Enhancer of split mgamma protein
type: DnaReference
xref: PTHR10985:SF12
organism: Drosophila melanogaster

PTHR24044:SF308
type: RelationshipXref
id: PTHR24044:SF308
db: PANTHER Family
relationship type: By Homology

Enhancer of split mdelta protein
type: DnaReference
xref: PTHR10985:SF12
organism: Drosophila melanogaster

Enhancer of split mbeta protein
type: DnaReference
xref: PTHR10985:SF12
organism: Drosophila melanogaster

PTHR24044:SF438
type: RelationshipXref
id: PTHR24044:SF438
db: PANTHER Family
relationship type: By Homology

uniprot Q10741 115
type: UnificationXref
id: Q10741
db: uniprot

LNXp80
type: Protein
entity reference: LNXp80
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9UM47 40
type: UnificationXref
id: Q9UM47
db: uniprot

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 2

PARTICIPANT STOICHIOMETRY r26 271
type: Stoichiometry
physical entity: Numb
stoichiometric coefficient: 1.0

Hes related family bHLH transcription factor with YRPW motif 2
type: DnaReference
organism: Pan troglodytes

Protein numb homolog
type: ProteinReference
xref: PTHR11232:SF33
xref: uniprot Q9QZS3 232
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r26 272
type: Stoichiometry
physical entity: a25_degraded
stoichiometric coefficient: 1.0

Beta-1,3-N-acetylglucosaminyltransferase
type: ProteinReference
xref: uniprot F6UP69 125
organism: Xenopus tropicalis

TRANSPORT_LEFT__NIcs-RIGHT__NIcs-_r10
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 296
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 295
left: NIcs
interaction type: TRANSPORT
right: NIcs

uniprot Q8WZM0 47
type: UnificationXref
id: Q8WZM0
db: uniprot

Alpha-(1,6)-fucosyltransferase
type: ProteinReference
xref: uniprot F1PZQ9 179
organism: Canis lupus familiaris

uniprot Q24342 131
type: UnificationXref
id: Q24342
db: uniprot

uniprot D4A198 216
type: UnificationXref
id: D4A198
db: uniprot

Nuclear receptor corepressor 2
type: ProteinReference
xref: PTHR13992:SF21
xref: uniprot F1PQQ7 167
organism: Canis lupus familiaris

uniprot F1PU73 136
type: UnificationXref
id: F1PU73
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR10985:SF136
organism: Macaca mulatta

Pen2
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa15 235
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6XAH5 180
type: UnificationXref
id: F6XAH5
db: uniprot

PTHR45750:SF3
type: RelationshipXref
id: PTHR45750:SF3
db: PANTHER Family
relationship type: By Homology

Ntm
type: ProteinReference
xref: P01114
standard name: Notch transmembrane domain fragment
comment: ENTITY_REFERENCE_NOTES= Long Name: Notch transmembrane domain fragment Synonym: Synonym not specified Accession: P01114
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.TRUNCATED.N_sub_tm
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
member entity reference: Neurogenic locus notch homolog protein 2
member entity reference: Neurogenic locus notch homolog protein 4
member entity reference: Notch 4
member entity reference: NOTCH3 isoform 1
member entity reference: Neurogenic locus notch homolog protein 3
member entity reference: Uncharacterized protein
member entity reference: Neurogenic locus notch homolog protein 1
member entity reference: Protein glp-1
member entity reference: Notch 3
member entity reference: Notch 1
member entity reference: NOTCH1 isoform 1
member entity reference: Protein lin-12

uniprot F6UP69 125
type: UnificationXref
id: F6UP69
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 21

STATE_TRANSITION_LEFT__fucose-_Notch-RIGHT__Notch-_r18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 281
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 279
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 280
left: Notch
left: fucose
interaction type: STATE_TRANSITION
right: Notch

uniprot Q9UUK2 49
type: UnificationXref
id: Q9UUK2
db: uniprot

Neurogenic locus notch homolog protein 4
type: ProteinReference
xref: uniprot P31695 27
xref: PTHR24044:SF470
organism: Mus musculus

ADAM metallopeptidase domain 17
type: ProteinReference
xref: PTHR45702:SF6
xref: uniprot E1B867 105
organism: Bos taurus

PTHR24044:SF421
type: RelationshipXref
id: PTHR24044:SF421
db: PANTHER Family
relationship type: By Homology

PTHR24044:SF415
type: RelationshipXref
id: PTHR24044:SF415
db: PANTHER Family
relationship type: By Homology

PTHR24044:SF417
type: RelationshipXref
id: PTHR24044:SF417
db: PANTHER Family
relationship type: By Homology

Neurogenic locus notch homolog protein 2
type: ProteinReference
xref: PTHR45836:SF15
xref: uniprot Q04721 30
organism: Homo sapiens

uniprot E1BPT8 10
type: UnificationXref
id: E1BPT8
db: uniprot

LNXp80
type: ProteinReference
xref: P01111
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.GENERIC.LNXp80
comment: ENTITY_REFERENCE_NOTES= Long Name: LNXp80 Synonym: Ligand of Numb-protein X 80 kDa Accession: P01111
member entity reference: E3 ubiquitin-protein ligase LNX
member entity reference: Ligand of Numb protein X 2
member entity reference: LNX2 isoform 1
member entity reference: LNX1 isoform 2
member entity reference: Ligand of numb-protein X 1

uniprot Q9Z1K9 118
type: UnificationXref
id: Q9Z1K9
db: uniprot

Hairy/enhancer-of-split related with YRPW motif-like (Predicted)
type: DnaReference
xref: PTHR10985:SF79
organism: Rattus norvegicus

HEY1 isoform 1
type: DnaReference
organism: Pan troglodytes

Protein lin-12
type: ProteinReference
xref: uniprot P14585 25
xref: PTHR24044:SF417
organism: Caenorhabditis elegans

uniprot O88671 202
type: UnificationXref
id: O88671
db: uniprot

PTHR10811:SF1
type: RelationshipXref
id: PTHR10811:SF1
db: PANTHER Family
relationship type: By Homology

PTHR10985:SF19
type: RelationshipXref
id: PTHR10985:SF19
db: PANTHER Family
relationship type: By Homology

Delta-like protein 1
type: ProteinReference
xref: PTHR24044:SF380
xref: uniprot P97677 205
organism: Rattus norvegicus

PTHR10811:SF6
type: RelationshipXref
id: PTHR10811:SF6
db: PANTHER Family
relationship type: By Homology

PTHR10811:SF7
type: RelationshipXref
id: PTHR10811:SF7
db: PANTHER Family
relationship type: By Homology

uniprot P31695 27
type: UnificationXref
id: P31695
db: uniprot

ADAM metallopeptidase domain 10
type: ProteinReference
xref: uniprot F7EK00 108
organism: Ornithorhynchus anatinus

Su(H)
type: Protein
entity reference: Su(H)
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa6 266
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot G3V725 126
type: UnificationXref
id: G3V725
db: uniprot

PTHR19964:SF14
type: RelationshipXref
id: PTHR19964:SF14
db: PANTHER Family
relationship type: By Homology

uniprot Q61483 208
type: UnificationXref
id: Q61483
db: uniprot

uniprot F6YF14 145
type: UnificationXref
id: F6YF14
db: uniprot

uniprot G7ME71 137
type: UnificationXref
id: G7ME71
db: uniprot

PARTICIPANT STOICHIOMETRY r8 304
type: Stoichiometry
physical entity: NIcs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 303
type: Stoichiometry
physical entity: Ntm
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 302
type: Stoichiometry
physical entity: NIct
stoichiometric coefficient: 1.0

uniprot Q9Z0F8 117
type: UnificationXref
id: Q9Z0F8
db: uniprot

Disintegrin and metalloproteinase domain-containing protein 17
type: ProteinReference
xref: PTHR45702:SF6
xref: uniprot Q9Z1K9 118
organism: Rattus norvegicus

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 17

uniprot Q92585 121
type: UnificationXref
id: Q92585
db: uniprot

Notch 3
type: ProteinReference
xref: PTHR24033:SF176
xref: uniprot E1BPT8 10
organism: Bos taurus

Neurogenic locus notch homolog protein 1
type: ProteinReference
xref: PTHR45836:SF12
xref: uniprot P46531 28
organism: Homo sapiens

Delta-like protein 3
type: ProteinReference
xref: uniprot O88671 202
xref: PTHR24044:SF308
organism: Rattus norvegicus

uniprot Q93794 82
type: UnificationXref
id: Q93794
db: uniprot

Neurogenic locus notch homolog protein 2
type: ProteinReference
xref: uniprot Q9QW30 38
xref: PTHR22804:SF52
organism: Rattus norvegicus

uniprot Q90Y57 100
type: UnificationXref
id: Q90Y57
db: uniprot

uniprot P80370 204
type: UnificationXref
id: P80370
db: uniprot

uniprot F6UX21 225
type: UnificationXref
id: F6UX21
db: uniprot

STATE_TRANSITION_LEFT__NIcs-_Ub-RIGHT__NIcs-_r16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 284
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 286
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 285
left: Ub
left: NIcs
interaction type: STATE_TRANSITION
right: NIcs

PTHR10985:SF79
type: RelationshipXref
id: PTHR10985:SF79
db: PANTHER Family
relationship type: By Homology

Neuralized-like protein 2
type: ProteinReference
xref: uniprot Q9D0S4 222
organism: Mus musculus

uniprot H2RDK4 19
type: UnificationXref
id: H2RDK4
db: uniprot

ncbitaxon 3702 142
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot O70263 161
type: UnificationXref
id: O70263
db: uniprot

uniprot F7G756 197
type: UnificationXref
id: F7G756
db: uniprot

uniprot H2R900 110
type: UnificationXref
id: H2R900
db: uniprot

Aph1 s33 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Aph1
stoichiometric coefficient: 1.0

uniprot H2QJZ0 95
type: UnificationXref
id: H2QJZ0
db: uniprot

Presenilin
type: ProteinReference
xref: P01110
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.GENERIC.Presenilin
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Presenilin-1
member entity reference: Presenilin
member entity reference: Presenilin sel-12
member entity reference: Presenilin homolog
member entity reference: Presenilin hop-1

uniprot K7AK75 170
type: UnificationXref
id: K7AK75
db: uniprot

ncbitaxon 6239 23
type: UnificationXref
id: 6239
db: ncbitaxon

E(spl)-C genes
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

PTHR45702:SF6
type: RelationshipXref
id: PTHR45702:SF6
db: PANTHER Family
relationship type: By Homology

uniprot A0A3Q2UCS9 56
type: UnificationXref
id: A0A3Q2UCS9
db: uniprot

uniprot O00587 127
type: UnificationXref
id: O00587
db: uniprot

uniprot H2RDH4 199
type: UnificationXref
id: H2RDH4
db: uniprot

PTHR10985:SF78
type: RelationshipXref
id: PTHR10985:SF78
db: PANTHER Family
relationship type: By Homology

uniprot F7ENN2 94
type: UnificationXref
id: F7ENN2
db: uniprot

Uncharacterized protein
type: DnaReference
organism: Macaca mulatta

LNX1 isoform 2
type: ProteinReference
xref: uniprot H2QPH1 160
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Delta-_Notch-RIGHT__Complex__Notch_Delta_-_r28
controller: Fringe

