Tumor protein p73
type: DnaReference
xref: PTHR11447:SF21
organism: Macaca mulatta

Complex (Cop-1/P53)
type: Complex
component stoichiometry: P53 s13 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cop 1 s12 sa1 STOICHIOMETRY ID COMPLEX
component: Cop-1
component: P53
feature: COMPLEX BINDING FEATURE s15 a25 69
feature: COMPLEX BINDING FEATURE s15 a25 67

COP1, E3 ubiquitin ligase
type: DnaReference
xref: PTHR44080:SF1
organism: Xenopus tropicalis

P53 responsive genes
type: RnaRegion
comment: SPECIES_TYPE=RNA

Tumor protein 63 (p63)
type: ProteinReference
xref: uniprot H2QNY5 43
xref: PTHR11447:SF8
organism: Pan troglodytes

Tumor protein p73
type: DnaReference
xref: PTHR11447:SF21
organism: Bos taurus

MDM2 proto-oncogene
type: ProteinReference
xref: uniprot A0A2I3RE00 13
xref: PTHR13844:SF15
organism: Pan troglodytes

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Cop_1-RIGHT__Cop_1-_re28
control type: ACTIVATION
controller: P53

uniprot P56424 58
type: UnificationXref
id: P56424
db: uniprot

DISSOCIATION_LEFT__Ub-_Complex__Pirh_1_P53_-RIGHT__P53-_Pirh_1-_re18
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 80
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 77
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 78
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 79
left: Complex (Pirh-1/P53)
left: Ub
interaction type: DISSOCIATION
right: Pirh-1
right: P53

ACTIVE 30
type: EntityFeature
comment: Active state

Tumor protein 63 (p63)
type: ProteinReference
xref: uniprot F1PL57 40
xref: PTHR11447:SF8
organism: Canis lupus familiaris

Pirh-1
type: DnaRegion
comment: SPECIES_TYPE=GENE

uniprot H2QNY5 43
type: UnificationXref
id: H2QNY5
db: uniprot

uniprot Q29537 61
type: UnificationXref
id: Q29537
db: uniprot

P53 responsive genes
type: DnaRegion
comment: SPECIES_TYPE=GENE

Tumor protein 63
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot Q9H3D4 45
organism: Homo sapiens

PTHR11447:SF8
type: RelationshipXref
id: PTHR11447:SF8
db: PANTHER Family
relationship type: By Homology

PTHR11447:SF6
type: RelationshipXref
id: PTHR11447:SF6
db: PANTHER Family
relationship type: By Homology

P73
type: DnaRegion
entity reference: Tumor protein p73
comment: SPECIES_TYPE=GENE

uniprot D4AA88 48
type: UnificationXref
id: D4AA88
db: uniprot

Tumor protein 63 (p63)
type: ProteinReference
xref: uniprot A0A167VDT2 37
xref: PTHR11447:SF8
organism: Gallus gallus

uniprot P04637 56
type: UnificationXref
id: P04637
db: uniprot

ncbitaxon 10090 10
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot Q5XIN1 29
type: UnificationXref
id: Q5XIN1
db: uniprot

Protein Mdm4
type: ProteinReference
xref: uniprot F7GQ86 18
organism: Macaca mulatta

uniprot P23804 27
type: UnificationXref
id: P23804
db: uniprot

Pirh 1 s14 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pirh-1
stoichiometric coefficient: 1.0

Mus musculus
type: BioSource
xref: ncbitaxon 10090 10

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: PTHR13844:SF15
xref: uniprot Q00987 28
organism: Homo sapiens

Pirh-1
type: Protein
comment: SPECIES_TYPE=PROTEIN

Tumor protein p73
type: DnaReference
xref: PTHR11447:SF21
organism: Mus musculus

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot B0S576 47
organism: Danio rerio

uniprot P67939 59
type: UnificationXref
id: P67939
db: uniprot

uniprot E2RDT3 14
type: UnificationXref
id: E2RDT3
db: uniprot

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

P73DeltaN
type: Protein
entity reference: P73deltaN
feature: ACTIVE 30
comment: SPECIES_TYPE=PROTEIN

