PARTICIPANT STOICHIOMETRY r2 145
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 147
type: Stoichiometry
physical entity: CO2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 146
type: Stoichiometry
physical entity: 2-oxobutanoate
stoichiometric coefficient: 1.0

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot F1PY28 10
organism: Canis lupus familiaris

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 55

ncbitaxon 64091 55
type: UnificationXref
id: 64091
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r2 148
type: Stoichiometry
physical entity: 2-aceto-2-hydroxy butyrate
stoichiometric coefficient: 1.0

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot A0A2I3RE03 4
organism: Pan troglodytes

Branched chain amino acid aminotransferase
type: ProteinReference
xref: P02994
comment: ENTITY_REFERENCE_ID_DESC=Isoleucine biosynthesis.PROTEIN.GENERIC.Branched chain_br_amino acid aminotransferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Branched chain amino acid aminotransferase Synonym: Synonym not specified Accession: P02994
member entity reference: Branched-chain-amino-acid aminotransferase, cytosolic
member entity reference: Branched-chain-amino-acid aminotransferase 6
member entity reference: Branched-chain-amino-acid aminotransferase
member entity reference: Branched-chain-amino-acid aminotransferase, mitochondrial
member entity reference: Branched-chain-amino-acid aminotransferase 3, chloroplastic
member entity reference: Branched-chain-amino-acid transaminase 1
member entity reference: Probable branched-chain-amino-acid aminotransferase
member entity reference: Methionine aminotransferase BCAT4
member entity reference: Putative branched-chain-amino-acid aminotransferase
member entity reference: Putative branched-chain-amino-acid aminotransferase 7
member entity reference: Branched-chain-amino-acid aminotransferase 2

Dihydroxy-acid dehydratase, mitochondrial
type: ProteinReference
xref: uniprot P39522 123
organism: Saccharomyces cerevisiae

uniprot Q5EA40 45
type: UnificationXref
id: Q5EA40
db: uniprot

uniprot Q8A608 131
type: UnificationXref
id: Q8A608
db: uniprot

uniprot Q9RU74 81
type: UnificationXref
id: Q9RU74
db: uniprot

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 74

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot A0A3Q1ML78 6
organism: Bos taurus

isoleucine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9WZ18 118
type: UnificationXref
id: Q9WZ18
db: uniprot

ncbitaxon 6238 9
type: UnificationXref
id: 6238
db: ncbitaxon

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 49

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 106

Methionine aminotransferase BCAT4
type: ProteinReference
xref: uniprot Q9LE06 56
organism: Arabidopsis thaliana

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q7SBQ5 129
organism: Neurospora crassa

uniprot P54688 34
type: UnificationXref
id: P54688
db: uniprot

uniprot Q7QEI9 48
type: UnificationXref
id: Q7QEI9
db: uniprot

uniprot P54687 33
type: UnificationXref
id: P54687
db: uniprot

uniprot A1L0T0 85
type: UnificationXref
id: A1L0T0
db: uniprot

STATE_TRANSITION_LEFT__glutamate-_2_keto_3_methyl_valerate-RIGHT__2_oxoglutarate-_isoleucine-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 156
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 155
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 154
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 153
left: 2-keto-3-methyl-valerate
left: glutamate
interaction type: STATE_TRANSITION
right: isoleucine
right: 2-oxoglutarate

uniprot Q57725 103
type: UnificationXref
id: Q57725
db: uniprot

Dihydroxy-acid dehydratase, chloroplastic
type: ProteinReference
xref: uniprot Q9LIR4 136
organism: Arabidopsis thaliana

threonine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9WZ21 139
type: UnificationXref
id: Q9WZ21
db: uniprot

uniprot Q6K2E8 107
type: UnificationXref
id: Q6K2E8
db: uniprot

uniprot P38891 29
type: UnificationXref
id: P38891
db: uniprot

uniprot Q9X9Y4 140
type: UnificationXref
id: Q9X9Y4
db: uniprot

Acetolactate synthase
type: ProteinReference
xref: uniprot Q8TPF5 110
organism: Methanosarcina acetivorans

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 83

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q9XXD8 65
organism: Caenorhabditis elegans

Mus musculus
type: BioSource
xref: ncbitaxon 10090 21

Branched-chain-amino-acid transaminase 1
type: ProteinReference
xref: uniprot O31461 16
organism: Bacillus subtilis

uniprot O31461 16
type: UnificationXref
id: O31461
db: uniprot

Putative branched-chain-amino-acid aminotransferase 7
type: ProteinReference
xref: uniprot Q9LPM8 58
organism: Arabidopsis thaliana

