ncbitaxon 515635 107
type: UnificationXref
id: 515635
db: ncbitaxon

L-aspartate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9RUL9 101
type: UnificationXref
id: Q9RUL9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__2,3_dihydrodipicolinate-_NADPH-RIGHT__tetrahydrodipicolinate-_NADP-_r4
controller: Dihydrodipicolinate reductase

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 64

uniprot P9WPZ7 120
type: UnificationXref
id: P9WPZ7
db: uniprot

aspartyl-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8LB01 22
type: UnificationXref
id: Q8LB01
db: uniprot

4-hydroxy-tetrahydrodipicolinate synthase 1
type: ProteinReference
xref: uniprot Q9X9W0 72
organism: Streptomyces coelicolor

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot O67716 130
organism: Aquifex aeolicus

STATE_TRANSITION_LEFT__aspartyl_phosphate-_NADPH-RIGHT__aspartate_semialdehyde_-_NADP-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 161
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 163
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 164
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 162
left: NADPH
left: aspartyl-phosphate
interaction type: STATE_TRANSITION
right: NADP
right: aspartate semialdehyde

PARTICIPANT STOICHIOMETRY r1 166
type: Stoichiometry
physical entity: L-aspartate
stoichiometric coefficient: 1.0

PTHR11986:SF113
type: RelationshipXref
id: PTHR11986:SF113
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r1 165
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Dihydrodipicolinate reductase
type: ProteinReference
xref: P03006
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Lysine biosynthesis.PROTEIN.GENERIC.Dihydrodipicolinate_br_ reductase
comment: ENTITY_REFERENCE_NOTES= Long Name: Dihydrodipicolinate reductase Synonym: Synonym not specified Accession: P03006
member entity reference: 4-hydroxy-tetrahydrodipicolinate reductase
member entity reference: 4-hydroxy-tetrahydrodipicolinate reductase 2, chloroplastic
member entity reference: Dihydrodipicolinate reductase
member entity reference: 4-hydroxy-tetrahydrodipicolinate reductase 1, chloroplastic
member entity reference: Dihydrodipicolinate reductase-like protein CRR1, chloroplastic

PARTICIPANT STOICHIOMETRY r1 168
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PTHR11986:SF115
type: RelationshipXref
id: PTHR11986:SF115
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__meso_diaminopimelate-RIGHT__L_lysine-_CO2-_re12
controller: Diaminopimelate decarboxylase

PARTICIPANT STOICHIOMETRY r1 167
type: Stoichiometry
physical entity: aspartyl-phosphate
stoichiometric coefficient: 1.0

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 15

4-hydroxy-tetrahydrodipicolinate reductase 2, chloroplastic
type: ProteinReference
xref: uniprot Q8LB01 22
organism: Arabidopsis thaliana

uniprot Q58131 121
type: UnificationXref
id: Q58131
db: uniprot

ncbitaxon 83332 33
type: UnificationXref
id: 83332
db: ncbitaxon

USG-1 protein
type: ProteinReference
xref: uniprot P08390 131
organism: Escherichia coli

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_L_aspartate-RIGHT__aspartyl_phosphate-_ADP-_r1
controller: Aspartokinase

4-hydroxy-tetrahydrodipicolinate reductase
type: ProteinReference
xref: uniprot O84369 6
organism: Chlamydia trachomatis

ncbitaxon 1111708 35
type: UnificationXref
id: 1111708
db: ncbitaxon

ncbitaxon 178306 61
type: UnificationXref
id: 178306
db: ncbitaxon

Aspartokinase
type: ProteinReference
xref: uniprot O84367 79
organism: Chlamydia trachomatis

PARTICIPANT STOICHIOMETRY r3 157
type: Stoichiometry
physical entity: pyruvate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 158
type: Stoichiometry
physical entity: aspartate semialdehyde
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 159
type: Stoichiometry
physical entity: 2 H2O
stoichiometric coefficient: 1.0

4-hydroxy-tetrahydrodipicolinate synthase
type: ProteinReference
xref: uniprot O84366 51
organism: Chlamydia trachomatis

PARTICIPANT STOICHIOMETRY re10 155
type: Stoichiometry
physical entity: succinate
stoichiometric coefficient: 1.0

Probable acetylornithine aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot O74548 114
organism: Schizosaccharomyces pombe

PARTICIPANT STOICHIOMETRY re10 156
type: Stoichiometry
physical entity: LL-diaminopimelate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 153
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot Q7NLV2 133
organism: Gloeobacter violaceus

PARTICIPANT STOICHIOMETRY re10 154
type: Stoichiometry
physical entity: N-succinyl-diaminopimelate
stoichiometric coefficient: 1.0

4-hydroxy-tetrahydrodipicolinate synthase
type: ProteinReference
xref: uniprot P9WP25 55
organism: Mycobacterium tuberculosis

Homoserine dehydrogenase
type: ProteinReference
xref: uniprot F4K6Y8 74
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r3 160
type: Stoichiometry
physical entity: 2,3-dihydrodipicolinate
stoichiometric coefficient: 1.0

ncbitaxon 367110 89
type: UnificationXref
id: 367110
db: ncbitaxon

4-hydroxy-tetrahydrodipicolinate reductase
type: ProteinReference
xref: uniprot P42976 12
organism: Bacillus subtilis

Acetylornithine aminotransferase
type: ProteinReference
xref: uniprot Q58131 121
organism: Methanocaldococcus jannaschii