uniprot Q8TBB1 163
type: UnificationXref
id: Q8TBB1
db: uniprot

Transcription factor HES-2
type: DnaReference
organism: Mus musculus

uniprot Q8CGU6 140
type: UnificationXref
id: Q8CGU6
db: uniprot

Uncharacterized protein
type: DnaReference
organism: Macaca mulatta

ncbitaxon 284591 48
type: UnificationXref
id: 284591
db: ncbitaxon

Numb
type: Protein
entity reference: Numb
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Notch signaling pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__NIcs-_Ub-RIGHT__NIcs-_r16
pathway component: STATE_TRANSITION_LEFT__NIcs-RIGHT__a46_degraded-_r17
pathway component: TRUNCATION_LEFT__Complex__Serrate_Notch_-RIGHT__Complex__Serrate_Next_-_NIct-_r25
pathway component: HETERODIMER_ASSOCIATION_LEFT__Notch-_Serrate-RIGHT__Complex__Serrate_Notch_-_r21
pathway component: HETERODIMER_ASSOCIATION_LEFT__Delta-_Notch-RIGHT__Complex__Notch_Delta_-_r28
pathway component: TRANSCRIPTION_LEFT__E_spl__C_genes-RIGHT__E_spl__C_genes-_re16
pathway component: DISSOCIATION_LEFT__Complex__Su_H__CoR_-RIGHT__Su_H_-_CoR-_r11
pathway component: STATE_TRANSITION_LEFT__Numb-RIGHT__a25_degraded-_r26
pathway component: HETERODIMER_ASSOCIATION_LEFT__CoA-_NIcs-_Su_H_-_Mastermind-RIGHT__Complex__Mastermind_Su_H___CoA_NIcs_-_r13
pathway component: TRUNCATION_LEFT__NIct-RIGHT__Ntm-_NIcs-_r8
pathway component: STATE_TRANSITION_LEFT__Delta-RIGHT__a7_degraded-_r9
pathway component: STATE_TRANSITION_LEFT__fucose-_Notch-RIGHT__Notch-_r18
pathway component: TRANSPORT_LEFT__NIcs-RIGHT__NIcs-_r10
pathway component: TRUNCATION_LEFT__Complex__Notch_Delta_-RIGHT__Complex__Delta_Next_-_NIct-_r29
xref: PANTHER Pathway P00045 1
comment: MODEL_NOTES=Panther Pathway: P00045 Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade. It plays a key role in modulating cell fate decisions throughout the development of invertebrate and vertebrate species. A number of human diseases have been associated with mistakes of Notch function. Medline=11112321 Medline=12366684 Medline=12651094 Medline=12676578 Medline=14973298 PMID: 11112321 PMID: 12366684 PMID: 12651094 PMID: 12676578 PMID: 14973298

ncbitaxon 13616 65
type: UnificationXref
id: 13616
db: ncbitaxon

Nuclear receptor corepressor 2
type: ProteinReference
xref: uniprot Q9Y618 177
xref: PTHR13992:SF21
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5F3N4 116
organism: Gallus gallus

PTHR19848:SF4
type: RelationshipXref
id: PTHR19848:SF4
db: PANTHER Family
relationship type: By Homology

uniprot O09009 129
type: UnificationXref
id: O09009
db: uniprot

Alpha-(1,6)-fucosyltransferase
type: ProteinReference
xref: uniprot F1N4H9 178
organism: Bos taurus

uniprot F7GDI5 198
type: UnificationXref
id: F7GDI5
db: uniprot

PTHR24049:SF18
type: RelationshipXref
id: PTHR24049:SF18
db: PANTHER Family
relationship type: By Homology

Next s12 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Next
stoichiometric coefficient: 1.0

Presenilin-1
type: ProteinReference
xref: PTHR10202:SF18
xref: uniprot P49768 150
organism: Homo sapiens

NIcs
type: Protein
entity reference: NIcs
feature: NIcs s63 a16 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Presenilin-1
type: ProteinReference
xref: uniprot P49769 151
xref: PTHR10202:SF18
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GRS2 168
xref: PTHR13151:SF2
organism: Macaca mulatta

Ligand of numb-protein X 1
type: ProteinReference
xref: PTHR19964:SF14
xref: uniprot B6RHI6 158
organism: Rattus norvegicus

Su H s8 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Su(H)
stoichiometric coefficient: 1.0

Delta
type: ProteinReference
xref: P01116
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.GENERIC.Delta
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Delta Synonym: Delta-like1,Delta-like3,Delta-like4,DeltaC,LAG-2 Accession: P01116
member entity reference: Delta-like protein D
member entity reference: Uncharacterized protein
member entity reference: Protein delta homolog 1
member entity reference: DLL3 isoform 4
member entity reference: Delta-like protein
member entity reference: DLK1 isoform 1
member entity reference: Delta-like protein 4
member entity reference: Neurogenic locus protein delta
member entity reference: Delta-like protein 1
member entity reference: Delta-like protein 3

PARTICIPANT STOICHIOMETRY r21 278
type: Stoichiometry
physical entity: Complex (Serrate/Notch)
stoichiometric coefficient: 1.0

Hairy-related 6
type: DnaReference
xref: PTHR10985:SF19
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r21 277
type: Stoichiometry
physical entity: Serrate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r21 276
type: Stoichiometry
physical entity: Notch
stoichiometric coefficient: 1.0

uniprot F7BVV0 181
type: UnificationXref
id: F7BVV0
db: uniprot

Nicastrin s34 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Nicastrin
stoichiometric coefficient: 1.0

uniprot Q0V7L8 207
type: UnificationXref
id: Q0V7L8
db: uniprot

LNX2 isoform 1
type: ProteinReference
xref: uniprot H2Q7C2 159
organism: Pan troglodytes

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 5

Histone acetyltransferase gcn5
type: ProteinReference
xref: uniprot Q9UUK2 49
xref: PTHR45750:SF3
organism: Schizosaccharomyces pombe

NIcs
type: ProteinReference
xref: P01120
standard name: Notch intracellular soluble fragment
comment: ENTITY_REFERENCE_NOTES= Long Name: Notch intracellular soluble fragment Synonym: Synonym not specified Accession: P01120
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.TRUNCATED.NI_sub_c_sub_s
member entity reference: Neurogenic locus notch homolog protein 2
member entity reference: Neurogenic locus notch homolog protein 4
member entity reference: Notch 4
member entity reference: NOTCH3 isoform 1
member entity reference: Neurogenic locus notch homolog protein 3
member entity reference: Uncharacterized protein
member entity reference: Neurogenic locus notch homolog protein 1
member entity reference: Protein glp-1
member entity reference: Notch 3
member entity reference: Notch 1
member entity reference: NOTCH1 isoform 1
member entity reference: Protein lin-12

Transcription factor HES-1
type: DnaReference
xref: PTHR10985:SF19
organism: Xenopus tropicalis

Notch
type: ProteinReference
xref: P01099
comment: ENTITY_REFERENCE_NOTES= Long Name: Notch Synonym: GLP-1,LIN-12,Notch1,Notch2,Notch3,Notch4 Accession: P01099
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.RECEPTOR.Notch
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Neurogenic locus notch homolog protein 2
member entity reference: Neurogenic locus notch homolog protein 4
member entity reference: Notch 4
member entity reference: NOTCH3 isoform 1
member entity reference: Neurogenic locus notch homolog protein 3
member entity reference: Uncharacterized protein
member entity reference: Neurogenic locus notch homolog protein 1
member entity reference: Protein glp-1
member entity reference: Notch 3
member entity reference: Notch 1
member entity reference: NOTCH1 isoform 1
member entity reference: Protein lin-12

Serrate s13 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Serrate
stoichiometric coefficient: 1.0

uniprot A0A1D5R3Z3 53
type: UnificationXref
id: A0A1D5R3Z3
db: uniprot

E3 ubiquitin-protein ligase LNX
type: ProteinReference
xref: PTHR19964:SF14
xref: uniprot O70263 161
organism: Mus musculus

uniprot Q07008 31
type: UnificationXref
id: Q07008
db: uniprot

Notch s14 sa10 rs1
type: ModificationFeature
modification type: MODIFICATION FEATURE unknown
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.6087487659704043
comment: MODIFICATION_RESIDUE_NAME=

ncbitaxon 9606 29
type: UnificationXref
id: 9606
db: ncbitaxon

Recombining binding protein suppressor of hairless
type: ProteinReference
xref: uniprot Q3SZ41 76
xref: PTHR10665:SF3
organism: Bos taurus

Corepressor interacting with RBPJ, 1
type: ProteinReference
xref: PTHR13151:SF2
xref: uniprot K7AK75 170
organism: Pan troglodytes

CoA
type: Protein
entity reference: CoA
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q9Y219 104
type: UnificationXref
id: Q9Y219
db: uniprot

Hairy/enhancer-of-split related with YRPW motif protein 1
type: DnaReference
organism: Canis lupus familiaris

a46_degraded
type: PhysicalEntity
cellular location: nucleus
comment: SPECIES_TYPE=DEGRADED

Delta-like protein
type: ProteinReference
xref: uniprot E1BDN7 86
xref: PTHR24044:SF448
organism: Bos taurus

uniprot H2Q7C2 159
type: UnificationXref
id: H2Q7C2
db: uniprot

Neuralized-like protein 4
type: ProteinReference
xref: uniprot Q96JN8 220
organism: Homo sapiens

uniprot P16554 229
type: UnificationXref
id: P16554
db: uniprot

DISSOCIATION
type: RelationshipTypeVocabulary

Complex (Pen2/Aph1/ Nicastrin/Presenilin)
type: Complex
component stoichiometry: Pen2 s31 sa15 STOICHIOMETRY ID COMPLEX
component stoichiometry: Nicastrin s34 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: Aph1 s33 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: Presenilin s36 sa18 STOICHIOMETRY ID COMPLEX
component: Nicastrin
component: Aph1
component: Presenilin
component: Pen2
feature: COMPLEX BINDING FEATURE s74 a84 238
feature: COMPLEX BINDING FEATURE s74 a84 240
feature: COMPLEX BINDING FEATURE s74 a84 234
feature: COMPLEX BINDING FEATURE s74 a84 236
cellular location: cytosol

Uncharacterized protein
type: ProteinReference
xref: PTHR13151:SF2
xref: uniprot Q9VVU4 175
organism: Drosophila melanogaster

Notch 1
type: ProteinReference
xref: PTHR24033:SF176
xref: uniprot F1PDC7 11
organism: Canis lupus familiaris

uniprot A0A096MJM7 213
type: UnificationXref
id: A0A096MJM7
db: uniprot

uniprot F7EK00 108
type: UnificationXref
id: F7EK00
db: uniprot

uniprot Q5U2T8 171
type: UnificationXref
id: Q5U2T8
db: uniprot

Neurogenic locus notch homolog protein 2
type: ProteinReference
xref: uniprot O35516 20
xref: PTHR22804:SF52
organism: Mus musculus

Beta-1,3-N-acetylglucosaminyltransferase
type: ProteinReference
xref: PTHR10811:SF7
xref: uniprot A0A2I3T005 123
organism: Pan troglodytes

Mastermind
type: Protein
entity reference: Mastermind
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa5 264
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

HES2 isoform 2
type: DnaReference
organism: Pan troglodytes

PTHR10985:SF12
type: RelationshipXref
id: PTHR10985:SF12
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r9 298
type: Stoichiometry
physical entity: a7_degraded
stoichiometric coefficient: 1.0

uniprot H9EQI5 111
type: UnificationXref
id: H9EQI5
db: uniprot

PARTICIPANT STOICHIOMETRY r9 297
type: Stoichiometry
physical entity: Delta
stoichiometric coefficient: 1.0

uniprot O08674 69
type: UnificationXref
id: O08674
db: uniprot

uniprot P31266 73
type: UnificationXref
id: P31266
db: uniprot

ncbitaxon 9598 17
type: UnificationXref
id: 9598
db: ncbitaxon

Delta
type: Protein
entity reference: Delta
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION
type: RelationshipTypeVocabulary

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Delta-RIGHT__a7_degraded-_r9
controller: Neuralized

uniprot Q9H488 190
type: UnificationXref
id: Q9H488
db: uniprot

Recombination signal-binding protein for immunoglobulin kappa J region
type: ProteinReference
xref: PTHR10665:SF3
xref: uniprot M0R7Q3 68
organism: Rattus norvegicus

Nicastrin
type: ProteinReference
xref: uniprot Q23316 139
xref: PTHR21092:SF0
organism: Caenorhabditis elegans

uniprot Q338B9 43
type: UnificationXref
id: Q338B9
db: uniprot

F-box/WD repeat-containing protein sel-10
type: ProteinReference
xref: PTHR19848:SF4
xref: uniprot Q93794 82
organism: Caenorhabditis elegans

