uniprot Q13936 90
type: UnificationXref
id: Q13936
db: uniprot

uniprot O43497 88
type: UnificationXref
id: O43497
db: uniprot

CHRNB3 s139 sa114 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNB3
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: depolarization
controller: KCNK3/9

uniprot Q5SUF7 91
type: UnificationXref
id: Q5SUF7
db: uniprot

Dopamine s158 sa106 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Protein 4.1
type: ProteinReference
xref: PTHR23280:SF12
xref: uniprot P11171 146
organism: Homo sapiens

uniprot Q60829 25
type: UnificationXref
id: Q60829
db: uniprot

Neuronal acetylcholine receptor subunit alpha-3
type: ProteinReference
xref: uniprot Q8R4G9 67
xref: PTHR18945:SF831
organism: Mus musculus

ncbitaxon 13616 8
type: UnificationXref
id: 13616
db: ncbitaxon

Potassium channel subfamily K member 9
type: ProteinReference
xref: uniprot Q9NPC2 139
xref: PTHR11003:SF75
organism: Homo sapiens

CHRNB4 s164 sa108 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNB4
stoichiometric coefficient: 3.0

PTHR24248:SF87
type: RelationshipXref
id: PTHR24248:SF87
db: PANTHER Family
relationship type: By Homology

CHRNA5 s256 sa126 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA5
stoichiometric coefficient: 1.0

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot Q08462 142
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63212 33
xref: PTHR13809:SF25
organism: Bos taurus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 16

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Na_PLUS_-RIGHT__Na_PLUS_-_re36
control type: ACTIVATION
controller: CHRNA4/CHRNB2 complex

Filamin-A
type: ProteinReference
xref: PTHR38537:SF5
xref: uniprot Q8BTM8 97
organism: Mus musculus

Protein 4.1
type: ProteinReference
xref: PTHR23280:SF12
xref: uniprot P48193 147
organism: Mus musculus

CHRNA6 s135 sa113 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA6
stoichiometric coefficient: 1.0

CHRNA3
type: Protein
entity reference: CHRNA3

uniprot P14173 151
type: UnificationXref
id: P14173
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P17612 18
xref: PTHR24353:SF82
organism: Homo sapiens

KCNK3 9 s227 sa53 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.92
comment: MODIFICATION_RESIDUE_NAME=

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot P62874 44
organism: Mus musculus

uniprot F1PN73 172
type: UnificationXref
id: F1PN73
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot P62872 42
organism: Canis lupus familiaris

EPB41
type: Protein
entity reference: EPB41
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 43
xref: PTHR19850:SF29
organism: Homo sapiens

Erythrocyte membrane protein band 4.1 like 1
type: ProteinReference
xref: uniprot A0A2I3RMK9 78
xref: PTHR23280:SF24
organism: Pan troglodytes

uniprot P62136 107
type: UnificationXref
id: P62136
db: uniprot

CHRNA4 s173 sa102 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA4
stoichiometric coefficient: 1.0

DRD2 DRD3 DRD4 s196 sa79 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DRD2/ DRD3/ DRD4
stoichiometric coefficient: 1.0

Neuronal acetylcholine receptor subunit beta-3
type: ProteinReference
xref: PTHR18945:SF75
xref: uniprot Q05901 174
organism: Homo sapiens

Neuronal acetylcholine receptor subunit beta-2
type: ProteinReference
xref: uniprot Q9ERK7 183
xref: PTHR18945:SF80
organism: Mus musculus

CHRNA3
type: ProteinReference
xref: P06595
standard name: Nicotinic acetylcholine receptor alpha 3 subunit
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.RECEPTOR.CHRNA3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Neuronal acetylcholine receptor subunit alpha-3
member entity reference: Uncharacterized protein

CHRNA4/CHRNB2/CHRNA5 complex
type: Complex
component stoichiometry: CHRNA4 s254 sa124 STOICHIOMETRY ID COMPLEX
component stoichiometry: CHRNA5 s256 sa126 STOICHIOMETRY ID COMPLEX
component: CHRNB2
component: CHRNA5
component: CHRNA4
feature: COMPLEX BINDING FEATURE s249 csa25 205
feature: COMPLEX BINDING FEATURE s249 csa25 203
feature: COMPLEX BINDING FEATURE s249 csa25 207
cellular location: cytosol

uniprot F7GCM2 95
type: UnificationXref
id: F7GCM2
db: uniprot

Neuronal acetylcholine receptor subunit alpha-5
type: ProteinReference
xref: PTHR18945:SF76
xref: uniprot Q2MKA5 55
organism: Mus musculus

Gnai3 protein
type: ProteinReference
xref: uniprot A9JTC8 154
xref: PTHR10218:SF230
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GMZ4 179
xref: PTHR18945:SF80
organism: Macaca mulatta

GNAI s220 sa66 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GNAI
stoichiometric coefficient: 1.0

uniprot O14649 136
type: UnificationXref
id: O14649
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 41
xref: PTHR19850:SF29
organism: Bos taurus

uniprot P11171 146
type: UnificationXref
id: P11171
db: uniprot

Dopa decarboxylase
type: ProteinReference
xref: uniprot A0A2I3TP36 148
xref: PTHR11999:SF70
organism: Pan troglodytes

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
type: ProteinReference
xref: PTHR11668:SF377
xref: uniprot P62136 107
organism: Homo sapiens

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
type: ProteinReference
xref: PTHR11668:SF377
xref: uniprot P62138 109
organism: Rattus norvegicus

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
type: ProteinReference
xref: PTHR11668:SF377
xref: uniprot P62137 108
organism: Mus musculus

DISSOCIATION_LEFT__SCL18A2_DOPA_complex-RIGHT__SLC18A2-_DOPA-_re24
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 332
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 330
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 331
left: SCL18A2/DOPA complex
interaction type: DISSOCIATION
right: DOPA
right: SLC18A2

GNB s210 sa67 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GNB
stoichiometric coefficient: 1.0

uniprot F7GWW5 85
type: UnificationXref
id: F7GWW5
db: uniprot

GNG
type: Protein
entity reference: GNG
feature: COMPLEX PARTICIPANT BINDING FEATURE s214 sa68 280
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5RHE7 140
type: UnificationXref
id: A0A1D5RHE7
db: uniprot

D(2) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF87
xref: uniprot P60026 123
organism: Pan troglodytes

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 12

CHRNA4 CHRNB2 complex s168 csa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA4/CHRNB2 complex
stoichiometric coefficient: 1.0

Na+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

PTHR18945:SF831
type: RelationshipXref
id: PTHR18945:SF831
db: PANTHER Family
relationship type: By Homology

uniprot F7A472 157
type: UnificationXref
id: F7A472
db: uniprot

P06589
type: UnificationXref
id: P06589
db: PANTHER Pathway Component

CHRNB3 s176 sa105 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNB3
stoichiometric coefficient: 1.0

P06588
type: UnificationXref
id: P06588
db: PANTHER Pathway Component

D(2) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF87
xref: uniprot P61168 124
organism: Mus musculus

D(2) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF87
xref: uniprot P61169 125
organism: Rattus norvegicus

Cholinergic receptor nicotinic beta 4 subunit
type: ProteinReference
xref: PTHR18945:SF385
xref: uniprot F1MC93 163
organism: Bos taurus

uniprot Q96NY7 170
type: UnificationXref
id: Q96NY7
db: uniprot

P06591
type: UnificationXref
id: P06591
db: PANTHER Pathway Component

P06590
type: UnificationXref
id: P06590
db: PANTHER Pathway Component

uniprot P00517 13
type: UnificationXref
id: P00517
db: uniprot

PARTICIPANT STOICHIOMETRY re24 330
type: Stoichiometry
physical entity: SCL18A2/DOPA complex
stoichiometric coefficient: 1.0

P06595
type: UnificationXref
id: P06595
db: PANTHER Pathway Component

P06594
type: UnificationXref
id: P06594
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re24 332
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

P06593
type: UnificationXref
id: P06593
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re24 331
type: Stoichiometry
physical entity: SLC18A2
stoichiometric coefficient: 1.0

P06592
type: UnificationXref
id: P06592
db: PANTHER Pathway Component

P06599
type: UnificationXref
id: P06599
db: PANTHER Pathway Component

P06598
type: UnificationXref
id: P06598
db: PANTHER Pathway Component

P06597
type: UnificationXref
id: P06597
db: PANTHER Pathway Component

P06596
type: UnificationXref
id: P06596
db: PANTHER Pathway Component

epinephrine
type: SmallMolecule
cellular location: bloodstream c3
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Neuronal acetylcholine receptor subunit beta-4
type: ProteinReference
xref: uniprot P30926 164
xref: PTHR18945:SF385
organism: Homo sapiens

uniprot Q8R4G9 67
type: UnificationXref
id: Q8R4G9
db: uniprot

DRD2/ DRD3/ DRD4
type: Protein
entity reference: DRD2/ DRD3/ DRD4
feature: COMPLEX PARTICIPANT BINDING FEATURE s194 sa75 298
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P61287 106
type: UnificationXref
id: P61287
db: uniprot

CHRNB4
type: Complex
component stoichiometry: CHRNB4 s164 sa108 STOICHIOMETRY ID COMPLEX
component: CHRNB4
feature: COMPLEX PARTICIPANT BINDING FEATURE s164 sa108 266

CHRNB4
type: Complex
component stoichiometry: CHRNB4 s8 sa12 STOICHIOMETRY ID COMPLEX
component: CHRNB4
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa12 274
cellular location: cytosol

HOMODIMER ID 69STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA3
stoichiometric coefficient: 2.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6QDH4 178
xref: PTHR18945:SF80
organism: Monodelphis domestica

CHRNA4 s254 sa124 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA4
stoichiometric coefficient: 1.0

PTHR24247:SF205
type: RelationshipXref
id: PTHR24247:SF205
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5QT69 127
type: UnificationXref
id: A0A1D5QT69
db: uniprot

GNAI
type: ProteinReference
xref: P06609
standard name: Guanine nuceotide-binding protein, alpha-inhibiting activity polypeptide
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.GNAI
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
member entity reference: Gnai3 protein
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1
member entity reference: G protein subunit alpha i1

HOMODIMER ID 68STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA3
stoichiometric coefficient: 2.0

DOPA
type: SmallMolecule
cellular location: synaptic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A0G2K161 144
type: UnificationXref
id: A0A0G2K161
db: uniprot

uniprot F1PWW0 94
type: UnificationXref
id: F1PWW0
db: uniprot

TRANSPORT_LEFT__Dopamine-RIGHT__Dopamine-_re17
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 363
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 364
left: Dopamine
interaction type: TRANSPORT
right: Dopamine

Synaptic vesicular amine transporter
type: ProteinReference
xref: PTHR23506:SF30
xref: uniprot Q05940 131
organism: Homo sapiens

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__CACNA-RIGHT__CACNA-_re6
control type: ACTIVATION
controller: depolarization

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 37
xref: PTHR19850:SF29
organism: Ornithorhynchus anatinus

Neuronal acetylcholine receptor subunit alpha-5
type: ProteinReference
xref: PTHR18945:SF76
xref: uniprot P30532 54
organism: Homo sapiens

uniprot P17787 182
type: UnificationXref
id: P17787
db: uniprot

Cholinergic receptor nicotinic alpha 5 subunit
type: ProteinReference
xref: PTHR18945:SF76
xref: uniprot F7GDB2 51
organism: Monodelphis domestica

SLC18A2 isoform 1
type: ProteinReference
xref: PTHR23506:SF30
xref: uniprot H2Q2M8 129
organism: Pan troglodytes

GNAI s218 sa59 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: uniprot F7FNW0 149
xref: PTHR11999:SF70
organism: Macaca mulatta

PANTHER Pathway P06587 1
type: UnificationXref
id: P06587
db: PANTHER Pathway

EPB41 s55 sa74 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EPB41
stoichiometric coefficient: 1.0

PTHR11668:SF300
type: RelationshipXref
id: PTHR11668:SF300
db: PANTHER Family
relationship type: By Homology

uniprot Q9NPC2 139
type: UnificationXref
id: Q9NPC2
db: uniprot

Potassium channel subfamily K member 3
type: ProteinReference
xref: uniprot O35111 137
xref: PTHR11003:SF138
organism: Mus musculus

KCNK3/9
type: Protein
entity reference: KCNK3/9
feature: ACTIVE 24
feature: KCNK3 9 s227 sa53 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re28 318
type: Stoichiometry
physical entity: DRD2/ DRD3/ DRD4
stoichiometric coefficient: 1.0

GNB s211 sa69 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GNB
stoichiometric coefficient: 1.0

Filamin-A
type: ProteinReference
xref: PTHR38537:SF5
xref: uniprot P21333 96
organism: Homo sapiens

CHRNB2
type: Complex
component stoichiometry: CHRNB2 s174 sa103 STOICHIOMETRY ID COMPLEX
component: CHRNB2
feature: COMPLEX PARTICIPANT BINDING FEATURE s174 sa103 254
cellular location: cytosol

Chloride intracellular channel protein
type: ProteinReference
xref: uniprot F6Q8V4 168
xref: PTHR45476:SF1
organism: Macaca mulatta

CHRNB2
type: Complex
component stoichiometry: CHRNB2 s255 sa125 STOICHIOMETRY ID COMPLEX
component: CHRNB2
feature: COMPLEX PARTICIPANT BINDING FEATURE s255 sa125 206
cellular location: cytosol

Serine/threonine-protein phosphatase (Fragment)
type: ProteinReference
xref: uniprot E9G7U7 102
xref: PTHR11668:SF472
organism: Daphnia pulex

CLIC6
type: Protein
entity reference: CLIC6
feature: COMPLEX PARTICIPANT BINDING FEATURE s50 sa72 226
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CHRNB2
type: Complex
component stoichiometry: CHRNB2 s262 sa122 STOICHIOMETRY ID COMPLEX
component: CHRNB2
feature: COMPLEX PARTICIPANT BINDING FEATURE s262 sa122 212

