Mitogen-activated protein kinase 6
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot E2QVF3 116
organism: Canis lupus familiaris

uniprot P17252 305
type: UnificationXref
id: P17252
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot F6SZ66 768
xref: PTHR10048:SF7
organism: Monodelphis domestica

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 2

GSK3 s103 a145 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q3T0F9 259
type: UnificationXref
id: Q3T0F9
db: uniprot

uniprot P22126 442
type: UnificationXref
id: P22126
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A452DI16 578
xref: PTHR44329:SF55
organism: Bos taurus

Ca2+
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=ION

uniprot Q2HJ27 887
type: UnificationXref
id: Q2HJ27
db: uniprot

Mitogen-activated protein kinase 6
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot Q16659 160
organism: Homo sapiens

PKB
type: Protein
entity reference: PKB
feature: PKB s15 a102 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF12
xref: uniprot H2QIH7 280
organism: Pan troglodytes

uniprot F6SDH6 50
type: UnificationXref
id: F6SDH6
db: uniprot

uniprot B4F7D4 9
type: UnificationXref
id: B4F7D4
db: uniprot

Os01g0872800 protein
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q8RUE8 633
organism: Oryza sativa

Oligophrenin-1
type: ProteinReference
xref: uniprot F7H3I5 1002
organism: Macaca mulatta

Mus musculus
type: BioSource
xref: ncbitaxon 10090 16

uniprot P20786 515
type: UnificationXref
id: P20786
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BD31 831
xref: PTHR45818:SF1
organism: Macaca mulatta

uniprot Q5F3R8 461
type: UnificationXref
id: Q5F3R8
db: uniprot

MEK
type: ProteinReference
xref: P01162
standard name: Mitogen-activated protein kinase kinase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 Synonym: MAPK/ERK KINASE 1,MAPKK1,MKK1,PROTEIN KINASE, MITOGEN-ACTIVATED, KINASE 1 Accession: P01162
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.MEK
member entity reference: Dual specificity mitogen-activated protein kinase kinase 1
member entity reference: Dual specificity mitogen-activated protein kinase kinase 2
member entity reference: Protein CBR-MEK-2
member entity reference: Dual specificity mitogen-activated protein kinase kinase mek-2
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase kinase 1
member entity reference: MAP2K1 protein
member entity reference: Dual-specificity mitogen-activated protein kinase kinase 2
member entity reference: MAP2K2 isoform 1
member entity reference: Dual specificity mitogen-activated protein kinase kinase dSOR1
member entity reference: Mitogen-activated protein kinase kinase 2

Rho GTPase-activating protein 10
type: ProteinReference
xref: uniprot A1A4S6 959
xref: PTHR12552:SF5
organism: Homo sapiens

uniprot P14921 704
type: UnificationXref
id: P14921
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P28482 153
xref: PTHR24055:SF203
organism: Homo sapiens

uniprot P28324 14
type: UnificationXref
id: P28324
db: uniprot

MAP kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot P49071 508
organism: Drosophila melanogaster

Platelet-derived growth factor receptor-like protein
type: ProteinReference
xref: uniprot Q6PE55 501
organism: Mus musculus

uniprot O08908 792
type: UnificationXref
id: O08908
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r37
controller: DAG

Ninein
type: ProteinReference
xref: uniprot A0A2I3T081 342
organism: Pan troglodytes

uniprot Q12236 630
type: UnificationXref
id: Q12236
db: uniprot

uniprot F7F5X1 419
type: UnificationXref
id: F7F5X1
db: uniprot

Mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot Q4QGB0 511
organism: Leishmania major

PTHR24356:SF322
type: RelationshipXref
id: PTHR24356:SF322
db: PANTHER Family
relationship type: By Homology

uniprot Q8IR23 339
type: UnificationXref
id: Q8IR23
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot Q8NEB9 818
organism: Homo sapiens

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F1Q118 521
xref: PTHR23113:SF168
organism: Canis lupus familiaris

uniprot Q15283 337
type: UnificationXref
id: Q15283
db: uniprot

c Jun s89 a141 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P27361 151
xref: PTHR24055:SF393
organism: Homo sapiens

Platelet-derived growth factor receptor-like protein
type: ProteinReference
xref: uniprot Q15198 499
organism: Homo sapiens

STATE_TRANSITION_LEFT__BAD-_ATP-RIGHT__BAD-_ADP-_r62
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 1183
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 1182
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 1184
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 1181
left: BAD
left: ATP
interaction type: STATE_TRANSITION
right: BAD
right: ADP

uniprot A0A1D5Q946 645
type: UnificationXref
id: A0A1D5Q946
db: uniprot

GRB2-associated-binding protein 2
type: ProteinReference
xref: uniprot Q9Z1S8 272
organism: Mus musculus

uniprot Q0VD16 610
type: UnificationXref
id: Q0VD16
db: uniprot

uniprot Q03407 629
type: UnificationXref
id: Q03407
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 192

GO GO:0005634 2
type: UnificationXref
id: GO:0005634
db: GO

uniprot Q04970 449
type: UnificationXref
id: Q04970
db: uniprot

uniprot A0A2I3TK00 576
type: UnificationXref
id: A0A2I3TK00
db: uniprot

uniprot A0A1D5PXC6 103
type: UnificationXref
id: A0A1D5PXC6
db: uniprot

ERK
type: Protein
entity reference: ERK
feature: ERK s97 a133 rs1
feature: ACTIVE 18
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot H9ENT4 67
xref: PTHR24351:SF48
organism: Macaca mulatta

uniprot E2RMC0 545
type: UnificationXref
id: E2RMC0
db: uniprot

uniprot P22981 443
type: UnificationXref
id: P22981
db: uniprot

Grb2
type: ProteinReference
xref: P01148
standard name: Growth factor receptor-bound protein 2
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.Grb2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: GRB2-related adaptor protein
member entity reference: Growth factor receptor-bound protein 2
member entity reference: GRB2-associated-binding protein 1
member entity reference: Uncharacterized protein
member entity reference: GRB2-associated-binding protein 2
member entity reference: Protein enhancer of sevenless 2B
member entity reference: GRB2-related adapter protein
member entity reference: Cytoplasmic protein
member entity reference: Protein CBR-SEM-5
member entity reference: Growth factor receptor-bound protein 2a
member entity reference: GAB2 isoform 1
member entity reference: GRB2 associated binding protein 1
member entity reference: GRB2 isoform 3
member entity reference: GAB1 isoform 1
member entity reference: AGAP011768-PA
member entity reference: GRB2-related adaptor protein 2
member entity reference: Sex muscle abnormal protein 5
member entity reference: GRB2-related adapter protein 2
member entity reference: GRAP2 isoform 1

uniprot E2RPJ2 119
type: UnificationXref
id: E2RPJ2
db: uniprot

uniprot H2QYA3 1013
type: UnificationXref
id: H2QYA3
db: uniprot

3-phosphoinositide dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot A0A2I3TN41 624
organism: Pan troglodytes

Ras-related and estrogen-regulated growth inhibitor
type: ProteinReference
xref: uniprot F7BP34 415
organism: Macaca mulatta

uniprot Q5F3W3 168
type: UnificationXref
id: Q5F3W3
db: uniprot

NRAS protein
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot A5D7R9 394
organism: Bos taurus

uniprot Q9QY78 234
type: UnificationXref
id: Q9QY78
db: uniprot

PTHR24351:SF213
type: RelationshipXref
id: PTHR24351:SF213
db: PANTHER Family
relationship type: By Homology

uniprot Q9Y2U5 188
type: UnificationXref
id: Q9Y2U5
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q01986 608
organism: Rattus norvegicus

PDGF receptor A
type: Protein
entity reference: PDGF receptor A
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa1 1086
feature: PDGF receptor A s3 sa1 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

MAPKAPK2
type: Protein
entity reference: MAPKAPK2
feature: MAPKAPK2 s82 a88 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF213
xref: uniprot F7FRY0 62
organism: Monodelphis domestica

Rho
type: Protein
entity reference: Rho
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A2I3TRE4 900
organism: Pan troglodytes

Ets s87 a137 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5PQJ2 952
organism: Gallus gallus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q9Z1L0 822
xref: PTHR10048:SF33
organism: Rattus norvegicus

GTPase NRas
type: ProteinReference
xref: uniprot P79737 448
xref: PTHR24070:SF189
organism: Danio rerio

uniprot P21708 150
type: UnificationXref
id: P21708
db: uniprot

uniprot C9J798 324
type: UnificationXref
id: C9J798
db: uniprot

uniprot F6XT65 602
type: UnificationXref
id: F6XT65
db: uniprot

Rho GTPase activating protein 5
type: ProteinReference
xref: uniprot F6Q8Z8 986
organism: Ornithorhynchus anatinus

uniprot F7ALW1 276
type: UnificationXref
id: F7ALW1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RasGAP-RIGHT__RasGAP-_r69
controller: Complex (PDGF receptor A/PDGF receptor B)

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot P09416 883
xref: PTHR45851:SF1
organism: Rattus norvegicus

ERK s97 a133 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GJA5 1000
organism: Macaca mulatta

PTHR19969:SF12
type: RelationshipXref
id: PTHR19969:SF12
db: PANTHER Family
relationship type: By Homology

uniprot A0A3Q2UBK0 31
type: UnificationXref
id: A0A3Q2UBK0
db: uniprot

PTHR10194:SF19
type: RelationshipXref
id: PTHR10194:SF19
db: PANTHER Family
relationship type: By Homology

PTHR19969:SF16
type: RelationshipXref
id: PTHR19969:SF16
db: PANTHER Family
relationship type: By Homology

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F1MQE1 46
xref: PTHR24351:SF41
organism: Bos taurus

Rho
type: Protein
entity reference: Rho
feature: ACTIVE 18
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot P23583 885
xref: PTHR45851:SF1
organism: Pan troglodytes

Ras protein let-60
type: ProteinReference
xref: uniprot P22981 443
xref: PTHR24070:SF420
organism: Caenorhabditis elegans

Raf s22 a66 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Oligophrenin-1
type: ProteinReference
xref: uniprot Q99J31 1057
organism: Mus musculus

ETS domain-containing protein Elk-1
type: ProteinReference
xref: uniprot P41969 17
xref: PTHR11849:SF178
organism: Mus musculus

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: uniprot Q4G050 291
xref: PTHR24349:SF114
organism: Rattus norvegicus

Ribosomal protein S6 kinase beta-2
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot Q9Z1M4 98
organism: Mus musculus

Protein CBR-ITR-1, isoform a
type: ProteinReference
xref: PTHR13715:SF87
xref: uniprot H8WGV2 555
organism: Caenorhabditis briggsae

Dual-specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot F1NYZ2 600
xref: PTHR48013:SF8
organism: Gallus gallus

uniprot Q9WV60 385
type: UnificationXref
id: Q9WV60
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GRE8 1001
organism: Macaca mulatta

uniprot F7H5F6 1003
type: UnificationXref
id: F7H5F6
db: uniprot

PTHR14166:SF6
type: RelationshipXref
id: PTHR14166:SF6
db: PANTHER Family
relationship type: By Homology

Rho GTPase-activating protein 27
type: ProteinReference
xref: uniprot Q6TLK4 1043
xref: PTHR23176:SF104
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RPB0 762
xref: PTHR10155:SF2
organism: Canis lupus familiaris

uniprot Q45FX5 838
type: UnificationXref
id: Q45FX5
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF43
xref: uniprot F7H7W3 63
organism: Macaca mulatta

uniprot E2QUM7 325
type: UnificationXref
id: E2QUM7
db: uniprot

Jak
type: ProteinReference
xref: P01155
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.Jak
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Jak Synonym: Janus kinase Accession: P01155
member entity reference: Tyrosine-protein kinase
member entity reference: Tyrosine-protein kinase JAK1
member entity reference: Tyrosine-protein kinase JAK3
member entity reference: Tyrosine-protein kinase JAK2

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RQ55 493
organism: Macaca mulatta

NRAS proto-oncogene, GTPase
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot F1PHV7 410
organism: Canis lupus familiaris

PDK1 2 s33 a96 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR24356:SF368
type: RelationshipXref
id: PTHR24356:SF368
db: PANTHER Family
relationship type: By Homology

Inhibitor of nuclear factor kappa B kinase subunit beta
type: ProteinReference
xref: uniprot E2RKR0 218
organism: Canis lupus familiaris

PTHR10194:SF3
type: RelationshipXref
id: PTHR10194:SF3
db: PANTHER Family
relationship type: By Homology

uniprot F6V946 581
type: UnificationXref
id: F6V946
db: uniprot

MEK s23 a69 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q2TY19 108
xref: PTHR24055:SF222
organism: Gallus gallus

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot F6T2X3 910
organism: Xenopus tropicalis

NRAS isoform 1
type: ProteinReference
xref: uniprot H2PZQ7 422
xref: PTHR24070:SF189
organism: Pan troglodytes

Ecdysone-induced protein 74EF isoform B
type: ProteinReference
xref: uniprot P11536 703
xref: PTHR11849:SF191
organism: Drosophila melanogaster

PTHR10194:SF4
type: RelationshipXref
id: PTHR10194:SF4
db: PANTHER Family
relationship type: By Homology

Rho GTPase-activating protein 27
type: ProteinReference
xref: uniprot A2AB59 960
xref: PTHR23176:SF104
organism: Mus musculus

uniprot A4GT58 961
type: UnificationXref
id: A4GT58
db: uniprot

PLCgamma
type: ProteinReference
xref: P01171
standard name: Phospholipase C, gamma
comment: ENTITY_REFERENCE_NOTES= Long Name: Phospholipase C, gamma Synonym: PLCG,PLCGamma,Phospholipase C-148 Accession: P01171
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.PLC_gamma_
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F7DUD6 778
organism: Ornithorhynchus anatinus

uniprot D4A208 971
type: UnificationXref
id: D4A208
db: uniprot

ARHGAP12 isoform 4
type: ProteinReference
xref: uniprot A0A2I3SG90 955
organism: Pan troglodytes

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot Q64143 814
organism: Mus musculus

uniprot Q62137 490
type: UnificationXref
id: Q62137
db: uniprot

StAR-related lipid transfer domain-containing 8
type: ProteinReference
xref: uniprot D4A5B9 972
xref: PTHR12659:SF3
organism: Rattus norvegicus

uniprot H2QIN7 143
type: UnificationXref
id: H2QIN7
db: uniprot

uniprot F1P8C2 982
type: UnificationXref
id: F1P8C2
db: uniprot

A-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot E2RL20 580
xref: PTHR44329:SF55
organism: Canis lupus familiaris

uniprot A5D7R9 394
type: UnificationXref
id: A5D7R9
db: uniprot

uniprot P26450 799
type: UnificationXref
id: P26450
db: uniprot

GRB2-associated-binding protein 1
type: ProteinReference
xref: uniprot A6QLU3 241
organism: Bos taurus

PTHR10194:SF21
type: RelationshipXref
id: PTHR10194:SF21
db: PANTHER Family
relationship type: By Homology

MAP kinase-interacting serine/threonine-protein kinase 2
type: ProteinReference
xref: uniprot Q9HBH9 297
xref: PTHR24349:SF254
organism: Homo sapiens

STATE_TRANSITION_LEFT__c_Jun-_ATP-RIGHT__c_Jun-_ADP-_r58
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1208
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1205
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1207
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1206
left: c-Jun
left: ATP
interaction type: STATE_TRANSITION
right: c-Jun
right: ADP

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q63844 174
organism: Mus musculus

uniprot O12990 484
type: UnificationXref
id: O12990
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12659:SF4
xref: uniprot F6RTT3 989
organism: Xenopus tropicalis

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A8XTZ1 861
organism: Caenorhabditis briggsae

Si:dkeyp-80c12.7
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot B8JIQ1 347
organism: Danio rerio

uniprot H2R9D6 1016
type: UnificationXref
id: H2R9D6
db: uniprot

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa5 1096
feature: ACTIVE 18
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot O08648 148
type: UnificationXref
id: O08648
db: uniprot

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: uniprot G3V926 223
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__PLCgamma-RIGHT__PLCgamma-_r36
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 1150
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 1149
left: PLCgamma
interaction type: STATE_TRANSITION
right: PLCgamma

uniprot Q8TD08 178
type: UnificationXref
id: Q8TD08
db: uniprot

uniprot O43295 1022
type: UnificationXref
id: O43295
db: uniprot

Shaggy-related protein kinase iota
type: ProteinReference
xref: uniprot Q39012 370
xref: PTHR24057:SF5
organism: Arabidopsis thaliana

uniprot Q21734 82
type: UnificationXref
id: Q21734
db: uniprot

Shaggy-related protein kinase eta
type: ProteinReference
xref: uniprot Q39011 369
xref: PTHR24057:SF42
organism: Arabidopsis thaliana

uniprot F7HLC7 784
type: UnificationXref
id: F7HLC7
db: uniprot

uniprot Q9LUC3 184
type: UnificationXref
id: Q9LUC3
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot A0A2I3SSC7 541
organism: Pan troglodytes

uniprot O00459 791
type: UnificationXref
id: O00459
db: uniprot

SLIT-ROBO Rho GTPase activating protein 3
type: ProteinReference
xref: uniprot H2R481 1015
organism: Pan troglodytes

uniprot P20033 852
type: UnificationXref
id: P20033
db: uniprot

uniprot A2AB59 960
type: UnificationXref
id: A2AB59
db: uniprot

uniprot Q9Z2B9 99
type: UnificationXref
id: Q9Z2B9
db: uniprot

uniprot Q92529 1080
type: UnificationXref
id: Q92529
db: uniprot

uniprot A0A3Q1LWJ8 107
type: UnificationXref
id: A0A3Q1LWJ8
db: uniprot

RHO GTPase-activating protein RGD1
type: ProteinReference
xref: uniprot P38339 1025
organism: Saccharomyces cerevisiae

uniprot H2QPH4 513
type: UnificationXref
id: H2QPH4
db: uniprot

SLIT-ROBO Rho GTPase-activating protein 2
type: ProteinReference
xref: uniprot D4A208 971
organism: Rattus norvegicus

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F7BWW9 525
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VTW2 995
xref: PTHR12552:SF5
organism: Macaca mulatta

uniprot A0A3Q1MK31 323
type: UnificationXref
id: A0A3Q1MK31
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__PDGF-_PDGF_receptor_B-_PDGF_receptor_A-RIGHT__Complex__PDGF_receptor_A_PDGF_receptor_B_-_r40
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 1139
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 1140
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 1138
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 1137
left: PDGF receptor B
left: PDGF receptor A
left: PDGF
interaction type: HETERODIMER_ASSOCIATION
right: Complex (PDGF receptor A/PDGF receptor B)

MODULATION
type: RelationshipTypeVocabulary

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF378
xref: uniprot Q39021 161
organism: Arabidopsis thaliana

uniprot O75676 71
type: UnificationXref
id: O75676
db: uniprot

Mitogen-activated protein kinase 2
type: ProteinReference
xref: PTHR24055:SF196
xref: uniprot Q39022 163
organism: Arabidopsis thaliana

PTHR46037:SF3
type: RelationshipXref
id: PTHR46037:SF3
db: PANTHER Family
relationship type: By Homology

uniprot P36507 607
type: UnificationXref
id: P36507
db: uniprot

PTHR46037:SF4
type: RelationshipXref
id: PTHR46037:SF4
db: PANTHER Family
relationship type: By Homology

GRB2-related adapter protein
type: ProteinReference
xref: PTHR46037:SF2
xref: uniprot Q13588 258
organism: Homo sapiens

00696
type: UnificationXref
id: MOD:00696
db: mod

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot Q62077 872
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YE27 684
xref: PTHR11849:SF206
organism: Macaca mulatta

uniprot E2QU99 669
type: UnificationXref
id: E2QU99
db: uniprot

ELK
type: Protein
entity reference: ELK
feature: ACTIVE 18
feature: ELK s31 a122 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot H2RA86 146
organism: Pan troglodytes

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot Q60631 262
xref: PTHR46037:SF4
organism: Mus musculus

Serum response factor
type: ProteinReference
xref: uniprot Q9JM73 216
xref: PTHR48019:SF40
organism: Mus musculus

PTHR46037:SF2
type: RelationshipXref
id: PTHR46037:SF2
db: PANTHER Family
relationship type: By Homology

SAM pointed domain containing ETS transcription factor
type: ProteinReference
xref: uniprot E2RGK1 672
xref: PTHR11849:SF182
organism: Canis lupus familiaris

PTHR46037:SF1
type: RelationshipXref
id: PTHR46037:SF1
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3RSY4 392
type: UnificationXref
id: A0A2I3RSY4
db: uniprot

c fos s96 a118 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot E2R3L5 670
type: UnificationXref
id: E2R3L5
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot G7MGQ5 785
organism: Macaca mulatta

PTHR24070:SF206
type: RelationshipXref
id: PTHR24070:SF206
db: PANTHER Family
relationship type: By Homology

uniprot P52160 886
type: UnificationXref
id: P52160
db: uniprot

uniprot A0A0R4IC22 569
type: UnificationXref
id: A0A0R4IC22
db: uniprot

TRANSPORT_LEFT__MAPKAPK2-RIGHT__MAPKAPK2-_r65
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 1166
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 1165
left: MAPKAPK2
interaction type: TRANSPORT
right: MAPKAPK2

uniprot A0A1D5Q3X8 21
type: UnificationXref
id: A0A1D5Q3X8
db: uniprot

STATE_TRANSITION_LEFT__ELK-_ATP-RIGHT__ELK-_ADP-_r46
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 1128
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 1129
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 1130
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 1127
left: ELK
left: ATP
interaction type: STATE_TRANSITION
right: ELK
right: ADP

uniprot A0A140T878 894
type: UnificationXref
id: A0A140T878
db: uniprot

ETS variant 3
type: ProteinReference
xref: PTHR11849:SF30
xref: uniprot A0A3Q1NFR3 656
organism: Bos taurus

uniprot F6RHV4 988
type: UnificationXref
id: F6RHV4
db: uniprot

VAV2 isoform 2
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot A0A2I3T4A4 824
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G4D2 204
xref: PTHR48019:SF40
organism: Macaca mulatta

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF213
xref: uniprot A0A3Q2UBK0 31
organism: Gallus gallus

uniprot F0ZB76 403
type: UnificationXref
id: F0ZB76
db: uniprot

uniprot A7F3M0 111
type: UnificationXref
id: A7F3M0
db: uniprot

Raf s22 a65 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

DISSOCIATION
type: RelationshipTypeVocabulary

Evidence 266
type: Evidence
evidence code: ISS
comment: Website http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd

Protein kinase gsk3
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot V5ILY7 389
organism: Neurospora crassa

uniprot Q24151 938
type: UnificationXref
id: Q24151
db: uniprot

eco ECO:0000250 7
type: UnificationXref
id: ECO:0000250
db: eco

Transcriptional regulator ERG
type: ProteinReference
xref: PTHR11849:SF216
xref: uniprot P81270 716
organism: Mus musculus

uniprot F1QWX2 908
type: UnificationXref
id: F1QWX2
db: uniprot

uniprot Q24806 454
type: UnificationXref
id: Q24806
db: uniprot

Platelet derived growth factor receptor like
type: ProteinReference
xref: uniprot H2QVT0 495
organism: Pan troglodytes

uniprot P04049 584
type: UnificationXref
id: P04049
db: uniprot

PTHR24356:SF390
type: RelationshipXref
id: PTHR24356:SF390
db: PANTHER Family
relationship type: By Homology

By Homology
type: RelationshipTypeVocabulary

PTHR44329:SF55
type: RelationshipXref
id: PTHR44329:SF55
db: PANTHER Family
relationship type: By Homology

uniprot Q9JHC9 739
type: UnificationXref
id: Q9JHC9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__c_Myc-_ATP-RIGHT__c_Myc-_ADP-_r48
controller: ERK

MAP3K2 isoform 1
type: ProteinReference
xref: uniprot H2QIN7 143
organism: Pan troglodytes

ERF isoform 1
type: ProteinReference
xref: PTHR11849:SF31
xref: uniprot H2R3U4 695
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot F6XT65 602
organism: Monodelphis domestica

uniprot Q8VDK3 734
type: UnificationXref
id: Q8VDK3
db: uniprot

uniprot H2PZC4 302
type: UnificationXref
id: H2PZC4
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot E2R7K9 40
xref: PTHR24351:SF171
organism: Canis lupus familiaris

uniprot F6V2V1 56
type: UnificationXref
id: F6V2V1
db: uniprot

uniprot A0A3Q1M864 238
type: UnificationXref
id: A0A3Q1M864
db: uniprot

PTHR44329:SF47
type: RelationshipXref
id: PTHR44329:SF47
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__mTOR-_ATP-RIGHT__mTOR-_ADP-_r63
controller: PKB

uniprot H2QLZ4 553
type: UnificationXref
id: H2QLZ4
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A4FV00 109
organism: Bos taurus

Glycogen synthase kinase 3 alpha
type: ProteinReference
xref: uniprot Q9YH61 388
xref: PTHR24057:SF14
organism: Danio rerio

Ras-like protein
type: ProteinReference
xref: PTHR24070:SF17
xref: uniprot Q12526 451
organism: Emericella nidulans

Glycogen synthase kinase 3
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot Q9YH60 387
organism: Danio rerio

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKB-RIGHT__PKB-_Pi-_r34
controller: CTMP

PI3K
type: ProteinReference
xref: P01168
standard name: Phosphatidylinositol 3-kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.PI3K
comment: ENTITY_REFERENCE_NOTES= Long Name: PHOSPHATIDYLINOSITOL 3-KINASE, CATALYTIC, ALPHA Synonym: Synonym not specified Accession: P01168
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol 3-kinase catalytic subunit type 3
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit gamma
member entity reference: Phosphoinositide 3-kinase regulatory subunit 5
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
member entity reference: Phosphatidylinositol 3-kinase 1
member entity reference: Phosphoinositide-3-kinase regulatory subunit 3
member entity reference: Phosphoinositide-3-kinase regulatory subunit 2
member entity reference: Phosphoinositide-3-kinase regulatory subunit 1
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit beta
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: PIK3CG isoform 1
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha
member entity reference: PI-3 kinase
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
member entity reference: PIK3R5 isoform 2
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
member entity reference: PIK3R1 isoform 1
member entity reference: Phosphatidylinositol 3-kinase VPS34
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
member entity reference: Phosphatidylinositol 3-kinase VPS34-like
member entity reference: Phosphatidylinositol 3-kinase 2
member entity reference: AGAP000018-PA
member entity reference: Phosphatidylinositol 3-kinase 3

Evidence 288
type: Evidence
evidence code: ISS
comment: SPACC Q9BUB5

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7CYE3 135
organism: Xenopus tropicalis

Rho GTPase activating protein 26
type: ProteinReference
xref: PTHR12552:SF4
xref: uniprot F6TVC2 992
organism: Monodelphis domestica

uniprot Q9V3C8 1082
type: UnificationXref
id: Q9V3C8
db: uniprot

uniprot H2QNG6 788
type: UnificationXref
id: H2QNG6
db: uniprot

MAPKAPK2
type: Protein
entity reference: MAPKAPK2
feature: MAPKAPK2 s93 a120 rs1
feature: ACTIVE 18
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Ras-like protein 1
type: ProteinReference
xref: uniprot Q59XU5 459
xref: PTHR24070:SF17
organism: Candida albicans

uniprot P51692 931
type: UnificationXref
id: P51692
db: uniprot

Growth factor receptor-bound protein 2a
type: ProteinReference
xref: uniprot Q5RKN6 261
xref: PTHR46037:SF4
organism: Danio rerio

uniprot F7BTH1 494
type: UnificationXref
id: F7BTH1
db: uniprot

Inhibitor of nuclear factor kappa B kinase subunit beta
type: ProteinReference
xref: uniprot H2QW34 224
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot O17788 426
organism: Caenorhabditis elegans

uniprot Q05030 498
type: UnificationXref
id: Q05030
db: uniprot

uniprot F1M7N7 45
type: UnificationXref
id: F1M7N7
db: uniprot

uniprot F1N1U5 674
type: UnificationXref
id: F1N1U5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot O17789 427
organism: Caenorhabditis elegans

uniprot H2QSV0 693
type: UnificationXref
id: H2QSV0
db: uniprot

PTHR10155:SF3
type: RelationshipXref
id: PTHR10155:SF3
db: PANTHER Family
relationship type: By Homology

uniprot F6PR50 125
type: UnificationXref
id: F6PR50
db: uniprot

uniprot Q923Q2 1056
type: UnificationXref
id: Q923Q2
db: uniprot

uniprot E2RR13 44
type: UnificationXref
id: E2RR13
db: uniprot

Serum response factor
type: ProteinReference
xref: uniprot E1BJP4 198
xref: PTHR48019:SF40
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF356
xref: uniprot E2RPJ2 119
organism: Canis lupus familiaris

uniprot F7D2D3 917
type: UnificationXref
id: F7D2D3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11849:SF161
xref: uniprot A0A1D5PED3 644
organism: Gallus gallus

PTHR10155:SF2
type: RelationshipXref
id: PTHR10155:SF2
db: PANTHER Family
relationship type: By Homology

PTHR10155:SF1
type: RelationshipXref
id: PTHR10155:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q9UK32 93
type: UnificationXref
id: Q9UK32
db: uniprot

uniprot Q9BRR9 1058
type: UnificationXref
id: Q9BRR9
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot H2QDQ1 303
organism: Pan troglodytes

uniprot E2RNA9 219
type: UnificationXref
id: E2RNA9
db: uniprot

RasGAP-activating-like protein 1
type: ProteinReference
xref: PTHR10194:SF3
xref: uniprot Q9Z268 340
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r50 1234
type: Stoichiometry
physical entity: c-fos
stoichiometric coefficient: 1.0

uniprot Q60775 731
type: UnificationXref
id: Q60775
db: uniprot

PARTICIPANT STOICHIOMETRY r50 1235
type: Stoichiometry
physical entity: c-fos
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A140T878 894
xref: PTHR11801:SF39
organism: Bos taurus

uniprot E1BBD2 827
type: UnificationXref
id: E1BBD2
db: uniprot

PTHR44329:SF22
type: RelationshipXref
id: PTHR44329:SF22
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 1225
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 1224
left: Raf
interaction type: STATE_TRANSITION
right: Raf

Uncharacterized protein
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot F7HPR8 1068
organism: Macaca mulatta

uniprot F7G8G5 918
type: UnificationXref
id: F7G8G5
db: uniprot

uniprot Q13588 258
type: UnificationXref
id: Q13588
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P19174 870
organism: Homo sapiens

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__IP3_receptor-RIGHT__IP3_receptor-_r82
controller: IP3

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot A0A1D5QE27 746
organism: Macaca mulatta

uniprot F6VXG1 772
type: UnificationXref
id: F6VXG1
db: uniprot

Uncharacterized protein rasD
type: ProteinReference
xref: uniprot F0ZB76 403
xref: PTHR24070:SF418
organism: Dictyostelium purpureum

RAB11B, member RAS oncogene family, a
type: ProteinReference
xref: uniprot Q1LVZ0 453
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r80 1102
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot K7BJ65 698
type: UnificationXref
id: K7BJ65
db: uniprot

uniprot O55173 627
type: UnificationXref
id: O55173
db: uniprot

PARTICIPANT STOICHIOMETRY r80 1101
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r80 1104
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot O95163 228
type: UnificationXref
id: O95163
db: uniprot

PARTICIPANT STOICHIOMETRY r80 1103
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

SOS
type: Protein
entity reference: SOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa7 1100
feature: ACTIVE 18
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ARHGAP26 isoform 1
type: ProteinReference
xref: PTHR12552:SF4
xref: uniprot H2QRP5 1012
organism: Pan troglodytes

uniprot A0A0R4IKK9 101
type: UnificationXref
id: A0A0R4IKK9
db: uniprot

PARTICIPANT STOICHIOMETRY r4 1124
type: Stoichiometry
physical entity: Complex (PDGF receptor A/PDGF receptor B)
stoichiometric coefficient: 1.0

SLIT-ROBO Rho GTPase-activating protein 3
type: ProteinReference
xref: uniprot F1M5M9 978
organism: Rattus norvegicus

Mitogen-activated protein kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot F6PX17 505
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r4 1123
type: Stoichiometry
physical entity: Complex (PDGF receptor A/PDGF receptor B)
stoichiometric coefficient: 1.0

uniprot P27361 151
type: UnificationXref
id: P27361
db: uniprot

ARHGAP15 isoform 2
type: ProteinReference
xref: uniprot H2QIS7 1011
xref: PTHR23176:SF108
organism: Pan troglodytes

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A0G2K5T3 745
organism: Rattus norvegicus

uniprot P11831 210
type: UnificationXref
id: P11831
db: uniprot

c Jun s90 a140 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q8IWW6 1052
type: UnificationXref
id: Q8IWW6
db: uniprot

uniprot P91634 811
type: UnificationXref
id: P91634
db: uniprot

Phosphoinositide-3-kinase regulatory subunit 1
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot F6Z0J4 775
organism: Xenopus tropicalis

uniprot F7E124 687
type: UnificationXref
id: F7E124
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot K7DH81 69
xref: PTHR24351:SF115
organism: Pan troglodytes

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7EI48 138
xref: PTHR24055:SF393
organism: Monodelphis domestica

Protein CBR-RGA-1
type: ProteinReference
xref: uniprot A8WTA3 964
organism: Caenorhabditis briggsae

uniprot A0A0G2K3R1 100
type: UnificationXref
id: A0A0G2K3R1
db: uniprot

c Myc s86 a125 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r25 1210
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

Cytoplasmic protein NCK2
type: ProteinReference
xref: uniprot O55033 282
xref: PTHR19969:SF12
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r25 1211
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r25 1212
type: Stoichiometry
physical entity: Complex (Grb2/Shc/ SOS)
stoichiometric coefficient: 1.0

uniprot A0A2I3SJJ2 649
type: UnificationXref
id: A0A2I3SJJ2
db: uniprot

uniprot F7DKS0 480
type: UnificationXref
id: F7DKS0
db: uniprot

Rho GTPase Activating protein
type: ProteinReference
xref: uniprot O01443 1020
organism: Caenorhabditis elegans

uniprot P23583 885
type: UnificationXref
id: P23583
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

uniprot Q58DT0 728
type: UnificationXref
id: Q58DT0
db: uniprot

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 112

AGAP006475-PA
type: ProteinReference
xref: uniprot Q5TQX0 565
xref: PTHR13715:SF87
organism: Anopheles gambiae

uniprot O43182 1021
type: UnificationXref
id: O43182
db: uniprot

STAT s20 a52 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Phosphoinositide-3-kinase regulatory subunit 5
type: ProteinReference
xref: uniprot E2RLD1 761
xref: PTHR15593:SF2
organism: Canis lupus familiaris

uniprot Q63844 174
type: UnificationXref
id: Q63844
db: uniprot

Ras-like protein rasB
type: ProteinReference
xref: uniprot P32252 444
xref: PTHR24070:SF206
organism: Dictyostelium discoideum

Vav guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot E2RGT8 828
xref: PTHR45818:SF2
organism: Canis lupus familiaris

AGAP000018-PA
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot Q7QEJ7 816
organism: Anopheles gambiae

Ras-like protein rasS
type: ProteinReference
xref: PTHR24070:SF380
xref: uniprot P32254 446
organism: Dictyostelium discoideum

Ras-like protein rasC
type: ProteinReference
xref: uniprot P32253 445
xref: PTHR24070:SF251
organism: Dictyostelium discoideum

uniprot H2QF58 833
type: UnificationXref
id: H2QF58
db: uniprot

PARTICIPANT STOICHIOMETRY r34 1158
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r34 1157
type: Stoichiometry
physical entity: PKB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r34 1156
type: Stoichiometry
physical entity: PKB
stoichiometric coefficient: 1.0

PTHR11849:SF203
type: RelationshipXref
id: PTHR11849:SF203
db: PANTHER Family
relationship type: By Homology

PTHR11849:SF204
type: RelationshipXref
id: PTHR11849:SF204
db: PANTHER Family
relationship type: By Homology

Proto-oncogene vav
type: ProteinReference
xref: uniprot P27870 836
xref: PTHR45818:SF2
organism: Mus musculus

Signal transducer and activator of transcription 5B
type: ProteinReference
xref: uniprot P51692 931
xref: PTHR11801:SF39
organism: Homo sapiens

PTHR24055:SF491
type: RelationshipXref
id: PTHR24055:SF491
db: PANTHER Family
relationship type: By Homology

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: uniprot O08605 290
xref: PTHR24349:SF114
organism: Mus musculus

uniprot A0A2I3RH39 747
type: UnificationXref
id: A0A2I3RH39
db: uniprot

uniprot F6TAH0 864
type: UnificationXref
id: F6TAH0
db: uniprot

uniprot A0A452DJ80 875
type: UnificationXref
id: A0A452DJ80
db: uniprot

ncbitaxon 8364 49
type: UnificationXref
id: 8364
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r25 1209
type: Stoichiometry
physical entity: Shc
stoichiometric coefficient: 1.0

