2-isopropylmalate synthase
type: ProteinReference
xref: uniprot O59736 4
organism: Schizosaccharomyces pombe

uniprot A0A1D5Q6Y3 36
type: UnificationXref
id: A0A1D5Q6Y3
db: uniprot

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot F1PY28 44
organism: Canis lupus familiaris

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 83

uniprot P94568 129
type: UnificationXref
id: P94568
db: uniprot

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot A0A2I3RE03 38
organism: Pan troglodytes

uniprot Q9XXD8 91
type: UnificationXref
id: Q9XXD8
db: uniprot

ncbitaxon 9544 37
type: UnificationXref
id: 9544
db: ncbitaxon

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 14

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot A0A3Q1ML78 40
organism: Bos taurus

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 78

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9HZA3 137
type: UnificationXref
id: Q9HZA3
db: uniprot

uniprot P38891 60
type: UnificationXref
id: P38891
db: uniprot

Methionine aminotransferase BCAT4
type: ProteinReference
xref: uniprot Q9LE06 84
organism: Arabidopsis thaliana

uniprot O67862 6
type: UnificationXref
id: O67862
db: uniprot

3-isopropylmalate dehydrogenase 1, chloroplastic
type: ProteinReference
xref: uniprot Q9FMT1 112
organism: Arabidopsis thaliana

uniprot Q8ZW34 111
type: UnificationXref
id: Q8ZW34
db: uniprot

Methylthioalkylmalate synthase 3, chloroplastic
type: ProteinReference
xref: uniprot Q9FN52 31
organism: Arabidopsis thaliana

uniprot O35855 53
type: UnificationXref
id: O35855
db: uniprot

uniprot Q9HZA4 138
type: UnificationXref
id: Q9HZA4
db: uniprot

uniprot Q9FMT1 112
type: UnificationXref
id: Q9FMT1
db: uniprot

uniprot O59736 4
type: UnificationXref
id: O59736
db: uniprot

uniprot P81291 128
type: UnificationXref
id: P81291
db: uniprot

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot P04173 98
organism: Saccharomyces cerevisiae

CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

3-isopropylmalate/3-methylmalate dehydrogenase
type: ProteinReference
xref: uniprot Q58130 108
organism: Methanocaldococcus jannaschii

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 35

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Acetyl_CoA-_2_keto_isovalerate-_H2O-RIGHT__3_carboxy_3_hydroxy_isocaproate-_CoA-_r1
controller: 2-Isopropylmalate synthase

ncbitaxon 237631 125
type: UnificationXref
id: 237631
db: ncbitaxon

3-isopropylmalate dehydratase
type: ProteinReference
xref: uniprot P07264 120
organism: Saccharomyces cerevisiae

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q9XXD8 91
organism: Caenorhabditis elegans

uniprot O60027 94
type: UnificationXref
id: O60027
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 54

ncbitaxon 83332 70
type: UnificationXref
id: 83332
db: ncbitaxon

uniprot O86534 118
type: UnificationXref
id: O86534
db: uniprot

Branched-chain-amino-acid transaminase 1
type: ProteinReference
xref: uniprot O31461 50
organism: Bacillus subtilis

uniprot Q12166 12
type: UnificationXref
id: Q12166
db: uniprot

Putative branched-chain-amino-acid aminotransferase 7
type: ProteinReference
xref: uniprot Q9LPM8 85
organism: Arabidopsis thaliana

Branched-chain-amino-acid aminotransferase 6
type: ProteinReference
xref: uniprot Q9LPM9 86
organism: Arabidopsis thaliana

uniprot O86535 119
type: UnificationXref
id: O86535
db: uniprot

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot O66607 96
organism: Aquifex aeolicus

ncbitaxon 284811 95
type: UnificationXref
id: 284811
db: ncbitaxon

2-isopropylmalate synthase
type: ProteinReference
xref: uniprot Q9RUA9 32
organism: Deinococcus radiodurans

uniprot Q8TLF1 134
type: UnificationXref
id: Q8TLF1
db: uniprot

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q7QEI9 77
organism: Anopheles gambiae

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 9

Isopropylmalate/citramalate isomerase large subunit
type: ProteinReference
xref: uniprot P81291 128
organism: Methanocaldococcus jannaschii

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 68

CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Branched-chain-amino-acid aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot O35855 53
organism: Mus musculus