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: PTHR13844:SF15
xref: uniprot F1MYE6 16
organism: Bos taurus

uniprot F1MKA9 39
type: UnificationXref
id: F1MKA9
db: uniprot

P53 pathway feedback loops 1
type: Pathway
pathway component: TRANSLATION_LEFT__P73DeltaN-RIGHT__P73DeltaN-_re25
pathway component: STATE_TRANSITION_LEFT__P53-RIGHT__a27_degraded-_re19
pathway component: DISSOCIATION_LEFT__Ub-_Complex__Pirh_1_P53_-RIGHT__P53-_Pirh_1-_re18
pathway component: STATE_TRANSITION_LEFT__P53-RIGHT__a29_degraded-_re21
pathway component: TRANSCRIPTION_LEFT__P53_responsive_genes-RIGHT__P53_responsive_genes-_re32
pathway component: TRANSLATION_LEFT__Cop_1-RIGHT__Cop_1-_re29
pathway component: STATE_TRANSITION_LEFT__P53-RIGHT__a28_degraded-_re20
pathway component: TRANSCRIPTION_LEFT__Pirh_1-RIGHT__Pirh_1-_re30
pathway component: TRANSCRIPTION_LEFT__P73-RIGHT__P73DeltaN-_re24
pathway component: HETERODIMER_ASSOCIATION_LEFT__P53-_Mdm2-RIGHT__Complex__Mdm2_P53_-_re22
pathway component: HETERODIMER_ASSOCIATION_LEFT__Pirh_1-_P53-RIGHT__Complex__Pirh_1_P53_-_re15
pathway component: HETERODIMER_ASSOCIATION_LEFT__Cop_1-_P53-RIGHT__Complex__Cop_1_P53_-_re14
pathway component: DISSOCIATION_LEFT__Ub-_Complex__Mdm2_P53_-RIGHT__P53-_Mdm2-_re23
pathway component: TRANSCRIPTION_LEFT__Cop_1-RIGHT__Cop_1-_re28
pathway component: TRANSCRIPTION_LEFT__Mdm2-RIGHT__Mdm2-_re26
pathway component: TRANSLATION_LEFT__Pirh_1-RIGHT__Pirh_1-_re31
pathway component: DISSOCIATION_LEFT__Complex__Cop_1_P53_-_Ub-RIGHT__P53-_Cop_1-_re17
pathway component: TRANSLATION_LEFT__Mdm2-RIGHT__Mdm2-_re27
xref: PANTHER Pathway P04392 1
comment: MODEL_NOTES=Panther Pathway: P04392 The p53 pathway responds to stresses that can disrupt the fidelity of DNA replication and cell division. A stress signal is transmitted to the p53 protein by post-translational modifications. This results in the activation of the p53 protein as a transcription factor that initiates a program of cell cycle arrest, cellular senescence or apoptosis. The transcriptional network of p53-responsive genes produces proteins that interact with a large number of other signal transduction pathways in the cell and a number of positive and negative autoregulatory feedback loops act upon the p53 response. This diagram illustrates 3 such negative feedback loops. Medline=15838523 PMID: 15838523

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 3

HETERODIMER_ASSOCIATION_LEFT__Cop_1-_P53-RIGHT__Complex__Cop_1_P53_-_re14
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 88
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 90
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 89
left: Cop-1
left: P53
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Cop-1/P53)

uniprot Q8NHY2 35
type: UnificationXref
id: Q8NHY2
db: uniprot

PARTICIPANT STOICHIOMETRY re22 95
type: Stoichiometry
physical entity: P53
stoichiometric coefficient: 1.0

Tumor protein p73
type: DnaReference
xref: PTHR11447:SF21
organism: Danio rerio

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot F1MKA9 39
organism: Bos taurus

uniprot A0A0G2JVC1 11
type: UnificationXref
id: A0A0G2JVC1
db: uniprot

uniprot O88898 44
type: UnificationXref
id: O88898
db: uniprot

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot G3X6J7 52
organism: Bos taurus

