Insulin-like growth factor-binding protein 1
type: DnaReference
xref: PTHR11551:SF6
organism: Pan troglodytes

FOXO
type: ProteinReference
xref: P01198
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.FOXO
comment: ENTITY_REFERENCE_NOTES= Long Name: FOXO Synonym: DAF-16,DAF_16,FKHRL1,FKHRL2,FKHRL3,FKHRL4,Forkhead box subgroup "O" protein,Forkhead transcription factor Accession: P01198
member entity reference: Forkhead box protein O1
member entity reference: Forkhead box O4
member entity reference: FOXO3 isoform 1
member entity reference: Forkhead box O1
member entity reference: Uncharacterized protein
member entity reference: Forkhead box protein O4
member entity reference: Forkhead box protein O3
member entity reference: FOXO1 isoform 1
member entity reference: Forkhead box O3

PDK1 ACT
type: Protein
entity reference: PDK1 ACT
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa23 467
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Insulin-like growth factor-binding protein 1
type: DnaReference
organism: Rattus norvegicus

G protein subunit alpha i3
type: ProteinReference
xref: uniprot H2PZK9 320
organism: Pan troglodytes

Gbetagamma
type: Protein
entity reference: Gbetagamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s64 sa58 535
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 2

ncbitaxon 7719 355
type: UnificationXref
id: 7719
db: ncbitaxon

uniprot P04899 327
type: UnificationXref
id: P04899
db: uniprot

uniprot A0A2I3RFV3 150
type: UnificationXref
id: A0A2I3RFV3
db: uniprot

PTHR24351:SF200
type: RelationshipXref
id: PTHR24351:SF200
db: PANTHER Family
relationship type: By Homology

G protein subunit alpha i1
type: ProteinReference
xref: uniprot F1P977 306
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r42 621
type: Stoichiometry
physical entity: PDK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r42 620
type: Stoichiometry
physical entity: PI(3,4,5)P3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r42 622
type: Stoichiometry
physical entity: Complex (PI(3,4,5)P3/PDK1)
stoichiometric coefficient: 1.0

Caspase-9
type: ProteinReference
xref: PTHR10454:SF157
xref: uniprot P55211 275
organism: Homo sapiens

uniprot F1PRG4 74
type: UnificationXref
id: F1PRG4
db: uniprot

G protein subunit alpha transducin 2
type: ProteinReference
xref: uniprot H2PZL0 321
organism: Pan troglodytes

uniprot A0A1D5PX66 359
type: UnificationXref
id: A0A1D5PX66
db: uniprot

p85
type: Protein
entity reference: p85
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa38 551
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot O15530 43
type: UnificationXref
id: O15530
db: uniprot

uniprot P42338 49
type: UnificationXref
id: P42338
db: uniprot

PARTICIPANT STOICHIOMETRY r76 611
type: Stoichiometry
physical entity: Complex (GPCR ligand/GPCR/ Galpha/Gbetagamma)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r76 610
type: Stoichiometry
physical entity: Complex (GPCR/Galpha/ Gbetagamma)
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(T) subunit gamma-T1
type: ProteinReference
xref: PTHR13809:SF26
xref: uniprot P63211 216
organism: Homo sapiens

Guanine nucleotide-binding protein G(T) subunit gamma-T1
type: ProteinReference
xref: PTHR13809:SF26
xref: uniprot P63210 215
organism: Canis lupus familiaris

uniprot O95837 324
type: UnificationXref
id: O95837
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 19

uniprot H2PZK9 320
type: UnificationXref
id: H2PZK9
db: uniprot

uniprot F6XW91 418
type: UnificationXref
id: F6XW91
db: uniprot

Insulin receptor substrate 1
type: ProteinReference
xref: uniprot F1MYE0 249
xref: PTHR10614:SF11
organism: Bos taurus

PKB s23 sa25 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.12
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot O43524 289
type: UnificationXref
id: O43524
db: uniprot

IR ligand s30 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IR ligand
stoichiometric coefficient: 1.0

GPCR s66 sa60 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GPCR
stoichiometric coefficient: 1.0

uniprot P63210 215
type: UnificationXref
id: P63210
db: uniprot

ncbitaxon 559292 117
type: UnificationXref
id: 559292
db: ncbitaxon

Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)
type: ProteinReference
xref: uniprot Q5RKP9 350
organism: Danio rerio

uniprot P54313 207
type: UnificationXref
id: P54313
db: uniprot

Ras s6 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

Galpha
type: Protein
entity reference: Galpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s213 sa57 533
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P15127 155
type: UnificationXref
id: P15127
db: uniprot

uniprot F6PGQ1 97
type: UnificationXref
id: F6PGQ1
db: uniprot

NOS
type: Protein
entity reference: NOS
feature: NOS s137 a277 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

IR s29 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IR
stoichiometric coefficient: 1.0

PKB s25 sa27 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.12
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot P03967 119
type: UnificationXref
id: P03967
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F1Q118 138
organism: Canis lupus familiaris

PTHR10218:SF316
type: RelationshipXref
id: PTHR10218:SF316
db: PANTHER Family
relationship type: By Homology

NOS s137 a277 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.74

PARTICIPANT STOICHIOMETRY r35 645
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 125

uniprot P29474 409
type: UnificationXref
id: P29474
db: uniprot

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot H9ENT4 266
organism: Macaca mulatta

uniprot P62873 210
type: UnificationXref
id: P62873
db: uniprot

ncbitaxon 3702 203
type: UnificationXref
id: 3702
db: ncbitaxon

HETERODIMER_ASSOCIATION_LEFT__p85-_p110-RIGHT__Complex__p85_p110_-_r27
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 661
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 663
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 662
left: p85
left: p110
interaction type: HETERODIMER_ASSOCIATION
right: Complex (p85/p110)

JAK receptor
type: Protein
feature: JAK receptor s72 a122 rs2
feature: JAK receptor s72 a122 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r19 572
type: Stoichiometry
physical entity: PI(4,5)P2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r19 573
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

3-phosphoinositide dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot A0A2I3TN41 26
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r19 571
type: Stoichiometry
physical entity: PI(3,4,5)P3
stoichiometric coefficient: 1.0

NRAS protein
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot A5D7R9 108
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r35 648
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r35 647
type: Stoichiometry
physical entity: Complex (Ras/GTP)
stoichiometric coefficient: 1.0

PTHR10218:SF328
type: RelationshipXref
id: PTHR10218:SF328
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r35 646
type: Stoichiometry
physical entity: Complex (GDP/Ras)
stoichiometric coefficient: 1.0

PTHR10218:SF329
type: RelationshipXref
id: PTHR10218:SF329
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r70 637
type: Stoichiometry
physical entity: Complex (ITK ligand/Int Tyr Kin)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QK27 273
xref: PTHR10454:SF157
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r70 639
type: Stoichiometry
physical entity: Complex (ITK ligand/Int Tyr Kin/ Grb2)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r70 638
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot F7CTP1 181
xref: PTHR19850:SF31
organism: Macaca mulatta

Complex (IR ligand/IR/ IRS/p85/ p110)
type: Complex
component stoichiometry: IR ligand s34 sa35 STOICHIOMETRY ID COMPLEX
component stoichiometry: IRS s36 sa37 STOICHIOMETRY ID COMPLEX
component stoichiometry: IR s35 sa36 STOICHIOMETRY ID COMPLEX
component stoichiometry: p85 s37 sa38 STOICHIOMETRY ID COMPLEX
component stoichiometry: p110 s39 sa39 STOICHIOMETRY ID COMPLEX
component: IR
component: p85
component: IR ligand
component: IRS
component: p110
feature: COMPLEX BINDING FEATURE s160 a326 544
feature: COMPLEX BINDING FEATURE s160 a326 548
feature: COMPLEX BINDING FEATURE s160 a326 552
feature: ACTIVE 59
feature: COMPLEX BINDING FEATURE s160 a326 546
feature: COMPLEX BINDING FEATURE s160 a326 550
cellular location: cytoplasm

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot Q9Z1L0 57
organism: Rattus norvegicus

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P79737 127
organism: Danio rerio

uniprot Q07889 147
type: UnificationXref
id: Q07889
db: uniprot

PI 3,4,5 P3 s15 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PI(3,4,5)P3
stoichiometric coefficient: 1.0

Inositol polyphosphate-5-phosphatase A
type: ProteinReference
xref: uniprot A0A2I3TRE1 361
organism: Pan troglodytes

PTHR24356:SF333
type: RelationshipXref
id: PTHR24356:SF333
db: PANTHER Family
relationship type: By Homology

Ras protein let-60
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot P22981 126
organism: Caenorhabditis elegans

uniprot Q6PC73 66
type: UnificationXref
id: Q6PC73
db: uniprot

STATE_TRANSITION_LEFT__ATP-_Complex__JAK_receptor_JAK_Ligand_-RIGHT__ADP-_Complex__JAK_Ligand_JAK_receptor_-_r80
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 562
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 564
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 561
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 563
left: ATP
left: Complex (JAK receptor/JAK Ligand)
interaction type: STATE_TRANSITION
right: ADP
right: Complex (JAK Ligand/JAK receptor)

Ribosomal protein S6 kinase beta-2
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot Q9Z1M4 272
organism: Mus musculus

uniprot F1MV64 152
type: UnificationXref
id: F1MV64
db: uniprot

Insulin receptor substrate 1
type: ProteinReference
xref: uniprot Q9XTN2 254
xref: PTHR10614:SF13
organism: Drosophila melanogaster

Guanine nucleotide-binding protein subunit beta-5a
type: ProteinReference
xref: PTHR19850:SF40
xref: uniprot A1L271 160
organism: Danio rerio

uniprot F7FXA9 185
type: UnificationXref
id: F7FXA9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot E2RPB0 378
organism: Canis lupus familiaris

uniprot F7CQS0 263
type: UnificationXref
id: F7CQS0
db: uniprot

PARTICIPANT STOICHIOMETRY r48 593
type: Stoichiometry
physical entity: Complex (PI(3,4,5)P3/PKB)
stoichiometric coefficient: 1.0

G protein subunit alpha 14
type: ProteinReference
xref: uniprot A0A2I3TRC4 297
xref: PTHR10218:SF213
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r48 592
type: Stoichiometry
physical entity: Complex (PI(3,4,5)P3/PKB)
stoichiometric coefficient: 1.0

uniprot F6UK84 261
type: UnificationXref
id: F6UK84
db: uniprot

uniprot O55173 45
type: UnificationXref
id: O55173
db: uniprot

PARTICIPANT STOICHIOMETRY r48 594
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

NRAS proto-oncogene, GTPase
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot F1PHV7 112
organism: Canis lupus familiaris

uniprot Q59XU5 130
type: UnificationXref
id: Q59XU5
db: uniprot

uniprot Q968Y9 157
type: UnificationXref
id: Q968Y9
db: uniprot

uniprot A9JTC8 299
type: UnificationXref
id: A9JTC8
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot E7EXT6 72
organism: Danio rerio

NRAS isoform 1
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot H2PZQ7 114
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r48 591
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

JAK receptor s81 sa74 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JAK receptor
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7DUD6 35
xref: PTHR10048:SF107
organism: Ornithorhynchus anatinus

Int Tyr Kin s41 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Int Tyr Kin
stoichiometric coefficient: 1.0

uniprot X1WDQ5 358
type: UnificationXref
id: X1WDQ5
db: uniprot

Cyclin d
type: DnaRegionReference
member entity reference: G1/S-specific cyclin-D2
member entity reference: Cyclin D1
member entity reference: CCND2 isoform 1
member entity reference: G1/S-specific cyclin-D1
xref: G01546
comment: ENTITY_REFERENCE_NOTES= Long Name: Cyclin d Synonym: PRAD1: parathyroid adenomatosis 1 Accession: G01546
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.GENE.GENE.Cyclin d

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6QP11 77
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r4 600
type: Stoichiometry
physical entity: Complex (p85/p110)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r55 670
type: Stoichiometry
physical entity: FOXO
stoichiometric coefficient: 1.0

uniprot P09208 154
type: UnificationXref
id: P09208
db: uniprot

uniprot P50149 342
type: UnificationXref
id: P50149
db: uniprot

PARTICIPANT STOICHIOMETRY r55 671
type: Stoichiometry
physical entity: Complex (FOXO/14-3-3)
stoichiometric coefficient: 1.0

uniprot O08586 241
type: UnificationXref
id: O08586
db: uniprot

uniprot P23727 389
type: UnificationXref
id: P23727
db: uniprot

uniprot Q9WV60 103
type: UnificationXref
id: Q9WV60
db: uniprot

uniprot Q9WVH3 293
type: UnificationXref
id: Q9WVH3
db: uniprot

Si:dkeyp-80c12.7
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot B8JIQ1 95
organism: Danio rerio

ncbitaxon 237561 131
type: UnificationXref
id: 237561
db: ncbitaxon

Ras
type: ProteinReference
xref: P01182
standard name: Ras-GDP
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.Ras
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Uncharacterized protein rasD
member entity reference: Ras-like protein 2
member entity reference: GTPase NRas
member entity reference: NRAS isoform 1
member entity reference: Ras-like protein 1
member entity reference: NRAS proto-oncogene, GTPase
member entity reference: -Ha-ras Harvey rat sarcoma viral oncogene homolog, like
member entity reference: Ras-like protein rasD
member entity reference: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
member entity reference: Protein CBR-LET-60
member entity reference: HRas proto-oncogene, GTPase a
member entity reference: NRAS protein
member entity reference: Protein ras-1
member entity reference: Ras protein let-60

PARTICIPANT STOICHIOMETRY r7 577
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 576
type: Stoichiometry
physical entity: PI(3,4,5)P3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 575
type: Stoichiometry
physical entity: PI(4,5)P2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 574
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r56 664
type: Stoichiometry
physical entity: FOXO
stoichiometric coefficient: 1.0

uniprot E2R7K9 257
type: UnificationXref
id: E2R7K9
db: uniprot

PARTICIPANT STOICHIOMETRY r56 665
type: Stoichiometry
physical entity: FOXO
stoichiometric coefficient: 1.0

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F7BWW9 142
organism: Ornithorhynchus anatinus

uniprot P50154 204
type: UnificationXref
id: P50154
db: uniprot

PTHR46051:SF2
type: RelationshipXref
id: PTHR46051:SF2
db: PANTHER Family
relationship type: By Homology

uniprot Q66JF0 351
type: UnificationXref
id: Q66JF0
db: uniprot

PTHR46037:SF4
type: RelationshipXref
id: PTHR46037:SF4
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot Q9JID2 357
organism: Rattus norvegicus

00696
type: UnificationXref
id: MOD:00696
db: mod

uniprot E1BLQ5 256
type: UnificationXref
id: E1BLQ5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Complex__PI_3,4,5_P3_PKB_-RIGHT__Complex__PI_3,4,5_P3_PKB_-_ADP-_r48
controller: Complex (PI(3,4,5)P3/PDK1 ACT)

PTHR46037:SF1
type: RelationshipXref
id: PTHR46037:SF1
db: PANTHER Family
relationship type: By Homology

uniprot F6VBA7 239
type: UnificationXref
id: F6VBA7
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: uniprot G7MGQ5 383
xref: PTHR10155:SF2
organism: Macaca mulatta

G protein subunit alpha i2
type: ProteinReference
xref: uniprot H2QMN4 322
organism: Pan troglodytes

p101
type: ProteinReference
xref: P01203
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: p101 Synonym: Class IB PI3 Kinase,Class IB phosphoinositol 3-kinase Accession: P01203
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.p101
member entity reference: Uncharacterized protein
member entity reference: Phosphoinositide 3-kinase regulatory subunit 5
member entity reference: Phosphoinositide-3-kinase regulatory subunit 5
member entity reference: PIK3R5 isoform 2

STATE_TRANSITION_LEFT__FOXO-_ATP-RIGHT__ADP-_FOXO-_r54
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 677
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 676
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 675
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 678
left: ATP
left: FOXO
interaction type: STATE_TRANSITION
right: ADP
right: FOXO

GSK3
type: Protein
entity reference: GSK3
feature: GSK3 s131 a268 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot D3ZZX1 363
type: UnificationXref
id: D3ZZX1
db: uniprot

PTHR19850:SF27
type: RelationshipXref
id: PTHR19850:SF27
db: PANTHER Family
relationship type: By Homology

PDK1
type: ProteinReference
xref: P01196
standard name: 3-phosphoinositide-dependent protein kinase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.PDK1
comment: ENTITY_REFERENCE_NOTES= Long Name: PDK1 Synonym: 3-phosphoinositide dependent kinase 1 Accession: P01196
member entity reference: 3-phosphoinositide-dependent protein kinase 1
member entity reference: Uncharacterized protein
member entity reference: 3-phosphoinositide dependent protein kinase 1

PTHR19850:SF25
type: RelationshipXref
id: PTHR19850:SF25
db: PANTHER Family
relationship type: By Homology

uniprot F6ZVZ0 284
type: UnificationXref
id: F6ZVZ0
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__ITK_ligand_Int_Tyr_Kin_-_Grb2-RIGHT__Complex__ITK_ligand_Int_Tyr_Kin__Grb2_-_r70
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 639
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 637
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 638
left: Grb2
left: Complex (ITK ligand/Int Tyr Kin)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (ITK ligand/Int Tyr Kin/ Grb2)

uniprot Q5F352 132
type: UnificationXref
id: Q5F352
db: uniprot

DISSOCIATION
type: RelationshipTypeVocabulary

p101
type: Protein
entity reference: p101
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa19 543
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR19850:SF29
type: RelationshipXref
id: PTHR19850:SF29
db: PANTHER Family
relationship type: By Homology

PTHR19850:SF28
type: RelationshipXref
id: PTHR19850:SF28
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase receptor
type: ProteinReference
xref: PTHR24416:SF535
xref: uniprot E2RPM8 151
organism: Canis lupus familiaris

scl-1
type: DnaRegion
entity reference: scl-1
cellular location: nucleus
comment: SPECIES_TYPE=GENE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Ras_GDP_-_GTP-RIGHT__Complex__Ras_GTP_-_GDP-_r34
controller: SOS

uniprot F6QUW1 139
type: UnificationXref
id: F6QUW1
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: PTHR13809:SF28
xref: uniprot P50154 204
organism: Bos taurus

uniprot P52287 205
type: UnificationXref
id: P52287
db: uniprot

TRANSCRIPTION_LEFT__GADD45-RIGHT__GADD45-_re50
type: TemplateReaction
product: GADD45
xref: TRANSCRIPTION
participant: GADD45
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: uniprot P50148 341
xref: PTHR10218:SF316
organism: Homo sapiens

uniprot F6WH53 12
type: UnificationXref
id: F6WH53
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot P50146 340
organism: Gallus gallus

Guanine nucleotide-binding protein G(t) subunit alpha-2
type: ProteinReference
xref: uniprot P50149 342
organism: Mus musculus

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot E2R7K9 257
organism: Canis lupus familiaris

uniprot F1P4J0 259
type: UnificationXref
id: F1P4J0
db: uniprot

uniprot H2Q486 264
type: UnificationXref
id: H2Q486
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Complex__JAK_receptor_JAK_Ligand_-RIGHT__ADP-_Complex__JAK_Ligand_JAK_receptor_-_r80
controller: JAK

HETERODIMER_ASSOCIATION_LEFT__Complex__IR_ligand_IR_-_IRS-RIGHT__Complex__IR_ligand_IR__IRS_-_r66
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 655
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 654
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 653
left: IRS
left: Complex (IR ligand/IR)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (IR ligand/IR/ IRS)

PTHR19850:SF40
type: RelationshipXref
id: PTHR19850:SF40
db: PANTHER Family
relationship type: By Homology

uniprot Q17941 88
type: UnificationXref
id: Q17941
db: uniprot

uniprot P35375 402
type: UnificationXref
id: P35375
db: uniprot

Complex (IR ligand/IR)
type: Complex
component stoichiometry: IR s29 sa31 STOICHIOMETRY ID COMPLEX
component stoichiometry: IR ligand s28 sa30 STOICHIOMETRY ID COMPLEX
component: IR ligand
component: IR
feature: COMPLEX BINDING FEATURE s155 a309 456
feature: COMPLEX BINDING FEATURE s155 a309 458
cellular location: cytoplasm

Glycogen synthase kinase 3
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot Q9YH60 104
organism: Danio rerio

HETERODIMER_ASSOCIATION_LEFT__p85-_p110-RIGHT__Complex__p85_p110_-_r23
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 668
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 667
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 666
left: p85
left: p110
interaction type: HETERODIMER_ASSOCIATION
right: Complex (p85/p110)

