alpha Synuclein s29 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

CSNK1G2 protein
type: ProteinReference
xref: PTHR11909:SF157
xref: uniprot A7MB90 1118
organism: Bos taurus

uniprot Q384T8 664
type: UnificationXref
id: Q384T8
db: uniprot

uniprot Q6P7Z3 689
type: UnificationXref
id: Q6P7Z3
db: uniprot

Casein kinase 1-like protein 10
type: ProteinReference
xref: PTHR11909:SF383
xref: uniprot Q9LW62 1194
organism: Arabidopsis thaliana

uniprot P37377 403
type: UnificationXref
id: P37377
db: uniprot

PTHR24068:SF43
type: RelationshipXref
id: PTHR24068:SF43
db: PANTHER Family
relationship type: By Homology

Serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q8W1K7 1183
xref: PTHR11909:SF391
organism: Chlamydomonas reinhardtii

uniprot F7DUU5 571
type: UnificationXref
id: F7DUU5
db: uniprot

uniprot O74135 1139
type: UnificationXref
id: O74135
db: uniprot

uniprot P78368 1158
type: UnificationXref
id: P78368
db: uniprot

Fyn kinase
type: ProteinReference
xref: P01235
comment: ENTITY_REFERENCE_NOTES= Long Name: Fyn kinase Synonym: Synonym not specified Accession: P01235
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.Fyn kinase
member entity reference: Tyrosine-protein kinase
member entity reference: Tyrosine-protein kinase Fyn
member entity reference: Tyrosine-protein kinase fynb
member entity reference: Tyrosine-protein kinase FRK
member entity reference: Tyrosine-protein kinase fyna

uniprot P09324 797
type: UnificationXref
id: P09324
db: uniprot

Casein kinase II, putative
type: ProteinReference
xref: PTHR24054:SF46
xref: uniprot Q38D21 926
organism: Trypanosoma brucei

uniprot P92208 439
type: UnificationXref
id: P92208
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot L7N050 105
xref: PTHR19375:SF210
organism: Canis lupus familiaris

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot Q4QC13 676
organism: Leishmania major

Synphilin s3 sa5 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Proteasome subunit beta type-1
type: ProteinReference
xref: uniprot P20618 619
xref: PTHR11599:SF59
organism: Homo sapiens

uniprot E2RBB8 760
type: UnificationXref
id: E2RBB8
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 18

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot E2RKR4 547
xref: PTHR11599:SF10
organism: Canis lupus familiaris

uniprot E9AEZ4 882
type: UnificationXref
id: E9AEZ4
db: uniprot

uniprot E2QX17 545
type: UnificationXref
id: E2QX17
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF14
xref: uniprot A9SDV6 537
organism: Physcomitrella patens

Proteasome endopeptidase complex
type: ProteinReference
xref: uniprot E2RTW7 550
xref: PTHR11599:SF13
organism: Giardia intestinalis

Casein kinase 1 delta
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot F1Q126 1124
organism: Canis lupus familiaris

uniprot P49674 1154
type: UnificationXref
id: P49674
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F1PXS7 275
organism: Canis lupus familiaris

uniprot F6S2Q4 561
type: UnificationXref
id: F6S2Q4
db: uniprot

G1/S-specific cyclin-E2
type: ProteinReference
xref: PTHR10177:SF70
xref: uniprot Q9Z238 358
organism: Mus musculus

PTHR24068:SF67
type: RelationshipXref
id: PTHR24068:SF67
db: PANTHER Family
relationship type: By Homology

Casein kinase II subunit alpha
type: ProteinReference
xref: uniprot P68399 922
xref: PTHR24054:SF16
organism: Bos taurus

Y125 alpha Synuclein s78 sa21 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y125
feature location: Y125 alpha Synuclein s78 sa21 rs2 Y125
comment: MODIFICATION_RESIDUE_NAME=Y125
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.69

Y125 alpha Synuclein s40 a57 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y125
feature location: Y125 alpha Synuclein s40 a57 rs2 Y125
comment: MODIFICATION_RESIDUE_NAME=Y125
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.69

By Homology
type: RelationshipTypeVocabulary

uniprot F6ZTS0 425
type: UnificationXref
id: F6ZTS0
db: uniprot

Complex (N Y125/alpha-Synuclein)
type: Complex
component stoichiometry: alpha Synuclein s78 sa21 STOICHIOMETRY ID COMPLEX
component stoichiometry: N Y125 s76 sa20 STOICHIOMETRY ID COMPLEX
component: alpha-Synuclein
component: N Y125
feature: COMPLEX BINDING FEATURE s101 a124 1209
feature: COMPLEX BINDING FEATURE s101 a124 1207
cellular location: intracellular

uniprot Q23237 657
type: UnificationXref
id: Q23237
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 175

uniprot P54367 1155
type: UnificationXref
id: P54367
db: uniprot

Proteasome subunit beta
type: ProteinReference
xref: uniprot H2XVD5 590
xref: PTHR11599:SF44
organism: Ciona intestinalis

uniprot E2R2N2 273
type: UnificationXref
id: E2R2N2
db: uniprot

Tyrosine-protein kinase Yes
type: ProteinReference
xref: uniprot Q04736 811
xref: PTHR24418:SF90
organism: Mus musculus

Probable mediator of RNA polymerase II transcription subunit 37e
type: ProteinReference
xref: PTHR19375:SF413
xref: uniprot P22953 152
organism: Arabidopsis thaliana

Uncharacterized protein
type: ProteinReference
xref: PTHR24068:SF67
xref: uniprot E2RKT9 483
organism: Canis lupus familiaris

uniprot P42207 513
type: UnificationXref
id: P42207
db: uniprot

PARTICIPANT STOICHIOMETRY r31 1347
type: Stoichiometry
physical entity: Complex (14-3-3/alpha-Synuclein)
stoichiometric coefficient: 1.0

Heat shock 70 kDa protein 1B
type: ProteinReference
xref: PTHR19375:SF223
xref: uniprot P17879 144
organism: Mus musculus

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot Q38CL5 668
xref: PTHR11599:SF14
organism: Trypanosoma brucei

uniprot Q10N20 298
type: UnificationXref
id: Q10N20
db: uniprot

Cullin-1
type: ProteinReference
xref: PTHR11932:SF81
xref: uniprot Q1KMU1 1089
organism: Xenopus tropicalis

uniprot P17156 139
type: UnificationXref
id: P17156
db: uniprot

p38 MAPK
type: Protein
entity reference: p38 MAPK
feature: p38 MAPK s73 a100 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot O76324 1140
type: UnificationXref
id: O76324
db: uniprot

PARTICIPANT STOICHIOMETRY r31 1346
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r31 1345
type: Stoichiometry
physical entity: 14-3-3
stoichiometric coefficient: 1.0

uniprot P27420 153
type: UnificationXref
id: P27420
db: uniprot

uniprot Q90593 236
type: UnificationXref
id: Q90593
db: uniprot

PARTICIPANT STOICHIOMETRY r3 1304
type: Stoichiometry
physical entity: MPP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 1303
type: Stoichiometry
physical entity: MPP+
stoichiometric coefficient: 1.0

Proteasome subunit alpha type-4
type: ProteinReference
xref: PTHR11599:SF13
xref: uniprot P34119 637
organism: Dictyostelium discoideum

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot P41969 849
organism: Mus musculus

uniprot Q01621 810
type: UnificationXref
id: Q01621
db: uniprot

uniprot P67962 1157
type: UnificationXref
id: P67962
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF90
xref: uniprot A7MB57 758
organism: Bos taurus

uniprot P63102 1032
type: UnificationXref
id: P63102
db: uniprot

HSPA9 isoform 1
type: ProteinReference
xref: uniprot H2QRK8 98
xref: PTHR19375:SF184
organism: Pan troglodytes

Septin-2
type: ProteinReference
xref: uniprot Q2NKY7 519
organism: Bos taurus

Proteasome subunit alpha type-7
type: ProteinReference
xref: uniprot P34120 638
xref: PTHR11599:SF15
organism: Dictyostelium discoideum

NADP-reducing hydrogenase, subunit A
type: ProteinReference
xref: uniprot Q9WXM7 961
organism: Thermotoga maritima

uniprot H2RA86 285
type: UnificationXref
id: H2RA86
db: uniprot

uniprot Q383E9 191
type: UnificationXref
id: Q383E9
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q2TY19 415
xref: PTHR24055:SF222
organism: Gallus gallus

CDCrel-1
type: Protein
entity reference: CDCrel-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s107 sa38 1254
feature: CDCrel 1 s107 sa38 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q10284 185
type: UnificationXref
id: Q10284
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q95NE7 344
organism: Pan troglodytes

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot Q4QC00 675
xref: PTHR11599:SF14
organism: Leishmania major

Heat shock 70 kDa protein cognate 2
type: ProteinReference
xref: uniprot P11146 132
xref: PTHR19375:SF388
organism: Drosophila melanogaster

Heat shock 70 kDa protein cognate 4
type: ProteinReference
xref: PTHR19375:SF457
xref: uniprot P11147 133
organism: Drosophila melanogaster

uniprot Q9US13 257
type: UnificationXref
id: Q9US13
db: uniprot

Heat shock cognate 71 kDa protein
type: ProteinReference
xref: uniprot P11142 131
xref: PTHR19375:SF379
organism: Homo sapiens

Casein kinase II subunit beta
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot Q91398 941
organism: Danio rerio

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot P16474 136
organism: Saccharomyces cerevisiae

uniprot P20163 147
type: UnificationXref
id: P20163
db: uniprot

Heat shock 70 kDa protein F, mitochondrial
type: ProteinReference
xref: uniprot P11141 130
xref: PTHR19375:SF184
organism: Caenorhabditis elegans

uniprot P48349 1022
type: UnificationXref
id: P48349
db: uniprot

uniprot Q8WYJ6 522
type: UnificationXref
id: Q8WYJ6
db: uniprot

uniprot P14659 135
type: UnificationXref
id: P14659
db: uniprot

Proteasome subunit beta
type: ProteinReference
xref: uniprot H2R3I7 588
xref: PTHR11599:SF41
organism: Pan troglodytes

uniprot Q55154 205
type: UnificationXref
id: Q55154
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24068:SF67
xref: uniprot H2Q7D5 487
organism: Pan troglodytes

Cytosolic HSP70
type: ProteinReference
xref: uniprot A8BCR6 41
xref: PTHR19375:SF395
organism: Giardia intestinalis

Chaperone protein DnaK
type: ProteinReference
xref: uniprot O67118 111
xref: PTHR19375:SF184
organism: Aquifex aeolicus

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot A9SNF1 55
organism: Physcomitrella patens

Mitogen-activated protein kinase 4
type: ProteinReference
xref: uniprot Q39024 305
xref: PTHR24055:SF439
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 7
type: ProteinReference
xref: PTHR24055:SF401
xref: uniprot Q39027 307
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot Q39026 306
organism: Arabidopsis thaliana

MODULATION
type: RelationshipTypeVocabulary

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF378
xref: uniprot Q39021 302
organism: Arabidopsis thaliana

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q4Q0B0 308
organism: Leishmania major

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot F6TA21 983
organism: Monodelphis domestica

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q39023 304
organism: Arabidopsis thaliana

PTHR24418:SF194
type: RelationshipXref
id: PTHR24418:SF194
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 2
type: ProteinReference
xref: PTHR24055:SF196
xref: uniprot Q39022 303
organism: Arabidopsis thaliana

uniprot Q7JWT4 1171
type: UnificationXref
id: Q7JWT4
db: uniprot

00696
type: UnificationXref
id: MOD:00696
db: mod

HETERODIMER_ASSOCIATION_LEFT__CDCrel_1-_Parkin-RIGHT__Complex__CDCrel_1_Parkin_-_r68
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 1339
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 1340
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 1338
left: Parkin
left: CDCrel-1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (CDCrel-1/Parkin)

uniprot Q9HV43 243
type: UnificationXref
id: Q9HV43
db: uniprot

uniprot P60900 648
type: UnificationXref
id: P60900
db: uniprot

Discs overgrown protein kinase
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot O76324 1140
organism: Drosophila melanogaster

uniprot F0Z724 552
type: UnificationXref
id: F0Z724
db: uniprot

Physcomitrella patens
type: BioSource
xref: ncbitaxon 3218 53

uniprot Q0MQI9 952
type: UnificationXref
id: Q0MQI9
db: uniprot

uniprot Q7ZVK8 317
type: UnificationXref
id: Q7ZVK8
db: uniprot

uniprot F7BS95 992
type: UnificationXref
id: F7BS95
db: uniprot

uniprot Q656Y0 1168
type: UnificationXref
id: Q656Y0
db: uniprot

uniprot Q9FXT7 324
type: UnificationXref
id: Q9FXT7
db: uniprot

TH
type: Protein
entity reference: TH
feature: TH s110 a151 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot H2R453 785
xref: PTHR24418:SF42
organism: Pan troglodytes

Casein kinase II subunit alpha
type: ProteinReference
xref: PTHR24054:SF16
xref: uniprot P19139 907
organism: Rattus norvegicus

uniprot Q7XTE8 1070
type: UnificationXref
id: Q7XTE8
db: uniprot

uniprot Q04917 1042
type: UnificationXref
id: Q04917
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__DAT-RIGHT__DAT-_re48
control type: ACTIVATION
controller: alpha-Synuclein

PTHR24418:SF181
type: RelationshipXref
id: PTHR24418:SF181
db: PANTHER Family
relationship type: By Homology

uniprot F7BU66 993
type: UnificationXref
id: F7BU66
db: uniprot

uniprot O09061 593
type: UnificationXref
id: O09061
db: uniprot

uniprot Q9QUM9 719
type: UnificationXref
id: Q9QUM9
db: uniprot

uniprot P09446 118
type: UnificationXref
id: P09446
db: uniprot

uniprot Q7K738 478
type: UnificationXref
id: Q7K738
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6YAB9 337
xref: PTHR24055:SF110
organism: Monodelphis domestica

Putative casein kinase II
type: ProteinReference
xref: uniprot E9AEZ4 882
xref: PTHR24054:SF46
organism: Leishmania major

Casein kinase II subunit beta'
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot O96863 903
organism: Drosophila melanogaster

uniprot H2QA80 363
type: UnificationXref
id: H2QA80
db: uniprot

PARTICIPANT STOICHIOMETRY r23 1372
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

uniprot A0A1D5Q962 1095
type: UnificationXref
id: A0A1D5Q962
db: uniprot

PARTICIPANT STOICHIOMETRY r23 1374
type: Stoichiometry
physical entity: Complex (Synphilin/alpha-Synuclein)
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot H2QS62 429
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r23 1373
type: Stoichiometry
physical entity: Synphilin
stoichiometric coefficient: 1.0

Heat shock cognate 71 kDa protein
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot P19120 145
organism: Bos taurus

uniprot E2RKR4 547
type: UnificationXref
id: E2RKR4
db: uniprot

uniprot Q5ZMT0 1062
type: UnificationXref
id: Q5ZMT0
db: uniprot

uniprot P9WIV5 951
type: UnificationXref
id: P9WIV5
db: uniprot

Proteasome subunit alpha type-6-B
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot O81147 607
organism: Arabidopsis thaliana

Proteasome subunit alpha type-4-A
type: ProteinReference
xref: uniprot O81148 608
xref: PTHR11599:SF146
organism: Arabidopsis thaliana

Proteasome subunit alpha type-5-A
type: ProteinReference
xref: uniprot O81149 609
xref: PTHR11599:SF147
organism: Arabidopsis thaliana

uniprot D3ZQ41 348
type: UnificationXref
id: D3ZQ41
db: uniprot

alpha Synuclein s92 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

uniprot A8XQR9 969
type: UnificationXref
id: A8XQR9
db: uniprot

Synuclein alpha interacting protein
type: ProteinReference
xref: uniprot A0A2I3T7K0 491
xref: PTHR22882:SF3
organism: Pan troglodytes

uniprot F6XNK5 566
type: UnificationXref
id: F6XNK5
db: uniprot

uniprot A0A1D5QLV9 528
type: UnificationXref
id: A0A1D5QLV9
db: uniprot

uniprot H2R453 785
type: UnificationXref
id: H2R453
db: uniprot

Proteasome subunit beta type-3-B
type: ProteinReference
xref: uniprot O81153 610
xref: PTHR11599:SF179
organism: Arabidopsis thaliana

Hsp70, putative (Fragment)
type: ProteinReference
xref: uniprot B7PXP4 60
xref: PTHR19375:SF184
organism: Ixodes scapularis

uniprot P21242 620
type: UnificationXref
id: P21242
db: uniprot

Casein kinase I isoform gamma-2
type: ProteinReference
xref: uniprot Q8BVP5 1174
xref: PTHR11909:SF157
organism: Mus musculus

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF40
xref: uniprot F6PMD9 559
organism: Xenopus tropicalis

uniprot Q8I2X4 225
type: UnificationXref
id: Q8I2X4
db: uniprot

G01547
type: UnificationXref
id: G01547
db: PANTHER Pathway Component

alpha-Synuclein
type: Protein
entity reference: alpha-Synuclein
feature: Y125 alpha Synuclein s4 sa6 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa6 1264
feature: alpha Synuclein s4 sa6 rs4
feature: alpha Synuclein s4 sa6 rs3
feature: S129 alpha Synuclein s4 sa6 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Proteasome subunit alpha type-2
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot Q27488 659
organism: Caenorhabditis elegans

Elk-1
type: Protein
entity reference: Elk-1
feature: ACTIVE 21
feature: Elk 1 s55 a73 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Septin-5
type: ProteinReference
xref: uniprot Q99719 524
xref: PTHR18884:SF68
organism: Homo sapiens

uniprot Q6Z437 315
type: UnificationXref
id: Q6Z437
db: uniprot

uniprot F7C3R1 88
type: UnificationXref
id: F7C3R1
db: uniprot

Cyclin E
type: ProteinReference
xref: P01213
comment: ENTITY_REFERENCE_NOTES= Long Name: Cyclin E Synonym: Synonym not specified Accession: P01213
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.Cyclin E
member entity reference: G1/S-specific cyclin-E1
member entity reference: Cyclin E1
member entity reference: G1/S-specific cyclin-E2
member entity reference: Uncharacterized protein
member entity reference: CCNE2 isoform 1
member entity reference: CCNE1 isoform 1
member entity reference: Cyclin E2

uniprot O14250 594
type: UnificationXref
id: O14250
db: uniprot

ncbitaxon 5664 196
type: UnificationXref
id: 5664
db: ncbitaxon

uniprot F6ZKB3 424
type: UnificationXref
id: F6ZKB3
db: uniprot

uniprot F7A0H3 991
type: UnificationXref
id: F7A0H3
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot F6WS89 564
xref: PTHR11599:SF40
organism: Monodelphis domestica

uniprot Q8BVP5 1174
type: UnificationXref
id: Q8BVP5
db: uniprot

uniprot P09769 798
type: UnificationXref
id: P09769
db: uniprot

STATE_TRANSITION_LEFT__O2-RIGHT__ROS-_r38
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 1334
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 1335
left: O2
interaction type: STATE_TRANSITION
right: ROS

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
type: ProteinReference
xref: PTHR18860:SF16
xref: uniprot F7DGH9 994
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r72 1325
type: Stoichiometry
physical entity: DAT
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F7EI48 282
organism: Monodelphis domestica

Mitogen-activated protein kinase p38b
type: ProteinReference
xref: uniprot O61443 339
xref: PTHR24055:SF238
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r72 1326
type: Stoichiometry
physical entity: Complex (DAT/O C342)
stoichiometric coefficient: 1.0

uniprot Q9I9H1 407
type: UnificationXref
id: Q9I9H1
db: uniprot

Peripheral plasma membrane protein CASK
type: ProteinReference
xref: uniprot O14936 842
xref: PTHR23122:SF40
organism: Homo sapiens

Ubiquitin/ISG15-conjugating enzyme E2 L6
type: ProteinReference
xref: PTHR24068:SF43
xref: uniprot O14933 475
organism: Homo sapiens

Phospholipase D2
type: ProteinReference
xref: uniprot O14939 12
xref: PTHR18896:SF121
organism: Homo sapiens

NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial
type: ProteinReference
xref: uniprot P40915 950
xref: PTHR10371:SF3
organism: Neurospora crassa

Cullin-1
type: ProteinReference
xref: uniprot Q13616 1088
xref: PTHR11932:SF81
organism: Homo sapiens

uniprot A5PKG9 757
type: UnificationXref
id: A5PKG9
db: uniprot

uniprot F6UT72 562
type: UnificationXref
id: F6UT72
db: uniprot

Casein kinase I homolog HRR25
type: ProteinReference
xref: uniprot P29295 1143
xref: PTHR11909:SF18
organism: Saccharomyces cerevisiae

Uncharacterized protein
type: ProteinReference
xref: uniprot D3Z8J0 540
xref: PTHR11599:SF62
organism: Rattus norvegicus

alpha Synuclein s18 a21 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.528611247526151

TRANSPORT
type: RelationshipTypeVocabulary

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot Q7PPM9 696
xref: PTHR11599:SF14
organism: Anopheles gambiae

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 269

uniprot Q8WQM5 823
type: UnificationXref
id: Q8WQM5
db: uniprot

14-3-3-like protein GF14-F
type: ProteinReference
xref: PTHR18860:SF103
xref: uniprot Q06967 1043
organism: Oryza sativa

Predicted protein
type: ProteinReference
xref: uniprot A9TWR9 56
xref: PTHR19375:SF395
organism: Physcomitrella patens

Complex (19S proteasome/alpha-Synuclein)
type: Complex
component stoichiometry: alpha Synuclein s29 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: 19S proteasome s25 sa3 STOICHIOMETRY ID COMPLEX
component: alpha-Synuclein
component: 19S proteasome
feature: COMPLEX BINDING FEATURE s32 a42 1211
feature: COMPLEX BINDING FEATURE s32 a42 1213
cellular location: intracellular

Dopamine transporter
type: DnaRegionReference
member entity reference: Sodium-dependent dopamine transporter
member entity reference: Transporter
xref: G01547
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.GENE.GENE.DAT
comment: ENTITY_REFERENCE_NOTES= Long Name: Dopamine transporter Synonym: Synonym not specified Accession: G01547
display name: DAT

CASK
type: Protein
entity reference: CASK
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F6R812 1127
type: UnificationXref
id: F6R812
db: uniprot

uniprot Q09682 651
type: UnificationXref
id: Q09682
db: uniprot

uniprot Q93Z18 1185
type: UnificationXref
id: Q93Z18
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__TH-_Parkin-RIGHT__Complex__TH_Parkin_-_r60
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 1354
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 1353
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 1352
left: Parkin
left: TH
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TH/Parkin)

alpha Synuclein s18 a21 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Sodium-dependent dopamine transporter
type: DnaReference
xref: PTHR11616:SF38
organism: Rattus norvegicus

Tyrosine-protein kinase Src64B
type: ProteinReference
xref: PTHR24418:SF194
xref: uniprot P00528 788
organism: Drosophila melanogaster

uniprot Q384W9 665
type: UnificationXref
id: Q384W9
db: uniprot

Casein kinase II subunit beta
type: ProteinReference
xref: uniprot Q967X2 942
xref: PTHR11740:SF0
organism: Ciona intestinalis

Heat shock protein 70
type: ProteinReference
xref: uniprot Q8I2X4 225
xref: PTHR19375:SF144
organism: Plasmodium falciparum

uniprot H2Q482 857
type: UnificationXref
id: H2Q482
db: uniprot

Proto-oncogene tyrosine-protein kinase Src
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot P00523 787
organism: Gallus gallus

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot Q6H852 687
organism: Oryza sativa

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 8

Casein kinase II subunit beta
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot B7QIS2 878
organism: Ixodes scapularis

uniprot O62102 605
type: UnificationXref
id: O62102
db: uniprot

UbcH8
type: Protein
entity reference: UbcH8
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Parkin
type: Protein
entity reference: Parkin
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

alpha Synuclein s87 sa25 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.528611247526151

Ubiquitin-conjugating enzyme E2-18 kDa
type: ProteinReference
xref: uniprot P52487 476
organism: Drosophila melanogaster

uniprot P41797 165
type: UnificationXref
id: P41797
db: uniprot

uniprot Q9WXM7 961
type: UnificationXref
id: Q9WXM7
db: uniprot

14-3-3-like protein GF14-E
type: ProteinReference
xref: PTHR12874:SF9
xref: uniprot Q6EUP4 1063
organism: Oryza sativa

uniprot Q86Y82 386
type: UnificationXref
id: Q86Y82
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot Q7SXN6 702
xref: PTHR11599:SF110
organism: Danio rerio

uniprot P48348 1021
type: UnificationXref
id: P48348
db: uniprot

uniprot Q8T0Y8 706
type: UnificationXref
id: Q8T0Y8
db: uniprot

uniprot Q9NHE2 1196
type: UnificationXref
id: Q9NHE2
db: uniprot

STIP1 homology and U-box containing protein 1
type: ProteinReference
xref: PTHR46803:SF2
xref: uniprot H2QA80 363
organism: Pan troglodytes

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 83

Probable 26S proteasome regulatory subunit rpn9
type: ProteinReference
xref: uniprot Q9US13 257
xref: PTHR10539:SF0
organism: Schizosaccharomyces pombe

alpha Synuclein s87 sa25 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot Q20719 953
type: UnificationXref
id: Q20719
db: uniprot

uniprot A7MAZ2 367
type: UnificationXref
id: A7MAZ2
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot F7FWN9 777
organism: Macaca mulatta

uniprot P25786 628
type: UnificationXref
id: P25786
db: uniprot

PTHR11616:SF38
type: RelationshipXref
id: PTHR11616:SF38
db: PANTHER Family
relationship type: By Homology

uniprot P61982 1025
type: UnificationXref
id: P61982
db: uniprot

uniprot A0A0G2JVE0 1093
type: UnificationXref
id: A0A0G2JVE0
db: uniprot

a148_degraded
type: PhysicalEntity
cellular location: intracellular
comment: SPECIES_TYPE=DEGRADED

uniprot Q5A1D3 310
type: UnificationXref
id: Q5A1D3
db: uniprot

Proteasome subunit alpha type-4-2
type: ProteinReference
xref: uniprot Q5VRG3 681
xref: PTHR11599:SF13
organism: Oryza sativa

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot Q7PPI7 695
xref: PTHR11599:SF13
organism: Anopheles gambiae

Proteasome subunit alpha type (Fragment)
type: ProteinReference
xref: uniprot F0ZNQ2 553
xref: PTHR11599:SF15
organism: Dictyostelium purpureum

Gamma-synuclein
type: ProteinReference
xref: uniprot Q63544 832
organism: Rattus norvegicus

uniprot Q09639 865
type: UnificationXref
id: Q09639
db: uniprot

PTHR10539:SF0
type: RelationshipXref
id: PTHR10539:SF0
db: PANTHER Family
relationship type: By Homology

uniprot A9S0A3 54
type: UnificationXref
id: A9S0A3
db: uniprot

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
type: ProteinReference
xref: uniprot Q0MQI9 952
xref: PTHR10371:SF3
organism: Pan troglodytes

uniprot F1PKW7 981
type: UnificationXref
id: F1PKW7
db: uniprot

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: uniprot P78695 174
xref: PTHR19375:SF144
organism: Neurospora crassa

HETERODIMER_ASSOCIATION_LEFT__alpha_Synuclein-_Synphilin-RIGHT__Complex__Synphilin_alpha_Synuclein_-_r23
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1372
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1373
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1374
left: Synphilin
left: alpha-Synuclein
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Synphilin/alpha-Synuclein)

ncbitaxon 188937 234
type: UnificationXref
id: 188937
db: ncbitaxon

F-box/WD repeat-containing protein 7
type: ProteinReference
xref: uniprot D3Z902 1098
organism: Rattus norvegicus

CDCrel 1 s117 a168 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A0A0D1C4Y4 263
type: UnificationXref
id: A0A0D1C4Y4
db: uniprot

Heat shock protein/chaperone
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot B8BWB9 62
organism: Thalassiosira pseudonana

uniprot Q8R1J9 460
type: UnificationXref
id: Q8R1J9
db: uniprot

uniprot Q28F65 831
type: UnificationXref
id: Q28F65
db: uniprot

Mediator of RNA polymerase II transcription subunit 37f
type: ProteinReference
xref: uniprot Q39043 193
xref: PTHR19375:SF144
organism: Arabidopsis thaliana

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 180

14-3-3 protein homolog
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot O42766 1006
organism: Candida albicans

CDCrel 1 s107 sa38 rs1
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F6UKV3 1083
type: UnificationXref
id: F6UKV3
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot E2QVP6 975
organism: Canis lupus familiaris

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 120

uniprot Q9XYN7 731
type: UnificationXref
id: Q9XYN7
db: uniprot

Ubiquitin-conjugating enzyme E2L 3a
type: ProteinReference
xref: uniprot A0A2R8QI56 482
organism: Danio rerio

Heat shock 70 kDa protein 9, mitochondrial
type: ProteinReference
xref: PTHR19375:SF397
xref: uniprot Q8GUM2 223
organism: Arabidopsis thaliana

uniprot P0AFD1 947
type: UnificationXref
id: P0AFD1
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot Q63538 441
xref: PTHR24055:SF146
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r44
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 1316
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 1315
left: alpha-Synuclein
interaction type: STATE_TRANSITION
right: alpha-Synuclein

STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r45
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 1310
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 1309
left: alpha-Synuclein
interaction type: STATE_TRANSITION
right: alpha-Synuclein

uniprot A9U4N3 57
type: UnificationXref
id: A9U4N3
db: uniprot

uniprot Q84J55 1072
type: UnificationXref
id: Q84J55
db: uniprot

Heat shock protein 5
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot Q6P3L3 213
organism: Danio rerio

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 264

Complex (Synphilin/alpha-Synuclein)
type: Complex
component stoichiometry: alpha Synuclein s4 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: Synphilin s3 sa5 STOICHIOMETRY ID COMPLEX
component: alpha-Synuclein
component: Synphilin
feature: COMPLEX BINDING FEATURE s35 a50 1261
feature: COMPLEX BINDING FEATURE s35 a50 1263
cellular location: intracellular

uniprot P67868 918
type: UnificationXref
id: P67868
db: uniprot

Casein kinase 1-like protein 13
type: ProteinReference
xref: uniprot Q5XF24 1163
xref: PTHR11909:SF355
organism: Arabidopsis thaliana

Tyrosine-protein kinase Fgr
type: ProteinReference
xref: PTHR24418:SF224
xref: uniprot P14234 800
organism: Mus musculus

Proteasome subunit alpha type-4-like
type: ProteinReference
xref: uniprot Q9VA12 726
xref: PTHR11599:SF13
organism: Drosophila melanogaster

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot A0A0D1C4Y4 263
organism: Ustilago maydis

uniprot Q4KM35 674
type: UnificationXref
id: Q4KM35
db: uniprot

uniprot Q8LPJ1 1179
type: UnificationXref
id: Q8LPJ1
db: uniprot

Casein kinase I isoform delta-B
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot Q6P3K7 1169
organism: Danio rerio

uniprot F7DXH6 775
type: UnificationXref
id: F7DXH6
db: uniprot

uniprot H2QVB0 743
type: UnificationXref
id: H2QVB0
db: uniprot

uniprot Q3ZBG0 672
type: UnificationXref
id: Q3ZBG0
db: uniprot

Transporter
type: ProteinReference
xref: PTHR11616:SF38
xref: uniprot F7CT33 736
organism: Macaca mulatta

Proteasome subunit beta
type: ProteinReference
xref: PTHR11599:SF44
xref: uniprot Q9W470 730
organism: Drosophila melanogaster

G-protein coupled receptor 37-like 1
type: ProteinReference
xref: uniprot Q99JG2 746
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r52 1388
type: Stoichiometry
physical entity: Cyclin E
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r52 1389
type: Stoichiometry
physical entity: a119_degraded
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 1365
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 1364
left: alpha-Synuclein
interaction type: STATE_TRANSITION
right: alpha-Synuclein

STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r27
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 1360
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 1361
left: alpha-Synuclein
interaction type: STATE_TRANSITION
right: alpha-Synuclein

ncbitaxon 8364 51
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot Q10Q71 924
type: UnificationXref
id: Q10Q71
db: uniprot

uniprot Q9Z2U0 734
type: UnificationXref
id: Q9Z2U0
db: uniprot

Parkin s46 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

STIP1 homology and U-box containing protein 1
type: ProteinReference
xref: PTHR46803:SF2
xref: uniprot F6YL96 361
organism: Monodelphis domestica

Proteasome subunit alpha type-1
type: ProteinReference
xref: uniprot P18420 616
xref: PTHR11599:SF12
organism: Rattus norvegicus

Proteasome subunit beta type-1
type: ProteinReference
xref: uniprot P18421 617
xref: PTHR11599:SF59
organism: Rattus norvegicus

Proteasome subunit alpha type-3
type: ProteinReference
xref: PTHR11599:SF10
xref: uniprot P18422 618
organism: Rattus norvegicus

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 16

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF245
xref: uniprot F7H8A7 782
organism: Macaca mulatta

uniprot F7G2C9 778
type: UnificationXref
id: F7G2C9
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

INHIBITION
type: RelationshipTypeVocabulary

uniprot A0A1D5QQB8 481
type: UnificationXref
id: A0A1D5QQB8
db: uniprot

Torsin A
type: ProteinReference
xref: P01221
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.Torsin A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Torsin A Synonym: Synonym not specified Accession: P01221
member entity reference: Torsin
member entity reference: Torsin-2A
member entity reference: Torsin family 1 member A
member entity reference: Torsin-1A
member entity reference: Uncharacterized protein

uniprot F6YDY3 568
type: UnificationXref
id: F6YDY3
db: uniprot

STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 1356
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 1355
left: alpha-Synuclein
interaction type: STATE_TRANSITION
right: alpha-Synuclein

uniprot Q1LWY1 656
type: UnificationXref
id: Q1LWY1
db: uniprot

NuoE, NADH dehydrogenase subunit
type: ProteinReference
xref: uniprot Q9XAQ8 962
organism: Streptomyces coelicolor

uniprot Q8C4X2 1175
type: UnificationXref
id: Q8C4X2
db: uniprot

ncbitaxon 189518 170
type: UnificationXref
id: 189518
db: ncbitaxon

uniprot E1BD83 543
type: UnificationXref
id: E1BD83
db: uniprot

alpha-Synuclein
type: Protein
entity reference: alpha-Synuclein
feature: Y125 alpha Synuclein s95 sa30 rs2
feature: alpha Synuclein s95 sa30 rs4
feature: COMPLEX PARTICIPANT BINDING FEATURE s95 sa30 1232
feature: S129 alpha Synuclein s95 sa30 rs1
feature: alpha Synuclein s95 sa30 rs3
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

O-glyc
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s91 sa26 1224
cellular location: intracellular
comment: SPECIES_TYPE=ION

uniprot F6S4U9 77
type: UnificationXref
id: F6S4U9
db: uniprot

uniprot F1RDG9 766
type: UnificationXref
id: F1RDG9
db: uniprot

uniprot Q38CK9 667
type: UnificationXref
id: Q38CK9
db: uniprot

uniprot Q9UT97 724
type: UnificationXref
id: Q9UT97
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__CDCrel_1_Parkin_-RIGHT__a173_degraded-_r70
controller: Complex (19S proteasome/20S proteasome)

Heat shock protein 70-related protein
type: ProteinReference
xref: uniprot Q4Q970 202
xref: PTHR19375:SF254
organism: Leishmania major

uniprot A0A1D5NXE7 1094
type: UnificationXref
id: A0A1D5NXE7
db: uniprot

CDCrel-1
type: ProteinReference
xref: P01226
standard name: Cell division cycle-related protein 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Cell division cycle-related protein 1 Synonym: Synonym not specified Accession: P01226
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.CDCrel-1
member entity reference: Septin-2
member entity reference: Septin 2
member entity reference: Septin-5
member entity reference: Uncharacterized protein
member entity reference: Septin-1
member entity reference: SEPT2 isoform 11
member entity reference: SEPT5 isoform 5
member entity reference: Septin 4
member entity reference: Septin-4
member entity reference: AGAP002645-PA
member entity reference: Septin 4, isoform A
member entity reference: Septin-2B
member entity reference: Septin 5
member entity reference: SEPT1 isoform 3

uniprot Q9C7X7 240
type: UnificationXref
id: Q9C7X7
db: uniprot

uniprot Q4QC00 675
type: UnificationXref
id: Q4QC00
db: uniprot

Beta-adrenergic receptor kinase 2
type: ProteinReference
xref: PTHR24355:SF17
xref: uniprot P26818 862
organism: Bos taurus

uniprot Q00981 261
type: UnificationXref
id: Q00981
db: uniprot

Beta-adrenergic receptor kinase 1
type: ProteinReference
xref: PTHR24355:SF22
xref: uniprot P26817 861
organism: Rattus norvegicus

uniprot Q13616 1088
type: UnificationXref
id: Q13616
db: uniprot

Heat shock protein SSA2
type: ProteinReference
xref: PTHR19375:SF426
xref: uniprot P10592 128
organism: Saccharomyces cerevisiae

ncbitaxon 224324 112
type: UnificationXref
id: 224324
db: ncbitaxon

Heat shock protein SSA1
type: ProteinReference
xref: PTHR19375:SF426
xref: uniprot P10591 127
organism: Saccharomyces cerevisiae

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot Q05876 812
organism: Gallus gallus

uniprot P67874 921
type: UnificationXref
id: P67874
db: uniprot

Proteasome subunit alpha type-2
type: ProteinReference
xref: PTHR11599:SF137
xref: uniprot Q10KF0 655
organism: Oryza sativa

Proteasome endopeptidase complex
type: ProteinReference
xref: uniprot D6XCY8 541
xref: PTHR11599:SF10
organism: Trypanosoma brucei

uniprot Q8GUM2 223
type: UnificationXref
id: Q8GUM2
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__L_tyrosine-RIGHT__L_DOPA-_r61
control type: INHIBITION
controller: alpha-Synuclein

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Synphilin_Parkin_-RIGHT__a92_degraded-_r42
controller: Complex (19S proteasome/20S proteasome)

uniprot P39688 804
type: UnificationXref
id: P39688
db: uniprot

Proteasome subunit alpha type-1
type: ProteinReference
xref: PTHR11599:SF12
xref: uniprot P25786 628
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BS95 992
xref: PTHR18860:SF7
organism: Monodelphis domestica

Proteasome subunit alpha type-3
type: ProteinReference
xref: PTHR11599:SF10
xref: uniprot P25788 630
organism: Homo sapiens

Proteasome subunit alpha type-2
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot P25787 629
organism: Homo sapiens

Proteasome subunit alpha type-4
type: ProteinReference
xref: uniprot P25789 631
xref: PTHR11599:SF13
organism: Homo sapiens

Y125 alpha Synuclein s4 sa6 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y125
feature location: Y125 alpha Synuclein s4 sa6 rs2 Y125
comment: MODIFICATION_RESIDUE_NAME=Y125
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.69

Y125 alpha Synuclein s92 sa27 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y125
feature location: Y125 alpha Synuclein s92 sa27 rs2 Y125
comment: MODIFICATION_RESIDUE_NAME=Y125
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.69

Synphilin
type: ProteinReference
xref: P01225
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.Synphilin
comment: ENTITY_REFERENCE_NOTES= Long Name: Synphilin Synonym: Synonym not specified Accession: P01225
member entity reference: Uncharacterized protein
member entity reference: Synuclein alpha interacting protein
member entity reference: Synphilin-1
member entity reference: Synuclein, alpha interacting protein (Synphilin) (Predicted), isoform CRA_a

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
type: ProteinReference
xref: PTHR18860:SF16
xref: uniprot J9P6N4 1005
organism: Canis lupus familiaris

a109_degraded
type: PhysicalEntity
cellular location: intracellular
comment: SPECIES_TYPE=DEGRADED

ncbitaxon 243230 250
type: UnificationXref
id: 243230
db: ncbitaxon

Proteasome subunit alpha type-1
type: ProteinReference
xref: uniprot P52428 647
xref: PTHR11599:SF12
organism: Oryza sativa

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__DAT-RIGHT__Complex__DAT_O_C342_-_r72
control type: ACTIVATION
controller: ONOO-

uniprot H2Q7D5 487
type: UnificationXref
id: H2Q7D5
db: uniprot

14-3-3 protein 2
type: ProteinReference
xref: uniprot C4LXB1 972
xref: PTHR18860:SF106
organism: Entamoeba histolytica

Proteasome endopeptidase complex
type: ProteinReference
xref: uniprot A0A1D5QEC6 526
xref: PTHR11599:SF14
organism: Macaca mulatta

STX12 protein
type: ProteinReference
xref: PTHR19957:SF88
xref: uniprot A7MAZ2 367
organism: Bos taurus

Parkin
type: Protein
entity reference: Parkin
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa13 1270
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

PTHR24418:SF224
type: RelationshipXref
id: PTHR24418:SF224
db: PANTHER Family
relationship type: By Homology

