uniprot O62609 59
type: UnificationXref
id: O62609
db: uniprot

GO GO:0005783 6
type: UnificationXref
id: GO:0005783
db: GO

PARTICIPANT STOICHIOMETRY re10 192
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re10 191
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

myoglianin s5 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s85 sa57 115
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re20 209
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 4

BABO s35 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__SMOX-_MED-RIGHT__SMOX-_phosphoSMOX__MED-_re17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 160
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 161
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 159
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 162
left: MED
left: SMOX
interaction type: STATE_TRANSITION
right: SMOX
right: phosphoSMOX/ MED

BABO s35 sa21 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

myoglianin s74 sa56 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

myoglianin s55 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

myoglianin s74 sa56 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.08
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re20 210
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

myoglianin s74 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

HOMODIMER ID 21STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

SMOX s40 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 190
type: Stoichiometry
physical entity: SARA/SMOX
stoichiometric coefficient: 1.0

SMOX s47 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 189
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

SMOX s98 sa71 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re11 188
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

uniprot Q9V853 48
type: UnificationXref
id: Q9V853
db: uniprot

early endosome
type: CellularLocationVocabulary
xref: GO GO:0005769 5

BABO s58 sa29 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 8

SARA
type: Protein
entity reference: SARA
feature: COMPLEX PARTICIPANT BINDING FEATURE s39 sa25 139
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

BABO s6 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

SMOX s98 sa71 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.08
comment: MODIFICATION_RESIDUE_NAME=

Evidence 35
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0086361.html

Evidence 38
type: Evidence
evidence code: IEA
comment: Website http://www.reactome.org/

Evidence 37
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0011300.html

?
type: Protein

HOMODIMER ID 24STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

PTHR47992:SF25
type: RelationshipXref
id: PTHR47992:SF25
db: PANTHER Family
relationship type: By Homology

SMOX s57 sa31 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.08
comment: MODIFICATION_RESIDUE_NAME=

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 51
xref: PTHR13703:SF25
xref: uniprot O96660 50
organism: Drosophila melanogaster

DISSOCIATION_LEFT__proMyoglianin-RIGHT__myoglianin-_?-_re6
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 149
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 150
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 148
left: proMyoglianin
interaction type: DISSOCIATION
right: myoglianin
right: ?

? s31 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

Evidence 49
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0029006.html

BABO s65 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PTHR13703:SF45
type: RelationshipXref
id: PTHR13703:SF45
db: PANTHER Family
relationship type: By Homology

HOMODIMER ID 26STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

SMOX s57 sa31 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q961C5 33
type: UnificationXref
id: Q961C5
db: uniprot

myoglianin
type: Protein
entity reference: myoglianin

MED
type: Protein
entity reference: MED
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Evidence 55
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0026369.html

?
type: Protein

Evidence 51
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBrf0190369.html

Evidence 60
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0011655.html

PARTICIPANT STOICHIOMETRY re12 187
type: Stoichiometry
physical entity: WIT/myoglianin phosphoBABO SARA/SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re12 186
type: Stoichiometry
physical entity: SARA/SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re12 185
type: Stoichiometry
physical entity: WIT/myoglianin phosphoBABO
stoichiometric coefficient: 1.0

WIT/myoglianin phosphoBABO SARA/SMOX
type: Complex
component stoichiometry: SARA s56 sa30 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 29STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 19STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 44STOICHIOMETRY ID COMPLEX
component stoichiometry: SMOX s57 sa31 STOICHIOMETRY ID COMPLEX
component: SARA
component: BABO
component: WIT
component: SMOX
component: myoglianin
feature: COMPLEX BINDING FEATURE s68 csa7 80
feature: COMPLEX BINDING FEATURE s68 csa7 82
feature: COMPLEX BINDING FEATURE s68 csa7 86
feature: COMPLEX BINDING FEATURE s68 csa7 88
feature: COMPLEX BINDING FEATURE s68 csa7 84
cellular location: cytosol

WIT
type: Protein
entity reference: WIT

WIT
type: Protein
entity reference: WIT

WIT
type: Protein
entity reference: WIT

WIT/myoglianin
type: Complex
component stoichiometry: HOMODIMER ID 23STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 15STOICHIOMETRY ID COMPLEX
component: myoglianin
component: WIT
feature: COMPLEX BINDING FEATURE s3 csa1 62
feature: COMPLEX BINDING FEATURE s3 csa1 64
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re3 163
type: Stoichiometry
physical entity: WIT/myoglianin BABO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 164
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 10.0

Golgi apparatus
type: CellularLocationVocabulary
xref: GO GO:0005794 2

uniprot A1Z7L8 36
type: UnificationXref
id: A1Z7L8
db: uniprot

STATE_TRANSITION_LEFT__WIT_myoglianin_phosphoBABO_SARA_SMOX-_ATP-RIGHT__WIT_myoglianin_phosphoBABO_SARA__phosphoSMOX-_ADP-_re14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 181
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 179
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 182
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 180
left: ATP
left: WIT/myoglianin phosphoBABO SARA/SMOX
interaction type: STATE_TRANSITION
right: WIT/myoglianin phosphoBABO SARA/ phosphoSMOX
right: ADP

myoglianin
type: Protein
entity reference: myoglianin

PARTICIPANT STOICHIOMETRY re3 166
type: Stoichiometry
physical entity: WIT/myoglianin phosphoBABO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 165
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 10.0

GO GO:0005829 3
type: UnificationXref
id: GO:0005829
db: GO

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s91 sa65 119
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__BABO-RIGHT__BABO-_re8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 144
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 145
left: BABO
interaction type: STATE_TRANSITION
right: BABO

