Oxytocin-neurophysin 1
type: DnaReference
xref: PTHR11681:SF2
organism: Rattus norvegicus

uniprot P01175 126
type: UnificationXref
id: P01175
db: uniprot

uniprot F6UJE8 193
type: UnificationXref
id: F6UJE8
db: uniprot

uniprot Q28H40 297
type: UnificationXref
id: Q28H40
db: uniprot

Neuronal synaptobrevin, isoform J
type: ProteinReference
xref: PTHR45701:SF3
xref: uniprot M9PE71 46
organism: Drosophila melanogaster

uniprot P01179 128
type: UnificationXref
id: P01179
db: uniprot

eco ECO:0000245 109
type: UnificationXref
id: ECO:0000245
db: eco

uniprot P59215 271
type: UnificationXref
id: P59215
db: uniprot

G protein subunit alpha i3
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot H2PZK9 226
organism: Pan troglodytes

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 3

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q5ZJ03 307
organism: Gallus gallus

PTHR10218:SF331
type: RelationshipXref
id: PTHR10218:SF331
db: PANTHER Family
relationship type: By Homology

Syntaxin-3
type: ProteinReference
xref: uniprot Q64704 91
xref: PTHR19957:SF34
organism: Mus musculus

ncbitaxon 6669 177
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot P63097 283
type: UnificationXref
id: P63097
db: uniprot

G protein subunit alpha i1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F1P977 183
organism: Canis lupus familiaris

Kappa Receptor s64 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Kappa Receptor
stoichiometric coefficient: 1.0

uniprot P35455 133
type: UnificationXref
id: P35455
db: uniprot

uniprot A5PEW5 16
type: UnificationXref
id: A5PEW5
db: uniprot

uniprot Q61011 308
type: UnificationXref
id: Q61011
db: uniprot

antidiuretic effects
type: Pathway

SNARE COMPLEX
type: Protein
entity reference: SNARE COMPLEX
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IFL6 154
organism: Bos taurus

uniprot P29829 255
type: UnificationXref
id: P29829
db: uniprot

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot Q08462 144
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63212 284
organism: Bos taurus

uniprot Q2KIP6 118
type: UnificationXref
id: Q2KIP6
db: uniprot

uniprot A0A2I3SR99 12
type: UnificationXref
id: A0A2I3SR99
db: uniprot

Vasopressin-neurophysin 2-copeptin
type: DnaReference
xref: PTHR11681:SF9
organism: Bos taurus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 52

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XYX9 35
xref: PTHR45701:SF6
organism: Monodelphis domestica

Uncharacterized protein
type: DnaReference
xref: PTHR11681:SF2
organism: Macaca mulatta

Oxytocin-neurophysin 1
type: DnaReference
xref: PTHR11681:SF2
organism: Bos taurus

uniprot A0A3Q1NGS8 151
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

Kappa-type opioid receptor
type: ProteinReference
xref: PTHR24229:SF1
xref: uniprot P33534 115
organism: Mus musculus

eco ECO:0000305 18
type: UnificationXref
id: ECO:0000305
db: eco

PTHR19305:SF14
type: RelationshipXref
id: PTHR19305:SF14
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 277
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 276
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 274
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 275
organism: Homo sapiens

PTHR10218:SF310
type: RelationshipXref
id: PTHR10218:SF310
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot P62881 279
organism: Mus musculus

ncbitaxon 6945 163
type: UnificationXref
id: 6945
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 278
organism: Mus musculus

uniprot H2Q3R5 42
type: UnificationXref
id: H2Q3R5
db: uniprot

Arginine vasopressin
type: ProteinReference
xref: uniprot F1PZS7 120
xref: PTHR11681:SF9
organism: Canis lupus familiaris

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot F6UFJ7 31
xref: PTHR19305:SF9
organism: Macaca mulatta

ncbitaxon 3702 101
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot F1PJE5 184
type: UnificationXref
id: F1PJE5
db: uniprot

uniprot A8X8S6 19
type: UnificationXref
id: A8X8S6
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 187

uniprot Q6PHV0 93
type: UnificationXref
id: Q6PHV0
db: uniprot

ncbitaxon 7955 88
type: UnificationXref
id: 7955
db: ncbitaxon

Gnai3 protein
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot A9JTC8 160
organism: Danio rerio

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot F6WNJ9 198
organism: Xenopus tropicalis

uniprot F6UFJ7 31
type: UnificationXref
id: F6UFJ7
db: uniprot

ncbitaxon 9615 22
type: UnificationXref
id: 9615
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 273
organism: Bos taurus

uniprot P63219 291
type: UnificationXref
id: P63219
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot F1LQT1 135
organism: Rattus norvegicus

uniprot P63213 285
type: UnificationXref
id: P63213
db: uniprot

uniprot P62874 276
type: UnificationXref
id: P62874
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot F7CTP1 208
organism: Macaca mulatta

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60879 66
organism: Mus musculus

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60878 64
organism: Gallus gallus

Putative synaptobrevin homologue SNC1/2 (Eurofung)
type: ProteinReference
xref: uniprot Q5ASG1 84
organism: Emericella nidulans

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60877 63
organism: Macaca mulatta

Guanine nucleotide binding protein, beta 3
type: ProteinReference
xref: uniprot Q5XGD8 306
organism: Xenopus tropicalis

G protein s21 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-protein
stoichiometric coefficient: 1.0

uniprot O60262 239
type: UnificationXref
id: O60262
db: uniprot

uniprot P50154 266
type: UnificationXref
id: P50154
db: uniprot

uniprot Q9SD96 104
type: UnificationXref
id: Q9SD96
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 13

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60880 67
organism: Homo sapiens

prepropressophysin
type: RnaRegion
entity reference: prepropressophysin
cellular location: nucleus
comment: SPECIES_TYPE=RNA

magnocellular cells in hypothalamus c4
type: CellularLocationVocabulary
comment: magnocellular cells in hypothalamus

Guanine nucleotide-binding protein G(O) subunit alpha 1
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot E9H7Z0 178
organism: Daphnia pulex

uniprot Q62442 89
type: UnificationXref
id: Q62442
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: uniprot Q2KJD2 82
xref: PTHR45701:SF6
organism: Bos taurus

uniprot F6SED9 27
type: UnificationXref
id: F6SED9
db: uniprot

uniprot E2RJB3 175
type: UnificationXref
id: E2RJB3
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63044 73
organism: Mus musculus

uniprot Q9HAV0 336
type: UnificationXref
id: Q9HAV0
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63045 74
organism: Rattus norvegicus

uniprot H2QJV1 124
type: UnificationXref
id: H2QJV1
db: uniprot

Synaptobrevin-1
type: ProteinReference
xref: uniprot O02495 50
xref: PTHR45701:SF3
organism: Caenorhabditis elegans

uniprot Q08849 76
type: UnificationXref
id: Q08849
db: uniprot

preprodynorphin
type: DnaRegion
entity reference: preprodynorphin
cellular location: nucleus
comment: SPECIES_TYPE=GENE

Guanine nucleotide-binding protein subunit beta-5a
type: ProteinReference
xref: uniprot A1L271 153
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZSF0 166
organism: Branchiostoma floridae

uniprot F1MYW8 181
type: UnificationXref
id: F1MYW8
db: uniprot

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot Q6TNT8 320
organism: Danio rerio

HETERODIMER_ASSOCIATION_LEFT__dynorphin-_Complex__GDP_G_protein__Sigma_Receptor_-RIGHT__Complex__GDP_G_protein__Sigma_Receptor_endorphins__morphine_like__-_re5
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 379
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 378
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 377
left: Complex (GDP/G-protein/ Sigma Receptor)
left: dynorphin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GDP/G-protein/ Sigma Receptor/endorphins (morphine like))

Vesicle-associated membrane protein 8 (Endobrevin)
type: ProteinReference
xref: uniprot Q7ZUC1 95
xref: PTHR45701:SF7
organism: Danio rerio

Vasotocin-neurophysin VT
type: DnaReference
xref: PTHR11681:SF9
organism: Gallus gallus

uniprot C3XY80 164
type: UnificationXref
id: C3XY80
db: uniprot

uniprot F6SSS3 191
type: UnificationXref
id: F6SSS3
db: uniprot

uniprot Q9BV40 98
type: UnificationXref
id: Q9BV40
db: uniprot

dynorphin
type: ProteinReference
xref: P06003
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: dynorphinSynonym: Synonym not specifiedAccession: P06003
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.dynorphin
member entity reference: Beta-neoendorphin-dynorphin
member entity reference: Proenkephalin-B
member entity reference: PDYN isoform 1

ncbitaxon 9598 13
type: UnificationXref
id: 9598
db: ncbitaxon

G protein s7 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-protein
stoichiometric coefficient: 1.0

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63027 72
organism: Homo sapiens

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63026 71
xref: PTHR45701:SF5
organism: Bos taurus

uniprot E2R2S8 171
type: UnificationXref
id: E2R2S8
db: uniprot

uniprot Q0V7N0 77
type: UnificationXref
id: Q0V7N0
db: uniprot

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 382
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 383
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

PARTICIPANT STOICHIOMETRY re4 380
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63024 68
organism: Mus musculus

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63025 69
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re4 381
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 188
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R9G5 172
organism: Canis lupus familiaris

Oxytocin
type: ProteinReference
xref: uniprot F1QC27 121
organism: Danio rerio

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot O70404 55
xref: PTHR45701:SF7
organism: Mus musculus

