S STAT s41 a41 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S STAT s41 a41 rs2 S
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.868219525848657

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F7CW94 30
xref: PTHR11801:SF19
organism: Monodelphis domestica

Cytokine s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cytokine
stoichiometric coefficient: 1.0

Y STAT s21 a19 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y STAT s21 a19 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.476222116492287
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot F7DN97 90
type: UnificationXref
id: F7DN97
db: uniprot

Gene transcription
type: Pathway

uniprot K7AQ66 97
type: UnificationXref
id: K7AQ66
db: uniprot

uniprot A0A2J8LTH4 113
type: UnificationXref
id: A0A2J8LTH4
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot F1NMJ9 118
organism: Gallus gallus

uniprot G3V9T0 95
type: UnificationXref
id: G3V9T0
db: uniprot

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 3

uniprot F6UMM2 24
type: UnificationXref
id: F6UMM2
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E1BEL4 115
xref: PTHR45807:SF3
organism: Bos taurus

Tyrosine-protein kinase JAK2
type: ProteinReference
xref: uniprot Q62689 133
xref: PTHR45807:SF1
organism: Rattus norvegicus

STAT s9 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

uniprot P52631 49
type: UnificationXref
id: P52631
db: uniprot

E3 SUMO-protein ligase PIAS2
type: ProteinReference
xref: uniprot O75928 102
xref: PTHR10782:SF12
organism: Homo sapiens

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot F7BQ11 25
organism: Gallus gallus

E3 SUMO-protein ligase PIAS1
type: ProteinReference
xref: PTHR10782:SF11
xref: uniprot O75925 101
organism: Homo sapiens

uniprot B5DFF9 83
type: UnificationXref
id: B5DFF9
db: uniprot

uniprot Q6AZ28 104
type: UnificationXref
id: Q6AZ28
db: uniprot

STATE_TRANSITION_LEFT__ATP-_Jak-RIGHT__Jak-_ADP-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 153
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 152
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 155
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 154
left: ATP
left: Jak
interaction type: STATE_TRANSITION
right: Jak
right: ADP

uniprot E2RB82 15
type: UnificationXref
id: E2RB82
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 41

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot G3V9W2 124
organism: Rattus norvegicus

Cytokine Receptor s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cytokine Receptor
stoichiometric coefficient: 1.0

uniprot P08575 111
type: UnificationXref
id: P08575
db: uniprot

uniprot A0A3Q1ML58 81
type: UnificationXref
id: A0A3Q1ML58
db: uniprot

PARTICIPANT STOICHIOMETRY r39 166
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r39 165
type: Stoichiometry
physical entity: Complex (Cytokine Receptor/Cytokine/ Jak)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r39 164
type: Stoichiometry
physical entity: Complex (Cytokine Receptor/Cytokine/ STAT/Jak)
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription 2
type: ProteinReference
xref: PTHR11801:SF41
xref: uniprot Q9WVL2 59
organism: Mus musculus

uniprot Q9Y6X2 107
type: UnificationXref
id: Q9Y6X2
db: uniprot

uniprot A0A2I3SSB8 79
type: UnificationXref
id: A0A2I3SSB8
db: uniprot

uniprot F6V332 64
type: UnificationXref
id: F6V332
db: uniprot

PTP
type: ProteinReference
xref: P01033
standard name: protein-tyrosine phosphatase
comment: ENTITY_REFERENCE_NOTES= Long Name: protein-tyrosine phosphatase Synonym: PTP Accession: P01033
comment: ENTITY_REFERENCE_ID_DESC=JAK/STAT signaling pathway.PROTEIN.GENERIC.PTP
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Receptor-type tyrosine-protein phosphatase C
member entity reference: PTPRC isoform 2
member entity reference: Uncharacterized protein

uniprot O54714 99
type: UnificationXref
id: O54714
db: uniprot

ADP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F1PIY7 119
type: UnificationXref
id: F1PIY7
db: uniprot

Receptor-type tyrosine-protein phosphatase C
type: ProteinReference
xref: PTHR19134:SF284
xref: uniprot P04157 110
organism: Rattus norvegicus

uniprot F1QWX8 120
type: UnificationXref
id: F1QWX8
db: uniprot

uniprot Q9QX78 78
type: UnificationXref
id: Q9QX78
db: uniprot

S STAT s49 a73 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S STAT s49 a73 rs2 S
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.868219525848657

PARTICIPANT STOICHIOMETRY r37 175
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r37 176
type: Stoichiometry
physical entity: Jak
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A1D5QPR1 8
xref: PTHR11801:SF47
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r37 174
type: Stoichiometry
physical entity: Complex (Cytokine Receptor/Cytokine)
stoichiometric coefficient: 1.0

uniprot O93599 35
type: UnificationXref
id: O93599
db: uniprot

uniprot F1N0D6 117
type: UnificationXref
id: F1N0D6
db: uniprot

PARTICIPANT STOICHIOMETRY r37 177
type: Stoichiometry
physical entity: Complex (Cytokine Receptor/Cytokine/ Jak)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r37 178
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot F6YUL3 88
type: UnificationXref
id: F6YUL3
db: uniprot

ncbitaxon 9031 26
type: UnificationXref
id: 9031
db: ncbitaxon

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF48
xref: uniprot K7D3K8 34
organism: Pan troglodytes

Cytokine
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa4 149
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F6WH53 121
type: UnificationXref
id: F6WH53
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot F7D2D3 31
organism: Monodelphis domestica

Jak s10 sa9 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.87350024439705
comment: MODIFICATION_RESIDUE_NAME=

Signal transducer and activator of transcription 4
type: ProteinReference
xref: uniprot Q14765 53
xref: PTHR11801:SF19
organism: Homo sapiens

