Lipoyl synthase
type: ProteinReference
xref: uniprot Q9RWA4 69
organism: Deinococcus radiodurans

AGAP000530-PA
type: ProteinReference
xref: uniprot Q5TV84 16
organism: Anopheles gambiae

Octanoyltransferase
type: ProteinReference
xref: uniprot Q9RWA5 26
organism: Deinococcus radiodurans

Octanoyltransferase, mitochondrial
type: ProteinReference
xref: uniprot Q06005 14
organism: Saccharomyces cerevisiae

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 67

Lipoyl synthase, mitochondrial
type: ProteinReference
xref: uniprot Q9ZWT1 71
organism: Arabidopsis thaliana

uniprot Q5ZAQ2 59
type: UnificationXref
id: Q5ZAQ2
db: uniprot

2 SAM
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

AGAP010568-PA (Fragment)
type: ProteinReference
xref: uniprot Q7Q8T4 62
organism: Anopheles gambiae

ncbitaxon 9598 37
type: UnificationXref
id: 9598
db: ncbitaxon

STATE_TRANSITION_LEFT__Octanoic_Acid-_ACP-RIGHT__octanoyl_ACP-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 72
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 74
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 73
left: ACP
left: Octanoic Acid
interaction type: STATE_TRANSITION
right: octanoyl-ACP

Putative lipoyltransferase 2, mitochondrial
type: ProteinReference
xref: uniprot D3Z9Z2 4
organism: Rattus norvegicus

Apo Lipoyl dependent proteins
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8ZUR4 20
type: UnificationXref
id: Q8ZUR4
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 17

ncbitaxon 39947 60
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot Q21452 52
type: UnificationXref
id: Q21452
db: uniprot

Lipoyl synthase
type: ProteinReference
xref: uniprot P9WK91 51
organism: Mycobacterium tuberculosis

uniprot P60720 8
type: UnificationXref
id: P60720
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__octanoyl_ACP-_2___SAM-RIGHT__2_methyladenosyl-_Lipoyl_ACP-_2_methionine-_r4
controller: Lipoate synthase

Putative lipoyltransferase 2, mitochondrial
type: ProteinReference
xref: uniprot Q9D009 24
organism: Mus musculus

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 40

uniprot O36017 6
type: UnificationXref
id: O36017
db: uniprot

Octanoyltransferase
type: ProteinReference
xref: uniprot P9WK83 12
organism: Mycobacterium tuberculosis

Lipoyl synthase, mitochondrial
type: ProteinReference
xref: uniprot Q99M04 65
organism: Mus musculus

Bos taurus
type: BioSource
xref: ncbitaxon 9913 57

ncbitaxon 9615 33
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot Q5BIP7 56
type: UnificationXref
id: Q5BIP7
db: uniprot

uniprot P32875 47
type: UnificationXref
id: P32875
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 35

Lipoyl synthase, mitochondrial
type: ProteinReference
xref: uniprot P32875 47
organism: Saccharomyces cerevisiae

ncbitaxon 3702 23
type: UnificationXref
id: 3702
db: ncbitaxon

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 46

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Apo_Lipoyl_dependent_proteins-_Lipoyl_ACP-RIGHT__Lipoyl_proteins-_ACP-_r5
controller: Lipoyl-protein ligase

ncbitaxon 559292 15
type: UnificationXref
id: 559292
db: ncbitaxon

Mus musculus
type: BioSource
xref: ncbitaxon 10090 25

PARTICIPANT STOICHIOMETRY r4 83
type: Stoichiometry
physical entity: 2 methionine
stoichiometric coefficient: 1.0

uniprot Q9X6V9 30
type: UnificationXref
id: Q9X6V9
db: uniprot

PARTICIPANT STOICHIOMETRY r4 82
type: Stoichiometry
physical entity: Lipoyl-ACP
stoichiometric coefficient: 1.0

Lipoyl synthase, mitochondrial
type: ProteinReference
xref: uniprot Q5BIP7 56
organism: Bos taurus

Lipoyl synthase, mitochondrial
type: ProteinReference
xref: uniprot Q21452 52
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r4 81
type: Stoichiometry
physical entity: 2 methyladenosyl
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 80
type: Stoichiometry
physical entity: 2 SAM
stoichiometric coefficient: 1.0

uniprot Q8ZUR9 64
type: UnificationXref
id: Q8ZUR9
db: uniprot

uniprot Q06005 14
type: UnificationXref
id: Q06005
db: uniprot

PARTICIPANT STOICHIOMETRY r3 74
type: Stoichiometry
physical entity: octanoyl-ACP
stoichiometric coefficient: 1.0