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot P73960 105
organism: Synechocystis

Yarrowia lipolytica
type: BioSource
xref: ncbitaxon 284591 101

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 90

uniprot Q8A6L9 21
type: UnificationXref
id: Q8A6L9
db: uniprot

Probable branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot O67733 55
organism: Aquifex aeolicus

3-isopropylmalate dehydratase large subunit
type: ProteinReference
xref: uniprot P54384 126
organism: Synechocystis

ncbitaxon 6238 43
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot Q58409 132
type: UnificationXref
id: Q58409
db: uniprot

ncbitaxon 100226 3
type: UnificationXref
id: 100226
db: ncbitaxon

ncbitaxon 208964 57
type: UnificationXref
id: 208964
db: ncbitaxon

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot F5HCK8 92
organism: Phaeosphaeria nodorum

PARTICIPANT STOICHIOMETRY re6 154
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Branched-chain-amino-acid aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot Q5EA40 74
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re6 156
type: Stoichiometry
physical entity: CO2
stoichiometric coefficient: 1.0

3-carboxy-3-hydroxy-isocaproate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re6 155
type: Stoichiometry
physical entity: 2-threo-hydroxy-3-carboxy-isocaproate
stoichiometric coefficient: 1.0

uniprot P04173 98
type: UnificationXref
id: P04173
db: uniprot

PARTICIPANT STOICHIOMETRY re6 157
type: Stoichiometry
physical entity: 2-keto-4-methyl-pentanoate
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NAD-_2_threo_hydroxy_3_carboxy_isocaproate-RIGHT__CO2-_2_keto_4_methyl_pentanoate-_NADH-_re6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 155
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 157
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 156
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 158
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 154
left: 2-threo-hydroxy-3-carboxy-isocaproate
left: NAD
interaction type: STATE_TRANSITION
right: 2-keto-4-methyl-pentanoate
right: CO2
right: NADH

PARTICIPANT STOICHIOMETRY re6 158
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

uniprot O15382 48
type: UnificationXref
id: O15382
db: uniprot

P03001
type: UnificationXref
id: P03001
db: PANTHER Pathway Component

uniprot A8WM75 42
type: UnificationXref
id: A8WM75
db: uniprot

uniprot Q9LPM9 86
type: UnificationXref
id: Q9LPM9
db: uniprot

P03002
type: UnificationXref
id: P03002
db: PANTHER Pathway Component

uniprot Q8TJJ1 27
type: UnificationXref
id: Q8TJJ1
db: uniprot

P03000
type: UnificationXref
id: P03000
db: PANTHER Pathway Component

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 16

ncbitaxon 9913 41
type: UnificationXref
id: 9913
db: ncbitaxon

ncbitaxon 226186 20
type: UnificationXref
id: 226186
db: ncbitaxon

3-isopropylmalate dehydratase large subunit
type: ProteinReference
xref: uniprot O67078 117
organism: Aquifex aeolicus

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 20

2-keto-isovalerate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

2-isopropylmalate synthase
type: ProteinReference
xref: uniprot Q7UI51 17
organism: Rhodopirellula baltica

PARTICIPANT STOICHIOMETRY r1 145
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

uniprot Q7QEI9 77
type: UnificationXref
id: Q7QEI9
db: uniprot

PARTICIPANT STOICHIOMETRY r1 147
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 146
type: Stoichiometry
physical entity: 2-keto-isovalerate
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Acetyl_CoA-_2_keto_isovalerate-_H2O-RIGHT__3_carboxy_3_hydroxy_isocaproate-_CoA-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 146
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 147
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 149
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 148
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 145
left: 2-keto-isovalerate
left: H2O
left: Acetyl-CoA
interaction type: STATE_TRANSITION
right: CoA
right: 3-carboxy-3-hydroxy-isocaproate

PANTHER Pathway P02749 1
type: UnificationXref
id: P02749
db: PANTHER Pathway

PARTICIPANT STOICHIOMETRY r1 149
type: Stoichiometry
physical entity: CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 148
type: Stoichiometry
physical entity: 3-carboxy-3-hydroxy-isocaproate
stoichiometric coefficient: 1.0