Aspartokinase
type: ProteinReference
xref: uniprot O67221 78
organism: Aquifex aeolicus

uniprot Q7UL17 134
type: UnificationXref
id: Q7UL17
db: uniprot

uniprot Q9XAI7 105
type: UnificationXref
id: Q9XAI7
db: uniprot

Dihydrodipicolinate reductase
type: Protein
entity reference: Dihydrodipicolinate reductase
comment: SPECIES_TYPE=PROTEIN

uniprot Q8S1X5 136
type: UnificationXref
id: Q8S1X5
db: uniprot

4-hydroxy-tetrahydrodipicolinate reductase
type: ProteinReference
xref: uniprot P04036 10
organism: Escherichia coli

N-succinly-2-amino-6-oxopimelate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot Q7UL17 134
organism: Rhodopirellula baltica

Homoserine dehydrogenase
type: ProteinReference
xref: uniprot Q7RZC2 93
organism: Neurospora crassa

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 7

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 27

4-hydroxy-tetrahydrodipicolinate synthase
type: ProteinReference
xref: uniprot O67216 50
organism: Aquifex aeolicus

Tetrahydropyridine-2,6-dicarboxylate-N-succinyltransferase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q58497 36
type: UnificationXref
id: Q58497
db: uniprot

ncbitaxon 6945 49
type: UnificationXref
id: 6945
db: ncbitaxon

ncbitaxon 39947 91
type: UnificationXref
id: 39947
db: ncbitaxon

aspartate semialdehyde
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P9WP25 55
type: UnificationXref
id: P9WP25
db: uniprot

[LysW]-aminoadipate semialdehyde transaminase
type: ProteinReference
xref: uniprot Q9RW75 127
organism: Deinococcus radiodurans

ncbitaxon 189518 21
type: UnificationXref
id: 189518
db: ncbitaxon

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 84

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 35

Probable dihydrodipicolinate synthetase
type: ProteinReference
xref: uniprot Q9I490 66
organism: Pseudomonas aeruginosa

uniprot Q04795 87
type: UnificationXref
id: Q04795
db: uniprot

P03010
type: UnificationXref
id: P03010
db: PANTHER Pathway Component

Aspartokinase
type: ProteinReference
xref: uniprot Q9XAI7 105
organism: Streptomyces coelicolor

Putative dihydropicolinate synthase
type: ProteinReference
xref: uniprot Q9X9Y3 73
organism: Streptomyces coelicolor

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot Q9XAI8 141
organism: Streptomyces coelicolor

P03011
type: UnificationXref
id: P03011
db: PANTHER Pathway Component

Putative decarboxylase
type: ProteinReference
xref: uniprot Q9RL03 43
organism: Streptomyces coelicolor

uniprot O84369 6
type: UnificationXref
id: O84369
db: uniprot

Aspartokinase 3
type: ProteinReference
xref: uniprot P94417 86
organism: Bacillus subtilis

IDA
type: EvidenceCodeVocabulary

P03013
type: UnificationXref
id: P03013
db: PANTHER Pathway Component

Aspartokinase
type: ProteinReference
xref: uniprot Q8A7Z9 97
organism: Bacteroides thetaiotaomicron

Diaminopimelate epimerase
type: ProteinReference
xref: uniprot Q8AAB7 109
organism: Bacteroides thetaiotaomicron

uniprot Q7NLC0 14
type: UnificationXref
id: Q7NLC0
db: uniprot

uniprot Q57695 58
type: UnificationXref
id: Q57695
db: uniprot

uniprot Q9RTK2 44
type: UnificationXref
id: Q9RTK2
db: uniprot

Diaminopimelate epimerase
type: ProteinReference
xref: P03010
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Lysine biosynthesis.PROTEIN.GENERIC.Diaminopimelate_br_epimerase
comment: ENTITY_REFERENCE_NOTES= Long Name: Diaminopimelate epimerase Synonym: Synonym not specified Accession: P03010
member entity reference: Diaminopimelate epimerase
member entity reference: Diaminopimelate epimerase, chloroplastic

uniprot Q9RSW3 139
type: UnificationXref
id: Q9RSW3
db: uniprot

succinyl-CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Aspartokinase
type: Protein
entity reference: Aspartokinase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 243274 27
type: UnificationXref
id: 243274
db: ncbitaxon

uniprot P42976 12
type: UnificationXref
id: P42976
db: uniprot

ncbitaxon 64091 64
type: UnificationXref
id: 64091
db: ncbitaxon

P03008
type: UnificationXref
id: P03008
db: PANTHER Pathway Component

P03007
type: UnificationXref
id: P03007
db: PANTHER Pathway Component

uniprot Q8TTK1 137
type: UnificationXref
id: Q8TTK1
db: uniprot

uniprot Q8ZU75 60
type: UnificationXref
id: Q8ZU75
db: uniprot

P03009
type: UnificationXref
id: P03009
db: PANTHER Pathway Component

ncbitaxon 208964 30
type: UnificationXref
id: 208964
db: ncbitaxon

ncbitaxon 272561 7
type: UnificationXref
id: 272561
db: ncbitaxon

ncbitaxon 243230 45
type: UnificationXref
id: 243230
db: ncbitaxon

P03006
type: UnificationXref
id: P03006
db: PANTHER Pathway Component

uniprot Q8A7Z9 97
type: UnificationXref
id: Q8A7Z9
db: uniprot

uniprot Q9X9W0 72
type: UnificationXref
id: Q9X9W0
db: uniprot

N-succinyl-diaminopimelate desuccinylase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 89

uniprot Q8F865 98
type: UnificationXref
id: Q8F865
db: uniprot

uniprot Q55484 34
type: UnificationXref
id: Q55484
db: uniprot

uniprot Q8TUE8 122
type: UnificationXref
id: Q8TUE8
db: uniprot

uniprot P77581 119
type: UnificationXref
id: P77581
db: uniprot

Acetylornithine aminotransferase
type: ProteinReference
xref: uniprot P73133 118
organism: Synechocystis

