uniprot B8XIA5 71
type: UnificationXref
id: B8XIA5
db: uniprot

uniprot Q9HBH9 376
type: UnificationXref
id: Q9HBH9
db: uniprot

ncbitaxon 7227 52
type: UnificationXref
id: 7227
db: ncbitaxon

Phospholipase A2
type: ProteinReference
evidence: Evidence 312
xref: PTHR10728:SF13
xref: uniprot H2Q0T0 318
organism: Pan troglodytes

uniprot P28562 212
type: UnificationXref
id: P28562
db: uniprot

uniprot P19419 359
type: UnificationXref
id: P19419
db: uniprot

CHOP s61 a87 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 2

uniprot A0A2I3TMM0 99
type: UnificationXref
id: A0A2I3TMM0
db: uniprot

uniprot Q60969 239
type: UnificationXref
id: Q60969
db: uniprot

uniprot P91664 310
type: UnificationXref
id: P91664
db: uniprot

uniprot P79996 131
type: UnificationXref
id: P79996
db: uniprot

ncbitaxon 8364 21
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot P52164 308
type: UnificationXref
id: P52164
db: uniprot

uniprot P47811 342
type: UnificationXref
id: P47811
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P79996 131
xref: PTHR24055:SF172
organism: Gallus gallus

Eukaryotic elongation factor 2 kinase
type: ProteinReference
xref: PTHR45992:SF3
xref: uniprot E2RIJ6 90
organism: Canis lupus familiaris

uniprot P05627 298
type: UnificationXref
id: P05627
db: uniprot

uniprot F6Y4G8 123
type: UnificationXref
id: F6Y4G8
db: uniprot

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot H2QS06 196
organism: Pan troglodytes

Puckered, isoform A
type: ProteinReference
xref: uniprot Q9VHV8 286
organism: Drosophila melanogaster

uniprot P01108 74
type: UnificationXref
id: P01108
db: uniprot

uniprot Q9VUG9 64
type: UnificationXref
id: Q9VUG9
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 24

uniprot F6UQ33 314
type: UnificationXref
id: F6UQ33
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YR54 174
organism: Monodelphis domestica

uniprot P17325 299
type: UnificationXref
id: P17325
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_JNK1_2-RIGHT__JNK1_2-_ADP-_r7
controller: MKK4

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7C798 335
xref: PTHR24055:SF109
organism: Macaca mulatta

Phospholipase A2
type: ProteinReference
evidence: Evidence 312
xref: uniprot F7CBU9 315
xref: PTHR10728:SF13
organism: Monodelphis domestica

uniprot P50393 324
type: UnificationXref
id: P50393
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Stat1-RIGHT__ADP-_Stat1-_r31
controller: Unknown

uniprot A0A3Q1LTT9 326
type: UnificationXref
id: A0A3Q1LTT9
db: uniprot

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot Q2YDV1 232
organism: Rattus norvegicus

Dual specificity protein phosphatase lip-1
type: ProteinReference
xref: uniprot V6CIV8 293
organism: Caenorhabditis elegans

uniprot H2Q0T0 318
type: UnificationXref
id: H2Q0T0
db: uniprot

Oxidative Stress ROS, UV
type: PhysicalEntity
comment: SPECIES_TYPE=UNKNOWN

uniprot A0A3Q1LJZ7 325
type: UnificationXref
id: A0A3Q1LJZ7
db: uniprot

TRX
type: Protein
entity reference: TRX
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 389
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q17QJ3 225
type: UnificationXref
id: Q17QJ3
db: uniprot

uniprot Q64346 242
type: UnificationXref
id: Q64346
db: uniprot

Dual-specificity phosphatase 16
type: ProteinReference
xref: uniprot Q6PCP3 246
organism: Mus musculus

Max s8 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Max
stoichiometric coefficient: 1.0

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot Q7T2L8 251
organism: Danio rerio

GO GO:0005829 3
type: UnificationXref
id: GO:0005829
db: GO

uniprot D3ZBG7 157
type: UnificationXref
id: D3ZBG7
db: uniprot

uniprot Q2T9T7 231
type: UnificationXref
id: Q2T9T7
db: uniprot

uniprot P42224 87
type: UnificationXref
id: P42224
db: uniprot

PANTHER Pathway P00046 1
type: UnificationXref
id: P00046
db: PANTHER Pathway

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot O77627 296
organism: Bos taurus

Dual specificity protein phosphatase 26
type: ProteinReference
xref: uniprot F6RW93 171
organism: Macaca mulatta

uniprot O61443 340
type: UnificationXref
id: O61443
db: uniprot

cPLA2
type: Protein
entity reference: cPLA2
feature: ACTIVE 32
feature: cPLA2 s50 a38 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot E2RKA7 329
type: UnificationXref
id: E2RKA7
db: uniprot

PTHR10159:SF299
type: RelationshipXref
id: PTHR10159:SF299
db: PANTHER Family
relationship type: By Homology

MYC associated factor X
type: ProteinReference
xref: PTHR10328:SF3
xref: uniprot F7BWL6 305
organism: Ornithorhynchus anatinus

ATF-2
type: Protein
feature: ATF 2 s43 a51 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 34

uniprot P49950 69
type: UnificationXref
id: P49950
db: uniprot

ncbitaxon 9544 5
type: UnificationXref
id: 9544
db: ncbitaxon

MYC associated factor X
type: ProteinReference
xref: PTHR10328:SF3
xref: uniprot A0A2I3TFR7 301
organism: Pan troglodytes

uniprot F7AGV5 17
type: UnificationXref
id: F7AGV5
db: uniprot

Dual specificity phosphatase 15
type: ProteinReference
xref: uniprot A0A2I3TE39 146
organism: Pan troglodytes

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot Q7PV94 250
organism: Anopheles gambiae

MNK1 2 s49 a40 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CHOP s60 a86 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot A4GTP4 358
organism: Rattus norvegicus

uniprot Q62767 240
type: UnificationXref
id: Q62767
db: uniprot

uniprot A4IFJ5 311
type: UnificationXref
id: A4IFJ5
db: uniprot

DNA damage-inducible transcript 3 protein
type: ProteinReference
xref: PTHR16833:SF0
xref: uniprot A0A2J8KW39 137
organism: Pan troglodytes

uniprot Q16829 224
type: UnificationXref
id: Q16829
db: uniprot

Os01g0390900 protein
type: ProteinReference
xref: uniprot Q5VNG7 235
organism: Oryza sativa

uniprot Q5FVI9 233
type: UnificationXref
id: Q5FVI9
db: uniprot

Dual specificity protein phosphatase 12
type: ProteinReference
xref: uniprot Q9D0T2 268
organism: Mus musculus

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot O42376 339
xref: PTHR24055:SF146
organism: Danio rerio

uniprot F7FRM2 183
type: UnificationXref
id: F7FRM2
db: uniprot

Thioredoxin
type: ProteinReference
xref: uniprot Q7KQL8 56
organism: Plasmodium falciparum

uniprot Q10038 219
type: UnificationXref
id: Q10038
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 7

Myc proto-oncogene protein
type: ProteinReference
xref: PTHR45851:SF1
xref: uniprot P09416 76
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_ATF_2-RIGHT__ATF_2-_ADP-_r24
controller: p38

Serine/threonine/tyrosine-interacting protein
type: ProteinReference
xref: uniprot Q8WUJ0 259
organism: Homo sapiens

Mitogen-activated protein kinase 11
type: ProteinReference
xref: uniprot Q15759 345
xref: PTHR24055:SF109
organism: Homo sapiens

Map2k3 protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot B1H230 12
organism: Rattus norvegicus

uniprot Q9H1R2 275
type: UnificationXref
id: Q9H1R2
db: uniprot

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot P23583 77
xref: PTHR45851:SF1
organism: Pan troglodytes

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot A6QLS1 153
organism: Bos taurus

Dual specificity protein phosphatase 2
type: ProteinReference
xref: uniprot Q05922 216
organism: Mus musculus

Dual specificity protein phosphatase 18
type: ProteinReference
xref: uniprot Q8NEJ0 256
organism: Homo sapiens

Dual specificity protein phosphatase 2
type: ProteinReference
xref: uniprot Q05923 217
organism: Homo sapiens

ETS domain-containing protein Elk-1
type: ProteinReference
xref: uniprot P41969 360
xref: PTHR11849:SF178
organism: Mus musculus

uniprot Q9DGD9 135
type: UnificationXref
id: Q9DGD9
db: uniprot

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: uniprot Q4G050 368
xref: PTHR24349:SF114
organism: Rattus norvegicus

uniprot F6TJU6 363
type: UnificationXref
id: F6TJU6
db: uniprot

uniprot Q9BUB5 373
type: UnificationXref
id: Q9BUB5
db: uniprot

TRX
type: Protein
entity reference: TRX
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MKK4
type: Protein
entity reference: MKK4
feature: MKK4 s24 a31 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot H2QVZ4 197
organism: Pan troglodytes

JNK1/2
type: Protein
entity reference: JNK1/2
feature: ACTIVE 32
feature: JNK1 2 s23 a4 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 7165 59
type: UnificationXref
id: 7165
db: ncbitaxon

Stress-activated protein kinase jnk-1
type: ProteinReference
xref: PTHR24055:SF341
xref: uniprot Q8WQG9 133
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r6 432
type: Stoichiometry
physical entity: Complex (TRX/ASK-1)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 434
type: Stoichiometry
physical entity: ASK-1
stoichiometric coefficient: 1.0

uniprot F1PAY8 103
type: UnificationXref
id: F1PAY8
db: uniprot

PARTICIPANT STOICHIOMETRY r6 433
type: Stoichiometry
physical entity: TRX
stoichiometric coefficient: 1.0

Dual specificity protein phosphatase 14
type: ProteinReference
xref: uniprot Q9JLY7 278
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot A0A3Q2TY19 117
organism: Gallus gallus

uniprot F7B5L8 125
type: UnificationXref
id: F7B5L8
db: uniprot

p38
type: Protein
entity reference: p38
feature: ACTIVE 32
feature: p38 s28 a35 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot O15264 338
organism: Homo sapiens

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot A0A3Q1MNG1 8
organism: Bos taurus

Dual specificity phosphatase 28
type: ProteinReference
xref: uniprot Q8BTR5 254
organism: Mus musculus

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q95NE7 351
xref: PTHR24055:SF110
organism: Pan troglodytes

uniprot D4A3W6 160
type: UnificationXref
id: D4A3W6
db: uniprot

uniprot A1EC97 151
type: UnificationXref
id: A1EC97
db: uniprot

JNK1/2
type: Protein
entity reference: JNK1/2
feature: ACTIVE 32
feature: JNK1 2 s65 a45 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__ATP-_Myc-_Max-RIGHT__Complex__Max_Myc_-_ADP-_r29
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 455
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 456
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 457
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 454
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 453
left: Myc
left: Max
left: ATP
interaction type: HETERODIMER_ASSOCIATION
right: ADP
right: Complex (Max/Myc)

Stat1 s58 a82 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F6YR54 174
type: UnificationXref
id: F6YR54
db: uniprot

Dual specificity protein phosphatase 3
type: ProteinReference
xref: uniprot Q9D7X3 270
organism: Mus musculus

MAP kinase-interacting serine/threonine-protein kinase 2
type: ProteinReference
xref: uniprot Q9HBH9 376
xref: PTHR24349:SF254
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RIU2 97
xref: PTHR11945:SF145
organism: Macaca mulatta

uniprot Q9QYJ7 281
type: UnificationXref
id: Q9QYJ7
db: uniprot

uniprot M0R3K8 205
type: UnificationXref
id: M0R3K8
db: uniprot

Oxidative stress response
type: Pathway
pathway component: STATE_TRANSITION_LEFT__ATP-_p38-RIGHT__ADP-_p38-_r10
pathway component: PHYSICAL_STIMULATION
pathway component: STATE_TRANSITION_LEFT__Bcl_2-_ATP-RIGHT__ADP-_Bcl_2-_r43
pathway component: DISSOCIATION_LEFT__Complex__TRX_ASK_1_-RIGHT__TRX-_ASK_1-_r6
pathway component: STATE_TRANSITION_LEFT__ATP-_JNK1_2-RIGHT__JNK1_2-_ADP-_r7
pathway component: STATE_TRANSITION_LEFT__ATP-_MEF_2-RIGHT__ADP-_MEF_2-_r36
pathway component: STATE_TRANSITION_LEFT__MKK4-_ATP-RIGHT__MKK4-_ADP-_r8
pathway component: STATE_TRANSITION_LEFT__MNK1_2-_ATP-RIGHT__MNK1_2-_ADP-_r13
pathway component: STATE_TRANSITION_LEFT__ATP-_ATF_2-RIGHT__ATF_2-_ADP-_r24
pathway component: HETERODIMER_ASSOCIATION_LEFT__ATP-_Myc-_Max-RIGHT__Complex__Max_Myc_-_ADP-_r29
pathway component: STATE_TRANSITION_LEFT__eEF2K-RIGHT__eEF2K-_re37
pathway component: TRANSPORT_LEFT__p38-RIGHT__p38-_r44
pathway component: STATE_TRANSITION_LEFT__ATP-_Elk_1-RIGHT__Elk_1-_ADP-_r22
pathway component: STATE_TRANSITION_LEFT__ATP-_CHOP-RIGHT__CHOP-_ADP-_r34
pathway component: TRANSPORT_LEFT__JNK1_2-RIGHT__JNK1_2-_r45
pathway component: STATE_TRANSITION_LEFT__ATP-_c_jun-RIGHT__c_jun-_ADP-_r1
pathway component: STATE_TRANSITION_LEFT__cPLA2-_ATP-RIGHT__cPLA2-_ADP-_r15
pathway component: TRANSCRIPTION_LEFT__genes-RIGHT__genes-_re34
pathway component: STATE_TRANSITION_LEFT__ATP-_Stat1-RIGHT__ADP-_Stat1-_r31
pathway component: STATE_TRANSITION_LEFT__MKK3_6-_ATP-RIGHT__MKK3_6-_ADP-_r9
xref: PANTHER Pathway P00046 1
comment: MODEL_NOTES=Panther Pathway: P00046 Oxidative stress is a pathogenic condition that causes cellular damage. In a normal functioning cell, several transcription factors respond to this threat by modulating expression of genes whose products relieve the altered redox status. This pathway illustrates some of the intracellular signalling response regulating such gene expression. Medline=10207617 Medline=10487205 Medline=10557107 Medline=11274345 Medline=12115731 Website=www.cellsignal.com (copyright 2002 Cell Signalling Technology, Inc.) PMID: 10207617 PMID: 10487205 PMID: 10557107 PMID: 11274345 PMID: 12115731

uniprot D4A3U7 328
type: UnificationXref
id: D4A3U7
db: uniprot

PARTICIPANT STOICHIOMETRY r9 417
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

