uniprot P30625 131
type: UnificationXref
id: P30625
db: uniprot

uniprot Q03391 200
type: UnificationXref
id: Q03391
db: uniprot

uniprot Q5BK52 140
type: UnificationXref
id: Q5BK52
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot E2RFB5 28
organism: Canis lupus familiaris

IP3
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 44689 120
type: UnificationXref
id: 44689
db: ncbitaxon

GluR5
type: Protein
entity reference: GluR5
feature: GluR5 s34 sa26 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa26 241
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Homer s29 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Homer
stoichiometric coefficient: 1.0

uniprot Q00961 197
type: UnificationXref
id: Q00961
db: uniprot

Homer scaffold protein 1
type: ProteinReference
xref: PTHR10918:SF3
xref: uniprot E2RT37 90
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r67 284
type: Stoichiometry
physical entity: Complex (GluR5/Glutamate)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r67 283
type: Stoichiometry
physical entity: GluR5
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r67 282
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

uniprot E1BA29 66
type: UnificationXref
id: E1BA29
db: uniprot

PARTICIPANT STOICHIOMETRY r22 281
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 280
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Glutamate metabotropic receptor 1
type: ProteinReference
xref: PTHR24060:SF29
xref: uniprot H2QTV8 155
organism: Pan troglodytes

uniprot F1NMB0 177
type: UnificationXref
id: F1NMB0
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6TQN3 10
xref: PTHR10336:SF106
organism: Monodelphis domestica

uniprot F6T0T9 104
type: UnificationXref
id: F6T0T9
db: uniprot

uniprot P21137 127
type: UnificationXref
id: P21137
db: uniprot

uniprot Q5ZM91 142
type: UnificationXref
id: Q5ZM91
db: uniprot

uniprot Q16478 36
type: UnificationXref
id: Q16478
db: uniprot

uniprot Q2HJD2 37
type: UnificationXref
id: Q2HJD2
db: uniprot

Protein lifeguard 1
type: ProteinReference
xref: uniprot Q6P6R0 210
organism: Rattus norvegicus

Glutamate s24 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

uniprot F6T8S6 180
type: UnificationXref
id: F6T8S6
db: uniprot

PTHR18966:SF407
type: RelationshipXref
id: PTHR18966:SF407
db: PANTHER Family
relationship type: By Homology

uniprot F7EBQ5 106
type: UnificationXref
id: F7EBQ5
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 19

HETERODIMER_ASSOCIATION_LEFT__mGluR1-_Homer-_mGluR5-_Complex__G_Protein_GDP_-RIGHT__Complex__mGluR1_mGluR5__Homer_G_Protein__GDP_-_r59
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 299
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 298
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 301
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 300
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 302
left: mGluR5
left: Homer
left: mGluR1
left: Complex (G-Protein/GDP)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (mGluR1/mGluR5/ Homer/G-Protein/ GDP)

NMDA s32 sa24 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.27

PRKACB isoform 3
type: ProteinReference
xref: uniprot H2R1G3 111
xref: PTHR24353:SF116
organism: Pan troglodytes

PTHR18966:SF400
type: RelationshipXref
id: PTHR18966:SF400
db: PANTHER Family
relationship type: By Homology

ncbitaxon 7227 60
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot Q14643 58
type: UnificationXref
id: Q14643
db: uniprot

uniprot P31424 158
type: UnificationXref
id: P31424
db: uniprot

uniprot H9FVW1 14
type: UnificationXref
id: H9FVW1
db: uniprot

ncbitaxon 9615 9
type: UnificationXref
id: 9615
db: ncbitaxon

Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)
type: ProteinReference
xref: uniprot Q5RKP9 85
xref: PTHR10218:SF328
organism: Danio rerio

G Protein s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

uniprot P00517 116
type: UnificationXref
id: P00517
db: uniprot

uniprot Q13224 203
type: UnificationXref
id: Q13224
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 60

mGluR5 s27 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR5
stoichiometric coefficient: 1.0

By Homology
type: RelationshipTypeVocabulary

uniprot Q05586 201
type: UnificationXref
id: Q05586
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P17612 126
xref: PTHR24353:SF82
organism: Homo sapiens

Glutamate receptor ionotropic, kainate 5
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot Q63273 40
organism: Rattus norvegicus

ncbitaxon 6238 54
type: UnificationXref
id: 6238
db: ncbitaxon

N-methyl D-aspartate receptor subtype 2B
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 165
xref: PTHR18966:SF382
xref: uniprot F6T8S6 180
organism: Macaca mulatta

Glutamate receptor ionotropic, NMDA 2A
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 165
evidence: Evidence 167
evidence: Evidence 166
xref: PTHR18966:SF407
xref: uniprot Q12879 202
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot Q14643 58
xref: PTHR13715:SF52
organism: Homo sapiens

Protein kinase cAMP-activated catalytic subunit beta
type: ProteinReference
xref: uniprot F6T0T9 104
xref: PTHR24353:SF116
organism: Xenopus tropicalis

PTHR10218:SF217
type: RelationshipXref
id: PTHR10218:SF217
db: PANTHER Family
relationship type: By Homology

uniprot P39086 35
type: UnificationXref
id: P39086
db: uniprot

PTHR10218:SF316
type: RelationshipXref
id: PTHR10218:SF316
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__mGluR1-_Homer-RIGHT__Complex__mGluR1_Homer_-_r56
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 310
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 309
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 311
left: Homer
left: mGluR1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (mGluR1/Homer)

Glutamate ionotropic receptor NMDA type subunit 2A
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 165
evidence: Evidence 167
evidence: Evidence 166
xref: PTHR18966:SF407
xref: uniprot F1PXS6 178
organism: Canis lupus familiaris

uniprot G3N3K3 185
type: UnificationXref
id: G3N3K3
db: uniprot

Guanine nucleotide-binding protein subunit alpha-15
type: ProteinReference
xref: PTHR10218:SF217
xref: uniprot O88302 74
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r61 296
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r61 295
type: Stoichiometry
physical entity: Complex (mGluR1/mGluR5/ Homer/G-Protein/ GDP)
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot F6VHF7 51
xref: PTHR13715:SF52
organism: Xenopus tropicalis

GTP s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Homer
type: Protein
entity reference: Homer
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa21 251
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2RI77 113
type: UnificationXref
id: H2RI77
db: uniprot

PARTICIPANT STOICHIOMETRY r61 297
type: Stoichiometry
physical entity: Complex (mGluR1/mGluR5/ Glutamate/Homer/ G-Protein/GDP)
stoichiometric coefficient: 1.0

Glutamate receptor ionotropic, kainate 1
type: ProteinReference
xref: uniprot P22756 34
xref: PTHR18966:SF36
organism: Rattus norvegicus

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 257
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PRKAR1A isoform 12
type: ProteinReference
xref: uniprot H2R3M7 112
xref: PTHR11635:SF129
organism: Pan troglodytes

uniprot P22756 34
type: UnificationXref
id: P22756
db: uniprot

uniprot A0A1D5PCI4 95
type: UnificationXref
id: A0A1D5PCI4
db: uniprot

PTHR10218:SF328
type: RelationshipXref
id: PTHR10218:SF328
db: PANTHER Family
relationship type: By Homology

PTHR10218:SF329
type: RelationshipXref
id: PTHR10218:SF329
db: PANTHER Family
relationship type: By Homology

Glutamate s28 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Protein CBR-NMR-1
type: ProteinReference
evidence: Evidence 165
xref: PTHR18966:SF377
xref: uniprot A8WUE7 171
organism: Caenorhabditis briggsae

uniprot G5EGQ9 186
type: UnificationXref
id: G5EGQ9
db: uniprot

uniprot Q9ESF4 218
type: UnificationXref
id: Q9ESF4
db: uniprot

uniprot E1BK87 172
type: UnificationXref
id: E1BK87
db: uniprot

uniprot P22694 129
type: UnificationXref
id: P22694
db: uniprot

uniprot A0A2I3T979 25
type: UnificationXref
id: A0A2I3T979
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 165
evidence: Evidence 170
xref: PTHR18966:SF397
xref: uniprot F6VTB5 181
organism: Macaca mulatta

Metabotropic glutamate receptor 1
type: ProteinReference
xref: PTHR24060:SF29
xref: uniprot P97772 160
organism: Mus musculus

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 13

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa12 267
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1QEC8 102
type: UnificationXref
id: F1QEC8
db: uniprot

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot P10644 121
xref: PTHR11635:SF129
organism: Homo sapiens

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 32

Metabotropic glutamate receptor 1 isoform beta
type: ProteinReference
xref: PTHR24060:SF29
xref: uniprot F7GU00 154
organism: Macaca mulatta

Glutamate receptor ionotropic, NMDA 3A
type: ProteinReference
evidence: Evidence 165
evidence: Evidence 170
xref: uniprot Q8TCU5 215
xref: PTHR18966:SF397
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR10918:SF3
xref: uniprot F7HNK9 91
organism: Macaca mulatta

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q922R0 149
organism: Mus musculus

TRIGGER
type: RelationshipTypeVocabulary

uniprot Q6ZM67 212
type: UnificationXref
id: Q6ZM67
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P68182 136
xref: PTHR24353:SF116
organism: Rattus norvegicus