Corepressor interacting with RBPJ 1
type: ProteinReference
xref: PTHR13151:SF2
xref: uniprot Q9DA19 174
organism: Mus musculus

E(spl)-C genes
type: DnaRegion
entity reference: Enhancer of Split complex genes
cellular location: nucleus
comment: SPECIES_TYPE=GENE

NIcs s10 sa8 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY
feature location: NIcs s10 sa8 rs1
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Mastermind s6 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Mastermind
stoichiometric coefficient: 1.0

Nicastrin
type: ProteinReference
xref: uniprot Q8CGU6 140
xref: PTHR21092:SF0
organism: Rattus norvegicus

Hairy/enhancer-of-split related with YRPW motif protein 1
type: DnaReference
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r10 296
type: Stoichiometry
physical entity: NIcs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 295
type: Stoichiometry
physical entity: NIcs
stoichiometric coefficient: 1.0

ACTIVE 246
type: EntityFeature
comment: Active state

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
type: ProteinReference
xref: uniprot G3V725 126
xref: PTHR10811:SF6
organism: Rattus norvegicus

G01541
type: UnificationXref
id: G01541
db: PANTHER Pathway Component

uniprot E1BTW5 87
type: UnificationXref
id: E1BTW5
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 23

uniprot O14672 112
type: UnificationXref
id: O14672
db: uniprot

Notch 4
type: ProteinReference
xref: uniprot Q6MG89 36
xref: PTHR24044:SF470
organism: Rattus norvegicus

uniprot Q9UBG7 77
type: UnificationXref
id: Q9UBG7
db: uniprot

uniprot A0A2I3RGF5 192
type: UnificationXref
id: A0A2I3RGF5
db: uniprot

Hairy/enhancer-of-split related with YRPW motif protein 1
type: DnaReference
xref: PTHR10985:SF78
organism: Xenopus tropicalis

uniprot F6TFV4 196
type: UnificationXref
id: F6TFV4
db: uniprot

Neuralized
type: Protein
entity reference: Neuralized
comment: SPECIES_TYPE=PROTEIN

Notch s20 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Notch
stoichiometric coefficient: 1.0

ADAM metallopeptidase domain 10
type: ProteinReference
xref: uniprot H2Q9I4 109
organism: Pan troglodytes

ncbitaxon 10090 21
type: UnificationXref
id: 10090
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HIR8 182
organism: Macaca mulatta

Su H s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Su(H)
stoichiometric coefficient: 1.0

Protein numb homolog
type: ProteinReference
xref: uniprot P49757 230
xref: PTHR11232:SF33
organism: Homo sapiens

uniprot P97887 153
type: UnificationXref
id: P97887
db: uniprot

Delta-like protein
type: ProteinReference
xref: uniprot E2R9U3 195
xref: PTHR24044:SF320
organism: Canis lupus familiaris

Neurotic
type: ProteinReference
xref: P01115
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Neurotic Synonym: O-fucosyltransferase 1,O-fut1,OFUT1,Ofut1 Accession: P01115
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.GENERIC.Neurotic
member entity reference: Alpha-(1,6)-fucosyltransferase
member entity reference: Uncharacterized protein
member entity reference: GDP-fucose protein O-fucosyltransferase 1

Beta-1,3-N-acetylglucosaminyltransferase manic fringe
type: ProteinReference
xref: uniprot O00587 127
organism: Homo sapiens

PTHR24033:SF188
type: RelationshipXref
id: PTHR24033:SF188
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR11232:SF33
xref: uniprot F6WLR7 226
organism: Macaca mulatta

uniprot D3ZXN9 166
type: UnificationXref
id: D3ZXN9
db: uniprot

Nicastrin
type: ProteinReference
xref: PTHR21092:SF0
xref: uniprot Q92542 143
organism: Homo sapiens

uniprot H2RC16 120
type: UnificationXref
id: H2RC16
db: uniprot

NIcs
type: Protein
entity reference: NIcs
feature: NIcs s24 a24 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2J8NVW7 55
type: UnificationXref
id: A0A2J8NVW7
db: uniprot

Presenilin-1
type: ProteinReference
xref: uniprot Q4JIM4 154
xref: PTHR10202:SF18
organism: Gallus gallus

TRANSPORT
type: RelationshipTypeVocabulary

Su(H)
type: Protein
entity reference: Su(H)
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 7719 71
type: UnificationXref
id: 7719
db: ncbitaxon

Delta-like protein
type: ProteinReference
xref: uniprot F6VUQ4 91
xref: PTHR24044:SF448
organism: Ornithorhynchus anatinus

Nuclear receptor co-repressor 2
type: ProteinReference
xref: PTHR13992:SF21
xref: uniprot D3ZXN9 166
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR47368:SF3
xref: uniprot E1B8G1 224
organism: Bos taurus

Neurogenic locus protein delta
type: ProteinReference
xref: PTHR24044:SF438
xref: uniprot P10041 203
organism: Drosophila melanogaster

PTHR24033:SF176
type: RelationshipXref
id: PTHR24033:SF176
db: PANTHER Family
relationship type: By Homology

Delta-like protein
type: ProteinReference
xref: uniprot F7BUF3 92
organism: Macaca mulatta

Next s17 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Next
stoichiometric coefficient: 1.0

uniprot E1BDN7 86
type: UnificationXref
id: E1BDN7
db: uniprot

Lin-12 And Glp-1 phenotype
type: ProteinReference
xref: uniprot V6CLJ5 78
xref: PTHR10665:SF0
organism: Caenorhabditis elegans

NOTCH1 isoform 1
type: ProteinReference
xref: uniprot H2QY65 18
xref: PTHR45836:SF12
organism: Pan troglodytes

Transcription factor HES-5
type: DnaReference
xref: PTHR10985:SF104
organism: Homo sapiens

Histone acetyltransferase GCN5
type: ProteinReference
xref: uniprot Q03330 41
xref: PTHR45750:SF3
organism: Saccharomyces cerevisiae

NIct
type: Protein
entity reference: NIct
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot O35516 20
type: UnificationXref
id: O35516
db: uniprot

ncbitaxon 10116 32
type: UnificationXref
id: 10116
db: ncbitaxon

Hairy/enhancer-of-split related with YRPW motif 2
type: DnaReference
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__NIcs-RIGHT__a46_degraded-_r17
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 282
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 283
left: NIcs
interaction type: STATE_TRANSITION
right: a46_degraded

Nicastrin
type: ProteinReference
xref: uniprot G7ME71 137
xref: PTHR21092:SF0
organism: Macaca mulatta

uniprot E2R9U3 195
type: UnificationXref
id: E2R9U3
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

uniprot F1P9A0 124
type: UnificationXref
id: F1P9A0
db: uniprot

Neurogenic locus notch homolog protein 3
type: ProteinReference
xref: PTHR45836:SF17
xref: uniprot Q9UM47 40
organism: Homo sapiens

uniprot H2Q9I4 109
type: UnificationXref
id: H2Q9I4
db: uniprot

Nicastrin
type: ProteinReference
xref: uniprot A0A2I3TWA0 135
xref: PTHR21092:SF0
organism: Pan troglodytes

uniprot F7HIR8 182
type: UnificationXref
id: F7HIR8
db: uniprot

PARTICIPANT STOICHIOMETRY r11 293
type: Stoichiometry
physical entity: Su(H)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 292
type: Stoichiometry
physical entity: Complex (Su(H)/CoR)
stoichiometric coefficient: 1.0

ncbitaxon 8364 67
type: UnificationXref
id: 8364
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR45836:SF12
xref: uniprot F7H8I5 15
organism: Macaca mulatta

Disintegrin and metalloproteinase domain-containing protein 10
type: ProteinReference
xref: uniprot O35598 113
organism: Mus musculus

Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
type: ProteinReference
xref: uniprot Q8NES3 133
organism: Homo sapiens

Sel 10
type: Protein
entity reference: Sel 10
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 65

STATE_TRANSITION_LEFT__Numb-RIGHT__a25_degraded-_r26
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 271
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 272
left: Numb
interaction type: STATE_TRANSITION
right: a25_degraded

uniprot F1NMD6 90
type: UnificationXref
id: F1NMD6
db: uniprot

PTHR24033:SF194
type: RelationshipXref
id: PTHR24033:SF194
db: PANTHER Family
relationship type: By Homology

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 71

G protein pathway suppressor 2 (Predicted)
type: ProteinReference
xref: uniprot D4A198 216
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR24033:SF188
xref: uniprot A0A3Q1MTU2 8
organism: Bos taurus

ADAM metallopeptidase domain 17
type: ProteinReference
xref: uniprot H2R900 110
xref: PTHR45702:SF6
organism: Pan troglodytes

uniprot Q9QXX0 101
type: UnificationXref
id: Q9QXX0
db: uniprot

IEP
type: EvidenceCodeVocabulary
xref: eco ECO:0000270 33

Mastermind-like protein 1
type: ProteinReference
xref: uniprot Q92585 121
xref: PTHR15692:SF19
organism: Homo sapiens

uniprot F1PDC7 11
type: UnificationXref
id: F1PDC7
db: uniprot

Delta-like protein
type: ProteinReference
xref: uniprot E1BTW5 87
xref: PTHR24044:SF448
organism: Gallus gallus

uniprot F7BXC9 66
type: UnificationXref
id: F7BXC9
db: uniprot

Hairy/enhancer-of-split related with YRPW motif protein 2
type: DnaReference
organism: Mus musculus

TRANSCRIPTION
type: InteractionVocabulary

Uncharacterized protein
type: ProteinReference
xref: PTHR13992:SF21
xref: uniprot A0A1D5RHE4 165
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r11 294
type: Stoichiometry
physical entity: CoR
stoichiometric coefficient: 1.0

Histone acetyltransferase GCN5
type: ProteinReference
xref: PTHR45750:SF3
xref: uniprot Q338B9 43
organism: Oryza sativa

Hairy/enhancer-of-split related with YRPW motif-like protein
type: DnaReference
xref: PTHR10985:SF79
organism: Macaca mulatta

uniprot F7AGU8 146
type: UnificationXref
id: F7AGU8
db: uniprot

PTHR10985:SF137
type: RelationshipXref
id: PTHR10985:SF137
db: PANTHER Family
relationship type: By Homology

PTHR10985:SF136
type: RelationshipXref
id: PTHR10985:SF136
db: PANTHER Family
relationship type: By Homology

Ligand of Numb protein X 2
type: ProteinReference
xref: uniprot Q8N448 162
organism: Homo sapiens

Neuralized-like protein 4
type: ProteinReference
xref: uniprot Q5NCX5 218
organism: Mus musculus

Nicastrin
type: ProteinReference
xref: uniprot P57716 138
xref: PTHR21092:SF0
organism: Mus musculus

Serrate s16 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Serrate
stoichiometric coefficient: 1.0

Presenilin
type: ProteinReference
xref: uniprot F6YF14 145
xref: PTHR10202:SF18
organism: Xenopus tropicalis

GO GO:0005634 2
type: UnificationXref
id: GO:0005634
db: GO

Mastermind
type: Protein
entity reference: Mastermind
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Recombining binding protein suppressor of hairless
type: ProteinReference
xref: PTHR10665:SF3
xref: uniprot P31266 73
organism: Mus musculus

Recombining binding protein suppressor of hairless-like protein
type: ProteinReference
xref: PTHR10665:SF2
xref: uniprot O08674 69
organism: Mus musculus

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 142

uniprot P49769 151
type: UnificationXref
id: P49769
db: uniprot

Notch
type: Protein
entity reference: Notch
feature: Notch s41 a1 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q8JHF2 132
type: UnificationXref
id: Q8JHF2
db: uniprot

Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
type: ProteinReference
xref: PTHR10811:SF7
xref: uniprot Q924T4 134
organism: Rattus norvegicus