Branched-chain-amino-acid aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot O35854 51
organism: Rattus norvegicus

uniprot O67078 117
type: UnificationXref
id: O67078
db: uniprot

uniprot O86505 58
type: UnificationXref
id: O86505
db: uniprot

uniprot P54690 66
type: UnificationXref
id: P54690
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 5

uniprot Q8THA5 24
type: UnificationXref
id: Q8THA5
db: uniprot

Ashbya gossypii
type: BioSource
xref: ncbitaxon 284811 95

3-isopropylmalate dehydratase large subunit 1
type: ProteinReference
xref: uniprot Q9WYC7 141
organism: Thermotoga maritima

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot H2QGS7 47
organism: Pan troglodytes

ncbitaxon 559292 9
type: UnificationXref
id: 559292
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__3_carboxy_3_hydroxy_isocaproate-RIGHT__2_threo_hydroxy_3_carboxy_isocaproate-_re5
controller: Isopropylmalate isomerase

3-isopropylmalate dehydratase large subunit
type: ProteinReference
xref: uniprot P9WQF5 131
organism: Mycobacterium tuberculosis

uniprot P05645 99
type: UnificationXref
id: P05645
db: uniprot

uniprot Q9WZ24 142
type: UnificationXref
id: Q9WZ24
db: uniprot

ncbitaxon 3702 30
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot Q9FG67 29
type: UnificationXref
id: Q9FG67
db: uniprot

uniprot Q8TKQ6 28
type: UnificationXref
id: Q8TKQ6
db: uniprot

ncbitaxon 188937 25
type: UnificationXref
id: 188937
db: ncbitaxon

3-isopropylmalate dehydratase large subunit 2
type: ProteinReference
xref: uniprot Q9RTI6 139
organism: Deinococcus radiodurans

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot O86428 56
organism: Pseudomonas aeruginosa

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 39

PARTICIPANT STOICHIOMETRY re7 153
type: Stoichiometry
physical entity: leucine
stoichiometric coefficient: 1.0

uniprot Q8A6L6 19
type: UnificationXref
id: Q8A6L6
db: uniprot

PARTICIPANT STOICHIOMETRY re7 152
type: Stoichiometry
physical entity: 2-ketoglutarate
stoichiometric coefficient: 1.0

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot Q51375 107
organism: Pseudomonas aeruginosa

PARTICIPANT STOICHIOMETRY re7 151
type: Stoichiometry
physical entity: 2-keto-4-methyl-pentanoate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 150
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

uniprot O67733 55
type: UnificationXref
id: O67733
db: uniprot

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot P9WQ75 69
organism: Mycobacterium tuberculosis

uniprot P18869 102
type: UnificationXref
id: P18869
db: uniprot

Branched chain amino acid aminotransferase
type: Protein
entity reference: Branched chain amino acid aminotransferase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 243232 73
type: UnificationXref
id: 243232
db: ncbitaxon

ncbitaxon 178306 81
type: UnificationXref
id: 178306
db: ncbitaxon

uniprot Q9WZ26 115
type: UnificationXref
id: Q9WZ26
db: uniprot

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q1K779 71
organism: Neurospora crassa

uniprot P80858 127
type: UnificationXref
id: P80858
db: uniprot

3-isopropylmalate dehydratase
type: ProteinReference
xref: uniprot O14289 116
organism: Schizosaccharomyces pombe

3-isopropylmalate dehydratase small subunit
type: ProteinReference
xref: uniprot P94568 129
organism: Bacillus subtilis

uniprot Q8TI08 79
type: UnificationXref
id: Q8TI08
db: uniprot

2-isopropylmalate synthase
type: ProteinReference
xref: uniprot P94565 10
organism: Bacillus subtilis

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q9VYD5 89
organism: Drosophila melanogaster

Branched-chain-amino-acid aminotransferase 2
type: ProteinReference
xref: uniprot P39576 61
organism: Bacillus subtilis

Putative (R)-citramalate synthase CimA
type: ProteinReference
xref: uniprot Q8TJJ1 27
organism: Methanosarcina acetivorans

uniprot Q7NNJ0 13
type: UnificationXref
id: Q7NNJ0
db: uniprot

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 23

uniprot P54687 63
type: UnificationXref
id: P54687
db: uniprot

uniprot Q9RTY9 140
type: UnificationXref
id: Q9RTY9
db: uniprot

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot Q9RTH9 113
organism: Deinococcus radiodurans