GO GO:0005737 4
type: UnificationXref
id: GO:0005737
db: GO

Phosphatidylinositol 3-kinase VPS34
type: ProteinReference
xref: uniprot P22543 796
xref: PTHR10048:SF7
organism: Saccharomyces cerevisiae

PTHR11849:SF216
type: RelationshipXref
id: PTHR11849:SF216
db: PANTHER Family
relationship type: By Homology

MAPKAPK2 s93 a120 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Mitogen-activated protein kinase 16
type: ProteinReference
xref: uniprot Q8W4J2 179
organism: Arabidopsis thaliana

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot E1BMX0 400
organism: Bos taurus

uniprot Q63744 1040
type: UnificationXref
id: Q63744
db: uniprot

SHC-transforming protein 3
type: ProteinReference
xref: PTHR10337:SF4
xref: uniprot Q92529 1080
organism: Homo sapiens

PTHR23176:SF113
type: RelationshipXref
id: PTHR23176:SF113
db: PANTHER Family
relationship type: By Homology

ATP
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2QD19 919
type: UnificationXref
id: H2QD19
db: uniprot

Protein CBR-SRGP-1
type: ProteinReference
xref: uniprot A8X0U6 965
organism: Caenorhabditis briggsae

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 455

STAT
type: Protein
entity reference: STAT
feature: ACTIVE 18
feature: STAT s20 a52 rs1
feature: STAT s20 a52 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 7

c-Myc
type: Protein
entity reference: c-Myc
feature: c Myc s86 a125 rs1
feature: ACTIVE 18
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

E74 like ETS transcription factor 1
type: ProteinReference
xref: PTHR11849:SF156
xref: uniprot A0A2I3TEC2 651
organism: Pan troglodytes

uniprot E2RB53 348
type: UnificationXref
id: E2RB53
db: uniprot

uniprot Q02750 609
type: UnificationXref
id: Q02750
db: uniprot

uniprot A0A3Q1M614 502
type: UnificationXref
id: A0A3Q1M614
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTP-_Ras-RIGHT__GDP-_Ras-_r20
controller: Nck

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot O14920 225
organism: Homo sapiens

uniprot F6VQP7 550
type: UnificationXref
id: F6VQP7
db: uniprot

PDGF
type: ProteinReference
xref: P01170
standard name: Platelet-Derived Growth Factor
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.PDGF
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: PDGF Synonym: Platelet-derived growth factor Accession: P01170
member entity reference: Uncharacterized protein
member entity reference: Platelet-derived growth factor subunit A
member entity reference: PDGFB protein
member entity reference: Platelet-derived growth factor subunit B
member entity reference: Platelet-derived growth factor A chain long form
member entity reference: PDGFB isoform 1
member entity reference: Platelet-derived growth factor alpha polypeptide a

PTHR11849:SF209
type: RelationshipXref
id: PTHR11849:SF209
db: PANTHER Family
relationship type: By Homology

uniprot Q7QDB4 86
type: UnificationXref
id: Q7QDB4
db: uniprot

PTHR11849:SF206
type: RelationshipXref
id: PTHR11849:SF206
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Ets-RIGHT__Ets-_ADP-_r49
controller: ERK

uniprot F6VDE6 244
type: UnificationXref
id: F6VDE6
db: uniprot

uniprot P08487 867
type: UnificationXref
id: P08487
db: uniprot

uniprot O08605 290
type: UnificationXref
id: O08605
db: uniprot

PTHR23176:SF103
type: RelationshipXref
id: PTHR23176:SF103
db: PANTHER Family
relationship type: By Homology

PTHR23176:SF104
type: RelationshipXref
id: PTHR23176:SF104
db: PANTHER Family
relationship type: By Homology

c-fos
type: ProteinReference
xref: P01145
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.c-fos
comment: ENTITY_REFERENCE_NOTES= Long Name: c-fos Synonym: Cellular oncogene fos,Proto-oncogene protein c-fos Accession: P01145
member entity reference: Proto-oncogene c-Fos
member entity reference: Serum response factor
member entity reference: C-fos
member entity reference: Upstream stimulatory factor 2
member entity reference: Upstream stimulatory factor 2 isoform 1
member entity reference: SRF isoform 1
member entity reference: Upstream transcription factor 2, c-fos interacting
member entity reference: Uncharacterized protein
member entity reference: V-fos FBJ murine osteosarcoma viral oncogene homolog
member entity reference: Fos proto-oncogene, AP-1 transcription factor subunit
member entity reference: FBJ murine osteosarcoma viral oncogene homolog

uniprot F6Y4G8 130
type: UnificationXref
id: F6Y4G8
db: uniprot

Protein ras-1
type: ProteinReference
xref: PTHR24070:SF17
xref: uniprot P22126 442
organism: Neurospora crassa

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 58

uniprot G7N7I9 1007
type: UnificationXref
id: G7N7I9
db: uniprot

uniprot P16885 869
type: UnificationXref
id: P16885
db: uniprot

uniprot A7F871 395
type: UnificationXref
id: A7F871
db: uniprot

uniprot O08874 304
type: UnificationXref
id: O08874
db: uniprot

uniprot A0A3Q2UD13 543
type: UnificationXref
id: A0A3Q2UD13
db: uniprot

Vav
type: ProteinReference
xref: P01169
standard name: Guanine nucleotide exchange factor VAV
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.Vav
comment: ENTITY_REFERENCE_NOTES= Long Name: Vav Synonym: family of guanine nucleotide exchange factors for Rho family GTPases Accession: P01169
member entity reference: Guanine nucleotide exchange factor VAV3
member entity reference: Guanine nucleotide exchange factor VAV2
member entity reference: Vav guanine nucleotide exchange factor 1
member entity reference: AGAP010292-PA (Fragment)
member entity reference: Protein vav-1
member entity reference: Protein vav
member entity reference: Proto-oncogene vav
member entity reference: Vav guanine nucleotide exchange factor 3
member entity reference: Vav guanine nucleotide exchange factor 2
member entity reference: Uncharacterized protein
member entity reference: VAV1 isoform 2
member entity reference: Guanine nucleotide exchange factor VAV2 isoform 1
member entity reference: VAV2 isoform 2

uniprot O75791 251
type: UnificationXref
id: O75791
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HHG8 1005
organism: Macaca mulatta

uniprot F6RA79 300
type: UnificationXref
id: F6RA79
db: uniprot

Ribosomal protein S6 kinase alpha-6
type: ProteinReference
xref: uniprot Q9UK32 93
xref: PTHR24351:SF98
organism: Homo sapiens

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot O15530 626
organism: Homo sapiens

PTHR23176:SF108
type: RelationshipXref
id: PTHR23176:SF108
db: PANTHER Family
relationship type: By Homology

uniprot P52632 934
type: UnificationXref
id: P52632
db: uniprot

GRB2-related adaptor protein 2
type: ProteinReference
xref: uniprot O89100 252
xref: PTHR46037:SF3
organism: Mus musculus

GA repeat binding protein, alpha (Predicted)
type: ProteinReference
xref: uniprot D4ACQ9 668
xref: PTHR11849:SF195
organism: Rattus norvegicus

Os10g0521700 protein
type: ProteinReference
xref: PTHR24057:SF60
xref: uniprot Q8LNI5 372
organism: Oryza sativa

uniprot Q9R0C8 842
type: UnificationXref
id: Q9R0C8
db: uniprot

uniprot P11536 703
type: UnificationXref
id: P11536
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6ZKB3 132
xref: PTHR24055:SF222
organism: Macaca mulatta

PIP2
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F7G3I5 782
organism: Monodelphis domestica

uniprot F7EP57 779
type: UnificationXref
id: F7EP57
db: uniprot

uniprot F6YLX1 479
type: UnificationXref
id: F6YLX1
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot F6R543 548
organism: Monodelphis domestica

SHC (Src homology 2 domain containing) transforming protein 1
type: ProteinReference
xref: uniprot H2R8L2 1069
xref: PTHR10337:SF2
organism: Pan troglodytes

uniprot F6VHF7 549
type: UnificationXref
id: F6VHF7
db: uniprot

Protein CBR-RAS-1
type: ProteinReference
xref: uniprot A8XZ02 399
organism: Caenorhabditis briggsae

ETS transcription factor ERG
type: ProteinReference
xref: uniprot F1PHH8 676
xref: PTHR11849:SF216
organism: Canis lupus familiaris

uniprot Q8VZD5 374
type: UnificationXref
id: Q8VZD5
db: uniprot

uniprot A0A2I3T081 342
type: UnificationXref
id: A0A2I3T081
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF356
xref: uniprot F6WBW6 129
organism: Macaca mulatta

MNK1/2
type: Protein
entity reference: MNK1/2
feature: MNK1 2 s81 a80 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q15198 499
type: UnificationXref
id: Q15198
db: uniprot

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot A0A3Q1M353 577
xref: PTHR44329:SF47
organism: Bos taurus

Protein CBR-LET-60
type: ProteinReference
xref: uniprot A8X0X5 398
xref: PTHR24070:SF420
organism: Caenorhabditis briggsae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__STAT-_ATP-RIGHT__STAT-_ADP-_r80
controller: ERK

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot O08648 148
organism: Mus musculus

uniprot A2T737 657
type: UnificationXref
id: A2T737
db: uniprot

GRAP2 isoform 1
type: ProteinReference
xref: uniprot A0A2J8LNE4 237
xref: PTHR46037:SF3
organism: Pan troglodytes

Inositol 1,4,5-trisphosphate receptor itr-1
type: ProteinReference
xref: uniprot Q9Y0A1 567
xref: PTHR13715:SF87
organism: Caenorhabditis elegans

Platelet-derived growth factor alpha polypeptide a
type: ProteinReference
xref: uniprot A5PMP7 844
organism: Danio rerio

c-Jun
type: Protein
entity reference: c-Jun
feature: c Jun s89 a141 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F7AH39 998
type: UnificationXref
id: F7AH39
db: uniprot

uniprot P31938 605
type: UnificationXref
id: P31938
db: uniprot

uniprot Q9NZC4 740
type: UnificationXref
id: Q9NZC4
db: uniprot

uniprot Q5F3U4 632
type: UnificationXref
id: Q5F3U4
db: uniprot

uniprot K7BYT0 604
type: UnificationXref
id: K7BYT0
db: uniprot

uniprot A0A1D5Q4Y8 953
type: UnificationXref
id: A0A1D5Q4Y8
db: uniprot

uniprot P78545 715
type: UnificationXref
id: P78545
db: uniprot

PARTICIPANT STOICHIOMETRY r33 1164
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r33 1163
type: Stoichiometry
physical entity: Ikk
stoichiometric coefficient: 1.0

STAT s123 a173 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

Putative ribosomal protein S6 kinase alpha-1
type: ProteinReference
xref: PTHR24351:SF110
xref: uniprot Q21734 82
organism: Caenorhabditis elegans

IP3 receptor
type: Protein
entity reference: IP3 receptor
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r29
controller: Complex (PDGF receptor A/PDGF receptor B)

Ribosomal protein S6 kinase alpha-5
type: ProteinReference
xref: uniprot O75582 70
xref: PTHR24351:SF115
organism: Homo sapiens

uniprot Q9Z329 568
type: UnificationXref
id: Q9Z329
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot Q92569 820
organism: Homo sapiens

uniprot F1M2G3 409
type: UnificationXref
id: F1M2G3
db: uniprot

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 573
evidence: Evidence 574
evidence: Evidence 571
evidence: Evidence 572
xref: uniprot A0A2I3THL4 575
xref: PTHR44329:SF22
organism: Pan troglodytes

uniprot E2REI6 579
type: UnificationXref
id: E2REI6
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 162

PARTICIPANT STOICHIOMETRY r33 1162
type: Stoichiometry
physical entity: Ikk
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r33 1161
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot A0A3Q1LS58 655
type: UnificationXref
id: A0A3Q1LS58
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot A0A3Q1NH21 313
organism: Bos taurus

uniprot D3ZSB7 35
type: UnificationXref
id: D3ZSB7
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7GAP5 783
xref: PTHR10048:SF33
organism: Ornithorhynchus anatinus

uniprot P41156 709
type: UnificationXref
id: P41156
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P21708 150
organism: Rattus norvegicus

uniprot Q13164 159
type: UnificationXref
id: Q13164
db: uniprot

uniprot O89100 252
type: UnificationXref
id: O89100
db: uniprot

uniprot F7HPR8 1068
type: UnificationXref
id: F7HPR8
db: uniprot

uniprot A0A3Q1LJJ3 654
type: UnificationXref
id: A0A3Q1LJJ3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot A0A1D5NVQ5 823
organism: Gallus gallus

GA-binding protein alpha chain
type: ProteinReference
xref: PTHR11849:SF292
xref: uniprot Q06546 720
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Vav-RIGHT__Vav-_r73
controller: Complex (PDGF receptor A/PDGF receptor B)

Inositol 1,4,5-trisphosphate receptor
type: ProteinReference
xref: PTHR13715:SF87
xref: uniprot P29993 558
organism: Drosophila melanogaster

Ras
type: ProteinReference
xref: P01154
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Ras Synonym: Synonym not specified Accession: P01154
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.Ras
member entity reference: GTPase NRas
member entity reference: Uncharacterized protein
member entity reference: RAS-like, estrogen-regulated, growth-inhibitor
member entity reference: Ras-related and estrogen-regulated growth inhibitor
member entity reference: NRAS isoform 1
member entity reference: Uncharacterized protein rasS
member entity reference: Ras-like protein 1
member entity reference: Ras protein let-60
member entity reference: Ras family GTPase
member entity reference: AGAP002219-PA
member entity reference: RAB11B, member RAS oncogene family, a
member entity reference: Uncharacterized protein rasC
member entity reference: RAB11B, member RAS oncogene family
member entity reference: RAB11B, member RAS oncogene family, gene 1
member entity reference: GTPase KRas
member entity reference: Ras-like protein 2
member entity reference: Ras-related protein Rab-11B
member entity reference: Predicted protein
member entity reference: NRAS proto-oncogene, GTPase
member entity reference: Harvey rat sarcoma viral oncogene homolog
member entity reference: Ras-like protein rasG
member entity reference: GTPase HRas
member entity reference: GTP binding protein
member entity reference: GTP-binding protein
member entity reference: Ras-like protein rasC
member entity reference: Uncharacterized protein rasB
member entity reference: HRAS isoform 2
member entity reference: HRas proto-oncogene, GTPase a
member entity reference: GTPase HRas isoform 1
member entity reference: Uncharacterized protein rasG
member entity reference: Ras-like protein rasB
member entity reference: RAB11B, member RAS oncogene family, b
member entity reference: RAS like estrogen regulated growth inhibitor
member entity reference: RAB11B, member RAS oncogene family, gene 2
member entity reference: Ras-like protein
member entity reference: Ras homolog family member B
member entity reference: -Ha-ras Harvey rat sarcoma viral oncogene homolog, like
member entity reference: Protein ras-1
member entity reference: Protein CBR-RAS-1
member entity reference: Uncharacterized protein rasD
member entity reference: Ras-like protein rasS
member entity reference: Ras-like protein rasD
member entity reference: NRAS protein
member entity reference: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
member entity reference: Protein CBR-LET-60

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F1P4J0 47
xref: PTHR24351:SF48
organism: Gallus gallus

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot P29995 560
xref: PTHR13715:SF53
organism: Rattus norvegicus

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot P29994 559
organism: Rattus norvegicus

GTPase-activating protein
type: ProteinReference
xref: PTHR10194:SF126
xref: uniprot P48423 335
organism: Drosophila melanogaster

uniprot F7GAP5 783
type: UnificationXref
id: F7GAP5
db: uniprot

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot F6SHC1 220
organism: Macaca mulatta

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2RP04 43
xref: PTHR24351:SF58
organism: Canis lupus familiaris

Rho GTPase-activating protein 9
type: ProteinReference
xref: PTHR23176:SF103
xref: uniprot Q9BRR9 1058
organism: Homo sapiens

Ribosomal protein S6 kinase beta-2
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot Q9UBS0 92
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot O00329 790
organism: Homo sapiens

uniprot H2Q147 64
type: UnificationXref
id: H2Q147
db: uniprot

PTHR24070:SF251
type: RelationshipXref
id: PTHR24070:SF251
db: PANTHER Family
relationship type: By Homology

uniprot Q9VTU3 1062
type: UnificationXref
id: Q9VTU3
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 102

uniprot A0A3Q1M353 577
type: UnificationXref
id: A0A3Q1M353
db: uniprot

Serine/threonine-protein kinase PKH2
type: ProteinReference
xref: uniprot Q12236 630
xref: PTHR24356:SF368
organism: Saccharomyces cerevisiae

uniprot A8XZ02 399
type: UnificationXref
id: A8XZ02
db: uniprot

uniprot F7FP88 203
type: UnificationXref
id: F7FP88
db: uniprot

MAPKAPK2 s82 a88 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Uncharacterized protein
type: ProteinReference
xref: uniprot F7AKA6 133
organism: Monodelphis domestica

ETS domain-containing transcription factor ERF
type: ProteinReference
xref: PTHR11849:SF31
xref: uniprot P50548 712
organism: Homo sapiens

uniprot F6WHZ1 681
type: UnificationXref
id: F6WHZ1
db: uniprot

PARTICIPANT STOICHIOMETRY r20 1227
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QEF8 954
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r20 1226
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot Q9UQC2 271
type: UnificationXref
id: Q9UQC2
db: uniprot

PARTICIPANT STOICHIOMETRY r20 1229
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 1228
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot E1BKE7 544
organism: Bos taurus

Protein kinase gsk3
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot Q10452 367
organism: Schizosaccharomyces pombe

uniprot E2RGK1 672
type: UnificationXref
id: E2RGK1
db: uniprot

E74 like ETS transcription factor 5
type: ProteinReference
xref: PTHR11849:SF15
xref: uniprot H2Q3E6 692
organism: Pan troglodytes

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot D4A5Q1 756
organism: Rattus norvegicus

uniprot F7EJL2 832
type: UnificationXref
id: F7EJL2
db: uniprot

GRB2-related adapter protein
type: ProteinReference
xref: PTHR46037:SF2
xref: uniprot F7GJG7 246
organism: Macaca mulatta

Cytoplasmic protein
type: ProteinReference
xref: uniprot F1P4Q4 275
xref: PTHR19969:SF12
organism: Gallus gallus

uniprot A0A1D5QKD3 597
type: UnificationXref
id: A0A1D5QKD3
db: uniprot

PTHR24072:SF0
type: RelationshipXref
id: PTHR24072:SF0
db: PANTHER Family
relationship type: By Homology

Rho GTPase-activating protein 8
type: ProteinReference
xref: uniprot P85298 1027
organism: Homo sapiens

uniprot Q62120 489
type: UnificationXref
id: Q62120
db: uniprot

STATE_TRANSITION_LEFT__Complex__PDGF_receptor_A_PDGF_receptor_B_-RIGHT__Complex__PDGF_receptor_A_PDGF_receptor_B_-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1123
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1124
left: Complex (PDGF receptor A/PDGF receptor B)
interaction type: STATE_TRANSITION
right: Complex (PDGF receptor A/PDGF receptor B)

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot A0A2I3TRY9 750
xref: PTHR10048:SF7
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_Pi-_r24
controller: RasGAP

uniprot Q15723 722
type: UnificationXref
id: Q15723
db: uniprot

Serum response factor
type: ProteinReference
xref: uniprot D3ZHH8 197
xref: PTHR48019:SF40
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR10194:SF21
xref: uniprot F1N795 327
organism: Bos taurus

uniprot A0A3Q1NFR3 656
type: UnificationXref
id: A0A3Q1NFR3
db: uniprot

Protein enhancer of sevenless 2B
type: ProteinReference
xref: PTHR46037:SF1
xref: uniprot Q08012 256
organism: Drosophila melanogaster

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: uniprot P15056 591
xref: PTHR44329:SF47
organism: Homo sapiens

PTHR11849:SF289
type: RelationshipXref
id: PTHR11849:SF289
db: PANTHER Family
relationship type: By Homology

uniprot F1P4J0 47
type: UnificationXref
id: F1P4J0
db: uniprot

PTHR11849:SF287
type: RelationshipXref
id: PTHR11849:SF287
db: PANTHER Family
relationship type: By Homology

uniprot P40763 922
type: UnificationXref
id: P40763
db: uniprot

uniprot A5PKJ4 110
type: UnificationXref
id: A5PKJ4
db: uniprot

Complex (PDGF receptor A/PDGF receptor B)
type: Complex
component stoichiometry: PDGF receptor B s4 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: PDGF s128 a169 STOICHIOMETRY ID COMPLEX
component stoichiometry: PDGF receptor A s3 sa1 STOICHIOMETRY ID COMPLEX
component: PDGF
component: PDGF receptor B
component: PDGF receptor A
feature: COMPLEX BINDING FEATURE s7 a12 1083
feature: COMPLEX BINDING FEATURE s7 a12 1087
feature: COMPLEX BINDING FEATURE s7 a12 1085
cellular location: cytoplasm

PKN2 isoform 2
type: ProteinReference
xref: uniprot H2PZC4 302
xref: PTHR24356:SF322
organism: Pan troglodytes

uniprot Q5ZMW5 1039
type: UnificationXref
id: Q5ZMW5
db: uniprot

uniprot F7GJA5 1000
type: UnificationXref
id: F7GJA5
db: uniprot

MAP kinase-interacting serine/threonine-protein kinase 2
type: ProteinReference
xref: uniprot Q5U2N4 293
xref: PTHR24349:SF254
organism: Rattus norvegicus

PKB s104 a156 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

ncbitaxon 3702 162
type: UnificationXref
id: 3702
db: ncbitaxon

E74-like ETS transcription factor 2
type: ProteinReference
xref: uniprot Q5XIT5 729
xref: PTHR11849:SF10
organism: Rattus norvegicus

GA binding protein transcription factor subunit alpha
type: ProteinReference
xref: PTHR11849:SF195
xref: uniprot E2R3L5 670
organism: Canis lupus familiaris

RasGAP
type: Protein
entity reference: RasGAP
feature: ACTIVE 18
feature: RasGAP s107 a63 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot F7G8G5 918
organism: Macaca mulatta

uniprot Q5ZIF0 614
type: UnificationXref
id: Q5ZIF0
db: uniprot

PARTICIPANT STOICHIOMETRY r23 1216
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Ras-like protein rasG
type: ProteinReference
xref: PTHR24070:SF17
xref: uniprot P15064 441
organism: Dictyostelium discoideum

PARTICIPANT STOICHIOMETRY r23 1217
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

Protein B-Myc
type: ProteinReference
xref: PTHR45851:SF6
xref: uniprot P15063 884
organism: Rattus norvegicus

uniprot Q9Z2U4 743
type: UnificationXref
id: Q9Z2U4
db: uniprot

PARTICIPANT STOICHIOMETRY r23 1218
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

uniprot Q13480 257
type: UnificationXref
id: Q13480
db: uniprot

PARTICIPANT STOICHIOMETRY r23 1219
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot P63085 157
type: UnificationXref
id: P63085
db: uniprot

uniprot Q99J31 1057
type: UnificationXref
id: Q99J31
db: uniprot

Proline-rich protein 5
type: ProteinReference
xref: uniprot Q5FVG6 1036
organism: Rattus norvegicus

uniprot O70143 1071
type: UnificationXref
id: O70143
db: uniprot

uniprot Q64705 214
type: UnificationXref
id: Q64705
db: uniprot

uniprot P49841 364
type: UnificationXref
id: P49841
db: uniprot

PTHR11849:SF292
type: RelationshipXref
id: PTHR11849:SF292
db: PANTHER Family
relationship type: By Homology

RAB11B, member RAS oncogene family, b
type: ProteinReference
xref: uniprot Q6DGU2 463
organism: Danio rerio

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot F6YJ34 57
organism: Monodelphis domestica

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 6

uniprot F6R8N9 126
type: UnificationXref
id: F6R8N9
db: uniprot

uniprot F7BP34 415
type: UnificationXref
id: F7BP34
db: uniprot

RasGAP s45 a159 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Jak s112 a49 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.04
comment: MODIFICATION_RESIDUE_NAME=

Upstream transcription factor 2, c-fos interacting
type: ProteinReference
xref: uniprot A0A3Q1LR26 194
organism: Bos taurus

PLCgamma
type: Protein
entity reference: PLCgamma
feature: PLCgamma s18 a109 rs1
feature: ACTIVE 18
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A0A3Q1LR26 194
type: UnificationXref
id: A0A3Q1LR26
db: uniprot

uniprot A0A2I3TEC2 651
type: UnificationXref
id: A0A2I3TEC2
db: uniprot

uniprot F6UK84 53
type: UnificationXref
id: F6UK84
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot Q66II3 263
xref: PTHR46037:SF4
organism: Xenopus tropicalis

Protein CBR-SEM-5
type: ProteinReference
xref: PTHR46037:SF1
xref: uniprot A8XPY6 242
organism: Caenorhabditis briggsae

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot D3Z8E0 34
organism: Rattus norvegicus

Vav guanine nucleotide exchange factor 3
type: ProteinReference
xref: uniprot E1BBD2 827
xref: PTHR45818:SF1
organism: Bos taurus

uniprot A3R0S3 239
type: UnificationXref
id: A3R0S3
db: uniprot

SHC-transforming protein homolog 1
type: ProteinReference
xref: PTHR10337:SF11
xref: uniprot Q9TYT3 1081
organism: Caenorhabditis elegans

PTHR13168:SF2
type: RelationshipXref
id: PTHR13168:SF2
db: PANTHER Family
relationship type: By Homology

DNA-binding protein Ets97D
type: ProteinReference
xref: uniprot Q04688 719
xref: PTHR11849:SF195
organism: Drosophila melanogaster

PTHR13168:SF0
type: RelationshipXref
id: PTHR13168:SF0
db: PANTHER Family
relationship type: By Homology

PDGF
type: Protein
entity reference: PDGF
feature: COMPLEX PARTICIPANT BINDING FEATURE s129 a170 1090
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q63789 813
type: UnificationXref
id: Q63789
db: uniprot

ARHGAP1 isoform 3
type: ProteinReference
xref: uniprot H2Q3I0 1009
xref: PTHR45808:SF6
organism: Pan troglodytes

uniprot Q9NAH6 91
type: UnificationXref
id: Q9NAH6
db: uniprot

uniprot Q9NAD6 944
type: UnificationXref
id: Q9NAD6
db: uniprot

PTHR10048:SF34
type: RelationshipXref
id: PTHR10048:SF34
db: PANTHER Family
relationship type: By Homology

uniprot P0CQ42 439
type: UnificationXref
id: P0CQ42
db: uniprot

uniprot O88763 795
type: UnificationXref
id: O88763
db: uniprot

PTHR10048:SF33
type: RelationshipXref
id: PTHR10048:SF33
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF35
type: RelationshipXref
id: PTHR10048:SF35
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR10194:SF4
xref: uniprot A0A3Q1MK31 323
organism: Bos taurus

uniprot Q503B6 458
type: UnificationXref
id: Q503B6
db: uniprot

uniprot B1AUY3 966
type: UnificationXref
id: B1AUY3
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot F7HLC7 784
organism: Macaca mulatta

STATE_TRANSITION_LEFT__ATP-_PKB-RIGHT__PKB-_ADP-_r32
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 1167
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 1169
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 1168
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 1170
left: PKB
left: ATP
interaction type: STATE_TRANSITION
right: PKB
right: ADP

uniprot Q9Y6R4 189
type: UnificationXref
id: Q9Y6R4
db: uniprot

uniprot P29995 560
type: UnificationXref
id: P29995
db: uniprot

SLIT-ROBO Rho GTPase activating protein 1
type: ProteinReference
xref: uniprot F1P8C2 982
organism: Canis lupus familiaris

uniprot P26618 516
type: UnificationXref
id: P26618
db: uniprot

uniprot A0A2I3RG08 1066
type: UnificationXref
id: A0A2I3RG08
db: uniprot

uniprot F6T2X3 910
type: UnificationXref
id: F6T2X3
db: uniprot

uniprot P31751 317
type: UnificationXref
id: P31751
db: uniprot

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: uniprot O15111 226
organism: Homo sapiens

uniprot F7CW94 916
type: UnificationXref
id: F7CW94
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot E2RH85 759
organism: Canis lupus familiaris

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot A0A3Q1LQK4 753
organism: Bos taurus

PTHR24349:SF254
type: RelationshipXref
id: PTHR24349:SF254
db: PANTHER Family
relationship type: By Homology

uniprot E2RAB4 975
type: UnificationXref
id: E2RAB4
db: uniprot

uniprot H9FVU5 789
type: UnificationXref
id: H9FVU5
db: uniprot

uniprot K7CEN2 147
type: UnificationXref
id: K7CEN2
db: uniprot

PTHR10048:SF48
type: RelationshipXref
id: PTHR10048:SF48
db: PANTHER Family
relationship type: By Homology

FLI1 isoform 1
type: ProteinReference
xref: PTHR11849:SF161
xref: uniprot K7BJ65 698
organism: Pan troglodytes

STATE_TRANSITION_LEFT__GTP-_Ras-RIGHT__GDP-_Ras-_r20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 1228
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 1229
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 1226
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 1227
left: Ras
left: GTP
interaction type: STATE_TRANSITION
right: Ras
right: GDP

uniprot F6PX17 505
type: UnificationXref
id: F6PX17
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 404

uniprot Q63665 213
type: UnificationXref
id: Q63665
db: uniprot

uniprot A0A2R8Q947 901
type: UnificationXref
id: A0A2R8Q947
db: uniprot

uniprot Q99M51 285
type: UnificationXref
id: Q99M51
db: uniprot

Rho GTPase-activating protein 42
type: ProteinReference
xref: uniprot B2RQE8 967
organism: Mus musculus

uniprot A0A1D5QAB6 321
type: UnificationXref
id: A0A1D5QAB6
db: uniprot

uniprot F6WXL8 682
type: UnificationXref
id: F6WXL8
db: uniprot

-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
type: ProteinReference
xref: uniprot Q503B6 458
xref: PTHR24070:SF423
organism: Danio rerio

uniprot A0A452DI16 578
type: UnificationXref
id: A0A452DI16
db: uniprot

Rho GTPase-activating protein 15
type: ProteinReference
xref: uniprot A4IF90 962
xref: PTHR23176:SF108
organism: Bos taurus

RasGAP
type: Protein
entity reference: RasGAP
feature: RasGAP s45 a159 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P43288 361
type: UnificationXref
id: P43288
db: uniprot

PTHR10048:SF14
type: RelationshipXref
id: PTHR10048:SF14
db: PANTHER Family
relationship type: By Homology

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P17325 622
organism: Rattus norvegicus

uniprot A0A2I3TLP8 825
type: UnificationXref
id: A0A2I3TLP8
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot Q7QEQ3 942
organism: Anopheles gambiae

uniprot Q2NL51 368
type: UnificationXref
id: Q2NL51
db: uniprot

PKC
type: Protein
entity reference: PKC
feature: ACTIVE 18
feature: PKC s117 a113 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P42224 923
type: UnificationXref
id: P42224
db: uniprot

uniprot Q61120 1077
type: UnificationXref
id: Q61120
db: uniprot

Friend leukemia integration 1 transcription factor
type: ProteinReference
xref: uniprot Q29RS8 724
xref: PTHR11849:SF161
organism: Bos taurus

STAT s20 a52 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.459809653788574
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Nck
type: Protein
entity reference: Nck
feature: ACTIVE 18
feature: Nck s118 a161 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

cytoplasm
type: CellularLocationVocabulary
xref: GO GO:0005737 4

SAM pointed domain containing ets transcription factor
type: ProteinReference
xref: uniprot A2VDR4 659
xref: PTHR11849:SF182
organism: Bos taurus

uniprot A0A2J8QY32 752
type: UnificationXref
id: A0A2J8QY32
db: uniprot

uniprot Q9LV37 185
type: UnificationXref
id: Q9LV37
db: uniprot

PTHR23113:SF341
type: RelationshipXref
id: PTHR23113:SF341
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__Shc-_Grb2-_SOS-RIGHT__Complex__Grb2_Shc__SOS_-_r25
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 1211
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 1209
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 1210
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 1212
left: SOS
left: Grb2
left: Shc
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Grb2/Shc/ SOS)

MNK1 2 s81 a80 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ncbitaxon 5759 455
type: UnificationXref
id: 5759
db: ncbitaxon

uniprot F7BWW9 525
type: UnificationXref
id: F7BWW9
db: uniprot

uniprot F1PET4 830
type: UnificationXref
id: F1PET4
db: uniprot

uniprot P23726 797
type: UnificationXref
id: P23726
db: uniprot

uniprot P28482 153
type: UnificationXref
id: P28482
db: uniprot

uniprot P38339 1025
type: UnificationXref
id: P38339
db: uniprot

Protein kinase gsk31
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot Q9URT9 383
organism: Schizosaccharomyces pombe

uniprot F6Z499 413
type: UnificationXref
id: F6Z499
db: uniprot

Glycogen synthase kinase-3
type: ProteinReference
xref: uniprot Q9U2Q9 382
xref: PTHR24057:SF0
organism: Caenorhabditis elegans

uniprot P09619 497
type: UnificationXref
id: P09619
db: uniprot

ncbitaxon 10116 6
type: UnificationXref
id: 10116
db: ncbitaxon

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot A0A1D5R8E9 858
organism: Macaca mulatta

uniprot K7ALD7 425
type: UnificationXref
id: K7ALD7
db: uniprot

SOS
type: Protein
entity reference: SOS
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r31 1174
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r31 1173
type: Stoichiometry
physical entity: PDK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r31 1172
type: Stoichiometry
physical entity: PDK1/2
stoichiometric coefficient: 1.0

uniprot Q9VX32 1063
type: UnificationXref
id: Q9VX32
db: uniprot

uniprot H2QDK7 66
type: UnificationXref
id: H2QDK7
db: uniprot

uniprot F6UJK9 911
type: UnificationXref
id: F6UJK9
db: uniprot

uniprot Q0VC98 721
type: UnificationXref
id: Q0VC98
db: uniprot

Jak
type: Protein
entity reference: Jak
feature: Jak s112 a49 rs2
feature: ACTIVE 18
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot P23726 797
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r31 1171
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: uniprot P23727 798
xref: PTHR10155:SF3
organism: Bos taurus

uniprot Q1LVZ0 453
type: UnificationXref
id: Q1LVZ0
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot Q63932 615
organism: Mus musculus

uniprot Q9FVS6 378
type: UnificationXref
id: Q9FVS6
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F1NMJ9 475
xref: PTHR45807:SF5
organism: Gallus gallus

PDGF s129 a170 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PDGF
stoichiometric coefficient: 1.0

Ribosomal protein S6 kinase delta-1
type: ProteinReference
xref: uniprot Q96S38 90
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F6TAH0 864
organism: Monodelphis domestica

uniprot F7B6D9 686
type: UnificationXref
id: F7B6D9
db: uniprot

uniprot F7CYE3 135
type: UnificationXref
id: F7CYE3
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF3
xref: uniprot E1BEL4 472
organism: Bos taurus

Protein vav-1
type: ProteinReference
xref: uniprot Q45FX5 838
organism: Caenorhabditis elegans

uniprot P79737 448
type: UnificationXref
id: P79737
db: uniprot

uniprot E2RGT8 828
type: UnificationXref
id: E2RGT8
db: uniprot

uniprot F7GN93 140
type: UnificationXref
id: F7GN93
db: uniprot

STAT s122 a171 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ETS proto-oncogene 1, transcription factor
type: ProteinReference
xref: uniprot A0A3Q1LJJ3 654
xref: PTHR11849:SF209
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR11849:SF171
xref: uniprot A0A1D5QKT1 646
organism: Macaca mulatta

uniprot Q1LYG2 595
type: UnificationXref
id: Q1LYG2
db: uniprot

uniprot K7D3K8 920
type: UnificationXref
id: K7D3K8
db: uniprot

uniprot E2RH85 759
type: UnificationXref
id: E2RH85
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6X927 222
organism: Macaca mulatta

uniprot F7EI91 202
type: UnificationXref
id: F7EI91
db: uniprot

ETS-related transcription factor Elf-4
type: ProteinReference
xref: uniprot Q9Z2U4 743
xref: PTHR11849:SF170
organism: Mus musculus

uniprot Q12526 451
type: UnificationXref
id: Q12526
db: uniprot

uniprot Q62689 491
type: UnificationXref
id: Q62689
db: uniprot

uniprot Q61532 172
type: UnificationXref
id: Q61532
db: uniprot

uniprot K7AGG6 1017
type: UnificationXref
id: K7AGG6
db: uniprot

Rho GTPase-activating protein 12
type: ProteinReference
xref: uniprot Q8IWW6 1052
organism: Homo sapiens

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot G3V9W2 482
xref: PTHR45807:SF5
organism: Rattus norvegicus

ETS proto-oncogene 1, transcription factor
type: ProteinReference
xref: uniprot A0A2I3TF56 652
xref: PTHR11849:SF209
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot F6WX28 201
organism: Monodelphis domestica

ETS proto-oncogene 1, transcription factor
type: ProteinReference
xref: PTHR11849:SF209
xref: uniprot F7FH70 689
organism: Ornithorhynchus anatinus