PKB
type: Protein
entity reference: PKB
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa27 449
feature: PKB s25 sa27 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F1MYM3 27
type: UnificationXref
id: F1MYM3
db: uniprot

uniprot E2RDB5 248
type: UnificationXref
id: E2RDB5
db: uniprot

uniprot Q7Q6D2 228
type: UnificationXref
id: Q7Q6D2
db: uniprot

Ras-like protein 1
type: ProteinReference
xref: uniprot Q59XU5 130
xref: PTHR24070:SF17
organism: Candida albicans

uniprot O62699 408
type: UnificationXref
id: O62699
db: uniprot

Complex (ITK ligand/Int Tyr Kin)
type: Complex
component stoichiometry: Int Tyr Kin s50 sa46 STOICHIOMETRY ID COMPLEX
component stoichiometry: ITK ligand s46 sa45 STOICHIOMETRY ID COMPLEX
component: Int Tyr Kin
component: ITK ligand
feature: COMPLEX BINDING FEATURE s167 a341 514
feature: COMPLEX BINDING FEATURE s167 a341 516
cellular location: cytoplasm

Growth factor receptor-bound protein 2a
type: ProteinReference
xref: PTHR46037:SF4
xref: uniprot Q5RKN6 64
organism: Danio rerio

SOS
type: ProteinReference
xref: P01185
standard name: Son of sevenless
comment: ENTITY_REFERENCE_NOTES= Long Name: SOS Synonym: Son of sevenless Accession: P01185
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.SOS
member entity reference: SOS Ras/Rac guanine nucleotide exchange factor 1
member entity reference: Son of sevenless homolog 2
member entity reference: Uncharacterized protein
member entity reference: SOS Ras/Rho guanine nucleotide exchange factor 2
member entity reference: Son of sevenless homolog 1

PTHR19850:SF30
type: RelationshipXref
id: PTHR19850:SF30
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Complex__JAK_Ligand_JAK_receptor_-RIGHT__ADP-_Complex__JAK_Ligand_JAK_receptor_-_r82
controller: JAK

G1/S-specific cyclin-D1
type: DnaReference
xref: PTHR10177:SF67
organism: Rattus norvegicus

PTHR19850:SF36
type: RelationshipXref
id: PTHR19850:SF36
db: PANTHER Family
relationship type: By Homology

PTHR10155:SF3
type: RelationshipXref
id: PTHR10155:SF3
db: PANTHER Family
relationship type: By Homology

Complex (PI(3,4,5)P3/PKB)
type: Complex
component stoichiometry: PI 3,4,5 P3 s24 sa26 STOICHIOMETRY ID COMPLEX
component stoichiometry: PKB s25 sa27 STOICHIOMETRY ID COMPLEX
component: PI(3,4,5)P3
component: PKB
feature: COMPLEX BINDING FEATURE s127 a255 446
feature: COMPLEX BINDING FEATURE s127 a255 448
cellular location: cytoplasm

PTHR19850:SF31
type: RelationshipXref
id: PTHR19850:SF31
db: PANTHER Family
relationship type: By Homology

FOXO1 isoform 1
type: ProteinReference
xref: PTHR45767:SF1
xref: uniprot H2Q7G4 286
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q2U4X3 70
xref: PTHR24356:SF171
organism: Gallus gallus

uniprot H2PZQ7 114
type: UnificationXref
id: H2PZQ7
db: uniprot

PTHR10155:SF2
type: RelationshipXref
id: PTHR10155:SF2
db: PANTHER Family
relationship type: By Homology

PTHR10155:SF1
type: RelationshipXref
id: PTHR10155:SF1
db: PANTHER Family
relationship type: By Homology

scl-1
type: DnaRegionReference
member entity reference: SCP-Like extracellular protein
xref: G01545
comment: ENTITY_REFERENCE_NOTES= Long Name: scl-1 Synonym: Synonym not specified Accession: G01545
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.GENE.GENE.scl-1

uniprot P60484 244
type: UnificationXref
id: P60484
db: uniprot

G01546
type: UnificationXref
id: G01546
db: PANTHER Pathway Component

G01545
type: UnificationXref
id: G01545
db: PANTHER Pathway Component

G01544
type: UnificationXref
id: G01544
db: PANTHER Pathway Component

G01543
type: UnificationXref
id: G01543
db: PANTHER Pathway Component

SCP-Like extracellular protein
type: DnaReference
organism: Caenorhabditis elegans

SCP-Like extracellular protein
type: DnaReference
organism: Caenorhabditis elegans

p110
type: ProteinReference
xref: P01192
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: p110 Synonym: Class IA PI3K catalytic subunit Accession: P01192
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.p110
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
member entity reference: PI-3 kinase

Uncharacterized protein rasD
type: ProteinReference
xref: PTHR24070:SF418
xref: uniprot F0ZB76 110
organism: Dictyostelium purpureum

Galpha
type: ProteinReference
xref: P01199
standard name: G-protein, alpha subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.G_sub__alpha_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)
member entity reference: Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
member entity reference: G protein subunit alpha 14
member entity reference: Guanine nucleotide-binding protein G(K) subunit alpha
member entity reference: GNAI2 protein
member entity reference: Guanine nucleotide-binding protein G(q) subunit alpha
member entity reference: Uncharacterized protein
member entity reference: G protein subunit alpha q
member entity reference: Guanine nucleotide-binding protein subunit alpha-11
member entity reference: Guanine nucleotide-binding protein G(t) subunit alpha-2
member entity reference: Guanine nucleotide-binding protein (G protein), q polypeptide
member entity reference: Guanine nucleotide-binding protein subunit alpha-14
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)
member entity reference: Guanine nucleotide-binding protein G(k) subunit alpha
member entity reference: G protein subunit alpha transducin 2
member entity reference: Gi alpha subunit
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 14
member entity reference: G protein alpha i subunit
member entity reference: G protein subunit alpha i1
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-2
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
member entity reference: EGL-30
member entity reference: G protein subunit alpha i3
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2b
member entity reference: Gnai3 protein
member entity reference: G protein alpha subunit Gi isoform X2
member entity reference: G protein subunit alpha i2

uniprot E2RPB0 378
type: UnificationXref
id: E2RPB0
db: uniprot

PARTICIPANT STOICHIOMETRY r79 597
type: Stoichiometry
physical entity: Complex (JAK Ligand/JAK receptor/ Grb2)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r79 596
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r79 595
type: Stoichiometry
physical entity: Complex (JAK Ligand/JAK receptor)
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ATP-_Caspase_9-RIGHT__Caspase_9-_ADP-_r51
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 692
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 691
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 690
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 693
left: ATP
left: Caspase-9
interaction type: STATE_TRANSITION
right: ADP
right: Caspase-9

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot A0A0G2K5T3 24
xref: PTHR10048:SF107
organism: Rattus norvegicus

PKB s122 a245 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.12
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot Q9Y243 92
type: UnificationXref
id: Q9Y243
db: uniprot

Complex (JAK Ligand/JAK receptor)
type: Complex
component stoichiometry: JAK receptor s73 sa65 STOICHIOMETRY ID COMPLEX
component stoichiometry: JAK Ligand s71 sa64 STOICHIOMETRY ID COMPLEX
component: JAK Ligand
component: JAK receptor
feature: COMPLEX BINDING FEATURE s191 a400 478
feature: ACTIVE 59
feature: COMPLEX BINDING FEATURE s191 a400 480
cellular location: cytoplasm

uniprot Q14642 370
type: UnificationXref
id: Q14642
db: uniprot

Nitric oxide synthase, endothelial
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot P70313 411
organism: Mus musculus

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P04897 326
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r75 616
type: Stoichiometry
physical entity: Complex (ITK ligand/Int Tyr Kin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r75 615
type: Stoichiometry
physical entity: ITK ligand
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r75 614
type: Stoichiometry
physical entity: Int Tyr Kin
stoichiometric coefficient: 1.0

IR s35 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IR
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P04899 327
organism: Homo sapiens

uniprot D4A3T0 134
type: UnificationXref
id: D4A3T0
db: uniprot

uniprot P01120 118
type: UnificationXref
id: P01120
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7GEK1 81
xref: PTHR24356:SF190
organism: Monodelphis domestica

GTP s217 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot A5D7R9 108
type: UnificationXref
id: A5D7R9
db: uniprot

GPCR ligand s61 sa55 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GPCR ligand
stoichiometric coefficient: 1.0

p110 s59 sa54 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p110
stoichiometric coefficient: 1.0

TRANSPORT
type: RelationshipTypeVocabulary

uniprot P17343 197
type: UnificationXref
id: P17343
db: uniprot

PTHR12305:SF81
type: RelationshipXref
id: PTHR12305:SF81
db: PANTHER Family
relationship type: By Homology

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 163

uniprot P30557 399
type: UnificationXref
id: P30557
db: uniprot

Phosphoinositide-3-kinase regulatory subunit 5
type: ProteinReference
xref: PTHR15593:SF2
xref: uniprot E2RLD1 395
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P17343 197
xref: PTHR19850:SF25
organism: Caenorhabditis elegans

uniprot H2Q7G4 286
type: UnificationXref
id: H2Q7G4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI_3,4,5_P3-RIGHT__PI_4,5_P2-_Pi-_r8
controller: PTEN

ncbitaxon 9031 31
type: UnificationXref
id: 9031
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r86 672
type: Stoichiometry
physical entity: JAK receptor
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r86 673
type: Stoichiometry
physical entity: JAK Ligand
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r86 674
type: Stoichiometry
physical entity: Complex (JAK Ligand/JAK receptor)
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot F6THW2 308
organism: Xenopus tropicalis

eco ECO:0000353 102
type: UnificationXref
id: ECO:0000353
db: eco

uniprot P23726 388
type: UnificationXref
id: P23726
db: uniprot

Gbetagamma s64 sa58 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbetagamma
stoichiometric coefficient: 1.0

IR
type: Protein
entity reference: IR
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa31 459
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Int Tyr Kin s8 a8 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.51
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY r40 629
type: Stoichiometry
physical entity: Complex (Gbetagamma/p101)
stoichiometric coefficient: 1.0

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

GNAI2 protein
type: ProteinReference
xref: uniprot A7MBH9 298
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r40 628
type: Stoichiometry
physical entity: p101
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r40 627
type: Stoichiometry
physical entity: Gbetagamma
stoichiometric coefficient: 1.0

uniprot E9FUX0 173
type: UnificationXref
id: E9FUX0
db: uniprot

uniprot P32871 46
type: UnificationXref
id: P32871
db: uniprot

IRS s32 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IRS
stoichiometric coefficient: 1.0

IR ligand s28 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IR ligand
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTP-_Complex__GDP_Ras_-RIGHT__Complex__Ras_GTP_-_GDP-_r35
controller: SOS

Int Tyr Kin s8 a8 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.81
comment: MODIFICATION_RESIDUE_NAME=

Protein ras-1
type: ProteinReference
xref: uniprot P22126 124
xref: PTHR24070:SF17
organism: Neurospora crassa

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 13

Ras
type: Protein
entity reference: Ras
feature: COMPLEX PARTICIPANT BINDING FEATURE s216 sa9 537
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r4 598
type: Stoichiometry
physical entity: p85
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 599
type: Stoichiometry
physical entity: p110
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 170
xref: PTHR19850:SF28
organism: Gallus gallus

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot O15530 43
organism: Homo sapiens

p101
type: Protein
entity reference: p101
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot G3V7R4 285
type: UnificationXref
id: G3V7R4
db: uniprot

uniprot Q62245 149
type: UnificationXref
id: Q62245
db: uniprot

uniprot D3ZBQ1 278
type: UnificationXref
id: D3ZBQ1
db: uniprot

STATE_TRANSITION_LEFT__PI_3,4,5_P3-RIGHT__PI_3,4_P2-_Pi-_r9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 567
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 566
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 565
left: PI(3,4,5)P3
interaction type: STATE_TRANSITION
right: Pi
right: PI(3,4)P2

uniprot F6ZIZ9 180
type: UnificationXref
id: F6ZIZ9
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7G3I5 39
xref: PTHR10048:SF107
organism: Monodelphis domestica

STATE_TRANSITION_LEFT__p110-RIGHT__P110ACT-_r16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 589
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 590
left: p110
interaction type: STATE_TRANSITION
right: P110ACT

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 186
xref: PTHR19850:SF28
organism: Monodelphis domestica

14-3-3 protein zeta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot Q5ZKC9 428
organism: Gallus gallus

Tyrosine-protein kinase receptor
type: ProteinReference
xref: PTHR24416:SF535
xref: uniprot F1MV64 152
organism: Bos taurus

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P08752 328
organism: Mus musculus

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot P08754 330
organism: Homo sapiens

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot P08753 329
organism: Rattus norvegicus

uniprot P23443 267
type: UnificationXref
id: P23443
db: uniprot

Protein CBR-LET-60
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot A8X0X5 109
organism: Caenorhabditis briggsae

uniprot Q9YH60 104
type: UnificationXref
id: Q9YH60
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot E1BBJ7 364
organism: Bos taurus

JAK
type: Protein
entity reference: JAK
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

JAK receptor
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s75 sa67 489
feature: JAK receptor s75 sa67 rs2
feature: JAK receptor s75 sa67 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Complex (ITK ligand/Int Tyr Kin/ Grb2)
type: Complex
component stoichiometry: ITK ligand s40 sa40 STOICHIOMETRY ID COMPLEX
component stoichiometry: Grb2 s42 sa42 STOICHIOMETRY ID COMPLEX
component stoichiometry: Int Tyr Kin s41 sa41 STOICHIOMETRY ID COMPLEX
component: Int Tyr Kin
component: ITK ligand
component: Grb2
feature: COMPLEX BINDING FEATURE s165 a339 526
feature: COMPLEX BINDING FEATURE s165 a339 522
feature: COMPLEX BINDING FEATURE s165 a339 524
cellular location: cytoplasm

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 233
xref: PTHR19850:SF28
organism: Homo sapiens

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: uniprot P38408 338
xref: PTHR10218:SF213
organism: Bos taurus

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot P38409 339
xref: PTHR10218:SF328
organism: Bos taurus

uniprot D4A433 279
type: UnificationXref
id: D4A433
db: uniprot

STATE_TRANSITION_LEFT__ATP-_Complex__PI_3,4,5_P3_PKB_-RIGHT__Complex__PI_3,4,5_P3_PKB_-_ADP-_r48
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 594
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 593
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 592
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 591
left: ATP
left: Complex (PI(3,4,5)P3/PKB)
interaction type: STATE_TRANSITION
right: Complex (PI(3,4,5)P3/PKB)
right: ADP

Forkhead box O4
type: ProteinReference
xref: uniprot E2RTA1 281
organism: Canis lupus familiaris

uniprot F7G3J2 186
type: UnificationXref
id: F7G3J2
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: uniprot Q92569 393
xref: PTHR10155:SF2
organism: Homo sapiens

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P38400 337
organism: Canis lupus familiaris

GADD45
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 203

uniprot Q5I080 349
type: UnificationXref
id: Q5I080
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q1NH21 69
xref: PTHR24356:SF176
organism: Bos taurus

STATE_TRANSITION_LEFT__ATP-_GSK3-RIGHT__GSK3-_ADP-_r50
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 699
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 701
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 698
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 700
left: GSK3
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: GSK3

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7GAP5 40
organism: Ornithorhynchus anatinus

Gbeta5
type: ProteinReference
xref: uniprot Q9W3J1 234
xref: PTHR19850:SF36
organism: Drosophila melanogaster

uniprot A0A2I3SIY1 375
type: UnificationXref
id: A0A2I3SIY1
db: uniprot

STATE_TRANSITION_LEFT__p110-RIGHT__P110ACT-_r36
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 644
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 643
left: p110
interaction type: STATE_TRANSITION
right: P110ACT

uniprot F6S3S1 406
type: UnificationXref
id: F6S3S1
db: uniprot

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot P29992 335
xref: PTHR10218:SF328
organism: Homo sapiens

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot F1P4J0 259
organism: Gallus gallus

FOXO s26 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FOXO
stoichiometric coefficient: 1.0

Ribosomal protein S6 kinase beta-2
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot Q9UBS0 271
organism: Homo sapiens

uniprot Q7Q6D4 231
type: UnificationXref
id: Q7Q6D4
db: uniprot

GPCR
type: Protein
entity reference: GPCR
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa15 451
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Danio rerio
type: BioSource
xref: ncbitaxon 7955 65

G protein subunit alpha q
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot K6ZCJ5 323
organism: Pan troglodytes

ncbitaxon 9615 11
type: UnificationXref
id: 9615
db: ncbitaxon

PI(3,4)P2
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Nitric oxide synthase, endothelial
type: ProteinReference
xref: uniprot Q9TUX8 414
xref: PTHR19384:SF66
organism: Canis lupus familiaris

p85
type: Protein
entity reference: p85
feature: COMPLEX PARTICIPANT BINDING FEATURE s58 sa53 435
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

PARTICIPANT STOICHIOMETRY r66 655
type: Stoichiometry
physical entity: Complex (IR ligand/IR/ IRS)
stoichiometric coefficient: 1.0

uniprot A8XPY6 60
type: UnificationXref
id: A8XPY6
db: uniprot

Complex (GPCR ligand/GPCR/ Galpha/Gbetagamma)
type: Complex
component stoichiometry: GPCR ligand s61 sa55 STOICHIOMETRY ID COMPLEX
component stoichiometry: GPCR s62 sa56 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbetagamma s64 sa58 STOICHIOMETRY ID COMPLEX
component stoichiometry: Galpha s213 sa57 STOICHIOMETRY ID COMPLEX
component: GPCR
component: GPCR ligand
component: Gbetagamma
component: Galpha
feature: COMPLEX BINDING FEATURE s183 a370 534
feature: COMPLEX BINDING FEATURE s183 a370 530
feature: COMPLEX BINDING FEATURE s183 a370 532
feature: COMPLEX BINDING FEATURE s183 a370 528
cellular location: cytoplasm

PARTICIPANT STOICHIOMETRY r66 654
type: Stoichiometry
physical entity: IRS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r66 653
type: Stoichiometry
physical entity: Complex (IR ligand/IR)
stoichiometric coefficient: 1.0

uniprot F7CXD0 182
type: UnificationXref
id: F7CXD0
db: uniprot

uniprot K6ZCJ5 323
type: UnificationXref
id: K6ZCJ5
db: uniprot

PTHR10454:SF157
type: RelationshipXref
id: PTHR10454:SF157
db: PANTHER Family
relationship type: By Homology

uniprot F6Y841 34
type: UnificationXref
id: F6Y841
db: uniprot

uniprot P04696 325
type: UnificationXref
id: P04696
db: uniprot

p110
type: Protein
entity reference: p110
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7EP57 382
type: UnificationXref
id: F7EP57
db: uniprot

uniprot F0ZB76 110
type: UnificationXref
id: F0ZB76
db: uniprot

uniprot Q6P549 372
type: UnificationXref
id: Q6P549
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6XP81 80
xref: PTHR24356:SF171
organism: Xenopus tropicalis

ITK ligand s43 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ITK ligand
stoichiometric coefficient: 1.0

uniprot A0A2I3RH39 374
type: UnificationXref
id: A0A2I3RH39
db: uniprot

PARTICIPANT STOICHIOMETRY r16 590
type: Stoichiometry
physical entity: P110ACT
stoichiometric coefficient: 1.0

uniprot Q5RKP9 350
type: UnificationXref
id: Q5RKP9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot F7FRT9 421
organism: Monodelphis domestica

Grb2
type: ProteinReference
xref: P01178
standard name: Growth factor receptor-bound protein 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Grb2 Synonym: Growth-factor-receptor-bound protein 2 Accession: P01178
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.Grb2
member entity reference: Growth factor receptor-bound protein 2
member entity reference: Growth factor receptor-bound protein 2a
member entity reference: Sex muscle abnormal protein 5
member entity reference: Protein CBR-SEM-5

PI(3,4,5)P3
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa22 465
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR11551:SF6
type: RelationshipXref
id: PTHR11551:SF6
db: PANTHER Family
relationship type: By Homology

uniprot P26450 390
type: UnificationXref
id: P26450
db: uniprot

uniprot P35570 253
type: UnificationXref
id: P35570
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 22

Nitric oxide synthase, inducible
type: ProteinReference
xref: uniprot Q06518 412
xref: PTHR19384:SF56
organism: Rattus norvegicus

Gbetagamma
type: Protein
entity reference: Gbetagamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa18 541
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot E2RH85 377
type: UnificationXref
id: E2RH85
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

INHIBITION
type: RelationshipTypeVocabulary

uniprot P21278 333
type: UnificationXref
id: P21278
db: uniprot

PTHR10411:SF3
type: RelationshipXref
id: PTHR10411:SF3
db: PANTHER Family
relationship type: By Homology

uniprot F7EFF6 420
type: UnificationXref
id: F7EFF6
db: uniprot

uniprot Q9JHK1 277
type: UnificationXref
id: Q9JHK1
db: uniprot

PDK1 ACT
type: ProteinReference
xref: P01190
standard name: 3-phosphoinositide-dependent protein kinase 1, active
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.PDK1 ACT
comment: ENTITY_REFERENCE_NOTES=
member entity reference: 3-phosphoinositide-dependent protein kinase 1
member entity reference: Uncharacterized protein
member entity reference: 3-phosphoinositide dependent protein kinase 1