PTHR44080:SF1
type: RelationshipXref
id: PTHR44080:SF1
db: PANTHER Family
relationship type: By Homology

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: uniprot P23804 27
xref: PTHR13844:SF15
organism: Mus musculus

Protein Mdm4
type: ProteinReference
xref: uniprot F1N736 17
organism: Bos taurus

lys P53 s23 sa4 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY lys
feature location: lys P53 s23 sa4 rs1 lys
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793
comment: MODIFICATION_RESIDUE_NAME=lys

Mdm2
type: DnaRegion
comment: SPECIES_TYPE=GENE

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P56424 58
organism: Macaca mulatta

PANTHER Pathway P04392 1
type: UnificationXref
id: P04392
db: PANTHER Pathway

uniprot F1PL57 40
type: UnificationXref
id: F1PL57
db: uniprot

PARTICIPANT STOICHIOMETRY re22 97
type: Stoichiometry
physical entity: Complex (Mdm2/P53)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re22 96
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

P53
type: Protein
entity reference: P53
feature: lys P53 s25 sa6 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa6 66
feature: ACTIVE 30
comment: SPECIES_TYPE=PROTEIN

Pirh-1
type: Protein
feature: ACTIVE 30
comment: SPECIES_TYPE=PROTEIN

TRANSLATION
type: RelationshipTypeVocabulary

uniprot H9FUJ1 21
type: UnificationXref
id: H9FUJ1
db: uniprot

lys P53 s13 sa2 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY lys
feature location: lys P53 s13 sa2 rs1 lys
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793
comment: MODIFICATION_RESIDUE_NAME=lys

uniprot H2QC53 53
type: UnificationXref
id: H2QC53
db: uniprot

TRANSCRIPTION
type: InteractionVocabulary

PARTICIPANT STOICHIOMETRY re20 101
type: Stoichiometry
physical entity: a28_degraded
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re23 94
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 76
type: Stoichiometry
physical entity: a27_degraded
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re20 100
type: Stoichiometry
physical entity: P53
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re23 93
type: Stoichiometry
physical entity: P53
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 75
type: Stoichiometry
physical entity: P53
stoichiometric coefficient: 1.0

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 7

PARTICIPANT STOICHIOMETRY re23 92
type: Stoichiometry
physical entity: Complex (Mdm2/P53)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re23 91
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 6

ncbitaxon 9544 19
type: UnificationXref
id: 9544
db: ncbitaxon

P73deltaN
type: ProteinReference
xref: P04537
standard name: Tumor protein p73 delta-N variant
comment: ENTITY_REFERENCE_NOTES= Long Name: Delta Np73 Synonym: Synonym not specified Accession: P04537
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=P53 pathway feedback loops 1.PROTEIN.GENERIC.P73_delta_N
member entity reference: Tumor protein 63 (p63)
member entity reference: Tumor protein 63

Complex (Pirh-1/P53)
type: Complex
component stoichiometry: P53 s23 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pirh 1 s14 sa3 STOICHIOMETRY ID COMPLEX
component: Pirh-1
component: P53
feature: COMPLEX BINDING FEATURE s16 a26 71
feature: COMPLEX BINDING FEATURE s16 a26 73

E3 ubiquitin-protein ligase COP1
type: ProteinReference
xref: uniprot Q9R1A8 36
xref: PTHR44080:SF1
organism: Mus musculus

DISSOCIATION
type: InteractionVocabulary

G04686
type: UnificationXref
id: G04686
db: PANTHER Pathway Component

uniprot O15151 22
type: UnificationXref
id: O15151
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Pirh_1-_P53-RIGHT__Complex__Pirh_1_P53_-_re15
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 85
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 87
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 86
left: Pirh-1
left: P53
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Pirh-1/P53)

G04683
type: UnificationXref
id: G04683
db: PANTHER Pathway Component

uniprot P79734 60
type: UnificationXref
id: P79734
db: uniprot

P53 s13 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: P53
stoichiometric coefficient: 1.0