HOMODIMER ID 42STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

TRANSPORT_LEFT__SMOX-RIGHT__SMOX-_re22
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 206
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 205
left: SMOX
interaction type: TRANSPORT
right: SMOX

TRANSPORT_LEFT__SMOX-RIGHT__SMOX-_re23
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 204
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 203
left: SMOX
interaction type: TRANSPORT
right: SMOX

SMOX s101 sa73 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PPM1A
type: ProteinReference
xref: P06317
standard name: protein phosphatase 2C alpha, beta
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=MYO_signaling_pathway.PROTEIN.GENERIC.PPM1A
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Alphabet, isoform E

WIT
type: Protein
entity reference: WIT
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF63
xref: uniprot M9PE88 12
organism: Drosophila melanogaster

LACK s97 sa70 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 6

TRUNCATION
type: RelationshipTypeVocabulary

SMOX s57 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

DISSOCIATION_LEFT__phosphoSMOX__MED-RIGHT__MED-_SMOX-_re19
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 151
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 152
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 153
left: phosphoSMOX/ MED
interaction type: DISSOCIATION
right: MED
right: SMOX

PARTICIPANT STOICHIOMETRY re9 143
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re22 206
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re26 196
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re9 142
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re22 205
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re26 197
type: Stoichiometry
physical entity: sa76_degraded
stoichiometric coefficient: 1.0

PTHR13703:SF25
type: RelationshipXref
id: PTHR13703:SF25
db: PANTHER Family
relationship type: By Homology

HOMODIMER ID 23STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

proMyoglianin
type: Complex
component stoichiometry: HOMODIMER ID 26STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 57STOICHIOMETRY ID COMPLEX
component: ?
component: myoglianin
feature: COMPLEX BINDING FEATURE s29 csa4 124
feature: COMPLEX BINDING FEATURE s29 csa4 126
cellular location: Golgi apparatus

WIT s59 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s90 sa64 rs2
feature: SMOX s90 sa64 rs1

LACK
type: Protein
entity reference: LACK
feature: COMPLEX PARTICIPANT BINDING FEATURE s97 sa70 73
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s102 sa68 rs1
feature: SMOX s102 sa68 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s76 sa49 rs2
feature: SMOX s76 sa49 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s98 sa71 rs2
feature: SMOX s98 sa71 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s98 sa71 75
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

BABO s14 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

SMOX
type: Protein
entity reference: SMOX
feature: COMPLEX PARTICIPANT BINDING FEATURE s47 sa36 95
feature: SMOX s47 sa36 rs1
feature: SMOX s47 sa36 rs2
cellular location: early endosome
comment: SPECIES_TYPE=PROTEIN

WIT
type: Protein
entity reference: WIT

PARTICIPANT STOICHIOMETRY re1 176
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re1 177
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

HOMODIMER ID 15STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

BABO
type: Protein
entity reference: BABO
feature: BABO s6 sa3 rs1

00696
type: UnificationXref
id: MOD:00696
db: mod

phosphoSMOX LACK
type: Complex
component stoichiometry: SMOX s98 sa71 STOICHIOMETRY ID COMPLEX
component stoichiometry: LACK s97 sa70 STOICHIOMETRY ID COMPLEX
component: SMOX
component: LACK
feature: COMPLEX BINDING FEATURE s96 csa13 74
feature: COMPLEX BINDING FEATURE s96 csa13 72
cellular location: cytosol

HOMODIMER ID 57STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re25 198
type: Stoichiometry
physical entity: phosphoSMOX LACK
stoichiometric coefficient: 1.0

BABO s58 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re25 199
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 156
type: Stoichiometry
physical entity: myoglianin full length
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re4 158
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 34

PARTICIPANT STOICHIOMETRY re4 157
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re5 154
type: Stoichiometry
physical entity: proMyoglianin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 178
type: Stoichiometry
physical entity: WIT/myoglianin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 155
type: Stoichiometry
physical entity: proMyoglianin
stoichiometric coefficient: 1.0

WIT/myoglianin phosphoBABO SARA/SMOX
type: Complex
component stoichiometry: HOMODIMER ID 18STOICHIOMETRY ID COMPLEX
component stoichiometry: SMOX s47 sa36 STOICHIOMETRY ID COMPLEX
component stoichiometry: SARA s46 sa35 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 28STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 43STOICHIOMETRY ID COMPLEX
component: SMOX
component: WIT
component: BABO
component: myoglianin
component: SARA
feature: COMPLEX BINDING FEATURE s69 csa8 98
feature: COMPLEX BINDING FEATURE s69 csa8 94
feature: COMPLEX BINDING FEATURE s69 csa8 92
feature: COMPLEX BINDING FEATURE s69 csa8 90
feature: COMPLEX BINDING FEATURE s69 csa8 96
cellular location: early endosome

TRANSPORT_LEFT__phosphoSMOX__MED-RIGHT__phosphoSMOX__MED-_re21
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 207
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 208
left: phosphoSMOX/ MED
interaction type: TRANSPORT
right: phosphoSMOX/ MED

HOMODIMER ID 32STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

SARA/SMOX
type: Complex
component stoichiometry: SARA s39 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: SMOX s40 sa26 STOICHIOMETRY ID COMPLEX
component: SMOX
component: SARA
feature: COMPLEX BINDING FEATURE s38 csa6 140
feature: COMPLEX BINDING FEATURE s38 csa6 138
cellular location: cytosol

SMOX s76 sa49 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.08
comment: MODIFICATION_RESIDUE_NAME=

WIT s4 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__WIT-RIGHT__WIT-_re7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 147
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 146
left: WIT
interaction type: STATE_TRANSITION
right: WIT