VAMP2 isoform 3
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot H2RCB8 45
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot O14775 238
organism: Homo sapiens

uniprot C3ZSF0 166
type: UnificationXref
id: C3ZSF0
db: uniprot

uniprot P63025 69
type: UnificationXref
id: P63025
db: uniprot

Vesicle associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot F6Z5I2 37
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot F6RIM7 190
organism: Monodelphis domestica

uniprot O14775 238
type: UnificationXref
id: O14775
db: uniprot

uniprot F6PVT7 189
type: UnificationXref
id: F6PVT7
db: uniprot

Kappa Receptor s63 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Kappa Receptor
stoichiometric coefficient: 1.0

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 171
organism: Canis lupus familiaris

uniprot O70404 55
type: UnificationXref
id: O70404
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R2S3 170
organism: Canis lupus familiaris

uniprot F7CXD0 209
type: UnificationXref
id: F7CXD0
db: uniprot

uniprot P33328 61
type: UnificationXref
id: P33328
db: uniprot

uniprot A0A2I3TFM8 149
type: UnificationXref
id: A0A2I3TFM8
db: uniprot

uniprot H2PZK9 226
type: UnificationXref
id: H2PZK9
db: uniprot

uniprot F6XHP0 199
type: UnificationXref
id: F6XHP0
db: uniprot

GDP s30 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot O09044 51
type: UnificationXref
id: O09044
db: uniprot

uniprot P63024 68
type: UnificationXref
id: P63024
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 7

uniprot F7EBE7 211
type: UnificationXref
id: F7EBE7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7AXI7 122
organism: Macaca mulatta

uniprot Q29450 145
type: UnificationXref
id: Q29450
db: uniprot

Proenkephalin-B
type: DnaReference
xref: PTHR11438:SF4
organism: Homo sapiens

G-protein
type: Protein
entity reference: G-protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa30 361
cellular location: cell
comment: SPECIES_TYPE=PROTEIN

G protein subunit alpha i2
type: ProteinReference
xref: uniprot H2QMN4 230
xref: PTHR10218:SF73
organism: Pan troglodytes

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__dynorphin-RIGHT__dynorphin-_re7
control type: ACTIVATION
controller: SNARE COMPLEX

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot O95721 56
organism: Homo sapiens

ncbitaxon 9544 7
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot P04899 241
type: UnificationXref
id: P04899
db: uniprot

uniprot F7GQC5 221
type: UnificationXref
id: F7GQC5
db: uniprot

STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 381
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 380
left: AC
interaction type: STATE_TRANSITION
right: AC

uniprot Q92356 96
type: UnificationXref
id: Q92356
db: uniprot

ncbitaxon 7719 331
type: UnificationXref
id: 7719
db: ncbitaxon

DISSOCIATION
type: RelationshipTypeVocabulary

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot Q9DC51 335
organism: Mus musculus

prepropressophysin
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.prepropressophysin
comment: ENTITY_REFERENCE_NOTES=Long Name: prepropressophysinSynonym: Synonym not specifiedAccession: G06048

uniprot Q13277 78
type: UnificationXref
id: Q13277
db: uniprot

uniprot Q9UK08 338
type: UnificationXref
id: Q9UK08
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50150 263
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot P50151 264
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LYB4 14
xref: PTHR19957:SF34
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot P50154 266
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50153 265
organism: Mus musculus

uniprot P51875 267
type: UnificationXref
id: P51875
db: uniprot

uniprot P63096 282
type: UnificationXref
id: P63096
db: uniprot

G protein subunit alpha i1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F7FSE3 216
organism: Ornithorhynchus anatinus

uniprot K7AE17 235
type: UnificationXref
id: K7AE17
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QDW1 6
xref: PTHR19957:SF34
organism: Macaca mulatta

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P50146 262
organism: Gallus gallus

uniprot P23763 58
type: UnificationXref
id: P23763
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SED9 27
xref: PTHR19957:SF34
organism: Monodelphis domestica

AC
type: Protein
entity reference: AC
cellular location: cell
comment: SPECIES_TYPE=PROTEIN

uniprot A5PKD6 156
type: UnificationXref
id: A5PKD6
db: uniprot

uniprot P62873 275
type: UnificationXref
id: P62873
db: uniprot

G protein alpha subunit Gi isoform X2
type: ProteinReference
xref: PTHR10218:SF310
xref: uniprot Q8WSS1 330
organism: Ciona intestinalis

uniprot F7FSE3 216
type: UnificationXref
id: F7FSE3
db: uniprot

uniprot A0A3Q1LYB4 14
type: UnificationXref
id: A0A3Q1LYB4
db: uniprot

preprodynorphin
type: RnaRegion
entity reference: preprodynorphin
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YMH2 36
xref: PTHR45701:SF6
organism: Macaca mulatta

STATE_TRANSITION
type: RelationshipTypeVocabulary

KNOWN_TRANSITION_OMITTED_LEFT__prodynorphin-RIGHT__dynorphin-_re8
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 369
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 368
left: prodynorphin
interaction type: KNOWN_TRANSITION_OMITTED
right: dynorphin

uniprot F6ZIZ9 203
type: UnificationXref
id: F6ZIZ9
db: uniprot

Arginine vasopressin (Fragment)
type: ProteinReference
xref: uniprot F8W5D0 123
organism: Danio rerio

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re3
controller: AC

PTHR10218:SF302
type: RelationshipXref
id: PTHR10218:SF302
db: PANTHER Family
relationship type: By Homology

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot K7ADQ0 140
organism: Pan troglodytes

Oxytocin-neurophysin 1
type: ProteinReference
xref: uniprot P01175 126
organism: Bos taurus

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q9BV40 98
xref: PTHR45701:SF7
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V6P8 223
organism: Rattus norvegicus

uniprot Q5ZJ03 307
type: UnificationXref
id: Q5ZJ03
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot F7A943 38
organism: Monodelphis domestica

Oxytocin-neurophysin 1
type: ProteinReference
xref: uniprot P01178 127
organism: Homo sapiens

Oxytocin-neurophysin 1
type: ProteinReference
xref: uniprot P01179 128
organism: Rattus norvegicus

Soluble NSF attachment protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot P83351 75
organism: Caenorhabditis elegans

Proenkephalin-B
type: DnaReference
xref: PTHR11438:SF4
organism: Mus musculus

uniprot E2QUL2 21
type: UnificationXref
id: E2QUL2
db: uniprot

uniprot H2Q3W7 228
type: UnificationXref
id: H2Q3W7
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot H2Q9G5 229
organism: Pan troglodytes

Kappa Receptor
type: ProteinReference
xref: P05998
standard name: opioid receptor, kappa
comment: ENTITY_REFERENCE_NOTES= Long Name: opioid receptor, kappaSynonym: OPRKAccession: P05998
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.Kappa Receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Kappa-type opioid receptor
member entity reference: Opioid receptor kappa 1

Vasopressin-neurophysin 2-copeptin
type: ProteinReference
xref: PTHR11681:SF9
xref: uniprot P01185 129
organism: Homo sapiens

Vasopressin-neurophysin 2-copeptin
type: ProteinReference
xref: uniprot P01186 130
xref: PTHR11681:SF9
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63219 291
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 290
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63217 289
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63216 288
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 287
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63214 286
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63213 285
organism: Mus musculus

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 20

ncbitaxon 7165 26
type: UnificationXref
id: 7165
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q15KE4 294
organism: Danio rerio

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 17

uniprot P35454 132
type: UnificationXref
id: P35454
db: uniprot

uniprot F6PGC8 188
type: UnificationXref
id: F6PGC8
db: uniprot

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot P29829 255
organism: Drosophila melanogaster

G protein subunit alpha i1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot A0A2I3S4R3 148
organism: Pan troglodytes

uniprot P11017 246
type: UnificationXref
id: P11017
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7F580 214
organism: Macaca mulatta

prepropressophysin
type: DnaRegionReference
member entity reference: Vasopressin-neurophysin 2-copeptin
member entity reference: Oxytocin-neurophysin 1
member entity reference: Arginine vasopressin
member entity reference: OXT isoform 1
member entity reference: AVP isoform 1
member entity reference: Oxytocin
member entity reference: Arginine vasopressin (Fragment)
member entity reference: Vasotocin-neurophysin VT
member entity reference: Uncharacterized protein
xref: G06050
comment: ENTITY_REFERENCE_NOTES=Long Name: prepropressophysinSynonym: Synonym not specifiedAccession: G06050
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.prepropressophysin

AC
type: Protein
entity reference: AC
feature: ACTIVE 147
cellular location: cell
comment: SPECIES_TYPE=PROTEIN

analgesic pain relief
type: Pathway

G protein subunit alpha o1
type: ProteinReference
xref: uniprot A0A2I3TFM8 149
xref: PTHR10218:SF302
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot Q9CXP8 333
organism: Mus musculus

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P04897 240
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P59215 271
organism: Rattus norvegicus

uniprot P62881 279
type: UnificationXref
id: P62881
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RGI5 173
organism: Canis lupus familiaris

vasopressin
type: ProteinReference
xref: P06000
comment: ENTITY_REFERENCE_NOTES=Long Name: vasopressinSynonym: ADH,Long Name: vasopressin,antidiuretic hormoneAccession: P06000
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.vasopressin
member entity reference: Vasopressin-neurophysin 2-copeptin
member entity reference: Oxytocin-neurophysin 1
member entity reference: Arginine vasopressin (Fragment)
member entity reference: Vasotocin-neurophysin VT
member entity reference: OXT isoform 1
member entity reference: Arginine vasopressin
member entity reference: Uncharacterized protein
member entity reference: AVP isoform 1
member entity reference: Oxytocin