Branched-chain-amino-acid aminotransferase 6
type: ProteinReference
xref: uniprot Q9LPM9 59
organism: Arabidopsis thaliana

Acetolactate synthase
type: Protein
entity reference: Acetolactate synthase
comment: SPECIES_TYPE=PROTEIN

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q7QEI9 48
organism: Anopheles gambiae

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 30

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 38

Branched-chain-amino-acid aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot O35855 20
organism: Mus musculus

Putative dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q9X9Y4 140
organism: Streptomyces coelicolor

uniprot P9WG41 101
type: UnificationXref
id: P9WG41
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 64

Acetolactate synthase-like protein
type: ProteinReference
xref: uniprot A6QQT9 86
organism: Bos taurus

Ketol-acid reductoisomerase, mitochondrial
type: ProteinReference
xref: uniprot P06168 67
organism: Saccharomyces cerevisiae

Probable branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot O67733 22
organism: Aquifex aeolicus

Acetolactate synthase
type: ProteinReference
xref: uniprot O66759 93
organism: Aquifex aeolicus

ncbitaxon 243090 76
type: UnificationXref
id: 243090
db: ncbitaxon

uniprot Q9I280 115
type: UnificationXref
id: Q9I280
db: uniprot

uniprot Q7NH80 73
type: UnificationXref
id: Q7NH80
db: uniprot

uniprot Q6AT43 46
type: UnificationXref
id: Q6AT43
db: uniprot

uniprot Q9XXD8 65
type: UnificationXref
id: Q9XXD8
db: uniprot

uniprot O67009 120
type: UnificationXref
id: O67009
db: uniprot

Branched-chain-amino-acid aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot Q5EA40 45
organism: Bos taurus

ncbitaxon 10090 21
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot Q7NGK1 128
type: UnificationXref
id: Q7NGK1
db: uniprot

Acetolactate synthase-like protein
type: ProteinReference
xref: uniprot A1L0T0 85
organism: Homo sapiens

uniprot Q8ZTD9 112
type: UnificationXref
id: Q8ZTD9
db: uniprot

uniprot P54691 37
type: UnificationXref
id: P54691
db: uniprot

ncbitaxon 208964 25
type: UnificationXref
id: 208964
db: ncbitaxon

Ketol-acid reductoisomerase
type: ProteinReference
xref: P02996
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Ketol-acid reductoisomerase Synonym: Synonym not specified Accession: P02996
comment: ENTITY_REFERENCE_ID_DESC=Isoleucine biosynthesis.PROTEIN.GENERIC.Ketol-acid_br_reductoisomerase
member entity reference: Ketol-acid reductoisomerase (NADP(+))
member entity reference: Ketol-acid reductoisomerase, mitochondrial
member entity reference: Probable ketol-acid reductoisomerase, mitochondrial
member entity reference: Ketol-acid reductoisomerase (NADP(+)) 1
member entity reference: Ketol-acid reductoisomerase, chloroplastic
member entity reference: Ketol-acid reductoisomerase (NADP(+)) 2

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 42

ncbitaxon 7227 64
type: UnificationXref
id: 7227
db: ncbitaxon

Acetolactate synthase large subunit IlvG
type: ProteinReference
xref: uniprot P9WG39 100
organism: Mycobacterium tuberculosis

ncbitaxon 9606 15
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot P37253 68
type: UnificationXref
id: P37253
db: uniprot

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 78

ncbitaxon 189518 133
type: UnificationXref
id: 189518
db: ncbitaxon

Acetolactate synthase
type: ProteinReference
xref: uniprot Q9HVA0 113
organism: Pseudomonas aeruginosa

ncbitaxon 1111708 38
type: UnificationXref
id: 1111708
db: ncbitaxon

ncbitaxon 39947 47
type: UnificationXref
id: 39947
db: ncbitaxon

Acetolactate synthase isozyme 1 large subunit
type: ProteinReference
xref: uniprot P08142 95
organism: Escherichia coli

Ketol-acid reductoisomerase, mitochondrial
type: ProteinReference
xref: uniprot P38674 69
organism: Neurospora crassa

