: uniprot

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF24
xref: uniprot Q9N280 188
organism: Canis lupus familiaris

Ca2+ channel
type: Protein
feature: ACTIVE 374
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

KA3
type: Protein
entity reference: KA3
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

Glu3
type: ProteinReference
xref: P01016
standard name: Glutamate receptor, ionotropic, AMPA 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.Glu3
comment: ENTITY_REFERENCE_NOTES=Long Name: Glutamate receptor, ionotropic, AMPA 3 Synonym: AMPA,AMPA R,GRIA2,glu3,glur3 Accession: P01016
member entity reference: Glutamate ionotropic receptor AMPA type subunit 3
member entity reference: Glutamate receptor 3
member entity reference: GRIA3 isoform 2
member entity reference: Glutamate receptor, ionotropic, AMPA 3a
member entity reference: Glutamate receptor, ionotropic, AMPA 3
member entity reference: Uncharacterized protein
member entity reference: Glutamate receptor, ionotropic, AMPA 3b

Vesicular-fusion protein SEC18
type: ProteinReference
xref: uniprot P18759 342
xref: PTHR23078:SF3
organism: Saccharomyces cerevisiae

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot Q28HP6 245
xref: PTHR19305:SF5
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r117 520
type: Stoichiometry
physical entity: Complex (KA/Glutamate)
stoichiometric coefficient: 1.0

uniprot Q9Y566 43
type: UnificationXref
id: Q9Y566
db: uniprot

Glu2 s21 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glu2
stoichiometric coefficient: 1.0

Amino acid transporter
type: ProteinReference
xref: uniprot A0A2I3T0G3 143
xref: PTHR11958:SF24
organism: Pan troglodytes

uniprot A0A2I3T0G3 143
type: UnificationXref
id: A0A2I3T0G3
db: uniprot

PARTICIPANT STOICHIOMETRY r117 519
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Evidence 306
type: Evidence
evidence code: ISS
comment: Website Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 222

Amino acid transporter
type: ProteinReference
xref: uniprot A0A3Q1MR13 145
xref: PTHR11958:SF93
organism: Bos taurus

uniprot E2QUL2 201
type: UnificationXref
id: E2QUL2
db: uniprot

uniprot F7HEB8 313
type: UnificationXref
id: F7HEB8
db: uniprot

uniprot Q9WV48 42
type: UnificationXref
id: Q9WV48
db: uniprot

Solute carrier family 17 member 6
type: ProteinReference
xref: uniprot F6T3N3 362
xref: PTHR11662:SF201
organism: Ornithorhynchus anatinus

Glutamate [NMDA] receptor subunit zeta-1 isoform NR1-3
type: ProteinReference
evidence: Evidence 91
xref: PTHR18966:SF377
xref: uniprot F7GR67 128
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r117 518
type: Stoichiometry
physical entity: KA
stoichiometric coefficient: 1.0

Calcium/calmodulin-dependent protein kinase type II subunit gamma
type: ProteinReference
xref: uniprot Q923T9 400
xref: PTHR24347:SF398
organism: Mus musculus

uniprot Q7QEK3 399
type: UnificationXref
id: Q7QEK3
db: uniprot

uniprot Q9Y698 25
type: UnificationXref
id: Q9Y698
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF100
xref: uniprot F7AGS3 291
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NGS8 380
xref: PTHR24347:SF384
organism: Gallus gallus

HETERODIMER_ASSOCIATION_LEFT__NR1-_NR2B-RIGHT__NMDA-_r94
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 499
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 501
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 500
left: NR1
left: NR2B
interaction type: HETERODIMER_ASSOCIATION
right: NMDA

Glu3
type: Protein
entity reference: Glu3
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa19 415
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r97 485
type: Stoichiometry
physical entity: NMDA
stoichiometric coefficient: 1.0

Glu4
type: Protein
entity reference: Glu4
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa15 445
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r97 486
type: Stoichiometry
physical entity: NMDA
stoichiometric coefficient: 1.0

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot P31109 228
organism: Saccharomyces cerevisiae

PICK
type: ProteinReference
xref: P01012
standard name: protein that interacts with C kinase 1
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.PICK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: PRKCA-binding protein
member entity reference: Protein interacting with PRKCA 1
member entity reference: Uncharacterized protein

