uniprot F7BYI4 480
type: UnificationXref
id: F7BYI4
db: uniprot

Neuronal synaptobrevin, isoform J
type: ProteinReference
xref: PTHR45701:SF3
xref: uniprot M9PE71 98
organism: Drosophila melanogaster

TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_r78
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 580
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 579
left: K+
interaction type: TRANSPORT
right: K+

uniprot A0A2I3SR99 73
type: UnificationXref
id: A0A2I3SR99
db: uniprot

uniprot H2RAF8 19
type: UnificationXref
id: H2RAF8
db: uniprot

PTHR24356:SF303
type: RelationshipXref
id: PTHR24356:SF303
db: PANTHER Family
relationship type: By Homology

uniprot F1R506 472
type: UnificationXref
id: F1R506
db: uniprot

uniprot Q0V7N0 129
type: UnificationXref
id: Q0V7N0
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q5ZJ03 421
organism: Gallus gallus

PTHR24356:SF170
type: RelationshipXref
id: PTHR24356:SF170
db: PANTHER Family
relationship type: By Homology

uniprot P09215 499
type: UnificationXref
id: P09215
db: uniprot

ACh
type: SmallMolecule
cellular location: synaptic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot B7Q3T6 289
type: UnificationXref
id: B7Q3T6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IFL6 284
organism: Bos taurus

uniprot H2QNP1 174
type: UnificationXref
id: H2QNP1
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RBE7 300
organism: Canis lupus familiaris

choline
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa11 566
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CAT
type: ProteinReference
xref: P01063
standard name: choline acetyltransferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 1 and 3 signaling pathway.PROTEIN.GENERIC.CAT
comment: ENTITY_REFERENCE_NOTES= Long Name: choline acetyltransferase Synonym: CAT,CHAT Accession: P01063
member entity reference: Choline O-acetyltransferase
member entity reference: Uncharacterized protein
member entity reference: AGAP002370-PA (Fragment)
member entity reference: Protein CBR-CHA-1
member entity reference: CHAT isoform 7

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF347
xref: uniprot A8WR64 460
organism: Caenorhabditis briggsae

Mus musculus
type: BioSource
xref: ncbitaxon 10090 30

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot F6XYX9 86
organism: Monodelphis domestica

PTHR24356:SF181
type: RelationshipXref
id: PTHR24356:SF181
db: PANTHER Family
relationship type: By Homology

uniprot F1MDC9 467
type: UnificationXref
id: F1MDC9
db: uniprot

Protein kinase C-like 3
type: ProteinReference
xref: PTHR24356:SF303
xref: uniprot Q19266 532
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot Q5RKP9 419
organism: Danio rerio

uniprot Q61017 424
type: UnificationXref
id: Q61017
db: uniprot

uniprot Q28H40 412
type: UnificationXref
id: Q28H40
db: uniprot

uniprot C3ZD75 167
type: UnificationXref
id: C3ZD75
db: uniprot

uniprot Q9Z2P6 162
type: UnificationXref
id: Q9Z2P6
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 396
organism: Homo sapiens

PTHR19305:SF14
type: RelationshipXref
id: PTHR19305:SF14
db: PANTHER Family
relationship type: By Homology

uniprot P63024 122
type: UnificationXref
id: P63024
db: uniprot

NMDA s96 a100 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.27

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 395
organism: Mus musculus

PTHR24356:SF322
type: RelationshipXref
id: PTHR24356:SF322
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 393
organism: Canis lupus familiaris

choline
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 394
organism: Homo sapiens

N-methyl D-aspartate receptor subtype 2B
type: ProteinReference
evidence: Evidence 213
evidence: Evidence 216
xref: PTHR18966:SF382
xref: uniprot F6T8S6 227
organism: Macaca mulatta

PTHR24356:SF192
type: RelationshipXref
id: PTHR24356:SF192
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot P62881 398
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 397
organism: Mus musculus

uniprot F5HMB9 189
type: UnificationXref
id: F5HMB9
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot Q14643 59
organism: Homo sapiens

uniprot H2R3A6 352
type: UnificationXref
id: H2R3A6
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot F6UFJ7 81
xref: PTHR19305:SF9
organism: Macaca mulatta

PTHR10218:SF316
type: RelationshipXref
id: PTHR10218:SF316
db: PANTHER Family
relationship type: By Homology

Glutamate ionotropic receptor NMDA type subunit 2A
type: ProteinReference
evidence: Evidence 214
evidence: Evidence 213
evidence: Evidence 215
evidence: Evidence 216
xref: uniprot F1PXS6 225
xref: PTHR18966:SF407
organism: Canis lupus familiaris

PTHR24356:SF193
type: RelationshipXref
id: PTHR24356:SF193
db: PANTHER Family
relationship type: By Homology

uniprot Q6TH03 433
type: UnificationXref
id: Q6TH03
db: uniprot

uniprot P60878 115
type: UnificationXref
id: P60878
db: uniprot

uniprot P62873 394
type: UnificationXref
id: P62873
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 314

PTHR24356:SF318
type: RelationshipXref
id: PTHR24356:SF318
db: PANTHER Family
relationship type: By Homology

uniprot F6TQN3 190
type: UnificationXref
id: F6TQN3
db: uniprot

Choline O-acetyltransferase
type: ProteinReference
xref: PTHR22589:SF14
xref: uniprot P07668 21
organism: Drosophila melanogaster

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa4 550
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7CFG8 327
type: UnificationXref
id: F7CFG8
db: uniprot

uniprot Q9S7P9 157
type: UnificationXref
id: Q9S7P9
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 392
organism: Bos taurus

uniprot Q9W1I8 160
type: UnificationXref
id: Q9W1I8
db: uniprot

uniprot O95837 359
type: UnificationXref
id: O95837
db: uniprot

uniprot F7EP58 91
type: UnificationXref
id: F7EP58
db: uniprot

uniprot P18851 363
type: UnificationXref
id: P18851
db: uniprot

K+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

ncbitaxon 6669 305
type: UnificationXref
id: 6669
db: ncbitaxon

PTHR10218:SF328
type: RelationshipXref
id: PTHR10218:SF328
db: PANTHER Family
relationship type: By Homology

High-affinity choline transporter 1
type: ProteinReference
xref: uniprot O02228 271
organism: Caenorhabditis elegans

PTHR10218:SF329
type: RelationshipXref
id: PTHR10218:SF329
db: PANTHER Family
relationship type: By Homology

uniprot P32851 111
type: UnificationXref
id: P32851
db: uniprot

PTHR24356:SF347
type: RelationshipXref
id: PTHR24356:SF347
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot F7CTP1 328
organism: Macaca mulatta

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60879 116
organism: Mus musculus

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60878 115
organism: Gallus gallus

Choline O-acetyltransferase
type: ProteinReference
xref: uniprot F1PR75 15
xref: PTHR22589:SF14
organism: Canis lupus familiaris

uniprot P29993 53
type: UnificationXref
id: P29993
db: uniprot

uniprot F1P1X4 40
type: UnificationXref
id: F1P1X4
db: uniprot

uniprot F1NMB0 224
type: UnificationXref
id: F1NMB0
db: uniprot

Putative synaptobrevin homologue SNC1/2 (Eurofung)
type: ProteinReference
xref: uniprot Q5ASG1 140
organism: Emericella nidulans

Serine/threonine-protein kinase N
type: ProteinReference
xref: uniprot A1Z7T0 457
xref: PTHR24356:SF210
organism: Drosophila melanogaster

Guanine nucleotide binding protein, beta 3
type: ProteinReference
xref: uniprot Q5XGD8 420
organism: Xenopus tropicalis

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60877 114
organism: Macaca mulatta

uniprot Q7QCP8 541
type: UnificationXref
id: Q7QCP8
db: uniprot

uniprot Q12879 252
type: UnificationXref
id: Q12879
db: uniprot

PARTICIPANT STOICHIOMETRY r72 596
type: Stoichiometry
physical entity: choline
stoichiometric coefficient: 1.0

uniprot Q7QFG0 183
type: UnificationXref
id: Q7QFG0
db: uniprot

PARTICIPANT STOICHIOMETRY r72 595
type: Stoichiometry
physical entity: Complex (CHT1/choline)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r72 597
type: Stoichiometry
physical entity: CHT1
stoichiometric coefficient: 1.0

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60880 117
organism: Homo sapiens

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 20

uniprot P63217 404
type: UnificationXref
id: P63217
db: uniprot

uniprot E1BWA3 463
type: UnificationXref
id: E1BWA3
db: uniprot

Protein CBR-CHO-1
type: ProteinReference
xref: uniprot A8WQR8 268
xref: PTHR45897:SF4
organism: Caenorhabditis briggsae

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q2KJD2 138
organism: Bos taurus

uniprot P63026 124
type: UnificationXref
id: P63026
db: uniprot

Protein kinase C-like 1B
type: ProteinReference
xref: PTHR24356:SF240
xref: uniprot P34885 512
organism: Caenorhabditis elegans

uniprot F7A632 478
type: UnificationXref
id: F7A632
db: uniprot

uniprot P61266 120
type: UnificationXref
id: P61266
db: uniprot

uniprot Q7UFM6 274
type: UnificationXref
id: Q7UFM6
db: uniprot

uniprot O08874 493
type: UnificationXref
id: O08874
db: uniprot

uniprot G5EDV9 173
type: UnificationXref
id: G5EDV9
db: uniprot

uniprot P62881 398
type: UnificationXref
id: P62881
db: uniprot

Glutamate receptor ionotropic, NMDA 3B
type: ProteinReference
evidence: Evidence 263
evidence: Evidence 234
xref: PTHR18966:SF364
xref: uniprot Q8VHN2 264
organism: Rattus norvegicus

uniprot A0A2I3REJ5 449
type: UnificationXref
id: A0A2I3REJ5
db: uniprot

uniprot F7G1K7 337
type: UnificationXref
id: F7G1K7
db: uniprot

Protein CBR-ITR-1, isoform a
type: ProteinReference
xref: PTHR13715:SF87
xref: uniprot H8WGV2 50
organism: Caenorhabditis briggsae

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63044 126
xref: PTHR45701:SF5
organism: Mus musculus

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63045 127
organism: Rattus norvegicus

uniprot P50153 383
type: UnificationXref
id: P50153
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r22
control type: ACTIVATION
controller: IP3R

uniprot H2PZC4 486
type: UnificationXref
id: H2PZC4
db: uniprot

Synaptobrevin-1
type: ProteinReference
xref: PTHR45701:SF3
xref: uniprot O02495 100
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot Q5E9F0 416
organism: Bos taurus

uniprot Q63433 537
type: UnificationXref
id: Q63433
db: uniprot

Acetyl CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Syntaxin 1A
type: ProteinReference
xref: uniprot Q0VFR6 130
xref: PTHR19957:SF84
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZSF0 292
organism: Branchiostoma floridae

uniprot Q8TCU5 262
type: UnificationXref
id: Q8TCU5
db: uniprot

axon terminus
type: CellularLocationVocabulary
xref: GO GO:0043679 3

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot Q7ZUC5 544
organism: Danio rerio

G protein subunit alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot A0A2I3TRC4 281
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r76 586
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

Vesicle-associated membrane protein 8 (Endobrevin)
type: ProteinReference
xref: uniprot Q7ZUC1 149
xref: PTHR45701:SF7
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r76 585
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot A0A3Q2UC01 165
organism: Gallus gallus

uniprot P38409 377
type: UnificationXref
id: P38409
db: uniprot

uniprot Q05586 251
type: UnificationXref
id: Q05586
db: uniprot

CHT1
type: ProteinReference
xref: P01072
standard name: high affinity choline transporter
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 1 and 3 signaling pathway.PROTEIN.GENERIC.CHT1
comment: ENTITY_REFERENCE_NOTES= Long Name: high affinity choline transporter Synonym: Synonym not specified Accession: P01072
member entity reference: SLC5A7 isoform 1
member entity reference: High affinity choline transporter 1
member entity reference: Protein CBR-CHO-1
member entity reference: Solute carrier family 5 member 7
member entity reference: Solute carrier family 5 (Choline transporter), member 7
member entity reference: High-affinity choline transporter 1
member entity reference: High affinity choline transporter
member entity reference: AGAP002366-PA
member entity reference: Uncharacterized protein

uniprot Q02956 525
type: UnificationXref
id: Q02956
db: uniprot

uniprot A8X8S6 75
type: UnificationXref
id: A8X8S6
db: uniprot

PTHR24356:SF159
type: RelationshipXref
id: PTHR24356:SF159
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q9QW07 197
organism: Rattus norvegicus

PTHR24356:SF158
type: RelationshipXref
id: PTHR24356:SF158
db: PANTHER Family
relationship type: By Homology

uniprot F7E427 330
type: UnificationXref
id: F7E427
db: uniprot

uniprot Q6DGZ5 426
type: UnificationXref
id: Q6DGZ5
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63027 125
xref: PTHR45701:SF5
organism: Homo sapiens

uniprot Q19266 532
type: UnificationXref
id: Q19266
db: uniprot

uniprot P38408 376
type: UnificationXref
id: P38408
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63026 124
xref: PTHR45701:SF5
organism: Bos taurus

PTHR24356:SF365
type: RelationshipXref
id: PTHR24356:SF365
db: PANTHER Family
relationship type: By Homology

uniprot P36975 113
type: UnificationXref
id: P36975
db: uniprot

uniprot P32738 25
type: UnificationXref
id: P32738
db: uniprot

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot G5EDV9 173
organism: Caenorhabditis elegans

Putative protein kinase C delta type homolog
type: ProteinReference
xref: PTHR24356:SF347
xref: uniprot P83099 520
organism: Drosophila melanogaster

uniprot P61953 390
type: UnificationXref
id: P61953
db: uniprot

uniprot Q9JMD7 278
type: UnificationXref
id: Q9JMD7
db: uniprot

uniprot Q6P025 428
type: UnificationXref
id: Q6P025
db: uniprot

uniprot Q9CXP8 442
type: UnificationXref
id: Q9CXP8
db: uniprot

uniprot D3ZLD6 293
type: UnificationXref
id: D3ZLD6
db: uniprot

PARTICIPANT STOICHIOMETRY r79 577
type: Stoichiometry
physical entity: NMDA
stoichiometric coefficient: 1.0

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63024 122
organism: Mus musculus

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63025 123
organism: Rattus norvegicus

Protein kinase C
type: ProteinReference
xref: uniprot F6RA79 474
xref: PTHR24356:SF193
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r79 578
type: Stoichiometry
physical entity: NMDA
stoichiometric coefficient: 1.0

Glutamate receptor ionotropic, NMDA3A
type: ProteinReference
evidence: Evidence 213
evidence: Evidence 218
xref: uniprot A2AIR5 217
xref: PTHR18966:SF397
organism: Mus musculus

uniprot Q66JF0 425
type: UnificationXref
id: Q66JF0
db: uniprot

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 315
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r70 606
type: Stoichiometry
physical entity: VAChT
stoichiometric coefficient: 1.0

uniprot G5EEN8 93
type: UnificationXref
id: G5EEN8
db: uniprot

PARTICIPANT STOICHIOMETRY r70 605
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

uniprot Q5RKP9 419
type: UnificationXref
id: Q5RKP9
db: uniprot

uniprot F7EBE7 331
type: UnificationXref
id: F7EBE7
db: uniprot

Syntaxin-1A
type: ProteinReference
xref: PTHR19957:SF84
xref: uniprot Q16623 132
organism: Homo sapiens