Glutamate receptor ionotropic, NMDA 3B
type: ProteinReference
evidence: Evidence 165
evidence: Evidence 170
xref: PTHR18966:SF364
xref: uniprot Q8VHN2 216
organism: Rattus norvegicus

Complex (mGluR1/mGluR5/ Glutamate/Homer/ G-Protein/GDP)
type: Complex
component stoichiometry: Homer s29 sa21 STOICHIOMETRY ID COMPLEX
component stoichiometry: mGluR1 s26 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glutamate s28 sa20 STOICHIOMETRY ID COMPLEX
component stoichiometry: mGluR5 s27 sa19 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s31 sa23 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s30 sa22 STOICHIOMETRY ID COMPLEX
component: G-Protein
component: Glutamate
component: mGluR1
component: GDP
component: Homer
component: mGluR5
feature: COMPLEX BINDING FEATURE s94 a112 244
feature: COMPLEX BINDING FEATURE s94 a112 254
feature: COMPLEX BINDING FEATURE s94 a112 252
feature: COMPLEX BINDING FEATURE s94 a112 246
feature: COMPLEX BINDING FEATURE s94 a112 250
feature: COMPLEX BINDING FEATURE s94 a112 248
cellular location: cytosol

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P68181 135
xref: PTHR24353:SF116
organism: Mus musculus

uniprot F1N2V3 67
type: UnificationXref
id: F1N2V3
db: uniprot

Protein CBR-ITR-1, isoform a
type: ProteinReference
xref: uniprot H8WGV2 53
xref: PTHR13715:SF87
organism: Caenorhabditis briggsae

Uncharacterized protein
type: ProteinReference
xref: PTHR10918:SF3
xref: uniprot A0A1D5PU34 87
organism: Gallus gallus

uniprot F6THW2 69
type: UnificationXref
id: F6THW2
db: uniprot

GluR5 s34 sa26 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.327051932306855
comment: MODIFICATION_RESIDUE_NAME=

GRIK1 isoform 7
type: ProteinReference
xref: uniprot A0A2I3T979 25
xref: PTHR18966:SF36
organism: Pan troglodytes

Complex (mGluR1/mGluR5/ Glutamate/Homer)
type: Complex
component stoichiometry: Homer s25 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glutamate s24 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: mGluR5 s23 sa15 STOICHIOMETRY ID COMPLEX
component stoichiometry: mGluR1 s22 sa14 STOICHIOMETRY ID COMPLEX
component: Glutamate
component: mGluR1
component: mGluR5
component: Homer
feature: COMPLEX BINDING FEATURE s86 a100 222
feature: COMPLEX BINDING FEATURE s86 a100 220
feature: COMPLEX BINDING FEATURE s86 a100 224
feature: COMPLEX BINDING FEATURE s86 a100 226
cellular location: cytosol

mGluR1 s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR1
stoichiometric coefficient: 2.0

uniprot O88302 74
type: UnificationXref
id: O88302
db: uniprot

Metabotropic glutamate receptor 1
type: ProteinReference
xref: PTHR24060:SF29
xref: uniprot P23385 157
organism: Rattus norvegicus

uniprot Q13255 161
type: UnificationXref
id: Q13255
db: uniprot

Glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P30625 131
organism: Caenorhabditis elegans

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r63
controller: IP3

uniprot P31321 132
type: UnificationXref
id: P31321
db: uniprot

Metabotropic glutamate receptor 5
type: ProteinReference
xref: uniprot P41594 159
xref: PTHR24060:SF30
organism: Homo sapiens

uniprot A8WUE7 171
type: UnificationXref
id: A8WUE7
db: uniprot

PARTICIPANT STOICHIOMETRY r59 299
type: Stoichiometry
physical entity: Homer
stoichiometric coefficient: 1.0

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

PARTICIPANT STOICHIOMETRY r59 298
type: Stoichiometry
physical entity: mGluR1
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q9QW07 20
organism: Rattus norvegicus

PTHR24356:SF158
type: RelationshipXref
id: PTHR24356:SF158
db: PANTHER Family
relationship type: By Homology

Protein kinase A catalytic subunit
type: ProteinReference
xref: uniprot Q27687 138
xref: PTHR24353:SF37
organism: Leishmania major

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Glutamate-_GluR5-RIGHT__Complex__GluR5_Glutamate_-_r67
controller: PKC

Glutamate ionotropic receptor NMDA type subunit 2A
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 165
evidence: Evidence 167
evidence: Evidence 166
xref: PTHR18966:SF407
xref: uniprot F6YLB3 182
organism: Monodelphis domestica

PIP2
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Glutamate s33 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

uniprot H2QJY5 12
type: UnificationXref
id: H2QJY5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T2 108
xref: PTHR24353:SF37
organism: Macaca mulatta

uniprot Q8MJ44 148
type: UnificationXref
id: Q8MJ44
db: uniprot

GDP s21 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot E2RFB5 28
type: UnificationXref
id: E2RFB5
db: uniprot

uniprot Q7Q3T7 146
type: UnificationXref
id: Q7Q3T7
db: uniprot

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa25 239
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR10918:SF3
type: RelationshipXref
id: PTHR10918:SF3
db: PANTHER Family
relationship type: By Homology

Evidence 191
type: Evidence
evidence code: ISS
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html

Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
type: ProteinReference
xref: uniprot F1QEC8 102
xref: PTHR11635:SF129
organism: Danio rerio

uniprot Q9GNR4 151
type: UnificationXref
id: Q9GNR4
db: uniprot

Glutamate receptor ionotropic, NMDA3A
type: ProteinReference
evidence: Evidence 165
evidence: Evidence 170
xref: uniprot A2AIR5 169
xref: PTHR18966:SF397
organism: Mus musculus

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 3

uniprot P38409 81
type: UnificationXref
id: P38409
db: uniprot

PLC
type: Protein
entity reference: PLC
feature: ACTIVE 22
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Glutamate ionotropic receptor NMDA type subunit 3A
type: ProteinReference
evidence: Evidence 165
evidence: Evidence 170
xref: PTHR18966:SF397
xref: uniprot E2QUL1 173
organism: Canis lupus familiaris

Metabotropic glutamate receptor group I pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Glutamate-_GluR5-RIGHT__Complex__GluR5_Glutamate_-_r67
pathway component: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r63
pathway component: STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_r54
pathway component: STATE_TRANSITION_LEFT__NMDA-_Glutamate-RIGHT__Complex__NMDA_Glutamate_-_r66
pathway component: HETERODIMER_ASSOCIATION_LEFT__Homer-_mGluR5-RIGHT__Complex__mGluR5_Homer_-_r58
pathway component: DISSOCIATION_LEFT__GTP-_Complex__mGluR1_mGluR5__Glutamate_Homer__G_Protein_GDP_-RIGHT__Complex__GTP_G_Protein_-_Complex__mGluR1_mGluR5__Glutamate_Homer_-_GDP-_r62
pathway component: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r52
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__mGluR1_mGluR5__Homer_G_Protein__GDP_-_Glutamate-RIGHT__Complex__mGluR1_mGluR5__Glutamate_Homer__G_Protein_GDP_-_r61
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r53
pathway component: DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r8
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r22
pathway component: HETERODIMER_ASSOCIATION_LEFT__mGluR1-_Homer-_mGluR5-_Complex__G_Protein_GDP_-RIGHT__Complex__mGluR1_mGluR5__Homer_G_Protein__GDP_-_r59
pathway component: HETERODIMER_ASSOCIATION_LEFT__mGluR1-_Homer-RIGHT__Complex__mGluR1_Homer_-_r56
xref: PANTHER Pathway P00041 1
comment: MODEL_NOTES=Panther Pathway: P00041 Group I Metabotropic Glutamate Receptors are composed of two receptor proteins, mGlu1 and mGlu5, which are coupled to PLC and intracellular calcium signalling. These receptors are found in forebrain and cerebellum. To date, evidence has emerged indicating that group I metabotropic glutamate receptor (mGluR1 and mGluR5) antagonists have antidepressant-like activity in a variety of preclinical models. Although evidence now exists that these receptors are potential drug targets for ischemia, schizophrenia, and epilepsy, the clinical applications of agonists and antagonists are only beginning. Website=http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12838033 Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14684451 PMID: 12838033 PMID: 14684451

uniprot Q00959 195
type: UnificationXref
id: Q00959
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r53
controller: PKC

Glutamate ionotropic receptor kainate type subunit 1
type: ProteinReference
xref: uniprot A0A1D5PHB3 23
xref: PTHR18966:SF36
organism: Gallus gallus

Protein kinase, X-linked
type: ProteinReference
xref: uniprot Q5BK52 140
xref: PTHR24353:SF37
organism: Rattus norvegicus

Glutamate [NMDA] receptor subunit 1
type: ProteinReference
evidence: Evidence 165
xref: PTHR18966:SF377
xref: uniprot Q24418 205
organism: Drosophila melanogaster