CIR (Transcription factor CBF1 Interacting coRepressor) homolog
type: ProteinReference
xref: PTHR13151:SF2
xref: uniprot G5EBE3 169
organism: Caenorhabditis elegans

Mastermind like transcriptional coactivator 1
type: ProteinReference
xref: uniprot H2RC16 120
xref: PTHR15692:SF19
organism: Pan troglodytes

AGAP004434-PA
type: ProteinReference
xref: uniprot Q7QA53 45
xref: PTHR45750:SF3
organism: Anopheles gambiae

Danio rerio
type: BioSource
xref: ncbitaxon 7955 59

Nicastrin
type: ProteinReference
xref: uniprot Q8GUM5 141
xref: PTHR21092:SF0
organism: Arabidopsis thaliana

Neuralized
type: ProteinReference
xref: P01117
comment: ENTITY_REFERENCE_NOTES= Long Name: Neuralized Synonym: Neu Accession: P01117
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.GENERIC.Neuralized
member entity reference: E3 ubiquitin-protein ligase NEURL1
member entity reference: Neuralized-like protein 2
member entity reference: Neuralized-like protein 4
member entity reference: Neuralized E3 ubiquitin protein ligase 1
member entity reference: Neuralized E3 ubiquitin protein ligase 2
member entity reference: G protein pathway suppressor 2 (Predicted)

GO GO:0005829 3
type: UnificationXref
id: GO:0005829
db: GO

uniprot F7GRS2 168
type: UnificationXref
id: F7GRS2
db: uniprot

PTHR24044:SF380
type: RelationshipXref
id: PTHR24044:SF380
db: PANTHER Family
relationship type: By Homology

Hairy/enhancer-of-split related with YRPW motif protein 2
type: DnaReference
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R3Z3 53
xref: PTHR10665:SF3
organism: Macaca mulatta

Notch 4
type: ProteinReference
xref: PTHR24044:SF450
xref: uniprot H2RDK4 19
organism: Pan troglodytes

Transcription factor HES-2
type: DnaReference
organism: Rattus norvegicus

uniprot H2Q8K1 147
type: UnificationXref
id: H2Q8K1
db: uniprot

Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
type: ProteinReference
xref: uniprot Q8JHF2 132
organism: Danio rerio

Delta-like protein 4
type: ProteinReference
xref: PTHR24044:SF320
xref: uniprot D3ZHH1 194
organism: Rattus norvegicus

F-box and WD repeat domain containing 7
type: ProteinReference
xref: uniprot H2QQA2 81
organism: Pan troglodytes

Uncharacterized protein
type: DnaReference
organism: Bos taurus

Fringe
type: Protein
entity reference: Fringe
comment: SPECIES_TYPE=PROTEIN

TRUNCATION_LEFT__NIct-RIGHT__Ntm-_NIcs-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 302
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 303
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 304
left: NIct
interaction type: TRUNCATION
right: NIcs
right: Ntm

uniprot O35598 113
type: UnificationXref
id: O35598
db: uniprot

NIcs
type: Protein
entity reference: NIcs
feature: NIcs s10 sa8 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa8 270
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__NIct-RIGHT__Ntm-_NIcs-_r8
controller: Complex (Pen2/Aph1/ Nicastrin/Presenilin)

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TFV4 196
xref: PTHR24044:SF308
organism: Macaca mulatta

Complex (Mastermind/Su(H)/ CoA/NIcs)
type: Complex
component stoichiometry: NIcs s10 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: Mastermind s6 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Su H s8 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: CoA s9 sa7 STOICHIOMETRY ID COMPLEX
component: Mastermind
component: CoA
component: NIcs
component: Su(H)
feature: COMPLEX BINDING FEATURE s35 a44 269
feature: COMPLEX BINDING FEATURE s35 a44 263
feature: ACTIVE 246
feature: COMPLEX BINDING FEATURE s35 a44 265
feature: COMPLEX BINDING FEATURE s35 a44 267
cellular location: nucleus

uniprot F1PZQ9 179
type: UnificationXref
id: F1PZQ9
db: uniprot

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__E_spl__C_genes-RIGHT__E_spl__C_genes-_re16
control type: INHIBITION
controller: Complex (Su(H)/CoR)

uniprot O09010 130
type: UnificationXref
id: O09010
db: uniprot

Suppressor of hairless protein
type: ProteinReference
xref: uniprot P28159 72
organism: Drosophila melanogaster

Numb
type: ProteinReference
xref: P01118
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.GENERIC.Numb
comment: ENTITY_REFERENCE_NOTES= Long Name: Numb Synonym: Synonym not specified Accession: P01118
member entity reference: Uncharacterized protein
member entity reference: Numb-related protein 1
member entity reference: NUMB, endocytic adaptor protein
member entity reference: Protein numb homolog
member entity reference: Protein numb
member entity reference: NUMB isoform 4

ncbitaxon 559292 42
type: UnificationXref
id: 559292
db: ncbitaxon

ncbitaxon 284812 50
type: UnificationXref
id: 284812
db: ncbitaxon

Notch s20 sa13 rs1
type: ModificationFeature
modification type: MODIFICATION FEATURE unknown
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.6087487659704043
comment: MODIFICATION_RESIDUE_NAME=

HETERODIMER_ASSOCIATION_LEFT__Notch-_Serrate-RIGHT__Complex__Serrate_Notch_-_r21
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 278
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 276
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 277
left: Serrate
left: Notch
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Serrate/Notch)

uniprot Q6NVP8 187
type: UnificationXref
id: Q6NVP8
db: uniprot

Enhancer of Split complex genes
type: DnaRegionReference
member entity reference: Hairy/enhancer-of-split related with YRPW motif-like (Predicted)
member entity reference: Hairy-related 6
member entity reference: Transcription factor HES-5
member entity reference: Uncharacterized protein
member entity reference: Transcription factor HES-1
member entity reference: Transcription factor HES-2
member entity reference: HEY1 isoform 1
member entity reference: Enhancer of split m5 protein
member entity reference: Enhancer of split mdelta protein
member entity reference: Enhancer of split m8 protein
member entity reference: Hairy/enhancer-of-split related with YRPW motif protein
member entity reference: Hairy/enhancer-of-split related with YRPW motif protein 1
member entity reference: Hairy/enhancer-of-split related with YRPW motif protein 2
member entity reference: HES2 isoform 2
member entity reference: Hes related family bHLH transcription factor with YRPW motif 2
member entity reference: Protein hairy
member entity reference: Transcription factor HES-4
member entity reference: Hairy/enhancer-of-split related with YRPW motif 2
member entity reference: Hairy/enhancer-of-split related with YRPW motif-like protein
member entity reference: BHLH-WRPW transcription factor
member entity reference: HES4 isoform 2
member entity reference: HEYL isoform 1
member entity reference: HES5 isoform 1
member entity reference: Hairy/enhancer-of-split related with YRPW motif protein 1 isoform a
member entity reference: Hairy and enhancer of split-related protein HELT
member entity reference: HES1 isoform 1
member entity reference: Hes family bHLH transcription factor 5
member entity reference: Enhancer of split mbeta protein
member entity reference: Enhancer of split m3 protein
member entity reference: Enhancer of split mgamma protein
member entity reference: Enhancer of split m7 protein
xref: G01541
comment: ENTITY_REFERENCE_NOTES= Long Name: Enhancer of Split complex genes Synonym: Synonym not specified Accession: G01541
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.GENE.GENE.E(spl)-C genes
display name: E(spl)-C genes

PARTICIPANT STOICHIOMETRY r18 279
type: Stoichiometry
physical entity: fucose
stoichiometric coefficient: 1.0

uniprot Q9WTS2 191
type: UnificationXref
id: Q9WTS2
db: uniprot

Fringe glycosyltransferase
type: ProteinReference
xref: PTHR10811:SF103
xref: uniprot Q24342 131
organism: Drosophila melanogaster

eco ECO:0000304 24
type: UnificationXref
id: ECO:0000304
db: eco

Presenilin homolog
type: ProteinReference
xref: PTHR10202:SF13
xref: uniprot O02194 149
organism: Drosophila melanogaster

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 32

PARTICIPANT STOICHIOMETRY r18 280
type: Stoichiometry
physical entity: Notch
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r18 281
type: Stoichiometry
physical entity: Notch
stoichiometric coefficient: 1.0

PTHR10985:SF104
type: RelationshipXref
id: PTHR10985:SF104
db: PANTHER Family
relationship type: By Homology

uniprot Q7QA53 45
type: UnificationXref
id: Q7QA53
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR15692:SF19
xref: uniprot A0A1D5RHB3 119
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PTE7 107
organism: Monodelphis domestica

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

INHIBITION
type: RelationshipTypeVocabulary

Notch s41 a1 rs1
type: ModificationFeature
modification type: MODIFICATION FEATURE unknown
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.6087487659704043
comment: MODIFICATION_RESIDUE_NAME=

uniprot V6CLJ5 78
type: UnificationXref
id: V6CLJ5
db: uniprot

Corepressor interacting with RBPJ 1
type: ProteinReference
xref: uniprot Q5U2T8 171
xref: PTHR13151:SF2
organism: Rattus norvegicus

HEYL isoform 1
type: DnaReference
xref: PTHR10985:SF79
organism: Pan troglodytes

uniprot E1B8G1 224
type: UnificationXref
id: E1B8G1
db: uniprot

Complex (Serrate/Notch)
type: Complex
component stoichiometry: Serrate s13 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: Notch s14 sa10 STOICHIOMETRY ID COMPLEX
component: Notch
component: Serrate
feature: COMPLEX BINDING FEATURE s53 a61 242
feature: ACTIVE 246
feature: COMPLEX BINDING FEATURE s53 a61 244
cellular location: cytosol

ncbitaxon 7227 52
type: UnificationXref
id: 7227
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r29 299
type: Stoichiometry
physical entity: Complex (Notch/Delta)
stoichiometric coefficient: 1.0

Next
type: Protein
entity reference: Next
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa12 254
comment: SPECIES_TYPE=PROTEIN

Recombination signal-binding protein for immunoglobulin kappa J region-like
type: ProteinReference
xref: PTHR10665:SF2
xref: uniprot D4AEG0 60
organism: Rattus norvegicus

Protein jagged-1
type: ProteinReference
xref: uniprot Q9QXX0 101
xref: PTHR24044:SF448
organism: Mus musculus

TRUNCATION
type: InteractionVocabulary

uniprot A0A1D5RHE4 165
type: UnificationXref
id: A0A1D5RHE4
db: uniprot

GH11602p
type: ProteinReference
xref: uniprot Q9VTZ1 51
xref: PTHR45750:SF3
organism: Drosophila melanogaster

Corepressor interacting with RBPJ 1
type: ProteinReference
xref: PTHR13151:SF2
xref: uniprot Q86X95 173
organism: Homo sapiens

AGAP004952-PA
type: ProteinReference
xref: PTHR13151:SF2
xref: uniprot Q7Q7Y6 172
organism: Anopheles gambiae

uniprot F1PQQ7 167
type: UnificationXref
id: F1PQQ7
db: uniprot

Neuralized E3 ubiquitin protein ligase 2
type: ProteinReference
xref: uniprot B0BMZ0 215
organism: Rattus norvegicus

Notch s14 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Notch
stoichiometric coefficient: 1.0

IDA
type: EvidenceCodeVocabulary

TRUNCATION_LEFT__Complex__Notch_Delta_-RIGHT__Complex__Delta_Next_-_NIct-_r29
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 299
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 301
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 300
left: Complex (Notch/Delta)
interaction type: TRUNCATION
right: NIct
right: Complex (Delta/Next)

Delta-like protein
type: ProteinReference
xref: uniprot H2QJZ0 95
xref: PTHR24044:SF448
organism: Pan troglodytes

PTHR24044:SF320
type: RelationshipXref
id: PTHR24044:SF320
db: PANTHER Family
relationship type: By Homology

uniprot E9PU23 89
type: UnificationXref
id: E9PU23
db: uniprot

Neurogenic locus notch homolog protein 3
type: ProteinReference
xref: PTHR45836:SF17
xref: uniprot Q9R172 39
organism: Rattus norvegicus