Branched-chain-amino-acid aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot O35854 18
organism: Rattus norvegicus

uniprot Q9LE06 56
type: UnificationXref
id: Q9LE06
db: uniprot

ncbitaxon 214684 106
type: UnificationXref
id: 214684
db: ncbitaxon

Acetolactate synthase, mitochondrial
type: ProteinReference
xref: uniprot Q5KPJ5 105
organism: Cryptococcus neoformans

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 71

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot H2QGS7 13
organism: Pan troglodytes

STATE_TRANSITION_LEFT__2,3_dihydroxy_3_methylvalerate-RIGHT__H2O-_2_keto_3_methyl_valerate-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 157
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 159
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 158
left: 2,3-dihydroxy-3-methylvalerate
interaction type: STATE_TRANSITION
right: 2-keto-3-methyl-valerate
right: H2O

Isoleucine biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__H2O-_threonine-RIGHT__2_oxobutanoate-_NH3-_r1
pathway component: STATE_TRANSITION_LEFT__pyruvate-_2_oxobutanoate-RIGHT__CO2-_2_aceto_2_hydroxy_butyrate-_r2
pathway component: STATE_TRANSITION_LEFT__NADPH-_2_aceto_2_hydroxy_butyrate-RIGHT__2,3_dihydroxy_3_methylvalerate-_NADP-_r3
pathway component: STATE_TRANSITION_LEFT__2,3_dihydroxy_3_methylvalerate-RIGHT__H2O-_2_keto_3_methyl_valerate-_r4
pathway component: STATE_TRANSITION_LEFT__glutamate-_2_keto_3_methyl_valerate-RIGHT__2_oxoglutarate-_isoleucine-_r5
xref: PANTHER Pathway P02748 1
comment: MODEL_NOTES= The biosynthesis of the amino acid isoleucine, critical to protein synthesis. Website=www.biocyc.org/Ecoli/Pathways/ free text=Biochemistry (text) Voet and Voet

ncbitaxon 243230 62
type: UnificationXref
id: 243230
db: ncbitaxon

ncbitaxon 284812 71
type: UnificationXref
id: 284812
db: ncbitaxon

Acetolactate synthase-like protein
type: ProteinReference
xref: uniprot F6YYE8 90
organism: Macaca mulatta

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot O86428 24
organism: Pseudomonas aeruginosa

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 5

Acetolactate synthase 1, chloroplastic
type: ProteinReference
xref: uniprot Q6K2E8 107
organism: Oryza sativa

uniprot P06168 67
type: UnificationXref
id: P06168
db: uniprot

NADPH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: uniprot Q7NH80 73
organism: Gloeobacter violaceus

Putative acetolactate synthase
type: ProteinReference
xref: uniprot Q9RDF9 116
organism: Streptomyces coelicolor

uniprot A0A1D5Q6Y3 2
type: UnificationXref
id: A0A1D5Q6Y3
db: uniprot

uniprot Q8TKM8 134
type: UnificationXref
id: Q8TKM8
db: uniprot

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot O69198 121
organism: Streptomyces coelicolor

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot P9WQ75 39
organism: Mycobacterium tuberculosis

uniprot P17597 97
type: UnificationXref
id: P17597
db: uniprot

ncbitaxon 3702 57
type: UnificationXref
id: 3702
db: ncbitaxon

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q1K779 41
organism: Neurospora crassa

uniprot O66759 93
type: UnificationXref
id: O66759
db: uniprot

uniprot Q1K779 41
type: UnificationXref
id: Q1K779
db: uniprot

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: uniprot P37253 68
organism: Bacillus subtilis

Probable ketol-acid reductoisomerase, mitochondrial
type: ProteinReference
xref: uniprot P78827 70
organism: Schizosaccharomyces pombe

uniprot Q9RU76 117
type: UnificationXref
id: Q9RU76
db: uniprot

uniprot Q9FBT8 80
type: UnificationXref
id: Q9FBT8
db: uniprot

Acetolactate synthase, chloroplastic
type: ProteinReference
xref: uniprot P17597 97
organism: Arabidopsis thaliana

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q9VYD5 63
organism: Drosophila melanogaster

ncbitaxon 10116 19
type: UnificationXref
id: 10116
db: ncbitaxon

Acetolactate synthase large subunit
type: ProteinReference
xref: uniprot P37251 99
organism: Bacillus subtilis

Branched-chain-amino-acid aminotransferase 2
type: ProteinReference
xref: uniprot P39576 31
organism: Bacillus subtilis

