uniprot Q5BK52 380
type: UnificationXref
id: Q5BK52
db: uniprot

uniprot F6UFJ7 247
type: UnificationXref
id: F6UFJ7
db: uniprot

uniprot Q8C0T9 420
type: UnificationXref
id: Q8C0T9
db: uniprot

Neuronal synaptobrevin, isoform J
type: ProteinReference
xref: uniprot M9PE71 261
xref: PTHR45701:SF3
organism: Drosophila melanogaster

uniprot H2QLA1 258
type: UnificationXref
id: H2QLA1
db: uniprot

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: PTHR45628:SF6
xref: uniprot Q02294 411
organism: Rattus norvegicus

G protein subunit alpha i3
type: ProteinReference
xref: uniprot H2PZK9 95
xref: PTHR10218:SF230
organism: Pan troglodytes

uniprot A5D7D8 222
type: UnificationXref
id: A5D7D8
db: uniprot

uniprot F7A943 252
type: UnificationXref
id: F7A943
db: uniprot

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 4

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q5ZJ03 185
organism: Gallus gallus

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P07278 352
organism: Saccharomyces cerevisiae

PTHR10218:SF331
type: RelationshipXref
id: PTHR10218:SF331
db: PANTHER Family
relationship type: By Homology

uniprot F1P977 53
type: UnificationXref
id: F1P977
db: uniprot

G protein subunit alpha i1
type: ProteinReference
xref: uniprot F1P977 53
xref: PTHR10218:SF227
organism: Canis lupus familiaris

uniprot P08753 113
type: UnificationXref
id: P08753
db: uniprot

uniprot Q07652 413
type: UnificationXref
id: Q07652
db: uniprot

G protein subunit alpha transducin 2
type: ProteinReference
xref: uniprot H2PZL0 96
xref: PTHR10218:SF68
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IFL6 18
organism: Bos taurus

GO GO:0008021 2
type: UnificationXref
id: GO:0008021
db: GO

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RBE7 42
organism: Canis lupus familiaris

uniprot O35526 264
type: UnificationXref
id: O35526
db: uniprot

uniprot O00555 406
type: UnificationXref
id: O00555
db: uniprot

Metabotropic glutamate receptor 3
type: ProteinReference
xref: uniprot Q14832 233
xref: PTHR24060:SF160
organism: Homo sapiens

DISSOCIATION_LEFT__Complex__mGluR2_3__Glutamate_G_protein__GDP_-_GTP-RIGHT__Complex__GTP_G_protein_-_GDP-_Complex__mGluR2_3__Glutamate_-_r54
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 455
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 453
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 452
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 451
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 454
left: Complex (mGluR2/3/ Glutamate/G-protein/ GDP)
left: GTP
interaction type: DISSOCIATION
right: Complex (mGluR2/3/ Glutamate)
right: GDP
right: Complex (GTP/G-protein)

uniprot P61953 152
type: UnificationXref
id: P61953
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 8

Uncharacterized protein
type: ProteinReference
xref: PTHR24060:SF160
xref: uniprot F6V5G0 225
organism: Monodelphis domestica

PTHR10218:SF340
type: RelationshipXref
id: PTHR10218:SF340
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot F6XYX9 249
organism: Monodelphis domestica

uniprot H2Q1D9 97
type: UnificationXref
id: H2Q1D9
db: uniprot

PRKACB isoform 3
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot H2R1G3 340
organism: Pan troglodytes

uniprot H2QXB9 339
type: UnificationXref
id: H2QXB9
db: uniprot

ncbitaxon 3702 139
type: UnificationXref
id: 3702
db: ncbitaxon

mGluR2 3 s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR2/3
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P17612 362
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 158
organism: Homo sapiens

PTHR19305:SF14
type: RelationshipXref
id: PTHR19305:SF14
db: PANTHER Family
relationship type: By Homology

ncbitaxon 10116 33
type: UnificationXref
id: 10116
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 157
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 155
organism: Canis lupus familiaris

uniprot Q02294 411
type: UnificationXref
id: Q02294
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 156
organism: Homo sapiens

uniprot Q7PXP3 199
type: UnificationXref
id: Q7PXP3
db: uniprot

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot P62881 160
organism: Mus musculus

PTHR10218:SF310
type: RelationshipXref
id: PTHR10218:SF310
db: PANTHER Family
relationship type: By Homology

uniprot Q9W3J1 219
type: UnificationXref
id: Q9W3J1
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 159
organism: Mus musculus

Protein kinase cAMP-activated catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot F6T0T9 332
organism: Xenopus tropicalis

uniprot O55017 407
type: UnificationXref
id: O55017
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot F6UFJ7 247
xref: PTHR19305:SF9
organism: Macaca mulatta

uniprot Q9VH76 315
type: UnificationXref
id: Q9VH76
db: uniprot

uniprot Q8CXT1 389
type: UnificationXref
id: Q8CXT1
db: uniprot

uniprot F6XWE8 71
type: UnificationXref
id: F6XWE8
db: uniprot

PTHR19305:SF24
type: RelationshipXref
id: PTHR19305:SF24
db: PANTHER Family
relationship type: By Homology

PTHR16305:SF28
type: RelationshipXref
id: PTHR16305:SF28
db: PANTHER Family
relationship type: By Homology

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 57

PTHR19305:SF25
type: RelationshipXref
id: PTHR19305:SF25
db: PANTHER Family
relationship type: By Homology

PRKAR1A isoform 12
type: ProteinReference
xref: uniprot H2R3M7 341
xref: PTHR11635:SF129
organism: Pan troglodytes

Gnai3 protein
type: ProteinReference
xref: uniprot A9JTC8 25
xref: PTHR10218:SF230
organism: Danio rerio

ncbitaxon 7719 211
type: UnificationXref
id: 7719
db: ncbitaxon

uniprot Q02641 412
type: UnificationXref
id: Q02641
db: uniprot

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa6 424
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A2I3TUD1 16
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

uniprot P18489 269
type: UnificationXref
id: P18489
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 154
organism: Bos taurus

uniprot E2R9G5 41
type: UnificationXref
id: E2R9G5
db: uniprot

G protein s11 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-protein
stoichiometric coefficient: 1.0

uniprot Q5XGD8 184
type: UnificationXref
id: Q5XGD8
db: uniprot

uniprot Q8MJ44 391
type: UnificationXref
id: Q8MJ44
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot F7CTP1 78
organism: Macaca mulatta

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60879 277
xref: PTHR19305:SF5
organism: Mus musculus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60878 276
xref: PTHR19305:SF5
organism: Gallus gallus

Putative synaptobrevin homologue SNC1/2 (Eurofung)
type: ProteinReference
xref: uniprot Q5ASG1 300
organism: Emericella nidulans

Guanine nucleotide binding protein, beta 3
type: ProteinReference
xref: uniprot Q5XGD8 184
organism: Xenopus tropicalis

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60877 275
organism: Macaca mulatta

GTP s7 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot P61267 282
type: UnificationXref
id: P61267
db: uniprot

uniprot F6PVT7 59
type: UnificationXref
id: F6PVT7
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 11

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60880 278
xref: PTHR19305:SF5
organism: Homo sapiens

Guanine nucleotide-binding protein G(O) subunit alpha 1
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot E9H7Z0 48
organism: Daphnia pulex

Vesicle-associated membrane protein 3
type: ProteinReference
xref: uniprot Q2KJD2 298
xref: PTHR45701:SF6
organism: Bos taurus

uniprot P63215 166
type: UnificationXref
id: P63215
db: uniprot

PARTICIPANT STOICHIOMETRY r56 471
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r56 470
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Glutamate s10 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P68182 374
xref: PTHR24353:SF116
organism: Rattus norvegicus

uniprot P49177 138
type: UnificationXref
id: P49177
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P68181 373
organism: Mus musculus

uniprot P61265 280
type: UnificationXref
id: P61265
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63044 287
organism: Mus musculus

uniprot H2QNS5 101
type: UnificationXref
id: H2QNS5
db: uniprot

uniprot A4IFL6 18
type: UnificationXref
id: A4IFL6
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63045 288
organism: Rattus norvegicus

uniprot P68181 373
type: UnificationXref
id: P68181
db: uniprot

uniprot P04696 109
type: UnificationXref
id: P04696
db: uniprot

uniprot E9AFM1 325
type: UnificationXref
id: E9AFM1
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Glutamate-_Complex__mGluR2_3__G_protein_GDP_-RIGHT__Complex__mGluR2_3__Glutamate_G_protein__GDP_-_r53
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 458
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 456
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 457
left: Glutamate
left: Complex (mGluR2/3/ G-protein/GDP)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (mGluR2/3/ Glutamate/G-protein/ GDP)

uniprot A0A1D5PCI4 320
type: UnificationXref
id: A0A1D5PCI4
db: uniprot

Synaptobrevin-1
type: ProteinReference
xref: uniprot O02495 263
xref: PTHR45701:SF3
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot Q5E9F0 182
organism: Bos taurus

uniprot Q7Q8S4 205
type: UnificationXref
id: Q7Q8S4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZSF0 31
organism: Branchiostoma floridae

Syntaxin 1A
type: ProteinReference
xref: uniprot Q0VFR6 291
xref: PTHR19957:SF84
organism: Xenopus tropicalis

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot Q6TNT8 198
organism: Danio rerio

uniprot E2RRD1 324
type: UnificationXref
id: E2RRD1
db: uniprot

uniprot A8WRW6 401
type: UnificationXref
id: A8WRW6
db: uniprot

axon terminus
type: CellularLocationVocabulary
xref: GO GO:0043679 3

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_r31
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 467
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 466
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

uniprot P28052 129
type: UnificationXref
id: P28052
db: uniprot

uniprot Q7Q6D4 203
type: UnificationXref
id: Q7Q6D4
db: uniprot

ncbitaxon 227321 301
type: UnificationXref
id: 227321
db: ncbitaxon

Vesicle-associated membrane protein 8 (Endobrevin)
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q7ZUC1 307
organism: Danio rerio

uniprot A0A1D5Q7C3 397
type: UnificationXref
id: A0A1D5Q7C3
db: uniprot

uniprot F7EP58 254
type: UnificationXref
id: F7EP58
db: uniprot

Protein kinase A catalytic subunit
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q27687 378
organism: Leishmania major

uniprot Q9UK08 218
type: UnificationXref
id: Q9UK08
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63027 286
organism: Homo sapiens

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63026 285
organism: Bos taurus

uniprot P12849 358
type: UnificationXref
id: P12849
db: uniprot

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: PTHR45628:SF3
xref: uniprot P97445 409
organism: Mus musculus

cAMP
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q18434 175
type: UnificationXref
id: Q18434
db: uniprot

Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
type: ProteinReference
xref: uniprot F1QEC8 328
xref: PTHR11635:SF129
organism: Danio rerio

ncbitaxon 7165 200
type: UnificationXref
id: 7165
db: ncbitaxon

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63024 283
organism: Mus musculus

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63025 284
organism: Rattus norvegicus

uniprot F2Z3T8 55
type: UnificationXref
id: F2Z3T8
db: uniprot

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 58
organism: Ornithorhynchus anatinus