Protein Mdm4
type: ProteinReference
xref: uniprot Q5XIN1 29
organism: Rattus norvegicus

Cop-1
type: RnaRegion
comment: SPECIES_TYPE=RNA

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__P73-RIGHT__P73DeltaN-_re24
control type: ACTIVATION
controller: P53

lys P53 s1 a1 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY lys
feature location: lys P53 s1 a1 rs1 lys
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793
comment: MODIFICATION_RESIDUE_NAME=lys

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot Q29537 61
xref: PTHR11447:SF6
organism: Canis lupus familiaris

uniprot O42354 24
type: UnificationXref
id: O42354
db: uniprot

Mdm2
type: Protein
entity reference: Mdm2
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa5 64
feature: ACTIVE 30
comment: SPECIES_TYPE=PROTEIN

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 8

BOOLEAN_LOGIC_GATE_AND
type: TemplateReactionRegulation
xref: BOOLEAN LOGIC GATE AND
controlled: TRANSCRIPTION_LEFT__P53_responsive_genes-RIGHT__P53_responsive_genes-_re32

ncbitaxon 9615 15
type: UnificationXref
id: 9615
db: ncbitaxon

lys P53 s25 sa6 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY lys
feature location: lys P53 s25 sa6 rs1 lys
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793
comment: MODIFICATION_RESIDUE_NAME=lys

By Homology
type: RelationshipTypeVocabulary

eco ECO:0000304 50
type: UnificationXref
id: ECO:0000304
db: eco

PARTICIPANT STOICHIOMETRY re18 80
type: Stoichiometry
physical entity: Pirh-1
stoichiometric coefficient: 1.0

Constitutively photomorphogenic 1
type: DnaRegionReference
member entity reference: COP1, E3 ubiquitin ligase
member entity reference: E3 ubiquitin-protein ligase COP1
xref: G04683
comment: ENTITY_REFERENCE_NOTES= Long Name: Cop-1 Synonym: Synonym not specified Accession: G04683
comment: ENTITY_REFERENCE_ID_DESC=P53 pathway feedback loops 1.GENE.GENE.Cop_minus_1
display name: Cop-1

Mdm2
type: ProteinReference
xref: P04536
standard name: Mouse double minute 2
comment: ENTITY_REFERENCE_NOTES= Long Name: Mouse double minute 2 Synonym: Synonym not specified Accession: P04536 Pathway Link: P00033|P04496|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04663|p53 pathway feedback loops 2*P00059|P01483|p53 pathway
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=P53 pathway feedback loops 1.PROTEIN.GENERIC.Mdm2
member entity reference: E3 ubiquitin-protein ligase Mdm2
member entity reference: Protein Mdm4
member entity reference: MDM2 proto-oncogene

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: PTHR13844:SF15
xref: uniprot O42354 24
organism: Danio rerio

uniprot F1N736 17
type: UnificationXref
id: F1N736
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__P53_responsive_genes-RIGHT__P53_responsive_genes-_re32
control type: ACTIVATION
controller: P73DeltaN

uniprot F7GA51 51
type: UnificationXref
id: F7GA51
db: uniprot

TRANSLATION_LEFT__P73DeltaN-RIGHT__P73DeltaN-_re25
type: TemplateReaction
product: P73DeltaN
xref: TRANSLATION
participant: P73DeltaN
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot H2QC53 53
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re17 81
type: Stoichiometry
physical entity: Complex (Cop-1/P53)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 82
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 83
type: Stoichiometry
physical entity: P53
stoichiometric coefficient: 1.0

Tumor protein 63
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot O88898 44
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re17 84
type: Stoichiometry
physical entity: Cop-1
stoichiometric coefficient: 1.0

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot F7FN64 42
organism: Macaca mulatta