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P04899 241
organism: Homo sapiens

uniprot Q0VFC4 292
type: UnificationXref
id: Q0VFC4
db: uniprot

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: uniprot P51875 267
xref: PTHR10218:SF302
organism: Caenorhabditis elegans

uniprot O95721 56
type: UnificationXref
id: O95721
db: uniprot

G protein alpha o subunit
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P16378 247
organism: Drosophila melanogaster

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: antidiuretic effects
controller: cAMP

Synaptobrevin
type: ProteinReference
xref: PTHR45701:SF10
xref: uniprot P18489 57
organism: Drosophila melanogaster

uniprot P20353 252
type: UnificationXref
id: P20353
db: uniprot

uniprot Q9Z2P6 108
type: UnificationXref
id: Q9Z2P6
db: uniprot

uniprot A4IGZ2 155
type: UnificationXref
id: A4IGZ2
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

SNAP25 homologous protein SNAP29
type: ProteinReference
xref: uniprot Q9SD96 104
organism: Arabidopsis thaliana

uniprot A0A1D5QIS2 10
type: UnificationXref
id: A0A1D5QIS2
db: uniprot

uniprot P60880 67
type: UnificationXref
id: P60880
db: uniprot

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 158

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 305

uniprot Q64704 91
type: UnificationXref
id: Q64704
db: uniprot

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P17343 249
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P18872 251
organism: Mus musculus

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 109

uniprot P54311 269
type: UnificationXref
id: P54311
db: uniprot

uniprot F1PRG8 24
type: UnificationXref
id: F1PRG8
db: uniprot

PTHR11681:SF9
type: RelationshipXref
id: PTHR11681:SF9
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3SZ98 299
organism: Bos taurus

Synaptosomal-associated protein 25-A
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q5TZ66 87
organism: Danio rerio

uniprot A7EDU2 157
type: UnificationXref
id: A7EDU2
db: uniprot

Vasopressin-neurophysin 2-copeptin
type: DnaReference
xref: PTHR11681:SF9
organism: Mus musculus

PTHR11681:SF2
type: RelationshipXref
id: PTHR11681:SF2
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__prepropressophysin-RIGHT__prepropressophysin-_re12
control type: ACTIVATION
controller: dehydration or salt loading stress

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot A5PEW5 16
organism: Caenorhabditis elegans

uniprot P62880 278
type: UnificationXref
id: P62880
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 165

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6SSS3 191
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q1D9 227
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6W548 197
organism: Macaca mulatta

uniprot P18489 57
type: UnificationXref
id: P18489
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 8

GNAI2 protein
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot A7MBH9 159
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P52287 268
organism: Rattus norvegicus

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F6UBJ8 29
xref: PTHR19305:SF4
organism: Xenopus tropicalis

Synaptobrevin homolog 2
type: ProteinReference
xref: uniprot P33328 61
organism: Saccharomyces cerevisiae

uniprot D3ZLD6 167
type: UnificationXref
id: D3ZLD6
db: uniprot

uniprot H2Q995 43
type: UnificationXref
id: H2Q995
db: uniprot

uniprot O35417 112
type: UnificationXref
id: O35417
db: uniprot

uniprot F7GI54 220
type: UnificationXref
id: F7GI54
db: uniprot

cell
type: CellularLocationVocabulary
xref: go GO:0005623 4

Syntaxin-3
type: ProteinReference
xref: uniprot Q13277 78
xref: PTHR19957:SF34
organism: Homo sapiens

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 28

uniprot P62872 274
type: UnificationXref
id: P62872
db: uniprot

uniprot Q5BJ11 302
type: UnificationXref
id: Q5BJ11
db: uniprot

ncbitaxon 227321 85
type: UnificationXref
id: 227321
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7AE17 235
organism: Pan troglodytes

uniprot Q9W1I8 106
type: UnificationXref
id: Q9W1I8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 168
organism: Gallus gallus

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 331

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F6VUT7 33
xref: PTHR19305:SF5
organism: Ornithorhynchus anatinus

Synaptosomal-associated protein 23
type: ProteinReference
xref: uniprot O00161 48
xref: PTHR19305:SF4
organism: Homo sapiens

uniprot J9P702 234
type: UnificationXref
id: J9P702
db: uniprot

uniprot H2QJV2 125
type: UnificationXref
id: H2QJV2
db: uniprot

uniprot P63217 289
type: UnificationXref
id: P63217
db: uniprot

TRANSCRIPTION
type: InteractionVocabulary

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot B2RSH2 161
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 218
organism: Monodelphis domestica

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot A0A1D5RHE7 134
organism: Macaca mulatta

Vesicle associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot F1PRG8 24
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P08752 242
organism: Mus musculus

uniprot F1P977 183
type: UnificationXref
id: F1P977
db: uniprot

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot P08754 244
organism: Homo sapiens

Guanine nucleotide-binding protein G(K) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot F6VL43 195
organism: Macaca mulatta

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot P08753 243
organism: Rattus norvegicus

Proenkephalin-B
type: ProteinReference
xref: PTHR11438:SF4
xref: uniprot P01213 113
organism: Homo sapiens

AVP isoform 1
type: DnaReference
xref: PTHR11681:SF9
organism: Pan troglodytes

uniprot F7G3J2 218
type: UnificationXref
id: F7G3J2
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot Q9ERB0 99
xref: PTHR19305:SF9
organism: Mus musculus

uniprot G5EEN8 41
type: UnificationXref
id: G5EEN8
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DF43 311
organism: Xenopus tropicalis

uniprot A0A3Q1LXY0 119
type: UnificationXref
id: A0A3Q1LXY0
db: uniprot

SNARE COMPLEX
type: ProteinReference
xref: P05996
standard name: SNARE Complex
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: SNARE COMPLEXSynonym: Long Name: SNARE COMPLEXAccession: P05996
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.SNARE COMPLEX
member entity reference: Uncharacterized protein
member entity reference: Synaptosomal-associated protein
member entity reference: VAMP2 isoform 3
member entity reference: Synaptobrevin-1
member entity reference: Vesicle-associated membrane protein 2
member entity reference: Synaptosomal-associated protein 29
member entity reference: Vesicle associated membrane protein 1
member entity reference: Vesicle-associated membrane protein 3
member entity reference: Synaptosomal-associated protein 25
member entity reference: Vesicle-associated membrane protein 1
member entity reference: Synaptosomal-associated protein 23
member entity reference: Vesicle-associated membrane protein 8 (Endobrevin)
member entity reference: Syntaxin-3
member entity reference: Vesicle associated membrane protein 8
member entity reference: Soluble NSF attachment protein 29
member entity reference: Vesicle-associated membrane protein 8
member entity reference: Putative synaptobrevin homologue SNC1/2 (Eurofung)
member entity reference: SNAP25 homologous protein SNAP29
member entity reference: VAMP3 isoform 1
member entity reference: Synaptobrevin
member entity reference: LD03592p
member entity reference: SNAP29 isoform 1
member entity reference: SNAP25 homologous protein SNAP33
member entity reference: Synaptobrevin homolog 1
member entity reference: Synaptosomal-associated protein 25-B
member entity reference: Syntaxin 3
member entity reference: Synaptobrevin homolog 2
member entity reference: Putative SNAP25 homologous protein SNAP30
member entity reference: t-SNARE protein aex-4
member entity reference: Neuronal synaptobrevin, isoform J

uniprot Q7Q6D2 322
type: UnificationXref
id: Q7Q6D2
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 336
organism: Homo sapiens

ncbitaxon 7739 165
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot H2QMN4 230
type: UnificationXref
id: H2QMN4
db: uniprot

uniprot O14610 237
type: UnificationXref
id: O14610
db: uniprot

Vasopressin-neurophysin 2-copeptin
type: DnaReference
xref: PTHR11681:SF9
organism: Homo sapiens

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot Q10282 293
organism: Schizosaccharomyces pombe

PDYN isoform 1
type: ProteinReference
xref: PTHR11438:SF4
xref: uniprot A0A2J8MS47 110
organism: Pan troglodytes

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P38400 259
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RJB3 175
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY re3 382
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 101

PARTICIPANT STOICHIOMETRY re3 383
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

OXT isoform 1
type: DnaReference
xref: PTHR11681:SF2
organism: Pan troglodytes

uniprot Q61017 310
type: UnificationXref
id: Q61017
db: uniprot

uniprot Q6TNT8 320
type: UnificationXref
id: Q6TNT8
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P18851 250
organism: Saccharomyces cerevisiae

Guanine nucleotide-binding protein subunit beta-5b
type: ProteinReference
xref: uniprot Q6PBY0 317
organism: Danio rerio

uniprot O02495 50
type: UnificationXref
id: O02495
db: uniprot

Gbeta5
type: ProteinReference
xref: uniprot Q9W3J1 339
organism: Drosophila melanogaster

PTHR45701:SF6
type: RelationshipXref
id: PTHR45701:SF6
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF7
type: RelationshipXref
id: PTHR45701:SF7
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1PJE5 184
organism: Canis lupus familiaris

G protein subunit gamma 5
type: ProteinReference
xref: uniprot H2PZA6 225
organism: Pan troglodytes

PTHR45701:SF5
type: RelationshipXref
id: PTHR45701:SF5
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF3
type: RelationshipXref
id: PTHR45701:SF3
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF1
type: RelationshipXref
id: PTHR45701:SF1
db: PANTHER Family
relationship type: By Homology

uniprot P30671 256
type: UnificationXref
id: P30671
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot Q9UK08 338
organism: Homo sapiens