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A2I3TQ88 14
xref: PTHR11801:SF2
organism: Pan troglodytes

uniprot P52632 51
type: UnificationXref
id: P52632
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 13

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 23

Protein inhibitor of activated STAT 1 (Predicted)
type: ProteinReference
xref: PTHR10782:SF11
xref: uniprot G3V9T0 95
organism: Rattus norvegicus

E3 SUMO-protein ligase PIAS3
type: ProteinReference
xref: PTHR10782:SF10
xref: uniprot Q9Y6X2 107
organism: Homo sapiens

PIAS
type: Protein
entity reference: PIAS
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DDM9 89
xref: PTHR10782:SF12
organism: Monodelphis domestica

uniprot F1NMJ9 118
type: UnificationXref
id: F1NMJ9
db: uniprot

uniprot F7GT47 123
type: UnificationXref
id: F7GT47
db: uniprot

uniprot F1NSG6 86
type: UnificationXref
id: F1NSG6
db: uniprot

uniprot P42225 40
type: UnificationXref
id: P42225
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot F1PIY7 119
organism: Canis lupus familiaris

uniprot P42227 43
type: UnificationXref
id: P42227
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__Cytokine_Receptor_Cytokine_-_ATP-_Jak-RIGHT__Complex__Cytokine_Receptor_Cytokine__Jak_-_ADP-_r37
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 177
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 175
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 174
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 178
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 176
left: Jak
left: ATP
left: Complex (Cytokine Receptor/Cytokine)
interaction type: HETERODIMER_ASSOCIATION
right: ADP
right: Complex (Cytokine Receptor/Cytokine/ Jak)

PARTICIPANT STOICHIOMETRY r40 173
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

STAT
type: ProteinReference
xref: P01027
standard name: Signal transducers and activators of transcription
comment: ENTITY_REFERENCE_NOTES= Long Name: Signal transducers and activators of transcription Synonym: STAT Accession: P01027
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=JAK/STAT signaling pathway.PROTEIN.GENERIC.STAT
member entity reference: Signal transducer and activator of transcription
member entity reference: Signal transducer and activator of transcription 5A
member entity reference: Signal transducer and activator of transcription 3
member entity reference: Signal transducer and activator of transcription 5B
member entity reference: Signal transducer and activator of transcription 1
member entity reference: Signal transducer and activator of transcription 1-alpha/beta
member entity reference: Signal transducer and activator of transcription 6
member entity reference: Signal transducer and activator of transcription 4
member entity reference: Signal transducer and transcription activator 6
member entity reference: Signal transducer and activator of transcription 2

uniprot Q9DGE1 71
type: UnificationXref
id: Q9DGE1
db: uniprot

uniprot A0A140T878 4
type: UnificationXref
id: A0A140T878
db: uniprot

uniprot P47811 67
type: UnificationXref
id: P47811
db: uniprot

PARTICIPANT STOICHIOMETRY r3 154
type: Stoichiometry
physical entity: Jak
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 155
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 152
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

ncbitaxon 7955 36
type: UnificationXref
id: 7955
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r3 153
type: Stoichiometry
physical entity: Jak
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__2_ATP-_Complex__Cytokine_Receptor_Cytokine__Jak_-_STAT-RIGHT__Complex__Cytokine_Receptor_Cytokine__STAT_Jak_-_2_ADP-_r38
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 167
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 169
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 171
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 170
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 168
left: 2 ATP
left: STAT
left: Complex (Cytokine Receptor/Cytokine/ Jak)
interaction type: HETERODIMER_ASSOCIATION
right: 2 ADP
right: Complex (Cytokine Receptor/Cytokine/ STAT/Jak)

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot F6T2X3 22
organism: Xenopus tropicalis

Jak
type: Protein
entity reference: Jak
feature: ACTIVE 60
feature: Jak s18 a8 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Protein inhibitor of activated STAT 1
type: ProteinReference
xref: PTHR10782:SF11
xref: uniprot F1PQ60 87
organism: Canis lupus familiaris

Cytokine Receptor
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 147
feature: Cytokine Receptor s3 sa3 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r40 172
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot A0A2J8LTH4 113
xref: PTHR45807:SF3
organism: Pan troglodytes

JAK/STAT signaling pathway
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__2_ATP-_Complex__Cytokine_Receptor_Cytokine__Jak_-_STAT-RIGHT__Complex__Cytokine_Receptor_Cytokine__STAT_Jak_-_2_ADP-_r38
pathway component: TRANSPORT_LEFT__STAT-RIGHT__STAT-_r41
pathway component: PHYSICAL_STIMULATION
pathway component: DISSOCIATION_LEFT__Complex__Cytokine_Receptor_Cytokine__STAT_Jak_-RIGHT__Complex__Cytokine_Receptor_Cytokine__Jak_-_STAT-_r39
pathway component: HETERODIMER_ASSOCIATION_LEFT__Cytokine_Receptor-_Cytokine-RIGHT__Complex__Cytokine_Receptor_Cytokine_-_r35
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Cytokine_Receptor_Cytokine_-_ATP-_Jak-RIGHT__Complex__Cytokine_Receptor_Cytokine__Jak_-_ADP-_r37
pathway component: STATE_TRANSITION_LEFT__STAT-RIGHT__STAT-_r40
pathway component: STATE_TRANSITION_LEFT__STAT-RIGHT__Pi-_STAT-_r42
pathway component: STATE_TRANSITION_LEFT__Jak-RIGHT__Jak-_Pi-_r21
pathway component: STATE_TRANSITION_LEFT__ATP-_Jak-RIGHT__Jak-_ADP-_r3
xref: PANTHER Pathway P00038 1
comment: MODEL_NOTES=Panther Pathway: P00038 The Jak-STAT pathway is activated by both cytokines and interferons. This pathways allows for rapid and direct transduction of an extracellular signal into the nucleus. Signal transducers and activators of transcription (STAT) are activated by the Janus (JAK) family of tyrosine kinases. Activated STATs then dimerize, translocate to the nucleus, and mediate expression of many various gene products.