Delta-like protein 1
type: ProteinReference
xref: PTHR24044:SF380
xref: uniprot Q61483 208
organism: Mus musculus

Nicastrin
type: ProteinReference
xref: uniprot Q9VC27 144
xref: PTHR21092:SF0
organism: Drosophila melanogaster

uniprot Q61982 34
type: UnificationXref
id: Q61982
db: uniprot

uniprot B6RHI6 158
type: UnificationXref
id: B6RHI6
db: uniprot

uniprot Q09163 206
type: UnificationXref
id: Q09163
db: uniprot

uniprot P28159 72
type: UnificationXref
id: P28159
db: uniprot

uniprot Q91XL2 164
type: UnificationXref
id: Q91XL2
db: uniprot

Protein jagged-1
type: ProteinReference
xref: uniprot Q63722 98
xref: PTHR24044:SF448
organism: Rattus norvegicus

Hairy/enhancer-of-split related with YRPW motif protein 1
type: DnaReference
organism: Homo sapiens

uniprot Q9R172 39
type: UnificationXref
id: Q9R172
db: uniprot

uniprot Q8UWJ4 209
type: UnificationXref
id: Q8UWJ4
db: uniprot

Hairy/enhancer-of-split related with YRPW motif-like protein
type: DnaReference
xref: PTHR10985:SF79
organism: Homo sapiens

uniprot M0R7Q3 68
type: UnificationXref
id: M0R7Q3
db: uniprot

Hairy/enhancer-of-split related with YRPW motif protein 2
type: DnaReference
organism: Homo sapiens

Delta-like protein
type: ProteinReference
xref: PTHR24044:SF320
xref: uniprot Q0V7L8 207
organism: Bos taurus

Numb-related protein 1
type: ProteinReference
xref: uniprot Q9XTY6 233
organism: Caenorhabditis elegans

Protein jagged-1b
type: ProteinReference
xref: uniprot Q90Y54 99
organism: Danio rerio

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

NIct
type: ProteinReference
xref: P01119
standard name: Notch intracellular tethered fragment
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES= Long Name: Notch intracellular tethered fragment Synonym: Synonym not specified Accession: P01119
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.TRUNCATED.NI_sub_c_sub_t
member entity reference: Neurogenic locus notch homolog protein 2
member entity reference: Neurogenic locus notch homolog protein 4
member entity reference: Notch 4
member entity reference: NOTCH3 isoform 1
member entity reference: Neurogenic locus notch homolog protein 3
member entity reference: Uncharacterized protein
member entity reference: Neurogenic locus notch homolog protein 1
member entity reference: Protein glp-1
member entity reference: Notch 3
member entity reference: Notch 1
member entity reference: NOTCH1 isoform 1
member entity reference: Protein lin-12

Protein jagged-1a
type: ProteinReference
xref: uniprot Q90Y57 100
organism: Danio rerio

uniprot Q92542 143
type: UnificationXref
id: Q92542
db: uniprot

uniprot F6PTE7 107
type: UnificationXref
id: F6PTE7
db: uniprot

uniprot H2QY65 18
type: UnificationXref
id: H2QY65
db: uniprot

Protein delta homolog 1
type: ProteinReference
xref: uniprot Q09163 206
organism: Mus musculus

uniprot Q8GUM5 141
type: UnificationXref
id: Q8GUM5
db: uniprot

Presenilin hop-1
type: ProteinReference
xref: PTHR10202:SF14
xref: uniprot O02100 148
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CD96 227
xref: PTHR11232:SF33
organism: Monodelphis domestica

eco ECO:0000353 102
type: UnificationXref
id: ECO:0000353
db: eco

uniprot Q63722 98
type: UnificationXref
id: Q63722
db: uniprot

Recombination signal binding protein for immunoglobulin kappa J region
type: ProteinReference
xref: uniprot F6ULE6 62
xref: PTHR10665:SF3
organism: Ornithorhynchus anatinus

Protein jagged-2
type: ProteinReference
xref: uniprot Q9Y219 104
organism: Homo sapiens

Protein numb
type: ProteinReference
xref: PTHR11232:SF45
xref: uniprot P16554 229
organism: Drosophila melanogaster

Presenilin
type: Protein
entity reference: Presenilin
feature: COMPLEX PARTICIPANT BINDING FEATURE s36 sa18 241
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Serrate
type: Protein
entity reference: Serrate
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa11 252
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Numb-RIGHT__a25_degraded-_r26
controller: LNXp80

ncbitaxon 9913 9
type: UnificationXref
id: 9913
db: ncbitaxon

F-box/WD repeat-containing protein 7
type: ProteinReference
xref: uniprot Q969H0 83
organism: Homo sapiens

uniprot P78536 114
type: UnificationXref
id: P78536
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 42

Recombining binding protein suppressor of hairless
type: ProteinReference
xref: uniprot Q06330 75
xref: PTHR10665:SF3
organism: Homo sapiens

Yarrowia lipolytica
type: BioSource
xref: ncbitaxon 284591 48

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 52

CoR
type: ProteinReference
xref: P01112
standard name: Co-repressors
comment: ENTITY_REFERENCE_NOTES= Long Name: Co-repressors Synonym: Synonym not specified Accession: P01112
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.GENERIC.CoR
member entity reference: Nuclear receptor co-repressor 2
member entity reference: AGAP004952-PA
member entity reference: CIR (Transcription factor CBF1 Interacting coRepressor) homolog
member entity reference: Corepressor interacting with RBPJ, 1
member entity reference: Uncharacterized protein
member entity reference: Corepressor interacting with RBPJ 1
member entity reference: Nuclear receptor corepressor 2

Delta-like protein
type: ProteinReference
xref: uniprot F7C1Q4 93
xref: PTHR24044:SF448
organism: Monodelphis domestica

Notch s1 a3 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.6087487659704043
comment: MODIFICATION_RESIDUE_NAME=

uniprot Q9BYC5 189
type: UnificationXref
id: Q9BYC5
db: uniprot

PTHR10811:SF103
type: RelationshipXref
id: PTHR10811:SF103
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2UCS9 56
xref: PTHR10665:SF3
organism: Gallus gallus

uniprot P49757 230
type: UnificationXref
id: P49757
db: uniprot

ncbitaxon 39947 44
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot F6ULE6 62
type: UnificationXref
id: F6ULE6
db: uniprot

Hes family bHLH transcription factor 5
type: DnaReference
xref: PTHR10985:SF104
organism: Bos taurus

Delta-like protein
type: ProteinReference
xref: uniprot I2CVK6 96
xref: PTHR24044:SF448
organism: Macaca mulatta

Transcription factor HES-4
type: DnaReference
xref: PTHR10985:SF136
organism: Xenopus tropicalis

Enhancer of split m3 protein
type: DnaReference
xref: PTHR10985:SF12
organism: Drosophila melanogaster

Rbpja protein
type: ProteinReference
xref: uniprot A4FTT3 58
xref: PTHR10665:SF3
organism: Danio rerio

Disintegrin and metalloproteinase domain-containing protein 10
type: ProteinReference
xref: uniprot O14672 112
organism: Homo sapiens

uniprot P10041 203
type: UnificationXref
id: P10041
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: TRANSPORT_LEFT__NIcs-RIGHT__NIcs-_r10
control type: INHIBITION
controller: Numb

Suppressor of hairless homolog
type: ProteinReference
xref: PTHR10665:SF0
xref: uniprot O76808 70
organism: Ciona intestinalis

uniprot Q9WU42 176
type: UnificationXref
id: Q9WU42
db: uniprot

uniprot F7CD96 227
type: UnificationXref
id: F7CD96
db: uniprot

uniprot Q9NYJ7 212
type: UnificationXref
id: Q9NYJ7
db: uniprot

uniprot F6YB95 64
type: UnificationXref
id: F6YB95
db: uniprot

Delta s11 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Delta
stoichiometric coefficient: 1.0

uniprot Q6EV69 183
type: UnificationXref
id: Q6EV69
db: uniprot

uniprot Q04721 30
type: UnificationXref
id: Q04721
db: uniprot

Hairy/enhancer-of-split related with YRPW motif-like protein
type: DnaReference
xref: PTHR10985:SF79
organism: Mus musculus

a7_degraded
type: PhysicalEntity
comment: SPECIES_TYPE=DEGRADED

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 67

uniprot P14585 25
type: UnificationXref
id: P14585
db: uniprot

Delta
type: Protein
entity reference: Delta
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa14 258
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r13 289
type: Stoichiometry
physical entity: Su(H)
stoichiometric coefficient: 1.0

Histone acetyltransferase GCN5
type: ProteinReference
xref: uniprot Q8WZM0 47
xref: PTHR45750:SF3
organism: Yarrowia lipolytica

DLK1 isoform 1
type: ProteinReference
xref: uniprot H2RDH4 199
organism: Pan troglodytes

Next
type: ProteinReference
xref: P01103
standard name: Serrate and Notch extracellular fragment
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.TRUNCATED.N_sub_ext
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Neurogenic locus notch homolog protein 2
member entity reference: Protein jagged-1
member entity reference: Delta-like protein
member entity reference: NOTCH3 isoform 1
member entity reference: Neurogenic locus notch homolog protein 3
member entity reference: Protein jagged-1a
member entity reference: Uncharacterized protein
member entity reference: Neurogenic locus notch homolog protein 1
member entity reference: Notch 1
member entity reference: Protein jagged-1b
member entity reference: Protein jagged-2
member entity reference: Notch 3
member entity reference: NOTCH1 isoform 1
member entity reference: Protein lin-12

uniprot G5EBE3 169
type: UnificationXref
id: G5EBE3
db: uniprot

Presenilin-1
type: ProteinReference
xref: uniprot P97887 153
xref: PTHR10202:SF18
organism: Rattus norvegicus

uniprot E2QUZ3 80
type: UnificationXref
id: E2QUZ3
db: uniprot

PARTICIPANT STOICHIOMETRY r13 288
type: Stoichiometry
physical entity: NIcs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 287
type: Stoichiometry
physical entity: CoA
stoichiometric coefficient: 1.0

Delta-like protein 3
type: ProteinReference
xref: uniprot O88516 201
xref: PTHR24044:SF308
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r13 290
type: Stoichiometry
physical entity: Mastermind
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 291
type: Stoichiometry
physical entity: Complex (Mastermind/Su(H)/ CoA/NIcs)
stoichiometric coefficient: 1.0

uniprot Q9VVU4 175
type: UnificationXref
id: Q9VVU4
db: uniprot

Notch
type: Protein
entity reference: Notch
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa13 256
feature: Notch s20 sa13 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR11232:SF33
xref: uniprot A0A1D5NU12 223
organism: Gallus gallus

Notch
type: Protein
entity reference: Notch
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa10 245
feature: Notch s14 sa10 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR22804:SF52
type: RelationshipXref
id: PTHR22804:SF52
db: PANTHER Family
relationship type: By Homology

TACE
type: ProteinReference
xref: P01105
standard name: TNF-alpha converting enzyme
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.GENERIC.TACE
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: TACE Synonym: A disintegrin and metalloproteinase domain 17,ADAM17,Tumor necrosis factor alpha converting enzyme Accession: P01105
member entity reference: Disintegrin and metalloproteinase domain-containing protein 17
member entity reference: Uncharacterized protein
member entity reference: Disintegrin and metalloproteinase domain-containing protein 10
member entity reference: ADAM metallopeptidase domain 10
member entity reference: ADAM metallopeptidase domain 17

NUMB isoform 4
type: ProteinReference
xref: uniprot K7DU68 228
xref: PTHR11232:SF33
organism: Pan troglodytes

uniprot Q6MG89 36
type: UnificationXref
id: Q6MG89
db: uniprot

RBPJ isoform 12
type: ProteinReference
xref: uniprot A0A2J8NVW7 55
xref: PTHR10665:SF3
organism: Pan troglodytes