Protein CBR-SEM-5
type: ProteinReference
xref: uniprot A8XPY6 60
xref: PTHR46037:SF1
organism: Caenorhabditis briggsae

uniprot F1PBL1 417
type: UnificationXref
id: F1PBL1
db: uniprot

uniprot F6RCU6 79
type: UnificationXref
id: F6RCU6
db: uniprot

GPCR
type: ProteinReference
xref: P01204
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.RECEPTOR.GPCR
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Prostaglandin E2 receptor EP3 subtype
member entity reference: Prostaglandin E2 receptor EP1 subtype

PTHR10048:SF33
type: RelationshipXref
id: PTHR10048:SF33
db: PANTHER Family
relationship type: By Homology

uniprot F1MYJ4 73
type: UnificationXref
id: F1MYJ4
db: uniprot

PARTICIPANT STOICHIOMETRY r45 607
type: Stoichiometry
physical entity: Complex (PI(3,4,5)P3/PDK1)
stoichiometric coefficient: 1.0

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
type: ProteinReference
xref: uniprot G5EE01 240
xref: PTHR12305:SF81
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r45 608
type: Stoichiometry
physical entity: Complex (PI(3,4,5)P3/PDK1 ACT)
stoichiometric coefficient: 1.0

14 3 3 s27 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 14-3-3
stoichiometric coefficient: 1.0

uniprot P08647 122
type: UnificationXref
id: P08647
db: uniprot

Caspase-9
type: ProteinReference
xref: PTHR10454:SF157
xref: uniprot Q8C3Q9 276
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RH85 377
xref: PTHR10155:SF1
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r52 689
type: Stoichiometry
physical entity: Bad
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r52 687
type: Stoichiometry
physical entity: Bad
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r52 688
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF200
xref: uniprot G3X7B5 82
organism: Bos taurus

uniprot Q503B6 129
type: UnificationXref
id: Q503B6
db: uniprot

PARTICIPANT STOICHIOMETRY r52 686
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot E2R9H7 280
type: UnificationXref
id: E2R9H7
db: uniprot

ncbitaxon 6238 61
type: UnificationXref
id: 6238
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r16 589
type: Stoichiometry
physical entity: p110
stoichiometric coefficient: 1.0

uniprot F7BWW9 142
type: UnificationXref
id: F7BWW9
db: uniprot

uniprot Q61017 226
type: UnificationXref
id: Q61017
db: uniprot

uniprot F7GEK1 81
type: UnificationXref
id: F7GEK1
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 111

-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
type: ProteinReference
xref: uniprot Q503B6 129
xref: PTHR24070:SF423
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r82 694
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PI(3,4,5)P3
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa26 447
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r82 696
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r82 695
type: Stoichiometry
physical entity: Complex (JAK Ligand/JAK receptor)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r82 697
type: Stoichiometry
physical entity: Complex (JAK Ligand/JAK receptor)
stoichiometric coefficient: 1.0

PTHR10048:SF14
type: RelationshipXref
id: PTHR10048:SF14
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot F7BS95 419
organism: Monodelphis domestica

STATE_TRANSITION_LEFT__ATP-_Bad-RIGHT__ADP-_Bad-_r52
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 686
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 688
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 687
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 689
left: ATP
left: Bad
interaction type: STATE_TRANSITION
right: ADP
right: Bad

p85 s82 sa75 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p85
stoichiometric coefficient: 1.0

cytoplasm
type: CellularLocationVocabulary
xref: GO GO:0005737 3

PTHR10614:SF13
type: RelationshipXref
id: PTHR10614:SF13
db: PANTHER Family
relationship type: By Homology

PTHR10614:SF11
type: RelationshipXref
id: PTHR10614:SF11
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3T9Y4 68
type: UnificationXref
id: A0A2I3T9Y4
db: uniprot

uniprot P29992 335
type: UnificationXref
id: P29992
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P16520 196
xref: PTHR19850:SF31
organism: Homo sapiens

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s76 sa68 491
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7FRT9 421
type: UnificationXref
id: F7FRT9
db: uniprot

uniprot F1N7C3 136
type: UnificationXref
id: F1N7C3
db: uniprot

uniprot A7EDU2 162
type: UnificationXref
id: A7EDU2
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: uniprot P23726 388
xref: PTHR10155:SF1
organism: Bos taurus

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P23727 389
organism: Bos taurus

Bad s134 a273 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

Complex (GPCR/Galpha/ Gbetagamma)
type: Complex
component stoichiometry: Gbetagamma s12 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: Galpha s11 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: GPCR s10 sa15 STOICHIOMETRY ID COMPLEX
component: Galpha
component: GPCR
component: Gbetagamma
feature: COMPLEX BINDING FEATURE s109 a227 454
feature: COMPLEX BINDING FEATURE s109 a227 450
feature: COMPLEX BINDING FEATURE s109 a227 452
cellular location: cytoplasm

PARTICIPANT STOICHIOMETRY r72 630
type: Stoichiometry
physical entity: Complex (ITK ligand/Int Tyr Kin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r72 631
type: Stoichiometry
physical entity: Complex (p85/p110)
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Gbetagamma-_p101-RIGHT__Complex__Gbetagamma_p101_-_r40
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 628
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 629
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 627
left: Gbetagamma
left: p101
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Gbetagamma/p101)

PARTICIPANT STOICHIOMETRY r72 632
type: Stoichiometry
physical entity: Complex (ITK ligand/Int Tyr Kin/ p85/p110)
stoichiometric coefficient: 1.0

uniprot O60674 16
type: UnificationXref
id: O60674
db: uniprot

Gi alpha subunit
type: ProteinReference
xref: uniprot C3XY80 302
organism: Branchiostoma floridae

uniprot Q5F3U4 53
type: UnificationXref
id: Q5F3U4
db: uniprot

uniprot P62881 214
type: UnificationXref
id: P62881
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6RCU6 79
xref: PTHR24356:SF171
organism: Macaca mulatta

uniprot P01111 115
type: UnificationXref
id: P01111
db: uniprot

uniprot P29355 62
type: UnificationXref
id: P29355
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot F7FXA9 185
organism: Macaca mulatta

STATE_TRANSITION_LEFT__ATP-_NOS-RIGHT__NOS-_ADP-_r53
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 682
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 681
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 679
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 680
left: NOS
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: NOS

uniprot F6URW3 140
type: UnificationXref
id: F6URW3
db: uniprot

JAK
type: ProteinReference
xref: P01176
comment: ENTITY_REFERENCE_NOTES= Long Name: JAK Synonym: JAK1,JAK2,JAK3,Janus kinase Accession: P01176
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.JAK
member entity reference: Tyrosine-protein kinase JAK2
member entity reference: Tyrosine-protein kinase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p110-RIGHT__P110ACT-_r36
controller: Complex (Ras/GTP)

uniprot F6QE96 76
type: UnificationXref
id: F6QE96
db: uniprot

uniprot E2RJX4 71
type: UnificationXref
id: E2RJX4
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P42336 47
xref: PTHR10048:SF107
organism: Homo sapiens

uniprot Q63788 392
type: UnificationXref
id: Q63788
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P42338 49
xref: PTHR10048:SF33
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42337 48
organism: Mus musculus

uniprot H2QDK7 265
type: UnificationXref
id: H2QDK7
db: uniprot

uniprot Q60823 89
type: UnificationXref
id: Q60823
db: uniprot

G1/S-specific cyclin-D2
type: DnaReference
xref: PTHR10177:SF66
organism: Homo sapiens

G1/S-specific cyclin-D1
type: DnaReference
xref: PTHR10177:SF67
organism: Homo sapiens

uniprot P55211 275
type: UnificationXref
id: P55211
db: uniprot

uniprot H2R8U9 143
type: UnificationXref
id: H2R8U9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot A0A1D5Q071 360
organism: Macaca mulatta

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F1P859 137
organism: Canis lupus familiaris

PTHR10218:SF213
type: RelationshipXref
id: PTHR10218:SF213
db: PANTHER Family
relationship type: By Homology

Gbetagamma
type: Protein
entity reference: Gbetagamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa17 455
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q5RKN6 64
type: UnificationXref
id: Q5RKN6
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot Q95ME4 133
xref: PTHR24070:SF189
organism: Monodelphis domestica

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot P49841 101
organism: Homo sapiens

uniprot Q7Q6D3 230
type: UnificationXref
id: Q7Q6D3
db: uniprot

IRS1 isoform 1
type: ProteinReference
xref: uniprot H2QJJ4 250
xref: PTHR10614:SF11
organism: Pan troglodytes

scl-1
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Probable type I inositol 1,4,5-trisphosphate 5-phosphatase
type: ProteinReference
xref: uniprot Q17848 371
organism: Caenorhabditis elegans

uniprot Q61012 225
type: UnificationXref
id: Q61012
db: uniprot

IR
type: Protein
entity reference: IR
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ITK ligand
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot E2R4I7 305
type: UnificationXref
id: E2R4I7
db: uniprot

uniprot P34995 401
type: UnificationXref
id: P34995
db: uniprot

Inositol polyphosphate-5-phosphatase A
type: ProteinReference
xref: uniprot F1MHB9 366
organism: Bos taurus

S6K s129 a257 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.88

SCP-Like extracellular protein
type: DnaReference
organism: Caenorhabditis elegans

Inositol polyphosphate-5-phosphatase A
type: ProteinReference
xref: uniprot D3ZZX1 363
organism: Rattus norvegicus

Int Tyr Kin
type: Protein
feature: Int Tyr Kin s50 sa46 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s50 sa46 517
feature: Int Tyr Kin s50 sa46 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot O14610 192
xref: PTHR13809:SF28
organism: Homo sapiens

JAK Ligand
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s80 sa73 499
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r51 693
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 692
type: Stoichiometry
physical entity: Caspase-9
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 691
type: Stoichiometry
physical entity: Caspase-9
stoichiometric coefficient: 1.0

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot F6XW91 418
organism: Ornithorhynchus anatinus

uniprot Q9Y1J3 55
type: UnificationXref
id: Q9Y1J3
db: uniprot

uniprot F6W0P2 312
type: UnificationXref
id: F6W0P2
db: uniprot

uniprot A0A2I3SYV7 4
type: UnificationXref
id: A0A2I3SYV7
db: uniprot

uniprot F7ECA6 315
type: UnificationXref
id: F7ECA6
db: uniprot

GADD45A isoform 1
type: DnaReference
xref: PTHR10411:SF3
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r51 690
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot F6Y3N2 179
type: UnificationXref
id: F6Y3N2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 195
xref: PTHR19850:SF27
organism: Bos taurus

IR ligand s34 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IR ligand
stoichiometric coefficient: 1.0

uniprot P38400 337
type: UnificationXref
id: P38400
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF36
xref: uniprot F7H6T7 187
organism: Macaca mulatta

ncbitaxon 8364 33
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot E2RLD1 395
type: UnificationXref
id: E2RLD1
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F6QUW1 139
organism: Monodelphis domestica

uniprot P54311 206
type: UnificationXref
id: P54311
db: uniprot

AGAP007643-PA
type: ProteinReference
xref: uniprot A0NBC2 415
xref: PTHR18860:SF106
organism: Anopheles gambiae

PARTICIPANT STOICHIOMETRY r69 640
type: Stoichiometry
physical entity: Complex (IR ligand/IR/ IRS)
stoichiometric coefficient: 1.0

PTHR45807:SF1
type: RelationshipXref
id: PTHR45807:SF1
db: PANTHER Family
relationship type: By Homology

uniprot P70597 403
type: UnificationXref
id: P70597
db: uniprot

PARTICIPANT STOICHIOMETRY r69 642
type: Stoichiometry
physical entity: Complex (IR ligand/IR/ IRS/p85/ p110)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r69 641
type: Stoichiometry
physical entity: Complex (p85/p110)
stoichiometric coefficient: 1.0

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot Q9Y243 92
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF26
xref: uniprot H2QUX9 190
organism: Pan troglodytes

Forkhead box protein O3
type: ProteinReference
xref: PTHR45767:SF4
xref: uniprot O43524 289
organism: Homo sapiens

uniprot F1MYE0 249
type: UnificationXref
id: F1MYE0
db: uniprot

uniprot F6VTR8 396
type: UnificationXref
id: F6VTR8
db: uniprot

uniprot F6UMX8 283
type: UnificationXref
id: F6UMX8
db: uniprot

PIK3R1 isoform 1
type: ProteinReference
xref: uniprot A0A2I3SIY1 375
xref: PTHR10155:SF3
organism: Pan troglodytes

p85
type: Protein
entity reference: p85
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

JAK Ligand s80 sa73 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JAK Ligand
stoichiometric coefficient: 1.0

uniprot Q17848 371
type: UnificationXref
id: Q17848
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7FDA0 38
organism: Monodelphis domestica

uniprot C3XY80 302
type: UnificationXref
id: C3XY80
db: uniprot

PARTICIPANT STOICHIOMETRY r33 657
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

FOXO
type: Protein
entity reference: FOXO
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa28 461
feature: FOXO s26 sa28 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r33 656
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

ncbitaxon 9598 5
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot Q5BH99 219
type: UnificationXref
id: Q5BH99
db: uniprot

JAK receptor s75 sa67 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.58
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

AGAP005911-PA
type: ProteinReference
xref: PTHR19850:SF25
xref: uniprot Q7Q6D4 231
organism: Anopheles gambiae

AGAP005913-PA
type: ProteinReference
xref: PTHR19850:SF25
xref: uniprot Q7Q6D2 228
organism: Anopheles gambiae

AGAP005912-PA
type: ProteinReference
xref: uniprot Q7Q6D3 230
xref: PTHR19850:SF25
organism: Anopheles gambiae

uniprot A8X0X5 109
type: UnificationXref
id: A8X0X5
db: uniprot

uniprot H2R3A6 191
type: UnificationXref
id: H2R3A6
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot K7CZM1 145
organism: Pan troglodytes

Pi
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR24351:SF171
type: RelationshipXref
id: PTHR24351:SF171
db: PANTHER Family
relationship type: By Homology

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 36

PTHR13809:SF28
type: RelationshipXref
id: PTHR13809:SF28
db: PANTHER Family
relationship type: By Homology

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot P23443 267
organism: Homo sapiens

uniprot D3ZLD6 168
type: UnificationXref
id: D3ZLD6
db: uniprot

PTHR13809:SF26
type: RelationshipXref
id: PTHR13809:SF26
db: PANTHER Family
relationship type: By Homology

p101 s14 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p101
stoichiometric coefficient: 1.0

ncbitaxon 6669 174
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot F7AQR3 314
type: UnificationXref
id: F7AQR3
db: uniprot

uniprot Q9TUX8 414
type: UnificationXref
id: Q9TUX8
db: uniprot

IRS
type: Protein
entity reference: IRS
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa34 477
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

p85 s37 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p85
stoichiometric coefficient: 1.0

ncbitaxon 7739 167
type: UnificationXref
id: 7739
db: ncbitaxon

Inositol polyphosphate phosphatase like 1
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot F1PNY0 367
organism: Canis lupus familiaris

Insulin-like growth factor binding protein-1
type: DnaReference
organism: Danio rerio

SHIP
type: Protein
entity reference: SHIP
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Nitric oxide synthase
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot A0A3Q1LSD1 405
organism: Bos taurus

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 11

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NGS8 159
xref: PTHR19850:SF31
organism: Bos taurus

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 189
xref: PTHR19850:SF28
organism: Pan troglodytes

GADD45
type: DnaRegionReference
member entity reference: Growth arrest and DNA damage-inducible protein GADD45 alpha
member entity reference: GADD45A isoform 1
member entity reference: Uncharacterized protein
xref: G01544
comment: ENTITY_REFERENCE_NOTES= Long Name: GADD45 Synonym: Synonym not specified Accession: G01544
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.GENE.GENE.GADD45

PARTICIPANT STOICHIOMETRY r17 582
type: Stoichiometry
physical entity: PI(3,4,5)P3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r17 583
type: Stoichiometry
physical entity: PI(3,4)P2
stoichiometric coefficient: 1.0

SCP-Like extracellular protein
type: DnaReference
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r17 584
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

PTEN
type: ProteinReference
xref: P01189
standard name: phospatase and tensin homologue
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.PTEN
comment: ENTITY_REFERENCE_NOTES= Long Name: PTEN Synonym: DAF-18,MMAC,TEP1,mutated in multiple advanced cancers,phosphatase and tensin homolog deleted on chromosome ten,tumour growth factor-beta-regulated and epithelial cell enriched phosphatase Accession: P01189
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
member entity reference: IP16020p
member entity reference: Uncharacterized protein

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F1MAI3 135
xref: PTHR23113:SF150
organism: Rattus norvegicus

Prostaglandin E2 receptor EP1 subtype
type: ProteinReference
xref: PTHR11866:SF3
xref: uniprot F1PIW8 398
organism: Canis lupus familiaris

P110ACT
type: ProteinReference
xref: P01177
standard name: Activated p110
comment: ENTITY_REFERENCE_NOTES= Long Name: Activated p110 Synonym: Activated Class IA PI3K catalytic subunit Accession: P01177
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.P110ACT
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
member entity reference: PI-3 kinase
member entity reference: 3-phosphoinositide dependent protein kinase 1
member entity reference: 3-phosphoinositide-dependent protein kinase 1
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

uniprot H9FVU5 42
type: UnificationXref
id: H9FVU5
db: uniprot

JAK receptor s75 sa67 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

IGFBP1
type: DnaRegionReference
member entity reference: Insulin-like growth factor-binding protein 1
member entity reference: Uncharacterized protein
member entity reference: Insulin-like growth factor binding protein-1
xref: G01543
comment: ENTITY_REFERENCE_NOTES= Long Name: IGFBP1 Synonym: Synonym not specified Accession: G01543
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.GENE.GENE.IGFBP1

uniprot Q9Z2A0 58
type: UnificationXref
id: Q9Z2A0
db: uniprot

uniprot Q7T3D3 352
type: UnificationXref
id: Q7T3D3
db: uniprot

PTHR11866:SF10
type: RelationshipXref
id: PTHR11866:SF10
db: PANTHER Family
relationship type: By Homology

uniprot P20353 332
type: UnificationXref
id: P20353
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot F7ECA6 315
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot P21278 333
organism: Mus musculus

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: uniprot P21279 334
xref: PTHR10218:SF316
organism: Mus musculus

uniprot Q02384 146
type: UnificationXref
id: Q02384
db: uniprot

PARTICIPANT STOICHIOMETRY r81 559
type: Stoichiometry
physical entity: Complex (p85/p110)
stoichiometric coefficient: 1.0

uniprot B8JLJ7 301
type: UnificationXref
id: B8JLJ7
db: uniprot

Complex (FOXO/14-3-3)
type: Complex
component stoichiometry: FOXO s26 sa28 STOICHIOMETRY ID COMPLEX
component stoichiometry: 14 3 3 s27 sa29 STOICHIOMETRY ID COMPLEX
component: 14-3-3
component: FOXO
feature: COMPLEX BINDING FEATURE s141 a285 462
feature: COMPLEX BINDING FEATURE s141 a285 460
cellular location: cytoplasm

Int Tyr Kin
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa44 513
feature: Int Tyr Kin s45 sa44 rs1
feature: Int Tyr Kin s45 sa44 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

p110
type: Protein
entity reference: p110
feature: COMPLEX PARTICIPANT BINDING FEATURE s59 sa54 437
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A0A3Q2U4X3 70
type: UnificationXref
id: A0A3Q2U4X3
db: uniprot

PARTICIPANT STOICHIOMETRY r81 558
type: Stoichiometry
physical entity: Complex (JAK Ligand/JAK receptor)
stoichiometric coefficient: 1.0

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot A0A2I3TNH3 235
organism: Pan troglodytes

Guanine nucleotide-binding protein (G protein), q polypeptide
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot Q28FH0 345
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r81 560
type: Stoichiometry
physical entity: Complex (JAK Ligand/JAK receptor/ p85/p110)
stoichiometric coefficient: 1.0

uniprot B8JIQ1 95
type: UnificationXref
id: B8JIQ1
db: uniprot

uniprot E9QAS7 365
type: UnificationXref
id: E9QAS7
db: uniprot

PI(3,4,5)P3
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PI 3,4,5 P3 s22 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PI(3,4,5)P3
stoichiometric coefficient: 1.0

uniprot O08908 386
type: UnificationXref
id: O08908
db: uniprot

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__Cyclin_d-RIGHT__Cycline_d-_re51
control type: INHIBITION
controller: FOXO

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 179
xref: PTHR19850:SF27
organism: Monodelphis domestica