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 19

uniprot Q9X1K6 104
type: UnificationXref
id: Q9X1K6
db: uniprot

Aspartokinase/homoserine dehydrogenase
type: ProteinReference
xref: uniprot Q8A541 95
organism: Bacteroides thetaiotaomicron

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__pyruvate-_aspartate_semialdehyde_-RIGHT__2_H2O-_2,3_dihydrodipicolinate-_r3
controller: Dihydrodipicolinate synthase

uniprot Q9P3I3 126
type: UnificationXref
id: Q9P3I3
db: uniprot

Aspartate kinase-homoserine dehydrogenase
type: ProteinReference
xref: uniprot Q69LG7 90
organism: Oryza sativa

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 77

uniprot Q9LQ96 138
type: UnificationXref
id: Q9LQ96
db: uniprot

N-succinyldiaminopimelate aminotransferase
type: Protein
entity reference: N-succinyldiaminopimelate aminotransferase
comment: SPECIES_TYPE=PROTEIN

uniprot Q9SA18 102
type: UnificationXref
id: Q9SA18
db: uniprot

PARTICIPANT STOICHIOMETRY re12 170
type: Stoichiometry
physical entity: L-lysine
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__aspartyl_phosphate-_NADPH-RIGHT__aspartate_semialdehyde_-_NADP-_r2
controller: Aspartate semialdehyde dehydrogenase

2 H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

4-hydroxy-tetrahydrodipicolinate synthase 2
type: ProteinReference
xref: uniprot O86841 52
organism: Streptomyces coelicolor

STATE_TRANSITION_LEFT__N_succinly_2_amino_6_oxopimelate-_glutamate-RIGHT__ketoglutarate-_N_succinyl_diaminopimelate-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 172
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 174
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 173
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 175
left: N-succinly-2-amino-6-oxopimelate
left: glutamate
interaction type: STATE_TRANSITION
right: ketoglutarate
right: N-succinyl-diaminopimelate

uniprot P18544 115
type: UnificationXref
id: P18544
db: uniprot

ncbitaxon 3702 5
type: UnificationXref
id: 3702
db: ncbitaxon

STATE_TRANSITION_LEFT__H2O-_N_succinyl_diaminopimelate-RIGHT__succinate-_LL_diaminopimelate-_re10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 155
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 154
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 156
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 153
left: H2O
left: N-succinyl-diaminopimelate
interaction type: STATE_TRANSITION
right: succinate
right: LL-diaminopimelate

PANTHER Pathway P02751 1
type: UnificationXref
id: P02751
db: PANTHER Pathway

Succinylornithine transaminase
type: ProteinReference
xref: uniprot P77581 119
xref: PTHR11986:SF115
organism: Escherichia coli

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot Q9RSW3 139
organism: Deinococcus radiodurans

ncbitaxon 243090 17
type: UnificationXref
id: 243090
db: ncbitaxon

meso-diaminopimelate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re12 169
type: Stoichiometry
physical entity: meso-diaminopimelate
stoichiometric coefficient: 1.0

uniprot O67061 2
type: UnificationXref
id: O67061
db: uniprot

4-hydroxy-tetrahydrodipicolinate synthase
type: ProteinReference
xref: uniprot Q9I4W3 67
organism: Pseudomonas aeruginosa

Diaminopimelate decarboxylase
type: ProteinReference
xref: uniprot Q55484 34
organism: Synechocystis

4-hydroxy-tetrahydrodipicolinate reductase
type: ProteinReference
xref: uniprot O86836 8
organism: Streptomyces coelicolor

Aspartate kinase
type: ProteinReference
xref: uniprot Q7NJQ8 92
organism: Gloeobacter violaceus

uniprot B8DZX7 106
type: UnificationXref
id: B8DZX7
db: uniprot

Acetylornithine aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot Q9P3I3 126
organism: Neurospora crassa

Lysine-sensitive aspartokinase 3
type: ProteinReference
xref: uniprot P08660 82
organism: Escherichia coli

uniprot B9DGS8 129
type: UnificationXref
id: B9DGS8
db: uniprot

CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 21

PARTICIPANT STOICHIOMETRY re12 171
type: Stoichiometry
physical entity: CO2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 174
type: Stoichiometry
physical entity: ketoglutarate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 173
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 45

PARTICIPANT STOICHIOMETRY r6 172
type: Stoichiometry
physical entity: N-succinly-2-amino-6-oxopimelate
stoichiometric coefficient: 1.0

ketoglutarate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Aspartokinase
type: ProteinReference
xref: uniprot Q9RUL9 101
organism: Deinococcus radiodurans

PARTICIPANT STOICHIOMETRY r6 175
type: Stoichiometry
physical entity: N-succinyl-diaminopimelate
stoichiometric coefficient: 1.0

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 37

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 224324 3
type: UnificationXref
id: 224324
db: ncbitaxon

CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 251221 15
type: UnificationXref
id: 251221
db: ncbitaxon

Diaminopimelate decarboxylase
type: Protein
entity reference: Diaminopimelate decarboxylase
comment: SPECIES_TYPE=PROTEIN

Uncharacterized DapA-like lyase PAE2915
type: ProteinReference
xref: uniprot Q8ZU75 60
organism: Pyrobaculum aerophilum

uniprot Q9L1A4 124
type: UnificationXref
id: Q9L1A4
db: uniprot

uniprot Q9I6R5 68
type: UnificationXref
id: Q9I6R5
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 5