S129 alpha Synuclein s95 sa30 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S129
feature location: S129 alpha Synuclein s95 sa30 rs1 S129
comment: MODIFICATION_RESIDUE_NAME=S129
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

Parkin
type: Protein
entity reference: Parkin
feature: COMPLEX PARTICIPANT BINDING FEATURE s85 sa23 1206
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q8WQ99 1184
type: UnificationXref
id: Q8WQ99
db: uniprot

Proteasome subunit alpha type-5
type: ProteinReference
xref: uniprot Q9Z2U1 735
xref: PTHR11599:SF14
organism: Mus musculus

Proteasome subunit alpha type-7
type: ProteinReference
xref: uniprot Q9Z2U0 734
xref: PTHR11599:SF40
organism: Mus musculus

PTHR11599:SF183
type: RelationshipXref
id: PTHR11599:SF183
db: PANTHER Family
relationship type: By Homology

uniprot F6XFG9 987
type: UnificationXref
id: F6XFG9
db: uniprot

uniprot F7FWN9 777
type: UnificationXref
id: F7FWN9
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Parkin-_CASK-RIGHT__Complex__CASK_Parkin_-_r54
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 1378
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 1379
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 1377
left: CASK
left: Parkin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (CASK/Parkin)

Proteasome subunit alpha type-3
type: ProteinReference
xref: uniprot Q9V5C6 725
xref: PTHR11599:SF10
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r38 1335
type: Stoichiometry
physical entity: ROS
stoichiometric coefficient: 1.0

PTHR11599:SF174
type: RelationshipXref
id: PTHR11599:SF174
db: PANTHER Family
relationship type: By Homology

Heat shock 70 kDa protein 6
type: ProteinReference
xref: PTHR19375:SF168
xref: uniprot P17066 138
organism: Homo sapiens

PTHR46216:SF3
type: RelationshipXref
id: PTHR46216:SF3
db: PANTHER Family
relationship type: By Homology

Calcium/calmodulin-dependent serine protein kinase (MAGUK family)
type: ProteinReference
xref: PTHR23122:SF40
xref: uniprot F6UGQ3 839
organism: Xenopus tropicalis

uniprot Q95UJ1 850
type: UnificationXref
id: Q95UJ1
db: uniprot

uniprot P17289 1111
type: UnificationXref
id: P17289
db: uniprot

PARTICIPANT STOICHIOMETRY r38 1334
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

uniprot P73098 173
type: UnificationXref
id: P73098
db: uniprot

Pael R s38 sa14 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P82910 176
type: UnificationXref
id: P82910
db: uniprot

PTHR24418:SF245
type: RelationshipXref
id: PTHR24418:SF245
db: PANTHER Family
relationship type: By Homology

Cullin 1
type: ProteinReference
xref: PTHR11932:SF81
xref: uniprot F6X2V7 1084
organism: Ornithorhynchus anatinus

uniprot Q9WYK6 253
type: UnificationXref
id: Q9WYK6
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot A8WS54 531
xref: PTHR11599:SF14
organism: Caenorhabditis briggsae

uniprot A2E9W8 30
type: UnificationXref
id: A2E9W8
db: uniprot

PTHR11599:SF179
type: RelationshipXref
id: PTHR11599:SF179
db: PANTHER Family
relationship type: By Homology

PTHR10760:SF4
type: RelationshipXref
id: PTHR10760:SF4
db: PANTHER Family
relationship type: By Homology

uniprot A0A3Q1LTT9 335
type: UnificationXref
id: A0A3Q1LTT9
db: uniprot

F-box/WD repeat-containing protein 11
type: ProteinReference
xref: uniprot Q9UKB1 1106
organism: Homo sapiens

CUL1 isoform 1
type: ProteinReference
xref: PTHR11932:SF81
xref: uniprot G2HEC7 1085
organism: Pan troglodytes

HETERODIMER_ASSOCIATION_LEFT__14_3_3-_alpha_Synuclein-RIGHT__Complex__14_3_3_alpha_Synuclein_-_r31
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 1346
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 1345
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 1347
left: 14-3-3
left: alpha-Synuclein
interaction type: HETERODIMER_ASSOCIATION
right: Complex (14-3-3/alpha-Synuclein)

Predicted protein
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot A9RCV9 52
organism: Physcomitrella patens

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot A0A1D5QL29 527
xref: PTHR11599:SF11
organism: Macaca mulatta

uniprot H2Q9W6 583
type: UnificationXref
id: H2Q9W6
db: uniprot

uniprot P63017 171
type: UnificationXref
id: P63017
db: uniprot

TRANSLATION
type: RelationshipTypeVocabulary

PTHR10760:SF2
type: RelationshipXref
id: PTHR10760:SF2
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Complex__O_glyc_alpha_Synuclein__Parkin_-_Ub-RIGHT__Complex__O_glyc_alpha_Synuclein__Parkin_-_r56
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 1369
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 1370
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 1371
left: Ub
left: Complex (O-glyc/alpha-Synuclein/ Parkin)
interaction type: STATE_TRANSITION
right: Complex (O-glyc/alpha-Synuclein/ Parkin)

uniprot A8XPD5 473
type: UnificationXref
id: A8XPD5
db: uniprot

uniprot O14933 475
type: UnificationXref
id: O14933
db: uniprot

YALI0D16863p
type: ProteinReference
xref: PTHR24054:SF0
xref: uniprot Q6C8U8 929
organism: Yarrowia lipolytica

uniprot Q9WUD9 827
type: UnificationXref
id: Q9WUD9
db: uniprot

Proteasome subunit alpha type-6
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot Q9QUM9 719
organism: Mus musculus

uniprot F7FPX9 1132
type: UnificationXref
id: F7FPX9
db: uniprot

Casein kinase 1-like protein 12
type: ProteinReference
xref: uniprot Q8VYK9 1182
xref: PTHR11909:SF367
organism: Arabidopsis thaliana

uniprot F0ZYX2 554
type: UnificationXref
id: F0ZYX2
db: uniprot

Septin-5
type: ProteinReference
xref: PTHR18884:SF68
xref: uniprot Q9Z2Q6 525
organism: Mus musculus

Ubiquitin conjugating enzyme E2 L5
type: ProteinReference
xref: uniprot F7EVY1 486
xref: PTHR24068:SF170
organism: Macaca mulatta

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: PTHR19375:SF380
xref: uniprot P11021 129
organism: Homo sapiens

uniprot A0A3Q1MXU1 498
type: UnificationXref
id: A0A3Q1MXU1
db: uniprot

ncbitaxon 243274 254
type: UnificationXref
id: 243274
db: ncbitaxon

PTHR11599:SF146
type: RelationshipXref
id: PTHR11599:SF146
db: PANTHER Family
relationship type: By Homology

uniprot A7MB57 758
type: UnificationXref
id: A7MB57
db: uniprot

Tyrosine 3-monooxygenase
type: ProteinReference
xref: uniprot P24529 1112
xref: PTHR11473:SF18
organism: Mus musculus

PTHR11599:SF144
type: RelationshipXref
id: PTHR11599:SF144
db: PANTHER Family
relationship type: By Homology

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot F6XW91 989
organism: Ornithorhynchus anatinus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex_I-RIGHT__Complex_I-_r7
controller: MPP+

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__19S_proteasome_20S_proteasome_-RIGHT__20S_proteasome-_19S_proteasome-_r21
controller: alpha-Synuclein

uniprot F6XFE0 85
type: UnificationXref
id: F6XFE0
db: uniprot

O glyc s94 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: O-glyc
stoichiometric coefficient: 1.0

PTHR11599:SF147
type: RelationshipXref
id: PTHR11599:SF147
db: PANTHER Family
relationship type: By Homology

uniprot Q9VNA5 728
type: UnificationXref
id: Q9VNA5
db: uniprot

uniprot D3YUM8 539
type: UnificationXref
id: D3YUM8
db: uniprot

ncbitaxon 224308 141
type: UnificationXref
id: 224308
db: ncbitaxon

PTHR11932:SF156
type: RelationshipXref
id: PTHR11932:SF156
db: PANTHER Family
relationship type: By Homology

Stratifin
type: ProteinReference
xref: PTHR18860:SF14
xref: uniprot F7BU66 993
organism: Ornithorhynchus anatinus

uniprot Q20655 1045
type: UnificationXref
id: Q20655
db: uniprot

ncbitaxon 36329 226
type: UnificationXref
id: 36329
db: ncbitaxon

PTHR11599:SF137
type: RelationshipXref
id: PTHR11599:SF137
db: PANTHER Family
relationship type: By Homology

uniprot Q9ER39 461
type: UnificationXref
id: Q9ER39
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FGS3 1100
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot E9GCV0 883
xref: PTHR24054:SF0
organism: Daphnia pulex

CDCrel 1 s128 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CDCrel-1
stoichiometric coefficient: 1.0

G1/S-specific cyclin-E2
type: ProteinReference
xref: PTHR10177:SF70
xref: uniprot O96020 353
organism: Homo sapiens

DNA helicase
type: ProteinReference
xref: uniprot F1QK71 73
organism: Danio rerio

uniprot Q4Q7Y4 200
type: UnificationXref
id: Q4Q7Y4
db: uniprot

uniprot P24529 1112
type: UnificationXref
id: P24529
db: uniprot

uniprot A0A2J8N1X7 24
type: UnificationXref
id: A0A2J8N1X7
db: uniprot

G protein-coupled receptor kinase
type: ProteinReference
xref: uniprot A0A2R8QPB8 852
xref: PTHR24355:SF18
organism: Danio rerio

uniprot Q9D6J6 955
type: UnificationXref
id: Q9D6J6
db: uniprot

uniprot Q9LTX9 248
type: UnificationXref
id: Q9LTX9
db: uniprot

uniprot Q9S9Z8 1075
type: UnificationXref
id: Q9S9Z8
db: uniprot

ncbitaxon 284812 108
type: UnificationXref
id: 284812
db: ncbitaxon

N Y125
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s76 sa20 1208
cellular location: intracellular
comment: SPECIES_TYPE=ION

FI08417p
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot Q9VJC2 1198
organism: Drosophila melanogaster

Parkin
type: Protein
entity reference: Parkin
feature: COMPLEX PARTICIPANT BINDING FEATURE s43 sa15 1274
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Protein CBR-SYX-7
type: ProteinReference
xref: uniprot A8XFD7 368
organism: Caenorhabditis briggsae

uniprot Q27488 659
type: UnificationXref
id: Q27488
db: uniprot

uniprot Q9RU91 957
type: UnificationXref
id: Q9RU91
db: uniprot

uniprot Q5ZLI2 682
type: UnificationXref
id: Q5ZLI2
db: uniprot

PARTICIPANT STOICHIOMETRY r58 1363
type: Stoichiometry
physical entity: a148_degraded
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 1362
type: Stoichiometry
physical entity: Complex (O-glyc/alpha-Synuclein/ Parkin)
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q5SN53 311
organism: Oryza sativa

Casein kinase II
type: Protein
entity reference: Casein kinase II
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q7PY13 697
type: UnificationXref
id: Q7PY13
db: uniprot

DA
type: SmallMolecule
cellular location: intracellular
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Putative casein kinase I
type: ProteinReference
xref: PTHR11909:SF406
xref: uniprot O96999 1141
organism: Leishmania major

UBiquitin Conjugating enzyme
type: ProteinReference
xref: uniprot Q21633 477
organism: Caenorhabditis elegans

uniprot Q5E987 680
type: UnificationXref
id: Q5E987
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7E823 280
organism: Monodelphis domestica

uniprot F7B4P4 741
type: UnificationXref
id: F7B4P4
db: uniprot

uniprot P40150 164
type: UnificationXref
id: P40150
db: uniprot

Proteasome subunit beta
type: ProteinReference
xref: PTHR11599:SF62
xref: uniprot E2QX17 545
organism: Canis lupus familiaris

uniprot D3Z8J0 540
type: UnificationXref
id: D3Z8J0
db: uniprot

uniprot P22202 148
type: UnificationXref
id: P22202
db: uniprot

uniprot A8XFM4 536
type: UnificationXref
id: A8XFM4
db: uniprot

14-3-3 protein beta/alpha-A
type: ProteinReference
xref: PTHR18860:SF28
xref: uniprot Q5PRD0 1055
organism: Danio rerio

O glyc s86 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: O-glyc
stoichiometric coefficient: 1.0

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 68

STATE_TRANSITION_LEFT__MPTP-RIGHT__MPP_PLUS_-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 1308
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 1307
left: MPTP
interaction type: STATE_TRANSITION
right: MPP+

PARTICIPANT STOICHIOMETRY r12 1313
type: Stoichiometry
physical entity: PLD2
stoichiometric coefficient: 1.0

Heat shock 70 kDa protein BIP1
type: ProteinReference
xref: uniprot Q6Z7B0 216
xref: PTHR19375:SF144
organism: Oryza sativa

PARTICIPANT STOICHIOMETRY r12 1314
type: Stoichiometry
physical entity: PLD2
stoichiometric coefficient: 1.0

Heat shock cognate 71 kDa protein
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot A0A1D5PFJ6 22
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r59 1357
type: Stoichiometry
physical entity: Complex (TH/Parkin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 1359
type: Stoichiometry
physical entity: Complex (TH/Parkin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 1358
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

G protein-coupled receptor kinase 2
type: ProteinReference
xref: uniprot Q09639 865
xref: PTHR24355:SF18
organism: Caenorhabditis elegans

Heat shock protein family A (Hsp70) member 1A
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot F6TJ80 79
organism: Xenopus tropicalis

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot F6WR53 771
organism: Monodelphis domestica

uniprot P28482 294
type: UnificationXref
id: P28482
db: uniprot

uniprot Q7PQK5 220
type: UnificationXref
id: Q7PQK5
db: uniprot

uniprot Q7Q6A2 470
type: UnificationXref
id: Q7Q6A2
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7EH19 281
organism: Xenopus tropicalis

Proteasome subunit beta
type: ProteinReference
xref: uniprot Q6H800 686
xref: PTHR11599:SF62
organism: Oryza sativa

Ubiquitin-conjugating enzyme E2 L3
type: ProteinReference
xref: uniprot F6W7B6 484
organism: Xenopus tropicalis

uniprot F6XAZ1 565
type: UnificationXref
id: F6XAZ1
db: uniprot

Chaperone protein DnaK
type: ProteinReference
xref: uniprot Q9HV43 243
xref: PTHR19375:SF184
organism: Pseudomonas aeruginosa

uniprot P49187 435
type: UnificationXref
id: P49187
db: uniprot

uniprot Q7PFH8 219
type: UnificationXref
id: Q7PFH8
db: uniprot

Y125 alpha Synuclein s49 a69 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y125
feature location: Y125 alpha Synuclein s49 a69 rs2 Y125
comment: MODIFICATION_RESIDUE_NAME=Y125
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.69

uniprot P0CB32 121
type: UnificationXref
id: P0CB32
db: uniprot

Putative G-protein coupled receptor 37
type: ProteinReference
xref: PTHR46216:SF3
xref: uniprot F7B4P4 741
organism: Macaca mulatta

uniprot O97125 113
type: UnificationXref
id: O97125
db: uniprot

uniprot F6R8N9 278
type: UnificationXref
id: F6R8N9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r45
controller: Fyn kinase

Septin 2
type: ProteinReference
xref: uniprot F6YUL8 505
organism: Monodelphis domestica

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P70618 342
xref: PTHR24055:SF110
organism: Rattus norvegicus

Parkin s43 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

Cul-1
type: Protein
entity reference: Cul-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa17 1248
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Probable proteasome subunit alpha type-3
type: ProteinReference
xref: PTHR11599:SF13
xref: uniprot Q09682 651
organism: Schizosaccharomyces pombe

uniprot P11146 132
type: UnificationXref
id: P11146
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E2RSH8 763
xref: PTHR24418:SF53
organism: Canis lupus familiaris

uniprot E2QX25 1122
type: UnificationXref
id: E2QX25
db: uniprot

Protein kinase family protein
type: ProteinReference
xref: uniprot Q9SQR8 1197
xref: PTHR11909:SF353
organism: Arabidopsis thaliana

Tyrosine-protein kinase Fgr
type: ProteinReference
xref: uniprot P09769 798
xref: PTHR24418:SF224
organism: Homo sapiens

alpha-Synuclein
type: Protein
entity reference: alpha-Synuclein
feature: S129 alpha Synuclein s13 sa8 rs1
feature: alpha Synuclein s13 sa8 rs4
feature: alpha Synuclein s13 sa8 rs3
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa8 1268
feature: Y125 alpha Synuclein s13 sa8 rs2
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot O24616 600
type: UnificationXref
id: O24616
db: uniprot

Casein kinase 1-like protein 5
type: ProteinReference
xref: uniprot Q9ZUP4 1202
xref: PTHR11909:SF356
organism: Arabidopsis thaliana

uniprot P0C865 288
type: UnificationXref
id: P0C865
db: uniprot

uniprot Q5F3W6 1052
type: UnificationXref
id: Q5F3W6
db: uniprot

STATE_TRANSITION_LEFT__Complex__TH_Parkin_-_Ub-RIGHT__Complex__TH_Parkin_-_r59
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 1359
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 1357
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 1358
left: Ub
left: Complex (TH/Parkin)
interaction type: STATE_TRANSITION
right: Complex (TH/Parkin)

uniprot Q7PPM9 696
type: UnificationXref
id: Q7PPM9
db: uniprot

Casein kinase II subunit beta-3
type: ProteinReference
xref: uniprot O81275 901
xref: PTHR11740:SF22
organism: Arabidopsis thaliana

Probable proteasome subunit alpha type-7
type: ProteinReference
xref: uniprot P21242 620
xref: PTHR11599:SF10
organism: Saccharomyces cerevisiae

uniprot P25787 629
type: UnificationXref
id: P25787
db: uniprot

Proteasome subunit alpha type-1
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot P21243 621
organism: Saccharomyces cerevisiae

S129 alpha Synuclein s49 a69 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S129
feature location: S129 alpha Synuclein s49 a69 rs1 S129
comment: MODIFICATION_RESIDUE_NAME=S129
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

uniprot Q9VA12 726
type: UnificationXref
id: Q9VA12
db: uniprot

Beta-synuclein
type: ProteinReference
xref: uniprot Q91ZZ3 400
xref: PTHR13820:SF4
organism: Mus musculus

Casein kinase II subunit beta-1
type: ProteinReference
xref: uniprot Q8TG12 938
xref: PTHR11740:SF24
organism: Neurospora crassa

Casein kinase II subunit alpha
type: ProteinReference
xref: PTHR24054:SF0
xref: uniprot Q8TG13 939
organism: Neurospora crassa

Parkin
type: Protein
entity reference: Parkin
feature: COMPLEX PARTICIPANT BINDING FEATURE s104 sa35 1246
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Heat shock 70 kDa protein 3
type: ProteinReference
xref: uniprot O65719 109
xref: PTHR19375:SF413
organism: Arabidopsis thaliana

Casein kinase II subunit beta-2
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot Q8TG11 937
organism: Neurospora crassa

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r1
control type: INHIBITION
controller: beta-Synuclein

uniprot Q4Q745 198
type: UnificationXref
id: Q4Q745
db: uniprot

Probable proteasome subunit beta type-7
type: ProteinReference
xref: uniprot Q9USQ9 723
xref: PTHR11599:SF5
organism: Schizosaccharomyces pombe

uniprot O65719 109
type: UnificationXref
id: O65719
db: uniprot

PTHR11909:SF139
type: RelationshipXref
id: PTHR11909:SF139
db: PANTHER Family
relationship type: By Homology

ncbitaxon 100226 183
type: UnificationXref
id: 100226
db: ncbitaxon

uniprot Q7Q797 701
type: UnificationXref
id: Q7Q797
db: uniprot

uniprot P40303 642
type: UnificationXref
id: P40303
db: uniprot

uniprot Q9C615 387
type: UnificationXref
id: Q9C615
db: uniprot

uniprot B0S610 58
type: UnificationXref
id: B0S610
db: uniprot

uniprot Q96299 1073
type: UnificationXref
id: Q96299
db: uniprot

uniprot Q05876 812
type: UnificationXref
id: Q05876
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot E2RSB0 418
organism: Canis lupus familiaris

Casein kinase I isoform alpha
type: ProteinReference
xref: uniprot P48729 1152
xref: PTHR11909:SF84
organism: Homo sapiens

PTHR11909:SF18
type: RelationshipXref
id: PTHR11909:SF18
db: PANTHER Family
relationship type: By Homology

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot A8XFM4 536
xref: PTHR11599:SF15
organism: Caenorhabditis briggsae

uniprot P06239 790
type: UnificationXref
id: P06239
db: uniprot

Casein kinase I isoform delta
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot P48730 1153
organism: Homo sapiens

uniprot H3E674 101
type: UnificationXref
id: H3E674
db: uniprot

uniprot Q6TGV6 690
type: UnificationXref
id: Q6TGV6
db: uniprot

Ubc6
type: ProteinReference
xref: P01222
standard name: Ubiquitin-conjugating enzyme 6
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.Ubc6
comment: ENTITY_REFERENCE_NOTES= Long Name: Ubiquitin-conjugating enzyme 6 Synonym: Synonym not specified Accession: P01222
member entity reference: Ube2j2 protein
member entity reference: AGAP005954-PA
member entity reference: Ubiquitin-conjugating enzyme E2 J2
member entity reference: Ubiquitin conjugating enzyme E2 J2
member entity reference: Similar to Ubc6p homolog, isoform CRA_a
member entity reference: HL05730p
member entity reference: Uncharacterized protein

SEPT1 isoform 3
type: ProteinReference
xref: uniprot H2QAX3 508
organism: Pan troglodytes

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 150

uniprot Q9LSU0 716
type: UnificationXref
id: Q9LSU0
db: uniprot

14-3-3-like protein GF14 omega
type: ProteinReference
xref: PTHR18860:SF83
xref: uniprot Q01525 1041
organism: Arabidopsis thaliana

uniprot Q7Q320 700
type: UnificationXref
id: Q7Q320
db: uniprot

uniprot E9GTE8 885
type: UnificationXref
id: E9GTE8
db: uniprot

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 379

PARTICIPANT STOICHIOMETRY r62 1349
type: Stoichiometry
physical entity: a157_degraded
stoichiometric coefficient: 1.0

Heat shock protein family A (Hsp70) member 2
type: ProteinReference
xref: uniprot E2QX84 67
xref: PTHR19375:SF382
organism: Canis lupus familiaris

uniprot F6V332 336
type: UnificationXref
id: F6V332
db: uniprot

uniprot Q5K8Z6 1053
type: UnificationXref
id: Q5K8Z6
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot F6XNK5 566
xref: PTHR11599:SF12
organism: Macaca mulatta

Stress-70 protein, mitochondrial
type: ProteinReference
xref: uniprot P48721 167
xref: PTHR19375:SF184
organism: Rattus norvegicus

Proteasome subunit beta
type: ProteinReference
xref: uniprot Q7Q306 699
xref: PTHR11599:SF44
organism: Anopheles gambiae

uniprot E9GCV0 883
type: UnificationXref
id: E9GCV0
db: uniprot

PARTICIPANT STOICHIOMETRY r62 1348
type: Stoichiometry
physical entity: Complex (TH/Parkin)
stoichiometric coefficient: 1.0

Proteasome subunit alpha type-6
type: ProteinReference
xref: uniprot O17586 596
xref: PTHR11599:SF11
organism: Caenorhabditis elegans

G protein-coupled receptor kinase
type: ProteinReference
xref: uniprot F7C5A3 854
xref: PTHR24355:SF18
organism: Xenopus tropicalis

uniprot P24864 354
type: UnificationXref
id: P24864
db: uniprot

Chaperone protein DnaK
type: ProteinReference
xref: uniprot Q9HRY2 241
xref: PTHR19375:SF184
organism: Halobacterium salinarum

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A7EJF2 268
organism: Sclerotinia sclerotiorum

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot F4JID0 1125
type: UnificationXref
id: F4JID0
db: uniprot

uniprot Q9LMM5 326
type: UnificationXref
id: Q9LMM5
db: uniprot

uniprot O96863 903
type: UnificationXref
id: O96863
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__O_glyc_alpha_Synuclein__Parkin_-_Ub-RIGHT__Complex__O_glyc_alpha_Synuclein__Parkin_-_r56
controller: UbcH7

Casein kinase II subunit beta
type: ProteinReference
xref: uniprot E9GTE8 885
xref: PTHR11740:SF0
organism: Daphnia pulex

Mitogen-activated protein kinase 15
type: ProteinReference
xref: PTHR24055:SF79
xref: uniprot Q9Z2A6 333
organism: Rattus norvegicus

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot Q9VK14 727
xref: PTHR11599:SF12
organism: Drosophila melanogaster

alpha-Synuclein
type: Complex
component stoichiometry: alpha Synuclein s2 a2 STOICHIOMETRY ID COMPLEX
component: alpha-Synuclein
cellular location: intracellular

alpha-Synuclein
type: Complex
component stoichiometry: alpha Synuclein s39 a56 STOICHIOMETRY ID COMPLEX
component: alpha-Synuclein
cellular location: intracellular

PTHR11849:SF133
type: RelationshipXref
id: PTHR11849:SF133
db: PANTHER Family
relationship type: By Homology

Casein kinase 1 gamma 2
type: ProteinReference
xref: PTHR11909:SF157
xref: uniprot E2QX25 1122
organism: Canis lupus familiaris

Y125 alpha Synuclein s87 sa25 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y125
feature location: Y125 alpha Synuclein s87 sa25 rs2 Y125
comment: MODIFICATION_RESIDUE_NAME=Y125
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.69

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7FHD1 283
xref: PTHR24055:SF203
organism: Monodelphis domestica

uniprot F6TJ80 79
type: UnificationXref
id: F6TJ80
db: uniprot

uniprot P32379 633
type: UnificationXref
id: P32379
db: uniprot

uniprot Q84RS4 933
type: UnificationXref
id: Q84RS4
db: uniprot

uniprot A0A1D5RJP1 1107
type: UnificationXref
id: A0A1D5RJP1
db: uniprot

uniprot F7E1T5 373
type: UnificationXref
id: F7E1T5
db: uniprot

Tyrosine-protein kinase Yes
type: ProteinReference
xref: PTHR24418:SF90
xref: uniprot Q28923 815
organism: Canis lupus familiaris

Os01g0254900 protein
type: ProteinReference
xref: uniprot Q9S7H0 389
organism: Oryza sativa

uniprot A2E4W5 29
type: UnificationXref
id: A2E4W5
db: uniprot

Complex (O-glyc/alpha-Synuclein/ Parkin)
type: Complex
component stoichiometry: O glyc s94 sa29 STOICHIOMETRY ID COMPLEX
component stoichiometry: Parkin s96 sa31 STOICHIOMETRY ID COMPLEX
component stoichiometry: alpha Synuclein s95 sa30 STOICHIOMETRY ID COMPLEX
component: alpha-Synuclein
component: O-glyc
component: Parkin
feature: COMPLEX BINDING FEATURE s108 a148 1229
feature: COMPLEX BINDING FEATURE s108 a148 1233
feature: COMPLEX BINDING FEATURE s108 a148 1231
cellular location: intracellular

uniprot A7RPJ6 1119
type: UnificationXref
id: A7RPJ6
db: uniprot

Proteasome subunit beta
type: ProteinReference
xref: uniprot F7DUU5 571
xref: PTHR11599:SF62
organism: Xenopus tropicalis

uniprot F1NC02 556
type: UnificationXref
id: F1NC02
db: uniprot

Pael-R
type: ProteinReference
xref: P01229
standard name: Endothelin receptor type B-like
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.Pael-R
comment: ENTITY_REFERENCE_NOTES= Long Name: Endothelin receptor type B-like Synonym: EDNRBL,Gpr37 Accession: P01229
member entity reference: Endothelin B receptor-like protein 2
member entity reference: Prosaposin receptor GPR37
member entity reference: G-protein coupled receptor 37-like 1
member entity reference: G protein-coupled receptor 37 like 1
member entity reference: G protein-coupled receptor 37
member entity reference: Putative G-protein coupled receptor 37

Casein kinase I isoform epsilon
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot Q9JMK2 1191
organism: Mus musculus

uniprot Q5QMY9 1162
type: UnificationXref
id: Q5QMY9
db: uniprot

uniprot O14936 842
type: UnificationXref
id: O14936
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot E9AFW0 551
organism: Leishmania major

ncbitaxon 5759 65
type: UnificationXref
id: 5759
db: ncbitaxon

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 13

uniprot P61983 1026
type: UnificationXref
id: P61983
db: uniprot

a157_degraded
type: PhysicalEntity
cellular location: intracellular
comment: SPECIES_TYPE=DEGRADED

Torsin family 1 member A
type: ProteinReference
xref: uniprot H2RGT2 454
xref: PTHR10760:SF15
organism: Pan troglodytes

uniprot Q62915 846
type: UnificationXref
id: Q62915
db: uniprot

Os01g0570500 protein
type: ProteinReference
xref: PTHR11909:SF323
xref: uniprot Q656Y0 1168
organism: Oryza sativa

PTHR11909:SF20
type: RelationshipXref
id: PTHR11909:SF20
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__Synphilin-_Parkin-RIGHT__Complex__Synphilin_Parkin_-_r41
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 1323
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 1324
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 1322
left: Synphilin
left: Parkin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Synphilin/Parkin)

Syntaxin-12
type: ProteinReference
xref: PTHR19957:SF88
xref: uniprot Q86Y82 386
organism: Homo sapiens

uniprot O43236 511
type: UnificationXref
id: O43236
db: uniprot

uniprot A8BCR6 41
type: UnificationXref
id: A8BCR6
db: uniprot

uniprot F7EVY1 486
type: UnificationXref
id: F7EVY1
db: uniprot

AGAP004192-PA
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot Q7PQK5 220
organism: Anopheles gambiae

uniprot H2QXV4 587
type: UnificationXref
id: H2QXV4
db: uniprot

AGAP001056-PA
type: ProteinReference
xref: uniprot Q7QDD7 479
organism: Anopheles gambiae

PTHR11909:SF157
type: RelationshipXref
id: PTHR11909:SF157
db: PANTHER Family
relationship type: By Homology

uniprot F7F3A6 575
type: UnificationXref
id: F7F3A6
db: uniprot

uniprot Q8TG13 939
type: UnificationXref
id: Q8TG13
db: uniprot

PTHR11909:SF151
type: RelationshipXref
id: PTHR11909:SF151
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5Q5Z6 265
type: UnificationXref
id: A0A1D5Q5Z6
db: uniprot

PTHR11909:SF155
type: RelationshipXref
id: PTHR11909:SF155
db: PANTHER Family
relationship type: By Homology

PTHR11909:SF156
type: RelationshipXref
id: PTHR11909:SF156
db: PANTHER Family
relationship type: By Homology

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
type: ProteinReference
xref: uniprot P19234 948
xref: PTHR10371:SF3
organism: Rattus norvegicus

uniprot A8XFP5 873
type: UnificationXref
id: A8XFP5
db: uniprot

ncbitaxon 54126 102
type: UnificationXref
id: 54126
db: ncbitaxon

uniprot A8WMC8 838
type: UnificationXref
id: A8WMC8
db: uniprot

Sodium-dependent dopamine transporter
type: ProteinReference
xref: PTHR11616:SF38
xref: uniprot Q61327 739
organism: Mus musculus

Proteasome subunit beta type-1
type: ProteinReference
xref: uniprot O09061 593
xref: PTHR11599:SF59
organism: Mus musculus

uniprot P54936 844
type: UnificationXref
id: P54936
db: uniprot

uniprot E2RMN2 548
type: UnificationXref
id: E2RMN2
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot Q38CK9 667
organism: Trypanosoma brucei

uniprot F6Z866 569
type: UnificationXref
id: F6Z866
db: uniprot

PTHR11909:SF84
type: RelationshipXref
id: PTHR11909:SF84
db: PANTHER Family
relationship type: By Homology

uniprot O23715 599
type: UnificationXref
id: O23715
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6V332 336
xref: PTHR24055:SF110
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r28 1355
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r28 1356
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

Heat shock protein 70
type: ProteinReference
xref: uniprot Q383E5 189
xref: PTHR19375:SF395
organism: Trypanosoma brucei

Proteasome subunit alpha type-5
type: ProteinReference
xref: uniprot P28066 632
xref: PTHR11599:SF14
organism: Homo sapiens

uniprot Q4KM97 817
type: UnificationXref
id: Q4KM97
db: uniprot

Cul-1
type: ProteinReference
xref: P01239
standard name: F-box and WD-40 domain protein 7
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.Cul-1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Cullin 1b
member entity reference: Cullin homolog 1
member entity reference: Cullin
member entity reference: Cullin-1
member entity reference: Uncharacterized protein
member entity reference: Cullin 1
member entity reference: Cul1 protein
member entity reference: CUL1 isoform 1
member entity reference: Cullin 1a
member entity reference: SCF ubiquitin ligase complex subunit CulA, putative (AFU_orthologue AFUA_1G12960)

Heat shock protein family A (Hsp70) member 5
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot F6UZ27 81
organism: Xenopus tropicalis

uniprot Q7Q306 699
type: UnificationXref
id: Q7Q306
db: uniprot

Heat shock protein 70, putative
type: ProteinReference
xref: PTHR19375:SF447
xref: uniprot Q383E9 191
organism: Trypanosoma brucei

PTHR11849:SF178
type: RelationshipXref
id: PTHR11849:SF178
db: PANTHER Family
relationship type: By Homology

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 231

Uncharacterized protein
type: ProteinReference
xref: uniprot F6T0Y1 504
organism: Ornithorhynchus anatinus

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

PARTICIPANT STOICHIOMETRY r69 1337
type: Stoichiometry
physical entity: Complex (CDCrel-1/Parkin)
stoichiometric coefficient: 1.0

PTHR11599:SF114
type: RelationshipXref
id: PTHR11599:SF114
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r69 1336
type: Stoichiometry
physical entity: Complex (CDCrel-1/Parkin)
stoichiometric coefficient: 1.0

PTHR11599:SF113
type: RelationshipXref
id: PTHR11599:SF113
db: PANTHER Family
relationship type: By Homology

PTHR11599:SF110
type: RelationshipXref
id: PTHR11599:SF110
db: PANTHER Family
relationship type: By Homology

uniprot Q9VUJ1 729
type: UnificationXref
id: Q9VUJ1
db: uniprot

PTHR11909:SF97
type: RelationshipXref
id: PTHR11909:SF97
db: PANTHER Family
relationship type: By Homology

14-3-3-like protein 1
type: ProteinReference
xref: PTHR18860:SF21
xref: uniprot P41932 1015
organism: Caenorhabditis elegans

NAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000303 340

uniprot P51451 809
type: UnificationXref
id: P51451
db: uniprot

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 256

Heat shock protein family A (Hsp70) member 5
type: ProteinReference
xref: uniprot F1PIC7 72
xref: PTHR19375:SF144
organism: Canis lupus familiaris

ncbitaxon 83332 180
type: UnificationXref
id: 83332
db: ncbitaxon

uniprot J9P9W3 1138
type: UnificationXref
id: J9P9W3
db: uniprot

ncbitaxon 237561 166
type: UnificationXref
id: 237561
db: ncbitaxon

Chaperone protein DnaK
type: ProteinReference
xref: uniprot P17821 142
xref: PTHR19375:SF184
organism: Chlamydia trachomatis

uniprot F6W7B6 484
type: UnificationXref
id: F6W7B6
db: uniprot

Chaperone protein DnaK
type: ProteinReference
xref: uniprot P17820 140
xref: PTHR19375:SF184
organism: Bacillus subtilis

PARTICIPANT STOICHIOMETRY r49 1295
type: Stoichiometry
physical entity: Complex (Parkin/Pael-R)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r49 1294
type: Stoichiometry
physical entity: Complex (Parkin/Pael-R)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24068:SF135
xref: uniprot F7A451 466
organism: Monodelphis domestica

STATE_TRANSITION_LEFT__p38_MAPK-RIGHT__p38_MAPK-_r47
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 1302
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 1301
left: p38 MAPK
interaction type: STATE_TRANSITION
right: p38 MAPK

PARTICIPANT STOICHIOMETRY r49 1293
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

Proteasome subunit beta type-3
type: ProteinReference
xref: uniprot P33672 634
xref: PTHR11599:SF62
organism: Bos taurus

Fyn kinase
type: Protein
entity reference: Fyn kinase
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot O62236 380
type: UnificationXref
id: O62236
db: uniprot

PTHR11909:SF72
type: RelationshipXref
id: PTHR11909:SF72
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot K7AWV1 786
xref: PTHR24418:SF407
organism: Pan troglodytes

Neuronal proto-oncogene tyrosine-protein kinase Src
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot P05480 789
organism: Mus musculus

uniprot P35507 1144
type: UnificationXref
id: P35507
db: uniprot

Heat shock-related 70 kDa protein 2
type: ProteinReference
xref: uniprot P54652 168
xref: PTHR19375:SF382
organism: Homo sapiens

E3 ubiquitin-protein ligase parkin
type: ProteinReference
xref: PTHR11685:SF212
xref: uniprot Q9WVS6 393
organism: Mus musculus

Mitogen-activated protein kinase 7
type: ProteinReference
xref: PTHR24055:SF356
xref: uniprot Q9WVS8 332
organism: Mus musculus

Protein CBR-KIN-3
type: ProteinReference
xref: PTHR24054:SF0
xref: uniprot A8XFP5 873
organism: Caenorhabditis briggsae

uniprot A9SNF1 55
type: UnificationXref
id: A9SNF1
db: uniprot

uniprot Q9Z0F7 834
type: UnificationXref
id: Q9Z0F7
db: uniprot

uniprot F1PBL1 980
type: UnificationXref
id: F1PBL1
db: uniprot

YALI0D00737p
type: ProteinReference
xref: uniprot F2Z6C0 944
xref: PTHR10371:SF3
organism: Yarrowia lipolytica

Ubc6
type: Protein
entity reference: Ubc6
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot E2RSH8 763
type: UnificationXref
id: E2RSH8
db: uniprot

ncbitaxon 3702 110
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot Q24210 845
type: UnificationXref
id: Q24210
db: uniprot

uniprot Q5XGC8 1057
type: UnificationXref
id: Q5XGC8
db: uniprot

uniprot H2QAX3 508
type: UnificationXref
id: H2QAX3
db: uniprot

Candida albicans
type: BioSource
xref: ncbitaxon 237561 166

ncbitaxon 3218 53
type: UnificationXref
id: 3218
db: ncbitaxon

uniprot Q6P4Z5 1064
type: UnificationXref
id: Q6P4Z5
db: uniprot

uniprot P42209 515
type: UnificationXref
id: P42209
db: uniprot

Ubiquitin conjugating enzyme E2 J2
type: ProteinReference
xref: PTHR24068:SF135
xref: uniprot F7C4Y9 467
organism: Ornithorhynchus anatinus

uniprot E1B8P9 272
type: UnificationXref
id: E1B8P9
db: uniprot

uniprot H2QXX6 453
type: UnificationXref
id: H2QXX6
db: uniprot

uniprot P19454 908
type: UnificationXref
id: P19454
db: uniprot

Probable proteasome subunit alpha type-5
type: ProteinReference
xref: uniprot Q9UT97 724
xref: PTHR11599:SF14
organism: Schizosaccharomyces pombe

uniprot D6XCY8 541
type: UnificationXref
id: D6XCY8
db: uniprot

14-3-3-like protein
type: ProteinReference
xref: uniprot P54632 1023
xref: PTHR18860:SF17
organism: Dictyostelium discoideum

SEPT2 isoform 11
type: ProteinReference
xref: uniprot H2R3C4 510
organism: Pan troglodytes

uniprot P78695 174
type: UnificationXref
id: P78695
db: uniprot

Syntaxin-7
type: ProteinReference
xref: uniprot O15400 378
xref: PTHR19957:SF90
organism: Homo sapiens

uniprot A7Z057 966
type: UnificationXref
id: A7Z057
db: uniprot

uniprot P20029 146
type: UnificationXref
id: P20029
db: uniprot

Mitochondrial-type HSP70, putative
type: ProteinReference
xref: uniprot A2EKF3 31
xref: PTHR19375:SF184
organism: Trichomonas vaginalis

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot A7F3M0 270
organism: Sclerotinia sclerotiorum

Parkin s93 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

uniprot A0NBC2 965
type: UnificationXref
id: A0NBC2
db: uniprot

ncbitaxon 5722 26
type: UnificationXref
id: 5722
db: ncbitaxon

uniprot P23292 1142
type: UnificationXref
id: P23292
db: uniprot

uniprot E7F354 977
type: UnificationXref
id: E7F354
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot Q7Q2B0 698
organism: Anopheles gambiae

CSNK1D isoform 8
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot A0A2I3RNK5 1116
organism: Pan troglodytes

uniprot Q91Y81 523
type: UnificationXref
id: Q91Y81
db: uniprot

uniprot P0DMV8 123
type: UnificationXref
id: P0DMV8
db: uniprot

ncbitaxon 7719 591
type: UnificationXref
id: 7719
db: ncbitaxon

uniprot F7H1B9 93
type: UnificationXref
id: F7H1B9
db: uniprot

Heat shock cognate 70 kDa protein 1
type: ProteinReference
xref: PTHR19375:SF426
xref: uniprot P36415 158
organism: Dictyostelium discoideum

