uniprot P60880 76
type: UnificationXref
id: P60880
db: uniprot

Neuronal synaptobrevin, isoform J
type: ProteinReference
xref: PTHR45701:SF3
xref: uniprot M9PE71 57
organism: Drosophila melanogaster

G protein subunit alpha i3
type: ProteinReference
xref: uniprot H2PZK9 219
xref: PTHR10218:SF230
organism: Pan troglodytes

uniprot Q62442 97
type: UnificationXref
id: Q62442
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q5ZJ03 295
organism: Gallus gallus

Syntaxin-3
type: ProteinReference
xref: uniprot Q64704 99
xref: PTHR19957:SF34
organism: Mus musculus

uniprot Q7Q6D2 309
type: UnificationXref
id: Q7Q6D2
db: uniprot

G protein subunit alpha i1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F1P977 177
organism: Canis lupus familiaris

ncbitaxon 10090 14
type: UnificationXref
id: 10090
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IFL6 149
organism: Bos taurus

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot Q08462 142
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63212 272
organism: Bos taurus

By Homology
type: RelationshipTypeVocabulary

ncbitaxon 10116 17
type: UnificationXref
id: 10116
db: ncbitaxon

Mus musculus
type: BioSource
xref: ncbitaxon 10090 14

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot F6XYX9 46
organism: Monodelphis domestica

uniprot P63096 270
type: UnificationXref
id: P63096
db: uniprot

uniprot Q61017 298
type: UnificationXref
id: Q61017
db: uniprot

Delta-type opioid receptor
type: ProteinReference
xref: uniprot P33533 16
xref: PTHR24229:SF2
organism: Rattus norvegicus

uniprot O09044 61
type: UnificationXref
id: O09044
db: uniprot

PTHR19305:SF14
type: RelationshipXref
id: PTHR19305:SF14
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 265
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 264
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 262
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 263
organism: Homo sapiens

PTHR10218:SF310
type: RelationshipXref
id: PTHR10218:SF310
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot P62881 267
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 266
organism: Mus musculus

uniprot P50146 252
type: UnificationXref
id: P50146
db: uniprot

PARTICIPANT STOICHIOMETRY re11 351
type: Stoichiometry
physical entity: K+ channel
stoichiometric coefficient: 1.0

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot F6UFJ7 42
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re11 352
type: Stoichiometry
physical entity: K+ channel
stoichiometric coefficient: 1.0

hyperpolarization
type: Pathway

Proenkephalin a
type: ProteinReference
xref: PTHR11438:SF3
xref: uniprot A8E7S2 117
organism: Danio rerio

uniprot Q803H5 315
type: UnificationXref
id: Q803H5
db: uniprot

uniprot E2RJB3 170
type: UnificationXref
id: E2RJB3
db: uniprot

uniprot P52287 257
type: UnificationXref
id: P52287
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 181

uniprot Q6TH03 306
type: UnificationXref
id: Q6TH03
db: uniprot

G-protein
type: Protein
entity reference: G-protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa11 332
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9DAS9 321
type: UnificationXref
id: Q9DAS9
db: uniprot

Gnai3 protein
type: ProteinReference
xref: uniprot A9JTC8 155
xref: PTHR10218:SF230
organism: Danio rerio

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot F6WNJ9 192
organism: Xenopus tropicalis

uniprot F7G7I9 213
type: UnificationXref
id: F7G7I9
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 261
organism: Bos taurus

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot F1LQT1 133
organism: Rattus norvegicus

uniprot H2QW70 121
type: UnificationXref
id: H2QW70
db: uniprot

uniprot F6XHP0 193
type: UnificationXref
id: F6XHP0
db: uniprot

uniprot P49177 251
type: UnificationXref
id: P49177
db: uniprot

uniprot R4GKD1 327
type: UnificationXref
id: R4GKD1
db: uniprot

ncbitaxon 6669 172
type: UnificationXref
id: 6669
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot F7CTP1 202
organism: Macaca mulatta

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60879 75
xref: PTHR19305:SF5
organism: Mus musculus

uniprot F7ES96 207
type: UnificationXref
id: F7ES96
db: uniprot

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60878 73
xref: PTHR19305:SF5
organism: Gallus gallus

uniprot F7EBE7 205
type: UnificationXref
id: F7EBE7
db: uniprot

uniprot P63218 278
type: UnificationXref
id: P63218
db: uniprot

ncbitaxon 9615 34
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot P50153 255
type: UnificationXref
id: P50153
db: uniprot

Putative synaptobrevin homologue SNC1/2 (Eurofung)
type: ProteinReference
xref: uniprot Q5ASG1 92
organism: Emericella nidulans

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60877 72
xref: PTHR19305:SF5
organism: Macaca mulatta

Guanine nucleotide binding protein, beta 3
type: ProteinReference
xref: uniprot Q5XGD8 294
organism: Xenopus tropicalis

uniprot P63026 79
type: UnificationXref
id: P63026
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 12

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60880 76
xref: PTHR19305:SF5
organism: Homo sapiens

Complex (GDP/G-protein/ Sigma, Mu, Kappa)
type: Complex
component stoichiometry: G protein s8 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s3 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: Mu or Delta receptor s61 sa3 STOICHIOMETRY ID COMPLEX
component: G-protein
component: GDP
component: Mu or Delta receptor
feature: COMPLEX BINDING FEATURE s10 a9 349
feature: COMPLEX BINDING FEATURE s10 a9 347
feature: COMPLEX BINDING FEATURE s10 a9 345
cellular location: cytosol

uniprot Q9HAV0 323
type: UnificationXref
id: Q9HAV0
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q2KJD2 90
organism: Bos taurus

uniprot F6Y5F6 119
type: UnificationXref
id: F6Y5F6
db: uniprot

uniprot Q17QQ3 88
type: UnificationXref
id: Q17QQ3
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__met_Enkephalin-RIGHT__met_Enkephalin-_re2
control type: ACTIVATION
controller: SNARE COMPLEX

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63044 81
xref: PTHR45701:SF5
organism: Mus musculus

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63045 82
xref: PTHR45701:SF5
organism: Rattus norvegicus

uniprot F6W548 191
type: UnificationXref
id: F6W548
db: uniprot

ncbitaxon 3702 109
type: UnificationXref
id: 3702
db: ncbitaxon

Synaptobrevin-1
type: ProteinReference
xref: uniprot O02495 60
xref: PTHR45701:SF3
organism: Caenorhabditis elegans

ncbitaxon 6238 32
type: UnificationXref
id: 6238
db: ncbitaxon

Guanine nucleotide-binding protein subunit beta-5a
type: ProteinReference
xref: uniprot A1L271 148
organism: Danio rerio

uniprot P29387 244
type: UnificationXref
id: P29387
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZSF0 161
organism: Branchiostoma floridae

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
type: ProteinReference
xref: uniprot Q6TNT8 307
xref: PTHR10218:SF73
organism: Danio rerio

uniprot P63044 81
type: UnificationXref
id: P63044
db: uniprot

Vesicle-associated membrane protein 8 (Endobrevin)
type: ProteinReference
xref: uniprot Q7ZUC1 103
xref: PTHR45701:SF7
organism: Danio rerio

K+ channel
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6R267 127
type: UnificationXref
id: F6R267
db: uniprot

uniprot Q5R1X1 94
type: UnificationXref
id: Q5R1X1
db: uniprot

uniprot P63216 276
type: UnificationXref
id: P63216
db: uniprot

uniprot P59768 260
type: UnificationXref
id: P59768
db: uniprot

uniprot Q6DGZ5 300
type: UnificationXref
id: Q6DGZ5
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63027 80
xref: PTHR45701:SF5
organism: Homo sapiens

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63026 79
xref: PTHR45701:SF5
organism: Bos taurus

uniprot H2Q1D9 220
type: UnificationXref
id: H2Q1D9
db: uniprot

uniprot Q6P025 302
type: UnificationXref
id: Q6P025
db: uniprot

uniprot Q6DH55 301
type: UnificationXref
id: Q6DH55
db: uniprot

uniprot P63078 269
type: UnificationXref
id: P63078
db: uniprot

K+ channel
type: Protein
feature: ACTIVE 131
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q6TNT8 307
type: UnificationXref
id: Q6TNT8
db: uniprot

Proenkephalin-A
type: ProteinReference
xref: uniprot P04094 124
xref: PTHR11438:SF3
organism: Rattus norvegicus

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63024 77
organism: Mus musculus

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63025 78
organism: Rattus norvegicus

uniprot F6PVT7 183
type: UnificationXref
id: F6PVT7
db: uniprot

uniprot M9PE71 57
type: UnificationXref
id: M9PE71
db: uniprot

uniprot Q9DC51 322
type: UnificationXref
id: Q9DC51
db: uniprot

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 182
organism: Ornithorhynchus anatinus

uniprot E2RGI5 168
type: UnificationXref
id: E2RGI5
db: uniprot

uniprot F6YZA3 196
type: UnificationXref
id: F6YZA3
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R9G5 167
organism: Canis lupus familiaris