PARTICIPANT STOICHIOMETRY re28 319
type: Stoichiometry
physical entity: EPB41L2
stoichiometric coefficient: 1.0

CHRNB2
type: Complex
component stoichiometry: CHRNB2 s31 sa112 STOICHIOMETRY ID COMPLEX
component: CHRNB2
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa112 238

CHRNB2
type: Complex
component stoichiometry: CHRNB2 s167 sa91 STOICHIOMETRY ID COMPLEX
component: CHRNB2
feature: COMPLEX PARTICIPANT BINDING FEATURE s167 sa91 304
cellular location: cytosol

DRD2/DRD3/DRD4 EBP41 complex
type: Complex
component stoichiometry: EPB41 s55 sa74 STOICHIOMETRY ID COMPLEX
component stoichiometry: DRD2 DRD3 DRD4 s193 sa73 STOICHIOMETRY ID COMPLEX
component: EPB41
component: DRD2/ DRD3/ DRD4
feature: COMPLEX BINDING FEATURE s232 csa9 261
feature: COMPLEX BINDING FEATURE s232 csa9 259
cellular location: cytosol

CHRNB3
type: ProteinReference
xref: P06612
standard name: Nicotinic acetylcholine receptor beta 3 subunit
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.RECEPTOR.CHRNB3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Neuronal acetylcholine receptor subunit beta-3
member entity reference: Cholinergic receptor nicotinic beta 3 subunit

CHRNB2
type: Complex
component stoichiometry: CHRNB2 s170 sa110 STOICHIOMETRY ID COMPLEX
component: CHRNB2
feature: COMPLEX PARTICIPANT BINDING FEATURE s170 sa110 292

K+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

CHRNA4
type: Protein
entity reference: CHRNA4
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa111 236
comment: SPECIES_TYPE=PROTEIN

DRD2/ DRD3/ DRD4
type: Protein
entity reference: DRD2/ DRD3/ DRD4
feature: COMPLEX PARTICIPANT BINDING FEATURE s196 sa79 248
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2Q056 180
type: UnificationXref
id: H2Q056
db: uniprot

CHRNA6
type: ProteinReference
xref: P06592
standard name: Nicotinic acetylcholine receptor alpha 6 subunit
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.RECEPTOR.CHRNA6
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Neuronal acetylcholine receptor subunit alpha-6
member entity reference: Uncharacterized protein

uniprot Q05901 174
type: UnificationXref
id: Q05901
db: uniprot

PTHR24056:SF46
type: RelationshipXref
id: PTHR24056:SF46
db: PANTHER Family
relationship type: By Homology

CLIC6 s50 sa72 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CLIC6
stoichiometric coefficient: 1.0

EPB41L2
type: ProteinReference
xref: P06598
standard name: Erythrocyte membrane protein band 4.1-like 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.EPB41L2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: EPB41L2 isoform 1
member entity reference: Band 4.1-like protein 2
member entity reference: Uncharacterized protein
member entity reference: Erythrocyte membrane protein band 4.1-like 2

uniprot A0A1D5QRT8 50
type: UnificationXref
id: A0A1D5QRT8
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re19
control type: ACTIVATION
controller: KCNK3/9

PTHR46037:SF4
type: RelationshipXref
id: PTHR46037:SF4
db: PANTHER Family
relationship type: By Homology

ADCY2
type: Protein
entity reference: ADCY2
feature: ACTIVE 24
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 31

00696
type: UnificationXref
id: MOD:00696
db: mod

PTHR11003:SF138
type: RelationshipXref
id: PTHR11003:SF138
db: PANTHER Family
relationship type: By Homology

DRD2/ DRD3/ DRD4
type: Protein
entity reference: DRD2/ DRD3/ DRD4
feature: COMPLEX PARTICIPANT BINDING FEATURE s191 sa62 196
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

D(2) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF87
xref: uniprot P20288 118
organism: Bos taurus

…
type: Stoichiometry
physical entity: CHRNB2
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re28 320
type: Stoichiometry
physical entity: D3/EPB41L2 complex
stoichiometric coefficient: 1.0

Thr75 PPP1R1B s242 sa117 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Thr75
feature location: Thr75 PPP1R1B s242 sa117 rs2 Thr75
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Thr75
comment: MODIFICATION_RESIDUE_ANGLE=5.045894450503827

D(4) dopamine receptor
type: ProteinReference
xref: uniprot P21917 119
xref: PTHR24247:SF205
organism: Homo sapiens

nicotine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa10 270
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re14 370
type: Stoichiometry
physical entity: ADCY2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re14 371
type: Stoichiometry
physical entity: ADCY2
stoichiometric coefficient: 1.0

CHRNA3 CHRNB4 complex s162 csa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA3/CHRNB4 complex
stoichiometric coefficient: 1.0

DISSOCIATION
type: RelationshipTypeVocabulary

PTHR24248:SF154
type: RelationshipXref
id: PTHR24248:SF154
db: PANTHER Family
relationship type: By Homology

PTHR19850:SF29
type: RelationshipXref
id: PTHR19850:SF29
db: PANTHER Family
relationship type: By Homology

PTHR38537:SF5
type: RelationshipXref
id: PTHR38537:SF5
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PPP1R1B-RIGHT__PPP1R1B-_re45
controller: CDK5

CHRNA4/CHRNB2/CHRNA6/CHRNB3 complex
type: Complex
component stoichiometry: CHRNA4 s30 sa111 STOICHIOMETRY ID COMPLEX
component stoichiometry: CHRNB3 s139 sa114 STOICHIOMETRY ID COMPLEX
component stoichiometry: CHRNA6 s135 sa113 STOICHIOMETRY ID COMPLEX
component: CHRNB3
component: CHRNA4
component: CHRNB2
component: CHRNA6
feature: COMPLEX BINDING FEATURE s172 csa21 237
feature: COMPLEX PARTICIPANT BINDING FEATURE s172 csa21 244
feature: COMPLEX BINDING FEATURE s172 csa21 239
feature: COMPLEX BINDING FEATURE s172 csa21 241
feature: ACTIVE 24
feature: COMPLEX BINDING FEATURE s172 csa21 235
cellular location: cytosol

Uncharacterized protein
type: ProteinReference
xref: PTHR18945:SF82
xref: uniprot A0A1D5QJI6 47
organism: Macaca mulatta

nicotine/ CHRNA4/CHRNB2 complex
type: Complex
component stoichiometry: nicotine s115 sa94 STOICHIOMETRY ID COMPLEX
component stoichiometry: CHRNA4 CHRNB2 complex s168 csa20 STOICHIOMETRY ID COMPLEX
component: nicotine
component: CHRNA4/CHRNB2 complex
feature: COMPLEX BINDING FEATURE s152 csa16 295
feature: COMPLEX BINDING FEATURE s152 csa16 293
cellular location: cytosol

uniprot P61168 124
type: UnificationXref
id: P61168
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P50146 158
organism: Gallus gallus

PTHR11003:SF75
type: RelationshipXref
id: PTHR11003:SF75
db: PANTHER Family
relationship type: By Homology

K+
type: SmallMolecule
comment: SPECIES_TYPE=ION

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR45628:SF10
xref: uniprot F1Q382 84
organism: Canis lupus familiaris

FLNA s70 sa80 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FLNA
stoichiometric coefficient: 1.0

KCNK3/9
type: ProteinReference
xref: P06605
standard name: Potassium channel subfamily K member 3 and 9
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.ION_CHANNEL.KCNK3_slash_9
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Potassium channel subfamily K member 9
member entity reference: Potassium channel subfamily K member 3
member entity reference: Potassium channel subfamily K member
member entity reference: Potassium two pore domain channel subfamily K member 9

uniprot P50146 158
type: UnificationXref
id: P50146
db: uniprot

Chloride intracellular channel protein 6
type: ProteinReference
xref: uniprot Q96NY7 170
xref: PTHR45476:SF1
organism: Homo sapiens

TRANSPORT_LEFT__epinephrine-RIGHT__epinephrine-_re8
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 336
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 337
left: epinephrine
interaction type: TRANSPORT
right: epinephrine

FLNA
type: Protein
entity reference: FLNA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PPP1R1B
type: Protein
entity reference: PPP1R1B
feature: Thr34 PPP1R1B s242 sa117 rs1
feature: Thr75 PPP1R1B s242 sa117 rs2
feature: ACTIVE 24
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9606 19
type: UnificationXref
id: 9606
db: ncbitaxon

CHRNB2 s255 sa125 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNB2
stoichiometric coefficient: 2.0

uniprot P21333 96
type: UnificationXref
id: P21333
db: uniprot

bloodstream c3
type: CellularLocationVocabulary
comment: bloodstream

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P27791 20
organism: Rattus norvegicus

uniprot F6Q8V4 168
type: UnificationXref
id: F6Q8V4
db: uniprot

nicotine s115 sa94 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: nicotine
stoichiometric coefficient: 1.0

GialphaGbetaGgamma complex
type: Complex
component stoichiometry: GNB s210 sa67 STOICHIOMETRY ID COMPLEX
component stoichiometry: GNG s214 sa68 STOICHIOMETRY ID COMPLEX
component stoichiometry: GNAI s220 sa66 STOICHIOMETRY ID COMPLEX
component: GNB
component: GNG
component: GNAI
feature: COMPLEX BINDING FEATURE s223 csa6 277
feature: COMPLEX BINDING FEATURE s223 csa6 275
feature: COMPLEX BINDING FEATURE s223 csa6 279
cellular location: cytosol

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot P27791 20
type: UnificationXref
id: P27791
db: uniprot

Growth factor receptor-bound protein 2a
type: ProteinReference
xref: PTHR46037:SF4
xref: uniprot Q5RKN6 70
organism: Danio rerio

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: depolarization
controller: Na+

DRD3/DRD4-GRB2 complex
type: Complex
component stoichiometry: DRD2 DRD3 DRD4 s197 sa82 STOICHIOMETRY ID COMPLEX
component stoichiometry: GRB2 s76 sa81 STOICHIOMETRY ID COMPLEX
component: DRD2/ DRD3/ DRD4
component: GRB2
feature: COMPLEX BINDING FEATURE s235 csa13 217
feature: COMPLEX BINDING FEATURE s235 csa13 215
cellular location: cytosol

TH isoform 6
type: ProteinReference
xref: uniprot H2Q2W7 191
xref: PTHR11473:SF18
organism: Pan troglodytes

CHRNA5
type: ProteinReference
xref: P06593
standard name: Nicotinic acetylcholine receptor alpha 5 subunit
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.RECEPTOR.CHRNA5
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Neuronal acetylcholine receptor subunit alpha-5
member entity reference: Cholinergic receptor nicotinic alpha 5 subunit
member entity reference: Uncharacterized protein

Band 4.1-like protein 2
type: ProteinReference
xref: PTHR23280:SF17
xref: uniprot O43491 76
organism: Homo sapiens

EPB41L2
type: Protein
entity reference: EPB41L2
feature: COMPLEX PARTICIPANT BINDING FEATURE s66 sa78 234
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__KCNK3_9-RIGHT__KCNK3_9-_re18
control type: ACTIVATION
controller: PRKACA

Voltage-dependent T-type calcium channel subunit alpha-1G
type: ProteinReference
xref: uniprot O43497 88
xref: PTHR10037:SF137
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re49 361
type: Stoichiometry
physical entity: CHRNA4/CHRNB2/CHRNA6/CHRNB3 complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re49 362
type: Stoichiometry
physical entity: nicotine/CHRNA4/CHRNB2/CHRNA6/CHRNB3 complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re49 360
type: Stoichiometry
physical entity: nicotine
stoichiometric coefficient: 1.0

eco ECO:0000250 9
type: UnificationXref
id: ECO:0000250
db: eco

PTHR11668:SF377
type: RelationshipXref
id: PTHR11668:SF377
db: PANTHER Family
relationship type: By Homology

uniprot P62873 43
type: UnificationXref
id: P62873
db: uniprot

uniprot C3Z434 100
type: UnificationXref
id: C3Z434
db: uniprot

uniprot H2Q2M8 129
type: UnificationXref
id: H2Q2M8
db: uniprot

uniprot A9JTC8 154
type: UnificationXref
id: A9JTC8
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63213 34
xref: PTHR13809:SF25
organism: Mus musculus

increase blood pressure
type: Pathway

PARTICIPANT STOICHIOMETRY re35 396
type: Stoichiometry
physical entity: nicotine/ CHRNA4/CHRNB2 complex
stoichiometric coefficient: 1.0

ncbitaxon 8364 36
type: UnificationXref
id: 8364
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re35 395
type: Stoichiometry
physical entity: CHRNA4/CHRNB2 complex
stoichiometric coefficient: 1.0

uniprot A0A1D5QEV2 72
type: UnificationXref
id: A0A1D5QEV2
db: uniprot

uniprot Q15825 49
type: UnificationXref
id: Q15825
db: uniprot

PARTICIPANT STOICHIOMETRY re39 388
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR45628:SF10
xref: uniprot H2Q573 87
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re39 389
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

CHRNA4 s166 sa90 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA4
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION_LEFT__DRD2_DRD3_DRD4_G_protein_complex-_Dopamine-RIGHT__dopamine_DRD2_DRD3_DRD4_G_protein_complex-_re15
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 365
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 366
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 367
left: DRD2 DRD3 DRD4 G-protein complex
left: Dopamine
interaction type: HETERODIMER_ASSOCIATION
right: dopamine DRD2 DRD3 DRD4 G-protein complex

EPB41L2 isoform 1
type: ProteinReference
xref: PTHR23280:SF17
xref: uniprot H2QTQ8 75
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re35 394
type: Stoichiometry
physical entity: nicotine
stoichiometric coefficient: 1.0

