uniprot Q14831 361
type: UnificationXref
id: Q14831
db: uniprot

G protein subunit alpha i3
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot H2PZK9 425
organism: Pan troglodytes

uniprot Q5BJ11 486
type: UnificationXref
id: Q5BJ11
db: uniprot

Amino acid transporter
type: ProteinReference
xref: uniprot A0A1D5Q6W9 108
xref: PTHR11958:SF24
organism: Macaca mulatta

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: uniprot P07278 52
xref: PTHR11635:SF152
organism: Saccharomyces cerevisiae

By Homology
type: RelationshipTypeVocabulary

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IFL6 369
organism: Bos taurus

Metabotropic glutamate receptor 7
type: ProteinReference
xref: uniprot Q14831 361
xref: PTHR24060:SF98
organism: Homo sapiens

Metabotropic glutamate receptor 4
type: ProteinReference
xref: uniprot Q14833 362
xref: PTHR24060:SF23
organism: Homo sapiens

Mus musculus
type: BioSource
xref: ncbitaxon 10090 49

Ionotropic glutamate receptor AMPA 1
type: ProteinReference
xref: PTHR18966:SF157
xref: uniprot G0T3G6 573
organism: Bos taurus

uniprot A0A0R4ING5 519
type: UnificationXref
id: A0A0R4ING5
db: uniprot

ncbitaxon 9031 6
type: UnificationXref
id: 9031
db: ncbitaxon

cAMP
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P42261 586
type: UnificationXref
id: P42261
db: uniprot

PTHR19305:SF14
type: RelationshipXref
id: PTHR19305:SF14
db: PANTHER Family
relationship type: By Homology

PTHR10218:SF310
type: RelationshipXref
id: PTHR10218:SF310
db: PANTHER Family
relationship type: By Homology

Amino acid transporter
type: ProteinReference
xref: uniprot O77062 135
xref: PTHR11958:SF63
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r62 685
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot F7FKB2 128
type: UnificationXref
id: F7FKB2
db: uniprot

PARTICIPANT STOICHIOMETRY r62 686
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot H2RC26 274
type: UnificationXref
id: H2RC26
db: uniprot

Glutamate ionotropic receptor NMDA type subunit 2A
type: ProteinReference
evidence: Evidence 169
evidence: Evidence 168
evidence: Evidence 171
evidence: Evidence 170
xref: PTHR18966:SF407
xref: uniprot F1PXS6 180
organism: Canis lupus familiaris

uniprot H2QLA1 272
type: UnificationXref
id: H2QLA1
db: uniprot

ncbitaxon 9544 23
type: UnificationXref
id: 9544
db: ncbitaxon

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 84

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot F7F746 567
organism: Macaca mulatta

uniprot P83351 303
type: UnificationXref
id: P83351
db: uniprot

PRKAR1A isoform 12
type: ProteinReference
xref: uniprot H2R3M7 39
xref: PTHR11635:SF129
organism: Pan troglodytes

Vesicular glutamate transporter 1
type: ProteinReference
xref: PTHR11662:SF29
xref: uniprot A4FV52 162
organism: Bos taurus

uniprot P21137 67
type: UnificationXref
id: P21137
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot F7CTP1 409
organism: Macaca mulatta

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60879 291
xref: PTHR19305:SF5
organism: Mus musculus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60878 290
xref: PTHR19305:SF5
organism: Gallus gallus

uniprot Q03391 205
type: UnificationXref
id: Q03391
db: uniprot

uniprot P05132 48
type: UnificationXref
id: P05132
db: uniprot

Putative synaptobrevin homologue SNC1/2 (Eurofung)
type: ProteinReference
xref: uniprot Q5ASG1 313
organism: Emericella nidulans

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60877 289
organism: Macaca mulatta

uniprot A0A452J7P8 535
type: UnificationXref
id: A0A452J7P8
db: uniprot

ncbitaxon 10090 49
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot Q9SD96 329
type: UnificationXref
id: Q9SD96
db: uniprot

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60880 292
xref: PTHR19305:SF5
organism: Homo sapiens

uniprot X1WDQ5 518
type: UnificationXref
id: X1WDQ5
db: uniprot

uniprot Q7Q3T7 96
type: UnificationXref
id: Q7Q3T7
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q2KJD2 311
organism: Bos taurus

uniprot P36975 288
type: UnificationXref
id: P36975
db: uniprot

Glutamate receptor, ionotropic, AMPA 4a
type: ProteinReference
xref: PTHR18966:SF488
xref: uniprot F1QA08 553
organism: Danio rerio

Glutamate ionotropic receptor AMPA type subunit 4
type: ProteinReference
xref: PTHR18966:SF100
xref: uniprot A0A2I3T3T7 529
organism: Pan troglodytes

uniprot E2R2S8 383
type: UnificationXref
id: E2R2S8
db: uniprot

Glutamate receptor ionotropic, NMDA 3B
type: ProteinReference
evidence: Evidence 173
evidence: Evidence 168
xref: PTHR18966:SF364
xref: uniprot Q8VHN2 218
organism: Rattus norvegicus

uniprot P31596 137
type: UnificationXref
id: P31596
db: uniprot

uniprot P12367 56
type: UnificationXref
id: P12367
db: uniprot

uniprot H2Q9G5 428
type: UnificationXref
id: H2Q9G5
db: uniprot

Synaptobrevin-1
type: ProteinReference
xref: uniprot O02495 278
xref: PTHR45701:SF3
organism: Caenorhabditis elegans

uniprot Q3KRE3 483
type: UnificationXref
id: Q3KRE3
db: uniprot

uniprot Q9LMG8 325
type: UnificationXref
id: Q9LMG8
db: uniprot

axon terminus
type: CellularLocationVocabulary
xref: GO GO:0043679 3

Metabotropic glutamate receptor 5
type: ProteinReference
xref: uniprot P41594 159
xref: PTHR24060:SF30
organism: Homo sapiens

uniprot F6YN64 560
type: UnificationXref
id: F6YN64
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 520
xref: uniprot F1MBY1 546
xref: PTHR18966:SF99
organism: Bos taurus

NMDA s27 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NMDA
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_r31
controller: AC

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G485 570
xref: PTHR18966:SF38
organism: Monodelphis domestica

Complex (EAAT/Glutamate)
type: Complex
component stoichiometry: EAAT s15 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glutamate s127 sa15 STOICHIOMETRY ID COMPLEX
component: Glutamate
component: EAAT
feature: COMPLEX BINDING FEATURE s109 a114 655
feature: COMPLEX BINDING FEATURE s109 a114 657
cellular location: axon terminus

G-Protein
type: ProteinReference
xref: P01045
standard name: Gi-protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group III pathway.PROTEIN.GENERIC.G-Protein
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: Guanine nucleotide-binding protein beta subunit
member entity reference: Guanine nucleotide-binding protein G(K) subunit alpha
member entity reference: G protein subunit alpha i1
member entity reference: G protein subunit beta 4
member entity reference: Guanine nucleotide-binding protein G(k) subunit alpha
member entity reference: G protein alpha subunit Gi isoform X2
member entity reference: Gnb1l protein
member entity reference: G protein subunit alpha i2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
member entity reference: Guanine nucleotide-binding protein subunit beta-4
member entity reference: AGAP005912-PA
member entity reference: AGAP001506-PA
member entity reference: AGAP005904-PA
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: THO complex subunit, putative
member entity reference: Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
member entity reference: AGAP005911-PA
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
member entity reference: G protein subunit beta 5
member entity reference: Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
member entity reference: Guanine nucleotide-binding protein subunit beta-5
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-2
member entity reference: G protein subunit beta 3

HETERODIMER_ASSOCIATION_LEFT__SNARE_Complex-_Ca2_PLUS_-RIGHT__Complex__SNARE_Complex_Ca2_PLUS__-_r63
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 680
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 682
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 681
left: Ca2+
left: SNARE Complex
interaction type: HETERODIMER_ASSOCIATION
right: Complex (SNARE Complex/Ca2+)

Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
type: ProteinReference
xref: uniprot F1QEC8 21
xref: PTHR11635:SF129
organism: Danio rerio

uniprot Q14957 209
type: UnificationXref
id: Q14957
db: uniprot

Glutamate receptor ionotropic, NMDA3A
type: ProteinReference
evidence: Evidence 173
evidence: Evidence 168
xref: uniprot A2AIR5 172
xref: PTHR18966:SF397
organism: Mus musculus

Syntaxin-1A
type: ProteinReference
xref: uniprot Q16623 307
xref: PTHR19957:SF84
organism: Homo sapiens

uniprot Q7PXF7 95
type: UnificationXref
id: Q7PXF7
db: uniprot

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot O70404 281
xref: PTHR45701:SF7
organism: Mus musculus

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot F6Z5I2 265
xref: PTHR45701:SF7
organism: Monodelphis domestica

uniprot F7G7I9 420
type: UnificationXref
id: F7G7I9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HPP3 572
xref: PTHR18966:SF351
organism: Macaca mulatta

uniprot C7G3L5 540
type: UnificationXref
id: C7G3L5
db: uniprot

PARTICIPANT STOICHIOMETRY r65 675
type: Stoichiometry
physical entity: EAAT
stoichiometric coefficient: 1.0

uniprot P36408 452
type: UnificationXref
id: P36408
db: uniprot

PARTICIPANT STOICHIOMETRY r65 677
type: Stoichiometry
physical entity: Complex (EAAT/Glutamate)
stoichiometric coefficient: 1.0

Ca2 PLUS s14 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r65 676
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PTHR18966:SF397
type: RelationshipXref
id: PTHR18966:SF397
db: PANTHER Family
relationship type: By Homology

PTHR18966:SF391
type: RelationshipXref
id: PTHR18966:SF391
db: PANTHER Family
relationship type: By Homology

uniprot P68182 81
type: UnificationXref
id: P68182
db: uniprot

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
type: ProteinReference
xref: uniprot Q6DBV8 91
xref: PTHR24353:SF135
organism: Danio rerio

Complex (mGluR4/6/ 7/8/ G-Protein/GDP)
type: Complex
component stoichiometry: mGluR4 6 7 8 s6 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s7 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s8 sa7 STOICHIOMETRY ID COMPLEX
component: GDP
component: mGluR4/6/7/8
component: G-Protein
feature: COMPLEX BINDING FEATURE s75 a85 649
feature: COMPLEX BINDING FEATURE s75 a85 645
feature: COMPLEX BINDING FEATURE s75 a85 647
cellular location: axon terminus

PTHR18966:SF385
type: RelationshipXref
id: PTHR18966:SF385
db: PANTHER Family
relationship type: By Homology

PTHR18966:SF382
type: RelationshipXref
id: PTHR18966:SF382
db: PANTHER Family
relationship type: By Homology

uniprot P61264 293
type: UnificationXref
id: P61264
db: uniprot

Vglut
type: Protein
entity reference: Vglut
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa16 626
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

Glutamate ionotropic receptor NMDA type subunit 3A
type: ProteinReference
evidence: Evidence 173
evidence: Evidence 168
xref: uniprot E1BK87 175
xref: PTHR18966:SF397
organism: Bos taurus

G protein subunit alpha i2
type: ProteinReference
xref: uniprot H2QMN4 429
organism: Pan troglodytes

PTHR18966:SF377
type: RelationshipXref
id: PTHR18966:SF377
db: PANTHER Family
relationship type: By Homology

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa7 650
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r71 696
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

uniprot A0A286YAY2 527
type: UnificationXref
id: A0A286YAY2
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r62
control type: ACTIVATION
controller: Ca2+

PARTICIPANT STOICHIOMETRY r71 695
type: Stoichiometry
physical entity: mGluR 1/5
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r71 697
type: Stoichiometry
physical entity: Complex (mGluR 1/5/ Glutamate)
stoichiometric coefficient: 1.0

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot O95721 283
organism: Homo sapiens

uniprot B7Q3T6 375
type: UnificationXref
id: B7Q3T6
db: uniprot

uniprot P54313 461
type: UnificationXref
id: P54313
db: uniprot

PTHR11662:SF29
type: RelationshipXref
id: PTHR11662:SF29
db: PANTHER Family
relationship type: By Homology

uniprot D7RVR6 116
type: UnificationXref
id: D7RVR6
db: uniprot

DISSOCIATION
type: RelationshipTypeVocabulary

Metabotropic glutamate receptor 5
type: ProteinReference
xref: uniprot P31424 158
xref: PTHR24060:SF30
organism: Rattus norvegicus

uniprot G3V8K2 423
type: UnificationXref
id: G3V8K2
db: uniprot

Si:dkey-183j2.10
type: ProteinReference
xref: PTHR18966:SF417
xref: uniprot E7F5R2 545
organism: Danio rerio

uniprot Q3ZB92 87
type: UnificationXref
id: Q3ZB92
db: uniprot

uniprot Q80SZ7 508
type: UnificationXref
id: Q80SZ7
db: uniprot

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF67
xref: uniprot F1Q0W8 120
organism: Canis lupus familiaris

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa27 620
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50150 455
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot P50151 456
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot P50154 458
xref: PTHR13809:SF28
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50153 457
organism: Mus musculus

G Protein s11 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

Vesicle transport through interaction with t-SNAREs homolog 1A
type: ProteinReference
xref: uniprot Q96AJ9 322
xref: PTHR21230:SF62
organism: Homo sapiens

PTHR18966:SF361
type: RelationshipXref
id: PTHR18966:SF361
db: PANTHER Family
relationship type: By Homology

PTHR18966:SF364
type: RelationshipXref
id: PTHR18966:SF364
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__NMDA-_Glutamate-RIGHT__Complex__NMDA_Glutamate_-_r72
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 694
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 693
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 692
left: NMDA
left: Glutamate
interaction type: HETERODIMER_ASSOCIATION
right: Complex (NMDA/Glutamate)

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot Q01386 83
organism: Neurospora crassa

uniprot E2QUL1 176
type: UnificationXref
id: E2QUL1
db: uniprot

uniprot F1QEC8 21
type: UnificationXref
id: F1QEC8
db: uniprot

uniprot A0A1D5PCI4 5
type: UnificationXref
id: A0A1D5PCI4
db: uniprot

uniprot P30671 451
type: UnificationXref
id: P30671
db: uniprot

PTHR18966:SF351
type: RelationshipXref
id: PTHR18966:SF351
db: PANTHER Family
relationship type: By Homology

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P27791 71
organism: Rattus norvegicus

PTHR18966:SF38
type: RelationshipXref
id: PTHR18966:SF38
db: PANTHER Family
relationship type: By Homology

PTHR18966:SF36
type: RelationshipXref
id: PTHR18966:SF36
db: PANTHER Family
relationship type: By Homology

SNARE Complex
type: Protein
entity reference: SNARE Complex
feature: SNARE Complex s13 sa12 rs1
feature: ACTIVE 106
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa12 610
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q9BV40 323
organism: Homo sapiens

uniprot F7H6T2 33
type: UnificationXref
id: F7H6T2
db: uniprot

uniprot F7CXD0 410
type: UnificationXref
id: F7CXD0
db: uniprot

Metabotropic glutamate receptor 5 isoform a
type: ProteinReference
xref: uniprot F6SR09 156
xref: PTHR24060:SF30
organism: Macaca mulatta

Soluble NSF attachment protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot P83351 303
organism: Caenorhabditis elegans

EAAT
type: Protein
entity reference: EAAT
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa14 656
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa11 640
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Prkar1a protein
type: ProteinReference
xref: uniprot Q5I0F6 89
xref: PTHR11635:SF129
organism: Danio rerio

uniprot F7B4C1 565
type: UnificationXref
id: F7B4C1
db: uniprot

GO GO:0043679 3
type: UnificationXref
id: GO:0043679
db: GO

PARTICIPANT STOICHIOMETRY r73 689
type: Stoichiometry
physical entity: A/K
stoichiometric coefficient: 1.0

Complex (mGluR4/6/ 7/8/ Glutamate/G-Protein/ GDP)
type: Complex
component stoichiometry: G Protein s11 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: mGluR4 6 7 8 s9 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s12 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glutamate s10 sa9 STOICHIOMETRY ID COMPLEX
component: mGluR4/6/7/8
component: GDP
component: G-Protein
component: Glutamate
feature: COMPLEX BINDING FEATURE s101 a106 637
feature: COMPLEX BINDING FEATURE s101 a106 633
feature: COMPLEX BINDING FEATURE s101 a106 639
feature: COMPLEX BINDING FEATURE s101 a106 635
cellular location: axon terminus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63219 477
organism: Rattus norvegicus

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot F6Q503 22
organism: Macaca mulatta

uniprot Q8JZR4 152
type: UnificationXref
id: Q8JZR4
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 476
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63217 475
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63216 474
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 473
organism: Homo sapiens

uniprot Q5R1P0 211
type: UnificationXref
id: Q5R1P0
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63214 472
organism: Bos taurus

NMDA
type: ProteinReference
xref: P01039
standard name: N-methyl-D-aspartate Receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group III pathway.PROTEIN.ION_CHANNEL.NMDA
comment: ENTITY_REFERENCE_NOTES= Long Name: N-methyl-D-aspartate Receptor Synonym: NMDA,NMDA Receptor Accession: P01039
member entity reference: Glutamate ionotropic receptor NMDA type subunit 3A
member entity reference: Glutamate receptor ionotropic, NMDA 2A
member entity reference: Glutamate receptor ionotropic, NMDA 1
member entity reference: Uncharacterized protein
member entity reference: Glutamate receptor ionotropic, NMDA 2D
member entity reference: Glutamate receptor ionotropic, NMDA 3B
member entity reference: Glutamate ionotropic receptor NMDA type subunit 2A
member entity reference: Glutamate [NMDA] receptor subunit zeta-1 isoform NR1-3
member entity reference: Glutamate receptor ionotropic, NMDA 2B
member entity reference: NMDA class glutamate Receptor
member entity reference: Glutamate ionotropic receptor NMDA type subunit 1
member entity reference: AGAP001478-PA
member entity reference: Glutamate receptor ionotropic, NMDA 2C
member entity reference: N-methyl-D-aspartate receptor type 1 subunit
member entity reference: Glutamate receptor, ionotropic, N-methyl D-aspartate 1b
member entity reference: Glutamate receptor, ionotropic, N-methyl D-aspartate 1a
member entity reference: Glutamate receptor ionotropic, NMDA 3A
member entity reference: GRIN2B isoform 3
member entity reference: N-methyl D-aspartate receptor subtype 2B
member entity reference: Glutamate receptor ionotropic, NMDA3A
member entity reference: NMDA receptor 2, isoform C
member entity reference: Protein CBR-NMR-1
member entity reference: Glutamate [NMDA] receptor subunit 1

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q15KE4 480
organism: Danio rerio

Glutamate receptor 3.7
type: ProteinReference
xref: uniprot Q9SDQ4 606
xref: PTHR18966:SF427
organism: Arabidopsis thaliana

mGluR4 6 7 8 s6 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR4/6/7/8
stoichiometric coefficient: 1.0

uniprot H2Q1D9 426
type: UnificationXref
id: H2Q1D9
db: uniprot

uniprot P70579 360
type: UnificationXref
id: P70579
db: uniprot

uniprot Q9S7P9 328
type: UnificationXref
id: Q9S7P9
db: uniprot

PTHR19957:SF334
type: RelationshipXref
id: PTHR19957:SF334
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r73 690
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r73 691
type: Stoichiometry
physical entity: Complex (A/K/ Glutamate)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
evidence: Evidence 169
evidence: Evidence 168
evidence: Evidence 171
evidence: Evidence 170
xref: PTHR18966:SF407
xref: uniprot A0A1D5QE40 167
organism: Macaca mulatta

Adenylate cyclase type 10
type: ProteinReference
xref: uniprot Q9Z286 341
xref: PTHR16305:SF28
organism: Rattus norvegicus

uniprot F6YLB3 184
type: UnificationXref
id: F6YLB3
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P04897 437
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RGI5 385
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P04899 438
organism: Homo sapiens