GRIA1 isoform 11
type: ProteinReference
xref: uniprot A0A2I3TR48 322
xref: PTHR18966:SF157
organism: Pan troglodytes

CaMKII
type: Protein
entity reference: CaMKII
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa4 425
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1MCL3 105
type: UnificationXref
id: F1MCL3
db: uniprot

uniprot P60879 233
type: UnificationXref
id: P60879
db: uniprot

PARTICIPANT STOICHIOMETRY r130 510
type: Stoichiometry
physical entity: AMPA
stoichiometric coefficient: 1.0

uniprot H2RCB8 217
type: UnificationXref
id: H2RCB8
db: uniprot

uniprot P35438 131
type: UnificationXref
id: P35438
db: uniprot

PARTICIPANT STOICHIOMETRY r128 543
type: Stoichiometry
physical entity: A/K
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__KA-RIGHT__A_K-_r75
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 528
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 527
left: KA
interaction type: TRANSPORT
right: A/K

Vesicular glutamate transporter 2
type: ProteinReference
xref: uniprot Q9JI12 372
xref: PTHR11662:SF201
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r128 542
type: Stoichiometry
physical entity: Complex (Glu4/Glu3/ Glu2)
stoichiometric coefficient: 1.0

uniprot P23818 327
type: UnificationXref
id: P23818
db: uniprot

PTHR12141:SF1
type: RelationshipXref
id: PTHR12141:SF1
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
evidence: Evidence 106
evidence: Evidence 91
xref: uniprot F6PGX6 108
xref: PTHR18966:SF382
organism: Monodelphis domestica

uniprot O62305 386
type: UnificationXref
id: O62305
db: uniprot

uniprot Q13557 393
type: UnificationXref
id: Q13557
db: uniprot

Na+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

uniprot Q7TSF2 368
type: UnificationXref
id: Q7TSF2
db: uniprot

uniprot F1NMB0 107
type: UnificationXref
id: F1NMB0
db: uniprot

SNAP29 isoform 1
type: ProteinReference
xref: uniprot H2QLA1 214
xref: PTHR19305:SF9
organism: Pan troglodytes

PTHR24347:SF365
type: RelationshipXref
id: PTHR24347:SF365
db: PANTHER Family
relationship type: By Homology

uniprot B7WN72 33
type: UnificationXref
id: B7WN72
db: uniprot

PTHR24135:SF18
type: RelationshipXref
id: PTHR24135:SF18
db: PANTHER Family
relationship type: By Homology

PTHR24135:SF17
type: RelationshipXref
id: PTHR24135:SF17
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9031 16
type: UnificationXref
id: 9031
db: ncbitaxon

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 351

Glu2 s17 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glu2
stoichiometric coefficient: 1.0

SLC17A6 isoform 1
type: ProteinReference
xref: uniprot H2R3D0 366
xref: PTHR11662:SF201
organism: Pan troglodytes

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot A0A286YAY2 402
type: UnificationXref
id: A0A286YAY2
db: uniprot

uniprot H2R6U6 162
type: UnificationXref
id: H2R6U6
db: uniprot

Glutamate ionotropic receptor NMDA type subunit 1
type: ProteinReference
evidence: Evidence 91
xref: uniprot F7CS79 127
xref: PTHR18966:SF377
organism: Xenopus tropicalis

Vglut
type: ProteinReference
xref: P01021
standard name: Vesicular Glutamate Transporter
comment: ENTITY_REFERENCE_NOTES=Long Name: Vesicular Glutamate Transporter Synonym: Synonym not specified Accession: P01021
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.Vglut
member entity reference: Vesicular glutamate transporter 2
member entity reference: Uncharacterized protein
member entity reference: Solute carrier family 17 member 6
member entity reference: Sodium-dependent phosphate transport protein 1
member entity reference: Solute carrier family 17 member 8
member entity reference: Vesicular glutamate transporter 3
member entity reference: SLC17A6 isoform 1