Diaminopimelate decarboxylase
type: ProteinReference
xref: uniprot Q9RTK2 44
organism: Deinococcus radiodurans

NADPH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8A541 95
type: UnificationXref
id: Q8A541
db: uniprot

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot Q8TTK1 137
organism: Methanosarcina acetivorans

Lysine-sensitive aspartokinase III
type: ProteinReference
xref: uniprot Q8A6I3 96
organism: Bacteroides thetaiotaomicron

uniprot P10869 83
type: UnificationXref
id: P10869
db: uniprot

Diaminopimelate decarboxylase 1, chloroplastic
type: ProteinReference
xref: uniprot Q949X7 41
organism: Arabidopsis thaliana

uniprot Q7RZC2 93
type: UnificationXref
id: Q7RZC2
db: uniprot

Diaminopimelate decarboxylase
type: ProteinReference
xref: uniprot P9WIU7 32
organism: Mycobacterium tuberculosis

uniprot Q9X1K8 26
type: UnificationXref
id: Q9X1K8
db: uniprot

uniprot Q8TSR9 40
type: UnificationXref
id: Q8TSR9
db: uniprot

Dihydrodipicolinate reductase
type: ProteinReference
xref: uniprot Q8A2I5 18
organism: Bacteroides thetaiotaomicron

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 33

Lysine biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__LL_diaminopimelate-RIGHT__meso_diaminopimelate-_re11
pathway component: STATE_TRANSITION_LEFT__N_succinly_2_amino_6_oxopimelate-_glutamate-RIGHT__ketoglutarate-_N_succinyl_diaminopimelate-_r6
pathway component: STATE_TRANSITION_LEFT__ATP-_L_aspartate-RIGHT__aspartyl_phosphate-_ADP-_r1
pathway component: STATE_TRANSITION_LEFT__tetrahydrodipicolinate-_succinyl_CoA-RIGHT__H2O-_N_succinly_2_amino_6_oxopimelate-_CoA-_r5
pathway component: STATE_TRANSITION_LEFT__2,3_dihydrodipicolinate-_NADPH-RIGHT__tetrahydrodipicolinate-_NADP-_r4
pathway component: STATE_TRANSITION_LEFT__aspartyl_phosphate-_NADPH-RIGHT__aspartate_semialdehyde_-_NADP-_r2
pathway component: STATE_TRANSITION_LEFT__pyruvate-_aspartate_semialdehyde_-RIGHT__2_H2O-_2,3_dihydrodipicolinate-_r3
pathway component: STATE_TRANSITION_LEFT__meso_diaminopimelate-RIGHT__L_lysine-_CO2-_re12
pathway component: STATE_TRANSITION_LEFT__H2O-_N_succinyl_diaminopimelate-RIGHT__succinate-_LL_diaminopimelate-_re10
xref: PANTHER Pathway P02751 1
comment: MODEL_NOTES= Bacterial biosynthesis of the amino acid lysine. Critical for protein biosynthesis and a component of the peptidoglycan layer of bacterial cell walls. Website=www.biocyc.org/Ecoli free text=Voet and Voet Biochemistry

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__LL_diaminopimelate-RIGHT__meso_diaminopimelate-_re11
controller: Diaminopimelate epimerase

Acetylornithine aminotransferase
type: ProteinReference
xref: uniprot O66442 113
organism: Aquifex aeolicus

uniprot Q9X9Y3 73
type: UnificationXref
id: Q9X9Y3
db: uniprot

4-hydroxy-tetrahydrodipicolinate reductase
type: ProteinReference
xref: uniprot Q8F133 20
organism: Leptospira interrogans

uniprot O84366 51
type: UnificationXref
id: O84366
db: uniprot

Probable aspartokinase
type: ProteinReference
xref: uniprot Q7UMB6 94
organism: Rhodopirellula baltica

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 11

uniprot P08495 81
type: UnificationXref
id: P08495
db: uniprot

uniprot P31116 85
type: UnificationXref
id: P31116
db: uniprot

PARTICIPANT STOICHIOMETRY r5 145
type: Stoichiometry
physical entity: N-succinly-2-amino-6-oxopimelate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 146
type: Stoichiometry
physical entity: CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 143
type: Stoichiometry
physical entity: succinyl-CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 144
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 142
type: Stoichiometry
physical entity: tetrahydrodipicolinate
stoichiometric coefficient: 1.0

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

4-hydroxy-tetrahydrodipicolinate synthase
type: ProteinReference
xref: uniprot Q9RH76 69
organism: Bradyrhizobium diazoefficiens

uniprot O74548 114
type: UnificationXref
id: O74548
db: uniprot

uniprot P19572 29
type: UnificationXref
id: P19572
db: uniprot

N-succinyldiaminopimelate aminotransferase
type: ProteinReference
xref: P03011
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Lysine biosynthesis.PROTEIN.GENERIC.N-succinyldiaminopimelate _br_aminotransferase
comment: ENTITY_REFERENCE_NOTES= Long Name: N-succinyldiaminopimelate aminotransferase Synonym: Synonym not specified Accession: P03011
member entity reference: Acetylornithine aminotransferase, chloroplastic/mitochondrial
member entity reference: Acetylornithine aminotransferase
member entity reference: Acetylornithine aminotransferase, mitochondrial
member entity reference: Putative [LysW]-aminoadipate semialdehyde/glutamate semialdehyde transaminase
member entity reference: Succinylornithine transaminase
member entity reference: Succinylornithine transaminase/acetylornithine aminotransferase
member entity reference: [LysW]-aminoadipate semialdehyde transaminase
member entity reference: Probable acetylornithine aminotransferase, mitochondrial