Heat shock 70 kDa protein 1-like
type: ProteinReference
xref: uniprot P16627 137
xref: PTHR19375:SF210
organism: Mus musculus

uniprot Q9USQ9 723
type: UnificationXref
id: Q9USQ9
db: uniprot

uniprot Q9QY42 747
type: UnificationXref
id: Q9QY42
db: uniprot

uniprot F6S8L5 769
type: UnificationXref
id: F6S8L5
db: uniprot

Casein kinase I isoform alpha
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot P54367 1155
organism: Drosophila melanogaster

uniprot H2QKQ2 585
type: UnificationXref
id: H2QKQ2
db: uniprot

uniprot P38647 162
type: UnificationXref
id: P38647
db: uniprot

DNA damage checkpoint protein rad24
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot P42656 1018
organism: Schizosaccharomyces pombe

DNA damage checkpoint protein rad25
type: ProteinReference
xref: uniprot P42657 1019
xref: PTHR18860:SF17
organism: Schizosaccharomyces pombe

uniprot P26818 862
type: UnificationXref
id: P26818
db: uniprot

AGAP002170-PA
type: ProteinReference
xref: uniprot Q7QK64 954
xref: PTHR10371:SF3
organism: Anopheles gambiae

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot F6QW93 560
xref: PTHR11599:SF14
organism: Monodelphis domestica

AGAP002169-PA
type: ProteinReference
xref: PTHR24067:SF154
xref: uniprot Q7QK63 447
organism: Anopheles gambiae

HSPA8 isoform 16
type: ProteinReference
xref: uniprot A0A2J8N1X7 24
xref: PTHR19375:SF379
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5NXE7 1094
organism: Gallus gallus

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P79996 438
xref: PTHR24055:SF172
organism: Gallus gallus

uniprot A0A2I3RHK0 1114
type: UnificationXref
id: A0A2I3RHK0
db: uniprot

uniprot A0A1D5RAI3 750
type: UnificationXref
id: A0A1D5RAI3
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q38AI6 301
organism: Trypanosoma brucei

uniprot A4FV00 416
type: UnificationXref
id: A4FV00
db: uniprot

Giardia intestinalis
type: BioSource
xref: ncbitaxon 184922 40

uniprot P63085 296
type: UnificationXref
id: P63085
db: uniprot

14-3-3-like protein GF14 upsilon
type: ProteinReference
xref: PTHR18860:SF101
xref: uniprot P42645 1017
organism: Arabidopsis thaliana

uniprot A0A2I3SKP4 752
type: UnificationXref
id: A0A2I3SKP4
db: uniprot

14-3-3-like protein GF14 psi
type: ProteinReference
xref: PTHR18860:SF95
xref: uniprot P42644 1016
organism: Arabidopsis thaliana

PTHR19375:SF168
type: RelationshipXref
id: PTHR19375:SF168
db: PANTHER Family
relationship type: By Homology

S129 alpha Synuclein s18 a21 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S129
feature location: S129 alpha Synuclein s18 a21 rs1 S129
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S129
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

uniprot Q6AYR4 459
type: UnificationXref
id: Q6AYR4
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot A9S0A3 54
organism: Physcomitrella patens

14-3-3 protein eta
type: ProteinReference
xref: PTHR18860:SF16
xref: uniprot F6RIX6 982
organism: Macaca mulatta

uniprot Q9V9J3 826
type: UnificationXref
id: Q9V9J3
db: uniprot

14-3-3 protein eta
type: ProteinReference
xref: uniprot Q04917 1042
xref: PTHR18860:SF16
organism: Homo sapiens

Tyrosine-protein kinase FRK
type: ProteinReference
xref: uniprot P42685 807
xref: PTHR24418:SF419
organism: Homo sapiens

Predicted protein
type: ProteinReference
xref: uniprot A9THD0 876
xref: PTHR24054:SF0
organism: Physcomitrella patens

PTHR19375:SF157
type: RelationshipXref
id: PTHR19375:SF157
db: PANTHER Family
relationship type: By Homology

uniprot Q27575 662
type: UnificationXref
id: Q27575
db: uniprot

Probable proteasome subunit beta type-3
type: ProteinReference
xref: uniprot Q9Y7T8 733
xref: PTHR11599:SF62
organism: Schizosaccharomyces pombe

TRANSPORT_LEFT__DA-RIGHT__DA-_r4
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1299
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1300
left: DA
interaction type: TRANSPORT
right: DA

DnaK-type molecular chaperone hsp70-rice
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot Q53NM9 203
organism: Oryza sativa

uniprot Q8IB24 227
type: UnificationXref
id: Q8IB24
db: uniprot

Syntaxin-23
type: ProteinReference
xref: uniprot O04378 377
organism: Arabidopsis thaliana

uniprot A0A1D5P321 496
type: UnificationXref
id: A0A1D5P321
db: uniprot

uniprot F6RLH5 76
type: UnificationXref
id: F6RLH5
db: uniprot

uniprot P33567 397
type: UnificationXref
id: P33567
db: uniprot

Septin-4
type: ProteinReference
xref: uniprot O43236 511
organism: Homo sapiens

uniprot H2Q0W6 742
type: UnificationXref
id: H2Q0W6
db: uniprot

uniprot F1Q7M5 1081
type: UnificationXref
id: F1Q7M5
db: uniprot

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot A4GTP4 847
organism: Rattus norvegicus

PTHR19375:SF144
type: RelationshipXref
id: PTHR19375:SF144
db: PANTHER Family
relationship type: By Homology

uniprot Q9S5X7 958
type: UnificationXref
id: Q9S5X7
db: uniprot

uniprot F1Q126 1124
type: UnificationXref
id: F1Q126
db: uniprot

alpha Synuclein s2 a2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 8.0

uniprot F7FGS3 1100
type: UnificationXref
id: F7FGS3
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot F7FG65 776
organism: Monodelphis domestica

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF419
xref: uniprot F7G2C9 778
organism: Macaca mulatta

UbcH7
type: Protein
entity reference: UbcH7
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF42
xref: uniprot F7BV42 774
organism: Macaca mulatta

uniprot G7MHX1 1000
type: UnificationXref
id: G7MHX1
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot Q8T0Y8 706
organism: Anopheles gambiae

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 11

PTHR10371:SF3
type: RelationshipXref
id: PTHR10371:SF3
db: PANTHER Family
relationship type: By Homology

Gamma-synuclein
type: ProteinReference
xref: uniprot A0A2I3TBD9 828
organism: Pan troglodytes

S129 alpha Synuclein s29 sa4 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S129
feature location: S129 alpha Synuclein s29 sa4 rs1 S129
comment: MODIFICATION_RESIDUE_NAME=S129
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

CDCrel-1
type: Protein
entity reference: CDCrel-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s118 sa40 1258
feature: CDCrel 1 s118 sa40 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: uniprot P20029 146
xref: PTHR19375:SF144
organism: Mus musculus

uniprot Q9VG58 252
type: UnificationXref
id: Q9VG58
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF13
xref: uniprot Q57X58 678
organism: Trypanosoma brucei

Proteasome subunit beta
type: ProteinReference
xref: uniprot Q7K6A9 693
xref: PTHR11599:SF5
organism: Plasmodium falciparum

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot A0A1D5QLV9 528
xref: PTHR11599:SF13
organism: Macaca mulatta

Proteasome subunit beta type-10
type: ProteinReference
xref: PTHR11599:SF41
xref: uniprot O35955 601
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot H3FT78 1135
organism: Pristionchus pacificus

uniprot Q9S7H0 389
type: UnificationXref
id: Q9S7H0
db: uniprot

uniprot P42644 1016
type: UnificationXref
id: P42644
db: uniprot

uniprot Q9VX36 960
type: UnificationXref
id: Q9VX36
db: uniprot

PARTICIPANT STOICHIOMETRY r51 1391
type: Stoichiometry
physical entity: Cyclin E
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 1390
type: Stoichiometry
physical entity: Cyclin E
stoichiometric coefficient: 1.0

uniprot F7HN06 578
type: UnificationXref
id: F7HN06
db: uniprot

ncbitaxon 9913 20
type: UnificationXref
id: 9913
db: ncbitaxon

G1/S-specific cyclin-E1
type: ProteinReference
xref: uniprot P24864 354
xref: PTHR10177:SF71
organism: Homo sapiens

uniprot Q0VBZ0 814
type: UnificationXref
id: Q0VBZ0
db: uniprot

uniprot H2Q378 581
type: UnificationXref
id: H2Q378
db: uniprot

uniprot P40112 639
type: UnificationXref
id: P40112
db: uniprot

uniprot Q95005 709
type: UnificationXref
id: Q95005
db: uniprot

Casein kinase II subunit beta
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot P08182 905
organism: Drosophila melanogaster

uniprot A0A1D5QXI6 851
type: UnificationXref
id: A0A1D5QXI6
db: uniprot

Casein kinase II subunit alpha
type: ProteinReference
xref: uniprot P08181 904
xref: PTHR24054:SF0
organism: Drosophila melanogaster

uniprot Q8N2K1 471
type: UnificationXref
id: Q8N2K1
db: uniprot

Heat shock cognate 71 kDa protein
type: ProteinReference
xref: uniprot P63018 172
xref: PTHR19375:SF379
organism: Rattus norvegicus

uniprot G1K268 94
type: UnificationXref
id: G1K268
db: uniprot

uniprot Q1KMU1 1089
type: UnificationXref
id: Q1KMU1
db: uniprot

Heat shock cognate 71 kDa protein
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot P63017 171
organism: Mus musculus

Predicted protein
type: ProteinReference
xref: uniprot A9SBU0 874
xref: PTHR24054:SF0
organism: Physcomitrella patens

uniprot O60999 1087
type: UnificationXref
id: O60999
db: uniprot

uniprot F7BHF8 773
type: UnificationXref
id: F7BHF8
db: uniprot

TH s97 sa32 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot O13790 1086
type: UnificationXref
id: O13790
db: uniprot

Parkinson disease
type: Pathway
pathway component: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__a1_degraded-_r18
pathway component: STATE_TRANSITION_LEFT__DAT-RIGHT__Complex__DAT_O_C342_-_r72
pathway component: STATE_TRANSITION_LEFT__p38_MAPK-RIGHT__p38_MAPK-_r47
pathway component: HETERODIMER_ASSOCIATION_LEFT__CDCrel_1-_Parkin-RIGHT__Complex__CDCrel_1_Parkin_-_r68
pathway component: TRANSPORT_LEFT__DA-RIGHT__DA-_r4
pathway component: STATE_TRANSITION_LEFT__Complex__Synphilin_Parkin_-RIGHT__a92_degraded-_r42
pathway component: STATE_TRANSITION_LEFT__SAPK-RIGHT__SAPK-_r36
pathway component: STATE_TRANSITION_LEFT__O2-RIGHT__H2O2-_r39
pathway component: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r45
pathway component: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r26
pathway component: TRANSCRIPTION_LEFT__DAT-RIGHT__DAT-_re48
pathway component: HETERODIMER_ASSOCIATION_LEFT__alpha_Synuclein-_19S_proteasome-RIGHT__Complex__19S_proteasome_alpha_Synuclein_-_r22
pathway component: STATE_TRANSITION_LEFT__Elk_1-RIGHT__Elk_1-_r35
pathway component: STATE_TRANSITION_LEFT__Complex__TH_Parkin_-_Ub-RIGHT__Complex__TH_Parkin_-_r59
pathway component: STATE_TRANSITION_LEFT__Complex__O_glyc_alpha_Synuclein__Parkin_-_Ub-RIGHT__Complex__O_glyc_alpha_Synuclein__Parkin_-_r56
pathway component: HETERODIMER_ASSOCIATION_LEFT__Parkin-_CASK-RIGHT__Complex__CASK_Parkin_-_r54
pathway component: STATE_TRANSITION_LEFT__Complex__CDCrel_1_Parkin_-RIGHT__a173_degraded-_r70
pathway component: STATE_TRANSITION_LEFT__O2-RIGHT__ROS-_r38
pathway component: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__Complex__O_glyc_alpha_Synuclein_-_r55
pathway component: HETERODIMER_ASSOCIATION_LEFT__Parkin-_Complex__O_glyc_alpha_Synuclein_-RIGHT__Complex__O_glyc_alpha_Synuclein__Parkin_-_r57
pathway component: STATE_TRANSITION_LEFT__Complex__O_glyc_alpha_Synuclein__Parkin_-RIGHT__a148_degraded-_r58
pathway component: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r1
pathway component: HETERODIMER_ASSOCIATION_LEFT__Pael_R-_Parkin-RIGHT__Complex__Parkin_Pael_R_-_r48
pathway component: STATE_TRANSITION_LEFT__Ub-_Parkin-RIGHT__Complex__Synphilin_Parkin_-_r43
pathway component: STATE_TRANSITION_LEFT__Complex__Parkin_Pael_R_-RIGHT__a109_degraded-_r50
pathway component: STATE_TRANSITION_LEFT__Cyclin_E-RIGHT__Cyclin_E-_r51
pathway component: HETERODIMER_ASSOCIATION_LEFT__TH-_Parkin-RIGHT__Complex__TH_Parkin_-_r60
pathway component: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__Complex__N_Y125_alpha_Synuclein_-_r53
pathway component: STATE_TRANSITION_LEFT__Complex__TH_Parkin_-RIGHT__a157_degraded-_r62
pathway component: STATE_TRANSITION_LEFT__Complex__CDCrel_1_Parkin_-RIGHT__Complex__CDCrel_1_Parkin_-_r69
pathway component: STATE_TRANSITION_LEFT__PLD2-RIGHT__PLD2-_r12
pathway component: STATE_TRANSITION_LEFT__MPTP-RIGHT__MPP_PLUS_-_r2
pathway component: STATE_TRANSITION_LEFT__Ub-_Complex__Parkin_Pael_R_-RIGHT__Complex__Parkin_Pael_R_-_r49
pathway component: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r27
pathway component: STATE_TRANSITION_LEFT__L_tyrosine-RIGHT__L_DOPA-_r61
pathway component: STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r46
pathway component: TRANSLATION_LEFT__DAT-RIGHT__DAT-_r74
pathway component: TRANSPORT_LEFT__MPP_PLUS_-RIGHT__MPP_PLUS_-_r3
pathway component: STATE_TRANSITION_LEFT__Complex_I-RIGHT__Complex_I-_r7
pathway component: HETERODIMER_ASSOCIATION_LEFT__Syntaxin-_CDCrel_1-RIGHT__Complex__CDCrel_1_Syntaxin_-_r71
pathway component: HETERODIMER_ASSOCIATION_LEFT__14_3_3-_alpha_Synuclein-RIGHT__Complex__14_3_3_alpha_Synuclein_-_r31
pathway component: STATE_TRANSITION_LEFT__Cyclin_E-RIGHT__a119_degraded-_r52
pathway component: HETERODIMER_ASSOCIATION_LEFT__Synphilin-_Parkin-RIGHT__Complex__Synphilin_Parkin_-_r41
pathway component: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r28
pathway component: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r44
pathway component: DISSOCIATION_LEFT__Complex__19S_proteasome_20S_proteasome_-RIGHT__20S_proteasome-_19S_proteasome-_r21
pathway component: HETERODIMER_ASSOCIATION_LEFT__alpha_Synuclein-_Synphilin-RIGHT__Complex__Synphilin_alpha_Synuclein_-_r23
xref: PANTHER Pathway P00049 1
comment: MODEL_NOTES=Panther Pathway: P00049 Parkinson's disease is characterized neuropathologically by the death of dopaminergic cells in the substantia nigra and the accumulation of alpha-synuclein-positive Lewy bodies. Mutations in alpha-synuclein have been linked to Parkinson's disease, while mutations in parkin have been linked to juvenile-onset PD. Synuclein is a phosphoprotein that aggregates to form the backbone of Lewy bodies. Parkin is a ubiquitin E3 protein that assists in the ubiquitination and phosphorylation of multiple substrates. Medline=11433374 Medline=11580890 Medline=12526767 Medline=12814656 Medline=12814657 Medline=12846976 Medline=12859888 Medline=12971891 Medline=14593166 PMID: 11433374 PMID: 11580890 PMID: 12526767 PMID: 12814656 PMID: 12814657 PMID: 12846976 PMID: 12859888 PMID: 12971891 PMID: 14593166

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot Q38B02 666
xref: PTHR11599:SF12
organism: Trypanosoma brucei

CSNK2A1 isoform 3
type: ProteinReference
xref: PTHR24054:SF16
xref: uniprot K7D8P4 896
organism: Pan troglodytes

Mitogen-activated protein kinase 11
type: ProteinReference
xref: uniprot Q9LMM5 326
xref: PTHR24055:SF439
organism: Arabidopsis thaliana

uniprot Q3T0G8 406
type: UnificationXref
id: Q3T0G8
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot J9P9G4 592
xref: PTHR11599:SF12
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BEI4 351
xref: PTHR10177:SF71
organism: Macaca mulatta

uniprot E1B7G3 360
type: UnificationXref
id: E1B7G3
db: uniprot

Casein kinase I
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot Q8IHZ9 1176
organism: Plasmodium falciparum

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r1
control type: INHIBITION
controller: Hsp70

uniprot E1BZ66 465
type: UnificationXref
id: E1BZ66
db: uniprot

14-3-3 protein gamma
type: ProteinReference
xref: uniprot Q5F3W6 1052
xref: PTHR18860:SF22
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot F6R812 1127
organism: Monodelphis domestica

uniprot P50545 808
type: UnificationXref
id: P50545
db: uniprot

hSel10
type: ProteinReference
xref: P01240
standard name: F-box and WD-40 domain protein 7
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.hSel10
comment: ENTITY_REFERENCE_NOTES=
member entity reference: F-box/WD repeat-containing protein 7
member entity reference: F-box and WD repeat domain containing 7
member entity reference: F-box/WD repeat-containing protein 11
member entity reference: F-box/WD repeat-containing protein 7 isoform 1
member entity reference: F-box and WD repeat domain containing 11
member entity reference: F-box and WD repeat domain-containing 11
member entity reference: Uncharacterized protein

Synphilin s30 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Synphilin
stoichiometric coefficient: 1.0

uniprot P29845 156
type: UnificationXref
id: P29845
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__O_glyc_alpha_Synuclein__Parkin_-RIGHT__a148_degraded-_r58
controller: Complex (19S proteasome/20S proteasome)

ERK
type: Protein
entity reference: ERK
feature: ERK s70 a98 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 7

uniprot Q6PGX4 214
type: UnificationXref
id: Q6PGX4
db: uniprot

S129 alpha Synuclein s2 a2 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S129
feature location: S129 alpha Synuclein s2 a2 rs1 S129
comment: MODIFICATION_RESIDUE_NAME=S129
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

Major heat shock 70 kDa protein Aa
type: ProteinReference
xref: PTHR19375:SF371
xref: uniprot P82910 176
organism: Drosophila melanogaster

Mitogen-activated protein kinase 15
type: ProteinReference
xref: PTHR24055:SF79
xref: uniprot Q80Y86 318
organism: Mus musculus

uniprot O80507 900
type: UnificationXref
id: O80507
db: uniprot

Heat shock 70 kDa protein 10, mitochondrial
type: ProteinReference
xref: uniprot Q9LDZ0 245
xref: PTHR19375:SF184
organism: Arabidopsis thaliana

Bip
type: ProteinReference
xref: uniprot A8B431 39
xref: PTHR19375:SF144
organism: Giardia intestinalis

uniprot Q9VYN5 1200
type: UnificationXref
id: Q9VYN5
db: uniprot

Proteasome subunit beta
type: ProteinReference
xref: uniprot Q7Q320 700
xref: PTHR11599:SF5
organism: Anopheles gambiae

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 234

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot Q9DGD9 444
organism: Danio rerio

uniprot A0A3Q1LWJ8 414
type: UnificationXref
id: A0A3Q1LWJ8
db: uniprot

DAT
type: Protein
entity reference: DAT
feature: ACTIVE 21
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F1NEQ6 557
type: UnificationXref
id: F1NEQ6
db: uniprot

Mitogen-activated protein kinase 14B
type: ProteinReference
xref: uniprot Q9DGE1 345
xref: PTHR24055:SF110
organism: Danio rerio

MPP+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9NZ50 833
type: UnificationXref
id: Q9NZ50
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot C4LUL4 538
xref: PTHR11599:SF14
organism: Entamoeba histolytica

uniprot F2Z6C0 944
type: UnificationXref
id: F2Z6C0
db: uniprot

uniprot A8WUP0 532
type: UnificationXref
id: A8WUP0
db: uniprot

Hsp70
type: Protein
entity reference: Hsp70
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Beta-adrenergic receptor kinase 1
type: ProteinReference
xref: PTHR24355:SF22
xref: uniprot P21146 859
organism: Bos taurus

uniprot Q7ZU33 932
type: UnificationXref
id: Q7ZU33
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E2RC09 761
xref: PTHR24418:SF44
organism: Canis lupus familiaris

uniprot F7H415 1133
type: UnificationXref
id: F7H415
db: uniprot

uniprot F6WMM9 84
type: UnificationXref
id: F6WMM9
db: uniprot

STATE_TRANSITION_LEFT__L_tyrosine-RIGHT__L_DOPA-_r61
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 1351
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 1350
left: L-tyrosine
interaction type: STATE_TRANSITION
right: L-DOPA

PARTICIPANT STOICHIOMETRY r4 1299
type: Stoichiometry
physical entity: DA
stoichiometric coefficient: 1.0

uniprot P68511 1039
type: UnificationXref
id: P68511
db: uniprot

14-3-3 protein epsilon
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot Q5ZMT0 1062
organism: Gallus gallus

Heat shock 70kDa protein
type: ProteinReference
xref: uniprot A9JTJ5 50
xref: PTHR19375:SF388
organism: Xenopus tropicalis

uniprot P61981 1024
type: UnificationXref
id: P61981
db: uniprot

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: uniprot Q90593 236
xref: PTHR19375:SF144
organism: Gallus gallus

uniprot Q38D21 926
type: UnificationXref
id: Q38D21
db: uniprot

Elk-1
type: ProteinReference
xref: P01233
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.Elk-1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Elk-1 Synonym: Synonym not specified Accession: P01233
member entity reference: ETS domain-containing protein Elk-1
member entity reference: Transcription factor Elk; Uncharacterized protein

uniprot F6WS89 564
type: UnificationXref
id: F6WS89
db: uniprot

uniprot P21243 621
type: UnificationXref
id: P21243
db: uniprot

Proteasome subunit beta type-3
type: ProteinReference
xref: uniprot P49720 645
xref: PTHR11599:SF62
organism: Homo sapiens

Proteasome subunit alpha type-2
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot P49722 646
organism: Mus musculus

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot H2RC87 1004
type: UnificationXref
id: H2RC87
db: uniprot

Torsin-2A
type: ProteinReference
xref: PTHR10760:SF4
xref: uniprot Q6AYR4 459
organism: Rattus norvegicus

uniprot E2RTW7 550
type: UnificationXref
id: E2RTW7
db: uniprot

Heat shock 70 kDa protein 7, chloroplastic
type: ProteinReference
xref: uniprot Q9LTX9 248
xref: PTHR19375:SF184
organism: Arabidopsis thaliana

uniprot A2DCR4 25
type: UnificationXref
id: A2DCR4
db: uniprot

uniprot P0DMV9 124
type: UnificationXref
id: P0DMV9
db: uniprot

Complex (Parkin/Pael-R)
type: Complex
component stoichiometry: Pael R s44 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: Parkin s43 sa15 STOICHIOMETRY ID COMPLEX
component: Pael-R
component: Parkin
feature: COMPLEX BINDING FEATURE s80 a109 1275
feature: COMPLEX BINDING FEATURE s80 a109 1273
cellular location: intracellular

uniprot Q0V9W8 1044
type: UnificationXref
id: Q0V9W8
db: uniprot

Proteasome subunit beta
type: ProteinReference
xref: uniprot Q9VUJ1 729
xref: PTHR11599:SF44
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot F7FPX9 1132
organism: Monodelphis domestica

Proteasome subunit alpha type-4-1
type: ProteinReference
xref: PTHR11599:SF13
xref: uniprot P0DKK3 613
organism: Oryza sativa

Probable heat shock protein ssa2
type: ProteinReference
xref: PTHR19375:SF426
xref: uniprot O59855 107
organism: Schizosaccharomyces pombe

uniprot O60883 745
type: UnificationXref
id: O60883
db: uniprot

Si:dkey-4p15.3
type: ProteinReference
xref: PTHR19375:SF457
xref: uniprot F1R9V3 74
organism: Danio rerio

uniprot F7DR73 855
type: UnificationXref
id: F7DR73
db: uniprot

uniprot P28548 911
type: UnificationXref
id: P28548
db: uniprot

uniprot C4LUL4 538
type: UnificationXref
id: C4LUL4
db: uniprot

uniprot F6R511 888
type: UnificationXref
id: F6R511
db: uniprot

uniprot F6T6M8 890
type: UnificationXref
id: F6T6M8
db: uniprot

uniprot A0A2I3T7K0 491
type: UnificationXref
id: A0A2I3T7K0
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 46

uniprot Q10265 184
type: UnificationXref
id: Q10265
db: uniprot

uniprot A0A2I3TNT3 1117
type: UnificationXref
id: A0A2I3TNT3
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 96

uniprot Q6PH56 215
type: UnificationXref
id: Q6PH56
db: uniprot

ncbitaxon 9598 11
type: UnificationXref
id: 9598
db: ncbitaxon

Syntaxin-21
type: ProteinReference
xref: uniprot Q39233 384
organism: Arabidopsis thaliana

Tyrosine-protein kinase Blk
type: ProteinReference
xref: uniprot P51451 809
xref: PTHR24418:SF181
organism: Homo sapiens

Torsin
type: ProteinReference
xref: uniprot F6PGK6 450
xref: PTHR10760:SF15
organism: Monodelphis domestica

p38 MAPK
type: ProteinReference
xref: P01212
standard name: p38 mitogen activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.p38 MAPK
comment: ENTITY_REFERENCE_NOTES= Long Name: p38 MAPK Synonym: Synonym not specified Accession: P01212
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase 14B
member entity reference: Mitogen-activated protein kinase p38b

PTHR19375:SF184
type: RelationshipXref
id: PTHR19375:SF184
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot O08911 431
organism: Mus musculus

uniprot P40229 914
type: UnificationXref
id: P40229
db: uniprot

uniprot F7CYE3 427
type: UnificationXref
id: F7CYE3
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot E2R2N2 273
organism: Canis lupus familiaris

uniprot Q01959 738
type: UnificationXref
id: Q01959
db: uniprot

uniprot A9SDV6 537
type: UnificationXref
id: A9SDV6
db: uniprot

P01238
type: UnificationXref
id: P01238
db: PANTHER Pathway Component

uniprot F7DD51 91
type: UnificationXref
id: F7DD51
db: uniprot

ERK s70 a98 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

P01239
type: UnificationXref
id: P01239
db: PANTHER Pathway Component

uniprot F7A451 466
type: UnificationXref
id: F7A451
db: uniprot

P01236
type: UnificationXref
id: P01236
db: PANTHER Pathway Component

PTHR18860:SF7
type: RelationshipXref
id: PTHR18860:SF7
db: PANTHER Family
relationship type: By Homology

TH s100 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TH
stoichiometric coefficient: 1.0

uniprot Q9LKR3 247
type: UnificationXref
id: Q9LKR3
db: uniprot

P01237
type: UnificationXref
id: P01237
db: PANTHER Pathway Component

TH s100 sa34 rs1
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ub-_Complex__Parkin_Pael_R_-RIGHT__Complex__Parkin_Pael_R_-_r49
controller: CHIP

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF10
xref: uniprot F7ETB2 574
organism: Monodelphis domestica

PTHR18860:SF3
type: RelationshipXref
id: PTHR18860:SF3
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Cyclin_E-RIGHT__a119_degraded-_r52
controller: Complex (19S proteasome/20S proteasome)

Parkin s111 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

G1/S-specific cyclin-E1
type: ProteinReference
xref: uniprot Q61457 357
xref: PTHR10177:SF71
organism: Mus musculus

uniprot A0A0D1E7J2 963
type: UnificationXref
id: A0A0D1E7J2
db: uniprot

Cyclin E
type: Protein
entity reference: Cyclin E
feature: Cyclin E s89 a119 rs1
feature: ACTIVE 21
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F7GJZ7 780
type: UnificationXref
id: F7GJZ7
db: uniprot

P01242
type: UnificationXref
id: P01242
db: PANTHER Pathway Component

P01241
type: UnificationXref
id: P01241
db: PANTHER Pathway Component

P01240
type: UnificationXref
id: P01240
db: PANTHER Pathway Component

uniprot P12931 799
type: UnificationXref
id: P12931
db: uniprot

ncbitaxon 5786 70
type: UnificationXref
id: 5786
db: ncbitaxon

STATE_TRANSITION_LEFT__Complex__Synphilin_Parkin_-RIGHT__a92_degraded-_r42
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 1321
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 1320
left: Complex (Synphilin/Parkin)
interaction type: STATE_TRANSITION
right: a92_degraded

uniprot P34730 1013
type: UnificationXref
id: P34730
db: uniprot

Proteasome subunit alpha type-4
type: ProteinReference
xref: PTHR11599:SF13
xref: uniprot Q3ZCK9 673
organism: Bos taurus

Casein kinase 1-like protein 2
type: ProteinReference
xref: uniprot Q9CAI5 1188
xref: PTHR11909:SF409
organism: Arabidopsis thaliana

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 254

uniprot Q9SJG9 331
type: UnificationXref
id: Q9SJG9
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF181
xref: uniprot Q4KM97 817
organism: Rattus norvegicus

Torsin
type: ProteinReference
xref: uniprot O45271 456
xref: PTHR10760:SF2
organism: Caenorhabditis elegans

uniprot A0A2I3TEU6 346
type: UnificationXref
id: A0A2I3TEU6
db: uniprot

14-3-3-like protein GF14 mu
type: ProteinReference
xref: uniprot Q96299 1073
xref: PTHR18860:SF125
organism: Arabidopsis thaliana

uniprot P14234 800
type: UnificationXref
id: P14234
db: uniprot

Cytosolic heat shock protein 70, putative
type: ProteinReference
xref: uniprot A2DFX7 27
xref: PTHR19375:SF395
organism: Trichomonas vaginalis

14-3-3-like protein GF14-B
type: ProteinReference
xref: PTHR18860:SF101
xref: uniprot Q7XTE8 1070
organism: Oryza sativa

STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__a1_degraded-_r18
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 1292
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 1291
left: alpha-Synuclein
interaction type: STATE_TRANSITION
right: a1_degraded

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot P45983 432
organism: Homo sapiens

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P45984 433
organism: Homo sapiens

Proteasome subunit beta
type: ProteinReference
xref: PTHR11599:SF42
xref: uniprot H2QXV4 587
organism: Pan troglodytes

Os01g0198200 protein
type: ProteinReference
xref: uniprot Q5QMY9 1162
xref: PTHR11909:SF395
organism: Oryza sativa

Stress-70 protein, mitochondrial
type: ProteinReference
xref: uniprot P38647 162
xref: PTHR19375:SF184
organism: Mus musculus

Stress-70 protein, mitochondrial
type: ProteinReference
xref: uniprot P38646 161
xref: PTHR19375:SF184
organism: Homo sapiens

alpha-Synuclein
type: Protein
entity reference: alpha-Synuclein
feature: S129 alpha Synuclein s49 a69 rs1
feature: alpha Synuclein s49 a69 rs3
feature: alpha Synuclein s49 a69 rs4
feature: Y125 alpha Synuclein s49 a69 rs2
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot Q7PMD7 694
type: UnificationXref
id: Q7PMD7
db: uniprot

O C342 s131 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: O C342
stoichiometric coefficient: 1.0

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
type: ProteinReference
xref: PTHR10371:SF3
xref: uniprot Q9D6J6 955
organism: Mus musculus

Pael R s75 a101 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot K7CVS9 895
type: UnificationXref
id: K7CVS9
db: uniprot

uniprot Q6P3K7 1169
type: UnificationXref
id: Q6P3K7
db: uniprot

uniprot Q91Y86 443
type: UnificationXref
id: Q91Y86
db: uniprot

Heat shock protein 68
type: ProteinReference
xref: uniprot O97125 113
xref: PTHR19375:SF431
organism: Drosophila melanogaster

uniprot P08182 905
type: UnificationXref
id: P08182
db: uniprot

Casein kinase 1-like protein 6
type: ProteinReference
xref: uniprot Q8LPJ1 1179
xref: PTHR11909:SF316
organism: Arabidopsis thaliana

uniprot P97633 1159
type: UnificationXref
id: P97633
db: uniprot

Pael R s38 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pael-R
stoichiometric coefficient: 1.0

uniprot P04394 946
type: UnificationXref
id: P04394
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot Q3ZCM0 816
xref: PTHR24418:SF39
organism: Bos taurus

uniprot Q8BK63 1173
type: UnificationXref
id: Q8BK63
db: uniprot

Serine/threonine-protein kinase spe-6
type: ProteinReference
xref: PTHR11909:SF72
xref: uniprot Q95PZ9 1186
organism: Caenorhabditis elegans

uniprot Q9VK14 727
type: UnificationXref
id: Q9VK14
db: uniprot

Protein CBR-KIN-19
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot A8XX71 1121
organism: Caenorhabditis briggsae

Cullin 1
type: ProteinReference
xref: PTHR11932:SF81
xref: uniprot E2R1V2 1078
organism: Canis lupus familiaris

Casein kinase 1-like protein 4
type: ProteinReference
xref: PTHR11909:SF97
xref: uniprot Q8LPI7 1178
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r44 1316
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

uniprot O70435 606
type: UnificationXref
id: O70435
db: uniprot

uniprot P40232 916
type: UnificationXref
id: P40232
db: uniprot

TRANSCRIPTION
type: InteractionVocabulary

uniprot P45984 433
type: UnificationXref
id: P45984
db: uniprot

Tyrosine-protein kinase Yes
type: ProteinReference
xref: PTHR24418:SF90
xref: uniprot F1LM93 764
organism: Rattus norvegicus

Heat Shock Protein
type: ProteinReference
xref: PTHR19375:SF207
xref: uniprot O45246 106
organism: Caenorhabditis elegans

Ube2j2 protein
type: ProteinReference
xref: uniprot A9JTQ9 464
xref: PTHR24068:SF135
organism: Xenopus tropicalis

STATE_TRANSITION_LEFT__Complex__CDCrel_1_Parkin_-RIGHT__a173_degraded-_r70
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 1330
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 1331
left: Complex (CDCrel-1/Parkin)
interaction type: STATE_TRANSITION
right: a173_degraded

PARTICIPANT STOICHIOMETRY r44 1315
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

Stress-70 protein, mitochondrial
type: ProteinReference
xref: uniprot Q3ZCH0 194
xref: PTHR19375:SF184
organism: Bos taurus

PTHR13820:SF4
type: RelationshipXref
id: PTHR13820:SF4
db: PANTHER Family
relationship type: By Homology

PTHR13820:SF5
type: RelationshipXref
id: PTHR13820:SF5
db: PANTHER Family
relationship type: By Homology

Torsin
type: ProteinReference
xref: uniprot H2QXX6 453
xref: PTHR10760:SF4
organism: Pan troglodytes

uniprot A8X0R4 968
type: UnificationXref
id: A8X0R4
db: uniprot

uniprot F7H4X8 829
type: UnificationXref
id: F7H4X8
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r27
control type: INHIBITION
controller: UCH-L1

uniprot H2R3I7 588
type: UnificationXref
id: H2R3I7
db: uniprot

uniprot P68037 489
type: UnificationXref
id: P68037
db: uniprot

P01208
type: UnificationXref
id: P01208
db: PANTHER Pathway Component

Mitogen-activated protein kinase 19
type: ProteinReference
xref: uniprot Q9LUC3 328
organism: Arabidopsis thaliana

P01207
type: UnificationXref
id: P01207
db: PANTHER Pathway Component

P01209
type: UnificationXref
id: P01209
db: PANTHER Pathway Component

Mitogen-activated protein kinase spk1
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot P27638 293
organism: Schizosaccharomyces pombe

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 170

P01210
type: UnificationXref
id: P01210
db: PANTHER Pathway Component

uniprot F6PMD9 559
type: UnificationXref
id: F6PMD9
db: uniprot

P01211
type: UnificationXref
id: P01211
db: PANTHER Pathway Component

P01212
type: UnificationXref
id: P01212
db: PANTHER Pathway Component

P01213
type: UnificationXref
id: P01213
db: PANTHER Pathway Component

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF13
xref: uniprot Q7ZV77 704
organism: Danio rerio

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 250

F-box and WD repeat domain-containing 11
type: ProteinReference
xref: uniprot A0A0G2JVE0 1093
organism: Rattus norvegicus

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot F0Z724 552
xref: PTHR11599:SF12
organism: Dictyostelium purpureum

uniprot Q39027 307
type: UnificationXref
id: Q39027
db: uniprot

O-glyc
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s86 sa24 1236
cellular location: intracellular
comment: SPECIES_TYPE=ION

Proteasome subunit beta
type: ProteinReference
xref: uniprot F7EIY0 573
xref: PTHR11599:SF62
organism: Macaca mulatta

uniprot F5HEA9 276
type: UnificationXref
id: F5HEA9
db: uniprot

Septin 4, isoform A
type: ProteinReference
xref: uniprot Q0KHR7 516
organism: Drosophila melanogaster

alpha-Synuclein
type: ProteinReference
xref: P01218
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC._alpha_-Synuclein
comment: ENTITY_REFERENCE_NOTES= Long Name: alpha-Synuclein Synonym: Synonym not specified Accession: P01218
member entity reference: Alpha-synuclein

STATE_TRANSITION_LEFT__Complex__O_glyc_alpha_Synuclein__Parkin_-RIGHT__a148_degraded-_r58
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1362
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1363
left: Complex (O-glyc/alpha-Synuclein/ Parkin)
interaction type: STATE_TRANSITION
right: a148_degraded

Proteasome subunit beta type-10
type: ProteinReference
xref: PTHR11599:SF41
xref: uniprot Q4KM35 674
organism: Rattus norvegicus

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot A0A2I3SIH9 751
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot A0A1D5NXQ4 1113
organism: Gallus gallus

uniprot A0A3Q1M118 1097
type: UnificationXref
id: A0A3Q1M118
db: uniprot

P01219
type: UnificationXref
id: P01219
db: PANTHER Pathway Component

P01218
type: UnificationXref
id: P01218
db: PANTHER Pathway Component

P01217
type: UnificationXref
id: P01217
db: PANTHER Pathway Component

P01216
type: UnificationXref
id: P01216
db: PANTHER Pathway Component

P01215
type: UnificationXref
id: P01215
db: PANTHER Pathway Component

P01214
type: UnificationXref
id: P01214
db: PANTHER Pathway Component

P01223
type: UnificationXref
id: P01223
db: PANTHER Pathway Component

P01224
type: UnificationXref
id: P01224
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r2 1307
type: Stoichiometry
physical entity: MPTP
stoichiometric coefficient: 1.0

P01221
type: UnificationXref
id: P01221
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r2 1308
type: Stoichiometry
physical entity: MPP+
stoichiometric coefficient: 1.0

P01222
type: UnificationXref
id: P01222
db: PANTHER Pathway Component

P01220
type: UnificationXref
id: P01220
db: PANTHER Pathway Component

uniprot E2REA4 976
type: UnificationXref
id: E2REA4
db: uniprot

AGAP002645-PA
type: ProteinReference
xref: uniprot Q7QCI4 521
organism: Anopheles gambiae

STATE_TRANSITION_LEFT__Cyclin_E-RIGHT__a119_degraded-_r52
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 1388
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 1389
left: Cyclin E
interaction type: STATE_TRANSITION
right: a119_degraded

STATE_TRANSITION_LEFT__Complex__Parkin_Pael_R_-RIGHT__a109_degraded-_r50
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 1393
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 1392
left: Complex (Parkin/Pael-R)
interaction type: STATE_TRANSITION
right: a109_degraded

PTHR10760:SF15
type: RelationshipXref
id: PTHR10760:SF15
db: PANTHER Family
relationship type: By Homology

ACTIVE 21
type: EntityFeature
comment: Active state

PARTICIPANT STOICHIOMETRY r39 1332
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r39 1333
type: Stoichiometry
physical entity: H2O2
stoichiometric coefficient: 1.0

P01229
type: UnificationXref
id: P01229
db: PANTHER Pathway Component

F-box and WD repeat domain containing 11
type: ProteinReference
xref: uniprot F6YUQ2 1099
organism: Ornithorhynchus anatinus

P01226
type: UnificationXref
id: P01226
db: PANTHER Pathway Component

P01225
type: UnificationXref
id: P01225
db: PANTHER Pathway Component

P01228
type: UnificationXref
id: P01228
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot E9H8M4 979
organism: Daphnia pulex