Synaptobrevin
type: ProteinReference
xref: uniprot P18489 284
xref: PTHR45701:SF10
organism: Drosophila melanogaster

uniprot P30625 72
type: UnificationXref
id: P30625
db: uniprot

ncbitaxon 9598 36
type: UnificationXref
id: 9598
db: ncbitaxon

SNAP25 homologous protein SNAP29
type: ProteinReference
xref: uniprot Q9SD96 329
organism: Arabidopsis thaliana

ncbitaxon 7955 10
type: UnificationXref
id: 7955
db: ncbitaxon

TRANSPORT
type: RelationshipTypeVocabulary

DISSOCIATION_LEFT__GTP-_Complex__mGluR4_6__7_8__Glutamate_G_Protein__GDP_-RIGHT__Complex__mGluR4_6__7_8__Glutamate_-_Complex__GTP_G_Protein_-_GDP-_r57
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 709
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 706
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 708
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 707
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 705
left: GTP
left: Complex (mGluR4/6/ 7/8/ Glutamate/G-Protein/ GDP)
interaction type: DISSOCIATION
right: Complex (mGluR4/6/ 7/8/ Glutamate)
right: GDP
right: Complex (GTP/G-Protein)

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 373

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P17343 445
organism: Caenorhabditis elegans

uniprot A8XJJ7 114
type: UnificationXref
id: A8XJJ7
db: uniprot

uniprot F7G485 570
type: UnificationXref
id: F7G485
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3SZ98 484
organism: Bos taurus

Synaptosomal-associated protein 25-A
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q5TZ66 316
organism: Danio rerio

Metabotropic glutamate receptor 1
type: ProteinReference
xref: uniprot Q13255 225
xref: PTHR24060:SF29
organism: Homo sapiens

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A5PEW5 252
xref: PTHR19305:SF14
organism: Caenorhabditis elegans

uniprot P63215 473
type: UnificationXref
id: P63215
db: uniprot

uniprot G5EGQ9 188
type: UnificationXref
id: G5EGQ9
db: uniprot

uniprot A0A1D5PHB3 521
type: UnificationXref
id: A0A1D5PHB3
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 7

uniprot F6XHP0 402
type: UnificationXref
id: F6XHP0
db: uniprot

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot P00514 44
xref: PTHR11635:SF129
organism: Bos taurus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P00515 45
organism: Bos taurus

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P00517 46
xref: PTHR24353:SF82
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EZT2 415
organism: Macaca mulatta

uniprot Q00975 239
type: UnificationXref
id: Q00975
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 27

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7AE17 432
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 380
organism: Gallus gallus

uniprot Q5TZ66 316
type: UnificationXref
id: Q5TZ66
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: uniprot P05987 50
xref: PTHR11635:SF152
organism: Dictyostelium discoideum

uniprot Q28H40 482
type: UnificationXref
id: Q28H40
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F6VUT7 261
xref: PTHR19305:SF5
organism: Ornithorhynchus anatinus

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: PTHR45628:SF6
xref: uniprot O55017 236
organism: Mus musculus

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 171
xref: uniprot Q13224 208
xref: PTHR18966:SF382
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot H2RI77 41
xref: PTHR24353:SF128
organism: Pan troglodytes

uniprot A0A0R4IFU7 107
type: UnificationXref
id: A0A0R4IFU7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 419
organism: Monodelphis domestica

Excitatory amino acid transporter 5
type: ProteinReference
xref: PTHR11958:SF22
xref: uniprot O00341 131
organism: Homo sapiens

GTP s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Ca2+
type: Protein
entity reference: Ca2+
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot E2RGI5 385
type: UnificationXref
id: E2RGI5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1P0L4 550
xref: PTHR18966:SF174
organism: Gallus gallus

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P08752 439
organism: Mus musculus

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot P08754 441
organism: Homo sapiens

uniprot P62879 466
type: UnificationXref
id: P62879
db: uniprot

AGAP004940-PA
type: ProteinReference
xref: PTHR11635:SF162
xref: uniprot Q7PPI8 93
organism: Anopheles gambiae

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot P08753 440
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r59
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 702
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 701
left: PKA
interaction type: STATE_TRANSITION
right: PKA

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa23 616
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9ERB0 324
organism: Mus musculus

uniprot P91645 237
type: UnificationXref
id: P91645
db: uniprot

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF22
xref: uniprot F1MUT8 118
organism: Bos taurus

uniprot P35438 198
type: UnificationXref
id: P35438
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 514
organism: Homo sapiens

uniprot F7D9M6 335
type: UnificationXref
id: F7D9M6
db: uniprot

GDP s12 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot F6T8S6 182
type: UnificationXref
id: F6T8S6
db: uniprot

uniprot F7BDN8 566
type: UnificationXref
id: F7BDN8
db: uniprot

uniprot E9FUX0 388
type: UnificationXref
id: E9FUX0
db: uniprot

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 171
xref: PTHR18966:SF382
xref: uniprot Q00960 201
organism: Rattus norvegicus

Glutamate receptor ionotropic, NMDA 2C
type: ProteinReference
evidence: Evidence 192
evidence: Evidence 193
xref: uniprot Q00961 202
xref: PTHR18966:SF361
organism: Rattus norvegicus

Excitatory amino acid transporter 5
type: ProteinReference
xref: PTHR11958:SF22
xref: uniprot Q8JZR4 152
organism: Mus musculus

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 326

Glutamate ionotropic receptor NMDA type subunit 3A
type: ProteinReference
evidence: Evidence 173
evidence: Evidence 168
xref: uniprot H2QZZ2 190
xref: PTHR18966:SF397
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P18851 446
organism: Saccharomyces cerevisiae

Gbeta5
type: ProteinReference
xref: uniprot Q9W3J1 516
organism: Drosophila melanogaster

PTHR45701:SF6
type: RelationshipXref
id: PTHR45701:SF6
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF7
type: RelationshipXref
id: PTHR45701:SF7
db: PANTHER Family
relationship type: By Homology

G protein subunit gamma 5
type: ProteinReference
xref: uniprot H2PZA6 424
organism: Pan troglodytes

PTHR45701:SF5
type: RelationshipXref
id: PTHR45701:SF5
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF3
type: RelationshipXref
id: PTHR45701:SF3
db: PANTHER Family
relationship type: By Homology

Glutamate receptor ionotropic, NMDA 2A
type: ProteinReference
evidence: Evidence 192
evidence: Evidence 193
evidence: Evidence 197
evidence: Evidence 196
xref: PTHR18966:SF407
xref: uniprot Q00959 200
organism: Rattus norvegicus

PTHR45701:SF1
type: RelationshipXref
id: PTHR45701:SF1
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF157
xref: uniprot A0A1D5RJF9 524
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot Q9UK08 515
organism: Homo sapiens

Vesicle transport through interaction with t-SNAREs homolog 1A
type: ProteinReference
xref: uniprot O89116 282
xref: PTHR21230:SF62
organism: Mus musculus

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 632
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Glutamate metabotropic receptor 5
type: ProteinReference
xref: PTHR24060:SF30
xref: uniprot J9JH96 157
organism: Canis lupus familiaris

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: PTHR45628:SF6
xref: uniprot Q00975 239
organism: Homo sapiens

P01035
type: UnificationXref
id: P01035
db: PANTHER Pathway Component

P01037
type: UnificationXref
id: P01037
db: PANTHER Pathway Component

P01036
type: UnificationXref
id: P01036
db: PANTHER Pathway Component

uniprot F6VM87 260
type: UnificationXref
id: F6VM87
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 10

uniprot P12368 57
type: UnificationXref
id: P12368
db: uniprot

A/K
type: ProteinReference
xref: P01046
standard name: AMPA/Kainate Receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group III pathway.PROTEIN.ION_CHANNEL.A/K
comment: ENTITY_REFERENCE_NOTES= Long Name: AMPA/Kainate Receptor Synonym: A/K,AK,AMPA,AMPA Receptor,KA receptor,Kainate,Kainate Receptor Accession: P01046
member entity reference: Uncharacterized protein
member entity reference: Glutamate receptor 3.2
member entity reference: Glutamate receptor ionotropic, kainate 1
member entity reference: Glutamate receptor, ionotropic, kainate 5
member entity reference: Glutamate receptor 3
member entity reference: Glutamate receptor, ionotropic, kainate 1b
member entity reference: Glutamate ionotropic receptor AMPA type subunit 2
member entity reference: Glutamate receptor 2
member entity reference: Glutamate receptor ionotropic, kainate 3
member entity reference: Ionotropic glutamate receptor AMPA 1
member entity reference: Glutamate ionotropic receptor kainate type subunit 2
member entity reference: GRIK2 isoform 3
member entity reference: Glutamate receptor ionotropic, kainate 4
member entity reference: Glutamate receptor, ionotropic, kainate 1
member entity reference: Glutamate receptor ionotropic, kainate 2
member entity reference: Glutamate ionotropic receptor kainate type subunit 5
member entity reference: GRIK1 isoform 7
member entity reference: GRIA1 isoform 11
member entity reference: Glutamate receptor IB, isoform B
member entity reference: Glutamate receptor, ionotropic, AMPA 4b
member entity reference: GRIA3 isoform 2
member entity reference: Glutamate ionotropic receptor AMPA type subunit 4
member entity reference: Glutamate ionotropic receptor kainate type subunit 1
member entity reference: Probable glutamate receptor
member entity reference: Glutamate receptor, ionotropic, AMPA 4a
member entity reference: Glutamate receptor 3.7
member entity reference: Glutamate ionotropic receptor AMPA type subunit 3
member entity reference: Glutamate receptor ionotropic, kainate 5
member entity reference: Glutamate receptor, ionotropic, AMPA 3b
member entity reference: Glutamate ionotropic receptor kainate type subunit 3
member entity reference: GRIA2 isoform 6
member entity reference: Glutamate receptor, ionotropic, AMPA 3a
member entity reference: Glutamate receptor 4
member entity reference: Glutamate receptor 1
member entity reference: Protein CBR-GLR-1
member entity reference: Si:dkey-183j2.10
member entity reference: Glutamate receptor, ionotropic, AMPA 3
member entity reference: Glutamate receptor, ionotropic, AMPA 2b

uniprot A0A2I3T979 530
type: UnificationXref
id: A0A2I3T979
db: uniprot

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q17QQ3 308
xref: PTHR19305:SF5
organism: Bos taurus

Syntaxin 1B
type: ProteinReference
xref: uniprot F6WJB1 262
xref: PTHR19957:SF334
organism: Monodelphis domestica

SNARE Complex s61 a107 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF22
xref: uniprot D3ZT83 115
organism: Rattus norvegicus

Glutamate receptor, ionotropic, AMPA 4b
type: ProteinReference
xref: PTHR18966:SF100
xref: uniprot A0A2R8QDR4 533
organism: Danio rerio

uniprot P63218 476
type: UnificationXref
id: P63218
db: uniprot

uniprot F6T507 124
type: UnificationXref
id: F6T507
db: uniprot

uniprot Q0V7N0 304
type: UnificationXref
id: Q0V7N0
db: uniprot

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF22
xref: uniprot F6YEB6 125
organism: Macaca mulatta

uniprot E9AFM1 16
type: UnificationXref
id: E9AFM1
db: uniprot

uniprot A0A2R8QDR4 533
type: UnificationXref
id: A0A2R8QDR4
db: uniprot

uniprot K7AEL3 43
type: UnificationXref
id: K7AEL3
db: uniprot

uniprot A8XW88 11
type: UnificationXref
id: A8XW88
db: uniprot

uniprot F7H624 129
type: UnificationXref
id: F7H624
db: uniprot

uniprot Q9UK08 515
type: UnificationXref
id: Q9UK08
db: uniprot

Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
type: ProteinReference
xref: uniprot Q6DH55 494
organism: Danio rerio

uniprot F6UFJ7 259
type: UnificationXref
id: F6UFJ7
db: uniprot

uniprot Q7PXP3 501
type: UnificationXref
id: Q7PXP3
db: uniprot

Glutamate receptor ionotropic, kainate 5
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot Q61626 602
organism: Mus musculus

uniprot F6Y4M4 163
type: UnificationXref
id: F6Y4M4
db: uniprot

uniprot Q5ZM91 90
type: UnificationXref
id: Q5ZM91
db: uniprot

Amino acid transporter
type: ProteinReference
xref: uniprot E1JHQ6 117
xref: PTHR11958:SF99
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r59 702
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 701
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q62442 317
organism: Mus musculus

uniprot P34099 76
type: UnificationXref
id: P34099
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 58

Glutamate ionotropic receptor kainate type subunit 2
type: ProteinReference
xref: PTHR18966:SF38
xref: uniprot F6TDQ6 556
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r56 711
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r56 712
type: Stoichiometry
physical entity: Complex (mGluR4/6/ 7/8/ Glutamate/G-Protein/ GDP)
stoichiometric coefficient: 1.0

uniprot Q6DBV8 91
type: UnificationXref
id: Q6DBV8
db: uniprot

uniprot F6WJB1 262
type: UnificationXref
id: F6WJB1
db: uniprot

uniprot Q9CXP8 512
type: UnificationXref
id: Q9CXP8
db: uniprot

uniprot P39087 584
type: UnificationXref
id: P39087
db: uniprot

uniprot F7AGS3 562
type: UnificationXref
id: F7AGS3
db: uniprot

uniprot F7HPP3 572
type: UnificationXref
id: F7HPP3
db: uniprot

PARTICIPANT STOICHIOMETRY r56 710
type: Stoichiometry
physical entity: Complex (mGluR4/6/ 7/8/ G-Protein/GDP)
stoichiometric coefficient: 1.0

uniprot P63026 299
type: UnificationXref
id: P63026
db: uniprot

uniprot Q5BK52 88
type: UnificationXref
id: Q5BK52
db: uniprot

uniprot Q68EF4 365
type: UnificationXref
id: Q68EF4
db: uniprot

uniprot F6ZIZ9 406
type: UnificationXref
id: F6ZIZ9
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q0V7N0 304
organism: Bos taurus

uniprot A0A1D5QET0 161
type: UnificationXref
id: A0A1D5QET0
db: uniprot

GRIK1 protein
type: ProteinReference
xref: PTHR18966:SF36
xref: uniprot A2VE57 537
organism: Bos taurus

uniprot F6PGX6 181
type: UnificationXref
id: F6PGX6
db: uniprot

uniprot A0A3Q1LZY8 229
type: UnificationXref
id: A0A3Q1LZY8
db: uniprot

uniprot Q13255 225
type: UnificationXref
id: Q13255
db: uniprot

uniprot F6T0T9 28
type: UnificationXref
id: F6T0T9
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 390

Voltage-dependent R-type calcium channel subunit alpha-1E
type: ProteinReference
xref: uniprot Q61290 244
xref: PTHR45628:SF5
organism: Mus musculus

Glutamate ionotropic receptor AMPA type subunit 2
type: ProteinReference
xref: PTHR18966:SF99
xref: uniprot F1PE26 551
organism: Canis lupus familiaris

uniprot Q15836 306
type: UnificationXref
id: Q15836
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot A0A1D5QIS2 248
organism: Macaca mulatta

Glutamate metabotropic receptor 6
type: ProteinReference
xref: uniprot F1P8E3 349
xref: PTHR24060:SF24
organism: Canis lupus familiaris

Glutamate s24 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r70 700
type: Stoichiometry
physical entity: Complex (mGluR 5/Glutamate)
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot P34099 76
xref: PTHR24353:SF37
organism: Dictyostelium discoideum

Voltage-dependent R-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot A0A1D5Q7C3 226
xref: PTHR45628:SF5
organism: Macaca mulatta

cAMP-dependent protein kinase catalytic subunit 3
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot P16912 65
organism: Drosophila melanogaster

uniprot E1C795 381
type: UnificationXref
id: E1C795
db: uniprot

uniprot P12369 59
type: UnificationXref
id: P12369
db: uniprot

ncbitaxon 13616 27
type: UnificationXref
id: 13616
db: ncbitaxon

AC
type: Protein
entity reference: AC
feature: ACTIVE 106
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P16520 444
organism: Homo sapiens

cAMP-dependent protein kinase type I regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P16905 64
organism: Drosophila melanogaster

Protein kinase, cAMP-dependent, catalytic, beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot Q3ZB92 87
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DGZ5 493
organism: Danio rerio

Protein kinase A catalytic subunit isoform 1
type: ProteinReference
xref: uniprot Q9GNR4 105
xref: PTHR24353:SF67
organism: Leishmania major

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot E2RFB5 543
organism: Canis lupus familiaris

uniprot Q5ZJ03 489
type: UnificationXref
id: Q5ZJ03
db: uniprot

Glutamate receptor 1
type: ProteinReference
xref: PTHR18966:SF297
xref: uniprot P34299 582
organism: Caenorhabditis elegans

ncbitaxon 9606 55
type: UnificationXref
id: 9606
db: ncbitaxon

PTHR18966:SF417
type: RelationshipXref
id: PTHR18966:SF417
db: PANTHER Family
relationship type: By Homology

Complex (SNARE Complex/Ca2+)
type: Complex
component stoichiometry: Ca2 PLUS s14 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: SNARE Complex s13 sa12 STOICHIOMETRY ID COMPLEX
component: SNARE Complex
component: Ca2+
feature: COMPLEX BINDING FEATURE s106 a111 609
feature: COMPLEX BINDING FEATURE s106 a111 611
cellular location: synaptic vesicle

PTHR24060:SF98
type: RelationshipXref
id: PTHR24060:SF98
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r64 679
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 678
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

uniprot D3ZT83 115
type: UnificationXref
id: D3ZT83
db: uniprot

Glutamate receptor, ionotropic, AMPA 3
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot F7AF72 561
organism: Xenopus tropicalis

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot F7FXA9 418
organism: Macaca mulatta

uniprot O89116 282
type: UnificationXref
id: O89116
db: uniprot

uniprot P51906 144
type: UnificationXref
id: P51906
db: uniprot

PTHR18966:SF407
type: RelationshipXref
id: PTHR18966:SF407
db: PANTHER Family
relationship type: By Homology

mGluR4/6/7/8
type: Protein
entity reference: mGluR4/6/7/8
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa8 634
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

PTHR18966:SF400
type: RelationshipXref
id: PTHR18966:SF400
db: PANTHER Family
relationship type: By Homology

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F5HMS4 257
xref: PTHR19305:SF14
organism: Anopheles gambiae

Ca2+
type: ProteinReference
xref: P01041
standard name: Calcium Channel
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES= Long Name: Calcium Channel Synonym: Ca2+ channel Accession: P01041
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group III pathway.PROTEIN.ION_CHANNEL.Ca_super_2+
member entity reference: Voltage-dependent L-type calcium channel subunit beta-1
member entity reference: Voltage-dependent N-type calcium channel subunit alpha-1B
member entity reference: Voltage-dependent N-type calcium channel subunit alpha
member entity reference: Voltage-dependent calcium channel type A subunit alpha-1
member entity reference: AGAP002578-PB
member entity reference: Voltage-dependent R-type calcium channel subunit alpha-1E
member entity reference: Calcium voltage-gated channel auxiliary subunit beta 1
member entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha
member entity reference: Voltage-dependent R-type calcium channel subunit alpha
member entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
member entity reference: Protein CBR-UNC-2 (Fragment)
member entity reference: Uncharacterized protein

uniprot F7F580 416
type: UnificationXref
id: F7F580
db: uniprot

uniprot E2RRA1 13
type: UnificationXref
id: E2RRA1
db: uniprot

Excitatory amino acid transporter 1
type: ProteinReference
xref: uniprot P46411 142
xref: PTHR11958:SF24
organism: Bos taurus

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF89
xref: uniprot A8XJJ7 114
organism: Caenorhabditis briggsae

uniprot Q7T374 97
type: UnificationXref
id: Q7T374
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_r58
controller: Complex (GTP/G-Protein)

ncbitaxon 10116 58
type: UnificationXref
id: 10116
db: ncbitaxon

Excitatory amino acid transporter 3
type: ProteinReference
xref: PTHR11958:SF97
xref: uniprot P43005 140
organism: Homo sapiens