GEO12009p1
type: ProteinReference
xref: uniprot Q9VUG9 64
xref: PTHR45663:SF11
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r9 416
type: Stoichiometry
physical entity: MKK3/6
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MNK1_2-_ATP-RIGHT__MNK1_2-_ADP-_r13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 438
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 437
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 436
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 435
left: MNK1/2
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: MNK1/2

uniprot A6H7A7 152
type: UnificationXref
id: A6H7A7
db: uniprot

uniprot Q8WQG9 133
type: UnificationXref
id: Q8WQG9
db: uniprot

AGAP008228-PA
type: ProteinReference
xref: uniprot Q7PNB0 249
organism: Anopheles gambiae

PARTICIPANT STOICHIOMETRY r7 426
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F7B5L8 125
organism: Ornithorhynchus anatinus

uniprot F7GXT5 187
type: UnificationXref
id: F7GXT5
db: uniprot

PARTICIPANT STOICHIOMETRY r7 428
type: Stoichiometry
physical entity: JNK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 427
type: Stoichiometry
physical entity: JNK1/2
stoichiometric coefficient: 1.0

uniprot P08629 41
type: UnificationXref
id: P08629
db: uniprot

DUSP26 isoform 1
type: ProteinReference
xref: uniprot A0A2J8N820 147
organism: Pan troglodytes

Thioredoxin II
type: ProteinReference
xref: uniprot F5HBN4 33
organism: Neurospora crassa

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot F1MI99 167
organism: Bos taurus

IP21249p
type: ProteinReference
xref: uniprot Q9VAB0 285
organism: Drosophila melanogaster

uniprot F7B750 176
type: UnificationXref
id: F7B750
db: uniprot

STATE_TRANSITION_LEFT__ATP-_p38-RIGHT__ADP-_p38-_r10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 445
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 448
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 447
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 446
left: p38
left: ATP
interaction type: STATE_TRANSITION
right: p38
right: ADP

genes
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Dual specificity protein phosphatase 7
type: ProteinReference
xref: uniprot Q91Z46 260
organism: Mus musculus

uniprot F7FK48 108
type: UnificationXref
id: F7FK48
db: uniprot

uniprot A0A2I3S0F9 98
type: UnificationXref
id: A0A2I3S0F9
db: uniprot

MEF2C isoform 4
type: ProteinReference
xref: uniprot A0A2I3TMM0 99
xref: PTHR11945:SF145
organism: Pan troglodytes

ncbitaxon 36329 57
type: UnificationXref
id: 36329
db: ncbitaxon

MODULATION
type: RelationshipTypeVocabulary

Dual specificity protein phosphatase Mpk3
type: ProteinReference
xref: uniprot Q9VVW5 287
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
evidence: Evidence 364
xref: uniprot F6TJU6 363
xref: PTHR24349:SF114
organism: Macaca mulatta

c-jun
type: Protein
entity reference: c-jun
feature: ACTIVE 32
feature: c jun s7 a7 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 5

00696
type: UnificationXref
id: MOD:00696
db: mod

uniprot D3ZC16 158
type: UnificationXref
id: D3ZC16
db: uniprot

MKP5 s33 a41 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot H2R0P6 198
type: UnificationXref
id: H2R0P6
db: uniprot

uniprot Q8WTR2 258
type: UnificationXref
id: Q8WTR2
db: uniprot

Mitogen-activated protein kinase kinase 4A
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot B1NA68 380
organism: Danio rerio

Myocyte enhancer factor 2C
type: ProteinReference
xref: uniprot F1PAY8 103
xref: PTHR11945:SF25
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r9 414
type: Stoichiometry
physical entity: MKK3/6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 415
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Dual specificity protein phosphatase 21
type: ProteinReference
xref: uniprot Q9H596 276
organism: Homo sapiens

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A1D5R9X3 85
xref: PTHR11801:SF18
organism: Macaca mulatta

GO GO:0005634 2
type: UnificationXref
id: GO:0005634
db: GO

Dual specificity protein phosphatase 18
type: ProteinReference
xref: uniprot F7G1T6 184
organism: Macaca mulatta

Transcription factor AP-1
type: ProteinReference
xref: uniprot P05627 298
xref: PTHR11462:SF8
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R1Y7 96
xref: PTHR11945:SF637
organism: Macaca mulatta

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__genes-RIGHT__genes-_re34
control type: ACTIVATION
controller: ATF-2

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot Q9DGD9 135
organism: Danio rerio

uniprot E2R4V2 162
type: UnificationXref
id: E2R4V2
db: uniprot

ATP
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Dual specificity protein phosphatase 4
type: ProteinReference
xref: uniprot Q62767 240
organism: Rattus norvegicus

Bcl-2
type: Protein
entity reference: Bcl-2
feature: ACTIVE 32
feature: Bcl 2 s67 a97 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

DISSOCIATION
type: RelationshipTypeVocabulary

PTHR16833:SF0
type: RelationshipXref
id: PTHR16833:SF0
db: PANTHER Family
relationship type: By Homology

PTHR45663:SF11
type: RelationshipXref
id: PTHR45663:SF11
db: PANTHER Family
relationship type: By Homology

ncbitaxon 7668 84
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot P47713 321
type: UnificationXref
id: P47713
db: uniprot

uniprot Q13202 221
type: UnificationXref
id: Q13202
db: uniprot

Mitogen-activated protein kinase 14B
type: ProteinReference
xref: uniprot Q9DGE1 352
xref: PTHR24055:SF110
organism: Danio rerio

Mitogen-activated protein kinase 14A
type: ProteinReference
xref: uniprot Q9DGE2 353
xref: PTHR24055:SF110
organism: Danio rerio

MEF-2
type: ProteinReference
xref: P01128
standard name: myocyte enhancer factor-2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.MEF-2
comment: ENTITY_REFERENCE_NOTES= Long Name: myocyte enhancer factor-2 Synonym: ADCAD1,MADS box transcription enhancer factor 2,MEF2A,MEF2B,MEF2C,MEF2D Accession: P01128
member entity reference: Myocyte-specific enhancer factor 2C
member entity reference: Uncharacterized protein
member entity reference: Myocyte-specific enhancer factor 2A
member entity reference: Protein CBR-MEF-2
member entity reference: Myocyte enhancer factor 2C
member entity reference: MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)
member entity reference: Myocyte enhancer factor 2A
member entity reference: MEF2C isoform 4
member entity reference: Related to vertebrate MEF2 transcription factor
member entity reference: Myocyte enhancer factor 2ca

uniprot P46734 26
type: UnificationXref
id: P46734
db: uniprot

Dual specificity protein phosphatase 12
type: ProteinReference
xref: uniprot Q9UNI6 284
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6YAB9 333
xref: PTHR24055:SF110
organism: Monodelphis domestica

uniprot O02812 336
type: UnificationXref
id: O02812
db: uniprot

uniprot Q5VNG7 235
type: UnificationXref
id: Q5VNG7
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot H2QS62 126
organism: Pan troglodytes

ASK-1
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa2 391
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Thioredoxin
type: ProteinReference
xref: uniprot P29429 49
organism: Emericella nidulans

uniprot Q9U325 114
type: UnificationXref
id: Q9U325
db: uniprot

uniprot Q9VHV8 286
type: UnificationXref
id: Q9VHV8
db: uniprot

ncbitaxon 6239 61
type: UnificationXref
id: 6239
db: ncbitaxon

MYC associated factor X
type: ProteinReference
xref: uniprot A0A3Q1MV00 302
xref: PTHR10328:SF3
organism: Bos taurus

uniprot P10639 44
type: UnificationXref
id: P10639
db: uniprot

uniprot Q9NRW4 280
type: UnificationXref
id: Q9NRW4
db: uniprot

uniprot F1PXD3 16
type: UnificationXref
id: F1PXD3
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__genes-RIGHT__genes-_re34
control type: ACTIVATION
controller: c-jun

Dual specificity protein phosphatase 5
type: ProteinReference
xref: uniprot Q16690 222
organism: Homo sapiens

PTHR10438:SF18
type: RelationshipXref
id: PTHR10438:SF18
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_p38-RIGHT__ADP-_p38-_r10
controller: MKK4

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A4FV00 118
organism: Bos taurus

PTHR11945:SF637
type: RelationshipXref
id: PTHR11945:SF637
db: PANTHER Family
relationship type: By Homology

uniprot D3ZH31 159
type: UnificationXref
id: D3ZH31
db: uniprot

Elk-1
type: Protein
entity reference: Elk-1
feature: Elk 1 s38 a49 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Tyrosine-protein phosphatase YVH1
type: ProteinReference
xref: uniprot Q02256 215
organism: Saccharomyces cerevisiae

Dual specificity protein phosphatase 13 isoform B
type: ProteinReference
xref: uniprot Q9UII6 283
organism: Homo sapiens

STATE_TRANSITION
type: RelationshipTypeVocabulary

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__ATP-_JNK1_2-RIGHT__JNK1_2-_ADP-_r7
control type: INHIBITION
controller: MKP5

Eukaryotic elongation factor 2 kinase
type: ProteinReference
xref: PTHR45992:SF3
xref: uniprot P70531 95
organism: Rattus norvegicus

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot A0A2I3RB56 6
organism: Pan troglodytes

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: uniprot P46734 26
xref: PTHR48013:SF21
organism: Homo sapiens

Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
type: ProteinReference
xref: uniprot Q9TW67 60
organism: Caenorhabditis elegans

Signal transducer and activator of transcription 1-alpha/beta
type: ProteinReference
xref: PTHR11801:SF18
xref: uniprot P42224 87
organism: Homo sapiens

uniprot H2RGU9 200
type: UnificationXref
id: H2RGU9
db: uniprot

Dual specificity protein phosphatase 26
type: ProteinReference
xref: uniprot Q9BV47 265
organism: Homo sapiens

uniprot A0A2J8KW39 137
type: UnificationXref
id: A0A2J8KW39
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10159:SF299
xref: uniprot F1NXH3 169
organism: Gallus gallus

uniprot Q9BY84 266
type: UnificationXref
id: Q9BY84
db: uniprot

uniprot P92208 132
type: UnificationXref
id: P92208
db: uniprot

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2QS62 126
type: UnificationXref
id: H2QS62
db: uniprot

DUSP12 isoform 3
type: ProteinReference
xref: uniprot H2Q0H2 191
organism: Pan troglodytes

uniprot Q6P943 82
type: UnificationXref
id: Q6P943
db: uniprot

Dual specificity protein phosphatase 22
type: ProteinReference
xref: uniprot F7A8S7 175
organism: Macaca mulatta

PTHR11945:SF145
type: RelationshipXref
id: PTHR11945:SF145
db: PANTHER Family
relationship type: By Homology

Translation
type: Pathway

uniprot P52161 307
type: UnificationXref
id: P52161
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6ZTS0 334
xref: PTHR24055:SF146
organism: Macaca mulatta

DUSP19 protein
type: ProteinReference
xref: uniprot A6H7A7 152
organism: Bos taurus

Serine/threonine/tyrosine-interacting protein
type: ProteinReference
xref: uniprot D3ZH31 159
organism: Rattus norvegicus

uniprot F6PR50 382
type: UnificationXref
id: F6PR50
db: uniprot

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot F7EJU0 20
organism: Xenopus tropicalis

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cell Death
controller: genes

uniprot O62618 341
type: UnificationXref
id: O62618
db: uniprot

DNA damage-inducible transcript 3 protein
type: ProteinReference
xref: PTHR16833:SF0
xref: uniprot J9P1A6 139
organism: Canis lupus familiaris

uniprot A0A2I3TNY5 86
type: UnificationXref
id: A0A2I3TNY5
db: uniprot

uniprot F6RW93 171
type: UnificationXref
id: F6RW93
db: uniprot

uniprot F6XZU9 107
type: UnificationXref
id: F6XZU9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_CHOP-RIGHT__CHOP-_ADP-_r34
controller: p38

uniprot P49147 322
type: UnificationXref
id: P49147
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 102

STATE_TRANSITION_LEFT__eEF2K-RIGHT__eEF2K-_re37
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 400
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 401
left: eEF2K
interaction type: STATE_TRANSITION
right: eEF2K

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 61

Max s8 sa3 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Apoptosis regulator Bcl-2
type: ProteinReference
xref: PTHR11256:SF11
xref: uniprot P49950 69
organism: Rattus norvegicus

c jun s6 a6 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=1.52

Dual specificity protein phosphatase 14
type: ProteinReference
xref: uniprot F7GXT5 187
organism: Macaca mulatta

Dual specificity protein phosphatase 3
type: ProteinReference
xref: uniprot P51452 214
organism: Homo sapiens