G protein subunit alpha i1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot A0A2I3S4R3 153
organism: Pan troglodytes

nicotine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

D(4) dopamine receptor
type: ProteinReference
xref: uniprot P51436 122
xref: PTHR24247:SF205
organism: Mus musculus

HETERODIMER_ASSOCIATION_LEFT__GialphaGbetaGgamma_complex-_DRD2__DRD3__DRD4-RIGHT__DRD2_DRD3_DRD4_G_protein_complex-_re31
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 405
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 403
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 404
left: GialphaGbetaGgamma complex
left: DRD2/ DRD3/ DRD4
interaction type: HETERODIMER_ASSOCIATION
right: DRD2 DRD3 DRD4 G-protein complex

PARTICIPANT STOICHIOMETRY re22 338
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24248:SF87
xref: uniprot F7CYH8 115
organism: Macaca mulatta

GNG
type: Protein
entity reference: GNG
feature: COMPLEX PARTICIPANT BINDING FEATURE s213 sa65 202
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CHRNB2
type: Protein
entity reference: CHRNB2

uniprot A0A2K6HRQ5 48
type: UnificationXref
id: A0A2K6HRQ5
db: uniprot

PARTICIPANT STOICHIOMETRY re22 339
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

GNAI s217 sa31 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re44 376
type: Stoichiometry
physical entity: PPP1CA
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: increase blood pressure
controller: epinephrine

high blood glucose level
type: Pathway

PARTICIPANT STOICHIOMETRY re44 377
type: Stoichiometry
physical entity: PPP1CA
stoichiometric coefficient: 1.0

CHRNA5
type: Protein
entity reference: CHRNA5
feature: COMPLEX PARTICIPANT BINDING FEATURE s263 sa123 214
comment: SPECIES_TYPE=PROTEIN

EPB41L1
type: Protein
entity reference: EPB41L1
feature: COMPLEX PARTICIPANT BINDING FEATURE s61 sa76 300
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

eco ECO:0000245 26
type: UnificationXref
id: ECO:0000245
db: eco

uniprot P48193 147
type: UnificationXref
id: P48193
db: uniprot

STATE_TRANSITION_LEFT__dopamine_DRD2_DRD3_DRD4_G_protein_complex-_GTP-RIGHT__dopamine_DRD2_DRD3_DRD4_complex-_GNAI-_GDP-_Gbeta_Ggamma_complex-_re42
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 384
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 382
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 383
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 385
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 386
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 387
left: GTP
left: dopamine DRD2 DRD3 DRD4 G-protein complex
interaction type: STATE_TRANSITION
right: GNAI
right: Gbeta Ggamma complex
right: GDP
right: dopamine DRD2 DRD3 DRD4 complex

TRANSPORT
type: RelationshipTypeVocabulary

SLC18A2
type: Protein
entity reference: SLC18A2
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 26

HETERODIMER_ASSOCIATION_LEFT__DRD2__DRD3__DRD4-_EPB41L2-RIGHT__D3_EPB41L2_complex-_re28
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 319
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 318
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 320
left: EPB41L2
left: DRD2/ DRD3/ DRD4
interaction type: HETERODIMER_ASSOCIATION
right: D3/EPB41L2 complex

GNAI
type: Protein
entity reference: GNAI
feature: GNAI s219 sa63 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s219 sa63 198
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GNAI s219 sa63 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GNAI
stoichiometric coefficient: 1.0

Protein phosphatase 1 regulatory subunit 1B
type: ProteinReference
xref: PTHR15417:SF2
xref: uniprot Q60829 25
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re1 353
type: Stoichiometry
physical entity: nicotine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 355
type: Stoichiometry
physical entity: nicotine/ CHRNA3/CHRNB4 complex
stoichiometric coefficient: 1.0

K+
type: SmallMolecule
comment: SPECIES_TYPE=ION

PARTICIPANT STOICHIOMETRY re1 354
type: Stoichiometry
physical entity: CHRNA3/CHRNB4 complex
stoichiometric coefficient: 1.0

GO GO:0005829 3
type: UnificationXref
id: GO:0005829
db: GO

PARTICIPANT STOICHIOMETRY re30 406
type: Stoichiometry
physical entity: GRB2
stoichiometric coefficient: 1.0

uniprot F1PMQ9 114
type: UnificationXref
id: F1PMQ9
db: uniprot

PARTICIPANT STOICHIOMETRY re30 407
type: Stoichiometry
physical entity: DRD2/ DRD3/ DRD4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re30 408
type: Stoichiometry
physical entity: DRD3/DRD4-GRB2 complex
stoichiometric coefficient: 1.0

uniprot P43681 59
type: UnificationXref
id: P43681
db: uniprot

uniprot E9G7U7 102
type: UnificationXref
id: E9G7U7
db: uniprot

uniprot Q8BTM8 97
type: UnificationXref
id: Q8BTM8
db: uniprot

DRD2/DRD3 EPB41L1 complex
type: Complex
component stoichiometry: EPB41L1 s61 sa76 STOICHIOMETRY ID COMPLEX
component stoichiometry: DRD2 DRD3 DRD4 s194 sa75 STOICHIOMETRY ID COMPLEX
component: DRD2/ DRD3/ DRD4
component: EPB41L1
feature: COMPLEX BINDING FEATURE s233 csa10 299
feature: COMPLEX BINDING FEATURE s233 csa10 297
cellular location: cytosol

STATE_TRANSITION_LEFT__DOPA-RIGHT__Dopamine-_re22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 339
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 338
left: DOPA
interaction type: STATE_TRANSITION
right: Dopamine

K+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

uniprot O70318 77
type: UnificationXref
id: O70318
db: uniprot

uniprot F6VE51 133
type: UnificationXref
id: F6VE51
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 101

P06600
type: UnificationXref
id: P06600
db: PANTHER Pathway Component

P06601
type: UnificationXref
id: P06601
db: PANTHER Pathway Component

P06602
type: UnificationXref
id: P06602
db: PANTHER Pathway Component

CHRNA4
type: Complex
component stoichiometry: CHRNA4 s166 sa90 STOICHIOMETRY ID COMPLEX
component: CHRNA4
feature: COMPLEX PARTICIPANT BINDING FEATURE s166 sa90 302
cellular location: cytosol

P06603
type: UnificationXref
id: P06603
db: PANTHER Pathway Component

cAMP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 9

uniprot P63096 160
type: UnificationXref
id: P63096
db: uniprot

CHRNA3
type: Complex
component stoichiometry: CHRNA3 s163 sa107 STOICHIOMETRY ID COMPLEX
component: CHRNA3
feature: COMPLEX PARTICIPANT BINDING FEATURE s163 sa107 264

PARTICIPANT STOICHIOMETRY re19 356
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

CHRNA3
type: Complex
component stoichiometry: CHRNA3 s7 sa11 STOICHIOMETRY ID COMPLEX
component: CHRNA3
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa11 272
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re19 357
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

Voltage-dependent T-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot F1MR37 83
xref: PTHR45628:SF15
organism: Bos taurus

CHRNA4
type: Complex
component stoichiometry: CHRNA4 s169 sa109 STOICHIOMETRY ID COMPLEX
component: CHRNA4
feature: COMPLEX PARTICIPANT BINDING FEATURE s169 sa109 290

SNARE complex
type: Complex
cellular location: synaptic vesicle

Neuronal acetylcholine receptor subunit alpha-5
type: ProteinReference
xref: PTHR18945:SF76
xref: uniprot P20420 52
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__KCNK3_9-RIGHT__KCNK3_9-_re18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 359
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 358
left: KCNK3/9
interaction type: STATE_TRANSITION
right: KCNK3/9

nicotine s259 sa128 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: nicotine
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__SNARE_complex-RIGHT__SNARE_complex-_re46
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re46 368
participant stoichiometry: PARTICIPANT STOICHIOMETRY re46 369
left: SNARE complex
interaction type: STATE_TRANSITION
right: SNARE complex

uniprot Q9UD71 27
type: UnificationXref
id: Q9UD71
db: uniprot

Ca2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P00517 13
xref: PTHR24353:SF82
organism: Bos taurus

uniprot F6PVT7 38
type: UnificationXref
id: F6PVT7
db: uniprot

uniprot P04177 192
type: UnificationXref
id: P04177
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 8

GNAI
type: Protein
entity reference: GNAI
feature: GNAI s217 sa31 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q2MKA5 55
type: UnificationXref
id: Q2MKA5
db: uniprot

uniprot F7FXA9 39
type: UnificationXref
id: F7FXA9
db: uniprot

SNARE complex
type: Complex
feature: ACTIVE 24
cellular location: synaptic vesicle

PARTICIPANT STOICHIOMETRY re34 397
type: Stoichiometry
physical entity: GNAI
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re34 399
type: Stoichiometry
physical entity: GialphaGbetaGgamma complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re34 398
type: Stoichiometry
physical entity: Gbeta Ggamma complex
stoichiometric coefficient: 1.0

uniprot G3N1D1 135
type: UnificationXref
id: G3N1D1
db: uniprot

Thr34 PPP1R1B s241 sa115 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Thr34
feature location: Thr34 PPP1R1B s241 sa115 rs1 Thr34
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.065590492880909
comment: MODIFICATION_RESIDUE_NAME=Thr34

GNB
type: Protein
entity reference: GNB
feature: COMPLEX PARTICIPANT BINDING FEATURE s210 sa67 278
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

epinephrine
type: SmallMolecule
cellular location: vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
type: ProteinReference
xref: uniprot A3KMS9 5
organism: Danio rerio

CHRNA4
type: Protein
entity reference: CHRNA4
feature: COMPLEX PARTICIPANT BINDING FEATURE s261 sa121 210
comment: SPECIES_TYPE=PROTEIN

uniprot F7BWK5 74
type: UnificationXref
id: F7BWK5
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot B2RSH2 155
organism: Mus musculus

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot A0A1D5RHE7 140
organism: Macaca mulatta

ncbitaxon 7955 6
type: UnificationXref
id: 7955
db: ncbitaxon

ACTIVE 24
type: EntityFeature
comment: Active state

uniprot P61169 125
type: UnificationXref
id: P61169
db: uniprot

uniprot H2QFK0 11
type: UnificationXref
id: H2QFK0
db: uniprot

uniprot O35111 137
type: UnificationXref
id: O35111
db: uniprot

GNAI s220 sa66 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CHRNB2 s262 sa122 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNB2
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re17 363
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DF43 35
xref: PTHR13809:SF25
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY re17 364
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

ncbitaxon 7739 101
type: UnificationXref
id: 7739
db: ncbitaxon

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P05132 15
xref: PTHR24353:SF82
organism: Mus musculus

…
type: Stoichiometry
physical entity: CHRNB4
stoichiometric coefficient: 3.0

HETERODIMER_ASSOCIATION_LEFT__nicotine-_CHRNA3_CHRNB4_complex-RIGHT__nicotine__CHRNA3_CHRNB4_complex-_re1
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 353
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 355
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 354
left: CHRNA3/CHRNB4 complex
left: nicotine
interaction type: HETERODIMER_ASSOCIATION
right: nicotine/ CHRNA3/CHRNB4 complex

uniprot A0A1D5RJP1 190
type: UnificationXref
id: A0A1D5RJP1
db: uniprot

PRKACA
type: Protein
entity reference: PRKACA
feature: ACTIVE 24
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7GMZ4 179
type: UnificationXref
id: F7GMZ4
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__CLIC6-_DRD2__DRD3__DRD4-RIGHT__DRD2_DRD3_DRD4_CLIC6_complex-_re25
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 328
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 329
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 327
left: CLIC6
left: DRD2/ DRD3/ DRD4
interaction type: HETERODIMER_ASSOCIATION
right: DRD2 DRD3 DRD4 CLIC6 complex

CHRNA4/CHRNB2 complex
type: Complex
component stoichiometry: HOMODIMER ID 61STOICHIOMETRY ID COMPLEX
component: CHRNB2
component: CHRNA4
feature: COMPLEX BINDING FEATURE s145 csa15 303
feature: COMPLEX BINDING FEATURE s145 csa15 301
cellular location: cytosol

STATE_TRANSITION_LEFT__GNAI-RIGHT__P-_GNAI-_re33
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 402
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 401
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 400
left: GNAI
interaction type: STATE_TRANSITION
right: GNAI
right: P

uniprot P20288 118
type: UnificationXref
id: P20288
db: uniprot

uniprot F1MR37 83
type: UnificationXref
id: F1MR37
db: uniprot

uniprot A0A3Q1MJN8 177
type: UnificationXref
id: A0A3Q1MJN8
db: uniprot

PARTICIPANT STOICHIOMETRY re50 346
type: Stoichiometry
physical entity: nicotine
stoichiometric coefficient: 1.0

PTHR23506:SF30
type: RelationshipXref
id: PTHR23506:SF30
db: PANTHER Family
relationship type: By Homology

GO GO:0031982 2
type: UnificationXref
id: GO:0031982
db: GO

PARTICIPANT STOICHIOMETRY re50 348
type: Stoichiometry
physical entity: nicotine CHRNA4/CHRNB2/CHRNA5 complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re50 347
type: Stoichiometry
physical entity: CHRNA4/CHRNB2/CHRNA5 complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re13 374
type: Stoichiometry
physical entity: PRKACA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re43 380
type: Stoichiometry
physical entity: PPP1R1B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re43 381
type: Stoichiometry
physical entity: PPP1R1B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re13 375
type: Stoichiometry
physical entity: PRKACA
stoichiometric coefficient: 1.0

uniprot F6QDH4 178
type: UnificationXref
id: F6QDH4
db: uniprot

FLNA
type: ProteinReference
xref: P06601
standard name: Filamin A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.FLNA
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Filamin-A isoform 2
member entity reference: Uncharacterized protein
member entity reference: Filamin A
member entity reference: Filamin-A

uniprot P12390 181
type: UnificationXref
id: P12390
db: uniprot

GNAI
type: Protein
entity reference: GNAI
feature: GNAI s216 sa30 rs1
feature: ACTIVE 24
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

eco ECO:0000304 17
type: UnificationXref
id: ECO:0000304
db: eco

Danio rerio
type: BioSource
xref: ncbitaxon 7955 6

uniprot P51436 122
type: UnificationXref
id: P51436
db: uniprot

CHRNB2
type: Protein
entity reference: CHRNB2

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot Q8MJ44 22
xref: PTHR24353:SF82
organism: Canis lupus familiaris