Acetolactate synthase
type: ProteinReference
xref: uniprot Q8TJJ2 109
organism: Methanosarcina acetivorans

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 133

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot P51785 124
organism: Bacillus subtilis

uniprot Q9RJZ4 137
type: UnificationXref
id: Q9RJZ4
db: uniprot

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 62

ncbitaxon 7165 49
type: UnificationXref
id: 7165
db: ncbitaxon

D-xylonate dehydratase YagF
type: ProteinReference
xref: uniprot P77596 125
organism: Escherichia coli

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 15

uniprot Q9RTX5 61
type: UnificationXref
id: Q9RTX5
db: uniprot

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 44

uniprot Q9LPM9 59
type: UnificationXref
id: Q9LPM9
db: uniprot

CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Threonine dehydratase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot A0A1D5Q6Y3 2
organism: Macaca mulatta

IlvB acetolactate synthase like
type: ProteinReference
xref: uniprot F1Q255 89
organism: Canis lupus familiaris

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 57

uniprot O67289 66
type: UnificationXref
id: O67289
db: uniprot

glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q9RTX5 61
organism: Deinococcus radiodurans

STATE_TRANSITION_LEFT__H2O-_threonine-RIGHT__2_oxobutanoate-_NH3-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 150
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 151
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 152
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 149
left: threonine
left: H2O
interaction type: STATE_TRANSITION
right: NH3
right: 2-oxobutanoate

Acetolactate synthase
type: ProteinReference
xref: uniprot Q8ZTD9 112
organism: Pyrobaculum aerophilum

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q9HNF8 54
organism: Halobacterium salinarum

uniprot Q8TJJ4 79
type: UnificationXref
id: Q8TJJ4
db: uniprot

uniprot Q04789 102
type: UnificationXref
id: Q04789
db: uniprot

ILVBL isoform 1
type: ProteinReference
xref: uniprot H2QFL7 91
organism: Pan troglodytes

uniprot P37251 99
type: UnificationXref
id: P37251
db: uniprot

uniprot Q8TJJ2 109
type: UnificationXref
id: Q8TJJ2
db: uniprot

Acetolactate synthase-like protein
type: ProteinReference
xref: uniprot Q8BU33 108
organism: Mus musculus

ncbitaxon 251221 74
type: UnificationXref
id: 251221
db: ncbitaxon

uniprot Q9M401 60
type: UnificationXref
id: Q9M401
db: uniprot

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 40

ncbitaxon 83332 40
type: UnificationXref
id: 83332
db: ncbitaxon

uniprot P39522 123
type: UnificationXref
id: P39522
db: uniprot

ncbitaxon 6239 35
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot P07342 94
type: UnificationXref
id: P07342
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__pyruvate-_2_oxobutanoate-RIGHT__CO2-_2_aceto_2_hydroxy_butyrate-_r2
controller: Acetolactate synthase

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 96

uniprot D4ACG2 88
type: UnificationXref
id: D4ACG2
db: uniprot

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot F6ZG49 12
organism: Macaca mulatta

uniprot Q9RV97 138
type: UnificationXref
id: Q9RV97
db: uniprot

uniprot H2QFL7 91
type: UnificationXref
id: H2QFL7
db: uniprot

Branched-chain-amino-acid aminotransferase 3, chloroplastic
type: ProteinReference
xref: uniprot Q9M401 60
organism: Arabidopsis thaliana

Acetolactate synthase, large subunit
type: ProteinReference
xref: uniprot Q8TR30 111
organism: Methanosarcina acetivorans

uniprot Q8A612 77
type: UnificationXref
id: Q8A612
db: uniprot

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q8ZTE2 52
organism: Pyrobaculum aerophilum

ncbitaxon 224324 23
type: UnificationXref
id: 224324
db: ncbitaxon

uniprot A0A2I3RE03 4
type: UnificationXref
id: A0A2I3RE03
db: uniprot

NADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Branched chain amino acid aminotransferase
type: Protein
entity reference: Branched chain amino acid aminotransferase
comment: SPECIES_TYPE=PROTEIN

uniprot Q7UKY0 75
type: UnificationXref
id: Q7UKY0
db: uniprot

Branched-chain-amino-acid aminotransferase, cytosolic
type: ProteinReference
xref: uniprot P54690 36
organism: Rattus norvegicus

ncbitaxon 243274 83
type: UnificationXref
id: 243274
db: ncbitaxon

uniprot A8WUX0 87
type: UnificationXref
id: A8WUX0
db: uniprot

ncbitaxon 178306 53
type: UnificationXref
id: 178306
db: ncbitaxon

uniprot Q7UJ69 130
type: UnificationXref
id: Q7UJ69
db: uniprot

uniprot P77596 125
type: UnificationXref
id: P77596
db: uniprot

Probable branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot P54691 37
organism: Synechocystis

