uniprot F6W548 79
type: UnificationXref
id: F6W548
db: uniprot

uniprot F6XHP0 81
type: UnificationXref
id: F6XHP0
db: uniprot

Neuronal synaptobrevin, isoform J
type: ProteinReference
xref: PTHR45701:SF3
xref: uniprot M9PE71 259
organism: Drosophila melanogaster

uniprot Q9VH76 308
type: UnificationXref
id: Q9VH76
db: uniprot

G protein subunit alpha i3
type: ProteinReference
xref: uniprot H2PZK9 108
xref: PTHR10218:SF230
organism: Pan troglodytes

uniprot Q3KRE3 185
type: UnificationXref
id: Q3KRE3
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q5ZJ03 195
organism: Gallus gallus

ncbitaxon 559292 135
type: UnificationXref
id: 559292
db: ncbitaxon

PTHR10218:SF331
type: RelationshipXref
id: PTHR10218:SF331
db: PANTHER Family
relationship type: By Homology

Syntaxin-3
type: ProteinReference
xref: uniprot Q64704 296
xref: PTHR19957:SF34
organism: Mus musculus

uniprot O00161 260
type: UnificationXref
id: O00161
db: uniprot

uniprot F1MJV4 325
type: UnificationXref
id: F1MJV4
db: uniprot

G protein subunit alpha i1
type: ProteinReference
xref: uniprot F1P977 64
xref: PTHR10218:SF227
organism: Canis lupus familiaris

uniprot F6SED9 243
type: UnificationXref
id: F6SED9
db: uniprot

uniprot P50146 148
type: UnificationXref
id: P50146
db: uniprot

uniprot F6ZIZ9 85
type: UnificationXref
id: F6ZIZ9
db: uniprot

uniprot P63026 278
type: UnificationXref
id: P63026
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IFL6 33
organism: Bos taurus

uniprot F6VPY1 78
type: UnificationXref
id: F6VPY1
db: uniprot

uniprot P60877 272
type: UnificationXref
id: P60877
db: uniprot

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot Q08462 333
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63212 170
organism: Bos taurus

uniprot O14610 119
type: UnificationXref
id: O14610
db: uniprot

uniprot A0A3Q1LYB4 234
type: UnificationXref
id: A0A3Q1LYB4
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 16

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XYX9 248
xref: PTHR45701:SF6
organism: Monodelphis domestica

Complex (GTP/G-protein)
type: Complex
component stoichiometry: G protein s8 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s6 sa1 STOICHIOMETRY ID COMPLEX
component: GTP
component: G-protein
feature: COMPLEX BINDING FEATURE s7 a11 336
feature: COMPLEX BINDING FEATURE s7 a11 338
feature: ACTIVE 312
cellular location: cytosol

uniprot F6YMH2 249
type: UnificationXref
id: F6YMH2
db: uniprot

uniprot P20353 137
type: UnificationXref
id: P20353
db: uniprot

uniprot P63045 281
type: UnificationXref
id: P63045
db: uniprot

uniprot E2RGI5 54
type: UnificationXref
id: E2RGI5
db: uniprot

Delta-type opioid receptor
type: ProteinReference
xref: uniprot P33533 319
xref: PTHR24229:SF2
organism: Rattus norvegicus

uniprot P59768 158
type: UnificationXref
id: P59768
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 163
organism: Homo sapiens

PTHR19305:SF14
type: RelationshipXref
id: PTHR19305:SF14
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 162
organism: Mus musculus

uniprot F7F580 96
type: UnificationXref
id: F7F580
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 160
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 161
organism: Homo sapiens

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot P62881 165
organism: Mus musculus

PTHR10218:SF310
type: RelationshipXref
id: PTHR10218:SF310
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 164
organism: Mus musculus

uniprot Q9N0Y0 305
type: UnificationXref
id: Q9N0Y0
db: uniprot

ACTH
type: Protein
entity reference: ACTH
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

Mu or Delta receptor
type: Protein
entity reference: Mu or Delta receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s48 sa8 349
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Anaelgesia
controller: cAMP

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot F6UFJ7 245
organism: Macaca mulatta

uniprot Q15KE4 181
type: UnificationXref
id: Q15KE4
db: uniprot

STATE_TRANSITION_LEFT__K_PLUS__channel-RIGHT__K_PLUS__channel-_re11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 359
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 358
left: K+ channel
interaction type: STATE_TRANSITION
right: K+ channel

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 68

Gnai3 protein
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot A9JTC8 39
organism: Danio rerio

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot F6WNJ9 80
organism: Xenopus tropicalis

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 159
organism: Bos taurus

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot F1LQT1 324
organism: Rattus norvegicus

uniprot E9H7Z0 59
type: UnificationXref
id: E9H7Z0
db: uniprot

uniprot P26308 138
type: UnificationXref
id: P26308
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot F7CTP1 90
organism: Macaca mulatta

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60879 274
xref: PTHR19305:SF5
organism: Mus musculus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60878 273
xref: PTHR19305:SF5
organism: Gallus gallus

uniprot F6Z5I2 250
type: UnificationXref
id: F6Z5I2
db: uniprot

uniprot Q9CXP8 221
type: UnificationXref
id: Q9CXP8
db: uniprot

Putative synaptobrevin homologue SNC1/2 (Eurofung)
type: ProteinReference
xref: uniprot Q5ASG1 291
organism: Emericella nidulans

Guanine nucleotide binding protein, beta 3
type: ProteinReference
xref: uniprot Q5XGD8 194
organism: Xenopus tropicalis

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60877 272
xref: PTHR19305:SF5
organism: Macaca mulatta

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 6

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60880 275
organism: Homo sapiens

Guanine nucleotide-binding protein G(O) subunit alpha 1
type: ProteinReference
xref: uniprot E9H7Z0 59
xref: PTHR10218:SF302
organism: Daphnia pulex

cAMP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7G7I9 101
type: UnificationXref
id: F7G7I9
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q2KJD2 289
organism: Bos taurus

uniprot F1NLV4 63
type: UnificationXref
id: F1NLV4
db: uniprot

uniprot F6VUT7 247
type: UnificationXref
id: F6VUT7
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63044 280
organism: Mus musculus

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63045 281
organism: Rattus norvegicus

uniprot Q61017 198
type: UnificationXref
id: Q61017
db: uniprot

ncbitaxon 6945 42
type: UnificationXref
id: 6945
db: ncbitaxon

Synaptobrevin-1
type: ProteinReference
xref: uniprot O02495 261
xref: PTHR45701:SF3
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein subunit beta-5a
type: ProteinReference
xref: uniprot A1L271 32
organism: Danio rerio

uniprot Q9HAV0 224
type: UnificationXref
id: Q9HAV0
db: uniprot

uniprot P63214 172
type: UnificationXref
id: P63214
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZSF0 45
organism: Branchiostoma floridae

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
type: ProteinReference
xref: uniprot Q6TNT8 208
xref: PTHR10218:SF73
organism: Danio rerio

uniprot P63024 276
type: UnificationXref
id: P63024
db: uniprot

uniprot Q90Z40 220
type: UnificationXref
id: Q90Z40
db: uniprot

GO GO:0005794 4
type: UnificationXref
id: GO:0005794
db: GO

Complex (Mu or Kappa/beta-Endorphin)
type: Complex
component stoichiometry: Mu or Delta receptor s49 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: beta Endorphin s23 sa11 STOICHIOMETRY ID COMPLEX
component: Mu or Delta receptor
component: beta-Endorphin
feature: COMPLEX BINDING FEATURE s27 a33 340
feature: COMPLEX BINDING FEATURE s27 a33 342
cellular location: cytosol

Vesicle-associated membrane protein 8 (Endobrevin)
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q7ZUC1 300
organism: Danio rerio

uniprot Q7PXP3 209
type: UnificationXref
id: Q7PXP3
db: uniprot

uniprot O70404 265
type: UnificationXref
id: O70404
db: uniprot

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa6 345
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 7165 31
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot Q6DH55 201
type: UnificationXref
id: Q6DH55
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__K_PLUS__channel-RIGHT__K_PLUS__channel-_re11
controller: Complex (GTP/G-protein)

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63027 279
organism: Homo sapiens

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63026 278
organism: Bos taurus

ncbitaxon 9544 10
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot F6XWE8 82
type: UnificationXref
id: F6XWE8
db: uniprot

uniprot F7ERP8 94
type: UnificationXref
id: F7ERP8
db: uniprot

uniprot P33328 270
type: UnificationXref
id: P33328
db: uniprot

uniprot F6UFJ7 245
type: UnificationXref
id: F6UFJ7
db: uniprot

uniprot F7EPG4 252
type: UnificationXref
id: F7EPG4
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63024 276
organism: Mus musculus

G-protein
type: Protein
entity reference: G-protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa4 355
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Vesicle-associated membrane protein 3
type: ProteinReference
xref: uniprot P63025 277
xref: PTHR45701:SF6
organism: Rattus norvegicus