Tyrosine-protein kinase JAK2
type: ProteinReference
xref: uniprot O60674 16
xref: PTHR45807:SF1
organism: Homo sapiens

uniprot E1BCP6 8
type: UnificationXref
id: E1BCP6
db: uniprot

uniprot Q7KMQ6 245
type: UnificationXref
id: Q7KMQ6
db: uniprot

uniprot P63101 423
type: UnificationXref
id: P63101
db: uniprot

uniprot Q62689 21
type: UnificationXref
id: Q62689
db: uniprot

uniprot P04897 326
type: UnificationXref
id: P04897
db: uniprot

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P47196 86
xref: PTHR24356:SF171
organism: Rattus norvegicus

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P47197 87
xref: PTHR24356:SF176
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: uniprot O95837 324
xref: PTHR10218:SF213
organism: Homo sapiens

FOXO3 isoform 1
type: ProteinReference
xref: PTHR45767:SF4
xref: uniprot H2R710 287
organism: Pan troglodytes

uniprot A0A2J8MGP0 394
type: UnificationXref
id: A0A2J8MGP0
db: uniprot

G1/S-specific cyclin-D1
type: DnaReference
xref: PTHR10177:SF67
organism: Mus musculus

G1/S-specific cyclin-D2
type: DnaReference
organism: Mus musculus

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P26308 198
xref: PTHR19850:SF25
organism: Drosophila melanogaster

Nitric oxide synthase
type: ProteinReference
xref: uniprot A0A1D5QGM1 404
xref: PTHR19384:SF66
organism: Macaca mulatta

uniprot G3X7B5 82
type: UnificationXref
id: G3X7B5
db: uniprot

JAK receptor
type: Protein
feature: JAK receptor s73 sa65 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s73 sa72 481
feature: JAK receptor s73 sa65 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

G1/S-specific cyclin-D2
type: DnaReference
xref: PTHR10177:SF66
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot F7CXD0 182
organism: Monodelphis domestica

G-protein beta subunit
type: ProteinReference
xref: uniprot Q5BH99 219
xref: PTHR19850:SF25
organism: Emericella nidulans

p110 s83 sa76 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p110
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r27 662
type: Stoichiometry
physical entity: p110
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r27 661
type: Stoichiometry
physical entity: p85
stoichiometric coefficient: 1.0

uniprot E7EXT6 72
type: UnificationXref
id: E7EXT6
db: uniprot

PTHR19384:SF56
type: RelationshipXref
id: PTHR19384:SF56
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r27 663
type: Stoichiometry
physical entity: Complex (p85/p110)
stoichiometric coefficient: 1.0

PTHR24070:SF189
type: RelationshipXref
id: PTHR24070:SF189
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(t) subunit alpha-2
type: ProteinReference
xref: uniprot P04696 325
organism: Bos taurus

HETERODIMER_ASSOCIATION_LEFT__Complex__JAK_Ligand_JAK_receptor_-_Complex__p85_p110_-RIGHT__Complex__JAK_Ligand_JAK_receptor__p85_p110_-_r81
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 560
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 558
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 559
left: Complex (p85/p110)
left: Complex (JAK Ligand/JAK receptor)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (JAK Ligand/JAK receptor/ p85/p110)

TRANSPORT_LEFT__FOXO-RIGHT__FOXO-_r56
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 665
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 664
left: FOXO
interaction type: TRANSPORT
right: FOXO

Cyclin d
type: DnaRegion
entity reference: Cyclin d
cellular location: nucleus
comment: SPECIES_TYPE=GENE

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 229

uniprot G5EE01 240
type: UnificationXref
id: G5EE01
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7F3S0 37
organism: Macaca mulatta

uniprot P11017 195
type: UnificationXref
id: P11017
db: uniprot

uniprot Q5KI86 222
type: UnificationXref
id: Q5KI86
db: uniprot

uniprot P38409 339
type: UnificationXref
id: P38409
db: uniprot

STATE_TRANSITION_LEFT__PI_3,4,5_P3-RIGHT__PI_3,4_P2-_Pi-_r17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 583
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 584
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 582
left: PI(3,4,5)P3
interaction type: STATE_TRANSITION
right: Pi
right: PI(3,4)P2

Nitric oxide synthase
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot H2QVM2 407
organism: Pan troglodytes

ncbitaxon 665079 163
type: UnificationXref
id: 665079
db: ncbitaxon

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 102

FOXO s138 a281 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.63
comment: MODIFICATION_RESIDUE_NAME=

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P27986 391
organism: Homo sapiens

uniprot A0A2I3TNH3 235
type: UnificationXref
id: A0A2I3TNH3
db: uniprot

STATE_TRANSITION_LEFT__ATP-_PI_4,5_P2-RIGHT__PI_3,4,5_P3-_ADP-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 576
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 575
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 574
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 577
left: ATP
left: PI(4,5)P2
interaction type: STATE_TRANSITION
right: ADP
right: PI(3,4,5)P3

PKB
type: Protein
entity reference: PKB
feature: PKB s122 a245 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PI_4,5_P2-RIGHT__PI_3,4,5_P3-_ADP-_r7
controller: Complex (ITK ligand/Int Tyr Kin/ p85/p110)

Son of sevenless homolog 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot H9FYU7 144
organism: Macaca mulatta

PTHR19384:SF66
type: RelationshipXref
id: PTHR19384:SF66
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
type: ProteinReference
xref: uniprot Q3ZCA7 346
organism: Bos taurus

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot Q62600 413
type: UnificationXref
id: Q62600
db: uniprot

uniprot A0A1D5QK27 273
type: UnificationXref
id: A0A1D5QK27
db: uniprot

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q9Z2A0 58
organism: Mus musculus

Caspase 9, isoform CRA_a
type: ProteinReference
xref: uniprot Q9JHK1 277
xref: PTHR10454:SF157
organism: Rattus norvegicus

Galpha
type: Protein
entity reference: Galpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s68 sa61 497
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Evidence 67
type: Evidence
evidence code: ISS
comment: Website http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot F6TPX7 260
organism: Ornithorhynchus anatinus

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot O55173 45
organism: Rattus norvegicus

uniprot P98177 290
type: UnificationXref
id: P98177
db: uniprot

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot Q6TJY3 269
organism: Bos taurus

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot D4AE24 255
organism: Rattus norvegicus

Complex (JAK Ligand/JAK receptor/ Grb2)
type: Complex
component stoichiometry: JAK receptor s75 sa67 STOICHIOMETRY ID COMPLEX
component stoichiometry: Grb2 s76 sa68 STOICHIOMETRY ID COMPLEX
component stoichiometry: JAK Ligand s74 sa66 STOICHIOMETRY ID COMPLEX
component: Grb2
component: JAK receptor
component: JAK Ligand
feature: COMPLEX BINDING FEATURE s192 a390 486
feature: COMPLEX BINDING FEATURE s192 a390 490
feature: COMPLEX BINDING FEATURE s192 a390 488
cellular location: cytoplasm

DISSOCIATION
type: InteractionVocabulary

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: uniprot A0A2I3SXI2 93
xref: PTHR24057:SF8
organism: Pan troglodytes

uniprot F1Q118 138
type: UnificationXref
id: F1Q118
db: uniprot

PI-3 kinase
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot P91634 51
organism: Drosophila melanogaster

uniprot B7Q3T6 164
type: UnificationXref
id: B7Q3T6
db: uniprot

uniprot P42336 47
type: UnificationXref
id: P42336
db: uniprot

GNB4 protein
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot A5PKD6 161
organism: Bos taurus

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 17

GDP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r73 623
type: Stoichiometry
physical entity: Complex (ITK ligand/Int Tyr Kin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r73 624
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FD32 316
organism: Macaca mulatta

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: uniprot O00459 385
xref: PTHR10155:SF1
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r73 625
type: Stoichiometry
physical entity: Complex (ITK ligand/Int Tyr Kin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r73 626
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot C3ZSF0 166
type: UnificationXref
id: C3ZSF0
db: uniprot

IGFBP1
type: DnaRegion
entity reference: IGFBP1
cellular location: nucleus
comment: SPECIES_TYPE=GENE

PTHR24351:SF48
type: RelationshipXref
id: PTHR24351:SF48
db: PANTHER Family
relationship type: By Homology

uniprot P01119 116
type: UnificationXref
id: P01119
db: uniprot

Complex (Gbetagamma/p101)
type: Complex
component stoichiometry: p101 s14 sa19 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbetagamma s13 sa18 STOICHIOMETRY ID COMPLEX
component: p101
component: Gbetagamma
feature: COMPLEX BINDING FEATURE s115 a234 542
feature: COMPLEX BINDING FEATURE s115 a234 540
feature: ACTIVE 59
cellular location: cytoplasm

uniprot Q6TJY3 269
type: UnificationXref
id: Q6TJY3
db: uniprot

JAK Ligand
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot O54857 242
type: UnificationXref
id: O54857
db: uniprot

Guanine nucleotide-binding protein (G protein), q polypeptide
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot B8JLJ7 301
organism: Danio rerio

p110 s3 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p110
stoichiometric coefficient: 1.0

Ras-like protein 1
type: ProteinReference
xref: uniprot P08647 122
organism: Schizosaccharomyces pombe

SOS
type: Protein
entity reference: SOS
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PDK1
type: Protein
entity reference: PDK1
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa21 509
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

TRANSCRIPTION
type: RelationshipTypeVocabulary

uniprot H9FYU7 144
type: UnificationXref
id: H9FYU7
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PI_4,5_P2-RIGHT__PI_3,4,5_P3-_ADP-_r7
controller: P110ACT

G protein subunit alpha i3
type: ProteinReference
xref: uniprot Q5I080 349
organism: Xenopus tropicalis

uniprot F1MAI3 135
type: UnificationXref
id: F1MAI3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI_3,4,5_P3-RIGHT__PI_3,4_P2-_Pi-_r17
controller: SHIP

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

PTHR11866:SF3
type: RelationshipXref
id: PTHR11866:SF3
db: PANTHER Family
relationship type: By Homology

Complex (ITK ligand/Int Tyr Kin/ p85/p110)
type: Complex
component stoichiometry: ITK ligand s56 sa51 STOICHIOMETRY ID COMPLEX
component stoichiometry: p85 s58 sa53 STOICHIOMETRY ID COMPLEX
component stoichiometry: p110 s59 sa54 STOICHIOMETRY ID COMPLEX
component stoichiometry: Int Tyr Kin s57 sa52 STOICHIOMETRY ID COMPLEX
component: p85
component: Int Tyr Kin
component: ITK ligand
component: p110
feature: COMPLEX BINDING FEATURE s175 a357 436
feature: COMPLEX BINDING FEATURE s175 a357 430
feature: COMPLEX BINDING FEATURE s175 a357 434
feature: COMPLEX BINDING FEATURE s175 a357 432
cellular location: cytoplasm

HRas proto-oncogene, GTPase a
type: ProteinReference
xref: uniprot F1QNG4 113
xref: PTHR24070:SF423
organism: Danio rerio

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 44

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 63

uniprot P35569 252
type: UnificationXref
id: P35569
db: uniprot

JAK Ligand s77 sa69 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JAK Ligand
stoichiometric coefficient: 1.0

uniprot A0A2I3SXI2 93
type: UnificationXref
id: A0A2I3SXI2
db: uniprot

uniprot F1P859 137
type: UnificationXref
id: F1P859
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F1MYM3 27
organism: Bos taurus

Galpha s68 sa61 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Galpha
stoichiometric coefficient: 1.0

PTHR10177:SF66
type: RelationshipXref
id: PTHR10177:SF66
db: PANTHER Family
relationship type: By Homology

ncbitaxon 214684 223
type: UnificationXref
id: 214684
db: ncbitaxon

PTHR10177:SF67
type: RelationshipXref
id: PTHR10177:SF67
db: PANTHER Family
relationship type: By Homology

uniprot F6R8N3 78
type: UnificationXref
id: F6R8N3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI_3,4,5_P3-RIGHT__PI_4,5_P2-_Pi-_r19
controller: PTEN

uniprot P31749 83
type: UnificationXref
id: P31749
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI_3,4,5_P3-RIGHT__PI_3,4_P2-_Pi-_r9
controller: SHIP

ACTIVE 59
type: EntityFeature
comment: Active state

GTP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q62120 18
type: UnificationXref
id: Q62120
db: uniprot

ncbitaxon 13616 13
type: UnificationXref
id: 13616
db: ncbitaxon

Ras
type: Protein
entity reference: Ras
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa11 439
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 180
xref: PTHR19850:SF28
organism: Macaca mulatta

SOS
type: Protein
entity reference: SOS
feature: ACTIVE 59
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Insulin-like receptor
type: ProteinReference
xref: PTHR24416:SF525
xref: uniprot P09208 154
organism: Drosophila melanogaster

FOXO s26 sa28 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.63
comment: MODIFICATION_RESIDUE_NAME=

G1/S-specific cyclin-D1
type: DnaReference
xref: PTHR10177:SF67
organism: Macaca mulatta

p85
type: Protein
entity reference: p85
feature: COMPLEX PARTICIPANT BINDING FEATURE s82 sa75 503
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphoinositide 3-kinase regulatory subunit 5
type: ProteinReference
xref: PTHR15593:SF2
xref: uniprot Q8WYR1 397
organism: Homo sapiens

p110 s39 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p110
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r55 669
type: Stoichiometry
physical entity: 14-3-3
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__PI_3,4,5_P3-_PKB-RIGHT__Complex__PI_3,4,5_P3_PKB_-_r47
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 601
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 602
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 603
left: PI(3,4,5)P3
left: PKB
interaction type: HETERODIMER_ASSOCIATION
right: Complex (PI(3,4,5)P3/PKB)

uniprot P47197 87
type: UnificationXref
id: P47197
db: uniprot

G protein subunit beta 3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot H2R3A6 191
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r50 701
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r50 700
type: Stoichiometry
physical entity: GSK3
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: uniprot F7A472 313
organism: Xenopus tropicalis

ncbitaxon 6239 56
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot H9ENT4 266
type: UnificationXref
id: H9ENT4
db: uniprot

ncbitaxon 284812 123
type: UnificationXref
id: 284812
db: ncbitaxon

G protein subunit alpha transducin 2
type: ProteinReference
xref: uniprot E2R4I7 305
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r76 609
type: Stoichiometry
physical entity: GPCR ligand
stoichiometric coefficient: 1.0

uniprot A8XQR9 416
type: UnificationXref
id: A8XQR9
db: uniprot

STATE_TRANSITION_LEFT__ATP-_PI_4,5_P2-RIGHT__PI_3,4,5_P3-_ADP-_r18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 581
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 580
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 579
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 578
left: ATP
left: PI(4,5)P2
interaction type: STATE_TRANSITION
right: ADP
right: PI(3,4,5)P3

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1MYJ4 73
xref: PTHR24356:SF190
organism: Bos taurus

HETERODIMER_ASSOCIATION_LEFT__IR_ligand-_IR-RIGHT__Complex__IR_ligand_IR_-_r65
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 660
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 659
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 658
left: IR ligand
left: IR
interaction type: HETERODIMER_ASSOCIATION
right: Complex (IR ligand/IR)

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot O54857 242
organism: Rattus norvegicus

Gbetagamma s12 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbetagamma
stoichiometric coefficient: 1.0

uniprot A0A2I3TUD1 158
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

Candida albicans
type: BioSource
xref: ncbitaxon 237561 131

uniprot H2QNS5 189
type: UnificationXref
id: H2QNS5
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot E2RJX4 71
organism: Canis lupus familiaris

SCP-Like extracellular protein
type: DnaReference
organism: Caenorhabditis elegans

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__scl_1-RIGHT__scl_1-_re53
control type: ACTIVATION
controller: FOXO

uniprot F1PNY0 367
type: UnificationXref
id: F1PNY0
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot H2QNG6 41
organism: Pan troglodytes

SCP-Like extracellular protein
type: DnaReference
organism: Caenorhabditis elegans

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F1Q4F8 75
organism: Canis lupus familiaris

SCP-Like extracellular protein
type: DnaReference
organism: Caenorhabditis elegans

uniprot P29477 410
type: UnificationXref
id: P29477
db: uniprot

SCP-Like extracellular protein
type: DnaReference
organism: Caenorhabditis elegans

SCP-Like extracellular protein
type: DnaReference
organism: Caenorhabditis elegans

S6K
type: Protein
entity reference: S6K
feature: S6K s129 a257 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 50

uniprot A0A3Q1NH21 69
type: UnificationXref
id: A0A3Q1NH21
db: uniprot

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q9Y1J3 55
organism: Caenorhabditis elegans

uniprot P62879 212
type: UnificationXref
id: P62879
db: uniprot

p85
type: ProteinReference
xref: P01202
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.p85
comment: ENTITY_REFERENCE_NOTES= Long Name: p85 Synonym: Class IA PI3K regulatory subunit Accession: P01202
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit beta
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit gamma
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
member entity reference: Phosphoinositide-3-kinase regulatory subunit 2
member entity reference: Phosphoinositide-3-kinase regulatory subunit 1
member entity reference: Phosphoinositide-3-kinase regulatory subunit 3
member entity reference: PIK3R1 isoform 1

uniprot Q9HAV0 233
type: UnificationXref
id: Q9HAV0
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot Q9WVR3 373
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P36408 201
xref: PTHR19850:SF25
organism: Dictyostelium discoideum

IR ligand
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa35 545
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7G1U7 318
type: UnificationXref
id: F7G1U7
db: uniprot

uniprot P63104 426
type: UnificationXref
id: P63104
db: uniprot

Prostaglandin E2 receptor EP1 subtype
type: ProteinReference
xref: uniprot P35375 402
xref: PTHR11866:SF3
organism: Mus musculus

GPCR ligand
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s61 sa55 529
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__JAK_receptor-_JAK_Ligand-RIGHT__Complex__JAK_Ligand_JAK_receptor_-_r86
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 674
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 672
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 673
left: JAK Ligand
left: JAK receptor
interaction type: HETERODIMER_ASSOCIATION
right: Complex (JAK Ligand/JAK receptor)

uniprot Q8WSS1 354
type: UnificationXref
id: Q8WSS1
db: uniprot

uniprot F1N4K5 282
type: UnificationXref
id: F1N4K5
db: uniprot

Forkhead box O4
type: ProteinReference
xref: uniprot K7CRH3 288
organism: Pan troglodytes

uniprot F5HH30 176
type: UnificationXref
id: F5HH30
db: uniprot

uniprot F7G3I5 39
type: UnificationXref
id: F7G3I5
db: uniprot

uniprot A0A3Q1NGS8 159
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF176
type: RelationshipXref
id: PTHR24356:SF176
db: PANTHER Family
relationship type: By Homology

Forkhead box protein O1
type: ProteinReference
xref: uniprot Q12778 291
xref: PTHR45767:SF1
organism: Homo sapiens

Phosphoinositide-3-kinase regulatory subunit 1
type: ProteinReference
xref: uniprot F1Q2Q9 379
xref: PTHR10155:SF3
organism: Canis lupus familiaris

uniprot F1QNG4 113
type: UnificationXref
id: F1QNG4
db: uniprot

ncbitaxon 9913 9
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot F1Q3M8 29
type: UnificationXref
id: F1Q3M8
db: uniprot

uniprot P18266 100
type: UnificationXref
id: P18266
db: uniprot

uniprot P08752 328
type: UnificationXref
id: P08752
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A2I3T9Y4 68
xref: PTHR24356:SF190
organism: Pan troglodytes

uniprot P22981 126
type: UnificationXref
id: P22981
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: PTHR19850:SF27
xref: uniprot P62879 212
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 211
xref: PTHR19850:SF29
organism: Mus musculus

STATE_TRANSITION_LEFT__PI_3,4,5_P3-RIGHT__PI_4,5_P2-_Pi-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 570
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 569
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 568
left: PI(3,4,5)P3
interaction type: STATE_TRANSITION
right: Pi
right: PI(4,5)P2

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot O08586 241
xref: PTHR12305:SF81
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 209
xref: PTHR19850:SF29
organism: Canis lupus familiaris

uniprot P62880 213
type: UnificationXref
id: P62880
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 210
xref: PTHR19850:SF29
organism: Homo sapiens

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot P62881 214
xref: PTHR19850:SF36
organism: Mus musculus

Caspase-9
type: Protein
entity reference: Caspase-9
feature: Caspase 9 s133 a270 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: PTHR19850:SF27
xref: uniprot P62880 213
organism: Mus musculus

PTHR24356:SF190
type: RelationshipXref
id: PTHR24356:SF190
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Complex__Ras_GDP_-_GTP-RIGHT__Complex__Ras_GTP_-_GDP-_r34
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 651
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 652
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 650
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 649
left: GTP
left: Complex (Ras/GDP)
interaction type: STATE_TRANSITION
right: Complex (Ras/GTP)
right: GDP