Muscarinic acetylcholine receptor 1 and 3 signaling pathway
type: Pathway
pathway component: DISSOCIATION_LEFT__Complex__VAChT_ACh_-RIGHT__ACh-_VAChT-_r70
pathway component: DISSOCIATION_LEFT__Complex__CHT1_choline_-RIGHT__choline-_CHT1-_r72
pathway component: DISSOCIATION_LEFT__ACh-_Complex__GDP_G_Protein__mAChR1_3_-_GTP-RIGHT__Complex__GTP_G_Protein_-_GDP-_Complex__mAChR1_3__ACh_-_r53
pathway component: STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_r75
pathway component: TRANSPORT_LEFT__Acetyl_CoA-RIGHT__Acetyl_CoA-_r73
pathway component: TRANSPORT_LEFT__ACh-RIGHT__ACh-_r74
pathway component: HETERODIMER_ASSOCIATION_LEFT__choline-_CHT1-RIGHT__Complex__CHT1_choline_-_r71
pathway component: DISSOCIATION_LEFT__ACh-RIGHT__choline-_Acetyl_CoA-_r59
pathway component: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r76
pathway component: HETERODIMER_ASSOCIATION_LEFT__choline-_Acetyl_CoA-RIGHT__ACh-_r56
pathway component: STATE_TRANSITION_LEFT__NMDA-RIGHT__NMDA-_r79
pathway component: DISSOCIATION_LEFT__PIP2-RIGHT__DAG-_IP3-_r8
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r22
pathway component: STATE_TRANSITION_LEFT__K_PLUS__channel-RIGHT__K_PLUS__channel-_r77
pathway component: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r46
pathway component: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_r78
pathway component: HETERODIMER_ASSOCIATION_LEFT__ACh-_VAChT-RIGHT__Complex__VAChT_ACh_-_r69
xref: PANTHER Pathway P00042 1
comment: MODEL_NOTES=Panther Pathway: P00042 Muscarinic Acetylcholine Receptor 1, 3 Pathway: Muscarinic ACh receptors are coupled to PLC and intracellular calcium signaling. These receptors are found in the brain controlling attention (eg. reduction of cholinergic fibers in elderly and trisomy 21 patients leads to Alzheimer's disease) and peripheral nervous system controlling parasympathetic responses (eg. release of acetylcholine from the vagus nerve reduces heart rate and blood pressure). These receptors are important drug targets for heart disease, hypertension, anesthesia and Alzheimer's disease, as well as recent cognitive enhancement drugs. Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11060805 Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7786837 Website=http://www.unifr.ch/biochem/DREYER/Neurotransmitters/acetylcholine.htm PMID: 11060805 PMID: 7786837

uniprot P07668 21
type: UnificationXref
id: P07668
db: uniprot

PARTICIPANT STOICHIOMETRY r70 604
type: Stoichiometry
physical entity: Complex (VAChT/ACh)
stoichiometric coefficient: 1.0

PTHR24356:SF162
type: RelationshipXref
id: PTHR24356:SF162
db: PANTHER Family
relationship type: By Homology

uniprot H2QJY5 192
type: UnificationXref
id: H2QJY5
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R9G5 299
organism: Canis lupus familiaris

Glutamate [NMDA] receptor subunit 1
type: ProteinReference
evidence: Evidence 234
xref: uniprot Q24418 255
xref: PTHR18966:SF377
organism: Drosophila melanogaster

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot O70404 105
organism: Mus musculus

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot O14775 357
organism: Homo sapiens

VAMP2 isoform 3
type: ProteinReference
xref: uniprot H2RCB8 97
xref: PTHR45701:SF5
organism: Pan troglodytes

uniprot Q9U295 186
type: UnificationXref
id: Q9U295
db: uniprot

Vesicle associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot F6Z5I2 88
organism: Monodelphis domestica

IP3
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9VH76 159
type: UnificationXref
id: Q9VH76
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot A0A2I3SSC7 34
xref: PTHR13715:SF52
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r59 607
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

uniprot F6VTB5 228
type: UnificationXref
id: F6VTB5
db: uniprot

PARTICIPANT STOICHIOMETRY r59 608
type: Stoichiometry
physical entity: choline
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 609
type: Stoichiometry
physical entity: Acetyl CoA
stoichiometric coefficient: 1.0

uniprot Q7T2C5 543
type: UnificationXref
id: Q7T2C5
db: uniprot

uniprot P60877 114
type: UnificationXref
id: P60877
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 298
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R2S3 297
organism: Canis lupus familiaris

PTHR18966:SF397
type: RelationshipXref
id: PTHR18966:SF397
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3TRC4 281
type: UnificationXref
id: A0A2I3TRC4
db: uniprot

PTHR18966:SF391
type: RelationshipXref
id: PTHR18966:SF391
db: PANTHER Family
relationship type: By Homology

uniprot H2Q5I0 235
type: UnificationXref
id: H2Q5I0
db: uniprot

uniprot Q24547 136
type: UnificationXref
id: Q24547
db: uniprot

MODULATION
type: RelationshipTypeVocabulary

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot Q62074 536
organism: Mus musculus

uniprot P32756 27
type: UnificationXref
id: P32756
db: uniprot

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot Q9JID2 444
organism: Rattus norvegicus

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 18

00696
type: UnificationXref
id: MOD:00696
db: mod

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F8W3G9 343
organism: Danio rerio

G protein subunit alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot F7G1U7 338
organism: Monodelphis domestica

PTHR13715:SF87
type: RelationshipXref
id: PTHR13715:SF87
db: PANTHER Family
relationship type: By Homology

PTHR10336:SF106
type: RelationshipXref
id: PTHR10336:SF106
db: PANTHER Family
relationship type: By Homology

choline s12 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: choline
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_r75
controller: Complex (GTP/G-Protein)

PTHR18966:SF385
type: RelationshipXref
id: PTHR18966:SF385
db: PANTHER Family
relationship type: By Homology

PTHR18966:SF382
type: RelationshipXref
id: PTHR18966:SF382
db: PANTHER Family
relationship type: By Homology

AGAP002366-PA
type: ProteinReference
xref: PTHR45897:SF4
xref: uniprot Q7QBY8 273
organism: Anopheles gambiae

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r22
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 582
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 581
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

Glutamate ionotropic receptor NMDA type subunit 3A
type: ProteinReference
evidence: Evidence 213
evidence: Evidence 218
xref: PTHR18966:SF397
xref: uniprot E1BK87 220
organism: Bos taurus

PTHR18966:SF377
type: RelationshipXref
id: PTHR18966:SF377
db: PANTHER Family
relationship type: By Homology

GO GO:0005783 4
type: UnificationXref
id: GO:0005783
db: GO

PTHR24248:SF155
type: RelationshipXref
id: PTHR24248:SF155
db: PANTHER Family
relationship type: By Homology

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot O95721 106
organism: Homo sapiens

AGAP002370-PA (Fragment)
type: ProteinReference
xref: uniprot Q7QBZ0 32
xref: PTHR22589:SF14
organism: Anopheles gambiae

uniprot Q08BT6 529
type: UnificationXref
id: Q08BT6
db: uniprot

uniprot P21279 365
type: UnificationXref
id: P21279
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: uniprot P41743 515
xref: PTHR24356:SF214
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot W4Y9B6 163
organism: Strongylocentrotus purpuratus

uniprot Q91UZ1 196
type: UnificationXref
id: Q91UZ1
db: uniprot

DISSOCIATION
type: RelationshipTypeVocabulary

PTHR24248:SF153
type: RelationshipXref
id: PTHR24248:SF153
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__K_PLUS__channel-RIGHT__K_PLUS__channel-_r77
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 584
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 583
left: K+ channel
interaction type: STATE_TRANSITION
right: K+ channel

uniprot A0A3Q1MSP9 455
type: UnificationXref
id: A0A3Q1MSP9
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot K7CBH8 492
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r78 579
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

uniprot F1MY82 469
type: UnificationXref
id: F1MY82
db: uniprot

uniprot P05771 498
type: UnificationXref
id: P05771
db: uniprot

PTHR24356:SF390
type: RelationshipXref
id: PTHR24356:SF390
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50150 381
organism: Homo sapiens

GO GO:0005829 5
type: UnificationXref
id: GO:0005829
db: GO

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot P50151 382
organism: Homo sapiens

uniprot A0A2J8M701 199
type: UnificationXref
id: A0A2J8M701
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot P50154 384
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50153 383
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r78 580
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: uniprot P50148 380
xref: PTHR10218:SF316
organism: Homo sapiens

PTHR18966:SF361
type: RelationshipXref
id: PTHR18966:SF361
db: PANTHER Family
relationship type: By Homology

PTHR18966:SF364
type: RelationshipXref
id: PTHR18966:SF364
db: PANTHER Family
relationship type: By Homology

uniprot F1PVP1 79
type: UnificationXref
id: F1PVP1
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot F7HC75 485
organism: Macaca mulatta

uniprot Q64617 538
type: UnificationXref
id: Q64617
db: uniprot

uniprot P36583 514
type: UnificationXref
id: P36583
db: uniprot

AGAP002369-PA
type: ProteinReference
xref: uniprot Q7PR83 69
xref: PTHR23506:SF13
organism: Anopheles gambiae

Muscarinic acetylcholine receptor M3
type: ProteinReference
xref: PTHR24247:SF183
xref: uniprot Q9ERZ3 211
organism: Mus musculus

uniprot P70227 56
type: UnificationXref
id: P70227
db: uniprot

uniprot P38433 181
type: UnificationXref
id: P38433
db: uniprot

ncbitaxon 665079 288
type: UnificationXref
id: 665079
db: ncbitaxon

ncbitaxon 44689 374
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot P31109 109
type: UnificationXref
id: P31109
db: uniprot

STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r46
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 589
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 590
left: PKC
interaction type: STATE_TRANSITION
right: PKC

IP3R
type: Protein
entity reference: IP3R
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot F7HC75 485
type: UnificationXref
id: F7HC75
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot A0A3Q2U0G2 187
xref: PTHR10336:SF106
organism: Gallus gallus

uniprot Q9SD96 158
type: UnificationXref
id: Q9SD96
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot F6YMH2 87
organism: Macaca mulatta

uniprot F6TFY2 317
type: UnificationXref
id: F6TFY2
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot F6VHF7 43
type: UnificationXref
id: F6VHF7
db: uniprot

PARTICIPANT STOICHIOMETRY r71 598
type: Stoichiometry
physical entity: choline
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DNS6 90
xref: PTHR19957:SF334
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r71 599
type: Stoichiometry
physical entity: CHT1
stoichiometric coefficient: 1.0

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q9BV40 152
xref: PTHR45701:SF7
organism: Homo sapiens

uniprot R4GKD1 447
type: UnificationXref
id: R4GKD1
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__K_PLUS__channel-RIGHT__K_PLUS__channel-_r77
controller: PKC

Vesicular acetylcholine transporter
type: ProteinReference
xref: uniprot O17444 66
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A943 89
xref: PTHR45701:SF5
organism: Monodelphis domestica

uniprot P29829 369
type: UnificationXref
id: P29829
db: uniprot

Soluble NSF attachment protein 29
type: ProteinReference
xref: uniprot P83351 128
xref: PTHR19305:SF9
organism: Caenorhabditis elegans

uniprot A0A3Q2U0G2 187
type: UnificationXref
id: A0A3Q2U0G2
db: uniprot

High affinity choline transporter 1
type: ProteinReference
xref: uniprot Q9GZV3 277
organism: Homo sapiens

Protein kinase C eta type
type: ProteinReference
xref: uniprot F1MY82 469
xref: PTHR24356:SF192
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR45897:SF2
xref: uniprot F6QHN1 270
organism: Macaca mulatta

G protein subunit beta 5
type: ProteinReference
xref: uniprot H2Q9G5 349
organism: Pan troglodytes

Muscarinic acetylcholine receptor M1
type: ProteinReference
xref: uniprot P12657 209
xref: PTHR24247:SF182
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: uniprot H2QDQ1 489
xref: PTHR24356:SF193
organism: Pan troglodytes

uniprot Q7Q6D2 435
type: UnificationXref
id: Q7Q6D2
db: uniprot

VAChT s9 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: VAChT
stoichiometric coefficient: 1.0

IP3R
type: Protein
entity reference: IP3R
feature: ACTIVE 64
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F1P1X4 40
xref: PTHR13715:SF53
organism: Gallus gallus

uniprot Q9LMG8 154
type: UnificationXref
id: Q9LMG8
db: uniprot

uniprot Q5R1P0 256
type: UnificationXref
id: Q5R1P0
db: uniprot

uniprot P60879 116
type: UnificationXref
id: P60879
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63219 406
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 405
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63217 404
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63216 403
organism: Mus musculus

uniprot F6RLG5 17
type: UnificationXref
id: F6RLG5
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 402
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63214 401
organism: Bos taurus

PTHR43918:SF4
type: RelationshipXref
id: PTHR43918:SF4
db: PANTHER Family
relationship type: By Homology

uniprot Q28FH0 411
type: UnificationXref
id: Q28FH0
db: uniprot

PTHR43918:SF5
type: RelationshipXref
id: PTHR43918:SF5
db: PANTHER Family
relationship type: By Homology

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 7

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q15KE4 409
organism: Danio rerio

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 28

uniprot Q9JKC1 185
type: UnificationXref
id: Q9JKC1
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot P13217 194
organism: Drosophila melanogaster

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot P29829 369
organism: Drosophila melanogaster

uniprot Q17499 31
type: UnificationXref
id: Q17499
db: uniprot

uniprot P83099 520
type: UnificationXref
id: P83099
db: uniprot

Syntaxin 1B
type: ProteinReference
xref: uniprot F7EP58 91
xref: PTHR19957:SF334
organism: Xenopus tropicalis

High-affinity choline transporter 1
type: ProteinReference
xref: uniprot Q9VE46 279
organism: Drosophila melanogaster

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7F580 335
organism: Macaca mulatta

PTHR19957:SF334
type: RelationshipXref
id: PTHR19957:SF334
db: PANTHER Family
relationship type: By Homology

PTHR45897:SF2
type: RelationshipXref
id: PTHR45897:SF2
db: PANTHER Family
relationship type: By Homology

uniprot Q15KE4 409
type: UnificationXref
id: Q15KE4
db: uniprot

PTHR45897:SF4
type: RelationshipXref
id: PTHR45897:SF4
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot Q9CXP8 442
organism: Mus musculus

Muscarinic acetylcholine receptor
type: ProteinReference
xref: PTHR24248:SF155
xref: uniprot F7HUF6 204
organism: Macaca mulatta

PTHR43918:SF3
type: RelationshipXref
id: PTHR43918:SF3
db: PANTHER Family
relationship type: By Homology

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__ACh-RIGHT__ACh-_r74
control type: ACTIVATION
controller: SNARE COMPLEX

uniprot A0A3Q1LM61 453
type: UnificationXref
id: A0A3Q1LM61
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 214
evidence: Evidence 213
evidence: Evidence 215
evidence: Evidence 216
xref: PTHR18966:SF407
xref: uniprot A0A1D5QE40 212
organism: Macaca mulatta

G protein subunit alpha q
type: ProteinReference
xref: uniprot E1BA29 294
xref: PTHR10218:SF316
organism: Bos taurus

uniprot Q1MTI1 134
type: UnificationXref
id: Q1MTI1
db: uniprot

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot A0A1D5QG31 280
organism: Macaca mulatta

ACh s10 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RGI5 301
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RLG5 17
xref: PTHR22589:SF14
organism: Macaca mulatta

Protein kinase C delta type
type: ProteinReference
xref: uniprot A0A3Q1MRR6 454
xref: PTHR24356:SF365
organism: Bos taurus

uniprot P17252 505
type: UnificationXref
id: P17252
db: uniprot

uniprot O60262 358
type: UnificationXref
id: O60262
db: uniprot

uniprot G3V8K2 344
type: UnificationXref
id: G3V8K2
db: uniprot

uniprot Q15836 131
type: UnificationXref
id: Q15836
db: uniprot

Synaptobrevin
type: ProteinReference
xref: PTHR45701:SF10
xref: uniprot P18489 107
organism: Drosophila melanogaster

Acetylcholinesterase
type: ProteinReference
xref: PTHR43918:SF3
xref: uniprot Q9DDE3 184
organism: Danio rerio

TRANSPORT
type: RelationshipTypeVocabulary

SNAP25 homologous protein SNAP29
type: ProteinReference
xref: uniprot Q9SD96 158
organism: Arabidopsis thaliana

AGAP006475-PA
type: ProteinReference
xref: PTHR13715:SF87
xref: uniprot Q5TQX0 60
organism: Anopheles gambiae