Putative dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q9RJZ4 137
organism: Streptomyces coelicolor

ncbitaxon 243232 44
type: UnificationXref
id: 243232
db: ncbitaxon

NH3
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9LPM8 58
type: UnificationXref
id: Q9LPM8
db: uniprot

STATE_TRANSITION_LEFT__pyruvate-_2_oxobutanoate-RIGHT__CO2-_2_aceto_2_hydroxy_butyrate-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 145
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 147
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 148
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 146
left: 2-oxobutanoate
left: pyruvate
interaction type: STATE_TRANSITION
right: 2-aceto-2-hydroxy butyrate
right: CO2

uniprot A8WM75 8
type: UnificationXref
id: A8WM75
db: uniprot

Branched-chain-amino-acid aminotransferase, cytosolic
type: ProteinReference
xref: uniprot P54688 34
organism: Caenorhabditis elegans

Ketol-acid reductoisomerase (NADP(+)) 1
type: ProteinReference
xref: uniprot Q9Z565 84
organism: Streptomyces coelicolor

uniprot P38674 69
type: UnificationXref
id: P38674
db: uniprot

Acetolactate synthase
type: ProteinReference
xref: uniprot Q9Z567 119
organism: Streptomyces coelicolor

PARTICIPANT STOICHIOMETRY r3 143
type: Stoichiometry
physical entity: 2,3-dihydroxy-3-methylvalerate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 144
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 141
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 142
type: Stoichiometry
physical entity: 2-aceto-2-hydroxy butyrate
stoichiometric coefficient: 1.0

uniprot O61856 92
type: UnificationXref
id: O61856
db: uniprot

P02997
type: UnificationXref
id: P02997
db: PANTHER Pathway Component

P02996
type: UnificationXref
id: P02996
db: PANTHER Pathway Component

uniprot Q9RDF9 116
type: UnificationXref
id: Q9RDF9
db: uniprot

P02998
type: UnificationXref
id: P02998
db: PANTHER Pathway Component

Acetolactate synthase
type: ProteinReference
xref: uniprot Q9WZ18 118
organism: Thermotoga maritima

P02994
type: UnificationXref
id: P02994
db: PANTHER Pathway Component

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 17

uniprot Q9Z567 119
type: UnificationXref
id: Q9Z567
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 7

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__2,3_dihydroxy_3_methylvalerate-RIGHT__H2O-_2_keto_3_methyl_valerate-_r4
controller: Dihydroxyacid dehydratase

uniprot Q8TPF5 110
type: UnificationXref
id: Q8TPF5
db: uniprot

uniprot F6ZG49 12
type: UnificationXref
id: F6ZG49
db: uniprot

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q7NGK1 128
organism: Gloeobacter violaceus

Branched-chain-amino-acid aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot O15382 14
organism: Homo sapiens

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 3

Probable branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot O86505 26
organism: Streptomyces coelicolor

ncbitaxon 100226 27
type: UnificationXref
id: 100226
db: ncbitaxon

Probable decarboxylase
type: ProteinReference
xref: uniprot Q9I280 115
organism: Pseudomonas aeruginosa

Branched-chain-amino-acid aminotransferase, cytosolic
type: ProteinReference
xref: uniprot P47176 32
organism: Saccharomyces cerevisiae

Dihydroxyacid dehydratase
type: ProteinReference
xref: P02998
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Isoleucine biosynthesis.PROTEIN.GENERIC.Dihydroxyacid dehydratase
comment: ENTITY_REFERENCE_NOTES= Long Name: Dihydroxyacid dehydratase Synonym: Synonym not specified Accession: P02998
member entity reference: Dihydroxy-acid dehydratase
member entity reference: Putative dihydroxy-acid dehydratase
member entity reference: Dihydroxy-acid dehydratase 1
member entity reference: Dihydroxy-acid dehydratase, mitochondrial
member entity reference: D-xylonate dehydratase YagF
member entity reference: Dihydroxy-acid dehydratase, chloroplastic
member entity reference: D-xylonate dehydratase YjhG
member entity reference: Putative dihydroxy-acid dehydratase, mitochondrial
member entity reference: Dihydroxy-acid dehydratase 2

uniprot O35854 18
type: UnificationXref
id: O35854
db: uniprot

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q9RV97 138
organism: Deinococcus radiodurans