SMOX s101 sa73 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

BABO s14 sa8 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

DISSOCIATION
type: RelationshipTypeVocabulary

WIT
type: Protein
entity reference: WIT

PARTICIPANT STOICHIOMETRY re6 148
type: Stoichiometry
physical entity: proMyoglianin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re6 149
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

HOMODIMER ID 18STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

SMOX s76 sa49 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

WIT
type: ProteinReference
xref: P06316
standard name: wishful thinking
comment: ENTITY_REFERENCE_ID_DESC=MYO_signaling_pathway.PROTEIN.RECEPTOR.WIT
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Receptor protein serine/threonine kinase

SMOX s101 sa73 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.08
comment: MODIFICATION_RESIDUE_NAME=

WIT s33 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re6 150
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re13 184
type: Stoichiometry
physical entity: WIT/myoglianin phosphoBABO SARA/SMOX
stoichiometric coefficient: 1.0

Protein mothers against dpp
type: ProteinReference
xref: uniprot P42003 61
organism: Drosophila melanogaster

HOMODIMER ID 17STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re13 183
type: Stoichiometry
physical entity: WIT/myoglianin phosphoBABO SARA/SMOX
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__proMyoglianin-RIGHT__proMyoglianin-_re5
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 154
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 155
left: proMyoglianin
interaction type: TRANSPORT
right: proMyoglianin

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s67 sa43 rs1
feature: SMOX s67 sa43 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s67 sa43 133
cellular location: early endosome
comment: SPECIES_TYPE=PROTEIN

eco ECO:0000501 34
type: UnificationXref
id: ECO:0000501
db: eco

PTHR11848:SF262
type: RelationshipXref
id: PTHR11848:SF262
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phosphoSMOX_LACK-RIGHT__phosphoSMOX_LACK-_re24
controller: LACK

MED s85 sa57 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__SMOX-_LACK-RIGHT__phosphoSMOX_LACK-_re27
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 195
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 193
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 194
left: LACK
left: SMOX
interaction type: HETERODIMER_ASSOCIATION
right: phosphoSMOX LACK

Receptor protein serine/threonine kinase
type: ProteinReference
evidence: Evidence 37
evidence: Evidence 38
xref: PTHR23255:SF71
xref: uniprot A1Z7L8 36
organism: Drosophila melanogaster

myoglianin s44 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__WIT_myoglianin_phosphoBABO_SARA_SMOX-_ATP-RIGHT__WIT_myoglianin_phosphoBABO_SARA__phosphoSMOX-_ADP-_re14
controller: BABO

proMyoglianin
type: Complex
component stoichiometry: HOMODIMER ID 25STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 58STOICHIOMETRY ID COMPLEX
component: ?
component: myoglianin
feature: COMPLEX BINDING FEATURE s26 csa5 120
feature: COMPLEX BINDING FEATURE s26 csa5 122

STATE_TRANSITION
type: RelationshipTypeVocabulary

myoglianin s63 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

BABO
type: Protein
entity reference: BABO
feature: BABO s65 sa44 rs1

HOMODIMER ID 45STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

SARA s56 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

LACK
type: Protein
entity reference: LACK
feature: COMPLEX PARTICIPANT BINDING FEATURE s100 sa72 77
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

BABO
type: Protein
entity reference: BABO
feature: BABO s75 sa11 rs1

? s32 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re15 175
type: Stoichiometry
physical entity: WIT/myoglianin phosphoBABO
stoichiometric coefficient: 1.0

P06310
type: UnificationXref
id: P06310
db: PANTHER Pathway Component

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 60
xref: uniprot O62609 59
xref: PTHR13703:SF45
organism: Drosophila melanogaster

P06311
type: UnificationXref
id: P06311
db: PANTHER Pathway Component

P06312
type: UnificationXref
id: P06312
db: PANTHER Pathway Component

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s57 sa31 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s57 sa31 89
feature: SMOX s57 sa31 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

myoglianin
type: Protein
entity reference: myoglianin

P06313
type: UnificationXref
id: P06313
db: PANTHER Pathway Component

P06314
type: UnificationXref
id: P06314
db: PANTHER Pathway Component

P06315
type: UnificationXref
id: P06315
db: PANTHER Pathway Component

P06316
type: UnificationXref
id: P06316
db: PANTHER Pathway Component

FUR1
type: Protein
entity reference: FUR1
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

P06317
type: UnificationXref
id: P06317
db: PANTHER Pathway Component

uniprot P42003 61
type: UnificationXref
id: P42003
db: uniprot

HOMODIMER ID 20STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re15 172
type: Stoichiometry
physical entity: WIT/myoglianin phosphoBABO SARA/ phosphoSMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re15 173
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re15 174
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

SMOX s79 sa54 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.08
comment: MODIFICATION_RESIDUE_NAME=

BABO
type: ProteinReference
xref: P06310
standard name: baboon
comment: ENTITY_REFERENCE_ID_DESC=MYO_signaling_pathway.PROTEIN.RECEPTOR.BABO
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Receptor protein serine/threonine kinase

LD29161p
type: ProteinReference
xref: uniprot Q9V4F4 7
xref: PTHR11848:SF262
organism: Drosophila melanogaster

myoglianin full length
type: ProteinReference
xref: P06315
standard name: myoglianin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=MYO_signaling_pathway.PROTEIN.GENERIC.myoglianin_br_full length
comment: ENTITY_REFERENCE_NOTES=
member entity reference: LD29161p

IDA
type: EvidenceCodeVocabulary

P06309
type: UnificationXref
id: P06309
db: PANTHER Pathway Component

BABO s75 sa11 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

SMOX s79 sa54 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

HETERODIMER_ASSOCIATION_LEFT__WIT_myoglianin_phosphoBABO-_SARA_SMOX-RIGHT__WIT_myoglianin_phosphoBABO_SARA_SMOX-_re12
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 187
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 185
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 186
left: WIT/myoglianin phosphoBABO
left: SARA/SMOX
interaction type: HETERODIMER_ASSOCIATION
right: WIT/myoglianin phosphoBABO SARA/SMOX