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 288

uniprot Q7QBZ0 32
type: UnificationXref
id: Q7QBZ0
db: uniprot

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P17343 362
organism: Caenorhabditis elegans

uniprot P43425 378
type: UnificationXref
id: P43425
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot Q90XF2 547
organism: Danio rerio

STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r76
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 585
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 586
left: IP3R
interaction type: STATE_TRANSITION
right: IP3R

uniprot Q7ZUC5 544
type: UnificationXref
id: Q7ZUC5
db: uniprot

uniprot O02495 100
type: UnificationXref
id: O02495
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F6VT32 476
xref: PTHR24356:SF192
organism: Xenopus tropicalis

PTHR24247:SF182
type: RelationshipXref
id: PTHR24247:SF182
db: PANTHER Family
relationship type: By Homology

uniprot H9FVW1 193
type: UnificationXref
id: H9FVW1
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3SZ98 414
organism: Bos taurus

ncbitaxon 9598 20
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot P13677 502
type: UnificationXref
id: P13677
db: uniprot

Synaptosomal-associated protein 25-A
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q5TZ66 144
organism: Danio rerio

uniprot P63025 123
type: UnificationXref
id: P63025
db: uniprot

PTHR24247:SF183
type: RelationshipXref
id: PTHR24247:SF183
db: PANTHER Family
relationship type: By Homology

uniprot Q04759 526
type: UnificationXref
id: Q04759
db: uniprot

Choline O-acetyltransferase
type: ProteinReference
xref: uniprot F1MLQ5 10
xref: PTHR22589:SF14
organism: Bos taurus

uniprot Q6PBY0 431
type: UnificationXref
id: Q6PBY0
db: uniprot

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa2 556
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A5PEW5 74
xref: PTHR19305:SF14
organism: Caenorhabditis elegans

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot P11881 52
xref: PTHR13715:SF52
organism: Mus musculus

uniprot H2Q1W2 65
type: UnificationXref
id: H2Q1W2
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)
type: ProteinReference
xref: uniprot F6THW2 318
xref: PTHR10218:SF328
organism: Xenopus tropicalis

Ca2+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

HETERODIMER_ASSOCIATION_LEFT__ACh-_VAChT-RIGHT__Complex__VAChT_ACh_-_r69
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 603
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 602
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 601
left: ACh
left: VAChT
interaction type: HETERODIMER_ASSOCIATION
right: Complex (VAChT/ACh)

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 168

uniprot Q8BWW9 545
type: UnificationXref
id: Q8BWW9
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q1D9 347
organism: Pan troglodytes

uniprot O17444 66
type: UnificationXref
id: O17444
db: uniprot

uniprot E2RGU7 464
type: UnificationXref
id: E2RGU7
db: uniprot

Carboxylic ester hydrolase
type: ProteinReference
xref: PTHR43918:SF3
xref: uniprot F7HPD8 171
organism: Macaca mulatta

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 8

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P52287 385
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot Q91UZ1 196
xref: PTHR10336:SF106
organism: Mus musculus

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F6UBJ8 80
xref: PTHR19305:SF4
organism: Xenopus tropicalis

Synaptobrevin homolog 2
type: ProteinReference
xref: uniprot P33328 112
organism: Saccharomyces cerevisiae

uniprot P16520 361
type: UnificationXref
id: P16520
db: uniprot

Ca2+
type: SmallMolecule
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=ION

uniprot F7C0E0 481
type: UnificationXref
id: F7C0E0
db: uniprot

Syntaxin-1A
type: ProteinReference
xref: uniprot P32851 111
xref: PTHR19957:SF84
organism: Rattus norvegicus

ncbitaxon 6239 28
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot Q6R6I2 259
type: UnificationXref
id: Q6R6I2
db: uniprot

uniprot Q6PBR4 430
type: UnificationXref
id: Q6PBR4
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot F1M7Y5 466
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot F7G1K7 337
organism: Monodelphis domestica

uniprot O14610 356
type: UnificationXref
id: O14610
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 42

PLC
type: Protein
entity reference: PLC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q80SZ7 440
type: UnificationXref
id: Q80SZ7
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7AE17 354
organism: Pan troglodytes

mAChR1 3 s7 sa6 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.4633432079864352
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Glutamate receptor ionotropic, NMDA 2A
type: ProteinReference
evidence: Evidence 234
evidence: Evidence 242
evidence: Evidence 238
evidence: Evidence 241
xref: PTHR18966:SF407
xref: uniprot P35436 240
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot F1NG47 470
organism: Gallus gallus

uniprot A2AIR5 217
type: UnificationXref
id: A2AIR5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 295
organism: Gallus gallus

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot F7BIC2 479
organism: Macaca mulatta

uniprot P29995 55
type: UnificationXref
id: P29995
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot F6VUT7 83
organism: Ornithorhynchus anatinus

Synaptosomal-associated protein 23
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot O00161 99
organism: Homo sapiens

Protein kinase C eta type
type: ProteinReference
xref: uniprot E2RGU7 464
xref: PTHR24356:SF192
organism: Canis lupus familiaris

uniprot E1C795 296
type: UnificationXref
id: E1C795
db: uniprot

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot C3ZRW7 169
xref: PTHR11559:SF397
organism: Branchiostoma floridae

uniprot P05130 497
type: UnificationXref
id: P05130
db: uniprot

uniprot H2PZA6 346
type: UnificationXref
id: H2PZA6
db: uniprot

Protein kinase C gamma type
type: ProteinReference
xref: uniprot P05129 496
xref: PTHR24356:SF162
organism: Homo sapiens

uniprot H2Q3X5 205
type: UnificationXref
id: H2Q3X5
db: uniprot

uniprot Q7SZZ5 148
type: UnificationXref
id: Q7SZZ5
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05126 494
xref: PTHR24356:SF158
organism: Bos taurus

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 234
evidence: Evidence 242
xref: PTHR18966:SF382
xref: uniprot Q13224 253
organism: Homo sapiens

Protein kinase C gamma type (Fragment)
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P05128 495
organism: Bos taurus

uniprot F1PRG8 78
type: UnificationXref
id: F1PRG8
db: uniprot

uniprot A0A1D5QE40 212
type: UnificationXref
id: A0A1D5QE40
db: uniprot

Serine/threonine-protein kinase N3
type: ProteinReference
xref: uniprot Q8K045 546
xref: PTHR24356:SF318
organism: Mus musculus

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot F6R543 41
xref: PTHR13715:SF51
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 339
organism: Monodelphis domestica

uniprot P35438 243
type: UnificationXref
id: P35438
db: uniprot

uniprot Q5E9F0 416
type: UnificationXref
id: Q5E9F0
db: uniprot

uniprot F7HPD8 171
type: UnificationXref
id: F7HPD8
db: uniprot

ncbitaxon 3702 155
type: UnificationXref
id: 3702
db: ncbitaxon

Choline O-acetyltransferase
type: ProteinReference
xref: uniprot P28329 23
xref: PTHR22589:SF14
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot G5EBH0 191
organism: Caenorhabditis elegans

PTHR23506:SF13
type: RelationshipXref
id: PTHR23506:SF13
db: PANTHER Family
relationship type: By Homology

Vesicle associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot F1PRG8 78
organism: Canis lupus familiaris

uniprot P62872 393
type: UnificationXref
id: P62872
db: uniprot

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P20444 506
organism: Mus musculus

uniprot A0A3Q1MRR6 454
type: UnificationXref
id: A0A3Q1MRR6
db: uniprot

uniprot P63318 516
type: UnificationXref
id: P63318
db: uniprot

DAG
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot Q9ERB0 153
xref: PTHR19305:SF9
organism: Mus musculus

Inositol 1,4,5-trisphosphate receptor itr-1
type: ProteinReference
xref: PTHR13715:SF87
xref: uniprot Q9Y0A1 62
organism: Caenorhabditis elegans

Protein kinase C, brain isozyme
type: ProteinReference
xref: uniprot P05130 497
xref: PTHR24356:SF390
organism: Drosophila melanogaster

Acetylcholinesterase
type: ProteinReference
xref: uniprot P22303 178
organism: Homo sapiens

uniprot E2R2S8 298
type: UnificationXref
id: E2R2S8
db: uniprot

PTHR13715:SF52
type: RelationshipXref
id: PTHR13715:SF52
db: PANTHER Family
relationship type: By Homology

PTHR13715:SF51
type: RelationshipXref
id: PTHR13715:SF51
db: PANTHER Family
relationship type: By Homology

PTHR13715:SF53
type: RelationshipXref
id: PTHR13715:SF53
db: PANTHER Family
relationship type: By Homology

Protein kinase C-like 2
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P36583 514
organism: Schizosaccharomyces pombe

ncbitaxon 559292 110
type: UnificationXref
id: 559292
db: ncbitaxon

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 443
organism: Homo sapiens

Syntaxin-1A
type: ProteinReference
xref: uniprot O35526 102
xref: PTHR19957:SF84
organism: Mus musculus

Protein kinase C-like 1
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P36582 513
organism: Schizosaccharomyces pombe

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot P38408 376
organism: Bos taurus

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot P38409 377
organism: Bos taurus

uniprot P30671 371
type: UnificationXref
id: P30671
db: uniprot

uniprot E2RMC0 38
type: UnificationXref
id: E2RMC0
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot Q10282 408
organism: Schizosaccharomyces pombe

PARTICIPANT STOICHIOMETRY r56 613
type: Stoichiometry
physical entity: choline
stoichiometric coefficient: 1.0

uniprot P63078 400
type: UnificationXref
id: P63078
db: uniprot

uniprot F5HH30 313
type: UnificationXref
id: F5HH30
db: uniprot

PARTICIPANT STOICHIOMETRY r56 615
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r56 614
type: Stoichiometry
physical entity: Acetyl CoA
stoichiometric coefficient: 1.0

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 234
evidence: Evidence 242
xref: PTHR18966:SF382
xref: uniprot Q00960 246
organism: Rattus norvegicus

Glutamate receptor ionotropic, NMDA 2C
type: ProteinReference
evidence: Evidence 234
evidence: Evidence 238
xref: PTHR18966:SF361
xref: uniprot Q00961 247
organism: Rattus norvegicus

uniprot H2QLA1 95
type: UnificationXref
id: H2QLA1
db: uniprot

uniprot Q16572 67
type: UnificationXref
id: Q16572
db: uniprot

uniprot P11229 208
type: UnificationXref
id: P11229
db: uniprot

CAT
type: Protein
entity reference: CAT
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RJB3 303
organism: Canis lupus familiaris

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 155

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot F5HMB9 189
organism: Anopheles gambiae

Glutamate ionotropic receptor NMDA type subunit 3A
type: ProteinReference
evidence: Evidence 213
evidence: Evidence 218
xref: uniprot H2QZZ2 236
xref: PTHR18966:SF397
organism: Pan troglodytes

uniprot H9EU39 491
type: UnificationXref
id: H9EU39
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P18851 363
organism: Saccharomyces cerevisiae

Uncharacterized protein
type: ProteinReference
xref: PTHR24356:SF322
xref: uniprot F1MFK1 468
organism: Bos taurus

Guanine nucleotide-binding protein subunit beta-5b
type: ProteinReference
xref: uniprot Q6PBY0 431
organism: Danio rerio

uniprot Q63269 61
type: UnificationXref
id: Q63269
db: uniprot

Serine/threonine-protein kinase N2
type: ProteinReference
xref: PTHR24356:SF322
xref: uniprot O08874 493
organism: Rattus norvegicus

Gbeta5
type: ProteinReference
xref: uniprot Q9W3J1 446
organism: Drosophila melanogaster

PTHR45701:SF6
type: RelationshipXref
id: PTHR45701:SF6
db: PANTHER Family
relationship type: By Homology

PKN3 isoform 1
type: ProteinReference
xref: uniprot H2QXZ6 490
xref: PTHR24356:SF318
organism: Pan troglodytes

PTHR45701:SF7
type: RelationshipXref
id: PTHR45701:SF7
db: PANTHER Family
relationship type: By Homology

G protein subunit gamma 5
type: ProteinReference
xref: uniprot H2PZA6 346
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1PJE5 311
organism: Canis lupus familiaris

PTHR45701:SF5
type: RelationshipXref
id: PTHR45701:SF5
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF3
type: RelationshipXref
id: PTHR45701:SF3
db: PANTHER Family
relationship type: By Homology

uniprot Q03059 29
type: UnificationXref
id: Q03059
db: uniprot

Glutamate receptor ionotropic, NMDA 2A
type: ProteinReference
evidence: Evidence 234
evidence: Evidence 242
evidence: Evidence 238
evidence: Evidence 241
xref: PTHR18966:SF407
xref: uniprot Q00959 245
organism: Rattus norvegicus

PTHR45701:SF1
type: RelationshipXref
id: PTHR45701:SF1
db: PANTHER Family
relationship type: By Homology

uniprot P24723 509
type: UnificationXref
id: P24723
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot Q9UK08 445
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor
type: ProteinReference
xref: PTHR13715:SF87
xref: uniprot P29993 53
organism: Drosophila melanogaster

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot P29992 370
xref: PTHR10218:SF328
organism: Homo sapiens

Serine/threonine-protein kinase N1
type: ProteinReference
xref: uniprot P70268 519
xref: PTHR24356:SF246
organism: Mus musculus

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot P29995 55
organism: Rattus norvegicus

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot P29994 54
xref: PTHR13715:SF52
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r74 592
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r74 591
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

uniprot O14775 357
type: UnificationXref
id: O14775
db: uniprot

uniprot Q7PR83 69
type: UnificationXref
id: Q7PR83
db: uniprot

uniprot F1N5C5 201
type: UnificationXref
id: F1N5C5
db: uniprot

uniprot O00161 99
type: UnificationXref
id: O00161
db: uniprot

G protein subunit alpha q
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot K6ZCJ5 353
organism: Pan troglodytes

Danio rerio
type: BioSource
xref: ncbitaxon 7955 135

uniprot E1BK87 220
type: UnificationXref
id: E1BK87
db: uniprot

uniprot C3ZSF0 292
type: UnificationXref
id: C3ZSF0
db: uniprot

PTHR23506:SF23
type: RelationshipXref
id: PTHR23506:SF23
db: PANTHER Family
relationship type: By Homology

uniprot E1BMG4 461
type: UnificationXref
id: E1BMG4
db: uniprot

AGAP007698-PB
type: ProteinReference
xref: uniprot Q5TX47 143
organism: Anopheles gambiae

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot A0A2J8Q8V8 164
xref: PTHR11559:SF397
organism: Pan troglodytes

Protein kinase C, eye isozyme
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P13677 502
organism: Drosophila melanogaster

uniprot H2RCB8 97
type: UnificationXref
id: H2RCB8
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot Q7SY24 542
organism: Danio rerio

Cholinesterase
type: ProteinReference
xref: uniprot Q03311 182
organism: Mus musculus

uniprot A0A1D5QG31 280
type: UnificationXref
id: A0A1D5QG31
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF240
xref: uniprot P13678 503
organism: Drosophila melanogaster

uniprot P36408 373
type: UnificationXref
id: P36408
db: uniprot

uniprot P13678 503
type: UnificationXref
id: P13678
db: uniprot

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 282
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__ACh-RIGHT__choline-_Acetyl_CoA-_r59
controller: AChE

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q17QQ3 133
organism: Bos taurus

uniprot P23625 366
type: UnificationXref
id: P23625
db: uniprot

PARTICIPANT STOICHIOMETRY r53 571
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

Syntaxin 1B
type: ProteinReference
xref: PTHR19957:SF334
xref: uniprot F6WJB1 85
organism: Monodelphis domestica

uniprot B8JLJ7 291
type: UnificationXref
id: B8JLJ7
db: uniprot

Guanine nucleotide binding protein, q polypeptide
type: ProteinReference
xref: PTHR10218:SF329
xref: uniprot E9GJ31 306
organism: Daphnia pulex