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 33

uniprot Q9FN52 31
type: UnificationXref
id: Q9FN52
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 49

uniprot Q9RTI6 139
type: UnificationXref
id: Q9RTI6
db: uniprot

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 73

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot A0A1D5Q6Y3 36
organism: Macaca mulatta

glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot O60027 94
organism: Ashbya gossypii

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 30

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q9RTX5 88
organism: Deinococcus radiodurans

2-isopropylmalate synthase
type: ProteinReference
xref: uniprot Q7SFM2 15
organism: Neurospora crassa

Probable methanogen homoaconitase large subunit
type: ProteinReference
xref: uniprot Q8TLF1 134
organism: Methanosarcina acetivorans

uniprot F1PY28 44
type: UnificationXref
id: F1PY28
db: uniprot

Isopropylmalate isomerase
type: ProteinReference
xref: P03002
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Leucine biosynthesis.PROTEIN.GENERIC.Isopropylmalate_br_isomerase
comment: ENTITY_REFERENCE_NOTES= Long Name: Isopropylmalate isomerase Synonym: Synonym not specified Accession: P03002
member entity reference: 3-isopropylmalate dehydratase large subunit
member entity reference: Isopropylmalate/citramalate isomerase large subunit
member entity reference: Probable methanogen homoaconitase large subunit
member entity reference: 3-isopropylmalate dehydratase
member entity reference: 3-isopropylmalate dehydratase small subunit
member entity reference: 3-isopropylmalate dehydratase large subunit 1
member entity reference: Methanogen homoaconitase large subunit
member entity reference: 3-isopropylmalate dehydratase large subunit 2
member entity reference: Probable 3-isopropylmalate dehydratase large subunit

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q9HNF8 82
organism: Halobacterium salinarum

3-isopropylmalate dehydratase large subunit
type: ProteinReference
xref: uniprot P80858 127
organism: Bacillus subtilis

uniprot P39576 61
type: UnificationXref
id: P39576
db: uniprot

ncbitaxon 367110 16
type: UnificationXref
id: 367110
db: ncbitaxon

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 70

2-isopropylmalate synthase
type: ProteinReference
xref: uniprot P06208 8
organism: Saccharomyces cerevisiae

uniprot Q8TI92 26
type: UnificationXref
id: Q8TI92
db: uniprot

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 122

3-isopropylmalate dehydratase large subunit 1
type: ProteinReference
xref: uniprot Q9RTY9 140
organism: Deinococcus radiodurans

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot F6ZG49 46
organism: Macaca mulatta

Branched-chain-amino-acid aminotransferase 3, chloroplastic
type: ProteinReference
xref: uniprot Q9M401 87
organism: Arabidopsis thaliana

Leucine biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__3_carboxy_3_hydroxy_isocaproate-RIGHT__2_threo_hydroxy_3_carboxy_isocaproate-_re5
pathway component: STATE_TRANSITION_LEFT__glutamate-_2_keto_4_methyl_pentanoate-RIGHT__2_ketoglutarate-_leucine-_re7
pathway component: STATE_TRANSITION_LEFT__NAD-_2_threo_hydroxy_3_carboxy_isocaproate-RIGHT__CO2-_2_keto_4_methyl_pentanoate-_NADH-_re6
pathway component: STATE_TRANSITION_LEFT__Acetyl_CoA-_2_keto_isovalerate-_H2O-RIGHT__3_carboxy_3_hydroxy_isocaproate-_CoA-_r1
xref: PANTHER Pathway P02749 1
comment: MODEL_NOTES= The biosynthesis of the amino acid leucine critical to protein synthesis. Website=www.biocyc.org/Ecoli/Pathway/ free text=Biochemistry (text) Voet and Voet

uniprot Q7SFM2 15
type: UnificationXref
id: Q7SFM2
db: uniprot

uniprot Q7UI51 17
type: UnificationXref
id: Q7UI51
db: uniprot

uniprot O86428 56
type: UnificationXref
id: O86428
db: uniprot

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q8ZTE2 80
organism: Pyrobaculum aerophilum

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot P18869 102
organism: Schizosaccharomyces pombe

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot P05645 99
organism: Bacillus subtilis

ncbitaxon 83333 122
type: UnificationXref
id: 83333
db: ncbitaxon

3-isopropylmalate dehydratase small subunit
type: ProteinReference
xref: uniprot P30126 123
organism: Escherichia coli

uniprot O86504 97
type: UnificationXref
id: O86504
db: uniprot

2-isopropylmalate synthase
type: ProteinReference
xref: uniprot Q8F445 22
organism: Leptospira interrogans

