uniprot Q6P621 25
type: UnificationXref
id: Q6P621
db: uniprot

ncbitaxon 1111708 69
type: UnificationXref
id: 1111708
db: ncbitaxon

GDP-mannose 4,6 dehydratase 2
type: ProteinReference
xref: PTHR43715:SF1
xref: uniprot O45583 10
organism: Caenorhabditis elegans

ncbitaxon 6239 11
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot A0A1D5QBK6 90
type: UnificationXref
id: A0A1D5QBK6
db: uniprot

PTHR10309:SF0
type: RelationshipXref
id: PTHR10309:SF0
db: PANTHER Family
relationship type: By Homology

KNOWN_TRANSITION_OMITTED_LEFT__GDP_alphaL_Fucose-RIGHT__Glycoprotein-_r58
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 129
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 128
left: GDP alphaL-Fucose
interaction type: KNOWN_TRANSITION_OMITTED
right: Glycoprotein

GDP-mannose 4,6-dehydratase (Fragment)
type: ProteinReference
xref: uniprot Q6P621 25
xref: PTHR43715:SF1
organism: Xenopus tropicalis

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 49

uniprot Q8ZSW5 78
type: UnificationXref
id: Q8ZSW5
db: uniprot

uniprot P0AC88 15
type: UnificationXref
id: P0AC88
db: uniprot

uniprot Q9FZH5 47
type: UnificationXref
id: Q9FZH5
db: uniprot

Mannose 1-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot D4A746 58
type: UnificationXref
id: D4A746
db: uniprot

ncbitaxon 178306 79
type: UnificationXref
id: 178306
db: ncbitaxon

uniprot Q5RK25 101
type: UnificationXref
id: Q5RK25
db: uniprot

uniprot E2R1D1 59
type: UnificationXref
id: E2R1D1
db: uniprot

PTHR22572:SF15
type: RelationshipXref
id: PTHR22572:SF15
db: PANTHER Family
relationship type: By Homology

uniprot F7F3V5 62
type: UnificationXref
id: F7F3V5
db: uniprot

GDP-mannose 4,6 dehydratase 2
type: ProteinReference
xref: uniprot P93031 17
xref: PTHR43715:SF1
organism: Arabidopsis thaliana

eco ECO:0000304 19
type: UnificationXref
id: ECO:0000304
db: eco

Mannose 1-P guanylyl transferase
type: Protein
entity reference: Mannose 1-P guanylyl transferase
comment: SPECIES_TYPE=PROTEIN

uniprot Q9HFU4 48
type: UnificationXref
id: Q9HFU4
db: uniprot

uniprot Q5XIC1 73
type: UnificationXref
id: Q5XIC1
db: uniprot

PTHR10309:SF9
type: RelationshipXref
id: PTHR10309:SF9
db: PANTHER Family
relationship type: By Homology

Mannose-1-phosphate guanyltransferase
type: ProteinReference
xref: PTHR22572:SF147
xref: uniprot Q8ZSW5 78
organism: Pyrobaculum aerophilum

uniprot Q4Q1M7 100
type: UnificationXref
id: Q4Q1M7
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 31

Phosphomannomutase
type: ProteinReference
xref: PTHR10466:SF1
xref: uniprot Q5RK25 101
organism: Rattus norvegicus

uniprot Q3MHS7 21
type: UnificationXref
id: Q3MHS7
db: uniprot

GDP-mannose pyrophosphorylase B
type: ProteinReference
xref: uniprot A0A2I3RJT5 53
xref: PTHR22572:SF15
organism: Pan troglodytes

uniprot Q9C9P3 82
type: UnificationXref
id: Q9C9P3
db: uniprot

PARTICIPANT STOICHIOMETRY r41 118
type: Stoichiometry
physical entity: Mannose 6-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r41 119
type: Stoichiometry
physical entity: Mannose 1-phosphate
stoichiometric coefficient: 1.0

uniprot P34949 41
type: UnificationXref
id: P34949
db: uniprot

GDP-mannose 4,6-dehydratase
type: ProteinReference
xref: uniprot Q89J19 27
xref: PTHR43715:SF1
organism: Bradyrhizobium diazoefficiens

GDP-mannose 4,6-dehydratase
type: ProteinReference
xref: uniprot K7CP74 8
xref: PTHR43715:SF1
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Fructose_6_phosphate-RIGHT__Mannose_6_phosphate-_r56
controller: Mannose 6-P isomerase

Phosphomannomutase
type: ProteinReference
xref: PTHR10466:SF2
xref: uniprot B5DF46 91
organism: Rattus norvegicus

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 37

P03015
type: UnificationXref
id: P03015
db: PANTHER Pathway Component

Phosphomannomutase
type: ProteinReference
xref: PTHR10466:SF1
xref: uniprot Q0VC17 98
organism: Bos taurus