2 ATP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q95NE7 70
organism: Pan troglodytes

SOCS1 isoform 1
type: ProteinReference
xref: uniprot H2QAK6 75
organism: Pan troglodytes

uniprot Q95NE7 70
type: UnificationXref
id: Q95NE7
db: uniprot

Jak s4 a6 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.87350024439705
comment: MODIFICATION_RESIDUE_NAME=

Jak s10 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Jak
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__STAT-RIGHT__Pi-_STAT-_r42
controller: PIAS

PTHR45807:SF2
type: RelationshipXref
id: PTHR45807:SF2
db: PANTHER Family
relationship type: By Homology

PTHR45807:SF1
type: RelationshipXref
id: PTHR45807:SF1
db: PANTHER Family
relationship type: By Homology

uniprot F1MSN0 73
type: UnificationXref
id: F1MSN0
db: uniprot

PTHR45807:SF3
type: RelationshipXref
id: PTHR45807:SF3
db: PANTHER Family
relationship type: By Homology

PTHR45807:SF5
type: RelationshipXref
id: PTHR45807:SF5
db: PANTHER Family
relationship type: By Homology

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot O93599 35
organism: Danio rerio

E3 SUMO-protein ligase PIAS3
type: ProteinReference
xref: uniprot O70260 100
xref: PTHR10782:SF10
organism: Rattus norvegicus

ncbitaxon 9615 16
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot O60674 127
type: UnificationXref
id: O60674
db: uniprot

uniprot F7D2D3 31
type: UnificationXref
id: F7D2D3
db: uniprot

uniprot Q9JM05 106
type: UnificationXref
id: Q9JM05
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__STAT-RIGHT__Pi-_STAT-_r42
controller: PTP

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P40763 37
organism: Homo sapiens

Tyrosine-protein kinase JAK1
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot P23458 128
organism: Homo sapiens

Cytokine Receptor s7 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cytokine Receptor
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF48
xref: uniprot F1PAY3 20
organism: Canis lupus familiaris

uniprot F7DDM9 89
type: UnificationXref
id: F7DDM9
db: uniprot

uniprot P52333 130
type: UnificationXref
id: P52333
db: uniprot

Jak
type: Protein
entity reference: Jak
feature: Jak s4 a6 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot H2QAK6 75
type: UnificationXref
id: H2QAK6
db: uniprot

PIAS1 isoform 4
type: ProteinReference
xref: PTHR10782:SF11
xref: uniprot A0A2I3SSB8 79
organism: Pan troglodytes

Bos taurus
type: BioSource
xref: ncbitaxon 9913 5

STAT s82 a137 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 9

00696
type: UnificationXref
id: MOD:00696
db: mod

SOCS
type: ProteinReference
xref: P01030
standard name: Suppressors of cytokine signaling
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=JAK/STAT signaling pathway.PROTEIN.GENERIC.SOCS
comment: ENTITY_REFERENCE_NOTES= Long Name: Suppressors of cytokine signaling Synonym: CIS,JAB ,SOCS,SSI-1 Accession: P01030
member entity reference: Suppressor of cytokine signaling 1
member entity reference: Uncharacterized protein
member entity reference: SOCS1 isoform 1

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 91

Cytokine Receptor s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cytokine Receptor
stoichiometric coefficient: 1.0

ncbitaxon 9544 9
type: UnificationXref
id: 9544
db: ncbitaxon

Cytokine
type: Protein
comment: SPECIES_TYPE=PROTEIN

E3 SUMO-protein ligase PIAS2
type: ProteinReference
xref: uniprot Q8C5D8 105
xref: PTHR10782:SF12
organism: Mus musculus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A1D5R9X3 11
xref: PTHR11801:SF18
organism: Macaca mulatta

uniprot E2RE22 17
type: UnificationXref
id: E2RE22
db: uniprot

E3 SUMO-protein ligase PIAS1
type: ProteinReference
xref: PTHR10782:SF11
xref: uniprot O88907 103
organism: Mus musculus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot H2QD19 33
xref: PTHR11801:SF47
organism: Pan troglodytes

Cytokine Receptor
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa6 135
feature: Cytokine Receptor s7 sa6 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

DISSOCIATION
type: RelationshipTypeVocabulary

S STAT s21 a19 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S STAT s21 a19 rs2 S
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.868219525848657

uniprot A0A3Q1LPE8 80
type: UnificationXref
id: A0A3Q1LPE8
db: uniprot

uniprot O02812 66
type: UnificationXref
id: O02812
db: uniprot

Mitogen-activated protein kinase 14B
type: ProteinReference
xref: uniprot Q9DGE1 71
organism: Danio rerio

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 16

uniprot O35716 77
type: UnificationXref
id: O35716
db: uniprot

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__2_ATP-_Complex__Cytokine_Receptor_Cytokine__Jak_-_STAT-RIGHT__Complex__Cytokine_Receptor_Cytokine__STAT_Jak_-_2_ADP-_r38
controller: Complex (Cytokine Receptor/Cytokine/ Jak)

Mitogen-activated protein kinase 14A
type: ProteinReference
xref: uniprot Q9DGE2 72
organism: Danio rerio