3-isopropylmalate dehydratase small subunit
type: ProteinReference
xref: uniprot P9WK95 130
organism: Mycobacterium tuberculosis

uniprot P24015 103
type: UnificationXref
id: P24015
db: uniprot

Branched-chain-amino-acid aminotransferase, cytosolic
type: ProteinReference
xref: uniprot P54690 66
organism: Rattus norvegicus

uniprot Q9LPM8 85
type: UnificationXref
id: Q9LPM8
db: uniprot

uniprot P73960 105
type: UnificationXref
id: P73960
db: uniprot

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot P34738 104
organism: Neurospora crassa

Probable branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot P54691 67
organism: Synechocystis

ncbitaxon 64091 83
type: UnificationXref
id: 64091
db: ncbitaxon

Isopropylmalate isomerase
type: Protein
entity reference: Isopropylmalate isomerase
comment: SPECIES_TYPE=PROTEIN

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 125

Branched-chain-amino-acid aminotransferase, cytosolic
type: ProteinReference
xref: uniprot P54688 64
organism: Caenorhabditis elegans

ncbitaxon 9598 39
type: UnificationXref
id: 9598
db: ncbitaxon

STATE_TRANSITION_LEFT__glutamate-_2_keto_4_methyl_pentanoate-RIGHT__2_ketoglutarate-_leucine-_re7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 151
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 153
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 152
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 150
left: 2-keto-4-methyl-pentanoate
left: glutamate
interaction type: STATE_TRANSITION
right: leucine
right: 2-ketoglutarate

P02999
type: UnificationXref
id: P02999
db: PANTHER Pathway Component

uniprot Q9RTH9 113
type: UnificationXref
id: Q9RTH9
db: uniprot

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot P18120 100
organism: Yarrowia lipolytica

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__glutamate-_2_keto_4_methyl_pentanoate-RIGHT__2_ketoglutarate-_leucine-_re7
controller: Branched chain amino acid aminotransferase

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot P24015 103
organism: Leptospira interrogans

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 11

uniprot Q6CG29 133
type: UnificationXref
id: Q6CG29
db: uniprot

3-isopropylmalate dehydratase large subunit
type: ProteinReference
xref: uniprot Q8ZW41 136
organism: Pyrobaculum aerophilum

ncbitaxon 1111708 68
type: UnificationXref
id: 1111708
db: ncbitaxon

Bos taurus
type: BioSource
xref: ncbitaxon 9913 41

uniprot A0A2I3RE03 38
type: UnificationXref
id: A0A2I3RE03
db: uniprot

2-ketoglutarate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Branched-chain-amino-acid aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot O15382 48
organism: Homo sapiens

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 37

ncbitaxon 7165 78
type: UnificationXref
id: 7165
db: ncbitaxon

Probable branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot O86505 58
organism: Streptomyces coelicolor

uniprot Q9SA14 114
type: UnificationXref
id: Q9SA14
db: uniprot

uniprot O35854 51
type: UnificationXref
id: O35854
db: uniprot

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot O86504 97
organism: Streptomyces coelicolor

Branched-chain-amino-acid aminotransferase, cytosolic
type: ProteinReference
xref: uniprot P47176 62
organism: Saccharomyces cerevisiae

uniprot Q9M401 87
type: UnificationXref
id: Q9M401
db: uniprot

Isopropylmalate/homocitrate/citramalate synthase family protein
type: ProteinReference
xref: uniprot Q8TI92 26
organism: Methanosarcina acetivorans

uniprot Q58130 108
type: UnificationXref
id: Q58130
db: uniprot

2-Isopropylmalate synthase
type: Protein
entity reference: 2-Isopropylmalate synthase
comment: SPECIES_TYPE=PROTEIN

Putative homocitrate synthase AksA
type: ProteinReference
xref: uniprot Q8TKQ6 28
organism: Methanosarcina acetivorans

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot P9WKK9 106
organism: Mycobacterium tuberculosis

uniprot Q8TQZ3 135
type: UnificationXref
id: Q8TQZ3
db: uniprot

ncbitaxon 9606 49
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot Q6AT43 75
type: UnificationXref
id: Q6AT43
db: uniprot

uniprot P0A6A6 121
type: UnificationXref
id: P0A6A6
db: uniprot

3-isopropylmalate dehydratase large subunit
type: ProteinReference
xref: uniprot P0A6A6 121
organism: Escherichia coli