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot O70404 64
xref: PTHR45701:SF7
organism: Mus musculus

VAMP2 isoform 3
type: ProteinReference
xref: uniprot H2RCB8 56
xref: PTHR45701:SF5
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot O14775 231
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re21 369
type: Stoichiometry
physical entity: Complex (Sigma receptor/Enkephalin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re21 367
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot F6Z5I2 48
xref: PTHR45701:SF7
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re21 368
type: Stoichiometry
physical entity: Complex (GTP/G-protein)
stoichiometric coefficient: 1.0

G-protein
type: Protein
entity reference: G-protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa5 340
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 7719 318
type: UnificationXref
id: 7719
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RIM7 184
xref: PTHR10218:SF230
organism: Monodelphis domestica

uniprot Q5TZ66 95
type: UnificationXref
id: Q5TZ66
db: uniprot

uniprot Q9UK08 325
type: UnificationXref
id: Q9UK08
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 166
organism: Canis lupus familiaris

uniprot P08752 235
type: UnificationXref
id: P08752
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R2S3 165
organism: Canis lupus familiaris

GO GO:0005794 3
type: UnificationXref
id: GO:0005794
db: GO

uniprot P63025 78
type: UnificationXref
id: P63025
db: uniprot

PARTICIPANT STOICHIOMETRY re21 370
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PENK isoform 3
type: ProteinReference
xref: uniprot H2QW70 121
xref: PTHR11438:SF3
organism: Pan troglodytes

uniprot F6V461 188
type: UnificationXref
id: F6V461
db: uniprot

MODULATION
type: RelationshipTypeVocabulary

uniprot Q5BJ11 290
type: UnificationXref
id: Q5BJ11
db: uniprot

Proenkephalin b (Fragment)
type: ProteinReference
xref: PTHR11438:SF3
xref: uniprot F1QTD1 118
organism: Danio rerio

uniprot F2Z3T8 179
type: UnificationXref
id: F2Z3T8
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 10

uniprot P08754 237
type: UnificationXref
id: P08754
db: uniprot

GDP s3 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot O44419 62
type: UnificationXref
id: O44419
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re3
controller: AC

PARTICIPANT STOICHIOMETRY re21 366
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ Sigma receptor/Enkephalin)
stoichiometric coefficient: 1.0

uniprot E1C795 164
type: UnificationXref
id: E1C795
db: uniprot

G protein subunit alpha i2
type: ProteinReference
xref: uniprot H2QMN4 223
xref: PTHR10218:SF73
organism: Pan troglodytes

MODULATION
type: Control
xref: MODULATION
controlled: Analgesic
controller: cAMP

uniprot Q9LMG8 108
type: UnificationXref
id: Q9LMG8
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot O95721 65
xref: PTHR19305:SF9
organism: Homo sapiens

peptide F
type: ProteinReference
xref: P05987
comment: ENTITY_REFERENCE_ID_DESC=Opioid proenkephalin pathway.PROTEIN.GENERIC.peptide F
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: peptide F Synonym: Long Name: peptide F Accession: P05987
member entity reference: Proenkephalin
member entity reference: Proenkephalin-A
member entity reference: Proenkephalin a
member entity reference: PENK isoform 3
member entity reference: Proenkephalin b (Fragment)

leu-Enkephalin
type: Protein
entity reference: leu-Enkephalin
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5RHE7 132
type: UnificationXref
id: A0A1D5RHE7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HEV7 9
xref: PTHR24229:SF2
organism: Macaca mulatta

DISSOCIATION
type: RelationshipTypeVocabulary

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot Q9DC51 322
organism: Mus musculus

uniprot F1A421 173
type: UnificationXref
id: F1A421
db: uniprot

uniprot P63213 273
type: UnificationXref
id: P63213
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50150 253
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot P50151 254
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LYB4 26
xref: PTHR19957:SF34
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot P50154 256
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50153 255
organism: Mus musculus

G protein subunit alpha i1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F7FSE3 210
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QDW1 22
xref: PTHR19957:SF34
organism: Macaca mulatta

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P50146 252
organism: Gallus gallus

uniprot Q28HP6 89
type: UnificationXref
id: Q28HP6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SED9 39
xref: PTHR19957:SF34
organism: Monodelphis domestica

G protein s8 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-protein
stoichiometric coefficient: 1.0

Complex (GTP/G-protein)
type: Complex
component stoichiometry: G protein s16 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s15 sa4 STOICHIOMETRY ID COMPLEX
component: G-protein
component: GTP
feature: ACTIVE 131
feature: COMPLEX BINDING FEATURE s38 a44 339
feature: COMPLEX BINDING FEATURE s38 a44 337
cellular location: cytosol

uniprot F7EPG4 50
type: UnificationXref
id: F7EPG4
db: uniprot

G protein alpha subunit Gi isoform X2
type: ProteinReference
xref: uniprot Q8WSS1 317
xref: PTHR10218:SF310
organism: Ciona intestinalis

uniprot Q6PBR4 303
type: UnificationXref
id: Q6PBR4
db: uniprot

uniprot P33533 16
type: UnificationXref
id: P33533
db: uniprot

PARTICIPANT STOICHIOMETRY re8 353
type: Stoichiometry
physical entity: leu-Enkephalin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re8 354
type: Stoichiometry
physical entity: leu-Enkephalin
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot F6YMH2 47
organism: Macaca mulatta

ncbitaxon 7955 96
type: UnificationXref
id: 7955
db: ncbitaxon

STATE_TRANSITION
type: RelationshipTypeVocabulary

met-Enkephalin
type: ProteinReference
xref: P05992
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: met-Enkephalin Synonym: Long Name: met-Enkephalin Accession: P05992
comment: ENTITY_REFERENCE_ID_DESC=Opioid proenkephalin pathway.PROTEIN.GENERIC.met-Enkephalin
member entity reference: Proenkephalin
member entity reference: Proenkephalin-A
member entity reference: Proenkephalin a
member entity reference: PENK isoform 3
member entity reference: Proenkephalin b (Fragment)

Enkephalin s23 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Enkephalin
stoichiometric coefficient: 1.0

uniprot G5EEN8 52
type: UnificationXref
id: G5EEN8
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: uniprot K7ADQ0 138
xref: PTHR45627:SF9
organism: Pan troglodytes

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q9BV40 106
xref: PTHR45701:SF7
organism: Homo sapiens

uniprot F6VPY1 190
type: UnificationXref
id: F6VPY1
db: uniprot

uniprot Q9Z2P6 116
type: UnificationXref
id: Q9Z2P6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V6P8 216
organism: Rattus norvegicus

uniprot F6SSS3 185
type: UnificationXref
id: F6SSS3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A943 49
xref: PTHR45701:SF5
organism: Monodelphis domestica

Soluble NSF attachment protein 29
type: ProteinReference
xref: uniprot P83351 83
xref: PTHR19305:SF9
organism: Caenorhabditis elegans

leu-Enkephalin
type: Protein
entity reference: leu-Enkephalin
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

G protein subunit beta 5
type: ProteinReference
xref: uniprot H2Q9G5 222
organism: Pan troglodytes

uniprot P23763 67
type: UnificationXref
id: P23763
db: uniprot

Mu or Delta receptor
type: Protein
entity reference: Mu or Delta receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s63 sa12 334
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63219 279
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 278
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63217 277
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63216 276
organism: Mus musculus

uniprot F7BB02 200
type: UnificationXref
id: F7BB02
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 275
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63214 274
organism: Bos taurus

ncbitaxon 44689 248
type: UnificationXref
id: 44689
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63213 273
organism: Mus musculus

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 32

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q15KE4 282
organism: Danio rerio

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 29

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot P29829 245
organism: Drosophila melanogaster

Mu or Delta receptor
type: Protein
entity reference: Mu or Delta receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s61 sa3 350
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

G protein subunit alpha i1
type: ProteinReference
xref: uniprot A0A2I3S4R3 145
xref: PTHR10218:SF227
organism: Pan troglodytes

uniprot F1P977 177
type: UnificationXref
id: F1P977
db: uniprot

uniprot F1QTD1 118
type: UnificationXref
id: F1QTD1
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7F580 208
organism: Macaca mulatta

uniprot A0A3Q1LYB4 26
type: UnificationXref
id: A0A3Q1LYB4
db: uniprot

uniprot F7F580 208
type: UnificationXref
id: F7F580
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot Q9CXP8 320
organism: Mus musculus

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P04897 233
xref: PTHR10218:SF73
organism: Rattus norvegicus

uniprot P62874 264
type: UnificationXref
id: P62874
db: uniprot

Mu or Delta receptor
type: ProteinReference
xref: P05985
standard name: opioid receptor, delta or mu
comment: ENTITY_REFERENCE_ID_DESC=Opioid proenkephalin pathway.PROTEIN.RECEPTOR.Mu or Delta_br_receptor
comment: ENTITY_REFERENCE_NOTES= Long Name: opioid receptor, delta or mu Synonym: Synonym not specified Accession: P05985
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: OPRD1 isoform 1
member entity reference: Delta-type opioid receptor
member entity reference: Mu-type opioid receptor
member entity reference: Uncharacterized protein
member entity reference: Opioid receptor mu 1