4-hydroxy-tetrahydrodipicolinate synthase
type: ProteinReference
xref: uniprot Q57695 58
organism: Methanocaldococcus jannaschii

Acetylornithine aminotransferase
type: ProteinReference
xref: uniprot Q9X2A5 128
organism: Thermotoga maritima

Diaminopimelate decarboxylase
type: ProteinReference
xref: uniprot Q58497 36
organism: Methanocaldococcus jannaschii

ncbitaxon 100226 9
type: UnificationXref
id: 100226
db: ncbitaxon

uniprot Q8A6I3 96
type: UnificationXref
id: Q8A6I3
db: uniprot

LL-diaminopimelate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9I4W3 67
type: UnificationXref
id: Q9I4W3
db: uniprot

Dihydrodipicolinate synthase
type: Protein
entity reference: Dihydrodipicolinate synthase
comment: SPECIES_TYPE=PROTEIN

4-hydroxy-tetrahydrodipicolinate reductase
type: ProteinReference
xref: uniprot Q7UJD7 16
organism: Rhodopirellula baltica

Diaminopimelate epimerase, chloroplastic
type: ProteinReference
xref: uniprot Q2QNF7 108
organism: Oryza sativa

Putative [LysW]-aminoadipate semialdehyde/glutamate semialdehyde transaminase
type: ProteinReference
xref: uniprot Q8ZV07 123
organism: Pyrobaculum aerophilum

Dictyoglomus turgidum
type: BioSource
xref: ncbitaxon 515635 107

uniprot Q55513 57
type: UnificationXref
id: Q55513
db: uniprot

Acetylornithine aminotransferase, mitochondrial
type: ProteinReference
xref: uniprot P18544 115
organism: Saccharomyces cerevisiae

uniprot P08390 131
type: UnificationXref
id: P08390
db: uniprot

uniprot P24087 116
type: UnificationXref
id: P24087
db: uniprot

uniprot Q9ZBH5 47
type: UnificationXref
id: Q9ZBH5
db: uniprot

uniprot Q8A2I5 18
type: UnificationXref
id: Q8A2I5
db: uniprot

PARTICIPANT STOICHIOMETRY re11 148
type: Stoichiometry
physical entity: meso-diaminopimelate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 147
type: Stoichiometry
physical entity: LL-diaminopimelate
stoichiometric coefficient: 1.0

Succinylornithine transaminase/acetylornithine aminotransferase
type: ProteinReference
xref: uniprot O30508 110
xref: PTHR11986:SF113
organism: Pseudomonas aeruginosa

uniprot Q9RL03 43
type: UnificationXref
id: Q9RL03
db: uniprot

uniprot O86841 52
type: UnificationXref
id: O86841
db: uniprot

Aspartokinase II
type: ProteinReference
xref: uniprot Q9WZ17 103
organism: Thermotoga maritima

Acetylornithine aminotransferase
type: ProteinReference
xref: uniprot P9WPZ7 120
organism: Mycobacterium tuberculosis

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 13

uniprot Q9WZ17 103
type: UnificationXref
id: Q9WZ17
db: uniprot

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 39

Homoserine dehydrogenase
type: ProteinReference
xref: uniprot P31116 85
organism: Saccharomyces cerevisiae

ncbitaxon 284812 77
type: UnificationXref
id: 284812
db: ncbitaxon

Aspartokinase 2, chloroplastic
type: ProteinReference
xref: uniprot O23653 75
organism: Arabidopsis thaliana

uniprot Q9I490 66
type: UnificationXref
id: Q9I490
db: uniprot

ncbitaxon 188937 24
type: UnificationXref
id: 188937
db: ncbitaxon

uniprot O84367 79
type: UnificationXref
id: O84367
db: uniprot

uniprot Q9LYU8 100
type: UnificationXref
id: Q9LYU8
db: uniprot

uniprot Q9RH76 69
type: UnificationXref
id: Q9RH76
db: uniprot

Aspartokinase 2
type: ProteinReference
xref: uniprot P08495 81
organism: Bacillus subtilis

ncbitaxon 44689 39
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot O23653 75
type: UnificationXref
id: O23653
db: uniprot

STATE_TRANSITION_LEFT__2,3_dihydrodipicolinate-_NADPH-RIGHT__tetrahydrodipicolinate-_NADP-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 152
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 149
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 150
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 151
left: NADPH
left: 2,3-dihydrodipicolinate
interaction type: STATE_TRANSITION
right: NADP
right: tetrahydrodipicolinate

Diaminopimelate decarboxylase
type: ProteinReference
xref: P03007
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Diaminopimelate decarboxylase Synonym: Synonym not specified Accession: P03007
comment: ENTITY_REFERENCE_ID_DESC=Lysine biosynthesis.PROTEIN.GENERIC.Diaminopimelate_br_decarboxylase
member entity reference: Diaminopimelate decarboxylase
member entity reference: Diaminopimelate decarboxylase 2, chloroplastic
member entity reference: Diaminopimelate decarboxylase 1, chloroplastic
member entity reference: Putative decarboxylase
member entity reference: Uncharacterized protein

succinate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O67262 28
type: UnificationXref
id: O67262
db: uniprot

N-succinyl-diaminopimelate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9X1L1 140
type: UnificationXref
id: Q9X1L1
db: uniprot

uniprot Q1K7N1 88
type: UnificationXref
id: Q1K7N1
db: uniprot

uniprot Q9HS19 63
type: UnificationXref
id: Q9HS19
db: uniprot

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8F133 20
type: UnificationXref
id: Q8F133
db: uniprot

Diaminopimelate decarboxylase 2, chloroplastic
type: ProteinReference
xref: uniprot Q94A94 42
organism: Arabidopsis thaliana