Uncharacterized protein MJ0663
type: ProteinReference
xref: uniprot Q58077 104
organism: Methanocaldococcus jannaschii

uniprot F1PY28 10
type: UnificationXref
id: F1PY28
db: uniprot

uniprot Q9LIR4 136
type: UnificationXref
id: Q9LIR4
db: uniprot

ncbitaxon 9598 5
type: UnificationXref
id: 9598
db: ncbitaxon

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot O67009 120
organism: Aquifex aeolicus

uniprot O86428 24
type: UnificationXref
id: O86428
db: uniprot

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q8F219 132
organism: Leptospira interrogans

uniprot P78827 70
type: UnificationXref
id: P78827
db: uniprot

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 51

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q9WZ21 139
organism: Thermotoga maritima

uniprot O67733 22
type: UnificationXref
id: O67733
db: uniprot

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: uniprot Q9WZ20 82
organism: Thermotoga maritima

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__glutamate-_2_keto_3_methyl_valerate-RIGHT__2_oxoglutarate-_isoleucine-_r5
controller: Branched chain amino acid aminotransferase

ncbitaxon 367110 42
type: UnificationXref
id: 367110
db: ncbitaxon

D-xylonate dehydratase YjhG
type: ProteinReference
xref: uniprot P39358 122
organism: Escherichia coli

ncbitaxon 9615 11
type: UnificationXref
id: 9615
db: ncbitaxon

2-oxobutanoate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Acetolactate synthase catalytic subunit, mitochondrial
type: ProteinReference
xref: uniprot P07342 94
organism: Saccharomyces cerevisiae

uniprot Q9HWK1 114
type: UnificationXref
id: Q9HWK1
db: uniprot

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: uniprot O67289 66
organism: Aquifex aeolicus

uniprot Q9WZ20 82
type: UnificationXref
id: Q9WZ20
db: uniprot

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q1K658 127
organism: Neurospora crassa

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 19

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 23

Putative dihydroxy-acid dehydratase, mitochondrial
type: ProteinReference
xref: uniprot Q10318 126
organism: Schizosaccharomyces pombe

uniprot P24288 28
type: UnificationXref
id: P24288
db: uniprot

uniprot Q8BU33 108
type: UnificationXref
id: Q8BU33
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 11

2-keto-3-methyl-valerate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ketol-acid reductoisomerase
type: Protein
entity reference: Ketol-acid reductoisomerase
comment: SPECIES_TYPE=PROTEIN

Branched-chain-amino-acid aminotransferase, cytosolic
type: ProteinReference
xref: uniprot P54687 33
organism: Homo sapiens

uniprot Q8TI08 50
type: UnificationXref
id: Q8TI08
db: uniprot

ncbitaxon 83333 96
type: UnificationXref
id: 83333
db: ncbitaxon

uniprot Q8ZTE2 52
type: UnificationXref
id: Q8ZTE2
db: uniprot

uniprot Q10318 126
type: UnificationXref
id: Q10318
db: uniprot

uniprot Q5KPJ5 105
type: UnificationXref
id: Q5KPJ5
db: uniprot

Acetolactate synthase
type: ProteinReference
xref: uniprot Q04789 102
organism: Bacillus subtilis

uniprot H2QGS7 13
type: UnificationXref
id: H2QGS7
db: uniprot

uniprot O35855 20
type: UnificationXref
id: O35855
db: uniprot

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: uniprot Q8TJJ4 79
organism: Methanosarcina acetivorans

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q7UJ69 130
organism: Rhodopirellula baltica

uniprot P36620 98
type: UnificationXref
id: P36620
db: uniprot

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: uniprot Q9RU74 81
organism: Deinococcus radiodurans

Acetolactate synthase
type: ProteinReference
xref: uniprot Q9RU76 117
organism: Deinococcus radiodurans