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 69

P03017
type: UnificationXref
id: P03017
db: PANTHER Pathway Component

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 104

ncbitaxon 13616 3
type: UnificationXref
id: 13616
db: ncbitaxon

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 4

Mannose-6-phosphate isomerase 2
type: ProteinReference
xref: PTHR10309:SF0
xref: uniprot Q9FZH5 47
organism: Arabidopsis thaliana

By Homology
type: RelationshipTypeVocabulary

Phosphomannomutase
type: ProteinReference
xref: PTHR10466:SF0
xref: uniprot Q4Q1M7 100
organism: Leishmania major

Mannose 6-P isomerase
type: Protein
entity reference: Mannose 6-P isomerase
comment: SPECIES_TYPE=PROTEIN

Mannose-1-phosphate guanyltransferase
type: ProteinReference
xref: uniprot P74589 70
xref: PTHR22572:SF150
organism: Synechocystis

ncbitaxon 39947 46
type: UnificationXref
id: 39947
db: ncbitaxon

ncbitaxon 100226 84
type: UnificationXref
id: 100226
db: ncbitaxon

PTHR43715:SF1
type: RelationshipXref
id: PTHR43715:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q4Q5C3 43
type: UnificationXref
id: Q4Q5C3
db: uniprot

GDP-Mannose 4,6-dehydratase
type: ProteinReference
xref: P03015
comment: ENTITY_REFERENCE_ID_DESC=Mannose metabolism.PROTEIN.GENERIC.GDP-Mannose_br_4,6-dehydratase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: GDP-Mannose 4,6-dehydratase Synonym: Synonym not specified Accession: P03015
member entity reference: GDP-mannose 4,6 dehydratase
member entity reference: GDP-mannose 4,6-dehydratase
member entity reference: GDP-mannose 4, 6-dehydratase
member entity reference: GDP-mannose 4,6 dehydratase 2
member entity reference: GDP-mannose 4,6-dehydratase (Fragment)
member entity reference: GDP-mannose 4,6 dehydratase 1

PARTICIPANT STOICHIOMETRY r57 131
type: Stoichiometry
physical entity: GDP alphaL-Fucose
stoichiometric coefficient: 1.0

GDP-mannose pyrophosphorylase A
type: ProteinReference
xref: PTHR22572:SF104
xref: uniprot A0A2I3RCI1 52
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r57 130
type: Stoichiometry
physical entity: GDP-4-dehydro 6-deoxy-D-mannose
stoichiometric coefficient: 1.0

Mannose 6-P isomerase
type: ProteinReference
xref: P03017
comment: ENTITY_REFERENCE_ID_DESC=Mannose metabolism.PROTEIN.GENERIC.Mannose 6-P_br_isomerase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Mannose 6-P isomerase Synonym: Phosphomannose isomerase Accession: P03017
member entity reference: Mannose-6-phosphate isomerase 2
member entity reference: Mannose-6-phosphate isomerase
member entity reference: Uncharacterized protein
member entity reference: Mannose-6-phosphate isomerase 1

GDP-4-dehydro 6-deoxy-D-mannose
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P74589 70
type: UnificationXref
id: P74589
db: uniprot

Mannose 1-P guanylyl transferase
type: ProteinReference
xref: P03018
comment: ENTITY_REFERENCE_ID_DESC=Mannose metabolism.PROTEIN.GENERIC.Mannose 1-P_br_guanylyl transferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Mannose 1-P guanylyl transferase Synonym: GDP-mannose pyrophosphorylase Accession: P03018
member entity reference: Mannose-1-phosphate guanyltransferase alpha
member entity reference: Putative mannose-1-phosphate guanyltransferase
member entity reference: Mannose-1-phosphate guanyltransferase beta
member entity reference: Uncharacterized protein
member entity reference: GDP-mannose pyrophosphorylase B
member entity reference: Probable mannose-1-phosphate guanylyltransferase 2
member entity reference: Mannose-1-phosphate guanyltransferase
member entity reference: Mannose-1-phosphate guanyltransferase, putative
member entity reference: Protein CBG12186
member entity reference: GDP-mannose pyrophosphorylase A
member entity reference: ADP-glucose pyrophosphorylase family protein
member entity reference: UTP--glucose-1-phosphate uridylyltransferase
member entity reference: Probable mannose-1-phosphate guanylyltransferase 3
member entity reference: Mannose-1-phosphate guanylyltransferase 1

uniprot P31353 97
type: UnificationXref
id: P31353
db: uniprot

uniprot A8XF15 56
type: UnificationXref
id: A8XF15
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 3

PARTICIPANT STOICHIOMETRY r56 133
type: Stoichiometry
physical entity: Mannose 6-phosphate
stoichiometric coefficient: 1.0

ncbitaxon 224911 28
type: UnificationXref
id: 224911
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r56 132
type: Stoichiometry
physical entity: Fructose 6-phosphate
stoichiometric coefficient: 1.0

Mannose-1-phosphate guanyltransferase, putative
type: ProteinReference
xref: uniprot Q9RWF8 87
xref: PTHR43584:SF3
organism: Deinococcus radiodurans

ncbitaxon 559292 37
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot O60547 13
type: UnificationXref
id: O60547
db: uniprot

ncbitaxon 10116 22
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot Q0VC17 98
type: UnificationXref
id: Q0VC17
db: uniprot