Metabotropic glutamate receptor group II pathway
type: Pathway
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r57
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_r31
pathway component: HETERODIMER_ASSOCIATION_LEFT__Glutamate-_Complex__mGluR2_3__G_protein_GDP_-RIGHT__Complex__mGluR2_3__Glutamate_G_protein__GDP_-_r53
pathway component: TRANSCRIPTION_LEFT__BDNF-RIGHT__BDNF-_re12
pathway component: TRANSPORT_LEFT__Glutamate-RIGHT__Glutamate-_r52
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r51
pathway component: STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r56
pathway component: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_r55
pathway component: DISSOCIATION_LEFT__Complex__mGluR2_3__Glutamate_G_protein__GDP_-_GTP-RIGHT__Complex__GTP_G_protein_-_GDP-_Complex__mGluR2_3__Glutamate_-_r54
pathway component: HETERODIMER_ASSOCIATION_LEFT__SNARE_Complex-_Ca2_PLUS_-RIGHT__Complex__SNARE_Complex_Ca2_PLUS__-_r58
xref: PANTHER Pathway P00040 1
comment: MODEL_NOTES=Panther Pathway: P00040 Group II Metabotropic Glutamate Receptors are composed of two receptor proteins, mGlu2 and mGlu3, which are negatively coupled to PKA and intracellular cAMP signalling. These receptors are found in forebrain and cerebellum. Evidence suggests that glutamatergic neuronal transmission is involved in psychiatric and neurological disorders and that drugs that target glutamate systems may serve as novel therapeutics in humans. For example, agonists for group II mGlu receptors (mGlu2 and mGlu3) have been shown to be anxiolytic in certain animal models and have shown promise in early human trials. Lilly is developing LY-354740, the lead compound in a series of derivatives of the metabotropic glutamate receptor group II agonist L-CCG-1, for the potential treatment of anxiety. Website=http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12789623 Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14684454 PMID: 12789623 PMID: 14684454

Syntaxin-1A
type: ProteinReference
xref: PTHR19957:SF84
xref: uniprot Q16623 293
organism: Homo sapiens

ncbitaxon 6945 28
type: UnificationXref
id: 6945
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R9G5 41
organism: Canis lupus familiaris

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot O70404 267
xref: PTHR45701:SF7
organism: Mus musculus

uniprot Q27687 378
type: UnificationXref
id: Q27687
db: uniprot

uniprot O44419 265
type: UnificationXref
id: O44419
db: uniprot

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot O14775 107
organism: Homo sapiens

GRM2 isoform 3
type: ProteinReference
xref: uniprot H2R892 229
xref: PTHR24060:SF147
organism: Pan troglodytes

VAMP2 isoform 3
type: ProteinReference
xref: uniprot H2RCB8 260
xref: PTHR45701:SF5
organism: Pan troglodytes

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot F6Z5I2 251
xref: PTHR45701:SF7
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot F6RIM7 61
organism: Monodelphis domestica

uniprot P62881 160
type: UnificationXref
id: P62881
db: uniprot

TRANSCRIPTION_LEFT__BDNF-RIGHT__BDNF-_re12
type: TemplateReaction
product: BDNF
xref: TRANSCRIPTION
participant: BDNF
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 39
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R2S3 37
organism: Canis lupus familiaris

uniprot Q6PBR4 194
type: UnificationXref
id: Q6PBR4
db: uniprot

MODULATION
type: RelationshipTypeVocabulary

SNARE Complex
type: Protein
entity reference: SNARE Complex
feature: SNARE Complex s61 a95 rs1
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 63

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F8W3G9 92
organism: Danio rerio

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
type: ProteinReference
xref: uniprot Q6DBV8 383
xref: PTHR24353:SF135
organism: Danio rerio

uniprot Q5ZJ03 185
type: UnificationXref
id: Q5ZJ03
db: uniprot

uniprot F7H6T2 336
type: UnificationXref
id: F7H6T2
db: uniprot

Protein kinase, cAMP-dependent, catalytic, beta a
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot Q7T374 388
organism: Danio rerio

G protein subunit alpha transducin 2
type: ProteinReference
xref: PTHR10218:SF68
xref: uniprot D4AA42 34
organism: Rattus norvegicus

uniprot A0A2I3TFM8 15
type: UnificationXref
id: A0A2I3TFM8
db: uniprot

uniprot H9EQQ4 344
type: UnificationXref
id: H9EQQ4
db: uniprot

GDP
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2QUQ1 259
type: UnificationXref
id: H2QUQ1
db: uniprot

G protein subunit alpha i2
type: ProteinReference
xref: uniprot H2QMN4 100
xref: PTHR10218:SF73
organism: Pan troglodytes

ncbitaxon 10090 8
type: UnificationXref
id: 10090
db: ncbitaxon

SNARE Complex s13 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SNARE Complex
stoichiometric coefficient: 1.0

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot O95721 268
xref: PTHR19305:SF9
organism: Homo sapiens

Protein kinase cAMP-dependent type II regulatory subunit alpha
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot E2RRD1 324
organism: Canis lupus familiaris

Protein kinase cAMP-dependent type I regulatory subunit alpha
type: ProteinReference
xref: uniprot F6R7N8 331
xref: PTHR11635:SF129
organism: Monodelphis domestica

Brain-derived neurotrophic factor
type: DnaReference
xref: PTHR11589:SF3
organism: Danio rerio

Guanine nucleotide-binding protein alpha-17 subunit
type: ProteinReference
xref: PTHR10218:SF215
xref: uniprot Q18434 175
organism: Caenorhabditis elegans

PANTHER Pathway P00040 1
type: UnificationXref
id: P00040
db: PANTHER Pathway

DISSOCIATION
type: RelationshipTypeVocabulary

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot Q9DC51 216
organism: Mus musculus

uniprot P59215 150
type: UnificationXref
id: P59215
db: uniprot

uniprot F6Q503 329
type: UnificationXref
id: F6Q503
db: uniprot

uniprot F6UBJ8 246
type: UnificationXref
id: F6UBJ8
db: uniprot

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot A8XW88 322
organism: Caenorhabditis briggsae

uniprot P60879 277
type: UnificationXref
id: P60879
db: uniprot

Metabotropic glutamate receptor 2
type: ProteinReference
xref: uniprot P31421 230
xref: PTHR24060:SF147
organism: Rattus norvegicus

uniprot F7H6T7 91
type: UnificationXref
id: F7H6T7
db: uniprot

Metabotropic glutamate receptor 3
type: ProteinReference
xref: PTHR24060:SF160
xref: uniprot P31422 231
organism: Rattus norvegicus

uniprot Q7T374 388
type: UnificationXref
id: Q7T374
db: uniprot

Adenylate cyclase type 10
type: ProteinReference
xref: PTHR16305:SF28
xref: uniprot H2Q0J3 419
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50150 142
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot P50151 143
organism: Homo sapiens

Calcium voltage-gated channel auxiliary subunit beta 1
type: ProteinReference
xref: PTHR11824:SF17
xref: uniprot A0A2I3TBK2 398
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot P50154 145
organism: Bos taurus

uniprot Q63666 305
type: UnificationXref
id: Q63666
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50153 144
organism: Mus musculus

uniprot P52287 146
type: UnificationXref
id: P52287
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot P50146 140
xref: PTHR10218:SF227
organism: Gallus gallus

uniprot A7EDU2 22
type: UnificationXref
id: A7EDU2
db: uniprot

uniprot F7A472 75
type: UnificationXref
id: F7A472
db: uniprot

uniprot Q15878 414
type: UnificationXref
id: Q15878
db: uniprot

Guanine nucleotide-binding protein G(t) subunit alpha-2
type: ProteinReference
xref: uniprot P50149 141
xref: PTHR10218:SF68
organism: Mus musculus

uniprot F5HH30 56
type: UnificationXref
id: F5HH30
db: uniprot

uniprot P62879 158
type: UnificationXref
id: P62879
db: uniprot

uniprot P68182 374
type: UnificationXref
id: P68182
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot Q01386 376
organism: Neurospora crassa

uniprot F7F580 84
type: UnificationXref
id: F7F580
db: uniprot

Complex (GTP/G-protein)
type: Complex
component stoichiometry: G protein s8 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s7 sa6 STOICHIOMETRY ID COMPLEX
component: GTP
component: G-protein
feature: COMPLEX BINDING FEATURE s71 a84 423
feature: ACTIVE 319
feature: COMPLEX BINDING FEATURE s71 a84 425
cellular location: axon terminus

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF126
xref: uniprot P12849 358
organism: Mus musculus

G protein alpha subunit Gi isoform X2
type: ProteinReference
xref: uniprot Q8WSS1 210
xref: PTHR10218:SF310
organism: Ciona intestinalis

uniprot Q14832 233
type: UnificationXref
id: Q14832
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P27791 365
organism: Rattus norvegicus

uniprot Q9CXP8 215
type: UnificationXref
id: Q9CXP8
db: uniprot

uniprot Q6DH55 190
type: UnificationXref
id: Q6DH55
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YMH2 250
xref: PTHR45701:SF6
organism: Macaca mulatta

uniprot P12367 354
type: UnificationXref
id: P12367
db: uniprot

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: PTHR45628:SF3
xref: uniprot O00555 406
organism: Homo sapiens

STATE_TRANSITION
type: RelationshipTypeVocabulary

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HBW2 404
xref: PTHR11824:SF17
organism: Macaca mulatta

uniprot A5PEW5 240
type: UnificationXref
id: A5PEW5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF334
xref: uniprot F7DNS6 253
organism: Macaca mulatta

PTHR10218:SF302
type: RelationshipXref
id: PTHR10218:SF302
db: PANTHER Family
relationship type: By Homology

uniprot F7BB02 76
type: UnificationXref
id: F7BB02
db: uniprot

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q9BV40 309
xref: PTHR45701:SF7
organism: Homo sapiens

uniprot F1QEC8 328
type: UnificationXref
id: F1QEC8
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__SNARE_Complex-_Ca2_PLUS_-RIGHT__Complex__SNARE_Complex_Ca2_PLUS__-_r58
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 465
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 463
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 464
left: SNARE Complex
left: Ca2+
interaction type: HETERODIMER_ASSOCIATION
right: Complex (SNARE Complex/Ca2+)

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot F6WM87 333
xref: PTHR11635:SF129
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot F7A943 252
organism: Monodelphis domestica

Soluble NSF attachment protein 29
type: ProteinReference
xref: uniprot P83351 289
xref: PTHR19305:SF9
organism: Caenorhabditis elegans

uniprot P62873 156
type: UnificationXref
id: P62873
db: uniprot

uniprot F7HBW2 404
type: UnificationXref
id: F7HBW2
db: uniprot

Prkar1a protein
type: ProteinReference
xref: uniprot Q5I0F6 381
xref: PTHR11635:SF129
organism: Danio rerio

uniprot P22694 364
type: UnificationXref
id: P22694
db: uniprot

uniprot P63025 284
type: UnificationXref
id: P63025
db: uniprot

uniprot P63218 169
type: UnificationXref
id: P63218
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot H2Q9G5 99
organism: Pan troglodytes

Brain-derived neurotrophic factor
type: DnaReference
xref: PTHR11589:SF3
organism: Bos taurus

uniprot C3ZSF0 31
type: UnificationXref
id: C3ZSF0
db: uniprot

uniprot Q9DC51 216
type: UnificationXref
id: Q9DC51
db: uniprot

uniprot P08752 112
type: UnificationXref
id: P08752
db: uniprot

uniprot E9H7Z0 48
type: UnificationXref
id: E9H7Z0
db: uniprot

Metabotropic glutamate receptor 2
type: ProteinReference
xref: PTHR24060:SF147
xref: uniprot Q14416 232
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63219 170
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 169
organism: Homo sapiens

G01540
type: UnificationXref
id: G01540
db: PANTHER Pathway Component

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot F6Q503 329
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63217 168
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63216 167
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 166
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63214 165
organism: Bos taurus

uniprot P26308 128
type: UnificationXref
id: P26308
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 242

uniprot A8X8S6 241
type: UnificationXref
id: A8X8S6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q15KE4 174
organism: Danio rerio

uniprot H2Q995 257
type: UnificationXref
id: H2Q995
db: uniprot

uniprot P31323 368
type: UnificationXref
id: P31323
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 121

uniprot P91645 408
type: UnificationXref
id: P91645
db: uniprot

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot P29829 131
organism: Drosophila melanogaster