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RGI5 168
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P04899 234
xref: PTHR10218:SF73
organism: Homo sapiens

uniprot F7A943 49
type: UnificationXref
id: F7A943
db: uniprot

uniprot P51829 141
type: UnificationXref
id: P51829
db: uniprot

Synaptobrevin
type: ProteinReference
xref: uniprot P18489 66
xref: PTHR45701:SF10
organism: Drosophila melanogaster

uniprot P26308 243
type: UnificationXref
id: P26308
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

SNAP25 homologous protein SNAP29
type: ProteinReference
xref: uniprot Q9SD96 112
organism: Arabidopsis thaliana

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 153

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 293

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P17343 240
organism: Caenorhabditis elegans

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 15

uniprot F1LQT1 133
type: UnificationXref
id: F1LQT1
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3SZ98 287
organism: Bos taurus

Synaptosomal-associated protein 25-A
type: ProteinReference
xref: uniprot Q5TZ66 95
xref: PTHR19305:SF5
organism: Danio rerio

ncbitaxon 6945 158
type: UnificationXref
id: 6945
db: ncbitaxon

uniprot P11017 238
type: UnificationXref
id: P11017
db: uniprot

uniprot A8E7S2 117
type: UnificationXref
id: A8E7S2
db: uniprot

uniprot Q7Q6E0 312
type: UnificationXref
id: Q7Q6E0
db: uniprot

uniprot Q6PHV0 101
type: UnificationXref
id: Q6PHV0
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot A5PEW5 28
organism: Caenorhabditis elegans

uniprot P42866 21
type: UnificationXref
id: P42866
db: uniprot

uniprot Q9CXP8 320
type: UnificationXref
id: Q9CXP8
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 160

uniprot Q6PH57 305
type: UnificationXref
id: Q6PH57
db: uniprot

uniprot J9P702 227
type: UnificationXref
id: J9P702
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6SSS3 185
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q1D9 220
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6W548 191
organism: Macaca mulatta

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re4
control type: INHIBITION
controller: Complex (GTP/G-protein)

DISSOCIATION_LEFT__Complex__GDP_G_protein__Sigma_receptor_Enkephalin_-_GTP-RIGHT__Complex__GTP_G_protein_-_Complex__Sigma_receptor_Enkephalin_-_GDP-_re21
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 367
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 369
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 370
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 366
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 368
left: Complex (GDP/G-protein/ Sigma receptor/Enkephalin)
left: GTP
interaction type: DISSOCIATION
right: GDP
right: Complex (GTP/G-protein)
right: Complex (Sigma receptor/Enkephalin)

GNAI2 protein
type: ProteinReference
xref: uniprot A7MBH9 154
xref: PTHR10218:SF73
organism: Bos taurus

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 7

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P52287 257
organism: Rattus norvegicus

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot F6UBJ8 40
organism: Xenopus tropicalis

Synaptobrevin homolog 2
type: ProteinReference
xref: uniprot P33328 70
organism: Saccharomyces cerevisiae

uniprot H2PZK9 219
type: UnificationXref
id: H2PZK9
db: uniprot

uniprot F6RIM7 184
type: UnificationXref
id: F6RIM7
db: uniprot

uniprot Q9S7P9 111
type: UnificationXref
id: Q9S7P9
db: uniprot

Syntaxin-3
type: ProteinReference
xref: uniprot Q13277 86
xref: PTHR19957:SF34
organism: Homo sapiens

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 6

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7AE17 228
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 163
organism: Gallus gallus

uniprot Q5BH99 289
type: UnificationXref
id: Q5BH99
db: uniprot

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 318

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot F6VUT7 44
organism: Ornithorhynchus anatinus

Synaptosomal-associated protein 23
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot O00161 59
organism: Homo sapiens

uniprot Q7PXP3 308
type: UnificationXref
id: Q7PXP3
db: uniprot

K+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

uniprot P63217 277
type: UnificationXref
id: P63217
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: hyperpolarization
controller: K+

uniprot A0A1D5QIS2 23
type: UnificationXref
id: A0A1D5QIS2
db: uniprot

uniprot Q7ZUC1 103
type: UnificationXref
id: Q7ZUC1
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot B2RSH2 156
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 212
organism: Monodelphis domestica

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot A0A1D5RHE7 132
organism: Macaca mulatta

Vesicle associated membrane protein 1
type: ProteinReference
xref: uniprot F1PRG8 36
xref: PTHR45701:SF1
organism: Canis lupus familiaris

uniprot P08753 236
type: UnificationXref
id: P08753
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P08752 235
xref: PTHR10218:SF73
organism: Mus musculus

Proenkephalin-A
type: ProteinReference
xref: uniprot P01210 122
xref: PTHR11438:SF3
organism: Homo sapiens

uniprot Q13277 86
type: UnificationXref
id: Q13277
db: uniprot

Proenkephalin-A
type: ProteinReference
xref: uniprot P01211 123
xref: PTHR11438:SF3
organism: Bos taurus

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot P08754 237
xref: PTHR10218:SF230
organism: Homo sapiens

uniprot Q3ZCA7 288
type: UnificationXref
id: Q3ZCA7
db: uniprot

Guanine nucleotide-binding protein G(K) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot F6VL43 189
organism: Macaca mulatta

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot P08753 236
xref: PTHR10218:SF230
organism: Rattus norvegicus

Proenkephalin-B
type: ProteinReference
xref: PTHR11438:SF4
xref: uniprot P01213 128
organism: Homo sapiens

uniprot Q08849 84
type: UnificationXref
id: Q08849
db: uniprot

uniprot P62879 265
type: UnificationXref
id: P62879
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9ERB0 107
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DF43 299
organism: Xenopus tropicalis

uniprot P33328 70
type: UnificationXref
id: P33328
db: uniprot

uniprot G3V6P8 216
type: UnificationXref
id: G3V6P8
db: uniprot

STATE_TRANSITION_LEFT__K_PLUS__channel-RIGHT__K_PLUS__channel-_re11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 352
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 351
left: K+ channel
interaction type: STATE_TRANSITION
right: K+ channel

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 323
organism: Homo sapiens

uniprot Q61016 297
type: UnificationXref
id: Q61016
db: uniprot

uniprot Q9N0Y0 110
type: UnificationXref
id: Q9N0Y0
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot Q10282 281
organism: Schizosaccharomyces pombe

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa1 346
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PDYN isoform 1
type: ProteinReference
xref: PTHR11438:SF4
xref: uniprot A0A2J8MS47 126
organism: Pan troglodytes

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P38400 249
xref: PTHR10218:SF73
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RJB3 170
organism: Canis lupus familiaris

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 109

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P18851 241
organism: Saccharomyces cerevisiae

uniprot P63077 268
type: UnificationXref
id: P63077
db: uniprot

Guanine nucleotide-binding protein subunit beta-5b
type: ProteinReference
xref: uniprot Q6PBY0 304
organism: Danio rerio

Gbeta5
type: ProteinReference
xref: uniprot Q9W3J1 326
organism: Drosophila melanogaster

PTHR45701:SF6
type: RelationshipXref
id: PTHR45701:SF6
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF7
type: RelationshipXref
id: PTHR45701:SF7
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1PJE5 178
organism: Canis lupus familiaris

G protein subunit gamma 5
type: ProteinReference
xref: uniprot H2PZA6 218
organism: Pan troglodytes

PTHR45701:SF5
type: RelationshipXref
id: PTHR45701:SF5
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF3
type: RelationshipXref
id: PTHR45701:SF3
db: PANTHER Family
relationship type: By Homology

GTP s15 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot F6UBJ8 40
type: UnificationXref
id: F6UBJ8
db: uniprot

ncbitaxon 7668 63
type: UnificationXref
id: 7668
db: ncbitaxon

PTHR45701:SF1
type: RelationshipXref
id: PTHR45701:SF1
db: PANTHER Family
relationship type: By Homology

uniprot F6Y3N2 195
type: UnificationXref
id: F6Y3N2
db: uniprot

uniprot P62873 263
type: UnificationXref
id: P62873
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot Q9UK08 325
organism: Homo sapiens

GDP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Danio rerio
type: BioSource
xref: ncbitaxon 7955 96

ncbitaxon 9606 20
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot F6VUT7 44
type: UnificationXref
id: F6VUT7
db: uniprot

ncbitaxon 7165 38
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot E2R907 35
type: UnificationXref
id: E2R907
db: uniprot

ncbitaxon 214684 293
type: UnificationXref
id: 214684
db: ncbitaxon

Syntaxin-3
type: ProteinReference
xref: uniprot Q08849 84
xref: PTHR19957:SF34
organism: Rattus norvegicus