Vglut s17 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Vglut
stoichiometric coefficient: 1.0

Excitatory amino acid transporter 2
type: ProteinReference
xref: uniprot P43004 139
xref: PTHR11958:SF93
organism: Homo sapiens

Excitatory amino acid transporter 1
type: ProteinReference
xref: uniprot P43003 138
xref: PTHR11958:SF24
organism: Homo sapiens

Excitatory amino acid transporter 2
type: ProteinReference
xref: uniprot P43006 141
xref: PTHR11958:SF93
organism: Mus musculus

uniprot F7FD32 417
type: UnificationXref
id: F7FD32
db: uniprot

GRM4 isoform 4
type: ProteinReference
xref: uniprot C7G3M9 343
xref: PTHR24060:SF23
organism: Pan troglodytes

Glutamate metabotropic receptor 6
type: ProteinReference
xref: uniprot C7G3N0 344
xref: PTHR24060:SF24
organism: Pan troglodytes

PTHR10218:SF227
type: RelationshipXref
id: PTHR10218:SF227
db: PANTHER Family
relationship type: By Homology

uniprot O14610 434
type: UnificationXref
id: O14610
db: uniprot

PTHR18966:SF427
type: RelationshipXref
id: PTHR18966:SF427
db: PANTHER Family
relationship type: By Homology

PTHR18966:SF422
type: RelationshipXref
id: PTHR18966:SF422
db: PANTHER Family
relationship type: By Homology

uniprot P63044 301
type: UnificationXref
id: P63044
db: uniprot

uniprot Q7QGG0 320
type: UnificationXref
id: Q7QGG0
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot Q9Z2P6 334
xref: PTHR19305:SF9
organism: Rattus norvegicus

uniprot Q96PN6 340
type: UnificationXref
id: Q96PN6
db: uniprot

uniprot A0A1D5Q7C3 226
type: UnificationXref
id: A0A1D5Q7C3
db: uniprot

uniprot A0A2I3S1J9 528
type: UnificationXref
id: A0A2I3S1J9
db: uniprot

uniprot P07278 52
type: UnificationXref
id: P07278
db: uniprot

PTHR10218:SF230
type: RelationshipXref
id: PTHR10218:SF230
db: PANTHER Family
relationship type: By Homology

DISSOCIATION_LEFT__Complex__EAAT_Glutamate_-RIGHT__Glutamate-_EAAT-_r66
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 673
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 674
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 672
left: Complex (EAAT/Glutamate)
interaction type: DISSOCIATION
right: Glutamate
right: EAAT

Metabotropic glutamate receptor 1
type: ProteinReference
xref: uniprot P97772 224
xref: PTHR24060:SF29
organism: Mus musculus

Glutamate receptor ionotropic, kainate 4
type: ProteinReference
xref: uniprot Q8BMF5 604
xref: PTHR18966:SF171
organism: Mus musculus

Voltage-dependent P/Q-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot F1N1E0 231
xref: PTHR10037:SF290
organism: Bos taurus

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot P10644 54
xref: PTHR11635:SF129
organism: Homo sapiens

uniprot P63216 474
type: UnificationXref
id: P63216
db: uniprot

ncbitaxon 9258 122
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot F1NMB0 179
type: UnificationXref
id: F1NMB0
db: uniprot

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q922R0 103
organism: Mus musculus

Metabotropic glutamate receptor 6
type: ProteinReference
xref: uniprot Q5NCH9 363
xref: PTHR24060:SF24
organism: Mus musculus

Glutamate metabotropic receptor 4
type: ProteinReference
xref: uniprot E1B965 345
xref: PTHR24060:SF23
organism: Bos taurus

Glutamate receptor ionotropic, kainate 4
type: ProteinReference
xref: uniprot Q01812 591
xref: PTHR18966:SF171
organism: Rattus norvegicus

Adenylate/guanylate cyclase
type: ProteinReference
xref: PTHR16305:SF28
xref: uniprot Q8EZ52 339
organism: Leptospira interrogans

uniprot P43003 138
type: UnificationXref
id: P43003
db: uniprot

uniprot O14775 435
type: UnificationXref
id: O14775
db: uniprot

uniprot E2RHY4 386
type: UnificationXref
id: E2RHY4
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot O14610 434
xref: PTHR13809:SF28
organism: Homo sapiens

uniprot E7F5R2 545
type: UnificationXref
id: E7F5R2
db: uniprot

GRIK1 isoform 7
type: ProteinReference
xref: PTHR18966:SF36
xref: uniprot A0A2I3T979 530
organism: Pan troglodytes

uniprot E9GNI4 19
type: UnificationXref
id: E9GNI4
db: uniprot

uniprot F6PVT7 397
type: UnificationXref
id: F6PVT7
db: uniprot

uniprot Q96AJ9 322
type: UnificationXref
id: Q96AJ9
db: uniprot

PARTICIPANT STOICHIOMETRY r58 703
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 704
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 443
organism: Bos taurus

Glutamate ionotropic receptor NMDA type subunit 2A
type: ProteinReference
evidence: Evidence 169
evidence: Evidence 168
evidence: Evidence 171
evidence: Evidence 170
xref: PTHR18966:SF407
xref: uniprot F6YLB3 184
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot F7H6T2 33
organism: Macaca mulatta

mGluR 1/5
type: ProteinReference
xref: P01040
standard name: Metabotropic Glutamate Receptor 1 and 5
comment: ENTITY_REFERENCE_NOTES= Long Name: Metabotropic Glutamate Receptor 1, Metabotropic Glutamate Receptor 5 Synonym: GRM1,GRM5,mGlu1,mGlu5,mGluR1,mGluR5 Accession: P01040
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group III pathway.PROTEIN.RECEPTOR.mGluR 1/5
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Glutamate metabotropic receptor 1
member entity reference: Metabotropic glutamate receptor 1 isoform beta
member entity reference: Metabotropic glutamate receptor 1
member entity reference: Glutamate metabotropic receptor 5
member entity reference: Metabotropic glutamate receptor 5 isoform a
member entity reference: Metabotropic glutamate receptor 5
member entity reference: Uncharacterized protein

mGluR 5
type: Protein
entity reference: mGluR 5
feature: COMPLEX PARTICIPANT BINDING FEATURE s126 sa20 652
cellular location: Glia c8
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T7 422
organism: Macaca mulatta

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF97
xref: uniprot D7RVR6 116
organism: Danio rerio

uniprot A0A286YAM5 526
type: UnificationXref
id: A0A286YAM5
db: uniprot

uniprot F6YZA3 405
type: UnificationXref
id: F6YZA3
db: uniprot

Protein CBR-UNC-2 (Fragment)
type: ProteinReference
xref: PTHR45628:SF7
xref: uniprot A8WRW6 230
organism: Caenorhabditis briggsae

uniprot H9EQQ4 42
type: UnificationXref
id: H9EQQ4
db: uniprot

Protein kinase, X-linked
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q5BK52 88
organism: Rattus norvegicus

uniprot F6PQH1 121
type: UnificationXref
id: F6PQH1
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P43425 453
organism: Rattus norvegicus

uniprot Q9Z2W9 608
type: UnificationXref
id: Q9Z2W9
db: uniprot

uniprot P31321 73
type: UnificationXref
id: P31321
db: uniprot

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: uniprot Q9MZL7 246
xref: PTHR11824:SF17
organism: Bos taurus

uniprot F6ZDV3 126
type: UnificationXref
id: F6ZDV3
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Glutamate-RIGHT__Glutamate-_r64
control type: ACTIVATION
controller: Complex (SNARE Complex/Ca2+)

uniprot Q2KJD2 311
type: UnificationXref
id: Q2KJD2
db: uniprot

Protein kinase, cAMP-dependent, regulatory, type I, beta
type: ProteinReference
xref: PTHR11635:SF126
xref: uniprot Q08C49 85
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XWE8 403
organism: Monodelphis domestica

ncbitaxon 6945 376
type: UnificationXref
id: 6945
db: ncbitaxon

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot Q92356 321
organism: Schizosaccharomyces pombe

PTHR18966:SF497
type: RelationshipXref
id: PTHR18966:SF497
db: PANTHER Family
relationship type: By Homology

AGAP005904-PA
type: ProteinReference
xref: uniprot Q7Q6E0 505
xref: PTHR10218:SF310
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 171
xref: PTHR18966:SF382
xref: uniprot F1NMB0 179
organism: Gallus gallus

AGAP005911-PA
type: ProteinReference
xref: uniprot Q7Q6D4 504
organism: Anopheles gambiae

Voltage-dependent R-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot A0A2J8N6N1 228
xref: PTHR45628:SF5
organism: Pan troglodytes

uniprot G3N3K3 187
type: UnificationXref
id: G3N3K3
db: uniprot

uniprot H2RI77 41
type: UnificationXref
id: H2RI77
db: uniprot

AGAP005913-PA
type: ProteinReference
xref: uniprot Q7Q6D2 502
organism: Anopheles gambiae

AGAP005912-PA
type: ProteinReference
xref: uniprot Q7Q6D3 503
organism: Anopheles gambiae

Amino acid transporter
type: ProteinReference
xref: uniprot A0A0R4IFU7 107
xref: PTHR11958:SF93
organism: Danio rerio

Glutamate receptor ionotropic, NMDA 2C
type: ProteinReference
evidence: Evidence 192
evidence: Evidence 193
xref: uniprot Q01098 204
xref: PTHR18966:SF361
organism: Mus musculus

uniprot G2HIJ9 269
type: UnificationXref
id: G2HIJ9
db: uniprot

PTHR18966:SF488
type: RelationshipXref
id: PTHR18966:SF488
db: PANTHER Family
relationship type: By Homology

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 171
xref: PTHR18966:SF382
xref: uniprot Q01097 203
organism: Mus musculus

uniprot Q68ED2 364
type: UnificationXref
id: Q68ED2
db: uniprot

uniprot Q16623 307
type: UnificationXref
id: Q16623
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 122

uniprot A8WUE7 174
type: UnificationXref
id: A8WUE7
db: uniprot

PTHR13809:SF28
type: RelationshipXref
id: PTHR13809:SF28
db: PANTHER Family
relationship type: By Homology

Glutamate receptor, ionotropic, AMPA 2b
type: ProteinReference
evidence: Evidence 520
xref: PTHR18966:SF99
xref: uniprot A0A286YAM5 526
organism: Danio rerio

uniprot P05131 47
type: UnificationXref
id: P05131
db: uniprot

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF97
xref: uniprot H2R6U6 130
organism: Pan troglodytes

uniprot F6R6X5 351
type: UnificationXref
id: F6R6X5
db: uniprot

SNARE Complex
type: Protein
entity reference: SNARE Complex
feature: SNARE Complex s61 a107 rs1
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 3702 326
type: UnificationXref
id: 3702
db: ncbitaxon

Glutamate receptor ionotropic, NMDA 2D
type: ProteinReference
evidence: Evidence 192
evidence: Evidence 193
evidence: Evidence 194
xref: uniprot O15399 191
xref: PTHR18966:SF385
organism: Homo sapiens

uniprot H2QFK0 35
type: UnificationXref
id: H2QFK0
db: uniprot

PTHR24060:SF30
type: RelationshipXref
id: PTHR24060:SF30
db: PANTHER Family
relationship type: By Homology

Amino acid transporter
type: ProteinReference
xref: uniprot O18210 132
organism: Caenorhabditis elegans

uniprot Q922R0 103
type: UnificationXref
id: Q922R0
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Glutamate-_Vglut-RIGHT__Complex__Vglut_Glutamate_-_r67
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 669
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 671
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 670
left: Glutamate
left: Vglut
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Vglut/Glutamate)

uniprot E2RFB5 543
type: UnificationXref
id: E2RFB5
db: uniprot

uniprot Q63273 603
type: UnificationXref
id: Q63273
db: uniprot

Vesicular glutamate transporter 1
type: ProteinReference
xref: PTHR11662:SF29
xref: uniprot Q3TXX4 164
organism: Mus musculus

P01039
type: UnificationXref
id: P01039
db: PANTHER Pathway Component

P01038
type: UnificationXref
id: P01038
db: PANTHER Pathway Component

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 14

uniprot K7AE17 432
type: UnificationXref
id: K7AE17
db: uniprot

uniprot G0T3G6 573
type: UnificationXref
id: G0T3G6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NGS8 368
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VUY3 353
xref: PTHR24060:SF26
organism: Macaca mulatta

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 430
organism: Pan troglodytes

uniprot M9PHV5 575
type: UnificationXref
id: M9PHV5
db: uniprot

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa13 612
cellular location: synaptic vesicle
comment: SPECIES_TYPE=ION

PTHR24060:SF24
type: RelationshipXref
id: PTHR24060:SF24
db: PANTHER Family
relationship type: By Homology

PTHR24060:SF23
type: RelationshipXref
id: PTHR24060:SF23
db: PANTHER Family
relationship type: By Homology

uniprot Q61011 490
type: UnificationXref
id: Q61011
db: uniprot

VAMP3 isoform 1
type: ProteinReference
xref: uniprot G2HIJ9 269
xref: PTHR45701:SF6
organism: Pan troglodytes

PTHR24060:SF29
type: RelationshipXref
id: PTHR24060:SF29
db: PANTHER Family
relationship type: By Homology

uniprot P10644 54
type: UnificationXref
id: P10644
db: uniprot

P01040
type: UnificationXref
id: P01040
db: PANTHER Pathway Component

Glutamate ionotropic receptor kainate type subunit 1
type: ProteinReference
xref: PTHR18966:SF36
xref: uniprot F6S5B1 554
organism: Monodelphis domestica

PTHR24060:SF26
type: RelationshipXref
id: PTHR24060:SF26
db: PANTHER Family
relationship type: By Homology

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot E2R907 255
xref: PTHR19305:SF5
organism: Canis lupus familiaris

P01045
type: UnificationXref
id: P01045
db: PANTHER Pathway Component

P01046
type: UnificationXref
id: P01046
db: PANTHER Pathway Component

P01041
type: UnificationXref
id: P01041
db: PANTHER Pathway Component

P01042
type: UnificationXref
id: P01042
db: PANTHER Pathway Component

P01043
type: UnificationXref
id: P01043
db: PANTHER Pathway Component

P01044
type: UnificationXref
id: P01044
db: PANTHER Pathway Component

Excitatory amino acid transporter 2
type: ProteinReference
xref: uniprot P31596 137
xref: PTHR11958:SF93
organism: Rattus norvegicus

Glutamate ionotropic receptor AMPA type subunit 3
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot F6TYP9 557
organism: Ornithorhynchus anatinus

uniprot Q01812 591
type: UnificationXref
id: Q01812
db: uniprot

Protein CBR-GLR-1
type: ProteinReference
xref: PTHR18966:SF297
xref: uniprot A8XT20 538
organism: Caenorhabditis briggsae

uniprot A0A286Y9Q6 525
type: UnificationXref
id: A0A286Y9Q6
db: uniprot

Syntaxin-1B
type: ProteinReference
xref: PTHR19957:SF334
xref: uniprot P61265 294
organism: Rattus norvegicus

Syntaxin-1B
type: ProteinReference
xref: uniprot P61264 293
xref: PTHR19957:SF334
organism: Mus musculus

uniprot Q9W581 220
type: UnificationXref
id: Q9W581
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7GI54 421
organism: Monodelphis domestica

uniprot B1AS29 539
type: UnificationXref
id: B1AS29
db: uniprot

SNARE Complex s13 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SNARE Complex
stoichiometric coefficient: 1.0

SNAP25 homologous protein SNAP33
type: ProteinReference
xref: uniprot Q9S7P9 328
organism: Arabidopsis thaliana

uniprot P62881 468
type: UnificationXref
id: P62881
db: uniprot

GRIK3 isoform 1
type: ProteinReference
xref: uniprot C7G3L6 541
xref: PTHR18966:SF174
organism: Pan troglodytes

GRIK2 isoform 3
type: ProteinReference
xref: uniprot C7G3L5 540
xref: PTHR18966:SF38
organism: Pan troglodytes

A/K
type: Protein
entity reference: A/K
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa22 614
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR19957:SF84
type: RelationshipXref
id: PTHR19957:SF84
db: PANTHER Family
relationship type: By Homology

Glutamate receptor, ionotropic, N-methyl D-aspartate 1a
type: ProteinReference
evidence: Evidence 168
xref: PTHR18966:SF400
xref: uniprot E7F101 177
organism: Danio rerio

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: PTHR24353:SF133
xref: uniprot P51817 79
organism: Homo sapiens

Syntaxin-1B
type: ProteinReference
xref: PTHR19957:SF334
xref: uniprot P61266 295
organism: Homo sapiens

Syntaxin-1B
type: ProteinReference
xref: uniprot P61267 296
xref: PTHR19957:SF334
organism: Bos taurus

uniprot F6UBJ8 258
type: UnificationXref
id: F6UBJ8
db: uniprot

STX1A isoform 3
type: ProteinReference
xref: uniprot H2QUQ1 273
xref: PTHR19957:SF84
organism: Pan troglodytes

uniprot H2R6U6 130
type: UnificationXref
id: H2R6U6
db: uniprot

uniprot Q15878 243
type: UnificationXref
id: Q15878
db: uniprot

ncbitaxon 227321 314
type: UnificationXref
id: 227321
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 404
organism: Monodelphis domestica

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: uniprot P81900 82
xref: PTHR11635:SF162
organism: Drosophila melanogaster

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: PTHR24353:SF137
xref: uniprot P22612 69
organism: Homo sapiens

uniprot Q6PC54 319
type: UnificationXref
id: Q6PC54
db: uniprot

uniprot P61267 296
type: UnificationXref
id: P61267
db: uniprot

uniprot P60878 290
type: UnificationXref
id: P60878
db: uniprot

uniprot Q00961 202
type: UnificationXref
id: Q00961
db: uniprot

Glutamate ionotropic receptor kainate type subunit 3
type: ProteinReference
xref: PTHR18966:SF174
xref: uniprot F1PWT6 552
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P26308 448
organism: Drosophila melanogaster

Glutamate receptor 4
type: ProteinReference
xref: PTHR18966:SF100
xref: uniprot Q9Z2W8 607
organism: Mus musculus

Glutamate receptor 3
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot Q9Z2W9 608
organism: Mus musculus

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot F6Q9S4 24
organism: Bos taurus

uniprot F6S5B1 554
type: UnificationXref
id: F6S5B1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CXD0 410
organism: Monodelphis domestica

Glutamate metabotropic receptor 6
type: ProteinReference
xref: uniprot F1N213 348
xref: PTHR24060:SF24
organism: Bos taurus

Solute carrier family 17 member 7
type: ProteinReference
xref: PTHR11662:SF29
xref: uniprot F6Y4M4 163
organism: Canis lupus familiaris

Protein kinase cAMP-activated catalytic subunit alpha
type: ProteinReference
xref: uniprot H2QFK0 35
xref: PTHR24353:SF82
organism: Pan troglodytes

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F6VM87 260
xref: PTHR19305:SF5
organism: Monodelphis domestica

uniprot Q8MM62 102
type: UnificationXref
id: Q8MM62
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 94

Glutamate ionotropic receptor kainate type subunit 3
type: ProteinReference
xref: uniprot A0A3Q1M9Y0 534
xref: PTHR18966:SF174
organism: Bos taurus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 391
organism: Bos taurus

uniprot A0A3Q1MR13 112
type: UnificationXref
id: A0A3Q1MR13
db: uniprot

uniprot A0A1D5PIW7 522
type: UnificationXref
id: A0A1D5PIW7
db: uniprot

Synaptosomal-associated protein 23
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot O09044 279
organism: Mus musculus

uniprot Q6PBY0 497
type: UnificationXref
id: Q6PBY0
db: uniprot

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa4 644
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7BB02 407
organism: Macaca mulatta

uniprot A0A1L1RKZ9 250
type: UnificationXref
id: A0A1L1RKZ9
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A8X8S6 253
xref: PTHR19305:SF14
organism: Caenorhabditis briggsae