COP1, E3 ubiquitin ligase
type: DnaReference
xref: PTHR44080:SF1
organism: Ornithorhynchus anatinus

uniprot P10361 57
type: UnificationXref
id: P10361
db: uniprot

ncbitaxon 7955 25
type: UnificationXref
id: 7955
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re18 77
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re18 78
type: Stoichiometry
physical entity: Complex (Pirh-1/P53)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re18 79
type: Stoichiometry
physical entity: P53
stoichiometric coefficient: 1.0

uniprot O35618 23
type: UnificationXref
id: O35618
db: uniprot

uniprot F7CIC4 33
type: UnificationXref
id: F7CIC4
db: uniprot

uniprot F1MYE6 16
type: UnificationXref
id: F1MYE6
db: uniprot

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: PTHR13844:SF15
xref: uniprot H9FUJ1 21
organism: Macaca mulatta

Danio rerio
type: BioSource
xref: ncbitaxon 7955 25

P53
type: Protein
entity reference: P53
feature: lys P53 s1 a1 rs1
feature: ACTIVE 30
comment: SPECIES_TYPE=PROTEIN

Cellular tumor antigen p53
type: ProteinReference
xref: uniprot P79734 60
xref: PTHR11447:SF6
organism: Danio rerio

E3 ubiquitin-protein ligase Mdm2
type: ProteinReference
xref: PTHR13844:SF15
xref: uniprot A0A0G2JVC1 11
organism: Rattus norvegicus

Protein Mdm4
type: ProteinReference
xref: uniprot O15151 22
organism: Homo sapiens

P53
type: Protein
entity reference: P53
feature: lys P53 s23 sa4 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa4 74
feature: ACTIVE 30
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Mdm2-RIGHT__Mdm2-_re26
control type: ACTIVATION
controller: P53

uniprot F1MHX1 31
type: UnificationXref
id: F1MHX1
db: uniprot

uniprot Q9R1A8 36
type: UnificationXref
id: Q9R1A8
db: uniprot

Mdm2
type: Protein
entity reference: Mdm2
comment: SPECIES_TYPE=PROTEIN

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P10361 57
organism: Rattus norvegicus

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot O15350 54
organism: Homo sapiens

COP1, E3 ubiquitin ligase
type: ProteinReference
xref: uniprot F6PJK3 32
xref: PTHR44080:SF1
organism: Ornithorhynchus anatinus

Protein Mdm4
type: ProteinReference
xref: uniprot E2RDT3 14
organism: Canis lupus familiaris

TRANSCRIPTION
type: RelationshipTypeVocabulary

uniprot Q9JJP2 62
type: UnificationXref
id: Q9JJP2
db: uniprot

uniprot H2R8E1 34
type: UnificationXref
id: H2R8E1
db: uniprot

uniprot G3X6J7 52
type: UnificationXref
id: G3X6J7
db: uniprot

Protein Mdm4
type: ProteinReference
xref: uniprot H2R875 20
organism: Pan troglodytes

TRANSCRIPTION_LEFT__Mdm2-RIGHT__Mdm2-_re26
type: TemplateReaction
product: Mdm2
xref: TRANSCRIPTION
participant: Mdm2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot H2R875 20
type: UnificationXref
id: H2R875
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 2

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P04637 56
organism: Homo sapiens

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 19

uniprot P02340 55
type: UnificationXref
id: P02340
db: uniprot

TRANSLATION
type: InteractionVocabulary

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 5

DISSOCIATION_LEFT__Complex__Cop_1_P53_-_Ub-RIGHT__P53-_Cop_1-_re17
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 81
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 83
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 84
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 82
left: Ub
left: Complex (Cop-1/P53)
interaction type: DISSOCIATION
right: Cop-1
right: P53

uniprot F7FN64 42
type: UnificationXref
id: F7FN64
db: uniprot

Mdm2 s24 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Mdm2
stoichiometric coefficient: 1.0

ncbitaxon 9031 38
type: UnificationXref
id: 9031
db: ncbitaxon

a27_degraded
type: PhysicalEntity
comment: SPECIES_TYPE=DEGRADED

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 50

COP1, E3 ubiquitin ligase
type: ProteinReference
xref: uniprot F7CIC4 33
xref: PTHR44080:SF1
organism: Xenopus tropicalis