Type I inositol 1,4,5-trisphosphate 5-phosphatase
type: ProteinReference
xref: uniprot Q14642 370
organism: Homo sapiens

uniprot Q5F3B5 348
type: UnificationXref
id: Q5F3B5
db: uniprot

uniprot P63097 344
type: UnificationXref
id: P63097
db: uniprot

uniprot F7BS95 419
type: UnificationXref
id: F7BS95
db: uniprot

Gnai3 protein
type: ProteinReference
xref: uniprot A9JTC8 299
organism: Danio rerio

uniprot P31751 85
type: UnificationXref
id: P31751
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot P62871 208
organism: Bos taurus

PDK1
type: Protein
entity reference: PDK1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 7227 52
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot F7FDA0 38
type: UnificationXref
id: F7FDA0
db: uniprot

uniprot P21279 334
type: UnificationXref
id: P21279
db: uniprot

IR
type: Protein
entity reference: IR
feature: COMPLEX PARTICIPANT BINDING FEATURE s35 sa36 547
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

GPCR ligand s65 sa59 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GPCR ligand
stoichiometric coefficient: 1.0

FOXO
type: Protein
entity reference: FOXO
feature: FOXO s201 a286 rs1
feature: ACTIVE 59
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

IR ligand
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa30 457
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7G1K7 317
type: UnificationXref
id: F7G1K7
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 5

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot F6UK84 261
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot F1MDX9 237
organism: Bos taurus

uniprot Q20636 218
type: UnificationXref
id: Q20636
db: uniprot

uniprot H2Q4C6 368
type: UnificationXref
id: H2Q4C6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p110-RIGHT__P110ACT-_r16
controller: Complex (Ras/GTP)

uniprot F6VXG1 32
type: UnificationXref
id: F6VXG1
db: uniprot

uniprot Q95ME4 133
type: UnificationXref
id: Q95ME4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF25
xref: uniprot C3ZSF0 166
organism: Branchiostoma floridae

JAK receptor
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s78 sa70 485
feature: JAK receptor s78 sa70 rs1
feature: JAK receptor s78 sa70 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Forkhead box protein O3
type: ProteinReference
xref: PTHR45767:SF4
xref: uniprot Q9WVH4 294
organism: Mus musculus

uniprot F1Q2Y3 28
type: UnificationXref
id: F1Q2Y3
db: uniprot

Forkhead box protein O4
type: ProteinReference
xref: uniprot Q9WVH3 293
organism: Mus musculus

p110
type: Protein
entity reference: p110
feature: COMPLEX PARTICIPANT BINDING FEATURE s39 sa39 553
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot E1BA29 304
type: UnificationXref
id: E1BA29
db: uniprot

uniprot F1Q2Q9 379
type: UnificationXref
id: F1Q2Q9
db: uniprot

Prostaglandin E2 receptor EP1 subtype
type: ProteinReference
xref: uniprot P70597 403
xref: PTHR11866:SF3
organism: Rattus norvegicus

Nitric oxide synthase, endothelial
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot P29474 409
organism: Homo sapiens

P110ACT
type: Protein
entity reference: P110ACT
feature: ACTIVE 59
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Nitric oxide synthase, inducible
type: ProteinReference
xref: uniprot P29477 410
xref: PTHR19384:SF56
organism: Mus musculus

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa12 441
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9544 15
type: UnificationXref
id: 9544
db: ncbitaxon

GO GO:0005634 2
type: UnificationXref
id: GO:0005634
db: GO

GSK3
type: ProteinReference
xref: P01181
standard name: Glycogen synthase kinase 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.GSK3
comment: ENTITY_REFERENCE_NOTES= Long Name: GSK3 Synonym: Glycogen synthase kinase 3 Accession: P01181
member entity reference: Uncharacterized protein
member entity reference: Si:dkeyp-80c12.7
member entity reference: Glycogen synthase kinase-3 beta
member entity reference: Glycogen synthase kinase 3 beta
member entity reference: Glycogen synthase kinase-3 beta isoform 1
member entity reference: Glycogen synthase kinase 3

uniprot O00459 385
type: UnificationXref
id: O00459
db: uniprot

Forkhead box O1
type: ProteinReference
xref: uniprot E2R9H7 280
organism: Canis lupus familiaris

Growth arrest and DNA damage-inducible protein GADD45 alpha
type: DnaReference
xref: PTHR10411:SF3
organism: Homo sapiens

uniprot Q9WVR3 373
type: UnificationXref
id: Q9WVR3
db: uniprot

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 177
xref: PTHR19850:SF29
organism: Ornithorhynchus anatinus

JAK receptor s73 sa65 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JAK receptor
stoichiometric coefficient: 1.0

uniprot F6XP81 80
type: UnificationXref
id: F6XP81
db: uniprot

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q04970 128
organism: Rattus norvegicus

PTHR24356:SF163
type: RelationshipXref
id: PTHR24356:SF163
db: PANTHER Family
relationship type: By Homology

TRANSCRIPTION_LEFT__IGFBP1-RIGHT__IGFBP1-_re52
type: TemplateReaction
product: IGFBP1
xref: TRANSCRIPTION
participant: IGFBP1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PI3 kinase pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__p110-RIGHT__P110ACT-_r36
pathway component: STATE_TRANSITION_LEFT__PI_3,4,5_P3-RIGHT__PI_3,4_P2-_Pi-_r17
pathway component: STATE_TRANSITION_LEFT__Complex__ITK_ligand_Int_Tyr_Kin_-_ATP-RIGHT__Complex__ITK_ligand_Int_Tyr_Kin_-_ADP-_r73
pathway component: HETERODIMER_ASSOCIATION_LEFT__p85-_p110-RIGHT__Complex__p85_p110_-_r27
pathway component: HETERODIMER_ASSOCIATION_LEFT__p85-_p110-RIGHT__Complex__p85_p110_-_r23
pathway component: HETERODIMER_ASSOCIATION_LEFT__IR_ligand-_IR-RIGHT__Complex__IR_ligand_IR_-_r65
pathway component: HETERODIMER_ASSOCIATION_LEFT__p85-_p110-RIGHT__Complex__p85_p110_-_r4
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__JAK_Ligand_JAK_receptor_-_Grb2-RIGHT__Complex__JAK_Ligand_JAK_receptor__Grb2_-_r79
pathway component: HETERODIMER_ASSOCIATION_LEFT__JAK_receptor-_JAK_Ligand-RIGHT__Complex__JAK_Ligand_JAK_receptor_-_r86
pathway component: HETERODIMER_ASSOCIATION_LEFT__PI_3,4,5_P3-_PDK1-RIGHT__Complex__PI_3,4,5_P3_PDK1_-_r42
pathway component: STATE_TRANSITION_LEFT__PI_3,4,5_P3-RIGHT__PI_3,4_P2-_Pi-_r9
pathway component: STATE_TRANSITION_LEFT__PI_3,4,5_P3-RIGHT__PI_4,5_P2-_Pi-_r19
pathway component: TRANSCRIPTION_LEFT__IGFBP1-RIGHT__IGFBP1-_re52
pathway component: STATE_TRANSITION_LEFT__GTP-_Complex__GDP_Ras_-RIGHT__Complex__Ras_GTP_-_GDP-_r35
pathway component: HETERODIMER_ASSOCIATION_LEFT__14_3_3-_FOXO-RIGHT__Complex__FOXO_14_3_3_-_r55
pathway component: STATE_TRANSITION_LEFT__FOXO-_ATP-RIGHT__ADP-_FOXO-_r54
pathway component: STATE_TRANSITION_LEFT__ATP-_Complex__JAK_receptor_JAK_Ligand_-RIGHT__ADP-_Complex__JAK_Ligand_JAK_receptor_-_r80
pathway component: STATE_TRANSITION_LEFT__ATP-_Bad-RIGHT__ADP-_Bad-_r52
pathway component: DISSOCIATION_LEFT__Complex__GPCR_ligand_GPCR__Galpha_Gbetagamma_-RIGHT__Gbetagamma-_Complex__GPCR_ligand_GPCR__Galpha_-_r78
pathway component: STATE_TRANSITION_LEFT__ATP-_Complex__PI_3,4,5_P3_PKB_-RIGHT__Complex__PI_3,4,5_P3_PKB_-_ADP-_r48
pathway component: STATE_TRANSITION_LEFT__ATP-_PI_4,5_P2-RIGHT__PI_3,4,5_P3-_ADP-_r18
pathway component: HETERODIMER_ASSOCIATION_LEFT__Int_Tyr_Kin-_ITK_ligand-RIGHT__Complex__ITK_ligand_Int_Tyr_Kin_-_r74
pathway component: STATE_TRANSITION_LEFT__Complex__Ras_GDP_-_GTP-RIGHT__Complex__Ras_GTP_-_GDP-_r34
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__IR_ligand_IR__IRS_-_Complex__p85_p110_-RIGHT__Complex__IR_ligand_IR__IRS_p85__p110_-_r69
pathway component: HETERODIMER_ASSOCIATION_LEFT__Int_Tyr_Kin-_ITK_ligand-RIGHT__Complex__ITK_ligand_Int_Tyr_Kin_-_r75
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__IR_ligand_IR_-_IRS-RIGHT__Complex__IR_ligand_IR__IRS_-_r66
pathway component: TRANSCRIPTION_LEFT__scl_1-RIGHT__scl_1-_re53
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__ITK_ligand_Int_Tyr_Kin_-_Complex__p85_p110_-RIGHT__Complex__ITK_ligand_Int_Tyr_Kin__p85_p110_-_r72
pathway component: TRANSCRIPTION_LEFT__Cyclin_d-RIGHT__Cycline_d-_re51
pathway component: STATE_TRANSITION_LEFT__ATP-_GSK3-RIGHT__GSK3-_ADP-_r50
pathway component: STATE_TRANSITION_LEFT__PI_3,4,5_P3-RIGHT__PI_4,5_P2-_Pi-_r8
pathway component: TRANSCRIPTION_LEFT__GADD45-RIGHT__GADD45-_re50
pathway component: STATE_TRANSITION_LEFT__SOS-RIGHT__SOS-_r12
pathway component: HETERODIMER_ASSOCIATION_LEFT__GPCR_ligand-_Complex__GPCR_Galpha__Gbetagamma_-RIGHT__Complex__GPCR_ligand_GPCR__Galpha_Gbetagamma_-_r76
pathway component: STATE_TRANSITION_LEFT__ATP-_NOS-RIGHT__NOS-_ADP-_r53
pathway component: STATE_TRANSITION_LEFT__p110-RIGHT__P110ACT-_r16
pathway component: HETERODIMER_ASSOCIATION_LEFT__Gbetagamma-_p101-RIGHT__Complex__Gbetagamma_p101_-_r40
pathway component: STATE_TRANSITION_LEFT__ATP-_Caspase_9-RIGHT__Caspase_9-_ADP-_r51
pathway component: STATE_TRANSITION_LEFT__ATP-_Complex__JAK_Ligand_JAK_receptor_-RIGHT__ADP-_Complex__JAK_Ligand_JAK_receptor_-_r82
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__ITK_ligand_Int_Tyr_Kin_-_Grb2-RIGHT__Complex__ITK_ligand_Int_Tyr_Kin__Grb2_-_r70
pathway component: TRANSPORT_LEFT__FOXO-RIGHT__FOXO-_r56
pathway component: STATE_TRANSITION_LEFT__Complex__ITK_ligand_Int_Tyr_Kin_-_ATP-RIGHT__Complex__ITK_ligand_Int_Tyr_Kin_-_ADP-_r71
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__JAK_Ligand_JAK_receptor_-_Complex__p85_p110_-RIGHT__Complex__JAK_Ligand_JAK_receptor__p85_p110_-_r81
pathway component: STATE_TRANSITION_LEFT__SOS-RIGHT__SOS-_r33
pathway component: HETERODIMER_ASSOCIATION_LEFT__PI_3,4,5_P3-_PKB-RIGHT__Complex__PI_3,4,5_P3_PKB_-_r47
pathway component: STATE_TRANSITION_LEFT__ATP-_PI_4,5_P2-RIGHT__PI_3,4,5_P3-_ADP-_r7
pathway component: STATE_TRANSITION_LEFT__Complex__PI_3,4,5_P3_PDK1_-RIGHT__Complex__PI_3,4,5_P3_PDK1_ACT_-_r45
pathway component: STATE_TRANSITION_LEFT__ATP-_S6K-RIGHT__S6K-_ADP-_r49
pathway component: HETERODIMER_ASSOCIATION_LEFT__JAK_receptor-_JAK_Ligand-RIGHT__Complex__JAK_receptor_JAK_Ligand_-_r84
xref: PANTHER Pathway P00048 1
comment: MODEL_NOTES=Panther Pathway: P00048 Phosphoinositide 3-kinase (PI3K) catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, which is involved in several crucial biological processes, including cell survival, regulation of gene expression and cell metabolism, and cytoskeletal rearrangements. The PI3K pathway is also implicated in several human diseases, including diabetes and cancer. Medline=12040186 Medline=12062096 Medline=12646949 Medline=12829733 Medline=12871670 PMID: 12040186 PMID: 12062096 PMID: 12646949 PMID: 12829733 PMID: 12871670

Ras-like protein rasD
type: ProteinReference
xref: PTHR24070:SF418
xref: uniprot P03967 119
organism: Dictyostelium discoideum

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot O14775 193
xref: PTHR19850:SF36
organism: Homo sapiens

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot Q07890 148
xref: PTHR23113:SF150
organism: Homo sapiens

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot P60484 244
organism: Homo sapiens

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot P60483 243
organism: Canis lupus familiaris

Int Tyr Kin
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s57 sa52 433
feature: Int Tyr Kin s57 sa52 rs2
feature: Int Tyr Kin s57 sa52 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RIM7 307
organism: Monodelphis domestica

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Caspase_9-RIGHT__Caspase_9-_ADP-_r51
controller: Complex (PI(3,4,5)P3/PKB)

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot E1BLQ5 256
organism: Bos taurus

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 171
xref: PTHR19850:SF28
organism: Canis lupus familiaris

Phosphoinositide-3-kinase regulatory subunit 3
type: ProteinReference
xref: uniprot A0A2I3RH39 374
xref: PTHR10155:SF2
organism: Pan troglodytes

Complex (ITK ligand/Int Tyr Kin)
type: Complex
component stoichiometry: ITK ligand s43 sa43 STOICHIOMETRY ID COMPLEX
component stoichiometry: Int Tyr Kin s45 sa44 STOICHIOMETRY ID COMPLEX
component: Int Tyr Kin
component: ITK ligand
feature: COMPLEX BINDING FEATURE s166 a340 512
feature: ACTIVE 59
feature: COMPLEX BINDING FEATURE s166 a340 510
cellular location: cytoplasm

JAK Ligand s70 sa63 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JAK Ligand
stoichiometric coefficient: 1.0

uniprot O15357 369
type: UnificationXref
id: O15357
db: uniprot

uniprot Q5ZKC9 428
type: UnificationXref
id: Q5ZKC9
db: uniprot

uniprot F7A472 313
type: UnificationXref
id: F7A472
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 15

ncbitaxon 7668 106
type: UnificationXref
id: 7668
db: ncbitaxon

G protein subunit alpha 14
type: ProteinReference
xref: uniprot F7G1U7 318
xref: PTHR10218:SF213
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r65 659
type: Stoichiometry
physical entity: IR
stoichiometric coefficient: 1.0

IP16020p
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot Q7KMQ6 245
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r65 658
type: Stoichiometry
physical entity: IR ligand
stoichiometric coefficient: 1.0

Prostaglandin E2 receptor EP3 subtype
type: ProteinReference
xref: PTHR11866:SF10
xref: uniprot P30557 399
organism: Mus musculus

G protein subunit alpha transducin 2
type: ProteinReference
xref: uniprot D4AA42 303
organism: Rattus norvegicus

JAK receptor s78 sa70 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JAK receptor
stoichiometric coefficient: 1.0

Forkhead box protein O1
type: ProteinReference
xref: PTHR45767:SF1
xref: uniprot Q9R1E0 292
organism: Mus musculus

JAK receptor s75 sa67 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JAK receptor
stoichiometric coefficient: 1.0

ncbitaxon 6945 165
type: UnificationXref
id: 6945
db: ncbitaxon

uniprot P15208 156
type: UnificationXref
id: P15208
db: uniprot

GSK3 s130 a267 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.75

3-phosphoinositide dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot F1Q2Y3 28
organism: Canis lupus familiaris

PTHR24070:SF418
type: RelationshipXref
id: PTHR24070:SF418
db: PANTHER Family
relationship type: By Homology

PI(4,5)P2
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q06518 412
type: UnificationXref
id: Q06518
db: uniprot

uniprot P29829 200
type: UnificationXref
id: P29829
db: uniprot

uniprot P38408 338
type: UnificationXref
id: P38408
db: uniprot

Int Tyr Kin s45 sa44 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.81
comment: MODIFICATION_RESIDUE_NAME=

eco ECO:0000304 63
type: UnificationXref
id: ECO:0000304
db: eco

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot Q9DC51 356
organism: Mus musculus

JAK Ligand s71 sa64 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JAK Ligand
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r47 603
type: Stoichiometry
physical entity: Complex (PI(3,4,5)P3/PKB)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r47 602
type: Stoichiometry
physical entity: PKB
stoichiometric coefficient: 1.0

Forkhead box O4
type: ProteinReference
xref: uniprot D4A433 279
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r47 601
type: Stoichiometry
physical entity: PI(3,4,5)P3
stoichiometric coefficient: 1.0

uniprot P02698 194
type: UnificationXref
id: P02698
db: uniprot

Gbetagamma
type: Protein
entity reference: Gbetagamma
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P49177 202
type: UnificationXref
id: P49177
db: uniprot

ITK ligand s56 sa51 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ITK ligand
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__JAK_receptor-_JAK_Ligand-RIGHT__Complex__JAK_receptor_JAK_Ligand_-_r84
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r84 685
participant stoichiometry: PARTICIPANT STOICHIOMETRY r84 684
participant stoichiometry: PARTICIPANT STOICHIOMETRY r84 683
left: JAK Ligand
left: JAK receptor
interaction type: HETERODIMER_ASSOCIATION
right: Complex (JAK receptor/JAK Ligand)

Uncharacterized protein
type: ProteinReference
xref: PTHR45767:SF4
xref: uniprot F1N4K5 282
organism: Bos taurus

uniprot O14775 193
type: UnificationXref
id: O14775
db: uniprot

PTHR24070:SF420
type: RelationshipXref
id: PTHR24070:SF420
db: PANTHER Family
relationship type: By Homology

Inositol polyphosphate-5-phosphatase A
type: ProteinReference
xref: uniprot E9QAS7 365
organism: Mus musculus

PTHR24070:SF423
type: RelationshipXref
id: PTHR24070:SF423
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot F7EFF6 420
organism: Macaca mulatta

uniprot O46404 387
type: UnificationXref
id: O46404
db: uniprot

JAK Ligand
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s70 sa63 471
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Int Tyr Kin s45 sa44 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.51
comment: MODIFICATION_RESIDUE_NAME=

uniprot A0A3Q2TVV5 94
type: UnificationXref
id: A0A3Q2TVV5
db: uniprot

P01179
type: UnificationXref
id: P01179
db: PANTHER Pathway Component

P01177
type: UnificationXref
id: P01177
db: PANTHER Pathway Component

P01178
type: UnificationXref
id: P01178
db: PANTHER Pathway Component

Complex (PI(3,4,5)P3/PDK1)
type: Complex
component stoichiometry: PI 3,4,5 P3 s15 sa20 STOICHIOMETRY ID COMPLEX
component stoichiometry: PDK1 s16 sa21 STOICHIOMETRY ID COMPLEX
component: PI(3,4,5)P3
component: PDK1
feature: COMPLEX BINDING FEATURE s118 a237 508
feature: COMPLEX BINDING FEATURE s118 a237 506
cellular location: cytoplasm

P01176
type: UnificationXref
id: P01176
db: PANTHER Pathway Component

G protein alpha subunit Gi isoform X2
type: ProteinReference
xref: uniprot Q8WSS1 354
organism: Ciona intestinalis

uniprot H2QJJ4 250
type: UnificationXref
id: H2QJJ4
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__14_3_3-_FOXO-RIGHT__Complex__FOXO_14_3_3_-_r55
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 671
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 669
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 670
left: 14-3-3
left: FOXO
interaction type: HETERODIMER_ASSOCIATION
right: Complex (FOXO/14-3-3)

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot D4A3T0 134
organism: Rattus norvegicus

STATE_TRANSITION
type: RelationshipTypeVocabulary

ITK ligand
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s43 sa43 511
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7BTW0 262
type: UnificationXref
id: F7BTW0
db: uniprot

Insulin receptor
type: ProteinReference
xref: PTHR24416:SF535
xref: uniprot P15127 155
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PI_4,5_P2-RIGHT__PI_3,4,5_P3-_ADP-_r7
controller: Complex (IR ligand/IR/ IRS/p85/ p110)

uniprot F1A421 175
type: UnificationXref
id: F1A421
db: uniprot

ITK ligand s46 sa45 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ITK ligand
stoichiometric coefficient: 1.0