PARTICIPANT STOICHIOMETRY r53 573
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 572
type: Stoichiometry
physical entity: Complex (GDP/G-Protein/ mAChR1/3)
stoichiometric coefficient: 1.0

uniprot F6VM87 82
type: UnificationXref
id: F6VM87
db: uniprot

uniprot P28329 23
type: UnificationXref
id: P28329
db: uniprot

uniprot P05126 494
type: UnificationXref
id: P05126
db: uniprot

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa5 552
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot E1BKE7 37
xref: PTHR13715:SF51
organism: Bos taurus

Solute carrier family 5 (Choline transporter), member 7
type: ProteinReference
xref: PTHR45897:SF2
xref: uniprot Q2KI26 272
organism: Bos taurus

uniprot P07140 176
type: UnificationXref
id: P07140
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot Q9N0Y0 156
xref: PTHR45701:SF5
organism: Macaca mulatta

Protein kinase C
type: ProteinReference
xref: PTHR24351:SF182
xref: uniprot F1MDC9 467
organism: Bos taurus

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q3T0Y8 139
organism: Bos taurus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P36975 113
xref: PTHR19305:SF14
organism: Drosophila melanogaster

DISSOCIATION_LEFT__ACh-RIGHT__choline-_Acetyl_CoA-_r59
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 609
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 608
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 607
left: ACh
interaction type: DISSOCIATION
right: Acetyl CoA
right: choline

uniprot P54311 386
type: UnificationXref
id: P54311
db: uniprot

PTHR22589:SF14
type: RelationshipXref
id: PTHR22589:SF14
db: PANTHER Family
relationship type: By Homology

uniprot A8X694 6
type: UnificationXref
id: A8X694
db: uniprot

uniprot A0A1D5R985 448
type: UnificationXref
id: A0A1D5R985
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 323
organism: Monodelphis domestica

uniprot P70268 519
type: UnificationXref
id: P70268
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q15836 131
organism: Homo sapiens

uniprot F1MX21 39
type: UnificationXref
id: F1MX21
db: uniprot

PKC
type: Protein
entity reference: PKC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q5ASG1 140
type: UnificationXref
id: Q5ASG1
db: uniprot

Serine/threonine-protein kinase N1
type: ProteinReference
xref: uniprot A1A4I4 456
xref: PTHR24356:SF246
organism: Bos taurus

PKN2 isoform 2
type: ProteinReference
xref: PTHR24356:SF322
xref: uniprot H2PZC4 486
organism: Pan troglodytes

Synaptosomal-associated protein 25-B
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q6PC54 147
organism: Danio rerio

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot O44419 103
organism: Strongylocentrotus purpuratus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q15147 195
organism: Homo sapiens

Protein kinase C
type: ProteinReference
xref: uniprot F6XMN6 477
xref: PTHR24356:SF170
organism: Canis lupus familiaris

uniprot P63044 126
type: UnificationXref
id: P63044
db: uniprot

uniprot H2QNS5 350
type: UnificationXref
id: H2QNS5
db: uniprot

uniprot K7E376 355
type: UnificationXref
id: K7E376
db: uniprot

Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
type: ProteinReference
xref: uniprot Q6DH55 427
organism: Danio rerio

NMDA s50 a55 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.27

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6TFY2 317
organism: Macaca mulatta

uniprot Q02156 524
type: UnificationXref
id: Q02156
db: uniprot

PKC
type: Protein
entity reference: PKC
feature: ACTIVE 64
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q5R1X1 142
type: UnificationXref
id: Q5R1X1
db: uniprot

PARTICIPANT STOICHIOMETRY r71 600
type: Stoichiometry
physical entity: Complex (CHT1/choline)
stoichiometric coefficient: 1.0

uniprot Q9Y0A1 62
type: UnificationXref
id: Q9Y0A1
db: uniprot

uniprot Q24418 255
type: UnificationXref
id: Q24418
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q62442 145
organism: Mus musculus

uniprot H2QXZ6 490
type: UnificationXref
id: H2QXZ6
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 26

uniprot P29992 370
type: UnificationXref
id: P29992
db: uniprot

uniprot P21278 364
type: UnificationXref
id: P21278
db: uniprot

DISSOCIATION_LEFT__ACh-_Complex__GDP_G_Protein__mAChR1_3_-_GTP-RIGHT__Complex__GTP_G_Protein_-_GDP-_Complex__mAChR1_3__ACh_-_r53
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 576
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 575
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 573
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 572
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 571
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 574
left: GTP
left: ACh
left: Complex (GDP/G-Protein/ mAChR1/3)
interaction type: DISSOCIATION
right: Complex (mAChR1/3/ ACh)
right: GDP
right: Complex (GTP/G-Protein)

uniprot P61265 119
type: UnificationXref
id: P61265
db: uniprot

Glutamate receptor ionotropic, NMDA 2C
type: ProteinReference
evidence: Evidence 234
evidence: Evidence 238
xref: PTHR18966:SF361
xref: uniprot Q14957 254
organism: Homo sapiens

uniprot Q6ZM67 260
type: UnificationXref
id: Q6ZM67
db: uniprot

uniprot A7EDU2 287
type: UnificationXref
id: A7EDU2
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot Q05655 528
organism: Homo sapiens

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 305

uniprot Q9JID2 444
type: UnificationXref
id: Q9JID2
db: uniprot

PARTICIPANT STOICHIOMETRY r53 576
type: Stoichiometry
physical entity: Complex (mAChR1/3/ ACh)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 574
type: Stoichiometry
physical entity: Complex (GTP/G-Protein)
stoichiometric coefficient: 1.0

uniprot F7GR67 231
type: UnificationXref
id: F7GR67
db: uniprot

PARTICIPANT STOICHIOMETRY r53 575
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Cholinergic receptor muscarinic 3
type: ProteinReference
xref: uniprot A0A452DI80 200
xref: PTHR24247:SF183
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot E1BWA3 463
organism: Gallus gallus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63078 400
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 399
organism: Rattus norvegicus

uniprot A0A3Q2UD13 36
type: UnificationXref
id: A0A3Q2UD13
db: uniprot

Evidence 263
type: Evidence
evidence code: IC
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html

uniprot P61267 121
type: UnificationXref
id: P61267
db: uniprot

ncbitaxon 237561 534
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot P50154 384
type: UnificationXref
id: P50154
db: uniprot

uniprot P05128 495
type: UnificationXref
id: P05128
db: uniprot

uniprot Q62666 68
type: UnificationXref
id: Q62666
db: uniprot

LD03592p
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9W1I8 160
organism: Drosophila melanogaster

ncbitaxon 9258 84
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot E2QUL1 221
type: UnificationXref
id: E2QUL1
db: uniprot

uniprot F1M7Y5 466
type: UnificationXref
id: F1M7Y5
db: uniprot

uniprot P63214 401
type: UnificationXref
id: P63214
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r46
controller: DAG

Syntaxin 1A
type: ProteinReference
xref: uniprot F1PVP1 79
xref: PTHR19957:SF84
organism: Canis lupus familiaris

uniprot F6XYX9 86
type: UnificationXref
id: F6XYX9
db: uniprot

uniprot Q3KRE3 413
type: UnificationXref
id: Q3KRE3
db: uniprot

ncbitaxon 8364 44
type: UnificationXref
id: 8364
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 387
organism: Rattus norvegicus

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 234
xref: uniprot P35438 243
xref: PTHR18966:SF377
organism: Mus musculus

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 234
xref: uniprot P35439 244
xref: PTHR18966:SF377
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 386
organism: Rattus norvegicus

Putative SNAP25 homologous protein SNAP30
type: ProteinReference
xref: uniprot Q9LMG8 154
organism: Arabidopsis thaliana

uniprot E2R907 77
type: UnificationXref
id: E2R907
db: uniprot

uniprot E7F101 222
type: UnificationXref
id: E7F101
db: uniprot

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot E2RP98 170
xref: PTHR11559:SF397
organism: Canis lupus familiaris

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa1 554
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot H9FVW1 193
organism: Macaca mulatta

ncbitaxon 6238 7
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot F7H6T7 342
type: UnificationXref
id: F7H6T7
db: uniprot

GRIN2B isoform 3
type: ProteinReference
evidence: Evidence 213
evidence: Evidence 216
xref: PTHR18966:SF382
xref: uniprot H2Q5I0 235
organism: Pan troglodytes

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 330
organism: Ornithorhynchus anatinus

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q0V7N0 129
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot A0A2I3RQJ8 450
organism: Pan troglodytes

uniprot A8WR64 460
type: UnificationXref
id: A8WR64
db: uniprot

G protein subunit alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot Q5EAP4 417
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 432
organism: Danio rerio

uniprot O02228 271
type: UnificationXref
id: O02228
db: uniprot

uniprot Q8BGY9 276
type: UnificationXref
id: Q8BGY9
db: uniprot

uniprot P50151 382
type: UnificationXref
id: P50151
db: uniprot

PARTICIPANT STOICHIOMETRY r73 594
type: Stoichiometry
physical entity: Acetyl CoA
stoichiometric coefficient: 1.0

Protein kinase C beta type
type: ProteinReference
xref: uniprot A8KBH6 459
xref: PTHR24356:SF158
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r73 593
type: Stoichiometry
physical entity: Acetyl CoA
stoichiometric coefficient: 1.0

uniprot A0A2J8J6W3 267
type: UnificationXref
id: A0A2J8J6W3
db: uniprot

GTP s1 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot F6XMN6 477
type: UnificationXref
id: F6XMN6
db: uniprot

G protein alpha q subunit
type: ProteinReference
xref: PTHR10218:SF329
xref: uniprot P23625 366
organism: Drosophila melanogaster

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 308

uniprot F6ZIZ9 324
type: UnificationXref
id: F6ZIZ9
db: uniprot

uniprot F1PLB3 188
type: UnificationXref
id: F1PLB3
db: uniprot

uniprot A5PKD6 286
type: UnificationXref
id: A5PKD6
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot Q14573 58
xref: PTHR13715:SF51
organism: Homo sapiens

STATE_TRANSITION_LEFT__NMDA-RIGHT__NMDA-_r79
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 577
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 578
left: NMDA
interaction type: STATE_TRANSITION
right: NMDA

ncbitaxon 7955 135
type: UnificationXref
id: 7955
db: ncbitaxon

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot Q14571 57
xref: PTHR13715:SF53
organism: Homo sapiens

ncbitaxon 6945 290
type: UnificationXref
id: 6945
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot A0A1D5QIS2 71
organism: Macaca mulatta

uniprot A0A452DI80 200
type: UnificationXref
id: A0A452DI80
db: uniprot

PTHR19957:SF41
type: RelationshipXref
id: PTHR19957:SF41
db: PANTHER Family
relationship type: By Homology

Cholinesterase
type: ProteinReference
xref: uniprot P06276 175
organism: Homo sapiens

uniprot P62879 396
type: UnificationXref
id: P62879
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF240
xref: uniprot Q7QCP8 541
organism: Anopheles gambiae

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot F7BYI4 480
organism: Macaca mulatta

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Muscarinic acetylcholine receptor
type: ProteinReference
xref: PTHR24248:SF153
xref: uniprot F1NMN4 202
organism: Gallus gallus

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot H2Q995 94
xref: PTHR19305:SF4
organism: Pan troglodytes

Glutamate receptor ionotropic, NMDA 2D
type: ProteinReference
evidence: Evidence 234
evidence: Evidence 239
evidence: Evidence 238
xref: PTHR18966:SF385
xref: uniprot Q03391 250
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot H2QJY5 192
organism: Pan troglodytes

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot G5EDN1 172
organism: Caenorhabditis elegans

uniprot P24583 508
type: UnificationXref
id: P24583
db: uniprot

uniprot P60880 117
type: UnificationXref
id: P60880
db: uniprot

Guanine nucleotide-binding protein (G protein), beta 5
type: ProteinReference
xref: uniprot F7EBE7 331
organism: Xenopus tropicalis

ACh
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa9 562
cellular location: synaptic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P16520 361
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6V461 319
organism: Ornithorhynchus anatinus

uniprot A4IGZ2 285
type: UnificationXref
id: A4IGZ2
db: uniprot

uniprot F6Y3N2 322
type: UnificationXref
id: F6Y3N2
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 141

uniprot P28867 510
type: UnificationXref
id: P28867
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6PBR4 430
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DGZ5 426
organism: Danio rerio

GTP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7EG64 483
type: UnificationXref
id: F7EG64
db: uniprot

uniprot H2QLZ4 48
type: UnificationXref
id: H2QLZ4
db: uniprot

uniprot Q92356 150
type: UnificationXref
id: Q92356
db: uniprot

Choline O-acetyltransferase
type: ProteinReference
xref: uniprot Q03059 29
xref: PTHR22589:SF14
organism: Mus musculus

Vesicle associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot A0A2I3SR99 73
organism: Pan troglodytes

uniprot Q05655 528
type: UnificationXref
id: Q05655
db: uniprot

uniprot Q00961 247
type: UnificationXref
id: Q00961
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A0A1D5QYR9 72
xref: PTHR19305:SF4
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r22 581
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot Q6PBN9 429
type: UnificationXref
id: Q6PBN9
db: uniprot

PARTICIPANT STOICHIOMETRY r22 582
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot Q03391 250
type: UnificationXref
id: Q03391
db: uniprot

ncbitaxon 10090 30
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot Q3SZ98 414
type: UnificationXref
id: Q3SZ98
db: uniprot

uniprot H2Q3W7 348
type: UnificationXref
id: H2Q3W7
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__choline-_Acetyl_CoA-RIGHT__ACh-_r56
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 614
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 615
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 613
left: Acetyl CoA
left: choline
interaction type: HETERODIMER_ASSOCIATION
right: ACh

ncbitaxon 9544 18
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot Q7Q6D4 437
type: UnificationXref
id: Q7Q6D4
db: uniprot

uniprot P61264 118
type: UnificationXref
id: P61264
db: uniprot

uniprot P06276 175
type: UnificationXref
id: P06276
db: uniprot

STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_r75
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 587
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 588
left: PLC
interaction type: STATE_TRANSITION
right: PLC

PTHR45816:SF3
type: RelationshipXref
id: PTHR45816:SF3
db: PANTHER Family
relationship type: By Homology

Solute carrier family 5 member 7
type: ProteinReference
xref: PTHR45897:SF2
xref: uniprot E2RAJ0 269
organism: Canis lupus familiaris

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot F6TQN3 190
organism: Monodelphis domestica

uniprot P32749 180
type: UnificationXref
id: P32749
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot F7FXA9 336
organism: Macaca mulatta

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot P29387 368
organism: Mus musculus

PTHR18966:SF407
type: RelationshipXref
id: PTHR18966:SF407
db: PANTHER Family
relationship type: By Homology

ncbitaxon 7165 33
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot F6TQT6 475
type: UnificationXref
id: F6TQT6
db: uniprot

uniprot H2QSU0 49
type: UnificationXref
id: H2QSU0
db: uniprot

PTHR18966:SF400
type: RelationshipXref
id: PTHR18966:SF400
db: PANTHER Family
relationship type: By Homology

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 415
organism: Danio rerio

Syntaxin-1A
type: ProteinReference
xref: uniprot Q24547 136
xref: PTHR19957:SF41
organism: Drosophila melanogaster

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot H2QLZ4 48
organism: Pan troglodytes

uniprot F6XHP0 320
type: UnificationXref
id: F6XHP0
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 110

uniprot Q5R1P3 257
type: UnificationXref
id: Q5R1P3
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot H2QSU0 49
xref: PTHR13715:SF51
organism: Pan troglodytes

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 22

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 422
organism: Mus musculus

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot Q02956 525
organism: Mus musculus

uniprot Q7QBY8 273
type: UnificationXref
id: Q7QBY8
db: uniprot

uniprot F7CS79 230
type: UnificationXref
id: F7CS79
db: uniprot

AChE
type: ProteinReference
xref: P01067
standard name: acetylcholinesterase
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 1 and 3 signaling pathway.PROTEIN.GENERIC.AChE
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: acetylcholinesterase Synonym: ACHE,AChE Accession: P01067
member entity reference: Acetylcholinesterase
member entity reference: Carboxylic ester hydrolase
member entity reference: Cholinesterase
member entity reference: Acetylcholinesterase 1