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 24

uniprot Q7UJD7 16
type: UnificationXref
id: Q7UJD7
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 49

ncbitaxon 243232 37
type: UnificationXref
id: 243232
db: ncbitaxon

NADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Aspartokinase
type: ProteinReference
xref: uniprot Q1K7N1 88
organism: Neurospora crassa

4-hydroxy-tetrahydrodipicolinate synthase
type: ProteinReference
xref: uniprot Q04796 56
organism: Bacillus subtilis

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot Q04797 132
organism: Bacillus subtilis

Diaminopimelate decarboxylase
type: ProteinReference
xref: uniprot Q9ZBH5 47
organism: Streptomyces coelicolor

Probable 2-dehydro-3-deoxy-D-pentonate aldolase YjhH
type: ProteinReference
xref: uniprot P39359 53
organism: Escherichia coli

uniprot Q8THP1 59
type: UnificationXref
id: Q8THP1
db: uniprot

uniprot Q8THP0 23
type: UnificationXref
id: Q8THP0
db: uniprot

Probable homoserine dehydrogenase
type: ProteinReference
xref: uniprot O94671 80
organism: Schizosaccharomyces pombe

uniprot Q9XAI8 141
type: UnificationXref
id: Q9XAI8
db: uniprot

ncbitaxon 224911 70
type: UnificationXref
id: 224911
db: ncbitaxon

uniprot Q9X1K5 46
type: UnificationXref
id: Q9X1K5
db: uniprot

Aspartokinase 1
type: ProteinReference
xref: uniprot Q04795 87
organism: Bacillus subtilis

uniprot Q8A1M5 135
type: UnificationXref
id: Q8A1M5
db: uniprot

uniprot Q949X7 41
type: UnificationXref
id: Q949X7
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__tetrahydrodipicolinate-_succinyl_CoA-RIGHT__H2O-_N_succinly_2_amino_6_oxopimelate-_CoA-_r5
controller: Tetrahydropyridine-2,6-dicarboxylate-N-succinyltransferase

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 3

Acetylornithine aminotransferase
type: ProteinReference
xref: uniprot Q9L1A4 124
organism: Streptomyces coelicolor

glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Aspartokinase 1, chloroplastic
type: ProteinReference
xref: uniprot Q9LYU8 100
organism: Arabidopsis thaliana

Acetylornithine aminotransferase, chloroplastic/mitochondrial
type: ProteinReference
xref: uniprot Q9M8M7 125
organism: Arabidopsis thaliana

Aspartokinase
type: ProteinReference
xref: uniprot P10869 83
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r2 164
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Aspartokinase
type: ProteinReference
xref: uniprot Q8F865 98
organism: Leptospira interrogans

Diaminopimelate epimerase
type: Protein
entity reference: Diaminopimelate epimerase
comment: SPECIES_TYPE=PROTEIN

AT1G14820 protein
type: ProteinReference
xref: uniprot B9DGS8 129
organism: Arabidopsis thaliana

uniprot P75682 54
type: UnificationXref
id: P75682
db: uniprot

Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic
type: ProteinReference
xref: uniprot Q9SA18 102
organism: Arabidopsis thaliana

STATE_TRANSITION_LEFT__LL_diaminopimelate-RIGHT__meso_diaminopimelate-_re11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 148
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 147
left: LL-diaminopimelate
interaction type: STATE_TRANSITION
right: meso-diaminopimelate

uniprot P23630 31
type: UnificationXref
id: P23630
db: uniprot

Putative dihydropicolinate synthase
type: ProteinReference
xref: uniprot Q93RY0 62
organism: Streptomyces coelicolor

uniprot P73133 118
type: UnificationXref
id: P73133
db: uniprot

PARTICIPANT STOICHIOMETRY r2 162
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 163
type: Stoichiometry
physical entity: aspartate semialdehyde
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 161
type: Stoichiometry
physical entity: aspartyl-phosphate
stoichiometric coefficient: 1.0

uniprot O80574 4
type: UnificationXref
id: O80574
db: uniprot

uniprot Q8ZV07 123
type: UnificationXref
id: Q8ZV07
db: uniprot

Bradyrhizobium diazoefficiens
type: BioSource
xref: ncbitaxon 224911 70

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 61

uniprot O86836 8
type: UnificationXref
id: O86836
db: uniprot

4-hydroxy-tetrahydrodipicolinate reductase
type: ProteinReference
xref: uniprot O67061 2
organism: Aquifex aeolicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_N_succinyl_diaminopimelate-RIGHT__succinate-_LL_diaminopimelate-_re10
controller: N-succinyl-diaminopimelate desuccinylase

Diaminopimelate decarboxylase
type: ProteinReference
xref: uniprot P19572 29
organism: Pseudomonas aeruginosa

uniprot P36839 117
type: UnificationXref
id: P36839
db: uniprot

uniprot Q04796 56
type: UnificationXref
id: Q04796
db: uniprot

Diaminopimelate decarboxylase
type: ProteinReference
xref: uniprot Q8TSR9 40
organism: Methanosarcina acetivorans