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 69
organism: Ornithorhynchus anatinus

Proopiomelanocortin
type: ProteinReference
xref: PTHR11416:SF7
xref: uniprot Q95J84 21
organism: Monodelphis domestica

uniprot F1P977 64
type: UnificationXref
id: F1P977
db: uniprot

uniprot Q9S7P9 306
type: UnificationXref
id: Q9S7P9
db: uniprot

uniprot H2Q995 256
type: UnificationXref
id: H2Q995
db: uniprot

G protein s14 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-protein
stoichiometric coefficient: 1.0

ncbitaxon 214684 193
type: UnificationXref
id: 214684
db: ncbitaxon

Mu or Delta receptor s49 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Mu or Delta receptor
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R9G5 53
organism: Canis lupus familiaris

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot O70404 265
organism: Mus musculus

uniprot F7CTP1 90
type: UnificationXref
id: F7CTP1
db: uniprot

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot O14775 120
organism: Homo sapiens

VAMP2 isoform 3
type: ProteinReference
xref: uniprot H2RCB8 258
xref: PTHR45701:SF5
organism: Pan troglodytes

Vesicle associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot F6Z5I2 250
organism: Monodelphis domestica

uniprot P62874 162
type: UnificationXref
id: P62874
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RIM7 72
xref: PTHR10218:SF230
organism: Monodelphis domestica

neurons of nucleus tractus solitarius also in anterior pituitary, neocortex, basal ganglia, amygldala c5
type: CellularLocationVocabulary
comment: neurons of nucleus tractus solitarius (also in anterior pituitary, neocortex, basal ganglia, amygldala)

GDP s13 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 52
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R2S3 50
organism: Canis lupus familiaris

uniprot O09044 262
type: UnificationXref
id: O09044
db: uniprot

uniprot O02495 261
type: UnificationXref
id: O02495
db: uniprot

uniprot E1C795 49
type: UnificationXref
id: E1C795
db: uniprot

MODULATION
type: RelationshipTypeVocabulary

uniprot Q62442 294
type: UnificationXref
id: Q62442
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 10

G protein subunit alpha i2
type: ProteinReference
xref: uniprot H2QMN4 112
xref: PTHR10218:SF73
organism: Pan troglodytes

uniprot P83351 282
type: UnificationXref
id: P83351
db: uniprot

ncbitaxon 367110 68
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot F7E427 92
type: UnificationXref
id: F7E427
db: uniprot

uniprot Q5BH99 188
type: UnificationXref
id: Q5BH99
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot O95721 266
organism: Homo sapiens

uniprot Q92356 301
type: UnificationXref
id: Q92356
db: uniprot

uniprot Q08462 333
type: UnificationXref
id: Q08462
db: uniprot

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

ACTH
type: Protein
entity reference: ACTH
comment: SPECIES_TYPE=PROTEIN

uniprot Q7T3D3 214
type: UnificationXref
id: Q7T3D3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HEV7 316
xref: PTHR24229:SF2
organism: Macaca mulatta

DISSOCIATION
type: RelationshipTypeVocabulary

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot Q9DC51 223
xref: PTHR10218:SF230
organism: Mus musculus

uniprot F7H6T7 104
type: UnificationXref
id: F7H6T7
db: uniprot

ncbitaxon 7668 264
type: UnificationXref
id: 7668
db: ncbitaxon

GDP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

TRANSPORT_LEFT__alpha_MSH-RIGHT__alpha_MSH-_re3
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 367
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 366
left: alpha-MSH
interaction type: TRANSPORT
right: alpha-MSH

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50150 149
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot P50151 150
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot P50154 152
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LYB4 234
xref: PTHR19957:SF34
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50153 151
organism: Mus musculus

G protein subunit alpha i1
type: ProteinReference
xref: uniprot F7FSE3 98
xref: PTHR10218:SF227
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P50146 148
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QDW1 230
xref: PTHR19957:SF34
organism: Macaca mulatta

uniprot Q29450 334
type: UnificationXref
id: Q29450
db: uniprot

Mu or Delta receptor
type: Protein
entity reference: Mu or Delta receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s47 sa5 357
feature: ACTIVE 312
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P63213 171
type: UnificationXref
id: P63213
db: uniprot

PARTICIPANT STOICHIOMETRY re7 362
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 363
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SED9 243
xref: PTHR19957:SF34
organism: Monodelphis domestica

uniprot O14775 120
type: UnificationXref
id: O14775
db: uniprot

uniprot Q7ZW82 215
type: UnificationXref
id: Q7ZW82
db: uniprot

G protein alpha subunit Gi isoform X2
type: ProteinReference
xref: PTHR10218:SF310
xref: uniprot Q8WSS1 218
organism: Ciona intestinalis

Proopiomelanocortin b
type: ProteinReference
xref: PTHR11416:SF7
xref: uniprot Q5SPP4 23
organism: Danio rerio

ncbitaxon 7719 219
type: UnificationXref
id: 7719
db: ncbitaxon

Complex (GDP/G-protein/ Mu or Kappa/beta-Endorphin)
type: Complex
component stoichiometry: beta Endorphin s21 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s17 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: G protein s19 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: Mu or Delta receptor s48 sa8 STOICHIOMETRY ID COMPLEX
component: G-protein
component: beta-Endorphin
component: GDP
component: Mu or Delta receptor
feature: COMPLEX BINDING FEATURE s26 a32 344
feature: COMPLEX BINDING FEATURE s26 a32 346
feature: COMPLEX BINDING FEATURE s26 a32 348
feature: COMPLEX BINDING FEATURE s26 a32 350
cellular location: cytosol

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot F6YMH2 249
organism: Macaca mulatta

AC
type: ProteinReference
xref: P06011
standard name: adenylate cyclase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Opioid proopiomelanocortin pathway.PROTEIN.GENERIC.AC
comment: ENTITY_REFERENCE_NOTES= Long Name: adenylate cyclase Synonym: Long Name: AC,adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclase Accession: P06011
member entity reference: Adenylate cyclase
member entity reference: Adenylate cyclase type 7
member entity reference: Adenylate cyclase type 2

STATE_TRANSITION
type: RelationshipTypeVocabulary

PTHR10218:SF302
type: RelationshipXref
id: PTHR10218:SF302
db: PANTHER Family
relationship type: By Homology

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q9BV40 302
organism: Homo sapiens

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot K7ADQ0 329
organism: Pan troglodytes

uniprot P30671 141
type: UnificationXref
id: P30671
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V6P8 105
organism: Rattus norvegicus

TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re12
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 382
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 383
left: K+
interaction type: TRANSPORT
right: K+

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot F7A943 251
organism: Monodelphis domestica

ncbitaxon 9606 12
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot F6PGC8 69
type: UnificationXref
id: F6PGC8
db: uniprot

Soluble NSF attachment protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot P83351 282
organism: Caenorhabditis elegans

ncbitaxon 9258 70
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot Q9BV40 302
type: UnificationXref
id: Q9BV40
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot H2Q9G5 111
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63219 177
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 176
organism: Homo sapiens

Pro-opiomelanocortin
type: ProteinReference
xref: PTHR11416:SF7
xref: uniprot P01189 11
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63217 175
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63216 174
organism: Mus musculus

uniprot P63096 168
type: UnificationXref
id: P63096
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 173
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63214 172
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63213 171
organism: Mus musculus

beta-Endorphin
type: Protein
entity reference: beta-Endorphin
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa11 343
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q8WSS1 218
type: UnificationXref
id: Q8WSS1
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 238

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q15KE4 181
organism: Danio rerio

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 133

STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 360
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 361
left: AC
interaction type: STATE_TRANSITION
right: AC

uniprot P23763 268
type: UnificationXref
id: P23763
db: uniprot

uniprot G2HIJ9 253
type: UnificationXref
id: G2HIJ9
db: uniprot

beta Endorphin s21 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: beta-Endorphin
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot P29829 140
organism: Drosophila melanogaster

Anaelgesia
type: Pathway

G protein subunit alpha i1
type: ProteinReference
xref: uniprot A0A2I3S4R3 26
xref: PTHR10218:SF227
organism: Pan troglodytes

Pro-opiomelanocortin
type: ProteinReference
xref: PTHR11416:SF7
xref: uniprot P01193 15
organism: Mus musculus

Pro-opiomelanocortin
type: ProteinReference
xref: PTHR11416:SF7
xref: uniprot P01190 13
organism: Bos taurus

Pro-opiomelanocortin
type: ProteinReference
xref: uniprot P01194 17
xref: PTHR11416:SF7
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7F580 96
organism: Macaca mulatta