Signal transducer and activator of transcription 1
type: ProteinReference
xref: PTHR11801:SF18
xref: uniprot P42225 78
organism: Mus musculus

uniprot Q16539 346
type: UnificationXref
id: Q16539
db: uniprot

uniprot F7HKX0 188
type: UnificationXref
id: F7HKX0
db: uniprot

PARTICIPANT STOICHIOMETRY r34 406
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot Q9BV47 265
type: UnificationXref
id: Q9BV47
db: uniprot

MKK3/6
type: ProteinReference
xref: P01121
standard name: Mitogen-activated protein kinase kinase 3 and 6
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.MKK3/6
comment: ENTITY_REFERENCE_NOTES= Long Name: Map Kinase Kinase 3 and Map Kinase Kinase 6 Synonym: MAPK/ERK KINASE 3,MAPK/ERK kinase 6,MAPKK3,MAPKK6,MEK3,MEK6,PRKMK3,PRKMK6,PROTEIN KINASE MITOGEN-ACTIVATED KINASE 3 Accession: P01121
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase kinase 3
member entity reference: Dual specificity mitogen-activated protein kinase kinase 3
member entity reference: Dual specificity mitogen-activated protein kinase kinase 6
member entity reference: Mitogen-activated protein kinase kinase 6
member entity reference: Map2k3 protein

eco ECO:0000304 25
type: UnificationXref
id: ECO:0000304
db: eco

MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)
type: ProteinReference
xref: uniprot F6WS85 106
xref: PTHR11945:SF25
organism: Xenopus tropicalis

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot O08911 337
organism: Mus musculus

Cell Death
type: Pathway

uniprot Q925D6 31
type: UnificationXref
id: Q925D6
db: uniprot

JNK1/2
type: ProteinReference
xref: P01129
standard name: c-jun N-terminal kinases 1 and 2
comment: ENTITY_REFERENCE_NOTES= Long Name: c-jun N-terminal kinases 1 and 2 Synonym: JNK1,JNK2,JNK55,MAPK8,MAPK9,SAPK1 Accession: P01129
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.JNK1/2
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Stress-activated protein kinase jnk-1
member entity reference: Stress-activated protein kinase JNK

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__genes-RIGHT__genes-_re34
control type: ACTIVATION
controller: CHOP

Dual specificity phosphatase 10
type: ProteinReference
xref: PTHR10159:SF299
xref: uniprot E2R7G4 163
organism: Canis lupus familiaris

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot D4A3U7 328
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r34 409
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r34 407
type: Stoichiometry
physical entity: CHOP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r34 408
type: Stoichiometry
physical entity: CHOP
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase p38b
type: ProteinReference
xref: uniprot O61443 340
xref: PTHR24055:SF238
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: uniprot Q75JM6 54
organism: Dictyostelium discoideum

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 312
xref: PTHR10728:SF13
xref: uniprot A4IFJ5 311
organism: Bos taurus

uniprot Q13115 220
type: UnificationXref
id: Q13115
db: uniprot

STATE_TRANSITION_LEFT__cPLA2-_ATP-RIGHT__cPLA2-_ADP-_r15
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 424
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 423
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 422
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 425
left: ATP
left: cPLA2
interaction type: STATE_TRANSITION
right: ADP
right: cPLA2

JNK1 2 s23 a4 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.63
comment: MODIFICATION_RESIDUE_NAME=

ncbitaxon 44689 55
type: UnificationXref
id: 44689
db: ncbitaxon

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot O09110 23
organism: Mus musculus

uniprot Q9WTY9 355
type: UnificationXref
id: Q9WTY9
db: uniprot

Dual specificity protein phosphatase 8
type: ProteinReference
xref: uniprot O09112 206
organism: Mus musculus

uniprot H2QS06 196
type: UnificationXref
id: H2QS06
db: uniprot

uniprot F1P630 120
type: UnificationXref
id: F1P630
db: uniprot

uniprot H2QVZ4 197
type: UnificationXref
id: H2QVZ4
db: uniprot

Thioredoxin-2
type: ProteinReference
xref: uniprot Q9V429 63
xref: PTHR10438:SF423
organism: Drosophila melanogaster

Dual-specificity phosphatase 14-like 1
type: ProteinReference
xref: uniprot M0R3K8 205
organism: Rattus norvegicus

MYC associated factor X
type: ProteinReference
xref: PTHR10328:SF3
xref: uniprot E2QZS2 303
organism: Canis lupus familiaris

uniprot F7CBU9 315
type: UnificationXref
id: F7CBU9
db: uniprot

uniprot Q17QM8 226
type: UnificationXref
id: Q17QM8
db: uniprot

Mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot F1PBB6 381
organism: Canis lupus familiaris

uniprot A0A2J8N820 147
type: UnificationXref
id: A0A2J8N820
db: uniprot

Dual specificity phosphatase 14
type: ProteinReference
xref: uniprot E2RB57 165
organism: Canis lupus familiaris

TRANSPORT
type: RelationshipTypeVocabulary

uniprot P10599 43
type: UnificationXref
id: P10599
db: uniprot

uniprot F6RHG3 35
type: UnificationXref
id: F6RHG3
db: uniprot

PTHR24055:SF222
type: RelationshipXref
id: PTHR24055:SF222
db: PANTHER Family
relationship type: By Homology

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P18870 300
organism: Gallus gallus

uniprot A0A1D5PXC6 115
type: UnificationXref
id: A0A1D5PXC6
db: uniprot

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 374

uniprot A0A2I3TJP1 88
type: UnificationXref
id: A0A2I3TJP1
db: uniprot

PARTICIPANT STOICHIOMETRY re37 401
type: Stoichiometry
physical entity: eEF2K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re37 400
type: Stoichiometry
physical entity: eEF2K
stoichiometric coefficient: 1.0

PTHR11801:SF18
type: RelationshipXref
id: PTHR11801:SF18
db: PANTHER Family
relationship type: By Homology

Apoptosis regulator Bcl-2
type: ProteinReference
xref: PTHR11256:SF11
xref: uniprot Q00709 70
organism: Gallus gallus

Dual specificity protein phosphatase 19
type: ProteinReference
xref: uniprot Q8K4T5 255
organism: Mus musculus

Thioredoxin
type: ProteinReference
xref: PTHR10438:SF18
xref: uniprot F6RHG3 35
organism: Macaca mulatta

uniprot Q8BTR5 254
type: UnificationXref
id: Q8BTR5
db: uniprot

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: PTHR24349:SF114
xref: uniprot O08605 366
organism: Mus musculus

uniprot D4A8F3 161
type: UnificationXref
id: D4A8F3
db: uniprot

uniprot H2QXP0 37
type: UnificationXref
id: H2QXP0
db: uniprot

uniprot J9P4K8 202
type: UnificationXref
id: J9P4K8
db: uniprot

Dual specificity protein phosphatase 12
type: ProteinReference
xref: uniprot Q9JIM4 277
organism: Rattus norvegicus

uniprot P35639 141
type: UnificationXref
id: P35639
db: uniprot

uniprot P10417 68
type: UnificationXref
id: P10417
db: uniprot

uniprot Q0IID7 218
type: UnificationXref
id: Q0IID7
db: uniprot

Dual specificity protein phosphatase 4
type: ProteinReference
xref: uniprot Q8BFV3 253
organism: Mus musculus

Dual specificity protein phosphatase 26
type: ProteinReference
xref: uniprot Q17QJ3 225
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR10159:SF299
xref: uniprot F7FRM2 183
organism: Macaca mulatta

DUSP22 isoform 3
type: ProteinReference
xref: uniprot A0A2I3RY19 145
organism: Pan troglodytes

Dual specificity phosphatase DUPD1
type: ProteinReference
xref: uniprot Q68J44 244
organism: Homo sapiens

Complex (TRX/ASK-1)
type: Complex
component stoichiometry: ASK 1 s3 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: TRX s1 sa1 STOICHIOMETRY ID COMPLEX
component: ASK-1
component: TRX
feature: COMPLEX BINDING FEATURE s22 a29 390
feature: COMPLEX BINDING FEATURE s22 a29 388
cellular location: cytosol

uniprot F1MEZ2 166
type: UnificationXref
id: F1MEZ2
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot P45985 386
xref: PTHR48013:SF20
organism: Homo sapiens

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 10

STATE_TRANSITION_LEFT__Bcl_2-_ATP-RIGHT__ADP-_Bcl_2-_r43
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 444
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 443
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 442
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 441
left: ATP
left: Bcl-2
interaction type: STATE_TRANSITION
right: Bcl-2
right: ADP

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot P45983 128
organism: Homo sapiens

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P45984 129
organism: Homo sapiens

uniprot J9P6D6 203
type: UnificationXref
id: J9P6D6
db: uniprot

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F1PXD3 16
organism: Canis lupus familiaris

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q9Z1B7 357
organism: Mus musculus

uniprot F7FXI4 109
type: UnificationXref
id: F7FXI4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PR50 382
xref: PTHR48016:SF32
organism: Macaca mulatta

uniprot F7BD74 19
type: UnificationXref
id: F7BD74
db: uniprot

Serine/threonine/tyrosine interacting protein
type: ProteinReference
xref: uniprot F7F2Q8 182
organism: Ornithorhynchus anatinus

Eukaryotic elongation factor 2 kinase
type: ProteinReference
xref: PTHR45992:SF3
xref: uniprot A0A2I3TJP1 88
organism: Pan troglodytes

uniprot Q9DGE2 353
type: UnificationXref
id: Q9DGE2
db: uniprot

uniprot F7DK42 179
type: UnificationXref
id: F7DK42
db: uniprot

Bcl 2 s68 a98 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MEF-2
type: Protein
entity reference: MEF-2
feature: MEF 2 s63 a91 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F6ZTS0 334
type: UnificationXref
id: F6ZTS0
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 18

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_c_jun-RIGHT__c_jun-_ADP-_r1
controller: JNK1/2

uniprot J9P1A6 139
type: UnificationXref
id: J9P1A6
db: uniprot

uniprot O09110 23
type: UnificationXref
id: O09110
db: uniprot

DNA damage-inducible transcript 3 protein
type: ProteinReference
xref: PTHR16833:SF0
xref: uniprot F6WA37 138
organism: Macaca mulatta

uniprot Q9WTU6 136
type: UnificationXref
id: Q9WTU6
db: uniprot

cPLA2 s31 a42 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A0A2I3RB56 6
type: UnificationXref
id: A0A2I3RB56
db: uniprot

uniprot Q5U2N4 370
type: UnificationXref
id: Q5U2N4
db: uniprot

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot F1MM08 168
organism: Bos taurus

ATF 2 s41 a50 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P70236 29
type: UnificationXref
id: P70236
db: uniprot

uniprot Q2HJ27 81
type: UnificationXref
id: Q2HJ27
db: uniprot

uniprot H2QLH7 195
type: UnificationXref
id: H2QLH7
db: uniprot

Myc
type: ProteinReference
xref: P01124
standard name: v-myc myelocytomatosis viral oncogene homolog
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: v-myc myelocytomatosis viral oncogene homolog Synonym: c-myc Accession: P01124
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.Myc
member entity reference: Myc proto-oncogene protein
member entity reference: Transcriptional regulator Myc-A
member entity reference: Signal transducer and activator of transcription 1
member entity reference: Uncharacterized protein
member entity reference: Signal transducer and activator of transcription

uniprot A0A3Q1MV00 302
type: UnificationXref
id: A0A3Q1MV00
db: uniprot

cPLA2 s50 a38 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__genes-RIGHT__genes-_re34
control type: ACTIVATION
controller: MEF-2

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6ZKB3 124
organism: Macaca mulatta

TRANSCRIPTION
type: InteractionVocabulary

uniprot O15264 338
type: UnificationXref
id: O15264
db: uniprot

c jun s7 a7 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=1.52

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EZU7 181
organism: Macaca mulatta

Dual specificity protein phosphatase 26
type: ProteinReference
xref: uniprot Q5FVI9 233
organism: Rattus norvegicus

Apoptosis regulator Bcl-2
type: ProteinReference
xref: PTHR11256:SF11
xref: uniprot O02718 66
organism: Bos taurus

Phospholipase A2
type: ProteinReference
evidence: Evidence 312
xref: uniprot F7EEZ1 316
xref: PTHR10728:SF13
organism: Macaca mulatta

uniprot P0C594 211
type: UnificationXref
id: P0C594
db: uniprot

MKK4
type: Protein
entity reference: MKK4
feature: MKK4 s25 a32 rs1
feature: ACTIVE 32
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MAP kinase phosphatase-1
type: ProteinReference
xref: uniprot Q9NGL1 279
organism: Drosophila melanogaster

Dual-specificity phosphatase 21
type: ProteinReference
xref: uniprot D3ZAQ8 156
organism: Rattus norvegicus

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 320
xref: PTHR10728:SF13
xref: uniprot P50393 324
organism: Rattus norvegicus

Cytosolic phospholipase A2
type: ProteinReference
xref: uniprot P50392 323
xref: PTHR10728:SF13
organism: Danio rerio

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot Q1HL35 228
organism: Mus musculus

PTHR10728:SF13
type: RelationshipXref
id: PTHR10728:SF13
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F6WV79 122
organism: Monodelphis domestica

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot O08648 385
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RHD1 4
organism: Macaca mulatta

uniprot Q19388 227
type: UnificationXref
id: Q19388
db: uniprot

eco ECO:0000245 374
type: UnificationXref
id: ECO:0000245
db: eco

uniprot Q7PV94 250
type: UnificationXref
id: Q7PV94
db: uniprot

uniprot P05412 297
type: UnificationXref
id: P05412
db: uniprot

Max s54 a75 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Bcl_2-_ATP-RIGHT__ADP-_Bcl_2-_r43
controller: JNK1/2

ncbitaxon 9913 9
type: UnificationXref
id: 9913
db: ncbitaxon

Dual specificity phosphatase 7
type: ProteinReference
xref: uniprot F7GK32 186
organism: Macaca mulatta