GDP-Mannose 4,6-dehydratase
type: Protein
entity reference: GDP-Mannose 4,6-dehydratase
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r40 123
type: Stoichiometry
physical entity: Pyruvate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r44 113
type: Stoichiometry
physical entity: Mannose 1-phosphate
stoichiometric coefficient: 1.0

Mannose-6-phosphate isomerase
type: ProteinReference
xref: uniprot Q9HFU4 48
xref: PTHR10309:SF0
organism: Cryptococcus neoformans

PARTICIPANT STOICHIOMETRY r40 122
type: Stoichiometry
physical entity: Glyceraldehyde 3-P
stoichiometric coefficient: 1.0

Ashbya gossypii
type: BioSource
xref: ncbitaxon 284811 75

uniprot A5A6K3 32
type: UnificationXref
id: A5A6K3
db: uniprot

PARTICIPANT STOICHIOMETRY r44 114
type: Stoichiometry
physical entity: GDP D-Mannose
stoichiometric coefficient: 1.0

uniprot A0A3Q1LUF4 54
type: UnificationXref
id: A0A3Q1LUF4
db: uniprot

STATE_TRANSITION_LEFT__Glucose-RIGHT__Glucose_6_phosphate-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 110
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 109
left: Glucose
interaction type: STATE_TRANSITION
right: Glucose 6-phosphate

Glycoprotein
type: Protein
comment: SPECIES_TYPE=PROTEIN

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 9

STATE_TRANSITION_LEFT__Mannose_1_phosphate-RIGHT__GDP_D_Mannose-_r44
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 113
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 114
left: Mannose 1-phosphate
interaction type: STATE_TRANSITION
right: GDP D-Mannose

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 26

uniprot F4IFA4 61
type: UnificationXref
id: F4IFA4
db: uniprot

ncbitaxon 224324 66
type: UnificationXref
id: 224324
db: ncbitaxon

GDP-mannose 4,6 dehydratase
type: ProteinReference
xref: uniprot Q8K0C9 30
xref: PTHR43715:SF1
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR22572:SF15
xref: uniprot F7GRF0 63
organism: Macaca mulatta

uniprot A0A2I3RJT5 53
type: UnificationXref
id: A0A2I3RJT5
db: uniprot

uniprot Q8K0C9 30
type: UnificationXref
id: Q8K0C9
db: uniprot

KNOWN_TRANSITION_OMITTED_LEFT__GDP_4_dehydro_6_deoxy_D_mannose-RIGHT__GDP_alphaL_Fucose-_r57
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 130
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 131
left: GDP-4-dehydro 6-deoxy-D-mannose
interaction type: KNOWN_TRANSITION_OMITTED
right: GDP alphaL-Fucose

P03021
type: UnificationXref
id: P03021
db: PANTHER Pathway Component

ncbitaxon 8364 26
type: UnificationXref
id: 8364
db: ncbitaxon

P-Mannose mutase
type: Protein
entity reference: P-Mannose mutase
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT___Alginate_n-_GDP_D_Mannose-RIGHT__GDP-__Alginate_n_PLUS_1-_r61
controller: Alginate synthase

P03018
type: UnificationXref
id: P03018
db: PANTHER Pathway Component

P03019
type: UnificationXref
id: P03019
db: PANTHER Pathway Component

P-Mannose mutase
type: ProteinReference
xref: P03019
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Mannose metabolism.PROTEIN.GENERIC.P-Mannose_br_mutase
comment: ENTITY_REFERENCE_NOTES= Long Name: P-Mannose mutase Synonym: D-mannose 1,6-phosphomutase,Phosphomannose mutase Accession: P03019
member entity reference: Phosphomannomutase 1
member entity reference: Phosphomannomutase
member entity reference: Probable phosphomannomutase
member entity reference: Phosphomannomutase 2

Phosphomannomutase
type: ProteinReference
xref: uniprot E2R832 92
xref: PTHR10466:SF2
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: uniprot O16315 33
organism: Caenorhabditis elegans

uniprot O16315 33
type: UnificationXref
id: O16315
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F3V5 62
xref: PTHR22572:SF104
organism: Monodelphis domestica

uniprot Q3SZJ9 99
type: UnificationXref
id: Q3SZJ9
db: uniprot

UDP-N-acetyl-D-glucosamine 6-dehydrogenase
type: ProteinReference
xref: uniprot G3XD94 106
organism: Pseudomonas aeruginosa