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot Q9WZ26 115
organism: Thermotoga maritima

ncbitaxon 321614 93
type: UnificationXref
id: 321614
db: ncbitaxon

3-isopropylmalate dehydrogenase (LeuB)
type: ProteinReference
xref: uniprot Q8ZW34 111
organism: Pyrobaculum aerophilum

uniprot O31461 50
type: UnificationXref
id: O31461
db: uniprot

2-isopropylmalate synthase
type: ProteinReference
xref: uniprot Q9WZ23 34
organism: Thermotoga maritima

uniprot P07264 120
type: UnificationXref
id: P07264
db: uniprot

3-isopropylmalate dehydratase large subunit 2
type: ProteinReference
xref: uniprot Q9WZ24 142
organism: Thermotoga maritima

3-isopropylmalate dehydratase
type: ProteinReference
xref: uniprot Q6CG29 133
organism: Yarrowia lipolytica

3-isopropylmalate dehydratase large subunit
type: ProteinReference
xref: uniprot O86534 118
organism: Streptomyces coelicolor

2-Isopropylmalate synthase
type: ProteinReference
xref: P02999
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Leucine biosynthesis.PROTEIN.GENERIC.2-Isopropylmalate_br_synthase
comment: ENTITY_REFERENCE_NOTES= Long Name: 2-Isopropylmalate synthase Synonym: Synonym not specified Accession: P02999
member entity reference: Methylthioalkylmalate synthase 3, chloroplastic
member entity reference: 2-isopropylmalate synthase
member entity reference: 2-isopropylmalate synthase 2, mitochondrial
member entity reference: Putative homocitrate synthase AksA
member entity reference: Isopropylmalate/homocitrate/citramalate synthase family protein
member entity reference: Putative (R)-citramalate synthase CimA
member entity reference: Probable 2-isopropylmalate synthase
member entity reference: Methylthioalkylmalate synthase 1, chloroplastic

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 25

3-isopropylmalate dehydratase small subunit
type: ProteinReference
xref: uniprot O86535 119
organism: Streptomyces coelicolor

ncbitaxon 224324 7
type: UnificationXref
id: 224324
db: ncbitaxon

ncbitaxon 6239 65
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot Q9VYD5 89
type: UnificationXref
id: Q9VYD5
db: uniprot

uniprot P9WQF5 131
type: UnificationXref
id: P9WQF5
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 52

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 7

uniprot P47176 62
type: UnificationXref
id: P47176
db: uniprot

2-threo-hydroxy-3-carboxy-isocaproate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 45

uniprot P34738 104
type: UnificationXref
id: P34738
db: uniprot

3-isopropylmalate dehydrogenase 3, chloroplastic
type: ProteinReference
xref: uniprot Q9SA14 114
organism: Arabidopsis thaliana

Branched-chain-amino-acid aminotransferase, cytosolic
type: ProteinReference
xref: uniprot P54687 63
organism: Homo sapiens

uniprot P9WKK9 106
type: UnificationXref
id: P9WKK9
db: uniprot

uniprot P06208 8
type: UnificationXref
id: P06208
db: uniprot

uniprot O14289 116
type: UnificationXref
id: O14289
db: uniprot

uniprot Q9RTX5 88
type: UnificationXref
id: Q9RTX5
db: uniprot

uniprot Q8ZW41 136
type: UnificationXref
id: Q8ZW41
db: uniprot

NADH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P54691 67
type: UnificationXref
id: P54691
db: uniprot

ncbitaxon 39947 76
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot Q58414 72
type: UnificationXref
id: Q58414
db: uniprot

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 81

Branched chain amino acid aminotransferase
type: ProteinReference
xref: P03000
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Branched chain amino acid aminotransferase Synonym: Synonym not specified Accession: P03000
comment: ENTITY_REFERENCE_ID_DESC=Leucine biosynthesis.PROTEIN.GENERIC.Branched chain_br_amino acid_br_aminotransferase
member entity reference: Branched-chain-amino-acid aminotransferase, mitochondrial
member entity reference: Branched-chain-amino-acid aminotransferase, cytosolic
member entity reference: Branched-chain-amino-acid aminotransferase
member entity reference: Methionine aminotransferase BCAT4
member entity reference: Branched-chain-amino-acid aminotransferase 6
member entity reference: Branched-chain-amino-acid transaminase 1
member entity reference: Probable branched-chain-amino-acid aminotransferase
member entity reference: Branched-chain-amino-acid aminotransferase 3, chloroplastic
member entity reference: Branched-chain-amino-acid aminotransferase 2
member entity reference: Putative branched-chain-amino-acid aminotransferase 7
member entity reference: Putative branched-chain-amino-acid aminotransferase