Elk-1
type: Protein
entity reference: Elk-1
feature: Elk 1 s40 a48 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

p38 s28 a35 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.63
comment: MODIFICATION_RESIDUE_NAME=

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A8WRD7 327
xref: PTHR24055:SF238
organism: Caenorhabditis briggsae

STATE_TRANSITION_LEFT__ATP-_ATF_2-RIGHT__ATF_2-_ADP-_r24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 461
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 458
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 460
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 459
left: ATF-2
left: ATP
interaction type: STATE_TRANSITION
right: ATF-2
right: ADP

Dual-specificity phosphatase 13
type: ProteinReference
xref: uniprot A0A0G2K9N1 144
organism: Rattus norvegicus

uniprot Q16690 222
type: UnificationXref
id: Q16690
db: uniprot

uniprot Q06413 110
type: UnificationXref
id: Q06413
db: uniprot

uniprot E2QZS2 303
type: UnificationXref
id: E2QZS2
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P47811 342
xref: PTHR24055:SF110
organism: Mus musculus

uniprot Q9JLY7 278
type: UnificationXref
id: Q9JLY7
db: uniprot

PARTICIPANT STOICHIOMETRY r22 399
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 398
type: Stoichiometry
physical entity: Elk-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 397
type: Stoichiometry
physical entity: Elk-1
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot Q5E9X2 30
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r22 396
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

MKK3/6
type: Protein
entity reference: MKK3/6
feature: ACTIVE 32
feature: MKK3 6 s27 a34 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q05922 216
type: UnificationXref
id: Q05922
db: uniprot

PARTICIPANT STOICHIOMETRY r7 429
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q4G050 368
type: UnificationXref
id: Q4G050
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 248

PTHR10728:SF32
type: RelationshipXref
id: PTHR10728:SF32
db: PANTHER Family
relationship type: By Homology

uniprot Q9D0T2 268
type: UnificationXref
id: Q9D0T2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK3_6-_ATP-RIGHT__MKK3_6-_ADP-_r9
controller: ASK-1

uniprot Q62857 143
type: UnificationXref
id: Q62857
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot P47809 387
xref: PTHR48013:SF15
organism: Mus musculus

uniprot Q5Z8E0 238
type: UnificationXref
id: Q5Z8E0
db: uniprot

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot F7HKX0 188
organism: Macaca mulatta

Phospholipase A2
type: ProteinReference
xref: PTHR10728:SF13
xref: uniprot F6QDY0 313
organism: Ornithorhynchus anatinus

uniprot F6VD47 104
type: UnificationXref
id: F6VD47
db: uniprot

PTHR24055:SF238
type: RelationshipXref
id: PTHR24055:SF238
db: PANTHER Family
relationship type: By Homology

uniprot O08605 366
type: UnificationXref
id: O08605
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 80

uniprot O08796 94
type: UnificationXref
id: O08796
db: uniprot

B-cell CLL/lymphoma 2
type: ProteinReference
xref: PTHR11256:SF11
xref: uniprot H2QEM8 65
organism: Pan troglodytes

uniprot P47809 387
type: UnificationXref
id: P47809
db: uniprot

Myocyte enhancer factor 2A
type: ProteinReference
xref: uniprot F6VD47 104
xref: PTHR11945:SF637
organism: Ornithorhynchus anatinus

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot Q63538 349
xref: PTHR24055:SF146
organism: Rattus norvegicus

Myocyte-specific enhancer factor 2A
type: ProteinReference
xref: PTHR48019:SF47
xref: uniprot A2VDZ3 100
organism: Bos taurus

ncbitaxon 6238 102
type: UnificationXref
id: 6238
db: ncbitaxon

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__ATP-_p38-RIGHT__ADP-_p38-_r10
control type: INHIBITION
controller: MKP5

uniprot Q64623 243
type: UnificationXref
id: Q64623
db: uniprot

TRX s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TRX
stoichiometric coefficient: 1.0

ncbitaxon 9606 27
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot Q28E94 229
type: UnificationXref
id: Q28E94
db: uniprot

uniprot A0A3Q2U428 149
type: UnificationXref
id: A0A3Q2U428
db: uniprot

uniprot P45983 128
type: UnificationXref
id: P45983
db: uniprot

Dual specificity protein phosphatase 26
type: ProteinReference
xref: uniprot Q9D700 269
organism: Mus musculus

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot P53778 343
organism: Homo sapiens

uniprot Q7TNL7 252
type: UnificationXref
id: Q7TNL7
db: uniprot

ATF 2 s43 a51 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__cPLA2-_ATP-RIGHT__cPLA2-_ADP-_r15
controller: MNK1/2

MKK3 6 s26 a33 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q9D9D8 271
type: UnificationXref
id: Q9D9D8
db: uniprot

Myocyte enhancer factor 2A
type: ProteinReference
xref: PTHR11945:SF637
xref: uniprot A0A2I3S0F9 98
organism: Pan troglodytes

Protein CBG00285
type: ProteinReference
xref: uniprot A8WML9 154
organism: Caenorhabditis briggsae

MAP kinase-interacting serine/threonine-protein kinase 2
type: ProteinReference
xref: uniprot Q5U2N4 370
xref: PTHR24349:SF254
organism: Rattus norvegicus

uniprot Q1HL35 228
type: UnificationXref
id: Q1HL35
db: uniprot

TRANSPORT_LEFT__p38-RIGHT__p38-_r44
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 439
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 440
left: p38
interaction type: TRANSPORT
right: p38

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot Q28E94 229
organism: Xenopus tropicalis

Thioredoxin
type: ProteinReference
xref: PTHR46115:SF1
xref: uniprot Q9NGZ1 58
organism: Anopheles gambiae

Bcl-2
type: Protein
entity reference: Bcl-2
feature: Bcl 2 s68 a98 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6YFQ2 173
type: UnificationXref
id: F6YFQ2
db: uniprot

Dual specificity protein phosphatase MPK-4
type: ProteinReference
xref: uniprot Q9VWF4 288
organism: Drosophila melanogaster

Dual specificity protein phosphatase 6
type: ProteinReference
xref: uniprot Q9DBB1 273
organism: Mus musculus

uniprot H2Q6K9 193
type: UnificationXref
id: H2Q6K9
db: uniprot

uniprot A8XFG0 101
type: UnificationXref
id: A8XFG0
db: uniprot

Stress-activated protein kinase JNK
type: ProteinReference
xref: PTHR24055:SF341
xref: uniprot P92208 132
organism: Drosophila melanogaster

p38 s34 a43 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.63
comment: MODIFICATION_RESIDUE_NAME=

uniprot P51452 214
type: UnificationXref
id: P51452
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot A0A3Q1LWJ8 116
organism: Bos taurus

Dual specificity phosphatase DUPD1
type: ProteinReference
xref: uniprot P0C594 211
organism: Pan troglodytes

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF18
xref: uniprot A0A2I3TNY5 86
organism: Pan troglodytes

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 13

Tyrosine-protein phosphatase vhp-1
type: ProteinReference
xref: uniprot Q10038 219
organism: Caenorhabditis elegans

uniprot Q75QN6 247
type: UnificationXref
id: Q75QN6
db: uniprot

uniprot F6V332 332
type: UnificationXref
id: F6V332
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

uniprot F1PW15 72
type: UnificationXref
id: F1PW15
db: uniprot

INHIBITION
type: RelationshipTypeVocabulary

MAP2K4 isoform 3
type: ProteinReference
xref: uniprot H2QCA7 384
xref: PTHR48013:SF20
organism: Pan troglodytes

uniprot P18870 300
type: UnificationXref
id: P18870
db: uniprot

CHOP
type: Protein
entity reference: CHOP
feature: CHOP s60 a86 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Elk 1 s38 a49 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q9UII6 283
type: UnificationXref
id: Q9UII6
db: uniprot

TRANSPORT_LEFT__JNK1_2-RIGHT__JNK1_2-_r45
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 430
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 431
left: JNK1/2
interaction type: TRANSPORT
right: JNK1/2

Dual specificity protein phosphatase 14
type: ProteinReference
xref: uniprot Q17QM8 226
organism: Bos taurus

uniprot P42225 78
type: UnificationXref
id: P42225
db: uniprot

STATE_TRANSITION_LEFT__MKK4-_ATP-RIGHT__MKK4-_ADP-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 418
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 421
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 420
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 419
left: ATP
left: MKK4
interaction type: STATE_TRANSITION
right: MKK4
right: ADP

uniprot Q9JIM4 277
type: UnificationXref
id: Q9JIM4
db: uniprot

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot F1PW15 72
xref: PTHR45851:SF1
organism: Canis lupus familiaris

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__genes-RIGHT__genes-_re34
control type: ACTIVATION
controller: Stat1

uniprot Q58D94 369
type: UnificationXref
id: Q58D94
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__genes-RIGHT__genes-_re34
control type: ACTIVATION
controller: Complex (Max/Myc)

Dual specificity protein phosphatase 22
type: ProteinReference
xref: uniprot Q9NRW4 280
organism: Homo sapiens

uniprot Q9H596 276
type: UnificationXref
id: Q9H596
db: uniprot

Dual specificity protein phosphatase 6
type: ProteinReference
xref: uniprot Q64346 242
organism: Rattus norvegicus

ncbitaxon 284812 39
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot B1NA68 380
type: UnificationXref
id: B1NA68
db: uniprot

PTHR24349:SF254
type: RelationshipXref
id: PTHR24349:SF254
db: PANTHER Family
relationship type: By Homology

uniprot F1MM08 168
type: UnificationXref
id: F1MM08
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DK42 179
organism: Monodelphis domestica

Thioredoxin
type: ProteinReference
xref: PTHR10438:SF18
xref: uniprot P10599 43
organism: Homo sapiens

uniprot Q6P902 53
type: UnificationXref
id: Q6P902
db: uniprot

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot A0A3Q1M4S8 148
organism: Bos taurus

uniprot F7DFP1 178
type: UnificationXref
id: F7DFP1
db: uniprot

uniprot H2R3E8 199
type: UnificationXref
id: H2R3E8
db: uniprot

PTHR48016:SF32
type: RelationshipXref
id: PTHR48016:SF32
db: PANTHER Family
relationship type: By Homology

PTHR11945:SF25
type: RelationshipXref
id: PTHR11945:SF25
db: PANTHER Family
relationship type: By Homology

uniprot F7HAF3 317
type: UnificationXref
id: F7HAF3
db: uniprot

Inactive dual specificity phosphatase 27
type: ProteinReference
xref: uniprot Q5VZP5 237
organism: Homo sapiens

ACTIVE 32
type: EntityFeature
comment: Active state

uniprot A0A2I3TE39 146
type: UnificationXref
id: A0A2I3TE39
db: uniprot

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot E2R7W7 14
organism: Canis lupus familiaris

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A3Q1M4S8 148
type: UnificationXref
id: A0A3Q1M4S8
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P17325 299
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HLA9 189
organism: Macaca mulatta

uniprot O77334 209
type: UnificationXref
id: O77334
db: uniprot

MODULATION
type: Control
xref: MODULATION
controller: p38

Bcl-2
type: ProteinReference
xref: P01123
standard name: b-cell lymphoma protein-2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: b-cell lymphoma protein-2 Synonym: Synonym not specified Accession: P01123
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.Bcl-2
member entity reference: Apoptosis regulator Bcl-2
member entity reference: B-cell CLL/lymphoma 2

p38
type: Protein
entity reference: p38
feature: p38 s5 a5 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Dual specificity protein phosphatase 7
type: ProteinReference
xref: uniprot Q63340 241
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot Q91Y86 134
type: UnificationXref
id: Q91Y86
db: uniprot

Dual specificity protein phosphatase 15
type: ProteinReference
xref: uniprot Q9H1R2 275
organism: Homo sapiens

uniprot P50392 323
type: UnificationXref
id: P50392
db: uniprot

uniprot Q91Z46 260
type: UnificationXref
id: Q91Z46
db: uniprot

uniprot F6WV79 122
type: UnificationXref
id: F6WV79
db: uniprot

Related to vertebrate MEF2 transcription factor
type: ProteinReference
xref: PTHR11945:SF534
xref: uniprot Q9U325 114
organism: Caenorhabditis elegans

uniprot H2Q0H2 191
type: UnificationXref
id: H2Q0H2
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__genes-RIGHT__genes-_re34
control type: ACTIVATION
controller: Elk-1

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 50

DUSP16 isoform 2
type: ProteinReference
xref: uniprot H2Q5H0 192
organism: Pan troglodytes

ncbitaxon 7955 80
type: UnificationXref
id: 7955
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F7GLY8 22
organism: Macaca mulatta

uniprot Q63340 241
type: UnificationXref
id: Q63340
db: uniprot

uniprot W4XIE2 83
type: UnificationXref
id: W4XIE2
db: uniprot

PARTICIPANT STOICHIOMETRY r44 440
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

uniprot Q2YDV1 232
type: UnificationXref
id: Q2YDV1
db: uniprot

uniprot Q5M863 234
type: UnificationXref
id: Q5M863
db: uniprot

Max
type: ProteinReference
xref: P01133
standard name: myc-associated factor X
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.Max
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: myc-associated factor X Synonym: Synonym not specified Accession: P01133
member entity reference: Protein max
member entity reference: MYC associated factor X
member entity reference: Protein max isoform a

uniprot A8WML9 154
type: UnificationXref
id: A8WML9
db: uniprot

Thioredoxin
type: ProteinReference
xref: uniprot O97680 40
xref: PTHR10438:SF18
organism: Bos taurus

uniprot P47938 51
type: UnificationXref
id: P47938
db: uniprot

Apoptosis regulator Bcl-2
type: ProteinReference
xref: PTHR11256:SF11
xref: uniprot P10417 68
organism: Mus musculus

uniprot P53778 343
type: UnificationXref
id: P53778
db: uniprot

uniprot Q9DAR2 272
type: UnificationXref
id: Q9DAR2
db: uniprot

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot F7B750 176
organism: Ornithorhynchus anatinus