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 88

GDP-mannose pyrophosphorylase A
type: ProteinReference
xref: uniprot E2R1D1 59
xref: PTHR22572:SF104
organism: Canis lupus familiaris

uniprot Q18801 20
type: UnificationXref
id: Q18801
db: uniprot

Alginate synthase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 14

uniprot Q9VTZ6 103
type: UnificationXref
id: Q9VTZ6
db: uniprot

PTHR43750:SF1
type: RelationshipXref
id: PTHR43750:SF1
db: PANTHER Family
relationship type: By Homology

ncbitaxon 227321 35
type: UnificationXref
id: 227321
db: ncbitaxon

Mannose 6-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9544 7
type: UnificationXref
id: 9544
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r5 109
type: Stoichiometry
physical entity: Glucose
stoichiometric coefficient: 1.0

Phosphomannomutase 2
type: ProteinReference
xref: uniprot Q3SZJ9 99
xref: PTHR10466:SF2
organism: Bos taurus

eco ECO:0000303 42
type: UnificationXref
id: ECO:0000303
db: eco

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 18

ncbitaxon 214684 49
type: UnificationXref
id: 214684
db: ncbitaxon

PTHR43584:SF3
type: RelationshipXref
id: PTHR43584:SF3
db: PANTHER Family
relationship type: By Homology

Fructose 6-phosphate
type: SmallMolecule
cellular location: Glycolysis c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

GDP-mannose 4,6 dehydratase
type: ProteinReference
xref: PTHR43715:SF1
xref: uniprot F7GZ39 6
organism: Macaca mulatta

GDP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 6238 57
type: UnificationXref
id: 6238
db: ncbitaxon

Phosphomannomutase 2
type: ProteinReference
xref: uniprot Q9Z2M7 105
xref: PTHR10466:SF2
organism: Mus musculus

Dihydroxyacetone 3-P
type: SmallMolecule
cellular location: Glycolysis c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P74285 68
type: UnificationXref
id: P74285
db: uniprot

uniprot Q89TZ1 29
type: UnificationXref
id: Q89TZ1
db: uniprot

ncbitaxon 9598 9
type: UnificationXref
id: 9598
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r5 110
type: Stoichiometry
physical entity: Glucose 6-phosphate
stoichiometric coefficient: 1.0

uniprot H2QLS6 93
type: UnificationXref
id: H2QLS6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GDP_D_Mannose-RIGHT__GDP_4_dehydro_6_deoxy_D_mannose-_r55
controller: GDP-Mannose 4,6-dehydratase

Probable mannose-1-phosphate guanylyltransferase 2
type: ProteinReference
xref: PTHR22572:SF15
xref: uniprot Q9M2S0 85
organism: Arabidopsis thaliana

KNOWN_TRANSITION_OMITTED_LEFT__Glyceraldehyde_3_P-RIGHT__Pyruvate-_r40
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 122
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 123
left: Glyceraldehyde 3-P
interaction type: KNOWN_TRANSITION_OMITTED
right: Pyruvate

Mannose metabolism
type: Pathway
pathway component: STATE_TRANSITION_LEFT___Alginate_n-_GDP_D_Mannose-RIGHT__GDP-__Alginate_n_PLUS_1-_r61
pathway component: TRUNCATION_LEFT__Fructose_1,6_phosphate-RIGHT__Dihydroxyacetone_3_P-_Glyceraldehyde_3_P-_r39
pathway component: STATE_TRANSITION_LEFT__GDP_D_Mannose-RIGHT__GDP_4_dehydro_6_deoxy_D_mannose-_r55
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__GDP_4_dehydro_6_deoxy_D_mannose-RIGHT__GDP_alphaL_Fucose-_r57
pathway component: STATE_TRANSITION_LEFT__Glucose-RIGHT__Glucose_6_phosphate-_r5
pathway component: STATE_TRANSITION_LEFT__Fructose_6_phosphate-RIGHT__Fructose_1,6_phosphate-_r38
pathway component: STATE_TRANSITION_LEFT__Mannose_1_phosphate-RIGHT__GDP_D_Mannose-_r44
pathway component: STATE_TRANSITION_LEFT__Mannose_6_phosphate-RIGHT__Mannose_1_phosphate-_r41
pathway component: STATE_TRANSITION_LEFT__Glucose_6_phosphate-RIGHT__Fructose_6_phosphate-_r6
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__Glyceraldehyde_3_P-RIGHT__Pyruvate-_r40
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__GDP_alphaL_Fucose-RIGHT__Glycoprotein-_r58
pathway component: STATE_TRANSITION_LEFT__Fructose_6_phosphate-RIGHT__Mannose_6_phosphate-_r56
xref: PANTHER Pathway P02752 1
comment: MODEL_NOTES= The degradation of many polysaccharides and glycoproteins yields mannose, which is phosphorylated by hexokinase to generate mannose-6-phosphate. Mannose-6-phosphate is converted to fructose-6-phosphate, and then enters the glycolytic pathway or is converted to glucose-6-phosphate by the gluconeogenic pathway. free text=Biochemiscal Pathways - An Atlas of Biochemistry and Molecular Biology Edited by Gerhard Michal free text=Biochemistry by Voet and Voet free text=Color Atlas of Biochemistry by Jan Koolman and Klaus-Heinrich Rohm

ncbitaxon 3702 18
type: UnificationXref
id: 3702
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r6 135
type: Stoichiometry
physical entity: Fructose 6-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r38 120
type: Stoichiometry
physical entity: Fructose 6-phosphate
stoichiometric coefficient: 1.0