Syntaxin 1B
type: ProteinReference
xref: PTHR19957:SF334
xref: uniprot F7EP58 254
organism: Xenopus tropicalis

uniprot Q2KJD2 298
type: UnificationXref
id: Q2KJD2
db: uniprot

G protein subunit alpha i1
type: ProteinReference
xref: uniprot A0A2I3S4R3 14
xref: PTHR10218:SF227
organism: Pan troglodytes

uniprot O70404 267
type: UnificationXref
id: O70404
db: uniprot

uniprot Q80SZ7 209
type: UnificationXref
id: Q80SZ7
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7F580 84
organism: Macaca mulatta

mGluR2/3
type: Protein
entity reference: mGluR2/3
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 446
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot Q3ZB92 379
type: UnificationXref
id: Q3ZB92
db: uniprot

PTHR19957:SF334
type: RelationshipXref
id: PTHR19957:SF334
db: PANTHER Family
relationship type: By Homology

G protein subunit alpha o1
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot A0A2I3TFM8 15
organism: Pan troglodytes

uniprot P05131 349
type: UnificationXref
id: P05131
db: uniprot

uniprot P31109 271
type: UnificationXref
id: P31109
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot Q9CXP8 215
organism: Mus musculus

By Homology
type: RelationshipTypeVocabulary

Adenylate cyclase type 10
type: ProteinReference
xref: PTHR16305:SF28
xref: uniprot Q9Z286 422
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P04897 110
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P59215 150
organism: Rattus norvegicus

uniprot Q7PPI8 385
type: UnificationXref
id: Q7PPI8
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RGI5 43
organism: Canis lupus familiaris

uniprot P18851 122
type: UnificationXref
id: P18851
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P04899 111
xref: PTHR10218:SF73
organism: Homo sapiens

uniprot Q7Q6E0 204
type: UnificationXref
id: Q7Q6E0
db: uniprot

PARTICIPANT STOICHIOMETRY r55 449
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

uniprot P54313 148
type: UnificationXref
id: P54313
db: uniprot

uniprot A0A3Q1NGS8 17
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

G protein alpha o subunit
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P16378 117
organism: Drosophila melanogaster

uniprot Q6PBY0 195
type: UnificationXref
id: Q6PBY0
db: uniprot

Synaptobrevin
type: ProteinReference
xref: uniprot P18489 269
xref: PTHR45701:SF10
organism: Drosophila melanogaster

uniprot G2HIJ9 255
type: UnificationXref
id: G2HIJ9
db: uniprot

SNARE Complex s13 sa12 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

TRANSPORT
type: RelationshipTypeVocabulary

SNAP25 homologous protein SNAP29
type: ProteinReference
xref: uniprot Q9SD96 314
xref: PTHR19305:SF24
organism: Arabidopsis thaliana

uniprot P12368 355
type: UnificationXref
id: P12368
db: uniprot

uniprot Q3ZCA7 180
type: UnificationXref
id: Q3ZCA7
db: uniprot

uniprot P20353 126
type: UnificationXref
id: P20353
db: uniprot

PARTICIPANT STOICHIOMETRY r55 450
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 23

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P17343 120
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: uniprot P18872 124
xref: PTHR10218:SF302
organism: Mus musculus

PTHR24353:SF133
type: RelationshipXref
id: PTHR24353:SF133
db: PANTHER Family
relationship type: By Homology

uniprot P31422 231
type: UnificationXref
id: P31422
db: uniprot

uniprot P63078 162
type: UnificationXref
id: P63078
db: uniprot

PTHR24353:SF137
type: RelationshipXref
id: PTHR24353:SF137
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF135
type: RelationshipXref
id: PTHR24353:SF135
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3SZ98 179
organism: Bos taurus

Synaptosomal-associated protein 25-A
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q5TZ66 303
organism: Danio rerio

uniprot O14775 107
type: UnificationXref
id: O14775
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A5PEW5 240
xref: PTHR19305:SF14
organism: Caenorhabditis elegans

uniprot O00161 262
type: UnificationXref
id: O00161
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 30

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q1D9 97
organism: Pan troglodytes

uniprot P13861 359
type: UnificationXref
id: P13861
db: uniprot

GNAI2 protein
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot A7MBH9 24
organism: Bos taurus

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P52287 146
organism: Rattus norvegicus

uniprot F6T0T9 332
type: UnificationXref
id: F6T0T9
db: uniprot

uniprot P81900 375
type: UnificationXref
id: P81900
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot F6UBJ8 246
organism: Xenopus tropicalis

uniprot A3KMS9 321
type: UnificationXref
id: A3KMS9
db: uniprot

uniprot P62874 157
type: UnificationXref
id: P62874
db: uniprot

uniprot P09471 115
type: UnificationXref
id: P09471
db: uniprot

brain-derived neurotrophic factor
type: DnaRegionReference
member entity reference: Brain-derived neurotrophic factor
member entity reference: Brain-derived neurotrophic factor (Fragment)
xref: G01540
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group II pathway.GENE.GENE.BDNF
comment: ENTITY_REFERENCE_NOTES= Long Name: brain-derived neurotrophic factor Synonym: Synonym not specified Accession: G01540
display name: BDNF

uniprot Q6TNT8 198
type: UnificationXref
id: Q6TNT8
db: uniprot

Syntaxin-1A
type: ProteinReference
xref: PTHR19957:SF84
xref: uniprot P32851 272
organism: Rattus norvegicus

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot P00514 346
organism: Bos taurus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P00515 347
organism: Bos taurus

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P00517 348
organism: Bos taurus

PTHR24353:SF128
type: RelationshipXref
id: PTHR24353:SF128
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9615 38
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot O02495 263
type: UnificationXref
id: O02495
db: uniprot

uniprot P63219 170
type: UnificationXref
id: P63219
db: uniprot

uniprot H2R1G3 340
type: UnificationXref
id: H2R1G3
db: uniprot

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r57
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 468
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 469
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

uniprot Q61290 415
type: UnificationXref
id: Q61290
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 60

uniprot Q7T3D3 206
type: UnificationXref
id: Q7T3D3
db: uniprot

Brain-derived neurotrophic factor
type: DnaReference
xref: PTHR11589:SF3
organism: Gallus gallus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7AE17 104
organism: Pan troglodytes

uniprot F7FXA9 86
type: UnificationXref
id: F7FXA9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 35
organism: Gallus gallus

uniprot Q7Q6D2 201
type: UnificationXref
id: Q7Q6D2
db: uniprot

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 211

ncbitaxon 7668 266
type: UnificationXref
id: 7668
db: ncbitaxon

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P05987 351
organism: Dictyostelium discoideum

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: PTHR45628:SF6
xref: uniprot O55017 407
organism: Mus musculus

Synaptosomal-associated protein 23
type: ProteinReference
xref: uniprot O00161 262
xref: PTHR19305:SF4
organism: Homo sapiens

uniprot P18872 124
type: UnificationXref
id: P18872
db: uniprot

G protein subunit alpha transducin 2
type: ProteinReference
xref: uniprot F6W0P2 68
xref: PTHR10218:SF68
organism: Monodelphis domestica

PTHR24353:SF117
type: RelationshipXref
id: PTHR24353:SF117
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF116
type: RelationshipXref
id: PTHR24353:SF116
db: PANTHER Family
relationship type: By Homology

uniprot Q9ERB0 310
type: UnificationXref
id: Q9ERB0
db: uniprot

PKA
type: Protein
entity reference: PKA
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot A3KMS9 321
organism: Danio rerio

uniprot Q6PBN9 193
type: UnificationXref
id: Q6PBN9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot H2RI77 343
xref: PTHR24353:SF128
organism: Pan troglodytes

TRANSCRIPTION
type: InteractionVocabulary

uniprot A8XW88 322
type: UnificationXref
id: A8XW88
db: uniprot

uniprot Q9HAV0 217
type: UnificationXref
id: Q9HAV0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 87
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot B2RSH2 26
organism: Mus musculus

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 448
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F6V5G0 225
type: UnificationXref
id: F6V5G0
db: uniprot

uniprot Q92356 308
type: UnificationXref
id: Q92356
db: uniprot

Vesicle associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot F1PRG8 244
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P08752 112
organism: Mus musculus

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot P08754 114
xref: PTHR10218:SF230
organism: Homo sapiens

AGAP004940-PA
type: ProteinReference
xref: PTHR11635:SF162
xref: uniprot Q7PPI8 385
organism: Anopheles gambiae

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot P08753 113
xref: PTHR10218:SF230
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(K) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot F6VL43 67
organism: Macaca mulatta

uniprot P61264 279
type: UnificationXref
id: P61264
db: uniprot

uniprot Q14BI2 234
type: UnificationXref
id: Q14BI2
db: uniprot

uniprot K7E376 105
type: UnificationXref
id: K7E376
db: uniprot

uniprot P07278 352
type: UnificationXref
id: P07278
db: uniprot

uniprot F6Y3N2 72
type: UnificationXref
id: F6Y3N2
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9ERB0 310
organism: Mus musculus

uniprot P36600 371
type: UnificationXref
id: P36600
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P05132 350
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P05131 349
organism: Bos taurus

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: PTHR11824:SF17
xref: uniprot Q8R3Z5 416
organism: Mus musculus

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 390

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 217
organism: Homo sapiens

Syntaxin-1A
type: ProteinReference
xref: uniprot O35526 264
xref: PTHR19957:SF84
organism: Mus musculus

uniprot P22612 363
type: UnificationXref
id: P22612
db: uniprot

uniprot P60878 276
type: UnificationXref
id: P60878
db: uniprot

uniprot P23763 270
type: UnificationXref
id: P23763
db: uniprot

GDP s12 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot Q10282 172
organism: Schizosaccharomyces pombe

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P38400 136
organism: Canis lupus familiaris

uniprot F7EBE7 81
type: UnificationXref
id: F7EBE7
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RJB3 45
organism: Canis lupus familiaris

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 139

uniprot P43425 137
type: UnificationXref
id: P43425
db: uniprot

uniprot Q90WX5 212
type: UnificationXref
id: Q90WX5
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P18851 122
organism: Saccharomyces cerevisiae

uniprot F7GI54 89
type: UnificationXref
id: F7GI54
db: uniprot

Guanine nucleotide-binding protein subunit beta-5b
type: ProteinReference
xref: uniprot Q6PBY0 195
organism: Danio rerio

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot E2RRA1 323
xref: PTHR11635:SF156
organism: Canis lupus familiaris

G-protein
type: ProteinReference
xref: P01047
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group II pathway.PROTEIN.GENERIC.G-protein
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: GNAI2 protein
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-2
member entity reference: Guanine nucleotide-binding protein subunit beta-1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
member entity reference: G protein subunit alpha i3
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
member entity reference: G protein subunit beta 1
member entity reference: Uncharacterized protein
member entity reference: G protein alpha i subunit
member entity reference: AGAP001506-PA
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: G protein subunit beta 2
member entity reference: Guanine nucleotide binding protein, beta subunit
member entity reference: Guanine nucleotide-binding protein subunit beta-2
member entity reference: Guanine nucleotide-binding protein alpha-3 subunit
member entity reference: GNB4 protein
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
member entity reference: Guanine nucleotide-binding protein subunit gamma-1
member entity reference: Guanine nucleotide-binding protein G(t) subunit alpha-2
member entity reference: Guanine nucleotide-binding protein (G protein), alpha transducing activity polypeptide 2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: Gi alpha subunit
member entity reference: Guanine nucleotide-binding protein beta subunit
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
member entity reference: Guanine nucleotide-binding protein G(k) subunit alpha
member entity reference: G protein subunit gamma 5
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: AGAP010589-PA
member entity reference: Guanine nucleotide-binding protein G(O) subunit alpha isoform a
member entity reference: Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
member entity reference: Guanine nucleotide-binding protein alpha-2 subunit
member entity reference: THO complex subunit, putative
member entity reference: G protein subunit beta 4
member entity reference: Guanine nucleotide-binding protein alpha-4 subunit
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
member entity reference: G protein subunit alpha transducin 2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

uniprot P36975 274
type: UnificationXref
id: P36975
db: uniprot

uniprot P04897 110
type: UnificationXref
id: P04897
db: uniprot

Gbeta5
type: ProteinReference
xref: uniprot Q9W3J1 219
organism: Drosophila melanogaster

uniprot Q6P025 191
type: UnificationXref
id: Q6P025
db: uniprot

PTHR45701:SF6
type: RelationshipXref
id: PTHR45701:SF6
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF7
type: RelationshipXref
id: PTHR45701:SF7
db: PANTHER Family
relationship type: By Homology