DRD2 DRD3 DRD4 s194 sa75 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DRD2/ DRD3/ DRD4
stoichiometric coefficient: 1.0

UNKNOWN_INHIBITION
type: RelationshipTypeVocabulary

uniprot F7FNW0 149
type: UnificationXref
id: F7FNW0
db: uniprot

uniprot Q5RKN6 70
type: UnificationXref
id: Q5RKN6
db: uniprot

GO GO:0008021 4
type: UnificationXref
id: GO:0008021
db: GO

CHRNA4 s261 sa121 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA4
stoichiometric coefficient: 1.0

uniprot A0A2I3S2C9 167
type: UnificationXref
id: A0A2I3S2C9
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__nicotine-_CHRNA4_CHRNB2_complex-RIGHT__nicotine__CHRNA4_CHRNB2_complex-_re35
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 395
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 396
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 394
left: nicotine
left: CHRNA4/CHRNB2 complex
interaction type: HETERODIMER_ASSOCIATION
right: nicotine/ CHRNA4/CHRNB2 complex

Na+
type: SmallMolecule
comment: SPECIES_TYPE=ION

uniprot P17612 18
type: UnificationXref
id: P17612
db: uniprot

PARTICIPANT STOICHIOMETRY re3 349
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

ncbitaxon 9913 14
type: UnificationXref
id: 9913
db: ncbitaxon

CACNA
type: Protein
entity reference: CACNA
feature: ACTIVE 24
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Synaptic vesicular amine transporter
type: ProteinReference
xref: PTHR23506:SF30
xref: uniprot Q8BRU6 132
organism: Mus musculus

CACNA
type: ProteinReference
xref: P06600
standard name: Voltage-dependent calcium channel subunit alpha
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.ION_CHANNEL.CACNA
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Voltage-dependent T-type calcium channel subunit alpha
member entity reference: Voltage-dependent L-type calcium channel subunit alpha
member entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C
member entity reference: Voltage-dependent T-type calcium channel subunit alpha-1G

PARTICIPANT STOICHIOMETRY re12 378
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re12 379
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

CHRNA4
type: ProteinReference
xref: P06594
standard name: Nicotinic acetylcholine receptor alpha 4 subunit
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.RECEPTOR.CHRNA4
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Neuronal acetylcholine receptor subunit alpha-4
member entity reference: Cholinergic receptor nicotinic alpha 4 subunit

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__PRKACA-RIGHT__PRKACA-_re13
control type: INHIBITION
controller: PPP1R1B

P
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

PRKACA
type: Protein
entity reference: PRKACA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CACNA
type: Protein
entity reference: CACNA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P63097 161
organism: Bos taurus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__SNARE_complex-RIGHT__SNARE_complex-_re46
control type: ACTIVATION
controller: depolarization

nicotine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s259 sa128 222
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P63096 160
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re6 344
type: Stoichiometry
physical entity: CACNA
stoichiometric coefficient: 1.0

uniprot Q5IS72 126
type: UnificationXref
id: Q5IS72
db: uniprot

PARTICIPANT STOICHIOMETRY re6 345
type: Stoichiometry
physical entity: CACNA
stoichiometric coefficient: 1.0

uniprot E9HKA6 104
type: UnificationXref
id: E9HKA6
db: uniprot

GNB s208 sa60 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GNB
stoichiometric coefficient: 1.0

Chloride intracellular channel protein
type: ProteinReference
xref: PTHR45476:SF1
xref: uniprot A0A2I3S2C9 167
organism: Pan troglodytes

CHRNB3
type: Protein
entity reference: CHRNB3
feature: COMPLEX PARTICIPANT BINDING FEATURE s139 sa114 242
comment: SPECIES_TYPE=PROTEIN

depolarization
type: Pathway

GNG s213 sa65 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GNG
stoichiometric coefficient: 1.0

uniprot F7AT89 58
type: UnificationXref
id: F7AT89
db: uniprot

TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re37
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 391
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 390
left: K+
interaction type: TRANSPORT
right: K+

Potassium channel subfamily K member
type: ProteinReference
xref: PTHR11003:SF138
xref: uniprot F6ZSC2 134
organism: Monodelphis domestica

Voltage-dependent T-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot Q5SUF7 91
xref: PTHR10037:SF137
organism: Mus musculus

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re3
control type: ACTIVATION
controller: CHRNA3/CHRNB4 complex

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 21

DRD2/DRD3-FLNA complex
type: Complex
component stoichiometry: FLNA s70 sa80 STOICHIOMETRY ID COMPLEX
component stoichiometry: DRD2 DRD3 DRD4 s196 sa79 STOICHIOMETRY ID COMPLEX
component: DRD2/ DRD3/ DRD4
component: FLNA
feature: COMPLEX BINDING FEATURE s234 csa12 247
feature: COMPLEX BINDING FEATURE s234 csa12 249
cellular location: cytosol

uniprot Q5IS77 60
type: UnificationXref
id: Q5IS77
db: uniprot

DRD2 DRD3 DRD4 s197 sa82 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DRD2/ DRD3/ DRD4
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 103

INHIBITION
type: RelationshipTypeVocabulary

HETERODIMER_ASSOCIATION_LEFT__nicotine-_CHRNA4_CHRNB2_CHRNA5_complex-RIGHT__nicotine_CHRNA4_CHRNB2_CHRNA5_complex-_re50
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re50 346
participant stoichiometry: PARTICIPANT STOICHIOMETRY re50 348
participant stoichiometry: PARTICIPANT STOICHIOMETRY re50 347
left: nicotine
left: CHRNA4/CHRNB2/CHRNA5 complex
interaction type: HETERODIMER_ASSOCIATION
right: nicotine CHRNA4/CHRNB2/CHRNA5 complex

uniprot P04757 64
type: UnificationXref
id: P04757
db: uniprot

CHRNB2 s170 sa110 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNB2
stoichiometric coefficient: 3.0

GNB s209 sa64 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GNB
stoichiometric coefficient: 1.0

Filamin-A isoform 2
type: ProteinReference
xref: PTHR38537:SF5
xref: uniprot F7GCM2 95
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re3 350
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

Growth factor receptor-bound protein 2
type: ProteinReference
xref: PTHR46037:SF4
xref: uniprot Q66II3 71
organism: Xenopus tropicalis

ncbitaxon 10116 21
type: UnificationXref
id: 10116
db: ncbitaxon

Neuronal acetylcholine receptor subunit alpha-3
type: ProteinReference
xref: uniprot P32297 65
xref: PTHR18945:SF831
organism: Homo sapiens

TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re19
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 356
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 357
left: K+
interaction type: TRANSPORT
right: K+

uniprot P60026 123
type: UnificationXref
id: P60026
db: uniprot

CHRNB2 s174 sa103 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNB2
stoichiometric coefficient: 2.0

nicotine/ CHRNA3/CHRNB4 complex
type: Complex
component stoichiometry: nicotine s5 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: CHRNA3 CHRNB4 complex s162 csa19 STOICHIOMETRY ID COMPLEX
component: nicotine
component: CHRNA3/CHRNB4 complex
feature: COMPLEX BINDING FEATURE s151 csa1 267
feature: COMPLEX BINDING FEATURE s151 csa1 269
cellular location: cytosol

uniprot Q07263 66
type: UnificationXref
id: Q07263
db: uniprot

CHRNA4 CHRNB2 CHRNA5 complex s260 csa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA4/CHRNB2/CHRNA5 complex
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__DOPA-_SLC18A2-RIGHT__SCL18A2_DOPA_complex-_re23
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 335
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 334
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 333
left: DOPA
left: SLC18A2
interaction type: HETERODIMER_ASSOCIATION
right: SCL18A2/DOPA complex

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 40
xref: PTHR19850:SF29
organism: Rattus norvegicus

uniprot P63213 34
type: UnificationXref
id: P63213
db: uniprot

By Homology
type: RelationshipTypeVocabulary

…
type: Stoichiometry
physical entity: CHRNB2
stoichiometric coefficient: 2.0

uniprot P59768 32
type: UnificationXref
id: P59768
db: uniprot

Thr34 PPP1R1B s243 sa120 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Thr34
feature location: Thr34 PPP1R1B s243 sa120 rs1 Thr34
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.065590492880909
comment: MODIFICATION_RESIDUE_NAME=Thr34

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__PPP1CA-RIGHT__PPP1CA-_re44
control type: INHIBITION
controller: PPP1R1B

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 45
xref: PTHR19850:SF29
organism: Danio rerio

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot Q7T3D3 162
organism: Danio rerio

depolarization
type: Pathway

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re39
control type: ACTIVATION
controller: CHRNA4/CHRNB2/CHRNA5 complex

uniprot F7G778 63
type: UnificationXref
id: F7G778
db: uniprot

uniprot H2Q6V7 105
type: UnificationXref
id: H2Q6V7
db: uniprot

CHRNB2
type: Protein
entity reference: CHRNB2

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR11668:SF377
xref: uniprot H2Q6V7 105
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR23280:SF17
xref: uniprot F7BWK5 74
organism: Macaca mulatta

PPP1R1B
type: Protein
entity reference: PPP1R1B
feature: Thr75 PPP1R1B s241 sa115 rs2
feature: Thr34 PPP1R1B s241 sa115 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P30729 121
type: UnificationXref
id: P30729
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18945:SF76
xref: uniprot A0A1D5QRT8 50
organism: Macaca mulatta

CHRNB4 s8 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNB4
stoichiometric coefficient: 3.0

uniprot Q9WTP0 81
type: UnificationXref
id: Q9WTP0
db: uniprot

PARTICIPANT STOICHIOMETRY re42 383
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re42 382
type: Stoichiometry
physical entity: dopamine DRD2 DRD3 DRD4 G-protein complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re42 385
type: Stoichiometry
physical entity: GNAI
stoichiometric coefficient: 1.0

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Dopamine-RIGHT__Dopamine-_re17
control type: ACTIVATION
controller: SNARE complex

PARTICIPANT STOICHIOMETRY re42 384
type: Stoichiometry
physical entity: dopamine DRD2 DRD3 DRD4 complex
stoichiometric coefficient: 1.0

Neuronal acetylcholine receptor subunit alpha-6
type: ProteinReference
xref: uniprot Q15825 49
xref: PTHR18945:SF82
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re42 387
type: Stoichiometry
physical entity: Gbeta Ggamma complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re46 368
type: Stoichiometry
physical entity: SNARE complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re42 386
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re46 369
type: Stoichiometry
physical entity: SNARE complex
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__DRD2__DRD3__DRD4-_FLNA-RIGHT__DRD2_DRD3_FLNA_complex-_re29
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 315
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 316
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 317
left: DRD2/ DRD3/ DRD4
left: FLNA
interaction type: HETERODIMER_ASSOCIATION
right: DRD2/DRD3-FLNA complex

CHRNA4
type: Protein
entity reference: CHRNA4
feature: COMPLEX PARTICIPANT BINDING FEATURE s254 sa124 204
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q8BRU6 132
type: UnificationXref
id: Q8BRU6
db: uniprot

uniprot Q3SWW9 110
type: UnificationXref
id: Q3SWW9
db: uniprot

CHRNA4 s30 sa111 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA4
stoichiometric coefficient: 1.0

uniprot A0A2J8JCK6 145
type: UnificationXref
id: A0A2J8JCK6
db: uniprot

UNKNOWN_INHIBITION
type: Control
xref: UNKNOWN INHIBITION
controlled: STATE_TRANSITION_LEFT__SNARE_complex-RIGHT__SNARE_complex-_re46
control type: INHIBITION
controller: PPP1CA

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot P24529 194
type: UnificationXref
id: P24529
db: uniprot

uniprot F1Q382 84
type: UnificationXref
id: F1Q382
db: uniprot

EPB41L1
type: Protein
entity reference: EPB41L1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

EPB41
type: ProteinReference
xref: P06607
standard name: Erythrocyte membrane protein band 4.1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.EPB41
comment: ENTITY_REFERENCE_NOTES=
member entity reference: EPB41 isoform 1
member entity reference: Erythrocyte membrane protein band 4.1
member entity reference: Protein 4.1

uniprot P19020 117
type: UnificationXref
id: P19020
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__ADCY2-RIGHT__ADCY2-_re14
control type: INHIBITION
controller: GNAI

PARTICIPANT STOICHIOMETRY re45 373
type: Stoichiometry
physical entity: PPP1R1B
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P59768 32
xref: PTHR13809:SF25
organism: Homo sapiens

CHRNA4/CHRNB2/CHRNA5 complex
type: Complex
component stoichiometry: CHRNA5 s263 sa123 STOICHIOMETRY ID COMPLEX
component stoichiometry: CHRNA4 s261 sa121 STOICHIOMETRY ID COMPLEX
component: CHRNA4
component: CHRNA5
component: CHRNB2
feature: COMPLEX BINDING FEATURE s260 csa24 213
feature: COMPLEX BINDING FEATURE s260 csa24 209
feature: COMPLEX PARTICIPANT BINDING FEATURE s260 csa24 220
feature: COMPLEX BINDING FEATURE s260 csa24 211
feature: ACTIVE 24
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re45 372
type: Stoichiometry
physical entity: PPP1R1B
stoichiometric coefficient: 1.0

CHRNB4
type: Protein
entity reference: CHRNB4

PARTICIPANT STOICHIOMETRY re29 317
type: Stoichiometry
physical entity: DRD2/DRD3-FLNA complex
stoichiometric coefficient: 1.0