Tumor protein p73
type: DnaReference
xref: PTHR11447:SF21
organism: Homo sapiens

a29_degraded
type: PhysicalEntity
comment: SPECIES_TYPE=DEGRADED

P04540
type: UnificationXref
id: P04540
db: PANTHER Pathway Component

uniprot A0A167VDT2 37
type: UnificationXref
id: A0A167VDT2
db: uniprot

STATE_TRANSITION_LEFT__P53-RIGHT__a28_degraded-_re20
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 100
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 101
left: P53
interaction type: STATE_TRANSITION
right: a28_degraded

Cop-1
type: ProteinReference
xref: P04540
standard name: Constitutively photomorphogenic 1
comment: ENTITY_REFERENCE_ID_DESC=P53 pathway feedback loops 1.PROTEIN.GENERIC.Cop_minus_1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Constitutively photomorphogenic 1 Synonym: Synonym not specified Accession: P04540
member entity reference: COP1, E3 ubiquitin ligase
member entity reference: E3 ubiquitin-protein ligase COP1

STATE_TRANSITION_LEFT__P53-RIGHT__a29_degraded-_re21
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 98
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 99
left: P53
interaction type: STATE_TRANSITION
right: a29_degraded

Ub
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Cop-1
type: Protein
entity reference: Cop-1
feature: ACTIVE 30
comment: SPECIES_TYPE=PROTEIN

uniprot F6PJK3 32
type: UnificationXref
id: F6PJK3
db: uniprot

eco ECO:0000250 3
type: UnificationXref
id: ECO:0000250
db: eco

uniprot Q00987 28
type: UnificationXref
id: Q00987
db: uniprot

DISSOCIATION
type: RelationshipTypeVocabulary

Cop-1
type: Protein
entity reference: Cop-1
comment: SPECIES_TYPE=PROTEIN

P04539
type: UnificationXref
id: P04539
db: PANTHER Pathway Component

P04536
type: UnificationXref
id: P04536
db: PANTHER Pathway Component

P04537
type: UnificationXref
id: P04537
db: PANTHER Pathway Component

P53
type: Protein
entity reference: P53
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa2 70
feature: ACTIVE 30
feature: lys P53 s13 sa2 rs1
comment: SPECIES_TYPE=PROTEIN

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 12

STATE_TRANSITION_LEFT__P53-RIGHT__a27_degraded-_re19
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 75
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 76
left: P53
interaction type: STATE_TRANSITION
right: a27_degraded

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 15

TRANSCRIPTION_LEFT__P53_responsive_genes-RIGHT__P53_responsive_genes-_re32
type: TemplateReaction
product: P53 responsive genes
xref: TRANSCRIPTION
participant: P53 responsive genes
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Cop-1
type: Protein
entity reference: Cop-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa1 68
feature: ACTIVE 30
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re15 86
type: Stoichiometry
physical entity: P53
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re15 85
type: Stoichiometry
physical entity: Pirh-1
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__Pirh_1-RIGHT__Pirh_1-_re30
type: TemplateReaction
product: Pirh-1
xref: TRANSCRIPTION
participant: Pirh-1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

COP1, E3 ubiquitin ligase
type: ProteinReference
xref: PTHR44080:SF1
xref: uniprot F1MHX1 31
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re15 87
type: Stoichiometry
physical entity: Complex (Pirh-1/P53)
stoichiometric coefficient: 1.0

TRANSLATION_LEFT__Pirh_1-RIGHT__Pirh_1-_re31
type: TemplateReaction
product: Pirh-1
xref: TRANSLATION
participant: Pirh-1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

PARTICIPANT STOICHIOMETRY re21 98
type: Stoichiometry
physical entity: P53
stoichiometric coefficient: 1.0

PTHR11447:SF21
type: RelationshipXref
id: PTHR11447:SF21
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3RE00 13
type: UnificationXref
id: A0A2I3RE00
db: uniprot

ncbitaxon 9606 8
type: UnificationXref
id: 9606
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re21 99
type: Stoichiometry
physical entity: a29_degraded
stoichiometric coefficient: 1.0