PKC
type: ProteinReference
xref: P01055
standard name: Protein kinase C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Protein kinase C Synonym: PKC Accession: P01055
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group I pathway.PROTEIN.GENERIC.PKC
member entity reference: Protein kinase C beta type
member entity reference: Protein kinase C

uniprot Q9Z2Y3 94
type: UnificationXref
id: Q9Z2Y3
db: uniprot

uniprot F7G4Q0 107
type: UnificationXref
id: F7G4Q0
db: uniprot

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot Q5ZM91 142
organism: Gallus gallus

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s35 sa27 243
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HPP3 33
xref: PTHR18966:SF351
organism: Macaca mulatta

uniprot G5EGU1 72
type: UnificationXref
id: G5EGU1
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot A0A2I3SSC7 48
xref: PTHR13715:SF52
organism: Pan troglodytes

Homer s7 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Homer
stoichiometric coefficient: 1.0

uniprot Q28FH0 83
type: UnificationXref
id: Q28FH0
db: uniprot

Protein kinase, cAMP-dependent, regulatory, type I, beta
type: ProteinReference
xref: uniprot Q08C49 137
xref: PTHR11635:SF126
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r56 309
type: Stoichiometry
physical entity: mGluR1
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot P21137 127
xref: PTHR24353:SF117
organism: Caenorhabditis elegans

uniprot F7GU00 154
type: UnificationXref
id: F7GU00
db: uniprot

STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_r54
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 275
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 274
left: PLC
interaction type: STATE_TRANSITION
right: PLC

…
type: Stoichiometry
physical entity: mGluR5
stoichiometric coefficient: 2.0

Evidence 166
type: Evidence
evidence code: ISS
comment: Website http://harvester.embl.de/harvester/Q149/Q14957.htm

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VQP7 52
xref: PTHR13715:SF52
organism: Monodelphis domestica

PTHR18966:SF497
type: RelationshipXref
id: PTHR18966:SF497
db: PANTHER Family
relationship type: By Homology

Evidence 165
type: Evidence
evidence code: ISS
comment: Website http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm

PTHR18966:SF397
type: RelationshipXref
id: PTHR18966:SF397
db: PANTHER Family
relationship type: By Homology

ncbitaxon 8364 32
type: UnificationXref
id: 8364
db: ncbitaxon

G Protein s8 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 165
xref: PTHR18966:SF382
xref: uniprot F1NMB0 177
organism: Gallus gallus

DAG
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9598 13
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot H2QTV8 155
type: UnificationXref
id: H2QTV8
db: uniprot

MODULATION
type: RelationshipTypeVocabulary

uniprot Q2KJ56 92
type: UnificationXref
id: Q2KJ56
db: uniprot

Glutamate receptor ionotropic, NMDA 2C
type: ProteinReference
evidence: Evidence 165
evidence: Evidence 166
xref: PTHR18966:SF361
xref: uniprot Q01098 199
organism: Mus musculus

Bos taurus
type: BioSource
xref: ncbitaxon 9913 27

Complex (mGluR1/Homer)
type: Complex
component stoichiometry: Homer s5 sa4 STOICHIOMETRY ID COMPLEX
component: mGluR1
component: Homer
feature: COMPLEX BINDING FEATURE s66 a74 270
feature: COMPLEX BINDING FEATURE s66 a74 272
cellular location: cytosol

Evidence 167
type: Evidence
evidence code: ISS
comment: Website http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436

uniprot P68181 135
type: UnificationXref
id: P68181
db: uniprot

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 165
xref: uniprot Q01097 198
xref: PTHR18966:SF382
organism: Mus musculus

Evidence 168
type: Evidence
evidence code: ISS
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html

uniprot P21279 76
type: UnificationXref
id: P21279
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 15

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot Q9JID2 86
organism: Rattus norvegicus

00696
type: UnificationXref
id: MOD:00696
db: mod

PTHR13715:SF87
type: RelationshipXref
id: PTHR13715:SF87
db: PANTHER Family
relationship type: By Homology

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
type: ProteinReference
xref: PTHR24353:SF135
xref: uniprot Q6DBV8 143
organism: Danio rerio

Protein kinase, cAMP-dependent, catalytic, beta a
type: ProteinReference
xref: uniprot Q7T374 147
xref: PTHR24353:SF116
organism: Danio rerio

PTHR10336:SF106
type: RelationshipXref
id: PTHR10336:SF106
db: PANTHER Family
relationship type: By Homology

Evidence 170
type: Evidence
evidence code: ISS
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html

P01060
type: UnificationXref
id: P01060
db: PANTHER Pathway Component

P01061
type: UnificationXref
id: P01061
db: PANTHER Pathway Component

uniprot P21278 75
type: UnificationXref
id: P21278
db: uniprot

P01062
type: UnificationXref
id: P01062
db: PANTHER Pathway Component

mGluR5 s104 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR5
stoichiometric coefficient: 1.0

PKA
type: Protein
entity reference: PKA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR18966:SF385
type: RelationshipXref
id: PTHR18966:SF385
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Glutamate-_GluR5-RIGHT__Complex__GluR5_Glutamate_-_r67
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 284
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 283
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 282
left: Glutamate
left: GluR5
interaction type: STATE_TRANSITION
right: Complex (GluR5/Glutamate)

PTHR18966:SF382
type: RelationshipXref
id: PTHR18966:SF382
db: PANTHER Family
relationship type: By Homology

uniprot F6PGX6 179
type: UnificationXref
id: F6PGX6
db: uniprot

Glutamate ionotropic receptor NMDA type subunit 3A
type: ProteinReference
evidence: Evidence 165
evidence: Evidence 170
xref: uniprot E1BK87 172
xref: PTHR18966:SF397
organism: Bos taurus

ncbitaxon 13616 11
type: UnificationXref
id: 13616
db: ncbitaxon

PTHR18966:SF377
type: RelationshipXref
id: PTHR18966:SF377
db: PANTHER Family
relationship type: By Homology

Glutamate receptor ionotropic, NMDA 2D
type: ProteinReference
evidence: Evidence 165
evidence: Evidence 191
evidence: Evidence 166
xref: uniprot O15399 190
xref: PTHR18966:SF385
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__Homer-_mGluR5-RIGHT__Complex__mGluR5_Homer_-_r58
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 308
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 306
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 307
left: mGluR5
left: Homer
interaction type: HETERODIMER_ASSOCIATION
right: Complex (mGluR5/Homer)

PTHR24060:SF30
type: RelationshipXref
id: PTHR24060:SF30
db: PANTHER Family
relationship type: By Homology

uniprot P29992 77
type: UnificationXref
id: P29992
db: uniprot

Protein kinase cAMP-dependent type I regulatory subunit alpha
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot F6R7N8 103
organism: Monodelphis domestica

uniprot J9JH96 156
type: UnificationXref
id: J9JH96
db: uniprot

mGluR1
type: Protein
entity reference: mGluR1

IP3R
type: ProteinReference
xref: P01056
standard name: inositol 1,4,5-triphosphate receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES= Long Name: inositol 1,4,5-triphosphate receptor Synonym: ITPR Accession: P01056
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group I pathway.PROTEIN.ION_CHANNEL.IP_sub_3_endsub_R
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1
member entity reference: Inositol 1,4,5-trisphosphate receptor itr-1
member entity reference: Uncharacterized protein
member entity reference: Ryanodine receptor
member entity reference: Protein CBR-ITR-1, isoform a
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1 isoform 3

uniprot P68182 136
type: UnificationXref
id: P68182
db: uniprot

mGluR1
type: Protein
entity reference: mGluR1
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa9 261
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

DISSOCIATION
type: RelationshipTypeVocabulary

P01058
type: UnificationXref
id: P01058
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r53
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 277
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 276
left: PKA
interaction type: STATE_TRANSITION
right: PKA

P01059
type: UnificationXref
id: P01059
db: PANTHER Pathway Component

Homer s12 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Homer
stoichiometric coefficient: 1.0

P01056
type: UnificationXref
id: P01056
db: PANTHER Pathway Component

P01057
type: UnificationXref
id: P01057
db: PANTHER Pathway Component

Metabotropic glutamate receptor 5
type: ProteinReference
xref: uniprot P31424 158
xref: PTHR24060:SF30
organism: Rattus norvegicus

P01054
type: UnificationXref
id: P01054
db: PANTHER Pathway Component

P01055
type: UnificationXref
id: P01055
db: PANTHER Pathway Component

AGAP008039-PA (Fragment)
type: ProteinReference
xref: uniprot Q7Q3T7 146
xref: PTHR24353:SF117
organism: Anopheles gambiae

ncbitaxon 9913 27
type: UnificationXref
id: 9913
db: ncbitaxon

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot A8XW88 97
organism: Caenorhabditis briggsae

P01053
type: UnificationXref
id: P01053
db: PANTHER Pathway Component

uniprot Q01097 198
type: UnificationXref
id: Q01097
db: uniprot

uniprot F7AGW3 30
type: UnificationXref
id: F7AGW3
db: uniprot

cAMP-dependent protein kinase catalytic subunit 1
type: ProteinReference
xref: uniprot P12370 122
xref: PTHR24353:SF117
organism: Drosophila melanogaster

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 9

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_r54
controller: Complex (GTP/G-Protein)

