MODEL_NOTES=Panther Pathway: P04392 The p53 pathway responds to stresses that can disrupt the fidelity of DNA replication and cell division. A stress signal is transmitted to the p53 protein by post-translational modifications. This results in the activation of the p53 protein as a transcription factor that initiates a program of cell cycle arrest, cellular senescence or apoptosis. The transcriptional network of p53-responsive genes produces proteins that interact with a large number of other signal transduction pathways in the cell and a number of positive and negative autoregulatory feedback loops act upon the p53 response. This diagram illustrates 3 such negative feedback loops. Medline=15838523 PMID: 15838523
ENTITY_REFERENCE_NOTES= Long Name: Delta Np73 Synonym: Synonym not specified Accession: P04537
ENTITY_REFERENCE_ID_DESC=P53 pathway feedback loops 1.PROTEIN.GENERIC.P73_delta_N
ENTITY_REFERENCE_NOTES= Long Name: Cop-1 Synonym: Synonym not specified Accession: G04683
ENTITY_REFERENCE_ID_DESC=P53 pathway feedback loops 1.GENE.GENE.Cop_minus_1
ENTITY_REFERENCE_NOTES= Long Name: Mouse double minute 2 Synonym: Synonym not specified Accession: P04536 Pathway Link: P00033|P04496|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04663|p53 pathway feedback loops 2*P00059|P01483|p53 pathway
ENTITY_REFERENCE_ID_DESC=P53 pathway feedback loops 1.PROTEIN.GENERIC.Mdm2
ENTITY_REFERENCE_ID_DESC=P53 pathway feedback loops 1.PROTEIN.GENERIC.Cop_minus_1
ENTITY_REFERENCE_NOTES= Long Name: Constitutively photomorphogenic 1 Synonym: Synonym not specified Accession: P04540
ENTITY_REFERENCE_NOTES= Long Name: P73DeltaN Synonym: Synonym not specified Accession: G04685
ENTITY_REFERENCE_ID_DESC=P53 pathway feedback loops 1.RNA.RNA.P73_Delta_N
ENTITY_REFERENCE_ID_DESC=P53 pathway feedback loops 1.GENE.GENE.P73
ENTITY_REFERENCE_NOTES= Long Name: Tumor protein p73 Synonym: p53-related protein p73 Accession: G04686
ENTITY_REFERENCE_ID_DESC=P53 pathway feedback loops 1.PROTEIN.GENERIC.P53
ENTITY_REFERENCE_NOTES= Long Name: P53 Synonym: Synonym not specified Accession: P04539 Pathway Link: P00006|P00273|Apoptosis signaling pathway*P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04668|p53 pathway feedback loops 2*P00059|P01485|p53 pathway