PDYN isoform 1
type: DnaReference
xref: PTHR11438:SF4
organism: Pan troglodytes

uniprot Q9VH76 105
type: UnificationXref
id: Q9VH76
db: uniprot

uniprot Q3ZCA7 300
type: UnificationXref
id: Q3ZCA7
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 88

uniprot F6V461 194
type: UnificationXref
id: F6V461
db: uniprot

uniprot Q7SZZ5 94
type: UnificationXref
id: Q7SZZ5
db: uniprot

uniprot H2Q1D9 227
type: UnificationXref
id: H2Q1D9
db: uniprot

Syntaxin-3
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot Q08849 76
organism: Rattus norvegicus

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 150
organism: Pan troglodytes

uniprot J9P639 114
type: UnificationXref
id: J9P639
db: uniprot

dynorphin
type: Protein
entity reference: dynorphin
feature: COMPLEX PARTICIPANT BINDING FEATURE s59 sa28 345
cellular location: cell
comment: SPECIES_TYPE=PROTEIN

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa29 359
cellular location: cell
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q17QQ3 80
xref: PTHR19305:SF5
organism: Bos taurus

uniprot Q5TZ66 87
type: UnificationXref
id: Q5TZ66
db: uniprot

uniprot F7BB02 206
type: UnificationXref
id: F7BB02
db: uniprot

P05999
type: UnificationXref
id: P05999
db: PANTHER Pathway Component

uniprot Q90Z40 332
type: UnificationXref
id: Q90Z40
db: uniprot

uniprot P50151 264
type: UnificationXref
id: P50151
db: uniprot

Vasopressin-neurophysin 2-copeptin
type: DnaReference
xref: PTHR11681:SF9
organism: Rattus norvegicus

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot Q9N0Y0 102
organism: Macaca mulatta

uniprot F7CTP1 208
type: UnificationXref
id: F7CTP1
db: uniprot

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot P36975 62
organism: Drosophila melanogaster

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q3T0Y8 83
organism: Bos taurus

ncbitaxon 44689 258
type: UnificationXref
id: 44689
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 202
organism: Monodelphis domestica

G-protein
type: ProteinReference
xref: P06002
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.G-protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: G-proteinSynonym: Synonym not specifiedAccession: P06002
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
member entity reference: THO complex subunit, putative
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Guanine nucleotide-binding protein subunit beta-2
member entity reference: G protein subunit alpha i3
member entity reference: Uncharacterized protein
member entity reference: AGAP005912-PA
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
member entity reference: Guanine nucleotide-binding protein G(k) subunit alpha
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
member entity reference: Guanine nucleotide-binding protein subunit beta-5a
member entity reference: Guanine nucleotide-binding protein G(K) subunit alpha
member entity reference: Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
member entity reference: Guanine nucleotide-binding protein subunit beta-4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2b
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
member entity reference: Gbeta5
member entity reference: Guanine nucleotide-binding protein (G protein), beta 5
member entity reference: G protein subunit gamma 5
member entity reference: G protein alpha i subunit
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
member entity reference: Guanine nucleotide-binding protein beta subunit
member entity reference: G protein subunit beta 5
member entity reference: G protein subunit alpha o1
member entity reference: AGAP005773-PA
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: G protein subunit beta 4
member entity reference: G protein subunit beta 3
member entity reference: Gi alpha subunit
member entity reference: GNAI2 protein
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: G protein subunit beta 1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: Guanine nucleotide-binding protein subunit beta-1

Vesicle-associated membrane protein 3
type: ProteinReference
xref: uniprot Q15836 79
xref: PTHR45701:SF6
organism: Homo sapiens

uniprot Q63666 90
type: UnificationXref
id: Q63666
db: uniprot

uniprot F7DL70 139
type: UnificationXref
id: F7DL70
db: uniprot

uniprot P63026 71
type: UnificationXref
id: P63026
db: uniprot

uniprot Q15KE4 294
type: UnificationXref
id: Q15KE4
db: uniprot

uniprot A4IFL6 154
type: UnificationXref
id: A4IFL6
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P63097 283
organism: Bos taurus

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P63096 282
organism: Homo sapiens

provasopressin
type: Protein
entity reference: provasopressin
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot Q17QQ3 80
type: UnificationXref
id: Q17QQ3
db: uniprot

Synaptosomal-associated protein 25-B
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q6PC54 92
organism: Danio rerio

ATP
type: SmallMolecule
cellular location: cell
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot O44419 53
organism: Strongylocentrotus purpuratus

exocytic vesicle
type: CellularLocationVocabulary
xref: GO GO:0070382 5

Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
type: ProteinReference
xref: uniprot Q6DH55 313
organism: Danio rerio

PARTICIPANT STOICHIOMETRY re1 387
type: Stoichiometry
physical entity: vasopressin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 386
type: Stoichiometry
physical entity: vasopressin
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6TFY2 192
organism: Macaca mulatta

uniprot Q7Q6D3 323
type: UnificationXref
id: Q7Q6D3
db: uniprot

uniprot A0A1D5QYR9 11
type: UnificationXref
id: A0A1D5QYR9
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q62442 89
organism: Mus musculus

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 70

uniprot Q6PH57 318
type: UnificationXref
id: Q6PH57
db: uniprot

uniprot H2QLA1 44
type: UnificationXref
id: H2QLA1
db: uniprot

uniprot Q9WUF4 107
type: UnificationXref
id: Q9WUF4
db: uniprot

uniprot H2QNS5 231
type: UnificationXref
id: H2QNS5
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

uniprot P63214 286
type: UnificationXref
id: P63214
db: uniprot

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 177

INHIBITION
type: RelationshipTypeVocabulary

GTP
type: SmallMolecule
cellular location: cell
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot E1C795 169
type: UnificationXref
id: E1C795
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63078 281
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 280
organism: Rattus norvegicus

Kappa Receptor
type: Protein
entity reference: Kappa Receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s64 sa25 355
cellular location: cell
comment: SPECIES_TYPE=PROTEIN

uniprot P63215 287
type: UnificationXref
id: P63215
db: uniprot

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P09471 245
organism: Homo sapiens

uniprot F6WNJ9 198
type: UnificationXref
id: F6WNJ9
db: uniprot

uniprot A7MBH9 159
type: UnificationXref
id: A7MBH9
db: uniprot

LD03592p
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9W1I8 106
organism: Drosophila melanogaster

uniprot P49177 261
type: UnificationXref
id: P49177
db: uniprot

uniprot R4GKD1 340
type: UnificationXref
id: R4GKD1
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 270
organism: Rattus norvegicus

uniprot E2R9G5 172
type: UnificationXref
id: E2R9G5
db: uniprot

uniprot P16520 248
type: UnificationXref
id: P16520
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 269
organism: Rattus norvegicus

Putative SNAP25 homologous protein SNAP30
type: ProteinReference
xref: uniprot Q9LMG8 100
organism: Arabidopsis thaliana

uniprot Q20636 295
type: UnificationXref
id: Q20636
db: uniprot

uniprot P08754 244
type: UnificationXref
id: P08754
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 210
organism: Ornithorhynchus anatinus

uniprot M9PE71 46
type: UnificationXref
id: M9PE71
db: uniprot

ncbitaxon 5786 180
type: UnificationXref
id: 5786
db: ncbitaxon

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q0V7N0 77
organism: Bos taurus

Adenylate cyclase
type: ProteinReference
xref: uniprot F6V001 137
xref: PTHR45627:SF6
organism: Monodelphis domestica

uniprot P50153 265
type: UnificationXref
id: P50153
db: uniprot

Vasopressin-neurophysin 2-copeptin
type: ProteinReference
xref: uniprot P35455 133
xref: PTHR11681:SF9
organism: Mus musculus

G06050
type: UnificationXref
id: G06050
db: PANTHER Pathway Component

Oxytocin-neurophysin 1
type: ProteinReference
xref: uniprot P35454 132
organism: Mus musculus

uniprot P36408 257
type: UnificationXref
id: P36408
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 318
organism: Danio rerio

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot Q7T3D3 326
organism: Danio rerio

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot F1MJV4 136
organism: Bos taurus

uniprot P26769 141
type: UnificationXref
id: P26769
db: uniprot

uniprot F6Y3N2 201
type: UnificationXref
id: F6Y3N2
db: uniprot

G06047
type: UnificationXref
id: G06047
db: PANTHER Pathway Component

uniprot Q5BH99 301
type: UnificationXref
id: Q5BH99
db: uniprot

uniprot P62879 277
type: UnificationXref
id: P62879
db: uniprot

uniprot H2QZN8 232
type: UnificationXref
id: H2QZN8
db: uniprot

TRANSPORT_LEFT__dynorphin-RIGHT__dynorphin-_re7
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 370
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 371
left: dynorphin
interaction type: TRANSPORT
right: dynorphin

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 180

PARTICIPANT STOICHIOMETRY re10 365
type: Stoichiometry
physical entity: vasopressin
stoichiometric coefficient: 1.0

uniprot P52287 268
type: UnificationXref
id: P52287
db: uniprot

PARTICIPANT STOICHIOMETRY re10 364
type: Stoichiometry
physical entity: provasopressin
stoichiometric coefficient: 1.0

uniprot P01213 113
type: UnificationXref
id: P01213
db: uniprot

Complex (GTP/G-protein)
type: Complex
component stoichiometry: G protein s7 sa22 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s6 sa21 STOICHIOMETRY ID COMPLEX
component: G-protein
component: GTP
feature: COMPLEX BINDING FEATURE s22 csa1 348
feature: COMPLEX BINDING FEATURE s22 csa1 346
feature: ACTIVE 147
cellular location: cell

uniprot P41145 117
type: UnificationXref
id: P41145
db: uniprot

PTHR19957:SF34
type: RelationshipXref
id: PTHR19957:SF34
db: PANTHER Family
relationship type: By Homology

uniprot F7FXA9 217
type: UnificationXref
id: F7FXA9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot A0A1D5QIS2 10
organism: Macaca mulatta

uniprot P33534 115
type: UnificationXref
id: P33534
db: uniprot

uniprot F7ES96 213
type: UnificationXref
id: F7ES96
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re4
control type: INHIBITION
controller: Complex (GTP/G-protein)