G protein subunit alpha o1
type: ProteinReference
xref: uniprot A0A2I3TFM8 27
xref: PTHR10218:SF302
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot Q9CXP8 221
organism: Mus musculus

uniprot Q2KJD2 289
type: UnificationXref
id: Q2KJD2
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P04897 122
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P59215 157
organism: Rattus norvegicus

uniprot P62881 165
type: UnificationXref
id: P62881
db: uniprot

ACTH
type: ProteinReference
xref: P06008
standard name: Adrenocorticotropic hormone
comment: ENTITY_REFERENCE_NOTES= Long Name: corticotropin Synonym: Corticotropin ,Long Name: ACTH Accession: P06008
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Opioid proopiomelanocortin pathway.PROTEIN.GENERIC.ACTH
member entity reference: Proopiomelanocortin
member entity reference: Pro-opiomelanocortin
member entity reference: Uncharacterized protein
member entity reference: POMC isoform 1

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RGI5 54
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P04899 123
organism: Homo sapiens

uniprot H2PZK9 108
type: UnificationXref
id: H2PZK9
db: uniprot

G-protein
type: Protein
entity reference: G-protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa2 339
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: uniprot P51875 153
xref: PTHR10218:SF302
organism: Caenorhabditis elegans

uniprot A0A2J8NL92 5
type: UnificationXref
id: A0A2J8NL92
db: uniprot

ncbitaxon 8364 20
type: UnificationXref
id: 8364
db: ncbitaxon

G protein alpha o subunit
type: ProteinReference
xref: uniprot P16378 129
xref: PTHR10218:SF302
organism: Drosophila melanogaster

Synaptobrevin
type: ProteinReference
xref: uniprot P18489 267
xref: PTHR45701:SF10
organism: Drosophila melanogaster

TRANSPORT
type: RelationshipTypeVocabulary

SNAP25 homologous protein SNAP29
type: ProteinReference
xref: uniprot Q9SD96 307
organism: Arabidopsis thaliana

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 37

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 193

uniprot P63217 175
type: UnificationXref
id: P63217
db: uniprot

uniprot M9PE71 259
type: UnificationXref
id: M9PE71
db: uniprot

uniprot P50153 151
type: UnificationXref
id: P50153
db: uniprot

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P17343 132
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: uniprot P18872 136
xref: PTHR10218:SF302
organism: Mus musculus

uniprot F7FXA9 99
type: UnificationXref
id: F7FXA9
db: uniprot

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 314

uniprot Q5ZJ03 195
type: UnificationXref
id: Q5ZJ03
db: uniprot

uniprot P51829 332
type: UnificationXref
id: P51829
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3SZ98 186
organism: Bos taurus

Synaptosomal-associated protein 25-A
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q5TZ66 293
organism: Danio rerio

GO GO:0008021 3
type: UnificationXref
id: GO:0008021
db: GO

uniprot K7E376 118
type: UnificationXref
id: K7E376
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot A5PEW5 235
organism: Caenorhabditis elegans

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 44

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6SSS3 73
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q1D9 109
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6W548 79
organism: Macaca mulatta

GNAI2 protein
type: ProteinReference
xref: uniprot A7MBH9 38
xref: PTHR10218:SF73
organism: Bos taurus

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 7

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P52287 154
organism: Rattus norvegicus

uniprot Q6PBR4 204
type: UnificationXref
id: Q6PBR4
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot F6UBJ8 244
organism: Xenopus tropicalis

uniprot Q3T0Y8 290
type: UnificationXref
id: Q3T0Y8
db: uniprot

uniprot H2QLA1 257
type: UnificationXref
id: H2QLA1
db: uniprot

Synaptobrevin homolog 2
type: ProteinReference
xref: uniprot P33328 270
organism: Saccharomyces cerevisiae

uniprot H2Q3W7 110
type: UnificationXref
id: H2Q3W7
db: uniprot

uniprot A7EDU2 36
type: UnificationXref
id: A7EDU2
db: uniprot

Syntaxin-3
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot Q13277 285
organism: Homo sapiens

K+
type: SmallMolecule
comment: SPECIES_TYPE=ION

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 22

uniprot Q9W1I8 309
type: UnificationXref
id: Q9W1I8
db: uniprot

uniprot Q5I080 191
type: UnificationXref
id: Q5I080
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7AE17 117
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 47
organism: Gallus gallus

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 219

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot F6VUT7 247
organism: Ornithorhynchus anatinus

Synaptosomal-associated protein 23
type: ProteinReference
xref: uniprot O00161 260
xref: PTHR19305:SF4
organism: Homo sapiens

uniprot P31109 269
type: UnificationXref
id: P31109
db: uniprot

uniprot F7FD32 97
type: UnificationXref
id: F7FD32
db: uniprot

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7GBI0 9
type: UnificationXref
id: F7GBI0
db: uniprot

uniprot Q7Q6E0 213
type: UnificationXref
id: Q7Q6E0
db: uniprot

uniprot Q3SZ98 186
type: UnificationXref
id: Q3SZ98
db: uniprot

uniprot Q7ZT18 25
type: UnificationXref
id: Q7ZT18
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 100
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot B2RSH2 40
xref: PTHR10218:SF227
organism: Mus musculus

uniprot F7GQC5 103
type: UnificationXref
id: F7GQC5
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot A0A1D5RHE7 323
organism: Macaca mulatta

Vesicle associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot F1PRG8 241
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P08752 124
organism: Mus musculus

ncbitaxon 9913 14
type: UnificationXref
id: 9913
db: ncbitaxon

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot P08754 126
organism: Homo sapiens

ncbitaxon 7955 24
type: UnificationXref
id: 7955
db: ncbitaxon

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot P08753 125
xref: PTHR10218:SF230
organism: Rattus norvegicus

uniprot C3XY80 43
type: UnificationXref
id: C3XY80
db: uniprot

Guanine nucleotide-binding protein G(K) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot F6VL43 77
organism: Macaca mulatta

uniprot A7MBH9 38
type: UnificationXref
id: A7MBH9
db: uniprot

Mu or Delta receptor
type: ProteinReference
xref: P06004
standard name: opioid receptor, delta or mu
comment: ENTITY_REFERENCE_ID_DESC=Opioid proopiomelanocortin pathway.PROTEIN.RECEPTOR.Mu or Delta_br_receptor
comment: ENTITY_REFERENCE_NOTES= Long Name: opioid receptor, delta or mu Synonym: Synonym not specified Accession: P06004
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Mu-type opioid receptor
member entity reference: Delta-type opioid receptor
member entity reference: Opioid receptor mu 1
member entity reference: Uncharacterized protein
member entity reference: OPRD1 isoform 1

uniprot F7DL70 328
type: UnificationXref
id: F7DL70
db: uniprot

ncbitaxon 6669 58
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot P63027 279
type: UnificationXref
id: P63027
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot Q9ERB0 303
xref: PTHR19305:SF9
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DF43 199
organism: Xenopus tropicalis

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 362
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 363
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 224
organism: Homo sapiens

uniprot G5EEN8 254
type: UnificationXref
id: G5EEN8
db: uniprot

uniprot B7Q3T6 41
type: UnificationXref
id: B7Q3T6
db: uniprot

uniprot P54313 156
type: UnificationXref
id: P54313
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot Q10282 179
organism: Schizosaccharomyces pombe

Pro-opiomelanocortin protein
type: ProteinReference
xref: PTHR11416:SF7
xref: uniprot Q7ZT18 25
organism: Danio rerio

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P38400 144
organism: Canis lupus familiaris

uniprot A0A1D5QDW1 230
type: UnificationXref
id: A0A1D5QDW1
db: uniprot

uniprot P16520 131
type: UnificationXref
id: P16520
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RJB3 56
organism: Canis lupus familiaris

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 147

ncbitaxon 10090 16
type: UnificationXref
id: 10090
db: ncbitaxon

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P18851 134
organism: Saccharomyces cerevisiae

Guanine nucleotide-binding protein subunit beta-5b
type: ProteinReference
xref: uniprot Q6PBY0 205
organism: Danio rerio

Gbeta5
type: ProteinReference
xref: uniprot Q9W3J1 227
organism: Drosophila melanogaster

PTHR45701:SF6
type: RelationshipXref
id: PTHR45701:SF6
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF7
type: RelationshipXref
id: PTHR45701:SF7
db: PANTHER Family
relationship type: By Homology

G protein subunit gamma 5
type: ProteinReference
xref: uniprot H2PZA6 107
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1PJE5 65
organism: Canis lupus familiaris

PTHR45701:SF5
type: RelationshipXref
id: PTHR45701:SF5
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF3
type: RelationshipXref
id: PTHR45701:SF3
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF1
type: RelationshipXref
id: PTHR45701:SF1
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot Q9UK08 226
organism: Homo sapiens