P01227
type: UnificationXref
id: P01227
db: PANTHER Pathway Component

P01232
type: UnificationXref
id: P01232
db: PANTHER Pathway Component

P01233
type: UnificationXref
id: P01233
db: PANTHER Pathway Component

P01234
type: UnificationXref
id: P01234
db: PANTHER Pathway Component

P01235
type: UnificationXref
id: P01235
db: PANTHER Pathway Component

S129 alpha Synuclein s50 a70 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S129
feature location: S129 alpha Synuclein s50 a70 rs1 S129
comment: MODIFICATION_RESIDUE_NAME=S129
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

PTHR46803:SF2
type: RelationshipXref
id: PTHR46803:SF2
db: PANTHER Family
relationship type: By Homology

P01230
type: UnificationXref
id: P01230
db: PANTHER Pathway Component

P01231
type: UnificationXref
id: P01231
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__Complex__TH_Parkin_-RIGHT__a157_degraded-_r62
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 1349
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 1348
left: Complex (TH/Parkin)
interaction type: STATE_TRANSITION
right: a157_degraded

NADH-quinone oxidoreductase subunit E
type: ProteinReference
xref: uniprot P9WIV5 951
organism: Mycobacterium tuberculosis

PARTICIPANT STOICHIOMETRY r43 1319
type: Stoichiometry
physical entity: Complex (Synphilin/Parkin)
stoichiometric coefficient: 1.0

Complex (Synphilin/Parkin)
type: Complex
component stoichiometry: Synphilin s30 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: Parkin s33 sa10 STOICHIOMETRY ID COMPLEX
component: Synphilin
component: Parkin
feature: COMPLEX BINDING FEATURE s65 a90 1217
feature: COMPLEX BINDING FEATURE s65 a90 1215
cellular location: intracellular

PARTICIPANT STOICHIOMETRY r43 1318
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r43 1317
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

Cul 1 s45 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cul-1
stoichiometric coefficient: 1.0

Heat shock-related 70 kDa protein 2
type: ProteinReference
xref: uniprot P17156 139
xref: PTHR19375:SF382
organism: Mus musculus

S129 alpha Synuclein s87 sa25 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S129
feature location: S129 alpha Synuclein s87 sa25 rs1 S129
comment: MODIFICATION_RESIDUE_NAME=S129
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

PTHR11740:SF0
type: RelationshipXref
id: PTHR11740:SF0
db: PANTHER Family
relationship type: By Homology

Proteasome subunit alpha type-1
type: ProteinReference
xref: uniprot O44156 603
xref: PTHR11599:SF12
organism: Caenorhabditis elegans

Proteasome subunit alpha type-2
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot Q3T0Y5 671
organism: Bos taurus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63085 296
xref: PTHR24055:SF203
organism: Mus musculus

alpha Synuclein s4 sa6 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.528611247526151

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63086 297
xref: PTHR24055:SF203
organism: Rattus norvegicus

PTHR11740:SF5
type: RelationshipXref
id: PTHR11740:SF5
db: PANTHER Family
relationship type: By Homology

uniprot E2R6G0 395
type: UnificationXref
id: E2R6G0
db: uniprot

F-box and WD repeat domain containing 7
type: ProteinReference
xref: uniprot H2QQA2 1102
organism: Pan troglodytes

Septin-5
type: ProteinReference
xref: uniprot Q0VC68 517
xref: PTHR18884:SF68
organism: Bos taurus

uniprot A0A1D5PFJ6 22
type: UnificationXref
id: A0A1D5PFJ6
db: uniprot

Tyrosine-protein kinase CSK
type: ProteinReference
xref: uniprot P41240 805
xref: PTHR24418:SF407
organism: Homo sapiens

S129 alpha Synuclein s13 sa8 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S129
feature location: S129 alpha Synuclein s13 sa8 rs1 S129
comment: MODIFICATION_RESIDUE_NAME=S129
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

Tyrosine-protein kinase CSK
type: ProteinReference
xref: uniprot P41241 806
xref: PTHR24418:SF407
organism: Mus musculus

uniprot Q9Z238 358
type: UnificationXref
id: Q9Z238
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot P53778 436
organism: Homo sapiens

ncbitaxon 44689 159
type: UnificationXref
id: 44689
db: ncbitaxon

Casein kinase II subunit alpha
type: ProteinReference
xref: uniprot Q02720 923
xref: PTHR24054:SF0
organism: Dictyostelium discoideum

Mitogen-activated protein kinase 10
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot P53779 437
organism: Homo sapiens

Heat shock 70 kDa protein BIP2
type: ProteinReference
xref: uniprot Q53RJ5 204
xref: PTHR19375:SF442
organism: Oryza sativa

uniprot P68399 922
type: UnificationXref
id: P68399
db: uniprot

F-box and WD repeat domain containing 11
type: ProteinReference
xref: uniprot A0A3Q1M118 1097
organism: Bos taurus

Heat shock cognate 70
type: ProteinReference
xref: PTHR19375:SF426
xref: uniprot Q6PGX4 214
organism: Danio rerio

ncbitaxon 284591 239
type: UnificationXref
id: 284591
db: ncbitaxon

Casein kinase 1 delta
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot F6TBG4 1128
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r57 1366
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

14-3-3 protein beta/alpha
type: ProteinReference
xref: uniprot F6XFG9 987
xref: PTHR18860:SF28
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r57 1368
type: Stoichiometry
physical entity: Complex (O-glyc/alpha-Synuclein/ Parkin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r57 1367
type: Stoichiometry
physical entity: Complex (O-glyc/alpha-Synuclein)
stoichiometric coefficient: 1.0

alpha Synuclein s4 sa6 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Proteasome subunit alpha type-1
type: ProteinReference
xref: uniprot Q3T0X5 670
xref: PTHR11599:SF12
organism: Bos taurus

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF401
xref: uniprot O23236 287
organism: Arabidopsis thaliana

uniprot Q9RY23 249
type: UnificationXref
id: Q9RY23
db: uniprot

Syntaxin 7
type: ProteinReference
xref: PTHR19957:SF90
xref: uniprot F7E0A0 371
organism: Ornithorhynchus anatinus

uniprot E2RDD9 401
type: UnificationXref
id: E2RDD9
db: uniprot

PARTICIPANT STOICHIOMETRY r53 1386
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 1387
type: Stoichiometry
physical entity: Complex (N Y125/alpha-Synuclein)
stoichiometric coefficient: 1.0

26S proteasome regulatory subunit RPN9
type: ProteinReference
xref: uniprot Q04062 255
xref: PTHR10539:SF0
organism: Saccharomyces cerevisiae

Putative heat shock 70-related protein 1,mitochondrial
type: ProteinReference
xref: uniprot Q4Q747 199
xref: PTHR19375:SF184
organism: Leishmania major

Alpha-synuclein
type: ProteinReference
xref: uniprot Q9I9H1 407
xref: PTHR13820:SF5
organism: Gallus gallus

Synphilin s3 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Synphilin
stoichiometric coefficient: 1.0

Putative heat shock 70-related protein 1,mitochondrial
type: ProteinReference
xref: uniprot Q4Q745 198
xref: PTHR19375:SF184
organism: Leishmania major

Putative heat shock 70-related protein 1,mitochondrial
type: ProteinReference
xref: uniprot Q4Q744 197
xref: PTHR19375:SF184
organism: Leishmania major

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot A0A3Q1LWJ8 414
organism: Bos taurus

uniprot Q9Z2Q6 525
type: UnificationXref
id: Q9Z2Q6
db: uniprot

uniprot O76070 830
type: UnificationXref
id: O76070
db: uniprot

uniprot A0A2I3TWC0 258
type: UnificationXref
id: A0A2I3TWC0
db: uniprot

Putative heat shock 70-related protein 1,mitochondrial
type: ProteinReference
xref: uniprot Q4Q740 195
xref: PTHR19375:SF184
organism: Leishmania major

uniprot Q4Q747 199
type: UnificationXref
id: Q4Q747
db: uniprot

uniprot Q9WVS8 332
type: UnificationXref
id: Q9WVS8
db: uniprot

IDA
type: EvidenceCodeVocabulary

uniprot P36415 158
type: UnificationXref
id: P36415
db: uniprot

uniprot Q0VC68 517
type: UnificationXref
id: Q0VC68
db: uniprot

uniprot P68036 488
type: UnificationXref
id: P68036
db: uniprot

uniprot Q95083 711
type: UnificationXref
id: Q95083
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF168
xref: uniprot F6XFE0 85
organism: Monodelphis domestica

Ub
type: SmallMolecule
cellular location: intracellular
comment: SPECIES_TYPE=ION

ncbitaxon 10090 18
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot E2QX84 67
type: UnificationXref
id: E2QX84
db: uniprot

uniprot F0Z8D7 1079
type: UnificationXref
id: F0Z8D7
db: uniprot

Tyrosine-protein kinase CSK
type: ProteinReference
xref: uniprot Q0VBZ0 814
xref: PTHR24418:SF407
organism: Bos taurus

uniprot F6VPH2 1129
type: UnificationXref
id: F6VPH2
db: uniprot

70 kDa heat shock protein putative
type: ProteinReference
xref: uniprot C4M770 66
xref: PTHR19375:SF144
organism: Entamoeba histolytica

Uncharacterized protein
type: ProteinReference
xref: PTHR18884:SF68
xref: uniprot A0A1D5P321 496
organism: Gallus gallus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r44
controller: Casein kinase II

uniprot Q9UNE7 364
type: UnificationXref
id: Q9UNE7
db: uniprot

uniprot Q7Q2B0 698
type: UnificationXref
id: Q7Q2B0
db: uniprot

uniprot O08911 431
type: UnificationXref
id: O08911
db: uniprot

Heat shock cognate 70-kd protein, tandem duplicate 3
type: ProteinReference
xref: PTHR19375:SF448
xref: uniprot Q6PH56 215
organism: Danio rerio

uniprot P18334 906
type: UnificationXref
id: P18334
db: uniprot

G protein-coupled receptor 37 like 1
type: ProteinReference
xref: uniprot H2Q0W6 742
organism: Pan troglodytes

O glyc s91 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: O-glyc
stoichiometric coefficient: 1.0

uniprot H2R0G7 430
type: UnificationXref
id: H2R0G7
db: uniprot

Heat shock 70 kDa protein, mitochondrial
type: ProteinReference
xref: uniprot P22774 151
xref: PTHR19375:SF184
organism: Schizosaccharomyces pombe

Casein kinase II subunit beta
type: ProteinReference
xref: uniprot Q5ACW5 927
xref: PTHR11740:SF24
organism: Candida albicans

uniprot F6Y478 990
type: UnificationXref
id: F6Y478
db: uniprot

14-3-3 protein theta
type: ProteinReference
xref: PTHR18860:SF3
xref: uniprot Q5ZMD1 1061
organism: Gallus gallus

Proteasome subunit alpha type-7-1
type: ProteinReference
xref: uniprot P22769 623
xref: PTHR11599:SF15
organism: Drosophila melanogaster

Beta-synuclein
type: ProteinReference
xref: uniprot Q63754 399
xref: PTHR13820:SF4
organism: Rattus norvegicus

uniprot P22774 151
type: UnificationXref
id: P22774
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r1
control type: INHIBITION
controller: gamma-Synuclein

uniprot F7GTV9 452
type: UnificationXref
id: F7GTV9
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r1
controller: H2O2

Parkin s36 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

uniprot O45271 456
type: UnificationXref
id: O45271
db: uniprot

uniprot P26817 861
type: UnificationXref
id: P26817
db: uniprot

Complex I
type: ProteinReference
xref: P01237
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.Complex I
comment: ENTITY_REFERENCE_NOTES= Long Name: Complex I Synonym: Synonym not specified Accession: P01237
member entity reference: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
member entity reference: AGAP002170-PA
member entity reference: Probable NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
member entity reference: NuoE, NADH dehydrogenase subunit
member entity reference: NADH-quinone oxidoreductase subunit E
member entity reference: NADH dehydrogenase I, E subunit
member entity reference: NADH dehydrogenase (Ubiquinone) 24 kDa subunit, isoform A
member entity reference: AT21479p
member entity reference: NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial
member entity reference: NADP-reducing hydrogenase, subunit A
member entity reference: YALI0D00737p
member entity reference: Fe-hydrogenase, subunit gamma
member entity reference: Protein CBG11518
member entity reference: Uncharacterized protein

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F6X6I5 772
xref: PTHR24418:SF42
organism: Ornithorhynchus anatinus

Tyrosine-protein kinase HCK
type: ProteinReference
xref: PTHR24418:SF245
xref: uniprot P08103 795
organism: Mus musculus

uniprot Q5A397 207
type: UnificationXref
id: Q5A397
db: uniprot

uniprot E2R4Q2 369
type: UnificationXref
id: E2R4Q2
db: uniprot

Proteasome subunit beta
type: ProteinReference
xref: uniprot Q7ZUJ8 703
xref: PTHR11599:SF62
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR24054:SF16
xref: uniprot F6VCI6 891
organism: Monodelphis domestica

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Cyclin_E-RIGHT__Cyclin_E-_r51
controller: Complex (Cul-1/Parkin/ hSel10)

SAPK s72 a78 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F7H8A7 782
type: UnificationXref
id: F7H8A7
db: uniprot

uniprot F7F9Q9 893
type: UnificationXref
id: F7F9Q9
db: uniprot

Beta-synuclein
type: ProteinReference
xref: uniprot P33567 397
xref: PTHR13820:SF4
organism: Bos taurus

uniprot E2RF52 546
type: UnificationXref
id: E2RF52
db: uniprot

uniprot P17820 140
type: UnificationXref
id: P17820
db: uniprot

Mitogen-activated protein kinase 20
type: ProteinReference
xref: uniprot Q9SJG9 331
organism: Arabidopsis thaliana

uniprot Q8X077 708
type: UnificationXref
id: Q8X077
db: uniprot

Proteasome subunit alpha type-7-B
type: ProteinReference
xref: PTHR11599:SF183
xref: uniprot O24616 600
organism: Arabidopsis thaliana

uniprot A0A2J8Q2A9 497
type: UnificationXref
id: A0A2J8Q2A9
db: uniprot

uniprot O42766 1006
type: UnificationXref
id: O42766
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 209

uniprot Q585X3 206
type: UnificationXref
id: Q585X3
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF42
xref: uniprot E2RBB8 760
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLD2-RIGHT__PLD2-_r12
controller: alpha-Synuclein

uniprot F6UTP2 770
type: UnificationXref
id: F6UTP2
db: uniprot

Casein kinase 2 beta
type: ProteinReference
xref: uniprot A0A2I3TLD4 869
xref: PTHR11740:SF0
organism: Pan troglodytes

14-3-3 protein gamma
type: ProteinReference
xref: uniprot F6XLR8 988
xref: PTHR18860:SF22
organism: Macaca mulatta

Syntaxin-22
type: ProteinReference
xref: uniprot P93654 383
organism: Arabidopsis thaliana

Protein CBG11518
type: ProteinReference
xref: uniprot A8XCT2 943
xref: PTHR10371:SF3
organism: Caenorhabditis briggsae

14-3-3 protein zeta/delta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot P63103 1033
organism: Bos taurus

S129 alpha Synuclein s40 a57 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S129
feature location: S129 alpha Synuclein s40 a57 rs1 S129
comment: MODIFICATION_RESIDUE_NAME=S129
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

14-3-3 protein zeta/delta
type: ProteinReference
xref: uniprot P63104 1034
xref: PTHR18860:SF7
organism: Homo sapiens

uniprot Q4Q740 195
type: UnificationXref
id: Q4Q740
db: uniprot

ncbitaxon 35128 63
type: UnificationXref
id: 35128
db: ncbitaxon

uniprot F1MJ55 887
type: UnificationXref
id: F1MJ55
db: uniprot

14-3-3 protein zeta/delta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot P63102 1032
organism: Rattus norvegicus

14-3-3 protein zeta/delta
type: ProteinReference
xref: uniprot P63101 1031
xref: PTHR18860:SF7
organism: Mus musculus

uniprot F0Z8A7 886
type: UnificationXref
id: F0Z8A7
db: uniprot

Casein kinase 1-like protein 7
type: ProteinReference
xref: PTHR11909:SF366
xref: uniprot Q9FFH8 1190
organism: Arabidopsis thaliana

Cyclin E2
type: ProteinReference
xref: PTHR10177:SF70
xref: uniprot D3ZQ41 348
organism: Rattus norvegicus

uniprot P27638 293
type: UnificationXref
id: P27638
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q7ZVK8 317
xref: PTHR24055:SF393
organism: Danio rerio

14-3-3 protein theta
type: ProteinReference
xref: PTHR18860:SF3
xref: uniprot P68255 1037
organism: Rattus norvegicus

F-box/WD repeat-containing protein 7
type: ProteinReference
xref: uniprot Q969H0 1105
organism: Homo sapiens

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 117

uniprot P34120 638
type: UnificationXref
id: P34120
db: uniprot

14-3-3 protein theta
type: ProteinReference
xref: uniprot P68254 1036
xref: PTHR18860:SF3
organism: Mus musculus

CDCrel 1 s118 sa40 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 114

uniprot Q9P419 445
type: UnificationXref
id: Q9P419
db: uniprot

uniprot A0A2I3TLD4 869
type: UnificationXref
id: A0A2I3TLD4
db: uniprot

uniprot A8X7H4 47
type: UnificationXref
id: A8X7H4
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot F7DXH6 775
organism: Xenopus tropicalis

14-3-3 protein beta/alpha
type: ProteinReference
xref: uniprot P68250 1035
xref: PTHR18860:SF28
organism: Bos taurus

uniprot P19234 948
type: UnificationXref
id: P19234
db: uniprot

PARTICIPANT STOICHIOMETRY r27 1361
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

SAPK
type: Protein
entity reference: SAPK
feature: SAPK s56 a79 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r27 1360
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

uniprot P40234 1148
type: UnificationXref
id: P40234
db: uniprot

Torsin-2A
type: ProteinReference
xref: uniprot Q8R1J9 460
xref: PTHR10760:SF4
organism: Mus musculus

Cytosolic heat shock protein 70, putative
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot A2E1L2 28
organism: Trichomonas vaginalis

uniprot O45246 106
type: UnificationXref
id: O45246
db: uniprot

uniprot Q967X2 942
type: UnificationXref
id: Q967X2
db: uniprot

Mitogen-activated protein kinase KSS1
type: ProteinReference
xref: uniprot P14681 289
organism: Saccharomyces cerevisiae

Proteasome subunit beta
type: ProteinReference
xref: uniprot Q7PY13 697
xref: PTHR11599:SF62
organism: Anopheles gambiae

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A0A1D5PXC6 411
organism: Gallus gallus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A8X1S0 417
xref: PTHR24055:SF341
organism: Caenorhabditis briggsae

Casein kinase 1 alpha 1
type: ProteinReference
xref: PTHR11909:SF84
xref: uniprot A0A2I3RLP7 1115
organism: Pan troglodytes

uniprot C8VU45 1077
type: UnificationXref
id: C8VU45
db: uniprot

uniprot A0A2J8MKA4 964
type: UnificationXref
id: A0A2J8MKA4
db: uniprot

Ubiquitin carboxyl-terminal hydrolase isozyme L1
type: ProteinReference
xref: PTHR10589:SF19
xref: uniprot P09936 260
organism: Homo sapiens

uniprot Q28DR3 1046
type: UnificationXref
id: Q28DR3
db: uniprot

ERK
type: Protein
entity reference: ERK
feature: ACTIVE 21
feature: ERK s71 a96 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot Q6P023 314
organism: Danio rerio

uniprot Q99170 238
type: UnificationXref
id: Q99170
db: uniprot

uniprot P93654 383
type: UnificationXref
id: P93654
db: uniprot

Luminal-binding protein 2
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot Q8T869 232
organism: Dictyostelium discoideum

Heat shock-related 70 kDa protein 2
type: ProteinReference
xref: uniprot P14659 135
xref: PTHR19375:SF382
organism: Rattus norvegicus

ERK s71 a96 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F6XW91 989
type: UnificationXref
id: F6XW91
db: uniprot

Cullin homolog 1
type: ProteinReference
xref: uniprot Q24311 1090
xref: PTHR11932:SF81
organism: Drosophila melanogaster

Proteasome subunit alpha type-1
type: ProteinReference
xref: PTHR11599:SF12
xref: uniprot Q27562 660
organism: Dictyostelium discoideum

uniprot P53779 437
type: UnificationXref
id: P53779
db: uniprot

Proteasome subunit alpha type-3
type: ProteinReference
xref: PTHR11599:SF10
xref: uniprot Q27563 661
organism: Dictyostelium discoideum

ncbitaxon 6238 46
type: UnificationXref
id: 6238
db: ncbitaxon

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1P630 419
xref: PTHR24055:SF172
organism: Canis lupus familiaris

Sodium-dependent dopamine transporter
type: DnaReference
xref: PTHR11616:SF38
organism: Homo sapiens

Casein kinase I isoform alpha-like
type: ProteinReference
xref: uniprot Q8N752 1180
xref: PTHR11909:SF139
organism: Homo sapiens

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 51

Casein kinase I homolog 2
type: ProteinReference
xref: uniprot P23292 1142
xref: PTHR11909:SF155
organism: Saccharomyces cerevisiae

Beta-adrenergic receptor kinase 2
type: ProteinReference
xref: PTHR24355:SF17
xref: uniprot P35626 864
organism: Homo sapiens

19S proteasome s25 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 19S proteasome
stoichiometric coefficient: 1.0

Complex (14-3-3/alpha-Synuclein)
type: Complex
component stoichiometry: alpha Synuclein s13 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: 14 3 3 s11 sa7 STOICHIOMETRY ID COMPLEX
component: alpha-Synuclein
component: 14-3-3
feature: COMPLEX BINDING FEATURE s48 a68 1267
feature: COMPLEX BINDING FEATURE s48 a68 1265
cellular location: intracellular

uniprot Q9WTU6 446
type: UnificationXref
id: Q9WTU6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__L_tyrosine-RIGHT__L_DOPA-_r61
controller: TH

Proteasome subunit alpha type-1-A
type: ProteinReference
xref: PTHR11599:SF12
xref: uniprot P34066 636
organism: Arabidopsis thaliana

Proteasome subunit alpha type-5
type: ProteinReference
xref: uniprot P34064 635
xref: PTHR11599:SF14
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot H2R0G7 430
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF457
xref: uniprot H3E674 101
organism: Pristionchus pacificus

Alpha-synuclein
type: ProteinReference
xref: uniprot P37840 404
xref: PTHR13820:SF5
organism: Homo sapiens

uniprot F6WR53 771
type: UnificationXref
id: F6WR53
db: uniprot

uniprot P45983 432
type: UnificationXref
id: P45983
db: uniprot

uniprot Q06486 1160
type: UnificationXref
id: Q06486
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r1
controller: Fatty acids

uniprot P0A6Y8 119
type: UnificationXref
id: P0A6Y8
db: uniprot

uniprot B1WBY1 1076
type: UnificationXref
id: B1WBY1
db: uniprot

uniprot C8V7D1 271
type: UnificationXref
id: C8V7D1
db: uniprot

STATE_TRANSITION_LEFT__Elk_1-RIGHT__Elk_1-_r35
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 1343
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 1344
left: Elk-1
interaction type: STATE_TRANSITION
right: Elk-1

PTHR19375:SF223
type: RelationshipXref
id: PTHR19375:SF223
db: PANTHER Family
relationship type: By Homology

uniprot P18053 615
type: UnificationXref
id: P18053
db: uniprot

uniprot Q6P647 1170
type: UnificationXref
id: Q6P647
db: uniprot

uniprot Q9Y6M4 1201
type: UnificationXref
id: Q9Y6M4
db: uniprot

Phospholipase D2
type: ProteinReference
xref: uniprot P70498 15
xref: PTHR18896:SF121
organism: Rattus norvegicus

Chaperone protein DnaK
type: ProteinReference
xref: uniprot P61443 169
xref: PTHR19375:SF184
organism: Leptospira interrogans

Predicted protein
type: ProteinReference
xref: uniprot A9T4Y7 875
xref: PTHR24054:SF0
organism: Physcomitrella patens

STIP1 homology and U box-containing protein 1
type: ProteinReference
xref: PTHR46803:SF2
xref: uniprot Q9WUD1 365
organism: Mus musculus

H2O2
type: SmallMolecule
cellular location: mitochondrion
comment: SPECIES_TYPE=SIMPLE_MOLECULE

14-3-3-like protein GF14 omicron
type: ProteinReference
xref: PTHR18860:SF31
xref: uniprot Q9S9Z8 1075
organism: Arabidopsis thaliana

AGAP002076-PA
type: ProteinReference
xref: PTHR19375:SF457
xref: uniprot A7UVK8 38
organism: Anopheles gambiae

C-term of Hsp70-iNteracting protein (CHIP family)
type: ProteinReference
xref: PTHR46803:SF2
xref: uniprot G5ECY6 362
organism: Caenorhabditis elegans

Proto-oncogene tyrosine-protein kinase Src
type: ProteinReference
xref: uniprot Q9WUD9 827
xref: PTHR24418:SF53
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__Complex__CDCrel_1_Parkin_-RIGHT__Complex__CDCrel_1_Parkin_-_r69
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 1337
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 1336
left: Complex (CDCrel-1/Parkin)
interaction type: STATE_TRANSITION
right: Complex (CDCrel-1/Parkin)

uniprot F7CJA4 493
type: UnificationXref
id: F7CJA4
db: uniprot

Proteasome subunit alpha type-5
type: ProteinReference
xref: PTHR11599:SF14
xref: uniprot Q95083 711
organism: Drosophila melanogaster

PTHR19375:SF254
type: RelationshipXref
id: PTHR19375:SF254
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6TKL3 421
organism: Xenopus tropicalis

uniprot Q8H1B3 224
type: UnificationXref
id: Q8H1B3
db: uniprot

uniprot Q9R0P9 262
type: UnificationXref
id: Q9R0P9
db: uniprot

uniprot F7E0Z1 372
type: UnificationXref
id: F7E0Z1
db: uniprot

uniprot P29844 155
type: UnificationXref
id: P29844
db: uniprot

uniprot H2R3C4 510
type: UnificationXref
id: H2R3C4
db: uniprot

uniprot F7C9K3 570
type: UnificationXref
id: F7C9K3
db: uniprot

uniprot P48347 1020
type: UnificationXref
id: P48347
db: uniprot

uniprot F6WVD0 892
type: UnificationXref
id: F6WVD0
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot Q9LV37 329
organism: Arabidopsis thaliana

Parkin
type: Protein
entity reference: Parkin
feature: COMPLEX PARTICIPANT BINDING FEATURE s96 sa31 1234
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Casein kinase II subunit alpha
type: ProteinReference
xref: uniprot P21868 910
xref: PTHR24054:SF16
organism: Gallus gallus

14-3-3 protein theta
type: ProteinReference
xref: PTHR18860:SF3
xref: uniprot Q3SZI4 1048
organism: Bos taurus

uniprot H2XVD5 590
type: UnificationXref
id: H2XVD5
db: uniprot

uniprot H3FYW1 103
type: UnificationXref
id: H3FYW1
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
type: ProteinReference
xref: uniprot H2QHF1 1001
xref: PTHR18860:SF3
organism: Pan troglodytes

uniprot Q6Z7B0 216
type: UnificationXref
id: Q6Z7B0
db: uniprot

Stress-70 protein, mitochondrial
type: ProteinReference
xref: uniprot Q5ZM98 210
xref: PTHR19375:SF184
organism: Gallus gallus

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF90
xref: uniprot F7G374 779
organism: Monodelphis domestica

uniprot Q336R6 925
type: UnificationXref
id: Q336R6
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot F7DY42 995
organism: Xenopus tropicalis

Ubiquitin-conjugating enzyme E2 J2
type: ProteinReference
xref: uniprot Q6P073 469
xref: PTHR24068:SF135
organism: Mus musculus

uniprot P25788 630
type: UnificationXref
id: P25788
db: uniprot

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF17
xref: uniprot F7HT93 856
organism: Macaca mulatta

uniprot F0ZNQ2 553
type: UnificationXref
id: F0ZNQ2
db: uniprot

uniprot E2R1V2 1078
type: UnificationXref
id: E2R1V2
db: uniprot

uniprot Q2NKY7 519
type: UnificationXref
id: Q2NKY7
db: uniprot

uniprot P40233 1147
type: UnificationXref
id: P40233
db: uniprot

alpha-Synuclein
type: Protein
entity reference: alpha-Synuclein
feature: S129 alpha Synuclein s18 a21 rs1
feature: alpha Synuclein s18 a21 rs3
feature: alpha Synuclein s18 a21 rs4
feature: Y125 alpha Synuclein s18 a21 rs2
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q384Q5 192
type: UnificationXref
id: Q384Q5
db: uniprot

uniprot A2EP28 32
type: UnificationXref
id: A2EP28
db: uniprot

Hsp70
type: ProteinReference
xref: P01208
standard name: Heat shock protein 70
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.Hsp70
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Heat shock protein 70 Synonym: Synonym not specified Accession: P01208
member entity reference: Heat shock 70 kDa protein cognate 2
member entity reference: Heat shock-related 70 kDa protein 2
member entity reference: Heat shock cognate 71 kDa protein
member entity reference: Cytosolic heat shock protein 70, putative
member entity reference: Chaperone protein dnaK3
member entity reference: Uncharacterized protein
member entity reference: Heat shock protein SSA2
member entity reference: Putative heat shock 70-related protein 1,mitochondrial
member entity reference: Cytoplasmic heat shock protein 70, putative
member entity reference: Heat shock cognate 70-kd protein, tandem duplicate 3
member entity reference: Major heat shock 70 kDa protein Bbb
member entity reference: Heat shock protein family A (Hsp70) member 8
member entity reference: Heat shock 70 kDa protein 10, mitochondrial
member entity reference: Chaperone protein DnaK
member entity reference: Ribosome-associated molecular chaperone sks2
member entity reference: Heat shock 70 kDa protein C
member entity reference: AGAP010876-PA (Fragment)
member entity reference: Heat shock 70 kDa protein 3
member entity reference: Glucose-regulated protein 78, putative
member entity reference: Heat shock protein 70-related protein
member entity reference: Heat shock protein SSA1
member entity reference: Heat shock 70 kDa protein cognate 5
member entity reference: Stress-70 protein, mitochondrial
member entity reference: Heat shock protein 70 putative
member entity reference: Cytosolic HSP70
member entity reference: 78 kDa glucose-regulated protein
member entity reference: Endoplasmic reticulum chaperone BiP
member entity reference: Putative heat-shock protein hsp70
member entity reference: Ribosome-associated molecular chaperone SSB1
member entity reference: Ribosome-associated molecular chaperone SSB2
member entity reference: Heat shock 70 kDa protein, mitochondrial
member entity reference: Heat shock protein 70
member entity reference: Heat shock 70 kDa protein F, mitochondrial
member entity reference: Heat shock protein SSC3, mitochondrial
member entity reference: Heat shock 70 kDa protein 6
member entity reference: Probable heat shock protein ssa1
member entity reference: Heat shock 70 kDa protein 7, chloroplastic
member entity reference: Heat Shock Protein
member entity reference: HSPA8 isoform 16
member entity reference: Heat shock protein 70B
member entity reference: AGAP004944-PA
member entity reference: Heat shock 70 kDa protein cognate 4
member entity reference: Heat shock 70kDa protein
member entity reference: Predicted protein
member entity reference: Hsp70, putative (Fragment)
member entity reference: Mediator of RNA polymerase II transcription subunit 37a
member entity reference: Heat shock 70 kDa protein 1A
member entity reference: Cytoplasmic heat shock protein 70
member entity reference: Si:dkey-4p15.3
member entity reference: 70 kDa heat shock protein putative

uniprot Q63544 832
type: UnificationXref
id: Q63544
db: uniprot

uniprot Q6P6U0 821
type: UnificationXref
id: Q6P6U0
db: uniprot

PTHR11932:SF81
type: RelationshipXref
id: PTHR11932:SF81
db: PANTHER Family
relationship type: By Homology

Syntaxin-12
type: ProteinReference
xref: PTHR19957:SF88
xref: uniprot G3V7P1 374
organism: Rattus norvegicus

uniprot H2QU08 391
type: UnificationXref
id: H2QU08
db: uniprot

Casein kinase I isoform epsilon
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot P49674 1154
organism: Homo sapiens

uniprot F1P630 419
type: UnificationXref
id: F1P630
db: uniprot

ncbitaxon 10116 16
type: UnificationXref
id: 10116
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r26 1365
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 8.0

PARTICIPANT STOICHIOMETRY r26 1364
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

uniprot Q4Q0B0 308
type: UnificationXref
id: Q4Q0B0
db: uniprot

uniprot P19419 848
type: UnificationXref
id: P19419
db: uniprot

Syntaxin s129 sa45 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Syntaxin
stoichiometric coefficient: 1.0

14-3-3-like protein 2
type: ProteinReference
xref: PTHR18860:SF106
xref: uniprot Q20655 1045
organism: Caenorhabditis elegans

uniprot F6V735 451
type: UnificationXref
id: F6V735
db: uniprot

hSel10 s54 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: hSel10
stoichiometric coefficient: 1.0

uniprot P39949 355
type: UnificationXref
id: P39949
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot G5ECU5 95
organism: Caenorhabditis elegans

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 61

HETERODIMER_ASSOCIATION_LEFT__Pael_R-_Parkin-RIGHT__Complex__Parkin_Pael_R_-_r48
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1298
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1296
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1297
left: Parkin
left: Pael-R
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Parkin/Pael-R)

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F7GJZ7 780
xref: PTHR24418:SF407
organism: Monodelphis domestica

uniprot Q39043 193
type: UnificationXref
id: Q39043
db: uniprot

14-3-3 protein 3
type: ProteinReference
xref: PTHR18860:SF106
xref: uniprot C4M0F4 973
organism: Entamoeba histolytica

uniprot Q53NM9 203
type: UnificationXref
id: Q53NM9
db: uniprot

uniprot A2EKF3 31
type: UnificationXref
id: A2EKF3
db: uniprot

Mitogen-activated protein kinase hog1
type: ProteinReference
xref: uniprot Q9P419 445
organism: Emericella nidulans

Putative glucose-regulated protein 78
type: ProteinReference
xref: uniprot Q4Q8E6 201
xref: PTHR19375:SF144
organism: Leishmania major

uniprot F1LM93 764
type: UnificationXref
id: F1LM93
db: uniprot

uniprot A0A2I3TBD9 828
type: UnificationXref
id: A0A2I3TBD9
db: uniprot

uniprot Q9ER00 388
type: UnificationXref
id: Q9ER00
db: uniprot

Proteasome subunit beta type-3
type: ProteinReference
xref: uniprot Q23237 657
xref: PTHR11599:SF62
organism: Caenorhabditis elegans

14 3 3 s11 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 14-3-3
stoichiometric coefficient: 1.0

Proteasome subunit alpha type-7-1B
type: ProteinReference
xref: uniprot Q27575 662
xref: PTHR11599:SF15
organism: Drosophila melanogaster

uniprot Q01525 1041
type: UnificationXref
id: Q01525
db: uniprot

Synphilin-1
type: ProteinReference
xref: PTHR22882:SF3
xref: uniprot Q9Y6H5 495
organism: Homo sapiens

uniprot A8B431 39
type: UnificationXref
id: A8B431
db: uniprot

uniprot Q8II24 228
type: UnificationXref
id: Q8II24
db: uniprot

uniprot Q7QK63 447
type: UnificationXref
id: Q7QK63
db: uniprot

Pael R s44 sa16 rs1
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

14-3-3 protein
type: ProteinReference
xref: uniprot A8JGV6 967
xref: PTHR18860:SF115
organism: Chlamydomonas reinhardtii

ncbitaxon 6669 884
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot O35955 601
type: UnificationXref
id: O35955
db: uniprot

PARTICIPANT STOICHIOMETRY r70 1330
type: Stoichiometry
physical entity: Complex (CDCrel-1/Parkin)
stoichiometric coefficient: 1.0

alpha Synuclein s39 a56 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.528611247526151

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q9LM33 325
organism: Arabidopsis thaliana

uniprot H2QLJ0 1002
type: UnificationXref
id: H2QLJ0
db: uniprot

PARTICIPANT STOICHIOMETRY r70 1331
type: Stoichiometry
physical entity: a173_degraded
stoichiometric coefficient: 1.0

Synphilin
type: Protein
entity reference: Synphilin
feature: Synphilin s3 sa5 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa5 1262
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q99ME3 494
type: UnificationXref
id: Q99ME3
db: uniprot

uniprot Q9S9N1 251
type: UnificationXref
id: Q9S9N1
db: uniprot

uniprot Q22033 1161
type: UnificationXref
id: Q22033
db: uniprot

Casein kinase II subunit beta
type: ProteinReference
xref: uniprot P43639 917
xref: PTHR11740:SF24
organism: Saccharomyces cerevisiae

Proteasome subunit beta
type: ProteinReference
xref: uniprot F6S2Q4 561
xref: PTHR11599:SF62
organism: Monodelphis domestica

AGAP001683-PA
type: ProteinReference
xref: uniprot A0NGZ6 837
xref: PTHR23122:SF7
organism: Anopheles gambiae

uniprot Q9WVS6 393
type: UnificationXref
id: Q9WVS6
db: uniprot

alpha Synuclein s39 a56 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Chaperone protein DnaK
type: ProteinReference
xref: uniprot Q9RY23 249
xref: PTHR19375:SF184
organism: Deinococcus radiodurans

uniprot Q5Z859 312
type: UnificationXref
id: Q5Z859
db: uniprot

STATE_TRANSITION_LEFT__DAT-RIGHT__Complex__DAT_O_C342_-_r72
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 1326
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 1325
left: DAT
interaction type: STATE_TRANSITION
right: Complex (DAT/O C342)

SAPK
type: Protein
entity reference: SAPK
feature: SAPK s72 a78 rs1
feature: ACTIVE 21
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ub-_Complex__Parkin_Pael_R_-RIGHT__Complex__Parkin_Pael_R_-_r49
controller: Ubc7

uniprot F6UZ27 81
type: UnificationXref
id: F6UZ27
db: uniprot

CCNE2 isoform 1
type: ProteinReference
xref: PTHR10177:SF70
xref: uniprot H2R9R9 352
organism: Pan troglodytes

Heat shock 70 kDa protein
type: ProteinReference
xref: PTHR19375:SF426
xref: uniprot Q01233 181
organism: Neurospora crassa

Parkin
type: ProteinReference
xref: P01216
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Parkin Synonym: Synonym not specified Accession: P01216
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.Parkin
member entity reference: E3 ubiquitin-protein ligase parkin

Mitogen-activated protein kinase 15
type: ProteinReference
xref: uniprot Q9C9U4 323
organism: Arabidopsis thaliana

MPTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Heat shock cognate 71 kDa protein
type: ProteinReference
xref: PTHR19375:SF457
xref: uniprot Q90473 235
organism: Danio rerio

uniprot P40228 913
type: UnificationXref
id: P40228
db: uniprot

uniprot P41932 1015
type: UnificationXref
id: P41932
db: uniprot

uniprot Q99719 524
type: UnificationXref
id: Q99719
db: uniprot

Casein kinase I isoform gamma-3
type: ProteinReference
xref: uniprot Q9Y6M4 1201
xref: PTHR11909:SF151
organism: Homo sapiens

hSel10
type: Protein
entity reference: hSel10
feature: COMPLEX PARTICIPANT BINDING FEATURE s54 sa19 1252
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6R8N9 278
xref: PTHR24055:SF79
organism: Macaca mulatta

CASK
type: ProteinReference
xref: P01232
standard name: Calcium/calmodulin-dependent serine protein kinase
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.CASK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Calcium/calmodulin-dependent serine protein kinase Synonym: Synonym not specified Accession: P01232
member entity reference: Protein lin-2
member entity reference: CASK isoform 4
member entity reference: Peripheral plasma membrane protein CASK
member entity reference: Uncharacterized protein
member entity reference: Calcium/calmodulin-dependent serine protein kinase (MAGUK family)
member entity reference: AGAP001683-PA
member entity reference: Protein CBR-LIN-2

DAT
type: ProteinReference
xref: P01228
standard name: Dopamine transporter
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.DAT
comment: ENTITY_REFERENCE_NOTES= Long Name: Dopamine transporter Synonym: Synonym not specified Accession: P01228
member entity reference: Sodium-dependent dopamine transporter
member entity reference: Transporter

14-3-3 protein, putative
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot Q5K8Z6 1053
organism: Cryptococcus neoformans