DISSOCIATION_LEFT__GTP-_Complex__GDP_G_protein__Sigma_Receptor_endorphins__morphine_like__-RIGHT__GDP-_Complex__GTP_G_protein_-_Complex__Sigma_Receptor_endorphins__morphine_like__-_re6
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 376
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 372
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 373
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 374
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 375
left: Complex (GDP/G-protein/ Sigma Receptor/endorphins (morphine like))
left: GTP
interaction type: DISSOCIATION
right: Complex (GTP/G-protein)
right: Complex (Sigma Receptor/endorphins (morphine like))
right: GDP

PTHR11438:SF4
type: RelationshipXref
id: PTHR11438:SF4
db: PANTHER Family
relationship type: By Homology

uniprot P29387 254
type: UnificationXref
id: P29387
db: uniprot

AGAP005773-PA
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot A0NEH6 152
organism: Anopheles gambiae

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot Q7Q6E0 325
type: UnificationXref
id: Q7Q6E0
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot H2Q995 43
xref: PTHR19305:SF4
organism: Pan troglodytes

uniprot Q08462 144
type: UnificationXref
id: Q08462
db: uniprot

uniprot Q7PXP3 321
type: UnificationXref
id: Q7PXP3
db: uniprot

uniprot A0A1D5QDW1 6
type: UnificationXref
id: A0A1D5QDW1
db: uniprot

Guanine nucleotide-binding protein (G protein), beta 5
type: ProteinReference
xref: uniprot F7EBE7 211
organism: Xenopus tropicalis

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6V461 194
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P16520 248
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P59768 272
organism: Homo sapiens

uniprot F6TFY2 192
type: UnificationXref
id: F6TFY2
db: uniprot

ncbitaxon 10090 52
type: UnificationXref
id: 10090
db: ncbitaxon

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 85

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6PBR4 316
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DGZ5 312
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot J9P702 234
organism: Canis lupus familiaris

uniprot P51829 143
type: UnificationXref
id: P51829
db: uniprot

uniprot F6YMH2 36
type: UnificationXref
id: F6YMH2
db: uniprot

uniprot B7Q3T6 162
type: UnificationXref
id: B7Q3T6
db: uniprot

uniprot Q5KI86 304
type: UnificationXref
id: Q5KI86
db: uniprot

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot A0A2I3SR99 12
xref: PTHR45701:SF7
organism: Pan troglodytes

uniprot H2R3A6 233
type: UnificationXref
id: H2R3A6
db: uniprot

uniprot P01185 129
type: UnificationXref
id: P01185
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot A0A1D5QYR9 11
organism: Macaca mulatta

uniprot F1MJV4 136
type: UnificationXref
id: F1MJV4
db: uniprot

P05997
type: UnificationXref
id: P05997
db: PANTHER Pathway Component

G protein s33 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-protein
stoichiometric coefficient: 1.0

P05998
type: UnificationXref
id: P05998
db: PANTHER Pathway Component

P05996
type: UnificationXref
id: P05996
db: PANTHER Pathway Component

Gi alpha subunit
type: ProteinReference
xref: PTHR10218:SF310
xref: uniprot C3XY80 164
organism: Branchiostoma floridae

uniprot F2Z3T8 185
type: UnificationXref
id: F2Z3T8
db: uniprot

Vasotocin-neurophysin VT
type: ProteinReference
xref: uniprot P24787 131
xref: PTHR11681:SF9
organism: Gallus gallus

uniprot F7A943 38
type: UnificationXref
id: F7A943
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot F7FXA9 217
organism: Macaca mulatta

uniprot P63212 284
type: UnificationXref
id: P63212
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2b
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot X1WDQ5 341
organism: Danio rerio

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot P29387 254
organism: Mus musculus

PANTHER Pathway P05916 1
type: UnificationXref
id: P05916
db: PANTHER Pathway

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot F5HMS4 25
organism: Anopheles gambiae

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QZN8 232
organism: Pan troglodytes

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 302
organism: Danio rerio

uniprot Q7Q6D4 324
type: UnificationXref
id: Q7Q6D4
db: uniprot

uniprot Q3T0Y8 83
type: UnificationXref
id: Q3T0Y8
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 60

uniprot Q5I080 303
type: UnificationXref
id: Q5I080
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 47

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot H2Q3R5 42
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 308
organism: Mus musculus

uniprot P09471 245
type: UnificationXref
id: P09471
db: uniprot

TRANSCRIPTION_LEFT__preprodynorphin-RIGHT__preprodynorphin-_re11
type: TemplateReaction
product: preprodynorphin
xref: TRANSCRIPTION
participant: preprodynorphin
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

ncbitaxon 9606 49
type: UnificationXref
id: 9606
db: ncbitaxon

ncbitaxon 9913 15
type: UnificationXref
id: 9913
db: ncbitaxon

AGAP001506-PA
type: ProteinReference
xref: uniprot Q7PXP3 321
organism: Anopheles gambiae

ncbitaxon 9031 65
type: UnificationXref
id: 9031
db: ncbitaxon

PTHR24229:SF1
type: RelationshipXref
id: PTHR24229:SF1
db: PANTHER Family
relationship type: By Homology

cAMP
type: SmallMolecule
cellular location: cell
comment: SPECIES_TYPE=SIMPLE_MOLECULE

vasopressin
type: Protein
entity reference: vasopressin
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

G-protein
type: Protein
entity reference: G-protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa22 349
cellular location: cell
comment: SPECIES_TYPE=PROTEIN

uniprot Q6DGZ5 312
type: UnificationXref
id: Q6DGZ5
db: uniprot

KNOWN_TRANSITION_OMITTED_LEFT__prepropressophysin-RIGHT__provasopressin-_re9
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 366
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 367
left: prepropressophysin
interaction type: KNOWN_TRANSITION_OMITTED
right: provasopressin

dynorphin
type: Protein
entity reference: dynorphin
comment: SPECIES_TYPE=PROTEIN

PTHR10218:SF227
type: RelationshipXref
id: PTHR10218:SF227
db: PANTHER Family
relationship type: By Homology

Beta-neoendorphin-dynorphin
type: DnaReference
xref: PTHR11438:SF4
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 309
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot Q61017 310
organism: Mus musculus

Oxytocin-neurophysin 1
type: DnaReference
xref: PTHR11681:SF2
organism: Mus musculus

go GO:0005623 4
type: UnificationXref
id: GO:0005623
db: go

uniprot P63218 290
type: UnificationXref
id: P63218
db: uniprot

uniprot P18872 251
type: UnificationXref
id: P18872
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot Q9Z2P6 108
xref: PTHR19305:SF9
organism: Rattus norvegicus

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q9WUF4 107
organism: Rattus norvegicus

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q5R1X1 86
organism: Pan troglodytes

PTHR10218:SF230
type: RelationshipXref
id: PTHR10218:SF230
db: PANTHER Family
relationship type: By Homology

ncbitaxon 7668 54
type: UnificationXref
id: 7668
db: ncbitaxon

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 30

TRIGGER
type: RelationshipTypeVocabulary

uniprot P08753 243
type: UnificationXref
id: P08753
db: uniprot

uniprot P24787 131
type: UnificationXref
id: P24787
db: uniprot

uniprot P34975 116
type: UnificationXref
id: P34975
db: uniprot

uniprot F1LQT1 135
type: UnificationXref
id: F1LQT1
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot O14610 237
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re8 368
type: Stoichiometry
physical entity: prodynorphin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re8 369
type: Stoichiometry
physical entity: dynorphin
stoichiometric coefficient: 1.0

uniprot K7E376 236
type: UnificationXref
id: K7E376
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P49177 261
organism: Arabidopsis thaliana

uniprot F7G7I9 219
type: UnificationXref
id: F7G7I9
db: uniprot

uniprot Q6DH55 313
type: UnificationXref
id: Q6DH55
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 246
organism: Bos taurus

Kappa Receptor
type: Protein
entity reference: Kappa Receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s62 sa31 363
cellular location: cell
comment: SPECIES_TYPE=PROTEIN

uniprot Q9UBI6 337
type: UnificationXref
id: Q9UBI6
db: uniprot

uniprot Q9DC51 335
type: UnificationXref
id: Q9DC51
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T7 222
organism: Macaca mulatta

uniprot F6XWE8 200
type: UnificationXref
id: F6XWE8
db: uniprot

uniprot Q5XGD8 306
type: UnificationXref
id: Q5XGD8
db: uniprot

uniprot Q6DF43 311
type: UnificationXref
id: Q6DF43
db: uniprot

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 2

Vesicle associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot E2QUL2 21
organism: Canis lupus familiaris

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot F5HH30 186
organism: Neurospora crassa

Guanine nucleotide-binding protein G(O) subunit alpha isoform a
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot F7GQC5 221
organism: Macaca mulatta

uniprot P60878 64
type: UnificationXref
id: P60878
db: uniprot

uniprot Q5R1X1 86
type: UnificationXref
id: Q5R1X1
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P43425 260
organism: Rattus norvegicus

uniprot A0A2I3TUD1 150
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IGZ2 155
organism: Xenopus tropicalis

uniprot Q6P967 315
type: UnificationXref
id: Q6P967
db: uniprot

uniprot F7AXI7 122
type: UnificationXref
id: F7AXI7
db: uniprot

TRANSPORT_LEFT__vasopressin-RIGHT__vasopressin-_re1
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 387
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 386
left: vasopressin
interaction type: TRANSPORT
right: vasopressin