Apoptosis regulator Bcl-2
type: ProteinReference
xref: PTHR11256:SF11
xref: uniprot P10415 67
organism: Homo sapiens

Eukaryotic elongation factor 2 kinase
type: ProteinReference
xref: PTHR45992:SF3
xref: uniprot E1BEM1 89
organism: Bos taurus

Mitogen-activated protein kinase 11
type: ProteinReference
xref: uniprot Q9WUI1 356
xref: PTHR24055:SF109
organism: Mus musculus

uniprot F6TKL3 121
type: UnificationXref
id: F6TKL3
db: uniprot

uniprot F5HBN4 33
type: UnificationXref
id: F5HBN4
db: uniprot

uniprot P10415 67
type: UnificationXref
id: P10415
db: uniprot

uniprot Q2KJ36 230
type: UnificationXref
id: Q2KJ36
db: uniprot

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot H2Q6K9 193
organism: Pan troglodytes

Mitogen-activated protein kinase p38a
type: ProteinReference
xref: uniprot O62618 341
xref: PTHR24055:SF238
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r45 430
type: Stoichiometry
physical entity: JNK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 431
type: Stoichiometry
physical entity: JNK1/2
stoichiometric coefficient: 1.0

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 47

uniprot F7EZU7 181
type: UnificationXref
id: F7EZU7
db: uniprot

uniprot H2QCA7 384
type: UnificationXref
id: H2QCA7
db: uniprot

PARTICIPANT STOICHIOMETRY r8 421
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase pmk-1
type: ProteinReference
xref: uniprot Q17446 347
xref: PTHR24055:SF238
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r8 420
type: Stoichiometry
physical entity: MKK4
stoichiometric coefficient: 1.0

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 52

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_p38-RIGHT__ADP-_p38-_r10
controller: MKK3/6

Dual specificity phosphatase 19 (Predicted), isoform CRA_b
type: ProteinReference
xref: uniprot D4A8F3 161
organism: Rattus norvegicus

PTHR48019:SF47
type: RelationshipXref
id: PTHR48019:SF47
db: PANTHER Family
relationship type: By Homology

Stat1
type: Protein
entity reference: Stat1
feature: Stat1 s57 a81 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r8 418
type: Stoichiometry
physical entity: MKK4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 419
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: uniprot Q66JF3 371
organism: Xenopus tropicalis

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot Q7TNL7 252
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5PXC6 115
organism: Gallus gallus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A8X1S0 119
xref: PTHR24055:SF341
organism: Caenorhabditis briggsae

Thioredoxin domain-containing protein 2
type: ProteinReference
xref: uniprot Q6P902 53
organism: Mus musculus

uniprot Q7T2L8 251
type: UnificationXref
id: Q7T2L8
db: uniprot

uniprot A0A1D5RIU2 97
type: UnificationXref
id: A0A1D5RIU2
db: uniprot

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 57

uniprot Q9N272 354
type: UnificationXref
id: Q9N272
db: uniprot

ADP
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Dual specificity protein phosphatase 1
type: ProteinReference
xref: uniprot Q64623 243
organism: Rattus norvegicus

ncbitaxon 3702 248
type: UnificationXref
id: 3702
db: ncbitaxon

DNA damage-inducible transcript 3 protein
type: ProteinReference
xref: PTHR16833:SF0
xref: uniprot P35638 140
organism: Homo sapiens

DNA damage-inducible transcript 3 protein
type: ProteinReference
xref: PTHR16833:SF0
xref: uniprot P35639 141
organism: Mus musculus

uniprot P45984 129
type: UnificationXref
id: P45984
db: uniprot

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot K7CSV8 204
organism: Pan troglodytes

uniprot A0A0G2K9N1 144
type: UnificationXref
id: A0A0G2K9N1
db: uniprot

MAP kinase interacting serine/threonine kinase 2
type: ProteinReference
xref: PTHR24349:SF254
xref: uniprot E1BCH7 362
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r36 405
type: Stoichiometry
physical entity: MEF-2
stoichiometric coefficient: 1.0

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot Q6GLD5 245
organism: Xenopus tropicalis

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot J9P4K8 202
organism: Canis lupus familiaris

uniprot A0A1D5RHD1 4
type: UnificationXref
id: A0A1D5RHD1
db: uniprot

uniprot Q63538 349
type: UnificationXref
id: Q63538
db: uniprot

uniprot Q16828 223
type: UnificationXref
id: Q16828
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F1P630 120
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r36 402
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 21

PARTICIPANT STOICHIOMETRY r36 404
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r36 403
type: Stoichiometry
physical entity: MEF-2
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_MEF_2-RIGHT__ADP-_MEF_2-_r36
controller: p38

MEF 2 s62 a90 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q5E9X2 30
type: UnificationXref
id: Q5E9X2
db: uniprot

PTHR45851:SF1
type: RelationshipXref
id: PTHR45851:SF1
db: PANTHER Family
relationship type: By Homology

uniprot E2R7G4 163
type: UnificationXref
id: E2R7G4
db: uniprot

PARTICIPANT STOICHIOMETRY r10 445
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 446
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

uniprot E1BEM1 89
type: UnificationXref
id: E1BEM1
db: uniprot

PARTICIPANT STOICHIOMETRY r10 447
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 448
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

Thioredoxin
type: ProteinReference
xref: PTHR10438:SF18
xref: uniprot P11232 45
organism: Rattus norvegicus

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot F1MEZ2 166
organism: Bos taurus

uniprot Q00709 70
type: UnificationXref
id: Q00709
db: uniprot

uniprot Q66JF3 371
type: UnificationXref
id: Q66JF3
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot H2R0G7 127
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot Q95XK5 262
organism: Caenorhabditis elegans

Myocyte-specific enhancer factor 2C
type: ProteinReference
xref: uniprot Q8CFN5 113
xref: PTHR11945:SF25
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK4-_ATP-RIGHT__MKK4-_ADP-_r8
controller: ASK-1

STATE_TRANSITION_LEFT__ATP-_JNK1_2-RIGHT__JNK1_2-_ADP-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 429
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 427
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 428
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 426
left: JNK1/2
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: JNK1/2

MKK4 s25 a32 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F7H2R2 36
type: UnificationXref
id: F7H2R2
db: uniprot

uniprot Q9D7X3 270
type: UnificationXref
id: Q9D7X3
db: uniprot

uniprot Q9ZR37 292
type: UnificationXref
id: Q9ZR37
db: uniprot

STATE_TRANSITION_LEFT__ATP-_Elk_1-RIGHT__Elk_1-_ADP-_r22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 397
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 399
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 398
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 396
left: Elk-1
left: ATP
interaction type: STATE_TRANSITION
right: Elk-1
right: ADP

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot Q5M863 234
organism: Rattus norvegicus

uniprot Q9VAB0 285
type: UnificationXref
id: Q9VAB0
db: uniprot

Dual specificity protein phosphatase 10
type: ProteinReference
xref: uniprot Q9Y6W6 291
xref: PTHR10159:SF299
organism: Homo sapiens

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot Q925D6 31
organism: Rattus norvegicus

uniprot F7GLY8 22
type: UnificationXref
id: F7GLY8
db: uniprot

uniprot A8WRD7 327
type: UnificationXref
id: A8WRD7
db: uniprot

uniprot A0A0G2K3R1 377
type: UnificationXref
id: A0A0G2K3R1
db: uniprot

Thioredoxin-2
type: ProteinReference
xref: uniprot P22803 48
organism: Saccharomyces cerevisiae

uniprot P52564 28
type: UnificationXref
id: P52564
db: uniprot

uniprot P28563 213
type: UnificationXref
id: P28563
db: uniprot

Myocyte enhancer factor 2A
type: ProteinReference
xref: uniprot F6XZU9 107
xref: PTHR11945:SF637
organism: Canis lupus familiaris

uniprot F7GDU1 185
type: UnificationXref
id: F7GDU1
db: uniprot

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot A0A3Q2U428 149
organism: Gallus gallus

ncbitaxon 13616 18
type: UnificationXref
id: 13616
db: ncbitaxon

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P49186 130
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6TKL3 121
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__cPLA2-_ATP-RIGHT__cPLA2-_ADP-_r15
controller: p38

uniprot A0A3Q1LWJ8 116
type: UnificationXref
id: A0A3Q1LWJ8
db: uniprot

uniprot Q9NGZ1 58
type: UnificationXref
id: Q9NGZ1
db: uniprot

uniprot A0A3Q2TY19 117
type: UnificationXref
id: A0A3Q2TY19
db: uniprot

uniprot Q15759 345
type: UnificationXref
id: Q15759
db: uniprot

uniprot F7C798 335
type: UnificationXref
id: F7C798
db: uniprot

eEF2K
type: ProteinReference
xref: P01127
standard name: elongation factor 2 kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: elongation factor 2 kinase Synonym: Calmodulin-dependent protein kinase III Accession: P01127
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.eEF2K
member entity reference: Eukaryotic elongation factor 2 kinase

MKK3 6 s27 a34 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r44 439
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

Myc proto-oncogene protein
type: ProteinReference
xref: PTHR45851:SF1
xref: uniprot Q2HJ27 81
organism: Bos taurus

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot O77334 209
organism: Plasmodium falciparum

Thioredoxin
type: ProteinReference
xref: PTHR10438:SF18
xref: uniprot P10639 44
organism: Mus musculus

uniprot O02718 66
type: UnificationXref
id: O02718
db: uniprot

Dual specificity protein phosphatase 10
type: ProteinReference
xref: PTHR10159:SF299
xref: uniprot Q9ESS0 274
organism: Mus musculus

Phospholipase A2
type: ProteinReference
evidence: Evidence 312
xref: uniprot F6UQ33 314
xref: PTHR10728:SF13
organism: Canis lupus familiaris

Protein max isoform a
type: ProteinReference
xref: PTHR10328:SF3
xref: uniprot F6XM92 304
organism: Macaca mulatta

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot F7DFP1 178
organism: Monodelphis domestica

DUSP14 isoform 1
type: ProteinReference
xref: uniprot H2QCS1 194
organism: Pan troglodytes

Eukaryotic elongation factor 2 kinase
type: ProteinReference
xref: PTHR45992:SF3
xref: uniprot O01991 93
organism: Caenorhabditis elegans

ASK-1
type: Protein
feature: ACTIVE 32
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q8VE01 257
type: UnificationXref
id: Q8VE01
db: uniprot

uniprot Q05923 217
type: UnificationXref
id: Q05923
db: uniprot

MKP5
type: ProteinReference
xref: P01131
standard name: Mitogen activated protein kinase phosphatase 5
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.MKP5
comment: ENTITY_REFERENCE_NOTES= Long Name: MAP Kinase Phosphatases Synonym: HePTP,M3/6,MKP-1,MKP-2,MKP-4,MKP-5,MKP-6,PAC-1,PP2A,Wip1 Accession: P01131
member entity reference: Dual specificity protein phosphatase Mpk3
member entity reference: Dual specificity protein phosphatase 13 isoform B
member entity reference: Dual specificity protein phosphatase 6
member entity reference: Dual specificity protein phosphatase 3
member entity reference: Dual-specificity phosphatase 13
member entity reference: Dual specificity protein phosphatase
member entity reference: Uncharacterized protein
member entity reference: Protein CBG03773
member entity reference: Dual specificity protein phosphatase 5
member entity reference: Os01g0347000 protein
member entity reference: Dual specificity protein phosphatase 12
member entity reference: Serine/threonine/tyrosine-interacting protein
member entity reference: Dual specificity protein phosphatase 1
member entity reference: Dual specificity protein phosphatase 26
member entity reference: Dual specificity phosphatase 22 (Predicted), isoform CRA_a
member entity reference: Dual specificity phosphatase 10
member entity reference: Dual specificity protein phosphatase 19
member entity reference: Dual specificity protein phosphatase 8
member entity reference: Dual-specificity phosphatase 16
member entity reference: Dual specificity protein phosphatase 22
member entity reference: Dual specificity protein phosphatase 4
member entity reference: Dual-specificity protein phosphatase 18
member entity reference: Dual specificity protein phosphatase 16
member entity reference: Serine/threonine/tyrosine interacting protein
member entity reference: Dual specificity protein phosphatase 18
member entity reference: Dual specificity phosphatase DUPD1
member entity reference: DUSP19 protein
member entity reference: Tyrosine-protein phosphatase yvh1
member entity reference: AGAP008228-PA
member entity reference: Dual specificity phosphatase 10 (Predicted)
member entity reference: Dual specificity phosphatase 3
member entity reference: IP21249p
member entity reference: Dual specificity protein phosphatase 2
member entity reference: Dual specificity protein phosphatase 21
member entity reference: Dual specificity protein phosphatase 7
member entity reference: Dual specificity protein phosphatase 14
member entity reference: DUSP16 isoform 2
member entity reference: Dual specificity phosphatase 14
member entity reference: Serine/threonine/tyrosine interacting-like 1, isoform CRA_c