Proopiomelanocortin
type: ProteinReference
xref: uniprot Q5M8F2 19
xref: PTHR11416:SF7
organism: Xenopus tropicalis

uniprot F7A472 86
type: UnificationXref
id: F7A472
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__beta_Endorphin-RIGHT__beta_Endorphin-_re6
control type: ACTIVATION
controller: SNARE COMPLEX

uniprot G3V6P8 105
type: UnificationXref
id: G3V6P8
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 24

uniprot P08753 125
type: UnificationXref
id: P08753
db: uniprot

SNARE COMPLEX
type: ProteinReference
xref: P06005
standard name: SNARE Complex
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: SNARE COMPLEX Synonym: Long Name: SNARE COMPLEX Accession: P06005
comment: ENTITY_REFERENCE_ID_DESC=Opioid proopiomelanocortin pathway.PROTEIN.GENERIC.SNARE COMPLEX
member entity reference: Synaptobrevin homolog 2
member entity reference: Vesicle-associated membrane protein 8
member entity reference: Synaptosomal-associated protein 29
member entity reference: Uncharacterized protein
member entity reference: Vesicle-associated membrane protein 3
member entity reference: Synaptosomal-associated protein
member entity reference: Syntaxin-3
member entity reference: Synaptobrevin-1
member entity reference: Vesicle-associated membrane protein 1
member entity reference: Vesicle associated membrane protein 1
member entity reference: Synaptosomal-associated protein 25
member entity reference: SNAP29 isoform 1
member entity reference: Vesicle-associated membrane protein 2
member entity reference: VAMP2 isoform 3
member entity reference: Vesicle associated membrane protein 8
member entity reference: SNAP25 homologous protein SNAP29
member entity reference: Synaptobrevin homolog 1
member entity reference: Neuronal synaptobrevin, isoform J
member entity reference: Syntaxin 3A
member entity reference: SNAP25 homologous protein SNAP33
member entity reference: Synaptosomal-associated protein 25-B
member entity reference: VAMP3 isoform 1
member entity reference: Synaptobrevin
member entity reference: Soluble NSF attachment protein 29
member entity reference: Putative synaptobrevin homologue SNC1/2 (Eurofung)
member entity reference: LD03592p
member entity reference: Syntaxin 3
member entity reference: Synaptosomal-associated protein 23
member entity reference: t-SNARE protein aex-4

ncbitaxon 9598 6
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot P63212 170
type: UnificationXref
id: P63212
db: uniprot

Syntaxin-3
type: ProteinReference
xref: uniprot Q08849 283
xref: PTHR19957:SF34
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re3 366
type: Stoichiometry
physical entity: alpha-MSH
stoichiometric coefficient: 1.0

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 28
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re3 367
type: Stoichiometry
physical entity: alpha-MSH
stoichiometric coefficient: 1.0

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q17QQ3 287
organism: Bos taurus

beta-Endorphin
type: Protein
entity reference: beta-Endorphin
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot P01190 13
type: UnificationXref
id: P01190
db: uniprot

uniprot F1MYW8 62
type: UnificationXref
id: F1MYW8
db: uniprot

uniprot Q5SPP4 23
type: UnificationXref
id: Q5SPP4
db: uniprot

uniprot F6YZA3 84
type: UnificationXref
id: F6YZA3
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot Q9N0Y0 305
xref: PTHR45701:SF5
organism: Macaca mulatta

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot P36975 271
organism: Drosophila melanogaster

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q3T0Y8 290
xref: PTHR45701:SF7
organism: Bos taurus

uniprot P16378 129
type: UnificationXref
id: P16378
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 84
organism: Monodelphis domestica

uniprot Q9WUF4 310
type: UnificationXref
id: Q9WUF4
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q15836 286
organism: Homo sapiens

uniprot P33533 319
type: UnificationXref
id: P33533
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot P63097 169
xref: PTHR10218:SF227
organism: Bos taurus

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot P63096 168
xref: PTHR10218:SF227
organism: Homo sapiens

uniprot Q6PBY0 205
type: UnificationXref
id: Q6PBY0
db: uniprot

Synaptosomal-associated protein 25-B
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q6PC54 297
organism: Danio rerio

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot O44419 263
organism: Strongylocentrotus purpuratus

uniprot F1LQT1 324
type: UnificationXref
id: F1LQT1
db: uniprot

K+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

uniprot Q6PHV0 298
type: UnificationXref
id: Q6PHV0
db: uniprot

Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
type: ProteinReference
xref: uniprot Q6DH55 201
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6TFY2 74
organism: Macaca mulatta

uniprot Q5TZ66 293
type: UnificationXref
id: Q5TZ66
db: uniprot

uniprot Q9ERB0 303
type: UnificationXref
id: Q9ERB0
db: uniprot

uniprot Q10282 179
type: UnificationXref
id: Q10282
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q62442 294
xref: PTHR45701:SF1
organism: Mus musculus

uniprot P62879 163
type: UnificationXref
id: P62879
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 18

PARTICIPANT STOICHIOMETRY re16 375
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 374
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ Mu or Kappa/beta-Endorphin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 377
type: Stoichiometry
physical entity: Complex (GTP/G-protein)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 376
type: Stoichiometry
physical entity: Complex (Mu or Kappa/beta-Endorphin)
stoichiometric coefficient: 1.0

uniprot H2Q1D9 109
type: UnificationXref
id: H2Q1D9
db: uniprot

uniprot Q61011 196
type: UnificationXref
id: Q61011
db: uniprot

uniprot F7HEV7 316
type: UnificationXref
id: F7HEV7
db: uniprot

PARTICIPANT STOICHIOMETRY re16 378
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 58

INHIBITION
type: RelationshipTypeVocabulary

uniprot P60879 274
type: UnificationXref
id: P60879
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63078 167
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 166
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P09471 127
organism: Homo sapiens

uniprot F6TFY2 74
type: UnificationXref
id: F6TFY2
db: uniprot

LD03592p
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9W1I8 309
organism: Drosophila melanogaster

Mu-type opioid receptor
type: ProteinReference
xref: PTHR24229:SF7
xref: uniprot P33535 320
organism: Rattus norvegicus

uniprot P54311 155
type: UnificationXref
id: P54311
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 156
organism: Rattus norvegicus

uniprot E2R2S8 52
type: UnificationXref
id: E2R2S8
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 155
organism: Rattus norvegicus

uniprot H2QZN8 114
type: UnificationXref
id: H2QZN8
db: uniprot

Putative SNAP25 homologous protein SNAP30
type: ProteinReference
xref: uniprot Q9LMG8 304
organism: Arabidopsis thaliana

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 92
organism: Ornithorhynchus anatinus

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q0V7N0 284
organism: Bos taurus

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot F6V001 326
organism: Monodelphis domestica

uniprot F7ASR8 87
type: UnificationXref
id: F7ASR8
db: uniprot

G-protein
type: Protein
entity reference: G-protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa7 347
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 206
organism: Danio rerio

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: uniprot Q7T3D3 214
xref: PTHR10218:SF227
organism: Danio rerio

GDP s17 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot F1MJV4 325
organism: Bos taurus

uniprot Q0V7N0 284
type: UnificationXref
id: Q0V7N0
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 61

uniprot F1PJE5 65
type: UnificationXref
id: F1PJE5
db: uniprot

G protein s8 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-protein
stoichiometric coefficient: 1.0

PTHR19957:SF34
type: RelationshipXref
id: PTHR19957:SF34
db: PANTHER Family
relationship type: By Homology

uniprot J9P702 116
type: UnificationXref
id: J9P702
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot A0A1D5QIS2 231
organism: Macaca mulatta

uniprot Q6PC54 297
type: UnificationXref
id: Q6PC54
db: uniprot

uniprot Q5ASG1 291
type: UnificationXref
id: Q5ASG1
db: uniprot

uniprot P50154 152
type: UnificationXref
id: P50154
db: uniprot

AC
type: Protein
entity reference: AC
feature: ACTIVE 312
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

alpha-MSH
type: Protein
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot H2R3A6 115
type: UnificationXref
id: H2R3A6
db: uniprot

uniprot A0A1D5RHE7 323
type: UnificationXref
id: A0A1D5RHE7
db: uniprot

AGAP005773-PA
type: ProteinReference
xref: uniprot A0NEH6 30
xref: PTHR10218:SF302
organism: Anopheles gambiae

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot H2Q995 256
xref: PTHR19305:SF4
organism: Pan troglodytes

uniprot F7CFG8 89
type: UnificationXref
id: F7CFG8
db: uniprot

Guanine nucleotide-binding protein (G protein), beta 5
type: ProteinReference
xref: uniprot F7EBE7 93
organism: Xenopus tropicalis

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P59768 158
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P16520 131
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6V461 76
organism: Ornithorhynchus anatinus

AC
type: Protein
entity reference: AC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q5R1X1 292
type: UnificationXref
id: Q5R1X1
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 189

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6PBR4 204
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DGZ5 200
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot J9P702 116
organism: Canis lupus familiaris

uniprot O44419 263
type: UnificationXref
id: O44419
db: uniprot

Vesicle associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot A0A2I3SR99 233
organism: Pan troglodytes