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6YAB9 65
organism: Monodelphis domestica

uniprot A0A1D5R9X3 11
type: UnificationXref
id: A0A1D5R9X3
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot F1PNW8 21
organism: Canis lupus familiaris

By Homology
type: RelationshipTypeVocabulary

Suppressor of cytokine signaling 1
type: ProteinReference
xref: uniprot O35716 77
organism: Mus musculus

uniprot P52633 52
type: UnificationXref
id: P52633
db: uniprot

uniprot E2RPW6 116
type: UnificationXref
id: E2RPW6
db: uniprot

uniprot F7DX37 92
type: UnificationXref
id: F7DX37
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 26

ncbitaxon 9258 91
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot K7B8T0 98
type: UnificationXref
id: K7B8T0
db: uniprot

S STAT s9 sa8 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S STAT s9 sa8 rs2 S
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.868219525848657

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF1
xref: uniprot F7GT47 123
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r35 179
type: Stoichiometry
physical entity: Cytokine Receptor
stoichiometric coefficient: 1.0

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF1
xref: uniprot E1BCP6 114
organism: Bos taurus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F7CHH2 29
xref: PTHR11801:SF47
organism: Monodelphis domestica

STAT
type: Protein
entity reference: STAT
feature: ACTIVE 60
feature: Y STAT s9 sa8 rs1
feature: S STAT s9 sa8 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa8 139
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 8364 23
type: UnificationXref
id: 8364
db: ncbitaxon

Y STAT s9 sa8 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y STAT s9 sa8 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.476222116492287
comment: MODIFICATION_RESIDUE_NAME=Y

PANTHER Pathway P00038 1
type: UnificationXref
id: P00038
db: PANTHER Pathway

Protein inhibitor of activated STAT 2
type: ProteinReference
xref: uniprot F7DX37 92
xref: PTHR10782:SF12
organism: Ornithorhynchus anatinus

ncbitaxon 9913 5
type: UnificationXref
id: 9913
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GGH3 74
organism: Macaca mulatta

STATE_TRANSITION
type: RelationshipTypeVocabulary

SOCS
type: Protein
entity reference: SOCS
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Protein inhibitor of-activated STAT 1
type: ProteinReference
xref: PTHR10782:SF11
xref: uniprot F6YUL3 88
organism: Xenopus tropicalis

Signal transducer and activator of transcription 1-alpha/beta
type: ProteinReference
xref: uniprot P42224 39
xref: PTHR11801:SF18
organism: Homo sapiens

Y STAT s49 a73 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y STAT s49 a73 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.476222116492287
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot Q9WVL2 59
type: UnificationXref
id: Q9WVL2
db: uniprot

uniprot P51692 48
type: UnificationXref
id: P51692
db: uniprot

uniprot F7G8G5 32
type: UnificationXref
id: F7G8G5
db: uniprot

Pi
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__2_ATP-_Complex__Cytokine_Receptor_Cytokine__Jak_-_STAT-RIGHT__Complex__Cytokine_Receptor_Cytokine__STAT_Jak_-_2_ADP-_r38
controller: Serine kinase

PTP
type: Protein
entity reference: PTP
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r21 156
type: Stoichiometry
physical entity: Jak
stoichiometric coefficient: 1.0

Jak
type: Protein
entity reference: Jak
feature: ACTIVE 60
feature: Jak s6 sa5 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa5 151
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r21 157
type: Stoichiometry
physical entity: Jak
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r21 158
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LPE8 80
xref: PTHR10782:SF12
organism: Bos taurus

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F6WH53 121
xref: PTHR45807:SF1
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: PTHR10782:SF11
xref: uniprot F1NSG6 86
organism: Gallus gallus

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot A0A2I3SYV7 112
xref: PTHR45807:SF1
organism: Pan troglodytes

E3 SUMO-protein ligase PIAS2
type: ProteinReference
xref: uniprot Q6AZ28 104
xref: PTHR10782:SF12
organism: Rattus norvegicus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A140T878 4
xref: PTHR11801:SF39
organism: Bos taurus

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P70618 68
organism: Rattus norvegicus

Signal transducer and activator of transcription 5B
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot P42232 47
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r42 160
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r42 161
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription 5A
type: ProteinReference
xref: uniprot P42230 46
xref: PTHR11801:SF47
organism: Mus musculus

uniprot F6YLX1 122
type: UnificationXref
id: F6YLX1
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot H2PZ66 125
organism: Pan troglodytes

Tyrosine-protein kinase JAK2
type: ProteinReference
xref: uniprot O60674 127
xref: PTHR45807:SF1
organism: Homo sapiens

Protein inhibitor of activated STAT 3
type: ProteinReference
xref: uniprot E2R2U8 84
xref: PTHR10782:SF10
organism: Canis lupus familiaris

Cytokine Receptor
type: Protein
feature: Cytokine Receptor s23 a43 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Serine kinase
type: Protein
entity reference: Serine kinase
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P52332 129
type: UnificationXref
id: P52332
db: uniprot

uniprot P42228 44
type: UnificationXref
id: P42228
db: uniprot

uniprot P70618 68
type: UnificationXref
id: P70618
db: uniprot

Signal transducer and activator of transcription 5A
type: ProteinReference
xref: PTHR11801:SF47
xref: uniprot P42229 45
organism: Homo sapiens

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P42227 43
organism: Mus musculus

uniprot F7BYN4 27
type: UnificationXref
id: F7BYN4
db: uniprot

Signal transducer and activator of transcription 4
type: ProteinReference
xref: PTHR11801:SF19
xref: uniprot P42228 44
organism: Mus musculus