NSF
type: ProteinReference
xref: P01020
standard name: N-Ethylmaleimide-sensitive fusion protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.NSF
comment: ENTITY_REFERENCE_NOTES=Long Name: N-Ethylmaleimide-sensitive fusion protein Synonym: Synonym not specified Accession: P01020
member entity reference: Vesicle-fusing ATPase
member entity reference: N-ethylmaleimide sensitive factor, vesicle fusing ATPase
member entity reference: Uncharacterized protein
member entity reference: RE10813p
member entity reference: N-ethylmaleimide-sensitive fusion protein
member entity reference: Vesicle-fusing ATPase 1
member entity reference: Vesicular-fusion protein NsF, putative N-ethylmaleimide sensitive factor (NsF)
member entity reference: Vesicular-fusion protein sec18
member entity reference: Vesicular-fusion protein SEC18

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF157
xref: uniprot F7B4C1 324
organism: Monodelphis domestica

stargazin
type: ProteinReference
xref: P00998
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.stargazin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: stargazin Synonym: TARP Accession: P00998
member entity reference: Voltage-dependent calcium channel gamma-5 subunit
member entity reference: Voltage-dependent calcium channel gamma-2 subunit

Glutamate metabotropic receptor 2
type: ProteinReference
xref: uniprot E1BAB4 274
xref: PTHR24060:SF147
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
evidence: Evidence 306
xref: PTHR18966:SF99
xref: uniprot F7HEB8 313
organism: Macaca mulatta

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 349

NR2A
type: ProteinReference
xref: P01008
standard name: Glutamate/NMDA receptor epsilon 1 subunit / e 1 subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.NR2A
comment: ENTITY_REFERENCE_NOTES=Long Name: Glutamate/NMDA receptor epsilon 1 subunit / e 1 subunit Synonym: GRIN2A,N-methyl D-aspartate receptor subtype 2A,NMDAR2A Accession: P01008
member entity reference: Glutamate receptor ionotropic, NMDA 2A
member entity reference: Glutamate ionotropic receptor NMDA type subunit 2A
member entity reference: Uncharacterized protein

Ca2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

Voltage-dependent calcium channel gamma-5 subunit
type: ProteinReference
xref: PTHR12107:SF4
xref: uniprot Q8VHW4 22
organism: Mus musculus

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 57

EAAT s227 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EAAT
stoichiometric coefficient: 1.0

uniprot Q9JI12 372
type: UnificationXref
id: Q9JI12
db: uniprot

uniprot Q9ERB0 263
type: UnificationXref
id: Q9ERB0
db: uniprot

TRANSPORT_LEFT__Glutamate-RIGHT__Glutamate-_r66
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 484
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 483
left: Glutamate
interaction type: TRANSPORT
right: Glutamate

uniprot F7F4B9 338
type: UnificationXref
id: F7F4B9
db: uniprot

uniprot Q0V7N0 242
type: UnificationXref
id: Q0V7N0
db: uniprot

ncbitaxon 227321 249
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot Q01812 56
type: UnificationXref
id: Q01812
db: uniprot

uniprot Q14416 283
type: UnificationXref
id: Q14416
db: uniprot

PARTICIPANT STOICHIOMETRY r134 489
type: Stoichiometry
physical entity: Glu2
stoichiometric coefficient: 1.0

AGAP006027-PA
type: ProteinReference
xref: uniprot Q7PNT0 333
xref: PTHR18966:SF505
organism: Anopheles gambiae

Vglut s8 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Vglut
stoichiometric coefficient: 1.0

uniprot F6YMH2 208
type: UnificationXref
id: F6YMH2
db: uniprot

uniprot F6ZDV3 158
type: UnificationXref
id: F6ZDV3
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Na_PLUS_-RIGHT__Na_PLUS_-_r119
control type: ACTIVATION
controller: s221

uniprot Q9VDH5 411
type: UnificationXref
id: Q9VDH5
db: uniprot

Vesicular-fusion protein SEC18
type: ProteinReference
xref: uniprot Q1K5G2 346
xref: PTHR23078:SF3
organism: Neurospora crassa

LD13733p
type: ProteinReference
xref: PTHR24135:SF18
xref: uniprot A1Z9K8 29
organism: Drosophila melanogaster

Vesicle-fusing ATPase
type: ProteinReference
xref: uniprot Q9QUL6 355
xref: PTHR23078:SF3
organism: Rattus norvegicus

uniprot Q8TCU5 122
type: UnificationXref
id: Q8TCU5
db: uniprot

uniprot Q7PNT0 333
type: UnificationXref
id: Q7PNT0
db: uniprot

uniprot A8WZ27 146
type: UnificationXref
id: A8WZ27
db: uniprot

PARTICIPANT STOICHIOMETRY r123 466
type: Stoichiometry
physical entity: KA2
stoichiometric coefficient: 1.0