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A0A1D5QYR9 232
xref: PTHR19305:SF4
organism: Macaca mulatta

uniprot Q28024 183
type: UnificationXref
id: Q28024
db: uniprot

uniprot Q6DF43 199
type: UnificationXref
id: Q6DF43
db: uniprot

uniprot F7CDR6 315
type: UnificationXref
id: F7CDR6
db: uniprot

uniprot Q80TL1 335
type: UnificationXref
id: Q80TL1
db: uniprot

Gi alpha subunit
type: ProteinReference
xref: PTHR10218:SF310
xref: uniprot C3XY80 43
organism: Branchiostoma floridae

Opioid proopiomelanocortin pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__K_PLUS__channel-RIGHT__K_PLUS__channel-_re11
pathway component: PHYSICAL_STIMULATION
pathway component: TRANSPORT_LEFT__alpha_MSH-RIGHT__alpha_MSH-_re3
pathway component: DISSOCIATION_LEFT__Complex__GDP_G_protein__Mu_or_Kappa_beta_Endorphin_-_GTP-RIGHT__Complex__Mu_or_Kappa_beta_Endorphin_-_Complex__GTP_G_protein_-_GDP-_re16
pathway component: HETERODIMER_ASSOCIATION_LEFT__beta_Endorphin-_Complex__GDP_G_protein__Sigma,_Mu,_Kappa_-RIGHT__Complex__GDP_G_protein__Mu_or_Kappa_beta_Endorphin_-_re15
pathway component: TRANSPORT_LEFT__ACTH-RIGHT__ACTH-_re2
pathway component: DISSOCIATION_LEFT__proopiomelanocortin-RIGHT__alpha_MSH-_ACTH-_beta_Endorphin-_re1
pathway component: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re12
pathway component: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re8
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re7
pathway component: TRANSPORT_LEFT__beta_Endorphin-RIGHT__beta_Endorphin-_re6
xref: PANTHER Pathway P05917 1
comment: MODEL_NOTES=Panther Pathway: P05917 No pathway definition

Mu or Delta receptor
type: Protein
entity reference: Mu or Delta receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s49 sa10 341
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ACTIVE 312
type: EntityFeature
comment: Active state

uniprot A0A2I3SR99 233
type: UnificationXref
id: A0A2I3SR99
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot F7FXA9 99
organism: Macaca mulatta

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2b
type: ProteinReference
xref: uniprot X1WDQ5 229
xref: PTHR10218:SF73
organism: Danio rerio

uniprot P38400 144
type: UnificationXref
id: P38400
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot P29387 139
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QZN8 114
organism: Pan troglodytes

ncbitaxon 9615 51
type: UnificationXref
id: 9615
db: ncbitaxon

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot F5HMS4 242
organism: Anopheles gambiae

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 190
organism: Danio rerio

uniprot Q61016 197
type: UnificationXref
id: Q61016
db: uniprot

uniprot F6Y3N2 83
type: UnificationXref
id: F6Y3N2
db: uniprot

uniprot A0A2I3S4R3 26
type: UnificationXref
id: A0A2I3S4R3
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 135

uniprot P08754 126
type: UnificationXref
id: P08754
db: uniprot

uniprot Q3ZCA7 187
type: UnificationXref
id: Q3ZCA7
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 130

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 196
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot H2Q3R5 255
xref: PTHR19957:SF34
organism: Pan troglodytes

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__ACTH-RIGHT__ACTH-_re2
control type: ACTIVATION
controller: SNARE COMPLEX

uniprot P43425 145
type: UnificationXref
id: P43425
db: uniprot

uniprot F6VM87 246
type: UnificationXref
id: F6VM87
db: uniprot

uniprot F7G3J2 100
type: UnificationXref
id: F7G3J2
db: uniprot

uniprot F6SSS3 73
type: UnificationXref
id: F6SSS3
db: uniprot

AGAP001506-PA
type: ProteinReference
xref: uniprot Q7PXP3 209
organism: Anopheles gambiae

uniprot Q6TNT8 208
type: UnificationXref
id: Q6TNT8
db: uniprot

PTHR24229:SF2
type: RelationshipXref
id: PTHR24229:SF2
db: PANTHER Family
relationship type: By Homology

PTHR24229:SF7
type: RelationshipXref
id: PTHR24229:SF7
db: PANTHER Family
relationship type: By Homology

PTHR10218:SF227
type: RelationshipXref
id: PTHR10218:SF227
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 197
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot Q61017 198
organism: Mus musculus

GTP s6 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot P63025 277
type: UnificationXref
id: P63025
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__beta_Endorphin-_Complex__GDP_G_protein__Sigma,_Mu,_Kappa_-RIGHT__Complex__GDP_G_protein__Mu_or_Kappa_beta_Endorphin_-_re15
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 381
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 380
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 379
left: beta-Endorphin
left: Complex (GDP/G-protein/ Sigma, Mu, Kappa)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GDP/G-protein/ Mu or Kappa/beta-Endorphin)

proopiomelanocortin
type: Protein
entity reference: proopiomelanocortin
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

hyperpolarization
type: Pathway

Mu or Delta receptor s48 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Mu or Delta receptor
stoichiometric coefficient: 1.0

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9Z2P6 311
organism: Rattus norvegicus

uniprot P09471 127
type: UnificationXref
id: P09471
db: uniprot

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q9WUF4 310
xref: PTHR45701:SF7
organism: Rattus norvegicus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q5R1X1 292
xref: PTHR19305:SF5
organism: Pan troglodytes

proopiomelanocortin
type: ProteinReference
xref: P06010
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Opioid proopiomelanocortin pathway.PROTEIN.GENERIC.proopiomelanocortin
comment: ENTITY_REFERENCE_NOTES= Long Name: proopiomelanocortin Synonym: Corticotropin,Gamma-MSH,Lipotropin,Long Name: proopiomelanocortin,Melanocyte stimulating hormone,Melanotropin,POC Accession: P06010
member entity reference: Proopiomelanocortin
member entity reference: Pro-opiomelanocortin
member entity reference: Proopiomelanocortin b
member entity reference: Uncharacterized protein
member entity reference: Pro-opiomelanocortin protein
member entity reference: POMC isoform 1

uniprot F7CXD0 91
type: UnificationXref
id: F7CXD0
db: uniprot

synaptic vesicle
type: CellularLocationVocabulary
xref: GO GO:0008021 3

PTHR10218:SF230
type: RelationshipXref
id: PTHR10218:SF230
db: PANTHER Family
relationship type: By Homology

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 20

uniprot F6VL43 77
type: UnificationXref
id: F6VL43
db: uniprot

TRIGGER
type: RelationshipTypeVocabulary

uniprot P04899 123
type: UnificationXref
id: P04899
db: uniprot

PARTICIPANT STOICHIOMETRY re6 365
type: Stoichiometry
physical entity: beta-Endorphin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re6 364
type: Stoichiometry
physical entity: beta-Endorphin
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot O14610 119
organism: Homo sapiens

uniprot P42866 322
type: UnificationXref
id: P42866
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P49177 146
organism: Arabidopsis thaliana

uniprot Q9UBI6 225
type: UnificationXref
id: Q9UBI6
db: uniprot

beta-Endorphin
type: Protein
entity reference: beta-Endorphin
comment: SPECIES_TYPE=PROTEIN

Golgi apparatus
type: CellularLocationVocabulary
xref: GO GO:0005794 4

ncbitaxon 7739 44
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot P41143 321
type: UnificationXref
id: P41143
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 128
organism: Bos taurus

Mu-type opioid receptor
type: ProteinReference
xref: uniprot F1N5B6 313
xref: PTHR24229:SF7
organism: Bos taurus

uniprot P63044 280
type: UnificationXref
id: P63044
db: uniprot

uniprot A4IGZ2 34
type: UnificationXref
id: A4IGZ2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T7 104
organism: Macaca mulatta

eco ECO:0000250 7
type: UnificationXref
id: ECO:0000250
db: eco

uniprot H2PZA6 107
type: UnificationXref
id: H2PZA6
db: uniprot

uniprot P50151 150
type: UnificationXref
id: P50151
db: uniprot

uniprot K7ADQ0 329
type: UnificationXref
id: K7ADQ0
db: uniprot

uniprot P52287 154
type: UnificationXref
id: P52287
db: uniprot

uniprot P18489 267
type: UnificationXref
id: P18489
db: uniprot

Vesicle associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot E2QUL2 239
organism: Canis lupus familiaris

ncbitaxon 284812 180
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot H2RCB8 258
type: UnificationXref
id: H2RCB8
db: uniprot

Guanine nucleotide-binding protein G(O) subunit alpha isoform a
type: ProteinReference
xref: uniprot F7GQC5 103
xref: PTHR10218:SF302
organism: Macaca mulatta