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 146
organism: Pan troglodytes

uniprot B2RSH2 156
type: UnificationXref
id: B2RSH2
db: uniprot

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q17QQ3 88
organism: Bos taurus

TRANSPORT_LEFT__leu_Enkephalin-RIGHT__leu_Enkephalin-_re8
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 353
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 354
left: leu-Enkephalin
interaction type: TRANSPORT
right: leu-Enkephalin

uniprot Q3T0Y8 91
type: UnificationXref
id: Q3T0Y8
db: uniprot

uniprot F7A472 198
type: UnificationXref
id: F7A472
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot Q9N0Y0 110
xref: PTHR45701:SF5
organism: Macaca mulatta

Mu or Delta receptor
type: Protein
entity reference: Mu or Delta receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s62 sa8 342
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7E427 204
type: UnificationXref
id: F7E427
db: uniprot

uniprot P04899 234
type: UnificationXref
id: P04899
db: uniprot

ACTIVE 131
type: EntityFeature
comment: Active state

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q3T0Y8 91
organism: Bos taurus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P36975 71
xref: PTHR19305:SF14
organism: Drosophila melanogaster

uniprot A4IGZ2 150
type: UnificationXref
id: A4IGZ2
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 196
organism: Monodelphis domestica

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q15836 87
organism: Homo sapiens

Proenkephalin
type: ProteinReference
xref: PTHR11438:SF3
xref: uniprot F6Y5F6 119
organism: Xenopus tropicalis

uniprot P50150 253
type: UnificationXref
id: P50150
db: uniprot

uniprot Q7Q6D4 311
type: UnificationXref
id: Q7Q6D4
db: uniprot

uniprot F1MYW8 175
type: UnificationXref
id: F1MYW8
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot P63097 271
xref: PTHR10218:SF227
organism: Bos taurus

uniprot F7DL70 137
type: UnificationXref
id: F7DL70
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P63096 270
organism: Homo sapiens

Enkephalin s27 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Enkephalin
stoichiometric coefficient: 1.0

Synaptosomal-associated protein 25-B
type: ProteinReference
xref: uniprot Q6PC54 100
xref: PTHR19305:SF5
organism: Danio rerio

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot O44419 62
organism: Strongylocentrotus purpuratus

uniprot P60878 73
type: UnificationXref
id: P60878
db: uniprot

uniprot H2Q9G5 222
type: UnificationXref
id: H2Q9G5
db: uniprot

uniprot P01210 122
type: UnificationXref
id: P01210
db: uniprot

exocytic vesicle
type: CellularLocationVocabulary
xref: GO GO:0070382 2

Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
type: ProteinReference
xref: uniprot Q6DH55 301
organism: Danio rerio

uniprot P63024 77
type: UnificationXref
id: P63024
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6TFY2 186
organism: Macaca mulatta

uniprot P22005 125
type: UnificationXref
id: P22005
db: uniprot

uniprot F7CXD0 203
type: UnificationXref
id: F7CXD0
db: uniprot

PARTICIPANT STOICHIOMETRY re2 359
type: Stoichiometry
physical entity: met-Enkephalin
stoichiometric coefficient: 1.0

uniprot Q2KJD2 90
type: UnificationXref
id: Q2KJD2
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q62442 97
xref: PTHR45701:SF1
organism: Mus musculus

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 17

uniprot Q15KE4 282
type: UnificationXref
id: Q15KE4
db: uniprot

K+
type: SmallMolecule
comment: SPECIES_TYPE=ION

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 172

INHIBITION
type: RelationshipTypeVocabulary

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63078 269
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 268
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re2 360
type: Stoichiometry
physical entity: met-Enkephalin
stoichiometric coefficient: 1.0

uniprot A0A2I3SR99 25
type: UnificationXref
id: A0A2I3SR99
db: uniprot

uniprot Q7SZZ5 102
type: UnificationXref
id: Q7SZZ5
db: uniprot

LD03592p
type: ProteinReference
xref: uniprot Q9W1I8 114
xref: PTHR19305:SF9
organism: Drosophila melanogaster

Mu-type opioid receptor
type: ProteinReference
xref: PTHR24229:SF7
xref: uniprot P33535 18
organism: Rattus norvegicus

AC
type: ProteinReference
xref: P05993
standard name: adenylate cyclase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Opioid proenkephalin pathway.PROTEIN.GENERIC.AC
comment: ENTITY_REFERENCE_NOTES= Long Name: adenylate cyclase Synonym: Long Name: AC,adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclase Accession: P05993
member entity reference: Adenylate cyclase type 7
member entity reference: Adenylate cyclase
member entity reference: Adenylate cyclase type 2

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 259
organism: Rattus norvegicus

uniprot F7HEV7 9
type: UnificationXref
id: F7HEV7
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 258
organism: Rattus norvegicus

Putative SNAP25 homologous protein SNAP30
type: ProteinReference
xref: uniprot Q9LMG8 108
organism: Arabidopsis thaliana

ncbitaxon 7227 58
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot Q5KI86 292
type: UnificationXref
id: Q5KI86
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 204
organism: Ornithorhynchus anatinus

Proenkephalin-B
type: ProteinReference
xref: PTHR11438:SF4
xref: uniprot Q95104 130
organism: Bos taurus

uniprot F7GI54 214
type: UnificationXref
id: F7GI54
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q0V7N0 85
xref: PTHR45701:SF1
organism: Bos taurus

Adenylate cyclase
type: ProteinReference
xref: uniprot F6V001 135
xref: PTHR45627:SF6
organism: Monodelphis domestica

MODULATION
type: Control
xref: MODULATION
controlled: fine motor control
controller: cAMP

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 305
organism: Danio rerio

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: uniprot Q7T3D3 313
xref: PTHR10218:SF227
organism: Danio rerio

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot F1MJV4 134
organism: Bos taurus

TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re12
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 376
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 375
left: K+
interaction type: TRANSPORT
right: K+

uniprot E2RHY4 169
type: UnificationXref
id: E2RHY4
db: uniprot

GTP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 227321 93
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot O60262 232
type: UnificationXref
id: O60262
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 174

G-protein
type: Protein
entity reference: G-protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa2 348
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

peptide F
type: Protein
entity reference: peptide F
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

PTHR19957:SF34
type: RelationshipXref
id: PTHR19957:SF34
db: PANTHER Family
relationship type: By Homology

uniprot P29829 245
type: UnificationXref
id: P29829
db: uniprot

uniprot Q10282 281
type: UnificationXref
id: Q10282
db: uniprot

uniprot Q5XGD8 294
type: UnificationXref
id: Q5XGD8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QIS2 23
xref: PTHR45701:SF7
organism: Macaca mulatta

uniprot Q7T3D3 313
type: UnificationXref
id: Q7T3D3
db: uniprot

PTHR11438:SF3
type: RelationshipXref
id: PTHR11438:SF3
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9913 27
type: UnificationXref
id: 9913
db: ncbitaxon

PTHR11438:SF4
type: RelationshipXref
id: PTHR11438:SF4
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot Q5ASG1 92
type: UnificationXref
id: Q5ASG1
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot H2Q995 54
organism: Pan troglodytes

uniprot E2QUL2 33
type: UnificationXref
id: E2QUL2
db: uniprot

Guanine nucleotide-binding protein (G protein), beta 5
type: ProteinReference
xref: uniprot F7EBE7 205
organism: Xenopus tropicalis

AC
type: Protein
entity reference: AC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6V461 188
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P16520 239
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P59768 260
organism: Homo sapiens

ncbitaxon 665079 153
type: UnificationXref
id: 665079
db: ncbitaxon

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 93

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6PBR4 303
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DGZ5 300
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot J9P702 227
organism: Canis lupus familiaris

uniprot Q6PC54 100
type: UnificationXref
id: Q6PC54
db: uniprot

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot A0A2I3SR99 25
xref: PTHR45701:SF7
organism: Pan troglodytes

P05989
type: UnificationXref
id: P05989
db: PANTHER Pathway Component

P05988
type: UnificationXref
id: P05988
db: PANTHER Pathway Component

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot A0A1D5QYR9 24
organism: Macaca mulatta

P05993
type: UnificationXref
id: P05993
db: PANTHER Pathway Component

P05994
type: UnificationXref
id: P05994
db: PANTHER Pathway Component

P05991
type: UnificationXref
id: P05991
db: PANTHER Pathway Component

P05992
type: UnificationXref
id: P05992
db: PANTHER Pathway Component

uniprot A0A1D5QYR9 24
type: UnificationXref
id: A0A1D5QYR9
db: uniprot

P05995
type: UnificationXref
id: P05995
db: PANTHER Pathway Component

Gi alpha subunit
type: ProteinReference
xref: uniprot C3XY80 159
xref: PTHR10218:SF310
organism: Branchiostoma floridae

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot F7FXA9 211
organism: Macaca mulatta

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2b
type: ProteinReference
xref: uniprot X1WDQ5 328
xref: PTHR10218:SF73
organism: Danio rerio

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot P29387 244
organism: Mus musculus