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 16

PARTICIPANT STOICHIOMETRY r6 134
type: Stoichiometry
physical entity: Glucose 6-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r38 121
type: Stoichiometry
physical entity: Fructose 1,6-phosphate
stoichiometric coefficient: 1.0

Mannose-1-phosphate guanyltransferase beta
type: ProteinReference
xref: uniprot Q9Y5P6 89
xref: PTHR22572:SF15
organism: Homo sapiens

uniprot P34948 39
type: UnificationXref
id: P34948
db: uniprot

TRUNCATION
type: RelationshipTypeVocabulary

GDP-mannose 6-dehydrogenase
type: ProteinReference
xref: PTHR43750:SF1
xref: uniprot P11759 107
organism: Pseudomonas aeruginosa

uniprot O35621 96
type: UnificationXref
id: O35621
db: uniprot

uniprot F6Z8R0 2
type: UnificationXref
id: F6Z8R0
db: uniprot

uniprot F7GZ39 6
type: UnificationXref
id: F7GZ39
db: uniprot

GDP-mannose 4,6-dehydratase
type: ProteinReference
xref: PTHR43715:SF1
xref: uniprot Q51366 23
organism: Pseudomonas aeruginosa

GDP-mannose 4,6 dehydratase
type: ProteinReference
xref: uniprot O60547 13
xref: PTHR43715:SF1
organism: Homo sapiens

Phosphomannomutase 1
type: ProteinReference
xref: PTHR10466:SF1
xref: uniprot Q92871 102
organism: Homo sapiens

uniprot A0A1D5QED6 51
type: UnificationXref
id: A0A1D5QED6
db: uniprot

eco ECO:0000501 12
type: UnificationXref
id: ECO:0000501
db: eco

TRUNCATION_LEFT__Fructose_1,6_phosphate-RIGHT__Dihydroxyacetone_3_P-_Glyceraldehyde_3_P-_r39
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 115
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 117
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 116
left: Fructose 1,6-phosphate
interaction type: TRUNCATION
right: Glyceraldehyde 3-P
right: Dihydroxyacetone 3-P

ncbitaxon 208964 24
type: UnificationXref
id: 208964
db: ncbitaxon

uniprot Q9RJK6 108
type: UnificationXref
id: Q9RJK6
db: uniprot

Protein CBG12186
type: ProteinReference
xref: uniprot A8XF15 56
xref: PTHR22572:SF104
organism: Caenorhabditis briggsae

uniprot Q9KZP4 83
type: UnificationXref
id: Q9KZP4
db: uniprot

Mannose-6-phosphate isomerase
type: ProteinReference
xref: uniprot Q4Q5C3 43
xref: PTHR10309:SF0
organism: Leishmania major

Mannose-1-phosphate guanyltransferase
type: ProteinReference
xref: PTHR22572:SF15
xref: uniprot P41940 67
organism: Saccharomyces cerevisiae

Phosphomannomutase
type: ProteinReference
xref: PTHR10466:SF0
xref: uniprot P31353 97
organism: Candida albicans

Mannose-6-phosphate isomerase
type: ProteinReference
xref: uniprot A5A6K3 32
xref: PTHR10309:SF0
organism: Pan troglodytes

Pyruvate
type: SmallMolecule
cellular location: Glycolysis c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PANTHER Pathway P02752 1
type: UnificationXref
id: P02752
db: PANTHER Pathway

PTHR22572:SF150
type: RelationshipXref
id: PTHR22572:SF150
db: PANTHER Family
relationship type: By Homology

eco ECO:0000250 4
type: UnificationXref
id: ECO:0000250
db: eco

Phosphomannomutase
type: ProteinReference
xref: uniprot K7CN12 94
xref: PTHR10466:SF2
organism: Pan troglodytes

Phosphomannomutase
type: ProteinReference
xref: uniprot A0A1D5QBK6 90
xref: PTHR10466:SF2
organism: Macaca mulatta

GDP-mannose 4,6-dehydratase
type: ProteinReference
xref: uniprot P0AC88 15
xref: PTHR43715:SF1
organism: Escherichia coli

uniprot Q922H4 80
type: UnificationXref
id: Q922H4
db: uniprot

GDP Mannose 6-dehydrogenase
type: ProteinReference
xref: P03021
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Mannose metabolism.PROTEIN.GENERIC.GDP Mannose_br_6-dehydrogenase
comment: ENTITY_REFERENCE_NOTES= Long Name: GDP Mannose 6-dehydrogenase Synonym: Synonym not specified Accession: P03021
member entity reference: UDP-glucose/GDP-mannose family dehydrogenase (Putative secreted protein)
member entity reference: UDP-N-acetyl-D-glucosamine 6-dehydrogenase
member entity reference: GDP-mannose 6-dehydrogenase