Disintegrin and metalloproteinase domain-containing protein 10
type: ProteinReference
xref: uniprot Q10741 115
organism: Bos taurus

Serrate
type: Protein
entity reference: Serrate
comment: SPECIES_TYPE=PROTEIN

Protein delta homolog 1
type: ProteinReference
xref: uniprot O70534 200
organism: Rattus norvegicus

Delta-like protein
type: ProteinReference
xref: uniprot A0A2I3S045 193
xref: PTHR24044:SF320
organism: Pan troglodytes

uniprot F1PFZ9 106
type: UnificationXref
id: F1PFZ9
db: uniprot

Presenilin s36 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Presenilin
stoichiometric coefficient: 1.0

CoA
type: Protein
entity reference: CoA
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa7 268
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Su(H)
type: Protein
entity reference: Su(H)
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 248
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q03330 41
type: UnificationXref
id: Q03330
db: uniprot

uniprot Q06330 75
type: UnificationXref
id: Q06330
db: uniprot

PARTICIPANT STOICHIOMETRY r28 307
type: Stoichiometry
physical entity: Complex (Notch/Delta)
stoichiometric coefficient: 1.0

uniprot Q9QW30 38
type: UnificationXref
id: Q9QW30
db: uniprot

PARTICIPANT STOICHIOMETRY r28 306
type: Stoichiometry
physical entity: Notch
stoichiometric coefficient: 1.0

TRUNCATION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY r28 305
type: Stoichiometry
physical entity: Delta
stoichiometric coefficient: 1.0

uniprot Q6EV76 185
type: UnificationXref
id: Q6EV76
db: uniprot

uniprot Q9VZF4 84
type: UnificationXref
id: Q9VZF4
db: uniprot

Alpha-(1,6)-fucosyltransferase
type: ProteinReference
xref: uniprot F7BVV0 181
organism: Macaca mulatta

uniprot A0A0R4IAF3 85
type: UnificationXref
id: A0A0R4IAF3
db: uniprot

Recombining binding protein suppressor of hairless-like protein
type: ProteinReference
xref: uniprot Q9UBG7 77
organism: Homo sapiens

Su(H)
type: ProteinReference
xref: P01101
standard name: Suppressor of Hairless [Su(H)]
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.GENERIC.Su(H)
comment: ENTITY_REFERENCE_NOTES= Long Name: Suppressor of Hairless [Su(H)] Synonym: C-promoter binding factor 1,CBF1,IKJRB1,Immunoglobulin Kappa J region recombination signal-binding protein 1,LAG-1 Accession: P01101
member entity reference: RBPJL isoform 1
member entity reference: Lin-12 And Glp-1 phenotype
member entity reference: Suppressor of hairless protein
member entity reference: Recombination signal binding protein for immunoglobulin kappa J region
member entity reference: Recombining binding protein suppressor of hairless
member entity reference: Recombining binding protein suppressor of hairless-like protein
member entity reference: Recombination signal-binding protein for immunoglobulin kappa J region
member entity reference: Suppressor of hairless homolog
member entity reference: Uncharacterized protein
member entity reference: RBPJ isoform 12
member entity reference: Recombination signal-binding protein for immunoglobulin kappa J region-like
member entity reference: Rbpja protein

uniprot A0A3Q1MTU2 8
type: UnificationXref
id: A0A3Q1MTU2
db: uniprot

PARTICIPANT STOICHIOMETRY r29 300
type: Stoichiometry
physical entity: Complex (Delta/Next)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r29 301
type: Stoichiometry
physical entity: NIct
stoichiometric coefficient: 1.0

Complex (Serrate/Next)
type: Complex
component stoichiometry: Serrate s16 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Next s17 sa12 STOICHIOMETRY ID COMPLEX
component: Serrate
component: Next
feature: COMPLEX BINDING FEATURE s60 a69 253
feature: COMPLEX BINDING FEATURE s60 a69 251

uniprot F6WLR7 226
type: UnificationXref
id: F6WLR7
db: uniprot

Protein jagged-1
type: ProteinReference
xref: uniprot P78504 97
xref: PTHR24044:SF448
organism: Homo sapiens

uniprot D3ZHH1 194
type: UnificationXref
id: D3ZHH1
db: uniprot

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__Su_H__CoR_-RIGHT__Su_H_-_CoR-_r11
controller: NIcs

uniprot Q9VTZ1 51
type: UnificationXref
id: Q9VTZ1
db: uniprot

Nicastrin
type: ProteinReference
xref: uniprot F1PU73 136
xref: PTHR21092:SF0
organism: Canis lupus familiaris

Bos taurus
type: BioSource
xref: ncbitaxon 9913 9

uniprot F7H8I5 15
type: UnificationXref
id: F7H8I5
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 63

NIcs s37 a46 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY
feature location: NIcs s37 a46 rs1
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Complex (Notch/Delta)
type: Complex
component stoichiometry: Notch s20 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: Delta s30 sa14 STOICHIOMETRY ID COMPLEX
component: Delta
component: Notch
feature: COMPLEX BINDING FEATURE s67 a77 257
feature: ACTIVE 246
feature: COMPLEX BINDING FEATURE s67 a77 255
cellular location: cytosol

Presenilin
type: ProteinReference
xref: uniprot H2Q8K1 147
xref: PTHR10202:SF18
organism: Pan troglodytes

Notch
type: Protein
entity reference: Notch
feature: Notch s1 a3 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Serrate
type: Protein
entity reference: Serrate
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa9 243
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

F-box/WD repeat-containing protein 7
type: ProteinReference
xref: uniprot Q9VZF4 84
organism: Drosophila melanogaster

GDP-fucose protein O-fucosyltransferase 1
type: ProteinReference
xref: uniprot Q91ZW2 188
organism: Mus musculus

PTHR45836:SF17
type: RelationshipXref
id: PTHR45836:SF17
db: PANTHER Family
relationship type: By Homology

E3 ubiquitin-protein ligase NEURL1
type: ProteinReference
xref: uniprot O76050 217
organism: Homo sapiens

Delta-like protein
type: ProteinReference
xref: uniprot F1NMD6 90
xref: PTHR24044:SF421
organism: Gallus gallus

Ub
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 12

uniprot O09008 128
type: UnificationXref
id: O09008
db: uniprot

PTHR45836:SF12
type: RelationshipXref
id: PTHR45836:SF12
db: PANTHER Family
relationship type: By Homology

PTHR45836:SF15
type: RelationshipXref
id: PTHR45836:SF15
db: PANTHER Family
relationship type: By Homology

PTHR15692:SF19
type: RelationshipXref
id: PTHR15692:SF19
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9615 12
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot Q4JIM4 154
type: UnificationXref
id: Q4JIM4
db: uniprot

Presenilin-1
type: ProteinReference
xref: uniprot Q9W6T7 156
xref: PTHR10202:SF18
organism: Danio rerio

HES1 isoform 1
type: DnaReference
xref: PTHR10985:SF19
organism: Pan troglodytes

uniprot Q9XTY6 233
type: UnificationXref
id: Q9XTY6
db: uniprot

PARTICIPANT STOICHIOMETRY r25 273
type: Stoichiometry
physical entity: Complex (Serrate/Notch)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r25 274
type: Stoichiometry
physical entity: Complex (Serrate/Next)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r25 275
type: Stoichiometry
physical entity: NIct
stoichiometric coefficient: 1.0

CoR s5 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CoR
stoichiometric coefficient: 1.0

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 57

Disintegrin and metalloproteinase domain-containing protein 17
type: ProteinReference
xref: PTHR45702:SF6
xref: uniprot P78536 114
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR22804:SF52
xref: uniprot F1PS94 13
organism: Canis lupus familiaris

Nicastrin
type: Protein
entity reference: Nicastrin
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa17 239
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Delta-like protein 3
type: ProteinReference
xref: uniprot Q9NYJ7 212
xref: PTHR24044:SF308
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR24033:SF188
xref: uniprot A0A1D5QEP8 4
organism: Macaca mulatta

uniprot Q9QYE5 103
type: UnificationXref
id: Q9QYE5
db: uniprot

uniprot F7BUF3 92
type: UnificationXref
id: F7BUF3
db: uniprot

uniprot Q86X95 173
type: UnificationXref
id: Q86X95
db: uniprot

Beta-1,3-N-acetylglucosaminyltransferase manic fringe
type: ProteinReference
xref: PTHR10811:SF6
xref: uniprot O09008 128
organism: Mus musculus

Enhancer of split m5 protein
type: DnaReference
xref: PTHR10985:SF12
organism: Drosophila melanogaster

Beta-1,3-N-acetylglucosaminyltransferase radical fringe
type: ProteinReference
xref: uniprot O09009 129
xref: PTHR10811:SF1
organism: Mus musculus

Enhancer of split m7 protein
type: DnaReference
xref: PTHR10985:SF12
organism: Drosophila melanogaster

uniprot E1B867 105
type: UnificationXref
id: E1B867
db: uniprot

Transcription factor HES-1
type: DnaReference
xref: PTHR10985:SF19
organism: Bos taurus

Ntm
type: Protein
entity reference: Ntm
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

NIcs s10 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NIcs
stoichiometric coefficient: 1.0

MODIFICATION FEATURE unknown
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

uniprot Q923S6 219
type: UnificationXref
id: Q923S6
db: uniprot

uniprot D4AEG0 60
type: UnificationXref
id: D4AEG0
db: uniprot

ncbitaxon 9031 57
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot Q969H0 83
type: UnificationXref
id: Q969H0
db: uniprot

NIcs s24 a24 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY
feature location: NIcs s24 a24 rs1
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ncbitaxon 9258 63
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot Q9Y618 177
type: UnificationXref
id: Q9Y618
db: uniprot

uniprot Q9NR61 211
type: UnificationXref
id: Q9NR61
db: uniprot

PARTICIPANT STOICHIOMETRY r16 285
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r16 284
type: Stoichiometry
physical entity: NIcs
stoichiometric coefficient: 1.0

uniprot E2QV83 61
type: UnificationXref
id: E2QV83
db: uniprot

Protein jagged-2
type: ProteinReference
xref: PTHR24044:SF421
xref: uniprot Q9QYE5 103
organism: Mus musculus

P01099
type: UnificationXref
id: P01099
db: PANTHER Pathway Component

uniprot O76808 70
type: UnificationXref
id: O76808
db: uniprot

uniprot H2QPH1 160
type: UnificationXref
id: H2QPH1
db: uniprot

PARTICIPANT STOICHIOMETRY r16 286
type: Stoichiometry
physical entity: NIcs
stoichiometric coefficient: 1.0

uniprot P78504 97
type: UnificationXref
id: P78504
db: uniprot

uniprot K7DU68 228
type: UnificationXref
id: K7DU68
db: uniprot

Sel 10
type: ProteinReference
xref: P01102
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Sel 10 Synonym: Synonym not specified Accession: P01102
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.GENERIC.Sel 10
member entity reference: F-box and WD repeat domain containing 7
member entity reference: F-box/WD repeat-containing protein sel-10
member entity reference: F-box/WD repeat-containing protein 7
member entity reference: F-box/WD repeat-containing protein 7 isoform 1

By Homology
type: RelationshipTypeVocabulary

Hairy and enhancer of split-related protein HELT
type: DnaReference
organism: Homo sapiens

PTHR47368:SF3
type: RelationshipXref
id: PTHR47368:SF3
db: PANTHER Family
relationship type: By Homology

uniprot A1A5F8 214
type: UnificationXref
id: A1A5F8
db: uniprot

uniprot A0A2I3T005 123
type: UnificationXref
id: A0A2I3T005
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 44

Alpha-(1,6)-fucosyltransferase
type: ProteinReference
xref: uniprot Q6NVP8 187
organism: Xenopus tropicalis

GDP-fucose protein O-fucosyltransferase 1
type: ProteinReference
xref: uniprot Q9H488 190
organism: Homo sapiens