Glutamate receptor ionotropic, kainate 1
type: ProteinReference
xref: PTHR18966:SF36
xref: uniprot P39086 583
organism: Homo sapiens

uniprot P43005 140
type: UnificationXref
id: P43005
db: uniprot

uniprot Q9WUF4 333
type: UnificationXref
id: Q9WUF4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF157
xref: uniprot A0A1D5PIW7 522
organism: Gallus gallus

Glutamate receptor ionotropic, kainate 2
type: ProteinReference
xref: PTHR18966:SF38
xref: uniprot P39087 584
organism: Mus musculus

uniprot Q62645 213
type: UnificationXref
id: Q62645
db: uniprot

uniprot A0A2I3TTD0 111
type: UnificationXref
id: A0A2I3TTD0
db: uniprot

uniprot P61266 295
type: UnificationXref
id: P61266
db: uniprot

uniprot P50151 456
type: UnificationXref
id: P50151
db: uniprot

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa21 654
cellular location: Glia c8
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P60879 291
type: UnificationXref
id: P60879
db: uniprot

uniprot P31324 75
type: UnificationXref
id: P31324
db: uniprot

Glutamate
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A8WZ27 113
type: UnificationXref
id: A8WZ27
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot O60262 436
organism: Homo sapiens

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot Q3ZCA7 485
organism: Bos taurus

uniprot E2RJB3 387
type: UnificationXref
id: E2RJB3
db: uniprot

uniprot F1MG21 547
type: UnificationXref
id: F1MG21
db: uniprot

PTHR19305:SF5
type: RelationshipXref
id: PTHR19305:SF5
db: PANTHER Family
relationship type: By Homology

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r62
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 685
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 686
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

PARTICIPANT STOICHIOMETRY r67 670
type: Stoichiometry
physical entity: Vglut
stoichiometric coefficient: 1.0

PTHR19305:SF9
type: RelationshipXref
id: PTHR19305:SF9
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r67 671
type: Stoichiometry
physical entity: Complex (Vglut/Glutamate)
stoichiometric coefficient: 1.0

uniprot M9PE71 276
type: UnificationXref
id: M9PE71
db: uniprot

uniprot F6WXK4 354
type: UnificationXref
id: F6WXK4
db: uniprot

Voltage-dependent calcium channel type A subunit alpha-1
type: ProteinReference
xref: PTHR45628:SF7
xref: uniprot P91645 237
organism: Drosophila melanogaster

uniprot H2Q3W7 427
type: UnificationXref
id: H2Q3W7
db: uniprot

uniprot P63027 300
type: UnificationXref
id: P63027
db: uniprot

PTHR19305:SF4
type: RelationshipXref
id: PTHR19305:SF4
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF162
type: RelationshipXref
id: PTHR11635:SF162
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

eco ECO:0000250 7
type: UnificationXref
id: ECO:0000250
db: eco

Glutamate receptor ionotropic, NMDA 3B
type: ProteinReference
evidence: Evidence 173
evidence: Evidence 168
xref: uniprot Q91ZU9 219
xref: PTHR18966:SF364
organism: Mus musculus

PTHR18966:SF99
type: RelationshipXref
id: PTHR18966:SF99
db: PANTHER Family
relationship type: By Homology

uniprot Q10282 479
type: UnificationXref
id: Q10282
db: uniprot

uniprot P04897 437
type: UnificationXref
id: P04897
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7D9M6 335
xref: PTHR16305:SF28
organism: Macaca mulatta

uniprot Q28HP6 310
type: UnificationXref
id: Q28HP6
db: uniprot

uniprot Q17QQ3 308
type: UnificationXref
id: Q17QQ3
db: uniprot

Glutamate receptor, ionotropic, kainate 5
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot Q2HJD2 599
organism: Bos taurus

GNB4 protein
type: ProteinReference
xref: uniprot A5PKD6 371
organism: Bos taurus

uniprot Q7Q6D4 504
type: UnificationXref
id: Q7Q6D4
db: uniprot

PKA
type: Protein
entity reference: PKA
feature: ACTIVE 106
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Amino acid transporter
type: ProteinReference
xref: uniprot Q7QI86 151
xref: PTHR11958:SF63
organism: Anopheles gambiae

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 55

uniprot Q12879 207
type: UnificationXref
id: Q12879
db: uniprot

PTHR11635:SF157
type: RelationshipXref
id: PTHR11635:SF157
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF156
type: RelationshipXref
id: PTHR11635:SF156
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FD32 417
organism: Macaca mulatta

PTHR11635:SF153
type: RelationshipXref
id: PTHR11635:SF153
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF152
type: RelationshipXref
id: PTHR11635:SF152
db: PANTHER Family
relationship type: By Homology

uniprot O35544 133
type: UnificationXref
id: O35544
db: uniprot

ncbitaxon 7739 378
type: UnificationXref
id: 7739
db: ncbitaxon

EAAT s15 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EAAT
stoichiometric coefficient: 1.0

PTHR11635:SF159
type: RelationshipXref
id: PTHR11635:SF159
db: PANTHER Family
relationship type: By Homology

uniprot G3X7Z2 234
type: UnificationXref
id: G3X7Z2
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha isoform 1
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H9EQQ4 42
organism: Macaca mulatta

Amino acid transporter
type: ProteinReference
xref: uniprot A0A2I3T0G3 110
xref: PTHR11958:SF24
organism: Pan troglodytes

Voltage-dependent N-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot G3X7Z2 234
xref: PTHR10037:SF289
organism: Bos taurus

PKA
type: ProteinReference
xref: P01035
standard name: Protein kinase A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Protein Kinase A Synonym: PKA Accession: P01035
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group III pathway.PROTEIN.GENERIC.PKA
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha
member entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit
member entity reference: PRKAR2A isoform 1
member entity reference: cAMP-dependent protein kinase catalytic subunit PRKX
member entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit
member entity reference: AGAP001384-PA
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
member entity reference: AGAP008039-PA (Fragment)
member entity reference: Protein kinase A catalytic subunit isoform 1
member entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit beta
member entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit
member entity reference: Uncharacterized protein
member entity reference: PRKACB isoform 3
member entity reference: cAMP-dependent protein kinase catalytic subunit 1
member entity reference: Protein kinase cAMP-dependent type I regulatory subunit alpha
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit beta
member entity reference: Prkar1a protein
member entity reference: cAMP-dependent protein kinase regulatory subunit
member entity reference: Protein kinase, cAMP-dependent, regulatory, type I, beta
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta
member entity reference: cAMP-dependent protein kinase type I regulatory subunit
member entity reference: Protein kinase, cAMP-dependent, regulatory, type II, alpha, B
member entity reference: cAMP-dependent protein kinase catalytic subunit gamma
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit alpha
member entity reference: cAMP-dependent protein kinase catalytic subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit 3
member entity reference: Protein kinase cAMP-activated catalytic subunit beta
member entity reference: Protein kinase A catalytic subunit
member entity reference: CAP family transcription factor
member entity reference: Protein kinase cAMP-activated catalytic subunit alpha
member entity reference: cAMP-dependent protein kinase type II regulatory subunit
member entity reference: Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta a
member entity reference: cGMP-dependent 3',5'-cGMP phosphodiesterase A
member entity reference: AGAP004940-PA
member entity reference: cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B
member entity reference: Protein kinase, X-linked
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
member entity reference: PRKACG isoform 1
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha isoform 1
member entity reference: Protein kinase A catalytic subunit isoform 2
member entity reference: PRKAR1A isoform 12
member entity reference: cAMP-dependent protein kinase catalytic subunit beta isoform 1

uniprot P35436 195
type: UnificationXref
id: P35436
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P22694 70
xref: PTHR24353:SF116
organism: Homo sapiens

uniprot F6TFY2 399
type: UnificationXref
id: F6TFY2
db: uniprot

uniprot H2QNS5 430
type: UnificationXref
id: H2QNS5
db: uniprot

PARTICIPANT STOICHIOMETRY r63 681
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r63 682
type: Stoichiometry
physical entity: Complex (SNARE Complex/Ca2+)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r72 694
type: Stoichiometry
physical entity: Complex (NMDA/Glutamate)
stoichiometric coefficient: 1.0

Glutamate [NMDA] receptor subunit zeta-1 isoform NR1-3
type: ProteinReference
evidence: Evidence 168
xref: uniprot F7GR67 186
xref: PTHR18966:SF377
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r72 692
type: Stoichiometry
physical entity: NMDA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r72 693
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r63 680
type: Stoichiometry
physical entity: SNARE Complex
stoichiometric coefficient: 1.0

PRKAR2A isoform 1
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot K7AEL3 43
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot R4GKD1 517
organism: Gallus gallus

uniprot F7ANC6 564
type: UnificationXref
id: F7ANC6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 414
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NLV4 392
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r31 684
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

uniprot F7G3J2 419
type: UnificationXref
id: F7G3J2
db: uniprot

PARTICIPANT STOICHIOMETRY r31 683
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot P31109 286
organism: Saccharomyces cerevisiae

uniprot Q6DGZ5 493
type: UnificationXref
id: Q6DGZ5
db: uniprot

GRIA1 isoform 11
type: ProteinReference
xref: uniprot A0A2I3TR48 531
xref: PTHR18966:SF157
organism: Pan troglodytes

uniprot P42260 585
type: UnificationXref
id: P42260
db: uniprot

uniprot P12370 60
type: UnificationXref
id: P12370
db: uniprot

uniprot Q3SZ98 484
type: UnificationXref
id: Q3SZ98
db: uniprot

PARTICIPANT STOICHIOMETRY r57 709
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r57 708
type: Stoichiometry
physical entity: Complex (GTP/G-Protein)
stoichiometric coefficient: 1.0

PTHR10218:SF73
type: RelationshipXref
id: PTHR10218:SF73
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r57 707
type: Stoichiometry
physical entity: Complex (mGluR4/6/ 7/8/ Glutamate)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r57 706
type: Stoichiometry
physical entity: Complex (mGluR4/6/ 7/8/ Glutamate/G-Protein/ GDP)
stoichiometric coefficient: 1.0

uniprot P32851 287
type: UnificationXref
id: P32851
db: uniprot

PARTICIPANT STOICHIOMETRY r57 705
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot P23763 285
type: UnificationXref
id: P23763
db: uniprot

uniprot P97445 238
type: UnificationXref
id: P97445
db: uniprot

uniprot P18851 446
type: UnificationXref
id: P18851
db: uniprot

uniprot P23819 581
type: UnificationXref
id: P23819
db: uniprot

Metabotropic glutamate receptor 6
type: ProteinReference
xref: uniprot P35349 358
xref: PTHR24060:SF24
organism: Rattus norvegicus

uniprot F7ERP8 413
type: UnificationXref
id: F7ERP8
db: uniprot

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa6 648
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 189518 99
type: UnificationXref
id: 189518
db: ncbitaxon

G protein subunit alpha i3
type: ProteinReference
xref: uniprot Q5I080 487
xref: PTHR10218:SF230
organism: Xenopus tropicalis

uniprot F7GR67 186
type: UnificationXref
id: F7GR67
db: uniprot

uniprot A0A2I3TR48 531
type: UnificationXref
id: A0A2I3TR48
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F2Z3T8 394
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot Q7Q6E0 505
type: UnificationXref
id: Q7Q6E0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7B4C1 565
xref: PTHR18966:SF157
organism: Monodelphis domestica

PTHR11635:SF129
type: RelationshipXref
id: PTHR11635:SF129
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF126
type: RelationshipXref
id: PTHR11635:SF126
db: PANTHER Family
relationship type: By Homology

uniprot C3ZSF0 377
type: UnificationXref
id: C3ZSF0
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 520
xref: PTHR18966:SF99
xref: uniprot F7HEB8 571
organism: Macaca mulatta

uniprot F1PXS6 180
type: UnificationXref
id: F1PXS6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24060:SF23
xref: uniprot F6R6X5 351
organism: Monodelphis domestica

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 18

uniprot Q9SDQ4 606
type: UnificationXref
id: Q9SDQ4
db: uniprot

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_r31
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 683
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 684
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

uniprot A2CG69 536
type: UnificationXref
id: A2CG69
db: uniprot

mGluR4/6/7/8
type: Protein
entity reference: mGluR4/6/7/8
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 630
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 508
organism: Mus musculus

uniprot F1PWT6 552
type: UnificationXref
id: F1PWT6
db: uniprot

eco ECO:0000305 18
type: UnificationXref
id: ECO:0000305
db: eco

uniprot A0A2I3RPT6 109
type: UnificationXref
id: A0A2I3RPT6
db: uniprot

uniprot P97772 224
type: UnificationXref
id: P97772
db: uniprot

ncbitaxon 5664 17
type: UnificationXref
id: 5664
db: ncbitaxon

uniprot H2PZA6 424
type: UnificationXref
id: H2PZA6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q90Z40 511
organism: Danio rerio

uniprot F6VUT7 261
type: UnificationXref
id: F6VUT7
db: uniprot

uniprot F1PJE5 393
type: UnificationXref
id: F1PJE5
db: uniprot

uniprot F7EBE7 412
type: UnificationXref
id: F7EBE7
db: uniprot

PARTICIPANT STOICHIOMETRY r67 669
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 406
organism: Macaca mulatta

uniprot A0A1D5QIS2 248
type: UnificationXref
id: A0A1D5QIS2
db: uniprot

uniprot F1MUT8 118
type: UnificationXref
id: F1MUT8
db: uniprot

uniprot P54311 460
type: UnificationXref
id: P54311
db: uniprot

t-SNARE protein aex-4
type: ProteinReference
xref: uniprot G5EEN8 270
organism: Caenorhabditis elegans

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: PTHR11824:SF17
xref: uniprot Q02641 241
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__mGluR_1_5-_Glutamate-RIGHT__Complex__mGluR_1_5__Glutamate_-_r71
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 697
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 696
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 695
left: mGluR 1/5
left: Glutamate
interaction type: HETERODIMER_ASSOCIATION
right: Complex (mGluR 1/5/ Glutamate)

Protein kinase A catalytic subunit isoform 2
type: ProteinReference
xref: uniprot E9AFM1 16
xref: PTHR24353:SF67
organism: Leishmania major

uniprot H2QXB9 37
type: UnificationXref
id: H2QXB9
db: uniprot

uniprot P61265 294
type: UnificationXref
id: P61265
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot P23763 285
organism: Homo sapiens

G protein subunit beta 3
type: ProteinReference
xref: uniprot H2R3A6 431
organism: Pan troglodytes

Excitatory amino acid transporter 1
type: ProteinReference
xref: uniprot P56564 146
xref: PTHR11958:SF24
organism: Mus musculus

uniprot A8XT20 538
type: UnificationXref
id: A8XT20
db: uniprot

uniprot F1N1E0 231
type: UnificationXref
id: F1N1E0
db: uniprot

GRM7 isoform 3
type: ProteinReference
xref: uniprot A0A2J8M0L8 342
xref: PTHR24060:SF98
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r59
controller: cAMP

uniprot Q6ZM67 215
type: UnificationXref
id: Q6ZM67
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G4Q0 32
xref: PTHR24353:SF82
organism: Monodelphis domestica

uniprot A0A2J8M0L8 342
type: UnificationXref
id: A0A2J8M0L8
db: uniprot

uniprot Q61626 602
type: UnificationXref
id: Q61626
db: uniprot

uniprot P18489 284
type: UnificationXref
id: P18489
db: uniprot

uniprot P22612 69
type: UnificationXref
id: P22612
db: uniprot

uniprot P63025 298
type: UnificationXref
id: P63025
db: uniprot

uniprot F1PE26 551
type: UnificationXref
id: F1PE26
db: uniprot

uniprot P00514 44
type: UnificationXref
id: P00514
db: uniprot

uniprot P42264 589
type: UnificationXref
id: P42264
db: uniprot

uniprot Q02641 241
type: UnificationXref
id: Q02641
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 17

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 4

uniprot F6VUY3 353
type: UnificationXref
id: F6VUY3
db: uniprot

ncbitaxon 44689 51
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot H2Q995 271
type: UnificationXref
id: H2Q995
db: uniprot

uniprot F6SR09 156
type: UnificationXref
id: F6SR09
db: uniprot

uniprot F6UJF5 352
type: UnificationXref
id: F6UJF5
db: uniprot

uniprot Q62442 317
type: UnificationXref
id: Q62442
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ERP8 413
organism: Ornithorhynchus anatinus

uniprot Q27687 86
type: UnificationXref
id: Q27687
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P36408 452
organism: Dictyostelium discoideum

Glutamate ionotropic receptor kainate type subunit 3
type: ProteinReference
xref: uniprot F7ANC6 564
xref: PTHR18966:SF174
organism: Ornithorhynchus anatinus

HETERODIMER_ASSOCIATION_LEFT__A_K-_Glutamate-RIGHT__Complex__A_K__Glutamate_-_r73
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 691
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 690
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 689
left: A/K
left: Glutamate
interaction type: HETERODIMER_ASSOCIATION
right: Complex (A/K/ Glutamate)

uniprot F7EP58 268
type: UnificationXref
id: F7EP58
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta isoform 1
type: ProteinReference
xref: uniprot F7EBQ5 31
xref: PTHR24353:SF116
organism: Macaca mulatta

uniprot Q01097 203
type: UnificationXref
id: Q01097
db: uniprot

uniprot F6YBQ8 559
type: UnificationXref
id: F6YBQ8
db: uniprot

Metabotropic glutamate receptor 8
type: ProteinReference
xref: PTHR24060:SF26
xref: uniprot P70579 360
organism: Rattus norvegicus

uniprot A0A2J8LE31 532
type: UnificationXref
id: A0A2J8LE31
db: uniprot

uniprot F1MYW8 391
type: UnificationXref
id: F1MYW8
db: uniprot

PTHR11958:SF24
type: RelationshipXref
id: PTHR11958:SF24
db: PANTHER Family
relationship type: By Homology

Neuronal synaptobrevin, isoform J
type: ProteinReference
xref: PTHR45701:SF3
xref: uniprot M9PE71 276
organism: Drosophila melanogaster

PTHR11958:SF22
type: RelationshipXref
id: PTHR11958:SF22
db: PANTHER Family
relationship type: By Homology

Evidence 594
type: Evidence
evidence code: IC
comment: Website http://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891

uniprot A0A1D5QE40 167
type: UnificationXref
id: A0A1D5QE40
db: uniprot

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: PTHR45628:SF6
xref: uniprot Q02294 240
organism: Rattus norvegicus

uniprot R4GKD1 517
type: UnificationXref
id: R4GKD1
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q5ZJ03 489
organism: Gallus gallus

uniprot Q9Z2P6 334
type: UnificationXref
id: Q9Z2P6
db: uniprot

GO GO:0008021 2
type: UnificationXref
id: GO:0008021
db: GO

Vesicular glutamate transporter 1
type: ProteinReference
xref: PTHR11662:SF29
xref: uniprot Q9P2U7 166
organism: Homo sapiens

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF98
xref: uniprot A8WZ27 113
organism: Caenorhabditis briggsae

Glutamate metabotropic receptor 1
type: ProteinReference
xref: PTHR24060:SF29
xref: uniprot H2QTV8 222
organism: Pan troglodytes

Amino acid transporter
type: ProteinReference
xref: uniprot F6ZDV3 126
xref: PTHR11958:SF93
organism: Macaca mulatta

Complex (Vglut/Glutamate)
type: Complex
component stoichiometry: Vglut s17 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glutamate s128 sa17 STOICHIOMETRY ID COMPLEX
component: Glutamate
component: Vglut
feature: COMPLEX BINDING FEATURE s112 a117 627
feature: COMPLEX BINDING FEATURE s112 a117 625
cellular location: synaptic vesicle

uniprot P31424 158
type: UnificationXref
id: P31424
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot F6XYX9 263
organism: Monodelphis domestica

PRKACB isoform 3
type: ProteinReference
xref: uniprot H2R1G3 38
xref: PTHR24353:SF116
organism: Pan troglodytes