Shc
type: Protein
entity reference: Shc
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa6 1098
feature: ACTIVE 18
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF14
xref: uniprot A0A3Q1LJI4 344
organism: Bos taurus

uniprot Q14573 563
type: UnificationXref
id: Q14573
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42336 802
organism: Homo sapiens

uniprot H2PZ66 483
type: UnificationXref
id: H2PZ66
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P42338 804
xref: PTHR10048:SF33
organism: Homo sapiens

PDK1/2
type: ProteinReference
xref: P01164
standard name: 3-phosphoinositide-dependent protein kinase 1 and 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.PDK1/2
comment: ENTITY_REFERENCE_NOTES= Long Name: 3'-Phosphoinositide-dependent protein kinase1/2 Synonym: PDK1,PDPK1 Accession: P01164
member entity reference: 3-phosphoinositide-dependent protein kinase 1
member entity reference: Serine/threonine-protein kinase PKH1
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase PKH3
member entity reference: Os01g0872800 protein
member entity reference: 3-phosphoinositide dependent protein kinase 1
member entity reference: Serine/threonine-protein kinase PKH2
member entity reference: Serine/threonine-protein kinase ksg1

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42337 803
organism: Mus musculus

Phosphatidylinositol 3-kinase VPS34
type: ProteinReference
xref: uniprot P42339 805
xref: PTHR10048:SF7
organism: Arabidopsis thaliana

PDGF
type: Protein
entity reference: PDGF
feature: COMPLEX PARTICIPANT BINDING FEATURE s128 a169 1084
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot O23145 355
type: UnificationXref
id: O23145
db: uniprot

Protein CBR-MEK-2
type: ProteinReference
xref: PTHR48013:SF19
xref: uniprot A8WWD7 599
organism: Caenorhabditis briggsae

uniprot P01111 430
type: UnificationXref
id: P01111
db: uniprot

SLIT-ROBO Rho GTPase-activating protein 1
type: ProteinReference
xref: uniprot F1M287 977
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__RasGAP-RIGHT__RasGAP-_r69
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 1145
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 1146
left: RasGAP
interaction type: STATE_TRANSITION
right: RasGAP

uniprot P11881 557
type: UnificationXref
id: P11881
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F1P859 520
xref: PTHR23113:SF150
organism: Canis lupus familiaris

uniprot H2R3U4 695
type: UnificationXref
id: H2R3U4
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot Q6PF93 815
xref: PTHR10048:SF7
organism: Mus musculus

E74-like ETS transcription factor 1
type: ProteinReference
xref: uniprot G3V9V2 691
xref: PTHR11849:SF156
organism: Rattus norvegicus

uniprot A0A3Q1NH21 313
type: UnificationXref
id: A0A3Q1NH21
db: uniprot

uniprot P42337 803
type: UnificationXref
id: P42337
db: uniprot

ncbitaxon 559292 308
type: UnificationXref
id: 559292
db: ncbitaxon

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot Q9Z329 568
organism: Mus musculus

uniprot F6PGQ1 350
type: UnificationXref
id: F6PGQ1
db: uniprot

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q95ME4 466
organism: Monodelphis domestica

uniprot F1Q2Q9 764
type: UnificationXref
id: F1Q2Q9
db: uniprot

Glycogen synthase kinase-3 alpha
type: ProteinReference
xref: uniprot P49840 363
xref: PTHR24057:SF14
organism: Homo sapiens

uniprot Q9NL43 380
type: UnificationXref
id: Q9NL43
db: uniprot

PDGF receptor B s4 sa2 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.8120576328758515
comment: MODIFICATION_RESIDUE_NAME=

uniprot Q8CIH5 873
type: UnificationXref
id: Q8CIH5
db: uniprot

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot P49841 364
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QP34 492
organism: Macaca mulatta

ETS domain-containing protein Elk-4
type: ProteinReference
xref: PTHR11849:SF21
xref: uniprot P41158 15
organism: Mus musculus

uniprot F7FR08 420
type: UnificationXref
id: F7FR08
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot F6VHF7 549
organism: Xenopus tropicalis

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot F6W7C8 773
organism: Macaca mulatta

uniprot A0A3Q2TVV5 345
type: UnificationXref
id: A0A3Q2TVV5
db: uniprot

uniprot P11346 589
type: UnificationXref
id: P11346
db: uniprot

uniprot A0A2R8QGN6 653
type: UnificationXref
id: A0A2R8QGN6
db: uniprot

Ca2+
type: SmallMolecule
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=ION

uniprot H2R8L2 1069
type: UnificationXref
id: H2R8L2
db: uniprot

Rho GTPase-activating protein 5
type: ProteinReference
xref: uniprot P97393 1028
organism: Mus musculus

GRB2-associated-binding protein 1
type: ProteinReference
xref: uniprot A0A0G2JZD5 235
organism: Rattus norvegicus

GRB2 associated binding protein 1
type: ProteinReference
xref: uniprot F6VDE6 244
organism: Monodelphis domestica

PTHR48019:SF40
type: RelationshipXref
id: PTHR48019:SF40
db: PANTHER Family
relationship type: By Homology

uniprot P18266 359
type: UnificationXref
id: P18266
db: uniprot

uniprot Q7PLZ7 840
type: UnificationXref
id: Q7PLZ7
db: uniprot

uniprot Q07292 594
type: UnificationXref
id: Q07292
db: uniprot

STAT s122 a171 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.459809653788574
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

ETS translocation variant 2
type: ProteinReference
xref: uniprot P41163 711
xref: PTHR11849:SF206
organism: Mus musculus

ETS translocation variant 3
type: ProteinReference
xref: uniprot P41162 710
xref: PTHR11849:SF30
organism: Homo sapiens

uniprot A8X0U6 965
type: UnificationXref
id: A8X0U6
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot Q61831 173
organism: Mus musculus

STAT s123 a173 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Ninein
type: ProteinReference
xref: uniprot Q8N4C6 373
organism: Homo sapiens

PDGF receptor B
type: Protein
entity reference: PDGF receptor B
feature: PDGF receptor B s2 a2 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Raf-1 proto-oncogene, serine/threonine kinase a
type: ProteinReference
xref: uniprot A0A0R4IC22 569
xref: PTHR44329:SF22
organism: Danio rerio

RAB11B, member RAS oncogene family, gene 1
type: ProteinReference
xref: uniprot F7CB58 416
organism: Xenopus tropicalis

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot F7D2D3 917
organism: Monodelphis domestica

Signal transducer and transcription activator
type: ProteinReference
xref: uniprot Q24151 938
organism: Drosophila melanogaster

PTHR10194:SF126
type: RelationshipXref
id: PTHR10194:SF126
db: PANTHER Family
relationship type: By Homology

uniprot F1MX21 546
type: UnificationXref
id: F1MX21
db: uniprot

Signal transducer and activator of transcription 4
type: ProteinReference
xref: PTHR11801:SF19
xref: uniprot Q14765 936
organism: Homo sapiens

uniprot Q95KV0 232
type: UnificationXref
id: Q95KV0
db: uniprot

uniprot Q8SSQ0 540
type: UnificationXref
id: Q8SSQ0
db: uniprot

uniprot Q66II3 263
type: UnificationXref
id: Q66II3
db: uniprot

STATE_TRANSITION_LEFT__Jak-_ATP-RIGHT__Jak-_ADP-_r18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 1106
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 1108
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 1107
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 1105
left: Jak
left: ATP
interaction type: STATE_TRANSITION
right: Jak
right: ADP

uniprot Q66IL5 264
type: UnificationXref
id: Q66IL5
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: ELK

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q9XT09 617
xref: PTHR48013:SF5
organism: Pan troglodytes

STAT
type: ProteinReference
xref: P01173
standard name: Signal transducers and activators of transcription
comment: ENTITY_REFERENCE_NOTES= Long Name: STAT Synonym: STAT1,STAT2,STAT3,STAT4,STAT5A,STAT5B,STAT6,Signal transducers and activators of transcription Accession: P01173
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.STAT
member entity reference: Signal transducer and activator of transcription
member entity reference: Signal transducer and activator of transcription 1
member entity reference: Signal transducer and activator of transcription 4
member entity reference: Signal transducer and activator of transcription 5B
member entity reference: Signal transducer and activator of transcription 5A
member entity reference: Signal transducer and transcription activator 6
member entity reference: Signal transducer and activator of transcription 6
member entity reference: Signal transducer and activator of transcription 1-alpha/beta
member entity reference: Signal transducer and activator of transcription 2
member entity reference: Signal transducer and activator of transcription 3
member entity reference: Signal transducer and transcription activator

uniprot Q812A2 1049
type: UnificationXref
id: Q812A2
db: uniprot

uniprot O43374 333
type: UnificationXref
id: O43374
db: uniprot

uniprot F7G4D2 204
type: UnificationXref
id: F7G4D2
db: uniprot

uniprot H2Q5J1 423
type: UnificationXref
id: H2Q5J1
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F1PIY7 476
xref: PTHR45807:SF5
organism: Canis lupus familiaris

uniprot H2QDQ1 303
type: UnificationXref
id: H2QDQ1
db: uniprot

Rho GTPase-activating protein 1
type: ProteinReference
xref: PTHR45808:SF6
xref: uniprot Q07960 1030
organism: Homo sapiens

uniprot F6Y841 774
type: UnificationXref
id: F6Y841
db: uniprot

PARTICIPANT STOICHIOMETRY r18 1108
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r18 1107
type: Stoichiometry
physical entity: Jak
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r18 1106
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r18 1105
type: Stoichiometry
physical entity: Jak
stoichiometric coefficient: 1.0

uniprot F7CHH2 915
type: UnificationXref
id: F7CHH2
db: uniprot

uniprot Q54QB1 164
type: UnificationXref
id: Q54QB1
db: uniprot

Ikk s64 a97 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q9V3I5 94
type: UnificationXref
id: Q9V3I5
db: uniprot

uniprot A0A2I3TRY9 750
type: UnificationXref
id: A0A2I3TRY9
db: uniprot

uniprot G2HGD2 248
type: UnificationXref
id: G2HGD2
db: uniprot

AGAP010292-PA (Fragment)
type: ProteinReference
xref: uniprot Q7PLZ7 840
organism: Anopheles gambiae

MNK1/2
type: ProteinReference
xref: P01149
standard name: Mitogen-activated protein kinase-interacting serine/threonine kinase1/2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.MNK1/2
comment: ENTITY_REFERENCE_NOTES= Long Name: MNK1/2 Synonym: MAPK-interacting kinase 1/2,MKNK1,MNK2 Accession: P01149
member entity reference: MAP kinase-interacting serine/threonine-protein kinase 1
member entity reference: MAP kinase-interacting serine/threonine-protein kinase 2
member entity reference: MAP kinase-interacting serine/threonine-protein kinase 2 isoform 2
member entity reference: Uncharacterized protein
member entity reference: MAP kinase interacting serine/threonine kinase 2

uniprot P32253 445
type: UnificationXref
id: P32253
db: uniprot

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot A0A3Q1LSJ2 106
organism: Bos taurus

ETS translocation variant 3
type: ProteinReference
xref: PTHR11849:SF30
xref: uniprot A2T762 658
organism: Pan troglodytes

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A1D5QL06 22
xref: PTHR24351:SF98
organism: Macaca mulatta

uniprot A0A2I3T4Q0 217
type: UnificationXref
id: A0A2I3T4Q0
db: uniprot

uniprot P42228 927
type: UnificationXref
id: P42228
db: uniprot

uniprot G7MGQ5 785
type: UnificationXref
id: G7MGQ5
db: uniprot

uniprot A0A2I3SIY1 748
type: UnificationXref
id: A0A2I3SIY1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot F7HHY8 506
organism: Macaca mulatta

SHC-transforming protein 3
type: ProteinReference
xref: PTHR10337:SF4
xref: uniprot O70143 1071
organism: Rattus norvegicus

SHC-transforming protein 2
type: ProteinReference
xref: PTHR10337:SF5
xref: uniprot O70142 1070
organism: Rattus norvegicus

Transcriptional regulator
type: ProteinReference
xref: uniprot Q6P1T1 888
xref: PTHR45851:SF1
organism: Xenopus tropicalis

uniprot P27986 800
type: UnificationXref
id: P27986
db: uniprot

uniprot A0A2I3S8A4 24
type: UnificationXref
id: A0A2I3S8A4
db: uniprot

Serum response factor homolog
type: ProteinReference
xref: uniprot Q24535 641
organism: Drosophila melanogaster

Rho GTPase activating protein 15
type: ProteinReference
xref: uniprot E2RAB4 975
xref: PTHR23176:SF108
organism: Canis lupus familiaris

uniprot O60674 485
type: UnificationXref
id: O60674
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF3
xref: uniprot A0A2J8LTH4 470
organism: Pan troglodytes

uniprot F6W5V4 996
type: UnificationXref
id: F6W5V4
db: uniprot

uniprot H9EPM1 354
type: UnificationXref
id: H9EPM1
db: uniprot

uniprot E1BE66 757
type: UnificationXref
id: E1BE66
db: uniprot

uniprot Q4Z8P1 727
type: UnificationXref
id: Q4Z8P1
db: uniprot

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot J9P5W6 603
organism: Canis lupus familiaris

MAP2K1 protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q0VD16 610
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR13168:SF0
xref: uniprot F6XRU8 879
organism: Ornithorhynchus anatinus

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F6QUW1 522
organism: Monodelphis domestica

STAT s123 a173 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.459809653788574
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 3

Protein FEV
type: ProteinReference
xref: PTHR11849:SF203
xref: uniprot O70132 699
organism: Rattus norvegicus

Myc proto-oncogene protein
type: ProteinReference
xref: PTHR45851:SF1
xref: uniprot Q2HJ27 887
organism: Bos taurus

STATE_TRANSITION_LEFT__ATP-_ERK-RIGHT__ERK-_ADP-_r23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1218
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1217
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1219
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1216
left: ERK
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: ERK

PARTICIPANT STOICHIOMETRY r71 1142
type: Stoichiometry
physical entity: Nck
stoichiometric coefficient: 1.0

PTHR45807:SF2
type: RelationshipXref
id: PTHR45807:SF2
db: PANTHER Family
relationship type: By Homology

MEK
type: Protein
entity reference: MEK
feature: MEK s23 a69 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r71 1141
type: Stoichiometry
physical entity: Nck
stoichiometric coefficient: 1.0

uniprot Q8QZW2 732
type: UnificationXref
id: Q8QZW2
db: uniprot

PTHR45807:SF1
type: RelationshipXref
id: PTHR45807:SF1
db: PANTHER Family
relationship type: By Homology

PTHR45807:SF3
type: RelationshipXref
id: PTHR45807:SF3
db: PANTHER Family
relationship type: By Homology

PTHR45807:SF5
type: RelationshipXref
id: PTHR45807:SF5
db: PANTHER Family
relationship type: By Homology

PTHR24351:SF110
type: RelationshipXref
id: PTHR24351:SF110
db: PANTHER Family
relationship type: By Homology

uniprot F1PAE3 349
type: UnificationXref
id: F1PAE3
db: uniprot

uniprot O35904 793
type: UnificationXref
id: O35904
db: uniprot

PTHR24351:SF115
type: RelationshipXref
id: PTHR24351:SF115
db: PANTHER Family
relationship type: By Homology

ncbitaxon 45351 397
type: UnificationXref
id: 45351
db: ncbitaxon

uniprot P36506 606
type: UnificationXref
id: P36506
db: uniprot

PKB
type: Protein
entity reference: PKB
feature: ACTIVE 18
feature: PKB s104 a156 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

GRB2-related adapter protein
type: ProteinReference
xref: PTHR46037:SF2
xref: uniprot Q9CX99 268
organism: Mus musculus

MAP2K2 isoform 1
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot K7BYT0 604
organism: Pan troglodytes

PIK3R1 isoform 1
type: ProteinReference
xref: uniprot A0A2I3SIY1 748
xref: PTHR10155:SF3
organism: Pan troglodytes

uniprot O77628 207
type: UnificationXref
id: O77628
db: uniprot

uniprot F1MSX4 121
type: UnificationXref
id: F1MSX4
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot O93599 921
xref: PTHR11801:SF2
organism: Danio rerio

IP3 receptor
type: ProteinReference
xref: P01160
standard name: inositol 1,4,5-triphosphate receptor
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.ION_CHANNEL.IP3_br_receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES= Long Name: IP3 receptor Synonym: INOSITOL 1,4,5-TRIPHOSPHATE RECEPTOR Accession: P01160
member entity reference: AGAP006475-PA
member entity reference: Inositol 1,4,5-trisphosphate receptor type 3
member entity reference: Inositol 1,4,5-trisphosphate receptor
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1
member entity reference: Protein CBR-ITR-1, isoform a
member entity reference: Inositol 1,4,5-trisphosphate receptor itr-1
member entity reference: Uncharacterized protein
member entity reference: Inositol 1,4,5-trisphosphate receptor type 2
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1 isoform 3

Serum response factor
type: ProteinReference
xref: uniprot F7BXX1 639
xref: PTHR48019:SF40
organism: Xenopus tropicalis

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7FDA0 781
xref: PTHR10048:SF33
organism: Monodelphis domestica

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot P31938 605
organism: Mus musculus

Vav s119 a162 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR11139:SF9
type: RelationshipXref
id: PTHR11139:SF9
db: PANTHER Family
relationship type: By Homology

uniprot Q5F3L1 84
type: UnificationXref
id: Q5F3L1
db: uniprot

Signal transducer and activator of transcription 3
type: ProteinReference
xref: uniprot P40763 922
xref: PTHR11801:SF2
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot F6VQP7 550
organism: Monodelphis domestica

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot P70227 561
organism: Mus musculus

Tyrosine-protein kinase JAK1
type: ProteinReference
xref: uniprot P23458 486
xref: PTHR45807:SF5
organism: Homo sapiens

Protein kinase C-like 1
type: ProteinReference
xref: uniprot P24583 307
xref: PTHR24356:SF390
organism: Saccharomyces cerevisiae

DAG
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ETS homologous factor
type: ProteinReference
xref: PTHR11849:SF171
xref: uniprot A2T737 657
organism: Pan troglodytes

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF110
xref: uniprot Q7QDB4 86
organism: Anopheles gambiae

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E1B8P9 115
xref: PTHR24055:SF393
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot Q18955 640
organism: Caenorhabditis elegans

Ets
type: Protein
entity reference: Ets
feature: Ets s87 a137 rs1
feature: ACTIVE 18
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P41163 711
type: UnificationXref
id: P41163
db: uniprot

uniprot F0ZVH9 406
type: UnificationXref
id: F0ZVH9
db: uniprot

uniprot Q9C9U4 182
type: UnificationXref
id: Q9C9U4
db: uniprot

MAP kinase-interacting serine/threonine-protein kinase 2
type: ProteinReference
xref: PTHR24349:SF254
xref: uniprot Q8CDB0 295
organism: Mus musculus

uniprot P43289 362
type: UnificationXref
id: P43289
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot K7CZM1 528
xref: PTHR23113:SF150
organism: Pan troglodytes

PTHR24351:SF171
type: RelationshipXref
id: PTHR24351:SF171
db: PANTHER Family
relationship type: By Homology

uniprot Q32LN0 725
type: UnificationXref
id: Q32LN0
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 52

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: uniprot P23443 75
xref: PTHR24351:SF48
organism: Homo sapiens

uniprot Q95ME4 466
type: UnificationXref
id: Q95ME4
db: uniprot

uniprot A0A2J8LTH4 470
type: UnificationXref
id: A0A2J8LTH4
db: uniprot

uniprot F1N0D6 474
type: UnificationXref
id: F1N0D6
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q5SN53 169
xref: PTHR24055:SF187
organism: Oryza sativa

uniprot F6TFL4 127
type: UnificationXref
id: F6TFL4
db: uniprot

uniprot F6SHC1 220
type: UnificationXref
id: F6SHC1
db: uniprot

uniprot A6NI28 963
type: UnificationXref
id: A6NI28
db: uniprot

STAT
type: Protein
entity reference: STAT
feature: STAT s127 a172 rs1
feature: ACTIVE 18
feature: STAT s127 a172 rs2

uniprot F6UWI0 55
type: UnificationXref
id: F6UWI0
db: uniprot

Ets s77 a135 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A0A2I3SED2 322
type: UnificationXref
id: A0A2I3SED2
db: uniprot

PARTICIPANT STOICHIOMETRY r22 1223
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Platelet-derived growth factor receptor beta
type: ProteinReference
xref: uniprot F7BTH1 494
organism: Macaca mulatta

uniprot P04627 585
type: UnificationXref
id: P04627
db: uniprot

PARTICIPANT STOICHIOMETRY r22 1222
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 1221
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r49 1114
type: Stoichiometry
physical entity: Ets
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 1220
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r49 1113
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r49 1116
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r49 1115
type: Stoichiometry
physical entity: Ets
stoichiometric coefficient: 1.0

PTHR24055:SF414
type: RelationshipXref
id: PTHR24055:SF414
db: PANTHER Family
relationship type: By Homology

uniprot Q8N4C6 373
type: UnificationXref
id: Q8N4C6
db: uniprot

uniprot O00329 790
type: UnificationXref
id: O00329
db: uniprot

Cytoplasmic protein NCK1
type: ProteinReference
xref: PTHR19969:SF16
xref: uniprot Q99M51 285
organism: Mus musculus

uniprot I2CU78 834
type: UnificationXref
id: I2CU78
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E823 136
xref: PTHR24055:SF203
organism: Monodelphis domestica

uniprot Q14571 562
type: UnificationXref
id: Q14571
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot F7A818 552
organism: Macaca mulatta

uniprot A0A2I3TQ88 899
type: UnificationXref
id: A0A2I3TQ88
db: uniprot

ETS-related transcription factor Elf-2
type: ProteinReference
xref: uniprot Q9JHC9 739
xref: PTHR11849:SF10
organism: Mus musculus

uniprot P01119 432
type: UnificationXref
id: P01119
db: uniprot

SRF
type: Protein
entity reference: SRF
feature: SRF s99 a126 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Proto-oncogene vav
type: ProteinReference
xref: uniprot P15498 835
xref: PTHR45818:SF2
organism: Homo sapiens

uniprot Q7ZVK8 176
type: UnificationXref
id: Q7ZVK8
db: uniprot

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot A0A2I3TK00 576
xref: PTHR44329:SF47
organism: Pan troglodytes

PTHR24055:SF429
type: RelationshipXref
id: PTHR24055:SF429
db: PANTHER Family
relationship type: By Homology

ETS-related transcription factor Elf-3
type: ProteinReference
xref: PTHR11849:SF13
xref: uniprot P78545 715
organism: Homo sapiens

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 41

uniprot R4GIA5 468
type: UnificationXref
id: R4GIA5
db: uniprot

uniprot F7BVQ1 865
type: UnificationXref
id: F7BVQ1
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F1PNW8 907
xref: PTHR11801:SF39
organism: Canis lupus familiaris

uniprot F7C0E0 301
type: UnificationXref
id: F7C0E0
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F1MAI3 518
xref: PTHR23113:SF150
organism: Rattus norvegicus

uniprot O17789 427
type: UnificationXref
id: O17789
db: uniprot

uniprot P46941 1026
type: UnificationXref
id: P46941
db: uniprot

PARTICIPANT STOICHIOMETRY r32 1170
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q99581 736
type: UnificationXref
id: Q99581
db: uniprot

uniprot Q80Y86 177
type: UnificationXref
id: Q80Y86
db: uniprot

STATE_TRANSITION_LEFT__ATP-_p90RSK-RIGHT__p90RSK-_ADP-_r27
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 1199
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 1200
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 1198
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 1197
left: ATP
left: p90RSK
interaction type: STATE_TRANSITION
right: ADP
right: p90RSK

Serum response factor
type: ProteinReference
xref: uniprot F7FP88 203
xref: PTHR48019:SF40
organism: Monodelphis domestica

PTHR24055:SF420
type: RelationshipXref
id: PTHR24055:SF420
db: PANTHER Family
relationship type: By Homology

c-Jun
type: ProteinReference
xref: P01163
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.c-Jun
comment: ENTITY_REFERENCE_NOTES= Long Name: c-Jun Synonym: Synonym not specified Accession: P01163
member entity reference: Jun proto-oncogene, AP-1 transcription factor subunit
member entity reference: Transcription factor AP-1
member entity reference: Jun proto-oncogene
member entity reference: COP9 signalosome complex subunit 5b

uniprot P27577 706
type: UnificationXref
id: P27577
db: uniprot

Platelet-derived growth factor subunit A
type: ProteinReference
xref: uniprot P28576 853
organism: Rattus norvegicus

ncbitaxon 5664 512
type: UnificationXref
id: 5664
db: ncbitaxon

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF47
xref: uniprot F7CHH2 915
organism: Monodelphis domestica

uniprot P05627 621
type: UnificationXref
id: P05627
db: uniprot

uniprot F1M287 977
type: UnificationXref
id: F1M287
db: uniprot

Ras-related protein Rab-11B
type: ProteinReference
xref: uniprot Q3MHP2 457
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r32 1167
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot P03967 434
type: UnificationXref
id: P03967
db: uniprot

Ras-related and estrogen-regulated growth inhibitor
type: ProteinReference
xref: uniprot Q0VCJ7 450
organism: Bos taurus

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot A3R0S3 239
xref: PTHR46037:SF4
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r32 1169
type: Stoichiometry
physical entity: PKB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r32 1168
type: Stoichiometry
physical entity: PKB
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7EH19 137
organism: Xenopus tropicalis

uniprot F1PH12 200
type: UnificationXref
id: F1PH12
db: uniprot

uniprot Q91Y86 180
type: UnificationXref
id: Q91Y86
db: uniprot

BAD s54 a151 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Vav s108 a160 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SRF s101 a123 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PDGFB protein
type: ProteinReference
xref: uniprot B1H0W5 845
organism: Bos taurus

uniprot E2RPB0 762
type: UnificationXref
id: E2RPB0
db: uniprot

c-Jun
type: Protein
entity reference: c-Jun
feature: c Jun s90 a140 rs1
feature: ACTIVE 18
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Ribosomal protein S6 kinase alpha-3
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot P51812 76
organism: Homo sapiens

mTOR
type: Protein
entity reference: mTOR
feature: ACTIVE 18
feature: mTOR s58 a155 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Protein FEV
type: ProteinReference
xref: uniprot Q8QZW2 732
xref: PTHR11849:SF203
organism: Mus musculus

uniprot Q24535 641
type: UnificationXref
id: Q24535
db: uniprot

uniprot F6Q2Q1 985
type: UnificationXref
id: F6Q2Q1
db: uniprot

c-Myc
type: ProteinReference
xref: P01172
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.c-Myc
comment: ENTITY_REFERENCE_NOTES= Long Name: c-Myc Synonym: Synonym not specified Accession: P01172
member entity reference: Transcriptional regulator Myc-B
member entity reference: c-Myc-binding protein
member entity reference: Myc proto-oncogene protein
member entity reference: Transcriptional regulator Myc-A
member entity reference: Uncharacterized protein
member entity reference: Protein B-Myc
member entity reference: Myc-binding protein
member entity reference: At2g14045
member entity reference: Transcriptional regulator
member entity reference: Myc protein

uniprot P15498 835
type: UnificationXref
id: P15498
db: uniprot

uniprot F1N599 675
type: UnificationXref
id: F1N599
db: uniprot

Rho GTPase-activating protein 15
type: ProteinReference
xref: PTHR23176:SF108
xref: uniprot Q811M1 1048
organism: Mus musculus

Ras GTPase-activating protein 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot P20936 334
organism: Homo sapiens

GRB2-related adapter protein 2
type: ProteinReference
xref: PTHR46037:SF3
xref: uniprot F7AN37 245
organism: Macaca mulatta

Friend leukemia integration 1 transcription factor
type: ProteinReference
xref: PTHR11849:SF161
xref: uniprot P26323 705
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: uniprot Q5ANK2 311
xref: PTHR24356:SF390
organism: Candida albicans

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F6SDH6 50
xref: PTHR24351:SF41
organism: Macaca mulatta

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot Q9JHG7 821
xref: PTHR10048:SF34
organism: Mus musculus

uniprot E2RCV1 758
type: UnificationXref
id: E2RCV1
db: uniprot

uniprot P51812 76
type: UnificationXref
id: P51812
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot H2PZ66 483
xref: PTHR45807:SF5
organism: Pan troglodytes

PKB
type: ProteinReference
xref: P01151
standard name: Protein kinase B
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.PKB
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: PROTEIN KINASE B-BETA Synonym: AKT2,PKB,V-AKT MURINE THYMOMA VIRAL ONCOGENE HOMOLOG 2 Accession: P01151
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC-beta serine/threonine-protein kinase

Tyrosine-protein kinase JAK2
type: ProteinReference
xref: PTHR45807:SF1
xref: uniprot O60674 485
organism: Homo sapiens

Rho GTPase activating protein at 16F, isoform E
type: ProteinReference
xref: PTHR23176:SF113
xref: uniprot X2JCF3 1064
organism: Drosophila melanogaster

uniprot P29776 707
type: UnificationXref
id: P29776
db: uniprot

uniprot Q9XT09 617
type: UnificationXref
id: Q9XT09
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__c_fos-RIGHT__c_fos-_r50
controller: p90RSK

uniprot F7FLZ2 352
type: UnificationXref
id: F7FLZ2
db: uniprot

SLIT-ROBO Rho GTPase-activating protein 1
type: ProteinReference
xref: uniprot G7N7I9 1007
organism: Macaca mulatta

VAV1 isoform 2
type: ProteinReference
xref: uniprot H2QF58 833
xref: PTHR45818:SF2
organism: Pan troglodytes

uniprot P08646 437
type: UnificationXref
id: P08646
db: uniprot

uniprot P11345 588
type: UnificationXref
id: P11345
db: uniprot

uniprot H2QKD0 866
type: UnificationXref
id: H2QKD0
db: uniprot

uniprot H2RA86 146
type: UnificationXref
id: H2RA86
db: uniprot

uniprot A0A1D5R9U8 570
type: UnificationXref
id: A0A1D5R9U8
db: uniprot

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot O88351 227
organism: Mus musculus

Putative glycogen synthase kinase-3 homolog
type: ProteinReference
xref: uniprot P83101 366
xref: PTHR24057:SF0
organism: Drosophila melanogaster

ETS-related transcription factor Elf-4
type: ProteinReference
xref: uniprot Q99607 737
xref: PTHR11849:SF170
organism: Homo sapiens

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P47197 318
organism: Rattus norvegicus

uniprot F6S443 412
type: UnificationXref
id: F6S443
db: uniprot

uniprot A0A1D5NWT4 19
type: UnificationXref
id: A0A1D5NWT4
db: uniprot

Serum response factor homolog A
type: ProteinReference
xref: uniprot Q54TY7 642
organism: Dictyostelium discoideum

SLIT-ROBO Rho GTPase-activating protein 1b
type: ProteinReference
xref: uniprot B7ZVG9 968
xref: PTHR14166:SF15
organism: Danio rerio

uniprot Q15907 452
type: UnificationXref
id: Q15907
db: uniprot

Rho GTPase-activating protein 15
type: ProteinReference
xref: uniprot F7H6M3 1004
xref: PTHR23176:SF108
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PIP2-RIGHT__PIP3-_r30
controller: PI3K

SOS s17 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

Slit-Robo GAP homolog
type: ProteinReference
xref: uniprot Q19370 1033
organism: Caenorhabditis elegans

uniprot F6Y1Z2 683
type: UnificationXref
id: F6Y1Z2
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot A0A1D5R985 298
xref: PTHR24356:SF193
organism: Macaca mulatta

uniprot E1BMX0 400
type: UnificationXref
id: E1BMX0
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot D3ZSB7 35
xref: PTHR24351:SF41
organism: Rattus norvegicus

uniprot A0A2R8Q8S1 393
type: UnificationXref
id: A0A2R8Q8S1
db: uniprot

uniprot Q60823 319
type: UnificationXref
id: Q60823
db: uniprot

Friend leukemia integration 1 transcription factor
type: ProteinReference
xref: uniprot Q01543 718
xref: PTHR11849:SF161
organism: Homo sapiens

STATE_TRANSITION_LEFT__ATP-_Ets-RIGHT__Ets-_ADP-_r49
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 1116
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 1113
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 1115
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 1114
left: Ets
left: ATP
interaction type: STATE_TRANSITION
right: Ets
right: ADP

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF16
xref: uniprot Q1LZB2 284
organism: Bos taurus

ncbitaxon 6239 83
type: UnificationXref
id: 6239
db: ncbitaxon

PTHR24070:SF189
type: RelationshipXref
id: PTHR24070:SF189
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_MNK1_2-RIGHT__MNK1_2-_ADP-_r26
controller: ERK

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VDT1 993
xref: PTHR12552:SF4
organism: Macaca mulatta

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A2I3S8A4 24
xref: PTHR24351:SF98
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r40 1140
type: Stoichiometry
physical entity: Complex (PDGF receptor A/PDGF receptor B)
stoichiometric coefficient: 1.0

uniprot F1MET2 673
type: UnificationXref
id: F1MET2
db: uniprot

Mitogen-activated protein kinase 7
type: ProteinReference
xref: PTHR24055:SF356
xref: uniprot Q13164 159
organism: Homo sapiens

STATE_TRANSITION_LEFT__Vav-RIGHT__Vav-_r73
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 1135
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 1136
left: Vav
interaction type: STATE_TRANSITION
right: Vav

uniprot F7ATZ3 685
type: UnificationXref
id: F7ATZ3
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 87

LOC100170599 protein
type: ProteinReference
xref: uniprot B3DM35 662
xref: PTHR11849:SF209
organism: Xenopus tropicalis

uniprot Q5U2N4 293
type: UnificationXref
id: Q5U2N4
db: uniprot

uniprot P08647 438
type: UnificationXref
id: P08647
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7F3S0 780
organism: Macaca mulatta

GTPase KRas
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F6Z5N3 414
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r73 1135
type: Stoichiometry
physical entity: Vav
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r73 1136
type: Stoichiometry
physical entity: Vav
stoichiometric coefficient: 1.0

uniprot D4ACQ9 668
type: UnificationXref
id: D4ACQ9
db: uniprot

GRB2 associated binding protein 1
type: ProteinReference
xref: uniprot F1P7F6 243
organism: Canis lupus familiaris

PTHR45818:SF2
type: RelationshipXref
id: PTHR45818:SF2
db: PANTHER Family
relationship type: By Homology

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot A0A1D5QKD3 597
organism: Macaca mulatta

PTHR45818:SF1
type: RelationshipXref
id: PTHR45818:SF1
db: PANTHER Family
relationship type: By Homology

PTHR24055:SF356
type: RelationshipXref
id: PTHR24055:SF356
db: PANTHER Family
relationship type: By Homology

uniprot P05625 586
type: UnificationXref
id: P05625
db: uniprot

RAS p21 protein activator 2
type: ProteinReference
xref: uniprot H2QNH9 331
xref: PTHR10194:SF21
organism: Pan troglodytes

uniprot A0A2I3T4N0 956
type: UnificationXref
id: A0A2I3T4N0
db: uniprot

uniprot D3ZYG0 826
type: UnificationXref
id: D3ZYG0
db: uniprot

PTHR45818:SF4
type: RelationshipXref
id: PTHR45818:SF4
db: PANTHER Family
relationship type: By Homology

BAD
type: Protein
feature: BAD s61 a148 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot Q93372 375
organism: Caenorhabditis elegans

Ras-related and estrogen-regulated growth inhibitor
type: ProteinReference
xref: uniprot Q8R367 465
organism: Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot P48736 806
xref: PTHR10048:SF34
organism: Homo sapiens

E74-like ETS transcription factor 4
type: ProteinReference
xref: PTHR11849:SF170
xref: uniprot D3ZWM8 666
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r40 1138
type: Stoichiometry
physical entity: PDGF receptor B
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF48
xref: uniprot Q1KQ07 937
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r40 1139
type: Stoichiometry
physical entity: PDGF receptor A
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot H2PXY8 786
organism: Pan troglodytes

uniprot Q60631 262
type: UnificationXref
id: Q60631
db: uniprot

PARTICIPANT STOICHIOMETRY r40 1137
type: Stoichiometry
physical entity: PDGF
stoichiometric coefficient: 1.0

uniprot E1BLQ5 38
type: UnificationXref
id: E1BLQ5
db: uniprot

uniprot P01101 209
type: UnificationXref
id: P01101
db: uniprot

uniprot Q6TLK4 1043
type: UnificationXref
id: Q6TLK4
db: uniprot

ELK
type: ProteinReference
xref: P01140
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: ELK Synonym: MEMBER OF ETS ONCOGENE FAMILY Accession: P01140
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.ELK
member entity reference: ETS domain-containing protein Elk-4 isoform a
member entity reference: ETS domain-containing protein Elk-4
member entity reference: ELK4, ETS transcription factor
member entity reference: ETS domain-containing protein Elk-1

uniprot D4A5Q1 756
type: UnificationXref
id: D4A5Q1
db: uniprot

MEK s26 a70 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r28 1193
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Oligophrenin-1
type: ProteinReference
xref: uniprot Q7YQL6 1046
organism: Pan troglodytes

uniprot F7H6M3 1004
type: UnificationXref
id: F7H6M3
db: uniprot

PARTICIPANT STOICHIOMETRY r28 1196
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

ncbitaxon 13616 58
type: UnificationXref
id: 13616
db: ncbitaxon

Ribosomal protein S6 kinase alpha-4
type: ProteinReference
xref: uniprot Q9Z2B9 99
xref: PTHR24351:SF41
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r28 1194
type: Stoichiometry
physical entity: MAPKAPK2
stoichiometric coefficient: 1.0

uniprot P52633 935
type: UnificationXref
id: P52633
db: uniprot

uniprot Q9Z1S8 272
type: UnificationXref
id: Q9Z1S8
db: uniprot

PARTICIPANT STOICHIOMETRY r28 1195
type: Stoichiometry
physical entity: MAPKAPK2
stoichiometric coefficient: 1.0

uniprot P23443 75
type: UnificationXref
id: P23443
db: uniprot

PARTICIPANT STOICHIOMETRY r29 1192
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r29 1191
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Nck-RIGHT__Nck-_r71
controller: Complex (PDGF receptor A/PDGF receptor B)