IDA
type: EvidenceCodeVocabulary

MNK1/2
type: Protein
entity reference: MNK1/2
feature: ACTIVE 32
feature: MNK1 2 s49 a40 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A8X1S0 119
type: UnificationXref
id: A8X1S0
db: uniprot

uniprot A0A1D5R1Y7 96
type: UnificationXref
id: A0A1D5R1Y7
db: uniprot

PARTICIPANT STOICHIOMETRY r1 452
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 450
type: Stoichiometry
physical entity: c-jun
stoichiometric coefficient: 1.0

uniprot Q99N11 264
type: UnificationXref
id: Q99N11
db: uniprot

PARTICIPANT STOICHIOMETRY r1 451
type: Stoichiometry
physical entity: c-jun
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cell Survival
controller: genes

PTHR48013:SF15
type: RelationshipXref
id: PTHR48013:SF15
db: PANTHER Family
relationship type: By Homology

Evidence 364
type: Evidence
evidence code: ISS
comment: SPACC Q9BUB5

Bos taurus
type: BioSource
xref: ncbitaxon 9913 9

MAP kinase-interacting serine/threonine-protein kinase 2
type: ProteinReference
xref: uniprot Q8CDB0 372
xref: PTHR24349:SF254
organism: Mus musculus

uniprot A4GTP4 358
type: UnificationXref
id: A4GTP4
db: uniprot

uniprot Q9VWF4 288
type: UnificationXref
id: Q9VWF4
db: uniprot

ncbitaxon 9598 7
type: UnificationXref
id: 9598
db: ncbitaxon

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 105

ncbitaxon 367110 34
type: UnificationXref
id: 367110
db: ncbitaxon

p38
type: ProteinReference
xref: P01135
standard name: p38 mitogen activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.p38
comment: ENTITY_REFERENCE_NOTES= Long Name: p38 MAP Kinase Synonym: CSBP1,EXIP,MAPK14,Mxi2,RK,SAPK2A Accession: P01135
member entity reference: Mitogen-activated protein kinase 12
member entity reference: Mitogen-activated protein kinase 14B
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase pmk-2
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase p38a
member entity reference: Mitogen-activated protein kinase p38b
member entity reference: Mitogen-activated protein kinase pmk-1
member entity reference: Mitogen-activated protein kinase 14A

PTHR48013:SF21
type: RelationshipXref
id: PTHR48013:SF21
db: PANTHER Family
relationship type: By Homology

Dual specificity protein phosphatase 19
type: ProteinReference
xref: uniprot Q8WTR2 258
organism: Homo sapiens

PTHR48013:SF20
type: RelationshipXref
id: PTHR48013:SF20
db: PANTHER Family
relationship type: By Homology

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot P70236 29
organism: Mus musculus

Dual specificity protein phosphatase 8
type: ProteinReference
xref: uniprot Q13202 221
organism: Homo sapiens

uniprot Q9ESS0 274
type: UnificationXref
id: Q9ESS0
db: uniprot

Elk-1
type: ProteinReference
xref: P01136
standard name: ELK-1 protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.Elk-1
comment: ENTITY_REFERENCE_NOTES= Long Name: ELK-1 protein Synonym: ELK1 member of ETS oncogene family Accession: P01136
member entity reference: ETS domain-containing protein Elk-1

JNK1/2
type: Protein
entity reference: JNK1/2
feature: JNK1 2 s4 a30 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot G3MYQ0 190
organism: Bos taurus

JNK1 2 s4 a30 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.63
comment: MODIFICATION_RESIDUE_NAME=

Protein-tyrosine-phosphatase MKP1
type: ProteinReference
xref: uniprot Q9C5S1 267
organism: Arabidopsis thaliana

Myc s9 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Myc
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r31 413
type: Stoichiometry
physical entity: Stat1
stoichiometric coefficient: 1.0

MKK4 s24 a31 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Dual specificity protein phosphatase PHS1
type: ProteinReference
xref: uniprot Q75QN6 247
organism: Arabidopsis thaliana

uniprot A6QLS1 153
type: UnificationXref
id: A6QLS1
db: uniprot

Thioredoxin-1
type: ProteinReference
xref: uniprot P47938 51
xref: PTHR10438:SF423
organism: Drosophila melanogaster

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot J9P6D6 203
organism: Canis lupus familiaris

Cytosolic phospholipase A2
type: ProteinReference
xref: uniprot P49147 322
xref: PTHR10728:SF13
organism: Gallus gallus

uniprot Q99956 263
type: UnificationXref
id: Q99956
db: uniprot

PARTICIPANT STOICHIOMETRY r31 411
type: Stoichiometry
physical entity: Stat1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r31 412
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r31 410
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

MAP2K4 protein
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot A5PJP8 379
organism: Bos taurus

uniprot H2Q5H0 192
type: UnificationXref
id: H2Q5H0
db: uniprot

uniprot Q6GLD5 245
type: UnificationXref
id: Q6GLD5
db: uniprot

uniprot P49186 130
type: UnificationXref
id: P49186
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot W4XIE2 83
organism: Strongylocentrotus purpuratus

Dual specificity protein phosphatase 3
type: ProteinReference
xref: uniprot F7C5I2 177
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r1 449
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot A2VDZ3 100
type: UnificationXref
id: A2VDZ3
db: uniprot

ncbitaxon 10090 24
type: UnificationXref
id: 10090
db: ncbitaxon

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 15

PARTICIPANT STOICHIOMETRY r24 460
type: Stoichiometry
physical entity: ATF-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 461
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

p38 s5 a5 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.63
comment: MODIFICATION_RESIDUE_NAME=

uniprot F6XM92 304
type: UnificationXref
id: F6XM92
db: uniprot

uniprot O00418 92
type: UnificationXref
id: O00418
db: uniprot

cPLA2
type: Protein
entity reference: cPLA2
feature: cPLA2 s31 a42 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot E2RB57 165
type: UnificationXref
id: E2RB57
db: uniprot

ncbitaxon 9615 15
type: UnificationXref
id: 9615
db: ncbitaxon

Dual specificity protein phosphatase 13 isoform B
type: ProteinReference
xref: uniprot Q9QYJ7 281
organism: Mus musculus

MNK1/2
type: Protein
entity reference: MNK1/2
feature: MNK1 2 s30 a37 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q17446 347
type: UnificationXref
id: Q17446
db: uniprot

uniprot Q9TW67 60
type: UnificationXref
id: Q9TW67
db: uniprot

Eukaryotic elongation factor 2 kinase
type: ProteinReference
xref: uniprot O00418 92
xref: PTHR45992:SF3
organism: Homo sapiens

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 42

Complex (Max/Myc)
type: Complex
component stoichiometry: Max s8 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: Myc s9 sa4 STOICHIOMETRY ID COMPLEX
component: Myc
component: Max
feature: COMPLEX BINDING FEATURE s56 a78 394
feature: COMPLEX BINDING FEATURE s56 a78 392
cellular location: nucleus

uniprot O95147 210
type: UnificationXref
id: O95147
db: uniprot

Dual specificity protein phosphatase 16
type: ProteinReference
xref: uniprot Q9BY84 266
organism: Homo sapiens

Serine/threonine/tyrosine interacting-like 1, isoform CRA_c
type: ProteinReference
xref: uniprot Q9DAR2 272
organism: Mus musculus

PTHR11256:SF11
type: RelationshipXref
id: PTHR11256:SF11
db: PANTHER Family
relationship type: By Homology

PTHR11945:SF534
type: RelationshipXref
id: PTHR11945:SF534
db: PANTHER Family
relationship type: By Homology

Protein max
type: ProteinReference
xref: PTHR10328:SF3
xref: uniprot P28574 306
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r24 459
type: Stoichiometry
physical entity: ATF-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 458
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PTHR10328:SF3
type: RelationshipXref
id: PTHR10328:SF3
db: PANTHER Family
relationship type: By Homology

Thioredoxin-1
type: ProteinReference
xref: uniprot O14463 38
organism: Schizosaccharomyces pombe

uniprot H2RH74 201
type: UnificationXref
id: H2RH74
db: uniprot

uniprot Q9XXK8 290
type: UnificationXref
id: Q9XXK8
db: uniprot

genes
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

Dual specificity phosphatase 3
type: ProteinReference
xref: uniprot Q2T9T7 231
organism: Bos taurus

ncbitaxon 559292 47
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot E2RSB0 330
type: UnificationXref
id: E2RSB0
db: uniprot

uniprot Q02256 215
type: UnificationXref
id: Q02256
db: uniprot

uniprot O13632 207
type: UnificationXref
id: O13632
db: uniprot

uniprot F7DVA0 180
type: UnificationXref
id: F7DVA0
db: uniprot

Dual specificity phosphatase 16 (Predicted)
type: ProteinReference
xref: uniprot D4A3W6 160
organism: Rattus norvegicus

eEF2K
type: Protein
entity reference: eEF2K
feature: ACTIVE 32
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot O01991 93
type: UnificationXref
id: O01991
db: uniprot

uniprot P52160 79
type: UnificationXref
id: P52160
db: uniprot

c-jun
type: ProteinReference
xref: P01132
standard name: jun sarcoma virus 17 oncogene homolog
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.c-jun
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: jun sarcoma virus 17 oncogene homolog Synonym: Synonym not specified Accession: P01132
member entity reference: Transcription factor AP-1
member entity reference: Jun proto-oncogene, AP-1 transcription factor subunit
member entity reference: Jun proto-oncogene

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P70618 344
xref: PTHR24055:SF110
organism: Rattus norvegicus

uniprot Q0IIB6 142
type: UnificationXref
id: Q0IIB6
db: uniprot

uniprot G3MYQ0 190
type: UnificationXref
id: G3MYQ0
db: uniprot

uniprot F1NXH3 169
type: UnificationXref
id: F1NXH3
db: uniprot

MKP5
type: Protein
entity reference: MKP5
feature: MKP5 s33 a41 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot Q19388 227
organism: Caenorhabditis elegans

uniprot F6RYL1 295
type: UnificationXref
id: F6RYL1
db: uniprot

uniprot Q95XK5 262
type: UnificationXref
id: Q95XK5
db: uniprot

Jun proto-oncogene
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot F6RYL1 295
organism: Xenopus tropicalis

STYX isoform 1
type: ProteinReference
xref: uniprot H2R0P6 198
organism: Pan troglodytes

CHOP
type: Protein
entity reference: CHOP
feature: CHOP s61 a87 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Dual-specificity protein phosphatase 18
type: ProteinReference
xref: uniprot A0A452DIT1 150
organism: Bos taurus

uniprot F7EJU0 20
type: UnificationXref
id: F7EJU0
db: uniprot

uniprot F7GK32 186
type: UnificationXref
id: F7GK32
db: uniprot

uniprot P01106 73
type: UnificationXref
id: P01106
db: uniprot

uniprot F1MI99 167
type: UnificationXref
id: F1MI99
db: uniprot

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 320
xref: uniprot P47712 319
xref: PTHR10728:SF13
organism: Homo sapiens

Thioredoxin
type: ProteinReference
xref: PTHR10438:SF18
xref: uniprot H2QXP0 37
organism: Pan troglodytes

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 312
xref: uniprot P47713 321
xref: PTHR10728:SF13
organism: Mus musculus

uniprot Q8WUJ0 259
type: UnificationXref
id: Q8WUJ0
db: uniprot

uniprot Q8CFN5 113
type: UnificationXref
id: Q8CFN5
db: uniprot

Dual specificity protein phosphatase 1
type: ProteinReference
xref: uniprot P28563 213
organism: Mus musculus

Dual specificity protein phosphatase 1
type: ProteinReference
xref: uniprot P28562 212
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r43 442
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r43 441
type: Stoichiometry
physical entity: Bcl-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r43 444
type: Stoichiometry
physical entity: Bcl-2
stoichiometric coefficient: 1.0

Protein max
type: ProteinReference
xref: uniprot P61244 309
xref: PTHR10328:SF3
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r43 443
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot P70618 344
type: UnificationXref
id: P70618
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 236

MNK1/2
type: ProteinReference
xref: P01137
standard name: Mitogen-activated protein kinase-interacting serine/threonine kinase1/2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.MNK1/2
comment: ENTITY_REFERENCE_NOTES= Long Name: MAPK-interacting kinases 1/2 Synonym: GPRK7,MITOGEN-ACTIVATED PROTEIN KINASE-INTERACTING SERINE/THREONINE KINASE 1,MKNK1,MKNK2,MNK1,MNK2 Accession: P01137
member entity reference: MAP kinase-interacting serine/threonine-protein kinase 2
member entity reference: MAP kinase-interacting serine/threonine-protein kinase 1
member entity reference: MAP kinase-interacting serine/threonine-protein kinase 2 isoform 2
member entity reference: Uncharacterized protein
member entity reference: MAP kinase interacting serine/threonine kinase 2
member entity reference: MAP kinase-interacting serine/threonine kinase 2b

Evidence 375
type: Evidence
evidence code: RCA
comment: SPACC Q9BUB5

DNA damage-inducible transcript 3 protein
type: ProteinReference
xref: PTHR16833:SF0
xref: uniprot Q62857 143
organism: Rattus norvegicus

ATF-2
type: Protein
feature: ATF 2 s41 a50 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q9TY00 282
type: UnificationXref
id: Q9TY00
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF18
xref: uniprot Q6P943 82
organism: Danio rerio

uniprot Q9WUI1 356
type: UnificationXref
id: Q9WUI1
db: uniprot

uniprot Q9C5S1 267
type: UnificationXref
id: Q9C5S1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Elk_1-RIGHT__Elk_1-_ADP-_r22
controller: p38

Myc proto-oncogene protein
type: ProteinReference
xref: PTHR45851:SF1
xref: uniprot B8XIA5 71
organism: Macaca mulatta

uniprot Q9DGE1 352
type: UnificationXref
id: Q9DGE1
db: uniprot

MNK1 2 s30 a37 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Protein max
type: ProteinReference
xref: PTHR10328:SF3
xref: uniprot P52164 308
organism: Rattus norvegicus