?
type: Protein

HETERODIMER_ASSOCIATION_LEFT__myoglianin-_WIT-RIGHT__WIT_myoglianin-_re1
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 176
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 177
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 178
left: WIT
left: myoglianin
interaction type: HETERODIMER_ASSOCIATION
right: WIT/myoglianin

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s94 sa50 rs2
feature: SMOX s94 sa50 rs1
cellular location: early endosome
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__MED-RIGHT__MED-_re20
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 209
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 210
left: MED
interaction type: TRANSPORT
right: MED

sa76_degraded
type: PhysicalEntity
cellular location: cytosol
comment: SPECIES_TYPE=DEGRADED

SARA
type: Protein
entity reference: SARA
feature: COMPLEX PARTICIPANT BINDING FEATURE s64 sa42 131
cellular location: early endosome
comment: SPECIES_TYPE=PROTEIN

P06318
type: UnificationXref
id: P06318
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__myoglianin_full_length-RIGHT__myoglianin-_?-_re4
controller: FUR1

?
type: Complex
component stoichiometry: ? s32 sa18 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa18 123

?
type: Complex
component stoichiometry: ? s31 sa16 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa16 127
cellular location: Golgi apparatus

uniprot M9PE88 12
type: UnificationXref
id: M9PE88
db: uniprot

PTHR11254:SF395
type: RelationshipXref
id: PTHR11254:SF395
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re8 145
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re8 144
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 1.0

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s40 sa26 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s40 sa26 141
feature: SMOX s40 sa26 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re21 207
type: Stoichiometry
physical entity: phosphoSMOX/ MED
stoichiometric coefficient: 1.0

DISSOCIATION_LEFT__WIT_myoglianin_phosphoBABO_SARA__phosphoSMOX-RIGHT__SMOX-_SMOX-_WIT_myoglianin_phosphoBABO-_re15
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 174
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 172
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 175
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 173
left: WIT/myoglianin phosphoBABO SARA/ phosphoSMOX
interaction type: DISSOCIATION
right: SMOX
right: WIT/myoglianin phosphoBABO

TRANSPORT
type: RelationshipTypeVocabulary

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__WIT_myoglianin_BABO-_ATP-RIGHT__ADP-_WIT_myoglianin_phosphoBABO-_re3
controller: WIT

HETERODIMER_ASSOCIATION_LEFT__BABO-_WIT_myoglianin-RIGHT__WIT_myoglianin_BABO-_re2
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 171
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 169
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 170
left: BABO
left: WIT/myoglianin
interaction type: HETERODIMER_ASSOCIATION
right: WIT/myoglianin BABO

PARTICIPANT STOICHIOMETRY re21 208
type: Stoichiometry
physical entity: phosphoSMOX/ MED
stoichiometric coefficient: 1.0

myoglianin
type: Protein
entity reference: myoglianin

BABO
type: Protein
entity reference: BABO
feature: BABO s36 sa22 rs1
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

myoglianin s50 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

? s25 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

BABO s6 sa3 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

ncbitaxon 7227 8
type: UnificationXref
id: 7227
db: ncbitaxon

SARA s46 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

HOMODIMER ID 30STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

Target transcripts
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

PARTICIPANT STOICHIOMETRY re25 200
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

FUR1
type: ProteinReference
xref: P06318
standard name: furin 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=MYO_signaling_pathway.PROTEIN.GENERIC.FUR1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Furin-like protease 1, isoforms 1/1-X/2

PARTICIPANT STOICHIOMETRY re14 179
type: Stoichiometry
physical entity: WIT/myoglianin phosphoBABO SARA/SMOX
stoichiometric coefficient: 1.0

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

SMOX s102 sa68 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.08
comment: MODIFICATION_RESIDUE_NAME=

SMOX s40 sa26 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.08
comment: MODIFICATION_RESIDUE_NAME=

myoglianin
type: Protein
entity reference: myoglianin

STATE_TRANSITION_LEFT__phosphoSMOX_LACK-RIGHT__phosphoSMOX_LACK-_re24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 201
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 202
left: phosphoSMOX LACK
interaction type: STATE_TRANSITION
right: phosphoSMOX LACK

BABO
type: Complex
component stoichiometry: BABO s6 sa3 STOICHIOMETRY ID COMPLEX
component: BABO
cellular location: cytosol

WIT/myoglianin BABO
type: Complex
component stoichiometry: HOMODIMER ID 41STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 16STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 24STOICHIOMETRY ID COMPLEX
component: myoglianin
component: WIT
component: BABO
feature: COMPLEX BINDING FEATURE s7 csa2 70
feature: COMPLEX BINDING FEATURE s7 csa2 68
feature: COMPLEX BINDING FEATURE s7 csa2 66
cellular location: cytosol

SMOX
type: ProteinReference
xref: P06314
standard name: Smad on X
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=MYO_signaling_pathway.PROTEIN.GENERIC.SMOX
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mothers against decapentaplegic homolog

uniprot Q7K9H6 54
type: UnificationXref
id: Q7K9H6
db: uniprot

SMOX s98 sa71 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

BABO s45 sa48 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

myoglianin
type: Protein
entity reference: myoglianin
feature: myoglianin s74 sa56 rs2
feature: myoglianin s74 sa56 rs1

BABO
type: Complex
component stoichiometry: BABO s35 sa21 STOICHIOMETRY ID COMPLEX
component: BABO
cellular location: endoplasmic reticulum