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q28024 296
organism: Bos taurus

uniprot Q28HP6 81
type: UnificationXref
id: Q28HP6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XWE8 200
organism: Monodelphis domestica

uniprot P50146 262
type: UnificationXref
id: P50146
db: uniprot

uniprot A9JTC8 160
type: UnificationXref
id: A9JTC8
db: uniprot

uniprot Q6TH03 319
type: UnificationXref
id: Q6TH03
db: uniprot

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot Q92356 96
organism: Schizosaccharomyces pombe

Oxytocin-neurophysin 1
type: DnaReference
xref: PTHR11681:SF2
organism: Homo sapiens

AGAP005904-PA
type: ProteinReference
xref: PTHR10218:SF310
xref: uniprot Q7Q6E0 325
organism: Anopheles gambiae

uniprot Q80SZ7 329
type: UnificationXref
id: Q80SZ7
db: uniprot

AGAP005911-PA
type: ProteinReference
xref: uniprot Q7Q6D4 324
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F6UJE8 193
organism: Monodelphis domestica

AGAP005913-PA
type: ProteinReference
xref: uniprot Q7Q6D2 322
organism: Anopheles gambiae

AGAP005912-PA
type: ProteinReference
xref: uniprot Q7Q6D3 323
organism: Anopheles gambiae

dynorphin
type: Protein
entity reference: dynorphin
feature: COMPLEX PARTICIPANT BINDING FEATURE s60 sa26 357
cellular location: cell
comment: SPECIES_TYPE=PROTEIN

Bos taurus
type: BioSource
xref: ncbitaxon 9913 15

dehydration or salt loading stress
type: PhysicalEntity
cellular location: magnocellular cells in hypothalamus c4
comment: SPECIES_TYPE=UNKNOWN

uniprot G3V6P8 223
type: UnificationXref
id: G3V6P8
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 34

prepropressophysin
type: DnaRegion
entity reference: prepropressophysin
cellular location: nucleus
comment: SPECIES_TYPE=GENE

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q3W7 228
organism: Pan troglodytes

uniprot F6V001 137
type: UnificationXref
id: F6V001
db: uniprot

uniprot P63027 72
type: UnificationXref
id: P63027
db: uniprot

uniprot P43425 260
type: UnificationXref
id: P43425
db: uniprot

ncbitaxon 6238 20
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot Q9W3J1 339
type: UnificationXref
id: Q9W3J1
db: uniprot

uniprot E1BW98 168
type: UnificationXref
id: E1BW98
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q28H40 297
organism: Xenopus tropicalis

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P30671 256
organism: Bos taurus

G protein alpha i subunit
type: ProteinReference
xref: PTHR10218:SF310
xref: uniprot P20353 252
organism: Drosophila melanogaster

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 163

prodynorphin
type: Protein
entity reference: prodynorphin
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot F7A472 204
type: UnificationXref
id: F7A472
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot F1A421 179
organism: Dictyostelium purpureum

uniprot F8W5D0 123
type: UnificationXref
id: F8W5D0
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 22

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NGS8 151
organism: Bos taurus

uniprot B2RSH2 161
type: UnificationXref
id: B2RSH2
db: uniprot

uniprot Q6PC54 92
type: UnificationXref
id: Q6PC54
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 231
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7G7I9 219
organism: Ornithorhynchus anatinus

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot Q80TL1 146
xref: PTHR45627:SF6
organism: Mus musculus

VAMP3 isoform 1
type: ProteinReference
xref: uniprot G2HIJ9 40
xref: PTHR45701:SF6
organism: Pan troglodytes

uniprot X1WDQ5 341
type: UnificationXref
id: X1WDQ5
db: uniprot

PTHR45701:SF10
type: RelationshipXref
id: PTHR45701:SF10
db: PANTHER Family
relationship type: By Homology

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot E2R907 23
xref: PTHR19305:SF5
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7CFG8 207
organism: Monodelphis domestica

ncbitaxon 8364 30
type: UnificationXref
id: 8364
db: ncbitaxon

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 65

Beta-neoendorphin-dynorphin
type: ProteinReference
xref: PTHR11438:SF4
xref: uniprot F6R267 111
organism: Macaca mulatta

Kappa Receptor s62 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Kappa Receptor
stoichiometric coefficient: 1.0

uniprot F6VPY1 196
type: UnificationXref
id: F6VPY1
db: uniprot

OXT isoform 1
type: ProteinReference
xref: uniprot H2QJV1 124
organism: Pan troglodytes

KNOWN_TRANSITION_OMITTED_LEFT__preprodynorphin-RIGHT__prodynorphin-_re2
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 384
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 385
left: preprodynorphin
interaction type: KNOWN_TRANSITION_OMITTED
right: prodynorphin

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot P51828 142
organism: Homo sapiens

uniprot P83351 75
type: UnificationXref
id: P83351
db: uniprot

AVP isoform 1
type: ProteinReference
xref: uniprot H2QJV2 125
xref: PTHR11681:SF9
organism: Pan troglodytes

ncbitaxon 665079 158
type: UnificationXref
id: 665079
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7GI54 220
organism: Monodelphis domestica

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot P51829 143
organism: Mus musculus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: analgesic pain relief
controller: cAMP

SNAP25 homologous protein SNAP33
type: ProteinReference
xref: uniprot Q9S7P9 103
organism: Arabidopsis thaliana

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot Q9VH76 105
organism: Drosophila melanogaster

Gnb3 protein
type: ProteinReference
xref: uniprot Q6P025 314
organism: Danio rerio

uniprot P17343 249
type: UnificationXref
id: P17343
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5KI86 304
organism: Cryptococcus neoformans

Guanine nucleotide binding protein, beta subunit
type: ProteinReference
xref: uniprot E9FUX0 176
organism: Daphnia pulex

PARTICIPANT STOICHIOMETRY re7 370
type: Stoichiometry
physical entity: dynorphin
stoichiometric coefficient: 1.0

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa21 347
cellular location: cell
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re7 371
type: Stoichiometry
physical entity: dynorphin
stoichiometric coefficient: 1.0

ACTIVE 147
type: EntityFeature
comment: Active state

eco ECO:0000250 8
type: UnificationXref
id: ECO:0000250
db: eco

preprodynorphin
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=untitled.RNA.RNA.preprodynorphin
comment: ENTITY_REFERENCE_NOTES=Long Name: preprodynorphinSynonym: Synonym not specifiedAccession: G06049

Guanine nucleotide-binding protein (G protein), alpha-activating activity polypeptide O, b
type: ProteinReference
xref: PTHR10218:SF331
xref: uniprot Q6P967 315
organism: Danio rerio

dynorphin s60 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: dynorphin
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9UBI6 337
organism: Homo sapiens

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__preprodynorphin-RIGHT__preprodynorphin-_re11
control type: ACTIVATION
controller: dehydration or salt loading stress

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot Q29450 145
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 189
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 201
organism: Monodelphis domestica

THO complex subunit, putative
type: ProteinReference
xref: uniprot B7Q3T6 162
organism: Ixodes scapularis

uniprot P54313 270
type: UnificationXref
id: P54313
db: uniprot

uniprot P63044 73
type: UnificationXref
id: P63044
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XHP0 199
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9DAS9 334
organism: Mus musculus

uniprot Q10282 293
type: UnificationXref
id: Q10282
db: uniprot

uniprot Q2KJD2 82
type: UnificationXref
id: Q2KJD2
db: uniprot

Oxytocin
type: DnaReference
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ASR8 205
organism: Macaca mulatta

Arginine vasopressin (Fragment)
type: DnaReference
organism: Danio rerio

PARTICIPANT STOICHIOMETRY re2 384
type: Stoichiometry
physical entity: preprodynorphin
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P26308 253
organism: Drosophila melanogaster

TRANSCRIPTION_LEFT__prepropressophysin-RIGHT__prepropressophysin-_re12
type: TemplateReaction
product: prepropressophysin
xref: TRANSCRIPTION
participant: prepropressophysin
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa23 351
cellular location: cell
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F1NLV4 182
type: UnificationXref
id: F1NLV4
db: uniprot

PARTICIPANT STOICHIOMETRY re2 385
type: Stoichiometry
physical entity: prodynorphin
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CXD0 209
organism: Monodelphis domestica

G-protein beta subunit
type: ProteinReference
xref: uniprot Q5BH99 301
organism: Emericella nidulans

uniprot Q9ERB0 99
type: UnificationXref
id: Q9ERB0
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot F6VM87 32
organism: Monodelphis domestica

G-protein
type: Protein
entity reference: G-protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa24 353
cellular location: cell
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re6 372
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re6 373
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ Sigma Receptor/endorphins (morphine like))
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re6 376
type: Stoichiometry
physical entity: Complex (Sigma Receptor/endorphins (morphine like))
stoichiometric coefficient: 1.0

ncbitaxon 7227 47
type: UnificationXref
id: 7227
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re6 374
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Vasopressin-neurophysin 2-copeptin
type: ProteinReference
xref: uniprot A0A3Q1LXY0 119
xref: PTHR11681:SF9
organism: Bos taurus