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 53

uniprot P54690 36
type: UnificationXref
id: P54690
db: uniprot

ncbitaxon 9913 7
type: UnificationXref
id: 9913
db: ncbitaxon

ncbitaxon 226186 78
type: UnificationXref
id: 226186
db: ncbitaxon

uniprot Q58077 104
type: UnificationXref
id: Q58077
db: uniprot

Putative branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q58414 43
organism: Methanocaldococcus jannaschii

uniprot O15382 14
type: UnificationXref
id: O15382
db: uniprot

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 76

PARTICIPANT STOICHIOMETRY r4 157
type: Stoichiometry
physical entity: 2,3-dihydroxy-3-methylvalerate
stoichiometric coefficient: 1.0

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 27

PARTICIPANT STOICHIOMETRY r4 158
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 149
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Dihydroxy-acid dehydratase 2
type: ProteinReference
xref: uniprot Q8TKM8 134
organism: Methanosarcina acetivorans

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: uniprot Q8A612 77
organism: Bacteroides thetaiotaomicron

PARTICIPANT STOICHIOMETRY r4 159
type: Stoichiometry
physical entity: 2-keto-3-methyl-valerate
stoichiometric coefficient: 1.0

uniprot O69198 121
type: UnificationXref
id: O69198
db: uniprot

PARTICIPANT STOICHIOMETRY r5 156
type: Stoichiometry
physical entity: isoleucine
stoichiometric coefficient: 1.0

uniprot Q9Z565 84
type: UnificationXref
id: Q9Z565
db: uniprot

PARTICIPANT STOICHIOMETRY r5 154
type: Stoichiometry
physical entity: 2-keto-3-methyl-valerate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 155
type: Stoichiometry
physical entity: 2-oxoglutarate
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

ncbitaxon 224308 17
type: UnificationXref
id: 224308
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r5 153
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

uniprot Q05758 72
type: UnificationXref
id: Q05758
db: uniprot

PARTICIPANT STOICHIOMETRY r1 152
type: Stoichiometry
physical entity: NH3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 151
type: Stoichiometry
physical entity: 2-oxobutanoate
stoichiometric coefficient: 1.0

Acetolactate synthase-like protein
type: ProteinReference
xref: uniprot O61856 92
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r1 150
type: Stoichiometry
physical entity: threonine
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_threonine-RIGHT__2_oxobutanoate-_NH3-_r1
controller: Threonine dehydratase

uniprot Q7SBQ5 129
type: UnificationXref
id: Q7SBQ5
db: uniprot

uniprot Q9HVA0 113
type: UnificationXref
id: Q9HVA0
db: uniprot

uniprot Q58414 43
type: UnificationXref
id: Q58414
db: uniprot

uniprot Q9VYD5 63
type: UnificationXref
id: Q9VYD5
db: uniprot

uniprot O86505 26
type: UnificationXref
id: O86505
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH-_2_aceto_2_hydroxy_butyrate-RIGHT__2,3_dihydroxy_3_methylvalerate-_NADP-_r3
controller: Ketol-acid reductoisomerase

uniprot P47176 32
type: UnificationXref
id: P47176
db: uniprot

2-oxoglutarate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Probable acetolactate synthase large subunit
type: ProteinReference
xref: uniprot Q9HWK1 114
organism: Pseudomonas aeruginosa

Probable acetolactate synthase large subunit
type: ProteinReference
xref: uniprot Q57725 103
organism: Methanocaldococcus jannaschii

Dihydroxy-acid dehydratase 1
type: ProteinReference
xref: uniprot Q8TPV2 135
organism: Methanosarcina acetivorans

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot A8WM75 8
organism: Caenorhabditis briggsae

STATE_TRANSITION_LEFT__NADPH-_2_aceto_2_hydroxy_butyrate-RIGHT__2,3_dihydroxy_3_methylvalerate-_NADP-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 143
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 142
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 141
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 144
left: 2-aceto-2-hydroxy butyrate
left: NADPH
interaction type: STATE_TRANSITION
right: NADP
right: 2,3-dihydroxy-3-methylvalerate

uniprot P9WQ75 39
type: UnificationXref
id: P9WQ75
db: uniprot

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q8TI08 50
organism: Methanosarcina acetivorans

2,3-dihydroxy-3-methylvalerate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 188937 51
type: UnificationXref
id: 188937
db: ncbitaxon

Branched-chain-amino-acid aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot P38891 29
organism: Saccharomyces cerevisiae

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 9

Branched-chain-amino-acid aminotransferase, cytosolic
type: ProteinReference
xref: uniprot P24288 28
organism: Mus musculus