Homer
type: Protein
entity reference: Homer
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa4 273
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Complex (G-Protein/GDP)
type: Complex
component stoichiometry: GDP s9 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s8 sa7 STOICHIOMETRY ID COMPLEX
component: GDP
component: G-Protein
feature: COMPLEX BINDING FEATURE s73 a86 232
feature: COMPLEX BINDING FEATURE s73 a86 234
cellular location: cytosol

PTHR24060:SF29
type: RelationshipXref
id: PTHR24060:SF29
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot P50148 82
organism: Homo sapiens

Glutamate ionotropic receptor kainate type subunit 1
type: ProteinReference
xref: PTHR18966:SF36
xref: uniprot F6S5B1 29
organism: Monodelphis domestica

mGluR5
type: Protein
entity reference: mGluR5
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa19 247
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: uniprot P31321 132
xref: PTHR11635:SF126
organism: Homo sapiens

PTHR18966:SF361
type: RelationshipXref
id: PTHR18966:SF361
db: PANTHER Family
relationship type: By Homology

uniprot Q9QW07 20
type: UnificationXref
id: Q9QW07
db: uniprot

PARTICIPANT STOICHIOMETRY r56 310
type: Stoichiometry
physical entity: Homer
stoichiometric coefficient: 1.0

uniprot K6ZCJ5 73
type: UnificationXref
id: K6ZCJ5
db: uniprot

PARTICIPANT STOICHIOMETRY r56 311
type: Stoichiometry
physical entity: Complex (mGluR1/Homer)
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit alpha-15
type: ProteinReference
xref: uniprot P30678 78
xref: PTHR10218:SF217
organism: Mus musculus

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 5

PTHR18966:SF364
type: RelationshipXref
id: PTHR18966:SF364
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit alpha-15
type: ProteinReference
xref: uniprot P30679 80
xref: PTHR10218:SF217
organism: Homo sapiens

Homer
type: Protein
entity reference: Homer
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa17 227
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q7T374 147
type: UnificationXref
id: Q7T374
db: uniprot

uniprot F1MX21 50
type: UnificationXref
id: F1MX21
db: uniprot

mGluR1
type: Protein
entity reference: mGluR1
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa14 221
feature: ACTIVE 22
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot E7F101 175
type: UnificationXref
id: E7F101
db: uniprot

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF126
xref: uniprot P12849 123
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NWG3 152
xref: PTHR24060:SF30
organism: Gallus gallus

Inositol 1,4,5-trisphosphate receptor type 1 isoform 3
type: ProteinReference
xref: uniprot H9FU38 55
xref: PTHR13715:SF52
organism: Macaca mulatta

Glutamate receptor ionotropic, NMDA 2D
type: ProteinReference
evidence: Evidence 165
evidence: Evidence 191
evidence: Evidence 166
xref: uniprot Q62645 209
xref: PTHR18966:SF385
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot P21278 75
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot F7ECA6 70
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot P21279 76
organism: Mus musculus

Homer protein homolog 1
type: ProteinReference
xref: uniprot Q86YM7 93
xref: PTHR10918:SF3
organism: Homo sapiens

PTHR18966:SF351
type: RelationshipXref
id: PTHR18966:SF351
db: PANTHER Family
relationship type: By Homology

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P27791 130
xref: PTHR24353:SF82
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot A0A3Q2U0G2 4
xref: PTHR10336:SF106
organism: Gallus gallus

uniprot Q922R0 149
type: UnificationXref
id: Q922R0
db: uniprot

Glutamate s35 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PTHR18966:SF36
type: RelationshipXref
id: PTHR18966:SF36
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot F1PLB3 8
organism: Canis lupus familiaris

STATE_TRANSITION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY r54 275
type: Stoichiometry
physical entity: PLC
stoichiometric coefficient: 1.0

uniprot Q8VHN2 216
type: UnificationXref
id: Q8VHN2
db: uniprot

ncbitaxon 6669 101
type: UnificationXref
id: 6669
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r54 274
type: Stoichiometry
physical entity: PLC
stoichiometric coefficient: 1.0

uniprot Q12879 202
type: UnificationXref
id: Q12879
db: uniprot

uniprot F1MCL3 176
type: UnificationXref
id: F1MCL3
db: uniprot

uniprot H2R3M7 112
type: UnificationXref
id: H2R3M7
db: uniprot

Glutamate receptor, ionotropic, N-methyl D-aspartate 1a
type: ProteinReference
evidence: Evidence 165
xref: uniprot E7F101 175
xref: PTHR18966:SF400
organism: Danio rerio

NMDA s98 a114 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.27

N-methyl-D-aspartate receptor type 1 subunit
type: ProteinReference
evidence: Evidence 165
xref: uniprot Q6R6I2 211
xref: PTHR18966:SF377
organism: Gallus gallus

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P68404 47
organism: Mus musculus

Glutamate receptor, ionotropic, kainate 1
type: ProteinReference
xref: uniprot F7BDN8 31
xref: PTHR18966:SF36
organism: Xenopus tropicalis

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot F6WM87 105
organism: Macaca mulatta

Metabotropic glutamate receptor 5 isoform a
type: ProteinReference
xref: uniprot F6SR09 153
xref: PTHR24060:SF30
organism: Macaca mulatta

uniprot P11881 56
type: UnificationXref
id: P11881
db: uniprot

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: PTHR24353:SF133
xref: uniprot P51817 134
organism: Homo sapiens

uniprot A0A3Q2UD13 49
type: UnificationXref
id: A0A3Q2UD13
db: uniprot

GluR5
type: ProteinReference
xref: P01054
standard name: Kainate Receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES= Long Name: Kainate Receptor Synonym: Glu5,GluR5,KA Receptor Accession: P01054
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group I pathway.PROTEIN.ION_CHANNEL.GluR5
member entity reference: Glutamate receptor ionotropic, kainate 1
member entity reference: Glutamate ionotropic receptor kainate type subunit 1
member entity reference: GRIK1 protein
member entity reference: Glutamate receptor ionotropic, kainate 5
member entity reference: Uncharacterized protein
member entity reference: Glutamate ionotropic receptor kainate type subunit 5
member entity reference: Glutamate receptor, ionotropic, kainate 1
member entity reference: Glutamate receptor, ionotropic, kainate 5
member entity reference: GRIK1 isoform 7

uniprot F1PXS6 178
type: UnificationXref
id: F1PXS6
db: uniprot

uniprot Q01098 199
type: UnificationXref
id: Q01098
db: uniprot

Protein lifeguard 1
type: ProteinReference
xref: uniprot Q7Z429 214
organism: Homo sapiens

Guanine nucleotide-binding protein (G protein), q polypeptide
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot Q28FH0 83
organism: Xenopus tropicalis

Prkar1a protein
type: ProteinReference
xref: uniprot Q5I0F6 141
xref: PTHR11635:SF129
organism: Danio rerio

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa13 269
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P05987 119
type: UnificationXref
id: P05987
db: uniprot

Homer protein homolog 1
type: ProteinReference
xref: PTHR10918:SF3
xref: uniprot Q9Z2Y3 94
organism: Mus musculus

uniprot Q00960 196
type: UnificationXref
id: Q00960
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 165
xref: PTHR18966:SF382
xref: uniprot F1MCL3 176
organism: Bos taurus

Homer
type: Protein
entity reference: Homer
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa6 231
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Homer
type: ProteinReference
xref: P01058
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group I pathway.PROTEIN.GENERIC.Homer
comment: ENTITY_REFERENCE_NOTES= Long Name: Homer Synonym: Synonym not specified Accession: P01058
member entity reference: Uncharacterized protein
member entity reference: Homer protein homolog 1
member entity reference: Homer scaffold protein 1

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot H2QAS6 44
organism: Pan troglodytes

uniprot B8JLJ7 64
type: UnificationXref
id: B8JLJ7
db: uniprot

uniprot P50148 82
type: UnificationXref
id: P50148
db: uniprot

uniprot Q5RKP9 85
type: UnificationXref
id: Q5RKP9
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 54

uniprot F7A632 42
type: UnificationXref
id: F7A632
db: uniprot

IP3R
type: Protein
entity reference: IP3R
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 10116 21
type: UnificationXref
id: 10116
db: ncbitaxon

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 62

Glutamate receptor, ionotropic, N-methyl D-aspartate 1b
type: ProteinReference
evidence: Evidence 165
xref: PTHR18966:SF497
xref: uniprot Q6ZM67 212
organism: Danio rerio

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: uniprot P22612 128
xref: PTHR24353:SF137
organism: Homo sapiens

ncbitaxon 10090 19
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot Q9DBC7 150
type: UnificationXref
id: Q9DBC7
db: uniprot

PANTHER Pathway P00041 1
type: UnificationXref
id: P00041
db: PANTHER Pathway

uniprot F6R7N8 103
type: UnificationXref
id: F6R7N8
db: uniprot

uniprot P27791 130
type: UnificationXref
id: P27791
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2UD13 49
xref: PTHR13715:SF52
organism: Gallus gallus

Glutamate ionotropic receptor NMDA type subunit associated protein 1
type: ProteinReference
xref: uniprot E2RNH4 174
organism: Canis lupus familiaris

mGluR5
type: Complex
component stoichiometry: mGluR5 s6 sa5 STOICHIOMETRY ID COMPLEX
component: mGluR5
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa5 229
cellular location: cytosol