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot F5HH30 67
organism: Neurospora crassa

beta-Endorphin
type: ProteinReference
xref: P06006
comment: ENTITY_REFERENCE_ID_DESC=Opioid proopiomelanocortin pathway.PROTEIN.GENERIC.beta-Endorphin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: beta-Endorphin Synonym: Long Name: beta-Endorphin Accession: P06006
member entity reference: Proopiomelanocortin
member entity reference: Pro-opiomelanocortin
member entity reference: Proopiomelanocortin b
member entity reference: Uncharacterized protein
member entity reference: Pro-opiomelanocortin protein
member entity reference: POMC isoform 1

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P43425 145
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IGZ2 34
organism: Xenopus tropicalis

uniprot P18872 136
type: UnificationXref
id: P18872
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q28024 183
organism: Bos taurus

uniprot Q64704 296
type: UnificationXref
id: Q64704
db: uniprot

uniprot D3ZLD6 46
type: UnificationXref
id: D3ZLD6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XWE8 82
organism: Monodelphis domestica

eco ECO:0000305 236
type: UnificationXref
id: ECO:0000305
db: eco

uniprot A0A3Q1NGS8 29
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot Q92356 301
organism: Schizosaccharomyces pombe

AGAP005904-PA
type: ProteinReference
xref: PTHR10218:SF310
xref: uniprot Q7Q6E0 213
organism: Anopheles gambiae

AGAP005911-PA
type: ProteinReference
xref: uniprot Q7Q6D4 212
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F6UJE8 75
organism: Monodelphis domestica

AGAP005913-PA
type: ProteinReference
xref: uniprot Q7Q6D2 210
organism: Anopheles gambiae

uniprot F7ES96 95
type: UnificationXref
id: F7ES96
db: uniprot

AGAP005912-PA
type: ProteinReference
xref: uniprot Q7Q6D3 211
organism: Anopheles gambiae

uniprot P63218 176
type: UnificationXref
id: P63218
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 14

uniprot F1PRG8 241
type: UnificationXref
id: F1PRG8
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 70

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q3W7 110
organism: Pan troglodytes

PANTHER Pathway P05917 1
type: UnificationXref
id: P05917
db: PANTHER Pathway

uniprot Q08849 283
type: UnificationXref
id: Q08849
db: uniprot

ncbitaxon 6239 133
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot Q5M8F2 19
type: UnificationXref
id: Q5M8F2
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q28H40 184
organism: Xenopus tropicalis

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P30671 141
organism: Bos taurus

uniprot Q7ZUC1 300
type: UnificationXref
id: Q7ZUC1
db: uniprot

G protein alpha i subunit
type: ProteinReference
xref: PTHR10218:SF310
xref: uniprot P20353 137
organism: Drosophila melanogaster

uniprot F6PVT7 71
type: UnificationXref
id: F6PVT7
db: uniprot

uniprot P17343 132
type: UnificationXref
id: P17343
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 42

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Anaelgesia
controller: K+ channel

By Homology
type: RelationshipTypeVocabulary

uniprot E2R9G5 53
type: UnificationXref
id: E2R9G5
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot F1A421 60
organism: Dictyostelium purpureum

uniprot F6UBJ8 244
type: UnificationXref
id: F6UBJ8
db: uniprot

uniprot Q9LMG8 304
type: UnificationXref
id: Q9LMG8
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 51

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NGS8 29
organism: Bos taurus

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 113
organism: Pan troglodytes

PTHR11416:SF7
type: RelationshipXref
id: PTHR11416:SF7
db: PANTHER Family
relationship type: By Homology

uniprot P11017 128
type: UnificationXref
id: P11017
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7G7I9 101
organism: Ornithorhynchus anatinus

SNARE COMPLEX
type: Protein
entity reference: SNARE COMPLEX
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot E2RHY4 55
type: UnificationXref
id: E2RHY4
db: uniprot

uniprot Q63666 295
type: UnificationXref
id: Q63666
db: uniprot

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot Q80TL1 335
organism: Mus musculus

VAMP3 isoform 1
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot G2HIJ9 253
organism: Pan troglodytes

uniprot F7EBE7 93
type: UnificationXref
id: F7EBE7
db: uniprot

PTHR45701:SF10
type: RelationshipXref
id: PTHR45701:SF10
db: PANTHER Family
relationship type: By Homology

uniprot E1BW98 47
type: UnificationXref
id: E1BW98
db: uniprot

uniprot H2PYH8 317
type: UnificationXref
id: H2PYH8
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot E2R907 240
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7CFG8 89
organism: Monodelphis domestica

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 48

uniprot P49177 146
type: UnificationXref
id: P49177
db: uniprot

uniprot F1N5B6 313
type: UnificationXref
id: F1N5B6
db: uniprot

uniprot P51875 153
type: UnificationXref
id: P51875
db: uniprot

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot P51828 331
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7GI54 102
organism: Monodelphis domestica

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot P51829 332
organism: Mus musculus

beta Endorphin s23 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: beta-Endorphin
stoichiometric coefficient: 1.0

uniprot P63097 169
type: UnificationXref
id: P63097
db: uniprot

DISSOCIATION_LEFT__Complex__GDP_G_protein__Mu_or_Kappa_beta_Endorphin_-_GTP-RIGHT__Complex__Mu_or_Kappa_beta_Endorphin_-_Complex__GTP_G_protein_-_GDP-_re16
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 374
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 377
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 378
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 376
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 375
left: GTP
left: Complex (GDP/G-protein/ Mu or Kappa/beta-Endorphin)
interaction type: DISSOCIATION
right: Complex (GTP/G-protein)
right: GDP
right: Complex (Mu or Kappa/beta-Endorphin)

uniprot P01194 17
type: UnificationXref
id: P01194
db: uniprot

ncbitaxon 10116 18
type: UnificationXref
id: 10116
db: ncbitaxon

SNAP25 homologous protein SNAP33
type: ProteinReference
xref: uniprot Q9S7P9 306
organism: Arabidopsis thaliana

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot Q9VH76 308
organism: Drosophila melanogaster

uniprot P63078 167
type: UnificationXref
id: P63078
db: uniprot

PARTICIPANT STOICHIOMETRY re1 371
type: Stoichiometry
physical entity: alpha-MSH
stoichiometric coefficient: 1.0

uniprot F6RIM7 72
type: UnificationXref
id: F6RIM7
db: uniprot

PARTICIPANT STOICHIOMETRY re1 370
type: Stoichiometry
physical entity: proopiomelanocortin
stoichiometric coefficient: 1.0

Gnb3 protein
type: ProteinReference
xref: uniprot Q6P025 202
organism: Danio rerio

PARTICIPANT STOICHIOMETRY re1 373
type: Stoichiometry
physical entity: beta-Endorphin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 372
type: Stoichiometry
physical entity: ACTH
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5KI86 192
organism: Cryptococcus neoformans

Guanine nucleotide binding protein, beta subunit
type: ProteinReference
xref: uniprot E9FUX0 57
organism: Daphnia pulex

uniprot Q80SZ7 217
type: UnificationXref
id: Q80SZ7
db: uniprot

uniprot Q20636 182
type: UnificationXref
id: Q20636
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha-activating activity polypeptide O, b
type: ProteinReference
xref: uniprot Q6P967 203
xref: PTHR10218:SF331
organism: Danio rerio

uniprot A0A1D5QIS2 231
type: UnificationXref
id: A0A1D5QIS2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9UBI6 225
organism: Homo sapiens

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot Q29450 334
organism: Bos taurus

Mu or Delta receptor s47 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Mu or Delta receptor
stoichiometric coefficient: 1.0

uniprot Q9DC51 223
type: UnificationXref
id: Q9DC51
db: uniprot

uniprot Q9DAS9 222
type: UnificationXref
id: Q9DAS9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 71
organism: Monodelphis domestica

uniprot F6V001 326
type: UnificationXref
id: F6V001
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 83
organism: Monodelphis domestica

THO complex subunit, putative
type: ProteinReference
xref: uniprot B7Q3T6 41
organism: Ixodes scapularis

Delta-type opioid receptor
type: ProteinReference
xref: uniprot P32300 318
xref: PTHR24229:SF2
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XHP0 81
organism: Macaca mulatta

uniprot P29387 139
type: UnificationXref
id: P29387
db: uniprot

uniprot A5PKD6 35
type: UnificationXref
id: A5PKD6
db: uniprot

beta-Endorphin
type: Protein
entity reference: beta-Endorphin
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa9 351
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9DAS9 222
organism: Mus musculus

uniprot P63216 174
type: UnificationXref
id: P63216
db: uniprot

uniprot P32300 318
type: UnificationXref
id: P32300
db: uniprot

uniprot A0NEH6 30
type: UnificationXref
id: A0NEH6
db: uniprot

uniprot A0A2I3TFM8 27
type: UnificationXref
id: A0A2I3TFM8
db: uniprot

uniprot Q6TH03 207
type: UnificationXref
id: Q6TH03
db: uniprot

uniprot P33535 320
type: UnificationXref
id: P33535
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ASR8 87
organism: Macaca mulatta

uniprot A1L271 32
type: UnificationXref
id: A1L271
db: uniprot

uniprot A8X8S6 237
type: UnificationXref
id: A8X8S6
db: uniprot

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P26308 138
organism: Drosophila melanogaster

uniprot B2RSH2 40
type: UnificationXref
id: B2RSH2
db: uniprot

uniprot P62872 160
type: UnificationXref
id: P62872
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CXD0 91
organism: Monodelphis domestica