Glu4 s16 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glu4
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Vglut-_Glutamate-RIGHT__Complex__Vglut_Glutamate_-_r112
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r112 533
participant stoichiometry: PARTICIPANT STOICHIOMETRY r112 532
participant stoichiometry: PARTICIPANT STOICHIOMETRY r112 534
left: Vglut
left: Glutamate
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Vglut/Glutamate)

PARTICIPANT STOICHIOMETRY r123 467
type: Stoichiometry
physical entity: KA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r123 464
type: Stoichiometry
physical entity: KA3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r123 465
type: Stoichiometry
physical entity: KA1
stoichiometric coefficient: 1.0

uniprot Q9LMG8 264
type: UnificationXref
id: Q9LMG8
db: uniprot

uniprot A0A1D5R2U8 52
type: UnificationXref
id: A0A1D5R2U8
db: uniprot

uniprot Q00959 100
type: UnificationXref
id: Q00959
db: uniprot

Vesicular glutamate transporter 3
type: ProteinReference
xref: PTHR11662:SF207
xref: uniprot Q7TSF2 368
organism: Rattus norvegicus

uniprot Q6PC54 255
type: UnificationXref
id: Q6PC54
db: uniprot

uniprot A0A2I3TUE7 378
type: UnificationXref
id: A0A2I3TUE7
db: uniprot

Voltage-dependent calcium channel gamma-5 subunit
type: ProteinReference
xref: PTHR12107:SF4
xref: uniprot E1C4A6 15
organism: Gallus gallus

uniprot M9PHV5 326
type: UnificationXref
id: M9PHV5
db: uniprot

uniprot Q5R1P0 135
type: UnificationXref
id: Q5R1P0
db: uniprot

Ca2 PLUS s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot Q9UQM7 401
type: UnificationXref
id: Q9UQM7
db: uniprot

uniprot Q66IG3 254
type: UnificationXref
id: Q66IG3
db: uniprot

t-SNARE protein aex-4
type: ProteinReference
xref: uniprot G5EEN8 212
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r123 463
type: Stoichiometry
physical entity: KA5
stoichiometric coefficient: 1.0

SH3 and multiple ankyrin repeat domains protein 3
type: ProteinReference
xref: uniprot Q9BYB0 39
xref: PTHR24135:SF4
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r130 509
type: Stoichiometry
physical entity: Complex (Glu4/Glu3/ Glu2)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r123 462
type: Stoichiometry
physical entity: KA4
stoichiometric coefficient: 1.0

Glu3
type: Protein
entity reference: Glu3
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot Q9L0U6 186
type: UnificationXref
id: Q9L0U6
db: uniprot

uniprot A0A3Q1MKC7 379
type: UnificationXref
id: A0A3Q1MKC7
db: uniprot

Calcium/calmodulin-dependent protein kinase type II subunit delta
type: ProteinReference
xref: PTHR24347:SF365
xref: uniprot Q6PHZ2 398
organism: Mus musculus

uniprot A0A1D5QYR9 197
type: UnificationXref
id: A0A1D5QYR9
db: uniprot

ncbitaxon 9606 24
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot P31596 169
type: UnificationXref
id: P31596
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot P23763 227
xref: PTHR45701:SF1
organism: Homo sapiens

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re41
control type: ACTIVATION
controller: Complex (mGluR 2/3/ Glutamate)

PTHR12107:SF4
type: RelationshipXref
id: PTHR12107:SF4
db: PANTHER Family
relationship type: By Homology

Sodium-dependent phosphate transport protein 1
type: ProteinReference
xref: uniprot Q61983 367
organism: Mus musculus

uniprot Q63273 51
type: UnificationXref
id: Q63273
db: uniprot

Excitatory amino acid transporter 1
type: ProteinReference
xref: uniprot P56564 178
xref: PTHR11958:SF24
organism: Mus musculus

PTHR24060:SF160
type: RelationshipXref
id: PTHR24060:SF160
db: PANTHER Family
relationship type: By Homology