G protein subunit gamma 5
type: ProteinReference
xref: uniprot H2PZA6 94
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1PJE5 54
organism: Canis lupus familiaris

uniprot E2RHY4 44
type: UnificationXref
id: E2RHY4
db: uniprot

PTHR45701:SF5
type: RelationshipXref
id: PTHR45701:SF5
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF3
type: RelationshipXref
id: PTHR45701:SF3
db: PANTHER Family
relationship type: By Homology

uniprot F7G7I9 88
type: UnificationXref
id: F7G7I9
db: uniprot

PTHR45701:SF1
type: RelationshipXref
id: PTHR45701:SF1
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot Q9UK08 218
organism: Homo sapiens

uniprot P60877 275
type: UnificationXref
id: P60877
db: uniprot

uniprot P31421 230
type: UnificationXref
id: P31421
db: uniprot

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: PTHR45628:SF6
xref: uniprot Q00975 410
organism: Homo sapiens

uniprot Q9S7P9 313
type: UnificationXref
id: Q9S7P9
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 12

uniprot Q7PXF7 386
type: UnificationXref
id: Q7PXF7
db: uniprot

uniprot F1N1E0 402
type: UnificationXref
id: F1N1E0
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot Q8MJ44 391
organism: Canis lupus familiaris

uniprot Q5ZM91 382
type: UnificationXref
id: Q5ZM91
db: uniprot

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: uniprot P13861 359
xref: PTHR11635:SF153
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot E9GNI4 327
xref: PTHR24353:SF117
organism: Daphnia pulex

uniprot Q5BJ11 181
type: UnificationXref
id: Q5BJ11
db: uniprot

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 16
organism: Pan troglodytes

uniprot Q9N0Y0 312
type: UnificationXref
id: Q9N0Y0
db: uniprot

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q17QQ3 294
xref: PTHR19305:SF5
organism: Bos taurus

uniprot E2RBE7 42
type: UnificationXref
id: E2RBE7
db: uniprot

Syntaxin 1B
type: ProteinReference
xref: PTHR19957:SF334
xref: uniprot F6WJB1 248
organism: Monodelphis domestica

uniprot P60880 278
type: UnificationXref
id: P60880
db: uniprot

uniprot H2PZK9 95
type: UnificationXref
id: H2PZK9
db: uniprot

uniprot A0A3Q1LZY8 400
type: UnificationXref
id: A0A3Q1LZY8
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot Q9N0Y0 312
xref: PTHR45701:SF5
organism: Macaca mulatta

uniprot F1PJE5 54
type: UnificationXref
id: F1PJE5
db: uniprot

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P36975 274
xref: PTHR19305:SF14
organism: Drosophila melanogaster

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q3T0Y8 299
xref: PTHR45701:SF7
organism: Bos taurus

Ca2+
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=ION

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 73
organism: Monodelphis domestica

PTHR10037:SF290
type: RelationshipXref
id: PTHR10037:SF290
db: PANTHER Family
relationship type: By Homology

uniprot Q61016 187
type: UnificationXref
id: Q61016
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: uniprot Q15836 292
xref: PTHR45701:SF6
organism: Homo sapiens

uniprot E9FUX0 46
type: UnificationXref
id: E9FUX0
db: uniprot

Brain-derived neurotrophic factor
type: DnaReference
xref: PTHR11589:SF3
organism: Homo sapiens

uniprot E1BUE5 224
type: UnificationXref
id: E1BUE5
db: uniprot

uniprot Q6NW93 384
type: UnificationXref
id: Q6NW93
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot P63097 164
xref: PTHR10218:SF227
organism: Bos taurus

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P63096 163
organism: Homo sapiens

uniprot F7CXD0 79
type: UnificationXref
id: F7CXD0
db: uniprot

Synaptosomal-associated protein 25-B
type: ProteinReference
xref: uniprot Q6PC54 306
xref: PTHR19305:SF5
organism: Danio rerio

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot O44419 265
organism: Strongylocentrotus purpuratus

uniprot P27791 365
type: UnificationXref
id: P27791
db: uniprot

uniprot Q62442 304
type: UnificationXref
id: Q62442
db: uniprot

Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
type: ProteinReference
xref: uniprot Q6DH55 190
organism: Danio rerio

uniprot P63097 164
type: UnificationXref
id: P63097
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6TFY2 62
organism: Macaca mulatta

uniprot P22454 127
type: UnificationXref
id: P22454
db: uniprot

uniprot H2Q9G5 99
type: UnificationXref
id: H2Q9G5
db: uniprot

uniprot B7Q3T6 27
type: UnificationXref
id: B7Q3T6
db: uniprot

uniprot F7G3J2 87
type: UnificationXref
id: F7G3J2
db: uniprot

Complex (mGluR2/3/ Glutamate/G-protein/ GDP)
type: Complex
component stoichiometry: mGluR2 3 s9 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: G protein s11 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glutamate s10 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s12 sa11 STOICHIOMETRY ID COMPLEX
component: Glutamate
component: mGluR2/3
component: GDP
component: G-protein
feature: COMPLEX BINDING FEATURE s80 a94 439
feature: COMPLEX BINDING FEATURE s80 a94 433
feature: COMPLEX BINDING FEATURE s80 a94 437
feature: COMPLEX BINDING FEATURE s80 a94 435
cellular location: axon terminus

uniprot P50150 142
type: UnificationXref
id: P50150
db: uniprot

uniprot F7H091 227
type: UnificationXref
id: F7H091
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q62442 304
organism: Mus musculus

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 33

uniprot E9GNI4 327
type: UnificationXref
id: E9GNI4
db: uniprot

PTHR10037:SF289
type: RelationshipXref
id: PTHR10037:SF289
db: PANTHER Family
relationship type: By Homology

uniprot Q9Z2P6 318
type: UnificationXref
id: Q9Z2P6
db: uniprot

uniprot Q7ZW82 207
type: UnificationXref
id: Q7ZW82
db: uniprot

uniprot Q8R3Z5 416
type: UnificationXref
id: Q8R3Z5
db: uniprot

uniprot F1NLV4 52
type: UnificationXref
id: F1NLV4
db: uniprot

ncbitaxon 9913 13
type: UnificationXref
id: 9913
db: ncbitaxon

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 47

INHIBITION
type: RelationshipTypeVocabulary

Brain-derived neurotrophic factor
type: DnaReference
xref: PTHR11589:SF3
organism: Mus musculus

uniprot H2R3M7 341
type: UnificationXref
id: H2R3M7
db: uniprot

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot Q9DBC7 395
xref: PTHR11635:SF129
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63078 162
organism: Mus musculus

ncbitaxon 189518 390
type: UnificationXref
id: 189518
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 161
organism: Rattus norvegicus

uniprot F6ZIZ9 74
type: UnificationXref
id: F6ZIZ9
db: uniprot

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P09471 115
organism: Homo sapiens

TRANSPORT_LEFT__Glutamate-RIGHT__Glutamate-_r52
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 460
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 459
left: Glutamate
interaction type: TRANSPORT
right: Glutamate

AC
type: ProteinReference
xref: P01052
standard name: adenylate cyclase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group II pathway.PROTEIN.GENERIC.AC
comment: ENTITY_REFERENCE_NOTES= Long Name: Adenylate Cyclase Synonym: AC Accession: P01052
member entity reference: Uncharacterized protein
member entity reference: Adenylate cyclase type 10

LD03592p
type: ProteinReference
xref: uniprot Q9W1I8 316
xref: PTHR19305:SF9
organism: Drosophila melanogaster

Syntaxin 1A
type: ProteinReference
xref: uniprot F1PVP1 245
xref: PTHR19957:SF84
organism: Canis lupus familiaris

uniprot Q7Q3T7 387
type: UnificationXref
id: Q7Q3T7
db: uniprot

uniprot F6XHP0 70
type: UnificationXref
id: F6XHP0
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 148
organism: Rattus norvegicus

uniprot F6YZA3 73
type: UnificationXref
id: F6YZA3
db: uniprot

uniprot G5EEN8 256
type: UnificationXref
id: G5EEN8
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 147
organism: Rattus norvegicus

Putative SNAP25 homologous protein SNAP30
type: ProteinReference
xref: uniprot Q9LMG8 311
xref: PTHR19305:SF25
organism: Arabidopsis thaliana

Complex (mGluR2/3/ Glutamate)
type: Complex
component stoichiometry: mGluR2 3 s1 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glutamate s2 sa2 STOICHIOMETRY ID COMPLEX
component: Glutamate
component: mGluR2/3
feature: COMPLEX BINDING FEATURE s35 a37 445
feature: COMPLEX BINDING FEATURE s35 a37 447
feature: ACTIVE 319
cellular location: axon terminus

ncbitaxon 7739 30
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot F6WX39 69
type: UnificationXref
id: F6WX39
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 80
organism: Ornithorhynchus anatinus

uniprot H2QFK0 338
type: UnificationXref
id: H2QFK0
db: uniprot

uniprot E2RGI5 43
type: UnificationXref
id: E2RGI5
db: uniprot

uniprot P05132 350
type: UnificationXref
id: P05132
db: uniprot

uniprot Q14416 232
type: UnificationXref
id: Q14416
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q0V7N0 290
organism: Bos taurus

uniprot E2R2S3 37
type: UnificationXref
id: E2R2S3
db: uniprot

uniprot P38040 135
type: UnificationXref
id: P38040
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 196
organism: Danio rerio

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot Q7T3D3 206
organism: Danio rerio

uniprot P62871 154
type: UnificationXref
id: P62871
db: uniprot

PARTICIPANT STOICHIOMETRY r31 466
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r31 467
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

G protein s8 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-protein
stoichiometric coefficient: 1.0

uniprot P63216 167
type: UnificationXref
id: P63216
db: uniprot

uniprot P16520 119
type: UnificationXref
id: P16520
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 50

Voltage-dependent R-type calcium channel subunit alpha-1E
type: ProteinReference
xref: PTHR45628:SF5
xref: uniprot Q61290 415
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VKI4 66
xref: PTHR10218:SF68
organism: Macaca mulatta

ncbitaxon 9544 63
type: UnificationXref
id: 9544
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot A0A1D5QIS2 237
organism: Macaca mulatta

uniprot P31324 369
type: UnificationXref
id: P31324
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_r55
controller: Complex (GTP/G-protein)

uniprot P30625 366
type: UnificationXref
id: P30625
db: uniprot

Metabotropic glutamate receptor 2 isoform a
type: ProteinReference
xref: uniprot F7H091 227
xref: PTHR24060:SF147
organism: Macaca mulatta

uniprot Q9LMG8 311
type: UnificationXref
id: Q9LMG8
db: uniprot

uniprot E2R4I7 40
type: UnificationXref
id: E2R4I7
db: uniprot

uniprot E1BAB4 223
type: UnificationXref
id: E1BAB4
db: uniprot

PTHR19957:SF41
type: RelationshipXref
id: PTHR19957:SF41
db: PANTHER Family
relationship type: By Homology

uniprot H2RER5 342
type: UnificationXref
id: H2RER5
db: uniprot

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot P34099 370
xref: PTHR24353:SF37
organism: Dictyostelium discoideum

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r56
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 470
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 471
left: Ca2+
interaction type: STATE_TRANSITION
right: Ca2+