4-hydroxy-tetrahydrodipicolinate reductase
type: ProteinReference
xref: uniprot Q7NLC0 14
organism: Gloeobacter violaceus

uniprot O94671 80
type: UnificationXref
id: O94671
db: uniprot

L-lysine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 17

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 9

uniprot B7P667 48
type: UnificationXref
id: B7P667
db: uniprot

Os01g0926800 protein
type: ProteinReference
xref: uniprot Q8S1X5 136
organism: Oryza sativa

pyruvate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9HWJ3 65
type: UnificationXref
id: Q9HWJ3
db: uniprot

ncbitaxon 226186 19
type: UnificationXref
id: 226186
db: ncbitaxon

uniprot O67216 50
type: UnificationXref
id: O67216
db: uniprot

uniprot Q7UMB6 94
type: UnificationXref
id: Q7UMB6
db: uniprot

4-hydroxy-tetrahydrodipicolinate reductase 1, chloroplastic
type: ProteinReference
xref: uniprot O80574 4
organism: Arabidopsis thaliana

uniprot Q7NJQ8 92
type: UnificationXref
id: Q7NJQ8
db: uniprot

uniprot O30508 110
type: UnificationXref
id: O30508
db: uniprot

uniprot Q93RY0 62
type: UnificationXref
id: Q93RY0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9HWJ3 65
organism: Pseudomonas aeruginosa

Probable aspartokinase
type: ProteinReference
xref: uniprot O60163 76
organism: Schizosaccharomyces pombe

PARTICIPANT STOICHIOMETRY r4 149
type: Stoichiometry
physical entity: 2,3-dihydrodipicolinate
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

Diaminopimelate decarboxylase
type: ProteinReference
xref: uniprot O67262 28
organism: Aquifex aeolicus

STATE_TRANSITION_LEFT__tetrahydrodipicolinate-_succinyl_CoA-RIGHT__H2O-_N_succinly_2_amino_6_oxopimelate-_CoA-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 143
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 142
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 146
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 145
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 144
left: succinyl-CoA
left: tetrahydrodipicolinate
interaction type: STATE_TRANSITION
right: H2O
right: CoA
right: N-succinly-2-amino-6-oxopimelate

Acetylornithine aminotransferase
type: ProteinReference
xref: uniprot Q8TUE8 122
organism: Methanosarcina acetivorans

uniprot O67221 78
type: UnificationXref
id: O67221
db: uniprot

Aspartate semialdehyde dehydrogenase
type: Protein
entity reference: Aspartate semialdehyde dehydrogenase
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot Q75JL7 38
organism: Dictyostelium discoideum

Acetylornithine aminotransferase
type: ProteinReference
xref: uniprot P36839 117
organism: Bacillus subtilis

Diaminopimelate decarboxylase
type: ProteinReference
xref: uniprot P23630 31
organism: Bacillus subtilis

Probable dihydrodipicolinate synthetase
type: ProteinReference
xref: uniprot Q9I6R5 68
organism: Pseudomonas aeruginosa

uniprot Q8TUD6 99
type: UnificationXref
id: Q8TUD6
db: uniprot

uniprot Q9X1K9 71
type: UnificationXref
id: Q9X1K9
db: uniprot

4-hydroxy-tetrahydrodipicolinate reductase
type: ProteinReference
xref: uniprot Q9X1K8 26
organism: Thermotoga maritima

Diaminopimelate decarboxylase
type: ProteinReference
xref: uniprot Q9X1K5 46
organism: Thermotoga maritima

Aspartokinase
type: ProteinReference
xref: uniprot Q9X1K6 104
organism: Thermotoga maritima

Aspartate semialdehyde dehydrogenase
type: ProteinReference
xref: P03013
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Aspartate semialdehyde dehydrogenase Synonym: Synonym not specified Accession: P03013
comment: ENTITY_REFERENCE_ID_DESC=Lysine biosynthesis.PROTEIN.GENERIC.Aspartate semialdehyde_br_dehydrogenase
member entity reference: Aspartate-semialdehyde dehydrogenase
member entity reference: AT1G14820 protein
member entity reference: Polyphosphoinositide binding protein, putative
member entity reference: Os01g0926800 protein
member entity reference: USG-1 protein

4-hydroxy-tetrahydrodipicolinate synthase
type: ProteinReference
xref: uniprot Q9X1K9 71
organism: Thermotoga maritima

uniprot Q2QNF7 108
type: UnificationXref
id: Q2QNF7
db: uniprot

uniprot Q69LG7 90
type: UnificationXref
id: Q69LG7
db: uniprot

uniprot Q7NLV2 133
type: UnificationXref
id: Q7NLV2
db: uniprot

Polyphosphoinositide binding protein, putative
type: ProteinReference
xref: uniprot Q9LQ96 138
organism: Arabidopsis thaliana

uniprot O66442 113
type: UnificationXref
id: O66442
db: uniprot

Aspartokinase
type: ProteinReference
xref: uniprot Q8TUD6 99
organism: Methanosarcina acetivorans

Uncharacterized DapA-like lyase VNG_0444G
type: ProteinReference
xref: uniprot Q9HS19 63
organism: Halobacterium salinarum

uniprot F4K6Y8 74
type: UnificationXref
id: F4K6Y8
db: uniprot

STATE_TRANSITION_LEFT__meso_diaminopimelate-RIGHT__L_lysine-_CO2-_re12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 171
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 169
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 170
left: meso-diaminopimelate
interaction type: STATE_TRANSITION
right: L-lysine
right: CO2

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot Q9X1L1 140
organism: Thermotoga maritima