Vesicular-fusion protein sec18
type: ProteinReference
xref: uniprot Q9P7Q4 354
xref: PTHR23078:SF3
organism: Schizosaccharomyces pombe

uniprot E1BQU4 336
type: UnificationXref
id: E1BQU4
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

Vesicular glutamate transporter 2
type: ProteinReference
xref: uniprot A6QLI1 357
xref: PTHR11662:SF201
organism: Bos taurus

uniprot F7FB74 54
type: UnificationXref
id: F7FB74
db: uniprot

TRANSPORT
type: InteractionVocabulary

s218
type: Complex
component stoichiometry: PSD95 s219 a182 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glutamate s220 a109 STOICHIOMETRY ID COMPLEX
component stoichiometry: NMDA s107 a103 STOICHIOMETRY ID COMPLEX
component: PSD95
component: NMDA
component: Glutamate
feature: COMPLEX BINDING FEATURE s218 csa10 434
feature: COMPLEX BINDING FEATURE s218 csa10 432
feature: COMPLEX BINDING FEATURE s218 csa10 430
cellular location: cytosol

uniprot Q6ZM67 137
type: UnificationXref
id: Q6ZM67
db: uniprot

Glutamate s13 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

uniprot F6UIA5 363
type: UnificationXref
id: F6UIA5
db: uniprot

uniprot Q14957 104
type: UnificationXref
id: Q14957
db: uniprot

uniprot H2QLK9 17
type: UnificationXref
id: H2QLK9
db: uniprot

uniprot O02495 220
type: UnificationXref
id: O02495
db: uniprot

PTHR24060:SF147
type: RelationshipXref
id: PTHR24060:SF147
db: PANTHER Family
relationship type: By Homology

uniprot Q9UF02 23
type: UnificationXref
id: Q9UF02
db: uniprot

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 91
xref: uniprot Q5R1P0 135
xref: PTHR18966:SF377
organism: Canis lupus familiaris

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 106
evidence: Evidence 91
xref: uniprot Q5R1P3 114
xref: PTHR18966:SF382
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY re39 550
type: Stoichiometry
physical entity: s218
stoichiometric coefficient: 1.0

ncbitaxon 284812 260
type: UnificationXref
id: 284812
db: ncbitaxon

SNARE Complex
type: ProteinReference
xref: P01013
standard name: N-ethylmaleimide-sensitive factor attachment protein receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: N-ethylmaleimide-sensitive factor attachment protein receptor Synonym: SNARE Accession: P01013
comment: ENTITY_REFERENCE_ID_DESC=Ionotropic glutamate receptor pathway.PROTEIN.GENERIC.SNARE Complex
member entity reference: Synaptosomal-associated protein 25-B
member entity reference: t-SNARE protein aex-4
member entity reference: Syntaxin-11
member entity reference: Synaptosomal-associated protein 29
member entity reference: Synaptosomal-associated protein
member entity reference: Uncharacterized protein
member entity reference: Vesicle-associated membrane protein 3
member entity reference: Vesicle-associated membrane protein 1
member entity reference: LD03592p
member entity reference: Synaptobrevin-1
member entity reference: VAMP3 isoform 1
member entity reference: SNAP25 homologous protein SNAP29
member entity reference: Vesicle associated membrane protein 8
member entity reference: Syntaxin 11a
member entity reference: Vesicle-associated membrane protein 8
member entity reference: Vesicle-associated membrane protein 2
member entity reference: Synaptosomal-associated protein 25
member entity reference: Vesicle associated membrane protein 1
member entity reference: Syntaxin 19
member entity reference: Vesicle-associated membrane protein 8 (Endobrevin)
member entity reference: MGC89708 protein
member entity reference: Putative SNAP25 homologous protein SNAP30
member entity reference: Syntaxin-19
member entity reference: Synaptobrevin
member entity reference: STX11 isoform 1
member entity reference: Soluble NSF attachment protein 29
member entity reference: Neuronal synaptobrevin, isoform J
member entity reference: Synaptobrevin homolog 1
member entity reference: SNAP25 homologous protein SNAP33
member entity reference: VAMP2 isoform 3
member entity reference: Putative synaptobrevin homologue SNC1/2 (Eurofung)
member entity reference: Synaptosomal-associated protein 25-A
member entity reference: SNAP29 isoform 1
member entity reference: Synaptosomal-associated protein 23

uniprot A0A3Q1MR13 145
type: UnificationXref
id: A0A3Q1MR13
db: uniprot

uniprot Q4ACU6 37
type: UnificationXref
id: Q4ACU6
db: uniprot

Glutamate ionotropic receptor AMPA type subunit 3
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot E2RHU1 298
organism: Canis lupus familiaris