2 methionine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r3 72
type: Stoichiometry
physical entity: Octanoic Acid
stoichiometric coefficient: 1.0

uniprot Q8CK04 18
type: UnificationXref
id: Q8CK04
db: uniprot

PARTICIPANT STOICHIOMETRY r3 73
type: Stoichiometry
physical entity: ACP
stoichiometric coefficient: 1.0

uniprot H2QPC8 36
type: UnificationXref
id: H2QPC8
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 15

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 11

uniprot Q948J9 22
type: UnificationXref
id: Q948J9
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 29

Probable octanoyltransferase
type: ProteinReference
xref: uniprot Q8ZUR4 20
organism: Pyrobaculum aerophilum

ncbitaxon 10116 5
type: UnificationXref
id: 10116
db: ncbitaxon

ncbitaxon 1111708 11
type: UnificationXref
id: 1111708
db: ncbitaxon

Lipoyl-ACP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F6RMC6 34
type: UnificationXref
id: F6RMC6
db: uniprot

uniprot Q7JQW6 61
type: UnificationXref
id: Q7JQW6
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 3

uniprot D3Z9Z2 4
type: UnificationXref
id: D3Z9Z2
db: uniprot

uniprot Q4QDI6 54
type: UnificationXref
id: Q4QDI6
db: uniprot

Lipoate-protein ligase B, putative (Fragment)
type: ProteinReference
xref: uniprot B7P6C0 2
organism: Ixodes scapularis

uniprot Q9S2P2 70
type: UnificationXref
id: Q9S2P2
db: uniprot

PARTICIPANT STOICHIOMETRY r5 75
type: Stoichiometry
physical entity: Apo Lipoyl dependent proteins
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 76
type: Stoichiometry
physical entity: Lipoyl-ACP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 79
type: Stoichiometry
physical entity: octanoyl-ACP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 77
type: Stoichiometry
physical entity: Lipoyl proteins
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 78
type: Stoichiometry
physical entity: ACP
stoichiometric coefficient: 1.0

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 5

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 44

P03003
type: UnificationXref
id: P03003
db: PANTHER Pathway Component

P03004
type: UnificationXref
id: P03004
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Octanoic_Acid-_ACP-RIGHT__octanoyl_ACP-_r3
controller: ACP Acyltransferase

Octanoyltransferase LIP2p, chloroplastic
type: ProteinReference
xref: uniprot Q948J9 22
organism: Arabidopsis thaliana

ncbitaxon 83332 13
type: UnificationXref
id: 83332
db: ncbitaxon

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 33

Lipoyl synthase, mitochondrial
type: ProteinReference
xref: uniprot Q4QDI6 54
organism: Leishmania major

ncbitaxon 178306 21
type: UnificationXref
id: 178306
db: ncbitaxon

Octanoyltransferase
type: ProteinReference
xref: uniprot P74519 10
organism: Synechocystis

uniprot Q9VN27 28
type: UnificationXref
id: Q9VN27
db: uniprot

uniprot O13642 38
type: UnificationXref
id: O13642
db: uniprot

Lipoyl synthase, mitochondrial
type: ProteinReference
xref: uniprot Q7JQW6 61
organism: Drosophila melanogaster

Lipoyl synthase, mitochondrial
type: ProteinReference
xref: uniprot O43766 41
organism: Homo sapiens

ncbitaxon 224308 40
type: UnificationXref
id: 224308
db: ncbitaxon

uniprot O43766 41
type: UnificationXref
id: O43766
db: uniprot

Lipoate synthase
type: Protein
entity reference: Lipoate synthase
comment: SPECIES_TYPE=PROTEIN

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 21

ncbitaxon 6945 3
type: UnificationXref
id: 6945
db: ncbitaxon

uniprot P74519 10
type: UnificationXref
id: P74519
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 7

Putative lipoyltransferase 2, mitochondrial
type: ProteinReference
xref: uniprot Q9VN27 28
organism: Drosophila melanogaster

Probable octanoyltransferase
type: ProteinReference
xref: uniprot O36017 6
organism: Schizosaccharomyces pombe