uniprot Q9HNF8 82
type: UnificationXref
id: Q9HNF8
db: uniprot

2-isopropylmalate synthase
type: ProteinReference
xref: uniprot Q7NNJ0 13
organism: Gloeobacter violaceus

3-Isopropylmalate dehydrogenase
type: ProteinReference
xref: P03001
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: 3-Isopropylmalate dehydrogenase Synonym: Synonym not specified Accession: P03001
comment: ENTITY_REFERENCE_ID_DESC=Leucine biosynthesis.PROTEIN.GENERIC.3-Isopropylmalate_br_dehydrogenase
member entity reference: 3-isopropylmalate dehydrogenase
member entity reference: 3-isopropylmalate dehydrogenase (LeuB)
member entity reference: 3-isopropylmalate dehydrogenase 1, chloroplastic
member entity reference: 3-isopropylmalate dehydrogenase 3, chloroplastic
member entity reference: 3-isopropylmalate/3-methylmalate dehydrogenase

uniprot Q8A6M0 109
type: UnificationXref
id: Q8A6M0
db: uniprot

Putative branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q58414 72
organism: Methanocaldococcus jannaschii

ncbitaxon 243274 35
type: UnificationXref
id: 243274
db: ncbitaxon

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 18

uniprot P24288 59
type: UnificationXref
id: P24288
db: uniprot

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 3

2-isopropylmalate synthase
type: ProteinReference
xref: uniprot Q8A6L6 19
organism: Bacteroides thetaiotaomicron

Acetyl-CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

3-Isopropylmalate dehydrogenase
type: Protein
entity reference: 3-Isopropylmalate dehydrogenase
comment: SPECIES_TYPE=PROTEIN

uniprot Q5EA40 74
type: UnificationXref
id: Q5EA40
db: uniprot

Methanogen homoaconitase large subunit
type: ProteinReference
xref: uniprot Q58409 132
organism: Methanocaldococcus jannaschii

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

2-keto-4-methyl-pentanoate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Probable 2-isopropylmalate synthase
type: ProteinReference
xref: uniprot Q8THA5 24
organism: Methanosarcina acetivorans

STATE_TRANSITION_LEFT__3_carboxy_3_hydroxy_isocaproate-RIGHT__2_threo_hydroxy_3_carboxy_isocaproate-_re5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 143
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 144
left: 3-carboxy-3-hydroxy-isocaproate
interaction type: STATE_TRANSITION
right: 2-threo-hydroxy-3-carboxy-isocaproate

Methylthioalkylmalate synthase 1, chloroplastic
type: ProteinReference
xref: uniprot Q9FG67 29
organism: Arabidopsis thaliana

uniprot F6ZG49 46
type: UnificationXref
id: F6ZG49
db: uniprot

uniprot Q9WYC7 141
type: UnificationXref
id: Q9WYC7
db: uniprot

ncbitaxon 9615 45
type: UnificationXref
id: 9615
db: ncbitaxon

2-isopropylmalate synthase 2, mitochondrial
type: ProteinReference
xref: uniprot Q12166 12
organism: Saccharomyces cerevisiae

uniprot H2QGS7 47
type: UnificationXref
id: H2QGS7
db: uniprot

ncbitaxon 284812 5
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot Q9LE06 84
type: UnificationXref
id: Q9LE06
db: uniprot

uniprot P54688 64
type: UnificationXref
id: P54688
db: uniprot

3-isopropylmalate dehydratase large subunit
type: ProteinReference
xref: uniprot Q9HZA3 137
organism: Pseudomonas aeruginosa

uniprot P54384 126
type: UnificationXref
id: P54384
db: uniprot

3-isopropylmalate dehydratase small subunit
type: ProteinReference
xref: uniprot Q9HZA4 138
organism: Pseudomonas aeruginosa