P05985
type: UnificationXref
id: P05985
db: PANTHER Pathway Component

P05986
type: UnificationXref
id: P05986
db: PANTHER Pathway Component

P05987
type: UnificationXref
id: P05987
db: PANTHER Pathway Component

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot F5HMS4 37
organism: Anopheles gambiae

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QZN8 225
organism: Pan troglodytes

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 290
organism: Danio rerio

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 69

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 58

Uncharacterized protein
type: ProteinReference
xref: uniprot H2Q3R5 53
xref: PTHR19957:SF34
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 296
organism: Mus musculus

uniprot A4IFL6 149
type: UnificationXref
id: A4IFL6
db: uniprot

uniprot E2R2S8 166
type: UnificationXref
id: E2R2S8
db: uniprot

uniprot H2RCB8 56
type: UnificationXref
id: H2RCB8
db: uniprot

AGAP001506-PA
type: ProteinReference
xref: uniprot Q7PXP3 308
organism: Anopheles gambiae

PTHR24229:SF2
type: RelationshipXref
id: PTHR24229:SF2
db: PANTHER Family
relationship type: By Homology

PTHR24229:SF7
type: RelationshipXref
id: PTHR24229:SF7
db: PANTHER Family
relationship type: By Homology

PTHR10218:SF227
type: RelationshipXref
id: PTHR10218:SF227
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 297
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot Q61017 298
organism: Mus musculus

uniprot F7CFG8 201
type: UnificationXref
id: F7CFG8
db: uniprot

uniprot H2Q3R5 53
type: UnificationXref
id: H2Q3R5
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__K_PLUS__channel-RIGHT__K_PLUS__channel-_re11
controller: Complex (GTP/G-protein)

uniprot E2R2S3 165
type: UnificationXref
id: E2R2S3
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot Q9Z2P6 116
xref: PTHR19305:SF9
organism: Rattus norvegicus

uniprot P63212 272
type: UnificationXref
id: P63212
db: uniprot

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q9WUF4 115
xref: PTHR45701:SF7
organism: Rattus norvegicus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q5R1X1 94
xref: PTHR19305:SF5
organism: Pan troglodytes

uniprot P04897 233
type: UnificationXref
id: P04897
db: uniprot

uniprot K7AE17 228
type: UnificationXref
id: K7AE17
db: uniprot

PTHR10218:SF230
type: RelationshipXref
id: PTHR10218:SF230
db: PANTHER Family
relationship type: By Homology

uniprot P62872 262
type: UnificationXref
id: P62872
db: uniprot

uniprot P63215 275
type: UnificationXref
id: P63215
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 41

GO GO:0070382 2
type: UnificationXref
id: GO:0070382
db: GO

uniprot P36408 247
type: UnificationXref
id: P36408
db: uniprot

DISSOCIATION_LEFT__proenkephalin-RIGHT__met_Enkephalin-_peptide_E-_leu_Enkephalin-_peptide_F-_re1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 365
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 364
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 363
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 362
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 361
left: proenkephalin
interaction type: DISSOCIATION
right: peptide F
right: met-Enkephalin
right: peptide E
right: leu-Enkephalin

TRIGGER
type: RelationshipTypeVocabulary

ncbitaxon 284812 105
type: UnificationXref
id: 284812
db: ncbitaxon

ncbitaxon 6239 29
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot Q92356 104
type: UnificationXref
id: Q92356
db: uniprot

uniprot P50154 256
type: UnificationXref
id: P50154
db: uniprot

uniprot P63219 279
type: UnificationXref
id: P63219
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot O14610 230
organism: Homo sapiens

uniprot Q9BV40 106
type: UnificationXref
id: Q9BV40
db: uniprot

uniprot A0A2I3S4R3 145
type: UnificationXref
id: A0A2I3S4R3
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P49177 251
organism: Arabidopsis thaliana

uniprot P16520 239
type: UnificationXref
id: P16520
db: uniprot

ncbitaxon 9031 74
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot H2QZN8 225
type: UnificationXref
id: H2QZN8
db: uniprot

uniprot H2R3A6 226
type: UnificationXref
id: H2R3A6
db: uniprot

uniprot A5PKD6 151
type: UnificationXref
id: A5PKD6
db: uniprot

Golgi apparatus
type: CellularLocationVocabulary
xref: GO GO:0005794 3

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 238
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re1 365
type: Stoichiometry
physical entity: peptide F
stoichiometric coefficient: 1.0

uniprot F7FSE3 210
type: UnificationXref
id: F7FSE3
db: uniprot

uniprot Q9VH76 113
type: UnificationXref
id: Q9VH76
db: uniprot

PARTICIPANT STOICHIOMETRY re12 375
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

uniprot D3ZLD6 162
type: UnificationXref
id: D3ZLD6
db: uniprot

uniprot Q64704 99
type: UnificationXref
id: Q64704
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T7 215
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re1 361
type: Stoichiometry
physical entity: proenkephalin
stoichiometric coefficient: 1.0

ncbitaxon 7739 160
type: UnificationXref
id: 7739
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re1 362
type: Stoichiometry
physical entity: met-Enkephalin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 363
type: Stoichiometry
physical entity: peptide E
stoichiometric coefficient: 1.0

uniprot P41143 19
type: UnificationXref
id: P41143
db: uniprot

ncbitaxon 8364 41
type: UnificationXref
id: 8364
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re1 364
type: Stoichiometry
physical entity: leu-Enkephalin
stoichiometric coefficient: 1.0

uniprot K7E376 229
type: UnificationXref
id: K7E376
db: uniprot

uniprot Q61011 296
type: UnificationXref
id: Q61011
db: uniprot

uniprot P54313 259
type: UnificationXref
id: P54313
db: uniprot

PANTHER Pathway P05915 1
type: UnificationXref
id: P05915
db: PANTHER Pathway

PARTICIPANT STOICHIOMETRY re12 376
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot E2QUL2 33
xref: PTHR45701:SF7
organism: Canis lupus familiaris

uniprot P60879 75
type: UnificationXref
id: P60879
db: uniprot

uniprot P62881 267
type: UnificationXref
id: P62881
db: uniprot

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot F5HH30 180
organism: Neurospora crassa

MODULATION
type: Control
xref: MODULATION
controlled: fine motor control
controller: K+

eco ECO:0000305 30
type: UnificationXref
id: ECO:0000305
db: eco

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P43425 250
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IGZ2 150
organism: Xenopus tropicalis

fine motor control
type: Pathway

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q28024 284
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re20 373
type: Stoichiometry
physical entity: met-Enkephalin
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XWE8 194
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re20 374
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ Sigma receptor/Enkephalin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re20 371
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ Sigma, Mu, Kappa)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re20 372
type: Stoichiometry
physical entity: leu-Enkephalin
stoichiometric coefficient: 1.0

uniprot P62871 261
type: UnificationXref
id: P62871
db: uniprot

uniprot A0A2J8MS47 126
type: UnificationXref
id: A0A2J8MS47
db: uniprot

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot Q92356 104
organism: Schizosaccharomyces pombe

AGAP005904-PA
type: ProteinReference
xref: uniprot Q7Q6E0 312
xref: PTHR10218:SF310
organism: Anopheles gambiae

uniprot G7MZE3 120
type: UnificationXref
id: G7MZE3
db: uniprot

uniprot E2R9G5 167
type: UnificationXref
id: E2R9G5
db: uniprot

AGAP005911-PA
type: ProteinReference
xref: uniprot Q7Q6D4 311
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UJE8 187
xref: PTHR10218:SF227
organism: Monodelphis domestica

AGAP005913-PA
type: ProteinReference
xref: uniprot Q7Q6D2 309
organism: Anopheles gambiae

AGAP005912-PA
type: ProteinReference
xref: uniprot Q7Q6D3 310
organism: Anopheles gambiae

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: hyperpolarization
controller: cAMP

Bos taurus
type: BioSource
xref: ncbitaxon 9913 27

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 45

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q3W7 221
organism: Pan troglodytes

uniprot A8X8S6 31
type: UnificationXref
id: A8X8S6
db: uniprot

uniprot F6VM87 43
type: UnificationXref
id: F6VM87
db: uniprot

uniprot P62880 266
type: UnificationXref
id: P62880
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q28H40 285
organism: Xenopus tropicalis

uniprot P43425 250
type: UnificationXref
id: P43425
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P30671 246
organism: Bos taurus

G protein alpha i subunit
type: ProteinReference
xref: uniprot P20353 242
xref: PTHR10218:SF310
organism: Drosophila melanogaster

uniprot H2Q3W7 221
type: UnificationXref
id: H2Q3W7
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 158

HETERODIMER_ASSOCIATION_LEFT__Complex__GDP_G_protein__Sigma,_Mu,_Kappa_-_leu_Enkephalin-_met_Enkephalin-RIGHT__Complex__GDP_G_protein__Sigma_receptor_Enkephalin_-_re20
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 373
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 371
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 372
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 374
left: leu-Enkephalin
left: met-Enkephalin
left: Complex (GDP/G-protein/ Sigma, Mu, Kappa)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GDP/G-protein/ Sigma receptor/Enkephalin)