Voltage-dependent R-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR45628:SF5
xref: uniprot A0A1D5Q7C3 397
organism: Macaca mulatta

uniprot Q6DGZ5 189
type: UnificationXref
id: Q6DGZ5
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot H2Q995 257
xref: PTHR19305:SF4
organism: Pan troglodytes

cAMP-dependent protein kinase catalytic subunit 3
type: ProteinReference
xref: uniprot P16912 361
xref: PTHR24353:SF37
organism: Drosophila melanogaster

Guanine nucleotide-binding protein (G protein), beta 5
type: ProteinReference
xref: uniprot F7EBE7 81
organism: Xenopus tropicalis

uniprot Q00975 410
type: UnificationXref
id: Q00975
db: uniprot

mGluR2/3
type: Protein
entity reference: mGluR2/3
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 428
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot Q10282 172
type: UnificationXref
id: Q10282
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P16520 119
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6V461 65
organism: Ornithorhynchus anatinus

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 301

cAMP-dependent protein kinase type I regulatory subunit
type: ProteinReference
xref: uniprot P16905 360
xref: PTHR11635:SF152
organism: Drosophila melanogaster

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6PBR4 194
organism: Danio rerio

Protein kinase, cAMP-dependent, catalytic, beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot Q3ZB92 379
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DGZ5 189
organism: Danio rerio

uniprot Q7ZUC1 307
type: UnificationXref
id: Q7ZUC1
db: uniprot

uniprot A5PKD6 21
type: UnificationXref
id: A5PKD6
db: uniprot

Protein kinase A catalytic subunit isoform 1
type: ProteinReference
xref: PTHR24353:SF67
xref: uniprot Q9GNR4 396
organism: Leishmania major

uniprot H2Q3W7 98
type: UnificationXref
id: H2Q3W7
db: uniprot

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot A0A2I3SR99 239
xref: PTHR45701:SF7
organism: Pan troglodytes

uniprot E2QUL2 243
type: UnificationXref
id: E2QUL2
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A0A1D5QYR9 238
xref: PTHR19305:SF4
organism: Macaca mulatta

uniprot K7AEL3 345
type: UnificationXref
id: K7AEL3
db: uniprot

uniprot Q3SZ98 179
type: UnificationXref
id: Q3SZ98
db: uniprot

Metabotropic glutamate receptor 3
type: ProteinReference
xref: PTHR24060:SF160
xref: uniprot Q9QYS2 235
organism: Mus musculus

Gi alpha subunit
type: ProteinReference
xref: uniprot C3XY80 29
xref: PTHR10218:SF310
organism: Branchiostoma floridae

PARTICIPANT STOICHIOMETRY r58 463
type: Stoichiometry
physical entity: SNARE Complex
stoichiometric coefficient: 1.0

uniprot F7CTP1 78
type: UnificationXref
id: F7CTP1
db: uniprot

PARTICIPANT STOICHIOMETRY r58 464
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 465
type: Stoichiometry
physical entity: Complex (SNARE Complex/Ca2+)
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot F7FXA9 86
organism: Macaca mulatta

uniprot F1PRG8 244
type: UnificationXref
id: F1PRG8
db: uniprot

PKA
type: Protein
entity reference: PKA
feature: ACTIVE 319
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

PTHR11589:SF3
type: RelationshipXref
id: PTHR11589:SF3
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2b
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot X1WDQ5 221
organism: Danio rerio

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot P29387 130
organism: Mus musculus

uniprot A0A1D5QEM1 236
type: UnificationXref
id: A0A1D5QEM1
db: uniprot

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 181
organism: Danio rerio

Syntaxin-1A
type: ProteinReference
xref: PTHR19957:SF41
xref: uniprot Q24547 296
organism: Drosophila melanogaster

ncbitaxon 9031 10
type: UnificationXref
id: 9031
db: ncbitaxon

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 123

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 118

uniprot P12370 357
type: UnificationXref
id: P12370
db: uniprot

uniprot Q9W1I8 316
type: UnificationXref
id: Q9W1I8
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 186
organism: Mus musculus

uniprot P50154 145
type: UnificationXref
id: P50154
db: uniprot

PTHR11824:SF17
type: RelationshipXref
id: PTHR11824:SF17
db: PANTHER Family
relationship type: By Homology

uniprot F1MYW8 51
type: UnificationXref
id: F1MYW8
db: uniprot

uniprot F7ES96 83
type: UnificationXref
id: F7ES96
db: uniprot

PTHR10218:SF215
type: RelationshipXref
id: PTHR10218:SF215
db: PANTHER Family
relationship type: By Homology

uniprot Q9SD96 314
type: UnificationXref
id: Q9SD96
db: uniprot

uniprot F7G4Q0 335
type: UnificationXref
id: F7G4Q0
db: uniprot

G-protein
type: Protein
entity reference: G-protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa4 430
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

AGAP001506-PA
type: ProteinReference
xref: uniprot Q7PXP3 199
organism: Anopheles gambiae

uniprot P12369 356
type: UnificationXref
id: P12369
db: uniprot

Brain-derived neurotrophic factor (Fragment)
type: DnaReference
xref: PTHR11589:SF3
organism: Ornithorhynchus anatinus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_r31
controller: AC

uniprot E2RRA1 323
type: UnificationXref
id: E2RRA1
db: uniprot

ncbitaxon 7227 118
type: UnificationXref
id: 7227
db: ncbitaxon

PTHR10218:SF227
type: RelationshipXref
id: PTHR10218:SF227
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 187
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot Q61017 188
organism: Mus musculus

ACTIVE 319
type: EntityFeature
comment: Active state

uniprot H2Q0J3 419
type: UnificationXref
id: H2Q0J3
db: uniprot

Adenylate cyclase type 10
type: ProteinReference
xref: uniprot Q96PN6 421
xref: PTHR16305:SF28
organism: Homo sapiens

ncbitaxon 5664 326
type: UnificationXref
id: 5664
db: ncbitaxon

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot Q9Z2P6 318
xref: PTHR19305:SF9
organism: Rattus norvegicus

CAP family transcription factor
type: ProteinReference
xref: uniprot Q8CXT1 389
xref: PTHR11635:SF157
organism: Leptospira interrogans

uniprot Q9QYS2 235
type: UnificationXref
id: Q9QYS2
db: uniprot

uniprot Q9BIG5 214
type: UnificationXref
id: Q9BIG5
db: uniprot

uniprot Q20636 176
type: UnificationXref
id: Q20636
db: uniprot

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q9WUF4 317
xref: PTHR45701:SF7
organism: Rattus norvegicus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q5R1X1 302
xref: PTHR19305:SF5
organism: Pan troglodytes

SNARE Complex
type: ProteinReference
xref: P01049
standard name: N-ethylmaleimide-sensitive factor attachment protein receptor
comment: ENTITY_REFERENCE_NOTES= Long Name: N-ethylmaleimide-sensitive factor attachment protein receptor Synonym: SNARE Accession: P01049
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group II pathway.PROTEIN.GENERIC.SNARE Complex
member entity reference: Synaptosomal-associated protein
member entity reference: Putative synaptobrevin homologue SNC1/2 (Eurofung)
member entity reference: Vesicle-associated membrane protein 1
member entity reference: Syntaxin-1A isoform 1
member entity reference: Syntaxin 1B
member entity reference: Synaptosomal-associated protein 29
member entity reference: Vesicle-associated membrane protein 8
member entity reference: Syntaxin-1A
member entity reference: Syntaxin-1B
member entity reference: VAMP3 isoform 1
member entity reference: Vesicle-associated membrane protein 2
member entity reference: t-SNARE protein aex-4
member entity reference: Neuronal synaptobrevin, isoform J
member entity reference: SNAP25 homologous protein SNAP33
member entity reference: Vesicle associated membrane protein 8
member entity reference: Synaptosomal-associated protein 25
member entity reference: Soluble NSF attachment protein 29
member entity reference: Synaptobrevin-1
member entity reference: Uncharacterized protein
member entity reference: Vesicle-associated membrane protein 3
member entity reference: Synaptobrevin
member entity reference: SNAP25 homologous protein SNAP29
member entity reference: Synaptosomal-associated protein 25-A
member entity reference: SNAP29 isoform 1
member entity reference: Putative SNAP25 homologous protein SNAP30
member entity reference: LD03592p
member entity reference: Synaptosomal-associated protein 23
member entity reference: Syntaxin 1A
member entity reference: Vesicle associated membrane protein 1
member entity reference: Synaptosomal-associated protein 25-B
member entity reference: STX1A isoform 3
member entity reference: Synaptobrevin homolog 1

ncbitaxon 9598 11
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot Q6DBV8 383
type: UnificationXref
id: Q6DBV8
db: uniprot

Syntaxin 1B
type: ProteinReference
xref: PTHR19957:SF334
xref: uniprot Q1MTI1 295
organism: Danio rerio

synaptic vesicle
type: CellularLocationVocabulary
xref: GO GO:0008021 2

PTHR10218:SF230
type: RelationshipXref
id: PTHR10218:SF230
db: PANTHER Family
relationship type: By Homology

Voltage-dependent P/Q-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot F1N1E0 402
xref: PTHR10037:SF290
organism: Bos taurus

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot P10644 353
xref: PTHR11635:SF129
organism: Homo sapiens

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 20

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF26
xref: uniprot Q6PBN9 193
organism: Danio rerio

PKA
type: ProteinReference
xref: P01050
standard name: Protein kinase A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group II pathway.PROTEIN.GENERIC.PKA
comment: ENTITY_REFERENCE_NOTES= Long Name: Protein Kinase A Synonym: PKA Accession: P01050
member entity reference: Uncharacterized protein
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit beta
member entity reference: CAP family transcription factor
member entity reference: Protein kinase A catalytic subunit
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta a
member entity reference: cAMP-dependent protein kinase regulatory subunit
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta
member entity reference: cAMP-dependent protein kinase catalytic subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit beta
member entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit
member entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha isoform 1
member entity reference: cAMP-dependent protein kinase catalytic subunit gamma
member entity reference: AGAP001384-PA
member entity reference: AGAP004940-PA
member entity reference: Protein kinase cAMP-activated catalytic subunit alpha
member entity reference: Protein kinase, cAMP-dependent, regulatory, type II, alpha, B
member entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit 1
member entity reference: PRKAR2A isoform 1
member entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit alpha
member entity reference: Prkar1a protein
member entity reference: cAMP-dependent protein kinase catalytic subunit 3
member entity reference: cAMP-dependent protein kinase type II regulatory subunit
member entity reference: Protein kinase A catalytic subunit isoform 2
member entity reference: cAMP-dependent protein kinase type I regulatory subunit
member entity reference: cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B
member entity reference: PRKACB isoform 3
member entity reference: Protein kinase, X-linked
member entity reference: cGMP-dependent 3',5'-cGMP phosphodiesterase A
member entity reference: cAMP-dependent protein kinase catalytic subunit PRKX
member entity reference: Protein kinase cAMP-activated catalytic subunit beta
member entity reference: AGAP008039-PA (Fragment)
member entity reference: Protein kinase cAMP-dependent type I regulatory subunit alpha
member entity reference: PRKAR1A isoform 12
member entity reference: cAMP-dependent protein kinase catalytic subunit beta isoform 1
member entity reference: Protein kinase A catalytic subunit isoform 1
member entity reference: Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
member entity reference: PRKACG isoform 1
member entity reference: Protein kinase, cAMP-dependent, regulatory, type I, beta

uniprot F6PGC8 58
type: UnificationXref
id: F6PGC8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24060:SF160
xref: uniprot E1BUE5 224
organism: Gallus gallus