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 35

uniprot P39576 31
type: UnificationXref
id: P39576
db: uniprot

IlvB (Bacterial acetolactate synthase)-like (Predicted), isoform CRA_c
type: ProteinReference
xref: uniprot D4ACG2 88
organism: Rattus norvegicus

pyruvate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8TR30 111
type: UnificationXref
id: Q8TR30
db: uniprot

uniprot P51785 124
type: UnificationXref
id: P51785
db: uniprot

ncbitaxon 9544 3
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot Q1K658 127
type: UnificationXref
id: Q1K658
db: uniprot

2-aceto-2-hydroxy butyrate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P08142 95
type: UnificationXref
id: P08142
db: uniprot

uniprot A0A3Q1ML78 6
type: UnificationXref
id: A0A3Q1ML78
db: uniprot

Dihydroxy-acid dehydratase
type: ProteinReference
xref: uniprot Q8A608 131
organism: Bacteroides thetaiotaomicron

Acetolactate synthase, mitochondrial
type: ProteinReference
xref: uniprot P36620 98
organism: Schizosaccharomyces pombe

PANTHER Pathway P02748 1
type: UnificationXref
id: P02748
db: PANTHER Pathway

uniprot F6YYE8 90
type: UnificationXref
id: F6YYE8
db: uniprot

Dihydroxyacid dehydratase
type: Protein
entity reference: Dihydroxyacid dehydratase
comment: SPECIES_TYPE=PROTEIN

uniprot Q9HNF8 54
type: UnificationXref
id: Q9HNF8
db: uniprot

uniprot Q8TPV2 135
type: UnificationXref
id: Q8TPV2
db: uniprot

uniprot P9WG39 100
type: UnificationXref
id: P9WG39
db: uniprot

Acetolactate synthase large subunit IlvB1
type: ProteinReference
xref: uniprot P9WG41 101
organism: Mycobacterium tuberculosis

Acetolactate synthase
type: ProteinReference
xref: P02997
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Isoleucine biosynthesis.PROTEIN.GENERIC.Acetolactate synthase
comment: ENTITY_REFERENCE_NOTES= Long Name: Acetolactate synthase Synonym: Synonym not specified Accession: P02997
member entity reference: Acetolactate synthase
member entity reference: Probable acetolactate synthase large subunit
member entity reference: Acetolactate synthase, large subunit
member entity reference: Acetolactate synthase, mitochondrial
member entity reference: Acetolactate synthase-like protein
member entity reference: Acetolactate synthase large subunit
member entity reference: Acetolactate synthase 1, chloroplastic
member entity reference: Putative acetolactate synthase
member entity reference: Acetolactate synthase isozyme 1 large subunit
member entity reference: IlvB acetolactate synthase like
member entity reference: Acetolactate synthase large subunit IlvG
member entity reference: Acetolactate synthase, chloroplastic
member entity reference: Protein CBG03380
member entity reference: Acetolactate synthase catalytic subunit, mitochondrial
member entity reference: ILVBL isoform 1
member entity reference: Probable decarboxylase
member entity reference: Uncharacterized protein MJ0663
member entity reference: Acetolactate synthase large subunit IlvB1
member entity reference: IlvB (Bacterial acetolactate synthase)-like (Predicted), isoform CRA_c

Protein CBG03380
type: ProteinReference
xref: uniprot A8WUX0 87
organism: Caenorhabditis briggsae

ncbitaxon 559292 30
type: UnificationXref
id: 559292
db: ncbitaxon

Ketol-acid reductoisomerase (NADP(+)) 2
type: ProteinReference
xref: uniprot Q9FBT8 80
organism: Streptomyces coelicolor

Ketol-acid reductoisomerase (NADP(+))
type: ProteinReference
xref: uniprot Q7UKY0 75
organism: Rhodopirellula baltica

uniprot P39358 122
type: UnificationXref
id: P39358
db: uniprot

uniprot A6QQT9 86
type: UnificationXref
id: A6QQT9
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 47

Ketol-acid reductoisomerase, chloroplastic
type: ProteinReference
xref: uniprot Q05758 72
organism: Arabidopsis thaliana

uniprot F1Q255 89
type: UnificationXref
id: F1Q255
db: uniprot

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 25

uniprot Q8F219 132
type: UnificationXref
id: Q8F219
db: uniprot

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q6AT43 46
organism: Oryza sativa