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LUF4 54
xref: PTHR22572:SF104
organism: Bos taurus

Bos taurus
type: BioSource
xref: ncbitaxon 9913 55

uniprot Q51366 23
type: UnificationXref
id: Q51366
db: uniprot

CATALYSIS
type: Catalysis
controller: GDP Mannose 6-dehydrogenase

ncbitaxon 243230 88
type: UnificationXref
id: 243230
db: ncbitaxon

uniprot F7GRF0 63
type: UnificationXref
id: F7GRF0
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 7

IDA
type: EvidenceCodeVocabulary

uniprot Q9FTR6 45
type: UnificationXref
id: Q9FTR6
db: uniprot

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 12

Mannose-1-phosphate guanyltransferase
type: ProteinReference
xref: uniprot O66933 65
xref: PTHR22572:SF150
organism: Aquifex aeolicus

NAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000303 42

Glycolysis c3
type: CellularLocationVocabulary
comment: Glycolysis

GDP alphaL-Fucose
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 19

STATE_TRANSITION_LEFT__Glucose_6_phosphate-RIGHT__Fructose_6_phosphate-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 135
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 134
left: Glucose 6-phosphate
interaction type: STATE_TRANSITION
right: Fructose 6-phosphate

ncbitaxon 284811 75
type: UnificationXref
id: 284811
db: ncbitaxon

PTHR22572:SF137
type: RelationshipXref
id: PTHR22572:SF137
db: PANTHER Family
relationship type: By Homology

PTHR10466:SF2
type: RelationshipXref
id: PTHR10466:SF2
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r39 117
type: Stoichiometry
physical entity: Glyceraldehyde 3-P
stoichiometric coefficient: 1.0

PTHR10466:SF1
type: RelationshipXref
id: PTHR10466:SF1
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r39 116
type: Stoichiometry
physical entity: Dihydroxyacetone 3-P
stoichiometric coefficient: 1.0

PTHR10466:SF0
type: RelationshipXref
id: PTHR10466:SF0
db: PANTHER Family
relationship type: By Homology

uniprot Q9N4V3 86
type: UnificationXref
id: Q9N4V3
db: uniprot

uniprot Q8H1Q7 77
type: UnificationXref
id: Q8H1Q7
db: uniprot

Mannose-1-phosphate guanyltransferase alpha
type: ProteinReference
xref: PTHR22572:SF104
xref: uniprot Q5XIC1 73
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r39 115
type: Stoichiometry
physical entity: Fructose 1,6-phosphate
stoichiometric coefficient: 1.0

uniprot G3XD94 106
type: UnificationXref
id: G3XD94
db: uniprot

ncbitaxon 5664 44
type: UnificationXref
id: 5664
db: ncbitaxon

uniprot Q4QBG5 72
type: UnificationXref
id: Q4QBG5
db: uniprot

Glyceraldehyde 3-P
type: SmallMolecule
cellular location: Glycolysis c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot K7CP74 8
type: UnificationXref
id: K7CP74
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 22

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 66

Mannose-6-phosphate isomerase
type: ProteinReference
xref: uniprot Q9FTR6 45
xref: PTHR10309:SF0
organism: Oryza sativa

ADP-glucose pyrophosphorylase family protein
type: ProteinReference
xref: uniprot Q9C9P3 82
xref: PTHR22572:SF104
organism: Arabidopsis thaliana

ncbitaxon 9913 55
type: UnificationXref
id: 9913
db: ncbitaxon

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 60

PARTICIPANT STOICHIOMETRY r61 124
type: Stoichiometry
physical entity: (Alginate)n
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r61 125
type: Stoichiometry
physical entity: GDP D-Mannose
stoichiometric coefficient: 1.0

Fructose 1,6-phosphate
type: SmallMolecule
cellular location: Glycolysis c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Phosphomannomutase
type: ProteinReference
xref: PTHR10466:SF1
xref: uniprot H2QLS6 93
organism: Pan troglodytes

(Alginate)n+1
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r61 126
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot O15305 95
type: UnificationXref
id: O15305
db: uniprot

PARTICIPANT STOICHIOMETRY r61 127
type: Stoichiometry
physical entity: (Alginate)n+1
stoichiometric coefficient: 1.0

uniprot Q9RWF8 87
type: UnificationXref
id: Q9RWF8
db: uniprot

uniprot B5DF46 91
type: UnificationXref
id: B5DF46
db: uniprot

PTHR22572:SF147
type: RelationshipXref
id: PTHR22572:SF147
db: PANTHER Family
relationship type: By Homology

GDP-mannose 4,6-dehydratase
type: ProteinReference
xref: uniprot F6Z8R0 2
xref: PTHR43715:SF1
organism: Monodelphis domestica

PTHR22572:SF146
type: RelationshipXref
id: PTHR22572:SF146
db: PANTHER Family
relationship type: By Homology

UDP-glucose/GDP-mannose family dehydrogenase (Putative secreted protein)
type: ProteinReference
xref: PTHR43750:SF1
xref: uniprot Q9RJK6 108
organism: Streptomyces coelicolor