Putative sodium-dependent excitatory amino acid transporter glt-4
type: ProteinReference
xref: uniprot Q22682 148
xref: PTHR11958:SF98
organism: Caenorhabditis elegans

uniprot P62872 463
type: UnificationXref
id: P62872
db: uniprot

uniprot K7E376 433
type: UnificationXref
id: K7E376
db: uniprot

uniprot F1NKF1 548
type: UnificationXref
id: F1NKF1
db: uniprot

uniprot F6T423 555
type: UnificationXref
id: F6T423
db: uniprot

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF24
xref: uniprot F7FKB2 128
organism: Monodelphis domestica

Glutamate s26 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

uniprot Q61016 491
type: UnificationXref
id: Q61016
db: uniprot

uniprot P51907 145
type: UnificationXref
id: P51907
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P17612 66
xref: PTHR24353:SF82
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 466
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 465
organism: Mus musculus

EAAT s21 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EAAT
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 463
organism: Canis lupus familiaris

N-methyl D-aspartate receptor subtype 2B
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 171
xref: PTHR18966:SF382
xref: uniprot F6T8S6 182
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 464
organism: Homo sapiens

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot P62881 468
organism: Mus musculus

uniprot A4IGZ2 370
type: UnificationXref
id: A4IGZ2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 467
organism: Mus musculus

Protein kinase cAMP-activated catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot F6T0T9 28
organism: Xenopus tropicalis

mGluR 1 5 s29 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR 1/5
stoichiometric coefficient: 1.0

uniprot H2Q0J3 336
type: UnificationXref
id: H2Q0J3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24060:SF23
xref: uniprot G7MRR5 355
organism: Macaca mulatta

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot F6UFJ7 259
organism: Macaca mulatta

uniprot Q10901 147
type: UnificationXref
id: Q10901
db: uniprot

uniprot Q6PH57 498
type: UnificationXref
id: Q6PH57
db: uniprot

NMDA
type: Protein
entity reference: NMDA
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa24 622
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q7PPI8 93
type: UnificationXref
id: Q7PPI8
db: uniprot

PTHR16305:SF28
type: RelationshipXref
id: PTHR16305:SF28
db: PANTHER Family
relationship type: By Homology

Glutamate receptor ionotropic, kainate 1
type: ProteinReference
xref: uniprot P22756 579
xref: PTHR18966:SF36
organism: Rattus norvegicus

uniprot P43006 141
type: UnificationXref
id: P43006
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 462
organism: Bos taurus

Ca2+
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=ION

uniprot Q5NCH9 363
type: UnificationXref
id: Q5NCH9
db: uniprot

uniprot P50153 457
type: UnificationXref
id: P50153
db: uniprot

PTHR11958:SF63
type: RelationshipXref
id: PTHR11958:SF63
db: PANTHER Family
relationship type: By Homology

uniprot P47743 359
type: UnificationXref
id: P47743
db: uniprot

AGAP009322-PA
type: ProteinReference
xref: uniprot Q7QGG0 320
xref: PTHR21230:SF62
organism: Anopheles gambiae

ACTIVE 106
type: EntityFeature
comment: Active state

Amino acid transporter (Fragment)
type: ProteinReference
xref: uniprot Q5TXC3 149
xref: PTHR11958:SF63
organism: Anopheles gambiae

Guanine nucleotide binding protein, beta 3
type: ProteinReference
xref: uniprot Q5XGD8 488
organism: Xenopus tropicalis

PTHR11958:SF67
type: RelationshipXref
id: PTHR11958:SF67
db: PANTHER Family
relationship type: By Homology

uniprot P63217 475
type: UnificationXref
id: P63217
db: uniprot

EAAT
type: Protein
entity reference: EAAT
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa18 660
cellular location: Glia c8
comment: SPECIES_TYPE=PROTEIN

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 36

Metabotropic glutamate receptor 1 isoform beta
type: ProteinReference
xref: uniprot F7GU00 221
xref: PTHR24060:SF29
organism: Macaca mulatta

A K s25 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: A/K
stoichiometric coefficient: 1.0

Excitatory amino acid transporter 4
type: ProteinReference
xref: PTHR11958:SF67
xref: uniprot O35921 134
organism: Rattus norvegicus

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s128 sa17 628
cellular location: synaptic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F6TDQ6 556
type: UnificationXref
id: F6TDQ6
db: uniprot

uniprot Q63666 318
type: UnificationXref
id: Q63666
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P68182 81
xref: PTHR24353:SF116
organism: Rattus norvegicus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P68181 80
organism: Mus musculus

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63044 301
xref: PTHR45701:SF5
organism: Mus musculus

uniprot F6PLI7 350
type: UnificationXref
id: F6PLI7
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63045 302
organism: Rattus norvegicus

uniprot F1NLV4 392
type: UnificationXref
id: F1NLV4
db: uniprot

Glutamate receptor 1
type: ProteinReference
xref: uniprot P23818 580
xref: PTHR18966:SF157
organism: Mus musculus

G Protein s5 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

uniprot Q9DBC7 104
type: UnificationXref
id: Q9DBC7
db: uniprot

Syntaxin 1A
type: ProteinReference
xref: uniprot Q0VFR6 305
xref: PTHR19957:SF84
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZSF0 377
organism: Branchiostoma floridae

Metabotropic glutamate receptor 1
type: ProteinReference
xref: uniprot P23385 223
xref: PTHR24060:SF29
organism: Rattus norvegicus

uniprot A0A1D5RJF9 524
type: UnificationXref
id: A0A1D5RJF9
db: uniprot

ncbitaxon 559292 53
type: UnificationXref
id: 559292
db: ncbitaxon

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot Q6TNT8 500
organism: Danio rerio

Glutamate receptor 2
type: ProteinReference
evidence: Evidence 520
xref: PTHR18966:SF99
xref: uniprot P23819 581
organism: Mus musculus

PTHR11958:SF89
type: RelationshipXref
id: PTHR11958:SF89
db: PANTHER Family
relationship type: By Homology

uniprot Q5TXC3 149
type: UnificationXref
id: Q5TXC3
db: uniprot

Excitatory amino acid transporter 3
type: ProteinReference
xref: uniprot P51907 145
xref: PTHR11958:SF97
organism: Rattus norvegicus

Excitatory amino acid transporter 3
type: ProteinReference
xref: PTHR11958:SF97
xref: uniprot P51906 144
organism: Mus musculus

Protein kinase A catalytic subunit
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q27687 86
organism: Leishmania major

uniprot P08753 440
type: UnificationXref
id: P08753
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63027 300
organism: Homo sapiens

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63026 299
organism: Bos taurus

uniprot E1BK87 175
type: UnificationXref
id: E1BK87
db: uniprot

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: uniprot P97445 238
xref: PTHR45628:SF3
organism: Mus musculus

Metabotropic glutamate receptor group III pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r61
pathway component: HETERODIMER_ASSOCIATION_LEFT__NMDA-_Glutamate-RIGHT__Complex__NMDA_Glutamate_-_r72
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r59
pathway component: DISSOCIATION_LEFT__GTP-_Complex__mGluR4_6__7_8__Glutamate_G_Protein__GDP_-RIGHT__Complex__mGluR4_6__7_8__Glutamate_-_Complex__GTP_G_Protein_-_GDP-_r57
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_r31
pathway component: DISSOCIATION_LEFT__Complex__Vglut_Glutamate_-RIGHT__Glutamate-_Vglut-_r68
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r62
pathway component: HETERODIMER_ASSOCIATION_LEFT__mGluR_5-_Glutamate-RIGHT__Complex__mGluR_5_Glutamate_-_r70
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__mGluR4_6__7_8__G_Protein_GDP_-_Glutamate-RIGHT__Complex__mGluR4_6__7_8__Glutamate_G_Protein__GDP_-_r56
pathway component: TRANSPORT_LEFT__Glutamate-RIGHT__Glutamate-_r64
pathway component: HETERODIMER_ASSOCIATION_LEFT__mGluR_1_5-_Glutamate-RIGHT__Complex__mGluR_1_5__Glutamate_-_r71
pathway component: HETERODIMER_ASSOCIATION_LEFT__Glutamate-_Vglut-RIGHT__Complex__Vglut_Glutamate_-_r67
pathway component: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_r58
pathway component: DISSOCIATION_LEFT__Complex__EAAT_Glutamate_-RIGHT__Glutamate-_EAAT-_r66
pathway component: HETERODIMER_ASSOCIATION_LEFT__Glutamate-_EAAT-RIGHT__Complex__EAAT_Glutamate_-_r69
pathway component: HETERODIMER_ASSOCIATION_LEFT__A_K-_Glutamate-RIGHT__Complex__A_K__Glutamate_-_r73
pathway component: HETERODIMER_ASSOCIATION_LEFT__EAAT-_Glutamate-RIGHT__Complex__EAAT_Glutamate_-_r65
pathway component: HETERODIMER_ASSOCIATION_LEFT__SNARE_Complex-_Ca2_PLUS_-RIGHT__Complex__SNARE_Complex_Ca2_PLUS__-_r63
xref: PANTHER Pathway P00039 1
comment: MODEL_NOTES=Panther Pathway: P00039 Group III Metabotropic Glutamate Receptors are composed of receptor proteins, mGlu4, mGlu6, mGlu7 and mGlu8, which are negatively coupled to PKA and intracellular cAMP signalling. These receptors are found in forebrain, retina, and cerebellum. Group III mGlu receptors have not been linked with as many neurological conditions as groups I and II, however they do appear to function as strong anticonvulsants in several experimental models of epilepsy. They also seem to be neuroprotective agents in models of ischemia. Website=http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10514855 Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12575822 PMID: 10514855 PMID: 12575822

Amino acid transporter
type: ProteinReference
xref: uniprot F6PQH1 121
xref: PTHR11958:SF93
organism: Ornithorhynchus anatinus

uniprot P56564 146
type: UnificationXref
id: P56564
db: uniprot

ncbitaxon 9615 14
type: UnificationXref
id: 9615
db: ncbitaxon

Glutamate receptor ionotropic, kainate 4
type: ProteinReference
xref: uniprot Q16099 597
xref: PTHR18966:SF171
organism: Homo sapiens

Amino acid transporter
type: ProteinReference
xref: PTHR11958:SF22
xref: uniprot A0A2I3TTD0 111
organism: Pan troglodytes

uniprot F6SB23 123
type: UnificationXref
id: F6SB23
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: uniprot P63024 297
xref: PTHR45701:SF6
organism: Mus musculus

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63025 298
organism: Rattus norvegicus

mGluR 5
type: Protein
entity reference: mGluR 5
cellular location: Glia c8
comment: SPECIES_TYPE=PROTEIN

Evidence 520
type: Evidence
evidence code: ISS
comment: Website Theglutamineresiduehttp://www.genome.ad.jp/dbget-bin/www_bget?hsa:2891

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 396
organism: Ornithorhynchus anatinus

Glia c8
type: CellularLocationVocabulary
comment: Glia

uniprot F6Q503 22
type: UnificationXref
id: F6Q503
db: uniprot

uniprot P63214 472
type: UnificationXref
id: P63214
db: uniprot

uniprot Q08C49 85
type: UnificationXref
id: Q08C49
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R9G5 384
organism: Canis lupus familiaris

Glutamate [NMDA] receptor subunit 1
type: ProteinReference
evidence: Evidence 168
xref: PTHR18966:SF377
xref: uniprot Q24418 210
organism: Drosophila melanogaster

VAMP2 isoform 3
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot H2RCB8 275
organism: Pan troglodytes

Glutamate metabotropic receptor 7
type: ProteinReference
xref: uniprot E1BLE8 346
xref: PTHR24060:SF98
organism: Bos taurus

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot O14775 435
organism: Homo sapiens

uniprot E7F101 177
type: UnificationXref
id: E7F101
db: uniprot

uniprot Q8VHN2 218
type: UnificationXref
id: Q8VHN2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot F6RIM7 398
organism: Monodelphis domestica

PTHR18966:SF505
type: RelationshipXref
id: PTHR18966:SF505
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r61 688
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r61 687
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot P21137 67
organism: Caenorhabditis elegans

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 383
organism: Canis lupus familiaris

uniprot A0A2I3TUD1 367
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

uniprot H2QQC5 574
type: UnificationXref
id: H2QQC5
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R2S3 382
organism: Canis lupus familiaris

uniprot Q6NW93 92
type: UnificationXref
id: Q6NW93
db: uniprot

uniprot F1A421 389
type: UnificationXref
id: F1A421
db: uniprot

PTHR18966:SF100
type: RelationshipXref
id: PTHR18966:SF100
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r68 668
type: Stoichiometry
physical entity: Vglut
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r68 667
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

uniprot Q1MTI1 309
type: UnificationXref
id: Q1MTI1
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 23

uniprot P16520 444
type: UnificationXref
id: P16520
db: uniprot

PARTICIPANT STOICHIOMETRY r68 666
type: Stoichiometry
physical entity: Complex (Vglut/Glutamate)
stoichiometric coefficient: 1.0

Protein kinase, cAMP-dependent, catalytic, beta a
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot Q7T374 97
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YBQ8 559
xref: PTHR18966:SF174
organism: Macaca mulatta

PTHR11958:SF98
type: RelationshipXref
id: PTHR11958:SF98
db: PANTHER Family
relationship type: By Homology

uniprot H2PZK9 425
type: UnificationXref
id: H2PZK9
db: uniprot

PTHR11958:SF99
type: RelationshipXref
id: PTHR11958:SF99
db: PANTHER Family
relationship type: By Homology

PTHR11958:SF97
type: RelationshipXref
id: PTHR11958:SF97
db: PANTHER Family
relationship type: By Homology

uniprot F7FXA9 418
type: UnificationXref
id: F7FXA9
db: uniprot

PTHR11958:SF93
type: RelationshipXref
id: PTHR11958:SF93
db: PANTHER Family
relationship type: By Homology

Amino acid transporter
type: ProteinReference
xref: uniprot F1PUW7 119
xref: PTHR11958:SF97
organism: Canis lupus familiaris

Excitatory amino acid transporter 3
type: ProteinReference
xref: PTHR11958:SF97
xref: uniprot F7H624 129
organism: Macaca mulatta

uniprot H2RCB8 275
type: UnificationXref
id: H2RCB8
db: uniprot

ncbitaxon 8364 29
type: UnificationXref
id: 8364
db: ncbitaxon

Protein kinase cAMP-dependent type II regulatory subunit alpha
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot E2RRD1 15
organism: Canis lupus familiaris

uniprot Q8CXT1 98
type: UnificationXref
id: Q8CXT1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r61
controller: PKA

uniprot F1NWG3 155
type: UnificationXref
id: F1NWG3
db: uniprot

Protein kinase cAMP-dependent type I regulatory subunit alpha
type: ProteinReference
xref: uniprot F6R7N8 26
xref: PTHR11635:SF129
organism: Monodelphis domestica

uniprot A0A1D5R2U8 523
type: UnificationXref
id: A0A1D5R2U8
db: uniprot

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot Q9DC51 513
xref: PTHR10218:SF230
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot A8XW88 11
organism: Caenorhabditis briggsae

uniprot A0A3Q1NGS8 368
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

uniprot F7GI54 421
type: UnificationXref
id: F7GI54
db: uniprot

Adenylate cyclase type 10
type: ProteinReference
xref: uniprot H2Q0J3 336
xref: PTHR16305:SF28
organism: Pan troglodytes

Calcium voltage-gated channel auxiliary subunit beta 1
type: ProteinReference
xref: uniprot A0A2I3TBK2 227
xref: PTHR11824:SF17
organism: Pan troglodytes

Glutamate ionotropic receptor AMPA type subunit 2
type: ProteinReference
evidence: Evidence 520
xref: PTHR18966:SF99
xref: uniprot F7FY70 569
organism: Ornithorhynchus anatinus

Glutamate s22 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

uniprot F7BB02 407
type: UnificationXref
id: F7BB02
db: uniprot

uniprot Q9Z2W8 607
type: UnificationXref
id: Q9Z2W8
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__mGluR_5-_Glutamate-RIGHT__Complex__mGluR_5_Glutamate_-_r70
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 700
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 698
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 699
left: mGluR 5
left: Glutamate
interaction type: HETERODIMER_ASSOCIATION
right: Complex (mGluR 5/Glutamate)

uniprot P62873 464
type: UnificationXref
id: P62873
db: uniprot

uniprot P41594 159
type: UnificationXref
id: P41594
db: uniprot

uniprot Q7Q6D3 503
type: UnificationXref
id: Q7Q6D3
db: uniprot

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: uniprot P12849 62
xref: PTHR11635:SF126
organism: Mus musculus

uniprot F1Q0W8 120
type: UnificationXref
id: F1Q0W8
db: uniprot

NMDA
type: Protein
entity reference: NMDA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

G protein alpha subunit Gi isoform X2
type: ProteinReference
xref: PTHR10218:SF310
xref: uniprot Q8WSS1 509
organism: Ciona intestinalis

PTHR18966:SF151
type: RelationshipXref
id: PTHR18966:SF151
db: PANTHER Family
relationship type: By Homology

uniprot Q5IS46 600
type: UnificationXref
id: Q5IS46
db: uniprot

PTHR18966:SF157
type: RelationshipXref
id: PTHR18966:SF157
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YMH2 264
xref: PTHR45701:SF6
organism: Macaca mulatta

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: uniprot O00555 235
xref: PTHR45628:SF3
organism: Homo sapiens

STATE_TRANSITION
type: RelationshipTypeVocabulary

Uncharacterized protein
type: ProteinReference
xref: PTHR11824:SF17
xref: uniprot F7HBW2 233
organism: Macaca mulatta

uniprot F1MBY1 546
type: UnificationXref
id: F1MBY1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF334
xref: uniprot F7DNS6 267
organism: Macaca mulatta

uniprot P23818 580
type: UnificationXref
id: P23818
db: uniprot

uniprot Q9ERB0 324
type: UnificationXref
id: Q9ERB0
db: uniprot

GTP
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P81900 82
type: UnificationXref
id: P81900
db: uniprot

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot F6WM87 30
xref: PTHR11635:SF129
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot F7A943 266
organism: Monodelphis domestica

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa25 624
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9P2U7 166
type: UnificationXref
id: Q9P2U7
db: uniprot

uniprot A0A1D5QYR9 249
type: UnificationXref
id: A0A1D5QYR9
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot H2Q9G5 428
organism: Pan troglodytes

uniprot Q9HAV0 514
type: UnificationXref
id: Q9HAV0
db: uniprot

PTHR18966:SF527
type: RelationshipXref
id: PTHR18966:SF527
db: PANTHER Family
relationship type: By Homology

uniprot Q02294 240
type: UnificationXref
id: Q02294
db: uniprot

uniprot F6YMH2 264
type: UnificationXref
id: F6YMH2
db: uniprot

uniprot F7H6T7 422
type: UnificationXref
id: F7H6T7
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 12

uniprot Q5XGD8 488
type: UnificationXref
id: Q5XGD8
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 68

uniprot P23385 223
type: UnificationXref
id: P23385
db: uniprot

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot P29829 450
organism: Drosophila melanogaster

uniprot P19491 576
type: UnificationXref
id: P19491
db: uniprot

Syntaxin 1B
type: ProteinReference
xref: PTHR19957:SF334
xref: uniprot F7EP58 268
organism: Xenopus tropicalis