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot Q63269 61
xref: PTHR13715:SF51
organism: Rattus norvegicus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot F1R506 472
organism: Danio rerio

PTHR10218:SF213
type: RelationshipXref
id: PTHR10218:SF213
db: PANTHER Family
relationship type: By Homology

uniprot A0A2R8QJ48 452
type: UnificationXref
id: A0A2R8QJ48
db: uniprot

Glutamate receptor ionotropic, NMDA 2A
type: ProteinReference
evidence: Evidence 234
evidence: Evidence 242
evidence: Evidence 238
evidence: Evidence 241
xref: PTHR18966:SF407
xref: uniprot Q12879 252
organism: Homo sapiens

Protein kinase C eta type
type: ProteinReference
xref: uniprot Q64617 538
xref: PTHR24356:SF192
organism: Rattus norvegicus

ncbitaxon 227321 141
type: UnificationXref
id: 227321
db: ncbitaxon

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot Q9Z329 63
xref: PTHR13715:SF53
organism: Mus musculus

uniprot Q7ZUC1 149
type: UnificationXref
id: Q7ZUC1
db: uniprot

uniprot P36582 513
type: UnificationXref
id: P36582
db: uniprot

uniprot F6R543 41
type: UnificationXref
id: F6R543
db: uniprot

uniprot A0A1D5QYR9 72
type: UnificationXref
id: A0A1D5QYR9
db: uniprot

Protein kinase C gamma type
type: ProteinReference
xref: uniprot P63318 516
xref: PTHR24356:SF162
organism: Mus musculus

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P63319 517
organism: Rattus norvegicus

AGAP001506-PA
type: ProteinReference
xref: uniprot Q7PXP3 434
organism: Anopheles gambiae

Guanine nucleotide-binding protein (G protein), alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot Q66JF0 425
organism: Xenopus tropicalis

uniprot K7AE17 354
type: UnificationXref
id: K7AE17
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot F6VHF7 43
xref: PTHR13715:SF52
organism: Xenopus tropicalis

Acetylcholinesterase
type: ProteinReference
xref: uniprot P07140 176
organism: Drosophila melanogaster

uniprot F7AQR3 325
type: UnificationXref
id: F7AQR3
db: uniprot

uniprot Q9DDE3 184
type: UnificationXref
id: Q9DDE3
db: uniprot

Protein kinase C-like 2
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P90980 522
organism: Caenorhabditis elegans

uniprot Q7Q8S4 438
type: UnificationXref
id: Q7Q8S4
db: uniprot

VAChT
type: ProteinReference
xref: P01065
standard name: vesicular acetylcholine transporter
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 1 and 3 signaling pathway.PROTEIN.GENERIC.VAChT
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: vesicular acetylcholine transporter Synonym: CG32848,VAChT Accession: P01065
member entity reference: Vesicular acetylcholine transporter
member entity reference: SLC18A3 isoform 1
member entity reference: AGAP002369-PA

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 423
organism: Mus musculus

uniprot P09216 500
type: UnificationXref
id: P09216
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot Q61017 424
organism: Mus musculus

uniprot F6YLB3 229
type: UnificationXref
id: F6YLB3
db: uniprot

uniprot A0A3Q1N7P8 35
type: UnificationXref
id: A0A3Q1N7P8
db: uniprot

ncbitaxon 243090 275
type: UnificationXref
id: 243090
db: ncbitaxon

mAChR1 3 s6 sa3 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.4633432079864352
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Protein CBR-NMR-1
type: ProteinReference
evidence: Evidence 213
xref: uniprot A8WUE7 219
xref: PTHR18966:SF377
organism: Caenorhabditis briggsae

SLC5A7 isoform 1
type: ProteinReference
xref: uniprot A0A2J8J6W3 267
xref: PTHR45897:SF2
organism: Pan troglodytes

uniprot Q7Q042 540
type: UnificationXref
id: Q7Q042
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot F6ZCW7 46
organism: Monodelphis domestica

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot Q9Z2P6 162
xref: PTHR19305:SF9
organism: Rattus norvegicus

uniprot Q7PXP3 434
type: UnificationXref
id: Q7PXP3
db: uniprot

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q9WUF4 161
xref: PTHR45701:SF7
organism: Rattus norvegicus

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_r78
control type: ACTIVATION
controller: K+ channel

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot Q7QFG0 183
xref: PTHR43918:SF5
organism: Anopheles gambiae

PLC
type: ProteinReference
xref: P01068
standard name: Phospholipase C
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 1 and 3 signaling pathway.PROTEIN.GENERIC.PLC
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Phospholipase C Synonym: PLC Accession: P01068
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4

TRANSPORT_LEFT__Acetyl_CoA-RIGHT__Acetyl_CoA-_r73
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 594
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 593
left: Acetyl CoA
interaction type: TRANSPORT
right: Acetyl CoA

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q5R1X1 142
organism: Pan troglodytes

uniprot Q9UK08 445
type: UnificationXref
id: Q9UK08
db: uniprot

uniprot A4IFL6 284
type: UnificationXref
id: A4IFL6
db: uniprot

Syntaxin 1B
type: ProteinReference
xref: uniprot Q1MTI1 134
xref: PTHR19957:SF334
organism: Danio rerio

uniprot F6YMH2 87
type: UnificationXref
id: F6YMH2
db: uniprot

Muscarinic acetylcholine receptor
type: ProteinReference
xref: PTHR24247:SF183
xref: uniprot A0A1D5Q9F8 198
organism: Macaca mulatta

Evidence 214
type: Evidence
evidence code: ISS
comment: Website http://harvester.embl.de/harvester/Q149/Q14957.htm

synaptic vesicle
type: CellularLocationVocabulary
xref: GO GO:0008021 2

Evidence 215
type: Evidence
evidence code: ISS
comment: Website http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436

Acetyl CoA
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Protein kinase C eta type
type: ProteinReference
xref: uniprot P23298 507
xref: PTHR24356:SF192
organism: Mus musculus

uniprot F7BIC2 479
type: UnificationXref
id: F7BIC2
db: uniprot

Evidence 213
type: Evidence
evidence code: ISS
comment: Website http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm

Evidence 218
type: Evidence
evidence code: ISS
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR3A.html

Uncharacterized protein
type: ProteinReference
evidence: Evidence 213
evidence: Evidence 218
xref: uniprot F6VTB5 228
xref: PTHR18966:SF397
organism: Macaca mulatta

Evidence 216
type: Evidence
evidence code: ISS
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6PBN9 429
organism: Danio rerio

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 44

uniprot A0A1D5Q9F8 198
type: UnificationXref
id: A0A1D5Q9F8
db: uniprot

Glutamate receptor ionotropic, NMDA 3A
type: ProteinReference
evidence: Evidence 263
evidence: Evidence 234
xref: uniprot Q8TCU5 262
xref: PTHR18966:SF397
organism: Homo sapiens

Acetylcholinesterase
type: ProteinReference
xref: uniprot P21836 177
organism: Mus musculus

TRIGGER
type: RelationshipTypeVocabulary

uniprot P63045 127
type: UnificationXref
id: P63045
db: uniprot

uniprot P90980 522
type: UnificationXref
id: P90980
db: uniprot

uniprot A8WUE7 219
type: UnificationXref
id: A8WUE7
db: uniprot

uniprot Q9WUF4 161
type: UnificationXref
id: Q9WUF4
db: uniprot

ncbitaxon 7668 104
type: UnificationXref
id: 7668
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot O14610 356
organism: Homo sapiens

mAChR1/3
type: Protein
entity reference: mAChR1/3
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa3 558
feature: mAChR1 3 s6 sa3 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P62880 397
type: UnificationXref
id: P62880
db: uniprot

uniprot F6UBJ8 80
type: UnificationXref
id: F6UBJ8
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P49177 379
organism: Arabidopsis thaliana

TRANSPORT_LEFT__ACh-RIGHT__ACh-_r74
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 591
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 592
left: ACh
interaction type: TRANSPORT
right: ACh

Muscarinic acetylcholine receptor M1
type: ProteinReference
xref: uniprot P11229 208
xref: PTHR24247:SF182
organism: Homo sapiens

uniprot P17343 362
type: UnificationXref
id: P17343
db: uniprot

uniprot P50150 381
type: UnificationXref
id: P50150
db: uniprot

mAChR1 3 s6 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mAChR1/3
stoichiometric coefficient: 1.0

uniprot P61954 391
type: UnificationXref
id: P61954
db: uniprot

Choline O-acetyltransferase
type: ProteinReference
xref: PTHR22589:SF14
xref: uniprot F1P393 12
organism: Gallus gallus

uniprot P08483 207
type: UnificationXref
id: P08483
db: uniprot

uniprot O35526 102
type: UnificationXref
id: O35526
db: uniprot

Evidence 242
type: Evidence
evidence code: IC
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2B.html

Evidence 241
type: Evidence
evidence code: IC
comment: Website http://kr.expasy.org/cgi-bin/sprot-search-ac?P35436

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 360
organism: Bos taurus

ACh
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Protein kinase C
type: ProteinReference
xref: uniprot E1BMG4 461
xref: PTHR24356:SF181
organism: Bos taurus

uniprot Q9BV40 152
type: UnificationXref
id: Q9BV40
db: uniprot

ncbitaxon 9615 16
type: UnificationXref
id: 9615
db: ncbitaxon

Glutamate ionotropic receptor NMDA type subunit 2A
type: ProteinReference
evidence: Evidence 214
evidence: Evidence 213
evidence: Evidence 215
evidence: Evidence 216
xref: PTHR18966:SF407
xref: uniprot F6YLB3 229
organism: Monodelphis domestica

Protein kinase C eta type
type: ProteinReference
xref: uniprot P24723 509
xref: PTHR24356:SF192
organism: Homo sapiens

Evidence 238
type: Evidence
evidence code: IC
comment: Website http://harvester.embl.de/harvester/Q149/Q14957.htm

Evidence 239
type: Evidence
evidence code: IC
comment: Website http://www.biochem.uni-erlangen.de/MouseDB/db/protein/NR2D.html

uniprot Q6P5Z2 539
type: UnificationXref
id: Q6P5Z2
db: uniprot

uniprot F6QXA9 473
type: UnificationXref
id: F6QXA9
db: uniprot

ncbitaxon 9031 13
type: UnificationXref
id: 9031
db: ncbitaxon

Evidence 234
type: Evidence
evidence code: IC
comment: Website http://bioinformatics.weizmann.ac.il/hotmolecbase/entries/nmda.htm

uniprot P34885 512
type: UnificationXref
id: P34885
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T7 342
organism: Macaca mulatta

eco ECO:0000250 8
type: UnificationXref
id: ECO:0000250
db: eco

Muscarinic acetylcholine receptor
type: ProteinReference
xref: PTHR24247:SF183
xref: uniprot F1PGZ2 203
organism: Canis lupus familiaris

uniprot A8XL40 166
type: UnificationXref
id: A8XL40
db: uniprot

uniprot P33328 112
type: UnificationXref
id: P33328
db: uniprot

uniprot Q17QQ3 133
type: UnificationXref
id: Q17QQ3
db: uniprot

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 4

uniprot Q3T0Y8 139
type: UnificationXref
id: Q3T0Y8
db: uniprot

uniprot E2RHY4 302
type: UnificationXref
id: E2RHY4
db: uniprot

Muscarinic acetylcholine receptor
type: ProteinReference
xref: uniprot F1N5C5 201
xref: PTHR24247:SF182
organism: Bos taurus

uniprot P20309 210
type: UnificationXref
id: P20309
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QUY0 351
organism: Pan troglodytes

Complex (GDP/G-Protein/ mAChR1/3)
type: Complex
component stoichiometry: mAChR1 3 s6 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s5 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s3 sa1 STOICHIOMETRY ID COMPLEX
component: G-Protein
component: mAChR1/3
component: GDP
feature: COMPLEX BINDING FEATURE s58 a64 557
feature: COMPLEX BINDING FEATURE s58 a64 555
feature: COMPLEX BINDING FEATURE s58 a64 553
cellular location: cytosol

Vesicle associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot E2QUL2 76
organism: Canis lupus familiaris

uniprot Q01098 249
type: UnificationXref
id: Q01098
db: uniprot

uniprot P63319 517
type: UnificationXref
id: P63319
db: uniprot

Glutamate ionotropic receptor NMDA type subunit 3A
type: ProteinReference
evidence: Evidence 213
evidence: Evidence 218
xref: PTHR18966:SF397
xref: uniprot E2QUL1 221
organism: Canis lupus familiaris

uniprot P63027 125
type: UnificationXref
id: P63027
db: uniprot

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot F5HH30 313
organism: Neurospora crassa

uniprot F1P3G1 471
type: UnificationXref
id: F1P3G1
db: uniprot

uniprot F7G1U7 338
type: UnificationXref
id: F7G1U7
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P43425 378
organism: Rattus norvegicus

uniprot P23763 108
type: UnificationXref
id: P23763
db: uniprot

uniprot H2Q9G5 349
type: UnificationXref
id: H2Q9G5
db: uniprot

uniprot E1BKE7 37
type: UnificationXref
id: E1BKE7
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IGZ2 285
organism: Xenopus tropicalis

uniprot Q5ZJ03 421
type: UnificationXref
id: Q5ZJ03
db: uniprot

uniprot O70404 105
type: UnificationXref
id: O70404
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot Q02156 524
organism: Homo sapiens

uniprot Q7Q6D3 436
type: UnificationXref
id: Q7Q6D3
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__choline-_CHT1-RIGHT__Complex__CHT1_choline_-_r71
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 599
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 600
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 598
left: CHT1
left: choline
interaction type: HETERODIMER_ASSOCIATION
right: Complex (CHT1/choline)

uniprot A0A2I3SSC7 34
type: UnificationXref
id: A0A2I3SSC7
db: uniprot

ncbitaxon 367110 314
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot E2RNP2 465
type: UnificationXref
id: E2RNP2
db: uniprot

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot H2QNP1 174
xref: PTHR43918:SF5
organism: Pan troglodytes

uniprot A0A3Q1NGS8 283
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

PTHR24351:SF182
type: RelationshipXref
id: PTHR24351:SF182
db: PANTHER Family
relationship type: By Homology

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot E2RMC0 38
xref: PTHR13715:SF51
organism: Canis lupus familiaris

uniprot H9FU38 51
type: UnificationXref
id: H9FU38
db: uniprot

uniprot A0A1D5QEM1 70
type: UnificationXref
id: A0A1D5QEM1
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XWE8 321
organism: Monodelphis domestica

Muscarinic acetylcholine receptor
type: ProteinReference
xref: uniprot H2Q3X5 205
xref: PTHR24247:SF182
organism: Pan troglodytes

P01072
type: UnificationXref
id: P01072
db: PANTHER Pathway Component

P01073
type: UnificationXref
id: P01073
db: PANTHER Pathway Component

NMDA
type: Protein
entity reference: NMDA
feature: NMDA s96 a100 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2J8Q8V8 164
type: UnificationXref
id: A0A2J8Q8V8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VQP7 45
xref: PTHR13715:SF52
organism: Monodelphis domestica

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot P70227 56
xref: PTHR13715:SF51
organism: Mus musculus

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot Q92356 150
organism: Schizosaccharomyces pombe

PTHR18966:SF497
type: RelationshipXref
id: PTHR18966:SF497
db: PANTHER Family
relationship type: By Homology

P01071
type: UnificationXref
id: P01071
db: PANTHER Pathway Component

P01074
type: UnificationXref
id: P01074
db: PANTHER Pathway Component

Protein kinase C-like 1
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P24583 508
organism: Saccharomyces cerevisiae

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: PTHR45816:SF3
xref: uniprot A0A3Q1N7P8 35
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
evidence: Evidence 213
evidence: Evidence 216
xref: PTHR18966:SF382
xref: uniprot F1NMB0 224
organism: Gallus gallus

AGAP005911-PA
type: ProteinReference
xref: uniprot Q7Q6D4 437
organism: Anopheles gambiae