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P05771 46
organism: Homo sapiens

Homer s25 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Homer
stoichiometric coefficient: 1.0

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa20 249
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uncharacterized protein
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 165
evidence: Evidence 167
evidence: Evidence 166
xref: PTHR18966:SF407
xref: uniprot A0A1D5QE40 164
organism: Macaca mulatta

G protein subunit alpha q
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot E1BA29 66
organism: Bos taurus

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot A0A1D5QG31 63
xref: PTHR10218:SF328
organism: Macaca mulatta

GluR5
type: Protein
entity reference: GluR5
feature: GluR5 s97 a116 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein kinase cAMP-activated catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H2QFK0 109
organism: Pan troglodytes

uniprot P41594 159
type: UnificationXref
id: P41594
db: uniprot

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 259
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot Q5F3B5 84
organism: Gallus gallus

ncbitaxon 9606 17
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot P51817 134
type: UnificationXref
id: P51817
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 145

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot F7A632 42
organism: Monodelphis domestica

uniprot F7G1K7 71
type: UnificationXref
id: F7G1K7
db: uniprot

uniprot P23385 157
type: UnificationXref
id: P23385
db: uniprot

uniprot K7BS10 189
type: UnificationXref
id: K7BS10
db: uniprot

GTP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

G-Protein
type: ProteinReference
xref: P01057
standard name: Gq-protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group I pathway.PROTEIN.GENERIC.G-Protein
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein G(q) subunit alpha
member entity reference: Guanine nucleotide-binding protein subunit alpha-11
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)
member entity reference: Guanine nucleotide-binding protein (G protein), q polypeptide
member entity reference: G protein subunit alpha q
member entity reference: Guanine nucleotide-binding protein subunit alpha-15
member entity reference: EGL-30
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)

Metabotropic glutamate receptor 5
type: ProteinReference
xref: uniprot Q3UVX5 162
xref: PTHR24060:SF30
organism: Mus musculus

uniprot E2QUL1 173
type: UnificationXref
id: E2QUL1
db: uniprot

PTHR24353:SF133
type: RelationshipXref
id: PTHR24353:SF133
db: PANTHER Family
relationship type: By Homology

uniprot F6VQP7 52
type: UnificationXref
id: F6VQP7
db: uniprot

NMDA
type: ProteinReference
xref: P01060
standard name: N-methyl-D-aspartate Receptor
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group I pathway.PROTEIN.ION_CHANNEL.NMDA
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES= Long Name: N-methyl-D-aspartate Receptor Synonym: Synonym not specified Accession: P01060
member entity reference: Glutamate receptor, ionotropic, N-methyl D-aspartate 1a
member entity reference: Glutamate receptor, ionotropic, N-methyl D-aspartate 1b
member entity reference: Glutamate receptor ionotropic, NMDA 1
member entity reference: Protein lifeguard 1
member entity reference: Glutamate [NMDA] receptor subunit 1
member entity reference: Glutamate receptor ionotropic, NMDA 3B
member entity reference: Glutamate ionotropic receptor NMDA type subunit 3A
member entity reference: Glutamate receptor ionotropic, NMDA 3A
member entity reference: Uncharacterized protein
member entity reference: Glutamate [NMDA] receptor subunit zeta-1 isoform NR1-3
member entity reference: AGAP001478-PA
member entity reference: Glutamate ionotropic receptor NMDA type subunit associated protein 1
member entity reference: Glutamate receptor ionotropic, NMDA 2C
member entity reference: Protein CBR-NMR-1
member entity reference: NMDA class glutamate Receptor
member entity reference: Glutamate receptor ionotropic, NMDA3A
member entity reference: Glutamate receptor ionotropic, NMDA 2A
member entity reference: GRIN2B isoform 3
member entity reference: Glutamate receptor ionotropic, NMDA 2B
member entity reference: Glutamate receptor ionotropic, NMDA 2D
member entity reference: Glutamate ionotropic receptor NMDA type subunit 1
member entity reference: Glutamate ionotropic receptor NMDA type subunit 2A
member entity reference: N-methyl-D-aspartate receptor type 1 subunit
member entity reference: N-methyl D-aspartate receptor subtype 2B

PTHR24353:SF137
type: RelationshipXref
id: PTHR24353:SF137
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF67
type: RelationshipXref
id: PTHR24353:SF67
db: PANTHER Family
relationship type: By Homology

uniprot P16912 125
type: UnificationXref
id: P16912
db: uniprot

PTHR24353:SF135
type: RelationshipXref
id: PTHR24353:SF135
db: PANTHER Family
relationship type: By Homology

uniprot F6S5B1 29
type: UnificationXref
id: F6S5B1
db: uniprot

Metabotropic glutamate receptor 1
type: ProteinReference
xref: PTHR24060:SF29
xref: uniprot Q13255 161
organism: Homo sapiens

Homer s5 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Homer
stoichiometric coefficient: 1.0

Glutamate receptor ionotropic, kainate 5
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot Q16478 36
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot P11881 56
xref: PTHR13715:SF52
organism: Mus musculus

uniprot Q24418 205
type: UnificationXref
id: Q24418
db: uniprot

Glutamate ionotropic receptor NMDA type subunit 1
type: ProteinReference
evidence: Evidence 165
xref: uniprot G3N3K3 185
xref: PTHR18966:SF377
organism: Bos taurus

GluR5 s97 a116 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.327051932306855
comment: MODIFICATION_RESIDUE_NAME=

mGluR5
type: ProteinReference
xref: P01061
standard name: Metabotropic Glutamate Receptor 5
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group I pathway.PROTEIN.RECEPTOR.mGluR5
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Metabotropic glutamate receptor 5
member entity reference: Glutamate metabotropic receptor 1
member entity reference: Metabotropic glutamate receptor 1 isoform beta
member entity reference: Metabotropic glutamate receptor 1
member entity reference: Metabotropic glutamate receptor 5 isoform a
member entity reference: Glutamate metabotropic receptor 5
member entity reference: Uncharacterized protein

Glutamate receptor ionotropic, kainate 1
type: ProteinReference
xref: uniprot P39086 35
xref: PTHR18966:SF36
organism: Homo sapiens

uniprot F6VTB5 181
type: UnificationXref
id: F6VTB5
db: uniprot

uniprot E2RNH4 174
type: UnificationXref
id: E2RNH4
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot F6THW2 69
organism: Xenopus tropicalis

uniprot A0A2I3SSC7 48
type: UnificationXref
id: A0A2I3SSC7
db: uniprot

PARTICIPANT STOICHIOMETRY r59 300
type: Stoichiometry
physical entity: mGluR5
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 301
type: Stoichiometry
physical entity: Complex (G-Protein/GDP)
stoichiometric coefficient: 1.0

uniprot F1QJL5 68
type: UnificationXref
id: F1QJL5
db: uniprot

uniprot H2QXB9 110
type: UnificationXref
id: H2QXB9
db: uniprot

uniprot O15399 190
type: UnificationXref
id: O15399
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

Glutamate receptor ionotropic, kainate 1
type: ProteinReference
xref: PTHR18966:SF36
xref: uniprot Q60934 38
organism: Mus musculus

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

uniprot A9JTQ6 89
type: UnificationXref
id: A9JTQ6
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot Q91UZ1 18
xref: PTHR10336:SF106
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r59 302
type: Stoichiometry
physical entity: Complex (mGluR1/mGluR5/ Homer/G-Protein/ GDP)
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r52
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 279
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 278
left: PKC
interaction type: STATE_TRANSITION
right: PKC

uniprot F6SR09 153
type: UnificationXref
id: F6SR09
db: uniprot

uniprot Q86YM7 93
type: UnificationXref
id: Q86YM7
db: uniprot

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot P00514 115
xref: PTHR11635:SF129
organism: Bos taurus

PTHR24353:SF128
type: RelationshipXref
id: PTHR24353:SF128
db: PANTHER Family
relationship type: By Homology

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P00517 116
xref: PTHR24353:SF82
organism: Bos taurus

uniprot P30678 78
type: UnificationXref
id: P30678
db: uniprot

PTHR24353:SF82
type: RelationshipXref
id: PTHR24353:SF82
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F7AGW3 30
xref: PTHR18966:SF36
organism: Macaca mulatta

uniprot F7H6T2 108
type: UnificationXref
id: F7H6T2
db: uniprot

PKA
type: ProteinReference
xref: P01059
standard name: Protein kinase A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group I pathway.PROTEIN.GENERIC.PKA
comment: ENTITY_REFERENCE_NOTES= Long Name: Protein Kinase A Synonym: PKA Accession: P01059
member entity reference: cAMP-dependent protein kinase regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha
member entity reference: Protein kinase A catalytic subunit isoform 2
member entity reference: cAMP-dependent protein kinase catalytic subunit gamma
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha isoform 1
member entity reference: Protein kinase, cAMP-dependent, regulatory, type I, beta
member entity reference: Prkar1a protein
member entity reference: AGAP001384-PA
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
member entity reference: cAMP-dependent protein kinase catalytic subunit beta
member entity reference: Uncharacterized protein
member entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit PRKX
member entity reference: AGAP008039-PA (Fragment)
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta
member entity reference: PRKACG isoform 1
member entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit
member entity reference: Protein kinase A catalytic subunit isoform 1
member entity reference: Protein kinase A catalytic subunit
member entity reference: cAMP-dependent protein kinase type I regulatory subunit
member entity reference: Protein kinase, X-linked
member entity reference: Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
member entity reference: cAMP-dependent protein kinase catalytic subunit 3
member entity reference: Protein kinase cAMP-activated catalytic subunit alpha
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta a
member entity reference: cAMP-dependent protein kinase catalytic subunit 1
member entity reference: PRKACB isoform 3
member entity reference: PRKAR1A isoform 12
member entity reference: Protein kinase cAMP-activated catalytic subunit beta
member entity reference: Protein kinase cAMP-dependent type I regulatory subunit alpha
member entity reference: cAMP-dependent protein kinase catalytic subunit beta isoform 1