G protein subunit alpha i1
type: ProteinReference
xref: uniprot A0A2I3S4R3 366
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7F580 416
organism: Macaca mulatta

uniprot F6WM87 30
type: UnificationXref
id: F6WM87
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot Q9CXP8 512
organism: Mus musculus

uniprot Q24418 210
type: UnificationXref
id: Q24418
db: uniprot

uniprot O95721 283
type: UnificationXref
id: O95721
db: uniprot

Complex (mGluR 5/Glutamate)
type: Complex
component stoichiometry: mGluR 5 s126 sa20 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glutamate s24 sa21 STOICHIOMETRY ID COMPLEX
component: Glutamate
component: mGluR 5
feature: COMPLEX BINDING FEATURE s116 a123 651
feature: COMPLEX BINDING FEATURE s116 a123 653
cellular location: Glia c8

uniprot P62871 462
type: UnificationXref
id: P62871
db: uniprot

uniprot Q16478 598
type: UnificationXref
id: Q16478
db: uniprot

uniprot H2QMN4 429
type: UnificationXref
id: H2QMN4
db: uniprot

Glutamate receptor ionotropic, kainate 2
type: ProteinReference
xref: PTHR18966:SF38
xref: uniprot P42260 585
organism: Rattus norvegicus

Glutamate receptor, ionotropic, kainate 1b
type: ProteinReference
xref: uniprot A0A286YAY2 527
xref: PTHR18966:SF36
organism: Danio rerio

Glutamate receptor 3
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot P42263 588
organism: Homo sapiens

Metabotropic glutamate receptor 5
type: ProteinReference
xref: uniprot Q3UVX5 160
xref: PTHR24060:SF30
organism: Mus musculus

Glutamate receptor ionotropic, kainate 3
type: ProteinReference
xref: uniprot P42264 589
xref: PTHR18966:SF174
organism: Rattus norvegicus

Glutamate receptor 1
type: ProteinReference
xref: uniprot P42261 586
xref: PTHR18966:SF157
organism: Homo sapiens

Glutamate receptor 2
type: ProteinReference
evidence: Evidence 520
xref: PTHR18966:SF99
xref: uniprot P42262 587
organism: Homo sapiens

PTHR24353:SF133
type: RelationshipXref
id: PTHR24353:SF133
db: PANTHER Family
relationship type: By Homology

uniprot Q7Q6D2 502
type: UnificationXref
id: Q7Q6D2
db: uniprot

Glutamate ionotropic receptor kainate type subunit 2
type: ProteinReference
xref: PTHR18966:SF38
xref: uniprot F1MG21 547
organism: Bos taurus

uniprot O00222 356
type: UnificationXref
id: O00222
db: uniprot

PTHR24353:SF137
type: RelationshipXref
id: PTHR24353:SF137
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF135
type: RelationshipXref
id: PTHR24353:SF135
db: PANTHER Family
relationship type: By Homology

Glutamate receptor ionotropic, kainate 5
type: ProteinReference
xref: uniprot Q16478 598
xref: PTHR18966:SF351
organism: Homo sapiens

uniprot P20353 447
type: UnificationXref
id: P20353
db: uniprot

Glutamate ionotropic receptor AMPA type subunit 4
type: ProteinReference
xref: PTHR18966:SF100
xref: uniprot F6YN64 560
organism: Monodelphis domestica

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 378

STATE_TRANSITION_LEFT__AC-RIGHT__AC-_r58
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 704
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 703
left: AC
interaction type: STATE_TRANSITION
right: AC

HETERODIMER_ASSOCIATION_LEFT__Complex__mGluR4_6__7_8__G_Protein_GDP_-_Glutamate-RIGHT__Complex__mGluR4_6__7_8__Glutamate_G_Protein__GDP_-_r56
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 711
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 712
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 710
left: Complex (mGluR4/6/ 7/8/ G-Protein/GDP)
left: Glutamate
interaction type: HETERODIMER_ASSOCIATION
right: Complex (mGluR4/6/ 7/8/ Glutamate/G-Protein/ GDP)

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q1D9 426
organism: Pan troglodytes

uniprot F6XWE8 403
type: UnificationXref
id: F6XWE8
db: uniprot

Ca2+
type: Protein
entity reference: Ca2+
feature: ACTIVE 106
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot Q7PXM3 216
type: UnificationXref
id: Q7PXM3
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P52287 459
organism: Rattus norvegicus

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot F6UBJ8 258
organism: Xenopus tropicalis

uniprot P34299 582
type: UnificationXref
id: P34299
db: uniprot

uniprot P63078 470
type: UnificationXref
id: P63078
db: uniprot

Syntaxin-1A
type: ProteinReference
xref: uniprot P32851 287
xref: PTHR19957:SF84
organism: Rattus norvegicus

uniprot A4IFL6 369
type: UnificationXref
id: A4IFL6
db: uniprot

uniprot E2QUL2 254
type: UnificationXref
id: E2QUL2
db: uniprot

uniprot Q22682 148
type: UnificationXref
id: Q22682
db: uniprot

PTHR24353:SF128
type: RelationshipXref
id: PTHR24353:SF128
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r66 672
type: Stoichiometry
physical entity: Complex (EAAT/Glutamate)
stoichiometric coefficient: 1.0

uniprot F7EZT2 415
type: UnificationXref
id: F7EZT2
db: uniprot

PARTICIPANT STOICHIOMETRY r66 673
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r66 674
type: Stoichiometry
physical entity: EAAT
stoichiometric coefficient: 1.0

uniprot P48664 143
type: UnificationXref
id: P48664
db: uniprot

Glutamate receptor ionotropic, NMDA 2A
type: ProteinReference
evidence: Evidence 192
evidence: Evidence 193
evidence: Evidence 197
evidence: Evidence 196
xref: PTHR18966:SF407
xref: uniprot P35436 195
organism: Mus musculus

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 510

PTHR18966:SF174
type: RelationshipXref
id: PTHR18966:SF174
db: PANTHER Family
relationship type: By Homology

PTHR18966:SF171
type: RelationshipXref
id: PTHR18966:SF171
db: PANTHER Family
relationship type: By Homology

Synaptosomal-associated protein 23
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot O00161 277
organism: Homo sapiens

Guanylyl cyclase
type: ProteinReference
xref: PTHR43642:SF2
xref: uniprot Q551V8 337
organism: Dictyostelium discoideum

PTHR24353:SF117
type: RelationshipXref
id: PTHR24353:SF117
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF116
type: RelationshipXref
id: PTHR24353:SF116
db: PANTHER Family
relationship type: By Homology

uniprot F6RIM7 398
type: UnificationXref
id: F6RIM7
db: uniprot

uniprot P60880 292
type: UnificationXref
id: P60880
db: uniprot

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
type: ProteinReference
xref: uniprot A3KMS9 9
xref: PTHR24353:SF82
organism: Danio rerio

Excitatory amino acid transporter 4
type: ProteinReference
xref: PTHR11958:SF67
xref: uniprot O35544 133
organism: Mus musculus

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot B2RSH2 374
organism: Mus musculus

Vesicle associated membrane protein 1
type: ProteinReference
xref: uniprot F1PRG8 256
xref: PTHR45701:SF1
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(K) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot F6VL43 401
organism: Macaca mulatta

uniprot O15399 191
type: UnificationXref
id: O15399
db: uniprot

uniprot J9JH96 157
type: UnificationXref
id: J9JH96
db: uniprot

ATP
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Glutamate metabotropic receptor 8
type: ProteinReference
xref: uniprot F6UJF5 352
xref: PTHR24060:SF26
organism: Monodelphis domestica

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P05132 48
xref: PTHR24353:SF82
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P05131 47
xref: PTHR24353:SF116
organism: Bos taurus

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: PTHR11824:SF17
xref: uniprot Q8R3Z5 245
organism: Mus musculus

uniprot F7GU00 221
type: UnificationXref
id: F7GU00
db: uniprot

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 99

Syntaxin-1A
type: ProteinReference
xref: PTHR19957:SF84
xref: uniprot O35526 280
organism: Mus musculus

uniprot Q13003 596
type: UnificationXref
id: Q13003
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot Q10282 479
organism: Schizosaccharomyces pombe

uniprot P16905 64
type: UnificationXref
id: P16905
db: uniprot

uniprot E1B965 345
type: UnificationXref
id: E1B965
db: uniprot

uniprot F6V461 400
type: UnificationXref
id: F6V461
db: uniprot

VTI1A isoform 1
type: ProteinReference
xref: uniprot H2RC26 274
xref: PTHR21230:SF62
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RJB3 387
organism: Canis lupus familiaris

uniprot H2QUQ1 273
type: UnificationXref
id: H2QUQ1
db: uniprot

Amino acid transporter
type: ProteinReference
xref: uniprot F6T507 124
xref: PTHR11958:SF97
organism: Monodelphis domestica

uniprot F6VL43 401
type: UnificationXref
id: F6VL43
db: uniprot

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot E2RRA1 13
xref: PTHR11635:SF156
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit beta-5b
type: ProteinReference
xref: uniprot Q6PBY0 497
organism: Danio rerio

uniprot F6VTB5 183
type: UnificationXref
id: F6VTB5
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1PJE5 393
organism: Canis lupus familiaris

AC
type: ProteinReference
xref: P01043
standard name: adenylate cyclase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Adenylate Cyclase Synonym: AC Accession: P01043
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group III pathway.PROTEIN.GENERIC.AC
member entity reference: Adenylate/guanylate cyclase
member entity reference: Uncharacterized protein
member entity reference: Guanylyl cyclase
member entity reference: Adenylate cyclase type 10

uniprot Q9DC51 513
type: UnificationXref
id: Q9DC51
db: uniprot

uniprot F7E427 411
type: UnificationXref
id: F7E427
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF38
xref: uniprot F1NU20 549
organism: Gallus gallus

mGluR4 6 7 8 s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR4/6/7/8
stoichiometric coefficient: 1.0

uniprot O70404 281
type: UnificationXref
id: O70404
db: uniprot

uniprot Q3ZCA7 485
type: UnificationXref
id: Q3ZCA7
db: uniprot

PANTHER Pathway P00039 1
type: UnificationXref
id: P00039
db: PANTHER Pathway

uniprot P19493 578
type: UnificationXref
id: P19493
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot Q8MJ44 100
xref: PTHR24353:SF82
organism: Canis lupus familiaris

uniprot P63024 297
type: UnificationXref
id: P63024
db: uniprot

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P13861 63
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot E9GNI4 19
organism: Daphnia pulex

ncbitaxon 7165 94
type: UnificationXref
id: 7165
db: ncbitaxon

Amino acid transporter
type: ProteinReference
xref: uniprot F6SB23 123
xref: PTHR11958:SF93
organism: Monodelphis domestica

PTHR21230:SF62
type: RelationshipXref
id: PTHR21230:SF62
db: PANTHER Family
relationship type: By Homology

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 367
organism: Pan troglodytes

Glutamate receptor, ionotropic, AMPA 2a
type: ProteinReference
evidence: Evidence 520
xref: PTHR18966:SF99
xref: uniprot A0A0R4ING5 519
organism: Danio rerio

uniprot Q9N0Y0 327
type: UnificationXref
id: Q9N0Y0
db: uniprot

STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r61
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 688
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 687
left: Ca2+
interaction type: STATE_TRANSITION
right: Ca2+

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot Q9N0Y0 327
xref: PTHR45701:SF5
organism: Macaca mulatta

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q3T0Y8 312
xref: PTHR45701:SF7
organism: Bos taurus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P36975 288
xref: PTHR19305:SF14
organism: Drosophila melanogaster

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 405
organism: Monodelphis domestica

ncbitaxon 367110 84
type: UnificationXref
id: 367110
db: ncbitaxon

PTHR10037:SF290
type: RelationshipXref
id: PTHR10037:SF290
db: PANTHER Family
relationship type: By Homology

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q15836 306
organism: Homo sapiens

uniprot A0A2I3T3T7 529
type: UnificationXref
id: A0A2I3T3T7
db: uniprot

uniprot P31109 286
type: UnificationXref
id: P31109
db: uniprot

uniprot P29387 449
type: UnificationXref
id: P29387
db: uniprot

uniprot Q07652 242
type: UnificationXref
id: Q07652
db: uniprot

Complex (EAAT/Glutamate)
type: Complex
component stoichiometry: Glutamate s22 sa19 STOICHIOMETRY ID COMPLEX
component stoichiometry: EAAT s21 sa18 STOICHIOMETRY ID COMPLEX
component: Glutamate
component: EAAT
feature: COMPLEX BINDING FEATURE s114 a121 661
feature: COMPLEX BINDING FEATURE s114 a121 659
cellular location: Glia c8

uniprot O09044 279
type: UnificationXref
id: O09044
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot P63096 471
organism: Homo sapiens

Synaptosomal-associated protein 25-B
type: ProteinReference
xref: uniprot Q6PC54 319
xref: PTHR19305:SF5
organism: Danio rerio

Excitatory amino acid transporter 1
type: ProteinReference
xref: uniprot P24942 136
xref: PTHR11958:SF24
organism: Rattus norvegicus

uniprot Q93YT1 605
type: UnificationXref
id: Q93YT1
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6TFY2 399
organism: Macaca mulatta

uniprot Q8EZ52 339
type: UnificationXref
id: Q8EZ52
db: uniprot

Excitatory amino acid transporter 4
type: ProteinReference
xref: PTHR11958:SF67
xref: uniprot P48664 143
organism: Homo sapiens

uniprot E1JHQ6 117
type: UnificationXref
id: E1JHQ6
db: uniprot

uniprot P10824 442
type: UnificationXref
id: P10824
db: uniprot

uniprot P50150 455
type: UnificationXref
id: P50150
db: uniprot

PTHR10037:SF289
type: RelationshipXref
id: PTHR10037:SF289
db: PANTHER Family
relationship type: By Homology

Glutamate receptor, ionotropic, AMPA 3b
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot A0A286Y9Q6 525
organism: Danio rerio

uniprot Q62634 165
type: UnificationXref
id: Q62634
db: uniprot

Glutamate receptor ionotropic, NMDA 2C
type: ProteinReference
evidence: Evidence 192
evidence: Evidence 193
xref: uniprot Q14957 209
xref: PTHR18966:SF361
organism: Homo sapiens

uniprot F7HEB8 571
type: UnificationXref
id: F7HEB8
db: uniprot

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 20

uniprot F7ES96 414
type: UnificationXref
id: F7ES96
db: uniprot

uniprot F1PRG8 256
type: UnificationXref
id: F1PRG8
db: uniprot

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot Q9DBC7 104
xref: PTHR11635:SF129
organism: Mus musculus

Glutamate receptor ionotropic, kainate 2
type: ProteinReference
xref: PTHR18966:SF38
xref: uniprot Q13002 595
organism: Homo sapiens

Glutamate receptor ionotropic, kainate 3
type: ProteinReference
xref: uniprot Q13003 596
xref: PTHR18966:SF174
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63078 470
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 469
organism: Rattus norvegicus

uniprot Q9N280 154
type: UnificationXref
id: Q9N280
db: uniprot

uniprot Q8WSS1 509
type: UnificationXref
id: Q8WSS1
db: uniprot

LD03592p
type: ProteinReference
xref: uniprot Q9W1I8 332
xref: PTHR19305:SF9
organism: Drosophila melanogaster

uniprot A0A2J8N6N1 228
type: UnificationXref
id: A0A2J8N6N1
db: uniprot

mGluR 5 s126 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR 5
stoichiometric coefficient: 1.0

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 168
xref: PTHR18966:SF377
xref: uniprot P35438 198
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 461
organism: Rattus norvegicus

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 168
xref: PTHR18966:SF377
xref: uniprot P35439 199
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 460
organism: Rattus norvegicus

Putative SNAP25 homologous protein SNAP30
type: ProteinReference
xref: uniprot Q9LMG8 325
organism: Arabidopsis thaliana

uniprot F7HBW2 233
type: UnificationXref
id: F7HBW2
db: uniprot

uniprot O02495 278
type: UnificationXref
id: O02495
db: uniprot

GRIN2B isoform 3
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 171
xref: PTHR18966:SF382
xref: uniprot H2Q5I0 189
organism: Pan troglodytes

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 411
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
evidence: Evidence 520
xref: PTHR18966:SF99
xref: uniprot F6Y7R9 558
organism: Monodelphis domestica

uniprot A0A1D5Q6W9 108
type: UnificationXref
id: A0A1D5Q6W9
db: uniprot

uniprot Q7ZW82 506
type: UnificationXref
id: Q7ZW82
db: uniprot

uniprot P22756 579
type: UnificationXref
id: P22756
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 498
organism: Danio rerio

uniprot Q7QI86 151
type: UnificationXref
id: Q7QI86
db: uniprot

PKA
type: Protein
entity reference: PKA
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__EAAT-_Glutamate-RIGHT__Complex__EAAT_Glutamate_-_r65
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 676
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 675
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 677
left: Glutamate
left: EAAT
interaction type: HETERODIMER_ASSOCIATION
right: Complex (EAAT/Glutamate)

uniprot H2Q5I0 189
type: UnificationXref
id: H2Q5I0
db: uniprot

uniprot A3KMS9 9
type: UnificationXref
id: A3KMS9
db: uniprot

mGluR4 6 7 8 s9 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR4/6/7/8
stoichiometric coefficient: 1.0

Glutamate s28 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Complex (mGluR 1/5/ Glutamate)
type: Complex
component stoichiometry: Glutamate s30 sa27 STOICHIOMETRY ID COMPLEX
component stoichiometry: mGluR 1 5 s29 sa26 STOICHIOMETRY ID COMPLEX
component: Glutamate
component: mGluR 1/5
feature: COMPLEX BINDING FEATURE s124 a134 619
feature: COMPLEX BINDING FEATURE s124 a134 617
cellular location: cytosol

uniprot P51817 79
type: UnificationXref
id: P51817
db: uniprot

uniprot E2RDG9 347
type: UnificationXref
id: E2RDG9
db: uniprot

Excitatory amino acid transporter 3
type: ProteinReference
xref: uniprot Q95135 153
xref: PTHR11958:SF97
organism: Bos taurus

GRIA3 isoform 2
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot A0A2J8LE31 532
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6WXK4 354
xref: PTHR24060:SF98
organism: Macaca mulatta

GRIA2 isoform 6
type: ProteinReference
evidence: Evidence 520
xref: PTHR18966:SF99
xref: uniprot H2QQC5 574
organism: Pan troglodytes

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot H2Q995 271
xref: PTHR19305:SF4
organism: Pan troglodytes

Glutamate receptor ionotropic, NMDA 2D
type: ProteinReference
evidence: Evidence 192
evidence: Evidence 193
evidence: Evidence 194
xref: uniprot Q03391 205
xref: PTHR18966:SF385
organism: Mus musculus

Metabotropic glutamate receptor 6
type: ProteinReference
xref: uniprot O15303 357
xref: PTHR24060:SF24
organism: Homo sapiens

uniprot Q15KE4 480
type: UnificationXref
id: Q15KE4
db: uniprot

Guanine nucleotide-binding protein (G protein), beta 5
type: ProteinReference
xref: uniprot F7EBE7 412
organism: Xenopus tropicalis

uniprot A0A3Q1M9Y0 534
type: UnificationXref
id: A0A3Q1M9Y0
db: uniprot

A/K
type: Protein
entity reference: A/K
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6V461 400
organism: Ornithorhynchus anatinus

uniprot P60877 289
type: UnificationXref
id: P60877
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 314

mGluR4/6/7/8
type: Protein
entity reference: mGluR4/6/7/8
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa5 646
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6PBR4 496
organism: Danio rerio

Amino acid transporter
type: ProteinReference
xref: uniprot Q6P4V2 150
xref: PTHR11958:SF24
organism: Danio rerio

EAAT
type: ProteinReference
xref: P01036
standard name: Excitatory amino acid transporter
comment: ENTITY_REFERENCE_NOTES= Long Name: Excitatory amino acid transporter Synonym: EAAT1,GLAST1,GLT-1 Accession: P01036
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group III pathway.PROTEIN.GENERIC.EAAT
member entity reference: Excitatory amino acid transporter 2
member entity reference: Amino acid transporter
member entity reference: Excitatory amino acid transporter 1
member entity reference: Excitatory amino acid transporter 3
member entity reference: Excitatory amino acid transporter 4
member entity reference: Excitatory amino acid transporter 5
member entity reference: Amino acid transporter (Fragment)
member entity reference: Putative sodium-dependent excitatory amino acid transporter glt-4
member entity reference: Excitatory amino acid transporter