Heat shock protein family A (Hsp70) member 2
type: ProteinReference
xref: uniprot F6ZXI7 87
xref: PTHR19375:SF382
organism: Ornithorhynchus anatinus

uniprot Q61831 440
type: UnificationXref
id: Q61831
db: uniprot

DAT s130 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DAT
stoichiometric coefficient: 1.0

uniprot F1PIC7 72
type: UnificationXref
id: F1PIC7
db: uniprot

uniprot P35213 1014
type: UnificationXref
id: P35213
db: uniprot

Casein kinase I homolog 3
type: ProteinReference
xref: uniprot O74135 1139
xref: PTHR11909:SF155
organism: Schizosaccharomyces pombe

uniprot P34931 157
type: UnificationXref
id: P34931
db: uniprot

uniprot Q9XZJ4 732
type: UnificationXref
id: Q9XZJ4
db: uniprot

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 244

14-3-3 protein beta/alpha
type: ProteinReference
xref: PTHR18860:SF28
xref: uniprot Q5ZLQ6 1060
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CJA4 493
xref: PTHR22882:SF3
organism: Macaca mulatta

uniprot Q6L509 212
type: UnificationXref
id: Q6L509
db: uniprot

uniprot Q5B4M9 1049
type: UnificationXref
id: Q5B4M9
db: uniprot

uniprot Q27562 660
type: UnificationXref
id: Q27562
db: uniprot

uniprot P04177 1109
type: UnificationXref
id: P04177
db: uniprot

14-3-3 protein gamma
type: ProteinReference
xref: uniprot A7Z057 966
xref: PTHR18860:SF22
organism: Bos taurus

uniprot O64816 898
type: UnificationXref
id: O64816
db: uniprot

SAPK s56 a79 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q3T0X5 670
type: UnificationXref
id: Q3T0X5
db: uniprot

Cullin-1
type: ProteinReference
xref: PTHR11932:SF81
xref: uniprot Q9WTX6 1092
organism: Mus musculus

Proteasome subunit beta type-7
type: ProteinReference
xref: PTHR11599:SF42
xref: uniprot Q99436 712
organism: Homo sapiens

PTHR24068:SF135
type: RelationshipXref
id: PTHR24068:SF135
db: PANTHER Family
relationship type: By Homology

CDCrel 1 s107 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CDCrel-1
stoichiometric coefficient: 1.0

uniprot F6R2T7 1126
type: UnificationXref
id: F6R2T7
db: uniprot

alpha-Synuclein
type: Protein
entity reference: alpha-Synuclein
feature: alpha Synuclein s2 a2 rs4
feature: alpha Synuclein s2 a2 rs3
feature: S129 alpha Synuclein s2 a2 rs1
feature: Y125 alpha Synuclein s2 a2 rs2

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r44
controller: Casein kinase I

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF10
xref: uniprot H2Q8D7 582
organism: Pan troglodytes

ONOO-
type: SmallMolecule
cellular location: intracellular
comment: SPECIES_TYPE=ION

uniprot G5ECY6 362
type: UnificationXref
id: G5ECY6
db: uniprot

uniprot P62258 1027
type: UnificationXref
id: P62258
db: uniprot

uniprot H2RGT2 454
type: UnificationXref
id: H2RGT2
db: uniprot

Casein kinase II subunit alpha
type: ProteinReference
xref: uniprot P18334 906
xref: PTHR24054:SF0
organism: Caenorhabditis elegans

uniprot Q9R1P0 720
type: UnificationXref
id: Q9R1P0
db: uniprot

Casein kinase II subunit alpha'
type: ProteinReference
xref: uniprot P19454 908
xref: PTHR24054:SF27
organism: Saccharomyces cerevisiae

uniprot H2REV2 1134
type: UnificationXref
id: H2REV2
db: uniprot

Similar to Ubc6p homolog, isoform CRA_a
type: ProteinReference
xref: uniprot A0A0G2K8C5 463
xref: PTHR24068:SF135
organism: Rattus norvegicus

uniprot H3FT78 1135
type: UnificationXref
id: H3FT78
db: uniprot

Heat shock 70 kDa protein cognate 5
type: ProteinReference
xref: uniprot P29845 156
xref: PTHR19375:SF184
organism: Drosophila melanogaster

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: uniprot P29844 155
xref: PTHR19375:SF144
organism: Drosophila melanogaster

uniprot Q5JU69 457
type: UnificationXref
id: Q5JU69
db: uniprot

Heat shock 70 kDa protein cognate 1
type: ProteinReference
xref: PTHR19375:SF457
xref: uniprot P29843 154
organism: Drosophila melanogaster

uniprot Q640S9 819
type: UnificationXref
id: Q640S9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QVF6 835
xref: PTHR23122:SF40
organism: Macaca mulatta

uniprot Q9W470 730
type: UnificationXref
id: Q9W470
db: uniprot

uniprot P09936 260
type: UnificationXref
id: P09936
db: uniprot

uniprot Q21633 477
type: UnificationXref
id: Q21633
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E0Z1 372
xref: PTHR19957:SF90
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RHZ1 881
xref: PTHR24054:SF16
organism: Canis lupus familiaris

Heat shock 70 kDa protein 5
type: ProteinReference
xref: PTHR19375:SF436
xref: uniprot Q9S9N1 251
organism: Arabidopsis thaliana

Synphilin s34 sa11 rs1
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot Q24311 1090
type: UnificationXref
id: Q24311
db: uniprot

Probable proteasome subunit beta type-2
type: ProteinReference
xref: uniprot Q09841 652
xref: PTHR11599:SF44
organism: Schizosaccharomyces pombe

Casein kinase I isoform gamma-2
type: ProteinReference
xref: PTHR11909:SF157
xref: uniprot P78368 1158
organism: Homo sapiens

uniprot P60901 649
type: UnificationXref
id: P60901
db: uniprot

DAT
type: RnaRegion
cellular location: intracellular
comment: SPECIES_TYPE=RNA

uniprot Q6P023 314
type: UnificationXref
id: Q6P023
db: uniprot

beta-Synuclein
type: Protein
entity reference: beta-Synuclein
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F7EI48 282
type: UnificationXref
id: F7EI48
db: uniprot

uniprot H2Q3P2 474
type: UnificationXref
id: H2Q3P2
db: uniprot

Synphilin
type: Protein
entity reference: Synphilin
feature: Synphilin s28 a49 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 1311
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 1312
left: alpha-Synuclein
interaction type: STATE_TRANSITION
right: alpha-Synuclein

uniprot P14681 289
type: UnificationXref
id: P14681
db: uniprot

uniprot O94579 612
type: UnificationXref
id: O94579
db: uniprot

uniprot B7PXP4 60
type: UnificationXref
id: B7PXP4
db: uniprot

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
type: ProteinReference
xref: uniprot P19404 949
xref: PTHR10371:SF3
organism: Homo sapiens

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot O02812 338
xref: PTHR24055:SF110
organism: Canis lupus familiaris

NADH-quinone oxidoreductase subunit E
type: ProteinReference
xref: uniprot P0AFD1 947
xref: PTHR10371:SF3
organism: Escherichia coli

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ub-_Parkin-RIGHT__Complex__Synphilin_Parkin_-_r43
controller: UbcH8

PTHR24068:SF170
type: RelationshipXref
id: PTHR24068:SF170
db: PANTHER Family
relationship type: By Homology

F-box/WD repeat-containing protein 7 isoform 1
type: ProteinReference
xref: uniprot A0A1D5Q962 1095
organism: Macaca mulatta

ncbitaxon 9258 78
type: UnificationXref
id: 9258
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r41 1323
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r41 1322
type: Stoichiometry
physical entity: Synphilin
stoichiometric coefficient: 1.0

Pael R s44 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pael-R
stoichiometric coefficient: 1.0

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot F1NEQ6 557
xref: PTHR11599:SF11
organism: Gallus gallus

uniprot C4M770 66
type: UnificationXref
id: C4M770
db: uniprot

uniprot A0A2J8PYX8 754
type: UnificationXref
id: A0A2J8PYX8
db: uniprot

ncbitaxon 190304 231
type: UnificationXref
id: 190304
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r41 1324
type: Stoichiometry
physical entity: Complex (Synphilin/Parkin)
stoichiometric coefficient: 1.0

Putative heat-shock protein hsp70
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot Q4Q7Y4 200
organism: Leishmania major

O C342
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s131 sa47 1284
cellular location: intracellular
comment: SPECIES_TYPE=ION

PARTICIPANT STOICHIOMETRY r47 1301
type: Stoichiometry
physical entity: p38 MAPK
stoichiometric coefficient: 1.0

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot P19419 848
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r47 1302
type: Stoichiometry
physical entity: p38 MAPK
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot Q9WTU6 446
organism: Mus musculus

Proteasome subunit alpha type-5
type: ProteinReference
xref: uniprot P32379 633
xref: PTHR11599:SF14
organism: Saccharomyces cerevisiae

EG:52C10.4 protein
type: ProteinReference
xref: uniprot Q7K738 478
organism: Drosophila melanogaster

uniprot H2PYG1 375
type: UnificationXref
id: H2PYG1
db: uniprot

Casein kinase I isoform gamma-2
type: ProteinReference
xref: uniprot H9EP27 1137
xref: PTHR11909:SF157
organism: Macaca mulatta

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot Q5ZLI2 682
xref: PTHR11599:SF10
organism: Gallus gallus

Proteasome subunit alpha type-6
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot Q2YDE4 663
organism: Bos taurus

uniprot Q6P3L3 213
type: UnificationXref
id: Q6P3L3
db: uniprot

uniprot H2R4R8 841
type: UnificationXref
id: H2R4R8
db: uniprot

uniprot F7CZ86 89
type: UnificationXref
id: F7CZ86
db: uniprot

uniprot Q84UI5 319
type: UnificationXref
id: Q84UI5
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot Q6P7Z3 689
organism: Xenopus tropicalis

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF144
xref: uniprot E1BD83 543
organism: Bos taurus

ncbitaxon 6239 96
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot Q3T0Y5 671
type: UnificationXref
id: Q3T0Y5
db: uniprot

Y125 alpha Synuclein s41 a58 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y125
feature location: Y125 alpha Synuclein s41 a58 rs2 Y125
comment: MODIFICATION_RESIDUE_NAME=Y125
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.69

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot Q84UI5 319
organism: Oryza sativa

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF13
xref: uniprot F6Z866 569
organism: Ornithorhynchus anatinus

uniprot F1PEK5 502
type: UnificationXref
id: F1PEK5
db: uniprot

a92_degraded
type: PhysicalEntity
cellular location: intracellular
comment: SPECIES_TYPE=DEGRADED

uniprot Q8W1K7 1183
type: UnificationXref
id: Q8W1K7
db: uniprot

Casein kinase 2, alpha prime polypeptide a
type: ProteinReference
xref: uniprot Q7ZU33 932
xref: PTHR24054:SF34
organism: Danio rerio

uniprot F6TY10 985
type: UnificationXref
id: F6TY10
db: uniprot

Chaperone protein DnaK
type: ProteinReference
xref: uniprot Q05558 182
xref: PTHR19375:SF184
organism: Streptomyces coelicolor

uniprot Q7Q707 931
type: UnificationXref
id: Q7Q707
db: uniprot

uniprot D3Z902 1098
type: UnificationXref
id: D3Z902
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot Q7ZW20 1071
organism: Danio rerio

uniprot Q91398 941
type: UnificationXref
id: Q91398
db: uniprot

Parkin s104 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

uniprot Q63844 313
type: UnificationXref
id: Q63844
db: uniprot

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot P06761 115
organism: Rattus norvegicus

Casein kinase II subunit alpha'
type: ProteinReference
xref: uniprot F1MJ55 887
xref: PTHR24054:SF34
organism: Bos taurus

ncbitaxon 214684 1054
type: UnificationXref
id: 214684
db: ncbitaxon

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Ub-_Complex__Parkin_Pael_R_-RIGHT__Complex__Parkin_Pael_R_-_r49
control type: INHIBITION
controller: Hsp70

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5QUZ8 266
xref: PTHR24055:SF203
organism: Macaca mulatta

alpha Synuclein s78 sa21 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot Q15019 518
type: UnificationXref
id: Q15019
db: uniprot

14-3-3 protein gamma
type: ProteinReference
xref: uniprot P61981 1024
xref: PTHR18860:SF22
organism: Homo sapiens

14-3-3 protein gamma
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot P61982 1025
organism: Mus musculus

14-3-3 protein gamma
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot P61983 1026
organism: Rattus norvegicus

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 159

uniprot Q6NYS3 1091
type: UnificationXref
id: Q6NYS3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot E9HGM4 1123
organism: Daphnia pulex

Tyrosine 3-monooxygenase
type: ProteinReference
xref: uniprot P17289 1111
xref: PTHR11473:SF18
organism: Bos taurus

Chaperone protein dnaK3
type: ProteinReference
xref: uniprot P73098 173
xref: PTHR19375:SF184
organism: Synechocystis

S129 alpha Synuclein s92 sa27 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S129
feature location: S129 alpha Synuclein s92 sa27 rs1 S129
comment: MODIFICATION_RESIDUE_NAME=S129
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

uniprot Q7ZUJ8 703
type: UnificationXref
id: Q7ZUJ8
db: uniprot

uniprot P42657 1019
type: UnificationXref
id: P42657
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EIC6 506
organism: Macaca mulatta

uniprot A0A0G2K8C5 463
type: UnificationXref
id: A0A0G2K8C5
db: uniprot

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 190

uniprot Q04062 255
type: UnificationXref
id: Q04062
db: uniprot

uniprot E2RPJ2 274
type: UnificationXref
id: E2RPJ2
db: uniprot

uniprot P29295 1143
type: UnificationXref
id: P29295
db: uniprot

PTHR19375:SF207
type: RelationshipXref
id: PTHR19375:SF207
db: PANTHER Family
relationship type: By Homology

uniprot Q99436 712
type: UnificationXref
id: Q99436
db: uniprot

uniprot Q9CWH6 713
type: UnificationXref
id: Q9CWH6
db: uniprot

Complex (Parkin/Pael-R)
type: Complex
component stoichiometry: Parkin s37 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pael R s38 sa14 STOICHIOMETRY ID COMPLEX
component: Pael-R
component: Parkin
feature: COMPLEX BINDING FEATURE s77 a106 1269
feature: COMPLEX BINDING FEATURE s77 a106 1271
cellular location: endoplasmic reticulum

uniprot Q383E5 189
type: UnificationXref
id: Q383E5
db: uniprot

Parkin
type: Protein
entity reference: Parkin
feature: COMPLEX PARTICIPANT BINDING FEATURE s122 sa41 1260
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PTHR19375:SF210
type: RelationshipXref
id: PTHR19375:SF210
db: PANTHER Family
relationship type: By Homology

uniprot F6YUQ2 1099
type: UnificationXref
id: F6YUQ2
db: uniprot

uniprot P53778 436
type: UnificationXref
id: P53778
db: uniprot

Torsin
type: ProteinReference
xref: PTHR10760:SF15
xref: uniprot A0A3Q1MQM0 449
organism: Bos taurus

uniprot A5PJU9 500
type: UnificationXref
id: A5PJU9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ub-_Parkin-RIGHT__Complex__Synphilin_Parkin_-_r43
controller: UbcH7

PTHR19375:SF215
type: RelationshipXref
id: PTHR19375:SF215
db: PANTHER Family
relationship type: By Homology

Cyclin E1
type: ProteinReference
xref: uniprot A9UMS1 347
xref: PTHR10177:SF71
organism: Xenopus tropicalis

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot Q6P0I2 688
xref: PTHR11599:SF144
organism: Danio rerio

uniprot Q91ZZ3 400
type: UnificationXref
id: Q91ZZ3
db: uniprot

uniprot Q6IQV0 930
type: UnificationXref
id: Q6IQV0
db: uniprot

uniprot O17586 596
type: UnificationXref
id: O17586
db: uniprot

uniprot P42168 1151
type: UnificationXref
id: P42168
db: uniprot

alpha Synuclein s78 sa21 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.528611247526151

Chaperone protein DnaK
type: ProteinReference
xref: uniprot P94317 177
xref: PTHR19375:SF184
organism: Bradyrhizobium diazoefficiens

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot Q0V9W8 1044
organism: Xenopus tropicalis

uniprot P10592 128
type: UnificationXref
id: P10592
db: uniprot

CASK s79 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CASK
stoichiometric coefficient: 1.0

uniprot P49722 646
type: UnificationXref
id: P49722
db: uniprot

CSNK1A1L isoform 1
type: ProteinReference
xref: uniprot H2REV2 1134
xref: PTHR11909:SF139
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot H2RF71 100
xref: PTHR19375:SF223
organism: Pan troglodytes

uniprot P68250 1035
type: UnificationXref
id: P68250
db: uniprot

Proteasome subunit alpha type-7
type: ProteinReference
xref: uniprot Q95005 709
xref: PTHR11599:SF15
organism: Caenorhabditis elegans

Proteasome subunit alpha type-5
type: ProteinReference
xref: PTHR11599:SF14
xref: uniprot Q95008 710
organism: Caenorhabditis elegans

Cytosolic heat shock protein 70, putative
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot A2FNS7 35
organism: Trichomonas vaginalis

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DPD5 840
xref: PTHR23122:SF40
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot F7DD51 91
organism: Monodelphis domestica

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot F6UT72 562
xref: PTHR11599:SF14
organism: Ornithorhynchus anatinus

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

uniprot F1PMN2 420
type: UnificationXref
id: F1PMN2
db: uniprot

uniprot P70498 15
type: UnificationXref
id: P70498
db: uniprot

uniprot P29311 1010
type: UnificationXref
id: P29311
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q16539 343
xref: PTHR24055:SF110
organism: Homo sapiens

uniprot A0A2R8QPB8 852
type: UnificationXref
id: A0A2R8QPB8
db: uniprot

uniprot Q9QZU9 480
type: UnificationXref
id: Q9QZU9
db: uniprot

uniprot Q8VYK9 1182
type: UnificationXref
id: Q8VYK9
db: uniprot

CHIP
type: Protein
entity reference: CHIP
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Complex (CDCrel-1/Parkin)
type: Complex
component stoichiometry: Parkin s122 sa41 STOICHIOMETRY ID COMPLEX
component stoichiometry: CDCrel 1 s118 sa40 STOICHIOMETRY ID COMPLEX
component: CDCrel-1
component: Parkin
feature: COMPLEX BINDING FEATURE s120 a174 1259
feature: COMPLEX BINDING FEATURE s120 a174 1257
cellular location: intracellular

Heat shock protein 70
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot Q8IB24 227
organism: Plasmodium falciparum

Extracellular signal-regulated kinase 1
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot Q5A1D3 310
organism: Candida albicans

uniprot P18420 616
type: UnificationXref
id: P18420
db: uniprot

uniprot Q8L4A7 705
type: UnificationXref
id: Q8L4A7
db: uniprot

uniprot O94281 902
type: UnificationXref
id: O94281
db: uniprot

Septin-2
type: ProteinReference
xref: uniprot Q15019 518
organism: Homo sapiens

Casein kinase II subunit beta
type: ProteinReference
xref: PTHR11740:SF5
xref: uniprot Q336R6 925
organism: Oryza sativa

uniprot K7CEN2 286
type: UnificationXref
id: K7CEN2
db: uniprot

Y125 alpha Synuclein s13 sa8 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y125
feature location: Y125 alpha Synuclein s13 sa8 rs2 Y125
comment: MODIFICATION_RESIDUE_NAME=Y125
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.69

uniprot Q75E44 217
type: UnificationXref
id: Q75E44
db: uniprot

uniprot F7G4T9 92
type: UnificationXref
id: F7G4T9
db: uniprot

uniprot P11484 134
type: UnificationXref
id: P11484
db: uniprot

uniprot Q3ZBT5 385
type: UnificationXref
id: Q3ZBT5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LPV4 836
xref: PTHR23122:SF40
organism: Bos taurus

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 277

uniprot F7GQM5 507
type: UnificationXref
id: F7GQM5
db: uniprot

STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__Complex__N_Y125_alpha_Synuclein_-_r53
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 1387
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 1386
left: alpha-Synuclein
interaction type: STATE_TRANSITION
right: Complex (N Y125/alpha-Synuclein)

Gamma-synuclein
type: ProteinReference
xref: uniprot Q9Z0F7 834
organism: Mus musculus

uniprot P0DKK3 613
type: UnificationXref
id: P0DKK3
db: uniprot

alpha Synuclein s95 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

uniprot K7AWV1 786
type: UnificationXref
id: K7AWV1
db: uniprot

S129 alpha Synuclein s4 sa6 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S129
feature location: S129 alpha Synuclein s4 sa6 rs1 S129
comment: MODIFICATION_RESIDUE_NAME=S129
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

Proteasome subunit beta type-3
type: ProteinReference
xref: PTHR11599:SF62
xref: uniprot P25451 627
organism: Saccharomyces cerevisiae

ncbitaxon 7668 824
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot F7HT93 856
type: UnificationXref
id: F7HT93
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF373
xref: uniprot Q8WQM5 823
organism: Strongylocentrotus purpuratus

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r1
controller: ROS

Torsin-2A
type: ProteinReference
xref: uniprot Q5JU69 457
xref: PTHR10760:SF4
organism: Homo sapiens

Septin-1
type: ProteinReference
xref: uniprot Q8WYJ6 522
organism: Homo sapiens

uniprot A0A3Q1LJZ7 413
type: UnificationXref
id: A0A3Q1LJZ7
db: uniprot

14-3-3 protein theta
type: ProteinReference
xref: PTHR18860:SF3
xref: uniprot P27348 1008
organism: Homo sapiens

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF90
xref: uniprot A0A2I3TMT4 753
organism: Pan troglodytes

uniprot A9T4Y7 875
type: UnificationXref
id: A9T4Y7
db: uniprot

uniprot F7H5X2 396
type: UnificationXref
id: F7H5X2
db: uniprot

Chaperone protein DnaK
type: ProteinReference
xref: uniprot P0A6Y8 119
xref: PTHR19375:SF184
organism: Escherichia coli

14-3-3 protein sigma
type: ProteinReference
xref: uniprot O70456 1007
xref: PTHR18860:SF14
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR11932:SF81
xref: uniprot F1MYD0 1080
organism: Bos taurus

uniprot Q61696 211
type: UnificationXref
id: Q61696
db: uniprot

Sodium-dependent dopamine transporter
type: ProteinReference
xref: PTHR11616:SF38
xref: uniprot Q01959 738
organism: Homo sapiens

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot F6YDY3 568
organism: Xenopus tropicalis

uniprot Q9M1Z5 330
type: UnificationXref
id: Q9M1Z5
db: uniprot

uniprot A7UVK8 38
type: UnificationXref
id: A7UVK8
db: uniprot

Mediator of RNA polymerase II transcription subunit 37a
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot Q9LKR3 247
organism: Arabidopsis thaliana

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__TH_Parkin_-_Ub-RIGHT__Complex__TH_Parkin_-_r59
controller: UbcH7

uniprot P19139 907
type: UnificationXref
id: P19139
db: uniprot

intracellular
type: CellularLocationVocabulary
xref: GO GO:0005622 4

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P28482 294
xref: PTHR24055:SF203
organism: Homo sapiens

uniprot Q95008 710
type: UnificationXref
id: Q95008
db: uniprot

uniprot Q6C8U8 929
type: UnificationXref
id: Q6C8U8
db: uniprot

uniprot Q0V8L6 19
type: UnificationXref
id: Q0V8L6
db: uniprot

uniprot A4GTP4 847
type: UnificationXref
id: A4GTP4
db: uniprot

Cyclin E s84 a113 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Proteasome subunit beta
type: ProteinReference
xref: uniprot F7F3A6 575
xref: PTHR11599:SF59
organism: Monodelphis domestica

O-glyc
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s94 sa29 1230
cellular location: intracellular
comment: SPECIES_TYPE=ION

14-3-3 protein epsilon
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot P92177 1040
organism: Drosophila melanogaster

Septin 5
type: ProteinReference
xref: PTHR18884:SF68
xref: uniprot F1PCZ0 501
organism: Canis lupus familiaris

uniprot P08181 904
type: UnificationXref
id: P08181
db: uniprot

Syntaxin-7
type: ProteinReference
xref: uniprot O70439 382
xref: PTHR19957:SF90
organism: Mus musculus

Ubiquitin/ISG15-conjugating enzyme E2 L6
type: ProteinReference
xref: PTHR24068:SF43
xref: uniprot Q9QZU9 480
organism: Mus musculus

uniprot Q5ZMD1 1061
type: UnificationXref
id: Q5ZMD1
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P27361 292
organism: Homo sapiens

Proteasome subunit alpha type-3
type: ProteinReference
xref: uniprot O70435 606
xref: PTHR11599:SF10
organism: Mus musculus

uniprot F6Q7B1 350
type: UnificationXref
id: F6Q7B1
db: uniprot

AGR107Cp
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot Q74ZU1 1067
organism: Ashbya gossypii

PTHR11909:SF409
type: RelationshipXref
id: PTHR11909:SF409
db: PANTHER Family
relationship type: By Homology

14-3-3 protein
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot C0H4V6 971
organism: Plasmodium falciparum

PTHR11909:SF406
type: RelationshipXref
id: PTHR11909:SF406
db: PANTHER Family
relationship type: By Homology

uniprot Q16539 343
type: UnificationXref
id: Q16539
db: uniprot

uniprot P0DMW1 126
type: UnificationXref
id: P0DMW1
db: uniprot

AT15039p
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot Q7JWT4 1171
organism: Drosophila melanogaster

uniprot Q9SQR8 1197
type: UnificationXref
id: Q9SQR8
db: uniprot

Synphilin s30 sa9 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot Q9HRY2 241
type: UnificationXref
id: Q9HRY2
db: uniprot

uniprot Q8TAA3 707
type: UnificationXref
id: Q8TAA3
db: uniprot

uniprot O94517 611
type: UnificationXref
id: O94517
db: uniprot

uniprot A7SG27 871
type: UnificationXref
id: A7SG27
db: uniprot

uniprot Q7RVK6 1069
type: UnificationXref
id: Q7RVK6
db: uniprot

uniprot Q5PRD0 1055
type: UnificationXref
id: Q5PRD0
db: uniprot

uniprot A0A3Q1MQM0 449
type: UnificationXref
id: A0A3Q1MQM0
db: uniprot

ncbitaxon 559292 117
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot F6QQC0 768
type: UnificationXref
id: F6QQC0
db: uniprot

uniprot P07948 794
type: UnificationXref
id: P07948
db: uniprot

Proteasome subunit beta
type: ProteinReference
xref: PTHR11599:SF42
xref: uniprot E2RPC6 549
organism: Canis lupus familiaris

uniprot Q53RJ5 204
type: UnificationXref
id: Q53RJ5
db: uniprot

ERK
type: ProteinReference
xref: P01211
standard name: Extracellular signal-regulated kinase
comment: ENTITY_REFERENCE_NOTES= Long Name: ERK Synonym: MAPK Accession: P01211
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.ERK
member entity reference: Mitogen-activated protein kinase mpk-1
member entity reference: Extracellular signal-regulated kinase 2
member entity reference: Mitogen-activated protein kinase 15
member entity reference: Mitogen-activated protein kinase KSS1
member entity reference: Mitogen-activated protein kinase 7
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Mitogen-activated protein kinase 6
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Extracellular signal-regulated kinase 1
member entity reference: Mitogen-activated protein kinase 4
member entity reference: Mitogen-activated protein kinase 2
member entity reference: Mitogen-activated protein kinase 19
member entity reference: Mitogen-activated protein kinase FUS3
member entity reference: Mitogen-activated protein kinase 5
member entity reference: Mitogen-activated protein kinase 18
member entity reference: Mitogen-activated protein kinase 10
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Mitogen-activated protein kinase 16
member entity reference: Mitogen-activated protein kinase spk1
member entity reference: Mitogen-activated protein kinase (Fragment)
member entity reference: Mitogen-activated protein kinase 20
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase 13

Casein kinase II subunit alpha
type: ProteinReference
xref: PTHR24054:SF34
xref: uniprot H9ENR6 894
organism: Macaca mulatta

uniprot F1MBI1 555
type: UnificationXref
id: F1MBI1
db: uniprot

uniprot F6XLR8 988
type: UnificationXref
id: F6XLR8
db: uniprot

uniprot C4LXB1 972
type: UnificationXref
id: C4LXB1
db: uniprot

uniprot Q9Y7T8 733
type: UnificationXref
id: Q9Y7T8
db: uniprot

uniprot Q7DLR9 691
type: UnificationXref
id: Q7DLR9
db: uniprot

uniprot Q68G38 458
type: UnificationXref
id: Q68G38
db: uniprot

PTHR11685:SF212
type: RelationshipXref
id: PTHR11685:SF212
db: PANTHER Family
relationship type: By Homology

20S proteasome
type: Protein
entity reference: 20S proteasome
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot P16474 136
type: UnificationXref
id: P16474
db: uniprot

Y125 alpha Synuclein s39 a56 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y125
feature location: Y125 alpha Synuclein s39 a56 rs2 Y125
comment: MODIFICATION_RESIDUE_NAME=Y125
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.69

Stress-activated protein kinase jnk-1
type: ProteinReference
xref: PTHR24055:SF341
xref: uniprot Q8WQG9 442
organism: Caenorhabditis elegans

Mitogen-activated protein kinase 4
type: ProteinReference
xref: PTHR24055:SF196
xref: uniprot Q5Z859 312
organism: Oryza sativa

uniprot F6YAB9 337
type: UnificationXref
id: F6YAB9
db: uniprot

uniprot C4M0F4 973
type: UnificationXref
id: C4M0F4
db: uniprot

PLD2
type: ProteinReference
xref: P01207
standard name: Phospholipase D2
comment: ENTITY_REFERENCE_NOTES= Long Name: Phospholipase D2 Synonym: Synonym not specified Accession: P01207
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.PLD2
member entity reference: Phospholipase D2
member entity reference: Phospholipase

uniprot E2QVP6 975
type: UnificationXref
id: E2QVP6
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot A0A1D5RAS1 529
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Parkin_Pael_R_-RIGHT__a109_degraded-_r50
controller: Complex (19S proteasome/20S proteasome)

STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__Complex__O_glyc_alpha_Synuclein_-_r55
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 1376
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 1375
left: alpha-Synuclein
interaction type: STATE_TRANSITION
right: Complex (O-glyc/alpha-Synuclein)

uniprot Q95PZ9 1186
type: UnificationXref
id: Q95PZ9
db: uniprot

uniprot Q9Z2A6 333
type: UnificationXref
id: Q9Z2A6
db: uniprot

Heat shock protein SSA3
type: ProteinReference
xref: PTHR19375:SF385
xref: uniprot P09435 116
organism: Saccharomyces cerevisiae

uniprot P21708 291
type: UnificationXref
id: P21708
db: uniprot

uniprot A0A2I3RLP7 1115
type: UnificationXref
id: A0A2I3RLP7
db: uniprot

uniprot P37840 404
type: UnificationXref
id: P37840
db: uniprot

uniprot Q3ZCH0 194
type: UnificationXref
id: Q3ZCH0
db: uniprot

Casein kinase I isoform alpha
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot P97633 1159
organism: Rattus norvegicus

AGAP004581-PA
type: ProteinReference
xref: uniprot A7UT42 36
xref: PTHR19375:SF371
organism: Anopheles gambiae

uniprot P29843 154
type: UnificationXref
id: P29843
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF90
xref: uniprot Q640S9 819
organism: Xenopus tropicalis

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q63844 313
organism: Mus musculus

uniprot D6XEX9 542
type: UnificationXref
id: D6XEX9
db: uniprot

uniprot O54833 897
type: UnificationXref
id: O54833
db: uniprot

STATE_TRANSITION_LEFT__PLD2-RIGHT__PLD2-_r12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 1313
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 1314
left: PLD2
interaction type: STATE_TRANSITION
right: PLD2

Parkin
type: Protein
entity reference: Parkin
feature: COMPLEX PARTICIPANT BINDING FEATURE s98 sa33 1242
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR24068:SF67
xref: uniprot F6ZC17 485
organism: Macaca mulatta

uniprot F7GRP2 781
type: UnificationXref
id: F7GRP2
db: uniprot

uniprot G2HIX7 579
type: UnificationXref
id: G2HIX7
db: uniprot

Casein kinase II, alpha chain, putative, expressed
type: ProteinReference
xref: uniprot Q8W5G9 940
xref: PTHR24054:SF43
organism: Oryza sativa

uniprot F7FHD1 283
type: UnificationXref
id: F7FHD1
db: uniprot

Mitogen-activated protein kinase FUS3
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot P16892 290
organism: Saccharomyces cerevisiae

uniprot F1PXS7 275
type: UnificationXref
id: F1PXS7
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r46
controller: alpha-Synuclein

uniprot O59855 107
type: UnificationXref
id: O59855
db: uniprot

uniprot O23708 597
type: UnificationXref
id: O23708
db: uniprot

alpha Synuclein s41 a58 rs4
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.528611247526151

PTHR19375:SF371
type: RelationshipXref
id: PTHR19375:SF371
db: PANTHER Family
relationship type: By Homology

PTHR19375:SF379
type: RelationshipXref
id: PTHR19375:SF379
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot Q7Q5D3 822
xref: PTHR24418:SF194
organism: Anopheles gambiae

70 kDa heat shock protein
type: ProteinReference
xref: PTHR19375:SF418
xref: uniprot Q10NA9 186
organism: Oryza sativa

Heat shock protein SSC3, mitochondrial
type: ProteinReference
xref: uniprot P39987 163
xref: PTHR19375:SF184
organism: Saccharomyces cerevisiae

uniprot Q7QDD7 479
type: UnificationXref
id: Q7QDD7
db: uniprot

ncbitaxon 3055 43
type: UnificationXref
id: 3055
db: ncbitaxon

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2RA86 285
xref: PTHR24055:SF393
organism: Pan troglodytes

Casein kinase II subunit beta
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot F6T6M8 890
organism: Monodelphis domestica

alpha Synuclein s41 a58 rs3
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

PTHR19375:SF380
type: RelationshipXref
id: PTHR19375:SF380
db: PANTHER Family
relationship type: By Homology

ncbitaxon 13616 83
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot Q8TG11 937
type: UnificationXref
id: Q8TG11
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot Q6GQM3 685
xref: PTHR11599:SF113
organism: Danio rerio

uniprot F6Y4G8 423
type: UnificationXref
id: F6Y4G8
db: uniprot

Casein kinase I isoform gamma-3
type: ProteinReference
xref: uniprot Q62763 1167
xref: PTHR11909:SF151
organism: Rattus norvegicus

DISSOCIATION
type: RelationshipTypeVocabulary

uniprot A8X8Y1 1120
type: UnificationXref
id: A8X8Y1
db: uniprot

Heat shock cognate 70-kd protein,-like
type: ProteinReference
xref: PTHR19375:SF448
xref: uniprot B0S610 58
organism: Danio rerio

uniprot F6TKL3 421
type: UnificationXref
id: F6TKL3
db: uniprot

uniprot P11141 130
type: UnificationXref
id: P11141
db: uniprot

Casein kinase I isoform gamma-1
type: ProteinReference
xref: uniprot Q62761 1165
xref: PTHR11909:SF156
organism: Rattus norvegicus

Casein kinase I isoform gamma-2
type: ProteinReference
xref: PTHR11909:SF157
xref: uniprot Q62762 1166
organism: Rattus norvegicus

uniprot H9ENA3 1136
type: UnificationXref
id: H9ENA3
db: uniprot

Casein kinase I homolog 3
type: ProteinReference
xref: PTHR11909:SF374
xref: uniprot P39962 1146
organism: Saccharomyces cerevisiae

uniprot F1QK71 73
type: UnificationXref
id: F1QK71
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F7GRP2 781
xref: PTHR24418:SF407
organism: Macaca mulatta

Multifunctional chaperone, putative
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot B7Q5I4 970
organism: Ixodes scapularis

uniprot F7ATP9 370
type: UnificationXref
id: F7ATP9
db: uniprot

CDCrel-1
type: Protein
entity reference: CDCrel-1
feature: CDCrel 1 s117 a168 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

CDCrel 1 s118 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CDCrel-1
stoichiometric coefficient: 1.0

Bradyrhizobium diazoefficiens
type: BioSource
xref: ncbitaxon 224911 178

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H415 1133
xref: PTHR11909:SF151
organism: Macaca mulatta

Y125 alpha Synuclein s1 a1 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y125
feature location: Y125 alpha Synuclein s1 a1 rs2 Y125
comment: MODIFICATION_RESIDUE_NAME=Y125
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.69

uniprot Q9VEJ4 472
type: UnificationXref
id: Q9VEJ4
db: uniprot

19S proteasome
type: ProteinReference
xref: P01209
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.19S proteasome
comment: ENTITY_REFERENCE_NOTES= Long Name: 19S proteasome Synonym: Synonym not specified Accession: P01209
member entity reference: Probable 26S proteasome regulatory subunit rpn9
member entity reference: 26S proteasome regulatory subunit RPN9

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A4FV00 416
organism: Bos taurus

uniprot Q9LSU1 717
type: UnificationXref
id: Q9LSU1
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot F7CYE3 427
organism: Xenopus tropicalis

GO GO:0005739 3
type: UnificationXref
id: GO:0005739
db: GO

uniprot Q09841 652
type: UnificationXref
id: Q09841
db: uniprot

PARTICIPANT STOICHIOMETRY r46 1305
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r46 1306
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

G1/S-specific cyclin-E1
type: ProteinReference
xref: uniprot P39949 355
xref: PTHR10177:SF71
organism: Rattus norvegicus

uniprot Q27975 188
type: UnificationXref
id: Q27975
db: uniprot

19S proteasome s22 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 19S proteasome
stoichiometric coefficient: 1.0

Proteasome subunit beta
type: ProteinReference
xref: uniprot F6WNU0 563
xref: PTHR11599:SF42
organism: Monodelphis domestica

eco ECO:0000303 340
type: UnificationXref
id: ECO:0000303
db: eco

PTHR12874:SF9
type: RelationshipXref
id: PTHR12874:SF9
db: PANTHER Family
relationship type: By Homology

TH isoform 6
type: ProteinReference
xref: uniprot H2Q2W7 1108
xref: PTHR11473:SF18
organism: Pan troglodytes

uniprot P63104 1034
type: UnificationXref
id: P63104
db: uniprot

uniprot P36604 160
type: UnificationXref
id: P36604
db: uniprot

alpha Synuclein s29 sa4 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.528611247526151

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF356
xref: uniprot E2RPJ2 274
organism: Canis lupus familiaris

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot F0ZYX2 554
xref: PTHR11599:SF13
organism: Dictyostelium purpureum

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot F6ZTS0 425
organism: Macaca mulatta

uniprot F6TA21 983
type: UnificationXref
id: F6TA21
db: uniprot

uniprot F7BV42 774
type: UnificationXref
id: F7BV42
db: uniprot

PTHR22882:SF3
type: RelationshipXref
id: PTHR22882:SF3
db: PANTHER Family
relationship type: By Homology

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot H2Q378 581
xref: PTHR11599:SF12
organism: Pan troglodytes

PTHR19375:SF388
type: RelationshipXref
id: PTHR19375:SF388
db: PANTHER Family
relationship type: By Homology

PTHR19375:SF385
type: RelationshipXref
id: PTHR19375:SF385
db: PANTHER Family
relationship type: By Homology

Probable NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
type: ProteinReference
xref: uniprot Q20719 953
xref: PTHR10371:SF3
organism: Caenorhabditis elegans

PTHR19375:SF382
type: RelationshipXref
id: PTHR19375:SF382
db: PANTHER Family
relationship type: By Homology

PTHR19375:SF391
type: RelationshipXref
id: PTHR19375:SF391
db: PANTHER Family
relationship type: By Homology

ncbitaxon 7227 114
type: UnificationXref
id: 7227
db: ncbitaxon

alpha Synuclein s29 sa4 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot Q8W5G9 940
type: UnificationXref
id: Q8W5G9
db: uniprot

uniprot P42208 514
type: UnificationXref
id: P42208
db: uniprot

Synuclein, alpha interacting protein (Synphilin) (Predicted), isoform CRA_a
type: ProteinReference
xref: PTHR22882:SF3
xref: uniprot D3ZWQ5 492
organism: Rattus norvegicus

uniprot E2RHZ1 881
type: UnificationXref
id: E2RHZ1
db: uniprot

uniprot P70618 342
type: UnificationXref
id: P70618
db: uniprot

uniprot Q8NEV1 935
type: UnificationXref
id: Q8NEV1
db: uniprot

PTHR19375:SF397
type: RelationshipXref
id: PTHR19375:SF397
db: PANTHER Family
relationship type: By Homology

E3 ubiquitin-protein ligase CHIP
type: ProteinReference
xref: PTHR46803:SF2
xref: uniprot Q9UNE7 364
organism: Homo sapiens

DAT
type: Protein
entity reference: DAT
feature: COMPLEX PARTICIPANT BINDING FEATURE s130 sa46 1282
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PTHR19375:SF395
type: RelationshipXref
id: PTHR19375:SF395
db: PANTHER Family
relationship type: By Homology

uniprot Q63754 399
type: UnificationXref
id: Q63754
db: uniprot

uniprot Q9R1P4 722
type: UnificationXref
id: Q9R1P4
db: uniprot

uniprot F7ETB2 574
type: UnificationXref
id: F7ETB2
db: uniprot

Parkin
type: Protein
entity reference: Parkin
feature: COMPLEX PARTICIPANT BINDING FEATURE s46 sa18 1250
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