Signal transducer and activator of transcription 1
type: ProteinReference
xref: uniprot P42225 40
xref: PTHR11801:SF18
organism: Mus musculus

uniprot Q1KQ07 54
type: UnificationXref
id: Q1KQ07
db: uniprot

uniprot F1MX38 19
type: UnificationXref
id: F1MX38
db: uniprot

Signal transducer and activator of transcription 6
type: ProteinReference
xref: uniprot P42226 42
xref: PTHR11801:SF48
organism: Homo sapiens

uniprot A0A1D5PR76 108
type: UnificationXref
id: A0A1D5PR76
db: uniprot

PARTICIPANT STOICHIOMETRY r35 180
type: Stoichiometry
physical entity: Cytokine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r35 181
type: Stoichiometry
physical entity: Complex (Cytokine Receptor/Cytokine)
stoichiometric coefficient: 1.0

ncbitaxon 10116 50
type: UnificationXref
id: 10116
db: ncbitaxon

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF19
xref: uniprot A0A1D5QTL2 10
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r42 159
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

ncbitaxon 9598 13
type: UnificationXref
id: 9598
db: ncbitaxon

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot Q6P943 57
xref: PTHR11801:SF18
organism: Danio rerio

uniprot Q14765 53
type: UnificationXref
id: Q14765
db: uniprot

uniprot O15524 76
type: UnificationXref
id: O15524
db: uniprot

uniprot F7CHH2 29
type: UnificationXref
id: F7CHH2
db: uniprot

uniprot E2RJ88 85
type: UnificationXref
id: E2RJ88
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

PTHR11801:SF19
type: RelationshipXref
id: PTHR11801:SF19
db: PANTHER Family
relationship type: By Homology

uniprot O75928 102
type: UnificationXref
id: O75928
db: uniprot

PTHR11801:SF18
type: RelationshipXref
id: PTHR11801:SF18
db: PANTHER Family
relationship type: By Homology

E3 SUMO-protein ligase PIAS4
type: ProteinReference
xref: uniprot Q9JM05 106
xref: PTHR10782:SF9
organism: Mus musculus

Y STAT s82 a137 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y STAT s82 a137 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.476222116492287
comment: MODIFICATION_RESIDUE_NAME=Y

Signal transducer and activator of transcription 5B
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot P51692 48
organism: Homo sapiens

STAT
type: Protein
entity reference: STAT
feature: S STAT s49 a73 rs2
feature: Y STAT s49 a73 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q68SP3 55
type: UnificationXref
id: Q68SP3
db: uniprot

uniprot F7GGH3 74
type: UnificationXref
id: F7GGH3
db: uniprot

Protein inhibitor of activated STAT 1
type: ProteinReference
xref: PTHR10782:SF11
xref: uniprot F7DN97 90
organism: Ornithorhynchus anatinus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot Q1KQ07 54
xref: PTHR11801:SF48
organism: Rattus norvegicus

S STAT s83 a138 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S STAT s83 a138 rs2 S
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.868219525848657

Uncharacterized protein
type: ProteinReference
xref: PTHR19134:SF284
xref: uniprot A0A1D5PR76 108
organism: Gallus gallus

STAT s83 a138 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Jak-RIGHT__Jak-_ADP-_r3
controller: Jak

PARTICIPANT STOICHIOMETRY r38 168
type: Stoichiometry
physical entity: Complex (Cytokine Receptor/Cytokine/ Jak)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r38 167
type: Stoichiometry
physical entity: 2 ATP
stoichiometric coefficient: 1.0

uniprot Q62689 133
type: UnificationXref
id: Q62689
db: uniprot

uniprot E1BEL4 115
type: UnificationXref
id: E1BEL4
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

ncbitaxon 9606 38
type: UnificationXref
id: 9606
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r38 169
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

Cytokine Receptor s7 sa6 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.811694274899256
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

ACTIVE 60
type: EntityFeature
comment: Active state

PIAS
type: ProteinReference
xref: P01031
standard name: Protein inhibitors of activated STATs
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=JAK/STAT signaling pathway.PROTEIN.GENERIC.PIAS
comment: ENTITY_REFERENCE_NOTES= Long Name: Protein inhibitors of activated STATs Synonym: PIAS Accession: P01031
member entity reference: Uncharacterized protein
member entity reference: E3 SUMO-protein ligase PIAS4
member entity reference: Protein inhibitor of-activated STAT 1
member entity reference: E3 SUMO-protein ligase PIAS1
member entity reference: Protein inhibitor of activated STAT 1 (Predicted)
member entity reference: E3 SUMO-protein ligase PIAS3
member entity reference: Pias4 protein
member entity reference: Protein inhibitor of activated STAT 2
member entity reference: Protein inhibitor of activated STAT 1
member entity reference: PIAS1 isoform 4
member entity reference: E3 SUMO-protein ligase PIAS2
member entity reference: PIAS3 isoform 4
member entity reference: PIAS2 isoform 1
member entity reference: PIAS3 protein
member entity reference: Protein inhibitor of activated STAT 3

PTHR11801:SF39
type: RelationshipXref
id: PTHR11801:SF39
db: PANTHER Family
relationship type: By Homology

STAT
type: Protein
entity reference: STAT
feature: ACTIVE 60
feature: Y STAT s41 a41 rs1
feature: S STAT s41 a41 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 28

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

PARTICIPANT STOICHIOMETRY r38 171
type: Stoichiometry
physical entity: 2 ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r38 170
type: Stoichiometry
physical entity: Complex (Cytokine Receptor/Cytokine/ STAT/Jak)
stoichiometric coefficient: 1.0

uniprot F1PNW8 21
type: UnificationXref
id: F1PNW8
db: uniprot

Cytokine Receptor s23 a43 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.811694274899256
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF2
xref: uniprot F1QWX8 120
organism: Danio rerio