PTHR24356:SF240
type: RelationshipXref
id: PTHR24356:SF240
db: PANTHER Family
relationship type: By Homology

AGAP005913-PA
type: ProteinReference
xref: uniprot Q7Q6D2 435
organism: Anopheles gambiae

AGAP005912-PA
type: ProteinReference
xref: uniprot Q7Q6D3 436
organism: Anopheles gambiae

uniprot K6ZCJ5 353
type: UnificationXref
id: K6ZCJ5
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 11

Glutamate receptor ionotropic, NMDA 2C
type: ProteinReference
evidence: Evidence 234
evidence: Evidence 238
xref: uniprot Q01098 249
xref: PTHR18966:SF361
organism: Mus musculus

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 234
evidence: Evidence 242
xref: PTHR18966:SF382
xref: uniprot Q01097 248
organism: Mus musculus

uniprot H2QAS6 488
type: UnificationXref
id: H2QAS6
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 84

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q3W7 348
organism: Pan troglodytes

uniprot F6RA79 474
type: UnificationXref
id: F6RA79
db: uniprot

P01063
type: UnificationXref
id: P01063
db: PANTHER Pathway Component

P01064
type: UnificationXref
id: P01064
db: PANTHER Pathway Component

P01065
type: UnificationXref
id: P01065
db: PANTHER Pathway Component

P01066
type: UnificationXref
id: P01066
db: PANTHER Pathway Component

P01067
type: UnificationXref
id: P01067
db: PANTHER Pathway Component

P01068
type: UnificationXref
id: P01068
db: PANTHER Pathway Component

uniprot G2HIJ9 92
type: UnificationXref
id: G2HIJ9
db: uniprot

P01069
type: UnificationXref
id: P01069
db: PANTHER Pathway Component

PTHR24356:SF246
type: RelationshipXref
id: PTHR24356:SF246
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q28H40 412
organism: Xenopus tropicalis

uniprot F1A421 307
type: UnificationXref
id: F1A421
db: uniprot

uniprot E2RBE7 300
type: UnificationXref
id: E2RBE7
db: uniprot

uniprot F1PJE5 311
type: UnificationXref
id: F1PJE5
db: uniprot

Glutamate receptor ionotropic, NMDA 2D
type: ProteinReference
evidence: Evidence 234
evidence: Evidence 239
evidence: Evidence 238
xref: PTHR18966:SF385
xref: uniprot O15399 237
organism: Homo sapiens

uniprot F7DVL1 482
type: UnificationXref
id: F7DVL1
db: uniprot

PTHR24356:SF210
type: RelationshipXref
id: PTHR24356:SF210
db: PANTHER Family
relationship type: By Homology

uniprot Q0VFC4 407
type: UnificationXref
id: Q0VFC4
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P30671 371
organism: Bos taurus

uniprot Q01097 248
type: UnificationXref
id: Q01097
db: uniprot

uniprot F7ECA6 332
type: UnificationXref
id: F7ECA6
db: uniprot

uniprot Q9QW07 197
type: UnificationXref
id: Q9QW07
db: uniprot

uniprot F6VT32 476
type: UnificationXref
id: F6VT32
db: uniprot

Muscarinic acetylcholine receptor M1
type: ProteinReference
xref: uniprot P08482 206
xref: PTHR24247:SF182
organism: Rattus norvegicus

uniprot P35439 244
type: UnificationXref
id: P35439
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 290

Muscarinic acetylcholine receptor M3
type: ProteinReference
xref: PTHR24247:SF183
xref: uniprot P08483 207
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A818 47
xref: PTHR13715:SF53
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NMDA-RIGHT__NMDA-_r79
controller: PKC

PARTICIPANT STOICHIOMETRY r69 603
type: Stoichiometry
physical entity: Complex (VAChT/ACh)
stoichiometric coefficient: 1.0

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot A0A2I3SR38 451
organism: Pan troglodytes

PTHR24356:SF214
type: RelationshipXref
id: PTHR24356:SF214
db: PANTHER Family
relationship type: By Homology

uniprot Q9WTQ0 548
type: UnificationXref
id: Q9WTQ0
db: uniprot

uniprot H2QUY0 351
type: UnificationXref
id: H2QUY0
db: uniprot

PARTICIPANT STOICHIOMETRY r69 601
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r69 602
type: Stoichiometry
physical entity: VAChT
stoichiometric coefficient: 1.0

uniprot P63077 399
type: UnificationXref
id: P63077
db: uniprot

uniprot Q9ERB0 153
type: UnificationXref
id: Q9ERB0
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot F1A421 307
organism: Dictyostelium purpureum

uniprot H8WGV2 50
type: UnificationXref
id: H8WGV2
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 16

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot Q08BT6 529
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NGS8 283
organism: Bos taurus

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 350
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7G7I9 340
organism: Ornithorhynchus anatinus

VAMP3 isoform 1
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot G2HIJ9 92
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TQT6 475
xref: PTHR24356:SF246
organism: Macaca mulatta

PTHR45701:SF10
type: RelationshipXref
id: PTHR45701:SF10
db: PANTHER Family
relationship type: By Homology

uniprot Q63666 146
type: UnificationXref
id: Q63666
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot E2R907 77
organism: Canis lupus familiaris

uniprot O95721 106
type: UnificationXref
id: O95721
db: uniprot

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot P30677 372
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7CFG8 327
organism: Monodelphis domestica

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 13

uniprot Q13224 253
type: UnificationXref
id: Q13224
db: uniprot

uniprot F6V461 319
type: UnificationXref
id: F6V461
db: uniprot

NMDA
type: ProteinReference
xref: P01071
standard name: N-methyl-D-aspartate Receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 1 and 3 signaling pathway.PROTEIN.ION_CHANNEL.NMDA
comment: ENTITY_REFERENCE_NOTES= Long Name: N-methyl-D-aspartate Receptor Synonym: NMDA,NMDA Receptor Accession: P01071
member entity reference: Glutamate receptor ionotropic, NMDA 1
member entity reference: Glutamate ionotropic receptor NMDA type subunit 1
member entity reference: N-methyl-D-aspartate receptor type 1 subunit
member entity reference: Glutamate receptor, ionotropic, N-methyl D-aspartate 1a
member entity reference: Glutamate ionotropic receptor NMDA type subunit 3A
member entity reference: Uncharacterized protein
member entity reference: Glutamate receptor ionotropic, NMDA 2B
member entity reference: Glutamate receptor ionotropic, NMDA 2C
member entity reference: Glutamate receptor ionotropic, NMDA 2A
member entity reference: Glutamate receptor ionotropic, NMDA 3B
member entity reference: Glutamate receptor ionotropic, NMDA 3A
member entity reference: GRIN2B isoform 3
member entity reference: Glutamate receptor ionotropic, NMDA3A
member entity reference: Glutamate receptor ionotropic, NMDA 2D
member entity reference: NMDA class glutamate Receptor
member entity reference: AGAP001478-PA
member entity reference: Protein CBR-NMR-1
member entity reference: Glutamate ionotropic receptor NMDA type subunit 2A
member entity reference: N-methyl D-aspartate receptor subtype 2B
member entity reference: NMDA receptor 2, isoform C
member entity reference: Glutamate receptor, ionotropic, N-methyl D-aspartate 1b
member entity reference: Glutamate [NMDA] receptor subunit 1
member entity reference: Glutamate [NMDA] receptor subunit zeta-1 isoform NR1-3

uniprot Q5F3B5 418
type: UnificationXref
id: Q5F3B5
db: uniprot

uniprot Q16512 530
type: UnificationXref
id: Q16512
db: uniprot

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q02111 523
xref: PTHR24356:SF181
organism: Mus musculus

Acetylcholinesterase 1
type: ProteinReference
xref: uniprot P38433 181
organism: Caenorhabditis elegans

uniprot F6ZCW7 46
type: UnificationXref
id: F6ZCW7
db: uniprot

uniprot P87253 521
type: UnificationXref
id: P87253
db: uniprot

uniprot P13217 194
type: UnificationXref
id: P13217
db: uniprot

GDP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot Q5PU49 535
organism: Canis lupus familiaris

uniprot F7HUF6 204
type: UnificationXref
id: F7HUF6
db: uniprot

Syntaxin-1B
type: ProteinReference
xref: uniprot P61265 119
xref: PTHR19957:SF334
organism: Rattus norvegicus

Inositol 1,4,5-trisphosphate receptor type 1 isoform 3
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot H9FU38 51
organism: Macaca mulatta

Syntaxin-1B
type: ProteinReference
xref: PTHR19957:SF334
xref: uniprot P61264 118
organism: Mus musculus

Glutamate receptor ionotropic, NMDA 2D
type: ProteinReference
evidence: Evidence 234
evidence: Evidence 239
evidence: Evidence 238
xref: PTHR18966:SF385
xref: uniprot Q62645 258
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot P21278 364
xref: PTHR10218:SF328
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7GI54 341
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot F7ECA6 332
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot P21279 365
organism: Mus musculus

uniprot F1PXS6 225
type: UnificationXref
id: F1PXS6
db: uniprot

uniprot P29387 368
type: UnificationXref
id: P29387
db: uniprot

ACTIVE 64
type: EntityFeature
comment: Active state

Complex (GTP/G-Protein)
type: Complex
component stoichiometry: G Protein s2 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s1 sa4 STOICHIOMETRY ID COMPLEX
component: G-Protein
component: GTP
feature: COMPLEX BINDING FEATURE s59 a65 551
feature: ACTIVE 64
feature: COMPLEX BINDING FEATURE s59 a65 549
cellular location: cytosol

eco ECO:0000305 14
type: UnificationXref
id: ECO:0000305
db: eco

SNAP25 homologous protein SNAP33
type: ProteinReference
xref: uniprot Q9S7P9 157
organism: Arabidopsis thaliana

uniprot Q6PC54 147
type: UnificationXref
id: Q6PC54
db: uniprot

uniprot P09217 501
type: UnificationXref
id: P09217
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot Q9VH76 159
xref: PTHR19305:SF14
organism: Drosophila melanogaster

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot F1PLB3 188
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit gamma-1
type: ProteinReference
xref: uniprot P38040 375
organism: Drosophila melanogaster

PTHR19957:SF84
type: RelationshipXref
id: PTHR19957:SF84
db: PANTHER Family
relationship type: By Homology

GDP s3 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Gnb3 protein
type: ProteinReference
xref: uniprot Q6P025 428
organism: Danio rerio

uniprot F7FXA9 336
type: UnificationXref
id: F7FXA9
db: uniprot

uniprot A0A2I3SR38 451
type: UnificationXref
id: A0A2I3SR38
db: uniprot

uniprot Q2KJD2 138
type: UnificationXref
id: Q2KJD2
db: uniprot

Glutamate receptor, ionotropic, N-methyl D-aspartate 1a
type: ProteinReference
evidence: Evidence 213
xref: PTHR18966:SF400
xref: uniprot E7F101 222
organism: Danio rerio

uniprot F6YZA3 323
type: UnificationXref
id: F6YZA3
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P68404 518
organism: Mus musculus

uniprot P11881 52
type: UnificationXref
id: P11881
db: uniprot

uniprot G5EDN1 172
type: UnificationXref
id: G5EDN1
db: uniprot

N-methyl-D-aspartate receptor type 1 subunit
type: ProteinReference
evidence: Evidence 234
xref: uniprot Q6R6I2 259
xref: PTHR18966:SF377
organism: Gallus gallus

uniprot Q90XF2 547
type: UnificationXref
id: Q90XF2
db: uniprot

uniprot P62874 395
type: UnificationXref
id: P62874
db: uniprot

uniprot A1Z7T0 457
type: UnificationXref
id: A1Z7T0
db: uniprot

Guanine nucleotide binding protein, beta subunit
type: ProteinReference
xref: uniprot E9FUX0 304
organism: Daphnia pulex

uniprot P16054 504
type: UnificationXref
id: P16054
db: uniprot

uniprot Q03311 182
type: UnificationXref
id: Q03311
db: uniprot

uniprot F6QHN1 270
type: UnificationXref
id: F6QHN1
db: uniprot

Carboxylic ester hydrolase
type: ProteinReference
xref: PTHR43918:SF4
xref: uniprot A8XL40 166
organism: Caenorhabditis briggsae

Complex (VAChT/ACh)
type: Complex
component stoichiometry: VAChT s9 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: ACh s10 sa9 STOICHIOMETRY ID COMPLEX
component: ACh
component: VAChT
feature: COMPLEX BINDING FEATURE s88 a94 559
feature: COMPLEX BINDING FEATURE s88 a94 561
cellular location: synaptic vesicle

IP3R
type: ProteinReference
xref: P01064
standard name: inositol 1,4,5-triphosphate receptor 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 1 and 3 signaling pathway.PROTEIN.ION_CHANNEL.IP_sub_3_endsub_R
comment: ENTITY_REFERENCE_NOTES= Long Name: inositol 1,4,5-triphosphate receptor 1 Synonym: ITPR1 Accession: P01064
member entity reference: Uncharacterized protein
member entity reference: Inositol 1,4,5-trisphosphate receptor type 2
member entity reference: Inositol 1,4,5-trisphosphate receptor type 3
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1 isoform 3
member entity reference: AGAP006475-PA
member entity reference: Inositol 1,4,5-trisphosphate receptor itr-1
member entity reference: Inositol 1,4,5-trisphosphate receptor
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1
member entity reference: Protein CBR-ITR-1, isoform a

Guanine nucleotide-binding protein (G protein), q polypeptide
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot Q28FH0 411
organism: Xenopus tropicalis

uniprot Q5ANK2 533
type: UnificationXref
id: Q5ANK2
db: uniprot

uniprot F7CTP1 328
type: UnificationXref
id: F7CTP1
db: uniprot

uniprot P34722 511
type: UnificationXref
id: P34722
db: uniprot

Syntaxin-1B
type: ProteinReference
xref: uniprot P61266 120
xref: PTHR19957:SF334
organism: Homo sapiens

Syntaxin-1B
type: ProteinReference
xref: uniprot P61267 121
xref: PTHR19957:SF334
organism: Bos taurus

uniprot P05129 496
type: UnificationXref
id: P05129
db: uniprot

uniprot Q20636 410
type: UnificationXref
id: Q20636
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 213
evidence: Evidence 216
xref: PTHR18966:SF382
xref: uniprot F1MCL3 223
organism: Bos taurus

uniprot Q9Z329 63
type: UnificationXref
id: Q9Z329
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F7DVL1 482
xref: PTHR24356:SF214
organism: Xenopus tropicalis

uniprot Q7PXM3 261
type: UnificationXref
id: Q7PXM3
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot H2QAS6 488
organism: Pan troglodytes

STX1A isoform 3
type: ProteinReference
xref: PTHR19957:SF84
xref: uniprot H2QUQ1 96
organism: Pan troglodytes

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot Q5ANK2 533
organism: Candida albicans

Vesicular acetylcholine transporter
type: ProteinReference
xref: uniprot Q62666 68
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 316
organism: Monodelphis domestica

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot E1BQN6 462
organism: Gallus gallus

uniprot Q5EAP4 417
type: UnificationXref
id: Q5EAP4
db: uniprot

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot F7AQR3 325
organism: Macaca mulatta

uniprot Q28HP6 137
type: UnificationXref
id: Q28HP6
db: uniprot

uniprot P12657 209
type: UnificationXref
id: P12657
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 322
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r75 587
type: Stoichiometry
physical entity: PLC
stoichiometric coefficient: 1.0

THO complex subunit, putative
type: ProteinReference
xref: uniprot B7Q3T6 289
organism: Ixodes scapularis

PARTICIPANT STOICHIOMETRY r75 588
type: Stoichiometry
physical entity: PLC
stoichiometric coefficient: 1.0