IDA
type: EvidenceCodeVocabulary

PARTICIPANT STOICHIOMETRY re29 316
type: Stoichiometry
physical entity: FLNA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re29 315
type: Stoichiometry
physical entity: DRD2/ DRD3/ DRD4
stoichiometric coefficient: 1.0

GNG
type: ProteinReference
xref: P06590
standard name: Guanine nuceotide-binding protein, gamma 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.GNG
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
member entity reference: Uncharacterized protein

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MJN8 177
xref: PTHR18945:SF80
organism: Bos taurus

Chloride intracellular channel protein 6
type: ProteinReference
xref: PTHR45476:SF1
xref: uniprot Q811Q2 169
organism: Rattus norvegicus

uniprot A0A2I3RMK9 78
type: UnificationXref
id: A0A2I3RMK9
db: uniprot

Thr34 PPP1R1B s242 sa117 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Thr34
feature location: Thr34 PPP1R1B s242 sa117 rs1 Thr34
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.065590492880909
comment: MODIFICATION_RESIDUE_NAME=Thr34

tyrosine
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Dopamine s266 sa58 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

CHRNB2 s31 sa112 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNB2
stoichiometric coefficient: 2.0

ncbitaxon 9598 12
type: UnificationXref
id: 9598
db: ncbitaxon

DRD2/ DRD3/ DRD4
type: Protein
entity reference: DRD2/ DRD3/ DRD4
feature: COMPLEX PARTICIPANT BINDING FEATURE s193 sa73 260
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1N169 93
type: UnificationXref
id: F1N169
db: uniprot

PPP1CA
type: ProteinReference
xref: P06602
standard name: Protein phosphatase 1, catalytic subunit, alpha isoform
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.PPP1CA
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Serine/threonine-protein phosphatase
member entity reference: Serine/threonine-protein phosphatase (Fragment)
member entity reference: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
member entity reference: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
member entity reference: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

D(2) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF87
xref: uniprot P14416 116
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot F7FXA9 39
xref: PTHR19850:SF29
organism: Macaca mulatta

uniprot P07101 193
type: UnificationXref
id: P07101
db: uniprot

Voltage-dependent T-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot F7GWW5 85
xref: PTHR10037:SF137
organism: Macaca mulatta

Tyrosine 3-monooxygenase
type: ProteinReference
xref: PTHR11473:SF18
xref: uniprot P04177 192
organism: Rattus norvegicus

CHRNB2
type: Protein
entity reference: CHRNB2

CHRNA4
type: Protein
entity reference: CHRNA4

Potassium channel subfamily K member 3
type: ProteinReference
xref: PTHR11003:SF138
xref: uniprot O14649 136
organism: Homo sapiens

uniprot C0JPT7 92
type: UnificationXref
id: C0JPT7
db: uniprot

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: high blood glucose level
controller: epinephrine

PTHR11668:SF460
type: RelationshipXref
id: PTHR11668:SF460
db: PANTHER Family
relationship type: By Homology

GNG s215 sa70 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GNG
stoichiometric coefficient: 1.0

Erythrocyte membrane protein band 4.1-like 2
type: ProteinReference
xref: PTHR23280:SF17
xref: uniprot D3ZM69 73
organism: Rattus norvegicus

CLIC6
type: ProteinReference
xref: P06611
standard name: Chloride intracellular channel 6
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.CLIC6
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Chloride intracellular channel protein 6
member entity reference: Chloride intracellular channel protein

uniprot A0A2I3S4R3 153
type: UnificationXref
id: A0A2I3S4R3
db: uniprot

Synaptic vesicular amine transporter
type: ProteinReference
xref: PTHR23506:SF30
xref: uniprot Q01827 130
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION_LEFT__DRD2__DRD3__DRD4-_EPB41L1-RIGHT__DRD2_DRD3_EPB41L1_complex-_re27
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 323
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 322
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 321
left: EPB41L1
left: DRD2/ DRD3/ DRD4
interaction type: HETERODIMER_ASSOCIATION
right: DRD2/DRD3 EPB41L1 complex

CHRNA3 s163 sa107 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA3
stoichiometric coefficient: 2.0

CHRNA4
type: Protein
entity reference: CHRNA4
feature: COMPLEX PARTICIPANT BINDING FEATURE s173 sa102 252
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__Na_PLUS_-RIGHT__Na_PLUS_-_re36
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 393
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 392
left: Na+
interaction type: TRANSPORT
right: Na+

PARTICIPANT STOICHIOMETRY re31 403
type: Stoichiometry
physical entity: GialphaGbetaGgamma complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 341
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re31 404
type: Stoichiometry
physical entity: DRD2/ DRD3/ DRD4
stoichiometric coefficient: 1.0

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re37
control type: ACTIVATION
controller: CHRNA4/CHRNB2 complex

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
type: ProteinReference
xref: PTHR46259:SF1
xref: uniprot P61287 106
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re31 405
type: Stoichiometry
physical entity: DRD2 DRD3 DRD4 G-protein complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 340
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Potassium channel subfamily K member 3
type: ProteinReference
xref: uniprot O54912 138
xref: PTHR11003:SF138
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__DOPA-RIGHT__Dopamine-_re22
controller: DDC

increase heart rate
type: Pathway

ncbitaxon 10228 99
type: UnificationXref
id: 10228
db: ncbitaxon

P06611
type: UnificationXref
id: P06611
db: PANTHER Pathway Component

P06612
type: UnificationXref
id: P06612
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re18 359
type: Stoichiometry
physical entity: KCNK3/9
stoichiometric coefficient: 1.0

P06613
type: UnificationXref
id: P06613
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re18 358
type: Stoichiometry
physical entity: KCNK3/9
stoichiometric coefficient: 1.0

Ca2+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

P06614
type: UnificationXref
id: P06614
db: PANTHER Pathway Component

P06610
type: UnificationXref
id: P06610
db: PANTHER Pathway Component

Neuronal acetylcholine receptor subunit beta-2
type: ProteinReference
xref: uniprot P17787 182
xref: PTHR18945:SF80
organism: Homo sapiens

PTHR10218:SF227
type: RelationshipXref
id: PTHR10218:SF227
db: PANTHER Family
relationship type: By Homology

Dopamine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s158 sa106 230
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

P06609
type: UnificationXref
id: P06609
db: PANTHER Pathway Component

P06608
type: UnificationXref
id: P06608
db: PANTHER Pathway Component

Filamin A
type: ProteinReference
xref: PTHR38537:SF5
xref: uniprot C0JPT7 92
organism: Rattus norvegicus

CHRNB4
type: Protein
entity reference: CHRNB4

P06605
type: UnificationXref
id: P06605
db: PANTHER Pathway Component

dopamine DRD2 DRD3 DRD4 complex
type: Complex
component stoichiometry: Dopamine s158 sa106 STOICHIOMETRY ID COMPLEX
component stoichiometry: DRD2 DRD3 DRD4 s189 sa56 STOICHIOMETRY ID COMPLEX
component: Dopamine
component: DRD2/ DRD3/ DRD4
feature: COMPLEX BINDING FEATURE s203 csa3 229
feature: COMPLEX BINDING FEATURE s203 csa3 227
cellular location: cytosol

P06604
type: UnificationXref
id: P06604
db: PANTHER Pathway Component

P06607
type: UnificationXref
id: P06607
db: PANTHER Pathway Component

uniprot P30926 164
type: UnificationXref
id: P30926
db: uniprot

GNB
type: ProteinReference
xref: P06591
standard name: Guanine nuceotide-binding protein, beta
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.GNB
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Gnb1l protein
member entity reference: G protein subunit beta 1
member entity reference: Uncharacterized protein

P06606
type: UnificationXref
id: P06606
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re27 323
type: Stoichiometry
physical entity: DRD2/DRD3 EPB41L1 complex
stoichiometric coefficient: 1.0

uniprot A3KMS9 5
type: UnificationXref
id: A3KMS9
db: uniprot

Dopamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P62874 44
type: UnificationXref
id: P62874
db: uniprot

DRD2 DRD3 DRD4 s195 sa77 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DRD2/ DRD3/ DRD4
stoichiometric coefficient: 1.0

GNG s214 sa68 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GNG
stoichiometric coefficient: 1.0

Band 4.1-like protein 2
type: ProteinReference
xref: PTHR23280:SF17
xref: uniprot O70318 77
organism: Mus musculus

synaptic vesicle
type: CellularLocationVocabulary
xref: GO GO:0008021 4

PTHR10218:SF230
type: RelationshipXref
id: PTHR10218:SF230
db: PANTHER Family
relationship type: By Homology

Ca2+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: uniprot O88533 150
xref: PTHR11999:SF70
organism: Mus musculus

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 36

Erythrocyte membrane protein band 4.1
type: ProteinReference
xref: PTHR23280:SF12
xref: uniprot A0A0G2K161 144
organism: Rattus norvegicus

DRD2 DRD3 DRD4 s193 sa73 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DRD2/ DRD3/ DRD4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re27 322
type: Stoichiometry
physical entity: EPB41L1
stoichiometric coefficient: 1.0

uniprot P21917 119
type: UnificationXref
id: P21917
db: uniprot

PARTICIPANT STOICHIOMETRY re27 321
type: Stoichiometry
physical entity: DRD2/ DRD3/ DRD4
stoichiometric coefficient: 1.0

DRD2 DRD3 DRD4 s191 sa62 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DRD2/ DRD3/ DRD4
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__nicotine-_CHRNA4_CHRNB2_CHRNA6_CHRNB3_complex-RIGHT__nicotine_CHRNA4_CHRNB2_CHRNA6_CHRNB3_complex-_re49
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re49 361
participant stoichiometry: PARTICIPANT STOICHIOMETRY re49 362
participant stoichiometry: PARTICIPANT STOICHIOMETRY re49 360
left: CHRNA4/CHRNB2/CHRNA6/CHRNB3 complex
left: nicotine
interaction type: HETERODIMER_ASSOCIATION
right: nicotine/CHRNA4/CHRNB2/CHRNA6/CHRNB3 complex

…
type: Stoichiometry
physical entity: CHRNB4
stoichiometric coefficient: 3.0

uniprot P30532 54
type: UnificationXref
id: P30532
db: uniprot

TRIGGER
type: RelationshipTypeVocabulary

GRB2
type: Protein
entity reference: GRB2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P63097 161
type: UnificationXref
id: P63097
db: uniprot

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re7
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 340
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 341
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

HETERODIMER_ASSOCIATION_LEFT__GRB2-_DRD2__DRD3__DRD4-RIGHT__DRD3_DRD4_GRB2_complex-_re30
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 408
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 407
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 406
left: GRB2
left: DRD2/ DRD3/ DRD4
interaction type: HETERODIMER_ASSOCIATION
right: DRD3/DRD4-GRB2 complex

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Na_PLUS_-RIGHT__Na_PLUS_-_re2
control type: ACTIVATION
controller: CHRNA3/CHRNB4 complex

Tyrosine 3-monooxygenase
type: ProteinReference
xref: uniprot P24529 194
xref: PTHR11473:SF18
organism: Mus musculus

…
type: Stoichiometry
physical entity: CHRNB2
stoichiometric coefficient: 2.0

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: uniprot P20711 152
xref: PTHR11999:SF70
organism: Homo sapiens

uniprot P12391 173
type: UnificationXref
id: P12391
db: uniprot

CHRNA3
type: Protein
entity reference: CHRNA3

STATE_TRANSITION_LEFT__PPP1CA-RIGHT__PPP1CA-_re44
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re44 377
participant stoichiometry: PARTICIPANT STOICHIOMETRY re44 376
left: PPP1CA
interaction type: STATE_TRANSITION
right: PPP1CA

…
type: Stoichiometry
physical entity: CHRNB2
stoichiometric coefficient: 2.0

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re7
control type: ACTIVATION
controller: CACNA

uniprot H2QTQ8 75
type: UnificationXref
id: H2QTQ8
db: uniprot

uniprot B3S6H7 98
type: UnificationXref
id: B3S6H7
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR11668:SF300
xref: uniprot E9HKA6 104
organism: Daphnia pulex

EPB41
type: Protein
entity reference: EPB41
feature: COMPLEX PARTICIPANT BINDING FEATURE s55 sa74 262
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

DRD2/ DRD3/ DRD4
type: Protein
entity reference: DRD2/ DRD3/ DRD4
feature: COMPLEX PARTICIPANT BINDING FEATURE s189 sa56 228
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

D(3) dopamine receptor
type: ProteinReference
xref: uniprot P19020 117
xref: PTHR24248:SF154
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QEV2 72
xref: PTHR24056:SF46
organism: Macaca mulatta

PTHR18945:SF75
type: RelationshipXref
id: PTHR18945:SF75
db: PANTHER Family
relationship type: By Homology

PTHR18945:SF76
type: RelationshipXref
id: PTHR18945:SF76
db: PANTHER Family
relationship type: By Homology

uniprot Q6DF43 35
type: UnificationXref
id: Q6DF43
db: uniprot

PTHR46259:SF1
type: RelationshipXref
id: PTHR46259:SF1
db: PANTHER Family
relationship type: By Homology

uniprot F6PGC8 37
type: UnificationXref
id: F6PGC8
db: uniprot

uniprot P30728 120
type: UnificationXref
id: P30728
db: uniprot

PTHR18945:SF80
type: RelationshipXref
id: PTHR18945:SF80
db: PANTHER Family
relationship type: By Homology

uniprot P62138 109
type: UnificationXref
id: P62138
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RJP1 190
xref: PTHR11473:SF18
organism: Macaca mulatta

DOPA
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s84 sa83 282
cellular location: synaptic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F1N611 79
type: UnificationXref
id: F1N611
db: uniprot

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: ProteinReference
xref: PTHR11668:SF472
xref: uniprot Q3SWW9 110
organism: Bos taurus