G protein subunit beta 5
type: ProteinReference
xref: PTHR19850:SF36
xref: uniprot H2Q9G5 188
organism: Pan troglodytes

P01197
type: UnificationXref
id: P01197
db: PANTHER Pathway Component

P01198
type: UnificationXref
id: P01198
db: PANTHER Pathway Component

P01196
type: UnificationXref
id: P01196
db: PANTHER Pathway Component

uniprot Q8UUX0 90
type: UnificationXref
id: Q8UUX0
db: uniprot

P01199
type: UnificationXref
id: P01199
db: PANTHER Pathway Component

P01190
type: UnificationXref
id: P01190
db: PANTHER Pathway Component

P01193
type: UnificationXref
id: P01193
db: PANTHER Pathway Component

P01194
type: UnificationXref
id: P01194
db: PANTHER Pathway Component

P01192
type: UnificationXref
id: P01192
db: PANTHER Pathway Component

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 61

Uncharacterized protein
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot Q5F3U4 53
organism: Gallus gallus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q8UUX0 90
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EP57 382
xref: PTHR10155:SF1
organism: Macaca mulatta

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 56

PARTICIPANT STOICHIOMETRY r65 660
type: Stoichiometry
physical entity: Complex (IR ligand/IR)
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: PTHR19850:SF30
xref: uniprot P29829 200
organism: Drosophila melanogaster

G protein subunit alpha i1
type: ProteinReference
xref: uniprot A0A2I3S4R3 296
organism: Pan troglodytes

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot Q8BTI9 54
organism: Mus musculus

uniprot F1PHV7 112
type: UnificationXref
id: F1PHV7
db: uniprot

P01185
type: UnificationXref
id: P01185
db: PANTHER Pathway Component

P01187
type: UnificationXref
id: P01187
db: PANTHER Pathway Component

P01188
type: UnificationXref
id: P01188
db: PANTHER Pathway Component

P01189
type: UnificationXref
id: P01189
db: PANTHER Pathway Component

Nitric oxide synthase
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot F6S3S1 406
organism: Monodelphis domestica

Son of sevenless homolog 1
type: ProteinReference
xref: uniprot Q07889 147
xref: PTHR23113:SF168
organism: Homo sapiens

GSK3
type: Protein
entity reference: GSK3
feature: GSK3 s130 a267 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

P01181
type: UnificationXref
id: P01181
db: PANTHER Pathway Component

P01182
type: UnificationXref
id: P01182
db: PANTHER Pathway Component

uniprot A7MBH9 298
type: UnificationXref
id: A7MBH9
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: uniprot O08908 386
xref: PTHR10155:SF1
organism: Mus musculus

G protein subunit alpha q
type: ProteinReference
xref: uniprot E1BA29 304
xref: PTHR10218:SF316
organism: Bos taurus

Ras
type: Protein
entity reference: Ras
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa4 521
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Galpha s11 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Galpha
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r50 699
type: Stoichiometry
physical entity: GSK3
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot A0A1D5QG31 295
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r50 698
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot D4AA42 303
type: UnificationXref
id: D4AA42
db: uniprot

PARTICIPANT STOICHIOMETRY r18 580
type: Stoichiometry
physical entity: PI(3,4,5)P3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r18 581
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PI(3,4,5)P3
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa24 443
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A2I3T7A8 25
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

PTHR18860:SF7
type: RelationshipXref
id: PTHR18860:SF7
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r49 588
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: uniprot Q63788 392
xref: PTHR10155:SF1
organism: Rattus norvegicus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P32871 46
xref: PTHR10048:SF107
organism: Bos taurus

uniprot F6TPX7 260
type: UnificationXref
id: F6TPX7
db: uniprot

PARTICIPANT STOICHIOMETRY r49 585
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 223

Int Tyr Kin s45 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Int Tyr Kin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r49 587
type: Stoichiometry
physical entity: S6K
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR45767:SF1
xref: uniprot F6ZVZ0 284
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r49 586
type: Stoichiometry
physical entity: S6K
stoichiometric coefficient: 1.0

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa42 527
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: uniprot E2RB53 96
xref: PTHR24057:SF8
organism: Canis lupus familiaris

uniprot A5PKD6 161
type: UnificationXref
id: A5PKD6
db: uniprot

Complex (GPCR ligand/GPCR/ Galpha)
type: Complex
component stoichiometry: Galpha s68 sa61 STOICHIOMETRY ID COMPLEX
component stoichiometry: GPCR s66 sa60 STOICHIOMETRY ID COMPLEX
component stoichiometry: GPCR ligand s65 sa59 STOICHIOMETRY ID COMPLEX
component: GPCR
component: Galpha
component: GPCR ligand
feature: COMPLEX BINDING FEATURE s185 a372 496
feature: COMPLEX BINDING FEATURE s185 a372 492
feature: COMPLEX BINDING FEATURE s185 a372 494
cellular location: cytoplasm

uniprot F6SW23 30
type: UnificationXref
id: F6SW23
db: uniprot

uniprot P16520 196
type: UnificationXref
id: P16520
db: uniprot

uniprot Q04970 128
type: UnificationXref
id: Q04970
db: uniprot

JAK receptor s69 sa62 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JAK receptor
stoichiometric coefficient: 1.0

IRS
type: ProteinReference
xref: P01193
standard name: Insulin Receptor Substrate
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.IRS
comment: ENTITY_REFERENCE_NOTES= Long Name: Insulin Receptor Substrate Synonym: IRS,chico,ist-1 Accession: P01193
member entity reference: Insulin receptor substrate 1
member entity reference: IRS1 isoform 1
member entity reference: Uncharacterized protein

uniprot F1PIW8 398
type: UnificationXref
id: F1PIW8
db: uniprot

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q60823 89
xref: PTHR24356:SF176
organism: Mus musculus

Int Tyr Kin s57 sa52 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Int Tyr Kin
stoichiometric coefficient: 1.0

PTHR23113:SF168
type: RelationshipXref
id: PTHR23113:SF168
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3TN41 26
type: UnificationXref
id: A0A2I3TN41
db: uniprot

uniprot P27986 391
type: UnificationXref
id: P27986
db: uniprot

G1/S-specific cyclin-D2
type: DnaReference
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r80 561
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

ncbitaxon 10116 22
type: UnificationXref
id: 10116
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r80 562
type: Stoichiometry
physical entity: Complex (JAK receptor/JAK Ligand)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r18 578
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot E2RHY4 172
type: UnificationXref
id: E2RHY4
db: uniprot

PARTICIPANT STOICHIOMETRY r18 579
type: Stoichiometry
physical entity: PI(4,5)P2
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_NOS-RIGHT__NOS-_ADP-_r53
controller: Complex (PI(3,4,5)P3/PKB)

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 167

uniprot P22126 124
type: UnificationXref
id: P22126
db: uniprot

uniprot F7BZL6 381
type: UnificationXref
id: F7BZL6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YCI3 141
xref: PTHR23113:SF150
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot P52287 205
organism: Rattus norvegicus

uniprot H2R710 287
type: UnificationXref
id: H2R710
db: uniprot

Glycogen synthase kinase-3 beta isoform 1
type: ProteinReference
xref: uniprot H9EPM1 99
xref: PTHR24057:SF8
organism: Macaca mulatta

uniprot F7GAP5 40
type: UnificationXref
id: F7GAP5
db: uniprot

ncbitaxon 227321 220
type: UnificationXref
id: 227321
db: ncbitaxon

Growth arrest and DNA damage-inducible protein GADD45 alpha
type: DnaReference
xref: PTHR10411:SF3
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r71 636
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot F7F3S0 37
type: UnificationXref
id: F7F3S0
db: uniprot

PARTICIPANT STOICHIOMETRY r71 635
type: Stoichiometry
physical entity: Complex (ITK ligand/Int Tyr Kin)
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Complex__IR_ligand_IR__IRS_-_Complex__p85_p110_-RIGHT__Complex__IR_ligand_IR__IRS_p85__p110_-_r69
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 640
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 642
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 641
left: Complex (p85/p110)
left: Complex (IR ligand/IR/ IRS)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (IR ligand/IR/ IRS/p85/ p110)

PARTICIPANT STOICHIOMETRY r71 634
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FOXO-_ATP-RIGHT__ADP-_FOXO-_r54
controller: Complex (PI(3,4,5)P3/PKB)

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PI_4,5_P2-RIGHT__PI_3,4,5_P3-_ADP-_r18
controller: P110ACT

PARTICIPANT STOICHIOMETRY r71 633
type: Stoichiometry
physical entity: Complex (ITK ligand/Int Tyr Kin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r84 683
type: Stoichiometry
physical entity: JAK receptor
stoichiometric coefficient: 1.0

S6K
type: ProteinReference
xref: P01194
standard name: ribosomal protein S6 kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.S6K
comment: ENTITY_REFERENCE_NOTES= Long Name: S6K Synonym: p70 S6 kinase Accession: P01194
member entity reference: Ribosomal protein S6 kinase beta-1
member entity reference: Ribosomal protein S6 kinase
member entity reference: Ribosomal protein S6 kinase beta-2
member entity reference: Non-specific serine/threonine protein kinase

PARTICIPANT STOICHIOMETRY r84 684
type: Stoichiometry
physical entity: JAK Ligand
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r84 685
type: Stoichiometry
physical entity: Complex (JAK receptor/JAK Ligand)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G1K7 317
xref: PTHR10218:SF316
organism: Monodelphis domestica

GDP s9 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot P63211 216
type: UnificationXref
id: P63211
db: uniprot

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 355

uniprot P31750 84
type: UnificationXref
id: P31750
db: uniprot

GADD45
type: DnaRegion
entity reference: GADD45
cellular location: nucleus
comment: SPECIES_TYPE=GENE

uniprot E2RMD8 258
type: UnificationXref
id: E2RMD8
db: uniprot

G protein subunit alpha transducin 2
type: ProteinReference
xref: uniprot F6W0P2 312
organism: Monodelphis domestica

uniprot Q8C3Q9 276
type: UnificationXref
id: Q8C3Q9
db: uniprot

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P08556 121
organism: Mus musculus

uniprot P79737 127
type: UnificationXref
id: P79737
db: uniprot

IR ligand
type: Protein
comment: SPECIES_TYPE=PROTEIN

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6QE96 76
xref: PTHR24356:SF176
organism: Macaca mulatta

TRANSCRIPTION
type: InteractionVocabulary

ATP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Phosphoinositide-3-kinase regulatory subunit 2
type: ProteinReference
xref: uniprot H2QFS6 384
xref: PTHR10155:SF1
organism: Pan troglodytes

JAK receptor s69 sa62 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PTHR45767:SF1
type: RelationshipXref
id: PTHR45767:SF1
db: PANTHER Family
relationship type: By Homology

Int Tyr Kin s50 sa46 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.81
comment: MODIFICATION_RESIDUE_NAME=

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot B2RSH2 300
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1PRG4 74
xref: PTHR24356:SF176
organism: Canis lupus familiaris

PTHR45767:SF4
type: RelationshipXref
id: PTHR45767:SF4
db: PANTHER Family
relationship type: By Homology

P01202
type: UnificationXref
id: P01202
db: PANTHER Pathway Component

NOS s136 a276 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.74

P01200
type: UnificationXref
id: P01200
db: PANTHER Pathway Component

Guanine nucleotide-binding protein G(K) subunit alpha
type: ProteinReference
xref: uniprot F6VL43 311
organism: Macaca mulatta

PANTHER Pathway P00048 1
type: UnificationXref
id: P00048
db: PANTHER Pathway

P01204
type: UnificationXref
id: P01204
db: PANTHER Pathway Component

P01203
type: UnificationXref
id: P01203
db: PANTHER Pathway Component

P01206
type: UnificationXref
id: P01206
db: PANTHER Pathway Component

P01205
type: UnificationXref
id: P01205
db: PANTHER Pathway Component

uniprot Q9XTN2 254
type: UnificationXref
id: Q9XTN2
db: uniprot

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot Q9WV60 103
organism: Mus musculus

G1/S-specific cyclin-D2
type: DnaReference
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: PTHR19850:SF25
xref: uniprot Q10282 217
organism: Schizosaccharomyces pombe

uniprot Q9WUA6 91
type: UnificationXref
id: Q9WUA6
db: uniprot

ITK ligand s40 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ITK ligand
stoichiometric coefficient: 1.0

SHIP
type: ProteinReference
xref: P01200
standard name: SH2 domain-containing inositol 5-phosphatase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.SHIP
comment: ENTITY_REFERENCE_NOTES= Long Name: SHIP Synonym: SH2-domain-containing inositol phosphatase Accession: P01200
member entity reference: Inositol polyphosphate phosphatase like 1
member entity reference: Type I inositol 1,4,5-trisphosphate 5-phosphatase
member entity reference: 5PtaseI, isoform F
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
member entity reference: Inositol polyphosphate-5-phosphatase A
member entity reference: Uncharacterized protein
member entity reference: INPPL1 isoform 1
member entity reference: Probable type I inositol 1,4,5-trisphosphate 5-phosphatase

HETERODIMER_ASSOCIATION_LEFT__p85-_p110-RIGHT__Complex__p85_p110_-_r4
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 598
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 599
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 600
left: p85
left: p110
interaction type: HETERODIMER_ASSOCIATION
right: Complex (p85/p110)

uniprot E1BW98 170
type: UnificationXref
id: E1BW98
db: uniprot

PARTICIPANT STOICHIOMETRY r80 563
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r80 564
type: Stoichiometry
physical entity: Complex (JAK Ligand/JAK receptor)
stoichiometric coefficient: 1.0

uniprot F6VKI4 310
type: UnificationXref
id: F6VKI4
db: uniprot

eco ECO:0000305 44
type: UnificationXref
id: ECO:0000305
db: eco

uniprot F6PGC8 177
type: UnificationXref
id: F6PGC8
db: uniprot

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: uniprot P18266 100
xref: PTHR24057:SF8
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r34 649
type: Stoichiometry
physical entity: Complex (Ras/GDP)
stoichiometric coefficient: 1.0

uniprot P29387 199
type: UnificationXref
id: P29387
db: uniprot

STATE_TRANSITION_LEFT__Complex__ITK_ligand_Int_Tyr_Kin_-_ATP-RIGHT__Complex__ITK_ligand_Int_Tyr_Kin_-_ADP-_r71
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 636
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 634
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 635
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 633
left: ATP
left: Complex (ITK ligand/Int Tyr Kin)
interaction type: STATE_TRANSITION
right: ADP
right: Complex (ITK ligand/Int Tyr Kin)

STATE_TRANSITION_LEFT__Complex__ITK_ligand_Int_Tyr_Kin_-_ATP-RIGHT__Complex__ITK_ligand_Int_Tyr_Kin_-_ADP-_r73
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 623
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 625
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 624
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 626
left: ATP
left: Complex (ITK ligand/Int Tyr Kin)
interaction type: STATE_TRANSITION
right: ADP
right: Complex (ITK ligand/Int Tyr Kin)

PARTICIPANT STOICHIOMETRY r74 617
type: Stoichiometry
physical entity: Int Tyr Kin
stoichiometric coefficient: 1.0

Int Tyr Kin s50 sa46 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.51
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY r74 618
type: Stoichiometry
physical entity: ITK ligand
stoichiometric coefficient: 1.0

CASP9 isoform 4
type: ProteinReference
xref: PTHR10454:SF157
xref: uniprot A0A2I3TJU8 274
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r74 619
type: Stoichiometry
physical entity: Complex (ITK ligand/Int Tyr Kin)
stoichiometric coefficient: 1.0

JAK receptor s69 sa62 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.58
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot A0A3Q3ACS4 376
organism: Gallus gallus

uniprot P62874 211
type: UnificationXref
id: P62874
db: uniprot

FOXO s201 a286 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.63
comment: MODIFICATION_RESIDUE_NAME=

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PI_4,5_P2-RIGHT__PI_3,4,5_P3-_ADP-_r18
controller: Complex (Gbetagamma/p101)

PARTICIPANT STOICHIOMETRY r54 678
type: Stoichiometry
physical entity: FOXO
stoichiometric coefficient: 1.0

G protein subunit beta 2
type: ProteinReference
xref: PTHR19850:SF27
xref: uniprot A0A2I3TUD1 158
organism: Pan troglodytes

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot O15357 369
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__GPCR_ligand-_Complex__GPCR_Galpha__Gbetagamma_-RIGHT__Complex__GPCR_ligand_GPCR__Galpha_Gbetagamma_-_r76
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 611
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 610
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 609
left: GPCR ligand
left: Complex (GPCR/Galpha/ Gbetagamma)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GPCR ligand/GPCR/ Galpha/Gbetagamma)

PARTICIPANT STOICHIOMETRY r54 676
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r54 677
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q7ZW82 353
type: UnificationXref
id: Q7ZW82
db: uniprot

PARTICIPANT STOICHIOMETRY r54 675
type: Stoichiometry
physical entity: FOXO
stoichiometric coefficient: 1.0

GPCR ligand
type: Protein
comment: SPECIES_TYPE=PROTEIN

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot F7CQS0 263
organism: Macaca mulatta

uniprot H2QVM2 407
type: UnificationXref
id: H2QVM2
db: uniprot

Grb2
type: Protein
entity reference: Grb2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Insulin receptor
type: ProteinReference
xref: uniprot P06213 153
xref: PTHR24416:SF535
organism: Homo sapiens

IRS
type: Protein
entity reference: IRS
feature: COMPLEX PARTICIPANT BINDING FEATURE s36 sa37 549
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F1N7C3 136
xref: PTHR23113:SF168
organism: Bos taurus

IDA
type: EvidenceCodeVocabulary

Complex (Ras/GTP)
type: Complex
component stoichiometry: Ras s216 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s217 sa10 STOICHIOMETRY ID COMPLEX
component: GTP
component: Ras
feature: COMPLEX BINDING FEATURE s215 a189 536
feature: COMPLEX BINDING FEATURE s215 a189 538
feature: ACTIVE 59
cellular location: cytoplasm

uniprot Q07890 148
type: UnificationXref
id: Q07890
db: uniprot

uniprot F6QP11 77
type: UnificationXref
id: F6QP11
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__PI_3,4,5_P3-_PDK1-RIGHT__Complex__PI_3,4,5_P3_PDK1_-_r42
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 621
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 622
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 620
left: PI(3,4,5)P3
left: PDK1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (PI(3,4,5)P3/PDK1)

uniprot P50146 340
type: UnificationXref
id: P50146
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Int_Tyr_Kin-_ITK_ligand-RIGHT__Complex__ITK_ligand_Int_Tyr_Kin_-_r75
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 616
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 615
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 614
left: Int Tyr Kin
left: ITK ligand
interaction type: HETERODIMER_ASSOCIATION
right: Complex (ITK ligand/Int Tyr Kin)

uniprot P35568 251
type: UnificationXref
id: P35568
db: uniprot

uniprot A0A2R8Q8S1 107
type: UnificationXref
id: A0A2R8Q8S1
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot P63097 344
organism: Bos taurus

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot P63096 343
organism: Homo sapiens

GO GO:0005737 3
type: UnificationXref
id: GO:0005737
db: GO

PARTICIPANT STOICHIOMETRY r34 651
type: Stoichiometry
physical entity: Complex (Ras/GTP)
stoichiometric coefficient: 1.0

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r34 650
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Int_Tyr_Kin-_ITK_ligand-RIGHT__Complex__ITK_ligand_Int_Tyr_Kin_-_r74
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 618
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 617
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 619
left: Int Tyr Kin
left: ITK ligand
interaction type: HETERODIMER_ASSOCIATION
right: Complex (ITK ligand/Int Tyr Kin)

uniprot F7EBE7 184
type: UnificationXref
id: F7EBE7
db: uniprot

PARTICIPANT STOICHIOMETRY r34 652
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot A0A2I3TRE1 361
type: UnificationXref
id: A0A2I3TRE1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SOS-RIGHT__SOS-_r33
controller: Complex (JAK Ligand/JAK receptor/ Grb2)

Son of sevenless homolog 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot Q62245 149
organism: Mus musculus

Nitric oxide synthase, inducible
type: ProteinReference
xref: uniprot O62699 408
organism: Canis lupus familiaris

V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot A0A2R8Q8S1 107
organism: Danio rerio

uniprot B7Z0Q1 362
type: UnificationXref
id: B7Z0Q1
db: uniprot

uniprot P91634 51
type: UnificationXref
id: P91634
db: uniprot

PTHR24070:SF17
type: RelationshipXref
id: PTHR24070:SF17
db: PANTHER Family
relationship type: By Homology

SCP-Like extracellular protein
type: DnaReference
organism: Caenorhabditis elegans