BABO
type: Complex
component stoichiometry: BABO s14 sa8 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa8 71
cellular location: cytosol

HOMODIMER ID 53STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 2.0

BABO
type: Complex
component stoichiometry: BABO s58 sa29 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s58 sa29 85
cellular location: cytosol

BABO
type: Complex
component stoichiometry: BABO s65 sa44 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s65 sa44 135
cellular location: early endosome

BABO
type: Complex
component stoichiometry: BABO s45 sa48 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa48 111
cellular location: early endosome

HOMODIMER ID 25STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

BABO
type: Complex
component stoichiometry: BABO s51 sa37 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s51 sa37 97
cellular location: early endosome

myoglianin
type: Protein
entity reference: myoglianin

BABO
type: Complex
component stoichiometry: BABO s75 sa11 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s75 sa11 105
cellular location: cytosol

phosphoSMOX/ MED
type: Complex
component stoichiometry: HOMODIMER ID 53STOICHIOMETRY ID COMPLEX
component stoichiometry: MED s91 sa65 STOICHIOMETRY ID COMPLEX
component: SMOX
component: MED
feature: COMPLEX BINDING FEATURE s89 csa12 116
feature: COMPLEX BINDING FEATURE s89 csa12 118
cellular location: nucleus

BABO s36 sa22 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

BABO s75 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

SMOX s40 sa26 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re24 201
type: Stoichiometry
physical entity: phosphoSMOX LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re14 180
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re24 202
type: Stoichiometry
physical entity: phosphoSMOX LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re14 182
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re14 181
type: Stoichiometry
physical entity: WIT/myoglianin phosphoBABO SARA/ phosphoSMOX
stoichiometric coefficient: 1.0

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

SMOX
type: Complex
component stoichiometry: SMOX s79 sa54 STOICHIOMETRY ID COMPLEX
component: SMOX
cellular location: cytosol

SMOX
type: Complex
component stoichiometry: SMOX s90 sa64 STOICHIOMETRY ID COMPLEX
component: SMOX
feature: COMPLEX PARTICIPANT BINDING FEATURE s90 sa64 117
cellular location: nucleus

WIT s73 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

?
type: Complex
component stoichiometry: ? s25 sa14 STOICHIOMETRY ID COMPLEX
component: ?

HOMODIMER ID 27STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re17 162
type: Stoichiometry
physical entity: phosphoSMOX/ MED
stoichiometric coefficient: 1.0

PTHR23255:SF63
type: RelationshipXref
id: PTHR23255:SF63
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re23 203
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

WIT
type: Complex
component stoichiometry: WIT s59 sa27 STOICHIOMETRY ID COMPLEX
component: WIT
feature: COMPLEX PARTICIPANT BINDING FEATURE s59 sa27 81
cellular location: cytosol

MED s91 sa65 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

SARA
type: Protein
entity reference: SARA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

WIT
type: Complex
component stoichiometry: WIT s43 sa46 STOICHIOMETRY ID COMPLEX
component: WIT
feature: COMPLEX PARTICIPANT BINDING FEATURE s43 sa46 107
cellular location: early endosome

WIT
type: Complex
component stoichiometry: WIT s49 sa38 STOICHIOMETRY ID COMPLEX
component: WIT
feature: COMPLEX PARTICIPANT BINDING FEATURE s49 sa38 99
cellular location: early endosome

PARTICIPANT STOICHIOMETRY re17 161
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

WIT
type: Complex
component stoichiometry: WIT s4 sa4 STOICHIOMETRY ID COMPLEX
component: WIT
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa4 63
cellular location: cytosol

HOMODIMER ID 19STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re17 160
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

BABO
type: Protein
entity reference: BABO
feature: BABO s45 sa48 rs1

WIT
type: Complex
component stoichiometry: WIT s12 sa6 STOICHIOMETRY ID COMPLEX
component: WIT
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa6 67
cellular location: cytosol

WIT
type: Complex
component stoichiometry: WIT s2 sa2 STOICHIOMETRY ID COMPLEX
component: WIT
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re23 204
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

WIT
type: Complex
component stoichiometry: WIT s33 sa19 STOICHIOMETRY ID COMPLEX
component: WIT
cellular location: endoplasmic reticulum

myoglianin
type: Complex
component stoichiometry: myoglianin s5 sa5 STOICHIOMETRY ID COMPLEX
component: myoglianin
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa5 65
cellular location: cytosol

myoglianin
type: Complex
component stoichiometry: myoglianin s1 sa1 STOICHIOMETRY ID COMPLEX
component: myoglianin

WIT
type: Complex
component stoichiometry: WIT s73 sa9 STOICHIOMETRY ID COMPLEX
component: WIT
feature: COMPLEX PARTICIPANT BINDING FEATURE s73 sa9 101
cellular location: cytosol

WIT
type: Complex
component stoichiometry: WIT s66 sa45 STOICHIOMETRY ID COMPLEX
component: WIT
feature: COMPLEX PARTICIPANT BINDING FEATURE s66 sa45 137
cellular location: early endosome

SARA
type: ProteinReference
xref: P06313
standard name: Smad anchor for receptor activation
comment: ENTITY_REFERENCE_ID_DESC=MYO_signaling_pathway.PROTEIN.RECEPTOR.SARA
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Zinc finger FYVE domain-containing protein

HOMODIMER ID 58STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PTHR23255:SF71
type: RelationshipXref
id: PTHR23255:SF71
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