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot F1A421 173
organism: Dictyostelium purpureum

uniprot P36975 71
type: UnificationXref
id: P36975
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 34

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NGS8 147
organism: Bos taurus

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 224
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7G7I9 213
organism: Ornithorhynchus anatinus

uniprot Q7ZW82 314
type: UnificationXref
id: Q7ZW82
db: uniprot

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot Q80TL1 144
xref: PTHR45627:SF6
organism: Mus musculus

VAMP3 isoform 1
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot G2HIJ9 51
organism: Pan troglodytes

PTHR45701:SF10
type: RelationshipXref
id: PTHR45701:SF10
db: PANTHER Family
relationship type: By Homology

uniprot Q3SZ98 287
type: UnificationXref
id: Q3SZ98
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot E2R907 35
xref: PTHR19305:SF5
organism: Canis lupus familiaris

G protein s16 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-protein
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7CFG8 201
organism: Monodelphis domestica

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 74

uniprot P06300 129
type: UnificationXref
id: P06300
db: uniprot

cAMP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Beta-neoendorphin-dynorphin
type: ProteinReference
xref: PTHR11438:SF4
xref: uniprot F6R267 127
organism: Macaca mulatta

uniprot P83351 83
type: UnificationXref
id: P83351
db: uniprot

uniprot A0A2I3TUD1 146
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot P51828 140
organism: Homo sapiens

uniprot O14775 231
type: UnificationXref
id: O14775
db: uniprot

uniprot F6Z5I2 48
type: UnificationXref
id: F6Z5I2
db: uniprot

uniprot P63045 82
type: UnificationXref
id: P63045
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7GI54 214
organism: Monodelphis domestica

uniprot P54311 258
type: UnificationXref
id: P54311
db: uniprot

Adenylate cyclase type 7
type: ProteinReference
xref: uniprot P51829 141
xref: PTHR45627:SF9
organism: Mus musculus

uniprot F7CDR6 5
type: UnificationXref
id: F7CDR6
db: uniprot

uniprot F1MJV4 134
type: UnificationXref
id: F1MJV4
db: uniprot

SNARE COMPLEX
type: Protein
entity reference: SNARE COMPLEX
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

SNAP25 homologous protein SNAP33
type: ProteinReference
xref: uniprot Q9S7P9 111
organism: Arabidopsis thaliana

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot Q9VH76 113
organism: Drosophila melanogaster

uniprot Q9UBI6 324
type: UnificationXref
id: Q9UBI6
db: uniprot

Mu or Delta receptor s63 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Mu or Delta receptor
stoichiometric coefficient: 1.0

Gnb3 protein
type: ProteinReference
xref: uniprot Q6P025 302
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5KI86 292
organism: Cryptococcus neoformans

Guanine nucleotide binding protein, beta subunit
type: ProteinReference
xref: uniprot E9FUX0 171
organism: Daphnia pulex

uniprot F6PGC8 182
type: UnificationXref
id: F6PGC8
db: uniprot

uniprot F6XWE8 194
type: UnificationXref
id: F6XWE8
db: uniprot

uniprot P63027 80
type: UnificationXref
id: P63027
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9UBI6 324
organism: Homo sapiens

Adenylate cyclase type 7
type: ProteinReference
xref: uniprot Q29450 143
xref: PTHR45627:SF9
organism: Bos taurus

uniprot Q08462 142
type: UnificationXref
id: Q08462
db: uniprot

uniprot F6ZIZ9 197
type: UnificationXref
id: F6ZIZ9
db: uniprot

uniprot Q95104 130
type: UnificationXref
id: Q95104
db: uniprot

uniprot E9FUX0 171
type: UnificationXref
id: E9FUX0
db: uniprot

uniprot G2HIJ9 51
type: UnificationXref
id: G2HIJ9
db: uniprot

uniprot H2QLA1 55
type: UnificationXref
id: H2QLA1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 183
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 195
organism: Monodelphis domestica

THO complex subunit, putative
type: ProteinReference
xref: uniprot B7Q3T6 157
organism: Ixodes scapularis

TRANSPORT_LEFT__met_Enkephalin-RIGHT__met_Enkephalin-_re2
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 359
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 360
left: met-Enkephalin
interaction type: TRANSPORT
right: met-Enkephalin

Delta-type opioid receptor
type: ProteinReference
xref: uniprot P32300 13
xref: PTHR24229:SF2
organism: Mus musculus

MODULATION
type: Control
xref: MODULATION
controlled: Analgesic
controller: K+

uniprot F6UFJ7 42
type: UnificationXref
id: F6UFJ7
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XHP0 193
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9DAS9 321
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re4 355
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 356
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

ncbitaxon 9598 12
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot C3XY80 159
type: UnificationXref
id: C3XY80
db: uniprot

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa10 330
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Analgesic
type: Pathway

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ASR8 199
organism: Macaca mulatta

uniprot Q5ZJ03 295
type: UnificationXref
id: Q5ZJ03
db: uniprot

uniprot P60877 72
type: UnificationXref
id: P60877
db: uniprot

uniprot P26769 139
type: UnificationXref
id: P26769
db: uniprot

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P26308 243
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 358
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 357
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

proenkephalin
type: Protein
entity reference: proenkephalin
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CXD0 203
organism: Monodelphis domestica

G-protein beta subunit
type: ProteinReference
xref: uniprot Q5BH99 289
organism: Emericella nidulans

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F6VM87 43
xref: PTHR19305:SF5
organism: Monodelphis domestica

Enkephalin
type: ProteinReference
xref: P05991
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Enkephalin Synonym: Met-enkephalin ,leu-enkephalin Accession: P05991
comment: ENTITY_REFERENCE_ID_DESC=Opioid proenkephalin pathway.PROTEIN.GENERIC.Enkephalin
member entity reference: Proenkephalin
member entity reference: Proenkephalin-B
member entity reference: Proenkephalin-A
member entity reference: PDYN isoform 1
member entity reference: PENK isoform 3
member entity reference: Beta-neoendorphin-dynorphin
member entity reference: Proenkephalin a
member entity reference: Proenkephalin b (Fragment)

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 38

uniprot H2PZA6 218
type: UnificationXref
id: H2PZA6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 175
organism: Bos taurus

uniprot F5HH30 180
type: UnificationXref
id: F5HH30
db: uniprot

uniprot Q5I080 291
type: UnificationXref
id: Q5I080
db: uniprot

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot P26769 139
organism: Rattus norvegicus

uniprot Q3KRE3 286
type: UnificationXref
id: Q3KRE3
db: uniprot

uniprot A0A3Q1NGS8 147
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

Synaptosomal-associated protein 23
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot O09044 61
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7BB02 200
organism: Macaca mulatta

uniprot A5PEW5 28
type: UnificationXref
id: A5PEW5
db: uniprot

uniprot Q0V7N0 85
type: UnificationXref
id: Q0V7N0
db: uniprot

uniprot G3V8K2 217
type: UnificationXref
id: G3V8K2
db: uniprot

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 315
organism: Danio rerio

uniprot Q6DF43 299
type: UnificationXref
id: Q6DF43
db: uniprot

uniprot E1BW98 163
type: UnificationXref
id: E1BW98
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot A8X8S6 31
organism: Caenorhabditis briggsae

uniprot C3ZSF0 161
type: UnificationXref
id: C3ZSF0
db: uniprot

uniprot Q15836 87
type: UnificationXref
id: Q15836
db: uniprot

uniprot F7ASR8 199
type: UnificationXref
id: F7ASR8
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q63666 98
xref: PTHR45701:SF1
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re3 357
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 358
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot Q7SZZ5 102
organism: Danio rerio

uniprot F1PRG8 36
type: UnificationXref
id: F1PRG8
db: uniprot

uniprot Q9SD96 112
type: UnificationXref
id: Q9SD96
db: uniprot

uniprot Q29450 143
type: UnificationXref
id: Q29450
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3KRE3 286
organism: Rattus norvegicus

uniprot X1WDQ5 328
type: UnificationXref
id: X1WDQ5
db: uniprot

uniprot Q80TL1 144
type: UnificationXref
id: Q80TL1
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot E2RHY4 169
organism: Canis lupus familiaris

GO GO:0005829 4
type: UnificationXref
id: GO:0005829
db: GO

ncbitaxon 9258 45
type: UnificationXref
id: 9258
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot O60262 232
organism: Homo sapiens

uniprot F6XYX9 46
type: UnificationXref
id: F6XYX9
db: uniprot

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot Q3ZCA7 288
organism: Bos taurus