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot F7G1K7 71
organism: Monodelphis domestica

G Protein s17 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

uniprot A0A1D5QE40 164
type: UnificationXref
id: A0A1D5QE40
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 11

uniprot Q60934 38
type: UnificationXref
id: Q60934
db: uniprot

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot Q62645 209
type: UnificationXref
id: Q62645
db: uniprot

uniprot P68404 47
type: UnificationXref
id: P68404
db: uniprot

uniprot P00514 115
type: UnificationXref
id: P00514
db: uniprot

uniprot Q63273 40
type: UnificationXref
id: Q63273
db: uniprot

Glutamate receptor ionotropic, NMDA 2A
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 165
evidence: Evidence 167
evidence: Evidence 166
xref: PTHR18966:SF407
xref: uniprot P35436 192
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5PCI4 95
xref: PTHR11635:SF126
organism: Gallus gallus

uniprot Q61626 39
type: UnificationXref
id: Q61626
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P05987 119
organism: Dictyostelium discoideum

uniprot A0A2I3T5R2 88
type: UnificationXref
id: A0A2I3T5R2
db: uniprot

PTHR24353:SF117
type: RelationshipXref
id: PTHR24353:SF117
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3S1J9 24
type: UnificationXref
id: A0A2I3S1J9
db: uniprot

uniprot A2VE57 26
type: UnificationXref
id: A2VE57
db: uniprot

PTHR24353:SF116
type: RelationshipXref
id: PTHR24353:SF116
db: PANTHER Family
relationship type: By Homology

uniprot H2QZZ2 188
type: UnificationXref
id: H2QZZ2
db: uniprot

PTHR24353:SF37
type: RelationshipXref
id: PTHR24353:SF37
db: PANTHER Family
relationship type: By Homology

uniprot Q7PXM3 213
type: UnificationXref
id: Q7PXM3
db: uniprot

uniprot Q5F3B5 84
type: UnificationXref
id: Q5F3B5
db: uniprot

uniprot H2R1G3 111
type: UnificationXref
id: H2R1G3
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05126 45
xref: PTHR24356:SF158
organism: Bos taurus

NMDA
type: Protein
entity reference: NMDA
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa24 237
feature: NMDA s32 sa24 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 165
xref: PTHR18966:SF382
xref: uniprot Q13224 203
organism: Homo sapiens

uniprot A2AIR5 169
type: UnificationXref
id: A2AIR5
db: uniprot

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
type: ProteinReference
xref: uniprot A3KMS9 96
xref: PTHR24353:SF82
organism: Danio rerio

uniprot P05131 117
type: UnificationXref
id: P05131
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF128
xref: uniprot H2RI77 113
organism: Pan troglodytes

uniprot Q32L53 206
type: UnificationXref
id: Q32L53
db: uniprot

Complex (NMDA/Glutamate)
type: Complex
component stoichiometry: Glutamate s33 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: NMDA s32 sa24 STOICHIOMETRY ID COMPLEX
component: NMDA
component: Glutamate
feature: COMPLEX BINDING FEATURE s100 a118 236
feature: COMPLEX BINDING FEATURE s100 a118 238
cellular location: cytosol

uniprot F1NWG3 152
type: UnificationXref
id: F1NWG3
db: uniprot

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 165
xref: PTHR18966:SF377
xref: uniprot Q05586 201
organism: Homo sapiens

Homer scaffold protein 1
type: ProteinReference
xref: uniprot A9JTQ6 89
xref: PTHR10918:SF3
organism: Xenopus tropicalis

uniprot Q5R1P0 207
type: UnificationXref
id: Q5R1P0
db: uniprot

mGluR1
type: ProteinReference
xref: P01062
standard name: Metabotropic Glutamate Receptor 1
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group I pathway.PROTEIN.RECEPTOR.mGluR1
comment: ENTITY_REFERENCE_NOTES= Long Name: Metabotropic glutamate receptor 1 Synonym: mGlu 1,mGlu1,mGluR1 Accession: P01062
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Metabotropic glutamate receptor 5
member entity reference: Glutamate metabotropic receptor 1
member entity reference: Metabotropic glutamate receptor 1 isoform beta
member entity reference: Metabotropic glutamate receptor 1
member entity reference: Metabotropic glutamate receptor 5 isoform a
member entity reference: Glutamate metabotropic receptor 5
member entity reference: Uncharacterized protein

uniprot P29994 57
type: UnificationXref
id: P29994
db: uniprot

Homer
type: Protein
entity reference: Homer
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7GR67 184
type: UnificationXref
id: F7GR67
db: uniprot

mGluR5
type: Protein
entity reference: mGluR5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GDP s31 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot Q9Y0A1 61
type: UnificationXref
id: Q9Y0A1
db: uniprot

DISSOCIATION
type: InteractionVocabulary

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa22 253
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Homer protein homolog 1
type: ProteinReference
xref: PTHR10918:SF3
xref: uniprot Q2KJ56 92
organism: Bos taurus

DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 303
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 305
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 304
left: PIP2
interaction type: DISSOCIATION
right: IP3
right: DAG

uniprot F7CS79 183
type: UnificationXref
id: F7CS79
db: uniprot

Glutamate receptor ionotropic, NMDA 3B
type: ProteinReference
evidence: Evidence 165
evidence: Evidence 170
xref: uniprot Q91ZU9 217
xref: PTHR18966:SF364
organism: Mus musculus

Glutamate ionotropic receptor NMDA type subunit associated protein 1
type: ProteinReference
xref: uniprot K7BS10 189
organism: Pan troglodytes

Glutamate ionotropic receptor kainate type subunit 5
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot A0A2I3S1J9 24
organism: Pan troglodytes

uniprot H2Q5I0 187
type: UnificationXref
id: H2Q5I0
db: uniprot

uniprot E9AFM1 98
type: UnificationXref
id: E9AFM1
db: uniprot

Inositol 1,4,5-trisphosphate receptor itr-1
type: ProteinReference
xref: uniprot Q9Y0A1 61
xref: PTHR13715:SF87
organism: Caenorhabditis elegans

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P05132 118
xref: PTHR24353:SF82
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P05131 117
xref: PTHR24353:SF116
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r52 279
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

NMDA
type: Protein
entity reference: NMDA
feature: NMDA s98 a114 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR13715:SF52
type: RelationshipXref
id: PTHR13715:SF52
db: PANTHER Family
relationship type: By Homology

mGluR5
type: Protein
entity reference: mGluR5
feature: COMPLEX PARTICIPANT BINDING FEATURE s104 sa10 263
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Glutamate receptor, ionotropic, kainate 5
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot Q2HJD2 37
organism: Bos taurus

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot P38409 81
organism: Bos taurus

mGluR5
type: Protein
entity reference: mGluR5

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 17

uniprot P97772 160
type: UnificationXref
id: P97772
db: uniprot

uniprot Q15147 16
type: UnificationXref
id: Q15147
db: uniprot

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 165
xref: uniprot Q00960 196
xref: PTHR18966:SF382
organism: Rattus norvegicus

Glutamate receptor ionotropic, NMDA 2C
type: ProteinReference
evidence: Evidence 165
evidence: Evidence 166
xref: uniprot Q00961 197
xref: PTHR18966:SF361
organism: Rattus norvegicus

uniprot Q8TCU5 215
type: UnificationXref
id: Q8TCU5
db: uniprot

PTHR11635:SF152
type: RelationshipXref
id: PTHR11635:SF152
db: PANTHER Family
relationship type: By Homology

uniprot E9GNI4 100
type: UnificationXref
id: E9GNI4
db: uniprot

PKA
type: Protein
entity reference: PKA
feature: ACTIVE 22
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Glutamate ionotropic receptor NMDA type subunit 3A
type: ProteinReference
evidence: Evidence 165
evidence: Evidence 170
xref: PTHR18966:SF397
xref: uniprot H2QZZ2 188
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF217
xref: uniprot F1N2V3 67
organism: Bos taurus

uniprot P12370 122
type: UnificationXref
id: P12370
db: uniprot

GDP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

cAMP-dependent protein kinase catalytic subunit alpha isoform 1
type: ProteinReference
xref: uniprot H9EQQ4 114
xref: PTHR24353:SF82
organism: Macaca mulatta

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot F1MX21 50
xref: PTHR13715:SF52
organism: Bos taurus

uniprot Q5I0F6 141
type: UnificationXref
id: Q5I0F6
db: uniprot

STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r63
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 288
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 289
left: IP3R
interaction type: STATE_TRANSITION
right: IP3R