Ligand of Numb protein X 2
type: ProteinReference
xref: uniprot Q91XL2 164
organism: Mus musculus

eco ECO:0000305 35
type: UnificationXref
id: ECO:0000305
db: eco

Presenilin sel-12
type: ProteinReference
xref: PTHR10202:SF13
xref: uniprot P52166 152
organism: Caenorhabditis elegans

P01102
type: UnificationXref
id: P01102
db: PANTHER Pathway Component

P01103
type: UnificationXref
id: P01103
db: PANTHER Pathway Component

P01100
type: UnificationXref
id: P01100
db: PANTHER Pathway Component

CoR
type: Protein
entity reference: CoR
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa4 250
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

P01101
type: UnificationXref
id: P01101
db: PANTHER Pathway Component

uniprot Q9QZS3 232
type: UnificationXref
id: Q9QZS3
db: uniprot

RBPJL isoform 1
type: ProteinReference
xref: uniprot A0A2J8MK73 54
organism: Pan troglodytes

PTHR10665:SF0
type: RelationshipXref
id: PTHR10665:SF0
db: PANTHER Family
relationship type: By Homology

PTHR10665:SF2
type: RelationshipXref
id: PTHR10665:SF2
db: PANTHER Family
relationship type: By Homology

PTHR10665:SF3
type: RelationshipXref
id: PTHR10665:SF3
db: PANTHER Family
relationship type: By Homology

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 46

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NIcs-_Ub-RIGHT__NIcs-_r16
controller: Sel 10

HETERODIMER_ASSOCIATION_LEFT__Delta-_Notch-RIGHT__Complex__Notch_Delta_-_r28
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 306
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 307
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 305
left: Notch
left: Delta
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Notch/Delta)

Transcription factor HES-5
type: DnaReference
xref: PTHR10985:SF104
organism: Mus musculus

uniprot P97677 205
type: UnificationXref
id: P97677
db: uniprot

Presenilin-1
type: ProteinReference
xref: uniprot Q6RH31 155
xref: PTHR10202:SF18
organism: Canis lupus familiaris

P01111
type: UnificationXref
id: P01111
db: PANTHER Pathway Component

P01112
type: UnificationXref
id: P01112
db: PANTHER Pathway Component

P01114
type: UnificationXref
id: P01114
db: PANTHER Pathway Component

uniprot A0A2I3TWA0 135
type: UnificationXref
id: A0A2I3TWA0
db: uniprot

P01110
type: UnificationXref
id: P01110
db: PANTHER Pathway Component

P01108
type: UnificationXref
id: P01108
db: PANTHER Pathway Component

uniprot Q7Q7Y6 172
type: UnificationXref
id: Q7Q7Y6
db: uniprot

P01105
type: UnificationXref
id: P01105
db: PANTHER Pathway Component

P01104
type: UnificationXref
id: P01104
db: PANTHER Pathway Component

uniprot B0BMZ0 215
type: UnificationXref
id: B0BMZ0
db: uniprot

P01107
type: UnificationXref
id: P01107
db: PANTHER Pathway Component

P01106
type: UnificationXref
id: P01106
db: PANTHER Pathway Component

Transcription factor HES-1
type: DnaReference
xref: PTHR10985:SF19
organism: Homo sapiens

Neurotic
type: Protein
entity reference: Neurotic
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3S045 193
type: UnificationXref
id: A0A2I3S045
db: uniprot

Presenilin
type: ProteinReference
xref: PTHR10202:SF18
xref: uniprot F7AGU8 146
organism: Macaca mulatta

uniprot Q9JI71 210
type: UnificationXref
id: Q9JI71
db: uniprot

uniprot Q9W6T7 156
type: UnificationXref
id: Q9W6T7
db: uniprot

Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
type: ProteinReference
xref: PTHR10811:SF7
xref: uniprot O09010 130
organism: Mus musculus

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

uniprot Q91ZW2 188
type: UnificationXref
id: Q91ZW2
db: uniprot

uniprot I2CVK6 96
type: UnificationXref
id: I2CVK6
db: uniprot

uniprot H2QQA2 81
type: UnificationXref
id: H2QQA2
db: uniprot

uniprot Q9XT97 157
type: UnificationXref
id: Q9XT97
db: uniprot

Pen2 s31 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pen2
stoichiometric coefficient: 1.0

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 102

uniprot Q23316 139
type: UnificationXref
id: Q23316
db: uniprot

PTHR12429:SF13
type: RelationshipXref
id: PTHR12429:SF13
db: PANTHER Family
relationship type: By Homology

uniprot P52166 152
type: UnificationXref
id: P52166
db: uniprot

uniprot Q90Y54 99
type: UnificationXref
id: Q90Y54
db: uniprot

eco ECO:0000316 26
type: UnificationXref
id: ECO:0000316
db: eco

PTHR13992:SF21
type: RelationshipXref
id: PTHR13992:SF21
db: PANTHER Family
relationship type: By Homology

Serrate
type: ProteinReference
xref: P01104
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Serrate Synonym: APX-1,F16B12.2,Jagged1,Jagged2 Accession: P01104
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.GENERIC.Serrate
member entity reference: Delta-like protein
member entity reference: Protein jagged-1
member entity reference: Protein jagged-1b
member entity reference: Protein jagged-2
member entity reference: Protein jagged-1a

Transcription factor HES-5
type: DnaReference
xref: PTHR10985:SF104
organism: Rattus norvegicus

HES5 isoform 1
type: DnaReference
xref: PTHR10985:SF104
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GDI5 198
organism: Macaca mulatta

uniprot Q6EV77 186
type: UnificationXref
id: Q6EV77
db: uniprot

uniprot Q9D0S4 222
type: UnificationXref
id: Q9D0S4
db: uniprot

uniprot Q9DA19 174
type: UnificationXref
id: Q9DA19
db: uniprot

Delta-like protein 4
type: ProteinReference
xref: uniprot Q9NR61 211
xref: PTHR24044:SF320
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR24044:SF415
xref: uniprot F7GL52 14
organism: Macaca mulatta

uniprot Q5F3N4 116
type: UnificationXref
id: Q5F3N4
db: uniprot

uniprot A0A2J8MK73 54
type: UnificationXref
id: A0A2J8MK73
db: uniprot

uniprot A0A1D5NU12 223
type: UnificationXref
id: A0A1D5NU12
db: uniprot

uniprot P49768 150
type: UnificationXref
id: P49768
db: uniprot

Recombination signal binding protein for immunoglobulin kappa J region
type: ProteinReference
xref: uniprot E2QV83 61
xref: PTHR10665:SF3
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r17 282
type: Stoichiometry
physical entity: NIcs
stoichiometric coefficient: 1.0

TRUNCATION_LEFT__Complex__Serrate_Notch_-RIGHT__Complex__Serrate_Next_-_NIct-_r25
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 274
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 273
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 275
left: Complex (Serrate/Notch)
interaction type: TRUNCATION
right: NIct
right: Complex (Serrate/Next)

PARTICIPANT STOICHIOMETRY r17 283
type: Stoichiometry
physical entity: a46_degraded
stoichiometric coefficient: 1.0

Neurogenic locus notch homolog protein 4
type: ProteinReference
xref: PTHR24044:SF450
xref: uniprot Q99466 37
organism: Homo sapiens

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 50

uniprot Q8NES3 133
type: UnificationXref
id: Q8NES3
db: uniprot

uniprot A4FTT3 58
type: UnificationXref
id: A4FTT3
db: uniprot

GDP-fucose protein O-fucosyltransferase 1
type: ProteinReference
xref: uniprot Q6EV70 184
organism: Rattus norvegicus

Alpha-(1,6)-fucosyltransferase
type: ProteinReference
xref: uniprot Q6EV77 186
organism: Pan troglodytes

E3 ubiquitin-protein ligase NEURL1
type: ProteinReference
xref: uniprot Q923S6 219
organism: Mus musculus

Alpha-(1,6)-fucosyltransferase
type: ProteinReference
xref: uniprot Q6EV76 185
organism: Rattus norvegicus

PTHR10202:SF18
type: RelationshipXref
id: PTHR10202:SF18
db: PANTHER Family
relationship type: By Homology

PTHR10202:SF13
type: RelationshipXref
id: PTHR10202:SF13
db: PANTHER Family
relationship type: By Homology

Protein numb homolog
type: ProteinReference
xref: PTHR11232:SF33
xref: uniprot Q2LC84 231
organism: Rattus norvegicus

PTHR10202:SF14
type: RelationshipXref
id: PTHR10202:SF14
db: PANTHER Family
relationship type: By Homology

PTHR21092:SF0
type: RelationshipXref
id: PTHR21092:SF0
db: PANTHER Family
relationship type: By Homology

uniprot Q9BR09 221
type: UnificationXref
id: Q9BR09
db: uniprot

Complex (Delta/Next)
type: Complex
component stoichiometry: Next s12 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Delta s11 sa1 STOICHIOMETRY ID COMPLEX
component: Next
component: Delta
feature: COMPLEX BINDING FEATURE s18 a18 261
feature: COMPLEX BINDING FEATURE s18 a18 259

F-box and WD repeat domain containing 7
type: ProteinReference
xref: uniprot E2QUZ3 80
organism: Canis lupus familiaris

DISSOCIATION
type: InteractionVocabulary

F-box/WD repeat-containing protein 7 isoform 1
type: ProteinReference
xref: uniprot A0A1D5Q962 79
organism: Macaca mulatta

CoA s9 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CoA
stoichiometric coefficient: 1.0

uniprot O88516 201
type: UnificationXref
id: O88516
db: uniprot

GDP-fucose protein O-fucosyltransferase 1
type: ProteinReference
xref: uniprot Q6EV69 183
organism: Pan troglodytes

CoR
type: Protein
entity reference: CoR
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Recombination signal-binding protein for immunoglobulin kappa J region
type: ProteinReference
xref: uniprot F7BXC9 66
xref: PTHR10665:SF3
organism: Xenopus tropicalis

NIcs s63 a16 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY
feature location: NIcs s63 a16 rs1
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 29

Uncharacterized protein
type: DnaReference
organism: Monodelphis domestica

Delta s30 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Delta
stoichiometric coefficient: 1.0

P01120
type: UnificationXref
id: P01120
db: PANTHER Pathway Component

uniprot A0A1D5QEP8 4
type: UnificationXref
id: A0A1D5QEP8
db: uniprot

Neuralized-like protein 2
type: ProteinReference
xref: uniprot Q9BR09 221
organism: Homo sapiens

Delta-like protein
type: ProteinReference
xref: PTHR24044:SF320
xref: uniprot F7G756 197
organism: Macaca mulatta

uniprot F6VUQ4 91
type: UnificationXref
id: F6VUQ4
db: uniprot

uniprot Q8N448 162
type: UnificationXref
id: Q8N448
db: uniprot

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

BHLH-WRPW transcription factor
type: DnaReference
xref: PTHR10985:SF136
organism: Danio rerio

PANTHER Pathway P00045 1
type: UnificationXref
id: P00045
db: PANTHER Pathway

NOTCH3 isoform 1
type: ProteinReference
xref: PTHR24033:SF176
xref: uniprot H2QFL8 16
organism: Pan troglodytes

P01117
type: UnificationXref
id: P01117
db: PANTHER Pathway Component

P01118
type: UnificationXref
id: P01118
db: PANTHER Pathway Component

P01115
type: UnificationXref
id: P01115
db: PANTHER Pathway Component

a25_degraded
type: PhysicalEntity
cellular location: cytosol
comment: SPECIES_TYPE=DEGRADED

P01116
type: UnificationXref
id: P01116
db: PANTHER Pathway Component

uniprot P57716 138
type: UnificationXref
id: P57716
db: uniprot

P01119
type: UnificationXref
id: P01119
db: PANTHER Pathway Component

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
type: ProteinReference
xref: uniprot F1P9A0 124
organism: Canis lupus familiaris

uniprot P13508 22
type: UnificationXref
id: P13508
db: uniprot

uniprot O70534 200
type: UnificationXref
id: O70534
db: uniprot

uniprot Q6RH31 155
type: UnificationXref
id: Q6RH31
db: uniprot

Nuclear receptor corepressor 2
type: ProteinReference
xref: uniprot Q9WU42 176
xref: PTHR13992:SF21
organism: Mus musculus