Mdm2
type: RnaRegion
comment: SPECIES_TYPE=RNA

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot F7DUR2 41
organism: Ornithorhynchus anatinus

TRANSCRIPTION_LEFT__Cop_1-RIGHT__Cop_1-_re28
type: TemplateReaction
product: Cop-1
xref: TRANSCRIPTION
participant: Cop-1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Tumor protein 63 (p63)
type: ProteinReference
xref: PTHR11447:SF8
xref: uniprot E9QG65 49
organism: Danio rerio

PTHR13844:SF15
type: RelationshipXref
id: PTHR13844:SF15
db: PANTHER Family
relationship type: By Homology

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 38

TRANSLATION_LEFT__Mdm2-RIGHT__Mdm2-_re27
type: TemplateReaction
product: Mdm2
xref: TRANSLATION
participant: Mdm2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

HETERODIMER_ASSOCIATION_LEFT__P53-_Mdm2-RIGHT__Complex__Mdm2_P53_-_re22
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 96
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 97
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 95
left: P53
left: Mdm2
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Mdm2/P53)

ncbitaxon 9913 2
type: UnificationXref
id: 9913
db: ncbitaxon

P73DeltaN
type: RnaRegion
entity reference: P73DeltaN
comment: SPECIES_TYPE=RNA

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P02340 55
organism: Mus musculus

ncbitaxon 8364 6
type: UnificationXref
id: 8364
db: ncbitaxon

Pirh-1
type: RnaRegion
comment: SPECIES_TYPE=RNA

lys P53 s17 a27 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY lys
feature location: lys P53 s17 a27 rs1 lys
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793
comment: MODIFICATION_RESIDUE_NAME=lys

BOOLEAN_LOGIC_GATE_AND
type: RelationshipTypeVocabulary

uniprot F7DUR2 41
type: UnificationXref
id: F7DUR2
db: uniprot

E3 ubiquitin-protein ligase COP1
type: ProteinReference
xref: uniprot Q8NHY2 35
xref: PTHR44080:SF1
organism: Homo sapiens

TRANSCRIPTION_LEFT__P73-RIGHT__P73DeltaN-_re24
type: TemplateReaction
product: P73DeltaN
xref: TRANSCRIPTION
participant: P73
participant: P73DeltaN
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

TRANSLATION_LEFT__Cop_1-RIGHT__Cop_1-_re29
type: TemplateReaction
product: Cop-1
xref: TRANSLATION
participant: Cop-1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

P53
type: Protein
entity reference: P53
feature: lys P53 s17 a27 rs1
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__P53_responsive_genes-RIGHT__P53_responsive_genes-_re32
control type: ACTIVATION
controller: P53

Cop 1 s12 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cop-1
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__Pirh_1-RIGHT__Pirh_1-_re30
control type: ACTIVATION
controller: P53

ncbitaxon 9258 5
type: UnificationXref
id: 9258
db: ncbitaxon

Pirh-1
type: Protein
feature: ACTIVE 30
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa3 72
comment: SPECIES_TYPE=PROTEIN

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot D4AA88 48
organism: Rattus norvegicus

COP1, E3 ubiquitin ligase
type: ProteinReference
xref: uniprot H2R8E1 34
xref: PTHR44080:SF1
organism: Pan troglodytes

ncbitaxon 9598 7
type: UnificationXref
id: 9598
db: ncbitaxon

P73DeltaN
type: RnaRegionReference
comment: ENTITY_REFERENCE_NOTES= Long Name: P73DeltaN Synonym: Synonym not specified Accession: G04685
comment: ENTITY_REFERENCE_ID_DESC=P53 pathway feedback loops 1.RNA.RNA.P73_Delta_N

E3 ubiquitin-protein ligase COP1
type: DnaReference
xref: PTHR44080:SF1
organism: Homo sapiens

E3 ubiquitin-protein ligase COP1
type: DnaReference
xref: PTHR44080:SF1
organism: Mus musculus