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot A0A2I3SR99 251
xref: PTHR45701:SF7
organism: Pan troglodytes

uniprot P52287 459
type: UnificationXref
id: P52287
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A0A1D5QYR9 249
xref: PTHR19305:SF4
organism: Macaca mulatta

uniprot E1C2Q1 542
type: UnificationXref
id: E1C2Q1
db: uniprot

uniprot Q6PBR4 496
type: UnificationXref
id: Q6PBR4
db: uniprot

uniprot Q5I080 487
type: UnificationXref
id: Q5I080
db: uniprot

uniprot Q92356 321
type: UnificationXref
id: Q92356
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2b
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot X1WDQ5 518
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR11662:SF29
xref: uniprot A0A1D5QET0 161
organism: Macaca mulatta

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot P29387 449
organism: Mus musculus

uniprot Q8C0T9 338
type: UnificationXref
id: Q8C0T9
db: uniprot

uniprot O35526 280
type: UnificationXref
id: O35526
db: uniprot

uniprot A5PEW5 252
type: UnificationXref
id: A5PEW5
db: uniprot

uniprot H2R3M7 39
type: UnificationXref
id: H2R3M7
db: uniprot

GDP
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 486
organism: Danio rerio

Amino acid transporter
type: ProteinReference
xref: uniprot F7CSQ4 127
xref: PTHR11958:SF24
organism: Xenopus tropicalis

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 53

uniprot G5EEN8 270
type: UnificationXref
id: G5EEN8
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 61

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 490
organism: Mus musculus

Glutamate receptor ionotropic, kainate 5
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot Q63273 603
organism: Rattus norvegicus

PTHR11824:SF17
type: RelationshipXref
id: PTHR11824:SF17
db: PANTHER Family
relationship type: By Homology

Glutamate receptor ionotropic, NMDA 2A
type: ProteinReference
evidence: Evidence 192
evidence: Evidence 193
evidence: Evidence 197
evidence: Evidence 196
xref: PTHR18966:SF407
xref: uniprot Q12879 207
organism: Homo sapiens

uniprot Q05586 206
type: UnificationXref
id: Q05586
db: uniprot

uniprot Q8BMF5 604
type: UnificationXref
id: Q8BMF5
db: uniprot

uniprot F6R7N8 26
type: UnificationXref
id: F6R7N8
db: uniprot

uniprot Q61290 244
type: UnificationXref
id: Q61290
db: uniprot

uniprot E2RRD1 15
type: UnificationXref
id: E2RRD1
db: uniprot

AGAP001506-PA
type: ProteinReference
xref: uniprot Q7PXP3 501
organism: Anopheles gambiae

uniprot P39086 583
type: UnificationXref
id: P39086
db: uniprot

uniprot Q3UVX5 160
type: UnificationXref
id: Q3UVX5
db: uniprot

uniprot P43425 453
type: UnificationXref
id: P43425
db: uniprot

uniprot Q5ASG1 313
type: UnificationXref
id: Q5ASG1
db: uniprot

uniprot Q6R6I2 214
type: UnificationXref
id: Q6R6I2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 491
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot Q61017 492
xref: PTHR13809:SF28
organism: Mus musculus

uniprot F6Q9S4 24
type: UnificationXref
id: F6Q9S4
db: uniprot

Protein CBR-NMR-1
type: ProteinReference
evidence: Evidence 168
xref: PTHR18966:SF377
xref: uniprot A8WUE7 174
organism: Caenorhabditis briggsae

Adenylate cyclase type 10
type: ProteinReference
xref: PTHR16305:SF28
xref: uniprot Q96PN6 340
organism: Homo sapiens

uniprot Q6TH03 499
type: UnificationXref
id: Q6TH03
db: uniprot

uniprot Q03445 592
type: UnificationXref
id: Q03445
db: uniprot

CAP family transcription factor
type: ProteinReference
xref: PTHR11635:SF157
xref: uniprot Q8CXT1 98
organism: Leptospira interrogans

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q9WUF4 333
xref: PTHR45701:SF7
organism: Rattus norvegicus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q5R1X1 315
xref: PTHR19305:SF5
organism: Pan troglodytes

Syntaxin 1B
type: ProteinReference
xref: PTHR19957:SF334
xref: uniprot Q1MTI1 309
organism: Danio rerio

uniprot F6XYX9 263
type: UnificationXref
id: F6XYX9
db: uniprot

synaptic vesicle
type: CellularLocationVocabulary
xref: GO GO:0008021 2

Uncharacterized protein
type: ProteinReference
evidence: Evidence 173
evidence: Evidence 168
xref: uniprot F6VTB5 183
xref: PTHR18966:SF397
organism: Macaca mulatta

uniprot P31323 74
type: UnificationXref
id: P31323
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 29

uniprot A4FV52 162
type: UnificationXref
id: A4FV52
db: uniprot

Glutamate receptor ionotropic, NMDA 3A
type: ProteinReference
evidence: Evidence 173
evidence: Evidence 168
xref: uniprot Q8TCU5 217
xref: PTHR18966:SF397
organism: Homo sapiens

TRIGGER
type: RelationshipTypeVocabulary

uniprot Q9W3J1 516
type: UnificationXref
id: Q9W3J1
db: uniprot

uniprot Q8R3Z5 245
type: UnificationXref
id: Q8R3Z5
db: uniprot

uniprot P36600 77
type: UnificationXref
id: P36600
db: uniprot

uniprot P16912 65
type: UnificationXref
id: P16912
db: uniprot

uniprot Q9BV40 323
type: UnificationXref
id: Q9BV40
db: uniprot

ncbitaxon 5786 390
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot F1P8E3 349
type: UnificationXref
id: F1P8E3
db: uniprot

uniprot F7CS79 185
type: UnificationXref
id: F7CS79
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P49177 454
organism: Arabidopsis thaliana

uniprot Q3TXX4 164
type: UnificationXref
id: Q3TXX4
db: uniprot

ncbitaxon 7719 510
type: UnificationXref
id: 7719
db: ncbitaxon

uniprot P35349 358
type: UnificationXref
id: P35349
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P30625 72
organism: Caenorhabditis elegans

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa9 636
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O35921 134
type: UnificationXref
id: O35921
db: uniprot

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s127 sa15 658
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7CFG8 408
type: UnificationXref
id: F7CFG8
db: uniprot

ncbitaxon 6239 68
type: UnificationXref
id: 6239
db: ncbitaxon

Complex (A/K/ Glutamate)
type: Complex
component stoichiometry: A K s25 sa22 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glutamate s26 sa23 STOICHIOMETRY ID COMPLEX
component: A/K
component: Glutamate
feature: COMPLEX BINDING FEATURE s120 a130 613
feature: COMPLEX BINDING FEATURE s120 a130 615
cellular location: cytosol

uniprot Q0VFC4 478
type: UnificationXref
id: Q0VFC4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R2U8 523
xref: PTHR18966:SF171
organism: Macaca mulatta

Voltage-dependent R-type calcium channel subunit alpha-1E
type: ProteinReference
xref: uniprot Q15878 243
xref: PTHR45628:SF5
organism: Homo sapiens

ncbitaxon 6669 20
type: UnificationXref
id: 6669
db: ncbitaxon

GO GO:0005829 4
type: UnificationXref
id: GO:0005829
db: GO

Protein kinase, cAMP-dependent, regulatory, type II, alpha, B
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot Q6NW93 92
organism: Danio rerio

uniprot O77062 135
type: UnificationXref
id: O77062
db: uniprot

PARTICIPANT STOICHIOMETRY r69 665
type: Stoichiometry
physical entity: Complex (EAAT/Glutamate)
stoichiometric coefficient: 1.0

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot E2QUL2 254
xref: PTHR45701:SF7
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r69 664
type: Stoichiometry
physical entity: EAAT
stoichiometric coefficient: 1.0

Glutamate ionotropic receptor NMDA type subunit 3A
type: ProteinReference
evidence: Evidence 173
evidence: Evidence 168
xref: uniprot E2QUL1 176
xref: PTHR18966:SF397
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r69 663
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

uniprot P27791 71
type: UnificationXref
id: P27791
db: uniprot

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot F5HH30 395
organism: Neurospora crassa

Glutamate ionotropic receptor kainate type subunit 1
type: ProteinReference
xref: PTHR18966:SF36
xref: uniprot A0A1D5PHB3 521
organism: Gallus gallus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IGZ2 370
organism: Xenopus tropicalis

uniprot P00515 45
type: UnificationXref
id: P00515
db: uniprot

Metabotropic glutamate receptor 4
type: ProteinReference
xref: uniprot Q68EF4 365
xref: PTHR24060:SF23
organism: Mus musculus

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot Q5ZM91 90
xref: PTHR11635:SF129
organism: Gallus gallus

mGluR 1/5
type: Protein
entity reference: mGluR 1/5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

EAAT
type: Protein
entity reference: EAAT
cellular location: Glia c8
comment: SPECIES_TYPE=PROTEIN

uniprot Q6P4V2 150
type: UnificationXref
id: Q6P4V2
db: uniprot

ncbitaxon 9913 25
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot A2AIR5 172
type: UnificationXref
id: A2AIR5
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 25

uniprot Q5R1P3 212
type: UnificationXref
id: Q5R1P3
db: uniprot

Vglut
type: ProteinReference
xref: P01038
standard name: Vesicular Glutamate Transporter
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Vesicular Glutamate Transporter Synonym: Vglut Accession: P01038
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group III pathway.PROTEIN.GENERIC.Vglut
member entity reference: Vesicular glutamate transporter 1
member entity reference: Solute carrier family 17 member 7
member entity reference: Uncharacterized protein

uniprot F1PUW7 119
type: UnificationXref
id: F1PUW7
db: uniprot

PTHR43642:SF2
type: RelationshipXref
id: PTHR43642:SF2
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q3W7 427
organism: Pan troglodytes

uniprot Q2HJD2 599
type: UnificationXref
id: Q2HJD2
db: uniprot

uniprot F7DNS6 267
type: UnificationXref
id: F7DNS6
db: uniprot

uniprot P17612 66
type: UnificationXref
id: P17612
db: uniprot

Glutamate s127 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Metabotropic glutamate receptor 7
type: ProteinReference
xref: uniprot Q68ED2 364
xref: PTHR24060:SF98
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q28H40 482
organism: Xenopus tropicalis

uniprot F1P0L4 550
type: UnificationXref
id: F1P0L4
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P30671 451
organism: Bos taurus

uniprot Q13224 208
type: UnificationXref
id: Q13224
db: uniprot

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P31324 75
organism: Mus musculus

Metabotropic glutamate receptor 8
type: ProteinReference
xref: uniprot P47743 359
xref: PTHR24060:SF26
organism: Mus musculus

G protein alpha i subunit
type: ProteinReference
xref: uniprot P20353 447
xref: PTHR10218:SF310
organism: Drosophila melanogaster

uniprot F7AF72 561
type: UnificationXref
id: F7AF72
db: uniprot

uniprot Q6TNT8 500
type: UnificationXref
id: Q6TNT8
db: uniprot

uniprot Q8MLZ3 101
type: UnificationXref
id: Q8MLZ3
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 376

Adenylate cyclase type 10
type: ProteinReference
xref: uniprot Q8C0T9 338
xref: PTHR16305:SF28
organism: Mus musculus

uniprot F5HH30 395
type: UnificationXref
id: F5HH30
db: uniprot

uniprot P63219 477
type: UnificationXref
id: P63219
db: uniprot

AGAP008039-PA (Fragment)
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot Q7Q3T7 96
organism: Anopheles gambiae

uniprot P42262 587
type: UnificationXref
id: P42262
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot F1A421 389
organism: Dictyostelium purpureum

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FB74 568
xref: PTHR18966:SF171
organism: Monodelphis domestica

Vglut
type: Protein
entity reference: Vglut
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

cAMP-dependent protein kinase catalytic subunit 1
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot P12370 60
organism: Drosophila melanogaster

uniprot F6TYP9 557
type: UnificationXref
id: F6TYP9
db: uniprot

uniprot C7G3L6 541
type: UnificationXref
id: C7G3L6
db: uniprot

Voltage-dependent R-type calcium channel subunit alpha-1E
type: ProteinReference
xref: PTHR45628:SF5
xref: uniprot Q07652 242
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7G7I9 420
organism: Ornithorhynchus anatinus

Glutamate receptor ionotropic, kainate 4
type: ProteinReference
xref: uniprot Q5IS46 600
xref: PTHR18966:SF171
organism: Pan troglodytes

uniprot P63045 302
type: UnificationXref
id: P63045
db: uniprot

uniprot A8X8S6 253
type: UnificationXref
id: A8X8S6
db: uniprot

PTHR45701:SF10
type: RelationshipXref
id: PTHR45701:SF10
db: PANTHER Family
relationship type: By Homology

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P31323 74
xref: PTHR11635:SF156
organism: Homo sapiens

AGAP002578-PB
type: ProteinReference
xref: uniprot F5HKU8 232
xref: PTHR45628:SF7
organism: Anopheles gambiae

uniprot F6Y7R9 558
type: UnificationXref
id: F6Y7R9
db: uniprot

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: uniprot P31321 73
xref: PTHR11635:SF126
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7CFG8 408
organism: Monodelphis domestica

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 6

ncbitaxon 665079 373
type: UnificationXref
id: 665079
db: ncbitaxon

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P12369 59
xref: PTHR11635:SF156
organism: Rattus norvegicus

mGluR 5
type: ProteinReference
xref: P01037
standard name: Metabotropic Glutamate Receptor 5
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group III pathway.PROTEIN.RECEPTOR.mGluR 5
comment: ENTITY_REFERENCE_NOTES= Long Name: Metabotropic Glutamate Receptor 5 Synonym: mGlu5,mGluR5 Accession: P01037
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Glutamate metabotropic receptor 5
member entity reference: Metabotropic glutamate receptor 5 isoform a
member entity reference: Metabotropic glutamate receptor 5
member entity reference: Uncharacterized protein

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P12367 56
organism: Mus musculus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P12368 57
organism: Rattus norvegicus

uniprot P63077 469
type: UnificationXref
id: P63077
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NWG3 155
xref: PTHR24060:SF30
organism: Gallus gallus

Glutamate receptor ionotropic, kainate 3
type: ProteinReference
xref: uniprot B1AS29 539
xref: PTHR18966:SF174
organism: Mus musculus

Glutamate receptor ionotropic, NMDA 2D
type: ProteinReference
evidence: Evidence 192
evidence: Evidence 193
evidence: Evidence 194
xref: uniprot Q62645 213
xref: PTHR18966:SF385
organism: Rattus norvegicus

uniprot Q61017 492
type: UnificationXref
id: Q61017
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot Q9VH76 330
xref: PTHR19305:SF14
organism: Drosophila melanogaster

Glutamate receptor 3
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot P19492 577
organism: Rattus norvegicus

Glutamate receptor 4
type: ProteinReference
xref: PTHR18966:SF100
xref: uniprot P19493 578
organism: Rattus norvegicus

Glutamate receptor 2
type: ProteinReference
evidence: Evidence 520
xref: uniprot P19491 576
xref: PTHR18966:SF99
organism: Rattus norvegicus

uniprot Q10914 593
type: UnificationXref
id: Q10914
db: uniprot

Gnb3 protein
type: ProteinReference
xref: uniprot Q6P025 495
organism: Danio rerio

Glutamate metabotropic receptor 8
type: ProteinReference
xref: uniprot E2RDG9 347
xref: PTHR24060:SF26
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
evidence: Evidence 520
xref: uniprot F1NKF1 548
xref: PTHR18966:SF99
organism: Gallus gallus

N-methyl-D-aspartate receptor type 1 subunit
type: ProteinReference
evidence: Evidence 168
xref: PTHR18966:SF377
xref: uniprot Q6R6I2 214
organism: Gallus gallus

uniprot A2VE57 537
type: UnificationXref
id: A2VE57
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1C2Q1 542
xref: PTHR18966:SF171
organism: Gallus gallus

Glutamate receptor 4
type: ProteinReference
xref: uniprot P48058 590
xref: PTHR18966:SF100
organism: Homo sapiens

Guanine nucleotide binding protein, beta subunit
type: ProteinReference
xref: uniprot E9FUX0 388
organism: Daphnia pulex

Glutamate receptor, ionotropic, kainate 1
type: ProteinReference
xref: PTHR18966:SF36
xref: uniprot F7BDN8 566
organism: Xenopus tropicalis

Vesicular glutamate transporter 1
type: ProteinReference
xref: PTHR11662:SF29
xref: uniprot Q62634 165
organism: Rattus norvegicus

uniprot E1BW98 380
type: UnificationXref
id: E1BW98
db: uniprot

uniprot A0A2I3S4R3 366
type: UnificationXref
id: A0A2I3S4R3
db: uniprot

uniprot P00517 46
type: UnificationXref
id: P00517
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 171
xref: PTHR18966:SF382
xref: uniprot F1MCL3 178
organism: Bos taurus

uniprot G7MRR5 355
type: UnificationXref
id: G7MRR5
db: uniprot

DISSOCIATION_LEFT__Complex__Vglut_Glutamate_-RIGHT__Glutamate-_Vglut-_r68
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 668
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 667
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 666
left: Complex (Vglut/Glutamate)
interaction type: DISSOCIATION
right: Vglut
right: Glutamate

uniprot A0A2I3SR99 251
type: UnificationXref
id: A0A2I3SR99
db: uniprot

Amino acid transporter
type: ProteinReference
xref: uniprot A0A2I3RPT6 109
xref: PTHR11958:SF93
organism: Pan troglodytes

Glutamate receptor 3.2
type: ProteinReference
xref: PTHR18966:SF422
xref: uniprot Q93YT1 605
organism: Arabidopsis thaliana

uniprot Q91ZU9 219
type: UnificationXref
id: Q91ZU9
db: uniprot

uniprot F1NU20 549
type: UnificationXref
id: F1NU20
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 397
organism: Monodelphis domestica

uniprot Q9W0N6 331
type: UnificationXref
id: Q9W0N6
db: uniprot

THO complex subunit, putative
type: ProteinReference
xref: uniprot B7Q3T6 375
organism: Ixodes scapularis

Glutamate receptor, ionotropic, N-methyl D-aspartate 1b
type: ProteinReference
evidence: Evidence 168
xref: uniprot Q6ZM67 215
xref: PTHR18966:SF497
organism: Danio rerio

uniprot F1N213 348
type: UnificationXref
id: F1N213
db: uniprot

uniprot Q9VH76 330
type: UnificationXref
id: Q9VH76
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XHP0 402
organism: Macaca mulatta

uniprot H2R1G3 38
type: UnificationXref
id: H2R1G3
db: uniprot

uniprot P46411 142
type: UnificationXref
id: P46411
db: uniprot

uniprot Q3T0Y8 312
type: UnificationXref
id: Q3T0Y8
db: uniprot

Glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P13861 63
type: UnificationXref
id: P13861
db: uniprot

uniprot Q803H5 507
type: UnificationXref
id: Q803H5
db: uniprot

Syntaxin-1A isoform 1
type: ProteinReference
xref: PTHR19957:SF84
xref: uniprot A0A1D5QEM1 247
organism: Macaca mulatta

uniprot P29829 450
type: UnificationXref
id: P29829
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot P10824 442
organism: Rattus norvegicus

uniprot P43004 139
type: UnificationXref
id: P43004
db: uniprot

Glutamate s30 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

uniprot A0A2I3TBK2 227
type: UnificationXref
id: A0A2I3TBK2
db: uniprot

uniprot A8WRW6 230
type: UnificationXref
id: A8WRW6
db: uniprot

uniprot F5HMS4 257
type: UnificationXref
id: F5HMS4
db: uniprot

uniprot F7AGW3 563
type: UnificationXref
id: F7AGW3
db: uniprot

Glutamate receptor 2
type: ProteinReference
evidence: Evidence 594
xref: uniprot Q10914 593
xref: PTHR18966:SF505
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
evidence: Evidence 520
xref: PTHR18966:SF99
xref: uniprot F6T423 555
organism: Xenopus tropicalis

uniprot F6Y3N2 404
type: UnificationXref
id: F6Y3N2
db: uniprot

uniprot Q20636 481
type: UnificationXref
id: Q20636
db: uniprot

uniprot P04899 438
type: UnificationXref
id: P04899
db: uniprot

ncbitaxon 7227 61
type: UnificationXref
id: 7227
db: ncbitaxon

Evidence 169
type: Evidence
evidence code: ISS
comment: Website http://harvester.embl.de/harvester/Q149/Q14957.htm