StAR-related lipid transfer protein 13
type: ProteinReference
xref: uniprot Q923Q2 1056
organism: Mus musculus

uniprot F1MJI3 981
type: UnificationXref
id: F1MJI3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot F6V2H6 128
organism: Monodelphis domestica

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05412 620
organism: Homo sapiens

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: uniprot P27986 800
xref: PTHR10155:SF3
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r30 1180
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

uniprot Q9HBH9 297
type: UnificationXref
id: Q9HBH9
db: uniprot

uniprot P62993 254
type: UnificationXref
id: P62993
db: uniprot

uniprot A0A3Q1LSJ2 106
type: UnificationXref
id: A0A3Q1LSJ2
db: uniprot

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot Q3T0F9 259
xref: PTHR46037:SF4
organism: Bos taurus

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot H9FYU7 527
xref: PTHR23113:SF150
organism: Macaca mulatta

STATE_TRANSITION_LEFT__IP3_receptor-RIGHT__IP3_receptor-_r82
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 1232
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 1233
left: IP3 receptor
interaction type: STATE_TRANSITION
right: IP3 receptor

GTP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r30 1179
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

uniprot Q8BWW9 312
type: UnificationXref
id: Q8BWW9
db: uniprot

uniprot Q8R2S1 89
type: UnificationXref
id: Q8R2S1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FLZ2 352
organism: Macaca mulatta

uniprot F1PJZ0 983
type: UnificationXref
id: F1PJZ0
db: uniprot

Ras guanine nucleotide exchange factor P
type: ProteinReference
xref: uniprot Q54TK8 534
organism: Dictyostelium discoideum

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot A2VDR4 659
type: UnificationXref
id: A2VDR4
db: uniprot

uniprot A0A3Q1MLN6 30
type: UnificationXref
id: A0A3Q1MLN6
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1PMN2 122
organism: Canis lupus familiaris

PTHR24055:SF378
type: RelationshipXref
id: PTHR24055:SF378
db: PANTHER Family
relationship type: By Homology

ELK4, ETS transcription factor
type: ProteinReference
xref: uniprot B4F7D4 9
xref: PTHR11849:SF21
organism: Rattus norvegicus

PTHR10337:SF4
type: RelationshipXref
id: PTHR10337:SF4
db: PANTHER Family
relationship type: By Homology

PTHR10337:SF2
type: RelationshipXref
id: PTHR10337:SF2
db: PANTHER Family
relationship type: By Homology

uniprot F6UMM2 912
type: UnificationXref
id: F6UMM2
db: uniprot

Guanine nucleotide exchange factor VAV2
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot P52735 837
organism: Homo sapiens

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A1D5Q3X8 21
xref: PTHR24351:SF115
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NCY7 503
organism: Gallus gallus

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot F1M9D0 120
organism: Rattus norvegicus

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q9Z2A0 638
organism: Mus musculus

Mitogen-activated protein kinase 15
type: ProteinReference
xref: PTHR24055:SF79
xref: uniprot Q9Z2A6 190
organism: Rattus norvegicus

PTHR24351:SF98
type: RelationshipXref
id: PTHR24351:SF98
db: PANTHER Family
relationship type: By Homology

PTHR10337:SF5
type: RelationshipXref
id: PTHR10337:SF5
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase JAK1
type: ProteinReference
xref: uniprot P52332 487
xref: PTHR45807:SF5
organism: Mus musculus

STATE_TRANSITION_LEFT__ATP-_MAPKAPK2-RIGHT__MAPKAPK2-_ADP-_r28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 1196
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 1193
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 1194
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 1195
left: MAPKAPK2
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: MAPKAPK2

Mitogen-activated protein kinase 7
type: ProteinReference
xref: PTHR24055:SF356
xref: uniprot A5PKJ4 110
organism: Bos taurus

Tyrosine-protein kinase JAK3
type: ProteinReference
xref: uniprot P52333 488
xref: PTHR45807:SF3
organism: Homo sapiens

P01147
type: UnificationXref
id: P01147
db: PANTHER Pathway Component

uniprot A0A1D5RFQ9 236
type: UnificationXref
id: A0A1D5RFQ9
db: uniprot

P01146
type: UnificationXref
id: P01146
db: PANTHER Pathway Component

P01145
type: UnificationXref
id: P01145
db: PANTHER Pathway Component

P01144
type: UnificationXref
id: P01144
db: PANTHER Pathway Component

P01143
type: UnificationXref
id: P01143
db: PANTHER Pathway Component

P01142
type: UnificationXref
id: P01142
db: PANTHER Pathway Component

Ribosomal protein S6 kinase-like 1
type: ProteinReference
xref: uniprot Q8R2S1 89
organism: Mus musculus

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F6TPX7 51
xref: PTHR24351:SF48
organism: Ornithorhynchus anatinus

P01140
type: UnificationXref
id: P01140
db: PANTHER Pathway Component

ncbitaxon 9606 13
type: UnificationXref
id: 9606
db: ncbitaxon

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7FHD1 139
xref: PTHR24055:SF203
organism: Monodelphis domestica

uniprot P52333 488
type: UnificationXref
id: P52333
db: uniprot

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot O55173 627
organism: Rattus norvegicus

uniprot F6RTT3 989
type: UnificationXref
id: F6RTT3
db: uniprot

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: uniprot Q6TJY3 85
xref: PTHR24351:SF48
organism: Bos taurus

uniprot F1A411 408
type: UnificationXref
id: F1A411
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot D4AE24 37
xref: PTHR24351:SF171
organism: Rattus norvegicus

uniprot Q8BMC3 1079
type: UnificationXref
id: Q8BMC3
db: uniprot

PDGF receptor B s4 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PDGF receptor B
stoichiometric coefficient: 1.0

uniprot E2RPW6 473
type: UnificationXref
id: E2RPW6
db: uniprot

uniprot P42226 925
type: UnificationXref
id: P42226
db: uniprot

uniprot A0A0G2K5T3 745
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

P01156
type: UnificationXref
id: P01156
db: PANTHER Pathway Component

DISSOCIATION
type: InteractionVocabulary

P01155
type: UnificationXref
id: P01155
db: PANTHER Pathway Component

P01158
type: UnificationXref
id: P01158
db: PANTHER Pathway Component

RAS p21 protein activator (GTPase activating protein) 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot H2QR74 332
organism: Pan troglodytes

P01157
type: UnificationXref
id: P01157
db: PANTHER Pathway Component

uniprot Q9Z268 340
type: UnificationXref
id: Q9Z268
db: uniprot

P01152
type: UnificationXref
id: P01152
db: PANTHER Pathway Component

Platelet-derived growth factor subunit B
type: ProteinReference
xref: uniprot Q6Q7I7 855
organism: Canis lupus familiaris

FEV, ETS transcription factor
type: ProteinReference
xref: PTHR11849:SF203
xref: uniprot F1N1U5 674
organism: Bos taurus

P01151
type: UnificationXref
id: P01151
db: PANTHER Pathway Component

P01154
type: UnificationXref
id: P01154
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TYX0 680
xref: PTHR11849:SF13
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F5HEA9 123
xref: PTHR24055:SF158
organism: Phaeosphaeria nodorum

P01153
type: UnificationXref
id: P01153
db: PANTHER Pathway Component

PTHR45808:SF6
type: RelationshipXref
id: PTHR45808:SF6
db: PANTHER Family
relationship type: By Homology

uniprot Q06546 720
type: UnificationXref
id: Q06546
db: uniprot

P01150
type: UnificationXref
id: P01150
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__GTP-_Rho-RIGHT__GDP-_Rho-_r77
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 1134
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 1131
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 1132
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 1133
left: Rho
left: GTP
interaction type: STATE_TRANSITION
right: Rho
right: GDP

uniprot Q39011 369
type: UnificationXref
id: Q39011
db: uniprot

PKC
type: Protein
entity reference: PKC
feature: PKC s117 a108 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot A0A2I3SXI2 341
organism: Pan troglodytes

uniprot F1P1X4 547
type: UnificationXref
id: F1P1X4
db: uniprot

ncbitaxon 6238 33
type: UnificationXref
id: 6238
db: ncbitaxon

PI-3 kinase
type: ProteinReference
xref: uniprot P91634 811
xref: PTHR10048:SF14
organism: Drosophila melanogaster

uniprot E2RKR0 218
type: UnificationXref
id: E2RKR0
db: uniprot

uniprot F1MIZ6 980
type: UnificationXref
id: F1MIZ6
db: uniprot

PDGF
type: Protein
entity reference: PDGF
comment: SPECIES_TYPE=PROTEIN

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 574
xref: uniprot Q99N57 596
xref: PTHR44329:SF22
organism: Mus musculus

P01148
type: UnificationXref
id: P01148
db: PANTHER Pathway Component

uniprot P32252 444
type: UnificationXref
id: P32252
db: uniprot

P01149
type: UnificationXref
id: P01149
db: PANTHER Pathway Component

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 13

uniprot F1PRG4 314
type: UnificationXref
id: F1PRG4
db: uniprot

mTOR
type: ProteinReference
xref: P01144
standard name: mammalian target of rapamycin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: mTOR Synonym: FK506-BINDING PROTEIN 12-RAPAMYCIN COMPLEX-ASSOCIATED PROTEIN 1,FRAP,mTOR Accession: P01144
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.mTOR
member entity reference: Serine/threonine-protein kinase Tor

uniprot Q6AYD8 1042
type: UnificationXref
id: Q6AYD8
db: uniprot

c Myc s76 a136 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot O00459 791
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot A7F871 395
organism: Sclerotinia sclerotiorum

uniprot A7STP5 396
type: UnificationXref
id: A7STP5
db: uniprot

uniprot P63086 158
type: UnificationXref
id: P63086
db: uniprot

PTHR24351:SF41
type: RelationshipXref
id: PTHR24351:SF41
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6Y4G8 130
xref: PTHR24055:SF222
organism: Canis lupus familiaris

PTHR24351:SF43
type: RelationshipXref
id: PTHR24351:SF43
db: PANTHER Family
relationship type: By Homology

Nck s118 a161 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F6WX28 201
type: UnificationXref
id: F6WX28
db: uniprot

PTHR24351:SF48
type: RelationshipXref
id: PTHR24351:SF48
db: PANTHER Family
relationship type: By Homology

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: uniprot Q60680 229
organism: Mus musculus

uniprot P18653 73
type: UnificationXref
id: P18653
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot Q1HG70 612
organism: Canis lupus familiaris

uniprot Q8LNI5 372
type: UnificationXref
id: Q8LNI5
db: uniprot

uniprot O54834 1023
type: UnificationXref
id: O54834
db: uniprot

uniprot Q61043 371
type: UnificationXref
id: Q61043
db: uniprot

Elongator complex protein 1
type: ProteinReference
xref: uniprot Q7TT37 230
organism: Mus musculus

ETS-related transcription factor Elf-1
type: ProteinReference
xref: uniprot P32519 708
xref: PTHR11849:SF156
organism: Homo sapiens

GTPase HRas
type: ProteinReference
xref: uniprot P08642 436
xref: PTHR24070:SF423
organism: Gallus gallus

uniprot F6S876 48
type: UnificationXref
id: F6S876
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot A0A1D5NWT4 19
organism: Gallus gallus

uniprot Q9U2Q9 382
type: UnificationXref
id: Q9U2Q9
db: uniprot

STATE_TRANSITION_LEFT__ATP-_STAT-RIGHT__STAT-_ADP-_r17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 1112
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 1110
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 1111
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 1109
left: STAT
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: STAT

uniprot A0A3Q2TY19 108
type: UnificationXref
id: A0A3Q2TY19
db: uniprot

uniprot F7EPN2 330
type: UnificationXref
id: F7EPN2
db: uniprot

uniprot E2R6T4 618
type: UnificationXref
id: E2R6T4
db: uniprot

PTHR24351:SF58
type: RelationshipXref
id: PTHR24351:SF58
db: PANTHER Family
relationship type: By Homology

uniprot Q63269 566
type: UnificationXref
id: Q63269
db: uniprot

uniprot Q8WYR1 819
type: UnificationXref
id: Q8WYR1
db: uniprot

ETS-related transcription factor Elf-2
type: ProteinReference
xref: PTHR11849:SF10
xref: uniprot Q15723 722
organism: Homo sapiens

uniprot P38615 360
type: UnificationXref
id: P38615
db: uniprot

Ras-like protein 1
type: ProteinReference
xref: uniprot P08647 438
organism: Schizosaccharomyces pombe

Ras-like protein 1
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot P08646 437
organism: Drosophila melanogaster

uniprot Q9Z2A6 190
type: UnificationXref
id: Q9Z2A6
db: uniprot

uniprot A0A0G2K1Z2 950
type: UnificationXref
id: A0A0G2K1Z2
db: uniprot

uniprot A8XFY3 32
type: UnificationXref
id: A8XFY3
db: uniprot

SHC-transforming protein 2
type: ProteinReference
xref: uniprot Q8BMC3 1079
xref: PTHR10337:SF5
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r60 1189
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

uniprot Q53QZ3 1035
type: UnificationXref
id: Q53QZ3
db: uniprot

GAB2 isoform 1
type: ProteinReference
xref: uniprot H2R3E1 250
organism: Pan troglodytes

uniprot K7DH81 69
type: UnificationXref
id: K7DH81
db: uniprot

uniprot P05412 620
type: UnificationXref
id: P05412
db: uniprot

uniprot H2QFS6 787
type: UnificationXref
id: H2QFS6
db: uniprot

uniprot J9P5W6 603
type: UnificationXref
id: J9P5W6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF14
xref: uniprot F1PAE3 349
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LS58 655
xref: PTHR11849:SF216
organism: Bos taurus

uniprot A0A2I3SG90 955
type: UnificationXref
id: A0A2I3SG90
db: uniprot

uniprot F6WBW6 129
type: UnificationXref
id: F6WBW6
db: uniprot

uniprot F7F5K9 418
type: UnificationXref
id: F7F5K9
db: uniprot

PDGF receptor A
type: ProteinReference
xref: P01158
standard name: Platelet-Derived Growth Factor A
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.RECEPTOR.PDGF_br_receptor A
comment: ENTITY_REFERENCE_NOTES= Long Name: PDGF receptor A Synonym: PDGF receptor/CSF1 receptor family,PDGFR2 Accession: P01158
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Platelet-derived growth factor receptor alpha
member entity reference: Platelet-derived growth factor receptor-like protein

PTHR11849:SF171
type: RelationshipXref
id: PTHR11849:SF171
db: PANTHER Family
relationship type: By Homology

Protein CBG07560
type: ProteinReference
xref: uniprot A8X4K1 346
organism: Caenorhabditis briggsae

PTHR11849:SF170
type: RelationshipXref
id: PTHR11849:SF170
db: PANTHER Family
relationship type: By Homology

uniprot A0A3Q1LJI4 344
type: UnificationXref
id: A0A3Q1LJI4
db: uniprot

PDK1/2
type: Protein
entity reference: PDK1/2
feature: PDK1 2 s32 a95 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Nck-RIGHT__Nck-_r71
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 1141
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 1142
left: Nck
interaction type: STATE_TRANSITION
right: Nck

uniprot Q9VXH3 874
type: UnificationXref
id: Q9VXH3
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q9VR61 96
xref: PTHR24351:SF110
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r78 1126
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

uniprot F7DUD6 778
type: UnificationXref
id: F7DUD6
db: uniprot

PARTICIPANT STOICHIOMETRY r78 1125
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

uniprot K7BI90 68
type: UnificationXref
id: K7BI90
db: uniprot

PTHR11849:SF178
type: RelationshipXref
id: PTHR11849:SF178
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r61 1187
type: Stoichiometry
physical entity: GSK3
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QXL5 647
xref: PTHR11849:SF209
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r61 1186
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r61 1185
type: Stoichiometry
physical entity: GSK3
stoichiometric coefficient: 1.0

PDGF receptor A
type: Protein
entity reference: PDGF receptor A
feature: PDGF receptor A s1 a1 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5QPR1 895
type: UnificationXref
id: A0A1D5QPR1
db: uniprot

ncbitaxon 367110 192
type: UnificationXref
id: 367110
db: ncbitaxon

Raf
type: ProteinReference
xref: P01161
standard name: Raf Oncogene
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.Raf
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1 Synonym: ONCOGENE RAF1 Accession: P01161
member entity reference: B-Raf proto-oncogene, serine/threonine kinase
member entity reference: Raf homolog serine/threonine-protein kinase
member entity reference: A-Raf proto-oncogene, serine/threonine kinase
member entity reference: Raf-1 proto-oncogene, serine/threonine kinase a
member entity reference: RAF proto-oncogene serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase A-Raf
member entity reference: Uncharacterized protein
member entity reference: Raf homolog serine/threonine-protein kinase Raf
member entity reference: Raf-1 proto-oncogene, serine/threonine kinase
member entity reference: Serine/threonine-protein kinase B-raf

uniprot E9I1I7 401
type: UnificationXref
id: E9I1I7
db: uniprot

Fli-1 proto-oncogene, ETS transcription factor a
type: ProteinReference
xref: PTHR11849:SF161
xref: uniprot A0A2R8QGN6 653
organism: Danio rerio

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Glycogen synthase kinase-3 alpha
type: ProteinReference
xref: PTHR24057:SF14
xref: uniprot Q2NL51 368
organism: Mus musculus

c-Myc
type: Protein
entity reference: c-Myc
feature: c Myc s76 a136 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Os01g0296100 protein
type: ProteinReference
xref: PTHR24057:SF34
xref: uniprot Q94IZ2 376
organism: Oryza sativa

AGAP011768-PA
type: ProteinReference
xref: PTHR46037:SF1
xref: uniprot Q7PV64 267
organism: Anopheles gambiae

HRas proto-oncogene, GTPase a
type: ProteinReference
xref: uniprot F1QNG4 411
xref: PTHR24070:SF423
organism: Danio rerio

PTHR11849:SF182
type: RelationshipXref
id: PTHR11849:SF182
db: PANTHER Family
relationship type: By Homology

E74 like ETS transcription factor 3
type: ProteinReference
xref: uniprot A0A2I3SJJ2 649
xref: PTHR11849:SF13
organism: Pan troglodytes

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: uniprot A0A2I3T4Q0 217
organism: Pan troglodytes

Serine/threonine-protein kinase Tor
type: ProteinReference
xref: uniprot Q9VK45 193
xref: PTHR11139:SF9
organism: Drosophila melanogaster

uniprot P41158 15
type: UnificationXref
id: P41158
db: uniprot

RAB11B, member RAS oncogene family
type: ProteinReference
xref: uniprot J9JHN1 424
organism: Canis lupus familiaris

STAT
type: Protein
entity reference: STAT
feature: STAT s122 a171 rs2
feature: STAT s122 a171 rs1
feature: ACTIVE 18

uniprot E2RMD8 42
type: UnificationXref
id: E2RMD8
db: uniprot

uniprot P27704 152
type: UnificationXref
id: P27704
db: uniprot

PARTICIPANT STOICHIOMETRY r61 1188
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot A0A2I3SPS3 650
type: UnificationXref
id: A0A2I3SPS3
db: uniprot

Mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot A0A3S5ZPX3 598
organism: Bos taurus

STATE_TRANSITION_LEFT__mTOR-_ATP-RIGHT__mTOR-_ADP-_r63
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 1175
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 1178
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 1177
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 1176
left: mTOR
left: ATP
interaction type: STATE_TRANSITION
right: mTOR
right: ADP

uniprot P42338 804
type: UnificationXref
id: P42338
db: uniprot

Rho GTPase-activating protein 6
type: ProteinReference
xref: uniprot O43182 1021
organism: Homo sapiens

Phosphatidylinositol 3-kinase VPS34-like
type: ProteinReference
xref: uniprot P54676 810
xref: PTHR10048:SF7
organism: Dictyostelium discoideum

Phosphatidylinositol 3-kinase 3
type: ProteinReference
xref: PTHR10048:SF48
xref: uniprot P54675 809
organism: Dictyostelium discoideum

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MYM3 763
xref: PTHR10048:SF33
organism: Bos taurus

Phosphatidylinositol 3-kinase 2
type: ProteinReference
xref: uniprot P54674 808
xref: PTHR10048:SF109
organism: Dictyostelium discoideum

Phosphatidylinositol 3-kinase 1
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot P54673 807
organism: Dictyostelium discoideum

uniprot P50548 712
type: UnificationXref
id: P50548
db: uniprot

PDGF receptor B s6 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PDGF receptor B
stoichiometric coefficient: 1.0

uniprot P32519 708
type: UnificationXref
id: P32519
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P10686 868
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot H2KZV6 1008
organism: Caenorhabditis elegans

ETS2 repressor factor
type: ProteinReference
xref: PTHR11849:SF31
xref: uniprot J9NXI6 697
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Ikk-RIGHT__Ikk-_ADP-_r33
controller: PKB

uniprot F7FH70 689
type: UnificationXref
id: F7FH70
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot F6YLX1 479
organism: Macaca mulatta

uniprot Q9XF67 636
type: UnificationXref
id: Q9XF67
db: uniprot

uniprot Q96S38 90
type: UnificationXref
id: Q96S38
db: uniprot

PTHR11849:SF156
type: RelationshipXref
id: PTHR11849:SF156
db: PANTHER Family
relationship type: By Homology

uniprot F6RWK1 990
type: UnificationXref
id: F6RWK1
db: uniprot

Pk34A
type: ProteinReference
xref: uniprot Q9VK37 384
organism: Drosophila melanogaster

uniprot H9ENT4 67
type: UnificationXref
id: H9ENT4
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A3Q1LNQ6 27
xref: PTHR24351:SF213
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r38 1143
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

GRB2-associated-binding protein 1
type: ProteinReference
xref: uniprot Q9QYY0 270
organism: Mus musculus

p90RSK
type: Protein
entity reference: p90RSK
feature: p90RSK s80 a84 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Vav guanine nucleotide exchange factor 3
type: ProteinReference
xref: uniprot F1PET4 830
xref: PTHR45818:SF1
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r38 1144
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PDGF receptor B
type: Protein
entity reference: PDGF receptor B
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa2 1088
feature: PDGF receptor B s4 sa2 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F6T0E0 991
type: UnificationXref
id: F6T0E0
db: uniprot

uniprot H2QIS7 1011
type: UnificationXref
id: H2QIS7
db: uniprot

uniprot Q8VHU4 231
type: UnificationXref
id: Q8VHU4
db: uniprot

uniprot I0FUV2 205
type: UnificationXref
id: I0FUV2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Jak-_ATP-RIGHT__Jak-_ADP-_r18
controller: Jak

Mitogen-activated protein kinase 7
type: ProteinReference
xref: PTHR24055:SF356
xref: uniprot P0C865 149
organism: Rattus norvegicus

Shc
type: Protein
entity reference: Shc
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r60 1190
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

MNK1/2
type: Protein
entity reference: MNK1/2
feature: ACTIVE 18
feature: MNK1 2 s83 a77 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YLW2 131
organism: Macaca mulatta

PTHR11849:SF161
type: RelationshipXref
id: PTHR11849:SF161
db: PANTHER Family
relationship type: By Homology

uniprot H9EP11 289
type: UnificationXref
id: H9EP11
db: uniprot

Phosphoinositide 3-kinase regulatory subunit 5
type: ProteinReference
xref: PTHR15593:SF2
xref: uniprot Q8WYR1 819
organism: Homo sapiens

uniprot H2QQ79 249
type: UnificationXref
id: H2QQ79
db: uniprot

uniprot P23727 798
type: UnificationXref
id: P23727
db: uniprot

PKC
type: ProteinReference
xref: P01150
standard name: Protein kinase C
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.PKC
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Protein kinase C Synonym: Synonym not specified Accession: P01150
member entity reference: Serine/threonine-protein kinase N2
member entity reference: Protein kinase C alpha type
member entity reference: Protein kinase C
member entity reference: Protein kinase C-like 2
member entity reference: PKN2 isoform 2
member entity reference: Protein kinase C-like 1
member entity reference: Uncharacterized protein

Shaggy-related protein kinase beta
type: ProteinReference
xref: PTHR24057:SF51
xref: uniprot O23145 355
organism: Arabidopsis thaliana

PDGF receptor A
type: Protein
entity reference: PDGF receptor A
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa3 1092
feature: ACTIVE 18
feature: PDGF receptor A s5 sa3 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P01108 882
type: UnificationXref
id: P01108
db: uniprot

PARTICIPANT STOICHIOMETRY r69 1145
type: Stoichiometry
physical entity: RasGAP
stoichiometric coefficient: 1.0

uniprot F6VAQ8 770
type: UnificationXref
id: F6VAQ8
db: uniprot

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot Q9WVS8 187
xref: PTHR24055:SF356
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r69 1146
type: Stoichiometry
physical entity: RasGAP
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot P28028 592
organism: Mus musculus

uniprot Q9NHV9 841
type: UnificationXref
id: Q9NHV9
db: uniprot

SHC-transforming protein 2
type: ProteinReference
xref: uniprot P98077 1073
xref: PTHR10337:SF5
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR24356:SF322
xref: uniprot F7C0E0 301
organism: Macaca mulatta

uniprot E1BCP6 471
type: UnificationXref
id: E1BCP6
db: uniprot

uniprot P98083 1074
type: UnificationXref
id: P98083
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot A0A3Q1LXK8 29
xref: PTHR24351:SF98
organism: Bos taurus

Harvey rat sarcoma viral oncogene homolog
type: ProteinReference
xref: uniprot Q28EW2 456
xref: PTHR24070:SF423
organism: Xenopus tropicalis

uniprot Q811M1 1048
type: UnificationXref
id: Q811M1
db: uniprot

uniprot A0A3Q1N7P8 542
type: UnificationXref
id: A0A3Q1N7P8
db: uniprot

Protein C-ets-1
type: ProteinReference
xref: uniprot P41156 709
xref: PTHR11849:SF209
organism: Rattus norvegicus

uniprot A0A1D5QXL5 647
type: UnificationXref
id: A0A1D5QXL5
db: uniprot

uniprot Q9Z2A0 638
type: UnificationXref
id: Q9Z2A0
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A0R4IKK9 101
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot E9I1I7 401
xref: PTHR24070:SF420
organism: Daphnia pulex

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: uniprot Q8CIH5 873
xref: PTHR10336:SF25
organism: Mus musculus

uniprot Q28EW2 456
type: UnificationXref
id: Q28EW2
db: uniprot

PDGF receptor A s3 sa1 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.547240302970063

STATE_TRANSITION_LEFT__GSK3-_ATP-RIGHT__GSK3-_ADP-_r61
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 1185
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 1187
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 1186
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 1188
left: GSK3
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: GSK3

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QZX3 23
organism: Macaca mulatta

Ras GTPase-activating protein 2
type: ProteinReference
xref: uniprot Q15283 337
xref: PTHR10194:SF21
organism: Homo sapiens

Candida albicans
type: BioSource
xref: ncbitaxon 237561 167

ncbitaxon 5786 404
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot A0A2I3SXI2 341
type: UnificationXref
id: A0A2I3SXI2
db: uniprot

PARTICIPANT STOICHIOMETRY r63 1175
type: Stoichiometry
physical entity: mTOR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r63 1176
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

C-fos
type: ProteinReference
xref: uniprot A5A6H0 195
xref: PTHR23351:SF4
organism: Pan troglodytes

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r63 1177
type: Stoichiometry
physical entity: mTOR
stoichiometric coefficient: 1.0

uniprot F1PHV7 410
type: UnificationXref
id: F1PHV7
db: uniprot

PARTICIPANT STOICHIOMETRY r63 1178
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

SHC-transforming protein 1
type: ProteinReference
xref: uniprot P98083 1074
xref: PTHR10337:SF2
organism: Mus musculus

PIP3
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

C-fos
type: ProteinReference
xref: uniprot A5A6H2 196
xref: PTHR23351:SF4
organism: Macaca mulatta

uniprot P32871 801
type: UnificationXref
id: P32871
db: uniprot

Ets
type: Protein
entity reference: Ets
feature: Ets s77 a135 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

ETS-related transcription factor Elf-5
type: ProteinReference
xref: PTHR11849:SF15
xref: uniprot Q9UKW6 741
organism: Homo sapiens

Leishmania major
type: BioSource
xref: ncbitaxon 5664 512

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: uniprot H2QNG6 788
xref: PTHR10048:SF33
organism: Pan troglodytes

ncbitaxon 7719 381
type: UnificationXref
id: 7719
db: ncbitaxon

Guanine nucleotide exchange factor VAV3
type: ProteinReference
xref: PTHR45818:SF1
xref: uniprot Q9UKW4 843
organism: Homo sapiens

V-ets avian erythroblastosis virus E26 oncogene homolog
type: ProteinReference
xref: PTHR11849:SF216
xref: uniprot B4F6M4 663
organism: Xenopus tropicalis

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A7F3M0 111
xref: PTHR24055:SF158
organism: Sclerotinia sclerotiorum

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: SRF

uniprot D3ZEY9 664
type: UnificationXref
id: D3ZEY9
db: uniprot

uniprot F6YJ34 57
type: UnificationXref
id: F6YJ34
db: uniprot

uniprot Q6P943 941
type: UnificationXref
id: Q6P943
db: uniprot

uniprot P41969 17
type: UnificationXref
id: P41969
db: uniprot

Elongator complex protein 1
type: ProteinReference
xref: uniprot F6TAF3 221
organism: Macaca mulatta

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot A0A0G2K3R1 100
organism: Rattus norvegicus

PTHR11849:SF191
type: RelationshipXref
id: PTHR11849:SF191
db: PANTHER Family
relationship type: By Homology

uniprot F1MAI3 518
type: UnificationXref
id: F1MAI3
db: uniprot

uniprot A0A3Q1LWV5 958
type: UnificationXref
id: A0A3Q1LWV5
db: uniprot

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q9Y1J3 637
organism: Caenorhabditis elegans

PDK1/2
type: Protein
entity reference: PDK1/2
feature: PDK1 2 s33 a96 rs1
feature: ACTIVE 18
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR11849:SF195
type: RelationshipXref
id: PTHR11849:SF195
db: PANTHER Family
relationship type: By Homology

uniprot F7CQS0 61
type: UnificationXref
id: F7CQS0
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7GN93 140
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EBP6 417
organism: Monodelphis domestica

Rho GTPase activating protein 9
type: ProteinReference
xref: uniprot A0A2I3T4N0 956
xref: PTHR23176:SF103
organism: Pan troglodytes

ETS-related transcription factor Elf-3
type: ProteinReference
xref: uniprot Q3UPW2 726
xref: PTHR11849:SF13
organism: Mus musculus

Axon STeering defect
type: ProteinReference
xref: uniprot Q22355 723
xref: PTHR11849:SF287
organism: Caenorhabditis elegans

Rho GTPase-activating protein 6
type: ProteinReference
xref: uniprot O54834 1023
organism: Mus musculus

PTHR11633:SF3
type: RelationshipXref
id: PTHR11633:SF3
db: PANTHER Family
relationship type: By Homology

ERK s24 a71 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A0A3Q3ACS4 754
type: UnificationXref
id: A0A3Q3ACS4
db: uniprot

uniprot P08556 435
type: UnificationXref
id: P08556
db: uniprot

uniprot Q5SN53 169
type: UnificationXref
id: Q5SN53
db: uniprot

uniprot F5HEA9 123
type: UnificationXref
id: F5HEA9
db: uniprot

uniprot P42232 930
type: UnificationXref
id: P42232
db: uniprot

Platelet-derived growth factor subunit A
type: ProteinReference
xref: uniprot F6WRD7 847
organism: Xenopus tropicalis

PTHR24055:SF79
type: RelationshipXref
id: PTHR24055:SF79
db: PANTHER Family
relationship type: By Homology

uniprot Q812A5 1050
type: UnificationXref
id: Q812A5
db: uniprot

uniprot Q61083 171
type: UnificationXref
id: Q61083
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F1MGJ4 904
xref: PTHR11801:SF48
organism: Bos taurus

uniprot P05622 496
type: UnificationXref
id: P05622
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF19
xref: uniprot F7CW94 916
organism: Monodelphis domestica

PDGF receptor A s3 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PDGF receptor A
stoichiometric coefficient: 1.0

uniprot P01127 850
type: UnificationXref
id: P01127
db: uniprot

FEV, ETS transcription factor
type: ProteinReference
xref: uniprot F6WXL8 682
xref: PTHR11849:SF203
organism: Monodelphis domestica

uniprot O70132 699
type: UnificationXref
id: O70132
db: uniprot

Os01g0252100 protein
type: ProteinReference
xref: PTHR24057:SF48
xref: uniprot Q9LIS6 379
organism: Oryza sativa

p90RSK s94 a121 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 571
xref: uniprot P04049 584
xref: PTHR44329:SF22
organism: Homo sapiens

PKB s34 a101 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot Q1KQ07 937
type: UnificationXref
id: Q1KQ07
db: uniprot

Upstream stimulatory factor 2
type: ProteinReference
xref: uniprot Q64705 214
organism: Mus musculus

uniprot O46404 794
type: UnificationXref
id: O46404
db: uniprot

uniprot Q22355 723
type: UnificationXref
id: Q22355
db: uniprot

PTHR24356:SF176
type: RelationshipXref
id: PTHR24356:SF176
db: PANTHER Family
relationship type: By Homology

RPS6KC1 isoform 1
type: ProteinReference
xref: uniprot H2Q147 64
organism: Pan troglodytes

Phosphoinositide-3-kinase regulatory subunit 1
type: ProteinReference
xref: uniprot F1Q2Q9 764
xref: PTHR10155:SF3
organism: Canis lupus familiaris

Ras family GTPase
type: ProteinReference
xref: uniprot Q24806 454
organism: Entamoeba histolytica

uniprot A0A1D5QP34 492
type: UnificationXref
id: A0A1D5QP34
db: uniprot

uniprot A0A2I3T4A4 824
type: UnificationXref
id: A0A2I3T4A4
db: uniprot

ETS homologous factor
type: ProteinReference
xref: uniprot Q32LN0 725
xref: PTHR11849:SF171
organism: Bos taurus

uniprot A8WWD7 599
type: UnificationXref
id: A8WWD7
db: uniprot

uniprot P0C865 149
type: UnificationXref
id: P0C865
db: uniprot

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot Q9Y2U5 188
organism: Homo sapiens

Ras GTPase-activating protein 4B
type: ProteinReference
xref: uniprot C9J798 324
xref: PTHR10194:SF4
organism: Homo sapiens

uniprot F1PNW8 907
type: UnificationXref
id: F1PNW8
db: uniprot

ETS homologous factor
type: ProteinReference
xref: PTHR11849:SF171
xref: uniprot Q9NZC4 740
organism: Homo sapiens

uniprot Q15349 80
type: UnificationXref
id: Q15349
db: uniprot

V-fos FBJ murine osteosarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot Q6P0S4 215
organism: Danio rerio

uniprot D4AB50 974
type: UnificationXref
id: D4AB50
db: uniprot

uniprot A0A2I3THL4 575
type: UnificationXref
id: A0A2I3THL4
db: uniprot

uniprot P98171 1029
type: UnificationXref
id: P98171
db: uniprot

Signal transducer and activator of transcription 2
type: ProteinReference
xref: PTHR11801:SF41
xref: uniprot Q9WVL2 945
organism: Mus musculus

uniprot Q9TYT3 1081
type: UnificationXref
id: Q9TYT3
db: uniprot

uniprot A0A0G2K7N9 951
type: UnificationXref
id: A0A0G2K7N9
db: uniprot

Cytoplasmic protein NCK2
type: ProteinReference
xref: PTHR19969:SF12
xref: uniprot O43639 281
organism: Homo sapiens

Rho GTPase-activating protein 42
type: ProteinReference
xref: uniprot A6NI28 963
organism: Homo sapiens

uniprot P46638 447
type: UnificationXref
id: P46638
db: uniprot

uniprot P49071 508
type: UnificationXref
id: P49071
db: uniprot

uniprot Q5RKN6 261
type: UnificationXref
id: Q5RKN6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9UA62 634
organism: Caenorhabditis elegans