Alpha-(1,6)-fucosyltransferase
type: ProteinReference
xref: uniprot Q9WTS2 191
organism: Mus musculus

STATE_TRANSITION_LEFT__Delta-RIGHT__a7_degraded-_r9
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 298
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 297
left: Delta
interaction type: STATE_TRANSITION
right: a7_degraded

Mastermind
type: ProteinReference
xref: P01106
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.GENERIC.Mastermind
comment: ENTITY_REFERENCE_NOTES= Long Name: Mastermind Synonym: MECT-1,Mastermind-like 1 (MAML1),Mastermind-like2 (MAML2),Mastermind-like3(MAML3),mucoepidermoid carcinoma-translocated 1 Accession: P01106
member entity reference: Mastermind-like protein 1
member entity reference: Uncharacterized protein
member entity reference: Mastermind like transcriptional coactivator 1

Alpha-(1,6)-fucosyltransferase
type: ProteinReference
xref: uniprot F6XAH5 180
organism: Monodelphis domestica

uniprot F1PS94 13
type: UnificationXref
id: F1PS94
db: uniprot

Enhancer of split m8 protein
type: DnaReference
xref: PTHR10985:SF12
organism: Drosophila melanogaster

Delta-like protein
type: ProteinReference
xref: uniprot A0A0R4IAF3 85
xref: PTHR24049:SF18
organism: Danio rerio

Neurogenic locus notch homolog protein 1
type: ProteinReference
xref: uniprot Q07008 31
xref: PTHR22804:SF52
organism: Rattus norvegicus

uniprot O76050 217
type: UnificationXref
id: O76050
db: uniprot

TRANSCRIPTION
type: RelationshipTypeVocabulary

Alpha-(1,6)-fucosyltransferase
type: ProteinReference
xref: uniprot Q9BYC5 189
organism: Homo sapiens

Delta
type: Protein
entity reference: Delta
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa1 260
comment: SPECIES_TYPE=PROTEIN

DISSOCIATION_LEFT__Complex__Su_H__CoR_-RIGHT__Su_H_-_CoR-_r11
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 293
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 294
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 292
left: Complex (Su(H)/CoR)
interaction type: DISSOCIATION
right: Su(H)
right: CoR

uniprot A0A140T8F8 122
type: UnificationXref
id: A0A140T8F8
db: uniprot

Nicastrin
type: ProteinReference
xref: P01108
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.GENERIC.Nicastrin
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Nicastrin

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__fucose-_Notch-RIGHT__Notch-_r18
controller: Neurotic

uniprot F1N4H9 178
type: UnificationXref
id: F1N4H9
db: uniprot

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

ADAM metallopeptidase domain 17
type: ProteinReference
xref: PTHR45702:SF6
xref: uniprot F1PFZ9 106
organism: Canis lupus familiaris

uniprot Q9VC27 144
type: UnificationXref
id: Q9VC27
db: uniprot

Disintegrin and metalloproteinase domain-containing protein 10
type: ProteinReference
xref: uniprot H9EQI5 111
organism: Macaca mulatta

uniprot Q6EV70 184
type: UnificationXref
id: Q6EV70
db: uniprot

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 35

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 24

NIcs
type: Protein
entity reference: NIcs
feature: NIcs s37 a46 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F7GL52 14
type: UnificationXref
id: F7GL52
db: uniprot

uniprot Q99466 37
type: UnificationXref
id: Q99466
db: uniprot

Complex (Su(H)/CoR)
type: Complex
component stoichiometry: Su H s3 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: CoR s5 sa4 STOICHIOMETRY ID COMPLEX
component: CoR
component: Su(H)
feature: COMPLEX BINDING FEATURE s32 a37 249
feature: COMPLEX BINDING FEATURE s32 a37 247
cellular location: nucleus

Hairy/enhancer-of-split related with YRPW motif protein 1
type: DnaReference
organism: Bos taurus

NUMB, endocytic adaptor protein
type: ProteinReference
xref: uniprot F6UX21 225
xref: PTHR11232:SF33
organism: Canis lupus familiaris

uniprot Q3SZ41 76
type: UnificationXref
id: Q3SZ41
db: uniprot

uniprot Q924T4 134
type: UnificationXref
id: Q924T4
db: uniprot

uniprot F7C1Q4 93
type: UnificationXref
id: F7C1Q4
db: uniprot

Delta-like protein
type: ProteinReference
xref: uniprot E9PU23 89
xref: PTHR24044:SF421
organism: Rattus norvegicus

Delta-like protein D
type: ProteinReference
xref: PTHR24044:SF380
xref: uniprot Q8UWJ4 209
organism: Danio rerio

CoA
type: ProteinReference
xref: P01100
standard name: Co-Activators
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Co-Activators Synonym: Synonym not specified Accession: P01100
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.GENERIC.CoA
member entity reference: Histone acetyltransferase gcn5
member entity reference: Histone acetyltransferase GCN5
member entity reference: GH11602p
member entity reference: AGAP004434-PA

Next
type: Protein
entity reference: Next
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa2 262
comment: SPECIES_TYPE=PROTEIN

uniprot E2QUR0 88
type: UnificationXref
id: E2QUR0
db: uniprot

TRANSCRIPTION_LEFT__E_spl__C_genes-RIGHT__E_spl__C_genes-_re16
type: TemplateReaction
product: E(spl)-C genes
xref: TRANSCRIPTION
participant: E(spl)-C genes
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Neuralized E3 ubiquitin protein ligase 1
type: ProteinReference
xref: uniprot A0A096MJM7 213
organism: Rattus norvegicus

Delta-like protein
type: ProteinReference
xref: uniprot E2QUR0 88
xref: PTHR24044:SF448
organism: Canis lupus familiaris

HES4 isoform 2
type: DnaReference
xref: PTHR10985:SF136
organism: Pan troglodytes

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__E_spl__C_genes-RIGHT__E_spl__C_genes-_re16
control type: ACTIVATION
controller: Complex (Mastermind/Su(H)/ CoA/NIcs)

Neurogenic locus notch homolog protein 3
type: ProteinReference
xref: uniprot Q61982 34
xref: PTHR45836:SF17
organism: Mus musculus

uniprot A0A1D5RHB3 119
type: UnificationXref
id: A0A1D5RHB3
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__Notch-_Serrate-RIGHT__Complex__Serrate_Notch_-_r21
control type: INHIBITION
controller: Fringe

PTHR24044:SF448
type: RelationshipXref
id: PTHR24044:SF448
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9544 5
type: UnificationXref
id: 9544
db: ncbitaxon

Delta-like protein
type: ProteinReference
xref: uniprot F7ENN2 94
xref: PTHR24044:SF448
organism: Xenopus tropicalis

uniprot Q96JN8 220
type: UnificationXref
id: Q96JN8
db: uniprot

ncbitaxon 7955 59
type: UnificationXref
id: 7955
db: ncbitaxon

Neuralized E3 ubiquitin protein ligase 1
type: ProteinReference
xref: uniprot A1A5F8 214
xref: PTHR12429:SF13
organism: Xenopus tropicalis

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

Transcription factor HES-2
type: DnaReference
organism: Homo sapiens

eco ECO:0000270 33
type: UnificationXref
id: ECO:0000270
db: eco

Protein glp-1
type: ProteinReference
xref: PTHR24033:SF194
xref: uniprot P13508 22
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YB95 64
xref: PTHR10665:SF3
organism: Monodelphis domestica

PTHR24044:SF450
type: RelationshipXref
id: PTHR24044:SF450
db: PANTHER Family
relationship type: By Homology

PTHR13151:SF2
type: RelationshipXref
id: PTHR13151:SF2
db: PANTHER Family
relationship type: By Homology

uniprot Q5NCX5 218
type: UnificationXref
id: Q5NCX5
db: uniprot

Presenilin-1
type: ProteinReference
xref: uniprot Q9XT97 157
xref: PTHR10202:SF18
organism: Bos taurus

Protein delta homolog 1
type: ProteinReference
xref: uniprot P80370 204
organism: Homo sapiens

Delta-like protein 4
type: ProteinReference
xref: PTHR24044:SF320
xref: uniprot Q9JI71 210
organism: Mus musculus

PTHR11232:SF33
type: RelationshipXref
id: PTHR11232:SF33
db: PANTHER Family
relationship type: By Homology

E3 ubiquitin-protein ligase LNX
type: ProteinReference
xref: uniprot Q8TBB1 163
organism: Homo sapiens

DLL3 isoform 4
type: ProteinReference
xref: uniprot A0A2I3RGF5 192
xref: PTHR24044:SF308
organism: Pan troglodytes

Uncharacterized protein
type: DnaReference
organism: Macaca mulatta

uniprot Q2LC84 231
type: UnificationXref
id: Q2LC84
db: uniprot

Hairy/enhancer-of-split related with YRPW motif protein 1 isoform a
type: DnaReference
xref: PTHR10985:SF78
organism: Macaca mulatta

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 3

uniprot O02100 148
type: UnificationXref
id: O02100
db: uniprot

uniprot P46531 28
type: UnificationXref
id: P46531
db: uniprot

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 26

Fringe
type: ProteinReference
xref: P01107
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Fringe Synonym: Lunatic Fringe,Manic Fringe,Radical Fringe Accession: P01107
comment: ENTITY_REFERENCE_ID_DESC=Notch signaling pathway.PROTEIN.GENERIC.Fringe
member entity reference: Beta-1,3-N-acetylglucosaminyltransferase
member entity reference: Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
member entity reference: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
member entity reference: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
member entity reference: Beta-1,3-N-acetylglucosaminyltransferase manic fringe
member entity reference: Beta-1,3-N-acetylglucosaminyltransferase radical fringe
member entity reference: Fringe glycosyltransferase

Protein hairy
type: DnaReference
xref: PTHR10985:SF137
organism: Drosophila melanogaster

Disintegrin and metalloproteinase domain-containing protein 17
type: ProteinReference
xref: uniprot Q9Z0F8 117
xref: PTHR45702:SF6
organism: Mus musculus

uniprot H2QFL8 16
type: UnificationXref
id: H2QFL8
db: uniprot

PTHR24044:SF470
type: RelationshipXref
id: PTHR24044:SF470
db: PANTHER Family
relationship type: By Homology

PTHR11232:SF45
type: RelationshipXref
id: PTHR11232:SF45
db: PANTHER Family
relationship type: By Homology

Beta-1,3-N-acetylglucosaminyltransferase
type: ProteinReference
xref: uniprot A0A140T8F8 122
xref: PTHR10811:SF1
organism: Gallus gallus

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Complex__Notch_Delta_-RIGHT__Complex__Delta_Next_-_NIct-_r29
controller: TACE

uniprot O02194 149
type: UnificationXref
id: O02194
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__CoA-_NIcs-_Su_H_-_Mastermind-RIGHT__Complex__Mastermind_Su_H___CoA_NIcs_-_r13
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 290
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 291
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 288
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 287
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 289
left: NIcs
left: Mastermind
left: CoA
left: Su(H)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Mastermind/Su(H)/ CoA/NIcs)

Hairy/enhancer-of-split related with YRPW motif protein
type: DnaReference
organism: Drosophila melanogaster

Transcription factor HES-4
type: DnaReference
xref: PTHR10985:SF136
organism: Homo sapiens

TACE
type: Protein
entity reference: TACE
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

fucose
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A1D5Q962 79
type: UnificationXref
id: A0A1D5Q962
db: uniprot

ncbitaxon 7165 46
type: UnificationXref
id: 7165
db: ncbitaxon

Transcription factor HES-1
type: DnaReference
xref: PTHR10985:SF19
organism: Mus musculus

Aph1
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa16 237
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Complex__Serrate_Notch_-RIGHT__Complex__Serrate_Next_-_NIct-_r25
controller: TACE