G-protein beta subunit
type: ProteinReference
xref: uniprot Q5BH99 188
organism: Emericella nidulans

uniprot P63215 173
type: UnificationXref
id: P63215
db: uniprot

G protein s19 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-protein
stoichiometric coefficient: 1.0

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot F6VM87 246
organism: Monodelphis domestica

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: stress response
controller: ACTH

PARTICIPANT STOICHIOMETRY re15 381
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ Mu or Kappa/beta-Endorphin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re12 382
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re15 380
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ Sigma, Mu, Kappa)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re12 383
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

uniprot P36408 142
type: UnificationXref
id: P36408
db: uniprot

PARTICIPANT STOICHIOMETRY re15 379
type: Stoichiometry
physical entity: beta-Endorphin
stoichiometric coefficient: 1.0

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 31

uniprot X1WDQ5 229
type: UnificationXref
id: X1WDQ5
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 62
organism: Bos taurus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: hyperpolarization
controller: K+ channel

uniprot Q17QQ3 287
type: UnificationXref
id: Q17QQ3
db: uniprot

uniprot Q5KI86 192
type: UnificationXref
id: Q5KI86
db: uniprot

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot P26769 330
organism: Rattus norvegicus

Synaptosomal-associated protein 23
type: ProteinReference
xref: uniprot O09044 262
xref: PTHR19305:SF4
organism: Mus musculus

uniprot E9FUX0 57
type: UnificationXref
id: E9FUX0
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7BB02 88
organism: Macaca mulatta

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 216
organism: Danio rerio

uniprot Q9W3J1 227
type: UnificationXref
id: Q9W3J1
db: uniprot

ncbitaxon 227321 189
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot H2Q3R5 255
type: UnificationXref
id: H2Q3R5
db: uniprot

uniprot F7GI54 102
type: UnificationXref
id: F7GI54
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot A8X8S6 237
organism: Caenorhabditis briggsae

uniprot P62871 159
type: UnificationXref
id: P62871
db: uniprot

uniprot F2Z3T8 66
type: UnificationXref
id: F2Z3T8
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q63666 295
xref: PTHR45701:SF1
organism: Rattus norvegicus

uniprot E2R2S3 50
type: UnificationXref
id: E2R2S3
db: uniprot

uniprot P51828 331
type: UnificationXref
id: P51828
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot Q7SZZ5 299
organism: Danio rerio

uniprot Q6P967 203
type: UnificationXref
id: Q6P967
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3KRE3 185
organism: Rattus norvegicus

uniprot P62873 161
type: UnificationXref
id: P62873
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot E2RHY4 55
organism: Canis lupus familiaris

G-protein
type: ProteinReference
xref: P06012
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Opioid proopiomelanocortin pathway.PROTEIN.GENERIC.G-protein
comment: ENTITY_REFERENCE_NOTES= Long Name: G-protein Synonym: Synonym not specified Accession: P06012
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
member entity reference: G protein alpha subunit Gi isoform X2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: AGAP001506-PA
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
member entity reference: AGAP005913-PA
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-activating activity polypeptide O, b
member entity reference: Guanine nucleotide-binding protein subunit beta-2
member entity reference: GNB4 protein
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2b
member entity reference: G protein subunit alpha o1
member entity reference: Guanine nucleotide binding protein, beta subunit
member entity reference: Uncharacterized protein
member entity reference: Gnb1l protein
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
member entity reference: G protein subunit beta 4
member entity reference: Gnb2 protein
member entity reference: THO complex subunit, putative
member entity reference: G protein subunit beta 2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
member entity reference: G protein subunit alpha i1
member entity reference: Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
member entity reference: Guanine nucleotide-binding protein subunit beta-5b
member entity reference: Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: G protein subunit beta 1
member entity reference: Guanine nucleotide-binding protein subunit beta-5
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: G protein alpha i subunit
member entity reference: Gnb3 protein
member entity reference: Guanine nucleotide-binding protein G(K) subunit alpha
member entity reference: Gi alpha subunit
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-2
member entity reference: G protein subunit alpha i3
member entity reference: G protein subunit beta 3
member entity reference: Guanine nucleotide-binding protein subunit beta-1
member entity reference: Guanine nucleotide-binding protein G(o) subunit alpha
member entity reference: AGAP005773-PA
member entity reference: Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
member entity reference: Guanine nucleotide-binding protein (G protein), beta 5

uniprot Q95J84 21
type: UnificationXref
id: Q95J84
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot O60262 121
organism: Homo sapiens

uniprot H2Q9G5 111
type: UnificationXref
id: H2Q9G5
db: uniprot

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
type: ProteinReference
xref: uniprot Q3ZCA7 187
xref: PTHR10218:SF230
organism: Bos taurus

uniprot F7A943 251
type: UnificationXref
id: F7A943
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot D3ZLD6 46
organism: Rattus norvegicus

uniprot P63077 166
type: UnificationXref
id: P63077
db: uniprot

PTHR19305:SF5
type: RelationshipXref
id: PTHR19305:SF5
db: PANTHER Family
relationship type: By Homology

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 180

uniprot Q28H40 184
type: UnificationXref
id: Q28H40
db: uniprot

PTHR19305:SF9
type: RelationshipXref
id: PTHR19305:SF9
db: PANTHER Family
relationship type: By Homology

uniprot Q7Q6D3 211
type: UnificationXref
id: Q7Q6D3
db: uniprot

uniprot A0A2I3TUD1 28
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

PARTICIPANT STOICHIOMETRY re11 358
type: Stoichiometry
physical entity: K+ channel
stoichiometric coefficient: 1.0

uniprot E2QUL2 239
type: UnificationXref
id: E2QUL2
db: uniprot

PARTICIPANT STOICHIOMETRY re11 359
type: Stoichiometry
physical entity: K+ channel
stoichiometric coefficient: 1.0

Mu-type opioid receptor
type: ProteinReference
xref: uniprot P42866 322
xref: PTHR24229:SF7
organism: Mus musculus

ncbitaxon 13616 22
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot Q28HP6 288
type: UnificationXref
id: Q28HP6
db: uniprot

uniprot Q7SZZ5 299
type: UnificationXref
id: Q7SZZ5
db: uniprot

PTHR19305:SF4
type: RelationshipXref
id: PTHR19305:SF4
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: stress response
controller: alpha-MSH

uniprot Q9Z2P6 311
type: UnificationXref
id: Q9Z2P6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q0VFC4 178
organism: Xenopus tropicalis

uniprot F1A421 60
type: UnificationXref
id: F1A421
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6TH03 207
organism: Danio rerio

uniprot Q7Q6D2 210
type: UnificationXref
id: Q7Q6D2
db: uniprot

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa1 337
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot Q20636 182
organism: Caenorhabditis elegans

ncbitaxon 665079 37
type: UnificationXref
id: 665079
db: ncbitaxon

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re12
control type: ACTIVATION
controller: K+ channel

uniprot F5HH30 67
type: UnificationXref
id: F5HH30
db: uniprot

uniprot F6UJE8 75
type: UnificationXref
id: F6UJE8
db: uniprot

GNB4 protein
type: ProteinReference
xref: uniprot A5PKD6 35
organism: Bos taurus

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__alpha_MSH-RIGHT__alpha_MSH-_re3
control type: ACTIVATION
controller: SNARE COMPLEX

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 12

ncbitaxon 3702 147
type: UnificationXref
id: 3702
db: ncbitaxon

ncbitaxon 7227 130
type: UnificationXref
id: 7227
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot F7FD32 97
organism: Macaca mulatta

uniprot O60262 121
type: UnificationXref
id: O60262
db: uniprot

uniprot Q6DGZ5 200
type: UnificationXref
id: Q6DGZ5
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot Q28HP6 288
xref: PTHR19305:SF5
organism: Xenopus tropicalis

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot Q7ZW82 215
organism: Danio rerio

uniprot P60880 275
type: UnificationXref
id: P60880
db: uniprot

alpha-MSH
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot P01193 15
type: UnificationXref
id: P01193
db: uniprot