STAT s127 a172 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

uniprot F1P7F6 243
type: UnificationXref
id: F1P7F6
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot Q14643 564
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Shc-_Grb2-_SOS-RIGHT__Complex__Grb2_Shc__SOS_-_r25
controller: Complex (PDGF receptor A/PDGF receptor B)

Shc
type: ProteinReference
xref: P01175
standard name: SH2 homology domain containing transforming protein
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.Shc
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Shc Synonym: Synonym not specified Accession: P01175
member entity reference: DShc protein
member entity reference: Uncharacterized protein
member entity reference: AGAP011463-PA
member entity reference: SHC-transforming protein 2
member entity reference: SHC-transforming protein 1
member entity reference: SHC-transforming protein 3
member entity reference: SHC-transforming protein homolog 1
member entity reference: SHC adaptor protein 3
member entity reference: SHC (Src homology 2 domain containing) transforming protein 1

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot O77628 207
organism: Bos taurus

uniprot Q5FWK3 1037
type: UnificationXref
id: Q5FWK3
db: uniprot

PTHR24356:SF193
type: RelationshipXref
id: PTHR24356:SF193
db: PANTHER Family
relationship type: By Homology

ncbitaxon 7165 87
type: UnificationXref
id: 7165
db: ncbitaxon

ETS domain-containing transcription factor ERF
type: ProteinReference
xref: PTHR11849:SF31
xref: uniprot H9Z692 696
organism: Macaca mulatta

uniprot P47197 318
type: UnificationXref
id: P47197
db: uniprot

SHC-transforming protein 3
type: ProteinReference
xref: PTHR10337:SF4
xref: uniprot Q61120 1077
organism: Mus musculus

Myc-binding protein
type: ProteinReference
xref: PTHR13168:SF0
xref: uniprot D4A7F2 877
organism: Rattus norvegicus

uniprot Q9Y1J3 637
type: UnificationXref
id: Q9Y1J3
db: uniprot

STATE_TRANSITION_LEFT__PKB-RIGHT__PKB-_Pi-_r34
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1157
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1156
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1158
left: PKB
interaction type: STATE_TRANSITION
right: Pi
right: PKB

STARD13 isoform 4
type: ProteinReference
xref: uniprot K7CMU6 1019
organism: Pan troglodytes

uniprot F0ZWE6 407
type: UnificationXref
id: F0ZWE6
db: uniprot

uniprot Q23130 1034
type: UnificationXref
id: Q23130
db: uniprot

uniprot F7BZL6 777
type: UnificationXref
id: F7BZL6
db: uniprot

uniprot P01120 433
type: UnificationXref
id: P01120
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot F6V2V1 56
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r77 1131
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Glycogen synthase kinase 3 alpha
type: ProteinReference
xref: uniprot H2QGF9 353
xref: PTHR24057:SF14
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5F3R8 461
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r77 1133
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r77 1132
type: Stoichiometry
physical entity: Rho
stoichiometric coefficient: 1.0

uniprot P49138 510
type: UnificationXref
id: P49138
db: uniprot

PARTICIPANT STOICHIOMETRY r77 1134
type: Stoichiometry
physical entity: Rho
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PKB-RIGHT__PKB-_ADP-_r32
controller: PDK1/2

uniprot H2R3E1 250
type: UnificationXref
id: H2R3E1
db: uniprot

Transcriptional regulator ERG
type: ProteinReference
xref: uniprot P11308 702
xref: PTHR11849:SF216
organism: Homo sapiens

ETS domain-containing protein Elk-1
type: ProteinReference
xref: uniprot A4GTP4 5
xref: PTHR11849:SF178
organism: Rattus norvegicus

uniprot P18265 358
type: UnificationXref
id: P18265
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF47
xref: uniprot A0A1D5QPR1 895
organism: Macaca mulatta

uniprot Q6PF93 815
type: UnificationXref
id: Q6PF93
db: uniprot

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF16
xref: uniprot G2HHN0 279
organism: Pan troglodytes

uniprot Q96287 377
type: UnificationXref
id: Q96287
db: uniprot

Cytoplasmic protein
type: ProteinReference
xref: uniprot F7ALW1 276
xref: PTHR19969:SF12
organism: Monodelphis domestica

uniprot F7EBP6 417
type: UnificationXref
id: F7EBP6
db: uniprot

STATE_TRANSITION_LEFT__ATP-_MEK-RIGHT__MEK-_ADP-_r22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 1221
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 1222
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 1220
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 1223
left: MEK
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: MEK

Dual specificity mitogen-activated protein kinase kinase mek-2
type: ProteinReference
xref: PTHR48013:SF19
xref: uniprot Q10664 611
organism: Caenorhabditis elegans

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot K7D3K8 920
xref: PTHR11801:SF48
organism: Pan troglodytes

uniprot Q7QK91 464
type: UnificationXref
id: Q7QK91
db: uniprot

uniprot J9NXI6 697
type: UnificationXref
id: J9NXI6
db: uniprot

PTHR44329:SF193
type: RelationshipXref
id: PTHR44329:SF193
db: PANTHER Family
relationship type: By Homology

Platelet-derived growth factor receptor beta
type: ProteinReference
xref: uniprot P09619 497
organism: Homo sapiens

Platelet-derived growth factor subunit A
type: ProteinReference
xref: uniprot P04085 851
xref: PTHR11633:SF3
organism: Homo sapiens

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot Q95KV0 232
organism: Bos taurus

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: uniprot Q95KV1 233
organism: Bos taurus

uniprot F1NMJ9 475
type: UnificationXref
id: F1NMJ9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EJL2 832
xref: PTHR45818:SF1
organism: Monodelphis domestica

uniprot F7GJG7 246
type: UnificationXref
id: F7GJG7
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 25

uniprot H2Q104 507
type: UnificationXref
id: H2Q104
db: uniprot

uniprot E2R7K9 40
type: UnificationXref
id: E2R7K9
db: uniprot

MAPKAPK2 isoform 1
type: ProteinReference
xref: uniprot H2Q104 507
xref: PTHR24349:SF63
organism: Pan troglodytes

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F6UK84 53
xref: PTHR24351:SF48
organism: Xenopus tropicalis

uniprot F7EKJ9 688
type: UnificationXref
id: F7EKJ9
db: uniprot

Ribosomal protein S6 kinase alpha-5
type: ProteinReference
xref: uniprot Q5F3L1 84
xref: PTHR24351:SF115
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
evidence: Evidence 573
evidence: Evidence 574
evidence: Evidence 571
evidence: Evidence 572
xref: uniprot A0A1D5R9U8 570
xref: PTHR44329:SF22
organism: Macaca mulatta

uniprot A0A2I3TPM9 26
type: UnificationXref
id: A0A2I3TPM9
db: uniprot

Platelet-derived growth factor subunit A
type: ProteinReference
xref: uniprot P20033 852
organism: Mus musculus

STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r29
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 1191
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 1192
left: PI3K
interaction type: STATE_TRANSITION
right: PI3K

uniprot Q08DP6 1031
type: UnificationXref
id: Q08DP6
db: uniprot

uniprot E2QYK5 199
type: UnificationXref
id: E2QYK5
db: uniprot

PARTICIPANT STOICHIOMETRY r62 1182
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

RasGAP s107 a63 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P15056 591
type: UnificationXref
id: P15056
db: uniprot

PARTICIPANT STOICHIOMETRY r62 1181
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r62 1184
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Grb2
type: Protein
entity reference: Grb2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r62 1183
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6QZT8 679
xref: PTHR11849:SF195
organism: Monodelphis domestica

Rho GTPase-activating protein 12
type: ProteinReference
xref: uniprot A0A0G2K1Z2 950
organism: Rattus norvegicus

uniprot Q6DGU2 463
type: UnificationXref
id: Q6DGU2
db: uniprot

uniprot G3V813 690
type: UnificationXref
id: G3V813
db: uniprot

uniprot E1BJP4 198
type: UnificationXref
id: E1BJP4
db: uniprot

uniprot Q96A58 467
type: UnificationXref
id: Q96A58
db: uniprot

Raf homolog serine/threonine-protein kinase Raf
type: ProteinReference
xref: PTHR44329:SF193
xref: uniprot P11346 589
organism: Drosophila melanogaster

TRANSPORT_LEFT__PKB-RIGHT__PKB-_r67
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 1152
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 1151
left: PKB
interaction type: TRANSPORT
right: PKB

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: uniprot E2RNA9 219
organism: Canis lupus familiaris

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 573
xref: uniprot P11345 588
xref: PTHR44329:SF22
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r37
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 1148
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 1147
left: PKC
interaction type: STATE_TRANSITION
right: PKC

uniprot A0A3Q1MMD9 860
type: UnificationXref
id: A0A3Q1MMD9
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: c-Myc

GSK3
type: Protein
entity reference: GSK3
feature: ACTIVE 18
feature: GSK3 s103 a145 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PIP2-RIGHT__PIP3-_r30
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 1179
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 1180
left: PIP2
interaction type: STATE_TRANSITION
right: PIP3

uniprot Q15418 81
type: UnificationXref
id: Q15418
db: uniprot

Platelet-derived growth factor receptor alpha
type: ProteinReference
xref: uniprot H2QPH4 513
organism: Pan troglodytes

PDGF receptor A s5 sa3 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.547240302970063

uniprot H2QIH7 280
type: UnificationXref
id: H2QIH7
db: uniprot

ATP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F1PAY3 906
type: UnificationXref
id: F1PAY3
db: uniprot

uniprot P54673 807
type: UnificationXref
id: P54673
db: uniprot

uniprot D4AAT5 36
type: UnificationXref
id: D4AAT5
db: uniprot

Ras
type: Protein
entity reference: Ras
feature: ACTIVE 18
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Cytoplasmic protein
type: ProteinReference
xref: uniprot D4A3M8 273
xref: PTHR19969:SF12
organism: Rattus norvegicus

Platelet-derived growth factor receptor beta
type: ProteinReference
xref: uniprot Q05030 498
organism: Rattus norvegicus

uniprot F7HHY8 506
type: UnificationXref
id: F7HHY8
db: uniprot

Pi
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=ION

Mitogen-activated protein kinase-activated protein kinase 2
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot A0A3Q1M614 502
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot F6TFL4 127
organism: Monodelphis domestica

Protein kinase C
type: ProteinReference
xref: uniprot F6RA79 300
xref: PTHR24356:SF193
organism: Monodelphis domestica

Upstream stimulatory factor 2 isoform 1
type: ProteinReference
xref: uniprot I0FUV2 205
organism: Macaca mulatta

uniprot P52735 837
type: UnificationXref
id: P52735
db: uniprot

PTHR23351:SF4
type: RelationshipXref
id: PTHR23351:SF4
db: PANTHER Family
relationship type: By Homology

uniprot P04085 851
type: UnificationXref
id: P04085
db: uniprot

Ras
type: Protein
entity reference: Ras
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P52332 487
type: UnificationXref
id: P52332
db: uniprot

uniprot O01443 1020
type: UnificationXref
id: O01443
db: uniprot

uniprot P12841 211
type: UnificationXref
id: P12841
db: uniprot

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q04970 449
organism: Rattus norvegicus

PTHR24356:SF163
type: RelationshipXref
id: PTHR24356:SF163
db: PANTHER Family
relationship type: By Homology

uniprot X2JDY8 1065
type: UnificationXref
id: X2JDY8
db: uniprot

PDGF signaling pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__mTOR-_ATP-RIGHT__mTOR-_ADP-_r63
pathway component: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_Pi-_r24
pathway component: STATE_TRANSITION_LEFT__ATP-_ERK-RIGHT__ERK-_ADP-_r23
pathway component: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r21
pathway component: STATE_TRANSITION_LEFT__STAT-RIGHT__STAT-_r78
pathway component: STATE_TRANSITION_LEFT__Nck-RIGHT__Nck-_r71
pathway component: DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r35
pathway component: PHYSICAL_STIMULATION
pathway component: STATE_TRANSITION_LEFT__GTP-_Rho-RIGHT__GDP-_Rho-_r77
pathway component: STATE_TRANSITION_LEFT__GTP-_Ras-RIGHT__GDP-_Ras-_r20
pathway component: STATE_TRANSITION_LEFT__ATP-_p90RSK-RIGHT__p90RSK-_ADP-_r27
pathway component: STATE_TRANSITION_LEFT__c_fos-RIGHT__c_fos-_r50
pathway component: STATE_TRANSITION_LEFT__ATP-_STAT-RIGHT__STAT-_ADP-_r17
pathway component: STATE_TRANSITION_LEFT__Complex__PDGF_receptor_A_PDGF_receptor_B_-RIGHT__Complex__PDGF_receptor_A_PDGF_receptor_B_-_r4
pathway component: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r29
pathway component: TRANSPORT_LEFT__p90RSK-RIGHT__p90RSK-_r66
pathway component: STATE_TRANSITION_LEFT__ATP-_Ets-RIGHT__Ets-_ADP-_r49
pathway component: STATE_TRANSITION_LEFT__GSK3-_ATP-RIGHT__GSK3-_ADP-_r61
pathway component: HETERODIMER_ASSOCIATION_LEFT__PDGF-_PDGF_receptor_B-_PDGF_receptor_A-RIGHT__Complex__PDGF_receptor_A_PDGF_receptor_B_-_r40
pathway component: STATE_TRANSITION_LEFT__ELK-_ATP-RIGHT__ELK-_ADP-_r46
pathway component: STATE_TRANSITION_LEFT__PIP2-RIGHT__PIP3-_r30
pathway component: STATE_TRANSITION_LEFT__c_Myc-_ATP-RIGHT__c_Myc-_ADP-_r48
pathway component: STATE_TRANSITION_LEFT__BAD-_ATP-RIGHT__BAD-_ADP-_r62
pathway component: STATE_TRANSITION_LEFT__Jak-_ATP-RIGHT__Jak-_ADP-_r18
pathway component: STATE_TRANSITION_LEFT__STAT-_ATP-RIGHT__STAT-_ADP-_r80
pathway component: STATE_TRANSITION_LEFT__ATP-_PDK1_2-RIGHT__PDK1_2-_ADP-_r31
pathway component: STATE_TRANSITION_LEFT__ATP-_MNK1_2-RIGHT__MNK1_2-_ADP-_r26
pathway component: STATE_TRANSITION_LEFT__ATP-_Ikk-RIGHT__Ikk-_ADP-_r33
pathway component: TRANSPORT_LEFT__MAPKAPK2-RIGHT__MAPKAPK2-_r65
pathway component: TRANSPORT_LEFT__PKB-RIGHT__PKB-_r67
pathway component: STATE_TRANSITION_LEFT__ATP-_MEK-RIGHT__MEK-_ADP-_r22
pathway component: STATE_TRANSITION_LEFT__PKB-RIGHT__PKB-_Pi-_r34
pathway component: HETERODIMER_ASSOCIATION_LEFT__Shc-_Grb2-_SOS-RIGHT__Complex__Grb2_Shc__SOS_-_r25
pathway component: STATE_TRANSITION_LEFT__RasGAP-RIGHT__RasGAP-_r69
pathway component: TRANSPORT_LEFT__ERK-RIGHT__ERK-_r60
pathway component: STATE_TRANSITION_LEFT__ATP-_MAPKAPK2-RIGHT__MAPKAPK2-_ADP-_r28
pathway component: STATE_TRANSITION_LEFT__IP3_receptor-RIGHT__IP3_receptor-_r82
pathway component: STATE_TRANSITION_LEFT__Vav-RIGHT__Vav-_r73
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r38
pathway component: STATE_TRANSITION_LEFT__ATP-_PKB-RIGHT__PKB-_ADP-_r32
pathway component: TRANSPORT_LEFT__STAT-RIGHT__STAT-_r79
pathway component: STATE_TRANSITION_LEFT__PLCgamma-RIGHT__PLCgamma-_r36
pathway component: STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_r51
pathway component: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r37
pathway component: STATE_TRANSITION_LEFT__c_Jun-_ATP-RIGHT__c_Jun-_ADP-_r58
xref: PANTHER Pathway P00047 1
comment: MODEL_NOTES=Panther Pathway: P00047 Platelet derived growth factor (PDGF) plays a critical role in cellular proliferation and development. PDGF signaling is initiated upon binding of PDGF to the PDGF receptor complex. The PDGF receptors belong to the family of receptor protein tyrosine kinases (RPTK). Upon ligand binding, the receptors chains trans-phosphorylate each other, resulting in recruitment of adaptor molecules via SH2 domains and leading to phosphorylation of other cellular proteins. Medline=1339664 Medline=7888178 Medline=973976 Website=http://www.biocarta.com/pathfiles/h_pdgfPathway.asp PMID: 1339664 PMID: 7888178 PMID: 973976

mTOR
type: Protein
entity reference: mTOR
feature: mTOR s65 a152 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Ras-like protein rasD
type: ProteinReference
xref: uniprot P03967 434
xref: PTHR24070:SF418
organism: Dictyostelium discoideum

SRF
type: Protein
entity reference: SRF
feature: SRF s101 a123 rs1
feature: ACTIVE 18
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P54675 809
type: UnificationXref
id: P54675
db: uniprot

PARTICIPANT STOICHIOMETRY r24 1215
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 1214
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ATP-_PDK1_2-RIGHT__PDK1_2-_ADP-_r31
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 1171
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 1172
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 1174
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 1173
left: PDK1/2
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: PDK1/2

PARTICIPANT STOICHIOMETRY r24 1213
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

SLIT-ROBO Rho GTPase activating protein 1
type: ProteinReference
xref: uniprot H2R1I1 1014
organism: Pan troglodytes

GDP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR24057:SF34
type: RelationshipXref
id: PTHR24057:SF34
db: PANTHER Family
relationship type: By Homology

ETS-like protein pointed
type: ProteinReference
xref: PTHR11849:SF289
xref: uniprot P51023 713
organism: Drosophila melanogaster

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot Q07890 532
xref: PTHR23113:SF150
organism: Homo sapiens

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot Q1LYG2 595
xref: PTHR44329:SF47
organism: Danio rerio

SLIT-ROBO Rho GTPase-activating protein 2 isoform a
type: ProteinReference
xref: uniprot G7MER6 1006
organism: Macaca mulatta

uniprot Q6Q7I7 855
type: UnificationXref
id: Q6Q7I7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1M864 238
organism: Bos taurus

PKB
type: Protein
entity reference: PKB
feature: ACTIVE 18
feature: PKB s34 a101 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P62994 255
type: UnificationXref
id: P62994
db: uniprot

PTHR24057:SF36
type: RelationshipXref
id: PTHR24057:SF36
db: PANTHER Family
relationship type: By Homology

uniprot K7D2P2 206
type: UnificationXref
id: K7D2P2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLCgamma-RIGHT__PLCgamma-_r36
controller: Complex (PDGF receptor A/PDGF receptor B)

uniprot F7F3S0 780
type: UnificationXref
id: F7F3S0
db: uniprot

uniprot A8X0X5 398
type: UnificationXref
id: A8X0X5
db: uniprot

uniprot O14920 225
type: UnificationXref
id: O14920
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot E1BLQ5 38
organism: Bos taurus

Mitogen-activated protein kinase 6
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot Q5F3W3 168
organism: Gallus gallus

AGAP011463-PA
type: ProteinReference
xref: uniprot Q7Q334 1078
organism: Anopheles gambiae

Phosphoinositide-3-kinase regulatory subunit 3
type: ProteinReference
xref: uniprot A0A2I3RH39 747
xref: PTHR10155:SF2
organism: Pan troglodytes

ncbitaxon 321614 124
type: UnificationXref
id: 321614
db: ncbitaxon

uniprot E2RP04 43
type: UnificationXref
id: E2RP04
db: uniprot

uniprot O95238 701
type: UnificationXref
id: O95238
db: uniprot

uniprot Q9Y0A1 567
type: UnificationXref
id: Q9Y0A1
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F1PAY3 906
xref: PTHR11801:SF48
organism: Canis lupus familiaris

uniprot F6TD14 769
type: UnificationXref
id: F6TD14
db: uniprot

E74-like ETS transcription factor 5
type: ProteinReference
xref: PTHR11849:SF15
xref: uniprot D4A3N9 667
organism: Rattus norvegicus

uniprot F1PUX3 984
type: UnificationXref
id: F1PUX3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A2I3SED2 322
xref: PTHR10194:SF4
organism: Pan troglodytes

uniprot Q5XIT5 729
type: UnificationXref
id: Q5XIT5
db: uniprot

Mitogen-activated protein kinase 6
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot G5E577 141
organism: Bos taurus

PTHR24057:SF40
type: RelationshipXref
id: PTHR24057:SF40
db: PANTHER Family
relationship type: By Homology

uniprot X2JCF3 1064
type: UnificationXref
id: X2JCF3
db: uniprot

PTHR24057:SF41
type: RelationshipXref
id: PTHR24057:SF41
db: PANTHER Family
relationship type: By Homology

PTHR24057:SF42
type: RelationshipXref
id: PTHR24057:SF42
db: PANTHER Family
relationship type: By Homology

uniprot A0A0G2JWE9 643
type: UnificationXref
id: A0A0G2JWE9
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 288
xref: uniprot F6TJU6 287
xref: PTHR24349:SF114
organism: Macaca mulatta

ETS homologous factor
type: ProteinReference
xref: PTHR11849:SF171
xref: uniprot O70273 700
organism: Mus musculus

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 11

Rho GTPase-activating protein 26
type: ProteinReference
xref: uniprot Q5ZMW5 1039
xref: PTHR12552:SF4
organism: Gallus gallus

uniprot F1P859 520
type: UnificationXref
id: F1P859
db: uniprot

PTHR24057:SF48
type: RelationshipXref
id: PTHR24057:SF48
db: PANTHER Family
relationship type: By Homology

PTHR13715:SF87
type: RelationshipXref
id: PTHR13715:SF87
db: PANTHER Family
relationship type: By Homology

Protein son of sevenless
type: ProteinReference
xref: uniprot P26675 529
xref: PTHR23113:SF341
organism: Drosophila melanogaster

Mitogen-activated protein kinase 15
type: ProteinReference
xref: PTHR24055:SF79
xref: uniprot Q80Y86 177
organism: Mus musculus

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P04627 585
xref: PTHR44329:SF55
organism: Mus musculus

uniprot Q6PC73 265
type: UnificationXref
id: Q6PC73
db: uniprot

uniprot A8WTA3 964
type: UnificationXref
id: A8WTA3
db: uniprot

uniprot Q62077 872
type: UnificationXref
id: Q62077
db: uniprot

uniprot Q9UNA1 1061
type: UnificationXref
id: Q9UNA1
db: uniprot

ETS-related transcription factor Elf-1
type: ProteinReference
xref: uniprot Q60775 731
xref: PTHR11849:SF156
organism: Mus musculus

Rho GTPase activating protein 5
type: ProteinReference
xref: uniprot E2RED4 976
organism: Canis lupus familiaris

STAT
type: Complex
component stoichiometry: STAT s123 a173 STOICHIOMETRY ID COMPLEX
component: STAT
feature: ACTIVE 18
cellular location: nucleus

STAT
type: Complex
component stoichiometry: STAT s122 a171 STOICHIOMETRY ID COMPLEX
component: STAT
feature: ACTIVE 18
cellular location: cytoplasm

PTHR24057:SF51
type: RelationshipXref
id: PTHR24057:SF51
db: PANTHER Family
relationship type: By Homology

uniprot F1N7N8 328
type: UnificationXref
id: F1N7N8
db: uniprot

STAT
type: Complex
component stoichiometry: STAT s127 a172 STOICHIOMETRY ID COMPLEX
component: STAT
feature: ACTIVE 18
cellular location: nucleus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A1D5R9X3 897
xref: PTHR11801:SF18
organism: Macaca mulatta

PTHR24070:SF418
type: RelationshipXref
id: PTHR24070:SF418
db: PANTHER Family
relationship type: By Homology

3-phosphoinositide dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot F1Q2Y3 625
organism: Canis lupus familiaris

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 572
xref: uniprot P05625 586
xref: PTHR44329:SF22
organism: Gallus gallus

Ras-related protein Rab-11B
type: ProteinReference
xref: uniprot O35509 428
organism: Rattus norvegicus

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05627 621
organism: Mus musculus

Protein C-ets-1
type: ProteinReference
xref: uniprot P27577 706
xref: PTHR11849:SF209
organism: Mus musculus

Shaggy-related protein kinase epsilon
type: ProteinReference
xref: uniprot Q8VZD5 374
xref: PTHR24057:SF36
organism: Arabidopsis thaliana

c-fos
type: Protein
entity reference: c-fos
feature: ACTIVE 18
feature: c fos s98 a117 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot E2R9L4 118
organism: Canis lupus familiaris

Platelet-derived growth factor receptor beta
type: ProteinReference
xref: uniprot P05622 496
organism: Mus musculus

Ribosomal protein S6 kinase alpha-2
type: ProteinReference
xref: uniprot Q15349 80
xref: PTHR24351:SF213
organism: Homo sapiens

uniprot Q13017 1032
type: UnificationXref
id: Q13017
db: uniprot

uniprot E1B8P9 115
type: UnificationXref
id: E1B8P9
db: uniprot

uniprot F7C2C6 134
type: UnificationXref
id: F7C2C6
db: uniprot

uniprot H9FYU7 527
type: UnificationXref
id: H9FYU7
db: uniprot

Serine/threonine-protein kinase ksg1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q12701 631
organism: Schizosaccharomyces pombe

BAD
type: Protein
feature: BAD s54 a151 rs1
feature: ACTIVE 18
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

ERK s27 a72 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F6UNV6 54
type: UnificationXref
id: F6UNV6
db: uniprot

uniprot F1PZ82 504
type: UnificationXref
id: F1PZ82
db: uniprot

uniprot P01100 208
type: UnificationXref
id: P01100
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF110
xref: uniprot A8XFY3 32
organism: Caenorhabditis briggsae

PTHR24057:SF60
type: RelationshipXref
id: PTHR24057:SF60
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot F7DNM3 329
organism: Macaca mulatta

Serum response factor
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot P11831 210
organism: Homo sapiens

Grb2 s9 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

uniprot Q9Z1L0 822
type: UnificationXref
id: Q9Z1L0
db: uniprot

uniprot Q9VR61 96
type: UnificationXref
id: Q9VR61
db: uniprot

Serine/threonine-protein kinase psk1
type: ProteinReference
xref: uniprot Q12706 78
organism: Schizosaccharomyces pombe

PTHR24070:SF420
type: RelationshipXref
id: PTHR24070:SF420
db: PANTHER Family
relationship type: By Homology

uniprot B2RYD8 660
type: UnificationXref
id: B2RYD8
db: uniprot

uniprot O55033 282
type: UnificationXref
id: O55033
db: uniprot

PTHR24070:SF423
type: RelationshipXref
id: PTHR24070:SF423
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F1PUX3 984
organism: Canis lupus familiaris

uniprot Q08012 256
type: UnificationXref
id: Q08012
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTP-_Rho-RIGHT__GDP-_Rho-_r77
controller: Vav

uniprot F6TJU6 287
type: UnificationXref
id: F6TJU6
db: uniprot

uniprot P45983 154
type: UnificationXref
id: P45983
db: uniprot

uniprot F1NE37 846
type: UnificationXref
id: F1NE37
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot O35904 793
organism: Mus musculus

ETS transcription factor ERG
type: ProteinReference
xref: uniprot F6WHZ1 681
xref: PTHR11849:SF216
organism: Ornithorhynchus anatinus

uniprot O17788 426
type: UnificationXref
id: O17788
db: uniprot

SLIT-ROBO Rho GTPase activating protein 3
type: ProteinReference
xref: uniprot F1PJZ0 983
organism: Canis lupus familiaris

uniprot H2QW34 224
type: UnificationXref
id: H2QW34
db: uniprot

PARTICIPANT STOICHIOMETRY r48 1118
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot F6XTS0 10
type: UnificationXref
id: F6XTS0
db: uniprot

PARTICIPANT STOICHIOMETRY r48 1119
type: Stoichiometry
physical entity: c-Myc
stoichiometric coefficient: 1.0

uniprot F6TAF3 221
type: UnificationXref
id: F6TAF3
db: uniprot

PARTICIPANT STOICHIOMETRY r48 1117
type: Stoichiometry
physical entity: c-Myc
stoichiometric coefficient: 1.0

STAT
type: Protein
entity reference: STAT
feature: STAT s11 a53 rs1
feature: STAT s11 a53 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

P01175
type: UnificationXref
id: P01175
db: PANTHER Pathway Component

P01173
type: UnificationXref
id: P01173
db: PANTHER Pathway Component

P01174
type: UnificationXref
id: P01174
db: PANTHER Pathway Component

uniprot A0A1D5R9X3 897
type: UnificationXref
id: A0A1D5R9X3
db: uniprot

P01171
type: UnificationXref
id: P01171
db: PANTHER Pathway Component

uniprot H2Q3E6 692
type: UnificationXref
id: H2Q3E6
db: uniprot

P01172
type: UnificationXref
id: P01172
db: PANTHER Pathway Component

P01170
type: UnificationXref
id: P01170
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Q2Q1 985
xref: PTHR23176:SF108
organism: Monodelphis domestica

BAD s61 a148 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR11849:SF31
type: RelationshipXref
id: PTHR11849:SF31
db: PANTHER Family
relationship type: By Homology

PTHR11849:SF30
type: RelationshipXref
id: PTHR11849:SF30
db: PANTHER Family
relationship type: By Homology

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r38
control type: ACTIVATION
controller: IP3 receptor

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HS52 247
organism: Macaca mulatta

Rho GTPase activating protein 26 (Predicted)
type: ProteinReference
xref: PTHR12552:SF4
xref: uniprot D3ZMS4 969
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5ZJ46 730
xref: PTHR11849:SF195
organism: Gallus gallus

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot D4A3T0 517
xref: PTHR23113:SF168
organism: Rattus norvegicus

PTHR10336:SF25
type: RelationshipXref
id: PTHR10336:SF25
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot A0A1D5QUZ8 104
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

MAPKAPK2
type: ProteinReference
xref: P01157
standard name: Mitogen-activated protein kinase-activated protein kinase 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.MAPKAPK2
comment: ENTITY_REFERENCE_NOTES= Long Name: MAPKAPK2 Synonym: MAPKAP kinase 2,MAPKAPK2 Accession: P01157
member entity reference: Mitogen-activated protein kinase kinase 2
member entity reference: Mitogen-activated protein kinase-activated protein kinase 2
member entity reference: MAP kinase-activated protein kinase 2
member entity reference: MAPKAPK2 isoform 1
member entity reference: Uncharacterized protein

P01167
type: UnificationXref
id: P01167
db: PANTHER Pathway Component

P01168
type: UnificationXref
id: P01168
db: PANTHER Pathway Component

P01169
type: UnificationXref
id: P01169
db: PANTHER Pathway Component

uniprot Q61411 462
type: UnificationXref
id: Q61411
db: uniprot

P01162
type: UnificationXref
id: P01162
db: PANTHER Pathway Component

P01163
type: UnificationXref
id: P01163
db: PANTHER Pathway Component

Signal transducer and activator of transcription 1-alpha/beta
type: ProteinReference
xref: uniprot P42224 923
xref: PTHR11801:SF18
organism: Homo sapiens

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot E2RIF9 760
xref: PTHR10048:SF7
organism: Canis lupus familiaris

P01164
type: UnificationXref
id: P01164
db: PANTHER Pathway Component

P01165
type: UnificationXref
id: P01165
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r48 1120
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

AGAP002219-PA
type: ProteinReference
xref: uniprot Q7QK91 464
xref: PTHR24070:SF420
organism: Anopheles gambiae

P01160
type: UnificationXref
id: P01160
db: PANTHER Pathway Component

P01161
type: UnificationXref
id: P01161
db: PANTHER Pathway Component

uniprot H2QR74 332
type: UnificationXref
id: H2QR74
db: uniprot

uniprot Q9LIS6 379
type: UnificationXref
id: Q9LIS6
db: uniprot

uniprot A2T762 658
type: UnificationXref
id: A2T762
db: uniprot

uniprot Q3MHP2 457
type: UnificationXref
id: Q3MHP2
db: uniprot

MAPK6 isoform 1
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot H2Q9G3 142
organism: Pan troglodytes

uniprot F7EEN8 999
type: UnificationXref
id: F7EEN8
db: uniprot

Rho GTPase-activating protein 1
type: ProteinReference
xref: uniprot Q5FWK3 1037
xref: PTHR45808:SF6
organism: Mus musculus

uniprot Q90837 735
type: UnificationXref
id: Q90837
db: uniprot

P01159
type: UnificationXref
id: P01159
db: PANTHER Pathway Component

uniprot O70273 700
type: UnificationXref
id: O70273
db: uniprot

uniprot E1BKE7 544
type: UnificationXref
id: E1BKE7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot F1P1X4 547
organism: Gallus gallus

Signal transducer and activator of transcription 5B
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot P42232 930
organism: Mus musculus

PTHR11849:SF15
type: RelationshipXref
id: PTHR11849:SF15
db: PANTHER Family
relationship type: By Homology

Signal transducer and activator of transcription 5A
type: ProteinReference
xref: PTHR11801:SF47
xref: uniprot P42230 929
organism: Mus musculus

PTHR11849:SF13
type: RelationshipXref
id: PTHR11849:SF13
db: PANTHER Family
relationship type: By Homology

uniprot O75582 70
type: UnificationXref
id: O75582
db: uniprot

uniprot Q7ZVS9 890
type: UnificationXref
id: Q7ZVS9
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A0A2I3SHP7 859
xref: PTHR10336:SF25
organism: Pan troglodytes

Platelet-derived growth factor receptor alpha
type: ProteinReference
xref: uniprot P26618 516
organism: Mus musculus

PTHR11849:SF10
type: RelationshipXref
id: PTHR11849:SF10
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3TNY5 898
type: UnificationXref
id: A0A2I3TNY5
db: uniprot

uniprot Q94IZ2 376
type: UnificationXref
id: Q94IZ2
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q8UUX0 320
xref: PTHR24356:SF176
organism: Danio rerio

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 33

Uncharacterized protein
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q5F3U4 632
organism: Gallus gallus

Ras guanine nucleotide exchange factor R
type: ProteinReference
xref: uniprot Q8SSQ0 540
organism: Dictyostelium discoideum

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot F7EP57 779
organism: Macaca mulatta

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 83

SLIT-ROBO Rho GTPase activating protein 1
type: ProteinReference
xref: uniprot F1MFS4 979
organism: Bos taurus

Signal transducer and activator of transcription 5A
type: ProteinReference
xref: PTHR11801:SF47
xref: uniprot P42229 928
organism: Homo sapiens

ncbitaxon 7668 391
type: UnificationXref
id: 7668
db: ncbitaxon

Signal transducer and activator of transcription 3
type: ProteinReference
xref: uniprot P42227 926
xref: PTHR11801:SF2
organism: Mus musculus

uniprot Q7QCN5 338
type: UnificationXref
id: Q7QCN5
db: uniprot

Jak
type: Protein
entity reference: Jak
feature: Jak s111 a48 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Signal transducer and activator of transcription 4
type: ProteinReference
xref: PTHR11801:SF19
xref: uniprot P42228 927
organism: Mus musculus

Signal transducer and activator of transcription 1
type: ProteinReference
xref: uniprot P42225 924
xref: PTHR11801:SF18
organism: Mus musculus

Signal transducer and activator of transcription 6
type: ProteinReference
xref: PTHR11801:SF48
xref: uniprot P42226 925
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q8BTI9 817
xref: PTHR10048:SF33
organism: Mus musculus

uniprot A0A2I3TRE4 900
type: UnificationXref
id: A0A2I3TRE4
db: uniprot

uniprot Q07889 531
type: UnificationXref
id: Q07889
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF19
xref: uniprot A0A1D5QTL2 896
organism: Macaca mulatta

uniprot Q16659 160
type: UnificationXref
id: Q16659
db: uniprot

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 573
evidence: Evidence 574
evidence: Evidence 571
evidence: Evidence 572
xref: PTHR44329:SF22
xref: uniprot E2REI6 579
organism: Canis lupus familiaris

Ikk
type: Protein
entity reference: Ikk
feature: Ikk s64 a97 rs1
feature: ACTIVE 18
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Son of sevenless homolog 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot Q07889 531
organism: Homo sapiens

uniprot D4A6C5 973
type: UnificationXref
id: D4A6C5
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF213
xref: uniprot F1M7N7 45
organism: Rattus norvegicus

uniprot D3ZU63 970
type: UnificationXref
id: D3ZU63
db: uniprot

PTHR11849:SF21
type: RelationshipXref
id: PTHR11849:SF21
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6S443 412
organism: Macaca mulatta

uniprot E2R9T4 671
type: UnificationXref
id: E2R9T4
db: uniprot

uniprot Q95115 943
type: UnificationXref
id: Q95115
db: uniprot

uniprot O93599 921
type: UnificationXref
id: O93599
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot O08908 792
organism: Mus musculus

uniprot A0A3Q1LXK8 29
type: UnificationXref
id: A0A3Q1LXK8
db: uniprot

Rho GTPase-activating protein 8
type: ProteinReference
xref: uniprot Q9CXP4 1059
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR13168:SF0
xref: uniprot J9P9G9 880
organism: Canis lupus familiaris

uniprot Q8W4J2 179
type: UnificationXref
id: Q8W4J2
db: uniprot

uniprot H2Q4L7 1010
type: UnificationXref
id: H2Q4L7
db: uniprot

ERG isoform 10
type: ProteinReference
xref: PTHR11849:SF216
xref: uniprot A0A2I3SPS3 650
organism: Pan troglodytes