JAK Ligand s74 sa66 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JAK Ligand
stoichiometric coefficient: 1.0

Growth factor receptor-bound protein 2
type: ProteinReference
evidence: Evidence 67
xref: uniprot Q6PC73 66
xref: PTHR46037:SF4
organism: Danio rerio

GPCR s62 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GPCR
stoichiometric coefficient: 1.0

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa3 519
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

IR
type: ProteinReference
xref: P01187
standard name: Insulin Receptor
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.RECEPTOR.IR
comment: ENTITY_REFERENCE_NOTES= Long Name: Insulin Receptor Synonym: DAF-2,IGF-1R,IR,IRR,Insulin Growth Factor 1 Receptor,Insulin-receptor-like receptor Accession: P01187
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Insulin-like receptor
member entity reference: Tyrosine-protein kinase receptor
member entity reference: Insulin receptor

Insulin-like growth factor-binding protein 1
type: DnaReference
organism: Mus musculus

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 174

PARTICIPANT STOICHIOMETRY r36 644
type: Stoichiometry
physical entity: P110ACT
stoichiometric coefficient: 1.0

Ras s5 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r36 643
type: Stoichiometry
physical entity: p110
stoichiometric coefficient: 1.0

14-3-3 protein zeta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot Q6P4Z5 429
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot F1PBL1 417
xref: PTHR18860:SF7
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: uniprot W4Y0P1 105
xref: PTHR24057:SF0
organism: Strongylocentrotus purpuratus

uniprot Q8T9S7 246
type: UnificationXref
id: Q8T9S7
db: uniprot

Forkhead box protein O4
type: ProteinReference
xref: uniprot P98177 290
organism: Homo sapiens

Serine/threonine-protein kinase akt-1
type: ProteinReference
xref: PTHR24356:SF333
xref: uniprot Q17941 88
organism: Caenorhabditis elegans

uniprot A0A2I3TJU8 274
type: UnificationXref
id: A0A2I3TJU8
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF26
xref: uniprot D4AAI1 169
organism: Rattus norvegicus

TRANSCRIPTION_LEFT__scl_1-RIGHT__scl_1-_re53
type: TemplateReaction
product: scl-1
xref: TRANSCRIPTION
participant: scl-1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot A0A2I3TRC4 297
type: UnificationXref
id: A0A2I3TRC4
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 207
xref: PTHR19850:SF27
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 206
xref: PTHR19850:SF29
organism: Rattus norvegicus

FOXO s140 a282 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.63
comment: MODIFICATION_RESIDUE_NAME=

uniprot A0A1D5Q071 360
type: UnificationXref
id: A0A1D5Q071
db: uniprot

uniprot Q8BTI9 54
type: UnificationXref
id: Q8BTI9
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 183
xref: PTHR19850:SF28
organism: Ornithorhynchus anatinus

uniprot H2PZL0 321
type: UnificationXref
id: H2PZL0
db: uniprot

uniprot F6PVT7 178
type: UnificationXref
id: F6PVT7
db: uniprot

G protein subunit alpha 14
type: ProteinReference
xref: uniprot Q5EAP4 347
xref: PTHR10218:SF213
organism: Rattus norvegicus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A0G2K344 23
organism: Rattus norvegicus

Ras s216 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 227
xref: PTHR19850:SF29
organism: Danio rerio

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: uniprot Q7T3D3 352
organism: Danio rerio

ncbitaxon 7165 229
type: UnificationXref
id: 7165
db: ncbitaxon

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot Q6P549 372
organism: Mus musculus

NOS
type: Protein
entity reference: NOS
feature: NOS s136 a276 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot Q8T9S7 246
organism: Dictyostelium discoideum

Growth arrest and DNA damage-inducible protein GADD45 alpha
type: DnaReference
xref: PTHR10411:SF3
organism: Mus musculus

uniprot E2RPW6 10
type: UnificationXref
id: E2RPW6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VKI4 310
organism: Macaca mulatta

uniprot B2RSH2 300
type: UnificationXref
id: B2RSH2
db: uniprot

uniprot Q9UBS0 271
type: UnificationXref
id: Q9UBS0
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F1Q3M8 29
xref: PTHR10048:SF107
organism: Canis lupus familiaris

PKB s25 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PKB
stoichiometric coefficient: 1.0

Galpha
type: Protein
entity reference: Galpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa16 453
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot H9FVU5 42
xref: PTHR10048:SF107
organism: Macaca mulatta

14-3-3
type: Protein
entity reference: 14-3-3
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR23113:SF150
type: RelationshipXref
id: PTHR23113:SF150
db: PANTHER Family
relationship type: By Homology

uniprot F1P977 306
type: UnificationXref
id: F1P977
db: uniprot

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

ITK ligand
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s40 sa40 523
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: DnaReference
xref: PTHR10411:SF3
organism: Monodelphis domestica

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot F7BTW0 262
organism: Monodelphis domestica

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__IGFBP1-RIGHT__IGFBP1-_re52
control type: ACTIVATION
controller: FOXO

Guanine nucleotide-binding protein (G protein), beta 5
type: ProteinReference
xref: uniprot F7EBE7 184
xref: PTHR19850:SF36
organism: Xenopus tropicalis

Int Tyr Kin
type: Protein
feature: Int Tyr Kin s41 sa41 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s41 sa41 525
feature: Int Tyr Kin s41 sa41 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F6Y841 34
organism: Canis lupus familiaris

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 220

uniprot P08753 329
type: UnificationXref
id: P08753
db: uniprot

Cycline d
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

uniprot A0A1D5QB09 247
type: UnificationXref
id: A0A1D5QB09
db: uniprot

uniprot Q9Z1L0 57
type: UnificationXref
id: Q9Z1L0
db: uniprot

By Homology
type: RelationshipTypeVocabulary

Complex (JAK Ligand/JAK receptor)
type: Complex
component stoichiometry: JAK Ligand s77 sa69 STOICHIOMETRY ID COMPLEX
component stoichiometry: JAK receptor s78 sa70 STOICHIOMETRY ID COMPLEX
component: JAK Ligand
component: JAK receptor
feature: COMPLEX BINDING FEATURE s196 a399 482
feature: COMPLEX BINDING FEATURE s196 a399 484
cellular location: cytoplasm

uniprot Q9DC51 356
type: UnificationXref
id: Q9DC51
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TD14 380
xref: PTHR10155:SF3
organism: Monodelphis domestica

FOXO
type: Protein
entity reference: FOXO
feature: FOXO s140 a282 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Tyrosine-protein kinase receptor
type: ProteinReference
xref: uniprot A0A2I3RFV3 150
xref: PTHR24416:SF535
organism: Pan troglodytes

uniprot A1L271 160
type: UnificationXref
id: A1L271
db: uniprot

14-3-3 protein zeta/delta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot P63103 425
organism: Bos taurus

14-3-3 protein zeta/delta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot P63104 426
organism: Homo sapiens

Tyrosine-protein kinase JAK2
type: ProteinReference
xref: uniprot Q62689 21
xref: PTHR45807:SF1
organism: Rattus norvegicus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6SW23 30
organism: Gallus gallus

ncbitaxon 9258 36
type: UnificationXref
id: 9258
db: ncbitaxon

p110
type: Protein
entity reference: p110
feature: COMPLEX PARTICIPANT BINDING FEATURE s83 sa76 505
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot G5EGU1 319
type: UnificationXref
id: G5EGU1
db: uniprot

14-3-3 protein zeta/delta
type: ProteinReference
xref: uniprot P63102 424
xref: PTHR18860:SF7
organism: Rattus norvegicus

14-3-3 protein zeta/delta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot P63101 423
organism: Mus musculus

PI 3,4,5 P3 s24 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PI(3,4,5)P3
stoichiometric coefficient: 1.0

GDP s4 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2b
type: ProteinReference
xref: uniprot X1WDQ5 358
organism: Danio rerio

uniprot Q6PH57 227
type: UnificationXref
id: Q6PH57
db: uniprot

Gbetagamma s13 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbetagamma
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot P29387 199
organism: Mus musculus

uniprot P08754 330
type: UnificationXref
id: P08754
db: uniprot

CCND2 isoform 1
type: DnaReference
xref: PTHR10177:SF66
organism: Pan troglodytes

Gnb2 protein
type: ProteinReference
xref: PTHR19850:SF27
xref: uniprot Q5BJ11 221
organism: Danio rerio

JAK receptor s73 sa65 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.58
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 117

uniprot Q9Z1M4 272
type: UnificationXref
id: Q9Z1M4
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F6URW3 140
xref: PTHR23113:SF150
organism: Ornithorhynchus anatinus

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 52

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 224
xref: PTHR19850:SF31
organism: Mus musculus

Guanine nucleotide-binding protein G(T) subunit gamma-T1
type: ProteinReference
xref: PTHR13809:SF26
xref: uniprot Q61012 225
organism: Mus musculus

Complex (JAK receptor/JAK Ligand)
type: Complex
component stoichiometry: JAK receptor s69 sa62 STOICHIOMETRY ID COMPLEX
component stoichiometry: JAK Ligand s70 sa63 STOICHIOMETRY ID COMPLEX
component: JAK Ligand
component: JAK receptor
feature: COMPLEX BINDING FEATURE s190 a387 468
feature: COMPLEX BINDING FEATURE s190 a387 470
cellular location: cytoplasm

Bad
type: Protein
feature: Bad s135 a274 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q5BJ11 221
type: UnificationXref
id: Q5BJ11
db: uniprot

Prostaglandin E2 receptor EP1 subtype
type: ProteinReference
xref: uniprot P34995 401
xref: PTHR11866:SF3
organism: Homo sapiens

eco ECO:0000316 50
type: UnificationXref
id: ECO:0000316
db: eco

uniprot P62871 208
type: UnificationXref
id: P62871
db: uniprot

uniprot P19087 331
type: UnificationXref
id: P19087
db: uniprot

uniprot A0A0G2K344 23
type: UnificationXref
id: A0A0G2K344
db: uniprot

uniprot K7CZM1 145
type: UnificationXref
id: K7CZM1
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha 14
type: ProteinReference
xref: uniprot Q66JF0 351
xref: PTHR10218:SF213
organism: Xenopus tropicalis

NOS
type: ProteinReference
xref: P01205
comment: ENTITY_REFERENCE_NOTES= Long Name: NOS Synonym: Nitric oxide synthase Accession: P01205
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.NOS
member entity reference: Nitric oxide synthase, endothelial
member entity reference: Nitric oxide synthase
member entity reference: Nitric oxide synthase, inducible

GPCR s10 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GPCR
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot A0A3Q2TVV5 94
organism: Gallus gallus

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: uniprot F7ACT4 98
xref: PTHR24057:SF8
organism: Xenopus tropicalis

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: PTHR13809:SF28
xref: uniprot Q61017 226
organism: Mus musculus

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot Q8BSK8 270
organism: Mus musculus

DISSOCIATION_LEFT__Complex__GPCR_ligand_GPCR__Galpha_Gbetagamma_-RIGHT__Gbetagamma-_Complex__GPCR_ligand_GPCR__Galpha_-_r78
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 605
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 606
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 604
left: Complex (GPCR ligand/GPCR/ Galpha/Gbetagamma)
interaction type: DISSOCIATION
right: Complex (GPCR ligand/GPCR/ Galpha)
right: Gbetagamma

JAK Ligand
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s71 sa71 479
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F6TD14 380
type: UnificationXref
id: F6TD14
db: uniprot

Sex muscle abnormal protein 5
type: ProteinReference
xref: PTHR46037:SF1
xref: uniprot P29355 62
organism: Caenorhabditis elegans

uniprot P62872 209
type: UnificationXref
id: P62872
db: uniprot

JAK receptor s81 sa74 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.58
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Complex (GDP/Ras)
type: Complex
component stoichiometry: Ras s5 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s4 sa3 STOICHIOMETRY ID COMPLEX
component: Ras
component: GDP
feature: COMPLEX BINDING FEATURE s49 a64 518
feature: COMPLEX BINDING FEATURE s49 a64 520
cellular location: cytoplasm

PDK1 s16 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PDK1
stoichiometric coefficient: 1.0

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 33

STATE_TRANSITION_LEFT__SOS-RIGHT__SOS-_r12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 613
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 612
left: SOS
interaction type: STATE_TRANSITION
right: SOS

uniprot H2QFS6 384
type: UnificationXref
id: H2QFS6
db: uniprot

uniprot Q9R1E0 292
type: UnificationXref
id: Q9R1E0
db: uniprot

Complex (PI(3,4,5)P3/PKB)
type: Complex
component stoichiometry: PKB s23 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: PI 3,4,5 P3 s22 sa24 STOICHIOMETRY ID COMPLEX
component: PKB
component: PI(3,4,5)P3
feature: COMPLEX BINDING FEATURE s126 a254 444
feature: COMPLEX BINDING FEATURE s126 a254 442
cellular location: cytoplasm

IRS
type: Protein
entity reference: IRS
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

GSK3 s131 a268 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.75

JAK receptor s73 sa65 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: PTHR19850:SF25
xref: uniprot P49177 202
organism: Arabidopsis thaliana

uniprot Q803H5 232
type: UnificationXref
id: Q803H5
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A2I3T7A8 25
organism: Pan troglodytes

uniprot Q3ZCA7 346
type: UnificationXref
id: Q3ZCA7
db: uniprot

uniprot F7ACT4 98
type: UnificationXref
id: F7ACT4
db: uniprot

uniprot H2QNG6 41
type: UnificationXref
id: H2QNG6
db: uniprot

STATE_TRANSITION_LEFT__SOS-RIGHT__SOS-_r33
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 656
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 657
left: SOS
interaction type: STATE_TRANSITION
right: SOS

uniprot P36408 201
type: UnificationXref
id: P36408
db: uniprot

uniprot E2RB53 96
type: UnificationXref
id: E2RB53
db: uniprot

uniprot P42337 48
type: UnificationXref
id: P42337
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot F6VBA7 239
organism: Macaca mulatta

PTHR18860:SF106
type: RelationshipXref
id: PTHR18860:SF106
db: PANTHER Family
relationship type: By Homology

uniprot P50148 341
type: UnificationXref
id: P50148
db: uniprot

uniprot K7CRH3 288
type: UnificationXref
id: K7CRH3
db: uniprot

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: PTHR19850:SF25
xref: uniprot F5HH30 176
organism: Neurospora crassa

uniprot Q92569 393
type: UnificationXref
id: Q92569
db: uniprot

uniprot Q8BSK8 270
type: UnificationXref
id: Q8BSK8
db: uniprot

uniprot A0A3Q3ACS4 376
type: UnificationXref
id: A0A3Q3ACS4
db: uniprot

ncbitaxon 5786 111
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot P63096 343
type: UnificationXref
id: P63096
db: uniprot

uniprot P63103 425
type: UnificationXref
id: P63103
db: uniprot

STATE_TRANSITION_LEFT__PI_3,4,5_P3-RIGHT__PI_4,5_P2-_Pi-_r19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 571
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 572
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 573
left: PI(3,4,5)P3
interaction type: STATE_TRANSITION
right: Pi
right: PI(4,5)P2

Nitric oxide synthase, endothelial
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot Q62600 413
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Bad-RIGHT__ADP-_Bad-_r52
controller: Complex (PI(3,4,5)P3/PKB)

Insulin receptor substrate 1
type: ProteinReference
xref: uniprot E2RDB5 248
xref: PTHR10614:SF11
organism: Canis lupus familiaris

uniprot D4AE24 255
type: UnificationXref
id: D4AE24
db: uniprot

uniprot H9EPM1 99
type: UnificationXref
id: H9EPM1
db: uniprot

PTHR24057:SF0
type: RelationshipXref
id: PTHR24057:SF0
db: PANTHER Family
relationship type: By Homology

uniprot A0A3Q1LSD1 405
type: UnificationXref
id: A0A3Q1LSD1
db: uniprot

uniprot P70313 411
type: UnificationXref
id: P70313
db: uniprot

IR s31 sa33 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IR
stoichiometric coefficient: 1.0

uniprot P26308 198
type: UnificationXref
id: P26308
db: uniprot

PTHR24057:SF8
type: RelationshipXref
id: PTHR24057:SF8
db: PANTHER Family
relationship type: By Homology

Int Tyr Kin s57 sa52 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.51
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY r9 565
type: Stoichiometry
physical entity: PI(3,4,5)P3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 567
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

uniprot F1MDX9 237
type: UnificationXref
id: F1MDX9
db: uniprot

PARTICIPANT STOICHIOMETRY r9 566
type: Stoichiometry
physical entity: PI(3,4)P2
stoichiometric coefficient: 1.0

14-3-3 protein zeta
type: ProteinReference
xref: uniprot P29310 422
xref: PTHR18860:SF106
organism: Drosophila melanogaster

uniprot Q61011 224
type: UnificationXref
id: Q61011
db: uniprot

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P31751 85
organism: Homo sapiens

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31750 84
xref: PTHR24356:SF171
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UJE8 309
organism: Monodelphis domestica

Bos taurus
type: BioSource
xref: ncbitaxon 9913 9

uniprot A0A2I3S4R3 296
type: UnificationXref
id: A0A2I3S4R3
db: uniprot

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q9WUA6 91
xref: PTHR24356:SF190
organism: Mus musculus

IR
type: Protein
entity reference: IR
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa33 475
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF171
xref: uniprot H2Q486 264
organism: Pan troglodytes

Grb2 s76 sa68 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31749 83
organism: Homo sapiens

Int Tyr Kin s41 sa41 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.51
comment: MODIFICATION_RESIDUE_NAME=

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot B1H2U0 236
xref: PTHR12305:SF81
organism: Xenopus tropicalis

5PtaseI, isoform F
type: ProteinReference
xref: uniprot B7Z0Q1 362
organism: Drosophila melanogaster

PTHR24416:SF535
type: RelationshipXref
id: PTHR24416:SF535
db: PANTHER Family
relationship type: By Homology

uniprot F1NT98 238
type: UnificationXref
id: F1NT98
db: uniprot

JAK receptor s78 sa70 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

14-3-3-like protein 2
type: ProteinReference
xref: PTHR18860:SF106
xref: uniprot Q20655 427
organism: Caenorhabditis elegans

G protein alpha i subunit
type: ProteinReference
xref: uniprot P20353 332
organism: Drosophila melanogaster

Int Tyr Kin s50 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Int Tyr Kin
stoichiometric coefficient: 1.0

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 165

uniprot P63102 424
type: UnificationXref
id: P63102
db: uniprot

p85 s58 sa53 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p85
stoichiometric coefficient: 1.0

p85
type: Protein
entity reference: p85
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa1 555
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r8 570
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot F1A421 175
xref: PTHR19850:SF25
organism: Dictyostelium purpureum

Insulin receptor
type: ProteinReference
xref: uniprot P15208 156
xref: PTHR24416:SF535
organism: Mus musculus

uniprot P34980 400
type: UnificationXref
id: P34980
db: uniprot

p110
type: Protein
entity reference: p110
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa2 557
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F1MHB9 366
type: UnificationXref
id: F1MHB9
db: uniprot

JAK receptor s78 sa70 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.58
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Int Tyr Kin s57 sa52 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.81
comment: MODIFICATION_RESIDUE_NAME=

STATE_TRANSITION_LEFT__ATP-_Complex__JAK_Ligand_JAK_receptor_-RIGHT__ADP-_Complex__JAK_Ligand_JAK_receptor_-_r82
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 695
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 697
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 694
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 696
left: ATP
left: Complex (JAK Ligand/JAK receptor)
interaction type: STATE_TRANSITION
right: ADP
right: Complex (JAK Ligand/JAK receptor)

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot E2RMD8 258
organism: Canis lupus familiaris

Caspase 9 s133 a270 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot P30677 336
organism: Mus musculus

JAK receptor s81 sa74 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 31

GPCR
type: Protein
entity reference: GPCR
feature: COMPLEX PARTICIPANT BINDING FEATURE s62 sa56 531
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F6RIM7 307
type: UnificationXref
id: F6RIM7
db: uniprot

Caspase 9 s132 a269 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot Q9WVH4 294
type: UnificationXref
id: Q9WVH4
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F7GT47 14
xref: PTHR45807:SF1
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r53 679
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E1BCP6 8
xref: PTHR45807:SF1
organism: Bos taurus

PKB
type: ProteinReference
xref: P01179
standard name: Protein kinase B
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.PKB
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: PKB Synonym: Akt,Protein kinase B Accession: P01179
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC-gamma serine/threonine-protein kinase
member entity reference: RAC-alpha serine/threonine-protein kinase
member entity reference: RAC-beta serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase akt-1

uniprot Q20655 427
type: UnificationXref
id: Q20655
db: uniprot

PARTICIPANT STOICHIOMETRY r23 668
type: Stoichiometry
physical entity: Complex (p85/p110)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 667
type: Stoichiometry
physical entity: p110
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 666
type: Stoichiometry
physical entity: p85
stoichiometric coefficient: 1.0

uniprot P06213 153
type: UnificationXref
id: P06213
db: uniprot

Guanine nucleotide-binding protein G(t) subunit alpha-2
type: ProteinReference
xref: uniprot P19087 331
organism: Homo sapiens

uniprot P08556 121
type: UnificationXref
id: P08556
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QB09 247
xref: PTHR10614:SF11
organism: Macaca mulatta