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q922R0 394
organism: Mus musculus

uniprot H2RCB8 260
type: UnificationXref
id: H2RCB8
db: uniprot

TRIGGER
type: RelationshipTypeVocabulary

uniprot G3V8K2 93
type: UnificationXref
id: G3V8K2
db: uniprot

uniprot F6W0P2 68
type: UnificationXref
id: F6W0P2
db: uniprot

uniprot H2QMN4 100
type: UnificationXref
id: H2QMN4
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot O14610 106
organism: Homo sapiens

uniprot P97445 409
type: UnificationXref
id: P97445
db: uniprot

GRM3 isoform 1
type: ProteinReference
xref: PTHR24060:SF160
xref: uniprot H2QUV3 228
organism: Pan troglodytes

ncbitaxon 559292 123
type: UnificationXref
id: 559292
db: ncbitaxon

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P49177 138
organism: Arabidopsis thaliana

uniprot P00514 346
type: UnificationXref
id: P00514
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r57
control type: ACTIVATION
controller: Ca2+

uniprot Q3KRE3 178
type: UnificationXref
id: Q3KRE3
db: uniprot

PTHR10218:SF245
type: RelationshipXref
id: PTHR10218:SF245
db: PANTHER Family
relationship type: By Homology

uniprot P63096 163
type: UnificationXref
id: P63096
db: uniprot

uniprot A0A2I3SR99 239
type: UnificationXref
id: A0A2I3SR99
db: uniprot

uniprot Q9GNR4 396
type: UnificationXref
id: Q9GNR4
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: uniprot P30625 366
xref: PTHR11635:SF152
organism: Caenorhabditis elegans

STATE_TRANSITION_LEFT__AC-RIGHT__AC-_r55
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 450
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 449
left: AC
interaction type: STATE_TRANSITION
right: AC

uniprot F5HKU8 403
type: UnificationXref
id: F5HKU8
db: uniprot

uniprot Q6PH57 196
type: UnificationXref
id: Q6PH57
db: uniprot

uniprot F7DNS6 253
type: UnificationXref
id: F7DNS6
db: uniprot

uniprot F8W3G9 92
type: UnificationXref
id: F8W3G9
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 116
organism: Bos taurus

uniprot X1WDQ5 221
type: UnificationXref
id: X1WDQ5
db: uniprot

BDNF
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Glutamate
type: SmallMolecule
cellular location: synaptic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

AC
type: Protein
entity reference: AC
feature: ACTIVE 319
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Cone transducin alpha subunit
type: ProteinReference
xref: PTHR10218:SF68
xref: uniprot Q90WX5 212
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot F7H6T2 336
organism: Macaca mulatta

Voltage-dependent R-type calcium channel subunit alpha-1E
type: ProteinReference
xref: uniprot Q15878 414
xref: PTHR45628:SF5
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T7 91
organism: Macaca mulatta

uniprot F6TFY2 62
type: UnificationXref
id: F6TFY2
db: uniprot

uniprot Q16623 293
type: UnificationXref
id: Q16623
db: uniprot

uniprot Q5I080 183
type: UnificationXref
id: Q5I080
db: uniprot

uniprot K7AE17 104
type: UnificationXref
id: K7AE17
db: uniprot

Protein kinase, cAMP-dependent, regulatory, type II, alpha, B
type: ProteinReference
xref: uniprot Q6NW93 384
xref: PTHR11635:SF153
organism: Danio rerio

uniprot F7HAK5 337
type: UnificationXref
id: F7HAK5
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QUY0 102
organism: Pan troglodytes

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot E2QUL2 243
xref: PTHR45701:SF7
organism: Canis lupus familiaris

uniprot P63214 165
type: UnificationXref
id: P63214
db: uniprot

uniprot P61954 153
type: UnificationXref
id: P61954
db: uniprot

uniprot P17612 362
type: UnificationXref
id: P17612
db: uniprot

Protein CBR-UNC-2 (Fragment)
type: ProteinReference
xref: PTHR45628:SF7
xref: uniprot A8WRW6 401
organism: Caenorhabditis briggsae

Guanine nucleotide-binding protein G(O) subunit alpha isoform a
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot F7GQC5 90
organism: Macaca mulatta

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot F5HH30 56
organism: Neurospora crassa

Protein kinase, X-linked
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q5BK52 380
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P43425 137
organism: Rattus norvegicus

uniprot F6R7N8 331
type: UnificationXref
id: F6R7N8
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IGZ2 19
organism: Xenopus tropicalis

uniprot D4AA42 34
type: UnificationXref
id: D4AA42
db: uniprot

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot Q5ZM91 382
organism: Gallus gallus

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: PTHR11824:SF17
xref: uniprot Q9MZL7 417
organism: Bos taurus

uniprot P54406 149
type: UnificationXref
id: P54406
db: uniprot

Ca2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

uniprot F6UJE8 64
type: UnificationXref
id: F6UJE8
db: uniprot

uniprot Q28HP6 297
type: UnificationXref
id: Q28HP6
db: uniprot

uniprot P16378 117
type: UnificationXref
id: P16378
db: uniprot

uniprot P34099 370
type: UnificationXref
id: P34099
db: uniprot

Protein kinase, cAMP-dependent, regulatory, type I, beta
type: ProteinReference
xref: uniprot Q08C49 377
xref: PTHR11635:SF126
organism: Danio rerio

uniprot Q5I0F6 381
type: UnificationXref
id: Q5I0F6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XWE8 71
organism: Monodelphis domestica

ncbitaxon 367110 57
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot Q01386 376
type: UnificationXref
id: Q01386
db: uniprot

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__BDNF-RIGHT__BDNF-_re12
control type: INHIBITION
controller: PKA

uniprot P31321 367
type: UnificationXref
id: P31321
db: uniprot

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot Q92356 308
organism: Schizosaccharomyces pombe

uniprot Q15KE4 174
type: UnificationXref
id: Q15KE4
db: uniprot

AGAP005904-PA
type: ProteinReference
xref: uniprot Q7Q6E0 204
xref: PTHR10218:SF310
organism: Anopheles gambiae

SNARE Complex
type: Protein
entity reference: SNARE Complex
feature: SNARE Complex s13 sa12 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa12 442
feature: ACTIVE 319
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot O14610 106
type: UnificationXref
id: O14610
db: uniprot

AGAP005911-PA
type: ProteinReference
xref: uniprot Q7Q6D4 203
organism: Anopheles gambiae

Voltage-dependent R-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR45628:SF5
xref: uniprot A0A2J8N6N1 399
organism: Pan troglodytes

uniprot Q5ASG1 300
type: UnificationXref
id: Q5ASG1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F6UJE8 64
organism: Monodelphis domestica

AGAP005913-PA
type: ProteinReference
xref: uniprot Q7Q6D2 201
organism: Anopheles gambiae

AGAP005912-PA
type: ProteinReference
xref: uniprot Q7Q6D3 202
organism: Anopheles gambiae

Bos taurus
type: BioSource
xref: ncbitaxon 9913 13

uniprot P16905 360
type: UnificationXref
id: P16905
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 5

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q3W7 98
organism: Pan troglodytes

PTHR13809:SF26
type: RelationshipXref
id: PTHR13809:SF26
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r51
controller: cAMP

uniprot Q90Z40 213
type: UnificationXref
id: Q90Z40
db: uniprot

uniprot Q3T0Y8 299
type: UnificationXref
id: Q3T0Y8
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q28H40 177
organism: Xenopus tropicalis

uniprot F6XYX9 249
type: UnificationXref
id: F6XYX9
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P30671 132
organism: Bos taurus

P01049
type: UnificationXref
id: P01049
db: PANTHER Pathway Component

uniprot Q08C49 377
type: UnificationXref
id: Q08C49
db: uniprot

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P31324 369
xref: PTHR11635:SF156
organism: Mus musculus

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa13 444
cellular location: synaptic vesicle
comment: SPECIES_TYPE=ION

G protein alpha i subunit
type: ProteinReference
xref: uniprot P20353 126
xref: PTHR10218:SF310
organism: Drosophila melanogaster

P01050
type: UnificationXref
id: P01050
db: PANTHER Pathway Component

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 28

Metabotropic glutamate receptor 2
type: ProteinReference
xref: PTHR24060:SF147
xref: uniprot Q14BI2 234
organism: Mus musculus

P01051
type: UnificationXref
id: P01051
db: PANTHER Pathway Component

uniprot Q7Q6D3 202
type: UnificationXref
id: Q7Q6D3
db: uniprot

Adenylate cyclase type 10
type: ProteinReference
xref: uniprot Q8C0T9 420
xref: PTHR16305:SF28
organism: Mus musculus

AGAP008039-PA (Fragment)
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot Q7Q3T7 387
organism: Anopheles gambiae

P01052
type: UnificationXref
id: P01052
db: PANTHER Pathway Component

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot F1A421 49
organism: Dictyostelium purpureum

ncbitaxon 9258 5
type: UnificationXref
id: 9258
db: ncbitaxon

cAMP-dependent protein kinase catalytic subunit 1
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot P12370 357
organism: Drosophila melanogaster

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 38

Voltage-dependent R-type calcium channel subunit alpha-1E
type: ProteinReference
xref: PTHR45628:SF5
xref: uniprot Q07652 413
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NGS8 17
organism: Bos taurus

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 101
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7G7I9 88
organism: Ornithorhynchus anatinus

VAMP3 isoform 1
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot G2HIJ9 255
organism: Pan troglodytes

G protein s5 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-protein
stoichiometric coefficient: 1.0

PTHR45701:SF10
type: RelationshipXref
id: PTHR45701:SF10
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9606 9
type: UnificationXref
id: 9606
db: ncbitaxon

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P31323 368
xref: PTHR11635:SF156
organism: Homo sapiens

AGAP002578-PB
type: ProteinReference
xref: PTHR45628:SF7
xref: uniprot F5HKU8 403
organism: Anopheles gambiae

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF126
xref: uniprot P31321 367
organism: Homo sapiens

uniprot A0A2I3TBK2 398
type: UnificationXref
id: A0A2I3TBK2
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7CFG8 77
organism: Monodelphis domestica

P01047
type: UnificationXref
id: P01047
db: PANTHER Pathway Component

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 10

P01048
type: UnificationXref
id: P01048
db: PANTHER Pathway Component

uniprot P61952 151
type: UnificationXref
id: P61952
db: uniprot

uniprot F6YNZ0 226
type: UnificationXref
id: F6YNZ0
db: uniprot

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P12369 356
organism: Rattus norvegicus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: uniprot P12367 354
xref: PTHR11635:SF153
organism: Mus musculus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P12368 355
organism: Rattus norvegicus

ncbitaxon 5786 50
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot E2R2S8 39
type: UnificationXref
id: E2R2S8
db: uniprot

uniprot F7D9M6 418
type: UnificationXref
id: F7D9M6
db: uniprot

Syntaxin-1B
type: ProteinReference
xref: PTHR19957:SF334
xref: uniprot P61265 280
organism: Rattus norvegicus

Syntaxin-1B
type: ProteinReference
xref: PTHR19957:SF334
xref: uniprot P61264 279
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7GI54 89
organism: Monodelphis domestica

uniprot F6V461 65
type: UnificationXref
id: F6V461
db: uniprot

uniprot F6WM87 333
type: UnificationXref
id: F6WM87
db: uniprot

SNAP25 homologous protein SNAP33
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9S7P9 313
organism: Arabidopsis thaliana

Guanine nucleotide-binding protein G(t) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF68
xref: uniprot P19087 125
organism: Homo sapiens

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot Q9VH76 315
organism: Drosophila melanogaster

uniprot A0A2I3S4R3 14
type: UnificationXref
id: A0A2I3S4R3
db: uniprot

Guanine nucleotide-binding protein subunit gamma-1
type: ProteinReference
xref: uniprot P38040 135
organism: Drosophila melanogaster

uniprot Q5R1X1 302
type: UnificationXref
id: Q5R1X1
db: uniprot

uniprot Q9BV40 309
type: UnificationXref
id: Q9BV40
db: uniprot

PTHR19957:SF84
type: RelationshipXref
id: PTHR19957:SF84
db: PANTHER Family
relationship type: By Homology