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot E2R2N2 117
organism: Canis lupus familiaris

uniprot P24583 307
type: UnificationXref
id: P24583
db: uniprot

uniprot H2Q3I0 1009
type: UnificationXref
id: H2Q3I0
db: uniprot

Ets variant 2
type: ProteinReference
xref: PTHR11849:SF206
xref: uniprot D3ZEY9 664
organism: Rattus norvegicus

uniprot Q9CX99 268
type: UnificationXref
id: Q9CX99
db: uniprot

uniprot Q8C0D4 1051
type: UnificationXref
id: Q8C0D4
db: uniprot

GTP-binding protein
type: ProteinReference
xref: uniprot O93468 429
xref: PTHR24072:SF0
organism: Gallus gallus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F6UJK9 911
xref: PTHR11801:SF18
organism: Xenopus tropicalis

uniprot Q5ANK2 311
type: UnificationXref
id: Q5ANK2
db: uniprot

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF16
xref: uniprot F7GD33 278
organism: Monodelphis domestica

ncbitaxon 9598 25
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot Q5ZMM3 1038
type: UnificationXref
id: Q5ZMM3
db: uniprot

uniprot Q19370 1033
type: UnificationXref
id: Q19370
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: uniprot Q63789 813
xref: PTHR10155:SF2
organism: Rattus norvegicus

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: uniprot Q63788 812
xref: PTHR10155:SF1
organism: Rattus norvegicus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P32871 801
organism: Bos taurus

uniprot A0A1D5PED3 644
type: UnificationXref
id: A0A1D5PED3
db: uniprot

uniprot H2QSU0 554
type: UnificationXref
id: H2QSU0
db: uniprot

uniprot E2QVF3 116
type: UnificationXref
id: E2QVF3
db: uniprot

PTHR24055:SF222
type: RelationshipXref
id: PTHR24055:SF222
db: PANTHER Family
relationship type: By Homology

uniprot Q9YH61 388
type: UnificationXref
id: Q9YH61
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45808:SF6
xref: uniprot F6RWK1 990
organism: Bos taurus

STAT s122 a171 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

PKC s117 a108 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 440

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot E1BE66 757
organism: Bos taurus

uniprot D3ZWM8 666
type: UnificationXref
id: D3ZWM8
db: uniprot

uniprot Q9R0Z9 1060
type: UnificationXref
id: Q9R0Z9
db: uniprot

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot E2RB53 348
organism: Canis lupus familiaris

Shaggy-related protein kinase theta
type: ProteinReference
xref: uniprot Q96287 377
xref: PTHR24057:SF60
organism: Arabidopsis thaliana

PTHR11801:SF19
type: RelationshipXref
id: PTHR11801:SF19
db: PANTHER Family
relationship type: By Homology

PTHR11801:SF18
type: RelationshipXref
id: PTHR11801:SF18
db: PANTHER Family
relationship type: By Homology

uniprot F6YLW2 131
type: UnificationXref
id: F6YLW2
db: uniprot

GTP binding protein
type: ProteinReference
xref: uniprot G5EBK8 421
organism: Caenorhabditis elegans

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ELK-_ATP-RIGHT__ELK-_ADP-_r46
controller: ERK

uniprot F6XRU8 879
type: UnificationXref
id: F6XRU8
db: uniprot

PANTHER Pathway P00047 1
type: UnificationXref
id: P00047
db: PANTHER Pathway

Ikk
type: ProteinReference
xref: P01146
standard name: cytokine-responsive IkappaB kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.Ikk
comment: ENTITY_REFERENCE_NOTES= Long Name: cytokine-responsive IkappaB kinase Synonym: IKK,IkappaB kinase Accession: P01146
member entity reference: Inhibitor of nuclear factor kappa B kinase subunit beta
member entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta
member entity reference: Elongator complex protein 1
member entity reference: Inhibitor of nuclear factor kappa-B kinase subunit alpha
member entity reference: Conserved helix-loop-helix ubiquitous kinase
member entity reference: Uncharacterized protein

uniprot F7A818 552
type: UnificationXref
id: F7A818
db: uniprot

PTHR12552:SF4
type: RelationshipXref
id: PTHR12552:SF4
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot C8V7D1 113
organism: Emericella nidulans

PTHR12552:SF5
type: RelationshipXref
id: PTHR12552:SF5
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r36 1149
type: Stoichiometry
physical entity: PLCgamma
stoichiometric coefficient: 1.0

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q60823 319
organism: Mus musculus

uniprot P83101 366
type: UnificationXref
id: P83101
db: uniprot

uniprot F6RYL1 619
type: UnificationXref
id: F6RYL1
db: uniprot

PARTICIPANT STOICHIOMETRY r67 1151
type: Stoichiometry
physical entity: PKB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r67 1152
type: Stoichiometry
physical entity: PKB
stoichiometric coefficient: 1.0

SLIT-ROBO Rho GTPase-activating protein 3
type: ProteinReference
xref: uniprot Q812A2 1049
organism: Mus musculus

uniprot A0A1D5PQJ2 952
type: UnificationXref
id: A0A1D5PQJ2
db: uniprot

Vav
type: Protein
entity reference: Vav
feature: ACTIVE 18
feature: Vav s119 a162 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR23113:SF168
type: RelationshipXref
id: PTHR23113:SF168
db: PANTHER Family
relationship type: By Homology

Proline-rich protein 5
type: ProteinReference
xref: uniprot Q812A5 1050
organism: Mus musculus

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot P11881 557
organism: Mus musculus

uniprot Q24324 613
type: UnificationXref
id: Q24324
db: uniprot

uniprot O15530 626
type: UnificationXref
id: O15530
db: uniprot

uniprot F6VH29 994
type: UnificationXref
id: F6VH29
db: uniprot

GAB1 isoform 1
type: ProteinReference
xref: uniprot H2QQ79 249
organism: Pan troglodytes

uniprot P50904 336
type: UnificationXref
id: P50904
db: uniprot

Protein FEV
type: ProteinReference
xref: PTHR11849:SF203
xref: uniprot Q99581 736
organism: Homo sapiens

uniprot F7FRY0 62
type: UnificationXref
id: F7FRY0
db: uniprot

uniprot P29994 559
type: UnificationXref
id: P29994
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YCI3 524
xref: PTHR23113:SF150
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r36 1150
type: Stoichiometry
physical entity: PLCgamma
stoichiometric coefficient: 1.0

uniprot Q61831 173
type: UnificationXref
id: Q61831
db: uniprot

PTHR24349:SF63
type: RelationshipXref
id: PTHR24349:SF63
db: PANTHER Family
relationship type: By Homology

Proto-oncogene c-Fos
type: ProteinReference
xref: uniprot P12841 211
xref: PTHR23351:SF4
organism: Rattus norvegicus

uniprot Q9JHG7 821
type: UnificationXref
id: Q9JHG7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6T0E0 991
xref: PTHR45808:SF6
organism: Macaca mulatta

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot P45983 154
xref: PTHR24055:SF222
organism: Homo sapiens

GRB2-associated-binding protein 2
type: ProteinReference
xref: uniprot Q9UQC2 271
organism: Homo sapiens

Glycogen synthase kinase-3 beta isoform 1
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot H9EPM1 354
organism: Macaca mulatta

uniprot D3ZHH8 197
type: UnificationXref
id: D3ZHH8
db: uniprot

uniprot P54674 808
type: UnificationXref
id: P54674
db: uniprot

PARTICIPANT STOICHIOMETRY r66 1159
type: Stoichiometry
physical entity: p90RSK
stoichiometric coefficient: 1.0

uniprot P14056 590
type: UnificationXref
id: P14056
db: uniprot

STATE_TRANSITION_LEFT__STAT-RIGHT__STAT-_r78
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 1126
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 1125
left: STAT
interaction type: STATE_TRANSITION
right: STAT

uniprot G5E577 141
type: UnificationXref
id: G5E577
db: uniprot

GRB2-associated-binding protein 1
type: ProteinReference
xref: uniprot Q13480 257
organism: Homo sapiens

uniprot F7AN37 245
type: UnificationXref
id: F7AN37
db: uniprot

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PR50 125
organism: Macaca mulatta

Rho GTPase-activating protein 7
type: ProteinReference
xref: uniprot Q9R0Z9 1060
organism: Mus musculus

PTHR24055:SF200
type: RelationshipXref
id: PTHR24055:SF200
db: PANTHER Family
relationship type: By Homology

uniprot D4AE24 37
type: UnificationXref
id: D4AE24
db: uniprot

ncbitaxon 9615 41
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot P01112 431
type: UnificationXref
id: P01112
db: uniprot

PTHR11801:SF39
type: RelationshipXref
id: PTHR11801:SF39
db: PANTHER Family
relationship type: By Homology

E74 like ETS transcription factor 1
type: ProteinReference
xref: uniprot E2R9T4 671
xref: PTHR11849:SF156
organism: Canis lupus familiaris

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P14056 590
xref: PTHR44329:SF55
organism: Rattus norvegicus

uniprot Q6ZQ82 1045
type: UnificationXref
id: Q6ZQ82
db: uniprot

uniprot D4A3N9 667
type: UnificationXref
id: D4A3N9
db: uniprot

Guanine nucleotide exchange factor VAV2 isoform 1
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot I2CU78 834
organism: Macaca mulatta

Shc s13 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Shc
stoichiometric coefficient: 1.0

GRB2-related adaptor protein
type: ProteinReference
xref: PTHR46037:SF2
xref: uniprot Q4KM68 260
organism: Rattus norvegicus

uniprot P18654 74
type: UnificationXref
id: P18654
db: uniprot

uniprot Q8GW13 891
type: UnificationXref
id: Q8GW13
db: uniprot

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 381

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F1QWX8 477
xref: PTHR45807:SF2
organism: Danio rerio

uniprot D3Z8E0 34
type: UnificationXref
id: D3Z8E0
db: uniprot

uniprot Q5F352 460
type: UnificationXref
id: Q5F352
db: uniprot

PARTICIPANT STOICHIOMETRY r66 1160
type: Stoichiometry
physical entity: p90RSK
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F1QWX2 908
xref: PTHR11801:SF39
organism: Danio rerio

uniprot Q66JE6 616
type: UnificationXref
id: Q66JE6
db: uniprot

PTHR11801:SF41
type: RelationshipXref
id: PTHR11801:SF41
db: PANTHER Family
relationship type: By Homology

PTHR11801:SF47
type: RelationshipXref
id: PTHR11801:SF47
db: PANTHER Family
relationship type: By Homology

uniprot G3V9V2 691
type: UnificationXref
id: G3V9V2
db: uniprot

GTPase HRas
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot Q61411 462
organism: Mus musculus

uniprot P17325 622
type: UnificationXref
id: P17325
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot P08556 435
xref: PTHR24070:SF189
organism: Mus musculus

Platelet-derived growth factor subunit B
type: ProteinReference
xref: uniprot P31240 854
organism: Mus musculus

uniprot F7D094 277
type: UnificationXref
id: F7D094
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F6QE96 315
organism: Macaca mulatta

Phosphoinositide-3-kinase regulatory subunit 2
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot H2QFS6 787
organism: Pan troglodytes

uniprot Q9UA62 634
type: UnificationXref
id: Q9UA62
db: uniprot

Ribosomal protein S6 kinase alpha-2
type: ProteinReference
xref: PTHR24351:SF213
xref: uniprot Q9WUT3 97
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1PRG4 314
xref: PTHR24356:SF176
organism: Canis lupus familiaris

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot F6UNV6 54
organism: Macaca mulatta

uniprot F1MYM3 763
type: UnificationXref
id: F1MYM3
db: uniprot

ETS domain-containing protein Elk-4
type: ProteinReference
xref: uniprot P28324 14
xref: PTHR11849:SF21
organism: Homo sapiens

Rho GTPase-activating protein 4
type: ProteinReference
xref: uniprot B1AUY3 966
organism: Mus musculus

Rho GTPase activating protein 4, isoform CRA_a
type: ProteinReference
xref: uniprot A0A0G2JVF0 949
organism: Rattus norvegicus

uniprot F1PPW0 1067
type: UnificationXref
id: F1PPW0
db: uniprot

PTHR10048:SF7
type: RelationshipXref
id: PTHR10048:SF7
db: PANTHER Family
relationship type: By Homology

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r38
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 1144
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 1143
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P20444 306
organism: Mus musculus

PTHR11801:SF2
type: RelationshipXref
id: PTHR11801:SF2
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase PKH3
type: ProteinReference
xref: uniprot Q03306 628
organism: Saccharomyces cerevisiae

MAPKAPK2
type: Protein
entity reference: MAPKAPK2
feature: MAPKAPK2 s85 a85 rs1
feature: ACTIVE 18
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Ras GTPase-activating protein 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot F1N7N8 328
organism: Bos taurus

SLIT-ROBO Rho GTPase-activating protein 1
type: ProteinReference
xref: uniprot Q7Z6B7 1047
organism: Homo sapiens

uniprot F6Y6B5 997
type: UnificationXref
id: F6Y6B5
db: uniprot

PARTICIPANT STOICHIOMETRY r82 1232
type: Stoichiometry
physical entity: IP3 receptor
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r82 1233
type: Stoichiometry
physical entity: IP3 receptor
stoichiometric coefficient: 1.0

uniprot D3ZMS4 969
type: UnificationXref
id: D3ZMS4
db: uniprot

uniprot F6ZCW7 551
type: UnificationXref
id: F6ZCW7
db: uniprot

Mitogen-activated protein kinase 19
type: ProteinReference
xref: uniprot Q9LUC3 184
xref: PTHR24055:SF200
organism: Arabidopsis thaliana

WW domain-containing protein tag-325
type: ProteinReference
xref: PTHR23176:SF113
xref: uniprot P46941 1026
organism: Caenorhabditis elegans

uniprot F1MX38 905
type: UnificationXref
id: F1MX38
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot H2QKD0 866
organism: Pan troglodytes

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot E2RB82 902
organism: Canis lupus familiaris

DNA-binding protein D-ETS-6
type: ProteinReference
xref: uniprot P29776 707
xref: PTHR11849:SF204
organism: Drosophila melanogaster

PTHR13715:SF52
type: RelationshipXref
id: PTHR13715:SF52
db: PANTHER Family
relationship type: By Homology

PTHR13715:SF51
type: RelationshipXref
id: PTHR13715:SF51
db: PANTHER Family
relationship type: By Homology

uniprot F7BXX1 639
type: UnificationXref
id: F7BXX1
db: uniprot

uniprot F1PHH8 676
type: UnificationXref
id: F1PHH8
db: uniprot

PTHR13715:SF53
type: RelationshipXref
id: PTHR13715:SF53
db: PANTHER Family
relationship type: By Homology

uniprot F6R543 548
type: UnificationXref
id: F6R543
db: uniprot

Protein kinase C-like 2
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P36583 309
organism: Schizosaccharomyces pombe

uniprot F7EH19 137
type: UnificationXref
id: F7EH19
db: uniprot

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot Q9WV60 385
organism: Mus musculus

StAR-related lipid transfer protein 8
type: ProteinReference
xref: uniprot Q8K031 1053
xref: PTHR12659:SF3
organism: Mus musculus

RAB11B, member RAS oncogene family
type: ProteinReference
xref: uniprot A0A2I3RSY4 392
organism: Pan troglodytes

uniprot E9PYG6 326
type: UnificationXref
id: E9PYG6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NE37 846
organism: Gallus gallus

GRB2-related adapter protein 2
type: ProteinReference
xref: PTHR46037:SF3
xref: uniprot O75791 251
organism: Homo sapiens

uniprot F7EI48 138
type: UnificationXref
id: F7EI48
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P10398 587
xref: PTHR44329:SF55
organism: Homo sapiens

ADP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q5ZJ46 730
type: UnificationXref
id: Q5ZJ46
db: uniprot

uniprot F1Q2Y3 625
type: UnificationXref
id: F1Q2Y3
db: uniprot

Serine/threonine-protein kinase RIM11/MSD1
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot P38615 360
organism: Saccharomyces cerevisiae

uniprot F1N795 327
type: UnificationXref
id: F1N795
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF43
xref: uniprot A0A3Q1MLN6 30
organism: Bos taurus

uniprot P15063 884
type: UnificationXref
id: P15063
db: uniprot

TRANSPORT_LEFT__p90RSK-RIGHT__p90RSK-_r66
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 1159
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 1160
left: p90RSK
interaction type: TRANSPORT
right: p90RSK

uniprot Q6P1T1 888
type: UnificationXref
id: Q6P1T1
db: uniprot

Ribosomal protein S6 kinase alpha-3
type: ProteinReference
xref: uniprot P18654 74
xref: PTHR24351:SF58
organism: Mus musculus

Ribosomal protein S6 kinase alpha-1
type: ProteinReference
xref: PTHR24351:SF43
xref: uniprot P18653 73
organism: Mus musculus

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot O88763 795
xref: PTHR10048:SF7
organism: Rattus norvegicus

Ribosomal protein S6 kinase 2 alpha
type: ProteinReference
xref: PTHR24351:SF43
xref: uniprot P18652 72
organism: Gallus gallus

uniprot A0A3S5ZPX3 598
type: UnificationXref
id: A0A3S5ZPX3
db: uniprot

Rho GTPase-activating protein 15
type: ProteinReference
xref: uniprot Q5ZMM3 1038
xref: PTHR23176:SF108
organism: Gallus gallus

Complex (Grb2/Shc/ SOS)
type: Complex
component stoichiometry: Grb2 s9 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Shc s13 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS s17 sa7 STOICHIOMETRY ID COMPLEX
component: Shc
component: SOS
component: Grb2
feature: COMPLEX BINDING FEATURE s50 a58 1099
feature: COMPLEX BINDING FEATURE s50 a58 1097
feature: COMPLEX BINDING FEATURE s50 a58 1095
cellular location: cytoplasm

ncbitaxon 9031 20
type: UnificationXref
id: 9031
db: ncbitaxon

Signal transducer and activator of transcription 2
type: ProteinReference
xref: uniprot P52630 932
organism: Homo sapiens

uniprot F6QZT8 679
type: UnificationXref
id: F6QZT8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MFK1 299
xref: PTHR24356:SF322
organism: Bos taurus

Serine/threonine-protein kinase N2
type: ProteinReference
xref: PTHR24356:SF322
xref: uniprot O08874 304
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LWV5 958
xref: PTHR12552:SF4
organism: Bos taurus

uniprot F6QE96 315
type: UnificationXref
id: F6QE96
db: uniprot

uniprot A0A2I3T332 343
type: UnificationXref
id: A0A2I3T332
db: uniprot

GSK3
type: Protein
entity reference: GSK3
feature: GSK3 s100 a144 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P32254 446
type: UnificationXref
id: P32254
db: uniprot

uniprot Q5TQX0 565
type: UnificationXref
id: Q5TQX0
db: uniprot

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot P18266 359
organism: Rattus norvegicus

E74 like ETS transcription factor 2
type: ProteinReference
xref: uniprot E2QU99 669
xref: PTHR11849:SF10
organism: Canis lupus familiaris

Glycogen synthase kinase-3 alpha
type: ProteinReference
xref: PTHR24057:SF14
xref: uniprot P18265 358
organism: Rattus norvegicus

SLIT-ROBO Rho GTPase-activating protein 2
type: ProteinReference
xref: uniprot Q91Z67 1054
organism: Mus musculus

ARHGAP4 isoform 7
type: ProteinReference
xref: uniprot A0A2I3TGI1 957
organism: Pan troglodytes

PDGF s128 a169 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PDGF
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot K7CDC2 316
xref: PTHR24356:SF176
organism: Pan troglodytes

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot Q6DV79 940
organism: Gallus gallus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Jak-_ATP-RIGHT__Jak-_ADP-_r18
controller: Complex (PDGF receptor A/PDGF receptor B)

Cell division control protein 25
type: ProteinReference
xref: uniprot Q7RYH5 537
organism: Neurospora crassa

uniprot Q9WVS8 187
type: UnificationXref
id: Q9WVS8
db: uniprot

Protein C-ets-1
type: ProteinReference
xref: uniprot P14921 704
xref: PTHR11849:SF209
organism: Homo sapiens

uniprot Q8UUX0 320
type: UnificationXref
id: Q8UUX0
db: uniprot

SLIT-ROBO Rho GTPase-activating protein 1
type: ProteinReference
xref: uniprot Q91Z69 1055
organism: Mus musculus

uniprot Q5RJP7 500
type: UnificationXref
id: Q5RJP7
db: uniprot

uniprot F7H3I5 1002
type: UnificationXref
id: F7H3I5
db: uniprot

uniprot Q9UKW4 843
type: UnificationXref
id: Q9UKW4
db: uniprot

Jak s111 a48 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.04
comment: MODIFICATION_RESIDUE_NAME=

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P52631 933
organism: Rattus norvegicus

Signal transducer and activator of transcription 5B
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot P52632 934
organism: Rattus norvegicus

Signal transducer and transcription activator 6
type: ProteinReference
xref: PTHR11801:SF48
xref: uniprot P52633 935
organism: Mus musculus

uniprot A0A1D5QTL2 896
type: UnificationXref
id: A0A1D5QTL2
db: uniprot

uniprot P31240 854
type: UnificationXref
id: P31240
db: uniprot

RAS-like, estrogen-regulated, growth-inhibitor
type: ProteinReference
xref: uniprot F1M2G3 409
organism: Rattus norvegicus

uniprot H2QVT0 495
type: UnificationXref
id: H2QVT0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VH29 994
organism: Ornithorhynchus anatinus

PTHR24057:SF14
type: RelationshipXref
id: PTHR24057:SF14
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q3ACS4 754
xref: PTHR10155:SF3
organism: Gallus gallus

uniprot H2R1I1 1014
type: UnificationXref
id: H2R1I1
db: uniprot

uniprot P27870 836
type: UnificationXref
id: P27870
db: uniprot

uniprot Q54TK8 534
type: UnificationXref
id: Q54TK8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11849:SF15
xref: uniprot F7EKJ9 688
organism: Monodelphis domestica

uniprot E1BCH7 286
type: UnificationXref
id: E1BCH7
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot F7BYN4 914
organism: Monodelphis domestica

ncbitaxon 10090 16
type: UnificationXref
id: 10090
db: ncbitaxon

Ras guanine nucleotide exchange factor B
type: ProteinReference
xref: uniprot Q8IS21 539
organism: Dictyostelium discoideum

PARTICIPANT STOICHIOMETRY r17 1110
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r17 1111
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

Raf
type: Protein
entity reference: Raf
feature: Raf s22 a65 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r17 1112
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Cdc42 GTPase-activating protein
type: ProteinReference
xref: PTHR45808:SF6
xref: uniprot A4GT58 961
organism: Canis lupus familiaris

uniprot Q8NEB9 818
type: UnificationXref
id: Q8NEB9
db: uniprot

Rho GTPase-activating protein 68F
type: ProteinReference
xref: uniprot Q9VTU3 1062
organism: Drosophila melanogaster

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7CQS0 61
xref: PTHR24351:SF171
organism: Macaca mulatta

uniprot F6VTR8 771
type: UnificationXref
id: F6VTR8
db: uniprot

E4tf1-60 transcription factor
type: ProteinReference
xref: uniprot Q9I9E8 738
xref: PTHR11849:SF195
organism: Danio rerio

uniprot E1BEL4 472
type: UnificationXref
id: E1BEL4
db: uniprot

Ras guanine nucleotide exchange factor A
type: ProteinReference
xref: uniprot Q54PQ4 533
organism: Dictyostelium discoideum

ELK
type: Protein
entity reference: ELK
feature: ELK s88 a138 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F1N7C3 519
xref: PTHR23113:SF168
organism: Bos taurus

uniprot F1Q118 521
type: UnificationXref
id: F1Q118
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63085 157
xref: PTHR24055:SF203
organism: Mus musculus

uniprot Q9EQH1 269
type: UnificationXref
id: Q9EQH1
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63086 158
xref: PTHR24055:SF203
organism: Rattus norvegicus

uniprot V5ILY7 389
type: UnificationXref
id: V5ILY7
db: uniprot

PKC s117 a113 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q59XU5 459
type: UnificationXref
id: Q59XU5
db: uniprot

PARTICIPANT STOICHIOMETRY r17 1109
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot F6QM53 766
type: UnificationXref
id: F6QM53
db: uniprot

uniprot A0A2I3TN41 624
type: UnificationXref
id: A0A2I3TN41
db: uniprot

uniprot A0A2I3T7A8 749
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

uniprot G3V926 223
type: UnificationXref
id: G3V926
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot P53779 156
organism: Homo sapiens

uniprot P42339 805
type: UnificationXref
id: P42339
db: uniprot

Raf
type: Protein
entity reference: Raf
feature: Raf s22 a66 rs1
feature: ACTIVE 18
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q4KM68 260
type: UnificationXref
id: Q4KM68
db: uniprot

uniprot A0A2I3SSC7 541
type: UnificationXref
id: A0A2I3SSC7
db: uniprot

uniprot Q552M5 535
type: UnificationXref
id: Q552M5
db: uniprot

uniprot P85298 1027
type: UnificationXref
id: P85298
db: uniprot

uniprot F1QNG4 411
type: UnificationXref
id: F1QNG4
db: uniprot

uniprot A0A0G2JVF0 949
type: UnificationXref
id: A0A0G2JVF0
db: uniprot

Evidence 574
type: Evidence
evidence code: ISS
comment: SPACC Q99N57

Uncharacterized protein
type: ProteinReference
xref: PTHR11849:SF10
xref: uniprot F1N599 675
organism: Bos taurus

uniprot F7FHD1 139
type: UnificationXref
id: F7FHD1
db: uniprot

Evidence 573
type: Evidence
evidence code: ISS
comment: SPACC P11345

Evidence 572
type: Evidence
evidence code: ISS
comment: SPACC P05625

Evidence 571
type: Evidence
evidence code: ISS
comment: SPACC P04049

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot F1MSX4 121
organism: Bos taurus

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF109
type: RelationshipXref
id: PTHR10048:SF109
db: PANTHER Family
relationship type: By Homology

Nck
type: ProteinReference
xref: P01147
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.Nck
comment: ENTITY_REFERENCE_NOTES= Long Name: Nck Synonym: GRB4,MELANOMA NCK PROTEIN,NCK ADAPTOR PROTEIN Accession: P01147
member entity reference: Cytoplasmic protein
member entity reference: Cytoplasmic protein NCK2
member entity reference: Cytoplasmic protein NCK1

Uncharacterized protein
type: ProteinReference
evidence: Evidence 573
evidence: Evidence 574
evidence: Evidence 571
evidence: Evidence 572
xref: PTHR44329:SF22
xref: uniprot F7BRK5 582
organism: Monodelphis domestica

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q02750 609
organism: Homo sapiens

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF19
xref: uniprot A0A2R8Q947 901
organism: Danio rerio

uniprot Q10452 367
type: UnificationXref
id: Q10452
db: uniprot

Son of sevenless homolog 1
type: ProteinReference
xref: uniprot Q62245 536
xref: PTHR23113:SF168
organism: Mus musculus

uniprot P28028 592
type: UnificationXref
id: P28028
db: uniprot

ARHGAP10 isoform 3
type: ProteinReference
xref: uniprot K7C248 1018
xref: PTHR12552:SF5
organism: Pan troglodytes

V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot A0A2R8Q8S1 393
organism: Danio rerio

uniprot Q99607 737
type: UnificationXref
id: Q99607
db: uniprot

uniprot F7BQ11 913
type: UnificationXref
id: F7BQ11
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LWJ8 107
xref: PTHR24055:SF222
organism: Bos taurus

PTHR24070:SF17
type: RelationshipXref
id: PTHR24070:SF17
db: PANTHER Family
relationship type: By Homology

uniprot P09416 883
type: UnificationXref
id: P09416
db: uniprot

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot Q9QY78 234
organism: Rattus norvegicus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A2I3TNY5 898
xref: PTHR11801:SF18
organism: Pan troglodytes

uniprot H2PXY8 786
type: UnificationXref
id: H2PXY8
db: uniprot

Growth factor receptor-bound protein 2
type: ProteinReference
evidence: Evidence 266
xref: uniprot Q6PC73 265
xref: PTHR46037:SF4
organism: Danio rerio

uniprot F6V2H6 128
type: UnificationXref
id: F6V2H6
db: uniprot

PLCgamma s18 a109 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Upstream stimulatory factor 2
type: ProteinReference
xref: uniprot Q15853 212
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r37 1148
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

uniprot Q12701 631
type: UnificationXref
id: Q12701
db: uniprot

PARTICIPANT STOICHIOMETRY r37 1147
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

uniprot H2QNH9 331
type: UnificationXref
id: H2QNH9
db: uniprot

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 402

uniprot G3V9W2 482
type: UnificationXref
id: G3V9W2
db: uniprot

uniprot Q6AYC5 1041
type: UnificationXref
id: Q6AYC5
db: uniprot

ELK s31 a122 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ARHGAP6 isoform 1
type: ProteinReference
xref: uniprot H2QYA3 1013
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot W4Y0P1 390
xref: PTHR24057:SF0
organism: Strongylocentrotus purpuratus

Ras guanine nucleotide exchange factor E
type: ProteinReference
xref: uniprot Q8IS18 538
organism: Dictyostelium discoideum

GA binding protein transcription factor, alpha subunit 60kDa
type: ProteinReference
xref: uniprot Q0VC98 721
xref: PTHR11849:SF195
organism: Bos taurus

uniprot P01106 881
type: UnificationXref
id: P01106
db: uniprot

uniprot Q93372 375
type: UnificationXref
id: Q93372
db: uniprot

ERK
type: Protein
entity reference: ERK
feature: ERK s24 a71 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q6DV79 940
type: UnificationXref
id: Q6DV79
db: uniprot

GTPase HRas isoform 1
type: ProteinReference
xref: uniprot F7F5K9 418
xref: PTHR24070:SF385
organism: Macaca mulatta

Rho GTPase-activating protein 10
type: ProteinReference
xref: uniprot Q6Y5D8 1044
xref: PTHR12552:SF5
organism: Mus musculus

Vav guanine nucleotide exchange factor 3
type: ProteinReference
xref: PTHR45818:SF1
xref: uniprot F1LWB1 829
organism: Rattus norvegicus

uniprot P52631 933
type: UnificationXref
id: P52631
db: uniprot

uniprot A0A2I3TGI1 957
type: UnificationXref
id: A0A2I3TGI1
db: uniprot

ncbitaxon 7955 102
type: UnificationXref
id: 7955
db: ncbitaxon

Rho GTPase-activating protein 4
type: ProteinReference
xref: uniprot P98171 1029
organism: Homo sapiens

ERK
type: ProteinReference
xref: P01143
standard name: Extracellular signal-regulated kinase family
comment: ENTITY_REFERENCE_NOTES= Long Name: Extracellular signal-regulated kinase family Synonym: ERK,Maturation- or mitogen-activated protein (MAP) kinase family Accession: P01143
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.ERK
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 18
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase kinase kinase 2
member entity reference: Mitogen-activated protein kinase 7
member entity reference: Mitogen-activated protein kinase 15
member entity reference: Mitogen-activated protein kinase 10
member entity reference: Extracellular signal-regulated kinase 1
member entity reference: Mitogen-activated protein kinase 6
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Extracellular signal-regulated kinase 2
member entity reference: Mitogen-activated protein kinase kinase kinase 4
member entity reference: Mitogen-activated protein kinase 20
member entity reference: MAP3K2 isoform 1
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Mitogen-activated protein kinase 2
member entity reference: Mitogen-activated protein kinase 19
member entity reference: MAPK6 isoform 1
member entity reference: Mitogen-activated protein kinase 16

Rho GTPase-activating protein 5
type: ProteinReference
xref: uniprot A0A0G2K7N9 951
organism: Rattus norvegicus

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot F1PW15 878
xref: PTHR45851:SF1
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTP-_Ras-RIGHT__GDP-_Ras-_r20
controller: Complex (Grb2/Shc/ SOS)

Rho GTPase-activating protein 7
type: ProteinReference
xref: uniprot Q63744 1040
organism: Rattus norvegicus

uniprot Q18955 640
type: UnificationXref
id: Q18955
db: uniprot

uniprot Q07890 532
type: UnificationXref
id: Q07890
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_MEK-RIGHT__MEK-_ADP-_r22
controller: Raf

Rho GTPase-activating protein 5
type: ProteinReference
xref: uniprot Q13017 1032
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F1PS03 863
organism: Canis lupus familiaris

Glycogen synthase kinase
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot Q9NL43 380
organism: Ciona intestinalis

uniprot G2HHN0 279
type: UnificationXref
id: G2HHN0
db: uniprot

uniprot Q07960 1030
type: UnificationXref
id: Q07960
db: uniprot

STAT s11 a53 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR11801:SF48
type: RelationshipXref
id: PTHR11801:SF48
db: PANTHER Family
relationship type: By Homology

uniprot Q9C5C0 181
type: UnificationXref
id: Q9C5C0
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF43
xref: uniprot F6S876 48
organism: Xenopus tropicalis

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot F1N0D6 474
organism: Bos taurus

Cytoplasmic protein NCK1
type: ProteinReference
xref: PTHR19969:SF16
xref: uniprot P16333 283
organism: Homo sapiens

uniprot F6RQ55 493
type: UnificationXref
id: F6RQ55
db: uniprot

uniprot A0A0G2K344 744
type: UnificationXref
id: A0A0G2K344
db: uniprot

uniprot F0ZI47 405
type: UnificationXref
id: F0ZI47
db: uniprot

uniprot P49137 509
type: UnificationXref
id: P49137
db: uniprot

Rho
type: ProteinReference
xref: P01174
standard name: GTPase-activating protein Rho
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.Rho
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: GTPase-activating protein Rho Synonym: Rho-GTPase-activating protein,RhoGAP Accession: P01174
member entity reference: SLIT-ROBO Rho GTPase-activating protein 2
member entity reference: Rho GTPase-activating protein 4
member entity reference: Rho GTPase-activating protein 6
member entity reference: Rho GTPase-activating protein 12
member entity reference: Oligophrenin-1
member entity reference: Uncharacterized protein
member entity reference: ARHGAP4 isoform 7
member entity reference: SLIT-ROBO Rho GTPase-activating protein 1b
member entity reference: Slit-Robo GAP homolog
member entity reference: GTPase regulator associated with FAK, isoform G
member entity reference: Rho GTPase-activating protein 9
member entity reference: Rho GTPase activating protein at 16F, isoform E
member entity reference: Rho GTPase-activating protein 7
member entity reference: StAR-related lipid transfer domain-containing 13
member entity reference: StAR-related lipid transfer protein 8
member entity reference: Rho GTPase-activating protein 10
member entity reference: Rho GTPase Activating protein
member entity reference: ARHGAP26 isoform 1
member entity reference: Rho GTPase activating protein 15
member entity reference: Rho GTPase-activating protein 15
member entity reference: Rho GTPase-activating protein 1
member entity reference: Rho GTPase-activating protein 8
member entity reference: SLIT-ROBO Rho GTPase-activating protein 3
member entity reference: Rho GTPase-activating protein 42
member entity reference: Protein CBR-SRGP-1
member entity reference: SLIT-ROBO Rho GTPase-activating protein 1
member entity reference: SLIT-ROBO Rho GTPase-activating protein 2 isoform a
member entity reference: SLIT-ROBO Rho GTPase activating protein 3
member entity reference: WW domain-containing protein tag-325
member entity reference: Rho GTPase-activating protein 26
member entity reference: Rho GTPase activating protein 4, isoform CRA_a
member entity reference: Rho GTPase-activating protein 5
member entity reference: Rho GTPase activating protein 1
member entity reference: SLIT-ROBO Rho GTPase activating protein 2
member entity reference: SLIT-ROBO Rho GTPase activating protein 1
member entity reference: ARHGAP10 isoform 3
member entity reference: STARD13 isoform 4
member entity reference: Rho GTPase activating protein 5
member entity reference: StAR-related lipid transfer domain-containing 8
member entity reference: Rho GTPase-activating protein 27

uniprot Q4QGB0 511
type: UnificationXref
id: Q4QGB0
db: uniprot

AGAP002729-PA
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot Q7QCN5 338
organism: Anopheles gambiae

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot A0A0G2K344 744
xref: PTHR10048:SF107
organism: Rattus norvegicus

Fli-1 proto-oncogene, ETS transcription factor
type: ProteinReference
xref: PTHR11849:SF161
xref: uniprot Q4Z8P1 727
organism: Rattus norvegicus

PI3K
type: Protein
entity reference: PI3K
feature: ACTIVE 18
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r35
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 1153
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 1154
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 1155
left: PIP2
interaction type: DISSOCIATION
right: IP3
right: DAG