PTHR15593:SF2
type: RelationshipXref
id: PTHR15593:SF2
db: PANTHER Family
relationship type: By Homology

PIK3R5 isoform 2
type: ProteinReference
xref: PTHR15593:SF2
xref: uniprot A0A2J8MGP0 394
organism: Pan troglodytes

PTHR24416:SF525
type: RelationshipXref
id: PTHR24416:SF525
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5KI86 222
xref: PTHR19850:SF25
organism: Cryptococcus neoformans

Guanine nucleotide binding protein, beta subunit
type: ProteinReference
xref: PTHR19850:SF25
xref: uniprot E9FUX0 173
organism: Daphnia pulex

PARTICIPANT STOICHIOMETRY r53 681
type: Stoichiometry
physical entity: NOS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 680
type: Stoichiometry
physical entity: NOS
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PI_4,5_P2-RIGHT__PI_3,4,5_P3-_ADP-_r18
controller: Complex (JAK Ligand/JAK receptor/ p85/p110)

PARTICIPANT STOICHIOMETRY r53 682
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__GTP-_Complex__GDP_Ras_-RIGHT__Complex__Ras_GTP_-_GDP-_r35
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 646
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 647
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 645
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 648
left: GTP
left: Complex (GDP/Ras)
interaction type: STATE_TRANSITION
right: Complex (Ras/GTP)
right: GDP

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF1
xref: uniprot F6WH53 12
organism: Monodelphis domestica

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q5F352 132
organism: Gallus gallus

IR ligand
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa32 473
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot A0A2I3SYV7 4
xref: PTHR45807:SF1
organism: Pan troglodytes

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot Q02384 146
xref: PTHR23113:SF150
organism: Mus musculus

PKB s23 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PKB
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 178
xref: PTHR19850:SF29
organism: Monodelphis domestica

uniprot D4AAI1 169
type: UnificationXref
id: D4AAI1
db: uniprot

PKB
type: Protein
entity reference: PKB
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa25 445
feature: PKB s23 sa25 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot F7AQR3 314
organism: Macaca mulatta

THO complex subunit, putative
type: ProteinReference
xref: PTHR19850:SF25
xref: uniprot B7Q3T6 164
organism: Ixodes scapularis

uniprot E1BBJ7 364
type: UnificationXref
id: E1BBJ7
db: uniprot

uniprot W4Y0P1 105
type: UnificationXref
id: W4Y0P1
db: uniprot

ncbitaxon 44689 120
type: UnificationXref
id: 44689
db: ncbitaxon

ITK ligand
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s46 sa45 515
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6R8N3 78
xref: PTHR24356:SF190
organism: Macaca mulatta

uniprot F7DUD6 35
type: UnificationXref
id: F7DUD6
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6VXG1 32
organism: Xenopus tropicalis

Complex (p85/p110)
type: Complex
component stoichiometry: p110 s3 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: p85 s2 sa1 STOICHIOMETRY ID COMPLEX
component: p85
component: p110
feature: COMPLEX BINDING FEATURE s21 a22 554
feature: COMPLEX BINDING FEATURE s21 a22 556
cellular location: cytoplasm

IGFBP1
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Forkhead box protein O1
type: ProteinReference
xref: uniprot G3V7R4 285
xref: PTHR45767:SF1
organism: Rattus norvegicus

uniprot A0A1D5QG31 295
type: UnificationXref
id: A0A1D5QG31
db: uniprot

PI 3,4,5 P3 s17 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PI(3,4,5)P3
stoichiometric coefficient: 1.0

ncbitaxon 7955 65
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot E2RPM8 151
type: UnificationXref
id: E2RPM8
db: uniprot

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P01111 115
organism: Homo sapiens

uniprot Q9JID2 357
type: UnificationXref
id: Q9JID2
db: uniprot

G1/S-specific cyclin-D1
type: DnaReference
xref: PTHR10177:SF67
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5F3B5 348
xref: PTHR10218:SF316
organism: Gallus gallus

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__GADD45-RIGHT__GADD45-_re50
control type: ACTIVATION
controller: FOXO

Uncharacterized protein
type: DnaReference
xref: PTHR11551:SF6
organism: Macaca mulatta

PTHR24070:SF388
type: RelationshipXref
id: PTHR24070:SF388
db: PANTHER Family
relationship type: By Homology

S6K s128 a256 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.88

GPCR ligand
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s65 sa59 493
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Forkhead box O3
type: ProteinReference
xref: uniprot D3ZBQ1 278
xref: PTHR45767:SF4
organism: Rattus norvegicus

Ribosomal protein S6 kinase
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot H2QDK7 265
organism: Pan troglodytes

ncbitaxon 9606 17
type: UnificationXref
id: 9606
db: ncbitaxon

Complex (IR ligand/IR/ IRS)
type: Complex
component stoichiometry: IR ligand s30 sa32 STOICHIOMETRY ID COMPLEX
component stoichiometry: IRS s32 sa34 STOICHIOMETRY ID COMPLEX
component stoichiometry: IR s31 sa33 STOICHIOMETRY ID COMPLEX
component: IR
component: IR ligand
component: IRS
feature: COMPLEX BINDING FEATURE s156 a311 474
feature: COMPLEX BINDING FEATURE s156 a311 472
feature: COMPLEX BINDING FEATURE s156 a311 476
cellular location: cytoplasm

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 232
xref: PTHR19850:SF29
organism: Danio rerio

Insulin-like growth factor-binding protein 1
type: DnaReference
xref: PTHR11551:SF6
organism: Homo sapiens

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot H2R8U9 143
organism: Pan troglodytes

Galpha s213 sa57 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Galpha
stoichiometric coefficient: 1.0

uniprot H2QMN4 322
type: UnificationXref
id: H2QMN4
db: uniprot

uniprot F6THW2 308
type: UnificationXref
id: F6THW2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45767:SF4
xref: uniprot F6UMX8 283
organism: Macaca mulatta

G protein subunit beta 5
type: ProteinReference
xref: uniprot E2RHY4 172
xref: PTHR19850:SF36
organism: Canis lupus familiaris

p85 s2 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p85
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot F6PGQ1 97
organism: Monodelphis domestica

INPPL1 isoform 1
type: ProteinReference
xref: PTHR46051:SF2
xref: uniprot H2Q4C6 368
organism: Pan troglodytes

ncbitaxon 367110 125
type: UnificationXref
id: 367110
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r12 613
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

Bad s135 a274 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

PARTICIPANT STOICHIOMETRY r12 612
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

JAK receptor
type: Protein
feature: JAK receptor s69 sa62 rs1
feature: JAK receptor s69 sa62 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s69 sa62 469
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

14-3-3
type: ProteinReference
xref: P01206
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: 14-3-3 Synonym: GF14 Accession: P01206
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.14-3-3
member entity reference: Uncharacterized protein
member entity reference: 14-3-3 protein zeta/delta
member entity reference: AGAP007643-PA
member entity reference: 14-3-3-like protein 2
member entity reference: 14-3-3 zeta
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
member entity reference: 14-3-3 protein zeta

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF28
xref: uniprot D3ZLD6 168
organism: Rattus norvegicus

uniprot Q8WYR1 397
type: UnificationXref
id: Q8WYR1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_GSK3-RIGHT__GSK3-_ADP-_r50
controller: Complex (PI(3,4,5)P3/PKB)

TRANSCRIPTION_LEFT__Cyclin_d-RIGHT__Cycline_d-_re51
type: TemplateReaction
product: Cycline d
xref: TRANSCRIPTION
participant: Cycline d
participant: Cyclin d
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 123

uniprot F7CTP1 181
type: UnificationXref
id: F7CTP1
db: uniprot

Insulin-like receptor
type: ProteinReference
xref: uniprot Q968Y9 157
xref: PTHR24416:SF525
organism: Caenorhabditis elegans

14-3-3 zeta
type: ProteinReference
xref: uniprot A8XQR9 416
xref: PTHR18860:SF106
organism: Caenorhabditis briggsae

uniprot P30677 336
type: UnificationXref
id: P30677
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P26450 390
organism: Mus musculus

uniprot F7H6T7 187
type: UnificationXref
id: F7H6T7
db: uniprot

PI(3,4,5)P3
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa20 507
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Int Tyr Kin s41 sa41 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.81
comment: MODIFICATION_RESIDUE_NAME=

STATE_TRANSITION_LEFT__Complex__PI_3,4,5_P3_PDK1_-RIGHT__Complex__PI_3,4,5_P3_PDK1_ACT_-_r45
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 608
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 607
left: Complex (PI(3,4,5)P3/PDK1)
interaction type: STATE_TRANSITION
right: Complex (PI(3,4,5)P3/PDK1 ACT)

Uncharacterized protein
type: ProteinReference
xref: PTHR15593:SF2
xref: uniprot F6VTR8 396
organism: Macaca mulatta

ncbitaxon 10090 19
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot Q28FH0 345
type: UnificationXref
id: Q28FH0
db: uniprot

uniprot P67999 268
type: UnificationXref
id: P67999
db: uniprot

PARTICIPANT STOICHIOMETRY r8 568
type: Stoichiometry
physical entity: PI(3,4,5)P3
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot Q20636 218
xref: PTHR19850:SF36
organism: Caenorhabditis elegans

JAK receptor s72 a122 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.58
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY r8 569
type: Stoichiometry
physical entity: PI(4,5)P2
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5PX66 359
organism: Gallus gallus

S6K
type: Protein
entity reference: S6K
feature: S6K s128 a256 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q5EAP4 347
type: UnificationXref
id: Q5EAP4
db: uniprot

PDK1 ACT s18 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PDK1 ACT
stoichiometric coefficient: 1.0

uniprot H2Q9G5 188
type: UnificationXref
id: H2Q9G5
db: uniprot

Grb2 s42 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ATP-_S6K-RIGHT__S6K-_ADP-_r49
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 588
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 585
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 587
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 586
left: ATP
left: S6K
interaction type: STATE_TRANSITION
right: ADP
right: S6K

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
type: ProteinReference
xref: uniprot Q7ZW82 353
organism: Danio rerio

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SOS-RIGHT__SOS-_r12
controller: Complex (ITK ligand/Int Tyr Kin/ Grb2)

uniprot F6UJE8 309
type: UnificationXref
id: F6UJE8
db: uniprot

uniprot E2R2S8 171
type: UnificationXref
id: E2R2S8
db: uniprot

uniprot E2RTA1 281
type: UnificationXref
id: E2RTA1
db: uniprot

SCP-Like extracellular protein
type: DnaReference
organism: Caenorhabditis elegans

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 106

SCP-Like extracellular protein
type: DnaReference
organism: Caenorhabditis elegans

SCP-Like extracellular protein
type: DnaReference
organism: Caenorhabditis elegans

Ras-like protein 2
type: ProteinReference
xref: uniprot P01120 118
xref: PTHR24070:SF17
organism: Saccharomyces cerevisiae

Complex (Ras/GDP)
type: Complex
component stoichiometry: Ras s6 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s9 sa12 STOICHIOMETRY ID COMPLEX
component: GDP
component: Ras
feature: COMPLEX BINDING FEATURE s94 a190 440
feature: COMPLEX BINDING FEATURE s94 a190 438
cellular location: cytoplasm

Bad
type: Protein
feature: Bad s134 a273 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Ras-like protein 1
type: ProteinReference
xref: uniprot P01119 116
xref: PTHR24070:SF17
organism: Saccharomyces cerevisiae

SCP-Like extracellular protein
type: DnaReference
organism: Caenorhabditis elegans

Complex (PI(3,4,5)P3/PDK1 ACT)
type: Complex
component stoichiometry: PI 3,4,5 P3 s17 sa22 STOICHIOMETRY ID COMPLEX
component stoichiometry: PDK1 ACT s18 sa23 STOICHIOMETRY ID COMPLEX
component: PI(3,4,5)P3
component: PDK1 ACT
feature: COMPLEX BINDING FEATURE s121 a241 464
feature: COMPLEX BINDING FEATURE s121 a241 466
cellular location: cytoplasm

uniprot B1H2U0 236
type: UnificationXref
id: B1H2U0
db: uniprot

uniprot F1Q4F8 75
type: UnificationXref
id: F1Q4F8
db: uniprot

uniprot F7GT47 14
type: UnificationXref
id: F7GT47
db: uniprot

Tyrosine-protein kinase JAK2
type: ProteinReference
xref: uniprot Q62120 18
xref: PTHR45807:SF1
organism: Mus musculus

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: PTHR19850:SF25
xref: uniprot A7EDU2 162
organism: Sclerotinia sclerotiorum

JAK Ligand
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s77 sa69 483
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5QGM1 404
type: UnificationXref
id: A0A1D5QGM1
db: uniprot

JAK receptor
type: Protein
feature: JAK receptor s81 sa74 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s81 sa74 501
feature: JAK receptor s81 sa74 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Caspase-9
type: Protein
entity reference: Caspase-9
feature: Caspase 9 s132 a269 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot G7MGQ5 383
type: UnificationXref
id: G7MGQ5
db: uniprot

uniprot A0A0G2K5T3 24
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

Int Tyr Kin
type: Protein
feature: Int Tyr Kin s8 a8 rs2
feature: Int Tyr Kin s8 a8 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P49841 101
type: UnificationXref
id: P49841
db: uniprot

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 120

uniprot P29310 422
type: UnificationXref
id: P29310
db: uniprot

Gbetagamma
type: ProteinReference
xref: P01188
standard name: G protein, beta and gamma subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.G_sub__beta__gamma_
comment: ENTITY_REFERENCE_NOTES= Long Name: Gbetagamma Synonym: Heterotrimeric G-protein beta gamma subunit Accession: P01188
member entity reference: Guanine nucleotide-binding protein (G protein), beta 5
member entity reference: Gbeta5
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: Guanine nucleotide-binding protein subunit beta-5
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Guanine nucleotide-binding protein subunit beta-4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
member entity reference: Guanine nucleotide-binding protein beta subunit
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: G protein subunit beta 3
member entity reference: Uncharacterized protein
member entity reference: G protein subunit beta 4
member entity reference: G-protein beta subunit
member entity reference: G protein subunit beta 1
member entity reference: Gnb2 protein
member entity reference: THO complex subunit, putative
member entity reference: AGAP005912-PA
member entity reference: Guanine nucleotide-binding protein G(T) subunit gamma-T1
member entity reference: G protein subunit beta 2
member entity reference: Guanine nucleotide-binding protein subunit beta-1
member entity reference: Gnb1l protein
member entity reference: AGAP005911-PA
member entity reference: Guanine nucleotide-binding protein subunit beta-2
member entity reference: GNB4 protein
member entity reference: Guanine nucleotide-binding protein subunit beta-5a
member entity reference: AGAP005913-PA
member entity reference: G protein subunit beta 5
member entity reference: Guanine nucleotide binding protein, beta subunit

JAK Ligand
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s74 sa66 487
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: PTHR24351:SF48
xref: uniprot P67999 268
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_S6K-RIGHT__S6K-_ADP-_r49
controller: Complex (PI(3,4,5)P3/PDK1 ACT)

JAK receptor s72 a122 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

EGL-30
type: ProteinReference
xref: uniprot G5EGU1 319
xref: PTHR10218:SF329
organism: Caenorhabditis elegans

FOXO
type: Protein
entity reference: FOXO
feature: ACTIVE 59
feature: FOXO s138 a281 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

IRS s36 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IRS
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Complex__JAK_Ligand_JAK_receptor_-_Grb2-RIGHT__Complex__JAK_Ligand_JAK_receptor__Grb2_-_r79
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 596
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 595
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 597
left: Grb2
left: Complex (JAK Ligand/JAK receptor)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (JAK Ligand/JAK receptor/ Grb2)

Cyclin D1
type: DnaReference
xref: PTHR10177:SF67
organism: Bos taurus

ITK ligand
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s56 sa51 431
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Caspase-9
type: ProteinReference
xref: P01197
comment: ENTITY_REFERENCE_NOTES= Long Name: Caspase-9 Synonym: Apaf-3,Cysteine containing aspartate specific protease 9,Cysteine-containing aspartate specific protease 9,ICE-LAP6,Mch6 Accession: P01197
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PI3 kinase pathway.PROTEIN.GENERIC.Caspase-9
member entity reference: Caspase 9, isoform CRA_a
member entity reference: CASP9 isoform 4
member entity reference: Caspase-9
member entity reference: Uncharacterized protein

Complex (JAK Ligand/JAK receptor/ p85/p110)
type: Complex
component stoichiometry: JAK Ligand s80 sa73 STOICHIOMETRY ID COMPLEX
component stoichiometry: p85 s82 sa75 STOICHIOMETRY ID COMPLEX
component stoichiometry: p110 s83 sa76 STOICHIOMETRY ID COMPLEX
component stoichiometry: JAK receptor s81 sa74 STOICHIOMETRY ID COMPLEX
component: JAK Ligand
component: p110
component: JAK receptor
component: p85
feature: COMPLEX BINDING FEATURE s198 a403 498
feature: COMPLEX BINDING FEATURE s198 a403 500
feature: COMPLEX BINDING FEATURE s198 a403 502
feature: COMPLEX BINDING FEATURE s198 a403 504
cellular location: cytoplasm

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s217 sa10 539
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

14-3-3
type: Protein
entity reference: 14-3-3
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa29 463
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(T) subunit gamma-T1
type: ProteinReference
xref: PTHR13809:SF26
xref: uniprot P02698 194
organism: Bos taurus

Prostaglandin E2 receptor EP3 subtype
type: ProteinReference
xref: PTHR11866:SF10
xref: uniprot P34980 400
organism: Rattus norvegicus

ADP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P60483 243
type: UnificationXref
id: P60483
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

uniprot F7FD32 316
type: UnificationXref
id: F7FD32
db: uniprot

uniprot Q12778 291
type: UnificationXref
id: Q12778
db: uniprot

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: uniprot F1NT98 238
xref: PTHR12305:SF81
organism: Gallus gallus

uniprot Q6P4Z5 429
type: UnificationXref
id: Q6P4Z5
db: uniprot

PARTICIPANT STOICHIOMETRY r78 605
type: Stoichiometry
physical entity: Gbetagamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r78 606
type: Stoichiometry
physical entity: Complex (GPCR ligand/GPCR/ Galpha)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r78 604
type: Stoichiometry
physical entity: Complex (GPCR ligand/GPCR/ Galpha/Gbetagamma)
stoichiometric coefficient: 1.0

uniprot Q10282 217
type: UnificationXref
id: Q10282
db: uniprot

uniprot A0NBC2 415
type: UnificationXref
id: A0NBC2
db: uniprot

uniprot F6YCI3 141
type: UnificationXref
id: F6YCI3
db: uniprot

Insulin receptor substrate 1
type: ProteinReference
xref: uniprot P35569 252
xref: PTHR10614:SF11
organism: Mus musculus

Insulin receptor substrate 1
type: ProteinReference
xref: uniprot P35568 251
xref: PTHR10614:SF11
organism: Homo sapiens

uniprot O14610 192
type: UnificationXref
id: O14610
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
type: ProteinReference
xref: uniprot F7BZL6 381
xref: PTHR10155:SF3
organism: Macaca mulatta

PTEN
type: Protein
entity reference: PTEN
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q9W3J1 234
type: UnificationXref
id: Q9W3J1
db: uniprot

GPCR
type: Protein
entity reference: GPCR
feature: COMPLEX PARTICIPANT BINDING FEATURE s66 sa60 495
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: uniprot O46404 387
xref: PTHR10155:SF2
organism: Bos taurus

uniprot F6VL43 311
type: UnificationXref
id: F6VL43
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E2RPW6 10
xref: PTHR45807:SF1
organism: Canis lupus familiaris

HETERODIMER_ASSOCIATION_LEFT__Complex__ITK_ligand_Int_Tyr_Kin_-_Complex__p85_p110_-RIGHT__Complex__ITK_ligand_Int_Tyr_Kin__p85_p110_-_r72
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 632
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 630
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 631
left: Complex (p85/p110)
left: Complex (ITK ligand/Int Tyr Kin)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (ITK ligand/Int Tyr Kin/ p85/p110)

uniprot F7E427 183
type: UnificationXref
id: F7E427
db: uniprot

Insulin receptor substrate 1
type: ProteinReference
xref: uniprot P35570 253
xref: PTHR10614:SF11
organism: Rattus norvegicus

uniprot P47196 86
type: UnificationXref
id: P47196
db: uniprot

uniprot H2QUX9 190
type: UnificationXref
id: H2QUX9
db: uniprot