Jak
type: ProteinReference
xref: P01034
comment: ENTITY_REFERENCE_NOTES= Long Name: Jak Synonym: Jak,Janus kinase,Tyk2 Accession: P01034
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=JAK/STAT signaling pathway.PROTEIN.GENERIC.Jak
member entity reference: Tyrosine-protein kinase
member entity reference: Tyrosine-protein kinase JAK1
member entity reference: Tyrosine-protein kinase JAK3
member entity reference: Tyrosine-protein kinase JAK2

PTHR11801:SF41
type: RelationshipXref
id: PTHR11801:SF41
db: PANTHER Family
relationship type: By Homology

ncbitaxon 10090 41
type: UnificationXref
id: 10090
db: ncbitaxon

PTHR11801:SF47
type: RelationshipXref
id: PTHR11801:SF47
db: PANTHER Family
relationship type: By Homology

uniprot P04157 110
type: UnificationXref
id: P04157
db: uniprot

Tyrosine-protein kinase JAK1
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot P52332 129
organism: Mus musculus

S STAT s82 a137 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S STAT s82 a137 rs2 S
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.868219525848657

Serine kinase
type: ProteinReference
xref: P01029
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=JAK/STAT signaling pathway.PROTEIN.GENERIC.Serine kinase
comment: ENTITY_REFERENCE_NOTES= Long Name: Serine kinase Synonym: Synonym not specified Accession: P01029
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 14A
member entity reference: Mitogen-activated protein kinase 14B

Tyrosine-protein kinase JAK3
type: ProteinReference
xref: uniprot P52333 130
xref: PTHR45807:SF3
organism: Homo sapiens

STAT
type: Complex
component stoichiometry: STAT s83 a138 STOICHIOMETRY ID COMPLEX
component: STAT
feature: ACTIVE 60
cellular location: nucleus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot Q68SP3 55
organism: Danio rerio

STAT
type: Complex
component stoichiometry: STAT s82 a137 STOICHIOMETRY ID COMPLEX
component: STAT
feature: ACTIVE 60
cellular location: cytoplasm

uniprot H2Q0U9 109
type: UnificationXref
id: H2Q0U9
db: uniprot

Y STAT s41 a41 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y STAT s41 a41 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.476222116492287
comment: MODIFICATION_RESIDUE_NAME=Y

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot O02812 66
organism: Canis lupus familiaris

uniprot A0A1D5QPR1 8
type: UnificationXref
id: A0A1D5QPR1
db: uniprot

Cytokine
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 145
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR11801:SF2
type: RelationshipXref
id: PTHR11801:SF2
db: PANTHER Family
relationship type: By Homology

2 ADP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

DISSOCIATION
type: InteractionVocabulary

GO GO:0005737 2
type: UnificationXref
id: GO:0005737
db: GO

STATE_TRANSITION_LEFT__STAT-RIGHT__Pi-_STAT-_r42
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 161
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 160
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 159
left: STAT
interaction type: STATE_TRANSITION
right: STAT
right: Pi

uniprot P42232 47
type: UnificationXref
id: P42232
db: uniprot

PIAS3 protein
type: ProteinReference
xref: PTHR10782:SF10
xref: uniprot A6QQU9 82
organism: Bos taurus

uniprot A0A2I3TNY5 12
type: UnificationXref
id: A0A2I3TNY5
db: uniprot

uniprot A0A1D5QTL2 10
type: UnificationXref
id: A0A1D5QTL2
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot F1MX38 19
organism: Bos taurus

uniprot F7HEF3 94
type: UnificationXref
id: F7HEF3
db: uniprot

Jak s6 sa5 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.87350024439705
comment: MODIFICATION_RESIDUE_NAME=

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot E2RB82 15
organism: Canis lupus familiaris

uniprot H9FNP4 96
type: UnificationXref
id: H9FNP4
db: uniprot

PIAS3 isoform 4
type: ProteinReference
xref: uniprot K7AQ66 97
xref: PTHR10782:SF10
organism: Pan troglodytes

ATP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTP
type: Protein
entity reference: PTP
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 38

Cytokine Receptor s1 sa1 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.811694274899256
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P47811 67
organism: Mus musculus

Receptor-type tyrosine-protein phosphatase C
type: ProteinReference
xref: PTHR19134:SF284
xref: uniprot P08575 111
organism: Homo sapiens

DISSOCIATION_LEFT__Complex__Cytokine_Receptor_Cytokine__STAT_Jak_-RIGHT__Complex__Cytokine_Receptor_Cytokine__Jak_-_STAT-_r39
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 166
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 164
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 165
left: Complex (Cytokine Receptor/Cytokine/ STAT/Jak)
interaction type: DISSOCIATION
right: STAT
right: Complex (Cytokine Receptor/Cytokine/ Jak)

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GFM9 93
xref: PTHR10782:SF12
organism: Macaca mulatta

uniprot F7GFM9 93
type: UnificationXref
id: F7GFM9
db: uniprot

uniprot O12990 126
type: UnificationXref
id: O12990
db: uniprot

PTHR10782:SF12
type: RelationshipXref
id: PTHR10782:SF12
db: PANTHER Family
relationship type: By Homology

uniprot P42229 45
type: UnificationXref
id: P42229
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Jak-RIGHT__Jak-_Pi-_r21
controller: PTP

PTHR10782:SF10
type: RelationshipXref
id: PTHR10782:SF10
db: PANTHER Family
relationship type: By Homology