Dual specificity protein phosphatase 18
type: ProteinReference
xref: uniprot Q8VE01 257
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Z879 383
xref: PTHR48013:SF15
organism: Monodelphis domestica

Protein max
type: ProteinReference
xref: PTHR10328:SF3
xref: uniprot P52161 307
organism: Danio rerio

Transcriptional regulator Myc-A
type: ProteinReference
xref: PTHR45851:SF1
xref: uniprot P52160 79
organism: Danio rerio

uniprot Q68J44 244
type: UnificationXref
id: Q68J44
db: uniprot

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot E2R4V2 162
organism: Canis lupus familiaris

uniprot K7CSV8 204
type: UnificationXref
id: K7CSV8
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot A0A3Q1LJZ7 325
organism: Bos taurus

uniprot Q8K4T5 255
type: UnificationXref
id: Q8K4T5
db: uniprot

PTHR24349:SF114
type: RelationshipXref
id: PTHR24349:SF114
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase pmk-2
type: ProteinReference
xref: PTHR24055:SF154
xref: uniprot Q8MXI4 350
organism: Caenorhabditis elegans

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 59

PTHR45992:SF3
type: RelationshipXref
id: PTHR45992:SF3
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__ATP-_CHOP-RIGHT__CHOP-_ADP-_r34
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 406
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 409
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 408
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 407
left: CHOP
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: CHOP

Bcl 2 s67 a97 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot P01108 74
xref: PTHR45851:SF1
organism: Mus musculus

uniprot Q93592 261
type: UnificationXref
id: Q93592
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QAU9 378
xref: PTHR48013:SF15
organism: Macaca mulatta

uniprot F6WA37 138
type: UnificationXref
id: F6WA37
db: uniprot

uniprot P45985 386
type: UnificationXref
id: P45985
db: uniprot

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot P01109 75
xref: PTHR45851:SF1
organism: Gallus gallus

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot P01106 73
xref: PTHR45851:SF1
organism: Homo sapiens

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: DISSOCIATION_LEFT__Complex__TRX_ASK_1_-RIGHT__TRX-_ASK_1-_r6
control type: ACTIVATION
controller: Oxidative Stress ROS, UV

uniprot P23583 77
type: UnificationXref
id: P23583
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RSB0 330
xref: PTHR24055:SF146
organism: Canis lupus familiaris

uniprot Q9NGL1 279
type: UnificationXref
id: Q9NGL1
db: uniprot

MEF 2 s63 a91 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q5VZP5 237
type: UnificationXref
id: Q5VZP5
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot Q91Y86 134
organism: Mus musculus

Serine/threonine/tyrosine-interacting protein
type: ProteinReference
xref: uniprot Q60969 239
organism: Mus musculus

uniprot Q7PNB0 249
type: UnificationXref
id: Q7PNB0
db: uniprot

DUSP18 isoform 7
type: ProteinReference
xref: uniprot H2QLH7 195
organism: Pan troglodytes

uniprot H9EP11 365
type: UnificationXref
id: H9EP11
db: uniprot

uniprot P35638 140
type: UnificationXref
id: P35638
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot P52564 28
organism: Homo sapiens

uniprot E1BCH7 362
type: UnificationXref
id: E1BCH7
db: uniprot

uniprot P22217 46
type: UnificationXref
id: P22217
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q9WTY9 355
organism: Rattus norvegicus

uniprot P41969 360
type: UnificationXref
id: P41969
db: uniprot

uniprot P01109 75
type: UnificationXref
id: P01109
db: uniprot

uniprot P09416 76
type: UnificationXref
id: P09416
db: uniprot

uniprot F7C5I2 177
type: UnificationXref
id: F7C5I2
db: uniprot

Dual specificity phosphatase 22 (Predicted), isoform CRA_a
type: ProteinReference
xref: uniprot D3ZC16 158
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9XVE7 289
organism: Caenorhabditis elegans

Dual specificity protein phosphatase 22
type: ProteinReference
xref: uniprot Q99N11 264
organism: Mus musculus

Stat1
type: Protein
entity reference: Stat1
feature: Stat1 s58 a82 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q9V429 63
type: UnificationXref
id: Q9V429
db: uniprot

uniprot P47712 319
type: UnificationXref
id: P47712
db: uniprot

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot F7AGV5 17
organism: Monodelphis domestica

PTHR24055:SF109
type: RelationshipXref
id: PTHR24055:SF109
db: PANTHER Family
relationship type: By Homology

Dual specificity phosphatase 14
type: ProteinReference
xref: uniprot F6PUA3 170
organism: Ornithorhynchus anatinus

PTHR24055:SF107
type: RelationshipXref
id: PTHR24055:SF107
db: PANTHER Family
relationship type: By Homology

uniprot A5PJP8 379
type: UnificationXref
id: A5PJP8
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05412 297
organism: Homo sapiens

uniprot F6Z879 383
type: UnificationXref
id: F6Z879
db: uniprot

uniprot Q6PCP3 246
type: UnificationXref
id: Q6PCP3
db: uniprot

PARTICIPANT STOICHIOMETRY r15 424
type: Stoichiometry
physical entity: cPLA2
stoichiometric coefficient: 1.0

uniprot D3ZAQ8 156
type: UnificationXref
id: D3ZAQ8
db: uniprot

uniprot F7BWL6 305
type: UnificationXref
id: F7BWL6
db: uniprot

PARTICIPANT STOICHIOMETRY r15 425
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r15 422
type: Stoichiometry
physical entity: cPLA2
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Elk_1-RIGHT__Elk_1-_ADP-_r22
controller: JNK1/2

Dual specificity protein phosphatase 14
type: ProteinReference
xref: uniprot O95147 210
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r15 423
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot Q9XVE7 289
type: UnificationXref
id: Q9XVE7
db: uniprot

uniprot A0A3Q1MNG1 8
type: UnificationXref
id: A0A3Q1MNG1
db: uniprot

uniprot Q9TXY8 62
type: UnificationXref
id: Q9TXY8
db: uniprot

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

Dual specificity phosphatase 21
type: ProteinReference
xref: uniprot Q9D9D8 271
organism: Mus musculus

uniprot F7A8S7 175
type: UnificationXref
id: F7A8S7
db: uniprot

uniprot Q9Z1B7 357
type: UnificationXref
id: Q9Z1B7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q93592 261
organism: Caenorhabditis elegans

Unknown
type: PhysicalEntity
cellular location: nucleus
comment: SPECIES_TYPE=UNKNOWN

PTHR11462:SF8
type: RelationshipXref
id: PTHR11462:SF8
db: PANTHER Family
relationship type: By Homology

Thioredoxin-1
type: ProteinReference
xref: uniprot P22217 46
organism: Saccharomyces cerevisiae

Evidence 312
type: Evidence
evidence code: ISS
comment: SPACC P50393

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 39

Eukaryotic elongation factor 2 kinase
type: ProteinReference
xref: PTHR45992:SF3
xref: uniprot O08796 94
organism: Mus musculus

uniprot P11232 45
type: UnificationXref
id: P11232
db: uniprot

uniprot F6YAB9 333
type: UnificationXref
id: F6YAB9
db: uniprot

DUSP21 isoform 1
type: ProteinReference
xref: uniprot H2RH74 201
organism: Pan troglodytes

Thioredoxin
type: ProteinReference
xref: PTHR10438:SF18
xref: uniprot F7H2R2 36
organism: Macaca mulatta

Myocyte enhancer factor 2C
type: ProteinReference
xref: uniprot F7FK48 108
xref: PTHR11945:SF25
organism: Ornithorhynchus anatinus

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__eEF2K-RIGHT__eEF2K-_re37
control type: INHIBITION
controller: p38

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9TY00 282
organism: Caenorhabditis elegans

uniprot Q8NEJ0 256
type: UnificationXref
id: Q8NEJ0
db: uniprot

PARTICIPANT STOICHIOMETRY r13 438
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 437
type: Stoichiometry
physical entity: MNK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 436
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot V6CIV8 293
type: UnificationXref
id: V6CIV8
db: uniprot

PARTICIPANT STOICHIOMETRY r13 435
type: Stoichiometry
physical entity: MNK1/2
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Translation
controller: MNK1/2

Dual specificity protein phosphatase 10
type: ProteinReference
xref: PTHR10159:SF299
xref: uniprot Q0IID7 218
organism: Bos taurus

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot O02812 336
xref: PTHR24055:SF110
organism: Canis lupus familiaris

P01137
type: UnificationXref
id: P01137
db: PANTHER Pathway Component

uniprot P22803 48
type: UnificationXref
id: P22803
db: uniprot

P01138
type: UnificationXref
id: P01138
db: PANTHER Pathway Component

DISSOCIATION
type: InteractionVocabulary

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot E2RKA7 329
organism: Canis lupus familiaris

Evidence 320
type: Evidence
evidence code: TAS
comment: SPACC P50393

uniprot Q8MXI4 350
type: UnificationXref
id: Q8MXI4
db: uniprot

uniprot F6TXC2 331
type: UnificationXref
id: F6TXC2
db: uniprot

uniprot P28574 306
type: UnificationXref
id: P28574
db: uniprot

Dual specificity protein phosphatase 4
type: ProteinReference
xref: uniprot Q13115 220
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r29 457
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r29 456
type: Stoichiometry
physical entity: Complex (Max/Myc)
stoichiometric coefficient: 1.0

uniprot P61244 309
type: UnificationXref
id: P61244
db: uniprot

PARTICIPANT STOICHIOMETRY r29 453
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r29 454
type: Stoichiometry
physical entity: Myc
stoichiometric coefficient: 1.0

TRX
type: ProteinReference
xref: P01122
standard name: thioredoxin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: thioredoxin Synonym: Synonym not specified Accession: P01122
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.TRX
member entity reference: Thioredoxin-2
member entity reference: Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
member entity reference: Thioredoxin
member entity reference: GEO12009p1
member entity reference: Thioredoxin domain-containing protein 2
member entity reference: Thioredoxin II
member entity reference: Thioredoxin-1
member entity reference: Uncharacterized protein

PARTICIPANT STOICHIOMETRY r29 455
type: Stoichiometry
physical entity: Max
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MNK1_2-_ATP-RIGHT__MNK1_2-_ADP-_r13
controller: p38

uniprot F7EEZ1 316
type: UnificationXref
id: F7EEZ1
db: uniprot

uniprot B0S6F4 361
type: UnificationXref
id: B0S6F4
db: uniprot

ncbitaxon 10116 13
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot O77627 296
type: UnificationXref
id: O77627
db: uniprot

ETS domain-containing protein Elk-1
type: ProteinReference
xref: uniprot P19419 359
xref: PTHR11849:SF178
organism: Homo sapiens

uniprot A0A2I3TFR7 301
type: UnificationXref
id: A0A2I3TFR7
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 27

PTHR24055:SF110
type: RelationshipXref
id: PTHR24055:SF110
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot Q9WTU6 136
xref: PTHR24055:SF172
organism: Mus musculus

ncbitaxon 39947 236
type: UnificationXref
id: 39947
db: ncbitaxon

Os01g0347000 protein
type: ProteinReference
xref: uniprot Q5Z8E0 238
organism: Oryza sativa

Dual specificity protein phosphatase 9
type: ProteinReference
xref: uniprot Q99956 263
organism: Homo sapiens

P01121
type: UnificationXref
id: P01121
db: PANTHER Pathway Component

PTHR24055:SF341
type: RelationshipXref
id: PTHR24055:SF341
db: PANTHER Family
relationship type: By Homology

uniprot Q60929 111
type: UnificationXref
id: Q60929
db: uniprot

P01125
type: UnificationXref
id: P01125
db: PANTHER Pathway Component

P01124
type: UnificationXref
id: P01124
db: PANTHER Pathway Component

P01123
type: UnificationXref
id: P01123
db: PANTHER Pathway Component

JNK1 2 s65 a45 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.63
comment: MODIFICATION_RESIDUE_NAME=

P01122
type: UnificationXref
id: P01122
db: PANTHER Pathway Component

uniprot F6ZKB3 124
type: UnificationXref
id: F6ZKB3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YFQ2 173
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6Y4G8 123
organism: Canis lupus familiaris

uniprot Q6PCS3 112
type: UnificationXref
id: Q6PCS3
db: uniprot

Protein max
type: ProteinReference
xref: PTHR10328:SF3
xref: uniprot P91664 310
organism: Drosophila melanogaster

DNA damage-inducible transcript 3 protein
type: ProteinReference
xref: uniprot Q0IIB6 142
xref: PTHR16833:SF0
organism: Bos taurus

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 84

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q9N272 354
organism: Pan troglodytes

Dual specificity protein phosphatase
type: ProteinReference
xref: uniprot E2R8S3 164
organism: Canis lupus familiaris

PTHR24055:SF146
type: RelationshipXref
id: PTHR24055:SF146
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein phosphatase yvh1
type: ProteinReference
xref: uniprot O13632 207
organism: Schizosaccharomyces pombe

P01130
type: UnificationXref
id: P01130
db: PANTHER Pathway Component

P01132
type: UnificationXref
id: P01132
db: PANTHER Pathway Component

P01131
type: UnificationXref
id: P01131
db: PANTHER Pathway Component

uniprot F7F2Q8 182
type: UnificationXref
id: F7F2Q8
db: uniprot

P01134
type: UnificationXref
id: P01134
db: PANTHER Pathway Component

P01133
type: UnificationXref
id: P01133
db: PANTHER Pathway Component

P01136
type: UnificationXref
id: P01136
db: PANTHER Pathway Component

MAP kinase-interacting serine/threonine-protein kinase 2 isoform 2
type: ProteinReference
xref: PTHR24349:SF254
xref: uniprot H9EP11 365
organism: Macaca mulatta