Mu or Delta receptor s62 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Mu or Delta receptor
stoichiometric coefficient: 1.0

uniprot A7EDU2 152
type: UnificationXref
id: A7EDU2
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot D3ZLD6 162
organism: Rattus norvegicus

uniprot Q7Q6D3 310
type: UnificationXref
id: Q7Q6D3
db: uniprot

uniprot F6SED9 39
type: UnificationXref
id: F6SED9
db: uniprot

G-protein
type: ProteinReference
xref: P05994
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: G-protein Synonym: Synonym not specified Accession: P05994
comment: ENTITY_REFERENCE_ID_DESC=Opioid proenkephalin pathway.PROTEIN.GENERIC.G-protein
member entity reference: Gnb1l protein
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: Guanine nucleotide-binding protein subunit beta-5
member entity reference: G protein subunit alpha i3
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
member entity reference: Gnai3 protein
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: Guanine nucleotide-binding protein subunit beta-4
member entity reference: G protein subunit beta 5
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
member entity reference: G protein subunit alpha i1
member entity reference: Guanine nucleotide-binding protein subunit beta-5a
member entity reference: Gnb2 protein
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
member entity reference: Guanine nucleotide-binding protein subunit beta-5b
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: Guanine nucleotide-binding protein (G protein), beta 5
member entity reference: Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
member entity reference: G protein subunit gamma 5
member entity reference: Guanine nucleotide-binding protein subunit beta-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1
member entity reference: G protein subunit beta 2
member entity reference: Guanine nucleotide-binding protein subunit beta-1
member entity reference: Guanine nucleotide binding protein, beta 3

uniprot A0A1D5QDW1 22
type: UnificationXref
id: A0A1D5QDW1
db: uniprot

PTHR19305:SF5
type: RelationshipXref
id: PTHR19305:SF5
db: PANTHER Family
relationship type: By Homology

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 105

G protein s25 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-protein
stoichiometric coefficient: 1.0

PTHR19305:SF9
type: RelationshipXref
id: PTHR19305:SF9
db: PANTHER Family
relationship type: By Homology

met-Enkephalin
type: Protein
entity reference: met-Enkephalin
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa4 338
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

AC
type: Protein
entity reference: AC
feature: ACTIVE 131
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q8WSS1 317
type: UnificationXref
id: Q8WSS1
db: uniprot

uniprot F6V001 135
type: UnificationXref
id: F6V001
db: uniprot

uniprot P63097 271
type: UnificationXref
id: P63097
db: uniprot

Mu-type opioid receptor
type: ProteinReference
xref: PTHR24229:SF7
xref: uniprot P42866 21
organism: Mus musculus

uniprot P18489 66
type: UnificationXref
id: P18489
db: uniprot

uniprot F7H6T7 215
type: UnificationXref
id: F7H6T7
db: uniprot

PTHR19305:SF4
type: RelationshipXref
id: PTHR19305:SF4
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q0VFC4 280
organism: Xenopus tropicalis

uniprot Q28024 284
type: UnificationXref
id: Q28024
db: uniprot

uniprot H2Q995 54
type: UnificationXref
id: H2Q995
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6TH03 306
organism: Danio rerio

uniprot F7ERP8 206
type: UnificationXref
id: F7ERP8
db: uniprot

uniprot A7MBH9 154
type: UnificationXref
id: A7MBH9
db: uniprot

Proenkephalin-A
type: ProteinReference
xref: PTHR11438:SF3
xref: uniprot P22005 125
organism: Mus musculus

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot Q20636 283
organism: Caenorhabditis elegans

leu-Enkephalin
type: ProteinReference
xref: P05989
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: leu-Enkephalin Synonym: Long Name: leu-Enkephalin Accession: P05989
comment: ENTITY_REFERENCE_ID_DESC=Opioid proenkephalin pathway.PROTEIN.GENERIC.leu-Enkephalin
member entity reference: Proenkephalin
member entity reference: Proenkephalin-A
member entity reference: Proenkephalin a
member entity reference: PENK isoform 3
member entity reference: Proenkephalin b (Fragment)

uniprot O70404 64
type: UnificationXref
id: O70404
db: uniprot

uniprot F5HMS4 37
type: UnificationXref
id: F5HMS4
db: uniprot

GNB4 protein
type: ProteinReference
xref: uniprot A5PKD6 151
organism: Bos taurus

peptide E
type: ProteinReference
xref: P05988
comment: ENTITY_REFERENCE_ID_DESC=Opioid proenkephalin pathway.PROTEIN.GENERIC.peptide E
comment: ENTITY_REFERENCE_NOTES= Long Name: peptide E Synonym: Long Name: peptide E Accession: P05988
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Proenkephalin
member entity reference: Proenkephalin-A
member entity reference: Proenkephalin a
member entity reference: PENK isoform 3
member entity reference: Proenkephalin b (Fragment)

ncbitaxon 5786 174
type: UnificationXref
id: 5786
db: ncbitaxon

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 20

Complex (Sigma receptor/Enkephalin)
type: Complex
component stoichiometry: Mu or Delta receptor s62 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: Enkephalin s23 sa9 STOICHIOMETRY ID COMPLEX
component: Mu or Delta receptor
component: Enkephalin
feature: COMPLEX BINDING FEATURE s53 a60 343
feature: COMPLEX BINDING FEATURE s53 a60 341
cellular location: cytosol

Mu or Delta receptor s61 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Mu or Delta receptor
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot F7FD32 209
organism: Macaca mulatta

peptide E
type: Protein
entity reference: peptide E
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot P18851 241
type: UnificationXref
id: P18851
db: uniprot

uniprot P30671 246
type: UnificationXref
id: P30671
db: uniprot

uniprot P51828 140
type: UnificationXref
id: P51828
db: uniprot

STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 356
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 355
left: AC
interaction type: STATE_TRANSITION
right: AC

uniprot F7G3J2 212
type: UnificationXref
id: F7G3J2
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot Q28HP6 89
xref: PTHR19305:SF5
organism: Xenopus tropicalis

uniprot Q0VFC4 280
type: UnificationXref
id: Q0VFC4
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
type: ProteinReference
xref: uniprot Q7ZW82 314
xref: PTHR10218:SF227
organism: Danio rerio

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 63

Proenkephalin-B
type: ProteinReference
xref: PTHR11438:SF4
xref: uniprot P06300 129
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E1C795 164
organism: Gallus gallus

medium spiny neuron of striatum c1
type: CellularLocationVocabulary
comment: medium spiny neuron of striatum

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot R4GKD1 327
organism: Gallus gallus

uniprot F1NLV4 176
type: UnificationXref
id: F1NLV4
db: uniprot

uniprot K7ADQ0 138
type: UnificationXref
id: K7ADQ0
db: uniprot

uniprot Q9WUF4 115
type: UnificationXref
id: Q9WUF4
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 207
organism: Macaca mulatta

uniprot Q28H40 285
type: UnificationXref
id: Q28H40
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NLV4 176
organism: Gallus gallus

uniprot B7Q3T6 157
type: UnificationXref
id: B7Q3T6
db: uniprot

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot P31109 68
organism: Saccharomyces cerevisiae

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V8K2 217
organism: Rattus norvegicus

PTHR10218:SF73
type: RelationshipXref
id: PTHR10218:SF73
db: PANTHER Family
relationship type: By Homology

eco ECO:0000245 15
type: UnificationXref
id: ECO:0000245
db: eco

uniprot O00161 59
type: UnificationXref
id: O00161
db: uniprot

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot A7EDU2 152
organism: Sclerotinia sclerotiorum

uniprot F1PJE5 178
type: UnificationXref
id: F1PJE5
db: uniprot

uniprot P32300 13
type: UnificationXref
id: P32300
db: uniprot

uniprot P01213 128
type: UnificationXref
id: P01213
db: uniprot

ncbitaxon 367110 181
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot F6WNJ9 192
type: UnificationXref
id: F6WNJ9
db: uniprot

SNAP29 isoform 1
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot H2QLA1 55
organism: Pan troglodytes

uniprot P31109 68
type: UnificationXref
id: P31109
db: uniprot

uniprot F7CTP1 202
type: UnificationXref
id: F7CTP1
db: uniprot

ncbitaxon 13616 6
type: UnificationXref
id: 13616
db: ncbitaxon

G protein subunit alpha i3
type: ProteinReference
xref: uniprot Q5I080 291
xref: PTHR10218:SF230
organism: Xenopus tropicalis

PTHR45627:SF9
type: RelationshipXref
id: PTHR45627:SF9
db: PANTHER Family
relationship type: By Homology

Opioid receptor mu 1
type: ProteinReference
xref: PTHR24229:SF7
xref: uniprot F7CDR6 5
organism: Monodelphis domestica

PTHR45627:SF6
type: RelationshipXref
id: PTHR45627:SF6
db: PANTHER Family
relationship type: By Homology

uniprot P63214 274
type: UnificationXref
id: P63214
db: uniprot

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 248

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F2Z3T8 179
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot Q20636 283
type: UnificationXref
id: Q20636
db: uniprot

uniprot P01211 123
type: UnificationXref
id: P01211
db: uniprot

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 30

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re12
control type: ACTIVATION
controller: K+ channel

proenkephalin
type: ProteinReference
xref: P05995
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: proenkephalin Synonym: Long Name: proenkephalin,PENK Accession: P05995
comment: ENTITY_REFERENCE_ID_DESC=Opioid proenkephalin pathway.PROTEIN.GENERIC.proenkephalin
member entity reference: Proenkephalin
member entity reference: Proenkephalin-A
member entity reference: Proenkephalin a
member entity reference: PENK isoform 3
member entity reference: Proenkephalin b (Fragment)