PTHR18945:SF82
type: RelationshipXref
id: PTHR18945:SF82
db: PANTHER Family
relationship type: By Homology

Neuronal acetylcholine receptor subunit beta-3
type: ProteinReference
xref: uniprot Q5IS75 175
xref: PTHR18945:SF75
organism: Pan troglodytes

Neuronal acetylcholine receptor subunit alpha-4
type: ProteinReference
xref: PTHR18945:SF401
xref: uniprot Q5IS77 60
organism: Pan troglodytes

D(3) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF154
xref: uniprot Q5IS72 126
organism: Pan troglodytes

CHRNA3/CHRNB4 complex
type: Complex
component stoichiometry: HOMODIMER ID 69STOICHIOMETRY ID COMPLEX
component: CHRNB4
component: CHRNA3
feature: COMPLEX BINDING FEATURE s162 csa19 263
feature: COMPLEX PARTICIPANT BINDING FEATURE s162 csa19 268
feature: COMPLEX BINDING FEATURE s162 csa19 265
feature: ACTIVE 24
cellular location: cytosol

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re12
controller: ADCY2

GDP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P62872 42
type: UnificationXref
id: P62872
db: uniprot

ncbitaxon 9615 23
type: UnificationXref
id: 9615
db: ncbitaxon

GRB2
type: Protein
entity reference: GRB2
feature: COMPLEX PARTICIPANT BINDING FEATURE s76 sa81 216
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Neuronal acetylcholine receptor subunit alpha-6
type: ProteinReference
xref: uniprot A0A2K6HRQ5 48
xref: PTHR18945:SF82
organism: Pan troglodytes

DDC
type: ProteinReference
xref: P06608
standard name: DOPA decarboxylase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.DDC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Aromatic-L-amino-acid decarboxylase
member entity reference: Dopa decarboxylase

TH
type: ProteinReference
xref: P06614
standard name: Tyrosine hydroxylase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.TH
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Tyrosine 3-monooxygenase
member entity reference: TH isoform 6
member entity reference: Uncharacterized protein

PARTICIPANT STOICHIOMETRY re15 366
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re26 325
type: Stoichiometry
physical entity: EPB41
stoichiometric coefficient: 1.0

uniprot Q05940 131
type: UnificationXref
id: Q05940
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F6UJE8 156
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re15 367
type: Stoichiometry
physical entity: dopamine DRD2 DRD3 DRD4 G-protein complex
stoichiometric coefficient: 1.0

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__epinephrine-RIGHT__epinephrine-_re8
control type: ACTIVATION
controller: Ca2+

PARTICIPANT STOICHIOMETRY re26 324
type: Stoichiometry
physical entity: DRD2/ DRD3/ DRD4
stoichiometric coefficient: 1.0

uniprot P05132 15
type: UnificationXref
id: P05132
db: uniprot

Neuronal acetylcholine receptor subunit beta-3
type: ProteinReference
xref: uniprot P12391 173
xref: PTHR18945:SF75
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re15 365
type: Stoichiometry
physical entity: DRD2 DRD3 DRD4 G-protein complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re26 326
type: Stoichiometry
physical entity: DRD2/DRD3/DRD4 EBP41 complex
stoichiometric coefficient: 1.0

uniprot F7GDB2 51
type: UnificationXref
id: F7GDB2
db: uniprot

Neuronal acetylcholine receptor subunit beta-2
type: ProteinReference
xref: uniprot P12390 181
xref: PTHR18945:SF80
organism: Rattus norvegicus

Bos taurus
type: BioSource
xref: ncbitaxon 9913 14

STATE_TRANSITION_LEFT__tyrosine-RIGHT__DOPA-_re21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 343
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 342
left: tyrosine
interaction type: STATE_TRANSITION
right: DOPA

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 29

PTHR13809:SF25
type: RelationshipXref
id: PTHR13809:SF25
db: PANTHER Family
relationship type: By Homology

Neuronal acetylcholine receptor subunit alpha-4
type: ProteinReference
xref: PTHR18945:SF401
xref: uniprot P43681 59
organism: Homo sapiens

DRD2/ DRD3/ DRD4
type: Protein
entity reference: DRD2/ DRD3/ DRD4
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q80TL1 143
type: UnificationXref
id: Q80TL1
db: uniprot

Neuronal acetylcholine receptor subunit alpha-5
type: ProteinReference
xref: PTHR18945:SF76
xref: uniprot Q5IS51 56
organism: Pan troglodytes

EPB41 isoform 1
type: ProteinReference
xref: PTHR23280:SF12
xref: uniprot A0A2J8JCK6 145
organism: Pan troglodytes

ncbitaxon 6669 103
type: UnificationXref
id: 6669
db: ncbitaxon

Filamin A
type: ProteinReference
xref: uniprot F1PWW0 94
xref: PTHR38537:SF5
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY re8 337
type: Stoichiometry
physical entity: epinephrine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re8 336
type: Stoichiometry
physical entity: epinephrine
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR38537:SF5
xref: uniprot F1N169 93
organism: Bos taurus

uniprot Q9ERK7 183
type: UnificationXref
id: Q9ERK7
db: uniprot

TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re3
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 350
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 349
left: K+
interaction type: TRANSPORT
right: K+

DDC
type: Protein
entity reference: DDC
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

GNB
type: Protein
entity reference: GNB
feature: COMPLEX PARTICIPANT BINDING FEATURE s208 sa60 312
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CLIC6
type: Protein
entity reference: CLIC6
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GRB2 s76 sa81 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GRB2
stoichiometric coefficient: 1.0

D3/EPB41L2 complex
type: Complex
component stoichiometry: EPB41L2 s66 sa78 STOICHIOMETRY ID COMPLEX
component stoichiometry: DRD2 DRD3 DRD4 s195 sa77 STOICHIOMETRY ID COMPLEX
component: DRD2/ DRD3/ DRD4
component: EPB41L2
feature: COMPLEX BINDING FEATURE s64 csa11 231
feature: COMPLEX BINDING FEATURE s64 csa11 233
cellular location: cytosol

uniprot F6ZAV4 141
type: UnificationXref
id: F6ZAV4
db: uniprot

uniprot Q803H5 46
type: UnificationXref
id: Q803H5
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 23

PTHR18945:SF385
type: RelationshipXref
id: PTHR18945:SF385
db: PANTHER Family
relationship type: By Homology

PTHR11999:SF70
type: RelationshipXref
id: PTHR11999:SF70
db: PANTHER Family
relationship type: By Homology

GNAI s216 sa30 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot Q80TL1 143
organism: Mus musculus

HOMODIMER ID 61STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA4
stoichiometric coefficient: 2.0

uniprot P62137 108
type: UnificationXref
id: P62137
db: uniprot

nicotine s34 sa101 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: nicotine
stoichiometric coefficient: 1.0

uniprot P14416 116
type: UnificationXref
id: P14416
db: uniprot

Cholinergic receptor nicotinic alpha 4 subunit
type: ProteinReference
xref: PTHR18945:SF401
xref: uniprot F7AT89 58
organism: Macaca mulatta

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 159

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PRKACA-RIGHT__PRKACA-_re13
controller: cAMP

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR11668:SF300
xref: uniprot B3S6H7 98
organism: Trichoplax adhaerens

DRD2 DRD3 DRD4 G-protein complex
type: Complex
component stoichiometry: DRD2 DRD3 DRD4 s191 sa62 STOICHIOMETRY ID COMPLEX
component stoichiometry: GNB s209 sa64 STOICHIOMETRY ID COMPLEX
component stoichiometry: GNAI s219 sa63 STOICHIOMETRY ID COMPLEX
component stoichiometry: GNG s213 sa65 STOICHIOMETRY ID COMPLEX
component: GNB
component: GNG
component: DRD2/ DRD3/ DRD4
component: GNAI
feature: COMPLEX BINDING FEATURE s201 csa5 201
feature: COMPLEX BINDING FEATURE s201 csa5 197
feature: COMPLEX BINDING FEATURE s201 csa5 199
feature: COMPLEX BINDING FEATURE s201 csa5 195
cellular location: cytosol

PTHR23280:SF24
type: RelationshipXref
id: PTHR23280:SF24
db: PANTHER Family
relationship type: By Homology

nicotine s5 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: nicotine
stoichiometric coefficient: 1.0

Neuronal acetylcholine receptor subunit beta-3
type: ProteinReference
xref: PTHR18945:SF75
xref: uniprot Q8BMN3 176
organism: Mus musculus

PPP1R1B
type: Protein
entity reference: PPP1R1B
feature: Thr34 PPP1R1B s243 sa120 rs1
feature: Thr75 PPP1R1B s243 sa120 rs2
feature: ACTIVE 24
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot O43491 76
type: UnificationXref
id: O43491
db: uniprot

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR45628:SF10
xref: uniprot F7HT59 86
organism: Macaca mulatta

Dopamine receptor D3
type: ProteinReference
xref: PTHR24248:SF154
xref: uniprot E2R3W6 113
organism: Canis lupus familiaris

uniprot Q7T3D3 162
type: UnificationXref
id: Q7T3D3
db: uniprot

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: depolarization
controller: Na+

DOPA s84 sa83 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

nicotine CHRNA4/CHRNB2/CHRNA5 complex
type: Complex
component stoichiometry: nicotine s259 sa128 STOICHIOMETRY ID COMPLEX
component stoichiometry: CHRNA4 CHRNB2 CHRNA5 complex s260 csa24 STOICHIOMETRY ID COMPLEX
component: CHRNA4/CHRNB2/CHRNA5 complex
component: nicotine
feature: COMPLEX BINDING FEATURE s258 csa26 219
feature: COMPLEX BINDING FEATURE s258 csa26 221
cellular location: cytosol

Solute carrier family 18 (Vesicular monoamine), member 2
type: ProteinReference
xref: PTHR23506:SF30
xref: uniprot B0JYP2 128
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re25 328
type: Stoichiometry
physical entity: DRD2/ DRD3/ DRD4
stoichiometric coefficient: 1.0

HOMODIMER ID 62STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA4
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re25 327
type: Stoichiometry
physical entity: CLIC6
stoichiometric coefficient: 1.0

uniprot Q8BMN3 176
type: UnificationXref
id: Q8BMN3
db: uniprot

PARTICIPANT STOICHIOMETRY re25 329
type: Stoichiometry
physical entity: DRD2 DRD3 DRD4 CLIC6 complex
stoichiometric coefficient: 1.0

GNAI
type: Protein
entity reference: GNAI
feature: COMPLEX PARTICIPANT BINDING FEATURE s220 sa66 276
feature: GNAI s220 sa66 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Dopamine
type: SmallMolecule
cellular location: synaptic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Cholinergic receptor nicotinic beta 3 subunit
type: ProteinReference
xref: PTHR18945:SF75
xref: uniprot F1MF30 171
organism: Bos taurus

GNAI s219 sa63 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

STATE_TRANSITION_LEFT__PPP1R1B-RIGHT__PPP1R1B-_re43
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 380
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 381
left: PPP1R1B
interaction type: STATE_TRANSITION
right: PPP1R1B

…
type: Stoichiometry
physical entity: CHRNB2
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY re37 390
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

uniprot F6VPY1 28
type: UnificationXref
id: F6VPY1
db: uniprot

PARTICIPANT STOICHIOMETRY re37 391
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PPP1R1B-RIGHT__PPP1R1B-_re45
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re45 373
participant stoichiometry: PARTICIPANT STOICHIOMETRY re45 372
left: PPP1R1B
interaction type: STATE_TRANSITION
right: PPP1R1B

CHRNA3 s7 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA3
stoichiometric coefficient: 2.0

PTHR11668:SF472
type: RelationshipXref
id: PTHR11668:SF472
db: PANTHER Family
relationship type: By Homology

GNG
type: Protein
entity reference: GNG
feature: COMPLEX PARTICIPANT BINDING FEATURE s215 sa70 288
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

DRD2 DRD3 DRD4 s192 sa71 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DRD2/ DRD3/ DRD4
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot F6PVT7 38
organism: Monodelphis domestica

KCNK3 9 s226 sa50 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.92
comment: MODIFICATION_RESIDUE_NAME=

nicotine/CHRNA4/CHRNB2/CHRNA6/CHRNB3 complex
type: Complex
component stoichiometry: nicotine s34 sa101 STOICHIOMETRY ID COMPLEX
component stoichiometry: CHRNA4 CHRNB2 CHRNA6 CHRNB3 complex s172 csa21 STOICHIOMETRY ID COMPLEX
component: nicotine
component: CHRNA4/CHRNB2/CHRNA6/CHRNB3 complex
feature: COMPLEX BINDING FEATURE s177 csa17 245
feature: COMPLEX BINDING FEATURE s177 csa17 243
cellular location: cytosol

SLC18A2
type: ProteinReference
xref: P06604
standard name: Solute carrier family 18 member 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.SLC18A2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Synaptic vesicular amine transporter
member entity reference: Uncharacterized protein
member entity reference: SLC18A2 isoform 1
member entity reference: Solute carrier family 18 (Vesicular monoamine), member 2

uniprot E2R3W6 113
type: UnificationXref
id: E2R3W6
db: uniprot

Na+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

SLC18A2
type: Protein
entity reference: SLC18A2
feature: COMPLEX PARTICIPANT BINDING FEATURE s229 sa84 284
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot H2Q2W7 191
type: UnificationXref
id: H2Q2W7
db: uniprot

PTHR15417:SF2
type: RelationshipXref
id: PTHR15417:SF2
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9258 29
type: UnificationXref
id: 9258
db: ncbitaxon

CHRNA6
type: Protein
entity reference: CHRNA6
feature: COMPLEX PARTICIPANT BINDING FEATURE s175 sa104 256
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ASR8 30
xref: PTHR13809:SF52
organism: Macaca mulatta