PTHR10782:SF11
type: RelationshipXref
id: PTHR10782:SF11
db: PANTHER Family
relationship type: By Homology

uniprot P42226 42
type: UnificationXref
id: P42226
db: uniprot

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot Q6DV79 56
organism: Gallus gallus

uniprot P42224 39
type: UnificationXref
id: P42224
db: uniprot

Pias4 protein
type: ProteinReference
xref: uniprot B5DFF9 83
xref: PTHR10782:SF9
organism: Rattus norvegicus

P01034
type: UnificationXref
id: P01034
db: PANTHER Pathway Component

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P52631 49
organism: Rattus norvegicus

P01031
type: UnificationXref
id: P01031
db: PANTHER Pathway Component

PTHR19134:SF284
type: RelationshipXref
id: PTHR19134:SF284
db: PANTHER Family
relationship type: By Homology

Signal transducer and activator of transcription 5B
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot P52632 51
organism: Rattus norvegicus

P01030
type: UnificationXref
id: P01030
db: PANTHER Pathway Component

Signal transducer and transcription activator 6
type: ProteinReference
xref: uniprot P52633 52
xref: PTHR11801:SF48
organism: Mus musculus

Danio rerio
type: BioSource
xref: ncbitaxon 7955 36

Suppressor of cytokine signaling 1
type: ProteinReference
xref: uniprot F1MSN0 73
organism: Bos taurus

P01033
type: UnificationXref
id: P01033
db: PANTHER Pathway Component

P01027
type: UnificationXref
id: P01027
db: PANTHER Pathway Component

P01029
type: UnificationXref
id: P01029
db: PANTHER Pathway Component

Cytokine s5 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cytokine
stoichiometric coefficient: 1.0

uniprot Q6DV79 56
type: UnificationXref
id: Q6DV79
db: uniprot

uniprot Q62120 131
type: UnificationXref
id: Q62120
db: uniprot

uniprot O70260 100
type: UnificationXref
id: O70260
db: uniprot

Complex (Cytokine Receptor/Cytokine/ Jak)
type: Complex
component stoichiometry: Cytokine s5 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: Jak s6 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cytokine Receptor s3 sa3 STOICHIOMETRY ID COMPLEX
component: Cytokine Receptor
component: Jak
component: Cytokine
feature: COMPLEX BINDING FEATURE s77 a131 148
feature: COMPLEX BINDING FEATURE s77 a131 146
feature: COMPLEX BINDING FEATURE s77 a131 150
cellular location: cytoplasm

uniprot F1MGJ4 18
type: UnificationXref
id: F1MGJ4
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot F7BYN4 27
organism: Monodelphis domestica

Cytokine Receptor s3 sa3 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.811694274899256
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

STAT
type: Protein
entity reference: STAT
feature: ACTIVE 60
feature: Y STAT s83 a138 rs1
feature: S STAT s83 a138 rs2

Tyrosine-protein kinase JAK2
type: ProteinReference
xref: PTHR45807:SF1
xref: uniprot Q62120 131
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6V332 64
organism: Macaca mulatta

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__ATP-_Jak-RIGHT__Jak-_ADP-_r3
control type: INHIBITION
controller: SOCS

Complex (Cytokine Receptor/Cytokine/ STAT/Jak)
type: Complex
component stoichiometry: Cytokine Receptor s7 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cytokine s8 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: Jak s10 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: STAT s9 sa8 STOICHIOMETRY ID COMPLEX
component: Cytokine
component: Jak
component: Cytokine Receptor
component: STAT
feature: COMPLEX BINDING FEATURE s81 a136 140
feature: COMPLEX BINDING FEATURE s81 a136 136
feature: COMPLEX BINDING FEATURE s81 a136 138
feature: COMPLEX BINDING FEATURE s81 a136 134
cellular location: cytoplasm

uniprot H2QD19 33
type: UnificationXref
id: H2QD19
db: uniprot

uniprot H2PZ66 125
type: UnificationXref
id: H2PZ66
db: uniprot

PTHR10782:SF9
type: RelationshipXref
id: PTHR10782:SF9
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LTT9 63
organism: Bos taurus

uniprot Q9DGE2 72
type: UnificationXref
id: Q9DGE2
db: uniprot

Jak s18 a8 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.87350024439705
comment: MODIFICATION_RESIDUE_NAME=

uniprot A0A3Q1LTT9 63
type: UnificationXref
id: A0A3Q1LTT9
db: uniprot

PARTICIPANT STOICHIOMETRY r41 162
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r41 163
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot F7BQ11 25
type: UnificationXref
id: F7BQ11
db: uniprot

uniprot P42230 46
type: UnificationXref
id: P42230
db: uniprot

PIAS2 isoform 1
type: ProteinReference
xref: uniprot K7B8T0 98
xref: PTHR10782:SF12
organism: Pan troglodytes

Y STAT s83 a138 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y STAT s83 a138 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.476222116492287
comment: MODIFICATION_RESIDUE_NAME=Y

E3 SUMO-protein ligase PIAS3
type: ProteinReference
xref: uniprot H9FNP4 96
xref: PTHR10782:SF10
organism: Macaca mulatta

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot F7G8G5 32
organism: Macaca mulatta

uniprot K7D3K8 34
type: UnificationXref
id: K7D3K8
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot F6YLX1 122
organism: Macaca mulatta

Tyrosine-protein kinase JAK3
type: ProteinReference
xref: PTHR45807:SF3
xref: uniprot Q62137 132
organism: Mus musculus

uniprot F6YAB9 65
type: UnificationXref
id: F6YAB9
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A2I3TNY5 12
xref: PTHR11801:SF18
organism: Pan troglodytes

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 50

uniprot A0A2I3TQ88 14
type: UnificationXref
id: A0A2I3TQ88
db: uniprot

uniprot Q62137 132
type: UnificationXref
id: Q62137
db: uniprot

TRANSPORT_LEFT__STAT-RIGHT__STAT-_r41
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 162
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 163
left: STAT
interaction type: TRANSPORT
right: STAT