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 264

uniprot C3ZSF0 45
type: UnificationXref
id: C3ZSF0
db: uniprot

uniprot F7FSE3 98
type: UnificationXref
id: F7FSE3
db: uniprot

uniprot Q7Q6D4 212
type: UnificationXref
id: Q7Q6D4
db: uniprot

uniprot E2RJB3 56
type: UnificationXref
id: E2RJB3
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E1C795 49
organism: Gallus gallus

uniprot Q0VFC4 178
type: UnificationXref
id: Q0VFC4
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot R4GKD1 228
organism: Gallus gallus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 95
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NLV4 63
organism: Gallus gallus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V8K2 106
organism: Rattus norvegicus

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot P31109 269
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY re8 360
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re8 361
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

K+ channel
type: Protein
feature: ACTIVE 312
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F5HMS4 242
type: UnificationXref
id: F5HMS4
db: uniprot

PTHR10218:SF73
type: RelationshipXref
id: PTHR10218:SF73
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9031 48
type: UnificationXref
id: 9031
db: ncbitaxon

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot A7EDU2 36
organism: Sclerotinia sclerotiorum

TRANSPORT_LEFT__beta_Endorphin-RIGHT__beta_Endorphin-_re6
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 365
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 364
left: beta-Endorphin
interaction type: TRANSPORT
right: beta-Endorphin

uniprot F6ZAV4 327
type: UnificationXref
id: F6ZAV4
db: uniprot

uniprot Q6P025 202
type: UnificationXref
id: Q6P025
db: uniprot

uniprot A4IFL6 33
type: UnificationXref
id: A4IFL6
db: uniprot

SNAP29 isoform 1
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot H2QLA1 257
organism: Pan troglodytes

G protein subunit alpha i3
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot Q5I080 191
organism: Xenopus tropicalis

P06010
type: UnificationXref
id: P06010
db: PANTHER Pathway Component

Opioid receptor mu 1
type: ProteinReference
xref: PTHR24229:SF7
xref: uniprot F7CDR6 315
organism: Monodelphis domestica

PTHR45627:SF9
type: RelationshipXref
id: PTHR45627:SF9
db: PANTHER Family
relationship type: By Homology

P06012
type: UnificationXref
id: P06012
db: PANTHER Pathway Component

K+ channel
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

P06011
type: UnificationXref
id: P06011
db: PANTHER Pathway Component

uniprot P63219 177
type: UnificationXref
id: P63219
db: uniprot

PTHR45627:SF6
type: RelationshipXref
id: PTHR45627:SF6
db: PANTHER Family
relationship type: By Homology

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 143

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F2Z3T8 66
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot Q6PH57 206
type: UnificationXref
id: Q6PH57
db: uniprot

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 236

uniprot P36975 271
type: UnificationXref
id: P36975
db: uniprot

uniprot Q13277 285
type: UnificationXref
id: Q13277
db: uniprot

uniprot F6V461 76
type: UnificationXref
id: F6V461
db: uniprot

stress response
type: Pathway

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7E376 118
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 217
organism: Mus musculus

POMC isoform 1
type: ProteinReference
xref: uniprot A0A2J8NL92 5
xref: PTHR11416:SF7
organism: Pan troglodytes

Complex (GDP/G-protein/ Sigma, Mu, Kappa)
type: Complex
component stoichiometry: Mu or Delta receptor s47 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: G protein s14 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s13 sa3 STOICHIOMETRY ID COMPLEX
component: G-protein
component: GDP
component: Mu or Delta receptor
feature: COMPLEX BINDING FEATURE s11 a15 352
feature: COMPLEX BINDING FEATURE s11 a15 354
feature: COMPLEX BINDING FEATURE s11 a15 356
cellular location: cytosol

uniprot Q9UK08 226
type: UnificationXref
id: Q9UK08
db: uniprot

ncbitaxon 44689 143
type: UnificationXref
id: 44689
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q90Z40 220
organism: Danio rerio

uniprot P26769 330
type: UnificationXref
id: P26769
db: uniprot

uniprot Q803H5 216
type: UnificationXref
id: Q803H5
db: uniprot

uniprot A5PEW5 235
type: UnificationXref
id: A5PEW5
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 85
organism: Macaca mulatta

TRANSPORT_LEFT__ACTH-RIGHT__ACTH-_re2
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 369
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 368
left: ACTH
interaction type: TRANSPORT
right: ACTH

uniprot H2QNS5 113
type: UnificationXref
id: H2QNS5
db: uniprot

uniprot H2QMN4 112
type: UnificationXref
id: H2QMN4
db: uniprot

t-SNARE protein aex-4
type: ProteinReference
xref: uniprot G5EEN8 254
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GBI0 9
xref: PTHR11416:SF7
organism: Macaca mulatta

Delta-type opioid receptor
type: ProteinReference
xref: PTHR24229:SF2
xref: uniprot P41143 321
organism: Homo sapiens

uniprot A9JTC8 39
type: UnificationXref
id: A9JTC8
db: uniprot

uniprot A0A1D5QYR9 232
type: UnificationXref
id: A0A1D5QYR9
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot P23763 268
xref: PTHR45701:SF1
organism: Homo sapiens

G protein subunit beta 3
type: ProteinReference
xref: uniprot H2R3A6 115
organism: Pan troglodytes

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa3 353
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P50150 149
type: UnificationXref
id: P50150
db: uniprot

uniprot P60878 273
type: UnificationXref
id: P60878
db: uniprot

uniprot P01189 11
type: UnificationXref
id: P01189
db: uniprot

GTP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot F6ZAV4 327
organism: Ornithorhynchus anatinus

uniprot F6WNJ9 80
type: UnificationXref
id: F6WNJ9
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: uniprot F7A472 86
xref: PTHR10218:SF227
organism: Xenopus tropicalis

uniprot P18851 134
type: UnificationXref
id: P18851
db: uniprot

uniprot R4GKD1 228
type: UnificationXref
id: R4GKD1
db: uniprot

DISSOCIATION_LEFT__proopiomelanocortin-RIGHT__alpha_MSH-_ACTH-_beta_Endorphin-_re1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 371
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 372
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 370
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 373
left: proopiomelanocortin
interaction type: DISSOCIATION
right: beta-Endorphin
right: alpha-MSH
right: ACTH

uniprot Q15836 286
type: UnificationXref
id: Q15836
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

OPRD1 isoform 1
type: ProteinReference
xref: PTHR24229:SF2
xref: uniprot H2PYH8 317
organism: Pan troglodytes

TRANSPORT
type: InteractionVocabulary

uniprot P29829 140
type: UnificationXref
id: P29829
db: uniprot

uniprot G3V8K2 106
type: UnificationXref
id: G3V8K2
db: uniprot

P06004
type: UnificationXref
id: P06004
db: PANTHER Pathway Component

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot F7DL70 328
organism: Macaca mulatta

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re8
control type: INHIBITION
controller: Complex (GTP/G-protein)

P06005
type: UnificationXref
id: P06005
db: PANTHER Pathway Component

uniprot O95721 266
type: UnificationXref
id: O95721
db: uniprot

P06008
type: UnificationXref
id: P06008
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re2 369
type: Stoichiometry
physical entity: ACTH
stoichiometric coefficient: 1.0

P06006
type: UnificationXref
id: P06006
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re2 368
type: Stoichiometry
physical entity: ACTH
stoichiometric coefficient: 1.0

ncbitaxon 5786 61
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot E2R907 240
type: UnificationXref
id: E2R907
db: uniprot

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

eco ECO:0000245 314
type: UnificationXref
id: ECO:0000245
db: eco

uniprot P62880 164
type: UnificationXref
id: P62880
db: uniprot

uniprot P59215 157
type: UnificationXref
id: P59215
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re7
controller: AC

uniprot Q5XGD8 194
type: UnificationXref
id: Q5XGD8
db: uniprot

uniprot F7BB02 88
type: UnificationXref
id: F7BB02
db: uniprot

uniprot P08752 124
type: UnificationXref
id: P08752
db: uniprot

Syntaxin 3A
type: ProteinReference
xref: uniprot Q6PHV0 298
xref: PTHR19957:SF34
organism: Danio rerio

uniprot Q5BJ11 190
type: UnificationXref
id: Q5BJ11
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ERP8 94
organism: Ornithorhynchus anatinus

uniprot Q9SD96 307
type: UnificationXref
id: Q9SD96
db: uniprot

uniprot P04897 122
type: UnificationXref
id: P04897
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6VPY1 78
organism: Ornithorhynchus anatinus

ncbitaxon 6238 238
type: UnificationXref
id: 6238
db: ncbitaxon

Syntaxin 3
type: ProteinReference
xref: uniprot F7EPG4 252
xref: PTHR19957:SF34
organism: Ornithorhynchus anatinus

uniprot F6XYX9 248
type: UnificationXref
id: F6XYX9
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P36408 142
organism: Dictyostelium discoideum

uniprot K7AE17 117
type: UnificationXref
id: K7AE17
db: uniprot