Neuronal acetylcholine receptor subunit alpha-3
type: ProteinReference
xref: uniprot P04757 64
xref: PTHR18945:SF831
organism: Rattus norvegicus

TH
type: Protein
entity reference: TH
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PPP1R1B
type: ProteinReference
xref: P06589
standard name: Protein phosphatase 1, regulatory subunit 1b
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.PPP1R1B
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein phosphatase 1 regulatory subunit 1B

DRD2 DRD3 DRD4 s189 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DRD2/ DRD3/ DRD4
stoichiometric coefficient: 1.0

GNAI s218 sa59 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GNAI
stoichiometric coefficient: 1.0

Protein kinase cAMP-activated catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H2QFK0 11
organism: Pan troglodytes

PTHR18945:SF401
type: RelationshipXref
id: PTHR18945:SF401
db: PANTHER Family
relationship type: By Homology

Potassium two pore domain channel subfamily K member 9
type: ProteinReference
xref: PTHR11003:SF75
xref: uniprot G3N1D1 135
organism: Bos taurus

ncbitaxon 10090 16
type: UnificationXref
id: 10090
db: ncbitaxon

Potassium channel subfamily K member
type: ProteinReference
xref: uniprot F6VE51 133
xref: PTHR11003:SF75
organism: Macaca mulatta

uniprot O54898 89
type: UnificationXref
id: O54898
db: uniprot

ncbitaxon 9031 159
type: UnificationXref
id: 9031
db: ncbitaxon

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot B0JYP2 128
type: UnificationXref
id: B0JYP2
db: uniprot

DRD2/ DRD3/ DRD4
type: Protein
entity reference: DRD2/ DRD3/ DRD4
feature: COMPLEX PARTICIPANT BINDING FEATURE s195 sa77 232
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GNB
type: Protein
entity reference: GNB
feature: COMPLEX PARTICIPANT BINDING FEATURE s209 sa64 200
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GNG s212 sa61 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GNG
stoichiometric coefficient: 1.0

DRD2/ DRD3/ DRD4
type: Protein
entity reference: DRD2/ DRD3/ DRD4
feature: COMPLEX PARTICIPANT BINDING FEATURE s190 sa57 306
feature: ACTIVE 24
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7HT59 86
type: UnificationXref
id: F7HT59
db: uniprot

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: uniprot P14173 151
xref: PTHR11999:SF70
organism: Rattus norvegicus

CHRNA5
type: Protein
entity reference: CHRNA5
feature: COMPLEX PARTICIPANT BINDING FEATURE s256 sa126 208
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PRKACA-RIGHT__PRKACA-_re13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 375
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 374
left: PRKACA
interaction type: STATE_TRANSITION
right: PRKACA

uniprot F6ZSC2 134
type: UnificationXref
id: F6ZSC2
db: uniprot

Gnb1l protein
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot Q803H5 46
organism: Danio rerio

uniprot Q3T0E7 111
type: UnificationXref
id: Q3T0E7
db: uniprot

uniprot P32297 65
type: UnificationXref
id: P32297
db: uniprot

uniprot Q5IS51 56
type: UnificationXref
id: Q5IS51
db: uniprot

uniprot Q9Z2H5 82
type: UnificationXref
id: Q9Z2H5
db: uniprot

Erythrocyte membrane protein band 4.1 like 1
type: ProteinReference
xref: PTHR23280:SF24
xref: uniprot F1N611 79
organism: Bos taurus

CDK5
type: Protein
entity reference: CDK5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CHRNB2
type: Protein
entity reference: CHRNB2

uniprot P20711 152
type: UnificationXref
id: P20711
db: uniprot

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 99

uniprot P63212 33
type: UnificationXref
id: P63212
db: uniprot

PTHR23280:SF17
type: RelationshipXref
id: PTHR23280:SF17
db: PANTHER Family
relationship type: By Homology

PTHR23280:SF12
type: RelationshipXref
id: PTHR23280:SF12
db: PANTHER Family
relationship type: By Homology

uniprot F1MF30 171
type: UnificationXref
id: F1MF30
db: uniprot

vesicle
type: CellularLocationVocabulary
xref: GO GO:0031982 2

EPB41L2 s66 sa78 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EPB41L2
stoichiometric coefficient: 1.0

SCL18A2/DOPA complex
type: Complex
component stoichiometry: SLC18A2 s229 sa84 STOICHIOMETRY ID COMPLEX
component stoichiometry: DOPA s84 sa83 STOICHIOMETRY ID COMPLEX
component: DOPA
component: SLC18A2
feature: COMPLEX BINDING FEATURE s230 csa14 281
feature: COMPLEX BINDING FEATURE s230 csa14 283
cellular location: synaptic vesicle

PTHR24353:SF82
type: RelationshipXref
id: PTHR24353:SF82
db: PANTHER Family
relationship type: By Homology

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

CHRNA6
type: Protein
entity reference: CHRNA6
feature: COMPLEX PARTICIPANT BINDING FEATURE s135 sa113 240
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re23 333
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

GNB
type: Protein
entity reference: GNB
feature: COMPLEX PARTICIPANT BINDING FEATURE s211 sa69 286
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re23 335
type: Stoichiometry
physical entity: SCL18A2/DOPA complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re23 334
type: Stoichiometry
physical entity: SLC18A2
stoichiometric coefficient: 1.0

PTHR11473:SF18
type: RelationshipXref
id: PTHR11473:SF18
db: PANTHER Family
relationship type: By Homology

uniprot F7CYH8 115
type: UnificationXref
id: F7CYH8
db: uniprot

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
type: ProteinReference
xref: PTHR11668:SF377
xref: uniprot Q3T0E7 111
organism: Bos taurus

STATE_TRANSITION_LEFT__ADCY2-RIGHT__ADCY2-_re14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 371
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 370
left: ADCY2
interaction type: STATE_TRANSITION
right: ADCY2

PRKACA
type: ProteinReference
xref: P06588
standard name: cAMP-dependent protein kinase catalytic subunit alpha
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.PRKACA
comment: ENTITY_REFERENCE_NOTES=
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha
member entity reference: Protein kinase cAMP-activated catalytic subunit alpha
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
member entity reference: Uncharacterized protein

DRD2/ DRD3/ DRD4
type: Protein
entity reference: DRD2/ DRD3/ DRD4
feature: COMPLEX PARTICIPANT BINDING FEATURE s192 sa71 224
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 378
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 379
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

KCNK3/9
type: Protein
entity reference: KCNK3/9
feature: KCNK3 9 s226 sa50 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re36 392
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re36 393
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re39
control type: ACTIVATION
controller: CHRNA4/CHRNB2/CHRNA6/CHRNB3 complex

GNG
type: Protein
entity reference: GNG
feature: COMPLEX PARTICIPANT BINDING FEATURE s212 sa61 314
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q6PH57 45
type: UnificationXref
id: Q6PH57
db: uniprot

DISSOCIATION
type: InteractionVocabulary

PTHR13809:SF52
type: RelationshipXref
id: PTHR13809:SF52
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9544 31
type: UnificationXref
id: 9544
db: ncbitaxon

STATE_TRANSITION_LEFT__CACNA-RIGHT__CACNA-_re6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 344
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 345
left: CACNA
interaction type: STATE_TRANSITION
right: CACNA

CHRNA4 s169 sa109 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA4
stoichiometric coefficient: 2.0

Serine/threonine-protein phosphatase (Fragment)
type: ProteinReference
xref: PTHR11668:SF300
xref: uniprot C3Z434 100
organism: Branchiostoma floridae

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 19

CHRNB2
type: ProteinReference
xref: P06613
standard name: Nicotinic acetylcholine receptor beta 2 subunit
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.RECEPTOR.CHRNB2
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Neuronal acetylcholine receptor subunit beta-2
member entity reference: Uncharacterized protein
member entity reference: CHRNB2 isoform 1

CHRNA5 s263 sa123 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA5
stoichiometric coefficient: 1.0

Gbeta Ggamma complex
type: Complex
component stoichiometry: GNB s211 sa69 STOICHIOMETRY ID COMPLEX
component stoichiometry: GNG s215 sa70 STOICHIOMETRY ID COMPLEX
component: GNB
component: GNG
feature: COMPLEX BINDING FEATURE s222 csa7 285
feature: COMPLEX BINDING FEATURE s222 csa7 287
cellular location: cytosol

uniprot Q9H4G0 80
type: UnificationXref
id: Q9H4G0
db: uniprot

uniprot P20420 52
type: UnificationXref
id: P20420
db: uniprot

GTP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7ASR8 30
type: UnificationXref
id: F7ASR8
db: uniprot

uniprot Q7ZVR3 112
type: UnificationXref
id: Q7ZVR3
db: uniprot

uniprot B2RSH2 155
type: UnificationXref
id: B2RSH2
db: uniprot

uniprot H2Q573 87
type: UnificationXref
id: H2Q573
db: uniprot

uniprot Q66II3 71
type: UnificationXref
id: Q66II3
db: uniprot

ADCY2
type: Protein
entity reference: ADCY2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q08462 142
type: UnificationXref
id: Q08462
db: uniprot

PARTICIPANT STOICHIOMETRY re21 342
type: Stoichiometry
physical entity: tyrosine
stoichiometric coefficient: 1.0

uniprot F1MC93 163
type: UnificationXref
id: F1MC93
db: uniprot

PARTICIPANT STOICHIOMETRY re21 343
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

FLNA
type: Protein
entity reference: FLNA
feature: COMPLEX PARTICIPANT BINDING FEATURE s70 sa80 250
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

EPB41L1
type: ProteinReference
xref: P06599
standard name: Erythrocyte membrane protein band 4.1-like 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.EPB41L1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Band 4.1-like protein 1
member entity reference: Erythrocyte membrane protein band 4.1 like 1

uniprot O88533 150
type: UnificationXref
id: O88533
db: uniprot

CHRNA4
type: Protein
entity reference: CHRNA4

CHRNB2
type: Protein
entity reference: CHRNB2

dopamine DRD2 DRD3 DRD4 G-protein complex
type: Complex
component stoichiometry: GNG s212 sa61 STOICHIOMETRY ID COMPLEX
component stoichiometry: DRD2 DRD3 DRD4 s190 sa57 STOICHIOMETRY ID COMPLEX
component stoichiometry: GNAI s218 sa59 STOICHIOMETRY ID COMPLEX
component stoichiometry: Dopamine s266 sa58 STOICHIOMETRY ID COMPLEX
component stoichiometry: GNB s208 sa60 STOICHIOMETRY ID COMPLEX
component: GNB
component: GNAI
component: Dopamine
component: GNG
component: DRD2/ DRD3/ DRD4
feature: COMPLEX BINDING FEATURE s202 csa4 313
feature: COMPLEX BINDING FEATURE s202 csa4 305
feature: COMPLEX BINDING FEATURE s202 csa4 307
feature: COMPLEX BINDING FEATURE s202 csa4 311
feature: COMPLEX BINDING FEATURE s202 csa4 309
cellular location: cytosol

CHRNA3/CHRNB4 complex
type: Complex
component stoichiometry: HOMODIMER ID 68STOICHIOMETRY ID COMPLEX
component: CHRNA3
component: CHRNB4
feature: COMPLEX BINDING FEATURE s146 csa2 271
feature: COMPLEX BINDING FEATURE s146 csa2 273
cellular location: cytosol

DRD2/ DRD3/ DRD4
type: ProteinReference
xref: P06603
standard name: Dopamine receptor D2/D3/D4
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.RECEPTOR.DRD2/_br_DRD3/_br_DRD4
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: D(2) dopamine receptor
member entity reference: D(4) dopamine receptor
member entity reference: D(3) dopamine receptor
member entity reference: Uncharacterized protein
member entity reference: Dopamine receptor D3

Band 4.1-like protein 1
type: ProteinReference
xref: uniprot Q9WTP0 81
xref: PTHR23280:SF24
organism: Rattus norvegicus

PPP1CA
type: Protein
entity reference: PPP1CA
feature: ACTIVE 24
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5QJI6 47
type: UnificationXref
id: A0A1D5QJI6
db: uniprot

PARTICIPANT STOICHIOMETRY re33 400
type: Stoichiometry
physical entity: GNAI
stoichiometric coefficient: 1.0

uniprot P62871 41
type: UnificationXref
id: P62871
db: uniprot

PARTICIPANT STOICHIOMETRY re33 402
type: Stoichiometry
physical entity: GNAI
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re33 401
type: Stoichiometry
physical entity: P
stoichiometric coefficient: 1.0

DRD2 DRD3 DRD4 CLIC6 complex
type: Complex
component stoichiometry: DRD2 DRD3 DRD4 s192 sa71 STOICHIOMETRY ID COMPLEX
component stoichiometry: CLIC6 s50 sa72 STOICHIOMETRY ID COMPLEX
component: DRD2/ DRD3/ DRD4
component: CLIC6
feature: COMPLEX BINDING FEATURE s198 csa8 225
feature: COMPLEX BINDING FEATURE s198 csa8 223
cellular location: cytosol

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G778 63
xref: PTHR18945:SF831
organism: Macaca mulatta

DRD2/ DRD3/ DRD4
type: Protein
entity reference: DRD2/ DRD3/ DRD4
feature: COMPLEX PARTICIPANT BINDING FEATURE s197 sa82 218
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q811Q2 169
type: UnificationXref
id: Q811Q2
db: uniprot

Voltage-dependent T-type calcium channel subunit alpha-1G
type: ProteinReference
xref: PTHR10037:SF137
xref: uniprot O54898 89
organism: Rattus norvegicus

uniprot Q01827 130
type: UnificationXref
id: Q01827
db: uniprot

PTHR45627:SF6
type: RelationshipXref
id: PTHR45627:SF6
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR11668:SF460
xref: uniprot Q7ZVR3 112
organism: Danio rerio

nicotine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa101 246
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