Ninein-like protein
type: ProteinReference
xref: uniprot Q9Y2I6 386
organism: Homo sapiens

uniprot Q58D94 292
type: UnificationXref
id: Q58D94
db: uniprot

Mitogen-activated protein kinase 18
type: ProteinReference
xref: uniprot Q9C5C0 181
xref: PTHR24055:SF420
organism: Arabidopsis thaliana

SLIT-ROBO Rho GTPase-activating protein 3
type: ProteinReference
xref: uniprot O43295 1022
organism: Homo sapiens

uniprot E2RHV6 274
type: UnificationXref
id: E2RHV6
db: uniprot

Uncharacterized protein rasB
type: ProteinReference
xref: PTHR24070:SF206
xref: uniprot F0ZI47 405
organism: Dictyostelium purpureum

RAS like estrogen regulated growth inhibitor
type: ProteinReference
xref: uniprot H2Q5J1 423
organism: Pan troglodytes

uniprot P20936 334
type: UnificationXref
id: P20936
db: uniprot

uniprot Q64143 814
type: UnificationXref
id: Q64143
db: uniprot

Signal transducer and activator of transcription 5A
type: ProteinReference
xref: PTHR11801:SF47
xref: uniprot Q95115 943
organism: Bos taurus

uniprot B8JIQ1 347
type: UnificationXref
id: B8JIQ1
db: uniprot

uniprot Q9UKW6 741
type: UnificationXref
id: Q9UKW6
db: uniprot

uniprot F7AKA6 133
type: UnificationXref
id: F7AKA6
db: uniprot

Uncharacterized protein rasG
type: ProteinReference
xref: uniprot F0ZWE6 407
xref: PTHR24070:SF17
organism: Dictyostelium purpureum

uniprot F6VDT1 993
type: UnificationXref
id: F6VDT1
db: uniprot

PTHR12659:SF3
type: RelationshipXref
id: PTHR12659:SF3
db: PANTHER Family
relationship type: By Homology

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot Q14573 563
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F1Q3M8 765
organism: Canis lupus familiaris

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot Q14571 562
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__c_Jun-_ATP-RIGHT__c_Jun-_ADP-_r58
controller: ERK

uniprot H9FU38 556
type: UnificationXref
id: H9FU38
db: uniprot

PTHR12659:SF4
type: RelationshipXref
id: PTHR12659:SF4
db: PANTHER Family
relationship type: By Homology

uniprot Q01543 718
type: UnificationXref
id: Q01543
db: uniprot

uniprot H2QLQ2 849
type: UnificationXref
id: H2QLQ2
db: uniprot

uniprot F6VTW2 995
type: UnificationXref
id: F6VTW2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5ZIF0 614
xref: PTHR48013:SF5
organism: Gallus gallus

p90RSK
type: Protein
entity reference: p90RSK
feature: p90RSK s94 a121 rs1
feature: ACTIVE 18
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot H9FVU5 789
organism: Macaca mulatta

PTHR23113:SF150
type: RelationshipXref
id: PTHR23113:SF150
db: PANTHER Family
relationship type: By Homology

uniprot O93468 429
type: UnificationXref
id: O93468
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot P36507 607
xref: PTHR48013:SF8
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36506 606
organism: Rattus norvegicus

uniprot Q00422 717
type: UnificationXref
id: Q00422
db: uniprot

uniprot H2QLB4 144
type: UnificationXref
id: H2QLB4
db: uniprot

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot P20444 306
type: UnificationXref
id: P20444
db: uniprot

uniprot P51136 365
type: UnificationXref
id: P51136
db: uniprot

Ehf protein
type: ProteinReference
xref: uniprot B2RYD8 660
xref: PTHR11849:SF171
organism: Rattus norvegicus

Mitogen-activated protein kinase 20
type: ProteinReference
xref: uniprot Q9SJG9 186
organism: Arabidopsis thaliana

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q4Y8 953
xref: PTHR23176:SF103
organism: Macaca mulatta

PTHR48013:SF8
type: RelationshipXref
id: PTHR48013:SF8
db: PANTHER Family
relationship type: By Homology

uniprot Q6PE55 501
type: UnificationXref
id: Q6PE55
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot F7BTW0 60
xref: PTHR24351:SF48
organism: Monodelphis domestica

uniprot Q9Y2I6 386
type: UnificationXref
id: Q9Y2I6
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: uniprot F6Y841 774
xref: PTHR10048:SF33
organism: Canis lupus familiaris

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot D3ZFJ0 755
organism: Rattus norvegicus

uniprot H2Q486 65
type: UnificationXref
id: H2Q486
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 114

PTHR48013:SF5
type: RelationshipXref
id: PTHR48013:SF5
db: PANTHER Family
relationship type: By Homology

RCG60727
type: ProteinReference
xref: uniprot B2RYE0 661
xref: PTHR11849:SF182
organism: Rattus norvegicus

uniprot Q8CDB0 295
type: UnificationXref
id: Q8CDB0
db: uniprot

uniprot F7ACT4 351
type: UnificationXref
id: F7ACT4
db: uniprot

ETS domain-containing protein Elk-4 isoform a
type: ProteinReference
xref: uniprot F6XTS0 10
xref: PTHR11849:SF21
organism: Macaca mulatta

Transcriptional regulator Erg
type: ProteinReference
xref: uniprot Q90837 735
xref: PTHR11849:SF216
organism: Gallus gallus

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot P62993 254
xref: PTHR46037:SF4
organism: Homo sapiens

PI3K
type: Protein
entity reference: PI3K
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot P62994 255
xref: PTHR46037:SF4
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TD14 769
xref: PTHR10155:SF3
organism: Monodelphis domestica

uniprot F6SW23 767
type: UnificationXref
id: F6SW23
db: uniprot

STAT s11 a53 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.459809653788574
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot P29355 253
type: UnificationXref
id: P29355
db: uniprot

uniprot P97393 1028
type: UnificationXref
id: P97393
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RHV4 988
organism: Monodelphis domestica

Signal transducer and activator of transcription 1
type: ProteinReference
xref: uniprot Q9NAD6 944
organism: Caenorhabditis elegans

uniprot P11308 702
type: UnificationXref
id: P11308
db: uniprot

uniprot F6Z0J4 775
type: UnificationXref
id: F6Z0J4
db: uniprot

uniprot F6ZKB3 132
type: UnificationXref
id: F6ZKB3
db: uniprot

uniprot B3DM35 662
type: UnificationXref
id: B3DM35
db: uniprot

Uncharacterized protein rasS
type: ProteinReference
xref: uniprot F0ZVH9 406
xref: PTHR24070:SF380
organism: Dictyostelium purpureum

Tyrosine-protein kinase JAK2
type: ProteinReference
xref: uniprot Q62689 491
xref: PTHR45807:SF1
organism: Rattus norvegicus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6SW23 767
organism: Gallus gallus

uniprot Q62245 536
type: UnificationXref
id: Q62245
db: uniprot

uniprot F6W7C8 773
type: UnificationXref
id: F6W7C8
db: uniprot

uniprot A0A2I3RZ31 105
type: UnificationXref
id: A0A2I3RZ31
db: uniprot

PTHR45816:SF3
type: RelationshipXref
id: PTHR45816:SF3
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3TF56 652
type: UnificationXref
id: A0A2I3TF56
db: uniprot

Ras-related protein Rab-11B
type: ProteinReference
xref: uniprot P46638 447
organism: Mus musculus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F7BQ11 913
xref: PTHR11801:SF39
organism: Gallus gallus

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot F6ZM84 776
xref: PTHR10048:SF7
organism: Xenopus tropicalis

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot A0A3Q1MMD9 860
organism: Bos taurus

uniprot H2Q9G3 142
type: UnificationXref
id: H2Q9G3
db: uniprot

uniprot W4Y0P1 390
type: UnificationXref
id: W4Y0P1
db: uniprot

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot Q9Y6R4 189
organism: Homo sapiens

uniprot Q03306 628
type: UnificationXref
id: Q03306
db: uniprot

uniprot Q7PV64 267
type: UnificationXref
id: Q7PV64
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11849:SF15
xref: uniprot F6PLC7 677
organism: Macaca mulatta

uniprot B7ZVG9 968
type: UnificationXref
id: B7ZVG9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_r51
controller: MAPKAPK2

uniprot D3ZFJ0 755
type: UnificationXref
id: D3ZFJ0
db: uniprot

SHC-transforming protein 1
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot Q5M824 1076
organism: Rattus norvegicus

RAB11B, member RAS oncogene family, gene 2
type: ProteinReference
xref: uniprot F6Z499 413
organism: Xenopus tropicalis

uniprot Q01986 608
type: UnificationXref
id: Q01986
db: uniprot

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q9XF67 636
organism: Arabidopsis thaliana

uniprot D4A7F2 877
type: UnificationXref
id: D4A7F2
db: uniprot

PLCgamma s16 a107 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot H2QLZ4 553
organism: Pan troglodytes

IP3
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR14166:SF15
type: RelationshipXref
id: PTHR14166:SF15
db: PANTHER Family
relationship type: By Homology

GSK3
type: ProteinReference
xref: P01153
standard name: Glycogen synthase kinase 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.GSK3
comment: ENTITY_REFERENCE_NOTES= Long Name: GSK3 Synonym: GLYCOGEN SYNTHASE KINASE 3 Accession: P01153
member entity reference: Glycogen synthase kinase-3
member entity reference: Glycogen synthase kinase-3 beta
member entity reference: Glycogen synthase kinase-3 alpha
member entity reference: Shaggy-related protein kinase theta
member entity reference: Pk34A
member entity reference: Os10g0521700 protein
member entity reference: Protein CBG07560
member entity reference: Shaggy-related protein kinase alpha
member entity reference: Ninein like
member entity reference: Uncharacterized protein
member entity reference: Glycogen synthase kinase 3 beta
member entity reference: Glycogen synthase kinase 3
member entity reference: Putative glycogen synthase kinase-3 homolog
member entity reference: Os01g0252100 protein
member entity reference: Protein kinase gsk3
member entity reference: Shaggy-related protein kinase beta
member entity reference: Ninein
member entity reference: Protein kinase gsk31
member entity reference: Os01g0296100 protein
member entity reference: Si:dkeyp-80c12.7
member entity reference: Glycogen synthase kinase-3 beta isoform 1
member entity reference: Shaggy-related protein kinase epsilon
member entity reference: Shaggy-related protein kinase gamma
member entity reference: Serine/threonine-protein kinase RIM11/MSD1
member entity reference: Shaggy-related protein kinase eta
member entity reference: Shaggy-related protein kinase delta
member entity reference: Glycogen synthase kinase
member entity reference: Shaggy-related protein kinase iota
member entity reference: Glycogen synthase kinase 3 alpha
member entity reference: Ninein-like protein

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q7ZVK8 176
xref: PTHR24055:SF393
organism: Danio rerio

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 308

uniprot B4F6M4 663
type: UnificationXref
id: B4F6M4
db: uniprot

uniprot F6R1P6 909
type: UnificationXref
id: F6R1P6
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F6URW3 523
xref: PTHR23113:SF150
organism: Ornithorhynchus anatinus

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot H2QSU0 554
organism: Pan troglodytes

uniprot P42336 802
type: UnificationXref
id: P42336
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 95

Ras GTPase-activating protein 4
type: ProteinReference
xref: PTHR10194:SF4
xref: uniprot O43374 333
organism: Homo sapiens

ETS domain-containing transcription factor ERF
type: ProteinReference
xref: PTHR11849:SF31
xref: uniprot P70459 714
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_p90RSK-RIGHT__p90RSK-_ADP-_r27
controller: ERK

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
type: ProteinReference
xref: uniprot Q22070 871
organism: Caenorhabditis elegans

uniprot Q63788 812
type: UnificationXref
id: Q63788
db: uniprot

SLIT-ROBO Rho GTPase activating protein 3
type: ProteinReference
xref: uniprot F6QGZ1 987
organism: Monodelphis domestica

uniprot P36583 309
type: UnificationXref
id: P36583
db: uniprot

PDGF receptor B s6 sa4 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.8120576328758515
comment: MODIFICATION_RESIDUE_NAME=

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot Q63269 566
organism: Rattus norvegicus

uniprot O15111 226
type: UnificationXref
id: O15111
db: uniprot

PLCgamma
type: Protein
entity reference: PLCgamma
feature: PLCgamma s16 a107 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5QL06 22
type: UnificationXref
id: A0A1D5QL06
db: uniprot

uniprot P48423 335
type: UnificationXref
id: P48423
db: uniprot

uniprot Q63932 615
type: UnificationXref
id: Q63932
db: uniprot

SAM pointed domain containing ETS transcription factor
type: ProteinReference
xref: uniprot H2QSV0 693
xref: PTHR11849:SF182
organism: Pan troglodytes

Ras GTPase-activating protein 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot P50904 336
organism: Rattus norvegicus

uniprot F7HS52 247
type: UnificationXref
id: F7HS52
db: uniprot

SLIT-ROBO Rho GTPase-activating protein 2
type: ProteinReference
xref: PTHR14166:SF6
xref: uniprot F7EEN8 999
organism: Xenopus tropicalis

uniprot Q9W4S7 893
type: UnificationXref
id: Q9W4S7
db: uniprot

uniprot Q9BUB5 296
type: UnificationXref
id: Q9BUB5
db: uniprot

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: uniprot Q66JF3 294
organism: Xenopus tropicalis

uniprot P19419 12
type: UnificationXref
id: P19419
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF213
xref: uniprot F6UWI0 55
organism: Canis lupus familiaris

uniprot Q8BTI9 817
type: UnificationXref
id: Q8BTI9
db: uniprot

uniprot F6TPX7 51
type: UnificationXref
id: F6TPX7
db: uniprot

uniprot P16234 514
type: UnificationXref
id: P16234
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: Ets

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5PXC6 103
organism: Gallus gallus

uniprot E2RED4 976
type: UnificationXref
id: E2RED4
db: uniprot

uniprot Q8K031 1053
type: UnificationXref
id: Q8K031
db: uniprot

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 357

uniprot Q91Z69 1055
type: UnificationXref
id: Q91Z69
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot E2RQM0 862
xref: PTHR10336:SF25
organism: Canis lupus familiaris

ARHGAP5 isoform 3
type: ProteinReference
xref: uniprot H2R9D6 1016
organism: Pan troglodytes

Ikk
type: Protein
entity reference: Ikk
feature: Ikk s57 a100 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QAB6 321
xref: PTHR10194:SF21
organism: Macaca mulatta

uniprot P70459 714
type: UnificationXref
id: P70459
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot A0A3Q2TVV5 345
organism: Gallus gallus

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot F7ACT4 351
organism: Xenopus tropicalis

uniprot G5EBK8 421
type: UnificationXref
id: G5EBK8
db: uniprot

uniprot Q02384 530
type: UnificationXref
id: Q02384
db: uniprot

uniprot A0A1D5QZX3 23
type: UnificationXref
id: A0A1D5QZX3
db: uniprot

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: uniprot Q8BSK8 88
xref: PTHR24351:SF48
organism: Mus musculus

uniprot E2R9L4 118
type: UnificationXref
id: E2R9L4
db: uniprot

uniprot A0A3Q1LNQ6 27
type: UnificationXref
id: A0A3Q1LNQ6
db: uniprot

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q66JE6 616
organism: Xenopus tropicalis

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q6P023 175
xref: PTHR24055:SF203
organism: Danio rerio

uniprot O77344 356
type: UnificationXref
id: O77344
db: uniprot

PTHR45851:SF3
type: RelationshipXref
id: PTHR45851:SF3
db: PANTHER Family
relationship type: By Homology

MAP kinase interacting serine/threonine kinase 2
type: ProteinReference
xref: uniprot E1BCH7 286
xref: PTHR24349:SF254
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR13715:SF53
xref: uniprot F6ZCW7 551
organism: Monodelphis domestica

uniprot Q7Q334 1078
type: UnificationXref
id: Q7Q334
db: uniprot

SHC-transforming protein 1
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot P29353 1072
organism: Homo sapiens

Sex muscle abnormal protein 5
type: ProteinReference
xref: PTHR46037:SF1
xref: uniprot P29355 253
organism: Caenorhabditis elegans

PTHR45851:SF6
type: RelationshipXref
id: PTHR45851:SF6
db: PANTHER Family
relationship type: By Homology

uniprot Q66JF3 294
type: UnificationXref
id: Q66JF3
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: c-Jun

ETS-related transcription factor Elf-5
type: ProteinReference
xref: PTHR11849:SF15
xref: uniprot Q58DT0 728
organism: Bos taurus

uniprot F6PQA3 678
type: UnificationXref
id: F6PQA3
db: uniprot

uniprot Q60992 839
type: UnificationXref
id: Q60992
db: uniprot

uniprot Q9I9E8 738
type: UnificationXref
id: Q9I9E8
db: uniprot

Rho GTPase-activating protein 7
type: ProteinReference
xref: uniprot F1MIZ6 980
organism: Bos taurus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A2I3TQ88 899
xref: PTHR11801:SF2
organism: Pan troglodytes

uniprot H2QGF9 353
type: UnificationXref
id: H2QGF9
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 49

PTHR45851:SF1
type: RelationshipXref
id: PTHR45851:SF1
db: PANTHER Family
relationship type: By Homology

uniprot H9Z692 696
type: UnificationXref
id: H9Z692
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot K7BI90 68
xref: PTHR24351:SF41
organism: Pan troglodytes

uniprot A1A4S6 959
type: UnificationXref
id: A1A4S6
db: uniprot

TRIGGER
type: RelationshipTypeVocabulary

uniprot D4A3T0 517
type: UnificationXref
id: D4A3T0
db: uniprot

Ninein
type: ProteinReference
xref: uniprot Q61043 371
organism: Mus musculus

uniprot H9FU32 583
type: UnificationXref
id: H9FU32
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2R0G7 145
xref: PTHR24055:SF222
organism: Pan troglodytes

STATE_TRANSITION_LEFT__c_fos-RIGHT__c_fos-_r50
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 1235
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 1234
left: c-fos
interaction type: STATE_TRANSITION
right: c-fos

uniprot Q04688 719
type: UnificationXref
id: Q04688
db: uniprot

ncbitaxon 36329 357
type: UnificationXref
id: 36329
db: ncbitaxon

uniprot P15064 441
type: UnificationXref
id: P15064
db: uniprot

uniprot A0A2I3RCF6 648
type: UnificationXref
id: A0A2I3RCF6
db: uniprot

PDGF receptor A s5 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PDGF receptor A
stoichiometric coefficient: 1.0

uniprot Q9Z1M4 98
type: UnificationXref
id: Q9Z1M4
db: uniprot

uniprot A0A2J8MGP0 751
type: UnificationXref
id: A0A2J8MGP0
db: uniprot

uniprot F7HKP4 848
type: UnificationXref
id: F7HKP4
db: uniprot

uniprot E2RLD1 761
type: UnificationXref
id: E2RLD1
db: uniprot

uniprot B2RQE8 967
type: UnificationXref
id: B2RQE8
db: uniprot

GO GO:0005783 3
type: UnificationXref
id: GO:0005783
db: GO

uniprot F7E823 136
type: UnificationXref
id: F7E823
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot F6VAQ8 770
xref: PTHR10048:SF7
organism: Ornithorhynchus anatinus

ncbitaxon 6669 402
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot P23458 486
type: UnificationXref
id: P23458
db: uniprot

MNK1 2 s83 a77 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Ribosomal protein S6 kinase C1
type: ProteinReference
xref: uniprot E2RR13 44
organism: Canis lupus familiaris

uniprot P53779 156
type: UnificationXref
id: P53779
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A2I3T7A8 749
organism: Pan troglodytes

StAR-related lipid transfer domain-containing 13
type: ProteinReference
xref: uniprot D3ZU63 970
organism: Rattus norvegicus

uniprot Q8BSK8 88
type: UnificationXref
id: Q8BSK8
db: uniprot

Glycogen synthase kinase 3
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot O77344 356
organism: Plasmodium falciparum

uniprot P29353 1072
type: UnificationXref
id: P29353
db: uniprot

uniprot E2RB82 902
type: UnificationXref
id: E2RB82
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot P49187 155
organism: Rattus norvegicus

Platelet-derived growth factor receptor-like protein
type: ProteinReference
xref: uniprot Q5RJP7 500
organism: Rattus norvegicus

uniprot Q9VK37 384
type: UnificationXref
id: Q9VK37
db: uniprot

SRF s99 a126 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F7GD33 278
type: UnificationXref
id: F7GD33
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RFQ9 236
organism: Macaca mulatta

Dual specificity mitogen-activated protein kinase kinase dSOR1
type: ProteinReference
xref: PTHR48013:SF19
xref: uniprot Q24324 613
organism: Drosophila melanogaster

Cytoplasmic protein
type: ProteinReference
xref: uniprot F7D094 277
xref: PTHR19969:SF12
organism: Macaca mulatta

uniprot H2QRP5 1012
type: UnificationXref
id: H2QRP5
db: uniprot

MAPKAPK2 s85 a85 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR10337:SF11
type: RelationshipXref
id: PTHR10337:SF11
db: PANTHER Family
relationship type: By Homology

Fos proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: uniprot E2QYK5 199
xref: PTHR23351:SF4
organism: Canis lupus familiaris

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot Q9LV37 185
xref: PTHR24055:SF491
organism: Arabidopsis thaliana

PKB s15 a102 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r35
controller: PLCgamma

uniprot Q8R367 465
type: UnificationXref
id: Q8R367
db: uniprot

uniprot P54676 810
type: UnificationXref
id: P54676
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot E1BN61 39
xref: PTHR24351:SF115
organism: Bos taurus

uniprot A6QLU3 241
type: UnificationXref
id: A6QLU3
db: uniprot

PDGF receptor B
type: ProteinReference
xref: P01156
standard name: Platelet-Derived Growth Factor B
comment: ENTITY_REFERENCE_NOTES= Long Name: PDGF receptor B Synonym: PDGFRB,PDGFR,PDGFR1 Accession: P01156
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.RECEPTOR.PDGF_br_receptor B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Platelet-derived growth factor receptor beta
member entity reference: Platelet derived growth factor receptor like
member entity reference: Platelet-derived growth factor receptor-like protein
member entity reference: Uncharacterized protein

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_MAPKAPK2-RIGHT__MAPKAPK2-_ADP-_r28
controller: ERK

SRF isoform 1
type: ProteinReference
xref: uniprot K7D2P2 206
xref: PTHR48019:SF40
organism: Pan troglodytes

uniprot F7G3I5 782
type: UnificationXref
id: F7G3I5
db: uniprot

PDGFB isoform 1
type: ProteinReference
xref: uniprot H2QLQ2 849
organism: Pan troglodytes

PTHR24057:SF0
type: RelationshipXref
id: PTHR24057:SF0
db: PANTHER Family
relationship type: By Homology

SHC adaptor protein 3
type: ProteinReference
xref: PTHR10337:SF4
xref: uniprot F1PPW0 1067
organism: Canis lupus familiaris

Ets2 repressor factor
type: ProteinReference
xref: PTHR11849:SF31
xref: uniprot D3ZJW0 665
organism: Rattus norvegicus

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot E2RMC0 545
organism: Canis lupus familiaris

GSK3 s100 a144 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR24057:SF5
type: RelationshipXref
id: PTHR24057:SF5
db: PANTHER Family
relationship type: By Homology

PTHR24057:SF8
type: RelationshipXref
id: PTHR24057:SF8
db: PANTHER Family
relationship type: By Homology

uniprot H2R481 1015
type: UnificationXref
id: H2R481
db: uniprot

PDGF receptor A s1 a1 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.547240302970063

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: PTHR45816:SF3
xref: uniprot A0A3Q1N7P8 542
organism: Bos taurus

Ets
type: ProteinReference
xref: P01167
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.Ets
comment: ENTITY_REFERENCE_NOTES= Long Name: Ets Synonym: Ets transcription factors Accession: P01167
member entity reference: ETS-related transcription factor Elf-4
member entity reference: GA binding protein transcription factor subunit alpha
member entity reference: ETS-like protein pointed
member entity reference: E74 like ETS transcription factor 1
member entity reference: ETS-related transcription factor Elf-5
member entity reference: ETS homologous factor
member entity reference: ETS proto-oncogene 1, transcription factor
member entity reference: Uncharacterized protein
member entity reference: V-ets avian erythroblastosis virus E26 oncogene homolog
member entity reference: Fli-1 proto-oncogene, ETS transcription factor a
member entity reference: E74 like ETS transcription factor 2
member entity reference: ETS translocation variant 2
member entity reference: ETS transcription factor ERG
member entity reference: Protein FEV
member entity reference: ETS-related transcription factor Elf-2 isoform 1
member entity reference: SAM pointed domain containing ets transcription factor
member entity reference: ETS domain-containing transcription factor ERF
member entity reference: Transcriptional regulator ERG
member entity reference: FEV, ETS transcription factor
member entity reference: LOC100170599 protein
member entity reference: Ets2 repressor factor
member entity reference: Friend leukemia integration 1 transcription factor
member entity reference: DNA-binding protein Ets97D
member entity reference: GA binding protein transcription factor, alpha subunit 60kDa
member entity reference: ERF isoform 1
member entity reference: Ehf protein
member entity reference: Ecdysone-induced protein 74EF isoform B
member entity reference: Protein C-ets-1
member entity reference: ERG isoform 10
member entity reference: GA-binding protein alpha chain
member entity reference: ETS-related transcription factor Elf-3
member entity reference: E74 like ETS transcription factor 5
member entity reference: GA repeat binding protein, alpha (Predicted)
member entity reference: ETS translocation variant 3
member entity reference: E74-like ETS transcription factor 1
member entity reference: ETS2 repressor factor
member entity reference: Transcriptional regulator Erg
member entity reference: ETS-related transcription factor Elf-2
member entity reference: E4tf1-60 transcription factor
member entity reference: Ets variant 2
member entity reference: ETS variant 3
member entity reference: E74-like ETS transcription factor 2
member entity reference: Fli-1 proto-oncogene, ETS transcription factor
member entity reference: SAM pointed domain-containing Ets transcription factor
member entity reference: DNA-binding protein D-ETS-6
member entity reference: Ets variant 3

PTHR48013:SF19
type: RelationshipXref
id: PTHR48013:SF19
db: PANTHER Family
relationship type: By Homology

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P31751 317
organism: Homo sapiens

Ets variant 3
type: ProteinReference
xref: PTHR11849:SF30
xref: uniprot G3V813 690
organism: Rattus norvegicus

Bos taurus
type: BioSource
xref: ncbitaxon 9913 28

PARTICIPANT STOICHIOMETRY r27 1200
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Protein B-Myc
type: ProteinReference
xref: PTHR45851:SF6
xref: uniprot Q6P8Z1 889
organism: Mus musculus

Rho GTPase-activating protein 190
type: ProteinReference
xref: uniprot Q9VX32 1063
organism: Drosophila melanogaster

MAP kinase-activated protein kinase 2
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot P49138 510
organism: Mus musculus

MAP kinase-activated protein kinase 2
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot P49137 509
organism: Homo sapiens

uniprot Q9LM33 183
type: UnificationXref
id: Q9LM33
db: uniprot

uniprot F1N7C3 519
type: UnificationXref
id: F1N7C3
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot H2Q486 65
organism: Pan troglodytes

uniprot Q7QEQ3 942
type: UnificationXref
id: Q7QEQ3
db: uniprot

uniprot Q7TT37 230
type: UnificationXref
id: Q7TT37
db: uniprot

GRB2 isoform 3
type: ProteinReference
xref: uniprot G2HGD2 248
xref: PTHR46037:SF4
organism: Pan troglodytes

mTOR s58 a155 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q9W0V1 635
organism: Drosophila melanogaster

ACTIVE 18
type: EntityFeature
comment: Active state

TRANSPORT_LEFT__ERK-RIGHT__ERK-_r60
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 1189
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 1190
left: ERK
interaction type: TRANSPORT
right: ERK

PARTICIPANT STOICHIOMETRY r21 1224
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot F7BVQ1 865
organism: Monodelphis domestica

uniprot A0A1D5QE27 746
type: UnificationXref
id: A0A1D5QE27
db: uniprot

uniprot Q8IS21 539
type: UnificationXref
id: Q8IS21
db: uniprot

PARTICIPANT STOICHIOMETRY r35 1155
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r35 1154
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF43
xref: uniprot A0A2I3TPM9 26
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r35 1153
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

uniprot H2KZV6 1008
type: UnificationXref
id: H2KZV6
db: uniprot

GA binding protein transcription factor subunit alpha
type: ProteinReference
xref: uniprot H2R0L6 694
xref: PTHR11849:SF292
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A2I3RG08 1066
xref: PTHR10337:SF4
organism: Pan troglodytes

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF47
xref: uniprot H2QD19 919
organism: Pan troglodytes

Ribosomal protein S6 kinase-like 1
type: ProteinReference
xref: uniprot D4AAT5 36
organism: Rattus norvegicus

uniprot D3ZJW0 665
type: UnificationXref
id: D3ZJW0
db: uniprot

Gene transcription
type: Pathway

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P08487 867
organism: Bos taurus

Glycogen synthase kinase-3
type: ProteinReference
xref: uniprot P51136 365
xref: PTHR24057:SF0
organism: Dictyostelium discoideum

uniprot Q9WUT3 97
type: UnificationXref
id: Q9WUT3
db: uniprot

SLIT-ROBO Rho GTPase activating protein 3
type: ProteinReference
xref: uniprot F1MJI3 981
organism: Bos taurus

uniprot Q9QYY0 270
type: UnificationXref
id: Q9QYY0
db: uniprot

Ninein like
type: ProteinReference
xref: uniprot A0A2I3T332 343
organism: Pan troglodytes

Mitogen-activated protein kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot F1PZ82 504
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r21 1225
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

RCG51408
type: ProteinReference
xref: uniprot D4AB50 974
xref: PTHR12552:SF5
organism: Rattus norvegicus

Ikk s57 a100 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot F6QM53 766
organism: Ornithorhynchus anatinus

Predicted protein
type: ProteinReference
xref: uniprot A7STP5 396
xref: PTHR24070:SF420
organism: Nematostella vectensis

PDGF receptor B s2 a2 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.8120576328758515
comment: MODIFICATION_RESIDUE_NAME=

Guanine nucleotide exchange factor VAV3
type: ProteinReference
xref: PTHR45818:SF1
xref: uniprot Q9R0C8 842
organism: Mus musculus

uniprot A0A1D5R8E9 858
type: UnificationXref
id: A0A1D5R8E9
db: uniprot

uniprot F6WRD7 847
type: UnificationXref
id: F6WRD7
db: uniprot

GA-binding protein alpha chain
type: ProteinReference
xref: uniprot F7E124 687
xref: PTHR11849:SF195
organism: Macaca mulatta

uniprot O60890 1024
type: UnificationXref
id: O60890
db: uniprot

uniprot F1PW15 878
type: UnificationXref
id: F1PW15
db: uniprot

c-Myc-binding protein
type: ProteinReference
xref: PTHR13168:SF0
xref: uniprot A0A452DJ80 875
organism: Bos taurus

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot E2RMD8 42
xref: PTHR24351:SF48
organism: Canis lupus familiaris

uniprot Q7Z6B7 1047
type: UnificationXref
id: Q7Z6B7
db: uniprot

Extracellular signal-regulated kinase 2
type: ProteinReference
xref: PTHR24055:SF79
xref: uniprot Q54QB1 164
organism: Dictyostelium discoideum

uniprot F7DNM3 329
type: UnificationXref
id: F7DNM3
db: uniprot

uniprot O35509 428
type: UnificationXref
id: O35509
db: uniprot

Rho GTPase-activating protein 15
type: ProteinReference
xref: uniprot Q53QZ3 1035
xref: PTHR23176:SF108
organism: Homo sapiens

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 20

uniprot P67999 77
type: UnificationXref
id: P67999
db: uniprot

uniprot V5IKE7 191
type: UnificationXref
id: V5IKE7
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F7GT47 481
xref: PTHR45807:SF1
organism: Macaca mulatta

uniprot H8WGV2 555
type: UnificationXref
id: H8WGV2
db: uniprot

Serum response factor
type: ProteinReference
xref: uniprot F1PH12 200
xref: PTHR48019:SF40
organism: Canis lupus familiaris

Ras-like protein
type: ProteinReference
xref: uniprot P0CQ42 439
xref: PTHR24070:SF17
organism: Cryptococcus neoformans

PARTICIPANT STOICHIOMETRY r79 1122
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E1BCP6 471
xref: PTHR45807:SF1
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r79 1121
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 2.0

Inositol 1,4,5-trisphosphate receptor type 1 isoform 3
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot H9FU38 556
organism: Macaca mulatta

Platelet-derived growth factor receptor alpha
type: ProteinReference
xref: uniprot P20786 515
organism: Rattus norvegicus

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot H9FU32 583
xref: PTHR44329:SF55
organism: Macaca mulatta

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF429
xref: uniprot Q9LM33 183
organism: Arabidopsis thaliana

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F5X1 419
xref: PTHR24070:SF388
organism: Monodelphis domestica

ncbitaxon 9258 52
type: UnificationXref
id: 9258
db: ncbitaxon

Ribosomal protein S6 kinase beta
type: ProteinReference
xref: uniprot Q9NAH6 91
organism: Caenorhabditis elegans

uniprot A6QLK6 240
type: UnificationXref
id: A6QLK6
db: uniprot

Vav guanine nucleotide exchange factor 3
type: ProteinReference
xref: PTHR45818:SF1
xref: uniprot A0A2I3TLP8 825
organism: Pan troglodytes

uniprot Q99417 892
type: UnificationXref
id: Q99417
db: uniprot

PTHR15593:SF2
type: RelationshipXref
id: PTHR15593:SF2
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y6B5 997
organism: Macaca mulatta

PIK3R5 isoform 2
type: ProteinReference
xref: uniprot A0A2J8MGP0 751
xref: PTHR15593:SF2
organism: Pan troglodytes

uniprot F1PMN2 122
type: UnificationXref
id: F1PMN2
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF356
xref: uniprot K7CEN2 147
organism: Pan troglodytes

STAT s127 a172 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.459809653788574
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot F7BTW0 60
type: UnificationXref
id: F7BTW0
db: uniprot

SRF
type: ProteinReference
xref: P01165
standard name: Serum response factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.SRF
comment: ENTITY_REFERENCE_NOTES= Long Name: SRF Synonym: C-FOS SERUM RESPONSE ELEMENT-BINDING FACTOR,SERUM RESPONSE FACTOR Accession: P01165
member entity reference: Serum response factor
member entity reference: Serum response factor homolog
member entity reference: Uncharacterized protein
member entity reference: SRF isoform 1
member entity reference: Serum response factor homolog A

uniprot P42225 924
type: UnificationXref
id: P42225
db: uniprot

uniprot P10686 868
type: UnificationXref
id: P10686
db: uniprot

ncbitaxon 237561 167
type: UnificationXref
id: 237561
db: ncbitaxon

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot E2RCV1 758
organism: Canis lupus familiaris

Ribosomal protein S6 kinase alpha-1
type: ProteinReference
xref: PTHR24351:SF43
xref: uniprot Q15418 81
organism: Homo sapiens

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F6WH53 478
xref: PTHR45807:SF1
organism: Monodelphis domestica

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q5F352 460
organism: Gallus gallus

uniprot F6QUW1 522
type: UnificationXref
id: F6QUW1
db: uniprot

ncbitaxon 9913 28
type: UnificationXref
id: 9913
db: ncbitaxon

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot A0A2I3SYV7 469
xref: PTHR45807:SF1
organism: Pan troglodytes

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot Q02384 530
xref: PTHR23113:SF150
organism: Mus musculus

uniprot A0A2I3SYV7 469
type: UnificationXref
id: A0A2I3SYV7
db: uniprot

Nck s105 a157 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A0A1D5QEF8 954
type: UnificationXref
id: A0A1D5QEF8
db: uniprot

uniprot Q7QEJ7 816
type: UnificationXref
id: Q7QEJ7
db: uniprot

uniprot K7CMU6 1019
type: UnificationXref
id: K7CMU6
db: uniprot

STAT s127 a172 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Oligophrenin-1
type: ProteinReference
xref: uniprot O60890 1024
organism: Homo sapiens

SAM pointed domain-containing Ets transcription factor
type: ProteinReference
xref: uniprot O95238 701
xref: PTHR11849:SF182
organism: Homo sapiens

Mitogen-activated protein kinase 15
type: ProteinReference
xref: PTHR24055:SF414
xref: uniprot Q9C9U4 182
organism: Arabidopsis thaliana

IP3 receptor
type: Protein
entity reference: IP3 receptor
feature: ACTIVE 18
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot F6TYX0 680
type: UnificationXref
id: F6TYX0
db: uniprot

Rho GTPase-activating protein 1
type: ProteinReference
xref: uniprot D4A6C5 973
xref: PTHR45808:SF6
organism: Rattus norvegicus

uniprot A4FV00 109
type: UnificationXref
id: A4FV00
db: uniprot

uniprot Q12706 78
type: UnificationXref
id: Q12706
db: uniprot

Jun proto-oncogene
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot F6RYL1 619
organism: Xenopus tropicalis