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

INHIBITION
type: RelationshipTypeVocabulary

Cytokine
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa7 137
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F6T2X3 22
type: UnificationXref
id: F6T2X3
db: uniprot

Pi
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=ION

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: STAT

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot E2RE22 17
xref: PTHR11801:SF47
organism: Canis lupus familiaris

uniprot O88907 103
type: UnificationXref
id: O88907
db: uniprot

ncbitaxon 13616 28
type: UnificationXref
id: 13616
db: ncbitaxon

Suppressor of cytokine signaling 1
type: ProteinReference
xref: uniprot O15524 76
organism: Homo sapiens

Jak s6 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Jak
stoichiometric coefficient: 1.0

Jak
type: Protein
entity reference: Jak
feature: ACTIVE 60
feature: Jak s10 sa9 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa9 141
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q95115 58
type: UnificationXref
id: Q95115
db: uniprot

Protein inhibitor of activated STAT 2
type: ProteinReference
xref: PTHR10782:SF12
xref: uniprot E2RJ88 85
organism: Canis lupus familiaris

uniprot P23458 128
type: UnificationXref
id: P23458
db: uniprot

uniprot A0A2I3SYV7 112
type: UnificationXref
id: A0A2I3SYV7
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

Cytokine s8 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cytokine
stoichiometric coefficient: 1.0

TRANSPORT
type: InteractionVocabulary

PTHR11801:SF48
type: RelationshipXref
id: PTHR11801:SF48
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot F1N0D6 117
organism: Bos taurus

E3 SUMO-protein ligase PIAS3
type: ProteinReference
xref: uniprot O54714 99
xref: PTHR10782:SF10
organism: Mus musculus

STAT
type: Protein
entity reference: STAT
feature: S STAT s21 a19 rs2
feature: Y STAT s21 a19 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F1PQ60 87
type: UnificationXref
id: F1PQ60
db: uniprot

GO GO:0005634 3
type: UnificationXref
id: GO:0005634
db: GO

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q16539 69
organism: Homo sapiens

uniprot Q6P943 57
type: UnificationXref
id: Q6P943
db: uniprot

Complex (Cytokine Receptor/Cytokine)
type: Complex
component stoichiometry: Cytokine Receptor s1 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cytokine s2 sa2 STOICHIOMETRY ID COMPLEX
component: Cytokine Receptor
component: Cytokine
feature: COMPLEX BINDING FEATURE s75 a126 144
feature: COMPLEX BINDING FEATURE s75 a126 142
cellular location: cytoplasm

HETERODIMER_ASSOCIATION_LEFT__Cytokine_Receptor-_Cytokine-RIGHT__Complex__Cytokine_Receptor_Cytokine_-_r35
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 181
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 180
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 179
left: Cytokine Receptor
left: Cytokine
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Cytokine Receptor/Cytokine)

uniprot P40763 37
type: UnificationXref
id: P40763
db: uniprot

uniprot G3V9W2 124
type: UnificationXref
id: G3V9W2
db: uniprot

E3 SUMO-protein ligase PIAS1
type: ProteinReference
xref: PTHR10782:SF11
xref: uniprot F7HEF3 94
organism: Macaca mulatta

uniprot E2R2U8 84
type: UnificationXref
id: E2R2U8
db: uniprot

Tyrosine-protein kinase JAK1
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot O12990 126
organism: Danio rerio

Signal transducer and activator of transcription 5A
type: ProteinReference
xref: uniprot Q95115 58
xref: PTHR11801:SF47
organism: Bos taurus

Protein inhibitor of activated STAT 1
type: ProteinReference
xref: PTHR10782:SF11
xref: uniprot A0A3Q1ML58 81
organism: Bos taurus

Cytokine Receptor
type: Protein
feature: Cytokine Receptor s1 sa1 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 143
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q16539 69
type: UnificationXref
id: Q16539
db: uniprot

uniprot F7CW94 30
type: UnificationXref
id: F7CW94
db: uniprot

uniprot Q8C5D8 105
type: UnificationXref
id: Q8C5D8
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E2RPW6 116
xref: PTHR45807:SF1
organism: Canis lupus familiaris

uniprot O75925 101
type: UnificationXref
id: O75925
db: uniprot

Suppressor of cytokine signaling 1
type: ProteinReference
xref: uniprot Q9QX78 78
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__STAT-RIGHT__STAT-_r40
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 172
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 173
left: STAT
interaction type: STATE_TRANSITION
right: STAT

STAT
type: Protein
entity reference: STAT
feature: ACTIVE 60
feature: Y STAT s82 a137 rs1
feature: S STAT s82 a137 rs2

uniprot E1BCP6 114
type: UnificationXref
id: E1BCP6
db: uniprot

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

STATE_TRANSITION_LEFT__Jak-RIGHT__Jak-_Pi-_r21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 158
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 157
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 156
left: Jak
interaction type: STATE_TRANSITION
right: Pi
right: Jak

PTPRC isoform 2
type: ProteinReference
xref: PTHR19134:SF284
xref: uniprot H2Q0U9 109
organism: Pan troglodytes

cytoplasm
type: CellularLocationVocabulary
xref: GO GO:0005737 2

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F6UMM2 24
xref: PTHR11801:SF48
organism: Macaca mulatta

uniprot F1PAY3 20
type: UnificationXref
id: F1PAY3
db: uniprot

uniprot A6QQU9 82
type: UnificationXref
id: A6QQU9
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF48
xref: uniprot F1MGJ4 18
organism: Bos taurus