GO GO:0043679 3
type: UnificationXref
id: GO:0043679
db: GO

uniprot E2QUL2 76
type: UnificationXref
id: E2QUL2
db: uniprot

Glutamate receptor, ionotropic, N-methyl D-aspartate 1b
type: ProteinReference
evidence: Evidence 213
xref: uniprot Q6ZM67 260
xref: PTHR18966:SF497
organism: Danio rerio

uniprot Q9N0Y0 156
type: UnificationXref
id: Q9N0Y0
db: uniprot

Serine/threonine-protein kinase N2
type: ProteinReference
xref: PTHR24356:SF322
xref: uniprot Q8BWW9 545
organism: Mus musculus

uniprot F6UFJ7 81
type: UnificationXref
id: F6UFJ7
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XHP0 320
organism: Macaca mulatta

uniprot F7H3B3 484
type: UnificationXref
id: F7H3B3
db: uniprot

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__choline-_Acetyl_CoA-RIGHT__ACh-_r56
controller: CAT

Protein kinase C eta type
type: ProteinReference
xref: uniprot H2Q8F2 487
xref: PTHR24356:SF192
organism: Pan troglodytes

SLC18A3 isoform 1
type: ProteinReference
xref: uniprot H2Q1W2 65
xref: PTHR23506:SF13
organism: Pan troglodytes

Complex (mAChR1/3/ ACh)
type: Complex
component stoichiometry: ACh s8 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: mAChR1 3 s7 sa6 STOICHIOMETRY ID COMPLEX
component: mAChR1/3
component: ACh
feature: COMPLEX BINDING FEATURE s65 a73 569
feature: COMPLEX BINDING FEATURE s65 a73 567
cellular location: cytosol

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot O95837 359
organism: Homo sapiens

uniprot E2R9G5 299
type: UnificationXref
id: E2R9G5
db: uniprot

VAChT
type: Protein
entity reference: VAChT
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

Syntaxin-1A isoform 1
type: ProteinReference
xref: uniprot A0A1D5QEM1 70
xref: PTHR19957:SF84
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2UD13 36
xref: PTHR13715:SF52
organism: Gallus gallus

Protein CBR-CHA-1
type: ProteinReference
xref: uniprot A8X694 6
xref: PTHR23506:SF23
organism: Caenorhabditis briggsae

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05771 498
xref: PTHR24356:SF158
organism: Homo sapiens

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P26308 367
organism: Drosophila melanogaster

uniprot P63216 403
type: UnificationXref
id: P63216
db: uniprot

uniprot P63219 406
type: UnificationXref
id: P63219
db: uniprot

By Homology
type: RelationshipTypeVocabulary

CHT1
type: Protein
entity reference: CHT1
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa10 564
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

PTHR11559:SF397
type: RelationshipXref
id: PTHR11559:SF397
db: PANTHER Family
relationship type: By Homology

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot A0A1D5R985 448
organism: Macaca mulatta

uniprot F7A943 89
type: UnificationXref
id: F7A943
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CXD0 329
organism: Monodelphis domestica

uniprot P35436 240
type: UnificationXref
id: P35436
db: uniprot

uniprot Q5XGD8 420
type: UnificationXref
id: Q5XGD8
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot F6VM87 82
organism: Monodelphis domestica

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot P28867 510
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot E2RNP2 465
organism: Canis lupus familiaris

uniprot C3ZRW7 169
type: UnificationXref
id: C3ZRW7
db: uniprot

uniprot P23795 179
type: UnificationXref
id: P23795
db: uniprot

DISSOCIATION_LEFT__Complex__CHT1_choline_-RIGHT__choline-_CHT1-_r72
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 596
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 595
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 597
left: Complex (CHT1/choline)
interaction type: DISSOCIATION
right: CHT1
right: choline

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5F3B5 418
xref: PTHR10218:SF316
organism: Gallus gallus

mAChR1/3
type: Protein
entity reference: mAChR1/3
feature: mAChR1 3 s7 sa6 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa6 568
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 33

Protein kinase C
type: ProteinReference
xref: uniprot F7A632 478
xref: PTHR24356:SF158
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 309
organism: Bos taurus

uniprot P29994 54
type: UnificationXref
id: P29994
db: uniprot

uniprot E9FUX0 304
type: UnificationXref
id: E9FUX0
db: uniprot

uniprot P63218 405
type: UnificationXref
id: P63218
db: uniprot

NMDA
type: Protein
entity reference: NMDA
feature: NMDA s50 a55 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q16513 531
type: UnificationXref
id: Q16513
db: uniprot

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot Q9U295 186
organism: Caenorhabditis elegans

K+ channel
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Choline O-acetyltransferase
type: ProteinReference
xref: uniprot P32738 25
xref: PTHR22589:SF14
organism: Rattus norvegicus

Synaptosomal-associated protein 23
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot O09044 101
organism: Mus musculus

uniprot Q5TX47 143
type: UnificationXref
id: Q5TX47
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7BB02 326
organism: Macaca mulatta

uniprot F6VQP7 45
type: UnificationXref
id: F6VQP7
db: uniprot

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 439
organism: Danio rerio

uniprot Q6PH57 432
type: UnificationXref
id: Q6PH57
db: uniprot

uniprot F8W3G9 343
type: UnificationXref
id: F8W3G9
db: uniprot

mAChR1 3 s7 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mAChR1/3
stoichiometric coefficient: 1.0

uniprot A1Z9X0 458
type: UnificationXref
id: A1Z9X0
db: uniprot

Vesicular acetylcholine transporter
type: ProteinReference
xref: uniprot Q16572 67
organism: Homo sapiens

uniprot Q10282 408
type: UnificationXref
id: Q10282
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot A8X8S6 75
organism: Caenorhabditis briggsae

Glutamate ionotropic receptor NMDA type subunit 1
type: ProteinReference
evidence: Evidence 213
xref: uniprot G3N3K3 232
xref: PTHR18966:SF377
organism: Bos taurus

uniprot F1NMN4 202
type: UnificationXref
id: F1NMN4
db: uniprot

Cholinesterase
type: ProteinReference
xref: uniprot P32749 180
xref: PTHR43918:SF5
organism: Bos taurus

uniprot Q14571 57
type: UnificationXref
id: Q14571
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q63666 146
organism: Rattus norvegicus

uniprot Q14643 59
type: UnificationXref
id: Q14643
db: uniprot

K+ channel
type: Protein
feature: ACTIVE 64
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot E9GJ31 306
type: UnificationXref
id: E9GJ31
db: uniprot

uniprot F1NLV4 310
type: UnificationXref
id: F1NLV4
db: uniprot

uniprot A8WQR8 268
type: UnificationXref
id: A8WQR8
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot Q7SZZ5 148
organism: Danio rerio

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot P16054 504
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3KRE3 413
organism: Rattus norvegicus

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot F7EG64 483
organism: Xenopus tropicalis

ACh
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

High affinity choline transporter 1
type: ProteinReference
xref: uniprot Q8BGY9 276
organism: Mus musculus

ACh s8 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

G protein subunit beta 5
type: ProteinReference
xref: uniprot E2RHY4 302
organism: Canis lupus familiaris

uniprot P38040 375
type: UnificationXref
id: P38040
db: uniprot

uniprot P68404 518
type: UnificationXref
id: P68404
db: uniprot

uniprot O15399 237
type: UnificationXref
id: O15399
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot F1P3G1 471
organism: Gallus gallus

High affinity choline transporter
type: ProteinReference
xref: PTHR48086:SF7
xref: uniprot Q7UFM6 274
organism: Rhodopirellula baltica

uniprot Q61011 422
type: UnificationXref
id: Q61011
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot O60262 358
organism: Homo sapiens

Choline O-acetyltransferase
type: ProteinReference
xref: uniprot P32756 27
xref: PTHR22589:SF14
organism: Caenorhabditis elegans

uniprot E2RAJ0 269
type: UnificationXref
id: E2RAJ0
db: uniprot

uniprot O44419 103
type: UnificationXref
id: O44419
db: uniprot

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot Q2KI26 272
type: UnificationXref
id: Q2KI26
db: uniprot

ACh
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa7 570
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot D3ZLD6 293
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r77 583
type: Stoichiometry
physical entity: K+ channel
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r77 584
type: Stoichiometry
physical entity: K+ channel
stoichiometric coefficient: 1.0

G Protein s5 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

uniprot E1BA29 294
type: UnificationXref
id: E1BA29
db: uniprot

uniprot F7ES96 334
type: UnificationXref
id: F7ES96
db: uniprot

uniprot Q15147 195
type: UnificationXref
id: Q15147
db: uniprot

uniprot P62871 392
type: UnificationXref
id: P62871
db: uniprot

uniprot P11017 360
type: UnificationXref
id: P11017
db: uniprot

PTHR19305:SF5
type: RelationshipXref
id: PTHR19305:SF5
db: PANTHER Family
relationship type: By Homology

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 151

PTHR19305:SF9
type: RelationshipXref
id: PTHR19305:SF9
db: PANTHER Family
relationship type: By Homology

uniprot G5EGU1 345
type: UnificationXref
id: G5EGU1
db: uniprot

uniprot A8KBH6 459
type: UnificationXref
id: A8KBH6
db: uniprot

uniprot F6VUT7 83
type: UnificationXref
id: F6VUT7
db: uniprot

DISSOCIATION_LEFT__Complex__VAChT_ACh_-RIGHT__ACh-_VAChT-_r70
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 606
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 605
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 604
left: Complex (VAChT/ACh)
interaction type: DISSOCIATION
right: VAChT
right: ACh

uniprot Q62074 536
type: UnificationXref
id: Q62074
db: uniprot

SNARE COMPLEX
type: Protein
entity reference: SNARE COMPLEX
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot Q14573 58
type: UnificationXref
id: Q14573
db: uniprot

uniprot F6THW2 318
type: UnificationXref
id: F6THW2
db: uniprot

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 234
xref: uniprot Q05586 251
xref: PTHR18966:SF377
organism: Homo sapiens

uniprot P83351 128
type: UnificationXref
id: P83351
db: uniprot

uniprot F6PGX6 226
type: UnificationXref
id: F6PGX6
db: uniprot

PTHR19305:SF4
type: RelationshipXref
id: PTHR19305:SF4
db: PANTHER Family
relationship type: By Homology

uniprot Q5TQX0 60
type: UnificationXref
id: Q5TQX0
db: uniprot

DISSOCIATION
type: InteractionVocabulary

uniprot E1BQN6 462
type: UnificationXref
id: E1BQN6
db: uniprot

Protein kinase C-like
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P87253 521
organism: Neurospora crassa

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q0VFC4 407
organism: Xenopus tropicalis

Glutamate receptor ionotropic, NMDA 3B
type: ProteinReference
evidence: Evidence 263
evidence: Evidence 234
xref: PTHR18966:SF364
xref: uniprot Q91ZU9 265
organism: Mus musculus

uniprot F1MYW8 309
type: UnificationXref
id: F1MYW8
db: uniprot

uniprot Q14957 254
type: UnificationXref
id: Q14957
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6TH03 433
organism: Danio rerio

uniprot E2RJB3 303
type: UnificationXref
id: E2RJB3
db: uniprot

mAChR1/3
type: ProteinReference
xref: P01069
standard name: Muscarinic acetylcholine receptor 1 and 3
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 1 and 3 signaling pathway.PROTEIN.RECEPTOR.mAChR1/3
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Cholinergic receptor muscarinic 3
member entity reference: Muscarinic acetylcholine receptor
member entity reference: Muscarinic acetylcholine receptor M3
member entity reference: Muscarinic acetylcholine receptor M1

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot Q20636 410
organism: Caenorhabditis elegans

uniprot Q9ERZ3 211
type: UnificationXref
id: Q9ERZ3
db: uniprot

GNB4 protein
type: ProteinReference
xref: uniprot A5PKD6 286
organism: Bos taurus

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 24

PLC
type: Protein
entity reference: PLC
feature: ACTIVE 64
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P63215 402
type: UnificationXref
id: P63215
db: uniprot

Serine/threonine-protein kinase N1
type: ProteinReference
xref: uniprot Q63433 537
xref: PTHR24356:SF246
organism: Rattus norvegicus

uniprot F7GI54 341
type: UnificationXref
id: F7GI54
db: uniprot

uniprot F7DNS6 90
type: UnificationXref
id: F7DNS6
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q28HP6 137
organism: Xenopus tropicalis

K+
type: SmallMolecule
comment: SPECIES_TYPE=ION

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot F1MX21 39
xref: PTHR13715:SF52
organism: Bos taurus

uniprot Q91ZU9 265
type: UnificationXref
id: Q91ZU9
db: uniprot

uniprot F6T8S6 227
type: UnificationXref
id: F6T8S6
db: uniprot

uniprot P61952 389
type: UnificationXref
id: P61952
db: uniprot

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 104

uniprot Q9W581 266
type: UnificationXref
id: Q9W581
db: uniprot

uniprot P54313 387
type: UnificationXref
id: P54313
db: uniprot

uniprot F6Z5I2 88
type: UnificationXref
id: F6Z5I2
db: uniprot

Glutamate [NMDA] receptor subunit zeta-1 isoform NR1-3
type: ProteinReference
evidence: Evidence 213
xref: PTHR18966:SF377
xref: uniprot F7GR67 231
organism: Macaca mulatta

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E1C795 296
organism: Gallus gallus

PIP2
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q6DH55 427
type: UnificationXref
id: Q6DH55
db: uniprot

uniprot H2Q8F2 487
type: UnificationXref
id: H2Q8F2
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot R4GKD1 447
organism: Gallus gallus

uniprot H2QUQ1 96
type: UnificationXref
id: H2QUQ1
db: uniprot

Muscarinic acetylcholine receptor M3
type: ProteinReference
xref: uniprot P20309 210
xref: PTHR24247:SF183
organism: Homo sapiens

CHT1
type: Protein
entity reference: CHT1
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

AGAP010589-PA
type: ProteinReference
xref: uniprot Q7Q8S4 438
organism: Anopheles gambiae

Atypical protein kinase C
type: ProteinReference
xref: PTHR24356:SF303
xref: uniprot A1Z9X0 458
organism: Drosophila melanogaster

Carboxylic ester hydrolase
type: ProteinReference
xref: PTHR11559:SF397
xref: uniprot C3ZD75 167
organism: Branchiostoma floridae

uniprot F1P393 12
type: UnificationXref
id: F1P393
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 334
organism: Macaca mulatta

ncbitaxon 10116 26
type: UnificationXref
id: 10116
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NLV4 310
organism: Gallus gallus

uniprot Q0VFR6 130
type: UnificationXref
id: Q0VFR6
db: uniprot

uniprot E2RGI5 301
type: UnificationXref
id: E2RGI5
db: uniprot

ncbitaxon 9913 11
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot O09044 101
type: UnificationXref
id: O09044
db: uniprot

Guanine nucleotide-binding protein (G protein), q polypeptide
type: ProteinReference
xref: uniprot B8JLJ7 291
xref: PTHR10218:SF316
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V8K2 344
organism: Rattus norvegicus

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot P31109 109
organism: Saccharomyces cerevisiae

uniprot Q02111 523
type: UnificationXref
id: Q02111
db: uniprot

uniprot Q9VE46 279
type: UnificationXref
id: Q9VE46
db: uniprot

uniprot Q62645 258
type: UnificationXref
id: Q62645
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot Q7T2C5 543
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r46 590
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot A7EDU2 287
organism: Sclerotinia sclerotiorum

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot P54406 388
organism: Caenorhabditis elegans

uniprot F7BB02 326
type: UnificationXref
id: F7BB02
db: uniprot

uniprot E2RP98 170
type: UnificationXref
id: E2RP98
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 213
evidence: Evidence 216
xref: PTHR18966:SF382
xref: uniprot F6PGX6 226
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r46 589
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

uniprot P23298 507
type: UnificationXref
id: P23298
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q17499 31
organism: Caenorhabditis elegans

SNAP29 isoform 1
type: ProteinReference
xref: uniprot H2QLA1 95
xref: PTHR19305:SF9
organism: Pan troglodytes

uniprot F1MFK1 468
type: UnificationXref
id: F1MFK1
db: uniprot

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__PIP2-RIGHT__DAG-_IP3-_r8
controller: PLC

uniprot Q05513 527
type: UnificationXref
id: Q05513
db: uniprot

uniprot H2QZZ2 236
type: UnificationXref
id: H2QZZ2
db: uniprot

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q9WTQ0 548
organism: Rattus norvegicus

