Voltage-dependent N-type calcium channel subunit alpha-1B
Guanine nucleotide-binding protein subunit gamma
cAMP-dependent protein kinase regulatory subunit
cAMP-dependent protein kinase catalytic subunit alpha
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Guanine nucleotide-binding protein subunit beta-5
Protein kinase cAMP-activated catalytic subunit beta
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Putative synaptobrevin homologue SNC1/2 (Eurofung)
Guanine nucleotide binding protein, beta 3
Guanine nucleotide-binding protein G(O) subunit alpha 1
cAMP-dependent protein kinase catalytic subunit beta
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Vesicle-associated membrane protein 8 (Endobrevin)
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
Metabotropic glutamate receptor group II pathway
MODEL_NOTES=Panther Pathway: P00040 Group II Metabotropic Glutamate Receptors are composed of two receptor proteins, mGlu2 and mGlu3, which are negatively coupled to PKA and intracellular cAMP signalling. These receptors are found in forebrain and cerebellum. Evidence suggests that glutamatergic neuronal transmission is involved in psychiatric and neurological disorders and that drugs that target glutamate systems may serve as novel therapeutics in humans. For example, agonists for group II mGlu receptors (mGlu2 and mGlu3) have been shown to be anxiolytic in certain animal models and have shown promise in early human trials. Lilly is developing LY-354740, the lead compound in a series of derivatives of the metabotropic glutamate receptor group II agonist L-CCG-1, for the potential treatment of anxiety. Website=http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12789623 Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14684454 PMID: 12789623 PMID: 14684454
Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
Protein kinase, cAMP-dependent, catalytic, beta a
Protein kinase cAMP-dependent type II regulatory subunit alpha
Protein kinase cAMP-dependent type I regulatory subunit alpha
Guanine nucleotide-binding protein alpha-17 subunit
Guanine nucleotide-binding protein G(k) subunit alpha
cAMP-dependent protein kinase catalytic subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
Calcium voltage-gated channel auxiliary subunit beta 1
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Guanine nucleotide-binding protein G(i) subunit alpha-1
Guanine nucleotide-binding protein G(t) subunit alpha-2
cAMP-dependent protein kinase type I-beta regulatory subunit
cAMP-dependent protein kinase type I-alpha regulatory subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
cAMP-dependent protein kinase type II-beta regulatory subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Guanine nucleotide-binding protein subunit beta-2
Guanine nucleotide-binding protein G(i) subunit alpha-2
Guanine nucleotide-binding protein G(o) subunit alpha
Guanine nucleotide-binding protein subunit beta-1
ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group II pathway.GENE.GENE.BDNF
ENTITY_REFERENCE_NOTES= Long Name: brain-derived neurotrophic factor Synonym: Synonym not specified Accession: G01540
cAMP-dependent protein kinase type II-alpha regulatory subunit
Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
Guanine nucleotide-binding protein G(K) subunit alpha
Voltage-dependent L-type calcium channel subunit beta-1
Guanine nucleotide-binding protein subunit beta-4
Guanine nucleotide-binding protein subunit beta
Guanine nucleotide-binding protein subunit beta-5b
Protein kinase cAMP-dependent type II regulatory subunit beta
ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group II pathway.PROTEIN.GENERIC.G-protein
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
Complex (mGluR2/3/ Glutamate/G-protein/ GDP)
ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group II pathway.PROTEIN.GENERIC.AC
ENTITY_REFERENCE_NOTES= Long Name: Adenylate Cyclase Synonym: AC Accession: P01052
Putative SNAP25 homologous protein SNAP30
Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
Voltage-dependent R-type calcium channel subunit alpha-1E
Metabotropic glutamate receptor 2 isoform a
Voltage-dependent R-type calcium channel subunit alpha
cAMP-dependent protein kinase catalytic subunit 3
Guanine nucleotide-binding protein (G protein), beta 5
cAMP-dependent protein kinase type I regulatory subunit
Protein kinase, cAMP-dependent, catalytic, beta
Protein kinase A catalytic subunit isoform 1
Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2b
Brain-derived neurotrophic factor (Fragment)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
N-ethylmaleimide-sensitive factor attachment protein receptor
ENTITY_REFERENCE_NOTES= Long Name: N-ethylmaleimide-sensitive factor attachment protein receptor Synonym: SNARE Accession: P01049
ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group II pathway.PROTEIN.GENERIC.SNARE Complex
Voltage-dependent P/Q-type calcium channel subunit alpha
ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group II pathway.PROTEIN.GENERIC.PKA
ENTITY_REFERENCE_NOTES= Long Name: Protein Kinase A Synonym: PKA Accession: P01050
cAMP-dependent protein kinase catalytic subunit PRKX
Protein kinase, cAMP-dependent, regulatory, type II, alpha, B
Guanine nucleotide-binding protein G(O) subunit alpha isoform a
Guanine nucleotide-binding protein beta subunit
Protein kinase, cAMP-dependent, regulatory, type I, beta
cAMP-dependent protein kinase catalytic subunit 1
Guanine nucleotide-binding protein subunit gamma-1
Guanine nucleotide binding protein, beta subunit
Guanine nucleotide-binding protein (G protein), alpha-activating activity polypeptide O, b
Guanine nucleotide-binding protein (G protein), alpha transducing activity polypeptide 2
cAMP-dependent protein kinase type II regulatory subunit
cAMP-dependent protein kinase catalytic subunit gamma
Protein kinase cAMP-activated catalytic subunit alpha
Guanine nucleotide-binding protein alpha-2 subunit
Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
Voltage-dependent calcium channel type A subunit alpha-1
ENTITY_REFERENCE_NOTES= Long Name: Calcium Channel Synonym: Ca++ Channel,Ca2+ channel Accession: P01051
ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group II pathway.PROTEIN.ION_CHANNEL.Ca_super_2+
Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
cAMP-dependent protein kinase catalytic subunit alpha isoform 1
Voltage-dependent N-type calcium channel subunit alpha
cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B
Guanine nucleotide-binding protein alpha-3 subunit
ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group II pathway.PROTEIN.RECEPTOR.mGluR2/3
Protein kinase A catalytic subunit isoform 2
Guanine nucleotide-binding protein alpha-4 subunit
cGMP-dependent 3',5'-cGMP phosphodiesterase A
cAMP-dependent protein kinase catalytic subunit beta isoform 1