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa9 436
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Gnb3 protein
type: ProteinReference
xref: uniprot Q6P025 191
organism: Danio rerio

Brain-derived neurotrophic factor
type: DnaReference
xref: PTHR11589:SF3
organism: Pan troglodytes

uniprot E2RJB3 45
type: UnificationXref
id: E2RJB3
db: uniprot

uniprot P63024 283
type: UnificationXref
id: P63024
db: uniprot

Guanine nucleotide binding protein, beta subunit
type: ProteinReference
xref: uniprot E9FUX0 46
organism: Daphnia pulex

uniprot P50151 143
type: UnificationXref
id: P50151
db: uniprot

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: uniprot P51817 372
xref: PTHR24353:SF133
organism: Homo sapiens

uniprot H2QUV3 228
type: UnificationXref
id: H2QUV3
db: uniprot

uniprot B2RSH2 26
type: UnificationXref
id: B2RSH2
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha-activating activity polypeptide O, b
type: ProteinReference
xref: PTHR10218:SF331
xref: uniprot Q6P967 192
organism: Danio rerio

Syntaxin-1B
type: ProteinReference
xref: PTHR19957:SF334
xref: uniprot P61266 281
organism: Homo sapiens

Syntaxin-1B
type: ProteinReference
xref: PTHR19957:SF334
xref: uniprot P61267 282
organism: Bos taurus

Complex (SNARE Complex/Ca2+)
type: Complex
component stoichiometry: SNARE Complex s13 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ca2 PLUS s14 sa13 STOICHIOMETRY ID COMPLEX
component: SNARE Complex
component: Ca2+
feature: COMPLEX BINDING FEATURE s85 a96 443
feature: COMPLEX BINDING FEATURE s85 a96 441
cellular location: synaptic vesicle

uniprot Q9WUF4 317
type: UnificationXref
id: Q9WUF4
db: uniprot

uniprot Q6P967 192
type: UnificationXref
id: Q6P967
db: uniprot

uniprot P62872 155
type: UnificationXref
id: P62872
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha transducing activity polypeptide 2
type: ProteinReference
xref: PTHR10218:SF68
xref: uniprot F6WX39 69
organism: Xenopus tropicalis

STX1A isoform 3
type: ProteinReference
xref: uniprot H2QUQ1 259
xref: PTHR19957:SF84
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 59
organism: Monodelphis domestica

uniprot Q8WSS1 210
type: UnificationXref
id: Q8WSS1
db: uniprot

uniprot P63044 287
type: UnificationXref
id: P63044
db: uniprot

Ca2 PLUS s14 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot P19087 125
type: UnificationXref
id: P19087
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 72
organism: Monodelphis domestica

THO complex subunit, putative
type: ProteinReference
xref: uniprot B7Q3T6 27
organism: Ixodes scapularis

mGluR2/3
type: Protein
entity reference: mGluR2/3
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa8 434
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot P51817 372
type: UnificationXref
id: P51817
db: uniprot

uniprot P61266 281
type: UnificationXref
id: P61266
db: uniprot

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: PTHR11635:SF162
xref: uniprot P81900 375
organism: Drosophila melanogaster

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: PTHR24353:SF137
xref: uniprot P22612 363
organism: Homo sapiens

ATP
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa11 440
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XHP0 70
organism: Macaca mulatta

uniprot F1PVP1 245
type: UnificationXref
id: F1PVP1
db: uniprot

uniprot P32851 272
type: UnificationXref
id: P32851
db: uniprot

Glutamate s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

mGluR2 3 s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR2/3
stoichiometric coefficient: 1.0

uniprot H2PZA6 94
type: UnificationXref
id: H2PZA6
db: uniprot

Syntaxin-1A isoform 1
type: ProteinReference
xref: PTHR19957:SF84
xref: uniprot A0A1D5QEM1 236
organism: Macaca mulatta

uniprot P36408 133
type: UnificationXref
id: P36408
db: uniprot

uniprot Q5TZ66 303
type: UnificationXref
id: Q5TZ66
db: uniprot

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P26308 128
organism: Drosophila melanogaster

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot F6Q9S4 330
organism: Bos taurus

uniprot Q9Z286 422
type: UnificationXref
id: Q9Z286
db: uniprot

uniprot P30671 132
type: UnificationXref
id: P30671
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CXD0 79
organism: Monodelphis domestica

Protein kinase cAMP-activated catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H2QFK0 338
organism: Pan troglodytes

Guanine nucleotide-binding protein G(t) subunit alpha-2
type: ProteinReference
xref: uniprot P04696 109
xref: PTHR10218:SF68
organism: Bos taurus

uniprot P38400 136
type: UnificationXref
id: P38400
db: uniprot

uniprot P29387 130
type: UnificationXref
id: P29387
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 200

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 51
organism: Bos taurus

uniprot D3ZLD6 32
type: UnificationXref
id: D3ZLD6
db: uniprot

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot H2RER5 342
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR24060:SF160
xref: uniprot F6YNZ0 226
organism: Macaca mulatta

ncbitaxon 284812 173
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot Q8MLZ3 392
type: UnificationXref
id: Q8MLZ3
db: uniprot

uniprot P63026 285
type: UnificationXref
id: P63026
db: uniprot

uniprot P29829 131
type: UnificationXref
id: P29829
db: uniprot

uniprot Q0VFC4 171
type: UnificationXref
id: Q0VFC4
db: uniprot

PTHR24353:SF67
type: RelationshipXref
id: PTHR24353:SF67
db: PANTHER Family
relationship type: By Homology

uniprot P10644 353
type: UnificationXref
id: P10644
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7BB02 76
organism: Macaca mulatta

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 208
organism: Danio rerio

uniprot Q803H5 208
type: UnificationXref
id: Q803H5
db: uniprot

uniprot P17343 120
type: UnificationXref
id: P17343
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot A8X8S6 241
organism: Caenorhabditis briggsae

uniprot Q61011 186
type: UnificationXref
id: Q61011
db: uniprot

ncbitaxon 665079 23
type: UnificationXref
id: 665079
db: ncbitaxon

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q63666 305
organism: Rattus norvegicus

uniprot G3X7Z2 405
type: UnificationXref
id: G3X7Z2
db: uniprot

GO GO:0005634 4
type: UnificationXref
id: GO:0005634
db: GO

uniprot Q9MZL7 417
type: UnificationXref
id: Q9MZL7
db: uniprot

Guanine nucleotide-binding protein alpha-2 subunit
type: ProteinReference
xref: uniprot P22454 127
xref: PTHR10218:SF245
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3KRE3 178
organism: Rattus norvegicus

uniprot F6WJB1 248
type: UnificationXref
id: F6WJB1
db: uniprot

uniprot Q0V7N0 290
type: UnificationXref
id: Q0V7N0
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot E2RHY4 44
organism: Canis lupus familiaris

GRM3 protein
type: ProteinReference
xref: PTHR24060:SF160
xref: uniprot A5D7D8 222
organism: Bos taurus

uniprot C3XY80 29
type: UnificationXref
id: C3XY80
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot O60262 108
organism: Homo sapiens

PTHR24353:SF82
type: RelationshipXref
id: PTHR24353:SF82
db: PANTHER Family
relationship type: By Homology

GDP s6 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
type: ProteinReference
xref: uniprot Q3ZCA7 180
xref: PTHR10218:SF230
organism: Bos taurus

uniprot F6YMH2 250
type: UnificationXref
id: F6YMH2
db: uniprot

uniprot P63045 288
type: UnificationXref
id: P63045
db: uniprot

AC
type: Protein
entity reference: AC
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot Q922R0 394
type: UnificationXref
id: Q922R0
db: uniprot

uniprot F7EBQ5 334
type: UnificationXref
id: F7EBQ5
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot D3ZLD6 32
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR11635:SF126
xref: uniprot A0A1D5PCI4 320
organism: Gallus gallus

GO GO:0043679 3
type: UnificationXref
id: GO:0043679
db: GO

uniprot F6RIM7 61
type: UnificationXref
id: F6RIM7
db: uniprot

PTHR19305:SF5
type: RelationshipXref
id: PTHR19305:SF5
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF37
type: RelationshipXref
id: PTHR24353:SF37
db: PANTHER Family
relationship type: By Homology

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 173

PTHR19305:SF9
type: RelationshipXref
id: PTHR19305:SF9
db: PANTHER Family
relationship type: By Homology

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Glutamate-RIGHT__Glutamate-_r52
control type: ACTIVATION
controller: Complex (SNARE Complex/Ca2+)

uniprot H2R892 229
type: UnificationXref
id: H2R892
db: uniprot

Voltage-dependent calcium channel type A subunit alpha-1
type: ProteinReference
xref: PTHR45628:SF7
xref: uniprot P91645 408
organism: Drosophila melanogaster

PTHR19305:SF4
type: RelationshipXref
id: PTHR19305:SF4
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF162
type: RelationshipXref
id: PTHR11635:SF162
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

uniprot F6Z5I2 251
type: UnificationXref
id: F6Z5I2
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q0VFC4 171
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r54 454
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r54 455
type: Stoichiometry
physical entity: Complex (mGluR2/3/ Glutamate)
stoichiometric coefficient: 1.0

uniprot O95721 268
type: UnificationXref
id: O95721
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6TH03 197
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F7D9M6 418
xref: PTHR16305:SF28
organism: Macaca mulatta

ncbitaxon 6669 47
type: UnificationXref
id: 6669
db: ncbitaxon

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot Q20636 176
organism: Caenorhabditis elegans

uniprot A0A1D5QIS2 237
type: UnificationXref
id: A0A1D5QIS2
db: uniprot

uniprot F6Q9S4 330
type: UnificationXref
id: F6Q9S4
db: uniprot

PARTICIPANT STOICHIOMETRY r53 456
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r57 469
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 457
type: Stoichiometry
physical entity: Complex (mGluR2/3/ G-protein/GDP)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r57 468
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 458
type: Stoichiometry
physical entity: Complex (mGluR2/3/ Glutamate/G-protein/ GDP)
stoichiometric coefficient: 1.0

uniprot P50153 144
type: UnificationXref
id: P50153
db: uniprot

GNB4 protein
type: ProteinReference
xref: uniprot A5PKD6 21
organism: Bos taurus

Ca2+
type: Protein
entity reference: Ca2+
feature: ACTIVE 319
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 9

PTHR11635:SF157
type: RelationshipXref
id: PTHR11635:SF157
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot F7FD32 85
organism: Macaca mulatta

PTHR11635:SF156
type: RelationshipXref
id: PTHR11635:SF156
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF153
type: RelationshipXref
id: PTHR11635:SF153
db: PANTHER Family
relationship type: By Homology

uniprot P50149 141
type: UnificationXref
id: P50149
db: uniprot

PTHR11635:SF152
type: RelationshipXref
id: PTHR11635:SF152
db: PANTHER Family
relationship type: By Homology

uniprot R4GKD1 220
type: UnificationXref
id: R4GKD1
db: uniprot

uniprot M9PE71 261
type: UnificationXref
id: M9PE71
db: uniprot

PTHR11635:SF159
type: RelationshipXref
id: PTHR11635:SF159
db: PANTHER Family
relationship type: By Homology

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q28HP6 297
organism: Xenopus tropicalis

Ca2+
type: ProteinReference
xref: P01051
standard name: Calcium Channel
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES= Long Name: Calcium Channel Synonym: Ca++ Channel,Ca2+ channel Accession: P01051
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group II pathway.PROTEIN.ION_CHANNEL.Ca_super_2+
member entity reference: Voltage-dependent L-type calcium channel subunit beta-1
member entity reference: Voltage-dependent R-type calcium channel subunit alpha-1E
member entity reference: Voltage-dependent calcium channel type A subunit alpha-1
member entity reference: Voltage-dependent R-type calcium channel subunit alpha
member entity reference: AGAP002578-PB
member entity reference: Uncharacterized protein
member entity reference: Calcium voltage-gated channel auxiliary subunit beta 1
member entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
member entity reference: Protein CBR-UNC-2 (Fragment)
member entity reference: Voltage-dependent N-type calcium channel subunit alpha-1B
member entity reference: Voltage-dependent N-type calcium channel subunit alpha
member entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha

uniprot Q17QQ3 294
type: UnificationXref
id: Q17QQ3
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot Q7ZW82 207
organism: Danio rerio

cAMP-dependent protein kinase catalytic subunit alpha isoform 1
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H9EQQ4 344
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HAK5 337
xref: PTHR11635:SF153
organism: Macaca mulatta