STATE_TRANSITION_LEFT__WIT_myoglianin_BABO-_ATP-RIGHT__ADP-_WIT_myoglianin_phosphoBABO-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 165
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 164
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 163
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 166
left: ATP
left: WIT/myoglianin BABO
interaction type: STATE_TRANSITION
right: WIT/myoglianin phosphoBABO
right: ADP

myoglianin
type: Complex
component stoichiometry: myoglianin s50 sa34 STOICHIOMETRY ID COMPLEX
component: myoglianin
feature: COMPLEX PARTICIPANT BINDING FEATURE s50 sa34 91
cellular location: early endosome

TRANSPORT_LEFT__WIT-RIGHT__WIT-_re10
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 191
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 192
left: WIT
interaction type: TRANSPORT
right: WIT

myoglianin
type: Complex
component stoichiometry: myoglianin s55 sa28 STOICHIOMETRY ID COMPLEX
component: myoglianin
feature: COMPLEX PARTICIPANT BINDING FEATURE s55 sa28 83
cellular location: cytosol

SMOX s90 sa64 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

myoglianin
type: Complex
component stoichiometry: myoglianin s13 sa7 STOICHIOMETRY ID COMPLEX
component: myoglianin
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa7 69
cellular location: cytosol

myoglianin
type: Complex
component stoichiometry: myoglianin s27 sa17 STOICHIOMETRY ID COMPLEX
component: myoglianin
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa17 121

myoglianin
type: Complex
component stoichiometry: myoglianin s30 sa15 STOICHIOMETRY ID COMPLEX
component: myoglianin
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa15 125
cellular location: Golgi apparatus

SMOX s102 sa68 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

myoglianin
type: Complex
component stoichiometry: myoglianin s44 sa47 STOICHIOMETRY ID COMPLEX
component: myoglianin
feature: COMPLEX PARTICIPANT BINDING FEATURE s44 sa47 109
cellular location: early endosome

myoglianin
type: Complex
component stoichiometry: myoglianin s74 sa56 STOICHIOMETRY ID COMPLEX
component: myoglianin
feature: COMPLEX PARTICIPANT BINDING FEATURE s74 sa56 113
cellular location: cytosol

myoglianin
type: Complex
component stoichiometry: myoglianin s84 sa10 STOICHIOMETRY ID COMPLEX
component: myoglianin
feature: COMPLEX PARTICIPANT BINDING FEATURE s84 sa10 103
cellular location: cytosol

myoglianin
type: Complex
component stoichiometry: myoglianin s63 sa41 STOICHIOMETRY ID COMPLEX
component: myoglianin
feature: COMPLEX PARTICIPANT BINDING FEATURE s63 sa41 129
cellular location: early endosome

PARTICIPANT STOICHIOMETRY re17 159
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 3.0

BABO
type: Protein
entity reference: BABO
feature: BABO s51 sa37 rs1

myoglianin
type: Protein
entity reference: myoglianin

PARTICIPANT STOICHIOMETRY re19 153
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PTHR42884:SF3
type: RelationshipXref
id: PTHR42884:SF3
db: PANTHER Family
relationship type: By Homology

GO GO:0005769 5
type: UnificationXref
id: GO:0005769
db: GO

PARTICIPANT STOICHIOMETRY re19 151
type: Stoichiometry
physical entity: phosphoSMOX/ MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 152
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__WIT_myoglianin_phosphoBABO_SARA_SMOX-RIGHT__WIT_myoglianin_phosphoBABO_SARA_SMOX-_re13
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 184
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 183
left: WIT/myoglianin phosphoBABO SARA/SMOX
interaction type: TRANSPORT
right: WIT/myoglianin phosphoBABO SARA/SMOX

SMOX s90 sa64 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.08
comment: MODIFICATION_RESIDUE_NAME=

WIT s43 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

WIT s66 sa45 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

HOMODIMER ID 41STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

SMOX s94 sa50 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SMOX s67 sa43 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.08
comment: MODIFICATION_RESIDUE_NAME=

HOMODIMER ID 29STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

myoglianin
type: Protein
entity reference: myoglianin

myoglianin s13 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

TRUNCATION_LEFT__myoglianin_full_length-RIGHT__myoglianin-_?-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 158
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 156
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 157
left: myoglianin full length
interaction type: TRUNCATION
right: ?
right: myoglianin

PPM1A
type: Protein
entity reference: PPM1A
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

myoglianin
type: Protein
entity reference: myoglianin

HETERODIMER_ASSOCIATION_LEFT__SARA-_SMOX-RIGHT__SARA_SMOX-_re11
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 189
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 190
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 188
left: SMOX
left: SARA
interaction type: HETERODIMER_ASSOCIATION
right: SARA/SMOX

HOMODIMER ID 16STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

WIT s12 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

myoglianin full length s20 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin full length
stoichiometric coefficient: 2.0

LACK
type: ProteinReference
xref: P06309
standard name: lethal with a checkpoint kinase
comment: ENTITY_REFERENCE_ID_DESC=MYO_signaling_pathway.PROTEIN.GENERIC.LACK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: E3 ubiquitin-protein ligase Smurf1

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s79 sa54 rs2
feature: SMOX s79 sa54 rs1

myoglianin full length
type: Complex
component stoichiometry: myoglianin full length s20 sa12 STOICHIOMETRY ID COMPLEX
component: myoglianin full length
cellular location: Golgi apparatus

SMOX s67 sa43 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

HOMODIMER ID 44STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

SARA
type: Protein
entity reference: SARA
feature: COMPLEX PARTICIPANT BINDING FEATURE s46 sa35 93
cellular location: early endosome
comment: SPECIES_TYPE=PROTEIN

SMOX s94 sa50 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.08
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re27 195
type: Stoichiometry
physical entity: phosphoSMOX LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re27 194
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re27 193
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