CDCrel-1
type: Protein
entity reference: CDCrel-1
feature: CDCrel 1 s128 sa44 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s128 sa44 1286
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot Q9V5C6 725
type: UnificationXref
id: Q9V5C6
db: uniprot

uniprot F7H5G4 259
type: UnificationXref
id: F7H5G4
db: uniprot

uniprot P34064 635
type: UnificationXref
id: P34064
db: uniprot

uniprot Q0KHR7 516
type: UnificationXref
id: Q0KHR7
db: uniprot

Tau TuBulin Kinase
type: ProteinReference
xref: PTHR11909:SF297
xref: uniprot Q22033 1161
organism: Caenorhabditis elegans

uniprot O81147 607
type: UnificationXref
id: O81147
db: uniprot

uniprot A8XX71 1121
type: UnificationXref
id: A8XX71
db: uniprot

uniprot Q9NHE1 1195
type: UnificationXref
id: Q9NHE1
db: uniprot

Casein kinase II subunit alpha 3
type: ProteinReference
xref: PTHR24054:SF16
xref: uniprot Q8NEV1 935
organism: Homo sapiens

Ubiquitin carboxyl-terminal hydrolase isozyme L1
type: ProteinReference
xref: PTHR10589:SF19
xref: uniprot Q00981 261
organism: Rattus norvegicus

uniprot O42265 602
type: UnificationXref
id: O42265
db: uniprot

uniprot H2R9R9 352
type: UnificationXref
id: H2R9R9
db: uniprot

uniprot P48729 1152
type: UnificationXref
id: P48729
db: uniprot

Heat shock protein family A (Hsp70) member 8
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot F6QKL0 75
organism: Xenopus tropicalis

Predicted protein
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot A7RPJ6 1119
organism: Nematostella vectensis

uniprot Q8H386 934
type: UnificationXref
id: Q8H386
db: uniprot

14-3-3 zeta
type: ProteinReference
xref: uniprot E9H1W5 978
xref: PTHR18860:SF106
organism: Daphnia pulex

PARTICIPANT STOICHIOMETRY r22 1380
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

alpha-Synuclein
type: Protein
entity reference: alpha-Synuclein
feature: COMPLEX PARTICIPANT BINDING FEATURE s78 sa21 1210
feature: S129 alpha Synuclein s78 sa21 rs1
feature: alpha Synuclein s78 sa21 rs4
feature: Y125 alpha Synuclein s78 sa21 rs2
feature: alpha Synuclein s78 sa21 rs3
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Ubiquitin carboxyl-terminal hydrolase
type: ProteinReference
xref: uniprot A0A2I3TWC0 258
xref: PTHR10589:SF19
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r22 1381
type: Stoichiometry
physical entity: 19S proteasome
stoichiometric coefficient: 1.0

uniprot Q5XF24 1163
type: UnificationXref
id: Q5XF24
db: uniprot

PARTICIPANT STOICHIOMETRY r22 1382
type: Stoichiometry
physical entity: Complex (19S proteasome/alpha-Synuclein)
stoichiometric coefficient: 1.0

uniprot A9RCV9 52
type: UnificationXref
id: A9RCV9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RLH5 76
xref: PTHR19375:SF379
organism: Macaca mulatta

Alpha-synuclein
type: ProteinReference
xref: uniprot O55042 402
xref: PTHR13820:SF5
organism: Mus musculus

uniprot P08103 795
type: UnificationXref
id: P08103
db: uniprot

uniprot P40306 643
type: UnificationXref
id: P40306
db: uniprot

uniprot Q3ZCM0 816
type: UnificationXref
id: Q3ZCM0
db: uniprot

Tyrosine-protein kinase (Fragment)
type: ProteinReference
xref: PTHR24418:SF245
xref: uniprot A0A2J8PYX8 754
organism: Pan troglodytes

Pael-R
type: Protein
entity reference: Pael-R
feature: Pael R s75 a101 rs1
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 16
type: ProteinReference
xref: uniprot Q8W4J2 321
organism: Arabidopsis thaliana

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 65

uniprot F6UGQ3 839
type: UnificationXref
id: F6UGQ3
db: uniprot

uniprot P40915 950
type: UnificationXref
id: P40915
db: uniprot

uniprot L7N050 105
type: UnificationXref
id: L7N050
db: uniprot

uniprot Q6H852 687
type: UnificationXref
id: Q6H852
db: uniprot

uniprot Q4Q744 197
type: UnificationXref
id: Q4Q744
db: uniprot

uniprot F7E0A0 371
type: UnificationXref
id: F7E0A0
db: uniprot

uniprot O14939 12
type: UnificationXref
id: O14939
db: uniprot

uniprot P08631 796
type: UnificationXref
id: P08631
db: uniprot

uniprot F7DPD5 840
type: UnificationXref
id: F7DPD5
db: uniprot

HL05730p
type: ProteinReference
xref: uniprot Q9VEJ4 472
xref: PTHR24068:SF135
organism: Drosophila melanogaster

Proteasome subunit alpha-type 8
type: ProteinReference
xref: uniprot Q8TAA3 707
xref: PTHR11599:SF144
organism: Homo sapiens

uniprot Q61327 739
type: UnificationXref
id: Q61327
db: uniprot

uniprot A0A3Q2TY19 415
type: UnificationXref
id: A0A3Q2TY19
db: uniprot

uniprot Q9LW62 1194
type: UnificationXref
id: Q9LW62
db: uniprot

uniprot A0A2I3SMC0 1096
type: UnificationXref
id: A0A2I3SMC0
db: uniprot

uniprot Q3UYH7 866
type: UnificationXref
id: Q3UYH7
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6ZKB3 424
xref: PTHR24055:SF222
organism: Macaca mulatta

uniprot P07101 1110
type: UnificationXref
id: P07101
db: uniprot

Putative casein kinase II subunit beta-4
type: ProteinReference
xref: uniprot O80507 900
xref: PTHR11740:SF30
organism: Arabidopsis thaliana

14-3-3 protein zeta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot Q5ZKC9 1058
organism: Gallus gallus

uniprot Q6GQM3 685
type: UnificationXref
id: Q6GQM3
db: uniprot

Casein kinase I isoform alpha isoform 1
type: ProteinReference
xref: uniprot H9ENA3 1136
xref: PTHR11909:SF84
organism: Macaca mulatta

14-3-3
type: Protein
entity reference: 14-3-3
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q58DU5 679
type: UnificationXref
id: Q58DU5
db: uniprot

uniprot Q7ZV77 704
type: UnificationXref
id: Q7ZV77
db: uniprot

uniprot A0A2R8QI56 482
type: UnificationXref
id: A0A2R8QI56
db: uniprot

uniprot Q7T2E3 1172
type: UnificationXref
id: Q7T2E3
db: uniprot

Fatty acids
type: SmallMolecule
cellular location: intracellular
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6WBW6 279
xref: PTHR24055:SF356
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F6WV79 422
organism: Monodelphis domestica

uniprot Q8LPI7 1178
type: UnificationXref
id: Q8LPI7
db: uniprot

alpha Synuclein s92 sa27 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Proteasome subunit alpha type-4
type: ProteinReference
xref: PTHR11599:SF13
xref: uniprot P18053 615
organism: Drosophila melanogaster

Casein kinase II subunit alpha-4, chloroplastic
type: ProteinReference
xref: uniprot O64816 898
xref: PTHR24054:SF43
organism: Arabidopsis thaliana

Casein kinase II subunit alpha-3
type: ProteinReference
xref: PTHR24054:SF47
xref: uniprot O64817 899
organism: Arabidopsis thaliana

Cytoplasmic heat shock protein 70
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot A2EQB9 33
organism: Trichomonas vaginalis

uniprot A0A1D5RAS1 529
type: UnificationXref
id: A0A1D5RAS1
db: uniprot

Proteasome subunit beta
type: ProteinReference
xref: uniprot F7GNS6 577
xref: PTHR11599:SF59
organism: Macaca mulatta

uniprot P39745 295
type: UnificationXref
id: P39745
db: uniprot

Proteasome subunit beta
type: ProteinReference
xref: PTHR11599:SF42
xref: uniprot F1MBI1 555
organism: Bos taurus

Proteasome subunit beta
type: ProteinReference
xref: PTHR11599:SF42
xref: uniprot F1Q5N4 558
organism: Danio rerio

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P47811 341
xref: PTHR24055:SF110
organism: Mus musculus

alpha Synuclein s92 sa27 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.528611247526151

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 110

UbcH8
type: ProteinReference
xref: P01223
standard name: ubiquitin-conjugating enzyme E2E2
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.UbcH8
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: ubiquitin-conjugating enzyme E2E2 Synonym: Synonym not specified Accession: P01223
member entity reference: UBiquitin Conjugating enzyme
member entity reference: AGAP001056-PA
member entity reference: Ubiquitin-conjugating enzyme E2-18 kDa
member entity reference: Ubiquitin/ISG15-conjugating enzyme E2 L6
member entity reference: EG:52C10.4 protein
member entity reference: UBE2L6 isoform 2
member entity reference: Protein CBR-UBC-18

PTHR18896:SF121
type: RelationshipXref
id: PTHR18896:SF121
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P21708 291
xref: PTHR24055:SF393
organism: Rattus norvegicus

Heat shock cognate 70 kDa protein 2, putative, expressed
type: ProteinReference
xref: uniprot Q84TA1 222
xref: PTHR19375:SF417
organism: Oryza sativa

Proteasome subunit alpha-type 7-like
type: ProteinReference
xref: PTHR11599:SF144
xref: uniprot Q9CWH6 713
organism: Mus musculus

Protein serine/threonine kinase
type: ProteinReference
xref: uniprot F0Z8A7 886
xref: PTHR24054:SF0
organism: Dictyostelium purpureum

Trichomonas vaginalis
type: BioSource
xref: ncbitaxon 5722 26

Synphilin
type: Protein
entity reference: Synphilin
feature: Synphilin s34 sa11 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa11 1220
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q07014 813
type: UnificationXref
id: Q07014
db: uniprot

uniprot Q9LSX4 1193
type: UnificationXref
id: Q9LSX4
db: uniprot

uniprot Q8INI8 229
type: UnificationXref
id: Q8INI8
db: uniprot

uniprot F7FRT9 997
type: UnificationXref
id: F7FRT9
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 59

Uncharacterized protein
type: ProteinReference
xref: uniprot F6V652 82
xref: PTHR19375:SF382
organism: Monodelphis domestica

Casein kinase 2 alpha 2
type: ProteinReference
xref: PTHR24054:SF34
xref: uniprot F6R511 888
organism: Monodelphis domestica

PTHR24055:SF438
type: RelationshipXref
id: PTHR24055:SF438
db: PANTHER Family
relationship type: By Homology

PTHR24055:SF439
type: RelationshipXref
id: PTHR24055:SF439
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF88
xref: uniprot F7E1T5 373
organism: Macaca mulatta

gamma-Synuclein
type: ProteinReference
xref: P01231
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: gamma-Synuclein Synonym: Synonym not specified Accession: P01231
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC._gamma_-Synuclein
member entity reference: Gamma-synuclein
member entity reference: Uncharacterized protein

uniprot Q4Q970 202
type: UnificationXref
id: Q4Q970
db: uniprot

uniprot F6RN85 889
type: UnificationXref
id: F6RN85
db: uniprot

uniprot H2QRK8 98
type: UnificationXref
id: H2QRK8
db: uniprot

uniprot Q95NE7 344
type: UnificationXref
id: Q95NE7
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot A0A2I3SKP4 752
organism: Pan troglodytes

Cul1 protein
type: ProteinReference
xref: PTHR11932:SF81
xref: uniprot B1WBY1 1076
organism: Rattus norvegicus

Heat shock 70 kDa protein A
type: ProteinReference
xref: uniprot P09446 118
xref: PTHR19375:SF457
organism: Caenorhabditis elegans

Tyrosine-protein kinase HCK
type: ProteinReference
xref: PTHR24418:SF245
xref: uniprot P50545 808
organism: Rattus norvegicus

uniprot P06240 791
type: UnificationXref
id: P06240
db: uniprot

DA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF90
xref: uniprot A0A1D5RAI3 750
organism: Macaca mulatta

20S proteasome s23 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 20S proteasome
stoichiometric coefficient: 1.0

uniprot O23236 287
type: UnificationXref
id: O23236
db: uniprot

uniprot Q99PS2 1187
type: UnificationXref
id: Q99PS2
db: uniprot

uniprot P31947 1012
type: UnificationXref
id: P31947
db: uniprot

Casein kinase II subunit beta
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot F6WVD0 892
organism: Xenopus tropicalis

14-3-3-like protein GF14-C
type: ProteinReference
xref: uniprot Q6ZKC0 1066
xref: PTHR18860:SF109
organism: Oryza sativa

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot Q5BBL8 208
organism: Emericella nidulans

PARTICIPANT STOICHIOMETRY r7 1290
type: Stoichiometry
physical entity: Complex I
stoichiometric coefficient: 1.0

uniprot A0A2I3SIH9 751
type: UnificationXref
id: A0A2I3SIH9
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot F1NC02 556
xref: PTHR11599:SF13
organism: Gallus gallus

uniprot F6TEF3 740
type: UnificationXref
id: F6TEF3
db: uniprot

Mitogen-activated protein kinase 5
type: ProteinReference
xref: uniprot Q10N20 298
organism: Oryza sativa

alpha-Synuclein
type: Protein
entity reference: alpha-Synuclein
feature: S129 alpha Synuclein s92 sa27 rs1
feature: alpha Synuclein s92 sa27 rs4
feature: Y125 alpha Synuclein s92 sa27 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s92 sa27 1226
feature: alpha Synuclein s92 sa27 rs3
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

14-3-3 protein beta/alpha
type: ProteinReference
xref: PTHR18860:SF28
xref: uniprot P35213 1014
organism: Rattus norvegicus

Parkin s85 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 1289
type: Stoichiometry
physical entity: Complex I
stoichiometric coefficient: 1.0

uniprot C3ZBE3 879
type: UnificationXref
id: C3ZBE3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FRT9 997
xref: PTHR18860:SF7
organism: Monodelphis domestica

uniprot F7GNS6 577
type: UnificationXref
id: F7GNS6
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF245
xref: uniprot A0A3Q1MYA3 755
organism: Bos taurus

uniprot O81153 610
type: UnificationXref
id: O81153
db: uniprot

Stress-activated protein kinase JNK
type: ProteinReference
xref: PTHR24055:SF341
xref: uniprot P92208 439
organism: Drosophila melanogaster

uniprot Q6PC29 1065
type: UnificationXref
id: Q6PC29
db: uniprot

uniprot F7DYR4 572
type: UnificationXref
id: F7DYR4
db: uniprot

uniprot H9EP27 1137
type: UnificationXref
id: H9EP27
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF16
xref: uniprot Q5ZKJ2 1059
organism: Gallus gallus

Cullin
type: ProteinReference
xref: uniprot F0Z8D7 1079
xref: PTHR11932:SF156
organism: Dictyostelium purpureum

Casein kinase 1, alpha 1
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot Q8JHE0 1177
organism: Danio rerio

uniprot A7F3M0 270
type: UnificationXref
id: A7F3M0
db: uniprot

uniprot F6WA79 986
type: UnificationXref
id: F6WA79
db: uniprot

uniprot Q80Y86 318
type: UnificationXref
id: Q80Y86
db: uniprot

Proteasome subunit beta type-3
type: ProteinReference
xref: uniprot Q9XYN7 731
xref: PTHR11599:SF62
organism: Drosophila melanogaster

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF407
xref: uniprot F6UTP2 770
organism: Xenopus tropicalis

Parkin
type: Protein
entity reference: Parkin
feature: COMPLEX PARTICIPANT BINDING FEATURE s111 sa39 1256
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

N Y125 s76 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: N Y125
stoichiometric coefficient: 1.0

Predicted protein
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot A9U4N3 57
organism: Physcomitrella patens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CZ86 89
xref: PTHR19375:SF210
organism: Macaca mulatta

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
type: ProteinReference
xref: uniprot Q28DR3 1046
xref: PTHR18860:SF16
organism: Xenopus tropicalis

Src kinase
type: ProteinReference
xref: P01230
standard name: Src tyrosine kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.Src kinase
comment: ENTITY_REFERENCE_NOTES= Long Name: Rous sarcoma protein tyrosine kinase Synonym: Synonym not specified Accession: P01230
member entity reference: Tyrosine-protein kinase
member entity reference: Tyrosine-protein kinase Fgr
member entity reference: Proto-oncogene tyrosine-protein kinase Src
member entity reference: Tyrosine-protein kinase Fyn
member entity reference: Tyrosine-protein kinase fynb
member entity reference: Tyrosine-protein kinase CSK
member entity reference: Tyrosine-protein kinase HCK
member entity reference: Tyrosine-protein kinase Yes
member entity reference: Neuronal proto-oncogene tyrosine-protein kinase Src
member entity reference: Tyrosine-protein kinase Blk
member entity reference: Proto-oncogene tyrosine-protein kinase LCK
member entity reference: Tyrosine-protein kinase FRK
member entity reference: Tyrosine-protein kinase Lck
member entity reference: Tyrosine-protein kinase Src42A
member entity reference: Tyrosine-protein kinase Lyn
member entity reference: Tyrosine-protein kinase fyna
member entity reference: Tyrosine-protein kinase (Fragment)
member entity reference: Tyrosine-protein kinase Src64B

uniprot E2RKT9 483
type: UnificationXref
id: E2RKT9
db: uniprot

PTHR24355:SF17
type: RelationshipXref
id: PTHR24355:SF17
db: PANTHER Family
relationship type: By Homology

PTHR24355:SF18
type: RelationshipXref
id: PTHR24355:SF18
db: PANTHER Family
relationship type: By Homology

Transporter
type: DnaReference
xref: PTHR11616:SF38
organism: Macaca mulatta

uniprot P62259 1028
type: UnificationXref
id: P62259
db: uniprot

Proteasome subunit beta type-4
type: ProteinReference
xref: PTHR11599:SF5
xref: uniprot Q9VNA5 728
organism: Drosophila melanogaster

uniprot Q5QNB8 1056
type: UnificationXref
id: Q5QNB8
db: uniprot

uniprot Q39022 303
type: UnificationXref
id: Q39022
db: uniprot

uniprot Q3SZI4 1048
type: UnificationXref
id: Q3SZI4
db: uniprot

uniprot Q8JHE0 1177
type: UnificationXref
id: Q8JHE0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DC98 90
xref: PTHR19375:SF379
organism: Monodelphis domestica

uniprot B7QIS2 878
type: UnificationXref
id: B7QIS2
db: uniprot

Ribosome-associated molecular chaperone SSB1
type: ProteinReference
xref: uniprot Q75E44 217
xref: PTHR19375:SF395
organism: Ashbya gossypii

uniprot P16892 290
type: UnificationXref
id: P16892
db: uniprot

uniprot Q2YDE4 663
type: UnificationXref
id: Q2YDE4
db: uniprot

Heat shock 70 kDa protein 1A
type: ProteinReference
xref: uniprot Q61696 211
xref: PTHR19375:SF223
organism: Mus musculus

uniprot F7C1G3 1131
type: UnificationXref
id: F7C1G3
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 70

alpha Synuclein s78 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot H2QED5 584
xref: PTHR11599:SF144
organism: Pan troglodytes

uniprot P11142 131
type: UnificationXref
id: P11142
db: uniprot

uniprot P42645 1017
type: UnificationXref
id: P42645
db: uniprot

uniprot Q7SXN6 702
type: UnificationXref
id: Q7SXN6
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot Q6DGX8 683
xref: PTHR11599:SF12
organism: Danio rerio

uniprot Q9XYW6 366
type: UnificationXref
id: Q9XYW6
db: uniprot

S129 alpha Synuclein s39 a56 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S129
feature location: S129 alpha Synuclein s39 a56 rs1 S129
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S129
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

Uncharacterized protein
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot F7C1G3 1131
organism: Monodelphis domestica

uniprot Q9LDZ0 245
type: UnificationXref
id: Q9LDZ0
db: uniprot

uniprot H2QHF1 1001
type: UnificationXref
id: H2QHF1
db: uniprot

Proteasome subunit alpha type-2
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot P23639 625
organism: Saccharomyces cerevisiae

uniprot Q9CAI5 1188
type: UnificationXref
id: Q9CAI5
db: uniprot

Proteasome subunit alpha type-3
type: ProteinReference
xref: PTHR11599:SF13
xref: uniprot P23638 624
organism: Saccharomyces cerevisiae

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot G2HIX7 579
organism: Pan troglodytes

mitochondrion
type: CellularLocationVocabulary
xref: GO GO:0005739 3

PARTICIPANT STOICHIOMETRY r18 1291
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot A8WY28 533
organism: Caenorhabditis briggsae

PARTICIPANT STOICHIOMETRY r18 1292
type: Stoichiometry
physical entity: a1_degraded
stoichiometric coefficient: 1.0

uniprot H2QLB4 284
type: UnificationXref
id: H2QLB4
db: uniprot

uniprot F6YL96 361
type: UnificationXref
id: F6YL96
db: uniprot

uniprot P63086 297
type: UnificationXref
id: P63086
db: uniprot

Pael-R
type: Protein
entity reference: Pael-R
feature: Pael R s44 sa16 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s44 sa16 1276
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

ARTA
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot Q5B4M9 1049
organism: Emericella nidulans

eco ECO:0000353 379
type: UnificationXref
id: ECO:0000353
db: eco

Protein CBR-PAR-5
type: ProteinReference
xref: uniprot A8X0R4 968
xref: PTHR18860:SF21
organism: Caenorhabditis briggsae

uniprot Q54QB1 309
type: UnificationXref
id: Q54QB1
db: uniprot

uniprot Q62844 818
type: UnificationXref
id: Q62844
db: uniprot

PTHR24355:SF22
type: RelationshipXref
id: PTHR24355:SF22
db: PANTHER Family
relationship type: By Homology

uniprot P92177 1040
type: UnificationXref
id: P92177
db: uniprot

Proteasome subunit beta
type: ProteinReference
xref: uniprot Q9LST8 715
xref: PTHR11599:SF44
organism: Oryza sativa

Tyrosine-protein kinase Lyn
type: ProteinReference
xref: PTHR24418:SF42
xref: uniprot P07948 794
organism: Homo sapiens

Tyrosine-protein kinase Yes
type: ProteinReference
xref: PTHR24418:SF90
xref: uniprot P07947 793
organism: Homo sapiens

Heat shock protein family A (Hsp70) member 5
type: ProteinReference
xref: uniprot F6S4U9 77
xref: PTHR19375:SF144
organism: Ornithorhynchus anatinus

CCNE1 isoform 1
type: ProteinReference
xref: uniprot A0A2I3TEU6 346
xref: PTHR10177:SF71
organism: Pan troglodytes

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: TRANSPORT_LEFT__MPP_PLUS_-RIGHT__MPP_PLUS_-_r3
control type: ACTIVATION
controller: DAT

uniprot F7E823 280
type: UnificationXref
id: F7E823
db: uniprot

CSNK1G3 isoform 8
type: ProteinReference
xref: uniprot A0A2I3TNT3 1117
xref: PTHR11909:SF151
organism: Pan troglodytes

uniprot P40235 1149
type: UnificationXref
id: P40235
db: uniprot

DISSOCIATION_LEFT__Complex__19S_proteasome_20S_proteasome_-RIGHT__20S_proteasome-_19S_proteasome-_r21
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 1385
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 1383
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 1384
left: Complex (19S proteasome/20S proteasome)
interaction type: DISSOCIATION
right: 19S proteasome
right: 20S proteasome

Torsin-1A
type: ProteinReference
xref: PTHR10760:SF15
xref: uniprot O14656 455
organism: Homo sapiens

14-3-3 protein epsilon
type: ProteinReference
xref: uniprot P62260 1029
xref: PTHR18860:SF17
organism: Rattus norvegicus

14-3-3 protein epsilon
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot P62261 1030
organism: Bos taurus

Proteasome subunit alpha type-5
type: ProteinReference
xref: uniprot Q9LSU1 717
xref: PTHR11599:SF14
organism: Oryza sativa

Proteasome subunit alpha type-6
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot Q9LSU3 718
organism: Oryza sativa

Probable casein kinase II subunit beta-2
type: ProteinReference
xref: uniprot O94281 902
xref: PTHR11740:SF24
organism: Schizosaccharomyces pombe

14-3-3 protein epsilon
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot P62259 1028
organism: Mus musculus

Proteasome subunit alpha type-3
type: ProteinReference
xref: PTHR11599:SF10
xref: uniprot Q9LSU0 716
organism: Oryza sativa

14-3-3 protein epsilon
type: ProteinReference
xref: PTHR18860:SF67
xref: uniprot P62258 1027
organism: Homo sapiens

Y125 alpha Synuclein s29 sa4 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y125
feature location: Y125 alpha Synuclein s29 sa4 rs2 Y125
comment: MODIFICATION_RESIDUE_NAME=Y125
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.69

NADH-quinone oxidoreductase subunit E
type: ProteinReference
xref: uniprot Q9I0J8 956
xref: PTHR10371:SF3
organism: Pseudomonas aeruginosa

uniprot P34066 636
type: UnificationXref
id: P34066
db: uniprot

Yarrowia lipolytica
type: BioSource
xref: ncbitaxon 284591 239

F-box/WD repeat-containing protein 7
type: ProteinReference
xref: uniprot Q8VBV4 1104
organism: Mus musculus

uniprot A2EQB9 33
type: UnificationXref
id: A2EQB9
db: uniprot

uniprot P52428 647
type: UnificationXref
id: P52428
db: uniprot

uniprot Q5ZLQ6 1060
type: UnificationXref
id: Q5ZLQ6
db: uniprot

uniprot F6ZXI7 87
type: UnificationXref
id: F6ZXI7
db: uniprot

Heat shock protein 70A
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot A8JEU4 44
organism: Chlamydomonas reinhardtii

Chaperone protein DnaK
type: ProteinReference
xref: uniprot Q8RH05 230
xref: PTHR19375:SF184
organism: Fusobacterium nucleatum

uniprot Q61457 357
type: UnificationXref
id: Q61457
db: uniprot

UCH-L1
type: Protein
entity reference: UCH-L1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

alpha Synuclein s39 a56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 8.0

uniprot Q9LID3 1192
type: UnificationXref
id: Q9LID3
db: uniprot

uniprot F6XZS3 567
type: UnificationXref
id: F6XZS3
db: uniprot

uniprot P11147 133
type: UnificationXref
id: P11147
db: uniprot

uniprot Q9LM33 325
type: UnificationXref
id: Q9LM33
db: uniprot

Peripheral plasma membrane protein CASK
type: ProteinReference
xref: PTHR23122:SF40
xref: uniprot O70589 843
organism: Mus musculus

TH
type: Protein
entity reference: TH
feature: COMPLEX PARTICIPANT BINDING FEATURE s97 sa32 1240
feature: TH s97 sa32 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot P11021 129
type: UnificationXref
id: P11021
db: uniprot

uniprot Q6P073 469
type: UnificationXref
id: Q6P073
db: uniprot

Tyrosine-protein kinase fynb
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot F1RDG9 766
organism: Danio rerio

uniprot Q84TA1 222
type: UnificationXref
id: Q84TA1
db: uniprot

uniprot F1N261 765
type: UnificationXref
id: F1N261
db: uniprot

MPP+
type: SmallMolecule
cellular location: intracellular
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Mitogen-activated protein kinase 10
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot Q61831 440
organism: Mus musculus

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot A0A1D5RHS9 530
xref: PTHR11599:SF10
organism: Macaca mulatta

G1/S-specific cyclin-E1
type: ProteinReference
xref: uniprot F1NQ71 349
xref: PTHR10177:SF71
organism: Gallus gallus

uniprot P34119 637
type: UnificationXref
id: P34119
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6WMM9 84
xref: PTHR19375:SF144
organism: Monodelphis domestica

uniprot O04378 377
type: UnificationXref
id: O04378
db: uniprot

19S proteasome
type: Protein
entity reference: 19S proteasome
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa1 1278
feature: ACTIVE 21
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

alpha Synuclein s40 a57 rs3
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot P19120 145
type: UnificationXref
id: P19120
db: uniprot

uniprot A0A1D5RD87 868
type: UnificationXref
id: A0A1D5RD87
db: uniprot

uniprot K7BNT4 10
type: UnificationXref
id: K7BNT4
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot A8X8G7 534
organism: Caenorhabditis briggsae

uniprot Q9VQE3 1199
type: UnificationXref
id: Q9VQE3
db: uniprot

alpha Synuclein s40 a57 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.528611247526151

uniprot Q8VBV4 1104
type: UnificationXref
id: Q8VBV4
db: uniprot

uniprot F7H4H9 998
type: UnificationXref
id: F7H4H9
db: uniprot

Probable proteasome subunit alpha type-7
type: ProteinReference
xref: PTHR11599:SF10
xref: uniprot O59770 604
organism: Schizosaccharomyces pombe

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF3
xref: uniprot F6Y478 990
organism: Canis lupus familiaris

uniprot P25098 860
type: UnificationXref
id: P25098
db: uniprot

Proteasome subunit alpha type-7-1A
type: ProteinReference
xref: uniprot Q24178 658
xref: PTHR11599:SF15
organism: Drosophila melanogaster

uniprot F7GN93 428
type: UnificationXref
id: F7GN93
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q9FXT7 324
organism: Chlamydomonas reinhardtii

Zgc:86598
type: ProteinReference
xref: uniprot Q6IQV0 930
xref: PTHR24054:SF28
organism: Danio rerio

CASK
type: Protein
entity reference: CASK
feature: COMPLEX PARTICIPANT BINDING FEATURE s79 sa22 1204
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot O23710 598
type: UnificationXref
id: O23710
db: uniprot

uniprot F7FG65 776
type: UnificationXref
id: F7FG65
db: uniprot

ncbitaxon 184922 40
type: UnificationXref
id: 184922
db: ncbitaxon

uniprot Q5ACW5 927
type: UnificationXref
id: Q5ACW5
db: uniprot

Heat shock 70 kDa protein C
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot P27420 153
organism: Caenorhabditis elegans

uniprot P21868 910
type: UnificationXref
id: P21868
db: uniprot

uniprot Q9QYC6 749
type: UnificationXref
id: Q9QYC6
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r1
controller: Iron

PARTICIPANT STOICHIOMETRY r35 1343
type: Stoichiometry
physical entity: Elk-1
stoichiometric coefficient: 1.0

Septin-1
type: ProteinReference
xref: uniprot A5PJU9 500
organism: Bos taurus

Proteasome subunit alpha type-2-B
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot Q8L4A7 705
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r35 1344
type: Stoichiometry
physical entity: Elk-1
stoichiometric coefficient: 1.0

uniprot A0A3Q1MYA3 755
type: UnificationXref
id: A0A3Q1MYA3
db: uniprot

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 5

uniprot P25911 802
type: UnificationXref
id: P25911
db: uniprot

AGAP007643-PA
type: ProteinReference
xref: PTHR18860:SF106
xref: uniprot A0NBC2 965
organism: Anopheles gambiae

Chaperone protein DnaK
type: ProteinReference
xref: uniprot Q8TQR2 233
xref: PTHR19375:SF184
organism: Methanosarcina acetivorans

uniprot Q9FFH8 1190
type: UnificationXref
id: Q9FFH8
db: uniprot

Syntaxin-7
type: ProteinReference
xref: PTHR19957:SF90
xref: uniprot Q3ZBT5 385
organism: Bos taurus

Proteasome subunit alpha type-2
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot P40301 640
organism: Drosophila melanogaster

Proteasome subunit alpha type-6
type: ProteinReference
xref: uniprot P40302 641
xref: PTHR11599:SF12
organism: Saccharomyces cerevisiae

Proteasome subunit alpha type-4
type: ProteinReference
xref: uniprot P40303 642
xref: PTHR11599:SF15
organism: Saccharomyces cerevisiae

Proteasome subunit beta type-10
type: ProteinReference
xref: PTHR11599:SF41
xref: uniprot P40306 643
organism: Homo sapiens

Tyrosine-protein kinase Fgr
type: ProteinReference
xref: PTHR24418:SF224
xref: uniprot Q6P6U0 821
organism: Rattus norvegicus

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
type: ProteinReference
xref: uniprot P04394 946
xref: PTHR10371:SF3
organism: Bos taurus

uniprot A9SBU0 874
type: UnificationXref
id: A9SBU0
db: uniprot

Protein lin-2
type: ProteinReference
xref: PTHR23122:SF7
xref: uniprot P54936 844
organism: Caenorhabditis elegans

Casein kinase II subunit beta
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot Q84RS4 933
organism: Oryza sativa

Os05g0460000 protein
type: ProteinReference
xref: PTHR19375:SF445
xref: uniprot Q6L509 212
organism: Oryza sativa

Cytoplasmic heat shock protein 70, putative
type: ProteinReference
xref: uniprot A2EP28 32
xref: PTHR19375:SF395
organism: Trichomonas vaginalis

uniprot A8WS54 531
type: UnificationXref
id: A8WS54
db: uniprot

uniprot H2R7H0 99
type: UnificationXref
id: H2R7H0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HN06 578
xref: PTHR11599:SF5
organism: Macaca mulatta

14-3-3 protein 1
type: ProteinReference
xref: uniprot C4M323 974
xref: PTHR18860:SF106
organism: Entamoeba histolytica

uniprot Q9LHA8 246
type: UnificationXref
id: Q9LHA8
db: uniprot

19S proteasome
type: Protein
entity reference: 19S proteasome
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q8TQR2 233
type: UnificationXref
id: Q8TQR2
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E1B8P9 272
xref: PTHR24055:SF393
organism: Bos taurus

14-3-3 protein beta/alpha
type: ProteinReference
xref: uniprot P31946 1011
xref: PTHR18860:SF28
organism: Homo sapiens

14-3-3 protein sigma
type: ProteinReference
xref: PTHR18860:SF14
xref: uniprot P31947 1012
organism: Homo sapiens

Complex (Cul-1/Parkin/ hSel10)
type: Complex
component stoichiometry: hSel10 s54 sa19 STOICHIOMETRY ID COMPLEX
component stoichiometry: Parkin s46 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cul 1 s45 sa17 STOICHIOMETRY ID COMPLEX
component: hSel10
component: Cul-1
component: Parkin
feature: COMPLEX BINDING FEATURE s88 a118 1247
feature: COMPLEX BINDING FEATURE s88 a118 1251
feature: COMPLEX BINDING FEATURE s88 a118 1249
cellular location: intracellular

Casein kinase II subunit beta
type: ProteinReference
xref: uniprot P28548 911
xref: PTHR11740:SF0
organism: Caenorhabditis elegans

uniprot F6T0Y1 504
type: UnificationXref
id: F6T0Y1
db: uniprot

TRANSLATION
type: InteractionVocabulary

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 78

uniprot E9AFW0 551
type: UnificationXref
id: E9AFW0
db: uniprot

Casein kinase II subunit alpha
type: ProteinReference
xref: uniprot Q60737 928
xref: PTHR24054:SF16
organism: Mus musculus

14-3-3 family protein 7
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot Q7RVK6 1069
organism: Neurospora crassa

uniprot F1MWU9 71
type: UnificationXref
id: F1MWU9
db: uniprot

Casein kinase I
type: ProteinReference
xref: P01242
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.Casein kinase I
comment: ENTITY_REFERENCE_NOTES= Long Name: Casein kinase I Synonym: Synonym not specified Accession: P01242
member entity reference: Casein kinase I isoform delta-A
member entity reference: Casein kinase I homolog 3
member entity reference: Casein kinase I homolog 2
member entity reference: CSNK1G3 isoform 8
member entity reference: Casein kinase-like protein
member entity reference: Casein kinase I isoform epsilon
member entity reference: Protein kinase family protein
member entity reference: Casein kinase I isoform delta
member entity reference: Uncharacterized protein
member entity reference: Casein kinase 1-like protein 13
member entity reference: CSNK1G2 protein
member entity reference: Casein kinase 1 alpha 1 like
member entity reference: Casein kinase 1 alpha 1
member entity reference: Casein kinase 1-like protein 5
member entity reference: Casein kinase I isoform alpha
member entity reference: Casein kinase I homolog hhp2
member entity reference: Casein kinase I isoform delta-B
member entity reference: Casein kinase 1-like protein 2
member entity reference: Casein kinase 1 isoform 1
member entity reference: AT26486p
member entity reference: CSNK1A1L isoform 1
member entity reference: Serine/threonine protein kinase
member entity reference: FI08417p
member entity reference: Putative casein kinase I
member entity reference: Casein kinase I isoform gamma-3
member entity reference: Casein kinase I isoform gamma-2
member entity reference: Casein kinase 1-like protein 10
member entity reference: Casein kinase 1, alpha 1
member entity reference: Casein kinase I homolog hhp1
member entity reference: Casein kinase 1-like protein 8
member entity reference: Casein kinase 1-like protein 4
member entity reference: Casein kinase I isoform alpha isoform 1
member entity reference: Tau TuBulin Kinase
member entity reference: Serine/threonine-protein kinase spe-6
member entity reference: Casein kinase 1 gamma 3
member entity reference: Os01g0198200 protein
member entity reference: Casein kinase 1 epsilon
member entity reference: Casein kinase 1-like protein 7
member entity reference: Casein kinase I homolog HRR25
member entity reference: AT15039p
member entity reference: IP11482p
member entity reference: Casein kinase 1 gamma 2
member entity reference: Discs overgrown protein kinase
member entity reference: Casein kinase 1 delta
member entity reference: Protein CBG09510
member entity reference: Casein kinase 1-like protein 12
member entity reference: Casein kinase I homolog 1
member entity reference: Casein kinase 1 isoform 2
member entity reference: Casein kinase I isoform alpha-like
member entity reference: Casein kinase 1, epsilon
member entity reference: Os01g0772600 protein
member entity reference: Protein CBR-KIN-19
member entity reference: Casein kinase I isoform beta

Ubiquitin-conjugating enzyme E2 L3
type: ProteinReference
xref: PTHR24068:SF67
xref: uniprot P68037 489
organism: Mus musculus

PTHR24055:SF401
type: RelationshipXref
id: PTHR24055:SF401
db: PANTHER Family
relationship type: By Homology

Ubiquitin-conjugating enzyme E2 L3
type: ProteinReference
xref: PTHR24068:SF67
xref: uniprot P68036 488
organism: Homo sapiens

uniprot P23638 624
type: UnificationXref
id: P23638
db: uniprot

PTHR24055:SF417
type: RelationshipXref
id: PTHR24055:SF417
db: PANTHER Family
relationship type: By Homology

HSPA5 isoform 1
type: ProteinReference
xref: PTHR19375:SF380
xref: uniprot H2PYQ3 97
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF210
xref: uniprot F6Z1G9 86
organism: Monodelphis domestica

Heat shock 70 kDa protein 18
type: ProteinReference
xref: uniprot Q9C7X7 240
xref: PTHR19375:SF413
organism: Arabidopsis thaliana

Proteasome subunit alpha type-7
type: ProteinReference
xref: PTHR11599:SF40
xref: uniprot Q3ZBG0 672
organism: Bos taurus

Torsin A
type: Protein
entity reference: Torsin A
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q9R1P1 721
type: UnificationXref
id: Q9R1P1
db: uniprot

uniprot Q9UKB1 1106
type: UnificationXref
id: Q9UKB1
db: uniprot

uniprot Q38B02 666
type: UnificationXref
id: Q38B02
db: uniprot

Src kinase
type: Protein
entity reference: Src kinase
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PTHR24054:SF16
type: RelationshipXref
id: PTHR24054:SF16
db: PANTHER Family
relationship type: By Homology

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF12
xref: uniprot Q7PMD7 694
organism: Anopheles gambiae

STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_r46
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 1306
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 1305
left: ERK
interaction type: STATE_TRANSITION
right: ERK

uniprot Q90473 235
type: UnificationXref
id: Q90473
db: uniprot

uniprot P12881 614
type: UnificationXref
id: P12881
db: uniprot

ncbitaxon 321614 277
type: UnificationXref
id: 321614
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__TH_Parkin_-RIGHT__a157_degraded-_r62
controller: Complex (19S proteasome/20S proteasome)

Heat shock protein SSC1, mitochondrial
type: ProteinReference
xref: uniprot P0CS90 122
xref: PTHR19375:SF184
organism: Saccharomyces cerevisiae

Phospholipase
type: ProteinReference
xref: uniprot K7BNT4 10
xref: PTHR18896:SF121
organism: Pan troglodytes

uniprot P39987 163
type: UnificationXref
id: P39987
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
type: ProteinReference
xref: uniprot H2QUT2 1003
xref: PTHR18860:SF22
organism: Pan troglodytes

Endoplasmic reticulum chaperone BiP homolog
type: ProteinReference
xref: PTHR19375:SF157
xref: uniprot P20163 147
organism: Caenorhabditis elegans

uniprot Q38CL5 668
type: UnificationXref
id: Q38CL5
db: uniprot

SCF ubiquitin ligase complex subunit CulA, putative (AFU_orthologue AFUA_1G12960)
type: ProteinReference
xref: uniprot C8VU45 1077
xref: PTHR11932:SF81
organism: Emericella nidulans