NMDA class glutamate Receptor
type: ProteinReference
evidence: Evidence 91
xref: uniprot G5EGQ9 130
xref: PTHR18966:SF377
organism: Caenorhabditis elegans

HETERODIMER_ASSOCIATION_LEFT__KA-_Glutamate-RIGHT__Complex__KA_Glutamate_-_r117
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r117 520
participant stoichiometry: PARTICIPANT STOICHIOMETRY r117 519
participant stoichiometry: PARTICIPANT STOICHIOMETRY r117 518
left: Glutamate
left: KA
interaction type: HETERODIMER_ASSOCIATION
right: Complex (KA/Glutamate)

uniprot F6UBJ8 205
type: UnificationXref
id: F6UBJ8
db: uniprot

PTHR24347:SF384
type: RelationshipXref
id: PTHR24347:SF384
db: PANTHER Family
relationship type: By Homology

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 5

SH3 and multiple ankyrin repeat domains protein 2
type: ProteinReference
xref: PTHR24135:SF17
xref: uniprot Q80Z38 38
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r66 484
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

SH3 and multiple ankyrin repeat domains protein 1
type: ProteinReference
xref: uniprot Q9Y566 43
xref: PTHR24135:SF3
organism: Homo sapiens

SH3 and multiple ankyrin repeat domains protein 2
type: ProteinReference
xref: PTHR24135:SF17
xref: uniprot Q9QX74 41
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r66 483
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r127 547
type: Stoichiometry
physical entity: AMPA
stoichiometric coefficient: 1.0

uniprot Q8ING5 352
type: UnificationXref
id: Q8ING5
db: uniprot

PARTICIPANT STOICHIOMETRY r127 546
type: Stoichiometry
physical entity: Complex (Glu4/Glu2/ Glu1)
stoichiometric coefficient: 1.0

uniprot Q13224 113
type: UnificationXref
id: Q13224
db: uniprot

KA5
type: Protein
entity reference: KA5
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot O95721 225
type: UnificationXref
id: O95721
db: uniprot

uniprot Q03391 94
type: UnificationXref
id: Q03391
db: uniprot

TRANSPORT_LEFT__Complex__Glu4_Glu3__Glu2_-RIGHT__A_K-_r128
type: ComplexAssembly
spontaneous: false
conversion direction: REVERSIBLE
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r128 542
participant stoichiometry: PARTICIPANT STOICHIOMETRY r128 543
left: Complex (Glu4/Glu3/ Glu2)
interaction type: TRANSPORT
right: A/K

uniprot F1PRG8 202
type: UnificationXref
id: F1PRG8
db: uniprot

uniprot F7AGW3 84
type: UnificationXref
id: F7AGW3
db: uniprot

PARTICIPANT STOICHIOMETRY re40 515
type: Stoichiometry
physical entity: s221
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re40 513
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PTHR24347:SF398
type: RelationshipXref
id: PTHR24347:SF398
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re40 514
type: Stoichiometry
physical entity: A/K
stoichiometric coefficient: 1.0

Glutamate ionotropic receptor kainate type subunit 3
type: ProteinReference
xref: PTHR18966:SF174
xref: uniprot F7ANC6 68
organism: Ornithorhynchus anatinus

uniprot F6YN64 290
type: UnificationXref
id: F6YN64
db: uniprot

uniprot E2RDG5 359
type: UnificationXref
id: E2RDG5
db: uniprot

uniprot Q9Z2P6 272
type: UnificationXref
id: Q9Z2P6
db: uniprot

AGAP001478-PA
type: ProteinReference
evidence: Evidence 91
xref: PTHR18966:SF377
xref: uniprot Q7PXM3 138
organism: Anopheles gambiae

NMDA s107 a103 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NMDA
stoichiometric coefficient: 1.0