Evidence 168
type: Evidence
evidence code: ISS
comment: Website http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot H2RER5 40
xref: PTHR11635:SF156
organism: Pan troglodytes

uniprot P35439 199
type: UnificationXref
id: P35439
db: uniprot

uniprot P08752 439
type: UnificationXref
id: P08752
db: uniprot

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 642
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P17343 445
type: UnificationXref
id: P17343
db: uniprot

Glutamate s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PTHR24353:SF67
type: RelationshipXref
id: PTHR24353:SF67
db: PANTHER Family
relationship type: By Homology

uniprot F7FB74 568
type: UnificationXref
id: F7FB74
db: uniprot

Evidence 170
type: Evidence
evidence code: ISS
comment: Website http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 507
organism: Danio rerio

Evidence 173
type: Evidence
evidence code: ISS
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html

uniprot H2RER5 40
type: UnificationXref
id: H2RER5
db: uniprot

uniprot O60262 436
type: UnificationXref
id: O60262
db: uniprot

Evidence 171
type: Evidence
evidence code: ISS
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html

uniprot P50154 458
type: UnificationXref
id: P50154
db: uniprot

Glutamate ionotropic receptor NMDA type subunit 1
type: ProteinReference
evidence: Evidence 168
xref: PTHR18966:SF377
xref: uniprot G3N3K3 187
organism: Bos taurus

Glutamate
type: SmallMolecule
cellular location: synaptic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR18966:SF297
type: RelationshipXref
id: PTHR18966:SF297
db: PANTHER Family
relationship type: By Homology

uniprot Q01098 204
type: UnificationXref
id: Q01098
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q63666 318
xref: PTHR45701:SF1
organism: Rattus norvegicus

Glutamate receptor ionotropic, kainate 1
type: ProteinReference
xref: PTHR18966:SF36
xref: uniprot Q60934 601
organism: Mus musculus

uniprot P05987 50
type: UnificationXref
id: P05987
db: uniprot

uniprot E2R2S3 382
type: UnificationXref
id: E2R2S3
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3KRE3 483
organism: Rattus norvegicus

Glutamate receptor IB, isoform B
type: ProteinReference
xref: uniprot M9PHV5 575
xref: PTHR18966:SF505
organism: Drosophila melanogaster

uniprot A7EDU2 372
type: UnificationXref
id: A7EDU2
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot E2RHY4 386
organism: Canis lupus familiaris

uniprot Q0VFR6 305
type: UnificationXref
id: Q0VFR6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR21230:SF62
xref: uniprot A0A1L1RKZ9 250
organism: Gallus gallus

uniprot Q95135 153
type: UnificationXref
id: Q95135
db: uniprot

uniprot E2R9G5 384
type: UnificationXref
id: E2R9G5
db: uniprot

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa19 662
cellular location: Glia c8
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Glutamate receptor, ionotropic, AMPA 3a
type: ProteinReference
xref: PTHR18966:SF527
xref: uniprot A2CG69 536
organism: Danio rerio

PTHR24353:SF82
type: RelationshipXref
id: PTHR24353:SF82
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF36
xref: uniprot F7AGW3 563
organism: Macaca mulatta

Evidence 192
type: Evidence
evidence code: IC
comment: Website http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm

Excitatory amino acid transporter
type: ProteinReference
xref: uniprot Q10901 147
xref: PTHR11958:SF89
organism: Caenorhabditis elegans

ncbitaxon 6238 12
type: UnificationXref
id: 6238
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF28
xref: uniprot D3ZLD6 379
organism: Rattus norvegicus

Evidence 197
type: Evidence
evidence code: IC
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5PCI4 5
xref: PTHR11635:SF126
organism: Gallus gallus

Evidence 196
type: Evidence
evidence code: IC
comment: Website http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436

uniprot F1QA08 553
type: UnificationXref
id: F1QA08
db: uniprot

Evidence 194
type: Evidence
evidence code: IC
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html

uniprot F7HAK5 34
type: UnificationXref
id: F7HAK5
db: uniprot

Evidence 193
type: Evidence
evidence code: IC
comment: Website http://harvester.embl.de/harvester/Q149/Q14957.htm

Glutamate s128 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r70 698
type: Stoichiometry
physical entity: mGluR 5
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r70 699
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PTHR24353:SF37
type: RelationshipXref
id: PTHR24353:SF37
db: PANTHER Family
relationship type: By Homology

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 78

uniprot C7G3M9 343
type: UnificationXref
id: C7G3M9
db: uniprot

GDP s8 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

mGluR 1/5
type: Protein
entity reference: mGluR 1/5
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa26 618
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P19492 577
type: UnificationXref
id: P19492
db: uniprot

uniprot A5PKD6 371
type: UnificationXref
id: A5PKD6
db: uniprot

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 168
xref: uniprot Q05586 206
xref: PTHR18966:SF377
organism: Homo sapiens

SNARE Complex s13 sa12 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Glutamate receptor 1
type: ProteinReference
xref: uniprot Q03445 592
xref: PTHR18966:SF505
organism: Drosophila melanogaster

uniprot F7A943 266
type: UnificationXref
id: F7A943
db: uniprot

uniprot F2Z3T8 394
type: UnificationXref
id: F2Z3T8
db: uniprot

uniprot E2RHU1 544
type: UnificationXref
id: E2RHU1
db: uniprot

uniprot O18210 132
type: UnificationXref
id: O18210
db: uniprot

uniprot F1MCL3 178
type: UnificationXref
id: F1MCL3
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q0VFC4 478
organism: Xenopus tropicalis

Glutamate ionotropic receptor kainate type subunit 5
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot A0A2I3S1J9 528
organism: Pan troglodytes

uniprot F7CTP1 409
type: UnificationXref
id: F7CTP1
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6TH03 499
organism: Danio rerio

uniprot O00161 277
type: UnificationXref
id: O00161
db: uniprot

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot Q20636 481
organism: Caenorhabditis elegans

uniprot P11017 443
type: UnificationXref
id: P11017
db: uniprot

Probable glutamate receptor
type: ProteinReference
xref: PTHR18966:SF417
xref: uniprot A0A452J7P8 535
organism: Gallus gallus

uniprot A0A2I3T0G3 110
type: UnificationXref
id: A0A2I3T0G3
db: uniprot

Amino acid transporter
type: ProteinReference
xref: uniprot Q9N280 154
xref: PTHR11958:SF24
organism: Canis lupus familiaris

uniprot O15303 357
type: UnificationXref
id: O15303
db: uniprot

uniprot Q00959 200
type: UnificationXref
id: Q00959
db: uniprot

EAAT
type: Protein
entity reference: EAAT
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot Q28HP6 310
xref: PTHR19305:SF5
organism: Xenopus tropicalis

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
type: ProteinReference
xref: uniprot Q7ZW82 506
xref: PTHR10218:SF227
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot F7HAK5 34
organism: Macaca mulatta

TRANSPORT_LEFT__Glutamate-RIGHT__Glutamate-_r64
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 679
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 678
left: Glutamate
interaction type: TRANSPORT
right: Glutamate

uniprot P26308 448
type: UnificationXref
id: P26308
db: uniprot

uniprot Q00960 201
type: UnificationXref
id: Q00960
db: uniprot

Amino acid transporter
type: ProteinReference
xref: uniprot A0A3Q1MR13 112
xref: PTHR11958:SF93
organism: Bos taurus

PTHR45628:SF7
type: RelationshipXref
id: PTHR45628:SF7
db: PANTHER Family
relationship type: By Homology

uniprot H2R3A6 431
type: UnificationXref
id: H2R3A6
db: uniprot

PTHR45628:SF6
type: RelationshipXref
id: PTHR45628:SF6
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E1C795 381
organism: Gallus gallus

PTHR45628:SF5
type: RelationshipXref
id: PTHR45628:SF5
db: PANTHER Family
relationship type: By Homology

uniprot P49177 454
type: UnificationXref
id: P49177
db: uniprot

PTHR45628:SF3
type: RelationshipXref
id: PTHR45628:SF3
db: PANTHER Family
relationship type: By Homology

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa10 638
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot F6YEB6 125
type: UnificationXref
id: F6YEB6
db: uniprot

uniprot H2QZZ2 190
type: UnificationXref
id: H2QZZ2
db: uniprot

uniprot Q5R1X1 315
type: UnificationXref
id: Q5R1X1
db: uniprot

uniprot B2RSH2 374
type: UnificationXref
id: B2RSH2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF100
xref: uniprot F7AGS3 562
organism: Macaca mulatta

uniprot P42263 588
type: UnificationXref
id: P42263
db: uniprot

LD27967p
type: ProteinReference
xref: uniprot Q9W0N6 331
xref: PTHR21230:SF62
organism: Drosophila melanogaster

uniprot Q9MZL7 246
type: UnificationXref
id: Q9MZL7
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V8K2 423
organism: Rattus norvegicus

uniprot F7EBQ5 31
type: UnificationXref
id: F7EBQ5
db: uniprot

AGAP001384-PA
type: ProteinReference
xref: uniprot Q7PXF7 95
xref: PTHR24353:SF117
organism: Anopheles gambiae

HETERODIMER_ASSOCIATION_LEFT__Glutamate-_EAAT-RIGHT__Complex__EAAT_Glutamate_-_r69
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 664
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 663
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 665
left: EAAT
left: Glutamate
interaction type: HETERODIMER_ASSOCIATION
right: Complex (EAAT/Glutamate)

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot A7EDU2 372
organism: Sclerotinia sclerotiorum

uniprot P63096 471
type: UnificationXref
id: P63096
db: uniprot

Glutamate s10 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 171
xref: PTHR18966:SF382
xref: uniprot F6PGX6 181
organism: Monodelphis domestica

cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B
type: ProteinReference
xref: uniprot Q8MM62 102
xref: PTHR11635:SF159
organism: Dictyostelium discoideum

uniprot F6PGC8 396
type: UnificationXref
id: F6PGC8
db: uniprot

SNAP29 isoform 1
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot H2QLA1 272
organism: Pan troglodytes

uniprot P24942 136
type: UnificationXref
id: P24942
db: uniprot

mGluR4/6/7/8
type: ProteinReference
xref: P01044
standard name: Metabotropic Glutamate Receptor 4, 6, 7, 8
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group III pathway.PROTEIN.RECEPTOR.mGluR4/6/7/8
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Metabotropic glutamate receptor 7
member entity reference: Glutamate metabotropic receptor 8
member entity reference: Uncharacterized protein
member entity reference: Metabotropic glutamate receptor 4
member entity reference: Metabotropic glutamate receptor 6
member entity reference: GRM7 isoform 3
member entity reference: Metabotropic glutamate receptor 8
member entity reference: Glutamate metabotropic receptor 6
member entity reference: GRM4 isoform 4
member entity reference: Glutamate metabotropic receptor 7
member entity reference: Glutamate metabotropic receptor 4

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 51

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: uniprot P36600 77
xref: PTHR11635:SF152
organism: Schizosaccharomyces pombe

Glutamate ionotropic receptor NMDA type subunit 1
type: ProteinReference
evidence: Evidence 168
xref: PTHR18966:SF377
xref: uniprot F7CS79 185
organism: Xenopus tropicalis

SNARE Complex
type: ProteinReference
xref: P01042
standard name: N-ethylmaleimide-sensitive factor attachment protein receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: N-ethylmaleimide-sensitive factor attachment protein receptor Synonym: SNARE Accession: P01042
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group III pathway.PROTEIN.GENERIC.SNARE Complex
member entity reference: Vesicle-associated membrane protein 2
member entity reference: Synaptosomal-associated protein
member entity reference: Syntaxin-1B
member entity reference: Vesicle-associated membrane protein 3
member entity reference: Vesicle-associated membrane protein 1
member entity reference: Vesicle-associated membrane protein 8
member entity reference: Syntaxin-1A isoform 1
member entity reference: STX1A isoform 3
member entity reference: Synaptosomal-associated protein 25
member entity reference: VAMP3 isoform 1
member entity reference: SNAP25 homologous protein SNAP29
member entity reference: Neuronal synaptobrevin, isoform J
member entity reference: Vesicle associated membrane protein 8
member entity reference: Synaptobrevin-1
member entity reference: LD03592p
member entity reference: SNAP25 homologous protein SNAP33
member entity reference: Synaptosomal-associated protein 25-B
member entity reference: Uncharacterized protein
member entity reference: Vesicle transport through interaction with t-SNAREs homolog 1A
member entity reference: VTI1A isoform 1
member entity reference: Syntaxin 1A
member entity reference: Syntaxin 1B
member entity reference: SNAP29 isoform 1
member entity reference: Synaptosomal-associated protein 25-A
member entity reference: Synaptosomal-associated protein 23
member entity reference: Soluble NSF attachment protein 29
member entity reference: Synaptobrevin homolog 1
member entity reference: Syntaxin-1A
member entity reference: AGAP009322-PA
member entity reference: VAMP2 isoform 3
member entity reference: t-SNARE protein aex-4
member entity reference: Putative synaptobrevin homologue SNC1/2 (Eurofung)
member entity reference: Vesicle associated membrane protein 1
member entity reference: LD27967p
member entity reference: Synaptosomal-associated protein 29

uniprot C7G3N0 344
type: UnificationXref
id: C7G3N0
db: uniprot

uniprot F6Z5I2 265
type: UnificationXref
id: F6Z5I2
db: uniprot

uniprot H2QTV8 222
type: UnificationXref
id: H2QTV8
db: uniprot

uniprot D3ZLD6 379
type: UnificationXref
id: D3ZLD6
db: uniprot

uniprot P48058 590
type: UnificationXref
id: P48058
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7E376 433
organism: Monodelphis domestica

uniprot E2R907 255
type: UnificationXref
id: E2R907
db: uniprot

uniprot O55017 236
type: UnificationXref
id: O55017
db: uniprot

Glutamate metabotropic receptor 8
type: ProteinReference
xref: PTHR24060:SF26
xref: uniprot F6PLI7 350
organism: Ornithorhynchus anatinus

uniprot A0A1D5QEM1 247
type: UnificationXref
id: A0A1D5QEM1
db: uniprot

G Protein s7 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

uniprot F5HKU8 232
type: UnificationXref
id: F5HKU8
db: uniprot

uniprot Q9GNR4 105
type: UnificationXref
id: Q9GNR4
db: uniprot

Complex (GTP/G-Protein)
type: Complex
component stoichiometry: GTP s3 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s5 sa4 STOICHIOMETRY ID COMPLEX
component: GTP
component: G-Protein
feature: COMPLEX BINDING FEATURE s73 a83 643
feature: ACTIVE 106
feature: COMPLEX BINDING FEATURE s73 a83 641
cellular location: axon terminus

uniprot Q13002 595
type: UnificationXref
id: Q13002
db: uniprot

uniprot Q60934 601
type: UnificationXref
id: Q60934
db: uniprot

Complex (NMDA/Glutamate)
type: Complex
component stoichiometry: Glutamate s28 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: NMDA s27 sa24 STOICHIOMETRY ID COMPLEX
component: Glutamate
component: NMDA
feature: COMPLEX BINDING FEATURE s123 a133 621
feature: COMPLEX BINDING FEATURE s123 a133 623
cellular location: cytosol

uniprot P68181 80
type: UnificationXref
id: P68181
db: uniprot

Complex (mGluR4/6/ 7/8/ Glutamate)
type: Complex
component stoichiometry: mGluR4 6 7 8 s1 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glutamate s2 sa2 STOICHIOMETRY ID COMPLEX
component: Glutamate
component: mGluR4/6/7/8
feature: COMPLEX BINDING FEATURE s35 a37 631
feature: COMPLEX BINDING FEATURE s35 a37 629
feature: ACTIVE 106
cellular location: axon terminus

Metabotropic glutamate receptor 8
type: ProteinReference
xref: uniprot O00222 356
xref: PTHR24060:SF26
organism: Homo sapiens

uniprot Q6P025 495
type: UnificationXref
id: Q6P025
db: uniprot

uniprot Q01386 83
type: UnificationXref
id: Q01386
db: uniprot

uniprot P12849 62
type: UnificationXref
id: P12849
db: uniprot

uniprot P08754 441
type: UnificationXref
id: P08754
db: uniprot

uniprot Q9W1I8 332
type: UnificationXref
id: Q9W1I8
db: uniprot

uniprot E1BLE8 346
type: UnificationXref
id: E1BLE8
db: uniprot

uniprot Q551V8 337
type: UnificationXref
id: Q551V8
db: uniprot

uniprot Q9Z286 341
type: UnificationXref
id: Q9Z286
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

uniprot P62880 467
type: UnificationXref
id: P62880
db: uniprot

uniprot F7F746 567
type: UnificationXref
id: F7F746
db: uniprot

uniprot F7CSQ4 127
type: UnificationXref
id: F7CSQ4
db: uniprot

ncbitaxon 284812 78
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot Q6DH55 494
type: UnificationXref
id: Q6DH55
db: uniprot

PRKACG isoform 1
type: ProteinReference
xref: uniprot H2QXB9 37
xref: PTHR24353:SF137
organism: Pan troglodytes

uniprot Q8TCU5 217
type: UnificationXref
id: Q8TCU5
db: uniprot

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 168
xref: PTHR18966:SF377
xref: uniprot Q5R1P0 211
organism: Canis lupus familiaris

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 171
xref: uniprot Q5R1P3 212
xref: PTHR18966:SF382
organism: Canis lupus familiaris

Ca2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

Glutamate ionotropic receptor AMPA type subunit 3
type: ProteinReference
xref: PTHR18966:SF151
xref: uniprot E2RHU1 544
organism: Canis lupus familiaris

NMDA class glutamate Receptor
type: ProteinReference
evidence: Evidence 168
xref: PTHR18966:SF377
xref: uniprot G5EGQ9 188
organism: Caenorhabditis elegans

AC
type: Protein
entity reference: AC
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot Q14833 362
type: UnificationXref
id: Q14833
db: uniprot

NMDA receptor 2, isoform C
type: ProteinReference
xref: PTHR18966:SF391
xref: uniprot Q9W581 220
organism: Drosophila melanogaster

uniprot Q5I0F6 89
type: UnificationXref
id: Q5I0F6
db: uniprot

uniprot Q8MJ44 100
type: UnificationXref
id: Q8MJ44
db: uniprot

Voltage-dependent R-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot A0A3Q1LZY8 229
xref: PTHR45628:SF5
organism: Bos taurus

uniprot F7G4Q0 32
type: UnificationXref
id: F7G4Q0
db: uniprot

uniprot F7FY70 569
type: UnificationXref
id: F7FY70
db: uniprot

uniprot O00555 235
type: UnificationXref
id: O00555
db: uniprot

uniprot P62874 465
type: UnificationXref
id: P62874
db: uniprot

uniprot Q90Z40 511
type: UnificationXref
id: Q90Z40
db: uniprot

uniprot O00341 131
type: UnificationXref
id: O00341
db: uniprot

uniprot P22694 70
type: UnificationXref
id: P22694
db: uniprot

uniprot Q16099 597
type: UnificationXref
id: Q16099
db: uniprot

cGMP-dependent 3',5'-cGMP phosphodiesterase A
type: ProteinReference
xref: PTHR11635:SF157
xref: uniprot Q8MLZ3 101
organism: Dictyostelium discoideum

AGAP001478-PA
type: ProteinReference
evidence: Evidence 168
xref: PTHR18966:SF377
xref: uniprot Q7PXM3 216
organism: Anopheles gambiae