GO GO:0008021 2
type: UnificationXref
id: GO:0008021
db: GO

Syntaxin
type: ProteinReference
xref: P01215
comment: ENTITY_REFERENCE_NOTES= Long Name: Syntaxin Synonym: Synonym not specified Accession: P01215
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.Syntaxin
member entity reference: Syntaxin-21
member entity reference: Syntaxin-7
member entity reference: Syntaxin-12
member entity reference: Uncharacterized protein
member entity reference: STX12 isoform 1
member entity reference: Protein CBR-SYX-7
member entity reference: Syntaxin 7
member entity reference: STX12 protein
member entity reference: Os01g0254900 protein
member entity reference: STX7 isoform 4
member entity reference: Syntaxin-23
member entity reference: Putative syntaxin-24
member entity reference: Syntaxin-22
member entity reference: SYntaXin

uniprot P35508 1145
type: UnificationXref
id: P35508
db: uniprot

Ubiquitin-conjugating enzyme E2 L3
type: ProteinReference
xref: PTHR24068:SF67
xref: uniprot Q3MHP1 490
organism: Bos taurus

uniprot P41240 805
type: UnificationXref
id: P41240
db: uniprot

Beta-adrenergic receptor kinase 2
type: ProteinReference
xref: PTHR24355:SF17
xref: uniprot Q3UYH7 866
organism: Mus musculus

AGAP005954-PA
type: ProteinReference
xref: PTHR24068:SF135
xref: uniprot Q7Q6A2 470
organism: Anopheles gambiae

uniprot Q9DGE1 345
type: UnificationXref
id: Q9DGE1
db: uniprot

uniprot Q5EB96 520
type: UnificationXref
id: Q5EB96
db: uniprot

ncbitaxon 9031 23
type: UnificationXref
id: 9031
db: ncbitaxon

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot Q62844 818
organism: Rattus norvegicus

ncbitaxon 6945 61
type: UnificationXref
id: 6945
db: ncbitaxon

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E2RFF7 762
xref: PTHR24418:SF407
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__TH_Parkin_-_Ub-RIGHT__Complex__TH_Parkin_-_r59
controller: UbcH8

Protein CBR-UBC-18
type: ProteinReference
xref: uniprot A8XPD5 473
organism: Caenorhabditis briggsae

S129 alpha Synuclein s1 a1 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S129
feature location: S129 alpha Synuclein s1 a1 rs1 S129
comment: MODIFICATION_RESIDUE_NAME=S129
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

Endothelin B receptor-like protein 2
type: ProteinReference
xref: uniprot F6TEF3 740
organism: Macaca mulatta

PTHR19957:SF88
type: RelationshipXref
id: PTHR19957:SF88
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MXU1 498
organism: Bos taurus

uniprot A8WY28 533
type: UnificationXref
id: A8WY28
db: uniprot

Syntaxin
type: Protein
entity reference: Syntaxin
feature: COMPLEX PARTICIPANT BINDING FEATURE s129 sa45 1288
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

Tyrosine-protein kinase CSK
type: ProteinReference
xref: uniprot P32577 803
xref: PTHR24418:SF407
organism: Rattus norvegicus

PTHR19957:SF90
type: RelationshipXref
id: PTHR19957:SF90
db: PANTHER Family
relationship type: By Homology

uniprot O60260 392
type: UnificationXref
id: O60260
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__O_glyc_alpha_Synuclein__Parkin_-_Ub-RIGHT__Complex__O_glyc_alpha_Synuclein__Parkin_-_r56
controller: UbcH8

Protein CBR-HSP-70
type: ProteinReference
xref: PTHR19375:SF207
xref: uniprot A8Y1C9 49
organism: Caenorhabditis briggsae

L-DOPA
type: SmallMolecule
cellular location: intracellular
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P48004 644
type: UnificationXref
id: P48004
db: uniprot

Ribosome-associated molecular chaperone SSB1
type: ProteinReference
xref: uniprot P11484 134
xref: PTHR19375:SF395
organism: Saccharomyces cerevisiae

Uncharacterized protein
type: ProteinReference
xref: uniprot F6R3X6 503
organism: Macaca mulatta

uniprot P63101 1031
type: UnificationXref
id: P63101
db: uniprot

alpha-Synuclein
type: Protein
entity reference: alpha-Synuclein
feature: alpha Synuclein s1 a1 rs4
feature: S129 alpha Synuclein s1 a1 rs1
feature: alpha Synuclein s1 a1 rs3
feature: Y125 alpha Synuclein s1 a1 rs2
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GQM5 507
organism: Macaca mulatta

uniprot P19784 909
type: UnificationXref
id: P19784
db: uniprot

uniprot P62261 1030
type: UnificationXref
id: P62261
db: uniprot

Tyrosine-protein kinase FRK
type: ProteinReference
xref: PTHR24418:SF419
xref: uniprot Q922K9 825
organism: Mus musculus

Tyrosine-protein kinase Src42A
type: ProteinReference
xref: uniprot Q9V9J3 826
xref: PTHR24418:SF431
organism: Drosophila melanogaster

Casein kinase I isoform delta
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot Q06486 1160
organism: Rattus norvegicus

uniprot Q8T869 232
type: UnificationXref
id: Q8T869
db: uniprot

uniprot A8XHD1 48
type: UnificationXref
id: A8XHD1
db: uniprot

Proteasome subunit alpha type-6
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot P60901 649
organism: Rattus norvegicus

Proteasome subunit alpha type-6
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot P60900 648
organism: Homo sapiens

DAT
type: DnaRegion
entity reference: Dopamine transporter
cellular location: intracellular
comment: SPECIES_TYPE=GENE

ncbitaxon 9615 68
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot H2QDJ4 509
type: UnificationXref
id: H2QDJ4
db: uniprot

Peripheral plasma membrane protein CASK
type: ProteinReference
xref: PTHR23122:SF40
xref: uniprot Q62915 846
organism: Rattus norvegicus

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 242

uniprot Q8RH05 230
type: UnificationXref
id: Q8RH05
db: uniprot

uniprot Q9I0J8 956
type: UnificationXref
id: Q9I0J8
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot A0A3Q1LJZ7 413
xref: PTHR24055:SF146
organism: Bos taurus

uniprot Q7K6A9 693
type: UnificationXref
id: Q7K6A9
db: uniprot

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot Q13164 300
xref: PTHR24055:SF356
organism: Homo sapiens

Casein kinase 2 alpha 2
type: ProteinReference
xref: PTHR24054:SF34
xref: uniprot B4F7A9 877
organism: Rattus norvegicus

uniprot P35626 864
type: UnificationXref
id: P35626
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot G1K268 94
xref: PTHR19375:SF223
organism: Canis lupus familiaris

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 37

uniprot Q02720 923
type: UnificationXref
id: Q02720
db: uniprot

alpha Synuclein s87 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

14-3-3-like protein GF14 lambda
type: ProteinReference
xref: uniprot P48349 1022
xref: PTHR18860:SF69
organism: Arabidopsis thaliana

14-3-3-like protein GF14 kappa
type: ProteinReference
xref: PTHR18860:SF112
xref: uniprot P48348 1021
organism: Arabidopsis thaliana

PTHR23122:SF40
type: RelationshipXref
id: PTHR23122:SF40
db: PANTHER Family
relationship type: By Homology

14-3-3-like protein GF14 epsilon
type: ProteinReference
xref: PTHR18860:SF72
xref: uniprot P48347 1020
organism: Arabidopsis thaliana

uniprot A0A3Q1LPV4 836
type: UnificationXref
id: A0A3Q1LPV4
db: uniprot

PTHR24055:SF356
type: RelationshipXref
id: PTHR24055:SF356
db: PANTHER Family
relationship type: By Homology

uniprot P27361 292
type: UnificationXref
id: P27361
db: uniprot

Proteasome subunit beta type-7
type: ProteinReference
xref: uniprot P70195 650
xref: PTHR11599:SF42
organism: Mus musculus

uniprot P54652 168
type: UnificationXref
id: P54652
db: uniprot

UCH-L1
type: ProteinReference
xref: P01210
standard name: Ubiquitin C-terminal hydrolase-L1
comment: ENTITY_REFERENCE_NOTES= Long Name: Ubiquitin C-terminal hydrolase-L1 Synonym: Synonym not specified Accession: P01210
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.UCH-L1
member entity reference: Ubiquitin carboxyl-terminal hydrolase isozyme L1
member entity reference: Ubiquitin carboxyl-terminal hydrolase

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

uniprot F7FVG8 1101
type: UnificationXref
id: F7FVG8
db: uniprot

alpha Synuclein s95 sa30 rs3
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot A0A1D5QEC6 526
type: UnificationXref
id: A0A1D5QEC6
db: uniprot

PTHR19375:SF418
type: RelationshipXref
id: PTHR19375:SF418
db: PANTHER Family
relationship type: By Homology

PTHR19375:SF417
type: RelationshipXref
id: PTHR19375:SF417
db: PANTHER Family
relationship type: By Homology

PTHR19375:SF413
type: RelationshipXref
id: PTHR19375:SF413
db: PANTHER Family
relationship type: By Homology

uniprot P06761 115
type: UnificationXref
id: P06761
db: uniprot

uniprot P67871 920
type: UnificationXref
id: P67871
db: uniprot

E3 ubiquitin-protein ligase parkin
type: ProteinReference
xref: PTHR11685:SF212
xref: uniprot O60260 392
organism: Homo sapiens

uniprot O81149 609
type: UnificationXref
id: O81149
db: uniprot

uniprot A0A0R4IKK9 410
type: UnificationXref
id: A0A0R4IKK9
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot F7DYR4 572
organism: Monodelphis domestica

Septin 2
type: ProteinReference
xref: uniprot F1PEK5 502
organism: Canis lupus familiaris

Cyclin E s89 a119 rs1
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

AGAP005569-PA
type: ProteinReference
xref: uniprot Q7Q707 931
xref: PTHR24054:SF0
organism: Anopheles gambiae

uniprot A7F2U3 870
type: UnificationXref
id: A7F2U3
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1PMN2 420
xref: PTHR24055:SF162
organism: Canis lupus familiaris

alpha Synuclein s95 sa30 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.528611247526151

uniprot G5ECU5 95
type: UnificationXref
id: G5ECU5
db: uniprot

PTHR24055:SF378
type: RelationshipXref
id: PTHR24055:SF378
db: PANTHER Family
relationship type: By Homology

uniprot A8HYV3 42
type: UnificationXref
id: A8HYV3
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot H2Q9W6 583
xref: PTHR11599:SF13
organism: Pan troglodytes

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot A5PKJ4 267
xref: PTHR24055:SF356
organism: Bos taurus

Heat shock protein family A (Hsp70) member 1 like
type: ProteinReference
xref: uniprot H2R7H0 99
xref: PTHR19375:SF210
organism: Pan troglodytes

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot A8X995 535
xref: PTHR11599:SF12
organism: Caenorhabditis briggsae

alpha Synuclein s13 sa8 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

PARTICIPANT STOICHIOMETRY r61 1351
type: Stoichiometry
physical entity: L-DOPA
stoichiometric coefficient: 1.0

PTHR10589:SF19
type: RelationshipXref
id: PTHR10589:SF19
db: PANTHER Family
relationship type: By Homology

uniprot A0JNB0 756
type: UnificationXref
id: A0JNB0
db: uniprot

PARTICIPANT STOICHIOMETRY r61 1350
type: Stoichiometry
physical entity: L-tyrosine
stoichiometric coefficient: 1.0

uniprot P17066 138
type: UnificationXref
id: P17066
db: uniprot

uniprot F6WNU0 563
type: UnificationXref
id: F6WNU0
db: uniprot

PTHR19375:SF431
type: RelationshipXref
id: PTHR19375:SF431
db: PANTHER Family
relationship type: By Homology

uniprot Q5ZKJ2 1059
type: UnificationXref
id: Q5ZKJ2
db: uniprot

uniprot Q2TA03 468
type: UnificationXref
id: Q2TA03
db: uniprot

uniprot C0H4V6 971
type: UnificationXref
id: C0H4V6
db: uniprot

PTHR19375:SF436
type: RelationshipXref
id: PTHR19375:SF436
db: PANTHER Family
relationship type: By Homology

uniprot Q62762 1166
type: UnificationXref
id: Q62762
db: uniprot

DISSOCIATION
type: InteractionVocabulary

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF42
xref: uniprot F1N261 765
organism: Bos taurus

Gamma-synuclein
type: ProteinReference
xref: uniprot O76070 830
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__O2-RIGHT__ROS-_r38
controller: Complex I

Chaperone protein dnaK1
type: ProteinReference
xref: uniprot Q55154 205
xref: PTHR19375:SF184
organism: Synechocystis

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot F5HEA9 276
organism: Phaeosphaeria nodorum

uniprot G2HI54 999
type: UnificationXref
id: G2HI54
db: uniprot

uniprot G5E589 580
type: UnificationXref
id: G5E589
db: uniprot

Heat shock protein SSA4
type: ProteinReference
xref: PTHR19375:SF385
xref: uniprot P22202 148
organism: Saccharomyces cerevisiae

uniprot Q04736 811
type: UnificationXref
id: Q04736
db: uniprot

Syntaxin 7
type: ProteinReference
xref: uniprot E2R4Q2 369
xref: PTHR19957:SF90
organism: Canis lupus familiaris

Elk 1 s55 a73 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Complex I
type: Protein
entity reference: Complex I
feature: ACTIVE 21
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

G protein-coupled receptor kinase
type: ProteinReference
xref: uniprot F7DR73 855
xref: PTHR24355:SF17
organism: Monodelphis domestica

uniprot P79996 438
type: UnificationXref
id: P79996
db: uniprot

Alpha-synuclein
type: ProteinReference
xref: uniprot Q3T0G8 406
xref: PTHR13820:SF5
organism: Bos taurus

uniprot Q8IHZ9 1176
type: UnificationXref
id: Q8IHZ9
db: uniprot

uniprot P47811 341
type: UnificationXref
id: P47811
db: uniprot

PARTICIPANT STOICHIOMETRY r1 1311
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

alpha-Synuclein
type: Protein
entity reference: alpha-Synuclein
feature: alpha Synuclein s40 a57 rs3
feature: Y125 alpha Synuclein s40 a57 rs2
feature: S129 alpha Synuclein s40 a57 rs1
feature: alpha Synuclein s40 a57 rs4
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PTHR19375:SF426
type: RelationshipXref
id: PTHR19375:SF426
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r1 1312
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 8.0

Y125 alpha Synuclein s50 a70 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y125
feature location: Y125 alpha Synuclein s50 a70 rs2 Y125
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y125
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.69

PTHR24055:SF341
type: RelationshipXref
id: PTHR24055:SF341
db: PANTHER Family
relationship type: By Homology

Casein kinase 1 gamma 3
type: ProteinReference
xref: uniprot J9P9W3 1138
xref: PTHR11909:SF151
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TLV2 80
xref: PTHR19375:SF184
organism: Macaca mulatta

Tyrosine-protein kinase HCK
type: ProteinReference
xref: PTHR24418:SF245
xref: uniprot P08631 796
organism: Homo sapiens

14-3-3-like protein GF14-G
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot Q5QNB8 1056
organism: Oryza sativa

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6Y4G8 423
organism: Canis lupus familiaris

Complex I
type: Protein
entity reference: Complex I
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

PTHR19375:SF457
type: RelationshipXref
id: PTHR19375:SF457
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot A5PKG9 757
xref: PTHR24418:SF224
organism: Bos taurus

uniprot Q969H0 1105
type: UnificationXref
id: Q969H0
db: uniprot

alpha Synuclein s13 sa8 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.528611247526151

STIP1 homology and U-Box containing protein 1, isoform CRA_b
type: ProteinReference
xref: PTHR46803:SF2
xref: uniprot D4A4T0 359
organism: Rattus norvegicus

Protein CBG09510
type: ProteinReference
xref: PTHR11909:SF297
xref: uniprot A8X8Y1 1120
organism: Caenorhabditis briggsae

ncbitaxon 227321 209
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot Q10NA9 186
type: UnificationXref
id: Q10NA9
db: uniprot

uniprot P43639 917
type: UnificationXref
id: P43639
db: uniprot

Heat shock 70 kDa protein 1-like
type: ProteinReference
xref: uniprot P0CB32 121
xref: PTHR19375:SF210
organism: Bos taurus

uniprot Q05558 182
type: UnificationXref
id: Q05558
db: uniprot

PTHR19375:SF442
type: RelationshipXref
id: PTHR19375:SF442
db: PANTHER Family
relationship type: By Homology

PTHR19375:SF448
type: RelationshipXref
id: PTHR19375:SF448
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UKV3 1083
xref: PTHR11932:SF81
organism: Macaca mulatta

Casein kinase I gamma
type: ProteinReference
xref: uniprot Q8WQ99 1184
xref: PTHR11909:SF155
organism: Caenorhabditis elegans

PTHR19375:SF445
type: RelationshipXref
id: PTHR19375:SF445
db: PANTHER Family
relationship type: By Homology

PTHR19375:SF447
type: RelationshipXref
id: PTHR19375:SF447
db: PANTHER Family
relationship type: By Homology

PTHR23122:SF7
type: RelationshipXref
id: PTHR23122:SF7
db: PANTHER Family
relationship type: By Homology

uniprot A8X995 535
type: UnificationXref
id: A8X995
db: uniprot

uniprot Q7QK64 954
type: UnificationXref
id: Q7QK64
db: uniprot

uniprot Q5ZKC9 1058
type: UnificationXref
id: Q5ZKC9
db: uniprot

TRANSCRIPTION
type: RelationshipTypeVocabulary

uniprot Q10KF0 655
type: UnificationXref
id: Q10KF0
db: uniprot

uniprot Q9WTX6 1092
type: UnificationXref
id: Q9WTX6
db: uniprot

uniprot Q9LUC3 328
type: UnificationXref
id: Q9LUC3
db: uniprot

a1_degraded
type: PhysicalEntity
cellular location: intracellular
comment: SPECIES_TYPE=DEGRADED

uniprot O70439 382
type: UnificationXref
id: O70439
db: uniprot

uniprot O14656 455
type: UnificationXref
id: O14656
db: uniprot

uniprot Q16143 398
type: UnificationXref
id: Q16143
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: TRANSPORT_LEFT__DA-RIGHT__DA-_r4
control type: ACTIVATION
controller: DAT

uniprot F7DC98 90
type: UnificationXref
id: F7DC98
db: uniprot

alpha-Synuclein
type: Protein
entity reference: alpha-Synuclein
feature: Y125 alpha Synuclein s87 sa25 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s87 sa25 1238
feature: alpha Synuclein s87 sa25 rs3
feature: alpha Synuclein s87 sa25 rs4
feature: S129 alpha Synuclein s87 sa25 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot A8JEU4 44
type: UnificationXref
id: A8JEU4
db: uniprot

Protein BMH2
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot P34730 1013
organism: Saccharomyces cerevisiae

uniprot F7EH19 281
type: UnificationXref
id: F7EH19
db: uniprot

uniprot Q99MK8 867
type: UnificationXref
id: Q99MK8
db: uniprot

Torsin
type: ProteinReference
xref: uniprot F6V735 451
xref: PTHR10760:SF15
organism: Canis lupus familiaris

uniprot Q9JHW0 714
type: UnificationXref
id: Q9JHW0
db: uniprot

uniprot E2RC09 761
type: UnificationXref
id: E2RC09
db: uniprot

uniprot D3ZWQ5 492
type: UnificationXref
id: D3ZWQ5
db: uniprot

uniprot Q5VRG3 681
type: UnificationXref
id: Q5VRG3
db: uniprot

Probable proteasome subunit alpha type-4
type: ProteinReference
xref: uniprot Q10329 654
xref: PTHR11599:SF15
organism: Schizosaccharomyces pombe

uniprot A7EJF2 268
type: UnificationXref
id: A7EJF2
db: uniprot

uniprot H2PYF9 783
type: UnificationXref
id: H2PYF9
db: uniprot

PARTICIPANT STOICHIOMETRY r60 1354
type: Stoichiometry
physical entity: Complex (TH/Parkin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 1310
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

Tyrosine-protein kinase Yes
type: ProteinReference
xref: PTHR24418:SF90
xref: uniprot P09324 797
organism: Gallus gallus

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF417
xref: uniprot Q6Z437 315
organism: Oryza sativa

PARTICIPANT STOICHIOMETRY r60 1352
type: Stoichiometry
physical entity: TH
stoichiometric coefficient: 1.0

Os01g0772600 protein
type: ProteinReference
xref: uniprot Q8S1J0 1181
xref: PTHR11909:SF329
organism: Oryza sativa

PARTICIPANT STOICHIOMETRY r60 1353
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

uniprot G3V7P1 374
type: UnificationXref
id: G3V7P1
db: uniprot

PTHR10177:SF70
type: RelationshipXref
id: PTHR10177:SF70
db: PANTHER Family
relationship type: By Homology

Phospholipase D2
type: ProteinReference
xref: uniprot P97813 17
xref: PTHR18896:SF121
organism: Mus musculus

uniprot Q7PX08 1068
type: UnificationXref
id: Q7PX08
db: uniprot

PTHR10177:SF71
type: RelationshipXref
id: PTHR10177:SF71
db: PANTHER Family
relationship type: By Homology

Phospholipase D2
type: ProteinReference
xref: uniprot Q0V8L6 19
xref: PTHR18896:SF121
organism: Bos taurus

AT21479p
type: ProteinReference
xref: PTHR10371:SF3
xref: uniprot Q9VVF0 959
organism: Drosophila melanogaster

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ub-_Complex__Parkin_Pael_R_-RIGHT__Complex__Parkin_Pael_R_-_r49
controller: Ubc6

uniprot P0DMW0 125
type: UnificationXref
id: P0DMW0
db: uniprot

uniprot Q6EUP4 1063
type: UnificationXref
id: Q6EUP4
db: uniprot

uniprot H2QTL3 784
type: UnificationXref
id: H2QTL3
db: uniprot

uniprot Q7Q7Y8 221
type: UnificationXref
id: Q7Q7Y8
db: uniprot

ncbitaxon 7739 880
type: UnificationXref
id: 7739
db: ncbitaxon

Mitogen-activated protein kinase 7
type: ProteinReference
xref: PTHR24055:SF356
xref: uniprot P0C865 288
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r45 1309
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

uniprot P42685 807
type: UnificationXref
id: P42685
db: uniprot

Synphilin-1
type: ProteinReference
xref: PTHR22882:SF3
xref: uniprot Q99ME3 494
organism: Mus musculus

SEPT5 isoform 5
type: ProteinReference
xref: uniprot A0A2J8Q2A9 497
xref: PTHR18884:SF68
organism: Pan troglodytes

eco ECO:0000250 8
type: UnificationXref
id: ECO:0000250
db: eco

uniprot A0A1D5NXQ4 1113
type: UnificationXref
id: A0A1D5NXQ4
db: uniprot

UbcH7
type: ProteinReference
xref: P01224
standard name: ubiquitin-conjugating enzyme E2L3
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.UbcH7
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: ubiquitin-conjugating enzyme E2L3 Synonym: Synonym not specified Accession: P01224
member entity reference: Ubiquitin-conjugating enzyme E2 L3
member entity reference: Ubiquitin conjugating enzyme E2 L5
member entity reference: Ubiquitin-conjugating enzyme E2L 3a
member entity reference: Uncharacterized protein

Proteasome subunit alpha type-4
type: ProteinReference
xref: uniprot P21670 622
xref: PTHR11599:SF13
organism: Rattus norvegicus

uniprot P40231 915
type: UnificationXref
id: P40231
db: uniprot

uniprot P49186 434
type: UnificationXref
id: P49186
db: uniprot

Casein kinase 1-like protein 8
type: ProteinReference
xref: PTHR11909:SF388
xref: uniprot Q9LSX4 1193
organism: Arabidopsis thaliana

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A0A0R4IKK9 410
organism: Danio rerio

ncbitaxon 9606 13
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot F6RIX6 982
type: UnificationXref
id: F6RIX6
db: uniprot

Beta-adrenergic receptor kinase 1
type: ProteinReference
xref: PTHR24355:SF22
xref: uniprot Q99MK8 867
organism: Mus musculus

STX12 isoform 1
type: ProteinReference
xref: PTHR19957:SF88
xref: uniprot H2PYG1 375
organism: Pan troglodytes

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot F7C9K3 570
organism: Ornithorhynchus anatinus

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

uniprot F7EIC6 506
type: UnificationXref
id: F7EIC6
db: uniprot

uniprot P10591 127
type: UnificationXref
id: P10591
db: uniprot

Tyrosine 3-monooxygenase
type: ProteinReference
xref: uniprot P07101 1110
xref: PTHR11473:SF18
organism: Homo sapiens

ncbitaxon 1111708 150
type: UnificationXref
id: 1111708
db: ncbitaxon

uniprot P40236 1150
type: UnificationXref
id: P40236
db: uniprot

uniprot Q5CZQ1 1050
type: UnificationXref
id: Q5CZQ1
db: uniprot

Heat shock protein 70
type: ProteinReference
xref: uniprot Q8II24 228
xref: PTHR19375:SF184
organism: Plasmodium falciparum

Leishmania major
type: BioSource
xref: ncbitaxon 5664 196

uniprot Q9VVF0 959
type: UnificationXref
id: Q9VVF0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G4T9 92
xref: PTHR19375:SF184
organism: Monodelphis domestica

Hsp70 family ATPase
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot Q5A397 207
organism: Candida albicans

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF22
xref: uniprot A0A1D5QXI6 851
organism: Macaca mulatta

G protein-coupled receptor 37
type: ProteinReference
xref: PTHR46216:SF3
xref: uniprot H2QVB0 743
organism: Pan troglodytes

uniprot H2Q8D7 582
type: UnificationXref
id: H2Q8D7
db: uniprot

14-3-3 protein epsilon
type: ProteinReference
xref: uniprot G2HI54 999
xref: PTHR18860:SF67
organism: Pan troglodytes

STATE_TRANSITION_LEFT__Ub-_Parkin-RIGHT__Complex__Synphilin_Parkin_-_r43
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 1319
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 1318
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 1317
left: Ub
left: Parkin
interaction type: STATE_TRANSITION
right: Complex (Synphilin/Parkin)

uniprot Q38AI6 301
type: UnificationXref
id: Q38AI6
db: uniprot

Torsin
type: ProteinReference
xref: uniprot Q9XXG5 462
xref: PTHR10760:SF2
organism: Caenorhabditis elegans

uniprot A0A2I3TMT4 753
type: UnificationXref
id: A0A2I3TMT4
db: uniprot

Proteasome subunit beta type-7
type: ProteinReference
xref: uniprot Q9JHW0 714
xref: PTHR11599:SF42
organism: Rattus norvegicus

SAPK
type: ProteinReference
xref: P01219
standard name: Stress-activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Stress-activated protein kinase Synonym: JNK Accession: P01219
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.SAPK
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 12
member entity reference: Stress-activated protein kinase JNK
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Mitogen-activated protein kinase hog1
member entity reference: Stress-activated protein kinase jnk-1
member entity reference: Mitogen-activated protein kinase 10

alpha Synuclein s1 a1 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF224
xref: uniprot H2PYF9 783
organism: Pan troglodytes

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot F7GN93 428
organism: Macaca mulatta

uniprot Q13164 300
type: UnificationXref
id: Q13164
db: uniprot

Gamma-synuclein
type: ProteinReference
xref: uniprot Q28F65 831
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r4 1300
type: Stoichiometry
physical entity: DA
stoichiometric coefficient: 1.0

uniprot F1PCZ0 501
type: UnificationXref
id: F1PCZ0
db: uniprot

uniprot Q2R2W2 1047
type: UnificationXref
id: Q2R2W2
db: uniprot

Casein kinase II subunit alpha'
type: ProteinReference
xref: uniprot O54833 897
xref: PTHR24054:SF34
organism: Mus musculus

ncbitaxon 665079 269
type: UnificationXref
id: 665079
db: ncbitaxon

Tyrosine-protein kinase Lyn
type: ProteinReference
xref: PTHR24418:SF42
xref: uniprot Q07014 813
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r28
controller: UCH-L1

alpha Synuclein s1 a1 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.528611247526151

PTHR24055:SF79
type: RelationshipXref
id: PTHR24055:SF79
db: PANTHER Family
relationship type: By Homology

uniprot A2FNS7 35
type: UnificationXref
id: A2FNS7
db: uniprot

Probable mediator of RNA polymerase II transcription subunit 37b
type: ProteinReference
xref: PTHR19375:SF215
xref: uniprot Q8H1B3 224
organism: Arabidopsis thaliana

uniprot Q9ZUP4 1202
type: UnificationXref
id: Q9ZUP4
db: uniprot

Peripheral plasma membrane protein CASK
type: ProteinReference
xref: PTHR23122:SF7
xref: uniprot Q24210 845
organism: Drosophila melanogaster

uniprot P22358 149
type: UnificationXref
id: P22358
db: uniprot

uniprot P67827 1156
type: UnificationXref
id: P67827
db: uniprot

alpha-Synuclein
type: Protein
entity reference: alpha-Synuclein
feature: alpha Synuclein s41 a58 rs4
feature: Y125 alpha Synuclein s41 a58 rs2
feature: S129 alpha Synuclein s41 a58 rs1
feature: alpha Synuclein s41 a58 rs3
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Parkin s37 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

uniprot Q39024 305
type: UnificationXref
id: Q39024
db: uniprot

uniprot H2QTR3 376
type: UnificationXref
id: H2QTR3
db: uniprot

Y125 alpha Synuclein s18 a21 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y125
feature location: Y125 alpha Synuclein s18 a21 rs2 Y125
comment: MODIFICATION_RESIDUE_NAME=Y125
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.69

PARTICIPANT STOICHIOMETRY r68 1340
type: Stoichiometry
physical entity: Complex (CDCrel-1/Parkin)
stoichiometric coefficient: 1.0

a173_degraded
type: PhysicalEntity
cellular location: intracellular
comment: SPECIES_TYPE=DEGRADED

Casein kinase 1 epsilon
type: ProteinReference
xref: uniprot Q5XGI6 1164
xref: PTHR11909:SF18
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SAPK-RIGHT__SAPK-_r36
controller: alpha-Synuclein

Heat shock protein SSA1
type: ProteinReference
xref: PTHR19375:SF426
xref: uniprot P41797 165
organism: Candida albicans

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot F6TY10 985
organism: Monodelphis domestica

Complex (O-glyc/alpha-Synuclein)
type: Complex
component stoichiometry: alpha Synuclein s87 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: O glyc s86 sa24 STOICHIOMETRY ID COMPLEX
component: alpha-Synuclein
component: O-glyc
feature: COMPLEX BINDING FEATURE s105 a133 1235
feature: COMPLEX BINDING FEATURE s105 a133 1237
cellular location: intracellular

uniprot O96999 1141
type: UnificationXref
id: O96999
db: uniprot

PTHR11599:SF59
type: RelationshipXref
id: PTHR11599:SF59
db: PANTHER Family
relationship type: By Homology

Protein CBR-HSP-6
type: ProteinReference
xref: uniprot A8X7H4 47
xref: PTHR19375:SF184
organism: Caenorhabditis briggsae

alpha-Synuclein
type: Protein
entity reference: alpha-Synuclein
feature: alpha Synuclein s29 sa4 rs3
feature: S129 alpha Synuclein s29 sa4 rs1
feature: alpha Synuclein s29 sa4 rs4
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa4 1214
feature: Y125 alpha Synuclein s29 sa4 rs2
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PTHR11599:SF62
type: RelationshipXref
id: PTHR11599:SF62
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r68 1339
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r68 1338
type: Stoichiometry
physical entity: CDCrel-1
stoichiometric coefficient: 1.0

uniprot F6TBG4 1128
type: UnificationXref
id: F6TBG4
db: uniprot

GO GO:0005783 5
type: UnificationXref
id: GO:0005783
db: GO

Uncharacterized protein
type: ProteinReference
xref: PTHR24054:SF16
xref: uniprot A0A1D5RD87 868
organism: Macaca mulatta

uniprot Q57X58 678
type: UnificationXref
id: Q57X58
db: uniprot

PTHR11599:SF44
type: RelationshipXref
id: PTHR11599:SF44
db: PANTHER Family
relationship type: By Homology

alpha-Synuclein
type: Protein
entity reference: alpha-Synuclein
feature: alpha Synuclein s39 a56 rs3
feature: alpha Synuclein s39 a56 rs4
feature: Y125 alpha Synuclein s39 a56 rs2
feature: S129 alpha Synuclein s39 a56 rs1

uniprot P07947 793
type: UnificationXref
id: P07947
db: uniprot

Syntaxin
type: Protein
entity reference: Syntaxin
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot Q6ZKC0 1066
type: UnificationXref
id: Q6ZKC0
db: uniprot

ncbitaxon 64091 242
type: UnificationXref
id: 64091
db: ncbitaxon

Casein kinase I isoform delta
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot Q6P647 1170
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__O2-RIGHT__H2O2-_r39
controller: Complex I

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot H9GW49 104
organism: Canis lupus familiaris

uniprot Q9DGD9 444
type: UnificationXref
id: Q9DGD9
db: uniprot

uniprot P32577 803
type: UnificationXref
id: P32577
db: uniprot

uniprot O64817 899
type: UnificationXref
id: O64817
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__CDCrel_1_Parkin_-RIGHT__Complex__CDCrel_1_Parkin_-_r69
controller: UbcH7

ncbitaxon 39947 187
type: UnificationXref
id: 39947
db: ncbitaxon

Ubiquitin carboxyl-terminal hydrolase
type: ProteinReference
xref: uniprot F7H5G4 259
xref: PTHR10589:SF19
organism: Macaca mulatta

Casein kinase 2 alpha 2
type: ProteinReference
xref: uniprot F6RN85 889
xref: PTHR24054:SF34
organism: Xenopus tropicalis

Parkin
type: Protein
entity reference: Parkin
feature: COMPLEX PARTICIPANT BINDING FEATURE s36 sa12 1222
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PTHR11599:SF40
type: RelationshipXref
id: PTHR11599:SF40
db: PANTHER Family
relationship type: By Homology

PTHR11599:SF41
type: RelationshipXref
id: PTHR11599:SF41
db: PANTHER Family
relationship type: By Homology

PTHR11599:SF42
type: RelationshipXref
id: PTHR11599:SF42
db: PANTHER Family
relationship type: By Homology

uniprot O61443 339
type: UnificationXref
id: O61443
db: uniprot

uniprot E2RFF7 762
type: UnificationXref
id: E2RFF7
db: uniprot

uniprot Q9CQV8 1074
type: UnificationXref
id: Q9CQV8
db: uniprot

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot Q7Q797 701
xref: PTHR11599:SF15
organism: Anopheles gambiae

uniprot P18422 618
type: UnificationXref
id: P18422
db: uniprot

uniprot Q3ZCK9 673
type: UnificationXref
id: Q3ZCK9
db: uniprot

uniprot Q9QYC5 748
type: UnificationXref
id: Q9QYC5
db: uniprot

uniprot Q7ZW20 1071
type: UnificationXref
id: Q7ZW20
db: uniprot

uniprot Q9LST8 715
type: UnificationXref
id: Q9LST8
db: uniprot

uniprot Q9LQQ9 327
type: UnificationXref
id: Q9LQQ9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot F7H1B9 93
organism: Macaca mulatta

PTHR11599:SF11
type: RelationshipXref
id: PTHR11599:SF11
db: PANTHER Family
relationship type: By Homology

PTHR11599:SF12
type: RelationshipXref
id: PTHR11599:SF12
db: PANTHER Family
relationship type: By Homology

PTHR11599:SF13
type: RelationshipXref
id: PTHR11599:SF13
db: PANTHER Family
relationship type: By Homology

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF22
xref: uniprot E2R5J6 853
organism: Canis lupus familiaris

PTHR11599:SF14
type: RelationshipXref
id: PTHR11599:SF14
db: PANTHER Family
relationship type: By Homology

PTHR11599:SF15
type: RelationshipXref
id: PTHR11599:SF15
db: PANTHER Family
relationship type: By Homology

PTHR11599:SF16
type: RelationshipXref
id: PTHR11599:SF16
db: PANTHER Family
relationship type: By Homology

a119_degraded
type: PhysicalEntity
cellular location: intracellular
comment: SPECIES_TYPE=DEGRADED

STATE_TRANSITION_LEFT__Complex_I-RIGHT__Complex_I-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 1290
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 1289
left: Complex I
interaction type: STATE_TRANSITION
right: Complex I

uniprot P16627 137
type: UnificationXref
id: P16627
db: uniprot

uniprot A8Y1C9 49
type: UnificationXref
id: A8Y1C9
db: uniprot

uniprot P19404 949
type: UnificationXref
id: P19404
db: uniprot

uniprot Q5EBB0 1051
type: UnificationXref
id: Q5EBB0
db: uniprot

Proteasome subunit beta type-3
type: ProteinReference
xref: uniprot Q9R1P1 721
xref: PTHR11599:SF62
organism: Mus musculus

Proteasome subunit alpha type-4
type: ProteinReference
xref: uniprot Q9R1P0 720
xref: PTHR11599:SF13
organism: Mus musculus

Proteasome subunit alpha type-1
type: ProteinReference
xref: uniprot Q9R1P4 722
xref: PTHR11599:SF12
organism: Mus musculus

PTHR11599:SF10
type: RelationshipXref
id: PTHR11599:SF10
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase Lyn
type: ProteinReference
xref: PTHR24418:SF42
xref: uniprot P25911 802
organism: Mus musculus

Casein kinase 1 alpha 1 like
type: ProteinReference
xref: uniprot F7AM42 1130
xref: PTHR11909:SF139
organism: Macaca mulatta

ncbitaxon 45351 872
type: UnificationXref
id: 45351
db: ncbitaxon

IP11482p
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot Q9VQE3 1199
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF3
xref: uniprot E2REA4 976
organism: Canis lupus familiaris

Chaperone protein DnaK
type: ProteinReference
xref: uniprot P9WMJ9 179
xref: PTHR19375:SF184
organism: Mycobacterium tuberculosis

uniprot K7B2K4 858
type: UnificationXref
id: K7B2K4
db: uniprot

Casein kinase 1 alpha 1
type: ProteinReference
xref: uniprot F6VPH2 1129
xref: PTHR11909:SF20
organism: Xenopus tropicalis

ROS
type: SmallMolecule
cellular location: mitochondrion
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot H2QKQ2 585
xref: PTHR11599:SF40
organism: Pan troglodytes

Proteasome subunit beta
type: ProteinReference
xref: uniprot G5E589 580
xref: PTHR11599:SF59
organism: Bos taurus

uniprot Q9DC28 1189
type: UnificationXref
id: Q9DC28
db: uniprot

uniprot A0A1D5QUZ8 266
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F7B5L8 426
organism: Ornithorhynchus anatinus

alpha Synuclein s13 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

Syntaxin-7
type: ProteinReference
xref: PTHR19957:SF90
xref: uniprot O70257 381
organism: Rattus norvegicus

uniprot H9GW49 104
type: UnificationXref
id: H9GW49
db: uniprot

Ubc7
type: Protein
entity reference: Ubc7
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

E3 ubiquitin-protein ligase parkin
type: ProteinReference
xref: PTHR11685:SF212
xref: uniprot H2QU08 391
organism: Pan troglodytes

uniprot P16277 801
type: UnificationXref
id: P16277
db: uniprot

PARTICIPANT STOICHIOMETRY r21 1385
type: Stoichiometry
physical entity: 19S proteasome
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r21 1384
type: Stoichiometry
physical entity: 20S proteasome
stoichiometric coefficient: 1.0

Cytoplasmic heat shock protein 70, putative
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot A2EY23 34
organism: Trichomonas vaginalis

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 141

PTHR11740:SF24
type: RelationshipXref
id: PTHR11740:SF24
db: PANTHER Family
relationship type: By Homology

PTHR11740:SF22
type: RelationshipXref
id: PTHR11740:SF22
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r21 1383
type: Stoichiometry
physical entity: Complex (19S proteasome/20S proteasome)
stoichiometric coefficient: 1.0

PTHR11740:SF21
type: RelationshipXref
id: PTHR11740:SF21
db: PANTHER Family
relationship type: By Homology

PTHR11740:SF30
type: RelationshipXref
id: PTHR11740:SF30
db: PANTHER Family
relationship type: By Homology