PARTICIPANT STOICHIOMETRY r52 278
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

uniprot Q7PXF7 144
type: UnificationXref
id: Q7PXF7
db: uniprot

STATE_TRANSITION_LEFT__NMDA-_Glutamate-RIGHT__Complex__NMDA_Glutamate_-_r66
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 286
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 287
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 285
left: Glutamate
left: NMDA
interaction type: STATE_TRANSITION
right: Complex (NMDA/Glutamate)

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P22694 129
xref: PTHR24353:SF116
organism: Homo sapiens

Glutamate receptor ionotropic, NMDA 2A
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 165
evidence: Evidence 167
evidence: Evidence 166
xref: PTHR18966:SF407
xref: uniprot Q00959 195
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot P29992 77
xref: PTHR10218:SF328
organism: Homo sapiens

Glutamate metabotropic receptor 5
type: ProteinReference
xref: uniprot J9JH96 156
xref: PTHR24060:SF30
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r66 285
type: Stoichiometry
physical entity: NMDA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r66 286
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Glutamate [NMDA] receptor subunit zeta-1 isoform NR1-3
type: ProteinReference
evidence: Evidence 165
xref: PTHR18966:SF377
xref: uniprot F7GR67 184
organism: Macaca mulatta

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot P29994 57
xref: PTHR13715:SF52
organism: Rattus norvegicus

Ca2+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

uniprot Q08C49 137
type: UnificationXref
id: Q08C49
db: uniprot

uniprot A0A1D5PHB3 23
type: UnificationXref
id: A0A1D5PHB3
db: uniprot

Complex (GluR5/Glutamate)
type: Complex
component stoichiometry: GluR5 s34 sa26 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glutamate s35 sa27 STOICHIOMETRY ID COMPLEX
component: Glutamate
component: GluR5
feature: COMPLEX BINDING FEATURE s103 a123 242
feature: COMPLEX BINDING FEATURE s103 a123 240
cellular location: cytosol

uniprot Q91UZ1 18
type: UnificationXref
id: Q91UZ1
db: uniprot

uniprot F6VHF7 51
type: UnificationXref
id: F6VHF7
db: uniprot

G protein subunit alpha q
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot K6ZCJ5 73
organism: Pan troglodytes

Danio rerio
type: BioSource
xref: ncbitaxon 7955 65

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa7 233
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P16905 124
type: UnificationXref
id: P16905
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot Q8MJ44 148
xref: PTHR24353:SF82
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot E9GNI4 100
organism: Daphnia pulex

mGluR1
type: Complex
component stoichiometry: mGluR1 s3 sa3 STOICHIOMETRY ID COMPLEX
component: mGluR1
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 271
cellular location: cytosol

ncbitaxon 7165 145
type: UnificationXref
id: 7165
db: ncbitaxon

Guanine nucleotide-binding protein (G protein), q polypeptide
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot B8JLJ7 64
organism: Danio rerio

mGluR1 s26 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR1
stoichiometric coefficient: 1.0

GluR5 s34 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GluR5
stoichiometric coefficient: 1.0

uniprot A8XW88 97
type: UnificationXref
id: A8XW88
db: uniprot

uniprot Q27687 138
type: UnificationXref
id: Q27687
db: uniprot

mGluR5 s23 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR5
stoichiometric coefficient: 1.0

uniprot Q6P6R0 210
type: UnificationXref
id: Q6P6R0
db: uniprot

PARTICIPANT STOICHIOMETRY r66 287
type: Stoichiometry
physical entity: Complex (NMDA/Glutamate)
stoichiometric coefficient: 1.0

uniprot P35438 193
type: UnificationXref
id: P35438
db: uniprot

AGAP001384-PA
type: ProteinReference
xref: uniprot Q7PXF7 144
xref: PTHR24353:SF117
organism: Anopheles gambiae

uniprot F6TQN3 10
type: UnificationXref
id: F6TQN3
db: uniprot

IP3R
type: Protein
entity reference: IP3R
feature: ACTIVE 22
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot P05126 45
type: UnificationXref
id: P05126
db: uniprot

uniprot A0A1D5QG31 63
type: UnificationXref
id: A0A1D5QG31
db: uniprot

uniprot A3KMS9 96
type: UnificationXref
id: A3KMS9
db: uniprot

uniprot Q6DBV8 143
type: UnificationXref
id: Q6DBV8
db: uniprot

Homer
type: Protein
entity reference: Homer
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa11 265
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P35439 194
type: UnificationXref
id: P35439
db: uniprot

Ca2+
type: SmallMolecule
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=ION

GDP s9 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot H8WGV2 53
type: UnificationXref
id: H8WGV2
db: uniprot

eco ECO:0000305 79
type: UnificationXref
id: ECO:0000305
db: eco

Uncharacterized protein
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 165
xref: PTHR18966:SF382
xref: uniprot F6PGX6 179
organism: Monodelphis domestica

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa8 235
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Protein lifeguard 1
type: ProteinReference
xref: uniprot Q32L53 206
organism: Bos taurus

uniprot H2QAS6 44
type: UnificationXref
id: H2QAS6
db: uniprot

G Protein s30 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

uniprot F7ECA6 70
type: UnificationXref
id: F7ECA6
db: uniprot

PARTICIPANT STOICHIOMETRY r63 289
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r63 288
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

mGluR1
type: Protein
entity reference: mGluR1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r22
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 281
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 280
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 120

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

…
type: Stoichiometry
physical entity: mGluR1
stoichiometric coefficient: 2.0

mGluR1 s22 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR1
stoichiometric coefficient: 1.0

Glutamate ionotropic receptor NMDA type subunit 1
type: ProteinReference
evidence: Evidence 165
xref: PTHR18966:SF377
xref: uniprot F7CS79 183
organism: Xenopus tropicalis

uniprot F6WM87 105
type: UnificationXref
id: F6WM87
db: uniprot

uniprot P30679 80
type: UnificationXref
id: P30679
db: uniprot

PTHR11635:SF129
type: RelationshipXref
id: PTHR11635:SF129
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF126
type: RelationshipXref
id: PTHR11635:SF126
db: PANTHER Family
relationship type: By Homology

mGluR5
type: Protein
entity reference: mGluR5
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa15 223
feature: ACTIVE 22
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 79

uniprot Q3ZB92 139
type: UnificationXref
id: Q3ZB92
db: uniprot

PLC
type: ProteinReference
xref: P01053
standard name: Phospholipase C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Metabotropic glutamate receptor group I pathway.PROTEIN.GENERIC.PLC
comment: ENTITY_REFERENCE_NOTES= Long Name: Phospholipase C Synonym: PLC Accession: P01053
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q15147 16
organism: Homo sapiens

uniprot A0A1D5PU34 87
type: UnificationXref
id: A0A1D5PU34
db: uniprot

Protein lifeguard 1
type: ProteinReference
xref: uniprot Q9ESF4 218
organism: Mus musculus

uniprot P05771 46
type: UnificationXref
id: P05771
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NMDA-_Glutamate-RIGHT__Complex__NMDA_Glutamate_-_r66
controller: PKC

uniprot Q14957 204
type: UnificationXref
id: Q14957
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r22
control type: ACTIVATION
controller: IP3R

ncbitaxon 7955 65
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot A8KBH6 41
type: UnificationXref
id: A8KBH6
db: uniprot

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r8
controller: PLC

PKC
type: Protein
entity reference: PKC
feature: ACTIVE 22
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Glutamate receptor ionotropic, kainate 5
type: ProteinReference
xref: PTHR18966:SF351
xref: uniprot Q61626 39
organism: Mus musculus

EGL-30
type: ProteinReference
xref: PTHR10218:SF329
xref: uniprot G5EGU1 72
organism: Caenorhabditis elegans

uniprot Q9JID2 86
type: UnificationXref
id: Q9JID2
db: uniprot

uniprot P22612 128
type: UnificationXref
id: P22612
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 21

uniprot Q6R6I2 211
type: UnificationXref
id: Q6R6I2
db: uniprot

PARTICIPANT STOICHIOMETRY r8 303
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

Glutamate receptor ionotropic, NMDA 2C
type: ProteinReference
evidence: Evidence 165
evidence: Evidence 166
xref: uniprot Q14957 204
xref: PTHR18966:SF361
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r8 305
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 304
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

uniprot F7HPP3 33
type: UnificationXref
id: F7HPP3
db: uniprot

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 101

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot Q9DBC7 150
xref: PTHR11635:SF129
organism: Mus musculus

uniprot Q5R1P3 208
type: UnificationXref
id: Q5R1P3
db: uniprot

Protein kinase A catalytic subunit isoform 2
type: ProteinReference
xref: uniprot E9AFM1 98
xref: PTHR24353:SF67
organism: Leishmania major

uniprot Q24498 59
type: UnificationXref
id: Q24498
db: uniprot

DISSOCIATION_LEFT__GTP-_Complex__mGluR1_mGluR5__Glutamate_Homer__G_Protein_GDP_-RIGHT__Complex__GTP_G_Protein_-_Complex__mGluR1_mGluR5__Glutamate_Homer_-_GDP-_r62
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 293
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 292
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 294
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 290
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 291
left: GTP
left: Complex (mGluR1/mGluR5/ Glutamate/Homer/ G-Protein/GDP)
interaction type: DISSOCIATION
right: Complex (GTP/G-Protein)
right: Complex (mGluR1/mGluR5/ Glutamate/Homer)
right: GDP