BABO s65 sa44 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

SMOX s47 sa36 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.08
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re7 147
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

uniprot P26016 47
type: UnificationXref
id: P26016
db: uniprot

myoglianin s84 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

DISSOCIATION_LEFT__phosphoSMOX_LACK-RIGHT__SMOX-_LACK-_re25
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 199
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 200
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 198
left: phosphoSMOX LACK
interaction type: DISSOCIATION
right: SMOX
right: LACK

SMOX s90 sa64 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 2.0

SARA s64 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s41 sa24 rs2
feature: SMOX s41 sa24 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

WIT/myoglianin phosphoBABO SARA/ phosphoSMOX
type: Complex
component stoichiometry: SMOX s67 sa43 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 45STOICHIOMETRY ID COMPLEX
component stoichiometry: SARA s64 sa42 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 30STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 20STOICHIOMETRY ID COMPLEX
component: SMOX
component: SARA
component: BABO
component: myoglianin
component: WIT
feature: COMPLEX BINDING FEATURE s71 csa9 136
feature: COMPLEX BINDING FEATURE s71 csa9 130
feature: COMPLEX BINDING FEATURE s71 csa9 128
feature: COMPLEX BINDING FEATURE s71 csa9 134
feature: COMPLEX BINDING FEATURE s71 csa9 132
cellular location: early endosome

SMOX s92 sa60 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.08
comment: MODIFICATION_RESIDUE_NAME=

PANTHER Pathway P06215 1
type: UnificationXref
id: P06215
db: PANTHER Pathway

PARTICIPANT STOICHIOMETRY re2 170
type: Stoichiometry
physical entity: WIT/myoglianin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 171
type: Stoichiometry
physical entity: WIT/myoglianin BABO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 146
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 1.0

myoglianin
type: Protein
entity reference: myoglianin

SMOX
type: Protein
entity reference: SMOX
feature: COMPLEX PARTICIPANT BINDING FEATURE s101 sa73 79
feature: SMOX s101 sa73 rs1
feature: SMOX s101 sa73 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re2 169
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

SARA
type: Protein
entity reference: SARA
feature: COMPLEX PARTICIPANT BINDING FEATURE s56 sa30 87
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

LACK s100 sa72 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Furin-like protease 1, isoforms 1/1-X/2
type: ProteinReference
xref: uniprot P26016 47
xref: PTHR42884:SF3
organism: Drosophila melanogaster

WIT
type: Protein
entity reference: WIT

myoglianin s27 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

myoglianin s30 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

MED
type: Protein
entity reference: MED
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

WIT
type: Protein
entity reference: WIT

STATE_TRANSITION_LEFT__SMOX-RIGHT__SMOX-_re16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 168
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 167
left: SMOX
interaction type: STATE_TRANSITION
right: SMOX

LACK
type: Protein
entity reference: LACK
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SMOX s92 sa60 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

WIT
type: Protein
entity reference: WIT

STATE_TRANSITION_LEFT__SMOX-RIGHT__sa76_degraded-_re26
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 197
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 196
left: SMOX
interaction type: STATE_TRANSITION
right: sa76_degraded

BABO
type: Protein
entity reference: BABO
feature: BABO s35 sa21 rs1

phosphoSMOX/ MED
type: Complex
component stoichiometry: MED s85 sa57 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 32STOICHIOMETRY ID COMPLEX
component: MED
component: myoglianin
feature: COMPLEX BINDING FEATURE s82 csa11 112
feature: COMPLEX BINDING FEATURE s82 csa11 114
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re16 168
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY re16 167
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

MED
type: ProteinReference
xref: P06311
standard name: medea
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=MYO_signaling_pathway.PROTEIN.GENERIC.MED
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein mothers against dpp
member entity reference: Mothers against decapentaplegic homolog

WIT s49 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

WIT s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: WIT
stoichiometric coefficient: 2.0

BABO s51 sa37 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

SMOX s47 sa36 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

HOMODIMER ID 43STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PTHR46319:SF3
type: RelationshipXref
id: PTHR46319:SF3
db: PANTHER Family
relationship type: By Homology

HOMODIMER ID 31STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

HOMODIMER ID 28STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

WIT/myoglianin phosphoBABO
type: Complex
component stoichiometry: HOMODIMER ID 31STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 21STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 46STOICHIOMETRY ID COMPLEX
component: WIT
component: myoglianin
component: BABO
feature: COMPLEX BINDING FEATURE s19 csa3 104
feature: COMPLEX BINDING FEATURE s19 csa3 102
feature: COMPLEX BINDING FEATURE s19 csa3 100
cellular location: cytosol

WIT
type: Protein
entity reference: WIT

myoglianin s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: myoglianin
stoichiometric coefficient: 2.0

GO GO:0005634 4
type: UnificationXref
id: GO:0005634
db: GO

GO GO:0005794 2
type: UnificationXref
id: GO:0005794
db: GO

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s92 sa60 rs2
feature: SMOX s92 sa60 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__BABO-RIGHT__BABO-_re9
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 143
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 142
left: BABO
interaction type: TRANSPORT
right: BABO