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 374

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F2Z3T8 312
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot Q90Z40 441
type: UnificationXref
id: Q90Z40
db: uniprot

Glutamate ionotropic receptor NMDA type subunit 1
type: ProteinReference
evidence: Evidence 213
xref: uniprot F7CS79 230
xref: PTHR18966:SF377
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot F6QXA9 473
xref: PTHR24356:SF318
organism: Macaca mulatta

uniprot F6WJB1 85
type: UnificationXref
id: F6WJB1
db: uniprot

uniprot Q5PU49 535
type: UnificationXref
id: Q5PU49
db: uniprot

uniprot P21836 177
type: UnificationXref
id: P21836
db: uniprot

uniprot Q8VHN2 264
type: UnificationXref
id: Q8VHN2
db: uniprot

uniprot A0A3Q2UC01 165
type: UnificationXref
id: A0A3Q2UC01
db: uniprot

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 14

uniprot A0A2I3RQJ8 450
type: UnificationXref
id: A0A2I3RQJ8
db: uniprot

uniprot F1NG47 470
type: UnificationXref
id: F1NG47
db: uniprot

ncbitaxon 5786 308
type: UnificationXref
id: 5786
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot P61954 391
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7E376 355
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot P61952 389
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 440
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot P61953 390
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r8 610
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

GO GO:0008021 2
type: UnificationXref
id: GO:0008021
db: GO

Protein kinase C zeta type
type: ProteinReference
xref: uniprot P09217 501
xref: PTHR24356:SF170
organism: Rattus norvegicus

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot P09216 500
organism: Rattus norvegicus

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot P09215 499
organism: Rattus norvegicus

uniprot E2R2S3 297
type: UnificationXref
id: E2R2S3
db: uniprot

uniprot W4Y9B6 163
type: UnificationXref
id: W4Y9B6
db: uniprot

uniprot M9PE71 98
type: UnificationXref
id: M9PE71
db: uniprot

uniprot Q5BJ11 415
type: UnificationXref
id: Q5BJ11
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q90Z40 441
organism: Danio rerio

uniprot F7F580 335
type: UnificationXref
id: F7F580
db: uniprot

uniprot P52287 385
type: UnificationXref
id: P52287
db: uniprot

Protein kinase C-like 1
type: ProteinReference
xref: PTHR24356:SF347
xref: uniprot P34722 511
organism: Caenorhabditis elegans

uniprot Q62442 145
type: UnificationXref
id: Q62442
db: uniprot

EGL-30
type: ProteinReference
xref: PTHR10218:SF329
xref: uniprot G5EGU1 345
organism: Caenorhabditis elegans

uniprot A1A4I4 456
type: UnificationXref
id: A1A4I4
db: uniprot

uniprot P54406 388
type: UnificationXref
id: P54406
db: uniprot

uniprot F1PGZ2 203
type: UnificationXref
id: F1PGZ2
db: uniprot

G-Protein
type: ProteinReference
xref: P01073
standard name: Gq-protein
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 1 and 3 signaling pathway.PROTEIN.GENERIC.G-Protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: G protein subunit beta 2
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Gnb2 protein
member entity reference: Guanine nucleotide-binding protein subunit beta-5
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
member entity reference: Guanine nucleotide binding protein, beta subunit
member entity reference: Uncharacterized protein
member entity reference: G protein subunit alpha 14
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
member entity reference: G protein subunit beta 5
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
member entity reference: AGAP005913-PA
member entity reference: Guanine nucleotide-binding protein (G protein), beta 5
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
member entity reference: Guanine nucleotide-binding protein subunit alpha-11
member entity reference: G protein subunit beta 4
member entity reference: G protein subunit gamma 5
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: Gnb1l protein
member entity reference: Guanine nucleotide-binding protein (G protein), q polypeptide
member entity reference: G protein subunit alpha q
member entity reference: G protein alpha q subunit
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
member entity reference: Gnb3 protein
member entity reference: Guanine nucleotide-binding protein subunit gamma-1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
member entity reference: Guanine nucleotide-binding protein beta subunit
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 14
member entity reference: Guanine nucleotide binding protein, beta 3

Acetylcholinesterase
type: ProteinReference
xref: uniprot P23795 179
organism: Bos taurus

uniprot A5PEW5 74
type: UnificationXref
id: A5PEW5
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: uniprot Q05513 527
xref: PTHR24356:SF170
organism: Homo sapiens

uniprot F6PGC8 315
type: UnificationXref
id: F6PGC8
db: uniprot

uniprot P20444 506
type: UnificationXref
id: P20444
db: uniprot

Protein kinase N3
type: ProteinReference
xref: uniprot A0A3Q1LM61 453
xref: PTHR24356:SF318
organism: Bos taurus

Protein kinase N1
type: ProteinReference
xref: uniprot A0A2I3REJ5 449
xref: PTHR24356:SF246
organism: Pan troglodytes

uniprot K7CBH8 492
type: UnificationXref
id: K7CBH8
db: uniprot

ncbitaxon 9606 24
type: UnificationXref
id: 9606
db: ncbitaxon

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 324
organism: Macaca mulatta

uniprot P26308 367
type: UnificationXref
id: P26308
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F7H3B3 484
xref: PTHR24356:SF162
organism: Macaca mulatta

uniprot Q9GZV3 277
type: UnificationXref
id: Q9GZV3
db: uniprot

uniprot F1PR75 15
type: UnificationXref
id: F1PR75
db: uniprot

uniprot P30677 372
type: UnificationXref
id: P30677
db: uniprot

CHT1 s11 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHT1
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase N2
type: ProteinReference
xref: PTHR24356:SF322
xref: uniprot Q16513 531
organism: Homo sapiens

uniprot P41743 515
type: UnificationXref
id: P41743
db: uniprot

uniprot A0A2I3TUD1 282
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

uniprot F7ERP8 333
type: UnificationXref
id: F7ERP8
db: uniprot

choline
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P08482 206
type: UnificationXref
id: P08482
db: uniprot

uniprot E1BW98 295
type: UnificationXref
id: E1BW98
db: uniprot

Serine/threonine-protein kinase N1
type: ProteinReference
xref: uniprot Q16512 530
xref: PTHR24356:SF246
organism: Homo sapiens

uniprot Q61016 423
type: UnificationXref
id: Q61016
db: uniprot

AGAP012252-PA (Fragment)
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot Q7Q042 540
organism: Anopheles gambiae

uniprot H2Q995 94
type: UnificationXref
id: H2Q995
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot H9EU39 491
organism: Macaca mulatta

t-SNARE protein aex-4
type: ProteinReference
xref: uniprot G5EEN8 93
organism: Caenorhabditis elegans

ncbitaxon 7227 22
type: UnificationXref
id: 7227
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r8 611
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

PKC
type: ProteinReference
xref: P01074
standard name: Protein kinase C
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 1 and 3 signaling pathway.PROTEIN.GENERIC.PKC
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Protein kinase C Synonym: PKC Accession: P01074
member entity reference: Serine/threonine-protein kinase N3
member entity reference: Protein kinase C-like 1
member entity reference: Protein kinase C-like
member entity reference: Serine/threonine-protein kinase N2
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C
member entity reference: Protein kinase C gamma type
member entity reference: Protein kinase C eta type
member entity reference: Protein kinase C-like 3
member entity reference: Protein kinase C zeta type
member entity reference: Protein kinase C delta type
member entity reference: Protein kinase C iota type
member entity reference: Serine/threonine-protein kinase N1
member entity reference: Protein kinase C theta type
member entity reference: Protein kinase C-like 1B
member entity reference: PKN2 isoform 2
member entity reference: Protein kinase N1
member entity reference: Protein kinase C beta type
member entity reference: Atypical protein kinase C
member entity reference: Protein kinase C-like 2
member entity reference: Protein kinase C, brain isozyme
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase N
member entity reference: Protein kinase N3
member entity reference: Protein kinase C alpha type
member entity reference: Putative protein kinase C delta type homolog

PARTICIPANT STOICHIOMETRY r8 612
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

uniprot P49177 379
type: UnificationXref
id: P49177
db: uniprot

uniprot F2Z3T8 312
type: UnificationXref
id: F2Z3T8
db: uniprot

DISSOCIATION_LEFT__PIP2-RIGHT__DAG-_IP3-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 610
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 611
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 612
left: PIP2
interaction type: DISSOCIATION
right: IP3
right: DAG

SNARE COMPLEX
type: ProteinReference
xref: P01066
standard name: N-ethylmaleimide-sensitive factor attachment protein receptor
comment: ENTITY_REFERENCE_NOTES= Long Name: N-ethylmaleimide-sensitive factor attachment protein receptor Synonym: SNARE Accession: P01066
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 1 and 3 signaling pathway.PROTEIN.GENERIC.SNARE COMPLEX
member entity reference: Syntaxin 1A
member entity reference: Vesicle associated membrane protein 8
member entity reference: Synaptosomal-associated protein
member entity reference: Synaptobrevin homolog 1
member entity reference: Uncharacterized protein
member entity reference: STX1A isoform 3
member entity reference: Synaptosomal-associated protein 29
member entity reference: Syntaxin-1A isoform 1
member entity reference: Synaptosomal-associated protein 23
member entity reference: Vesicle-associated membrane protein 8
member entity reference: Vesicle-associated membrane protein 2
member entity reference: Synaptosomal-associated protein 25
member entity reference: VAMP2 isoform 3
member entity reference: Vesicle-associated membrane protein 8 (Endobrevin)
member entity reference: Putative SNAP25 homologous protein SNAP30
member entity reference: Vesicle-associated membrane protein 1
member entity reference: Syntaxin-1A
member entity reference: Syntaxin-1B
member entity reference: LD03592p
member entity reference: SNAP29 isoform 1
member entity reference: Syntaxin 1B
member entity reference: Vesicle-associated membrane protein 3
member entity reference: SNAP25 homologous protein SNAP33
member entity reference: Putative synaptobrevin homologue SNC1/2 (Eurofung)
member entity reference: Synaptobrevin
member entity reference: Synaptosomal-associated protein 25-A
member entity reference: t-SNARE protein aex-4
member entity reference: Synaptobrevin-1
member entity reference: AGAP007698-PB
member entity reference: SNAP25 homologous protein SNAP29
member entity reference: Soluble NSF attachment protein 29

uniprot F6PVT7 316
type: UnificationXref
id: F6PVT7
db: uniprot

Protein kinase C alpha type
type: ProteinReference
xref: uniprot P17252 505
xref: PTHR24356:SF193
organism: Homo sapiens

uniprot P22303 178
type: UnificationXref
id: P22303
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot P23763 108
organism: Homo sapiens

uniprot H2Q1D9 347
type: UnificationXref
id: H2Q1D9
db: uniprot

uniprot Q00959 245
type: UnificationXref
id: Q00959
db: uniprot

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 275

uniprot H2QDQ1 489
type: UnificationXref
id: H2QDQ1
db: uniprot

G protein subunit beta 3
type: ProteinReference
xref: uniprot H2R3A6 352
organism: Pan troglodytes

uniprot Q5TZ66 144
type: UnificationXref
id: Q5TZ66
db: uniprot

uniprot Q9W3J1 446
type: UnificationXref
id: Q9W3J1
db: uniprot

CHAT isoform 7
type: ProteinReference
xref: uniprot H2RAF8 19
xref: PTHR22589:SF14
organism: Pan troglodytes

uniprot F7CXD0 329
type: UnificationXref
id: F7CXD0
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot A0A2R8QJ48 452
xref: PTHR24356:SF192
organism: Danio rerio

uniprot P50148 380
type: UnificationXref
id: P50148
db: uniprot

VAChT
type: Protein
entity reference: VAChT
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa8 560
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

Uncharacterized protein
type: ProteinReference
xref: PTHR24356:SF322
xref: uniprot F7C0E0 481
organism: Macaca mulatta

uniprot F6XWE8 321
type: UnificationXref
id: F6XWE8
db: uniprot

PTHR48086:SF7
type: RelationshipXref
id: PTHR48086:SF7
db: PANTHER Family
relationship type: By Homology

uniprot G5EGQ9 233
type: UnificationXref
id: G5EGQ9
db: uniprot

ncbitaxon 284812 151
type: UnificationXref
id: 284812
db: ncbitaxon

Candida albicans
type: BioSource
xref: ncbitaxon 237561 534

Glutamate receptor ionotropic, NMDA 1
type: ProteinReference
evidence: Evidence 234
xref: uniprot Q5R1P0 256
xref: PTHR18966:SF377
organism: Canis lupus familiaris

uniprot Q803H5 439
type: UnificationXref
id: Q803H5
db: uniprot

Glutamate receptor ionotropic, NMDA 2B
type: ProteinReference
evidence: Evidence 234
evidence: Evidence 242
xref: PTHR18966:SF382
xref: uniprot Q5R1P3 257
organism: Canis lupus familiaris

ncbitaxon 7739 168
type: UnificationXref
id: 7739
db: ncbitaxon

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot Q9JKC1 185
organism: Rattus norvegicus

uniprot Q00960 246
type: UnificationXref
id: Q00960
db: uniprot

G Protein s2 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

NMDA class glutamate Receptor
type: ProteinReference
evidence: Evidence 234
xref: uniprot G5EGQ9 233
xref: PTHR18966:SF377
organism: Caenorhabditis elegans

High affinity choline transporter 1
type: ProteinReference
xref: uniprot Q9JMD7 278
organism: Rattus norvegicus

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 5

uniprot G3N3K3 232
type: UnificationXref
id: G3N3K3
db: uniprot

NMDA receptor 2, isoform C
type: ProteinReference
xref: PTHR18966:SF391
xref: uniprot Q9W581 266
organism: Drosophila melanogaster

Muscarinic acetylcholine receptor
type: ProteinReference
xref: PTHR24248:SF153
xref: uniprot A0A2J8M701 199
organism: Pan troglodytes

uniprot A0A1D5QIS2 71
type: UnificationXref
id: A0A1D5QIS2
db: uniprot

PANTHER Pathway P00042 1
type: UnificationXref
id: P00042
db: PANTHER Pathway

ncbitaxon 13616 42
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot F7A818 47
type: UnificationXref
id: F7A818
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r76
controller: IP3

uniprot F7G7I9 340
type: UnificationXref
id: F7G7I9
db: uniprot

AChE
type: Protein
entity reference: AChE
comment: SPECIES_TYPE=PROTEIN

uniprot F7G3J2 339
type: UnificationXref
id: F7G3J2
db: uniprot

uniprot Q16623 132
type: UnificationXref
id: Q16623
db: uniprot

uniprot Q7SY24 542
type: UnificationXref
id: Q7SY24
db: uniprot

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q04759 526
organism: Homo sapiens

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot A0A3Q1MSP9 455
organism: Bos taurus

uniprot P18489 107
type: UnificationXref
id: P18489
db: uniprot

uniprot F1MCL3 223
type: UnificationXref
id: F1MCL3
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ERP8 333
organism: Ornithorhynchus anatinus

Serine/threonine-protein kinase N3
type: ProteinReference
xref: uniprot Q6P5Z2 539
xref: PTHR24356:SF318
organism: Homo sapiens

uniprot G5EBH0 191
type: UnificationXref
id: G5EBH0
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P36408 373
organism: Dictyostelium discoideum

Complex (CHT1/choline)
type: Complex
component stoichiometry: CHT1 s11 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: choline s12 sa11 STOICHIOMETRY ID COMPLEX
component: CHT1
component: choline
feature: COMPLEX BINDING FEATURE s93 a99 563
feature: COMPLEX BINDING FEATURE s93 a99 565
cellular location: axon terminus

uniprot Q8K045 546
type: UnificationXref
id: Q8K045
db: uniprot

AGAP001478-PA
type: ProteinReference
evidence: Evidence 234
xref: uniprot Q7PXM3 261
xref: PTHR18966:SF377
organism: Anopheles gambiae

uniprot F1MLQ5 10
type: UnificationXref
id: F1MLQ5
db: uniprot

uniprot Q9HAV0 443
type: UnificationXref
id: Q9HAV0
db: uniprot