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F6R1P6 909
organism: Macaca mulatta

ncbitaxon 7227 95
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot A0A1D5R985 298
type: UnificationXref
id: A0A1D5R985
db: uniprot

Nck
type: Protein
entity reference: Nck
feature: Nck s105 a157 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F1P4Q4 275
type: UnificationXref
id: F1P4Q4
db: uniprot

uniprot F6Q8Z8 986
type: UnificationXref
id: F6Q8Z8
db: uniprot

uniprot F7HHG8 1005
type: UnificationXref
id: F7HHG8
db: uniprot

Serine/threonine-protein kinase N2
type: ProteinReference
xref: PTHR24356:SF322
xref: uniprot Q8BWW9 312
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6R8N9 126
xref: PTHR24055:SF79
organism: Macaca mulatta

ELK s88 a138 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6VXG1 772
organism: Xenopus tropicalis

c-Myc-binding protein
type: ProteinReference
xref: PTHR13168:SF2
xref: uniprot Q99417 892
organism: Homo sapiens

uniprot Q92569 820
type: UnificationXref
id: Q92569
db: uniprot

uniprot F7CB58 416
type: UnificationXref
id: F7CB58
db: uniprot

Mitogen-activated protein kinase 15
type: ProteinReference
xref: PTHR24055:SF79
xref: uniprot Q8TD08 178
organism: Homo sapiens

uniprot Q9JM73 216
type: UnificationXref
id: Q9JM73
db: uniprot

ncbitaxon 227321 114
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot Q39022 163
type: UnificationXref
id: Q39022
db: uniprot

TRANSPORT_LEFT__STAT-RIGHT__STAT-_r79
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 1121
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 1122
left: STAT
interaction type: TRANSPORT
right: STAT

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6ZM17 59
xref: PTHR24351:SF58
organism: Xenopus tropicalis

uniprot F7BYN4 914
type: UnificationXref
id: F7BYN4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot A0A3Q2UD13 543
organism: Gallus gallus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: STAT

ETS2 repressor factor
type: ProteinReference
xref: PTHR11849:SF31
xref: uniprot F1MET2 673
organism: Bos taurus

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 170

uniprot A4GTP4 5
type: UnificationXref
id: A4GTP4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r21
controller: Ras

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot Q6P943 941
xref: PTHR11801:SF18
organism: Danio rerio

uniprot F1Q3M8 765
type: UnificationXref
id: F1Q3M8
db: uniprot

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot B8XIA5 876
xref: PTHR45851:SF1
organism: Macaca mulatta

GTPase NRas
type: ProteinReference
xref: uniprot P01111 430
xref: PTHR24070:SF189
organism: Homo sapiens

uniprot O70142 1070
type: UnificationXref
id: O70142
db: uniprot

GTPase HRas
type: ProteinReference
xref: uniprot P01112 431
xref: PTHR24070:SF385
organism: Homo sapiens

At2g14045
type: ProteinReference
xref: PTHR13168:SF0
xref: uniprot Q8GW13 891
organism: Arabidopsis thaliana

Transcriptional regulator Myc-A
type: ProteinReference
xref: uniprot P52160 886
xref: PTHR45851:SF1
organism: Danio rerio

PDK1 2 s32 a95 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r51 1231
type: Stoichiometry
physical entity: SRF
stoichiometric coefficient: 1.0

uniprot K7C248 1018
type: UnificationXref
id: K7C248
db: uniprot

PTHR24349:SF114
type: RelationshipXref
id: PTHR24349:SF114
db: PANTHER Family
relationship type: By Homology

PTHR24070:SF388
type: RelationshipXref
id: PTHR24070:SF388
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r51 1230
type: Stoichiometry
physical entity: SRF
stoichiometric coefficient: 1.0

PTHR24070:SF385
type: RelationshipXref
id: PTHR24070:SF385
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A2I3RZ31 105
organism: Pan troglodytes

uniprot A8XPY6 242
type: UnificationXref
id: A8XPY6
db: uniprot

uniprot F6PLC7 677
type: UnificationXref
id: F6PLC7
db: uniprot

uniprot Q9CXP4 1059
type: UnificationXref
id: Q9CXP4
db: uniprot

uniprot Q8R4Z4 733
type: UnificationXref
id: Q8R4Z4
db: uniprot

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot P01108 882
xref: PTHR45851:SF1
organism: Mus musculus

uniprot Q7YQL6 1046
type: UnificationXref
id: Q7YQL6
db: uniprot

uniprot Q16513 310
type: UnificationXref
id: Q16513
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: uniprot H2QDK7 66
xref: PTHR24351:SF48
organism: Pan troglodytes

Myc proto-oncogene protein
type: ProteinReference
xref: uniprot P01106 881
xref: PTHR45851:SF1
organism: Homo sapiens

uniprot F1M5M9 978
type: UnificationXref
id: F1M5M9
db: uniprot

uniprot F1MGJ4 904
type: UnificationXref
id: F1MGJ4
db: uniprot

uniprot P22543 796
type: UnificationXref
id: P22543
db: uniprot

Proto-oncogene c-Fos
type: ProteinReference
xref: uniprot P01101 209
xref: PTHR23351:SF4
organism: Mus musculus

Rho GTPase activating protein 1
type: ProteinReference
xref: uniprot F6W5V4 996
xref: PTHR45808:SF6
organism: Monodelphis domestica

uniprot K7CDC2 316
type: UnificationXref
id: K7CDC2
db: uniprot

Proto-oncogene c-Fos
type: ProteinReference
xref: uniprot P01100 208
xref: PTHR23351:SF4
organism: Homo sapiens

PTHR24070:SF380
type: RelationshipXref
id: PTHR24070:SF380
db: PANTHER Family
relationship type: By Homology

E74-like factor 1
type: ProteinReference
xref: uniprot F7B6D9 686
xref: PTHR11849:SF156
organism: Macaca mulatta

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q91Y86 180
xref: PTHR24055:SF222
organism: Mus musculus

uniprot Q90WK2 856
type: UnificationXref
id: Q90WK2
db: uniprot

uniprot Q9YH60 387
type: UnificationXref
id: Q9YH60
db: uniprot

uniprot A4IF90 962
type: UnificationXref
id: A4IF90
db: uniprot

uniprot H2R0L6 694
type: UnificationXref
id: H2R0L6
db: uniprot

uniprot A0A2I3SHP7 859
type: UnificationXref
id: A0A2I3SHP7
db: uniprot

uniprot F6ZM84 776
type: UnificationXref
id: F6ZM84
db: uniprot

uniprot Q6TJY3 85
type: UnificationXref
id: Q6TJY3
db: uniprot

Vav
type: Protein
entity reference: Vav
feature: Vav s108 a160 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot H2R8U9 526
organism: Pan troglodytes

uniprot Q14765 936
type: UnificationXref
id: Q14765
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot R4GIA5 468
organism: Gallus gallus

uniprot F1PIY7 476
type: UnificationXref
id: F1PIY7
db: uniprot

Upstream stimulatory factor 2
type: ProteinReference
xref: uniprot Q63665 213
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HKP4 848
organism: Macaca mulatta

uniprot F6S9S9 601
type: UnificationXref
id: F6S9S9
db: uniprot

uniprot P08642 436
type: UnificationXref
id: P08642
db: uniprot

uniprot Q9WVL2 945
type: UnificationXref
id: Q9WVL2
db: uniprot

uniprot P41162 710
type: UnificationXref
id: P41162
db: uniprot

uniprot A5A6H0 195
type: UnificationXref
id: A5A6H0
db: uniprot

uniprot F1MFS4 979
type: UnificationXref
id: F1MFS4
db: uniprot

Mitogen-activated protein kinase 6
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot P27704 152
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot F7C2C6 134
organism: Monodelphis domestica

Ras homolog family member B
type: ProteinReference
xref: PTHR24072:SF0
xref: uniprot F7FR08 420
organism: Ornithorhynchus anatinus

uniprot Q14643 564
type: UnificationXref
id: Q14643
db: uniprot

ncbitaxon 9544 11
type: UnificationXref
id: 9544
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot F6PGQ1 350
organism: Monodelphis domestica

uniprot F7GT47 481
type: UnificationXref
id: F7GT47
db: uniprot

DShc protein
type: ProteinReference
xref: uniprot Q9V3C8 1082
xref: PTHR10337:SF11
organism: Drosophila melanogaster

uniprot Q1HG70 612
type: UnificationXref
id: Q1HG70
db: uniprot

Elongator complex protein 1
type: ProteinReference
xref: uniprot O95163 228
organism: Homo sapiens

uniprot F6WH53 478
type: UnificationXref
id: F6WH53
db: uniprot

GA-binding protein alpha chain
type: ProteinReference
xref: uniprot Q00422 717
xref: PTHR11849:SF195
organism: Mus musculus

uniprot A8X4K1 346
type: UnificationXref
id: A8X4K1
db: uniprot

PARTICIPANT STOICHIOMETRY r26 1204
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__BAD-_ATP-RIGHT__BAD-_ADP-_r62
controller: PKB

GTPase regulator associated with FAK, isoform G
type: ProteinReference
xref: uniprot X2JDY8 1065
organism: Drosophila melanogaster

uniprot B1H0W5 845
type: UnificationXref
id: B1H0W5
db: uniprot

uniprot P48736 806
type: UnificationXref
id: P48736
db: uniprot

PARTICIPANT STOICHIOMETRY r26 1201
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot P70227 561
type: UnificationXref
id: P70227
db: uniprot

uniprot Q99N57 596
type: UnificationXref
id: Q99N57
db: uniprot

PARTICIPANT STOICHIOMETRY r26 1203
type: Stoichiometry
physical entity: MNK1/2
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR11849:SF216
xref: uniprot A0A1D5Q946 645
organism: Macaca mulatta

uniprot Q5A1D3 166
type: UnificationXref
id: Q5A1D3
db: uniprot

PTHR11462:SF8
type: RelationshipXref
id: PTHR11462:SF8
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r26 1202
type: Stoichiometry
physical entity: MNK1/2
stoichiometric coefficient: 1.0

uniprot F6ZM17 59
type: UnificationXref
id: F6ZM17
db: uniprot

SHC-transforming protein 1
type: ProteinReference
xref: uniprot Q0IIE2 1075
xref: PTHR10337:SF2
organism: Bos taurus

uniprot P52630 932
type: UnificationXref
id: P52630
db: uniprot

CTMP
type: Protein
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q0IIE2 1075
type: UnificationXref
id: Q0IIE2
db: uniprot

Rho GTPase Activating protein
type: ProteinReference
xref: uniprot Q23130 1034
organism: Caenorhabditis elegans

STATE_TRANSITION_LEFT__ATP-_MNK1_2-RIGHT__MNK1_2-_ADP-_r26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 1201
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 1204
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 1203
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 1202
left: MNK1/2
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: MNK1/2

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 79

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot Q68SP3 939
organism: Danio rerio

uniprot P42227 926
type: UnificationXref
id: P42227
db: uniprot

uniprot F1PS03 863
type: UnificationXref
id: F1PS03
db: uniprot

ETS-related transcription factor Elf-5
type: ProteinReference
xref: PTHR11849:SF15
xref: uniprot Q8VDK3 734
organism: Mus musculus

Chromosomal serine/threonine-protein kinase JIL-1
type: ProteinReference
xref: uniprot Q9V3I5 94
organism: Drosophila melanogaster

uniprot Q7RYH5 537
type: UnificationXref
id: Q7RYH5
db: uniprot

Guanine nucleotide exchange factor VAV2
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot Q60992 839
organism: Mus musculus

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: uniprot P26450 799
xref: PTHR10155:SF3
organism: Mus musculus

p90RSK
type: Protein
entity reference: p90RSK
feature: p90RSK s84 a81 rs1
feature: ACTIVE 18
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ETS transcription factor ERG
type: ProteinReference
xref: uniprot A0A0G2JWE9 643
xref: PTHR11849:SF216
organism: Rattus norvegicus

uniprot F1MQE1 46
type: UnificationXref
id: F1MQE1
db: uniprot

GH13542p
type: ProteinReference
xref: uniprot Q8IR23 339
xref: PTHR10194:SF19
organism: Drosophila melanogaster

uniprot Q91Z67 1054
type: UnificationXref
id: Q91Z67
db: uniprot

HRAS isoform 2
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot K7ALD7 425
organism: Pan troglodytes

ncbitaxon 39947 170
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot F7H7W3 63
type: UnificationXref
id: F7H7W3
db: uniprot

uniprot A8XTZ1 861
type: UnificationXref
id: A8XTZ1
db: uniprot

mTOR s65 a152 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q29RS8 724
type: UnificationXref
id: Q29RS8
db: uniprot

uniprot O88351 227
type: UnificationXref
id: O88351
db: uniprot

RAS p21 protein activator 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot F7EPN2 330
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VTR8 771
xref: PTHR15593:SF2
organism: Macaca mulatta

p90RSK
type: ProteinReference
xref: P01142
standard name: Ribosomal protein S6 kinase, 90kD
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: p90RSK Synonym: RIBOSOMAL PROTEIN S6 KINASE,RPS6KA1,RSK1,p90RSK Accession: P01142
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.p90RSK
member entity reference: RPS6KC1 isoform 1
member entity reference: Ribosomal protein S6 kinase
member entity reference: Ribosomal protein S6 kinase alpha-5
member entity reference: Ribosomal protein S6 kinase alpha-3
member entity reference: Ribosomal protein S6 kinase-like 1
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: Ribosomal protein S6 kinase beta
member entity reference: Ribosomal protein S6 kinase beta-1
member entity reference: Ribosomal protein S6 kinase alpha-1
member entity reference: Ribosomal protein S6 kinase 2 alpha
member entity reference: Uncharacterized protein
member entity reference: Putative ribosomal protein S6 kinase alpha-1
member entity reference: Ribosomal protein S6 kinase beta-2
member entity reference: Ribosomal protein S6 kinase alpha-2
member entity reference: Ribosomal protein S6 kinase C1
member entity reference: Chromosomal serine/threonine-protein kinase JIL-1
member entity reference: Ribosomal protein S6 kinase alpha-6
member entity reference: Ribosomal protein S6 kinase alpha-4
member entity reference: Ribosomal protein S6 kinase delta-1
member entity reference: Serine/threonine-protein kinase psk1

uniprot F1NYZ2 600
type: UnificationXref
id: F1NYZ2
db: uniprot

uniprot Q9FVU9 623
type: UnificationXref
id: Q9FVU9
db: uniprot

uniprot H2R0G7 145
type: UnificationXref
id: H2R0G7
db: uniprot

uniprot P28576 853
type: UnificationXref
id: P28576
db: uniprot

uniprot F1NCY7 503
type: UnificationXref
id: F1NCY7
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot F1MX38 905
organism: Bos taurus

uniprot E2RIF9 760
type: UnificationXref
id: E2RIF9
db: uniprot

uniprot P49840 363
type: UnificationXref
id: P49840
db: uniprot

uniprot Q9WTP3 742
type: UnificationXref
id: Q9WTP3
db: uniprot

uniprot J9JHN1 424
type: UnificationXref
id: J9JHN1
db: uniprot

STAT
type: Protein
entity reference: STAT
feature: STAT s123 a173 rs2
feature: STAT s123 a173 rs1
feature: ACTIVE 18

Uncharacterized protein rasC
type: ProteinReference
xref: uniprot F1A411 408
xref: PTHR24070:SF251
organism: Dictyostelium purpureum

uniprot P81270 716
type: UnificationXref
id: P81270
db: uniprot

uniprot Q4G050 291
type: UnificationXref
id: Q4G050
db: uniprot

ETS domain-containing protein Elk-1
type: ProteinReference
xref: uniprot P19419 12
xref: PTHR11849:SF178
organism: Homo sapiens

ETS translocation variant 3
type: ProteinReference
xref: PTHR11849:SF30
xref: uniprot Q8R4Z4 733
organism: Mus musculus

uniprot Q04982 593
type: UnificationXref
id: Q04982
db: uniprot

uniprot Q9W0V1 635
type: UnificationXref
id: Q9W0V1
db: uniprot

Mitogen-activated protein kinase 6
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot Q61532 172
organism: Mus musculus

Ribosomal protein S6 kinase alpha-4
type: ProteinReference
xref: uniprot O75676 71
xref: PTHR24351:SF41
organism: Homo sapiens

uniprot B2RYE0 661
type: UnificationXref
id: B2RYE0
db: uniprot

Rho GTPase-activating protein 10
type: ProteinReference
xref: uniprot Q08DP6 1031
xref: PTHR12552:SF5
organism: Bos taurus

uniprot K7CZM1 528
type: UnificationXref
id: K7CZM1
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot F1MX21 546
organism: Bos taurus

uniprot F6URW3 523
type: UnificationXref
id: F6URW3
db: uniprot

uniprot Q0VCJ7 450
type: UnificationXref
id: Q0VCJ7
db: uniprot

Vav guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot D3ZYG0 826
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7AH39 998
organism: Monodelphis domestica

uniprot Q60680 229
type: UnificationXref
id: Q60680
db: uniprot

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 391

uniprot G7MER6 1006
type: UnificationXref
id: G7MER6
db: uniprot

uniprot E2RL20 580
type: UnificationXref
id: E2RL20
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PDK1_2-RIGHT__PDK1_2-_ADP-_r31
controller: PIP3

Ras-like protein 2
type: ProteinReference
xref: PTHR24070:SF17
xref: uniprot P01120 433
organism: Saccharomyces cerevisiae

uniprot P10398 587
type: UnificationXref
id: P10398
db: uniprot

MAP kinase-interacting serine/threonine-protein kinase 2 isoform 2
type: ProteinReference
xref: uniprot H9EP11 289
xref: PTHR24349:SF254
organism: Macaca mulatta

uniprot Q95KV1 233
type: UnificationXref
id: Q95KV1
db: uniprot

Serine/threonine-protein kinase PKH1
type: ProteinReference
xref: PTHR24356:SF368
xref: uniprot Q03407 629
organism: Saccharomyces cerevisiae

PTHR10336:SF173
type: RelationshipXref
id: PTHR10336:SF173
db: PANTHER Family
relationship type: By Homology

uniprot Q1LZB2 284
type: UnificationXref
id: Q1LZB2
db: uniprot

Platelet-derived growth factor subunit B
type: ProteinReference
xref: uniprot P01127 850
organism: Homo sapiens

FBJ murine osteosarcoma viral oncogene homolog
type: ProteinReference
xref: uniprot F7EI91 202
xref: PTHR23351:SF4
organism: Xenopus tropicalis

uniprot F7FDA0 781
type: UnificationXref
id: F7FDA0
db: uniprot

PARTICIPANT STOICHIOMETRY r27 1199
type: Stoichiometry
physical entity: p90RSK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r27 1198
type: Stoichiometry
physical entity: p90RSK
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot V5IKE7 191
organism: Neurospora crassa

uniprot Q8RUE8 633
type: UnificationXref
id: Q8RUE8
db: uniprot

PARTICIPANT STOICHIOMETRY r27 1197
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Ras-like protein 1
type: ProteinReference
xref: uniprot P01119 432
xref: PTHR24070:SF17
organism: Saccharomyces cerevisiae

MEK
type: Protein
entity reference: MEK
feature: ACTIVE 18
feature: MEK s26 a70 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_r51
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 1231
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 1230
left: SRF
interaction type: STATE_TRANSITION
right: SRF

uniprot Q6Y5D8 1044
type: UnificationXref
id: Q6Y5D8
db: uniprot

uniprot P42230 929
type: UnificationXref
id: P42230
db: uniprot

uniprot Q39021 161
type: UnificationXref
id: Q39021
db: uniprot

Raf homolog serine/threonine-protein kinase
type: ProteinReference
xref: PTHR44329:SF193
xref: uniprot Q07292 594
organism: Caenorhabditis elegans

c-fos
type: Protein
entity reference: c-fos
feature: c fos s96 a118 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot D4A5B9 972
type: UnificationXref
id: D4A5B9
db: uniprot

Complex (PDGF receptor A/PDGF receptor B)
type: Complex
component stoichiometry: PDGF receptor A s5 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: PDGF receptor B s6 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: PDGF s129 a170 STOICHIOMETRY ID COMPLEX
component: PDGF
component: PDGF receptor A
component: PDGF receptor B
feature: COMPLEX BINDING FEATURE s8 a13 1091
feature: COMPLEX BINDING FEATURE s8 a13 1093
feature: COMPLEX BINDING FEATURE s8 a13 1089
cellular location: cytoplasm

uniprot P98077 1073
type: UnificationXref
id: P98077
db: uniprot

p90RSK s80 a84 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r46 1130
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 1206
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot A0A1D5QKT1 646
type: UnificationXref
id: A0A1D5QKT1
db: uniprot

PARTICIPANT STOICHIOMETRY r58 1205
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot F6S9S9 601
organism: Monodelphis domestica

Tyrosine-protein kinase JAK2
type: ProteinReference
xref: uniprot Q62120 489
xref: PTHR45807:SF1
organism: Mus musculus

uniprot J9P9G9 880
type: UnificationXref
id: J9P9G9
db: uniprot

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot F6V946 581
xref: PTHR44329:SF47
organism: Xenopus tropicalis

Ras-related and estrogen-regulated growth inhibitor
type: ProteinReference
xref: uniprot Q96A58 467
organism: Homo sapiens

uniprot Q68SP3 939
type: UnificationXref
id: Q68SP3
db: uniprot

ETS-related transcription factor Elf-2 isoform 1
type: ProteinReference
xref: PTHR11849:SF10
xref: uniprot F7ATZ3 685
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5QUZ8 104
xref: PTHR24055:SF203
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r58 1207
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

uniprot Q5M824 1076
type: UnificationXref
id: Q5M824
db: uniprot

uniprot Q8IS18 538
type: UnificationXref
id: Q8IS18
db: uniprot

PARTICIPANT STOICHIOMETRY r58 1208
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

c fos s98 a117 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot Q61083 171
organism: Mus musculus

uniprot P51023 713
type: UnificationXref
id: P51023
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: c-fos

STATE_TRANSITION_LEFT__STAT-_ATP-RIGHT__STAT-_ADP-_r80
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 1103
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 1104
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 1101
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 1102
left: STAT
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: STAT

PTHR24055:SF158
type: RelationshipXref
id: PTHR24055:SF158
db: PANTHER Family
relationship type: By Homology

RasGAP
type: ProteinReference
xref: P01152
standard name: Ras GTPase-Activating Protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.RasGAP
comment: ENTITY_REFERENCE_NOTES= Long Name: Ras GTPase Activity Protein Synonym: RasGAP Accession: P01152
member entity reference: RAS p21 protein activator 2
member entity reference: GH13542p
member entity reference: Ras GTPase-activating protein 1
member entity reference: Uncharacterized protein
member entity reference: Ras GTPase-activating protein 4
member entity reference: RasGAP-activating-like protein 1
member entity reference: RAS p21 protein activator 1
member entity reference: Ras GTPase-activating protein 4B
member entity reference: RAS p21 protein activator (GTPase activating protein) 1
member entity reference: GTPase-activating protein
member entity reference: AGAP002729-PA
member entity reference: Ras GTPase-activating protein 2

uniprot Q54PQ4 533
type: UnificationXref
id: Q54PQ4
db: uniprot

uniprot P49187 155
type: UnificationXref
id: P49187
db: uniprot

Shaggy-related protein kinase gamma
type: ProteinReference
xref: PTHR24057:SF0
xref: uniprot P43289 362
organism: Arabidopsis thaliana

uniprot E2RE22 903
type: UnificationXref
id: E2RE22
db: uniprot

uniprot B8XIA5 876
type: UnificationXref
id: B8XIA5
db: uniprot

Shaggy-related protein kinase alpha
type: ProteinReference
xref: PTHR24057:SF41
xref: uniprot P43288 361
organism: Arabidopsis thaliana

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: uniprot P16885 869
xref: PTHR10336:SF25
organism: Homo sapiens

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 165

uniprot P42229 928
type: UnificationXref
id: P42229
db: uniprot

uniprot A0A3Q1LQK4 753
type: UnificationXref
id: A0A3Q1LQK4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_ERK-RIGHT__ERK-_ADP-_r23
controller: MEK

uniprot Q39012 370
type: UnificationXref
id: Q39012
db: uniprot

ncbitaxon 44689 165
type: UnificationXref
id: 44689
db: ncbitaxon

RAS p21 protein activator 2
type: ProteinReference
xref: uniprot E2QUM7 325
xref: PTHR10194:SF21
organism: Canis lupus familiaris

uniprot Q22070 871
type: UnificationXref
id: Q22070
db: uniprot

uniprot A0A0G2JZD5 235
type: UnificationXref
id: A0A0G2JZD5
db: uniprot

uniprot Q9VK45 193
type: UnificationXref
id: Q9VK45
db: uniprot

SAM pointed domain-containing Ets transcription factor
type: ProteinReference
xref: uniprot Q9WTP3 742
xref: PTHR11849:SF182
organism: Mus musculus

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: uniprot P67999 77
xref: PTHR24351:SF48
organism: Rattus norvegicus

PTHR24055:SF187
type: RelationshipXref
id: PTHR24055:SF187
db: PANTHER Family
relationship type: By Homology

SLIT-ROBO Rho GTPase activating protein 2
type: ProteinReference
xref: uniprot K7AGG6 1017
organism: Pan troglodytes

uniprot P18652 72
type: UnificationXref
id: P18652
db: uniprot

Platelet-derived growth factor A chain long form
type: ProteinReference
xref: uniprot Q90WK2 856
organism: Gallus gallus

p90RSK s84 a81 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Rho-GTPase-activating protein 8
type: ProteinReference
xref: uniprot Q6AYD8 1042
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__ATP-_Ikk-RIGHT__Ikk-_ADP-_r33
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1161
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1163
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1162
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1164
left: ATP
left: Ikk
interaction type: STATE_TRANSITION
right: ADP
right: Ikk

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
evidence: Evidence 288
xref: uniprot Q9BUB5 296
xref: PTHR24349:SF114
organism: Homo sapiens

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 397

SOS
type: ProteinReference
xref: P01159
standard name: Son of sevenless
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Son of Sevenless Synonym: SON OF SEVENLESS,SOS Accession: P01159
comment: ENTITY_REFERENCE_ID_DESC=PDGF signaling pathway.PROTEIN.GENERIC.SOS
member entity reference: Son of sevenless homolog 2
member entity reference: SOS Ras/Rac guanine nucleotide exchange factor 1
member entity reference: Ras guanine nucleotide exchange factor P
member entity reference: Ras guanine nucleotide exchange factor Y
member entity reference: Ras guanine nucleotide exchange factor B
member entity reference: SOS Ras/Rho guanine nucleotide exchange factor 2
member entity reference: Protein son of sevenless
member entity reference: Ras guanine nucleotide exchange factor E
member entity reference: Cell division control protein 25
member entity reference: Ras guanine nucleotide exchange factor R
member entity reference: Son of sevenless homolog 1
member entity reference: Uncharacterized protein
member entity reference: Ras guanine nucleotide exchange factor A

uniprot F7BRK5 582
type: UnificationXref
id: F7BRK5
db: uniprot

uniprot P16333 283
type: UnificationXref
id: P16333
db: uniprot

Cytoplasmic protein
type: ProteinReference
xref: uniprot Q66IL5 264
organism: Xenopus tropicalis

GRB2-related adapter protein
type: ProteinReference
xref: PTHR46037:SF2
xref: uniprot A6QLK6 240
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot A0A1D5QLW6 857
organism: Macaca mulatta

Tyrosine-protein kinase JAK3
type: ProteinReference
xref: PTHR45807:SF3
xref: uniprot Q62137 490
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y1Z2 683
xref: PTHR11849:SF209
organism: Monodelphis domestica

ERK
type: Protein
entity reference: ERK
feature: ACTIVE 18
feature: ERK s27 a72 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q15853 212
type: UnificationXref
id: Q15853
db: uniprot

Shaggy-related protein kinase delta
type: ProteinReference
xref: uniprot Q9FVS6 378
xref: PTHR24057:SF40
organism: Arabidopsis thaliana

uniprot E2RQM0 862
type: UnificationXref
id: E2RQM0
db: uniprot

Elongator complex protein 1
type: ProteinReference
xref: uniprot Q8VHU4 231
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot H2QLB4 144
organism: Pan troglodytes

ARHGAP42 isoform 2
type: ProteinReference
xref: uniprot H2Q4L7 1010
organism: Pan troglodytes

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: uniprot Q04982 593
xref: PTHR44329:SF47
organism: Gallus gallus

uniprot Q6P8Z1 889
type: UnificationXref
id: Q6P8Z1
db: uniprot

GRB2-associated-binding protein 2
type: ProteinReference
xref: uniprot Q9EQH1 269
organism: Rattus norvegicus

uniprot H2PZQ7 422
type: UnificationXref
id: H2PZQ7
db: uniprot

PARTICIPANT STOICHIOMETRY r46 1127
type: Stoichiometry
physical entity: ELK
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase N2
type: ProteinReference
xref: PTHR24356:SF322
xref: uniprot Q16513 310
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r46 1128
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

ncbitaxon 284812 79
type: UnificationXref
id: 284812
db: ncbitaxon

PTHR24055:SF171
type: RelationshipXref
id: PTHR24055:SF171
db: PANTHER Family
relationship type: By Homology

Rho GTPase-activating protein 12
type: ProteinReference
xref: uniprot Q8C0D4 1051
organism: Mus musculus

ncbitaxon 214684 440
type: UnificationXref
id: 214684
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r46 1129
type: Stoichiometry
physical entity: ELK
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF47
xref: uniprot E2RE22 903
organism: Canis lupus familiaris

uniprot Q9URT9 383
type: UnificationXref
id: Q9URT9
db: uniprot

uniprot P19174 870
type: UnificationXref
id: P19174
db: uniprot

Myc protein
type: ProteinReference
xref: uniprot Q9W4S7 893
xref: PTHR45851:SF3
organism: Drosophila melanogaster

Transcriptional regulator Myc-B
type: ProteinReference
xref: PTHR45851:SF1
xref: uniprot Q7ZVS9 890
organism: Danio rerio

uniprot F7BD31 831
type: UnificationXref
id: F7BD31
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_STAT-RIGHT__STAT-_ADP-_r17
controller: Jak

PDGF receptor B
type: Protein
entity reference: PDGF receptor B
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa4 1094
feature: ACTIVE 18
feature: PDGF receptor B s6 sa4 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot D4A3M8 273
type: UnificationXref
id: D4A3M8
db: uniprot

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P17252 305
organism: Homo sapiens

ncbitaxon 665079 112
type: UnificationXref
id: 665079
db: ncbitaxon

uniprot Q54TY7 642
type: UnificationXref
id: Q54TY7
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot Q9VXH3 874
organism: Drosophila melanogaster

uniprot H2R8U9 526
type: UnificationXref
id: H2R8U9
db: uniprot

uniprot F6QGZ1 987
type: UnificationXref
id: F6QGZ1
db: uniprot

COP9 signalosome complex subunit 5b
type: ProteinReference
xref: uniprot Q9FVU9 623
organism: Arabidopsis thaliana

Platelet-derived growth factor receptor alpha
type: ProteinReference
xref: uniprot P16234 514
organism: Homo sapiens

uniprot F6TVC2 992
type: UnificationXref
id: F6TVC2
db: uniprot

uniprot E2R2N2 117
type: UnificationXref
id: E2R2N2
db: uniprot

uniprot F7GRE8 1001
type: UnificationXref
id: F7GRE8
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

Rho GTPase-activating protein 26
type: ProteinReference
xref: PTHR12552:SF4
xref: uniprot Q6ZQ82 1045
organism: Mus musculus

TRANSPORT
type: InteractionVocabulary

uniprot E1BN61 39
type: UnificationXref
id: E1BN61
db: uniprot

PTHR24055:SF196
type: RelationshipXref
id: PTHR24055:SF196
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F7DKS0 480
xref: PTHR45807:SF5
organism: Xenopus tropicalis

Rho GTPase-activating protein 15
type: ProteinReference
xref: PTHR23176:SF108
xref: uniprot Q6AYC5 1041
organism: Rattus norvegicus

uniprot F6SZ66 768
type: UnificationXref
id: F6SZ66
db: uniprot

Rho GTPase-activating protein 26
type: ProteinReference
xref: PTHR12552:SF4
xref: uniprot Q9UNA1 1061
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GSK3-_ATP-RIGHT__GSK3-_ADP-_r61
controller: PKB

ADP
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P26323 705
type: UnificationXref
id: P26323
db: uniprot

uniprot A0A1D5NVQ5 823
type: UnificationXref
id: A0A1D5NVQ5
db: uniprot

RAS p21 protein activator 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot E9PYG6 326
organism: Mus musculus

uniprot O43639 281
type: UnificationXref
id: O43639
db: uniprot

uniprot F1QWX8 477
type: UnificationXref
id: F1QWX8
db: uniprot

Extracellular signal-regulated kinase 1
type: ProteinReference
xref: uniprot Q5A1D3 166
xref: PTHR24055:SF158
organism: Candida albicans

uniprot A0A1D5QLW6 857
type: UnificationXref
id: A0A1D5QLW6
db: uniprot

ETS homologous factor
type: ProteinReference
xref: PTHR11849:SF171
xref: uniprot F6PQA3 678
organism: Ornithorhynchus anatinus

Tyrosine-protein kinase JAK1
type: ProteinReference
xref: uniprot O12990 484
xref: PTHR45807:SF5
organism: Danio rerio

STATE_TRANSITION_LEFT__c_Myc-_ATP-RIGHT__c_Myc-_ADP-_r48
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1120
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1117
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1119
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1118
left: c-Myc
left: ATP
interaction type: STATE_TRANSITION
right: c-Myc
right: ADP

Jun proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot E2R6T4 618
organism: Canis lupus familiaris

Protein vav
type: ProteinReference
xref: uniprot Q9NHV9 841
organism: Drosophila melanogaster

uniprot C8V7D1 113
type: UnificationXref
id: C8V7D1
db: uniprot

uniprot P29993 558
type: UnificationXref
id: P29993
db: uniprot

uniprot Q6P0S4 215
type: UnificationXref
id: Q6P0S4
db: uniprot

uniprot Q9UBS0 92
type: UnificationXref
id: Q9UBS0
db: uniprot

uniprot F6YE27 684
type: UnificationXref
id: F6YE27
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
type: ProteinReference
xref: uniprot F7BZL6 777
xref: PTHR10155:SF3
organism: Macaca mulatta

uniprot F6X927 222
type: UnificationXref
id: F6X927
db: uniprot

uniprot Q9SJG9 186
type: UnificationXref
id: Q9SJG9
db: uniprot

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 124

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: uniprot O46404 794
xref: PTHR10155:SF2
organism: Bos taurus

uniprot F1M9D0 120
type: UnificationXref
id: F1M9D0
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E2RPW6 473
xref: PTHR45807:SF1
organism: Canis lupus familiaris

uniprot Q3UPW2 726
type: UnificationXref
id: Q3UPW2
db: uniprot

uniprot A0A2J8LNE4 237
type: UnificationXref
id: A0A2J8LNE4
db: uniprot

STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_Pi-_r24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 1213
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 1214
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 1215
left: Ras
interaction type: STATE_TRANSITION
right: Pi
right: Ras

uniprot P26675 529
type: UnificationXref
id: P26675
db: uniprot

PARTICIPANT STOICHIOMETRY r65 1166
type: Stoichiometry
physical entity: MAPKAPK2
stoichiometric coefficient: 1.0

uniprot A5PMP7 844
type: UnificationXref
id: A5PMP7
db: uniprot

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF16
xref: uniprot E2RHV6 274
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r65 1165
type: Stoichiometry
physical entity: MAPKAPK2
stoichiometric coefficient: 1.0

uniprot F6Z5N3 414
type: UnificationXref
id: F6Z5N3
db: uniprot

uniprot Q10664 611
type: UnificationXref
id: Q10664
db: uniprot

uniprot F6YCI3 524
type: UnificationXref
id: F6YCI3
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF48
xref: uniprot F6UMM2 912
organism: Macaca mulatta

uniprot A5A6H2 196
type: UnificationXref
id: A5A6H2
db: uniprot

PIK3CG isoform 1
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot A0A2J8QY32 752
organism: Pan troglodytes

uniprot F1MFK1 299
type: UnificationXref
id: F1MFK1
db: uniprot

Ras guanine nucleotide exchange factor Y
type: ProteinReference
xref: uniprot Q552M5 535
organism: Dictyostelium discoideum

uniprot Q6P023 175
type: UnificationXref
id: Q6P023
db: uniprot

E74 like ETS transcription factor 2
type: ProteinReference
xref: PTHR11849:SF10
xref: uniprot A0A2I3RCF6 648
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H5F6 1003
organism: Macaca mulatta

MAP kinase-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: PTHR24349:SF114
xref: uniprot Q58D94 292
organism: Bos taurus

Ras-related protein Rab-11B
type: ProteinReference
xref: uniprot Q15907 452
organism: Homo sapiens

uniprot F1LWB1 829
type: UnificationXref
id: F1LWB1
db: uniprot

uniprot Q5FVG6 1036
type: UnificationXref
id: Q5FVG6
db: uniprot