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 26

PARTICIPANT STOICHIOMETRY re6 375
type: Stoichiometry
physical entity: Complex (GTP/G-protein)
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 181
organism: Bos taurus

ncbitaxon 367110 187
type: UnificationXref
id: 367110
db: ncbitaxon

vasopressin
type: Protein
entity reference: vasopressin
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re9 366
type: Stoichiometry
physical entity: prepropressophysin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re9 367
type: Stoichiometry
physical entity: provasopressin
stoichiometric coefficient: 1.0

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot P26769 141
organism: Rattus norvegicus

Synaptosomal-associated protein 23
type: ProteinReference
xref: uniprot O09044 51
xref: PTHR19305:SF4
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7BB02 206
organism: Macaca mulatta

provasopressin
type: ProteinReference
xref: P05999
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: provasopressinSynonym: Synonym not specifiedAccession: P05999
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.provasopressin
member entity reference: Vasopressin-neurophysin 2-copeptin
member entity reference: Oxytocin-neurophysin 1
member entity reference: Arginine vasopressin (Fragment)
member entity reference: Vasotocin-neurophysin VT
member entity reference: OXT isoform 1
member entity reference: Arginine vasopressin
member entity reference: Uncharacterized protein
member entity reference: AVP isoform 1
member entity reference: Oxytocin

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 328
organism: Danio rerio

uniprot E2R907 23
type: UnificationXref
id: E2R907
db: uniprot

ncbitaxon 559292 60
type: UnificationXref
id: 559292
db: ncbitaxon

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A8X8S6 19
xref: PTHR19305:SF14
organism: Caenorhabditis briggsae

uniprot Q3SZ98 299
type: UnificationXref
id: Q3SZ98
db: uniprot

uniprot Q3KRE3 298
type: UnificationXref
id: Q3KRE3
db: uniprot

uniprot K7ADQ0 140
type: UnificationXref
id: K7ADQ0
db: uniprot

uniprot O44419 53
type: UnificationXref
id: O44419
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q63666 90
organism: Rattus norvegicus

uniprot P62871 273
type: UnificationXref
id: P62871
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot Q7SZZ5 94
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3KRE3 298
organism: Rattus norvegicus

uniprot F6VM87 32
type: UnificationXref
id: F6VM87
db: uniprot

uniprot E9FUX0 176
type: UnificationXref
id: E9FUX0
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot E2RHY4 174
organism: Canis lupus familiaris

uniprot F7FD32 215
type: UnificationXref
id: F7FD32
db: uniprot

uniprot Q9DAS9 334
type: UnificationXref
id: Q9DAS9
db: uniprot

uniprot F6YZA3 202
type: UnificationXref
id: F6YZA3
db: uniprot

uniprot H2Q9G5 229
type: UnificationXref
id: H2Q9G5
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot O60262 239
organism: Homo sapiens

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot Q3ZCA7 300
organism: Bos taurus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot D3ZLD6 167
organism: Rattus norvegicus

uniprot F6W548 197
type: UnificationXref
id: F6W548
db: uniprot

ncbitaxon 9258 34
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot F7F580 214
type: UnificationXref
id: F7F580
db: uniprot

uniprot P36975 62
type: UnificationXref
id: P36975
db: uniprot

uniprot P26308 253
type: UnificationXref
id: P26308
db: uniprot

PTHR19305:SF5
type: RelationshipXref
id: PTHR19305:SF5
db: PANTHER Family
relationship type: By Homology

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 97

uniprot Q803H5 328
type: UnificationXref
id: Q803H5
db: uniprot

PTHR19305:SF9
type: RelationshipXref
id: PTHR19305:SF9
db: PANTHER Family
relationship type: By Homology

uniprot P18851 250
type: UnificationXref
id: P18851
db: uniprot

GO GO:0005783 2
type: UnificationXref
id: GO:0005783
db: GO

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: antidiuretic effects
controller: vasopressin

ncbitaxon 6239 17
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot Q6P025 314
type: UnificationXref
id: Q6P025
db: uniprot

PTHR19305:SF4
type: RelationshipXref
id: PTHR19305:SF4
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

dynorphin s59 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: dynorphin
stoichiometric coefficient: 1.0

uniprot A0A1D5RHE7 134
type: UnificationXref
id: A0A1D5RHE7
db: uniprot

GO GO:0070382 5
type: UnificationXref
id: GO:0070382
db: GO

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q0VFC4 292
organism: Xenopus tropicalis

uniprot F7ERP8 212
type: UnificationXref
id: F7ERP8
db: uniprot

ncbitaxon 214684 305
type: UnificationXref
id: 214684
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6TH03 319
organism: Danio rerio

uniprot P60877 63
type: UnificationXref
id: P60877
db: uniprot

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot Q20636 295
organism: Caenorhabditis elegans

uniprot F5HMS4 25
type: UnificationXref
id: F5HMS4
db: uniprot

GNB4 protein
type: ProteinReference
xref: uniprot A5PKD6 156
organism: Bos taurus

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 49

Complex (GDP/G-protein/ Sigma Receptor)
type: Complex
component stoichiometry: G protein s21 sa30 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s19 sa29 STOICHIOMETRY ID COMPLEX
component stoichiometry: Kappa Receptor s62 sa31 STOICHIOMETRY ID COMPLEX
component: Kappa Receptor
component: GDP
component: G-protein
feature: COMPLEX BINDING FEATURE s31 csa4 362
feature: COMPLEX BINDING FEATURE s31 csa4 360
feature: COMPLEX BINDING FEATURE s31 csa4 358
cellular location: cell

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot F7FD32 215
organism: Macaca mulatta

uniprot Q8WSS1 330
type: UnificationXref
id: Q8WSS1
db: uniprot

uniprot F6VL43 195
type: UnificationXref
id: F6VL43
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q28HP6 81
organism: Xenopus tropicalis

uniprot P01186 130
type: UnificationXref
id: P01186
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot Q7ZW82 327
organism: Danio rerio

uniprot A0NEH6 152
type: UnificationXref
id: A0NEH6
db: uniprot

uniprot H2PZA6 225
type: UnificationXref
id: H2PZA6
db: uniprot

ncbitaxon 284812 97
type: UnificationXref
id: 284812
db: ncbitaxon

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 54

uniprot E9H7Z0 178
type: UnificationXref
id: E9H7Z0
db: uniprot

AC
type: ProteinReference
xref: P06001
standard name: adenylate cyclase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.AC
comment: ENTITY_REFERENCE_NOTES=Long Name: adenylate cyclaseSynonym: Long Name: AC,adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclaseAccession: P06001
member entity reference: Adenylate cyclase
member entity reference: Adenylate cyclase type 2
member entity reference: Adenylate cyclase type 7

Proenkephalin-B
type: ProteinReference
xref: PTHR11438:SF4
xref: uniprot O35417 112
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E1C795 169
organism: Gallus gallus

uniprot F1QC27 121
type: UnificationXref
id: F1QC27
db: uniprot

uniprot F6ZAV4 138
type: UnificationXref
id: F6ZAV4
db: uniprot

uniprot F7CFG8 207
type: UnificationXref
id: F7CFG8
db: uniprot

uniprot F5HH30 186
type: UnificationXref
id: F5HH30
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot R4GKD1 340
organism: Gallus gallus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 213
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NLV4 182
organism: Gallus gallus

uniprot F7H6T7 222
type: UnificationXref
id: F7H6T7
db: uniprot

uniprot E2RHY4 174
type: UnificationXref
id: E2RHY4
db: uniprot

GDP
type: SmallMolecule
cellular location: cell
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot P31109 59
organism: Saccharomyces cerevisiae

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V8K2 224
organism: Rattus norvegicus

uniprot P50150 263
type: UnificationXref
id: P50150
db: uniprot

uniprot F6VUT7 33
type: UnificationXref
id: F6VUT7
db: uniprot

uniprot F1PZS7 120
type: UnificationXref
id: F1PZS7
db: uniprot

PTHR10218:SF73
type: RelationshipXref
id: PTHR10218:SF73
db: PANTHER Family
relationship type: By Homology

By Homology
type: RelationshipTypeVocabulary

uniprot E2R2S3 170
type: UnificationXref
id: E2R2S3
db: uniprot

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot A7EDU2 157
organism: Sclerotinia sclerotiorum

TRANSCRIPTION
type: RelationshipTypeVocabulary

uniprot Q6PBR4 316
type: UnificationXref
id: Q6PBR4
db: uniprot

uniprot Q7ZW82 327
type: UnificationXref
id: Q7ZW82
db: uniprot

uniprot Q9S7P9 103
type: UnificationXref
id: Q9S7P9
db: uniprot

SNAP29 isoform 1
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot H2QLA1 44
organism: Pan troglodytes

uniprot F7E427 210
type: UnificationXref
id: F7E427
db: uniprot

G protein subunit alpha i3
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot Q5I080 303
organism: Xenopus tropicalis

PTHR45627:SF9
type: RelationshipXref
id: PTHR45627:SF9
db: PANTHER Family
relationship type: By Homology

uniprot F1A421 179
type: UnificationXref
id: F1A421
db: uniprot

PTHR45627:SF6
type: RelationshipXref
id: PTHR45627:SF6
db: PANTHER Family
relationship type: By Homology