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__N_succinly_2_amino_6_oxopimelate-_glutamate-RIGHT__ketoglutarate-_N_succinyl_diaminopimelate-_r6
controller: N-succinyldiaminopimelate aminotransferase

uniprot Q94A94 42
type: UnificationXref
id: Q94A94
db: uniprot

Dihydrodipicolinate synthase, putative
type: ProteinReference
xref: uniprot B7P667 48
organism: Ixodes scapularis

uniprot Q75JL7 38
type: UnificationXref
id: Q75JL7
db: uniprot

2,3-dihydrodipicolinate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Acetylornithine aminotransferase
type: ProteinReference
xref: uniprot P24087 116
organism: Leptospira interrogans

uniprot Q9FJ82 25
type: UnificationXref
id: Q9FJ82
db: uniprot

Dihydrodipicolinate synthase
type: ProteinReference
xref: P03008
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Lysine biosynthesis.PROTEIN.GENERIC.Dihydrodipicolinate_br_synthase
comment: ENTITY_REFERENCE_NOTES= Long Name: Dihydrodipicolinate synthase Synonym: Synonym not specified Accession: P03008
member entity reference: 4-hydroxy-tetrahydrodipicolinate synthase
member entity reference: Uncharacterized protein
member entity reference: Probable dihydrodipicolinate synthetase
member entity reference: Probable 2-dehydro-3-deoxy-D-pentonate aldolase YjhH
member entity reference: Putative dihydropicolinate synthase
member entity reference: Uncharacterized DapA-like lyase VNG_0444G
member entity reference: Dihydrodipicolinate synthase, putative
member entity reference: 4-hydroxy-tetrahydrodipicolinate synthase 2
member entity reference: 4-hydroxy-tetrahydrodipicolinate synthase 1
member entity reference: Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE
member entity reference: Uncharacterized DapA-like lyase PAE2915

uniprot Q9X2A5 128
type: UnificationXref
id: Q9X2A5
db: uniprot

Dihydrodipicolinate reductase-like protein CRR1, chloroplastic
type: ProteinReference
xref: uniprot Q9FJ82 25
organism: Arabidopsis thaliana

uniprot Q04797 132
type: UnificationXref
id: Q04797
db: uniprot

Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE
type: ProteinReference
xref: uniprot P75682 54
organism: Escherichia coli

4-hydroxy-tetrahydrodipicolinate synthase
type: ProteinReference
xref: uniprot Q55513 57
organism: Synechocystis

uniprot P08660 82
type: UnificationXref
id: P08660
db: uniprot

uniprot Q9M8M7 125
type: UnificationXref
id: Q9M8M7
db: uniprot

Aspartate-semialdehyde dehydrogenase
type: ProteinReference
xref: uniprot Q8A1M5 135
organism: Bacteroides thetaiotaomicron

uniprot O67716 130
type: UnificationXref
id: O67716
db: uniprot

uniprot Q9RW75 127
type: UnificationXref
id: Q9RW75
db: uniprot

4-hydroxy-tetrahydrodipicolinate synthase
type: ProteinReference
xref: uniprot Q8THP1 59
organism: Methanosarcina acetivorans

4-hydroxy-tetrahydrodipicolinate reductase
type: ProteinReference
xref: uniprot Q8THP0 23
organism: Methanosarcina acetivorans

ncbitaxon 224308 13
type: UnificationXref
id: 224308
db: ncbitaxon

STATE_TRANSITION_LEFT__ATP-_L_aspartate-RIGHT__aspartyl_phosphate-_ADP-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 165
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 166
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 168
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 167
left: ATP
left: L-aspartate
interaction type: STATE_TRANSITION
right: ADP
right: aspartyl-phosphate

ncbitaxon 83333 11
type: UnificationXref
id: 83333
db: ncbitaxon

Aspartokinase
type: ProteinReference
xref: P03009
comment: ENTITY_REFERENCE_ID_DESC=Lysine biosynthesis.PROTEIN.GENERIC.Aspartokinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Aspartokinase Synonym: Synonym not specified Accession: P03009
member entity reference: Aspartokinase
member entity reference: Aspartokinase II
member entity reference: Lysine-sensitive aspartokinase 3
member entity reference: Aspartokinase 3
member entity reference: Homoserine dehydrogenase
member entity reference: Aspartate kinase-homoserine dehydrogenase
member entity reference: Aspartokinase/homoserine dehydrogenase
member entity reference: Aspartokinase 1, chloroplastic
member entity reference: Aspartate kinase
member entity reference: Aspartokinase 2
member entity reference: Probable aspartokinase
member entity reference: Lysine-sensitive aspartokinase III
member entity reference: Probable homoserine dehydrogenase
member entity reference: Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic
member entity reference: Aspartokinase 1
member entity reference: Aspartokinase 2, chloroplastic

uniprot O60163 76
type: UnificationXref
id: O60163
db: uniprot

PARTICIPANT STOICHIOMETRY r4 150
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Diaminopimelate epimerase
type: ProteinReference
xref: uniprot B8DZX7 106
organism: Dictyoglomus turgidum

uniprot P39359 53
type: UnificationXref
id: P39359
db: uniprot

STATE_TRANSITION_LEFT__pyruvate-_aspartate_semialdehyde_-RIGHT__2_H2O-_2,3_dihydrodipicolinate-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 158
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 159
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 157
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 160
left: aspartate semialdehyde
left: pyruvate
interaction type: STATE_TRANSITION
right: 2,3-dihydrodipicolinate
right: 2 H2O

ncbitaxon 559292 84
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot P94417 86
type: UnificationXref
id: P94417
db: uniprot

uniprot Q8AAB7 109
type: UnificationXref
id: Q8AAB7
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 91

PARTICIPANT STOICHIOMETRY r4 151
type: Stoichiometry
physical entity: tetrahydrodipicolinate
stoichiometric coefficient: 1.0

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 30

uniprot P04036 10
type: UnificationXref
id: P04036
db: uniprot

PARTICIPANT STOICHIOMETRY r4 152
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

tetrahydrodipicolinate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P9WIU7 32
type: UnificationXref
id: P9WIU7
db: uniprot

By Homology
type: RelationshipTypeVocabulary