STATE_TRANSITION
type: InteractionVocabulary

MYO_signaling_pathway
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__myoglianin-_WIT-RIGHT__WIT_myoglianin-_re1
pathway component: TRANSPORT_LEFT__MED-RIGHT__MED-_re20
pathway component: TRANSPORT_LEFT__SMOX-RIGHT__SMOX-_re22
pathway component: HETERODIMER_ASSOCIATION_LEFT__WIT_myoglianin_phosphoBABO-_SARA_SMOX-RIGHT__WIT_myoglianin_phosphoBABO_SARA_SMOX-_re12
pathway component: HETERODIMER_ASSOCIATION_LEFT__BABO-_WIT_myoglianin-RIGHT__WIT_myoglianin_BABO-_re2
pathway component: STATE_TRANSITION_LEFT__WIT_myoglianin_BABO-_ATP-RIGHT__ADP-_WIT_myoglianin_phosphoBABO-_re3
pathway component: TRANSPORT_LEFT__BABO-RIGHT__BABO-_re9
pathway component: TRANSPORT_LEFT__SMOX-RIGHT__SMOX-_re23
pathway component: TRANSPORT_LEFT__phosphoSMOX__MED-RIGHT__phosphoSMOX__MED-_re21
pathway component: STATE_TRANSITION_LEFT__SMOX-_MED-RIGHT__SMOX-_phosphoSMOX__MED-_re17
pathway component: DISSOCIATION_LEFT__phosphoSMOX_LACK-RIGHT__SMOX-_LACK-_re25
pathway component: STATE_TRANSITION_LEFT__SMOX-RIGHT__sa76_degraded-_re26
pathway component: STATE_TRANSITION_LEFT__BABO-RIGHT__BABO-_re8
pathway component: HETERODIMER_ASSOCIATION_LEFT__SMOX-_LACK-RIGHT__phosphoSMOX_LACK-_re27
pathway component: HETERODIMER_ASSOCIATION_LEFT__SARA-_SMOX-RIGHT__SARA_SMOX-_re11
pathway component: STATE_TRANSITION_LEFT__WIT-RIGHT__WIT-_re7
pathway component: TRANSPORT_LEFT__WIT-RIGHT__WIT-_re10
pathway component: STATE_TRANSITION_LEFT__SMOX-RIGHT__SMOX-_re16
pathway component: DISSOCIATION_LEFT__phosphoSMOX__MED-RIGHT__MED-_SMOX-_re19
pathway component: DISSOCIATION_LEFT__WIT_myoglianin_phosphoBABO_SARA__phosphoSMOX-RIGHT__SMOX-_SMOX-_WIT_myoglianin_phosphoBABO-_re15
pathway component: DISSOCIATION_LEFT__proMyoglianin-RIGHT__myoglianin-_?-_re6
pathway component: TRANSPORT_LEFT__WIT_myoglianin_phosphoBABO_SARA_SMOX-RIGHT__WIT_myoglianin_phosphoBABO_SARA_SMOX-_re13
pathway component: TRUNCATION_LEFT__myoglianin_full_length-RIGHT__myoglianin-_?-_re4
pathway component: STATE_TRANSITION_LEFT__WIT_myoglianin_phosphoBABO_SARA_SMOX-_ATP-RIGHT__WIT_myoglianin_phosphoBABO_SARA__phosphoSMOX-_ADP-_re14
pathway component: TRANSPORT_LEFT__proMyoglianin-RIGHT__proMyoglianin-_re5
pathway component: STATE_TRANSITION_LEFT__phosphoSMOX_LACK-RIGHT__phosphoSMOX_LACK-_re24
xref: PANTHER Pathway P06215 1
comment: MODEL_NOTES=

Zinc finger FYVE domain-containing protein
type: ProteinReference
evidence: Evidence 55
xref: PTHR46319:SF3
xref: uniprot Q7K9H6 54
organism: Drosophila melanogaster

TRANSPORT
type: InteractionVocabulary

TRUNCATION
type: InteractionVocabulary

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__phosphoSMOX__MED-RIGHT__MED-_SMOX-_re19
controller: PPM1A

BABO s51 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

E3 ubiquitin-protein ligase Smurf1
type: ProteinReference
evidence: Evidence 49
xref: PTHR11254:SF395
xref: uniprot Q9V853 48
organism: Drosophila melanogaster

SMOX s41 sa24 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.08
comment: MODIFICATION_RESIDUE_NAME=

BABO
type: Protein
entity reference: BABO
feature: BABO s14 sa8 rs1

By Homology
type: RelationshipTypeVocabulary

phosphoSMOX LACK
type: Complex
component stoichiometry: SMOX s101 sa73 STOICHIOMETRY ID COMPLEX
component stoichiometry: LACK s100 sa72 STOICHIOMETRY ID COMPLEX
component: LACK
component: SMOX
feature: COMPLEX BINDING FEATURE s99 csa14 78
feature: COMPLEX BINDING FEATURE s99 csa14 76
cellular location: cytosol

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 3

uniprot Q9V4F4 7
type: UnificationXref
id: Q9V4F4
db: uniprot

SMOX s79 sa54 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 3.0

SARA s39 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

myoglianin
type: ProteinReference
xref: P06312
comment: ENTITY_REFERENCE_ID_DESC=MYO_signaling_pathway.PROTEIN.TRUNCATED.myoglianin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=
member entity reference: LD29161p

uniprot O96660 50
type: UnificationXref
id: O96660
db: uniprot

BABO s45 sa48 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

SMOX s41 sa24 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

BABO
type: Protein
entity reference: BABO
feature: BABO s58 sa29 rs1

HOMODIMER ID 46STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

SMOX s67 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

Target genes
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

WIT/myoglianin phosphoBABO
type: Complex
component stoichiometry: HOMODIMER ID 27STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 42STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 17STOICHIOMETRY ID COMPLEX
component: BABO
component: myoglianin
component: WIT
feature: COMPLEX BINDING FEATURE s72 csa10 106
feature: COMPLEX BINDING FEATURE s72 csa10 108
feature: COMPLEX BINDING FEATURE s72 csa10 110
cellular location: early endosome

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

myoglianin full length
type: Protein
entity reference: myoglianin full length

Alphabet, isoform E
type: ProteinReference
evidence: Evidence 35
xref: PTHR47992:SF25
xref: uniprot Q961C5 33
organism: Drosophila melanogaster