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 258

uniprot A0A2J8MS47 110
type: UnificationXref
id: A0A2J8MS47
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F2Z3T8 185
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot G2HIJ9 40
type: UnificationXref
id: G2HIJ9
db: uniprot

preprodynorphin
type: DnaRegionReference
member entity reference: Beta-neoendorphin-dynorphin
member entity reference: Proenkephalin-B
member entity reference: PDYN isoform 1
xref: G06047
comment: ENTITY_REFERENCE_NOTES=Long Name: preprodynorphinSynonym: Synonym not specifiedAccession: G06047
comment: ENTITY_REFERENCE_ID_DESC=untitled.GENE.GENE.preprodynorphin

uniprot F6R267 111
type: UnificationXref
id: F6R267
db: uniprot

uniprot P63216 288
type: UnificationXref
id: P63216
db: uniprot

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 18

uniprot F7ASR8 205
type: UnificationXref
id: F7ASR8
db: uniprot

Complex (Sigma Receptor/endorphins (morphine like))
type: Complex
component stoichiometry: Kappa Receptor s63 sa27 STOICHIOMETRY ID COMPLEX
component stoichiometry: dynorphin s59 sa28 STOICHIOMETRY ID COMPLEX
component: Kappa Receptor
component: dynorphin
feature: COMPLEX BINDING FEATURE s54 csa3 344
feature: COMPLEX BINDING FEATURE s54 csa3 342
cellular location: cell

dynorphin
type: Protein
entity reference: dynorphin
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

Kappa-type opioid receptor
type: ProteinReference
xref: PTHR24229:SF1
xref: uniprot Q2KIP6 118
organism: Bos taurus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7E376 236
organism: Monodelphis domestica

prodynorphin
type: ProteinReference
xref: P05997
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.prodynorphin
comment: ENTITY_REFERENCE_NOTES=Long Name: prodynorphinSynonym: Synonym not specifiedAccession: P05997
member entity reference: Beta-neoendorphin-dynorphin
member entity reference: Proenkephalin-B
member entity reference: PDYN isoform 1

uniprot E2RGI5 173
type: UnificationXref
id: E2RGI5
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 329
organism: Mus musculus

uniprot P59768 272
type: UnificationXref
id: P59768
db: uniprot

uniprot Q9LMG8 100
type: UnificationXref
id: Q9LMG8
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q90Z40 332
organism: Danio rerio

ncbitaxon 10116 70
type: UnificationXref
id: 10116
db: ncbitaxon

GTP s6 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Opioid receptor kappa 1
type: ProteinReference
xref: PTHR24229:SF1
xref: uniprot J9P639 114
organism: Canis lupus familiaris

uniprot P16378 247
type: UnificationXref
id: P16378
db: uniprot

uniprot F7EPG4 39
type: UnificationXref
id: F7EPG4
db: uniprot

uniprot Q80TL1 146
type: UnificationXref
id: Q80TL1
db: uniprot

uniprot P31109 59
type: UnificationXref
id: P31109
db: uniprot

uniprot G3V8K2 224
type: UnificationXref
id: G3V8K2
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 203
organism: Macaca mulatta

uniprot F6XYX9 35
type: UnificationXref
id: F6XYX9
db: uniprot

t-SNARE protein aex-4
type: ProteinReference
xref: uniprot G5EEN8 41
organism: Caenorhabditis elegans

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__vasopressin-RIGHT__vasopressin-_re1
control type: ACTIVATION
controller: SNARE COMPLEX

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

Kappa-type opioid receptor
type: ProteinReference
xref: PTHR24229:SF1
xref: uniprot P41145 117
organism: Homo sapiens

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot P23763 58
xref: PTHR45701:SF1
organism: Homo sapiens

G protein subunit beta 3
type: ProteinReference
xref: uniprot H2R3A6 233
organism: Pan troglodytes

uniprot Q9CXP8 333
type: UnificationXref
id: Q9CXP8
db: uniprot

uniprot P63078 281
type: UnificationXref
id: P63078
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot F6ZAV4 138
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F7A472 204
organism: Xenopus tropicalis

uniprot F6Z5I2 37
type: UnificationXref
id: F6Z5I2
db: uniprot

uniprot P38400 259
type: UnificationXref
id: P38400
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

Kappa-type opioid receptor
type: ProteinReference
xref: PTHR24229:SF1
xref: uniprot P34975 116
organism: Rattus norvegicus

uniprot P51828 142
type: UnificationXref
id: P51828
db: uniprot

uniprot P01178 127
type: UnificationXref
id: P01178
db: uniprot

uniprot H2RCB8 45
type: UnificationXref
id: H2RCB8
db: uniprot

uniprot A1L271 153
type: UnificationXref
id: A1L271
db: uniprot

Complex (GDP/G-protein/ Sigma Receptor/endorphins (morphine like))
type: Complex
component stoichiometry: G protein s33 sa24 STOICHIOMETRY ID COMPLEX
component stoichiometry: Kappa Receptor s64 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s30 sa23 STOICHIOMETRY ID COMPLEX
component stoichiometry: dynorphin s60 sa26 STOICHIOMETRY ID COMPLEX
component: dynorphin
component: G-protein
component: GDP
component: Kappa Receptor
feature: COMPLEX BINDING FEATURE s57 csa2 354
feature: COMPLEX BINDING FEATURE s57 csa2 350
feature: COMPLEX BINDING FEATURE s57 csa2 352
feature: COMPLEX BINDING FEATURE s57 csa2 356
cellular location: cell

uniprot P60879 66
type: UnificationXref
id: P60879
db: uniprot

uniprot F6UBJ8 29
type: UnificationXref
id: F6UBJ8
db: uniprot

Kappa Receptor
type: Protein
entity reference: Kappa Receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s63 sa27 343
cellular location: cell
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 13616 28
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot P63077 280
type: UnificationXref
id: P63077
db: uniprot

KNOWN_TRANSITION_OMITTED
type: InteractionVocabulary

uniprot P04897 240
type: UnificationXref
id: P04897
db: uniprot

uniprot Q9N0Y0 102
type: UnificationXref
id: Q9N0Y0
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: uniprot F7DL70 139
xref: PTHR45627:SF9
organism: Macaca mulatta

P06002
type: UnificationXref
id: P06002
db: PANTHER Pathway Component

P06003
type: UnificationXref
id: P06003
db: PANTHER Pathway Component

KNOWN_TRANSITION_OMITTED_LEFT__provasopressin-RIGHT__vasopressin-_re10
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 364
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 365
left: provasopressin
interaction type: KNOWN_TRANSITION_OMITTED
right: vasopressin

GDP s19 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot Q7ZUC1 95
type: UnificationXref
id: Q7ZUC1
db: uniprot

P06000
type: UnificationXref
id: P06000
db: PANTHER Pathway Component

P06001
type: UnificationXref
id: P06001
db: PANTHER Pathway Component

GO GO:0005634 3
type: UnificationXref
id: GO:0005634
db: GO

uniprot Q6PBY0 317
type: UnificationXref
id: Q6PBY0
db: uniprot

untitled
type: Pathway
pathway component: DISSOCIATION_LEFT__GTP-_Complex__GDP_G_protein__Sigma_Receptor_endorphins__morphine_like__-RIGHT__GDP-_Complex__GTP_G_protein_-_Complex__Sigma_Receptor_endorphins__morphine_like__-_re6
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__prodynorphin-RIGHT__dynorphin-_re8
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__provasopressin-RIGHT__vasopressin-_re10
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__preprodynorphin-RIGHT__prodynorphin-_re2
pathway component: PHYSICAL_STIMULATION
pathway component: TRANSCRIPTION_LEFT__prepropressophysin-RIGHT__prepropressophysin-_re12
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__prepropressophysin-RIGHT__provasopressin-_re9
pathway component: HETERODIMER_ASSOCIATION_LEFT__dynorphin-_Complex__GDP_G_protein__Sigma_Receptor_-RIGHT__Complex__GDP_G_protein__Sigma_Receptor_endorphins__morphine_like__-_re5
pathway component: TRANSPORT_LEFT__vasopressin-RIGHT__vasopressin-_re1
pathway component: TRANSPORT_LEFT__dynorphin-RIGHT__dynorphin-_re7
pathway component: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re4
pathway component: TRANSCRIPTION_LEFT__preprodynorphin-RIGHT__preprodynorphin-_re11
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re3
xref: PANTHER Pathway P05916 1
comment: MODEL_NOTES=

uniprot F6RIM7 190
type: UnificationXref
id: F6RIM7
db: uniprot

PARTICIPANT STOICHIOMETRY re5 377
type: Stoichiometry
physical entity: dynorphin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 378
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ Sigma Receptor)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 379
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ Sigma Receptor/endorphins (morphine like))
stoichiometric coefficient: 1.0

Arginine vasopressin
type: DnaReference
xref: PTHR11681:SF9
organism: Canis lupus familiaris

uniprot Q5ASG1 84
type: UnificationXref
id: Q5ASG1
db: uniprot

uniprot P08752 242
type: UnificationXref
id: P08752
db: uniprot

uniprot Q28024 296
type: UnificationXref
id: Q28024
db: uniprot

Syntaxin 3A
type: ProteinReference
xref: uniprot Q6PHV0 93
xref: PTHR19957:SF34
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ERP8 212
organism: Ornithorhynchus anatinus

Syntaxin 3
type: ProteinReference
xref: uniprot F7EPG4 39
xref: PTHR19957:SF34
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6VPY1 196
organism: Ornithorhynchus anatinus

uniprot A0A2I3S4R3 148
type: UnificationXref
id: A0A2I3S4R3
db: uniprot

uniprot Q61016 309
type: UnificationXref
id: Q61016
db: uniprot

uniprot O00161 48
type: UnificationXref
id: O00161
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P36408 257
organism: Dictyostelium discoideum

uniprot P63045 74
type: UnificationXref
id: P63045
db: uniprot

uniprot Q7T3D3 326
type: UnificationXref
id: Q7T3D3
db: uniprot

uniprot Q15836 79
type: UnificationXref
id: Q15836
db: uniprot