PPP1CA
type: Protein
entity reference: PPP1CA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7G4Q0 7
type: UnificationXref
id: F7G4Q0
db: uniprot

CHRNA4 CHRNB2 CHRNA6 CHRNB3 complex s172 csa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA4/CHRNB2/CHRNA6/CHRNB3 complex
stoichiometric coefficient: 1.0

CHRNA4/CHRNB2 complex
type: Complex
component stoichiometry: HOMODIMER ID 62STOICHIOMETRY ID COMPLEX
component: CHRNA4
component: CHRNB2
feature: COMPLEX PARTICIPANT BINDING FEATURE s168 csa20 294
feature: COMPLEX BINDING FEATURE s168 csa20 291
feature: ACTIVE 24
feature: COMPLEX BINDING FEATURE s168 csa20 289
cellular location: cytosol

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PPP1R1B-RIGHT__PPP1R1B-_re43
controller: PRKACA

uniprot F6UJE8 156
type: UnificationXref
id: F6UJE8
db: uniprot

D(4) dopamine receptor
type: ProteinReference
xref: uniprot P30729 121
xref: PTHR24247:SF205
organism: Rattus norvegicus

D(3) dopamine receptor
type: ProteinReference
xref: uniprot P30728 120
xref: PTHR24248:SF154
organism: Mus musculus

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 17

Neuronal acetylcholine receptor subunit alpha-5
type: ProteinReference
xref: PTHR18945:SF76
xref: uniprot Q8SPU7 57
organism: Bos taurus

GNAI
type: Protein
entity reference: GNAI
feature: COMPLEX PARTICIPANT BINDING FEATURE s218 sa59 310
feature: GNAI s218 sa59 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CHRNA4/CHRNB2/CHRNA6/CHRNB3 complex
type: Complex
component stoichiometry: CHRNA6 s175 sa104 STOICHIOMETRY ID COMPLEX
component stoichiometry: CHRNA4 s173 sa102 STOICHIOMETRY ID COMPLEX
component stoichiometry: CHRNB3 s176 sa105 STOICHIOMETRY ID COMPLEX
component: CHRNB3
component: CHRNB2
component: CHRNA4
component: CHRNA6
feature: COMPLEX BINDING FEATURE s171 csa18 251
feature: COMPLEX BINDING FEATURE s171 csa18 255
feature: COMPLEX BINDING FEATURE s171 csa18 257
feature: COMPLEX BINDING FEATURE s171 csa18 253
cellular location: cytosol

Voltage-dependent L-type calcium channel subunit alpha-1C
type: ProteinReference
xref: PTHR45628:SF10
xref: uniprot Q13936 90
organism: Homo sapiens

Cholinergic receptor nicotinic beta 3 subunit
type: ProteinReference
xref: PTHR18945:SF75
xref: uniprot F1PN73 172
organism: Canis lupus familiaris

nicotine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s115 sa94 296
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O54912 138
type: UnificationXref
id: O54912
db: uniprot

DRD2 DRD3 DRD4 s190 sa57 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DRD2/ DRD3/ DRD4
stoichiometric coefficient: 1.0

ADCY2
type: ProteinReference
xref: P06606
standard name: Adenylate cyclase 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.ADCY2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Adenylate cyclase type 2
member entity reference: Adenylate cyclase

PTHR10037:SF137
type: RelationshipXref
id: PTHR10037:SF137
db: PANTHER Family
relationship type: By Homology

uniprot P54311 40
type: UnificationXref
id: P54311
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__tyrosine-RIGHT__DOPA-_re21
controller: TH

GRB2
type: ProteinReference
xref: P06596
standard name: Growth factor receptor-bound protein 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.GRB2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Growth factor receptor-bound protein 2
member entity reference: Growth factor receptor-bound protein 2a

EPB41L1 s61 sa76 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EPB41L1
stoichiometric coefficient: 1.0

Neuronal acetylcholine receptor subunit alpha-3
type: ProteinReference
xref: uniprot Q07263 66
xref: PTHR18945:SF831
organism: Bos taurus

CDK5
type: ProteinReference
xref: P06597
standard name: Cyclin-dependent kinase 5
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.GENERIC.CDK5
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Uncharacterized protein

Nicotine pharmacodynamics pathway
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__DRD2__DRD3__DRD4-_EPB41L1-RIGHT__DRD2_DRD3_EPB41L1_complex-_re27
pathway component: KNOWN_TRANSITION_OMITTED
pathway component: STATE_TRANSITION_LEFT__PPP1R1B-RIGHT__PPP1R1B-_re45
pathway component: STATE_TRANSITION_LEFT__PPP1CA-RIGHT__PPP1CA-_re44
pathway component: STATE_TRANSITION_LEFT__CACNA-RIGHT__CACNA-_re6
pathway component: STATE_TRANSITION_LEFT__dopamine_DRD2_DRD3_DRD4_G_protein_complex-_GTP-RIGHT__dopamine_DRD2_DRD3_DRD4_complex-_GNAI-_GDP-_Gbeta_Ggamma_complex-_re42
pathway component: HETERODIMER_ASSOCIATION_LEFT__DRD2_DRD3_DRD4_G_protein_complex-_Dopamine-RIGHT__dopamine_DRD2_DRD3_DRD4_G_protein_complex-_re15
pathway component: STATE_TRANSITION_LEFT__PRKACA-RIGHT__PRKACA-_re13
pathway component: HETERODIMER_ASSOCIATION_LEFT__DOPA-_SLC18A2-RIGHT__SCL18A2_DOPA_complex-_re23
pathway component: STATE_TRANSITION_LEFT__GNAI-RIGHT__P-_GNAI-_re33
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re12
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re7
pathway component: STATE_TRANSITION_LEFT__DOPA-RIGHT__Dopamine-_re22
pathway component: HETERODIMER_ASSOCIATION_LEFT__DRD2__DRD3__DRD4-_EPB41L2-RIGHT__D3_EPB41L2_complex-_re28
pathway component: HETERODIMER_ASSOCIATION_LEFT__nicotine-_CHRNA4_CHRNB2_CHRNA6_CHRNB3_complex-RIGHT__nicotine_CHRNA4_CHRNB2_CHRNA6_CHRNB3_complex-_re49
pathway component: TRANSPORT_LEFT__epinephrine-RIGHT__epinephrine-_re8
pathway component: STATE_TRANSITION_LEFT__SNARE_complex-RIGHT__SNARE_complex-_re46
pathway component: HETERODIMER_ASSOCIATION_LEFT__DRD2__DRD3__DRD4-_EPB41-RIGHT__DRD2_DRD3_DRD4_EBP41_complex-_re26
pathway component: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re37
pathway component: STATE_TRANSITION_LEFT__ADCY2-RIGHT__ADCY2-_re14
pathway component: TRANSPORT_LEFT__Na_PLUS_-RIGHT__Na_PLUS_-_re2
pathway component: STATE_TRANSITION_LEFT__KCNK3_9-RIGHT__KCNK3_9-_re18
pathway component: HETERODIMER_ASSOCIATION_LEFT__nicotine-_CHRNA4_CHRNB2_CHRNA5_complex-RIGHT__nicotine_CHRNA4_CHRNB2_CHRNA5_complex-_re50
pathway component: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re19
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re39
pathway component: HETERODIMER_ASSOCIATION_LEFT__GRB2-_DRD2__DRD3__DRD4-RIGHT__DRD3_DRD4_GRB2_complex-_re30
pathway component: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re3
pathway component: HETERODIMER_ASSOCIATION_LEFT__GialphaGbetaGgamma_complex-_DRD2__DRD3__DRD4-RIGHT__DRD2_DRD3_DRD4_G_protein_complex-_re31
pathway component: HETERODIMER_ASSOCIATION_LEFT__nicotine-_CHRNA3_CHRNB4_complex-RIGHT__nicotine__CHRNA3_CHRNB4_complex-_re1
pathway component: HETERODIMER_ASSOCIATION_LEFT__CLIC6-_DRD2__DRD3__DRD4-RIGHT__DRD2_DRD3_DRD4_CLIC6_complex-_re25
pathway component: HETERODIMER_ASSOCIATION_LEFT__GNAI-_Gbeta_Ggamma_complex-RIGHT__GialphaGbetaGgamma_complex-_re34
pathway component: TRANSPORT_LEFT__Dopamine-RIGHT__Dopamine-_re17
pathway component: DISSOCIATION_LEFT__SCL18A2_DOPA_complex-RIGHT__SLC18A2-_DOPA-_re24
pathway component: TRANSPORT_LEFT__Na_PLUS_-RIGHT__Na_PLUS_-_re36
pathway component: HETERODIMER_ASSOCIATION_LEFT__nicotine-_CHRNA4_CHRNB2_complex-RIGHT__nicotine__CHRNA4_CHRNB2_complex-_re35
pathway component: HETERODIMER_ASSOCIATION_LEFT__DRD2__DRD3__DRD4-_FLNA-RIGHT__DRD2_DRD3_FLNA_complex-_re29
pathway component: STATE_TRANSITION_LEFT__tyrosine-RIGHT__DOPA-_re21
pathway component: STATE_TRANSITION_LEFT__PPP1R1B-RIGHT__PPP1R1B-_re43
xref: PANTHER Pathway P06587 1
comment: MODEL_NOTES=

HETERODIMER_ASSOCIATION_LEFT__DRD2__DRD3__DRD4-_EPB41-RIGHT__DRD2_DRD3_DRD4_EBP41_complex-_re26
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 324
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 326
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 325
left: EPB41
left: DRD2/ DRD3/ DRD4
interaction type: HETERODIMER_ASSOCIATION
right: DRD2/DRD3/DRD4 EBP41 complex

CHRNB3
type: Protein
entity reference: CHRNB3
feature: COMPLEX PARTICIPANT BINDING FEATURE s176 sa105 258
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

…
type: Stoichiometry
physical entity: CHRNB2
stoichiometric coefficient: 3.0

uniprot D3ZM69 73
type: UnificationXref
id: D3ZM69
db: uniprot

uniprot A0A2I3TP36 148
type: UnificationXref
id: A0A2I3TP36
db: uniprot

Band 4.1-like protein 1
type: ProteinReference
xref: PTHR23280:SF24
xref: uniprot Q9H4G0 80
organism: Homo sapiens

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

Thr75 PPP1R1B s243 sa120 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Thr75
feature location: Thr75 PPP1R1B s243 sa120 rs2 Thr75
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Thr75
comment: MODIFICATION_RESIDUE_ANGLE=5.045894450503827

K+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

Band 4.1-like protein 1
type: ProteinReference
xref: PTHR23280:SF24
xref: uniprot Q9Z2H5 82
organism: Mus musculus

CHRNB2 isoform 1
type: ProteinReference
xref: PTHR18945:SF80
xref: uniprot H2Q056 180
organism: Pan troglodytes

SLC18A2 s229 sa84 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SLC18A2
stoichiometric coefficient: 1.0

uniprot Q8SPU7 57
type: UnificationXref
id: Q8SPU7
db: uniprot

uniprot Q8MJ44 22
type: UnificationXref
id: Q8MJ44
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: uniprot F6ZAV4 141
xref: PTHR45627:SF6
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F7A472 157
organism: Xenopus tropicalis

CHRNA6 s175 sa104 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNA6
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G4Q0 7
xref: PTHR24353:SF82
organism: Monodelphis domestica

HETERODIMER_ASSOCIATION_LEFT__GNAI-_Gbeta_Ggamma_complex-RIGHT__GialphaGbetaGgamma_complex-_re34
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 399
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 398
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 397
left: GNAI
left: Gbeta Ggamma complex
interaction type: HETERODIMER_ASSOCIATION
right: GialphaGbetaGgamma complex

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re39
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 389
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 388
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

Uncharacterized protein
type: ProteinReference
xref: PTHR23506:SF30
xref: uniprot A0A1D5QT69 127
organism: Macaca mulatta

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: depolarization
controller: Ca2+

PTHR45628:SF15
type: RelationshipXref
id: PTHR45628:SF15
db: PANTHER Family
relationship type: By Homology

EPB41L2
type: Protein
entity reference: EPB41L2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR45628:SF10
type: RelationshipXref
id: PTHR45628:SF10
db: PANTHER Family
relationship type: By Homology

Tyrosine 3-monooxygenase
type: ProteinReference
xref: uniprot P07101 193
xref: PTHR11473:SF18
organism: Homo sapiens

CHRNB4
type: ProteinReference
xref: P06610
standard name: Nicotinic acetylcholine receptor beta 4 subunit
comment: ENTITY_REFERENCE_ID_DESC=Nicotine pharmacodynamics pathway.PROTEIN.RECEPTOR.CHRNB4
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Cholinergic receptor nicotinic beta 4 subunit
member entity reference: Neuronal acetylcholine receptor subunit beta-4

DOPA
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Protein phosphatase 1 regulatory subunit 1B
type: ProteinReference
xref: uniprot Q9UD71 27
xref: PTHR15417:SF2
organism: Homo sapiens

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 3

Thr75 PPP1R1B s241 sa115 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Thr75
feature location: Thr75 PPP1R1B s241 sa115 rs2 Thr75
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Thr75
comment: MODIFICATION_RESIDUE_ANGLE=5.045894450503827

PTHR45476:SF1
type: RelationshipXref
id: PTHR45476:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q5IS75 175
type: UnificationXref
id: Q5IS75
db: uniprot

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: increase heart rate
controller: epinephrine

D(2) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF87
xref: uniprot F1PMQ9 114
organism: Canis lupus familiaris

Dopamine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s266 sa58 308
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

TRANSPORT_LEFT__Na_PLUS_-RIGHT__Na_PLUS_-_re2
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 352
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 351
left: Na+
interaction type: TRANSPORT
right: Na+

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6VPY1 28
xref: PTHR13809:SF25
organism: Ornithorhynchus anatinus

CHRNB2 s167 sa91 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CHRNB2
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY re2 352
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 351
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0