HETERODIMER_ASSOCIATION_LEFT__Complex__mGluR1_mGluR5__Homer_G_Protein__GDP_-_Glutamate-RIGHT__Complex__mGluR1_mGluR5__Glutamate_Homer__G_Protein_GDP_-_r61
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 295
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 296
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 297
left: Glutamate
left: Complex (mGluR1/mGluR5/ Homer/G-Protein/ GDP)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (mGluR1/mGluR5/ Glutamate/Homer/ G-Protein/GDP)

Complex (mGluR1/mGluR5/ Homer/G-Protein/ GDP)
type: Complex
component stoichiometry: mGluR5 s104 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: Homer s12 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s17 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s21 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: mGluR1 s10 sa9 STOICHIOMETRY ID COMPLEX
component: mGluR1
component: G-Protein
component: Homer
component: GDP
component: mGluR5
feature: COMPLEX BINDING FEATURE s77 a90 266
feature: COMPLEX BINDING FEATURE s77 a90 268
feature: COMPLEX BINDING FEATURE s77 a90 260
feature: COMPLEX BINDING FEATURE s77 a90 262
feature: COMPLEX BINDING FEATURE s77 a90 264
cellular location: cytosol

uniprot H9EQQ4 114
type: UnificationXref
id: H9EQQ4
db: uniprot

PARTICIPANT STOICHIOMETRY r58 308
type: Stoichiometry
physical entity: Complex (mGluR5/Homer)
stoichiometric coefficient: 1.0

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa16 225
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r58 307
type: Stoichiometry
physical entity: mGluR5
stoichiometric coefficient: 1.0

uniprot Q7Z429 214
type: UnificationXref
id: Q7Z429
db: uniprot

PARTICIPANT STOICHIOMETRY r58 306
type: Stoichiometry
physical entity: Homer
stoichiometric coefficient: 1.0

uniprot H9FU38 55
type: UnificationXref
id: H9FU38
db: uniprot

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 165
xref: PTHR18966:SF377
xref: uniprot P35438 193
organism: Mus musculus

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 165
xref: PTHR18966:SF377
xref: uniprot P35439 194
organism: Rattus norvegicus

ncbitaxon 9031 5
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot P10644 121
type: UnificationXref
id: P10644
db: uniprot

ncbitaxon 6239 62
type: UnificationXref
id: 6239
db: ncbitaxon

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot H9FVW1 14
xref: PTHR10336:SF106
organism: Macaca mulatta

STATE_TRANSITION
type: InteractionVocabulary

GRIN2B isoform 3
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 165
xref: PTHR18966:SF382
xref: uniprot H2Q5I0 187
organism: Pan troglodytes

ncbitaxon 9544 15
type: UnificationXref
id: 9544
db: ncbitaxon

ACTIVE 22
type: EntityFeature
comment: Active state

TRANSPORT
type: InteractionVocabulary

PKC
type: Protein
entity reference: PKC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GRIK1 protein
type: ProteinReference
xref: uniprot A2VE57 26
organism: Bos taurus

NMDA s32 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NMDA
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G4Q0 107
xref: PTHR24353:SF82
organism: Monodelphis domestica

PRKACG isoform 1
type: ProteinReference
xref: uniprot H2QXB9 110
xref: PTHR24353:SF137
organism: Pan troglodytes

uniprot Q91ZU9 217
type: UnificationXref
id: Q91ZU9
db: uniprot

uniprot F7BDN8 31
type: UnificationXref
id: F7BDN8
db: uniprot

Complex (mGluR5/Homer)
type: Complex
component stoichiometry: Homer s7 sa6 STOICHIOMETRY ID COMPLEX
component: mGluR5
component: Homer
feature: COMPLEX BINDING FEATURE s70 a80 228
feature: COMPLEX BINDING FEATURE s70 a80 230
cellular location: cytosol

PARTICIPANT STOICHIOMETRY r53 277
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 276
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot A8KBH6 41
organism: Xenopus tropicalis

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 165
xref: PTHR18966:SF377
xref: uniprot Q5R1P0 207
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r52
controller: DAG

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 168
evidence: Evidence 165
xref: PTHR18966:SF382
xref: uniprot Q5R1P3 208
organism: Canis lupus familiaris

Complex (GTP/G-Protein)
type: Complex
component stoichiometry: GTP s1 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s2 sa2 STOICHIOMETRY ID COMPLEX
component: GTP
component: G-Protein
feature: COMPLEX BINDING FEATURE s59 a65 256
feature: COMPLEX BINDING FEATURE s59 a65 258
feature: ACTIVE 22
cellular location: cytosol

uniprot E2RT37 90
type: UnificationXref
id: E2RT37
db: uniprot

uniprot P17612 126
type: UnificationXref
id: P17612
db: uniprot

uniprot F7HNK9 91
type: UnificationXref
id: F7HNK9
db: uniprot

uniprot P05132 118
type: UnificationXref
id: P05132
db: uniprot

NMDA class glutamate Receptor
type: ProteinReference
evidence: Evidence 165
xref: PTHR18966:SF377
xref: uniprot G5EGQ9 186
organism: Caenorhabditis elegans

Leishmania major
type: BioSource
xref: ncbitaxon 5664 99

Homer scaffold protein 1
type: ProteinReference
xref: uniprot A0A2I3T5R2 88
xref: PTHR10918:SF3
organism: Pan troglodytes

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa23 255
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

uniprot F6YLB3 182
type: UnificationXref
id: F6YLB3
db: uniprot

uniprot P35436 192
type: UnificationXref
id: P35436
db: uniprot

uniprot P34099 133
type: UnificationXref
id: P34099
db: uniprot

PLC
type: Protein
entity reference: PLC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Ryanodine receptor
type: ProteinReference
xref: uniprot Q24498 59
organism: Drosophila melanogaster

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot F7BYI4 43
organism: Macaca mulatta

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot P34099 133
xref: PTHR24353:SF37
organism: Dictyostelium discoideum

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot A0A3Q2U0G2 4
type: UnificationXref
id: A0A3Q2U0G2
db: uniprot

ncbitaxon 5664 99
type: UnificationXref
id: 5664
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r62 294
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Glutamate receptor ionotropic, NMDA 2D
type: ProteinReference
evidence: Evidence 165
evidence: Evidence 191
evidence: Evidence 166
xref: uniprot Q03391 200
xref: PTHR18966:SF385
organism: Mus musculus

Guanine nucleotide-binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1
type: ProteinReference
xref: PTHR10218:SF217
xref: uniprot F1QJL5 68
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r62 292
type: Stoichiometry
physical entity: Complex (GTP/G-Protein)
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot H2QJY5 12
xref: PTHR10336:SF106
organism: Pan troglodytes

cAMP-dependent protein kinase catalytic subunit 3
type: ProteinReference
xref: uniprot P16912 125
xref: PTHR24353:SF37
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r62 293
type: Stoichiometry
physical entity: Complex (mGluR1/mGluR5/ Glutamate/Homer)
stoichiometric coefficient: 1.0

uniprot P12849 123
type: UnificationXref
id: P12849
db: uniprot

PARTICIPANT STOICHIOMETRY r62 290
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r62 291
type: Stoichiometry
physical entity: Complex (mGluR1/mGluR5/ Glutamate/Homer/ G-Protein/GDP)
stoichiometric coefficient: 1.0

uniprot H2QFK0 109
type: UnificationXref
id: H2QFK0
db: uniprot

GO GO:0005783 3
type: UnificationXref
id: GO:0005783
db: GO

uniprot F1PLB3 8
type: UnificationXref
id: F1PLB3
db: uniprot

uniprot F7BYI4 43
type: UnificationXref
id: F7BYI4
db: uniprot

mGluR1 s10 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR1
stoichiometric coefficient: 1.0

mGluR1
type: Protein
entity reference: mGluR1
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa18 245
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

cAMP-dependent protein kinase type I regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P16905 124
organism: Drosophila melanogaster

Protein kinase, cAMP-dependent, catalytic, beta
type: ProteinReference
xref: uniprot Q3ZB92 139
xref: PTHR24353:SF116
organism: Danio rerio

cAMP-dependent protein kinase catalytic subunit beta isoform 1
type: ProteinReference
xref: uniprot F7EBQ5 106
xref: PTHR24353:SF116
organism: Macaca mulatta

AGAP001478-PA
type: ProteinReference
evidence: Evidence 165
xref: PTHR18966:SF377
xref: uniprot Q7PXM3 213
organism: Anopheles gambiae

mGluR5 s6 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR5
stoichiometric coefficient: 2.0

uniprot Q3UVX5 162
type: UnificationXref
id: Q3UVX5
db: uniprot

Protein kinase A catalytic subunit isoform 1
type: ProteinReference
xref: PTHR24353:SF67
xref: uniprot Q9GNR4 151
organism: Leishmania major