PANTHER Pathway P02750 1
type: UnificationXref
id: P02750
db: PANTHER Pathway

uniprot Q9RWA4 69
type: UnificationXref
id: Q9RWA4
db: uniprot

uniprot Q8LEE8 63
type: UnificationXref
id: Q8LEE8
db: uniprot

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 19

ncbitaxon 6239 53
type: UnificationXref
id: 6239
db: ncbitaxon

ncbitaxon 7227 29
type: UnificationXref
id: 7227
db: ncbitaxon

ncbitaxon 208964 31
type: UnificationXref
id: 208964
db: ncbitaxon

Lipoyl synthase, chloroplastic
type: ProteinReference
xref: uniprot Q8LEE8 63
organism: Arabidopsis thaliana

ncbitaxon 100226 19
type: UnificationXref
id: 100226
db: ncbitaxon

Lipoyl-protein ligase
type: Protein
entity reference: Lipoyl-protein ligase
comment: SPECIES_TYPE=PROTEIN

uniprot P73572 50
type: UnificationXref
id: P73572
db: uniprot

STATE_TRANSITION_LEFT__Apo_Lipoyl_dependent_proteins-_Lipoyl_ACP-RIGHT__Lipoyl_proteins-_ACP-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 78
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 76
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 77
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 75
left: Lipoyl-ACP
left: Apo Lipoyl dependent proteins
interaction type: STATE_TRANSITION
right: ACP
right: Lipoyl proteins

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 37

Lipoyl proteins
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 224324 44
type: UnificationXref
id: 224324
db: ncbitaxon

uniprot P72980 49
type: UnificationXref
id: P72980
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

uniprot Q5XIH4 58
type: UnificationXref
id: Q5XIH4
db: uniprot

Lipoyl synthase
type: ProteinReference
xref: uniprot O67368 43
organism: Aquifex aeolicus

uniprot Q9ZWT1 71
type: UnificationXref
id: Q9ZWT1
db: uniprot

Probable lipoyl synthase
type: ProteinReference
xref: uniprot Q9HN78 66
organism: Halobacterium salinarum

ncbitaxon 7165 17
type: UnificationXref
id: 7165
db: ncbitaxon

ncbitaxon 243230 27
type: UnificationXref
id: 243230
db: ncbitaxon

ACP Acyltransferase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Octanoyltransferase
type: ProteinReference
xref: uniprot P60720 8
organism: Escherichia coli

Octanoic Acid
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9913 57
type: UnificationXref
id: 9913
db: ncbitaxon

Lipoyl synthase, mitochondrial
type: ProteinReference
xref: uniprot F6RMC6 34
organism: Macaca mulatta

Lipoyl synthase
type: ProteinReference
xref: uniprot O32129 39
organism: Bacillus subtilis

ncbitaxon 284812 7
type: UnificationXref
id: 284812
db: ncbitaxon

ncbitaxon 9606 42
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot Q9HX25 68
type: UnificationXref
id: Q9HX25
db: uniprot

2 methyladenosyl
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9RWA5 26
type: UnificationXref
id: Q9RWA5
db: uniprot

Probable lipoyl synthase
type: ProteinReference
xref: uniprot Q8ZUR9 64
organism: Pyrobaculum aerophilum

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 27

STATE_TRANSITION_LEFT__octanoyl_ACP-_2___SAM-RIGHT__2_methyladenosyl-_Lipoyl_ACP-_2_methionine-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 81
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 83
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 82
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 79
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 80
left: octanoyl-ACP
left: 2 SAM
interaction type: STATE_TRANSITION
right: Lipoyl-ACP
right: 2 methyladenosyl
right: 2 methionine

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 42

uniprot O84562 45
type: UnificationXref
id: O84562
db: uniprot

uniprot Q9HN78 66
type: UnificationXref
id: Q9HN78
db: uniprot

Lipoate synthase
type: ProteinReference
xref: P03004
comment: ENTITY_REFERENCE_ID_DESC=Lipoate_biosynthesis.PROTEIN.GENERIC.Lipoate synthase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Lipoate synthase Synonym: Synonym not specified Accession: P03004
member entity reference: Lipoyl synthase
member entity reference: Lipoyl synthase, mitochondrial
member entity reference: AGAP010568-PA (Fragment)
member entity reference: Lipoyl synthase 1
member entity reference: Probable lipoyl synthase
member entity reference: Lipoyl synthase 2
member entity reference: Lipoyl synthase 1, chloroplastic
member entity reference: Lipoyl synthase, chloroplastic

Lipoyl synthase
type: ProteinReference
xref: uniprot P60716 48
organism: Escherichia coli

uniprot Q5TV84 16
type: UnificationXref
id: Q5TV84
db: uniprot

uniprot E2R257 32
type: UnificationXref
id: E2R257
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 55