2-isopropylmalate synthase
type: ProteinReference
xref: uniprot Q8A6L9 21
organism: Bacteroides thetaiotaomicron

uniprot Q8TU72 110
type: UnificationXref
id: Q8TU72
db: uniprot

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot Q8A6M0 109
organism: Bacteroides thetaiotaomicron

PARTICIPANT STOICHIOMETRY re5 143
type: Stoichiometry
physical entity: 3-carboxy-3-hydroxy-isocaproate
stoichiometric coefficient: 1.0

ncbitaxon 243230 33
type: UnificationXref
id: 243230
db: ncbitaxon

ncbitaxon 251221 14
type: UnificationXref
id: 251221
db: ncbitaxon

ncbitaxon 243090 18
type: UnificationXref
id: 243090
db: ncbitaxon

uniprot Q8ZTE2 80
type: UnificationXref
id: Q8ZTE2
db: uniprot

PARTICIPANT STOICHIOMETRY re5 144
type: Stoichiometry
physical entity: 2-threo-hydroxy-3-carboxy-isocaproate
stoichiometric coefficient: 1.0

ncbitaxon 10090 54
type: UnificationXref
id: 10090
db: ncbitaxon

ncbitaxon 10116 52
type: UnificationXref
id: 10116
db: ncbitaxon

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot A8WM75 42
organism: Caenorhabditis briggsae

uniprot Q9RUA9 32
type: UnificationXref
id: Q9RUA9
db: uniprot

uniprot Q1K779 71
type: UnificationXref
id: Q1K779
db: uniprot

ncbitaxon 284591 101
type: UnificationXref
id: 284591
db: ncbitaxon

ncbitaxon 189518 23
type: UnificationXref
id: 189518
db: ncbitaxon

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q8TI08 79
organism: Methanosarcina acetivorans

uniprot P18120 100
type: UnificationXref
id: P18120
db: uniprot

Probable 3-isopropylmalate dehydratase large subunit
type: ProteinReference
xref: uniprot Q8TQZ3 135
organism: Methanosarcina acetivorans

Branched-chain-amino-acid aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot P38891 60
organism: Saccharomyces cerevisiae

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 43

Branched-chain-amino-acid aminotransferase, cytosolic
type: ProteinReference
xref: uniprot P24288 59
organism: Mus musculus

3-isopropylmalate dehydratase
type: ProteinReference
xref: uniprot P49601 124
organism: Ustilago maydis

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 65

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 93

uniprot F5HCK8 92
type: UnificationXref
id: F5HCK8
db: uniprot

uniprot Q8F445 22
type: UnificationXref
id: Q8F445
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NAD-_2_threo_hydroxy_3_carboxy_isocaproate-RIGHT__CO2-_2_keto_4_methyl_pentanoate-_NADH-_re6
controller: 3-Isopropylmalate dehydrogenase

leucine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

2-isopropylmalate synthase
type: ProteinReference
xref: uniprot O31046 2
organism: Streptomyces coelicolor

uniprot O31046 2
type: UnificationXref
id: O31046
db: uniprot

uniprot Q51375 107
type: UnificationXref
id: Q51375
db: uniprot

uniprot O66607 96
type: UnificationXref
id: O66607
db: uniprot

ncbitaxon 224308 11
type: UnificationXref
id: 224308
db: ncbitaxon

uniprot P49601 124
type: UnificationXref
id: P49601
db: uniprot

2-isopropylmalate synthase
type: ProteinReference
xref: uniprot O67862 6
organism: Aquifex aeolicus

uniprot P9WQ75 69
type: UnificationXref
id: P9WQ75
db: uniprot

uniprot A0A3Q1ML78 40
type: UnificationXref
id: A0A3Q1ML78
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 76

3-isopropylmalate dehydrogenase
type: ProteinReference
xref: uniprot Q8TU72 110
organism: Methanosarcina acetivorans

uniprot P9WK95 130
type: UnificationXref
id: P9WK95
db: uniprot

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 57

uniprot P94565 10
type: UnificationXref
id: P94565
db: uniprot

uniprot Q9WZ23 34
type: UnificationXref
id: Q9WZ23
db: uniprot

ncbitaxon 7227 90
type: UnificationXref
id: 7227
db: ncbitaxon

Branched-chain-amino-acid aminotransferase
type: ProteinReference
xref: uniprot Q6AT43 75
organism: Oryza sativa

uniprot P30126 123
type: UnificationXref
id: P30126
db: uniprot

NAD
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE