TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r70
control type: ACTIVATION
controller: Ca2+ channel

Syntaxin-122
type: ProteinReference
xref: uniprot Q9SVC2 281
organism: Arabidopsis thaliana

AChE
type: ProteinReference
xref: P01080
standard name: acetylcholinesterase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: acetylcholinesterase Synonym: ACHE,AChE Accession: P01080
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 2 and 4 signaling pathway.PROTEIN.GENERIC.AChE
member entity reference: Carboxylic ester hydrolase
member entity reference: Acetylcholinesterase
member entity reference: Cholinesterase
member entity reference: Acetylcholinesterase 1

uniprot Q2KJD2 256
type: UnificationXref
id: Q2KJD2
db: uniprot

Neuronal synaptobrevin, isoform J
type: ProteinReference
xref: uniprot M9PE71 202
xref: PTHR45701:SF3
organism: Drosophila melanogaster

G protein subunit alpha i3
type: ProteinReference
xref: uniprot H2PZK9 444
organism: Pan troglodytes

uniprot P32756 134
type: UnificationXref
id: P32756
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q5ZJ03 529
organism: Gallus gallus

uniprot Q9ERZ4 147
type: UnificationXref
id: Q9ERZ4
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P07278 62
organism: Saccharomyces cerevisiae

Syntaxin-3
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot Q64704 263
organism: Mus musculus

G protein subunit alpha i1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F1P977 404
organism: Canis lupus familiaris

uniprot P38040 481
type: UnificationXref
id: P38040
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YFY5 421
xref: PTHR10218:SF67
organism: Monodelphis domestica

uniprot P50279 225
type: UnificationXref
id: P50279
db: uniprot

G protein subunit alpha transducin 2
type: ProteinReference
xref: PTHR10218:SF68
xref: uniprot H2PZL0 445
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IFL6 373
organism: Bos taurus

Guanine nucleotide-binding protein G(t) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF67
xref: uniprot P20612 475
organism: Mus musculus

Syntaxin 19
type: ProteinReference
xref: PTHR19957:SF29
xref: uniprot H2QMZ0 198
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RBE7 394
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r53 586
type: Stoichiometry
physical entity: Complex (GDP/G-Protein/ mAChR2/4)
stoichiometric coefficient: 1.0

uniprot O00161 203
type: UnificationXref
id: O00161
db: uniprot

PARTICIPANT STOICHIOMETRY r53 587
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

Giardia intestinalis
type: BioSource
xref: ncbitaxon 184922 19

uniprot Q61017 532
type: UnificationXref
id: Q61017
db: uniprot

uniprot Q7QBY8 360
type: UnificationXref
id: Q7QBY8
db: uniprot

STX11 isoform 1
type: ProteinReference
xref: PTHR19957:SF30
xref: uniprot H2QTV4 199
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r53 588
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 589
type: Stoichiometry
physical entity: Complex (GTP/G-Protein)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 590
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Mus musculus
type: BioSource
xref: ncbitaxon 10090 55

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XYX9 187
xref: PTHR45701:SF6
organism: Monodelphis domestica

PRKACB isoform 3
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot H2R1G3 44
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r53 591
type: Stoichiometry
physical entity: Complex (mAChR2/4/ ACh)
stoichiometric coefficient: 1.0

uniprot P23795 308
type: UnificationXref
id: P23795
db: uniprot

uniprot P54313 493
type: UnificationXref
id: P54313
db: uniprot

Syntaxin 1A
type: ProteinReference
xref: uniprot E2RTW9 174
organism: Giardia intestinalis

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 503
organism: Homo sapiens

PTHR19305:SF14
type: RelationshipXref
id: PTHR19305:SF14
db: PANTHER Family
relationship type: By Homology

uniprot E2RTP0 18
type: UnificationXref
id: E2RTP0
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P17612 75
organism: Homo sapiens

uniprot Q9JMD7 366
type: UnificationXref
id: Q9JMD7
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 502
organism: Mus musculus

uniprot Q8MJ44 117
type: UnificationXref
id: Q8MJ44
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 500
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 501
organism: Homo sapiens

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot P62881 505
organism: Mus musculus

PTHR10218:SF310
type: RelationshipXref
id: PTHR10218:SF310
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 504
organism: Mus musculus

Protein kinase cAMP-activated catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot F6T0T9 32
organism: Xenopus tropicalis

uniprot P40376 88
type: UnificationXref
id: P40376
db: uniprot

uniprot P11488 467
type: UnificationXref
id: P11488
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot F6UFJ7 181
organism: Macaca mulatta

uniprot Q9USH7 284
type: UnificationXref
id: Q9USH7
db: uniprot

uniprot Q9WUF4 288
type: UnificationXref
id: Q9WUF4
db: uniprot

uniprot Q08850 244
type: UnificationXref
id: Q08850
db: uniprot

uniprot Q7Q6D4 545
type: UnificationXref
id: Q7Q6D4
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 94

PTHR16305:SF28
type: RelationshipXref
id: PTHR16305:SF28
db: PANTHER Family
relationship type: By Homology

uniprot H2R3A6 452
type: UnificationXref
id: H2R3A6
db: uniprot

PRKAR1A isoform 12
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot H2R3M7 45
organism: Pan troglodytes

Gnai3 protein
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot A9JTC8 379
organism: Danio rerio

CAT
type: ProteinReference
xref: P01076
standard name: choline acetyltransferase
comment: ENTITY_REFERENCE_NOTES= Long Name: choline acetyltransferase Synonym: CAT,CHAT Accession: P01076
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 2 and 4 signaling pathway.PROTEIN.GENERIC.CAT
member entity reference: CHAT isoform 7
member entity reference: Uncharacterized protein
member entity reference: Choline O-acetyltransferase
member entity reference: Protein CBR-CHA-1
member entity reference: Carnitine Palmitoyl Transferase

uniprot F6WJB1 186
type: UnificationXref
id: F6WJB1
db: uniprot

uniprot Q03311 311
type: UnificationXref
id: Q03311
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2
type: ProteinReference
xref: uniprot F6WNJ9 417
xref: PTHR10218:SF73
organism: Xenopus tropicalis

Potassium channel, inwardly rectifying subfamily J, member 3
type: ProteinReference
xref: uniprot F6R882 329
xref: PTHR11767:SF16
organism: Xenopus tropicalis

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 499
organism: Bos taurus

uniprot A0A2I3SR99 162
type: UnificationXref
id: A0A2I3SR99
db: uniprot

Ca2+ channel
type: Protein
feature: ACTIVE 123
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=PROTEIN

uniprot P29829 478
type: UnificationXref
id: P29829
db: uniprot

uniprot Q8CXT1 115
type: UnificationXref
id: Q8CXT1
db: uniprot

Protein serine/threonine kinase, putative
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot Q5KP84 103
organism: Cryptococcus neoformans

uniprot F7D9M6 316
type: UnificationXref
id: F7D9M6
db: uniprot

High-affinity choline transporter 1
type: ProteinReference
xref: uniprot O02228 355
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot F7CTP1 427
organism: Macaca mulatta

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__GIRK-RIGHT__GIRK-_r71
controller: Complex (GTP/G-Protein)

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60879 228
organism: Mus musculus

Choline O-acetyltransferase
type: ProteinReference
xref: uniprot F1PR75 127
xref: PTHR22589:SF14
organism: Canis lupus familiaris

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60878 227
organism: Gallus gallus

Potassium voltage-gated channel subfamily J member 6
type: ProteinReference
xref: uniprot F1MUD1 327
xref: PTHR11767:SF19
organism: Bos taurus

uniprot F1PR75 127
type: UnificationXref
id: F1PR75
db: uniprot

uniprot O44619 131
type: UnificationXref
id: O44619
db: uniprot

TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_r73
type: TransportWithBiochemicalReaction
conversion direction: REVERSIBLE
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 606
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 607
left: K+
interaction type: TRANSPORT
right: K+

ncbitaxon 185431 98
type: UnificationXref
id: 185431
db: ncbitaxon

uniprot P61953 497
type: UnificationXref
id: P61953
db: uniprot

Putative synaptobrevin homologue SNC1/2 (Eurofung)
type: ProteinReference
xref: uniprot Q5ASG1 258
organism: Emericella nidulans

Guanine nucleotide binding protein, beta 3
type: ProteinReference
xref: uniprot Q5XGD8 528
organism: Xenopus tropicalis

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60877 226
organism: Macaca mulatta

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: uniprot F7ERG6 336
xref: PTHR11767:SF16
organism: Macaca mulatta

uniprot P63251 346
type: UnificationXref
id: P63251
db: uniprot

uniprot Q8MM62 119
type: UnificationXref
id: Q8MM62
db: uniprot

uniprot O65359 212
type: UnificationXref
id: O65359
db: uniprot

uniprot F7EPF6 335
type: UnificationXref
id: F7EPF6
db: uniprot

Syntaxin 16
type: ProteinReference
xref: uniprot E2RU39 175
organism: Giardia intestinalis

Protein CBR-SYX-2
type: ProteinReference
xref: uniprot A8X4Z4 166
organism: Caenorhabditis briggsae

uniprot A8X694 124
type: UnificationXref
id: A8X694
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 42

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60880 229
organism: Homo sapiens

uniprot P63045 238
type: UnificationXref
id: P63045
db: uniprot

Guanine nucleotide-binding protein G(O) subunit alpha 1
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot E9H7Z0 399
organism: Daphnia pulex

GIRK
type: Protein
entity reference: GIRK
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=PROTEIN

uniprot P68181 90
type: UnificationXref
id: P68181
db: uniprot

uniprot G5EB66 39
type: UnificationXref
id: G5EB66
db: uniprot

uniprot Q9ERB0 275
type: UnificationXref
id: Q9ERB0
db: uniprot

Ca2+ channel
type: Protein
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=PROTEIN

Protein CBR-CHO-1
type: ProteinReference
xref: uniprot A8WQR8 351
organism: Caenorhabditis briggsae

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q2KJD2 256
organism: Bos taurus

uniprot Q62442 261
type: UnificationXref
id: Q62442
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P68182 91
xref: PTHR24353:SF116
organism: Rattus norvegicus

uniprot D3ZLD6 385
type: UnificationXref
id: D3ZLD6
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P68181 90
xref: PTHR24353:SF116
organism: Mus musculus

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63044 237
organism: Mus musculus

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63045 238
organism: Rattus norvegicus

uniprot A4IFL6 373
type: UnificationXref
id: A4IFL6
db: uniprot

uniprot Q5KP84 103
type: UnificationXref
id: Q5KP84
db: uniprot

uniprot Q3ZB92 100
type: UnificationXref
id: Q3ZB92
db: uniprot

ncbitaxon 284812 87
type: UnificationXref
id: 284812
db: ncbitaxon

Synaptobrevin-1
type: ProteinReference
xref: PTHR45701:SF3
xref: uniprot O02495 204
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot Q5E9F0 526
organism: Bos taurus

uniprot F1MUD1 327
type: UnificationXref
id: F1MUD1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZSF0 384
organism: Branchiostoma floridae

Syntaxin 1A
type: ProteinReference
xref: PTHR19957:SF84
xref: uniprot Q0VFR6 246
organism: Xenopus tropicalis

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
type: ProteinReference
xref: uniprot Q6TNT8 541
xref: PTHR10218:SF73
organism: Danio rerio

axon terminus
type: CellularLocationVocabulary
xref: GO GO:0043679 3

uniprot F6WM87 34
type: UnificationXref
id: F6WM87
db: uniprot

uniprot F8W3G9 441
type: UnificationXref
id: F8W3G9
db: uniprot

Syntaxin-11
type: ProteinReference
xref: PTHR19957:SF30
xref: uniprot F6R0Q4 178
organism: Macaca mulatta

ncbitaxon 6238 13
type: UnificationXref
id: 6238
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r73 606
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

uniprot Q03059 135
type: UnificationXref
id: Q03059
db: uniprot

ncbitaxon 214684 104
type: UnificationXref
id: 214684
db: ncbitaxon

Vesicle-associated membrane protein 8 (Endobrevin)
type: ProteinReference
xref: uniprot Q7ZUC1 267
xref: PTHR45701:SF7
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r81 593
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r73 607
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r81 592
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

Muscarinic acetylcholine receptor M4
type: ProteinReference
xref: PTHR24247:SF180
xref: uniprot P08173 140
organism: Homo sapiens

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot A0A3Q2UC01 295
organism: Gallus gallus

uniprot P61266 232
type: UnificationXref
id: P61266
db: uniprot

uniprot F6PGC8 408
type: UnificationXref
id: F6PGC8
db: uniprot

uniprot P31109 220
type: UnificationXref
id: P31109
db: uniprot

Muscarinic acetylcholine receptor M2
type: ProteinReference
xref: uniprot P08172 139
xref: PTHR24247:SF207
organism: Homo sapiens

CHT1
type: Protein
entity reference: CHT1
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Protein kinase A catalytic subunit
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q27687 96
organism: Leishmania major

uniprot E9GNI4 23
type: UnificationXref
id: E9GNI4
db: uniprot

uniprot Q0VFC4 516
type: UnificationXref
id: Q0VFC4
db: uniprot

Kinase, AGC PKA
type: ProteinReference
xref: uniprot E2RTP0 18
organism: Giardia intestinalis

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63027 236
xref: PTHR45701:SF5
organism: Homo sapiens

uniprot Q8VZU2 271
type: UnificationXref
id: Q8VZU2
db: uniprot

Muscarinic acetylcholine receptor M2 (Fragment)
type: ProteinReference
xref: uniprot Q9N2A7 148
xref: PTHR24247:SF207
organism: Pan troglodytes

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63026 235
organism: Bos taurus

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot G5EDV9 303
organism: Caenorhabditis elegans

PTHR24247:SF207
type: RelationshipXref
id: PTHR24247:SF207
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r77 603
type: Stoichiometry
physical entity: VAChT
stoichiometric coefficient: 1.0

uniprot O60262 457
type: UnificationXref
id: O60262
db: uniprot

PARTICIPANT STOICHIOMETRY r77 604
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

uniprot A0A3Q2UC01 295
type: UnificationXref
id: A0A3Q2UC01
db: uniprot

uniprot Q7UFM6 361
type: UnificationXref
id: Q7UFM6
db: uniprot

Muscarinic acetylcholine receptor M2
type: ProteinReference
xref: uniprot P41985 146
xref: PTHR24247:SF207
organism: Bos taurus

Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot F1QEC8 25
organism: Danio rerio

Syntaxin-16
type: ProteinReference
xref: uniprot Q8BVI5 268
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r77 605
type: Stoichiometry
physical entity: Complex (VAChT/ACh)
stoichiometric coefficient: 1.0

uniprot P08485 141
type: UnificationXref
id: P08485
db: uniprot

uniprot H2Q0J3 317
type: UnificationXref
id: H2Q0J3
db: uniprot

Muscarinic acetylcholine receptor
type: ProteinReference
xref: uniprot F7DJJ2 138
xref: PTHR24247:SF207
organism: Monodelphis domestica

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63024 233
organism: Mus musculus

Vesicle-associated membrane protein 3
type: ProteinReference
xref: uniprot P63025 234
xref: PTHR45701:SF6
organism: Rattus norvegicus

uniprot P00515 51
type: UnificationXref
id: P00515
db: uniprot

uniprot F6Z5I2 189
type: UnificationXref
id: F6Z5I2
db: uniprot

uniprot Q7ZW82 549
type: UnificationXref
id: Q7ZW82
db: uniprot

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 408
organism: Ornithorhynchus anatinus

uniprot F1QEC8 25
type: UnificationXref
id: F1QEC8
db: uniprot

uniprot P07278 62
type: UnificationXref
id: P07278
db: uniprot

DISSOCIATION_LEFT__ACh-RIGHT__Acetyl_CoA-_choline-_r59
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 622
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 621
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 620
left: ACh
interaction type: DISSOCIATION
right: choline
right: Acetyl CoA

Syntaxin-like protein 1
type: ProteinReference
xref: uniprot E2RTQ4 173
organism: Giardia intestinalis

Muscarinic acetylcholine receptor 2 and 4 signaling pathway
type: Pathway
pathway component: DISSOCIATION_LEFT__Complex__CHT1_choline_-RIGHT__choline-_CHT1-_r80
pathway component: STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_r69
pathway component: DISSOCIATION_LEFT__Complex__GDP_G_Protein__mAChR2_4_-_ACh-_GTP-RIGHT__Complex__GTP_G_Protein_-_GDP-_Complex__mAChR2_4__ACh_-_r53
pathway component: DISSOCIATION_LEFT__ACh-RIGHT__Acetyl_CoA-_choline-_r59
pathway component: TRANSPORT_LEFT__ACh-RIGHT__ACh-_r81
pathway component: STATE_TRANSITION_LEFT__GIRK-RIGHT__GIRK-_r71
pathway component: HETERODIMER_ASSOCIATION_LEFT__VAChT-_ACh-RIGHT__Complex__VAChT_ACh_-_r77
pathway component: HETERODIMER_ASSOCIATION_LEFT__Acetyl_CoA-_choline-RIGHT__ACh-_r56
pathway component: TRANSPORT_LEFT__Acetyl_CoA-RIGHT__Acetyl_CoA-_r82
pathway component: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_r44
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_r67
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r70
pathway component: TRIGGER
pathway component: DISSOCIATION_LEFT__Complex__VAChT_ACh_-RIGHT__ACh-_VAChT-_r78
pathway component: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_r73
pathway component: HETERODIMER_ASSOCIATION_LEFT__CHT1-_choline-RIGHT__Complex__CHT1_choline_-_r79
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r68
xref: PANTHER Pathway P00043 1
comment: MODEL_NOTES=Panther Pathway: P00043 Muscarinic Acetylcholine Receptor 2, 4 Pathway: Muscarinic ACh receptors are negatively coupled to PKA and intracellular cAMP signaling. These receptors are found in the brain controlling attention (eg. reduction of cholinergic fibers in elderly and trisomy 21 patients leads to Alzheimer's disease) and peripheral nervous system controlling parasympathetic responses (eg. release of acetylcholine from the vagus nerve reduces heart rate and blood pressure). These receptors are important existing drug targets for heart disease, hypertension, bronchial asthma, anesthesia, Alzheimer's disease, and one of the main mechanisms for dilated cardiomyopathy is likely to be autoimmune (against m2) mediated myocardial damage. Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12667888 Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9711178 Website=http://www.ptd.neu.edu/neuroanatomy/cyberclass/pharmacology/acetylcholine.htm Website=http://www.unifr.ch/biochem/DREYER/Neurotransmitters/acetylcholine.htm PMID: 12667888 PMID: 9711178

Syntaxin-1A
type: ProteinReference
xref: PTHR19957:SF84
xref: uniprot Q16623 249
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R9G5 393
organism: Canis lupus familiaris

uniprot P63077 506
type: UnificationXref
id: P63077
db: uniprot

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot O70404 213
organism: Mus musculus

ncbitaxon 9615 16
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot E2RPY4 326
type: UnificationXref
id: E2RPY4
db: uniprot

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot O14775 456
organism: Homo sapiens

GIRK
type: Protein
entity reference: GIRK
feature: ACTIVE 123
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=PROTEIN

VAMP2 isoform 3
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot H2RCB8 201
organism: Pan troglodytes

uniprot Q9ZQZ8 290
type: UnificationXref
id: Q9ZQZ8
db: uniprot

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot F6Z5I2 189
xref: PTHR45701:SF7
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RIM7 410
organism: Monodelphis domestica

uniprot Q5BK52 101
type: UnificationXref
id: Q5BK52
db: uniprot

Portabella
type: ProteinReference
xref: PTHR23506:SF4
xref: uniprot Q9VCJ5 156
organism: Drosophila melanogaster

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot P21137 76
organism: Caenorhabditis elegans

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 391
organism: Canis lupus familiaris

ncbitaxon 3702 211
type: UnificationXref
id: 3702
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_r69
controller: PKA

uniprot E2RR72 172
type: UnificationXref
id: E2RR72
db: uniprot

uniprot E1BW98 388
type: UnificationXref
id: E1BW98
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R2S3 390
organism: Canis lupus familiaris

uniprot Q6TNT8 541
type: UnificationXref
id: Q6TNT8
db: uniprot

uniprot P17200 143
type: UnificationXref
id: P17200
db: uniprot

Syntaxin-2
type: ProteinReference
xref: PTHR19957:SF36
xref: uniprot Q00262 242
organism: Mus musculus

uniprot Q9VE46 367
type: UnificationXref
id: Q9VE46
db: uniprot

MODULATION
type: RelationshipTypeVocabulary

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 27

G Protein s5 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

uniprot P63026 235
type: UnificationXref
id: P63026
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F8W3G9 441
organism: Danio rerio

uniprot Q9GZV3 365
type: UnificationXref
id: Q9GZV3
db: uniprot

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
type: ProteinReference
xref: uniprot Q6DBV8 106
xref: PTHR24353:SF135
organism: Danio rerio

Protein kinase, cAMP-dependent, catalytic, beta a
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot Q7T374 114
organism: Danio rerio

ncbitaxon 5664 21
type: UnificationXref
id: 5664
db: ncbitaxon

uniprot P63219 515
type: UnificationXref
id: P63219
db: uniprot

uniprot X1WDQ5 561
type: UnificationXref
id: X1WDQ5
db: uniprot

G protein subunit alpha transducin 2
type: ProteinReference
xref: PTHR10218:SF68
xref: uniprot D4AA42 387
organism: Rattus norvegicus

uniprot P05132 54
type: UnificationXref
id: P05132
db: uniprot

uniprot O75558 214
type: UnificationXref
id: O75558
db: uniprot

AGAP002366-PA
type: ProteinReference
xref: uniprot Q7QBY8 360
organism: Anopheles gambiae

Potassium voltage-gated channel subfamily J member 3
type: ProteinReference
xref: PTHR11767:SF16
xref: uniprot F6WTY3 333
organism: Ornithorhynchus anatinus

G protein subunit alpha i2
type: ProteinReference
xref: uniprot H2QMN4 449
xref: PTHR10218:SF73
organism: Pan troglodytes

ACh
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P61952 496
type: UnificationXref
id: P61952
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot O95721 215
organism: Homo sapiens

uniprot P48051 338
type: UnificationXref
id: P48051
db: uniprot

Protein kinase cAMP-dependent type II regulatory subunit alpha
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot E2RRD1 17
organism: Canis lupus familiaris

uniprot E2RTW9 174
type: UnificationXref
id: E2RTW9
db: uniprot

uniprot F6TFY2 411
type: UnificationXref
id: F6TFY2
db: uniprot

uniprot Q7Q3T7 113
type: UnificationXref
id: Q7Q3T7
db: uniprot

Muscarinic acetylcholine receptor M2
type: ProteinReference
xref: PTHR24247:SF207
xref: uniprot P10980 142
organism: Rattus norvegicus

Protein kinase cAMP-dependent type I regulatory subunit alpha
type: ProteinReference
xref: uniprot F6R7N8 30
xref: PTHR11635:SF129
organism: Monodelphis domestica

uniprot Q08C49 95
type: UnificationXref
id: Q08C49
db: uniprot

Muscarinic acetylcholine receptor M2
type: ProteinReference
xref: uniprot P30372 144
xref: PTHR24247:SF207
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot W4Y9B6 293
organism: Strongylocentrotus purpuratus

DISSOCIATION
type: RelationshipTypeVocabulary

uniprot E2RJB3 397
type: UnificationXref
id: E2RJB3
db: uniprot

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot Q9DC51 556
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot A8XW88 14
xref: PTHR24353:SF117
organism: Caenorhabditis briggsae

Adenylate cyclase type 10
type: ProteinReference
xref: PTHR16305:SF28
xref: uniprot H2Q0J3 317
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50150 487
organism: Homo sapiens

uniprot H2Q1W2 150
type: UnificationXref
id: H2Q1W2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot P50151 488
organism: Homo sapiens

uniprot Q6PBY0 538
type: UnificationXref
id: Q6PBY0
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot P50154 490
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot A0A3Q1LYB4 163
organism: Bos taurus

uniprot P17612 75
type: UnificationXref
id: P17612
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_r44
control type: INHIBITION
controller: Complex (GTP/G-Protein)

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50153 489
organism: Mus musculus

uniprot P17343 470
type: UnificationXref
id: P17343
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P50146 485
organism: Gallus gallus

Guanine nucleotide-binding protein G(t) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF68
xref: uniprot P50149 486
organism: Mus musculus

PTHR24248:SF142
type: RelationshipXref
id: PTHR24248:SF142
db: PANTHER Family
relationship type: By Homology

uniprot P28329 132
type: UnificationXref
id: P28329
db: uniprot

Putative syntaxin-2
type: ProteinReference
xref: uniprot Q20574 253
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot F6SED9 179
organism: Monodelphis domestica

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot Q01386 93
organism: Neurospora crassa

uniprot P00517 52
type: UnificationXref
id: P00517
db: uniprot

AGAP002369-PA
type: ProteinReference
xref: uniprot Q7PR83 155
xref: PTHR23506:SF13
organism: Anopheles gambiae

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: uniprot P12849 71
xref: PTHR11635:SF126
organism: Mus musculus

Muscarinic acetylcholine receptor M2
type: ProteinReference
xref: uniprot Q9ERZ4 147
xref: PTHR24247:SF207
organism: Mus musculus

G protein alpha subunit Gi isoform X2
type: ProteinReference
xref: PTHR10218:SF310
xref: uniprot Q8WSS1 552
organism: Ciona intestinalis

uniprot P41985 146
type: UnificationXref
id: P41985
db: uniprot

uniprot P05987 58
type: UnificationXref
id: P05987
db: uniprot

PARTICIPANT STOICHIOMETRY r67 619
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

uniprot P08173 140
type: UnificationXref
id: P08173
db: uniprot

PARTICIPANT STOICHIOMETRY r67 618
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P27791 80
organism: Rattus norvegicus

uniprot P31323 83
type: UnificationXref
id: P31323
db: uniprot

uniprot P60880 229
type: UnificationXref
id: P60880
db: uniprot

uniprot Q15KE4 518
type: UnificationXref
id: Q15KE4
db: uniprot

uniprot D4AA42 387
type: UnificationXref
id: D4AA42
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YMH2 188
xref: PTHR45701:SF6
organism: Macaca mulatta

uniprot Q922R0 120
type: UnificationXref
id: Q922R0
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

Syntaxin-like protein psy1
type: ProteinReference
xref: uniprot Q9USH7 284
organism: Schizosaccharomyces pombe

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DNS6 191
xref: PTHR19957:SF334
organism: Macaca mulatta

PTHR10218:SF302
type: RelationshipXref
id: PTHR10218:SF302
db: PANTHER Family
relationship type: By Homology

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q9BV40 273
organism: Homo sapiens

uniprot Q7PZC6 112
type: UnificationXref
id: Q7PZC6
db: uniprot

uniprot K7AEL3 49
type: UnificationXref
id: K7AEL3
db: uniprot

KCNJ3 isoform 1
type: ProteinReference
xref: PTHR11767:SF16
xref: uniprot H2QIU3 337
organism: Pan troglodytes

uniprot Q5BJ11 525
type: UnificationXref
id: Q5BJ11
db: uniprot

uniprot F7E427 429
type: UnificationXref
id: F7E427
db: uniprot

uniprot Q92806 349
type: UnificationXref
id: Q92806
db: uniprot

Syntaxin, Qa-SNARE family
type: ProteinReference
xref: uniprot O96189 216
organism: Plasmodium falciparum

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot F6WM87 34
xref: PTHR11635:SF129
organism: Macaca mulatta

Acetyl CoA
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P32851 221
type: UnificationXref
id: P32851
db: uniprot

Vesicular acetylcholine transporter
type: ProteinReference
xref: uniprot O17444 151
organism: Drosophila melanogaster

uniprot H2Q1D9 446
type: UnificationXref
id: H2Q1D9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A943 190
xref: PTHR45701:SF5
organism: Monodelphis domestica

Soluble NSF attachment protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot P83351 240
organism: Caenorhabditis elegans

High affinity choline transporter 1
type: ProteinReference
xref: uniprot Q9GZV3 365
organism: Homo sapiens

uniprot F6R882 329
type: UnificationXref
id: F6R882
db: uniprot

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: PTHR11767:SF16
xref: uniprot P63250 345
organism: Mus musculus

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: PTHR11767:SF16
xref: uniprot P63251 346
organism: Rattus norvegicus

Prkar1a protein
type: ProteinReference
xref: uniprot Q5I0F6 102
xref: PTHR11635:SF129
organism: Danio rerio

Syntaxin-124
type: ProteinReference
xref: uniprot O64791 210
organism: Arabidopsis thaliana

Uncharacterized protein
type: ProteinReference
xref: uniprot F6QHN1 354
organism: Macaca mulatta

uniprot Q20574 253
type: UnificationXref
id: Q20574
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot H2Q9G5 448
organism: Pan troglodytes

ncbitaxon 227321 40
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot Q64704 263
type: UnificationXref
id: Q64704
db: uniprot

uniprot Q9Z286 322
type: UnificationXref
id: Q9Z286
db: uniprot

uniprot P21836 306
type: UnificationXref
id: P21836
db: uniprot

uniprot D3ZUH2 168
type: UnificationXref
id: D3ZUH2
db: uniprot

mAChR2/4
type: Protein
entity reference: mAChR2/4
feature: mAChR2 4 s6 sa3 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa3 567
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=PROTEIN

uniprot Q6DGZ5 533
type: UnificationXref
id: Q6DGZ5
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63219 515
organism: Rattus norvegicus

GDP s3 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 514
organism: Homo sapiens

uniprot P50150 487
type: UnificationXref
id: P50150
db: uniprot

mAChR2 4 s6 sa3 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.4633432079864352
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot F6Q503 26
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63217 513
organism: Bos taurus

uniprot P63215 511
type: UnificationXref
id: P63215
db: uniprot

Putative syntaxin-131
type: ProteinReference
xref: uniprot Q9SRV7 280
organism: Arabidopsis thaliana

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63216 512
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 511
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63214 510
organism: Bos taurus

PTHR43918:SF4
type: RelationshipXref
id: PTHR43918:SF4
db: PANTHER Family
relationship type: By Homology

PTHR43918:SF5
type: RelationshipXref
id: PTHR43918:SF5
db: PANTHER Family
relationship type: By Homology

uniprot Q5I080 527
type: UnificationXref
id: Q5I080
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 13

uniprot H2RER5 46
type: UnificationXref
id: H2RER5
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q15KE4 518
organism: Danio rerio

uniprot P32867 222
type: UnificationXref
id: P32867
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 77

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot P29829 478
organism: Drosophila melanogaster

uniprot Q6NW93 107
type: UnificationXref
id: Q6NW93
db: uniprot

uniprot P32211 145
type: UnificationXref
id: P32211
db: uniprot

uniprot P63250 345
type: UnificationXref
id: P63250
db: uniprot

Syntaxin 1B
type: ProteinReference
xref: uniprot F7EP58 192
xref: PTHR19957:SF334
organism: Xenopus tropicalis

G protein subunit alpha i1
type: ProteinReference
xref: uniprot A0A2I3S4R3 368
xref: PTHR10218:SF227
organism: Pan troglodytes

Protein SSO2
type: ProteinReference
xref: uniprot P39926 224
organism: Saccharomyces cerevisiae

Ca2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

Ca2+
type: SmallMolecule
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=ION

uniprot P38400 482
type: UnificationXref
id: P38400
db: uniprot

High-affinity choline transporter 1
type: ProteinReference
xref: uniprot Q9VE46 367
organism: Drosophila melanogaster

uniprot E2R2S8 391
type: UnificationXref
id: E2R2S8
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7F580 433
organism: Macaca mulatta

uniprot Q17499 136
type: UnificationXref
id: Q17499
db: uniprot

uniprot F6R0Q4 178
type: UnificationXref
id: F6R0Q4
db: uniprot

PTHR19957:SF334
type: RelationshipXref
id: PTHR19957:SF334
db: PANTHER Family
relationship type: By Homology

G protein subunit alpha o1
type: ProteinReference
xref: uniprot A0A2I3TFM8 369
xref: PTHR10218:SF302
organism: Pan troglodytes

uniprot A0A3Q1MHN1 323
type: UnificationXref
id: A0A3Q1MHN1
db: uniprot

uniprot F6RLG5 128
type: UnificationXref
id: F6RLG5
db: uniprot

uniprot P81900 92
type: UnificationXref
id: P81900
db: uniprot

uniprot C3ZRW7 299
type: UnificationXref
id: C3ZRW7
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot Q9CXP8 555
organism: Mus musculus

uniprot F7GI54 438
type: UnificationXref
id: F7GI54
db: uniprot

PTHR43918:SF3
type: RelationshipXref
id: PTHR43918:SF3
db: PANTHER Family
relationship type: By Homology

uniprot P51817 89
type: UnificationXref
id: P51817
db: uniprot

uniprot H2R3M7 45
type: UnificationXref
id: H2R3M7
db: uniprot

Adenylate cyclase type 10
type: ProteinReference
xref: uniprot Q9Z286 322
xref: PTHR16305:SF28
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P04897 460
xref: PTHR10218:SF73
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P59215 495
organism: Rattus norvegicus

uniprot P11017 466
type: UnificationXref
id: P11017
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RGI5 395
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P04899 461
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RLG5 128
xref: PTHR22589:SF14
organism: Macaca mulatta

uniprot F7ERP8 431
type: UnificationXref
id: F7ERP8
db: uniprot

ncbitaxon 7739 298
type: UnificationXref
id: 7739
db: ncbitaxon

eco ECO:0000305 22
type: UnificationXref
id: ECO:0000305
db: eco

G protein alpha o subunit
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P16378 468
organism: Drosophila melanogaster

Synaptobrevin
type: ProteinReference
xref: PTHR45701:SF10
xref: uniprot P18489 218
organism: Drosophila melanogaster

uniprot H2QIU3 337
type: UnificationXref
id: H2QIU3
db: uniprot

cAMP
type: SmallMolecule
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Protein SSO1
type: ProteinReference
xref: uniprot P32867 222
organism: Saccharomyces cerevisiae

Acetylcholinesterase
type: ProteinReference
xref: uniprot Q9DDE3 313
xref: PTHR43918:SF3
organism: Danio rerio

TRANSPORT
type: RelationshipTypeVocabulary

SNAP25 homologous protein SNAP29
type: ProteinReference
xref: uniprot Q9SD96 279
organism: Arabidopsis thaliana

uniprot F7FD32 434
type: UnificationXref
id: F7FD32
db: uniprot

Syntaxin-11
type: ProteinReference
xref: uniprot O75558 214
xref: PTHR19957:SF30
organism: Homo sapiens

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 377

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 104

uniprot O74852 152
type: UnificationXref
id: O74852
db: uniprot

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P17343 470
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P18872 472
organism: Mus musculus

ncbitaxon 5786 401
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot F7EBE7 430
type: UnificationXref
id: F7EBE7
db: uniprot

PTHR24353:SF133
type: RelationshipXref
id: PTHR24353:SF133
db: PANTHER Family
relationship type: By Homology

uniprot P18489 218
type: UnificationXref
id: P18489
db: uniprot

uniprot P63216 512
type: UnificationXref
id: P63216
db: uniprot

uniprot P54406 494
type: UnificationXref
id: P54406
db: uniprot

uniprot P10980 142
type: UnificationXref
id: P10980
db: uniprot

PTHR24353:SF137
type: RelationshipXref
id: PTHR24353:SF137
db: PANTHER Family
relationship type: By Homology

PTHR24247:SF180
type: RelationshipXref
id: PTHR24247:SF180
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF135
type: RelationshipXref
id: PTHR24353:SF135
db: PANTHER Family
relationship type: By Homology

uniprot P22303 307
type: UnificationXref
id: P22303
db: uniprot

uniprot O02495 204
type: UnificationXref
id: O02495
db: uniprot

uniprot Q9ZSD4 291
type: UnificationXref
id: Q9ZSD4
db: uniprot

uniprot E2RP98 300
type: UnificationXref
id: E2RP98
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3SZ98 523
organism: Bos taurus

Synaptosomal-associated protein 25-A
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q5TZ66 260
organism: Danio rerio

G protein-activated inward rectifier potassium channel 2
type: ProteinReference
xref: PTHR11767:SF19
xref: uniprot F7DHW8 334
organism: Macaca mulatta

Choline O-acetyltransferase
type: ProteinReference
xref: PTHR22589:SF14
xref: uniprot F1MLQ5 125
organism: Bos taurus

Syntaxin-41
type: ProteinReference
xref: uniprot O65359 212
organism: Arabidopsis thaliana

uniprot Q28HP6 255
type: UnificationXref
id: Q28HP6
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot A5PEW5 165
organism: Caenorhabditis elegans

uniprot H2R1G3 44
type: UnificationXref
id: H2R1G3
db: uniprot

uniprot F7G4Q0 36
type: UnificationXref
id: F7G4Q0
db: uniprot

Carnitine Palmitoyl Transferase
type: ProteinReference
xref: uniprot O44619 131
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r69 613
type: Stoichiometry
physical entity: Ca2+ channel
stoichiometric coefficient: 1.0

uniprot P52287 491
type: UnificationXref
id: P52287
db: uniprot

PARTICIPANT STOICHIOMETRY r69 612
type: Stoichiometry
physical entity: Ca2+ channel
stoichiometric coefficient: 1.0

Syntaxin 4
type: ProteinReference
xref: uniprot A0A452DIB2 164
organism: Bos taurus

uniprot E2QUL2 170
type: UnificationXref
id: E2QUL2
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 298

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q1D9 446
organism: Pan troglodytes

uniprot Q9U295 315
type: UnificationXref
id: Q9U295
db: uniprot

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot F7HPD8 301
xref: PTHR43918:SF3
organism: Macaca mulatta

uniprot F6VM87 183
type: UnificationXref
id: F6VM87
db: uniprot

GNAI2 protein
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot A7MBH9 378
organism: Bos taurus

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

Syntaxin 4
type: ProteinReference
xref: uniprot F6V9G5 182
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P52287 491
organism: Rattus norvegicus

uniprot P50151 488
type: UnificationXref
id: P50151
db: uniprot

VAChT
type: Protein
entity reference: VAChT
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa8 577
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 7668 209
type: UnificationXref
id: 7668
db: ncbitaxon

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot F6UBJ8 180
organism: Xenopus tropicalis

uniprot F1PZI9 353
type: UnificationXref
id: F1PZI9
db: uniprot

uniprot Q3Y3Z2 99
type: UnificationXref
id: Q3Y3Z2
db: uniprot

Syntaxin-1A
type: ProteinReference
xref: PTHR19957:SF84
xref: uniprot P32851 221
organism: Rattus norvegicus

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot P00514 50
xref: PTHR11635:SF129
organism: Bos taurus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P00515 51
organism: Bos taurus

PTHR24353:SF128
type: RelationshipXref
id: PTHR24353:SF128
db: PANTHER Family
relationship type: By Homology

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P00517 52
xref: PTHR24353:SF82
organism: Bos taurus

uniprot O14662 206
type: UnificationXref
id: O14662
db: uniprot

uniprot Q7Q6D3 544
type: UnificationXref
id: Q7Q6D3
db: uniprot

uniprot P63044 237
type: UnificationXref
id: P63044
db: uniprot

uniprot F6WTY3 333
type: UnificationXref
id: F6WTY3
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__ACh-RIGHT__ACh-_r81
control type: ACTIVATION
controller: SNARE COMPLEX

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 31

uniprot P12369 68
type: UnificationXref
id: P12369
db: uniprot

ACh
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa9 579
cellular location: synaptic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7AE17 453
organism: Pan troglodytes

cAMP-dependent protein kinase type 3
type: ProteinReference
xref: PTHR24353:SF73
xref: uniprot P05986 56
organism: Saccharomyces cerevisiae

uniprot K7AE17 453
type: UnificationXref
id: K7AE17
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 388
organism: Gallus gallus

uniprot Q9W3J1 559
type: UnificationXref
id: Q9W3J1
db: uniprot

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 553

ncbitaxon 559292 57
type: UnificationXref
id: 559292
db: ncbitaxon

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: uniprot P05987 58
xref: PTHR11635:SF152
organism: Dictyostelium discoideum

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot F6VUT7 184
organism: Ornithorhynchus anatinus

Synaptosomal-associated protein 23
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot O00161 203
organism: Homo sapiens

Guanylyl cyclase
type: ProteinReference
xref: PTHR43642:SF2
xref: uniprot Q551V8 318
organism: Dictyostelium discoideum

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot C3ZRW7 299
xref: PTHR11559:SF397
organism: Branchiostoma floridae

G protein subunit alpha transducin 2
type: ProteinReference
xref: PTHR10218:SF68
xref: uniprot F6W0P2 416
organism: Monodelphis domestica

PTHR24353:SF117
type: RelationshipXref
id: PTHR24353:SF117
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF116
type: RelationshipXref
id: PTHR24353:SF116
db: PANTHER Family
relationship type: By Homology

uniprot F7G3J2 436
type: UnificationXref
id: F7G3J2
db: uniprot

uniprot Q27687 96
type: UnificationXref
id: Q27687
db: uniprot

uniprot F1P977 404
type: UnificationXref
id: F1P977
db: uniprot

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
type: ProteinReference
xref: uniprot A3KMS9 10
xref: PTHR24353:SF82
organism: Danio rerio

uniprot C3XY80 383
type: UnificationXref
id: C3XY80
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot H2RI77 47
xref: PTHR24353:SF128
organism: Pan troglodytes

uniprot F1MYR9 328
type: UnificationXref
id: F1MYR9
db: uniprot

uniprot Q8C0T9 319
type: UnificationXref
id: Q8C0T9
db: uniprot

Complex (CHT1/choline)
type: Complex
component stoichiometry: CHT1 s11 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: choline s12 sa11 STOICHIOMETRY ID COMPLEX
component: CHT1
component: choline
feature: COMPLEX BINDING FEATURE s102 a106 580
feature: COMPLEX BINDING FEATURE s102 a106 582
cellular location: axon terminus

uniprot H2RCB8 201
type: UnificationXref
id: H2RCB8
db: uniprot

uniprot P27791 80
type: UnificationXref
id: P27791
db: uniprot

Muscarinic acetylcholine receptor M4
type: ProteinReference
xref: PTHR24247:SF180
xref: uniprot P32211 145
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 436
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot B2RSH2 380
xref: PTHR10218:SF227
organism: Mus musculus

uniprot Q6PBN9 536
type: UnificationXref
id: Q6PBN9
db: uniprot

Choline O-acetyltransferase
type: ProteinReference
xref: uniprot P28329 132
xref: PTHR22589:SF14
organism: Homo sapiens

PTHR23506:SF13
type: RelationshipXref
id: PTHR23506:SF13
db: PANTHER Family
relationship type: By Homology

Vesicle associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot F1PRG8 176
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P08752 462
xref: PTHR10218:SF73
organism: Mus musculus

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot P08754 464
organism: Homo sapiens

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot P08753 463
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(K) subunit alpha
type: ProteinReference
xref: uniprot F6VL43 415
organism: Macaca mulatta

AGAP004940-PA
type: ProteinReference
xref: uniprot Q7PPI8 109
xref: PTHR11635:SF162
organism: Anopheles gambiae

uniprot O14610 455
type: UnificationXref
id: O14610
db: uniprot

uniprot K7E376 454
type: UnificationXref
id: K7E376
db: uniprot

uniprot B2RSH2 380
type: UnificationXref
id: B2RSH2
db: uniprot

uniprot Q5I0F6 102
type: UnificationXref
id: Q5I0F6
db: uniprot

uniprot P62873 501
type: UnificationXref
id: P62873
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9ERB0 275
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P05132 54
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P05131 53
organism: Bos taurus

Acetylcholinesterase
type: ProteinReference
xref: uniprot P22303 307
organism: Homo sapiens

uniprot Q0V7N0 245
type: UnificationXref
id: Q0V7N0
db: uniprot

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 116

uniprot F7A472 424
type: UnificationXref
id: F7A472
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 557
organism: Homo sapiens

uniprot F1PVZ1 137
type: UnificationXref
id: F1PVZ1
db: uniprot

uniprot Q6PHV0 265
type: UnificationXref
id: Q6PHV0
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot Q10282 517
organism: Schizosaccharomyces pombe

uniprot P62880 504
type: UnificationXref
id: P62880
db: uniprot

uniprot F7CTP1 427
type: UnificationXref
id: F7CTP1
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P38400 482
xref: PTHR10218:SF73
organism: Canis lupus familiaris

uniprot Q9GNR4 122
type: UnificationXref
id: Q9GNR4
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RJB3 397
organism: Canis lupus familiaris

uniprot E2RTQ4 173
type: UnificationXref
id: E2RTQ4
db: uniprot

uniprot F7GQC5 439
type: UnificationXref
id: F7GQC5
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 211

uniprot F6Q503 26
type: UnificationXref
id: F6Q503
db: uniprot

Syntaxin-19
type: ProteinReference
xref: PTHR19957:SF29
xref: uniprot Q8R1Q0 270
organism: Mus musculus

uniprot Q8WSS1 552
type: UnificationXref
id: Q8WSS1
db: uniprot

PARTICIPANT STOICHIOMETRY r79 596
type: Stoichiometry
physical entity: Complex (CHT1/choline)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r82 584
type: Stoichiometry
physical entity: Acetyl CoA
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P18851 471
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r79 595
type: Stoichiometry
physical entity: choline
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r82 585
type: Stoichiometry
physical entity: Acetyl CoA
stoichiometric coefficient: 1.0

Syntaxin-4
type: ProteinReference
xref: uniprot Q08850 244
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit beta-5b
type: ProteinReference
xref: uniprot Q6PBY0 538
organism: Danio rerio

uniprot Q10282 517
type: UnificationXref
id: Q10282
db: uniprot

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot E2RRA1 15
organism: Canis lupus familiaris

Gbeta5
type: ProteinReference
xref: uniprot Q9W3J1 559
organism: Drosophila melanogaster

uniprot Q7PXF7 111
type: UnificationXref
id: Q7PXF7
db: uniprot

PARTICIPANT STOICHIOMETRY r79 594
type: Stoichiometry
physical entity: CHT1
stoichiometric coefficient: 1.0

uniprot F6SED9 179
type: UnificationXref
id: F6SED9
db: uniprot

PTHR45701:SF6
type: RelationshipXref
id: PTHR45701:SF6
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF7
type: RelationshipXref
id: PTHR45701:SF7
db: PANTHER Family
relationship type: By Homology

uniprot F7DJJ2 138
type: UnificationXref
id: F7DJJ2
db: uniprot

uniprot P23763 219
type: UnificationXref
id: P23763
db: uniprot

G protein subunit gamma 5
type: ProteinReference
xref: uniprot H2PZA6 443
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1PJE5 405
organism: Canis lupus familiaris

uniprot H2QNS5 450
type: UnificationXref
id: H2QNS5
db: uniprot

PTHR45701:SF5
type: RelationshipXref
id: PTHR45701:SF5
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF3
type: RelationshipXref
id: PTHR45701:SF3
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF1
type: RelationshipXref
id: PTHR45701:SF1
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot Q9UK08 558
organism: Homo sapiens

STATE_TRANSITION_LEFT__GIRK-RIGHT__GIRK-_r71
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 610
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 611
left: GIRK
interaction type: STATE_TRANSITION
right: GIRK

uniprot F7BB02 425
type: UnificationXref
id: F7BB02
db: uniprot

uniprot Q9DC51 556
type: UnificationXref
id: Q9DC51
db: uniprot

CHT1
type: ProteinReference
xref: P01084
standard name: high affinity choline transporter
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: high affinity choline transporter Synonym: cht1 Accession: P01084
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 2 and 4 signaling pathway.PROTEIN.GENERIC.CHT1
member entity reference: High-affinity choline transporter 1
member entity reference: Sodium-dependent acetylcholine transporter
member entity reference: AGAP002366-PA
member entity reference: Sodium- and chloride-dependent creatine transporter 1
member entity reference: Protein CBR-CHO-1
member entity reference: Uncharacterized protein
member entity reference: High affinity choline transporter 1
member entity reference: Solute carrier family 6 member 8
member entity reference: Solute carrier family 5 (Choline transporter), member 7
member entity reference: Solute carrier family 5 member 7
member entity reference: High affinity choline transporter
member entity reference: SLC5A7 isoform 1

G Protein s2 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

uniprot F6Q9S4 28
type: UnificationXref
id: F6Q9S4
db: uniprot

uniprot H2RAF8 129
type: UnificationXref
id: H2RAF8
db: uniprot

uniprot P63214 510
type: UnificationXref
id: P63214
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 11

uniprot E2R2S3 390
type: UnificationXref
id: E2R2S3
db: uniprot

PTHR23506:SF23
type: RelationshipXref
id: PTHR23506:SF23
db: PANTHER Family
relationship type: By Homology

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot Q8MJ44 117
organism: Canis lupus familiaris

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P13861 72
organism: Homo sapiens

uniprot Q28300 520
type: UnificationXref
id: Q28300
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E9GNI4 23
xref: PTHR24353:SF117
organism: Daphnia pulex

uniprot F6WIC7 332
type: UnificationXref
id: F6WIC7
db: uniprot

uniprot Q9N0Y0 277
type: UnificationXref
id: Q9N0Y0
db: uniprot

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot A0A2J8Q8V8 294
xref: PTHR11559:SF397
organism: Pan troglodytes

uniprot Q61016 531
type: UnificationXref
id: Q61016
db: uniprot

Syntaxin-3
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot Q08849 243
organism: Rattus norvegicus

Cholinesterase
type: ProteinReference
xref: uniprot Q03311 311
organism: Mus musculus

ncbitaxon 8364 33
type: UnificationXref
id: 8364
db: ncbitaxon

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 370
organism: Pan troglodytes

uniprot A0A2J8J6W3 350
type: UnificationXref
id: A0A2J8J6W3
db: uniprot

uniprot P05131 53
type: UnificationXref
id: P05131
db: uniprot

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q17QQ3 250
organism: Bos taurus

Syntaxin 1B
type: ProteinReference
xref: uniprot F6WJB1 186
xref: PTHR19957:SF334
organism: Monodelphis domestica

uniprot A7EDU2 376
type: UnificationXref
id: A7EDU2
db: uniprot

uniprot P22694 79
type: UnificationXref
id: P22694
db: uniprot

uniprot P26308 476
type: UnificationXref
id: P26308
db: uniprot

uniprot E1BIQ3 169
type: UnificationXref
id: E1BIQ3
db: uniprot

mAChR2 4 s7 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mAChR2/4
stoichiometric coefficient: 1.0

Solute carrier family 5 (Choline transporter), member 7
type: ProteinReference
xref: uniprot Q2KI26 359
organism: Bos taurus

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 5

uniprot P62879 503
type: UnificationXref
id: P62879
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot Q9N0Y0 277
organism: Macaca mulatta

Potassium voltage-gated channel subfamily J member 9
type: ProteinReference
xref: uniprot A0A3Q1MHN1 323
xref: PTHR11767:SF17
organism: Bos taurus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P36975 223
xref: PTHR19305:SF14
organism: Drosophila melanogaster

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q3T0Y8 257
xref: PTHR45701:SF7
organism: Bos taurus

uniprot Q9S7P9 278
type: UnificationXref
id: Q9S7P9
db: uniprot

PARTICIPANT STOICHIOMETRY r80 598
type: Stoichiometry
physical entity: choline
stoichiometric coefficient: 1.0

uniprot E2RHY4 396
type: UnificationXref
id: E2RHY4
db: uniprot

PTHR22589:SF14
type: RelationshipXref
id: PTHR22589:SF14
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r80 597
type: Stoichiometry
physical entity: Complex (CHT1/choline)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r80 599
type: Stoichiometry
physical entity: CHT1
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 422
organism: Monodelphis domestica

uniprot P68182 91
type: UnificationXref
id: P68182
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q15836 248
organism: Homo sapiens

ncbitaxon 9258 185
type: UnificationXref
id: 9258
db: ncbitaxon

G protein-activated inward rectifier potassium channel 3
type: ProteinReference
xref: uniprot Q63511 347
xref: PTHR11767:SF17
organism: Rattus norvegicus

uniprot F1PRG8 176
type: UnificationXref
id: F1PRG8
db: uniprot

uniprot P50154 490
type: UnificationXref
id: P50154
db: uniprot

Solute carrier family 6 member 8
type: ProteinReference
xref: uniprot F1PZI9 353
organism: Canis lupus familiaris

uniprot P38433 310
type: UnificationXref
id: P38433
db: uniprot

uniprot Q388U5 97
type: UnificationXref
id: Q388U5
db: uniprot

muscle contraction
type: Pathway

uniprot Q8EZ52 320
type: UnificationXref
id: Q8EZ52
db: uniprot

VAChT s9 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: VAChT
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P63097 509
organism: Bos taurus

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot P63096 508
xref: PTHR10218:SF227
organism: Homo sapiens

uniprot P32738 133
type: UnificationXref
id: P32738
db: uniprot

uniprot F6V9G5 182
type: UnificationXref
id: F6V9G5
db: uniprot

uniprot Q9LMG8 276
type: UnificationXref
id: Q9LMG8
db: uniprot

Synaptosomal-associated protein 25-B
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q6PC54 264
organism: Danio rerio

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot O44419 208
organism: Strongylocentrotus purpuratus

AC
type: Protein
entity reference: AC
feature: ACTIVE 123
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__Acetyl_CoA-_choline-RIGHT__ACh-_r56
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 624
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 623
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 625
left: choline
left: Acetyl CoA
interaction type: HETERODIMER_ASSOCIATION
right: ACh

ncbitaxon 237631 5
type: UnificationXref
id: 237631
db: ncbitaxon

Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
type: ProteinReference
xref: uniprot Q6DH55 534
organism: Danio rerio

ncbitaxon 36329 217
type: UnificationXref
id: 36329
db: ncbitaxon

uniprot A8WQR8 351
type: UnificationXref
id: A8WQR8
db: uniprot

ACh
type: SmallMolecule
cellular location: synaptic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 189518 116
type: UnificationXref
id: 189518
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6TFY2 411
organism: Macaca mulatta

uniprot F6VKI4 414
type: UnificationXref
id: F6VKI4
db: uniprot

uniprot Q3T0Y8 257
type: UnificationXref
id: Q3T0Y8
db: uniprot

uniprot F6ZIZ9 423
type: UnificationXref
id: F6ZIZ9
db: uniprot

DISSOCIATION_LEFT__Complex__VAChT_ACh_-RIGHT__ACh-_VAChT-_r78
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 601
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 600
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 602
left: Complex (VAChT/ACh)
interaction type: DISSOCIATION
right: ACh
right: VAChT

ncbitaxon 665079 377
type: UnificationXref
id: 665079
db: ncbitaxon

uniprot P13861 72
type: UnificationXref
id: P13861
db: uniprot

uniprot P61264 230
type: UnificationXref
id: P61264
db: uniprot

uniprot F6Y3N2 420
type: UnificationXref
id: F6Y3N2
db: uniprot

uniprot F7A943 190
type: UnificationXref
id: F7A943
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q62442 261
organism: Mus musculus

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 67

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa2 565
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=PROTEIN

uniprot R4GKD1 560
type: UnificationXref
id: R4GKD1
db: uniprot

G protein subunit alpha transducin 1
type: ProteinReference
xref: uniprot D3ZSS5 386
xref: PTHR10218:SF67
organism: Rattus norvegicus

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 24

INHIBITION
type: RelationshipTypeVocabulary

uniprot E1BNE9 324
type: UnificationXref
id: E1BNE9
db: uniprot

uniprot F7G7I9 437
type: UnificationXref
id: F7G7I9
db: uniprot

ncbitaxon 10090 55
type: UnificationXref
id: 10090
db: ncbitaxon

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot Q9DBC7 121
xref: PTHR11635:SF129
organism: Mus musculus

ncbitaxon 9913 29
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot A0A1D5QYR9 161
type: UnificationXref
id: A0A1D5QYR9
db: uniprot

cAMP-dependent protein kinase type 2
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot P06245 61
organism: Saccharomyces cerevisiae

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63078 507
organism: Mus musculus

cAMP-dependent protein kinase type 1
type: ProteinReference
xref: uniprot P06244 60
xref: PTHR24353:SF73
organism: Saccharomyces cerevisiae

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 506
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P09471 465
organism: Homo sapiens

uniprot Q9N2A7 148
type: UnificationXref
id: Q9N2A7
db: uniprot

uniprot O96189 216
type: UnificationXref
id: O96189
db: uniprot

mAChR2 4 s6 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mAChR2/4
stoichiometric coefficient: 1.0

LD03592p
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9W1I8 287
organism: Drosophila melanogaster

Syntaxin 1A
type: ProteinReference
xref: PTHR19957:SF84
xref: uniprot F1PVP1 177
organism: Canis lupus familiaris

AChE
type: Protein
entity reference: AChE
comment: SPECIES_TYPE=PROTEIN

uniprot F6WNJ9 417
type: UnificationXref
id: F6WNJ9
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 493
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 492
organism: Rattus norvegicus

uniprot P48544 341
type: UnificationXref
id: P48544
db: uniprot

Putative SNAP25 homologous protein SNAP30
type: ProteinReference
xref: uniprot Q9LMG8 276
organism: Arabidopsis thaliana

GTP
type: SmallMolecule
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8BGY9 363
type: UnificationXref
id: Q8BGY9
db: uniprot

uniprot Q16623 249
type: UnificationXref
id: Q16623
db: uniprot

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot E2RP98 300
xref: PTHR11559:SF397
organism: Canis lupus familiaris

uniprot P36975 223
type: UnificationXref
id: P36975
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 429
organism: Ornithorhynchus anatinus

Complex (mAChR2/4/ ACh)
type: Complex
component stoichiometry: mAChR2 4 s7 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: ACh s8 sa7 STOICHIOMETRY ID COMPLEX
component: mAChR2/4
component: ACh
feature: COMPLEX BINDING FEATURE s65 a73 574
feature: COMPLEX BINDING FEATURE s65 a73 572
cellular location: heart muscle or neuron cytosol, or nerve terminal c2

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q0V7N0 245
organism: Bos taurus

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot Q7T3D3 548
organism: Danio rerio

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 539
organism: Danio rerio

uniprot F6YFY5 421
type: UnificationXref
id: F6YFY5
db: uniprot

PTHR19957:SF29
type: RelationshipXref
id: PTHR19957:SF29
db: PANTHER Family
relationship type: By Homology

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa1 563
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2PZK9 444
type: UnificationXref
id: H2PZK9
db: uniprot

mAChR2/4
type: ProteinReference
xref: P01077
standard name: Muscarinic acetylcholine receptor 2 and 4
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 2 and 4 signaling pathway.PROTEIN.RECEPTOR.mAChR2/4
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Muscarinic acetylcholine receptor M2
member entity reference: Muscarinic acetylcholine receptor M4
member entity reference: Muscarinic acetylcholine receptor
member entity reference: Muscarinic acetylcholine receptor M2 (Fragment)

uniprot P28570 357
type: UnificationXref
id: P28570
db: uniprot

uniprot P60878 227
type: UnificationXref
id: P60878
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 401

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF68
xref: uniprot F6VKI4 414
organism: Macaca mulatta

PTHR19957:SF30
type: RelationshipXref
id: PTHR19957:SF30
db: PANTHER Family
relationship type: By Homology

uniprot C3ZSF0 384
type: UnificationXref
id: C3ZSF0
db: uniprot

ACh
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa7 575
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR19957:SF36
type: RelationshipXref
id: PTHR19957:SF36
db: PANTHER Family
relationship type: By Homology

uniprot F7DHW8 334
type: UnificationXref
id: F7DHW8
db: uniprot

uniprot P16905 73
type: UnificationXref
id: P16905
db: uniprot

uniprot Q12846 247
type: UnificationXref
id: Q12846
db: uniprot

uniprot P83351 240
type: UnificationXref
id: P83351
db: uniprot

Guanine nucleotide-binding protein G(t) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF67
xref: uniprot Q28300 520
organism: Canis lupus familiaris

PTHR19957:SF34
type: RelationshipXref
id: PTHR19957:SF34
db: PANTHER Family
relationship type: By Homology

uniprot O95721 215
type: UnificationXref
id: O95721
db: uniprot

uniprot P50153 489
type: UnificationXref
id: P50153
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QIS2 160
xref: PTHR45701:SF7
organism: Macaca mulatta

uniprot H2Q3W7 447
type: UnificationXref
id: H2Q3W7
db: uniprot

uniprot Q0VFR6 246
type: UnificationXref
id: Q0VFR6
db: uniprot

uniprot F6UST7 331
type: UnificationXref
id: F6UST7
db: uniprot

uniprot Q6TH03 540
type: UnificationXref
id: Q6TH03
db: uniprot

uniprot A0A1D5NXG4 158
type: UnificationXref
id: A0A1D5NXG4
db: uniprot

uniprot Q9SD96 279
type: UnificationXref
id: Q9SD96
db: uniprot

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: PTHR11767:SF16
xref: uniprot E1BNE9 324
organism: Bos taurus

uniprot Q9UK08 558
type: UnificationXref
id: Q9UK08
db: uniprot

uniprot Q61011 530
type: UnificationXref
id: Q61011
db: uniprot

Cholinesterase
type: ProteinReference
xref: uniprot P06276 305
organism: Homo sapiens

CHT1 s11 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHT1
stoichiometric coefficient: 1.0

uniprot G5EDV9 303
type: UnificationXref
id: G5EDV9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5NXG4 158
organism: Gallus gallus

VAChT
type: Protein
entity reference: VAChT
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot P34099 85
organism: Dictyostelium discoideum

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

HETERODIMER_ASSOCIATION_LEFT__CHT1-_choline-RIGHT__Complex__CHT1_choline_-_r79
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 596
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 594
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 595
left: choline
left: CHT1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (CHT1/choline)

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot H2Q995 196
xref: PTHR19305:SF4
organism: Pan troglodytes

uniprot P39926 224
type: UnificationXref
id: P39926
db: uniprot

cAMP-dependent protein kinase catalytic subunit 3
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot P16912 74
organism: Drosophila melanogaster

uniprot P30625 81
type: UnificationXref
id: P30625
db: uniprot

uniprot Q3ZCA7 524
type: UnificationXref
id: Q3ZCA7
db: uniprot

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot G5EDN1 302
organism: Caenorhabditis elegans

uniprot P20353 474
type: UnificationXref
id: P20353
db: uniprot

Syntaxin 16
type: ProteinReference
xref: uniprot A0A0G2K528 157
organism: Rattus norvegicus

Guanine nucleotide-binding protein (G protein), beta 5
type: ProteinReference
xref: uniprot F7EBE7 430
organism: Xenopus tropicalis

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P16520 469
organism: Homo sapiens

uniprot P08754 464
type: UnificationXref
id: P08754
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6V461 413
organism: Ornithorhynchus anatinus

uniprot F6VUT7 184
type: UnificationXref
id: F6VUT7
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 40

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RR72 172
organism: Canis lupus familiaris

cAMP-dependent protein kinase type I regulatory subunit
type: ProteinReference
xref: uniprot P16905 73
xref: PTHR11635:SF152
organism: Drosophila melanogaster

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6PBR4 537
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DGZ5 533
organism: Danio rerio

Protein kinase, cAMP-dependent, catalytic, beta
type: ProteinReference
xref: uniprot Q3ZB92 100
xref: PTHR24353:SF116
organism: Danio rerio

uniprot G3V8K2 442
type: UnificationXref
id: G3V8K2
db: uniprot

uniprot A0A2J8P954 371
type: UnificationXref
id: A0A2J8P954
db: uniprot

uniprot P20612 475
type: UnificationXref
id: P20612
db: uniprot

uniprot P22612 78
type: UnificationXref
id: P22612
db: uniprot

ncbitaxon 9031 9
type: UnificationXref
id: 9031
db: ncbitaxon

Protein kinase A catalytic subunit isoform 1
type: ProteinReference
xref: uniprot Q9GNR4 122
xref: PTHR24353:SF67
organism: Leishmania major

Choline O-acetyltransferase
type: ProteinReference
xref: uniprot Q03059 135
xref: PTHR22589:SF14
organism: Mus musculus

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot A0A2I3SR99 162
xref: PTHR45701:SF7
organism: Pan troglodytes

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot A0A1D5QYR9 161
organism: Macaca mulatta

uniprot F2Z3T8 406
type: UnificationXref
id: F2Z3T8
db: uniprot

uniprot A0A2I3TFM8 369
type: UnificationXref
id: A0A2I3TFM8
db: uniprot

uniprot A3KMS9 10
type: UnificationXref
id: A3KMS9
db: uniprot

uniprot P04695 458
type: UnificationXref
id: P04695
db: uniprot

VAChT
type: ProteinReference
xref: P01078
standard name: vesicular acetylcholine transporter
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 2 and 4 signaling pathway.PROTEIN.GENERIC.VAChT
comment: ENTITY_REFERENCE_NOTES= Long Name: vesicular acetylcholine transporter Synonym: CG32848,VAChT Accession: P01078
member entity reference: Portabella
member entity reference: Uncharacterized MFS-type transporter C18.02
member entity reference: Vesicular acetylcholine transporter
member entity reference: AGAP002369-PA
member entity reference: AGAP003684-PA
member entity reference: SLC18A3 isoform 1

Gi alpha subunit
type: ProteinReference
xref: PTHR10218:SF310
xref: uniprot C3XY80 383
organism: Branchiostoma floridae

Solute carrier family 5 member 7
type: ProteinReference
xref: uniprot E2RAJ0 352
organism: Canis lupus familiaris

uniprot E9FUX0 398
type: UnificationXref
id: E9FUX0
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot F7FXA9 435
organism: Macaca mulatta

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2b
type: ProteinReference
xref: uniprot X1WDQ5 561
xref: PTHR10218:SF73
organism: Danio rerio

ncbitaxon 243090 362
type: UnificationXref
id: 243090
db: ncbitaxon

uniprot F6S570 330
type: UnificationXref
id: F6S570
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot P29387 477
organism: Mus musculus

Sodium- and chloride-dependent creatine transporter 1
type: ProteinReference
xref: uniprot Q8VBW1 364
organism: Mus musculus

ncbitaxon 7719 553
type: UnificationXref
id: 7719
db: ncbitaxon

uniprot Q9VCJ5 156
type: UnificationXref
id: Q9VCJ5
db: uniprot

Syntaxin-42
type: ProteinReference
xref: uniprot Q9SWH4 282
organism: Arabidopsis thaliana

uniprot F6YMH2 188
type: UnificationXref
id: F6YMH2
db: uniprot

ncbitaxon 9606 64
type: UnificationXref
id: 9606
db: ncbitaxon

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 525
organism: Danio rerio

Syntaxin-1A
type: ProteinReference
xref: uniprot Q24547 254
organism: Drosophila melanogaster

uniprot Q5ZM91 105
type: UnificationXref
id: Q5ZM91
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6S570 330
xref: PTHR11767:SF19
organism: Monodelphis domestica

uniprot A0A452DIB2 164
type: UnificationXref
id: A0A452DIB2
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 57

uniprot Q15836 248
type: UnificationXref
id: Q15836
db: uniprot

uniprot E2RGI5 395
type: UnificationXref
id: E2RGI5
db: uniprot

Syntaxin-16
type: ProteinReference
xref: uniprot O14662 206
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot G5EB66 39
xref: PTHR24353:SF117
organism: Emericella nidulans

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 70

uniprot P54311 492
type: UnificationXref
id: P54311
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 530
organism: Mus musculus

uniprot F6T0T9 32
type: UnificationXref
id: F6T0T9
db: uniprot

uniprot G5EEN8 195
type: UnificationXref
id: G5EEN8
db: uniprot

uniprot A8XL40 296
type: UnificationXref
id: A8XL40
db: uniprot

Syntaxin-4
type: ProteinReference
xref: uniprot P70452 239
organism: Mus musculus

uniprot F1PJE5 405
type: UnificationXref
id: F1PJE5
db: uniprot

uniprot P08753 463
type: UnificationXref
id: P08753
db: uniprot

uniprot P05986 56
type: UnificationXref
id: P05986
db: uniprot

uniprot P48550 344
type: UnificationXref
id: P48550
db: uniprot

uniprot P12367 65
type: UnificationXref
id: P12367
db: uniprot

uniprot Q92356 272
type: UnificationXref
id: Q92356
db: uniprot

uniprot P29387 477
type: UnificationXref
id: P29387
db: uniprot

uniprot F6UBJ8 180
type: UnificationXref
id: F6UBJ8
db: uniprot

AGAP001506-PA
type: ProteinReference
xref: uniprot Q7PXP3 542
organism: Anopheles gambiae

uniprot P70452 239
type: UnificationXref
id: P70452
db: uniprot

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 217

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 531
organism: Mus musculus

PTHR10218:SF227
type: RelationshipXref
id: PTHR10218:SF227
db: PANTHER Family
relationship type: By Homology

uniprot H2QLA1 197
type: UnificationXref
id: H2QLA1
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot Q61017 532
organism: Mus musculus

uniprot F6V461 413
type: UnificationXref
id: F6V461
db: uniprot

uniprot E9H7Z0 399
type: UnificationXref
id: E9H7Z0
db: uniprot

uniprot Q9TY08 283
type: UnificationXref
id: Q9TY08
db: uniprot

Syntaxin-19
type: ProteinReference
xref: uniprot Q8N4C7 269
xref: PTHR19957:SF29
organism: Homo sapiens

SLC5A7 isoform 1
type: ProteinReference
xref: uniprot A0A2J8J6W3 350
organism: Pan troglodytes

Adenylate cyclase type 10
type: ProteinReference
xref: uniprot Q96PN6 321
xref: PTHR16305:SF28
organism: Homo sapiens

uniprot F1MLQ5 125
type: UnificationXref
id: F1MLQ5
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9Z2P6 289
organism: Rattus norvegicus

CAP family transcription factor
type: ProteinReference
xref: PTHR11635:SF157
xref: uniprot Q8CXT1 115
organism: Leptospira interrogans

uniprot E2R907 171
type: UnificationXref
id: E2R907
db: uniprot

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q9WUF4 288
organism: Rattus norvegicus

Carboxylic ester hydrolase
type: ProteinReference
xref: PTHR43918:SF5
xref: uniprot Q7QFG0 312
organism: Anopheles gambiae

PTHR23506:SF4
type: RelationshipXref
id: PTHR23506:SF4
db: PANTHER Family
relationship type: By Homology

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q5R1X1 259
organism: Pan troglodytes

uniprot P08172 139
type: UnificationXref
id: P08172
db: uniprot

synaptic vesicle
type: CellularLocationVocabulary
xref: GO GO:0008021 2

PTHR10218:SF230
type: RelationshipXref
id: PTHR10218:SF230
db: PANTHER Family
relationship type: By Homology

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot P10644 63
xref: PTHR11635:SF129
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6PBN9 536
organism: Danio rerio

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 33

uniprot P12849 71
type: UnificationXref
id: P12849
db: uniprot

GIRK
type: ProteinReference
xref: P01083
standard name: G protein-coupled inwardly rectifying potassium channel
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES= Long Name: G protein-coupled inwardly rectifying potassium channel Synonym: GIRK Accession: P01083
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 2 and 4 signaling pathway.PROTEIN.ION_CHANNEL.GIRK
member entity reference: G protein-activated inward rectifier potassium channel 2
member entity reference: Potassium voltage-gated channel subfamily J member 6
member entity reference: G protein-activated inward rectifier potassium channel 3
member entity reference: Uncharacterized protein
member entity reference: G protein-activated inward rectifier potassium channel 4
member entity reference: G protein-activated inward rectifier potassium channel 1
member entity reference: Potassium voltage-gated channel subfamily J member 9
member entity reference: Potassium channel, inwardly rectifying subfamily J, member 3
member entity reference: Potassium voltage-gated channel subfamily J member 5
member entity reference: Potassium voltage-gated channel subfamily J member 3
member entity reference: KCNJ3 isoform 1

uniprot Q01386 93
type: UnificationXref
id: Q01386
db: uniprot

uniprot Q9VH76 285
type: UnificationXref
id: Q9VH76
db: uniprot

uniprot P91409 241
type: UnificationXref
id: P91409
db: uniprot

Acetylcholinesterase
type: ProteinReference
xref: uniprot P21836 306
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q922R0 120
organism: Mus musculus

TRIGGER
type: RelationshipTypeVocabulary

Complex (GTP/G-Protein)
type: Complex
component stoichiometry: GTP s1 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s2 sa5 STOICHIOMETRY ID COMPLEX
component: GTP
component: G-Protein
feature: COMPLEX BINDING FEATURE s59 a65 568
feature: ACTIVE 123
feature: COMPLEX BINDING FEATURE s59 a65 570
cellular location: heart muscle or neuron cytosol, or nerve terminal c2

Adenylate/guanylate cyclase
type: ProteinReference
xref: PTHR16305:SF28
xref: uniprot Q8EZ52 320
organism: Leptospira interrogans

choline
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa11 583
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

uniprot F7CXD0 428
type: UnificationXref
id: F7CXD0
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot O14610 455
organism: Homo sapiens

uniprot Q90854 348
type: UnificationXref
id: Q90854
db: uniprot

uniprot P06244 60
type: UnificationXref
id: P06244
db: uniprot

uniprot Q90Z40 554
type: UnificationXref
id: Q90Z40
db: uniprot

uniprot O64791 210
type: UnificationXref
id: O64791
db: uniprot

uniprot Q7PR83 155
type: UnificationXref
id: Q7PR83
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P49177 484
organism: Arabidopsis thaliana

cAMP-dependent protein kinase, catalytic subunit-like
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q7JP68 108
organism: Caenorhabditis elegans

TRANSPORT_LEFT__Acetyl_CoA-RIGHT__Acetyl_CoA-_r82
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 585
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 584
left: Acetyl CoA
interaction type: TRANSPORT
right: Acetyl CoA

uniprot Q63511 347
type: UnificationXref
id: Q63511
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P30625 81
organism: Caenorhabditis elegans

Choline O-acetyltransferase
type: ProteinReference
xref: PTHR22589:SF14
xref: uniprot F1P393 126
organism: Gallus gallus

uniprot P18851 471
type: UnificationXref
id: P18851
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 466
organism: Bos taurus

Syntaxin 16
type: ProteinReference
xref: uniprot Q9VR90 286
organism: Drosophila melanogaster

uniprot Q7KVY7 266
type: UnificationXref
id: Q7KVY7
db: uniprot

uniprot P10644 63
type: UnificationXref
id: P10644
db: uniprot

uniprot Q62666 154
type: UnificationXref
id: Q62666
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot F7H6T2 37
organism: Macaca mulatta

uniprot P04899 461
type: UnificationXref
id: P04899
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T7 440
organism: Macaca mulatta

uniprot P31321 82
type: UnificationXref
id: P31321
db: uniprot

uniprot F6PVT7 409
type: UnificationXref
id: F6PVT7
db: uniprot

uniprot Q9W1I8 287
type: UnificationXref
id: Q9W1I8
db: uniprot

uniprot P48545 342
type: UnificationXref
id: P48545
db: uniprot

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r70
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 616
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 617
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

PARTICIPANT STOICHIOMETRY r78 602
type: Stoichiometry
physical entity: VAChT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r78 601
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

Protein kinase, cAMP-dependent, regulatory, type II, alpha, B
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot Q6NW93 107
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r78 600
type: Stoichiometry
physical entity: Complex (VAChT/ACh)
stoichiometric coefficient: 1.0

uniprot H2QUY0 451
type: UnificationXref
id: H2QUY0
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QUY0 451
organism: Pan troglodytes

uniprot H2QNP1 304
type: UnificationXref
id: H2QNP1
db: uniprot

Vesicle associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot E2QUL2 170
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(O) subunit alpha isoform a
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot F7GQC5 439
organism: Macaca mulatta

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot F5HH30 407
organism: Neurospora crassa

uniprot Q7PXP3 542
type: UnificationXref
id: Q7PXP3
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P43425 483
organism: Rattus norvegicus

Protein kinase, X-linked
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q5BK52 101
organism: Rattus norvegicus

uniprot Q6DH55 534
type: UnificationXref
id: Q6DH55
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IGZ2 374
organism: Xenopus tropicalis

uniprot F7HPD8 301
type: UnificationXref
id: F7HPD8
db: uniprot

PARTICIPANT STOICHIOMETRY r71 611
type: Stoichiometry
physical entity: GIRK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r71 610
type: Stoichiometry
physical entity: GIRK
stoichiometric coefficient: 1.0

uniprot Q3SZ98 523
type: UnificationXref
id: Q3SZ98
db: uniprot

AGAP003684-PA
type: ProteinReference
xref: uniprot A0NDL1 149
xref: PTHR23506:SF4
organism: Anopheles gambiae

ncbitaxon 6239 77
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot Q7Q8S4 547
type: UnificationXref
id: Q7Q8S4
db: uniprot

uniprot F1NLV4 403
type: UnificationXref
id: F1NLV4
db: uniprot

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot Q5ZM91 105
xref: PTHR11635:SF129
organism: Gallus gallus

ncbitaxon 44689 59
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot O70404 213
type: UnificationXref
id: O70404
db: uniprot

Sodium- and chloride-dependent creatine transporter 1
type: ProteinReference
xref: uniprot P48029 358
organism: Homo sapiens

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot H2QNP1 304
xref: PTHR43918:SF5
organism: Pan troglodytes

Protein kinase, cAMP-dependent, regulatory, type I, beta
type: ProteinReference
xref: uniprot Q08C49 95
xref: PTHR11635:SF126
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XWE8 419
organism: Monodelphis domestica

uniprot F7F580 433
type: UnificationXref
id: F7F580
db: uniprot

PKA
type: ProteinReference
xref: P01075
standard name: Protein kinase A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 2 and 4 signaling pathway.PROTEIN.GENERIC.PKA
comment: ENTITY_REFERENCE_NOTES= Long Name: Protein Kinase A Synonym: PKA Accession: P01075
member entity reference: Protein kinase A catalytic subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit beta
member entity reference: cAMP-dependent protein kinase regulatory subunit
member entity reference: AGAP011840-PA (Fragment)
member entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit
member entity reference: cGMP-dependent 3',5'-cGMP phosphodiesterase A
member entity reference: Protein kinase A catalytic subunit isoform 1
member entity reference: Protein kinase cAMP-dependent type I regulatory subunit alpha
member entity reference: Protein kinase A catalytic subunit isoform 2
member entity reference: Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit beta
member entity reference: Protein kinase cAMP-activated catalytic subunit beta
member entity reference: cAMP-dependent protein kinase type I regulatory subunit
member entity reference: cAMP-dependent protein kinase type 3
member entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit
member entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha
member entity reference: cAMP-dependent protein kinase catalytic subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit 3
member entity reference: cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B
member entity reference: Uncharacterized protein
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta a
member entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit beta isoform 1
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha isoform 1
member entity reference: PRKAR2A isoform 1
member entity reference: Protein kinase, cAMP-dependent, regulatory, type II, alpha, B
member entity reference: PRKAR1A isoform 12
member entity reference: AGAP004940-PA
member entity reference: Protein kinase, cAMP-dependent, regulatory, type I, beta
member entity reference: cAMP-dependent protein kinase catalytic subunit gamma
member entity reference: cAMP-dependent protein kinase type II regulatory subunit
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
member entity reference: AGAP001384-PA
member entity reference: Protein kinase cAMP-activated catalytic subunit alpha
member entity reference: Protein serine/threonine kinase, putative
member entity reference: Kinase, AGC PKA
member entity reference: Protein kinase, X-linked
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit alpha
member entity reference: Prkar1a protein
member entity reference: cAMP-dependent protein kinase catalytic subunit TPK2
member entity reference: cAMP-dependent protein kinase type 1
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
member entity reference: cAMP-dependent protein kinase type 2

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot Q92356 272
organism: Schizosaccharomyces pombe

P01076
type: UnificationXref
id: P01076
db: PANTHER Pathway Component

P01077
type: UnificationXref
id: P01077
db: PANTHER Pathway Component

AGAP005904-PA
type: ProteinReference
xref: PTHR10218:SF310
xref: uniprot Q7Q6E0 546
organism: Anopheles gambiae

P01075
type: UnificationXref
id: P01075
db: PANTHER Pathway Component

Syntaxin-2
type: ProteinReference
xref: uniprot P50279 225
organism: Rattus norvegicus

uniprot Q9JKC1 314
type: UnificationXref
id: Q9JKC1
db: uniprot

P01078
type: UnificationXref
id: P01078
db: PANTHER Pathway Component

P01079
type: UnificationXref
id: P01079
db: PANTHER Pathway Component

ACh s8 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

AGAP005911-PA
type: ProteinReference
xref: uniprot Q7Q6D4 545
organism: Anopheles gambiae

uniprot Q551V8 318
type: UnificationXref
id: Q551V8
db: uniprot

AGAP005913-PA
type: ProteinReference
xref: uniprot Q7Q6D2 543
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UJE8 412
xref: PTHR10218:SF227
organism: Monodelphis domestica

AGAP005912-PA
type: ProteinReference
xref: uniprot Q7Q6D3 544
organism: Anopheles gambiae

uniprot F6XWE8 419
type: UnificationXref
id: F6XWE8
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 29

uniprot P50149 486
type: UnificationXref
id: P50149
db: uniprot

uniprot Q96PN6 321
type: UnificationXref
id: Q96PN6
db: uniprot

uniprot F7H6T7 440
type: UnificationXref
id: F7H6T7
db: uniprot

ACh
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 185

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_r73
control type: ACTIVATION
controller: GIRK

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q3W7 447
organism: Pan troglodytes

uniprot O44419 208
type: UnificationXref
id: O44419
db: uniprot

PTHR43642:SF2
type: RelationshipXref
id: PTHR43642:SF2
db: PANTHER Family
relationship type: By Homology

uniprot H2RI77 47
type: UnificationXref
id: H2RI77
db: uniprot

uniprot P60877 226
type: UnificationXref
id: P60877
db: uniprot

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Acetyl_CoA-_choline-RIGHT__ACh-_r56
controller: CAT

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot P40376 88
xref: PTHR24353:SF117
organism: Schizosaccharomyces pombe

Syntaxin family protein
type: ProteinReference
xref: uniprot V5IKK0 292
organism: Neurospora crassa

uniprot F6YZA3 422
type: UnificationXref
id: F6YZA3
db: uniprot

uniprot O16992 130
type: UnificationXref
id: O16992
db: uniprot

uniprot P63217 513
type: UnificationXref
id: P63217
db: uniprot

uniprot P61954 498
type: UnificationXref
id: P61954
db: uniprot

uniprot E2R9G5 393
type: UnificationXref
id: E2R9G5
db: uniprot

uniprot F7ES15 193
type: UnificationXref
id: F7ES15
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q28H40 521
organism: Xenopus tropicalis

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P30671 479
organism: Bos taurus

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P31324 84
organism: Mus musculus

G protein alpha i subunit
type: ProteinReference
xref: PTHR10218:SF310
xref: uniprot P20353 474
organism: Drosophila melanogaster

Syntaxin-121
type: ProteinReference
xref: uniprot Q9ZSD4 291
organism: Arabidopsis thaliana

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 382

Muscarinic acetylcholine receptor M4
type: ProteinReference
xref: PTHR24247:SF180
xref: uniprot P08485 141
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r56 624
type: Stoichiometry
physical entity: choline
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r56 625
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r56 623
type: Stoichiometry
physical entity: Acetyl CoA
stoichiometric coefficient: 1.0

uniprot V5IKK0 292
type: UnificationXref
id: V5IKK0
db: uniprot

Adenylate cyclase type 10
type: ProteinReference
xref: PTHR16305:SF28
xref: uniprot Q8C0T9 319
organism: Mus musculus

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa4 569
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

AGAP008039-PA (Fragment)
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot Q7Q3T7 113
organism: Anopheles gambiae

uniprot E2RRA1 15
type: UnificationXref
id: E2RRA1
db: uniprot

uniprot Q1K7J3 251
type: UnificationXref
id: Q1K7J3
db: uniprot

uniprot F1A421 400
type: UnificationXref
id: F1A421
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot F1A421 400
organism: Dictyostelium purpureum

uniprot P19087 473
type: UnificationXref
id: P19087
db: uniprot

uniprot P63027 236
type: UnificationXref
id: P63027
db: uniprot

cAMP-dependent protein kinase catalytic subunit 1
type: ProteinReference
xref: uniprot P12370 69
xref: PTHR24353:SF117
organism: Drosophila melanogaster

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 16

uniprot F6QHN1 354
type: UnificationXref
id: F6QHN1
db: uniprot

uniprot F6XHP0 418
type: UnificationXref
id: F6XHP0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NGS8 372
organism: Bos taurus

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 450
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7G7I9 437
organism: Ornithorhynchus anatinus

ncbitaxon 7955 11
type: UnificationXref
id: 7955
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r68
controller: cAMP

uniprot A0A0G2K528 157
type: UnificationXref
id: A0A0G2K528
db: uniprot

uniprot A7MBH9 378
type: UnificationXref
id: A7MBH9
db: uniprot

uniprot P48029 358
type: UnificationXref
id: P48029
db: uniprot

VAMP3 isoform 1
type: ProteinReference
xref: uniprot G2HIJ9 194
xref: PTHR45701:SF6
organism: Pan troglodytes

choline
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR45701:SF10
type: RelationshipXref
id: PTHR45701:SF10
db: PANTHER Family
relationship type: By Homology

uniprot O17444 151
type: UnificationXref
id: O17444
db: uniprot

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P31323 83
organism: Homo sapiens

uniprot P63024 233
type: UnificationXref
id: P63024
db: uniprot

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: uniprot P31321 82
xref: PTHR11635:SF126
organism: Homo sapiens

uniprot Q2KI26 359
type: UnificationXref
id: Q2KI26
db: uniprot

uniprot P34099 85
type: UnificationXref
id: P34099
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot E2R907 171
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7CFG8 426
organism: Monodelphis domestica

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 9

uniprot Q8MLZ3 118
type: UnificationXref
id: Q8MLZ3
db: uniprot

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P12369 68
organism: Rattus norvegicus

uniprot Q6DBV8 106
type: UnificationXref
id: Q6DBV8
db: uniprot

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P12367 65
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BIQ3 169
organism: Bos taurus

Acetylcholinesterase 1
type: ProteinReference
xref: uniprot P38433 310
organism: Caenorhabditis elegans

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P12368 66
organism: Rattus norvegicus

uniprot A9JTC8 379
type: UnificationXref
id: A9JTC8
db: uniprot

GO GO:0008021 2
type: UnificationXref
id: GO:0008021
db: GO

uniprot O14775 456
type: UnificationXref
id: O14775
db: uniprot

uniprot A5PEW5 165
type: UnificationXref
id: A5PEW5
db: uniprot

uniprot A8X4Z4 166
type: UnificationXref
id: A8X4Z4
db: uniprot

uniprot A0A3Q1NGS8 372
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

Syntaxin-1B
type: ProteinReference
xref: uniprot P61265 231
xref: PTHR19957:SF334
organism: Rattus norvegicus

ncbitaxon 9544 27
type: UnificationXref
id: 9544
db: ncbitaxon

Syntaxin-1B
type: ProteinReference
xref: uniprot P61264 230
xref: PTHR19957:SF334
organism: Mus musculus

Complex (VAChT/ACh)
type: Complex
component stoichiometry: ACh s10 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: VAChT s9 sa8 STOICHIOMETRY ID COMPLEX
component: VAChT
component: ACh
feature: COMPLEX BINDING FEATURE s99 a103 576
feature: COMPLEX BINDING FEATURE s99 a103 578
cellular location: synaptic vesicle

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7GI54 438
organism: Monodelphis domestica

uniprot C3ZD75 297
type: UnificationXref
id: C3ZD75
db: uniprot

Sodium- and chloride-dependent creatine transporter 1
type: ProteinReference
xref: uniprot P28570 357
organism: Rattus norvegicus

uniprot F6VL43 415
type: UnificationXref
id: F6VL43
db: uniprot

uniprot P48542 339
type: UnificationXref
id: P48542
db: uniprot

uniprot A0A2I3S4R3 368
type: UnificationXref
id: A0A2I3S4R3
db: uniprot

SNAP25 homologous protein SNAP33
type: ProteinReference
xref: uniprot Q9S7P9 278
organism: Arabidopsis thaliana

uniprot Q20636 519
type: UnificationXref
id: Q20636
db: uniprot

Guanine nucleotide-binding protein G(t) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF68
xref: uniprot P19087 473
organism: Homo sapiens

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot Q9VH76 285
xref: PTHR19305:SF14
organism: Drosophila melanogaster

Guanine nucleotide-binding protein subunit gamma-1
type: ProteinReference
xref: uniprot P38040 481
organism: Drosophila melanogaster

PTHR19957:SF84
type: RelationshipXref
id: PTHR19957:SF84
db: PANTHER Family
relationship type: By Homology

Gnb3 protein
type: ProteinReference
xref: uniprot Q6P025 535
organism: Danio rerio

uniprot P08752 462
type: UnificationXref
id: P08752
db: uniprot

uniprot H2Q9G5 448
type: UnificationXref
id: H2Q9G5
db: uniprot

uniprot F6RIM7 410
type: UnificationXref
id: F6RIM7
db: uniprot

mAChR2/4
type: Protein
entity reference: mAChR2/4
feature: mAChR2 4 s7 sa6 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa6 573
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=PROTEIN

uniprot P63096 508
type: UnificationXref
id: P63096
db: uniprot

Guanine nucleotide binding protein, beta subunit
type: ProteinReference
xref: uniprot E9FUX0 398
organism: Daphnia pulex

uniprot F7DNS6 191
type: UnificationXref
id: F7DNS6
db: uniprot

G protein-activated inward rectifier potassium channel 2
type: ProteinReference
xref: uniprot P48051 338
xref: PTHR11767:SF19
organism: Homo sapiens

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: uniprot P51817 89
xref: PTHR24353:SF133
organism: Homo sapiens

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot A8XL40 296
xref: PTHR43918:SF4
organism: Caenorhabditis briggsae

STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_r68
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 614
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 615
left: PKA
interaction type: STATE_TRANSITION
right: PKA

uniprot H9EQQ4 48
type: UnificationXref
id: H9EQQ4
db: uniprot

uniprot P63078 507
type: UnificationXref
id: P63078
db: uniprot

Syntaxin-1B
type: ProteinReference
xref: uniprot P61266 232
xref: PTHR19957:SF334
organism: Homo sapiens

uniprot P04897 460
type: UnificationXref
id: P04897
db: uniprot

uniprot P62874 502
type: UnificationXref
id: P62874
db: uniprot

STX1A isoform 3
type: ProteinReference
xref: PTHR19957:SF84
xref: uniprot H2QUQ1 200
organism: Pan troglodytes

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_r67
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 619
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 618
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

Vesicular acetylcholine transporter
type: ProteinReference
xref: uniprot Q62666 154
organism: Rattus norvegicus

uniprot Q08849 243
type: UnificationXref
id: Q08849
db: uniprot

Guanine nucleotide-binding protein G(t) subunit alpha-1
type: ProteinReference
xref: uniprot P11488 467
xref: PTHR10218:SF67
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 409
organism: Monodelphis domestica

uniprot A8XW88 14
type: UnificationXref
id: A8XW88
db: uniprot

uniprot A0A1D5PCI4 8
type: UnificationXref
id: A0A1D5PCI4
db: uniprot

uniprot Q7Q6E0 546
type: UnificationXref
id: Q7Q6E0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 420
organism: Monodelphis domestica

THO complex subunit, putative
type: ProteinReference
xref: uniprot B7Q3T6 381
organism: Ixodes scapularis

uniprot Q63666 262
type: UnificationXref
id: Q63666
db: uniprot

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: uniprot P81900 92
xref: PTHR11635:SF162
organism: Drosophila melanogaster

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: PTHR24353:SF137
xref: uniprot P22612 78
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XHP0 418
organism: Macaca mulatta

SLC18A3 isoform 1
type: ProteinReference
xref: uniprot H2Q1W2 150
xref: PTHR23506:SF13
organism: Pan troglodytes

ncbitaxon 7227 70
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot F6XYX9 187
type: UnificationXref
id: F6XYX9
db: uniprot

uniprot E2RRD1 17
type: UnificationXref
id: E2RRD1
db: uniprot

Syntaxin-1A isoform 1
type: ProteinReference
xref: PTHR19957:SF84
xref: uniprot A0A1D5QEM1 159
organism: Macaca mulatta

ncbitaxon 6945 382
type: UnificationXref
id: 6945
db: ncbitaxon

Protein CBR-CHA-1
type: ProteinReference
xref: uniprot A8X694 124
xref: PTHR23506:SF23
organism: Caenorhabditis briggsae

Syntaxin-4
type: ProteinReference
xref: uniprot Q12846 247
organism: Homo sapiens

uniprot Q8N4C7 269
type: UnificationXref
id: Q8N4C7
db: uniprot

Sodium-dependent acetylcholine transporter
type: ProteinReference
xref: uniprot O76689 356
organism: Caenorhabditis elegans

uniprot F7EBQ5 35
type: UnificationXref
id: F7EBQ5
db: uniprot

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P26308 476
organism: Drosophila melanogaster

uniprot P63218 514
type: UnificationXref
id: P63218
db: uniprot

P01085
type: UnificationXref
id: P01085
db: PANTHER Pathway Component

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot F6Q9S4 28
xref: PTHR11635:SF156
organism: Bos taurus

Putative syntaxin-3
type: ProteinReference
xref: uniprot Q20024 252
organism: Caenorhabditis elegans

cAMP-dependent protein kinase type 3
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot Q3Y3Z2 99
organism: Neurospora crassa

uniprot Q5TZ66 260
type: UnificationXref
id: Q5TZ66
db: uniprot

P01082
type: UnificationXref
id: P01082
db: PANTHER Pathway Component

P01084
type: UnificationXref
id: P01084
db: PANTHER Pathway Component

PTHR11559:SF397
type: RelationshipXref
id: PTHR11559:SF397
db: PANTHER Family
relationship type: By Homology

P01083
type: UnificationXref
id: P01083
db: PANTHER Pathway Component

Protein kinase A catalytic subunit
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q388U5 97
organism: Trypanosoma brucei

P01080
type: UnificationXref
id: P01080
db: PANTHER Pathway Component

uniprot Q6PH57 539
type: UnificationXref
id: Q6PH57
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CXD0 428
organism: Monodelphis domestica

uniprot H2QXB9 43
type: UnificationXref
id: H2QXB9
db: uniprot

PTHR24353:SF73
type: RelationshipXref
id: PTHR24353:SF73
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(t) subunit alpha-1
type: ProteinReference
xref: uniprot P04695 458
xref: PTHR10218:SF67
organism: Bos taurus

uniprot P48549 343
type: UnificationXref
id: P48549
db: uniprot

Protein kinase cAMP-activated catalytic subunit alpha
type: ProteinReference
xref: uniprot H2QFK0 41
xref: PTHR24353:SF82
organism: Pan troglodytes

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot F6VM87 183
organism: Monodelphis domestica

Putative syntaxin-4
type: ProteinReference
xref: uniprot P91409 241
organism: Caenorhabditis elegans

uniprot Q80SZ7 551
type: UnificationXref
id: Q80SZ7
db: uniprot

uniprot P36600 86
type: UnificationXref
id: P36600
db: uniprot

Guanine nucleotide-binding protein G(t) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF68
xref: uniprot P04696 459
organism: Bos taurus

uniprot P49177 484
type: UnificationXref
id: P49177
db: uniprot

uniprot P16520 469
type: UnificationXref
id: P16520
db: uniprot

uniprot Q9HAV0 557
type: UnificationXref
id: Q9HAV0
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 110

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 402
organism: Bos taurus

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot H2RER5 46
organism: Pan troglodytes

uniprot F7ES96 432
type: UnificationXref
id: F7ES96
db: uniprot

uniprot Q7ZUC1 267
type: UnificationXref
id: Q7ZUC1
db: uniprot

ncbitaxon 13616 31
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot H2QUQ1 200
type: UnificationXref
id: H2QUQ1
db: uniprot

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot Q9U295 315
organism: Caenorhabditis elegans

Choline O-acetyltransferase
type: ProteinReference
xref: uniprot P32738 133
xref: PTHR22589:SF14
organism: Rattus norvegicus

uniprot Q9DBC7 121
type: UnificationXref
id: Q9DBC7
db: uniprot

uniprot Q5E9F0 526
type: UnificationXref
id: Q5E9F0
db: uniprot

PTHR24353:SF67
type: RelationshipXref
id: PTHR24353:SF67
db: PANTHER Family
relationship type: By Homology

Synaptosomal-associated protein 23
type: ProteinReference
xref: uniprot O09044 205
xref: PTHR19305:SF4
organism: Mus musculus

uniprot A0A1D5QEM1 159
type: UnificationXref
id: A0A1D5QEM1
db: uniprot

AC
type: Protein
entity reference: AC
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=PROTEIN

GTP s1 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7BB02 425
organism: Macaca mulatta

ncbitaxon 7165 110
type: UnificationXref
id: 7165
db: ncbitaxon

Syntaxin-11
type: ProteinReference
xref: PTHR19957:SF30
xref: uniprot Q9D3G5 274
organism: Mus musculus

AC
type: ProteinReference
xref: P01082
standard name: adenylate cyclase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 2 and 4 signaling pathway.PROTEIN.GENERIC.AC
comment: ENTITY_REFERENCE_NOTES= Long Name: Adenylate Cyclase Synonym: AC Accession: P01082
member entity reference: Adenylate cyclase type 10
member entity reference: Uncharacterized protein
member entity reference: Guanylyl cyclase
member entity reference: Adenylate/guanylate cyclase

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 550
organism: Danio rerio

uniprot E2RIA0 325
type: UnificationXref
id: E2RIA0
db: uniprot

Vesicular acetylcholine transporter
type: ProteinReference
xref: uniprot Q16572 153
organism: Homo sapiens

uniprot E2RAJ0 352
type: UnificationXref
id: E2RAJ0
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot A8X8S6 167
organism: Caenorhabditis briggsae

uniprot A4IGZ2 374
type: UnificationXref
id: A4IGZ2
db: uniprot

Potassium voltage-gated channel subfamily J member 5
type: ProteinReference
xref: PTHR11767:SF52
xref: uniprot E2RPY4 326
organism: Canis lupus familiaris

TRANSPORT_LEFT__ACh-RIGHT__ACh-_r81
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 592
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 593
left: ACh
interaction type: TRANSPORT
right: ACh

Muscarinic acetylcholine receptor M4
type: ProteinReference
xref: uniprot P17200 143
xref: PTHR24248:SF142
organism: Gallus gallus

G protein-activated inward rectifier potassium channel 3
type: ProteinReference
xref: uniprot Q92806 349
xref: PTHR11767:SF17
organism: Homo sapiens

Cholinesterase
type: ProteinReference
xref: PTHR43918:SF5
xref: uniprot P32749 309
organism: Bos taurus

uniprot P48543 340
type: UnificationXref
id: P48543
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q63666 262
organism: Rattus norvegicus

heart muscle or neuron cytosol, or nerve terminal c2
type: CellularLocationVocabulary
comment: heart muscle or neuron cytosol, or nerve terminal

uniprot P16912 74
type: UnificationXref
id: P16912
db: uniprot

uniprot P32749 309
type: UnificationXref
id: P32749
db: uniprot

uniprot P62881 505
type: UnificationXref
id: P62881
db: uniprot

uniprot E2R4I7 392
type: UnificationXref
id: E2R4I7
db: uniprot

SNARE COMPLEX
type: ProteinReference
xref: P01079
standard name: N-ethylmaleimide-sensitive factor attachment protein receptor
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 2 and 4 signaling pathway.PROTEIN.GENERIC.SNARE COMPLEX
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: N-ethylmaleimide-sensitive factor attachment protein receptor Synonym: SNARE Accession: P01079
member entity reference: Syntaxin-124
member entity reference: Vesicle-associated membrane protein 3
member entity reference: Vesicle-associated membrane protein 2
member entity reference: Vesicle-associated membrane protein 8
member entity reference: Synaptosomal-associated protein 25
member entity reference: Syntaxin 3A
member entity reference: Synaptosomal-associated protein
member entity reference: Synaptobrevin homolog 1
member entity reference: Synaptosomal-associated protein 23
member entity reference: Syntaxin 16
member entity reference: Neuronal synaptobrevin, isoform J
member entity reference: Uncharacterized protein
member entity reference: Vesicle-associated membrane protein 1
member entity reference: Syntaxin-1A homolog
member entity reference: Syntaxin-19
member entity reference: Syntaxin-like protein 1
member entity reference: Protein SSO2
member entity reference: VAMP2 isoform 3
member entity reference: Syntaxin-1A
member entity reference: Syntaxin-3-like
member entity reference: Syntaxin-3
member entity reference: Syntaxin-123
member entity reference: STX11 isoform 1
member entity reference: Protein SSO1
member entity reference: Syntaxin 1B
member entity reference: LD03592p
member entity reference: Syntaxin-like protein psy1
member entity reference: Synaptosomal-associated protein 29
member entity reference: Syntaxin, Qa-SNARE family
member entity reference: Synaptobrevin
member entity reference: Putative synaptobrevin homologue SNC1/2 (Eurofung)
member entity reference: Putative syntaxin-131
member entity reference: VAMP3 isoform 1
member entity reference: Putative syntaxin-4
member entity reference: Syntaxin-16
member entity reference: Syntaxin 4
member entity reference: Protein CBR-SYX-2
member entity reference: Putative syntaxin-2
member entity reference: Vesicle associated membrane protein 8
member entity reference: Putative syntaxin-3
member entity reference: Syntaxin-11
member entity reference: Syntaxin-132
member entity reference: t-SNARE protein aex-4
member entity reference: Syntaxin-41
member entity reference: Syntaxin-4
member entity reference: Syntaxin family protein

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3KRE3 522
organism: Rattus norvegicus

High affinity choline transporter 1
type: ProteinReference
xref: uniprot Q8BGY9 363
organism: Mus musculus

G protein subunit beta 5
type: ProteinReference
xref: uniprot E2RHY4 396
organism: Canis lupus familiaris

uniprot A5PKD6 375
type: UnificationXref
id: A5PKD6
db: uniprot

uniprot Q5ASG1 258
type: UnificationXref
id: Q5ASG1
db: uniprot

High affinity choline transporter
type: ProteinReference
xref: uniprot Q7UFM6 361
organism: Rhodopirellula baltica

uniprot H2QMZ0 198
type: UnificationXref
id: H2QMZ0
db: uniprot

uniprot H2PZL0 445
type: UnificationXref
id: H2PZL0
db: uniprot

Syntaxin-4
type: ProteinReference
xref: uniprot Q7KVY7 266
organism: Drosophila melanogaster

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot O60262 457
organism: Homo sapiens

uniprot H2PZA6 443
type: UnificationXref
id: H2PZA6
db: uniprot

Choline O-acetyltransferase
type: ProteinReference
xref: uniprot P32756 134
xref: PTHR22589:SF14
organism: Caenorhabditis elegans

PTHR24353:SF82
type: RelationshipXref
id: PTHR24353:SF82
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
type: ProteinReference
xref: uniprot Q3ZCA7 524
organism: Bos taurus

uniprot Q8R1Q0 270
type: UnificationXref
id: Q8R1Q0
db: uniprot

uniprot A0A3Q1LYB4 163
type: UnificationXref
id: A0A3Q1LYB4
db: uniprot

uniprot Q8VBW1 364
type: UnificationXref
id: Q8VBW1
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot D3ZLD6 385
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5PCI4 8
xref: PTHR11635:SF126
organism: Gallus gallus

uniprot Q5ZJ03 529
type: UnificationXref
id: Q5ZJ03
db: uniprot

uniprot P21137 76
type: UnificationXref
id: P21137
db: uniprot

PTHR24353:SF37
type: RelationshipXref
id: PTHR24353:SF37
db: PANTHER Family
relationship type: By Homology

PTHR19305:SF5
type: RelationshipXref
id: PTHR19305:SF5
db: PANTHER Family
relationship type: By Homology

K+
type: SmallMolecule
comment: SPECIES_TYPE=ION

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 87

PKA
type: Protein
entity reference: PKA
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=PROTEIN

PTHR19305:SF9
type: RelationshipXref
id: PTHR19305:SF9
db: PANTHER Family
relationship type: By Homology

SYntaXin
type: ProteinReference
xref: uniprot Q9TY08 283
organism: Caenorhabditis elegans

uniprot O02228 355
type: UnificationXref
id: O02228
db: uniprot

uniprot G5EDN1 302
type: UnificationXref
id: G5EDN1
db: uniprot

Syntaxin-1A homolog
type: ProteinReference
xref: uniprot O16000 207
organism: Caenorhabditis elegans

uniprot Q9DDE3 313
type: UnificationXref
id: Q9DDE3
db: uniprot

uniprot A0NDL1 149
type: UnificationXref
id: A0NDL1
db: uniprot

ncbitaxon 9598 42
type: UnificationXref
id: 9598
db: ncbitaxon

DISSOCIATION_LEFT__Complex__CHT1_choline_-RIGHT__choline-_CHT1-_r80
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 597
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 598
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 599
left: Complex (CHT1/choline)
interaction type: DISSOCIATION
right: choline
right: CHT1

uniprot A0A1D5QIS2 160
type: UnificationXref
id: A0A1D5QIS2
db: uniprot

PTHR19305:SF4
type: RelationshipXref
id: PTHR19305:SF4
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF162
type: RelationshipXref
id: PTHR11635:SF162
db: PANTHER Family
relationship type: By Homology

SNARE COMPLEX
type: Protein
entity reference: SNARE COMPLEX
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot P06276 305
type: UnificationXref
id: P06276
db: uniprot

DISSOCIATION
type: InteractionVocabulary

uniprot P18872 472
type: UnificationXref
id: P18872
db: uniprot

Potassium voltage-gated channel subfamily J member 6
type: ProteinReference
xref: PTHR11767:SF19
xref: uniprot E2RIA0 325
organism: Canis lupus familiaris

AGAP011840-PA (Fragment)
type: ProteinReference
xref: uniprot Q7PZC6 112
xref: PTHR24353:SF37
organism: Anopheles gambiae

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q0VFC4 516
organism: Xenopus tropicalis

uniprot H2QFK0 41
type: UnificationXref
id: H2QFK0
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6TH03 540
organism: Danio rerio

uniprot P12370 69
type: UnificationXref
id: P12370
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR16305:SF28
xref: uniprot F7D9M6 316
organism: Macaca mulatta

uniprot P30372 144
type: UnificationXref
id: P30372
db: uniprot

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot Q20636 519
organism: Caenorhabditis elegans

uniprot F7CFG8 426
type: UnificationXref
id: F7CFG8
db: uniprot

GDP
type: SmallMolecule
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot E9AFM1 20
type: UnificationXref
id: E9AFM1
db: uniprot

G protein-activated inward rectifier potassium channel 4
type: ProteinReference
xref: PTHR11767:SF52
xref: uniprot F1MYR9 328
organism: Bos taurus

By Homology
type: RelationshipTypeVocabulary

GNB4 protein
type: ProteinReference
xref: uniprot A5PKD6 375
organism: Bos taurus

uniprot Q16572 153
type: UnificationXref
id: Q16572
db: uniprot

GO GO:0043679 3
type: UnificationXref
id: GO:0043679
db: GO

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 64

STATE_TRANSITION_LEFT__AC-RIGHT__AC-_r44
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 608
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 609
left: AC
interaction type: STATE_TRANSITION
right: AC

uniprot P06245 61
type: UnificationXref
id: P06245
db: uniprot

PTHR11635:SF157
type: RelationshipXref
id: PTHR11635:SF157
db: PANTHER Family
relationship type: By Homology

uniprot P61265 231
type: UnificationXref
id: P61265
db: uniprot

uniprot H2QMN4 449
type: UnificationXref
id: H2QMN4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot F7FD32 434
organism: Macaca mulatta

PTHR11635:SF156
type: RelationshipXref
id: PTHR11635:SF156
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF153
type: RelationshipXref
id: PTHR11635:SF153
db: PANTHER Family
relationship type: By Homology

uniprot Q7T3D3 548
type: UnificationXref
id: Q7T3D3
db: uniprot

uniprot F6UFJ7 181
type: UnificationXref
id: F6UFJ7
db: uniprot

PKA
type: Protein
entity reference: PKA
feature: ACTIVE 123
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=PROTEIN

PTHR11635:SF152
type: RelationshipXref
id: PTHR11635:SF152
db: PANTHER Family
relationship type: By Homology

uniprot Q5R1X1 259
type: UnificationXref
id: Q5R1X1
db: uniprot

uniprot P31324 84
type: UnificationXref
id: P31324
db: uniprot

uniprot Q6P025 535
type: UnificationXref
id: Q6P025
db: uniprot

uniprot P36408 480
type: UnificationXref
id: P36408
db: uniprot

PTHR11635:SF159
type: RelationshipXref
id: PTHR11635:SF159
db: PANTHER Family
relationship type: By Homology

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q28HP6 255
organism: Xenopus tropicalis

ATP
type: SmallMolecule
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Syntaxin 2
type: ProteinReference
xref: uniprot Q1K7J3 251
organism: Neurospora crassa

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
type: ProteinReference
xref: uniprot Q7ZW82 549
xref: PTHR10218:SF227
organism: Danio rerio

cAMP-dependent protein kinase catalytic subunit alpha isoform 1
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H9EQQ4 48
organism: Macaca mulatta

Muscarinic acetylcholine receptor
type: ProteinReference
xref: PTHR24247:SF180
xref: uniprot F1PVZ1 137
organism: Canis lupus familiaris

uniprot P63097 509
type: UnificationXref
id: P63097
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot F7HAK5 38
organism: Macaca mulatta

Syntaxin-123
type: ProteinReference
xref: uniprot Q9ZQZ8 290
organism: Arabidopsis thaliana

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__ACh-RIGHT__Acetyl_CoA-_choline-_r59
controller: AChE

uniprot F5HH30 407
type: UnificationXref
id: F5HH30
db: uniprot

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 209

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P22694 79
xref: PTHR24353:SF116
organism: Homo sapiens

Syntaxin-3-like
type: ProteinReference
xref: uniprot D3ZUH2 168
organism: Rattus norvegicus

uniprot P62871 499
type: UnificationXref
id: P62871
db: uniprot

STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_r69
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 612
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 613
left: Ca2+ channel
interaction type: STATE_TRANSITION
right: Ca2+ channel

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E1C795 389
organism: Gallus gallus

uniprot Q6PBR4 537
type: UnificationXref
id: Q6PBR4
db: uniprot

PRKAR2A isoform 1
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot K7AEL3 49
organism: Pan troglodytes

uniprot Q9Z2P6 289
type: UnificationXref
id: Q9Z2P6
db: uniprot

uniprot E2RU39 175
type: UnificationXref
id: E2RU39
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot R4GKD1 560
organism: Gallus gallus

mAChR2 4 s7 sa6 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.4633432079864352
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

AGAP010589-PA
type: ProteinReference
xref: uniprot Q7Q8S4 547
organism: Anopheles gambiae

Carboxylic ester hydrolase
type: ProteinReference
xref: PTHR11559:SF397
xref: uniprot C3ZD75 297
organism: Branchiostoma floridae

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 432
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NLV4 403
organism: Gallus gallus

uniprot F7FXA9 435
type: UnificationXref
id: F7FXA9
db: uniprot

uniprot O76689 356
type: UnificationXref
id: O76689
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V8K2 442
organism: Rattus norvegicus

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot P31109 220
organism: Saccharomyces cerevisiae

DISSOCIATION_LEFT__Complex__GDP_G_Protein__mAChR2_4_-_ACh-_GTP-RIGHT__Complex__GTP_G_Protein_-_GDP-_Complex__mAChR2_4__ACh_-_r53
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 587
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 589
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 590
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 586
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 588
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 591
left: Complex (GDP/G-Protein/ mAChR2/4)
left: GTP
left: ACh
interaction type: DISSOCIATION
right: Complex (mAChR2/4/ ACh)
right: Complex (GTP/G-Protein)
right: GDP

AGAP001384-PA
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot Q7PXF7 111
organism: Anopheles gambiae

uniprot O09044 205
type: UnificationXref
id: O09044
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: muscle contraction
controller: Ca2+

PTHR10218:SF73
type: RelationshipXref
id: PTHR10218:SF73
db: PANTHER Family
relationship type: By Homology

uniprot P09471 465
type: UnificationXref
id: P09471
db: uniprot

uniprot Q20024 252
type: UnificationXref
id: Q20024
db: uniprot

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot A7EDU2 376
organism: Sclerotinia sclerotiorum

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot P54406 494
organism: Caenorhabditis elegans

uniprot B7Q3T6 381
type: UnificationXref
id: B7Q3T6
db: uniprot

uniprot A8XJQ6 12
type: UnificationXref
id: A8XJQ6
db: uniprot

cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B
type: ProteinReference
xref: PTHR11635:SF159
xref: uniprot Q8MM62 119
organism: Dictyostelium discoideum

uniprot A8X8S6 167
type: UnificationXref
id: A8X8S6
db: uniprot

Syntaxin-132
type: ProteinReference
xref: uniprot Q8VZU2 271
organism: Arabidopsis thaliana

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: PTHR11767:SF16
xref: uniprot P48549 343
organism: Homo sapiens

choline s12 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: choline
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot Q17499 136
organism: Caenorhabditis elegans

G protein-activated inward rectifier potassium channel 4
type: ProteinReference
xref: PTHR11767:SF52
xref: uniprot P48545 342
organism: Mus musculus

SNAP29 isoform 1
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot H2QLA1 197
organism: Pan troglodytes

G protein subunit alpha transducin 1
type: ProteinReference
xref: uniprot A0A2J8P954 371
xref: PTHR10218:SF67
organism: Pan troglodytes

G protein-activated inward rectifier potassium channel 4
type: ProteinReference
xref: PTHR11767:SF52
xref: uniprot P48544 341
organism: Homo sapiens

G protein-activated inward rectifier potassium channel 3
type: ProteinReference
xref: uniprot P48543 340
xref: PTHR11767:SF17
organism: Mus musculus

G protein subunit alpha i3
type: ProteinReference
xref: uniprot Q5I080 527
organism: Xenopus tropicalis

G protein-activated inward rectifier potassium channel 2
type: ProteinReference
xref: uniprot P48542 339
xref: PTHR11767:SF19
organism: Mus musculus

uniprot Q9CXP8 555
type: UnificationXref
id: Q9CXP8
db: uniprot

ncbitaxon 6669 24
type: UnificationXref
id: 6669
db: ncbitaxon

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 59

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F2Z3T8 406
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P36600 86
organism: Schizosaccharomyces pombe

uniprot F6R7N8 30
type: UnificationXref
id: F6R7N8
db: uniprot

uniprot P12368 66
type: UnificationXref
id: P12368
db: uniprot

uniprot G2HIJ9 194
type: UnificationXref
id: G2HIJ9
db: uniprot

uniprot Q7Q6D2 543
type: UnificationXref
id: Q7Q6D2
db: uniprot

PTHR10218:SF68
type: RelationshipXref
id: PTHR10218:SF68
db: PANTHER Family
relationship type: By Homology

PTHR10218:SF67
type: RelationshipXref
id: PTHR10218:SF67
db: PANTHER Family
relationship type: By Homology

ACTIVE 123
type: EntityFeature
comment: Active state

PTHR11635:SF129
type: RelationshipXref
id: PTHR11635:SF129
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF126
type: RelationshipXref
id: PTHR11635:SF126
db: PANTHER Family
relationship type: By Homology

uniprot P00514 50
type: UnificationXref
id: P00514
db: uniprot

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 98

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 22

PARTICIPANT STOICHIOMETRY r59 622
type: Stoichiometry
physical entity: choline
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot P61954 498
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7E376 454
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r59 621
type: Stoichiometry
physical entity: Acetyl CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 620
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot P61952 496
organism: Homo sapiens

uniprot F7H6T2 37
type: UnificationXref
id: F7H6T2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 551
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot P61953 497
organism: Mus musculus

uniprot Q7QFG0 312
type: UnificationXref
id: Q7QFG0
db: uniprot

ncbitaxon 10116 67
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot P43425 483
type: UnificationXref
id: P43425
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q90Z40 554
organism: Danio rerio

ncbitaxon 184922 19
type: UnificationXref
id: 184922
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r70 617
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r70 616
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

CHT1
type: Protein
entity reference: CHT1
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa10 581
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa5 571
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__VAChT-_ACh-RIGHT__Complex__VAChT_ACh_-_r77
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 604
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 605
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 603
left: ACh
left: VAChT
interaction type: HETERODIMER_ASSOCIATION
right: Complex (VAChT/ACh)

Acetylcholinesterase
type: ProteinReference
xref: uniprot P23795 308
organism: Bos taurus

uniprot P60879 228
type: UnificationXref
id: P60879
db: uniprot

G-Protein
type: ProteinReference
xref: P01085
standard name: Gi-protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Muscarinic acetylcholine receptor 2 and 4 signaling pathway.PROTEIN.GENERIC.G-Protein
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Guanine nucleotide binding protein, beta subunit
member entity reference: G protein subunit beta 4
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
member entity reference: Guanine nucleotide-binding protein subunit beta-4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: Gnb1l protein
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: THO complex subunit, putative
member entity reference: Guanine nucleotide-binding protein G(t) subunit alpha-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
member entity reference: G protein subunit alpha i1
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1
member entity reference: Guanine nucleotide binding protein, beta 3
member entity reference: AGAP010589-PA
member entity reference: Guanine nucleotide-binding protein subunit beta-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
member entity reference: G protein subunit alpha transducin 2
member entity reference: Gbeta5
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
member entity reference: G protein alpha o subunit
member entity reference: AGAP005913-PA
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
member entity reference: G protein subunit alpha i3
member entity reference: Guanine nucleotide-binding protein G(o) subunit alpha
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
member entity reference: G protein subunit beta 1
member entity reference: AGAP005912-PA
member entity reference: G protein alpha i subunit
member entity reference: Guanine nucleotide-binding protein G(O) subunit alpha 1
member entity reference: Guanine nucleotide-binding protein G(t) subunit alpha-1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: G protein subunit beta 5
member entity reference: Guanine nucleotide-binding protein subunit beta-5b
member entity reference: Guanine nucleotide-binding protein subunit gamma-1

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 423
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r44 609
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

uniprot A0A2J8Q8V8 294
type: UnificationXref
id: A0A2J8Q8V8
db: uniprot

uniprot Q5XGD8 528
type: UnificationXref
id: Q5XGD8
db: uniprot

uniprot M9PE71 202
type: UnificationXref
id: M9PE71
db: uniprot

uniprot P63025 234
type: UnificationXref
id: P63025
db: uniprot

uniprot F6W0P2 416
type: UnificationXref
id: F6W0P2
db: uniprot

uniprot Q7T374 114
type: UnificationXref
id: Q7T374
db: uniprot

t-SNARE protein aex-4
type: ProteinReference
xref: uniprot G5EEN8 195
organism: Caenorhabditis elegans

uniprot Q17QQ3 250
type: UnificationXref
id: Q17QQ3
db: uniprot

uniprot O16000 207
type: UnificationXref
id: O16000
db: uniprot

PARTICIPANT STOICHIOMETRY r44 608
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

uniprot Q9SWH4 282
type: UnificationXref
id: Q9SWH4
db: uniprot

Protein kinase A catalytic subunit isoform 2
type: ProteinReference
xref: PTHR24353:SF67
xref: uniprot E9AFM1 20
organism: Leishmania major

PANTHER Pathway P00043 1
type: UnificationXref
id: P00043
db: PANTHER Pathway

uniprot A0A0D1DSN6 4
type: UnificationXref
id: A0A0D1DSN6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot O16992 130
organism: Caenorhabditis elegans

uniprot A0A2I3TUD1 370
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

CAT
type: Protein
entity reference: CAT
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

K+
type: SmallMolecule
cellular location: heart muscle or neuron cytosol, or nerve terminal c2
comment: SPECIES_TYPE=ION

uniprot H2Q995 196
type: UnificationXref
id: H2Q995
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot P23763 219
organism: Homo sapiens

uniprot P30671 479
type: UnificationXref
id: P30671
db: uniprot

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 362

G protein subunit beta 3
type: ProteinReference
xref: uniprot H2R3A6 452
organism: Pan troglodytes

Complex (GDP/G-Protein/ mAChR2/4)
type: Complex
component stoichiometry: GDP s3 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s5 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: mAChR2 4 s6 sa3 STOICHIOMETRY ID COMPLEX
component: G-Protein
component: mAChR2/4
component: GDP
feature: COMPLEX BINDING FEATURE s58 a64 562
feature: COMPLEX BINDING FEATURE s58 a64 564
feature: COMPLEX BINDING FEATURE s58 a64 566
cellular location: heart muscle or neuron cytosol, or nerve terminal c2

uniprot W4Y9B6 293
type: UnificationXref
id: W4Y9B6
db: uniprot

CHAT isoform 7
type: ProteinReference
xref: uniprot H2RAF8 129
xref: PTHR22589:SF14
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR11767:SF52
xref: uniprot F7EPF6 335
organism: Macaca mulatta

uniprot Q803H5 550
type: UnificationXref
id: Q803H5
db: uniprot

uniprot F1MYW8 402
type: UnificationXref
id: F1MYW8
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_r67
controller: AC

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: uniprot F7A472 424
xref: PTHR10218:SF227
organism: Xenopus tropicalis

uniprot D3ZSS5 386
type: UnificationXref
id: D3ZSS5
db: uniprot

uniprot Q24547 254
type: UnificationXref
id: Q24547
db: uniprot

uniprot P59215 495
type: UnificationXref
id: P59215
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

uniprot Q7JP68 108
type: UnificationXref
id: Q7JP68
db: uniprot

cAMP-dependent protein kinase, catalytic subunit-like
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot A8XJQ6 12
organism: Caenorhabditis briggsae

TRANSPORT
type: InteractionVocabulary

ACh s10 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

uniprot H2QTV4 199
type: UnificationXref
id: H2QTV4
db: uniprot

uniprot Q9BV40 273
type: UnificationXref
id: Q9BV40
db: uniprot

G protein subunit alpha transducin 2
type: ProteinReference
xref: PTHR10218:SF68
xref: uniprot E2R4I7 392
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot F7G4Q0 36
organism: Monodelphis domestica

PTHR11767:SF52
type: RelationshipXref
id: PTHR11767:SF52
db: PANTHER Family
relationship type: By Homology

PRKACG isoform 1
type: ProteinReference
xref: PTHR24353:SF137
xref: uniprot H2QXB9 43
organism: Pan troglodytes

Potassium voltage-gated channel subfamily J member 6
type: ProteinReference
xref: PTHR11767:SF19
xref: uniprot F6WIC7 332
organism: Ornithorhynchus anatinus

uniprot Q00262 242
type: UnificationXref
id: Q00262
db: uniprot

uniprot Q8BVI5 268
type: UnificationXref
id: Q8BVI5
db: uniprot

uniprot P04696 459
type: UnificationXref
id: P04696
db: uniprot

uniprot Q9D3G5 274
type: UnificationXref
id: Q9D3G5
db: uniprot

Carboxylic ester hydrolase
type: ProteinReference
xref: uniprot Q9JKC1 314
organism: Rattus norvegicus

uniprot F7EP58 192
type: UnificationXref
id: F7EP58
db: uniprot

High affinity choline transporter 1
type: ProteinReference
xref: uniprot Q9JMD7 366
organism: Rattus norvegicus

uniprot Q9VR90 286
type: UnificationXref
id: Q9VR90
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 21

Acetyl CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F1PVP1 177
type: UnificationXref
id: F1PVP1
db: uniprot

uniprot Q3KRE3 522
type: UnificationXref
id: Q3KRE3
db: uniprot

uniprot Q9SVC2 281
type: UnificationXref
id: Q9SVC2
db: uniprot

ncbitaxon 367110 94
type: UnificationXref
id: 367110
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UST7 331
xref: PTHR11767:SF17
organism: Monodelphis domestica

PTHR11767:SF16
type: RelationshipXref
id: PTHR11767:SF16
db: PANTHER Family
relationship type: By Homology

uniprot Q9SRV7 280
type: UnificationXref
id: Q9SRV7
db: uniprot

PTHR11767:SF17
type: RelationshipXref
id: PTHR11767:SF17
db: PANTHER Family
relationship type: By Homology

PTHR11767:SF19
type: RelationshipXref
id: PTHR11767:SF19
db: PANTHER Family
relationship type: By Homology

uniprot F7HAK5 38
type: UnificationXref
id: F7HAK5
db: uniprot

Uncharacterized MFS-type transporter C18.02
type: ProteinReference
xref: uniprot O74852 152
xref: PTHR23506:SF23
organism: Schizosaccharomyces pombe

uniprot E2RBE7 394
type: UnificationXref
id: E2RBE7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ES15 193
organism: Ornithorhynchus anatinus

choline
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Syntaxin 3A
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot Q6PHV0 265
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ERP8 431
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r68 614
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r68 615
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

uniprot Q28H40 521
type: UnificationXref
id: Q28H40
db: uniprot

uniprot P16378 468
type: UnificationXref
id: P16378
db: uniprot

uniprot F7ERG6 336
type: UnificationXref
id: F7ERG6
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P36408 480
organism: Dictyostelium discoideum

uniprot Q7PPI8 109
type: UnificationXref
id: Q7PPI8
db: uniprot

uniprot P62872 500
type: UnificationXref
id: P62872
db: uniprot

uniprot F1P393 126
type: UnificationXref
id: F1P393
db: uniprot

uniprot Q6PC54 264
type: UnificationXref
id: Q6PC54
db: uniprot

cGMP-dependent 3',5'-cGMP phosphodiesterase A
type: ProteinReference
xref: PTHR11635:SF157
xref: uniprot Q8MLZ3 118
organism: Dictyostelium discoideum

cAMP-dependent protein kinase catalytic subunit TPK2
type: ProteinReference
xref: uniprot A0A0D1DSN6 4
xref: PTHR24353:SF117
organism: Ustilago maydis

uniprot E1C795 389
type: UnificationXref
id: E1C795
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta isoform 1
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot F7EBQ5 35
organism: Macaca mulatta

uniprot F6UJE8 412
type: UnificationXref
id: F6UJE8
db: uniprot

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: uniprot Q90854 348
xref: PTHR11767:SF16
organism: Gallus gallus

uniprot P50146 485
type: UnificationXref
id: P50146
db: uniprot

G protein-activated inward rectifier potassium channel 2
type: ProteinReference
xref: PTHR11767:SF19
xref: uniprot P48550 344
organism: Rattus norvegicus