P01135
type: UnificationXref
id: P01135
db: PANTHER Pathway Component

DUSP3 isoform 1
type: ProteinReference
xref: uniprot H2RGU9 200
organism: Pan troglodytes

ncbitaxon 227321 50
type: UnificationXref
id: 227321
db: ncbitaxon

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6TXC2 331
xref: PTHR24055:SF107
organism: Monodelphis domestica

Myocyte-specific enhancer factor 2C
type: ProteinReference
xref: uniprot Q06413 110
xref: PTHR11945:SF25
organism: Homo sapiens

MEF-2
type: Protein
entity reference: MEF-2
feature: MEF 2 s62 a90 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

eEF2K
type: Protein
entity reference: eEF2K
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9D700 269
type: UnificationXref
id: Q9D700
db: uniprot

Max
type: Protein
entity reference: Max
feature: Max s54 a75 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F6WS85 106
type: UnificationXref
id: F6WS85
db: uniprot

P01127
type: UnificationXref
id: P01127
db: PANTHER Pathway Component

P01128
type: UnificationXref
id: P01128
db: PANTHER Pathway Component

P01129
type: UnificationXref
id: P01129
db: PANTHER Pathway Component

Protein CBR-MEF-2
type: ProteinReference
xref: PTHR11945:SF534
xref: uniprot A8XFG0 101
organism: Caenorhabditis briggsae

ncbitaxon 9031 42
type: UnificationXref
id: 9031
db: ncbitaxon

cPLA2
type: ProteinReference
xref: P01134
standard name: cytosolic phospholipase A2, group IVA
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.cPLA_sub_2
comment: ENTITY_REFERENCE_NOTES= Long Name: cytosolic phospholipase A2, group IVA Synonym: PLA2G4,cPLA2-alpha Accession: P01134
member entity reference: Phospholipase A2
member entity reference: Cytosolic phospholipase A2

MAP kinase-interacting serine/threonine kinase 2b
type: ProteinReference
xref: uniprot B0S6F4 361
organism: Danio rerio

uniprot O08648 385
type: UnificationXref
id: O08648
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6V332 332
xref: PTHR24055:SF110
organism: Macaca mulatta

Dual specificity phosphatase 27, atypical
type: ProteinReference
xref: uniprot H2R3E8 199
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FXI4 109
xref: PTHR11945:SF25
organism: Monodelphis domestica

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__ATP-_Myc-_Max-RIGHT__Complex__Max_Myc_-_ADP-_r29
controller: p38

Cell Survival
type: Pathway

uniprot F7F8P2 91
type: UnificationXref
id: F7F8P2
db: uniprot

TRANSCRIPTION
type: RelationshipTypeVocabulary

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LTT9 326
xref: PTHR24055:SF110
organism: Bos taurus

STATE_TRANSITION_LEFT__MKK3_6-_ATP-RIGHT__MKK3_6-_ADP-_r9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 415
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 414
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 417
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 416
left: MKK3/6
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: MKK3/6

uniprot F6PUA3 170
type: UnificationXref
id: F6PUA3
db: uniprot

uniprot E2R6T4 294
type: UnificationXref
id: E2R6T4
db: uniprot

uniprot Q95NE7 351
type: UnificationXref
id: Q95NE7
db: uniprot

uniprot F7HLA9 189
type: UnificationXref
id: F7HLA9
db: uniprot

PTHR11849:SF178
type: RelationshipXref
id: PTHR11849:SF178
db: PANTHER Family
relationship type: By Homology

uniprot A4FV00 118
type: UnificationXref
id: A4FV00
db: uniprot

uniprot Q8BFV3 253
type: UnificationXref
id: Q8BFV3
db: uniprot

uniprot F7G1T6 184
type: UnificationXref
id: F7G1T6
db: uniprot

PTHR24055:SF154
type: RelationshipXref
id: PTHR24055:SF154
db: PANTHER Family
relationship type: By Homology

Thioredoxin
type: ProteinReference
xref: PTHR10438:SF18
xref: uniprot P08629 41
organism: Gallus gallus

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 55

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

By Homology
type: RelationshipTypeVocabulary

uniprot A0A2I3RY19 145
type: UnificationXref
id: A0A2I3RY19
db: uniprot

STATE_TRANSITION_LEFT__ATP-_Stat1-RIGHT__ADP-_Stat1-_r31
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 413
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 411
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 412
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 410
left: ATP
left: Stat1
interaction type: STATE_TRANSITION
right: Stat1
right: ADP

Dual specificity phosphatase 10 (Predicted)
type: ProteinReference
xref: PTHR10159:SF299
xref: uniprot D3ZBG7 157
organism: Rattus norvegicus

Dual specificity protein phosphatase 7
type: ProteinReference
xref: uniprot Q16829 224
organism: Homo sapiens

Dual specificity protein phosphatase 6
type: ProteinReference
xref: uniprot Q16828 223
organism: Homo sapiens

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 25

uniprot Q9Y6W6 291
type: UnificationXref
id: Q9Y6W6
db: uniprot

uniprot A0A1D5R9X3 85
type: UnificationXref
id: A0A1D5R9X3
db: uniprot

Dual specificity protein phosphatase 21
type: ProteinReference
xref: uniprot F7DVA0 180
organism: Macaca mulatta

uniprot H2R0G7 127
type: UnificationXref
id: H2R0G7
db: uniprot

uniprot Q9UNI6 284
type: UnificationXref
id: Q9UNI6
db: uniprot

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
evidence: Evidence 375
xref: PTHR24349:SF114
xref: uniprot Q9BUB5 373
organism: Homo sapiens

uniprot Q75JM6 54
type: UnificationXref
id: Q75JM6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F7BD74 19
organism: Monodelphis domestica

uniprot F6U725 172
type: UnificationXref
id: F6U725
db: uniprot

uniprot O54838 208
type: UnificationXref
id: O54838
db: uniprot

MKK4
type: ProteinReference
xref: P01138
standard name: Mitogen-activated protein kinase kinase 4
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: MKK4 Synonym: JNKK,MAPKK4,MEK4,PRKMK4,SEK1 Accession: P01138
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.MKK4
member entity reference: Dual specificity mitogen-activated protein kinase kinase 4
member entity reference: Uncharacterized protein
member entity reference: MAP2K4 protein
member entity reference: Mitogen-activated protein kinase kinase 4
member entity reference: Mitogen-activated protein kinase kinase kinase 4
member entity reference: MAP2K4 isoform 3
member entity reference: Mitogen-activated protein kinase kinase 4A

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9XXK8 290
organism: Caenorhabditis elegans

uniprot Q9VVW5 287
type: UnificationXref
id: Q9VVW5
db: uniprot

ncbitaxon 9258 105
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot F1PBB6 381
type: UnificationXref
id: F1PBB6
db: uniprot

PTHR24055:SF172
type: RelationshipXref
id: PTHR24055:SF172
db: PANTHER Family
relationship type: By Homology

MKK3/6
type: Protein
entity reference: MKK3/6
feature: MKK3 6 s26 a33 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Dual specificity protein phosphatase 6
type: ProteinReference
xref: uniprot Q2KJ36 230
organism: Bos taurus

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q3T0N5 348
organism: Bos taurus

TRANSCRIPTION_LEFT__genes-RIGHT__genes-_re34
type: TemplateReaction
product: genes
xref: TRANSCRIPTION
participant: genes
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot O14463 38
type: UnificationXref
id: O14463
db: uniprot

uniprot E2RIJ6 90
type: UnificationXref
id: E2RIJ6
db: uniprot

Protein CBG03773
type: ProteinReference
xref: uniprot A8WWP5 155
organism: Caenorhabditis briggsae

uniprot P70531 95
type: UnificationXref
id: P70531
db: uniprot

uniprot Q3T0N5 348
type: UnificationXref
id: Q3T0N5
db: uniprot

CHOP
type: ProteinReference
xref: P01130
standard name: C/EBP-homologous protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: C/EBP-homologous protein Synonym: CEBPZ,DDIT3,GADD153 Accession: P01130
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.CHOP
member entity reference: DNA damage-inducible transcript 3 protein

uniprot P29429 49
type: UnificationXref
id: P29429
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

uniprot O97680 40
type: UnificationXref
id: O97680
db: uniprot

TRANSPORT
type: InteractionVocabulary

uniprot E2R8S3 164
type: UnificationXref
id: E2R8S3
db: uniprot

Myocyte enhancer factor 2ca
type: ProteinReference
xref: uniprot Q6PCS3 112
organism: Danio rerio

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_ATF_2-RIGHT__ATF_2-_ADP-_r24
controller: JNK1/2

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q16539 346
xref: PTHR24055:SF110
organism: Homo sapiens

uniprot H2QEM8 65
type: UnificationXref
id: H2QEM8
db: uniprot

uniprot E2R7W7 14
type: UnificationXref
id: E2R7W7
db: uniprot

uniprot B1H230 12
type: UnificationXref
id: B1H230
db: uniprot

Myocyte-specific enhancer factor 2A
type: ProteinReference
xref: uniprot Q60929 111
xref: PTHR11945:SF637
organism: Mus musculus

Stat1
type: ProteinReference
xref: P01125
standard name: Signal transducers and activators of transcription 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: signal transducer and activator of transcription 1 Synonym: ISGF-3,STAT91 Accession: P01125
comment: ENTITY_REFERENCE_ID_DESC=Oxidative stress response.PROTEIN.GENERIC.Stat1
member entity reference: Signal transducer and activator of transcription 1-alpha/beta
member entity reference: Signal transducer and activator of transcription 1
member entity reference: Signal transducer and activator of transcription

PTHR46115:SF1
type: RelationshipXref
id: PTHR46115:SF1
db: PANTHER Family
relationship type: By Homology

uniprot O09112 206
type: UnificationXref
id: O09112
db: uniprot

uniprot H2QCS1 194
type: UnificationXref
id: H2QCS1
db: uniprot

uniprot O42376 339
type: UnificationXref
id: O42376
db: uniprot

eco ECO:0000250 10
type: UnificationXref
id: ECO:0000250
db: eco

Phospholipase A2
type: ProteinReference
xref: uniprot F7HAF3 317
xref: PTHR10728:SF32
organism: Macaca mulatta

STATE_TRANSITION_LEFT__ATP-_MEF_2-RIGHT__ADP-_MEF_2-_r36
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 405
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 402
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 404
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 403
left: ATP
left: MEF-2
interaction type: STATE_TRANSITION
right: MEF-2
right: ADP

Myc
type: Protein
entity reference: Myc
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa4 395
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Jun proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: uniprot E2R6T4 294
xref: PTHR11462:SF8
organism: Canis lupus familiaris

uniprot Q7KQL8 56
type: UnificationXref
id: Q7KQL8
db: uniprot

STATE_TRANSITION_LEFT__ATP-_c_jun-RIGHT__c_jun-_ADP-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 451
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 449
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 452
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 450
left: ATP
left: c-jun
interaction type: STATE_TRANSITION
right: c-jun
right: ADP

DISSOCIATION_LEFT__Complex__TRX_ASK_1_-RIGHT__TRX-_ASK_1-_r6
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 434
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 433
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 432
left: Complex (TRX/ASK-1)
interaction type: DISSOCIATION
right: TRX
right: ASK-1

c-jun
type: Protein
entity reference: c-jun
feature: c jun s6 a6 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 3

Dual specificity protein phosphatase 1
type: ProteinReference
xref: uniprot Q9ZR37 292
organism: Arabidopsis thaliana

uniprot A0A452DIT1 150
type: UnificationXref
id: A0A452DIT1
db: uniprot

Dual specificity phosphatase 10
type: ProteinReference
xref: PTHR10159:SF299
xref: uniprot F7GDU1 185
organism: Ornithorhynchus anatinus

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot A0A0G2K3R1 377
xref: PTHR48016:SF32
organism: Rattus norvegicus

Thioredoxin
type: ProteinReference
xref: uniprot Q9TXY8 62
xref: PTHR45663:SF11
organism: Caenorhabditis elegans

uniprot Q9DBB1 273
type: UnificationXref
id: Q9DBB1
db: uniprot

uniprot O08911 337
type: UnificationXref
id: O08911
db: uniprot

Dual specificity phosphate 14
type: ProteinReference
xref: uniprot A1EC97 151
organism: Rattus norvegicus

Dual specificity protein phosphatase 5
type: ProteinReference
xref: uniprot O54838 208
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR10159:SF299
xref: uniprot F6U725 172
organism: Monodelphis domestica

ASK 1 s3 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ASK-1
stoichiometric coefficient: 1.0

uniprot F6QDY0 313
type: UnificationXref
id: F6QDY0
db: uniprot

PTHR10438:SF423
type: RelationshipXref
id: PTHR10438:SF423
db: PANTHER Family
relationship type: By Homology

Max
type: Protein
entity reference: Max
feature: Max s8 sa3 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa3 393
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

p38
type: Protein
entity reference: p38
feature: p38 s34 a43 rs1
feature: ACTIVE 32
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: PTHR24349:SF114
xref: uniprot Q58D94 369
organism: Bos taurus

Myc
type: Protein
entity reference: Myc
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5QAU9 378
type: UnificationXref
id: A0A1D5QAU9
db: uniprot

uniprot Q8CDB0 372
type: UnificationXref
id: Q8CDB0
db: uniprot

Elk 1 s40 a48 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Eukaryotic elongation factor 2 kinase
type: ProteinReference
xref: PTHR45992:SF3
xref: uniprot F7F8P2 91
organism: Macaca mulatta

Stat1 s57 a81 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A8WWP5 155
type: UnificationXref
id: A8WWP5
db: uniprot