Lipoyl synthase
type: ProteinReference
xref: uniprot Q9HX25 68
organism: Pseudomonas aeruginosa

Lipoyl-protein ligase
type: ProteinReference
xref: P03003
comment: ENTITY_REFERENCE_ID_DESC=Lipoate_biosynthesis.PROTEIN.GENERIC.Lipoyl-protein ligase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Lipoyl-protein ligase Synonym: Synonym not specified Accession: P03003
member entity reference: Putative lipoyltransferase 2, mitochondrial
member entity reference: Octanoyltransferase
member entity reference: Octanoyltransferase LIP2p, chloroplastic
member entity reference: AGAP000530-PA
member entity reference: Lipoate-protein ligase B, putative (Fragment)
member entity reference: Octanoyltransferase, mitochondrial
member entity reference: Probable octanoyltransferase

ncbitaxon 10090 25
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot O67368 43
type: UnificationXref
id: O67368
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 23

ncbitaxon 83333 9
type: UnificationXref
id: 83333
db: ncbitaxon

ncbitaxon 9544 35
type: UnificationXref
id: 9544
db: ncbitaxon

ncbitaxon 272561 46
type: UnificationXref
id: 272561
db: ncbitaxon

Lipoyl synthase, mitochondrial
type: ProteinReference
xref: uniprot E2R257 32
organism: Canis lupus familiaris

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 53

uniprot Q9D009 24
type: UnificationXref
id: Q9D009
db: uniprot

Lipoyl synthase
type: ProteinReference
xref: uniprot O84562 45
organism: Chlamydia trachomatis

Lipoyl synthase
type: ProteinReference
xref: uniprot Q9S2P2 70
organism: Streptomyces coelicolor

Lipoyl synthase 2
type: ProteinReference
xref: uniprot P73572 50
organism: Synechocystis

Lipoyl synthase, mitochondrial
type: ProteinReference
xref: uniprot H2QPC8 36
organism: Pan troglodytes

ncbitaxon 64091 67
type: UnificationXref
id: 64091
db: ncbitaxon

Lipoyl synthase 1
type: ProteinReference
xref: uniprot P72980 49
organism: Synechocystis

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 13

uniprot B7P6C0 2
type: UnificationXref
id: B7P6C0
db: uniprot

Lipoate_biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Apo_Lipoyl_dependent_proteins-_Lipoyl_ACP-RIGHT__Lipoyl_proteins-_ACP-_r5
pathway component: STATE_TRANSITION_LEFT__Octanoic_Acid-_ACP-RIGHT__octanoyl_ACP-_r3
pathway component: STATE_TRANSITION_LEFT__octanoyl_ACP-_2___SAM-RIGHT__2_methyladenosyl-_Lipoyl_ACP-_2_methionine-_r4
xref: PANTHER Pathway P02750 1
comment: MODEL_NOTES= The biosynthesis of the cofactor lipoate. Lipoate is active when bound to its congnate proteins and functions to bind and transport acyl groups via a thioester linkage. Website=www.biocyc.org/Ecoli/Pathways/ free text=Voet and Voet (textbook) Biochemistry

Octanoyltransferase
type: ProteinReference
xref: uniprot Q9X6V9 30
organism: Pseudomonas aeruginosa

uniprot Q99M04 65
type: UnificationXref
id: Q99M04
db: uniprot

uniprot Q7Q8T4 62
type: UnificationXref
id: Q7Q8T4
db: uniprot

uniprot O32129 39
type: UnificationXref
id: O32129
db: uniprot

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 9

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 60

uniprot P9WK91 51
type: UnificationXref
id: P9WK91
db: uniprot

octanoyl-ACP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 31

ncbitaxon 5664 55
type: UnificationXref
id: 5664
db: ncbitaxon

Lipoyl synthase, mitochondrial
type: ProteinReference
xref: uniprot Q5XIH4 58
organism: Rattus norvegicus

ACP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P60716 48
type: UnificationXref
id: P60716
db: uniprot

Lipoyl synthase 1, chloroplastic
type: ProteinReference
xref: uniprot Q5ZAQ2 59
organism: Oryza sativa

uniprot P9WK83 12
type: UnificationXref
id: P9WK83
db: uniprot

Lipoyl synthase, mitochondrial
type: ProteinReference
xref: uniprot O13642 38
organism: Schizosaccharomyces pombe

Octanoyltransferase
type: ProteinReference
xref: uniprot Q8CK04 18
organism: Streptomyces coelicolor