COP1, E3 ubiquitin ligase
type: DnaReference
xref: PTHR44080:SF1
organism: Pan troglodytes

uniprot B0S576 47
type: UnificationXref
id: B0S576
db: uniprot

PARTICIPANT STOICHIOMETRY re14 90
type: Stoichiometry
physical entity: Complex (Cop-1/P53)
stoichiometric coefficient: 1.0

uniprot O15350 54
type: UnificationXref
id: O15350
db: uniprot

Tumor protein p73
type: DnaReference
xref: PTHR11447:SF21
organism: Rattus norvegicus

P53 s23 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: P53
stoichiometric coefficient: 1.0

Mdm2
type: Protein
entity reference: Mdm2
feature: ACTIVE 30
comment: SPECIES_TYPE=PROTEIN

uniprot Q9JJP6 46
type: UnificationXref
id: Q9JJP6
db: uniprot

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 26

ncbitaxon 10116 12
type: UnificationXref
id: 10116
db: ncbitaxon

Tumor protein p73
type: DnaRegionReference
member entity reference: Tumor protein p73
xref: G04686
comment: ENTITY_REFERENCE_ID_DESC=P53 pathway feedback loops 1.GENE.GENE.P73
comment: ENTITY_REFERENCE_NOTES= Long Name: Tumor protein p73 Synonym: p53-related protein p73 Accession: G04686
display name: P73

uniprot Q9H3D4 45
type: UnificationXref
id: Q9H3D4
db: uniprot

IDA
type: EvidenceCodeVocabulary

DISSOCIATION_LEFT__Ub-_Complex__Mdm2_P53_-RIGHT__P53-_Mdm2-_re23
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 94
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 92
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 91
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 93
left: Complex (Mdm2/P53)
left: Ub
interaction type: DISSOCIATION
right: Mdm2
right: P53

PARTICIPANT STOICHIOMETRY re14 88
type: Stoichiometry
physical entity: Cop-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re14 89
type: Stoichiometry
physical entity: P53
stoichiometric coefficient: 1.0

uniprot F7GQ86 18
type: UnificationXref
id: F7GQ86
db: uniprot

COP1, E3 ubiquitin ligase
type: DnaReference
xref: PTHR44080:SF1
organism: Bos taurus

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot F7GA51 51
organism: Macaca mulatta

Tumor protein p73
type: ProteinReference
xref: PTHR11447:SF21
xref: uniprot Q9JJP2 62
organism: Mus musculus

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

P53 s25 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: P53
stoichiometric coefficient: 1.0

Cop-1
type: DnaRegion
entity reference: Constitutively photomorphogenic 1
comment: SPECIES_TYPE=GENE

Tumor protein 63
type: ProteinReference
xref: uniprot Q9JJP6 46
xref: PTHR11447:SF8
organism: Rattus norvegicus

P53
type: ProteinReference
xref: P04539
standard name: Tumor protein p53
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=P53 pathway feedback loops 1.PROTEIN.GENERIC.P53
comment: ENTITY_REFERENCE_NOTES= Long Name: P53 Synonym: Synonym not specified Accession: P04539 Pathway Link: P00006|P00273|Apoptosis signaling pathway*P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04398|P04668|p53 pathway feedback loops 2*P00059|P01485|p53 pathway
member entity reference: Cellular tumor antigen p53
member entity reference: Tumor protein 63 (p63)
member entity reference: Tumor protein 63
member entity reference: Tumor protein p73

eco ECO:0000316 26
type: UnificationXref
id: ECO:0000316
db: eco

a28_degraded
type: PhysicalEntity
comment: SPECIES_TYPE=DEGRADED

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P67939 59
organism: Bos taurus

Protein Mdm4
type: ProteinReference
xref: uniprot O35618 23
organism: Mus musculus

Complex (Mdm2/P53)
type: Complex
component stoichiometry: Mdm2 s24 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: P53 s25 sa6 STOICHIOMETRY ID COMPLEX
component: Mdm2
component: P53
feature: COMPLEX BINDING FEATURE s21 a38 63
feature: COMPLEX BINDING FEATURE s21 a38 65

uniprot E9QG65 49
type: UnificationXref
id: E9QG65
db: uniprot