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7E376 229
organism: Monodelphis domestica

uniprot Q9ERB0 107
type: UnificationXref
id: Q9ERB0
db: uniprot

Proenkephalin-A
type: ProteinReference
xref: PTHR11438:SF3
xref: uniprot G7MZE3 120
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 316
organism: Mus musculus

ncbitaxon 9544 10
type: UnificationXref
id: 9544
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q90Z40 319
organism: Danio rerio

uniprot Q9W3J1 326
type: UnificationXref
id: Q9W3J1
db: uniprot

uniprot P33535 18
type: UnificationXref
id: P33535
db: uniprot

uniprot F6VL43 189
type: UnificationXref
id: F6VL43
db: uniprot

uniprot F6ZAV4 136
type: UnificationXref
id: F6ZAV4
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 197
organism: Macaca mulatta

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__leu_Enkephalin-RIGHT__leu_Enkephalin-_re8
control type: ACTIVATION
controller: SNARE COMPLEX

t-SNARE protein aex-4
type: ProteinReference
xref: uniprot G5EEN8 52
organism: Caenorhabditis elegans

uniprot A1L271 148
type: UnificationXref
id: A1L271
db: uniprot

Delta-type opioid receptor
type: ProteinReference
xref: uniprot P41143 19
xref: PTHR24229:SF2
organism: Homo sapiens

uniprot O14610 230
type: UnificationXref
id: O14610
db: uniprot

met-Enkephalin
type: Protein
entity reference: met-Enkephalin
comment: SPECIES_TYPE=PROTEIN

uniprot Q6PBY0 304
type: UnificationXref
id: Q6PBY0
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot P23763 67
xref: PTHR45701:SF1
organism: Homo sapiens

G protein subunit beta 3
type: ProteinReference
xref: uniprot H2R3A6 226
organism: Pan troglodytes

ncbitaxon 559292 69
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot P38400 249
type: UnificationXref
id: P38400
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: uniprot F6ZAV4 136
xref: PTHR45627:SF6
organism: Ornithorhynchus anatinus

uniprot Q63666 98
type: UnificationXref
id: Q63666
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F7A472 198
organism: Xenopus tropicalis

STATE_TRANSITION
type: InteractionVocabulary

uniprot Q90Z40 319
type: UnificationXref
id: Q90Z40
db: uniprot

OPRD1 isoform 1
type: ProteinReference
xref: uniprot H2PYH8 11
xref: PTHR24229:SF2
organism: Pan troglodytes

TRANSPORT
type: InteractionVocabulary

uniprot P17343 240
type: UnificationXref
id: P17343
db: uniprot

SNARE COMPLEX
type: ProteinReference
xref: P05986
standard name: SNARE Complex
comment: ENTITY_REFERENCE_ID_DESC=Opioid proenkephalin pathway.PROTEIN.GENERIC.SNARE COMPLEX
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: SNARE COMPLEX Synonym: Long Name: SNARE COMPLEX Accession: P05986
member entity reference: SNAP25 homologous protein SNAP29
member entity reference: Soluble NSF attachment protein 29
member entity reference: Putative SNAP25 homologous protein SNAP30
member entity reference: SNAP25 homologous protein SNAP33
member entity reference: Synaptosomal-associated protein
member entity reference: Vesicle-associated membrane protein 1
member entity reference: Uncharacterized protein
member entity reference: Synaptosomal-associated protein 25
member entity reference: Synaptosomal-associated protein 29
member entity reference: Vesicle associated membrane protein 8
member entity reference: Synaptobrevin
member entity reference: t-SNARE protein aex-4
member entity reference: Synaptobrevin homolog 2
member entity reference: Synaptosomal-associated protein 25-B
member entity reference: Vesicle-associated membrane protein 2
member entity reference: Vesicle-associated membrane protein 3
member entity reference: Syntaxin 3
member entity reference: Synaptosomal-associated protein 23
member entity reference: SNAP29 isoform 1
member entity reference: Neuronal synaptobrevin, isoform J
member entity reference: Vesicle-associated membrane protein 8 (Endobrevin)
member entity reference: Vesicle-associated membrane protein 8
member entity reference: Synaptobrevin homolog 1
member entity reference: Synaptosomal-associated protein 25-A
member entity reference: Syntaxin 3A
member entity reference: Syntaxin-3
member entity reference: Putative synaptobrevin homologue SNC1/2 (Eurofung)
member entity reference: Vesicle associated membrane protein 1
member entity reference: VAMP2 isoform 3
member entity reference: Synaptobrevin-1

uniprot A9JTC8 155
type: UnificationXref
id: A9JTC8
db: uniprot

uniprot H2QNS5 224
type: UnificationXref
id: H2QNS5
db: uniprot

Complex (GDP/G-protein/ Sigma receptor/Enkephalin)
type: Complex
component stoichiometry: GDP s24 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: Enkephalin s27 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: Mu or Delta receptor s63 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: G protein s25 sa11 STOICHIOMETRY ID COMPLEX
component: GDP
component: G-protein
component: Enkephalin
component: Mu or Delta receptor
feature: COMPLEX BINDING FEATURE s56 a63 335
feature: COMPLEX BINDING FEATURE s56 a63 333
feature: COMPLEX BINDING FEATURE s56 a63 331
feature: COMPLEX BINDING FEATURE s56 a63 329
cellular location: cytosol

Enkephalin
type: Protein
entity reference: Enkephalin
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa13 336
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P50151 254
type: UnificationXref
id: P50151
db: uniprot

GDP s24 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot F7DL70 137
organism: Macaca mulatta

eco ECO:0000250 7
type: UnificationXref
id: ECO:0000250
db: eco

Enkephalin
type: Protein
entity reference: Enkephalin
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa9 344
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 4

uniprot O95721 65
type: UnificationXref
id: O95721
db: uniprot

uniprot F6UJE8 187
type: UnificationXref
id: F6UJE8
db: uniprot

uniprot F6YMH2 47
type: UnificationXref
id: F6YMH2
db: uniprot

uniprot O02495 60
type: UnificationXref
id: O02495
db: uniprot

Opioid proenkephalin pathway
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__GDP_G_protein__Sigma,_Mu,_Kappa_-_leu_Enkephalin-_met_Enkephalin-RIGHT__Complex__GDP_G_protein__Sigma_receptor_Enkephalin_-_re20
pathway component: STATE_TRANSITION_LEFT__K_PLUS__channel-RIGHT__K_PLUS__channel-_re11
pathway component: PHYSICAL_STIMULATION
pathway component: DISSOCIATION_LEFT__proenkephalin-RIGHT__met_Enkephalin-_peptide_E-_leu_Enkephalin-_peptide_F-_re1
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re3
pathway component: MODULATION
pathway component: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re12
pathway component: DISSOCIATION_LEFT__Complex__GDP_G_protein__Sigma_receptor_Enkephalin_-_GTP-RIGHT__Complex__GTP_G_protein_-_Complex__Sigma_receptor_Enkephalin_-_GDP-_re21
pathway component: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re4
pathway component: TRANSPORT_LEFT__met_Enkephalin-RIGHT__met_Enkephalin-_re2
pathway component: TRANSPORT_LEFT__leu_Enkephalin-RIGHT__leu_Enkephalin-_re8
xref: PANTHER Pathway P05915 1
comment: MODEL_NOTES=Panther Pathway: P05915 No pathway definition

Syntaxin 3A
type: ProteinReference
xref: uniprot Q6PHV0 101
xref: PTHR19957:SF34
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ERP8 206
organism: Ornithorhynchus anatinus

uniprot Q80SZ7 316
type: UnificationXref
id: Q80SZ7
db: uniprot

Syntaxin 3
type: ProteinReference
xref: uniprot F7EPG4 50
xref: PTHR19957:SF34
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6VPY1 190
organism: Ornithorhynchus anatinus

uniprot H2PYH8 11
type: UnificationXref
id: H2PYH8
db: uniprot

uniprot F7FD32 209
type: UnificationXref
id: F7FD32
db: uniprot

uniprot H2QMN4 223
type: UnificationXref
id: H2QMN4
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P36408 247
organism: Dictyostelium discoideum

uniprot F6TFY2 186
type: UnificationXref
id: F6TFY2
db: uniprot

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9W1I8 114
type: UnificationXref
id: Q9W1I8
db: uniprot

uniprot F7FXA9 211
type: UnificationXref
id: F7FXA9
db: uniprot

uniprot P04094 124
type: UnificationXref
id: P04094
db: uniprot

uniprot P20353 242
type: UnificationXref
id: P20353
db: uniprot