STATE_TRANSITION_LEFT__Fructose_6_phosphate-RIGHT__Mannose_6_phosphate-_r56
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 133
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 132
left: Fructose 6-phosphate
interaction type: STATE_TRANSITION
right: Mannose 6-phosphate

Bradyrhizobium diazoefficiens
type: BioSource
xref: ncbitaxon 224911 28

PTHR22572:SF141
type: RelationshipXref
id: PTHR22572:SF141
db: PANTHER Family
relationship type: By Homology

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 79

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Mannose_6_phosphate-RIGHT__Mannose_1_phosphate-_r41
controller: P-Mannose mutase

uniprot P29952 36
type: UnificationXref
id: P29952
db: uniprot

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

Mannose-1-phosphate guanyltransferase alpha
type: ProteinReference
xref: uniprot Q922H4 80
xref: PTHR22572:SF104
organism: Mus musculus

Mannose-6-phosphate isomerase
type: ProteinReference
xref: uniprot P29951 34
xref: PTHR10309:SF0
organism: Emericella nidulans

GDP-mannose 4,6 dehydratase 1
type: ProteinReference
xref: uniprot Q18801 20
xref: PTHR43715:SF1
organism: Caenorhabditis elegans

Mannose-6-phosphate isomerase
type: ProteinReference
xref: uniprot P29952 36
xref: PTHR10309:SF0
organism: Saccharomyces cerevisiae

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 84

uniprot O22287 64
type: UnificationXref
id: O22287
db: uniprot

uniprot P11759 107
type: UnificationXref
id: P11759
db: uniprot

uniprot Q2YDJ9 71
type: UnificationXref
id: Q2YDJ9
db: uniprot

Glucose 6-phosphate
type: SmallMolecule
cellular location: Glycolysis c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

uniprot Q9Z2M7 105
type: UnificationXref
id: Q9Z2M7
db: uniprot

PARTICIPANT STOICHIOMETRY r55 111
type: Stoichiometry
physical entity: GDP D-Mannose
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r55 112
type: Stoichiometry
physical entity: GDP-4-dehydro 6-deoxy-D-mannose
stoichiometric coefficient: 1.0

Probable mannose-1-phosphate guanylyltransferase 3
type: ProteinReference
xref: uniprot Q8H1Q7 77
xref: PTHR22572:SF141
organism: Arabidopsis thaliana

TRUNCATION
type: InteractionVocabulary

(Alginate)n
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9M2S0 85
type: UnificationXref
id: Q9M2S0
db: uniprot

Probable phosphomannomutase
type: ProteinReference
xref: PTHR10466:SF0
xref: uniprot Q9VTZ6 103
organism: Drosophila melanogaster

Glucose
type: SmallMolecule
cellular location: Glycolysis c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT___Alginate_n-_GDP_D_Mannose-RIGHT__GDP-__Alginate_n_PLUS_1-_r61
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 126
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 125
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 127
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 124
left: GDP D-Mannose
left: (Alginate)n
interaction type: STATE_TRANSITION
right: (Alginate)n+1
right: GDP

uniprot Q9M884 50
type: UnificationXref
id: Q9M884
db: uniprot

uniprot P93031 17
type: UnificationXref
id: P93031
db: uniprot

ncbitaxon 9615 60
type: UnificationXref
id: 9615
db: ncbitaxon

Candida albicans
type: BioSource
xref: ncbitaxon 237561 40

uniprot Q96IJ6 81
type: UnificationXref
id: Q96IJ6
db: uniprot

KNOWN_TRANSITION_OMITTED
type: InteractionVocabulary

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9N4V3 86
xref: PTHR22572:SF104
organism: Caenorhabditis elegans

GDP D-Mannose
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9Y5P6 89
type: UnificationXref
id: Q9Y5P6
db: uniprot

Mannose-1-phosphate guanyltransferase alpha
type: ProteinReference
xref: uniprot A0A1D5QED6 51
xref: PTHR22572:SF104
organism: Macaca mulatta

uniprot K7CN12 94
type: UnificationXref
id: K7CN12
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 44

UTP--glucose-1-phosphate uridylyltransferase
type: ProteinReference
xref: uniprot P74285 68
xref: PTHR22572:SF137
organism: Synechocystis

ncbitaxon 10090 31
type: UnificationXref
id: 10090
db: ncbitaxon

Mannose-1-phosphate guanylyltransferase 1
type: ProteinReference
xref: PTHR22572:SF15
xref: uniprot O22287 64
organism: Arabidopsis thaliana

Mannose-1-phosphate guanyltransferase beta
type: ProteinReference
xref: PTHR22572:SF15
xref: uniprot Q2YDJ9 71
organism: Bos taurus

uniprot O66933 65
type: UnificationXref
id: O66933
db: uniprot

uniprot Q752H4 74
type: UnificationXref
id: Q752H4
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 57