Voltage-dependent N-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR10037:SF289
xref: uniprot G3X7Z2 405
organism: Bos taurus

uniprot E1C795 36
type: UnificationXref
id: E1C795
db: uniprot

STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r51
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 461
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 462
left: PKA
interaction type: STATE_TRANSITION
right: PKA

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 266

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P22694 364
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r54 451
type: Stoichiometry
physical entity: Complex (mGluR2/3/ Glutamate/G-protein/ GDP)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r54 453
type: Stoichiometry
physical entity: Complex (GTP/G-protein)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r54 452
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

ncbitaxon 7955 12
type: UnificationXref
id: 7955
db: ncbitaxon

PTHR45628:SF7
type: RelationshipXref
id: PTHR45628:SF7
db: PANTHER Family
relationship type: By Homology

uniprot F7FD32 85
type: UnificationXref
id: F7FD32
db: uniprot

PTHR45628:SF6
type: RelationshipXref
id: PTHR45628:SF6
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E1C795 36
organism: Gallus gallus

PTHR45628:SF5
type: RelationshipXref
id: PTHR45628:SF5
db: PANTHER Family
relationship type: By Homology

G-protein
type: Protein
entity reference: G-protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa10 438
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

PTHR45628:SF3
type: RelationshipXref
id: PTHR45628:SF3
db: PANTHER Family
relationship type: By Homology

uniprot P05987 351
type: UnificationXref
id: P05987
db: uniprot

PRKAR2A isoform 1
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot K7AEL3 345
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot R4GKD1 220
organism: Gallus gallus

AGAP010589-PA
type: ProteinReference
xref: uniprot Q7Q8S4 205
organism: Anopheles gambiae

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 83
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NLV4 52
organism: Gallus gallus

Glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V8K2 93
organism: Rattus norvegicus

uniprot A0A1D5QYR9 238
type: UnificationXref
id: A0A1D5QYR9
db: uniprot

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot P31109 271
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r51 462
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 461
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

AGAP001384-PA
type: ProteinReference
xref: uniprot Q7PXF7 386
xref: PTHR24353:SF117
organism: Anopheles gambiae

PTHR10218:SF73
type: RelationshipXref
id: PTHR10218:SF73
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot A7EDU2 22
organism: Sclerotinia sclerotiorum

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot P54406 149
organism: Caenorhabditis elegans

uniprot Q6PC54 306
type: UnificationXref
id: Q6PC54
db: uniprot

TRANSCRIPTION
type: RelationshipTypeVocabulary

cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B
type: ProteinReference
xref: PTHR11635:SF159
xref: uniprot Q8MM62 393
organism: Dictyostelium discoideum

uniprot H2QUY0 102
type: UnificationXref
id: H2QUY0
db: uniprot

SNAP29 isoform 1
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot H2QLA1 258
organism: Pan troglodytes

G protein subunit alpha i3
type: ProteinReference
xref: uniprot Q5I080 183
xref: PTHR10218:SF230
organism: Xenopus tropicalis

uniprot A7MBH9 24
type: UnificationXref
id: A7MBH9
db: uniprot

uniprot Q8MM62 393
type: UnificationXref
id: Q8MM62
db: uniprot

PARTICIPANT STOICHIOMETRY r52 459
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 134

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F2Z3T8 55
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P36600 371
organism: Schizosaccharomyces pombe

PTHR10218:SF68
type: RelationshipXref
id: PTHR10218:SF68
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF129
type: RelationshipXref
id: PTHR11635:SF129
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein alpha-3 subunit
type: ProteinReference
xref: PTHR10218:SF245
xref: uniprot P28052 129
organism: Caenorhabditis elegans

ncbitaxon 8364 20
type: UnificationXref
id: 8364
db: ncbitaxon

BDNF
type: DnaRegion
entity reference: brain-derived neurotrophic factor
cellular location: nucleus
comment: SPECIES_TYPE=GENE

uniprot Q5E9F0 182
type: UnificationXref
id: Q5E9F0
db: uniprot

PTHR11635:SF126
type: RelationshipXref
id: PTHR11635:SF126
db: PANTHER Family
relationship type: By Homology

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa5 432
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Glutamate metabotropic receptor 2
type: ProteinReference
xref: PTHR24060:SF147
xref: uniprot E1BAB4 223
organism: Bos taurus

uniprot H2PZL0 96
type: UnificationXref
id: H2PZL0
db: uniprot

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 273

uniprot P83351 289
type: UnificationXref
id: P83351
db: uniprot

PARTICIPANT STOICHIOMETRY r52 460
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

uniprot E1BW98 35
type: UnificationXref
id: E1BW98
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot P61954 153
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7E376 105
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot P61952 151
organism: Homo sapiens

uniprot A9JTC8 25
type: UnificationXref
id: A9JTC8
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot P61953 152
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 209
organism: Mus musculus

Ca2+
type: Protein
entity reference: Ca2+
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot P11017 116
type: UnificationXref
id: P11017
db: uniprot

mGluR2 3 s9 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR2/3
stoichiometric coefficient: 1.0

G-protein
type: Protein
entity reference: G-protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa7 426
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q90Z40 213
organism: Danio rerio

uniprot Q9DBC7 395
type: UnificationXref
id: Q9DBC7
db: uniprot

uniprot P00515 347
type: UnificationXref
id: P00515
db: uniprot

uniprot P62880 159
type: UnificationXref
id: P62880
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 74
organism: Macaca mulatta

uniprot F1A421 49
type: UnificationXref
id: F1A421
db: uniprot

uniprot Q24547 296
type: UnificationXref
id: Q24547
db: uniprot

uniprot F7E427 80
type: UnificationXref
id: F7E427
db: uniprot

uniprot P54311 147
type: UnificationXref
id: P54311
db: uniprot

uniprot F6VL43 67
type: UnificationXref
id: F6VL43
db: uniprot

mGluR2/3
type: ProteinReference
xref: P01048
standard name: Metabotropic Glutamate Receptor 2 and 3
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group II pathway.PROTEIN.RECEPTOR.mGluR2/3
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: GRM3 isoform 1
member entity reference: Metabotropic glutamate receptor 2
member entity reference: Metabotropic glutamate receptor 3
member entity reference: Glutamate metabotropic receptor 2
member entity reference: Uncharacterized protein
member entity reference: GRM2 isoform 3
member entity reference: GRM3 protein
member entity reference: Metabotropic glutamate receptor 2 isoform a

t-SNARE protein aex-4
type: ProteinReference
xref: uniprot G5EEN8 256
organism: Caenorhabditis elegans

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: PTHR11824:SF17
xref: uniprot Q02641 412
organism: Homo sapiens

uniprot P08754 114
type: UnificationXref
id: P08754
db: uniprot

Protein kinase A catalytic subunit isoform 2
type: ProteinReference
xref: PTHR24353:SF67
xref: uniprot E9AFM1 325
organism: Leishmania major

ncbitaxon 6239 121
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot O60262 108
type: UnificationXref
id: O60262
db: uniprot

uniprot A0A2J8N6N1 399
type: UnificationXref
id: A0A2J8N6N1
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot P23763 270
organism: Homo sapiens

G protein subunit beta 3
type: ProteinReference
xref: uniprot H2R3A6 103
organism: Pan troglodytes

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F7A472 75
organism: Xenopus tropicalis

PTHR24060:SF160
type: RelationshipXref
id: PTHR24060:SF160
db: PANTHER Family
relationship type: By Homology

uniprot F6VKI4 66
type: UnificationXref
id: F6VKI4
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

uniprot Q1MTI1 295
type: UnificationXref
id: Q1MTI1
db: uniprot

TRANSPORT
type: InteractionVocabulary

G protein subunit alpha transducin 2
type: ProteinReference
xref: PTHR10218:SF68
xref: uniprot E2R4I7 40
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot F7G4Q0 335
organism: Monodelphis domestica

GTP
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PRKACG isoform 1
type: ProteinReference
xref: PTHR24353:SF137
xref: uniprot H2QXB9 339
organism: Pan troglodytes

PTHR24060:SF147
type: RelationshipXref
id: PTHR24060:SF147
db: PANTHER Family
relationship type: By Homology

uniprot Q96PN6 421
type: UnificationXref
id: Q96PN6
db: uniprot

uniprot H2RI77 343
type: UnificationXref
id: H2RI77
db: uniprot

uniprot P63217 168
type: UnificationXref
id: P63217
db: uniprot

uniprot P00517 348
type: UnificationXref
id: P00517
db: uniprot

uniprot P04899 111
type: UnificationXref
id: P04899
db: uniprot

Guanine nucleotide-binding protein alpha-4 subunit
type: ProteinReference
xref: PTHR10218:SF340
xref: uniprot Q9BIG5 214
organism: Caenorhabditis elegans

uniprot F7CFG8 77
type: UnificationXref
id: F7CFG8
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 326

uniprot P16912 361
type: UnificationXref
id: P16912
db: uniprot

uniprot P50146 140
type: UnificationXref
id: P50146
db: uniprot

eco ECO:0000305 273
type: UnificationXref
id: ECO:0000305
db: eco

uniprot F7GQC5 90
type: UnificationXref
id: F7GQC5
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r56
controller: PKA

uniprot H2R3A6 103
type: UnificationXref
id: H2R3A6
db: uniprot

uniprot Q6TH03 197
type: UnificationXref
id: Q6TH03
db: uniprot

Voltage-dependent R-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot A0A3Q1LZY8 400
xref: PTHR45628:SF5
organism: Bos taurus

uniprot A4IGZ2 19
type: UnificationXref
id: A4IGZ2
db: uniprot

Complex (mGluR2/3/ G-protein/GDP)
type: Complex
component stoichiometry: mGluR2 3 s3 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s6 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: G protein s5 sa4 STOICHIOMETRY ID COMPLEX
component: mGluR2/3
component: G-protein
component: GDP
feature: COMPLEX BINDING FEATURE s69 a79 429
feature: COMPLEX BINDING FEATURE s69 a79 427
feature: COMPLEX BINDING FEATURE s69 a79 431
cellular location: axon terminus

ncbitaxon 6238 242
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot Q61017 188
type: UnificationXref
id: Q61017
db: uniprot

uniprot P63027 286
type: UnificationXref
id: P63027
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ERP8 82
organism: Ornithorhynchus anatinus

uniprot Q0VFR6 291
type: UnificationXref
id: Q0VFR6
db: uniprot

uniprot Q15836 292
type: UnificationXref
id: Q15836
db: uniprot

uniprot F7ERP8 82
type: UnificationXref
id: F7ERP8
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P36408 133
organism: Dictyostelium discoideum

ncbitaxon 13616 60
type: UnificationXref
id: 13616
db: ncbitaxon

ncbitaxon 44689 134
type: UnificationXref
id: 44689
db: ncbitaxon

cGMP-dependent 3',5'-cGMP phosphodiesterase A
type: ProteinReference
xref: uniprot Q8MLZ3 392
xref: PTHR11635:SF157
organism: Dictyostelium discoideum

uniprot Q28H40 177
type: UnificationXref
id: Q28H40
db: uniprot

uniprot P63077 161
type: UnificationXref
id: P63077
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta isoform 1
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot F7EBQ5 334
organism: Macaca mulatta

SNARE Complex s61 a95 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=