PARTICIPANT STOICHIOMETRY r58 129
type: Stoichiometry
physical entity: Glycoprotein
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 128
type: Stoichiometry
physical entity: GDP alphaL-Fucose
stoichiometric coefficient: 1.0

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 11

ncbitaxon 9606 14
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot Q92871 102
type: UnificationXref
id: Q92871
db: uniprot

Mannose-6-phosphate isomerase 1
type: ProteinReference
xref: PTHR10309:SF9
xref: uniprot Q9M884 50
organism: Arabidopsis thaliana

GDP Mannose 6-dehydrogenase
type: Protein
entity reference: GDP Mannose 6-dehydrogenase
comment: SPECIES_TYPE=PROTEIN

uniprot E2R832 92
type: UnificationXref
id: E2R832
db: uniprot

Glycoconjugates
type: Protein
comment: SPECIES_TYPE=PROTEIN

Mannose-1-phosphate guanyltransferase
type: ProteinReference
xref: PTHR22572:SF15
xref: uniprot Q4QBG5 72
organism: Leishmania major

ncbitaxon 237561 40
type: UnificationXref
id: 237561
db: ncbitaxon

STATE_TRANSITION_LEFT__Mannose_6_phosphate-RIGHT__Mannose_1_phosphate-_r41
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 118
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 119
left: Mannose 6-phosphate
interaction type: STATE_TRANSITION
right: Mannose 1-phosphate

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Mannose_1_phosphate-RIGHT__GDP_D_Mannose-_r44
controller: Mannose 1-P guanylyl transferase

uniprot Q89J19 27
type: UnificationXref
id: Q89J19
db: uniprot

uniprot Q8BTZ7 76
type: UnificationXref
id: Q8BTZ7
db: uniprot

GDP-mannose 4,6-dehydratase
type: ProteinReference
xref: uniprot Q89TZ1 29
xref: PTHR43715:SF1
organism: Bradyrhizobium diazoefficiens

uniprot O45583 10
type: UnificationXref
id: O45583
db: uniprot

STATE_TRANSITION_LEFT__Fructose_6_phosphate-RIGHT__Fructose_1,6_phosphate-_r38
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 121
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 120
left: Fructose 6-phosphate
interaction type: STATE_TRANSITION
right: Fructose 1,6-phosphate

Phosphomannomutase 2
type: ProteinReference
xref: PTHR10466:SF2
xref: uniprot O15305 95
organism: Homo sapiens

Putative mannose-1-phosphate guanyltransferase
type: ProteinReference
xref: PTHR22572:SF150
xref: uniprot Q9KZP4 83
organism: Streptomyces coelicolor

uniprot P29951 34
type: UnificationXref
id: P29951
db: uniprot

GDP-mannose 4, 6-dehydratase
type: ProteinReference
xref: PTHR43715:SF1
xref: uniprot Q3MHS7 21
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__GDP_D_Mannose-RIGHT__GDP_4_dehydro_6_deoxy_D_mannose-_r55
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 111
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 112
left: GDP D-Mannose
interaction type: STATE_TRANSITION
right: GDP-4-dehydro 6-deoxy-D-mannose

Phosphomannomutase 1
type: ProteinReference
xref: PTHR10466:SF1
xref: uniprot O35621 96
organism: Mus musculus

uniprot A0A2I3RCI1 52
type: UnificationXref
id: A0A2I3RCI1
db: uniprot

PTHR22572:SF104
type: RelationshipXref
id: PTHR22572:SF104
db: PANTHER Family
relationship type: By Homology

ADP-glucose pyrophosphorylase family protein
type: ProteinReference
xref: PTHR22572:SF146
xref: uniprot F4IFA4 61
organism: Arabidopsis thaliana

GDP-mannose pyrophosphorylase B
type: ProteinReference
xref: PTHR22572:SF15
xref: uniprot D4A746 58
organism: Rattus norvegicus

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 35

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 46

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 24

Mannose-1-phosphate guanyltransferase beta
type: ProteinReference
xref: PTHR22572:SF15
xref: uniprot Q8BTZ7 76
organism: Mus musculus

Mannose-1-phosphate guanyltransferase alpha
type: ProteinReference
xref: uniprot Q96IJ6 81
xref: PTHR22572:SF104
organism: Homo sapiens

uniprot P41940 67
type: UnificationXref
id: P41940
db: uniprot

ncbitaxon 7227 104
type: UnificationXref
id: 7227
db: ncbitaxon

Mannose-6-phosphate isomerase
type: ProteinReference
xref: uniprot P34949 41
xref: PTHR10309:SF0
organism: Homo sapiens

Mannose-1-phosphate guanyltransferase
type: ProteinReference
xref: uniprot Q752H4 74
xref: PTHR22572:SF15
organism: Ashbya gossypii

Mannose-6-phosphate isomerase
type: ProteinReference
xref: uniprot P34948 39
xref: PTHR10309:SF0
organism: Candida albicans

ncbitaxon 83333 16
type: UnificationXref
id: 83333
db: ncbitaxon