Complex (CDCrel-1/Syntaxin)
type: Complex
component stoichiometry: Syntaxin s129 sa45 STOICHIOMETRY ID COMPLEX
component stoichiometry: CDCrel 1 s128 sa44 STOICHIOMETRY ID COMPLEX
component: CDCrel-1
component: Syntaxin
feature: COMPLEX BINDING FEATURE s124 a180 1287
feature: COMPLEX BINDING FEATURE s124 a180 1285
cellular location: synaptic vesicle

uniprot P61145 405
type: UnificationXref
id: P61145
db: uniprot

uniprot H2QS62 429
type: UnificationXref
id: H2QS62
db: uniprot

uniprot H2QU28 586
type: UnificationXref
id: H2QU28
db: uniprot

alpha-Synuclein
type: Protein
entity reference: alpha-Synuclein
feature: alpha Synuclein s50 a70 rs4
feature: Y125 alpha Synuclein s50 a70 rs2
feature: S129 alpha Synuclein s50 a70 rs1
feature: alpha Synuclein s50 a70 rs3
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Complex (Synphilin/Parkin)
type: Complex
component stoichiometry: Synphilin s34 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Parkin s36 sa12 STOICHIOMETRY ID COMPLEX
component: Synphilin
component: Parkin
feature: COMPLEX BINDING FEATURE s66 a92 1221
feature: COMPLEX BINDING FEATURE s66 a92 1219
cellular location: intracellular

uniprot P06241 792
type: UnificationXref
id: P06241
db: uniprot

uniprot Q8T3S5 936
type: UnificationXref
id: Q8T3S5
db: uniprot

uniprot A9JTJ5 50
type: UnificationXref
id: A9JTJ5
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Parkin-_Complex__O_glyc_alpha_Synuclein_-RIGHT__Complex__O_glyc_alpha_Synuclein__Parkin_-_r57
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 1366
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 1368
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 1367
left: Complex (O-glyc/alpha-Synuclein)
left: Parkin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (O-glyc/alpha-Synuclein/ Parkin)

Casein kinase I isoform epsilon
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot F6R2T7 1126
organism: Macaca mulatta

uniprot Q39026 306
type: UnificationXref
id: Q39026
db: uniprot

uniprot P17879 144
type: UnificationXref
id: P17879
db: uniprot

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 112

uniprot Q28923 815
type: UnificationXref
id: Q28923
db: uniprot

AGAP010876-PA (Fragment)
type: ProteinReference
xref: uniprot Q7PFH8 219
xref: PTHR19375:SF184
organism: Anopheles gambiae

Y125 alpha Synuclein s95 sa30 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y125
feature location: Y125 alpha Synuclein s95 sa30 rs2 Y125
comment: MODIFICATION_RESIDUE_NAME=Y125
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.69

p38 MAPK
type: Protein
entity reference: p38 MAPK
feature: ACTIVE 21
feature: p38 MAPK s74 a99 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Alpha-synuclein
type: ProteinReference
xref: uniprot P61145 405
xref: PTHR13820:SF5
organism: Pan troglodytes

uniprot O70589 843
type: UnificationXref
id: O70589
db: uniprot

14-3-3 protein beta/alpha
type: ProteinReference
xref: PTHR18860:SF28
xref: uniprot Q5XGC8 1057
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot F7EFF6 996
organism: Macaca mulatta

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot H2QTL3 784
xref: PTHR24418:SF419
organism: Pan troglodytes

GO GO:0005622 4
type: UnificationXref
id: GO:0005622
db: GO

uniprot Q4Q8E6 201
type: UnificationXref
id: Q4Q8E6
db: uniprot

uniprot Q63538 441
type: UnificationXref
id: Q63538
db: uniprot

uniprot Q5ZM98 210
type: UnificationXref
id: Q5ZM98
db: uniprot

uniprot H2R5C6 589
type: UnificationXref
id: H2R5C6
db: uniprot

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 183

Syntaxin-7
type: ProteinReference
xref: uniprot F7ATP9 370
xref: PTHR19957:SF90
organism: Macaca mulatta

uniprot B7Q5I4 970
type: UnificationXref
id: B7Q5I4
db: uniprot

uniprot A0A2I3RZ31 412
type: UnificationXref
id: A0A2I3RZ31
db: uniprot

Casein kinase I isoform delta
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot Q9DC28 1189
organism: Mus musculus

alpha Synuclein s4 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

Casein kinase I homolog hhp1
type: ProteinReference
xref: uniprot P40235 1149
xref: PTHR11909:SF18
organism: Schizosaccharomyces pombe

CSNK2A2 isoform 1
type: ProteinReference
xref: uniprot K7CVS9 895
xref: PTHR24054:SF34
organism: Pan troglodytes

Casein kinase I homolog 2
type: ProteinReference
xref: uniprot P40234 1148
xref: PTHR11909:SF155
organism: Schizosaccharomyces pombe

uniprot Q62761 1165
type: UnificationXref
id: Q62761
db: uniprot

Casein kinase I homolog hhp2
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot P40236 1150
organism: Schizosaccharomyces pombe

Septin-1
type: ProteinReference
xref: uniprot P42209 515
organism: Mus musculus

Parkin
type: Protein
entity reference: Parkin
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa10 1218
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Septin-1
type: ProteinReference
xref: uniprot P42207 513
organism: Drosophila melanogaster

Septin-2
type: ProteinReference
xref: uniprot P42208 514
organism: Mus musculus

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 43

S129 alpha Synuclein s41 a58 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S129
feature location: S129 alpha Synuclein s41 a58 rs1 S129
comment: MODIFICATION_RESIDUE_NAME=S129
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

Casein kinase II subunit beta
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot P40232 916
organism: Schizosaccharomyces pombe

F-box and WD repeat domain containing 11
type: ProteinReference
xref: uniprot A0A2I3SMC0 1096
organism: Pan troglodytes

uniprot J9P6N4 1005
type: UnificationXref
id: J9P6N4
db: uniprot

uniprot P63103 1033
type: UnificationXref
id: P63103
db: uniprot

Casein kinase I homolog 1
type: ProteinReference
xref: uniprot P40233 1147
xref: PTHR11909:SF155
organism: Schizosaccharomyces pombe

Casein kinase II subunit alpha
type: ProteinReference
xref: PTHR24054:SF0
xref: uniprot P40231 915
organism: Schizosaccharomyces pombe

Uncharacterized protein
type: ProteinReference
xref: PTHR10760:SF4
xref: uniprot F7GTV9 452
organism: Macaca mulatta

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r1
control type: INHIBITION
controller: DA

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot F6XAZ1 565
xref: PTHR11599:SF12
organism: Ornithorhynchus anatinus

SFN isoform 1
type: ProteinReference
xref: uniprot H2RC87 1004
xref: PTHR18860:SF14
organism: Pan troglodytes

F-box/WD repeat-containing protein 11
type: ProteinReference
xref: uniprot Q5SRY7 1103
organism: Mus musculus

uniprot O15400 378
type: UnificationXref
id: O15400
db: uniprot

STX7 isoform 4
type: ProteinReference
xref: PTHR19957:SF90
xref: uniprot H2QTR3 376
organism: Pan troglodytes

uniprot V5IKE7 334
type: UnificationXref
id: V5IKE7
db: uniprot

Similar to 14-3-3 protein sigma
type: ProteinReference
xref: PTHR18860:SF14
xref: uniprot Q5EBB0 1051
organism: Rattus norvegicus

Casein kinase 1 isoform 2
type: ProteinReference
xref: uniprot Q9NHE1 1195
xref: PTHR11909:SF18
organism: Leishmania major

Casein kinase 1 isoform 1
type: ProteinReference
xref: uniprot Q9NHE2 1196
xref: PTHR11909:SF18
organism: Leishmania major

uniprot P38646 161
type: UnificationXref
id: P38646
db: uniprot

Cullin-1
type: ProteinReference
xref: uniprot O60999 1087
xref: PTHR11932:SF156
organism: Dictyostelium discoideum

Mitogen-activated protein kinase mpk-1
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot P39745 295
organism: Caenorhabditis elegans

Casein kinase II subunit beta-2
type: ProteinReference
xref: PTHR11740:SF21
xref: uniprot P40229 914
organism: Arabidopsis thaliana

Casein kinase II subunit beta-1
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot P40228 913
organism: Arabidopsis thaliana

Heat shock protein 70 putative
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot C4M3S5 64
organism: Entamoeba histolytica

Putative 14-3-3 family protein BMH1
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot A0A0D1E7J2 963
organism: Ustilago maydis

uniprot P32865 863
type: UnificationXref
id: P32865
db: uniprot

Pristionchus pacificus
type: BioSource
xref: ncbitaxon 54126 102

Major heat shock 70 kDa protein Bbb
type: ProteinReference
xref: uniprot Q9VG58 252
xref: PTHR19375:SF371
organism: Drosophila melanogaster

Proteasome subunit beta
type: ProteinReference
xref: uniprot H2QU28 586
xref: PTHR11599:SF59
organism: Pan troglodytes

E3 ubiquitin-protein ligase parkin
type: ProteinReference
xref: uniprot F6U1L3 390
xref: PTHR11685:SF212
organism: Macaca mulatta

14-3-3 protein beta/alpha
type: ProteinReference
xref: PTHR18860:SF28
xref: uniprot Q9CQV8 1074
organism: Mus musculus

uniprot Q922K9 825
type: UnificationXref
id: Q922K9
db: uniprot

uniprot P97813 17
type: UnificationXref
id: P97813
db: uniprot

Mitochondrial-type HSP70, putative
type: ProteinReference
xref: uniprot A2DCR4 25
xref: PTHR19375:SF184
organism: Trichomonas vaginalis

uniprot F6WV79 422
type: UnificationXref
id: F6WV79
db: uniprot

Septin-4
type: ProteinReference
xref: uniprot P28661 512
organism: Mus musculus

uniprot A8XFD7 368
type: UnificationXref
id: A8XFD7
db: uniprot

Casein kinase II subunit alpha'
type: ProteinReference
xref: uniprot P19784 909
xref: PTHR24054:SF34
organism: Homo sapiens

Casein kinase-like protein
type: ProteinReference
xref: uniprot Q9LID3 1192
xref: PTHR11909:SF391
organism: Arabidopsis thaliana

Complex (CASK/Parkin)
type: Complex
component stoichiometry: Parkin s85 sa23 STOICHIOMETRY ID COMPLEX
component stoichiometry: CASK s79 sa22 STOICHIOMETRY ID COMPLEX
component: Parkin
component: CASK
feature: COMPLEX BINDING FEATURE s103 a129 1203
feature: COMPLEX BINDING FEATURE s103 a129 1205
cellular location: intracellular

Proteasome subunit alpha type-1
type: ProteinReference
xref: uniprot P12881 614
xref: PTHR11599:SF12
organism: Drosophila melanogaster

G protein-coupled receptor kinase 1
type: ProteinReference
xref: uniprot P32865 863
xref: PTHR24355:SF18
organism: Drosophila melanogaster

uniprot P23977 737
type: UnificationXref
id: P23977
db: uniprot

PTHR24054:SF47
type: RelationshipXref
id: PTHR24054:SF47
db: PANTHER Family
relationship type: By Homology

uniprot Q62763 1167
type: UnificationXref
id: Q62763
db: uniprot

PTHR24054:SF46
type: RelationshipXref
id: PTHR24054:SF46
db: PANTHER Family
relationship type: By Homology

Cullin-1
type: ProteinReference
xref: PTHR11932:SF81
xref: uniprot O13790 1086
organism: Schizosaccharomyces pombe

uniprot P21146 859
type: UnificationXref
id: P21146
db: uniprot

PTHR24055:SF222
type: RelationshipXref
id: PTHR24055:SF222
db: PANTHER Family
relationship type: By Homology

Casein kinase 2 alpha 2
type: ProteinReference
xref: PTHR24054:SF34
xref: uniprot F7F9Q9 893
organism: Ornithorhynchus anatinus

PTHR24054:SF43
type: RelationshipXref
id: PTHR24054:SF43
db: PANTHER Family
relationship type: By Homology

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 1054

PTHR24418:SF373
type: RelationshipXref
id: PTHR24418:SF373
db: PANTHER Family
relationship type: By Homology

SYntaXin
type: ProteinReference
xref: uniprot O62236 380
organism: Caenorhabditis elegans

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot Q99170 238
organism: Yarrowia lipolytica

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot C8V7D1 271
organism: Emericella nidulans

uniprot Q6DRF3 684
type: UnificationXref
id: Q6DRF3
db: uniprot

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 143

PTHR24054:SF0
type: RelationshipXref
id: PTHR24054:SF0
db: PANTHER Family
relationship type: By Homology

uniprot P25451 627
type: UnificationXref
id: P25451
db: uniprot

uniprot P61443 169
type: UnificationXref
id: P61443
db: uniprot

Protein CBR-HSP-1
type: ProteinReference
xref: PTHR19375:SF457
xref: uniprot A8WN50 45
organism: Caenorhabditis briggsae

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot F6S8L5 769
organism: Xenopus tropicalis

14-3-3 protein eta
type: ProteinReference
xref: PTHR18860:SF16
xref: uniprot P68511 1039
organism: Rattus norvegicus

Major heat shock 70 kDa protein Ba
type: ProteinReference
xref: uniprot Q8INI8 229
xref: PTHR19375:SF371
organism: Drosophila melanogaster

uniprot Q39021 302
type: UnificationXref
id: Q39021
db: uniprot

uniprot O02812 338
type: UnificationXref
id: O02812
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 880

PTHR18860:SF95
type: RelationshipXref
id: PTHR18860:SF95
db: PANTHER Family
relationship type: By Homology

14-3-3 protein eta
type: ProteinReference
xref: PTHR18860:SF16
xref: uniprot P68510 1038
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r44
controller: GRK

Chaperone protein dnaK2
type: ProteinReference
xref: uniprot P22358 149
xref: PTHR19375:SF184
organism: Synechocystis

uniprot F7FBS3 576
type: UnificationXref
id: F7FBS3
db: uniprot

Casein kinase 1 epsilon
type: ProteinReference
xref: uniprot A0A2I3RHK0 1114
xref: PTHR11909:SF18
organism: Pan troglodytes

uniprot F6VCI6 891
type: UnificationXref
id: F6VCI6
db: uniprot

uniprot Q8W4J2 321
type: UnificationXref
id: Q8W4J2
db: uniprot

uniprot Q9LV37 329
type: UnificationXref
id: Q9LV37
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__CDCrel_1_Parkin_-RIGHT__Complex__CDCrel_1_Parkin_-_r69
controller: UbcH8

PTHR24054:SF28
type: RelationshipXref
id: PTHR24054:SF28
db: PANTHER Family
relationship type: By Homology

PTHR24054:SF27
type: RelationshipXref
id: PTHR24054:SF27
db: PANTHER Family
relationship type: By Homology

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

Beta-synuclein
type: ProteinReference
xref: uniprot F7H5X2 396
xref: PTHR13820:SF4
organism: Macaca mulatta

Parkin s122 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

AT26486p
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot Q9VYN5 1200
organism: Drosophila melanogaster

uniprot P94317 177
type: UnificationXref
id: P94317
db: uniprot

uniprot H2RF71 100
type: UnificationXref
id: H2RF71
db: uniprot

14-3-3
type: ProteinReference
xref: P01238
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: 14-3-3 Synonym: Synonym not specified Accession: P01238
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.14-3-3
member entity reference: 14-3-3 protein epsilon
member entity reference: 14-3-3 protein eta
member entity reference: SFN isoform 1
member entity reference: 14-3-3-like protein
member entity reference: Uncharacterized protein
member entity reference: 14-3-3-like protein GF14 mu
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
member entity reference: 14-3-3-like protein GF14 omicron
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2
member entity reference: 14-3-3 protein theta
member entity reference: 14-3-3-like protein GF14-E
member entity reference: ARTA
member entity reference: 14-3-3 protein 3
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
member entity reference: 14-3-3 protein beta/alpha
member entity reference: Multifunctional chaperone, putative
member entity reference: Protein BMH1
member entity reference: 14-3-3 protein sigma
member entity reference: 14-3-3 protein beta/alpha-A
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
member entity reference: AGAP007643-PA
member entity reference: 14-3-3 protein zeta/delta
member entity reference: 14-3-3-like protein GF14-C
member entity reference: 14-3-3-like protein GF14-D
member entity reference: 14-3-3 protein, putative
member entity reference: DNA damage checkpoint protein rad25
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
member entity reference: 14-3-3 family protein 7
member entity reference: Putative 14-3-3 family protein BMH1
member entity reference: 14-3-3-like protein GF14-B
member entity reference: 14-3-3 protein zeta
member entity reference: 14-3-3-like protein GF14 psi
member entity reference: 14-3-3-like protein GF14 upsilon
member entity reference: Similar to 14-3-3 protein sigma
member entity reference: 14-3-3 protein gamma
member entity reference: 14-3-3-like protein GF14 kappa
member entity reference: 14-3-3-like protein 2
member entity reference: 14-3-3 protein gamma-1
member entity reference: AGR107Cp
member entity reference: 14-3-3 zeta
member entity reference: 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
member entity reference: Stratifin
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
member entity reference: 14-3-3-like protein GF14 lambda
member entity reference: 14-3-3 protein homolog

Synphilin s34 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Synphilin
stoichiometric coefficient: 1.0

uniprot H2PYQ3 97
type: UnificationXref
id: H2PYQ3
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot Q9M1Z5 330
organism: Arabidopsis thaliana

Beta-adrenergic receptor kinase 1
type: ProteinReference
xref: PTHR24355:SF22
xref: uniprot P25098 860
organism: Homo sapiens

PTHR24054:SF34
type: RelationshipXref
id: PTHR24054:SF34
db: PANTHER Family
relationship type: By Homology

PTHR24054:SF35
type: RelationshipXref
id: PTHR24054:SF35
db: PANTHER Family
relationship type: By Homology

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 591

Complex (CDCrel-1/Parkin)
type: Complex
component stoichiometry: CDCrel 1 s107 sa38 STOICHIOMETRY ID COMPLEX
component stoichiometry: Parkin s111 sa39 STOICHIOMETRY ID COMPLEX
component: CDCrel-1
component: Parkin
feature: COMPLEX BINDING FEATURE s119 a173 1253
feature: COMPLEX BINDING FEATURE s119 a173 1255
cellular location: intracellular

uniprot Q5SN53 311
type: UnificationXref
id: Q5SN53
db: uniprot

Transcription factor Elk; Uncharacterized protein
type: ProteinReference
xref: uniprot Q95UJ1 850
xref: PTHR11849:SF133
organism: Strongylocentrotus purpuratus

Complex (DAT/O C342)
type: Complex
component stoichiometry: O C342 s131 sa47 STOICHIOMETRY ID COMPLEX
component stoichiometry: DAT s130 sa46 STOICHIOMETRY ID COMPLEX
component: O C342
component: DAT
feature: COMPLEX BINDING FEATURE s126 a183 1283
feature: COMPLEX BINDING FEATURE s126 a183 1281
cellular location: intracellular

uniprot F7DGH9 994
type: UnificationXref
id: F7DGH9
db: uniprot

Casein kinase 1, epsilon
type: ProteinReference
xref: uniprot Q99PS2 1187
xref: PTHR11909:SF18
organism: Rattus norvegicus

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r1
control type: INHIBITION
controller: Torsin A

PARTICIPANT STOICHIOMETRY r56 1371
type: Stoichiometry
physical entity: Complex (O-glyc/alpha-Synuclein/ Parkin)
stoichiometric coefficient: 1.0

uniprot A8X1S0 417
type: UnificationXref
id: A8X1S0
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__Complex__N_Y125_alpha_Synuclein_-_r53
controller: MPP+

uniprot F6VWY6 6
type: UnificationXref
id: F6VWY6
db: uniprot

uniprot O81275 901
type: UnificationXref
id: O81275
db: uniprot

PARTICIPANT STOICHIOMETRY r56 1370
type: Stoichiometry
physical entity: Ub
stoichiometric coefficient: 1.0

PTHR18860:SF67
type: RelationshipXref
id: PTHR18860:SF67
db: PANTHER Family
relationship type: By Homology

PTHR18860:SF69
type: RelationshipXref
id: PTHR18860:SF69
db: PANTHER Family
relationship type: By Homology

TRANSLATION_LEFT__DAT-RIGHT__DAT-_r74
type: TemplateReaction
product: DAT
xref: TRANSLATION
participant: DAT
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

uniprot A9UMS1 347
type: UnificationXref
id: A9UMS1
db: uniprot

uniprot E9HGM4 1123
type: UnificationXref
id: E9HGM4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot H2RBN7 945
xref: PTHR10371:SF3
organism: Pan troglodytes

uniprot F0ZVR4 69
type: UnificationXref
id: F0ZVR4
db: uniprot

Synphilin s28 a49 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Gamma-synuclein
type: ProteinReference
xref: uniprot Q9NZ50 833
organism: Bos taurus

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF12
xref: uniprot F7FBS3 576
organism: Monodelphis domestica

TRANSCRIPTION_LEFT__DAT-RIGHT__DAT-_re48
type: TemplateReaction
product: DAT
xref: TRANSCRIPTION
participant: DAT
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot Q5XGI6 1164
type: UnificationXref
id: Q5XGI6
db: uniprot

ncbitaxon 208964 244
type: UnificationXref
id: 208964
db: ncbitaxon

uniprot Q9XXG5 462
type: UnificationXref
id: Q9XXG5
db: uniprot

Torsin-1A
type: ProteinReference
xref: uniprot Q68G38 458
xref: PTHR10760:SF15
organism: Rattus norvegicus

uniprot P41969 849
type: UnificationXref
id: P41969
db: uniprot

Septin-1
type: ProteinReference
xref: uniprot Q5EB96 520
organism: Rattus norvegicus

uniprot F6R3X6 503
type: UnificationXref
id: F6R3X6
db: uniprot

Ribosome-associated molecular chaperone sks2
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot Q10284 185
organism: Schizosaccharomyces pombe

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot A0JNB0 756
organism: Bos taurus

CDCrel 1 s128 sa44 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot P39688 804
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r36 1341
type: Stoichiometry
physical entity: SAPK
stoichiometric coefficient: 1.0

Fe-hydrogenase, subunit gamma
type: ProteinReference
xref: uniprot Q9S5X7 958
organism: Thermotoga maritima

uniprot P00528 788
type: UnificationXref
id: P00528
db: uniprot

PARTICIPANT STOICHIOMETRY r36 1342
type: Stoichiometry
physical entity: SAPK
stoichiometric coefficient: 1.0

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot E2RMN2 548
organism: Canis lupus familiaris

PTHR18860:SF83
type: RelationshipXref
id: PTHR18860:SF83
db: PANTHER Family
relationship type: By Homology

uniprot P38930 912
type: UnificationXref
id: P38930
db: uniprot

uniprot F7DY42 995
type: UnificationXref
id: F7DY42
db: uniprot

uniprot F6YUL8 505
type: UnificationXref
id: F6YUL8
db: uniprot

uniprot O70257 381
type: UnificationXref
id: O70257
db: uniprot

uniprot Q7PPI7 695
type: UnificationXref
id: Q7PPI7
db: uniprot

uniprot Q8TG12 938
type: UnificationXref
id: Q8TG12
db: uniprot

TRANSPORT_LEFT__MPP_PLUS_-RIGHT__MPP_PLUS_-_r3
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 1303
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 1304
left: MPP+
interaction type: TRANSPORT
right: MPP+

uniprot Q8WQG9 442
type: UnificationXref
id: Q8WQG9
db: uniprot

PTHR24055:SF238
type: RelationshipXref
id: PTHR24055:SF238
db: PANTHER Family
relationship type: By Homology

PTHR18860:SF72
type: RelationshipXref
id: PTHR18860:SF72
db: PANTHER Family
relationship type: By Homology

Prosaposin receptor GPR37
type: ProteinReference
xref: uniprot Q9QYC6 749
xref: PTHR46216:SF3
organism: Rattus norvegicus

uniprot F6T584 1082
type: UnificationXref
id: F6T584
db: uniprot

Probable heat shock protein ssa1
type: ProteinReference
xref: PTHR19375:SF426
xref: uniprot Q10265 184
organism: Schizosaccharomyces pombe

3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot E7F354 977
organism: Danio rerio

G-protein coupled receptor 37-like 1
type: ProteinReference
xref: uniprot Q9QYC5 748
organism: Rattus norvegicus

GRK
type: Protein
entity reference: GRK
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q6EWH2 820
type: UnificationXref
id: Q6EWH2
db: uniprot

beta-Synuclein
type: ProteinReference
xref: P01217
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: beta-Synuclein Synonym: Synonym not specified Accession: P01217
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC._beta_-Synuclein
member entity reference: Beta-synuclein

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot E1BIM8 759
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r56 1369
type: Stoichiometry
physical entity: Complex (O-glyc/alpha-Synuclein/ Parkin)
stoichiometric coefficient: 1.0

Prosaposin receptor GPR37
type: ProteinReference
xref: uniprot O15354 744
xref: PTHR46216:SF3
organism: Homo sapiens

PTHR18860:SF21
type: RelationshipXref
id: PTHR18860:SF21
db: PANTHER Family
relationship type: By Homology

PTHR18860:SF22
type: RelationshipXref
id: PTHR18860:SF22
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF3
xref: uniprot F7A0H3 991
organism: Ornithorhynchus anatinus

Casein kinase II subunit beta
type: ProteinReference
xref: uniprot P67870 919
xref: PTHR11740:SF0
organism: Homo sapiens

Casein kinase II subunit beta
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot P67871 920
organism: Mus musculus

Casein kinase II subunit beta
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot P67874 921
organism: Rattus norvegicus

Parkin s33 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

Tyrosine-protein kinase fyna
type: ProteinReference
xref: uniprot Q6EWH2 820
xref: PTHR24418:SF44
organism: Danio rerio

Casein kinase II subunit beta
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot P67868 918
organism: Bos taurus

uniprot F6QKL0 75
type: UnificationXref
id: F6QKL0
db: uniprot

uniprot Q9Y6H5 495
type: UnificationXref
id: Q9Y6H5
db: uniprot

Synphilin
type: Protein
entity reference: Synphilin
feature: Synphilin s30 sa9 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa9 1216
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PTHR18860:SF28
type: RelationshipXref
id: PTHR18860:SF28
db: PANTHER Family
relationship type: By Homology

Proteasome subunit alpha type
type: ProteinReference
xref: uniprot E2RF52 546
xref: PTHR11599:SF144
organism: Canis lupus familiaris

uniprot P22953 152
type: UnificationXref
id: P22953
db: uniprot

PTHR18860:SF16
type: RelationshipXref
id: PTHR18860:SF16
db: PANTHER Family
relationship type: By Homology

PTHR18860:SF14
type: RelationshipXref
id: PTHR18860:SF14
db: PANTHER Family
relationship type: By Homology

Phospholipase
type: ProteinReference
xref: uniprot F6VWY6 6
xref: PTHR18896:SF121
organism: Macaca mulatta

p38 MAPK s73 a100 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Parkin
type: Protein
entity reference: Parkin
feature: COMPLEX PARTICIPANT BINDING FEATURE s93 sa28 1228
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F7EFF6 996
type: UnificationXref
id: F7EFF6
db: uniprot

uniprot F1MYD0 1080
type: UnificationXref
id: F1MYD0
db: uniprot

Prosaposin receptor GPR37
type: ProteinReference
xref: PTHR46216:SF3
xref: uniprot Q9QY42 747
organism: Mus musculus

PTHR18860:SF17
type: RelationshipXref
id: PTHR18860:SF17
db: PANTHER Family
relationship type: By Homology

uniprot A0A2J8J5X6 394
type: UnificationXref
id: A0A2J8J5X6
db: uniprot

Mitogen-activated protein kinase (Fragment)
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot Q7PVR1 316
organism: Anopheles gambiae

uniprot P68255 1037
type: UnificationXref
id: P68255
db: uniprot

Proteasome subunit beta
type: ProteinReference
xref: uniprot D3YUM8 539
xref: PTHR11599:SF62
organism: Mus musculus

PTHR24067:SF154
type: RelationshipXref
id: PTHR24067:SF154
db: PANTHER Family
relationship type: By Homology

ncbitaxon 237631 264
type: UnificationXref
id: 237631
db: ncbitaxon

uniprot E2RPC6 549
type: UnificationXref
id: E2RPC6
db: uniprot

PTHR11909:SF297
type: RelationshipXref
id: PTHR11909:SF297
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase Lck
type: ProteinReference
xref: PTHR24418:SF39
xref: uniprot P06239 790
organism: Homo sapiens

uniprot G2HEC7 1085
type: UnificationXref
id: G2HEC7
db: uniprot

uniprot F7AM42 1130
type: UnificationXref
id: F7AM42
db: uniprot

uniprot A0NGZ6 837
type: UnificationXref
id: A0NGZ6
db: uniprot

uniprot O14818 595
type: UnificationXref
id: O14818
db: uniprot

PTHR18860:SF31
type: RelationshipXref
id: PTHR18860:SF31
db: PANTHER Family
relationship type: By Homology

19S proteasome
type: Protein
entity reference: 19S proteasome
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa3 1212
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 884

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot P06241 792
organism: Homo sapiens

Proto-oncogene tyrosine-protein kinase LCK
type: ProteinReference
xref: uniprot P06240 791
xref: PTHR24418:SF39
organism: Mus musculus

14-3-3 protein zeta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot Q6P4Z5 1064
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot F1PBL1 980
xref: PTHR18860:SF7
organism: Canis lupus familiaris

uniprot P25789 631
type: UnificationXref
id: P25789
db: uniprot

gamma-Synuclein
type: Protein
entity reference: gamma-Synuclein
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F6QQC0 768
xref: PTHR24418:SF181
organism: Macaca mulatta

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot F6PKK7 767
organism: Macaca mulatta

Casein kinase II
type: ProteinReference
xref: PTHR24054:SF0
xref: uniprot A7F2U3 870
organism: Sclerotinia sclerotiorum

uniprot A8WN50 45
type: UnificationXref
id: A8WN50
db: uniprot

78 kDa glucose-regulated protein
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot F7C3R1 88
organism: Macaca mulatta

uniprot P18421 617
type: UnificationXref
id: P18421
db: uniprot

alpha Synuclein s49 a69 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.528611247526151

Casein kinase I isoform alpha
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot P67827 1156
organism: Bos taurus

uniprot O67118 111
type: UnificationXref
id: O67118
db: uniprot

ncbitaxon 7165 37
type: UnificationXref
id: 7165
db: ncbitaxon

HETERODIMER_ASSOCIATION_LEFT__Syntaxin-_CDCrel_1-RIGHT__Complex__CDCrel_1_Syntaxin_-_r71
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 1329
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 1328
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 1327
left: Syntaxin
left: CDCrel-1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (CDCrel-1/Syntaxin)

uniprot P62260 1029
type: UnificationXref
id: P62260
db: uniprot

CHIP
type: ProteinReference
xref: P01214
standard name: Carboxyl terminus of the Hsc-70 interacting protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.CHIP
comment: ENTITY_REFERENCE_NOTES= Long Name: Carboxyl terminus of the Hsc-70 interacting protein Synonym: Synonym not specified Accession: P01214
member entity reference: STIP1 homology and U-box containing protein 1
member entity reference: Carboxy terminus of Hsp70-interacting protein
member entity reference: STIP1 homology and U-Box containing protein 1, isoform CRA_b
member entity reference: E3 ubiquitin-protein ligase CHIP
member entity reference: C-term of Hsp70-iNteracting protein (CHIP family)
member entity reference: STIP1 homology and U box-containing protein 1

AGAP004944-PA
type: ProteinReference
xref: uniprot Q7Q7Y8 221
xref: PTHR19375:SF457
organism: Anopheles gambiae

uniprot Q7QCI4 521
type: UnificationXref
id: Q7QCI4
db: uniprot

Mitogen-activated protein kinase 18
type: ProteinReference
xref: uniprot Q9C5C0 322
organism: Arabidopsis thaliana

uniprot A8JGV6 967
type: UnificationXref
id: A8JGV6
db: uniprot

uniprot P31946 1011
type: UnificationXref
id: P31946
db: uniprot

uniprot P09435 116
type: UnificationXref
id: P09435
db: uniprot

uniprot Q9WUD1 365
type: UnificationXref
id: Q9WUD1
db: uniprot

Beta-synuclein
type: ProteinReference
xref: uniprot A0A2J8J5X6 394
xref: PTHR13820:SF4
organism: Pan troglodytes

Mitogen-activated protein kinase 15
type: ProteinReference
xref: uniprot Q11179 299
xref: PTHR24055:SF79
organism: Caenorhabditis elegans

uniprot F1R9V3 74
type: UnificationXref
id: F1R9V3
db: uniprot

uniprot Q5BBL8 208
type: UnificationXref
id: Q5BBL8
db: uniprot

Proteasome subunit beta type-2
type: ProteinReference
xref: PTHR11599:SF44
xref: uniprot P25043 626
organism: Saccharomyces cerevisiae

Uncharacterized protein
type: ProteinReference
xref: PTHR11932:SF81
xref: uniprot F6T584 1082
organism: Monodelphis domestica

uniprot Q7DLS1 692
type: UnificationXref
id: Q7DLS1
db: uniprot

14-3-3 protein gamma-1
type: ProteinReference
xref: uniprot Q6PC29 1065
xref: PTHR18860:SF22
organism: Danio rerio

TH
type: Protein
entity reference: TH
feature: COMPLEX PARTICIPANT BINDING FEATURE s100 sa34 1244
feature: TH s100 sa34 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

ncbitaxon 185431 190
type: UnificationXref
id: 185431
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR10177:SF70
xref: uniprot F6Q7B1 350
organism: Macaca mulatta

uniprot P52487 476
type: UnificationXref
id: P52487
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF16
xref: uniprot F6WA79 986
organism: Monodelphis domestica

Cullin 1b
type: ProteinReference
xref: uniprot F1Q7M5 1081
xref: PTHR11932:SF81
organism: Danio rerio

alpha Synuclein s49 a69 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot Q943K7 237
type: UnificationXref
id: Q943K7
db: uniprot

uniprot A0A2I3RNK5 1116
type: UnificationXref
id: A0A2I3RNK5
db: uniprot

uniprot F6U1L3 390
type: UnificationXref
id: F6U1L3
db: uniprot

UBE2L6 isoform 2
type: ProteinReference
xref: PTHR24068:SF43
xref: uniprot H2Q3P2 474
organism: Pan troglodytes

uniprot O96020 353
type: UnificationXref
id: O96020
db: uniprot

uniprot F7C4Y9 467
type: UnificationXref
id: F7C4Y9
db: uniprot

uniprot P21670 622
type: UnificationXref
id: P21670
db: uniprot

uniprot O15354 744
type: UnificationXref
id: O15354
db: uniprot

Casein kinase II subunit beta'
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot P38930 912
organism: Saccharomyces cerevisiae

PTHR18884:SF68
type: RelationshipXref
id: PTHR18884:SF68
db: PANTHER Family
relationship type: By Homology

Proteasome subunit beta
type: ProteinReference
xref: PTHR11599:SF5
xref: uniprot D6XEX9 542
organism: Trypanosoma brucei

Protein CBG13234
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot A8XHD1 48
organism: Caenorhabditis briggsae

uniprot A2EY23 34
type: UnificationXref
id: A2EY23
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZBE3 879
xref: PTHR24054:SF0
organism: Branchiostoma floridae

CASK isoform 4
type: ProteinReference
xref: uniprot H2R4R8 841
xref: PTHR23122:SF40
organism: Pan troglodytes

Tyrosine 3-monooxygenase
type: ProteinReference
xref: uniprot P04177 1109
xref: PTHR11473:SF18
organism: Rattus norvegicus

TH s97 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TH
stoichiometric coefficient: 1.0

uniprot A0A1D5QVF6 835
type: UnificationXref
id: A0A1D5QVF6
db: uniprot

ncbitaxon 9544 7
type: UnificationXref
id: 9544
db: ncbitaxon

Elk 1 s53 a77 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR11909:SF323
type: RelationshipXref
id: PTHR11909:SF323
db: PANTHER Family
relationship type: By Homology

uniprot P49720 645
type: UnificationXref
id: P49720
db: uniprot

PTHR11909:SF329
type: RelationshipXref
id: PTHR11909:SF329
db: PANTHER Family
relationship type: By Homology

Proteasome subunit beta type-7-B
type: ProteinReference
xref: uniprot Q7DLS1 692
xref: PTHR11599:SF44
organism: Arabidopsis thaliana

Beta-synuclein
type: ProteinReference
xref: uniprot E2R6G0 395
xref: PTHR13820:SF4
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H4H9 998
xref: PTHR18860:SF3
organism: Macaca mulatta

uniprot P22769 623
type: UnificationXref
id: P22769
db: uniprot

Pael-R
type: Protein
entity reference: Pael-R
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa14 1272
feature: Pael R s38 sa14 rs1
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot P41241 806
type: UnificationXref
id: P41241
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
type: ProteinReference
xref: PTHR18860:SF28
xref: uniprot F1PKW7 981
organism: Canis lupus familiaris

uniprot P48730 1153
type: UnificationXref
id: P48730
db: uniprot

eco ECO:0000304 256
type: UnificationXref
id: ECO:0000304
db: eco

Proteasome subunit alpha type-7-B
type: ProteinReference
xref: PTHR11599:SF114
xref: uniprot Q0J006 653
organism: Oryza sativa

uniprot Q6DGX8 683
type: UnificationXref
id: Q6DGX8
db: uniprot

14-3-3 protein sigma
type: ProteinReference
xref: PTHR18860:SF14
xref: uniprot G7MHX1 1000
organism: Macaca mulatta

uniprot F6QW93 560
type: UnificationXref
id: F6QW93
db: uniprot

uniprot P28661 512
type: UnificationXref
id: P28661
db: uniprot

uniprot P00523 787
type: UnificationXref
id: P00523
db: uniprot

uniprot P68254 1036
type: UnificationXref
id: P68254
db: uniprot

PTHR11909:SF316
type: RelationshipXref
id: PTHR11909:SF316
db: PANTHER Family
relationship type: By Homology

uniprot F7G374 779
type: UnificationXref
id: F7G374
db: uniprot

Syntaxin-12
type: ProteinReference
xref: PTHR19957:SF88
xref: uniprot Q9ER00 388
organism: Mus musculus

Protein CBR-LIN-2
type: ProteinReference
xref: PTHR23122:SF7
xref: uniprot A8WMC8 838
organism: Caenorhabditis briggsae

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot Q4VBR8 677
organism: Danio rerio

uniprot C4M323 974
type: UnificationXref
id: C4M323
db: uniprot

20S proteasome
type: Protein
entity reference: 20S proteasome
feature: ACTIVE 21
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa2 1280
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 226

Proteasome subunit beta type-4
type: ProteinReference
xref: uniprot Q7DLR9 691
xref: PTHR11599:SF5
organism: Arabidopsis thaliana

uniprot Q9LSU3 718
type: UnificationXref
id: Q9LSU3
db: uniprot

Casein kinase I
type: Protein
entity reference: Casein kinase I
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot O81148 608
type: UnificationXref
id: O81148
db: uniprot

GRK
type: ProteinReference
xref: P01234
standard name: G-protein related kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: G-protein related kinase Synonym: Synonym not specified Accession: P01234
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.GRK
member entity reference: Beta-adrenergic receptor kinase 2
member entity reference: Beta-adrenergic receptor kinase 1
member entity reference: G protein-coupled receptor kinase
member entity reference: G protein-coupled receptor kinase 2
member entity reference: G protein-coupled receptor kinase 1

Septin-2B
type: ProteinReference
xref: uniprot A1L0Y5 499
organism: Xenopus tropicalis

uniprot Q9VXE8 448
type: UnificationXref
id: Q9VXE8
db: uniprot

synaptic vesicle
type: CellularLocationVocabulary
xref: GO GO:0008021 2

20S proteasome
type: ProteinReference
xref: P01227
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: 20S proteasome Synonym: Synonym not specified Accession: P01227
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.20S proteasome
member entity reference: Proteasome subunit beta
member entity reference: Proteasome subunit alpha type
member entity reference: Proteasome subunit alpha type-7-1A
member entity reference: Proteasome subunit alpha type-1
member entity reference: Probable proteasome subunit alpha type-2
member entity reference: Proteasome subunit alpha type-3
member entity reference: Proteasome subunit beta type-4
member entity reference: Proteasome subunit alpha type-6
member entity reference: Probable proteasome subunit beta type-2
member entity reference: Proteasome subunit alpha type (Fragment)
member entity reference: Proteasome subunit alpha type-4
member entity reference: Proteasome endopeptidase complex
member entity reference: Proteasome subunit alpha type-2
member entity reference: Proteasome subunit alpha type-4-2
member entity reference: Proteasome subunit beta type-2
member entity reference: Proteasome subunit beta type-1
member entity reference: Proteasome subunit alpha type-2-B
member entity reference: Proteasome subunit alpha type-4-like
member entity reference: Proteasome subunit alpha type-7
member entity reference: Proteasome subunit beta type-7-A
member entity reference: Proteasome subunit beta type-3
member entity reference: Proteasome subunit alpha-type 7-like
member entity reference: Uncharacterized protein
member entity reference: Proteasome subunit alpha type-6-B
member entity reference: Proteasome subunit beta type-7
member entity reference: Proteasome subunit alpha type-4-1
member entity reference: Proteasome subunit alpha type-7-1B

Proteasome subunit beta
type: ProteinReference
xref: uniprot Q6DRF3 684
xref: PTHR11599:SF59
organism: Danio rerio

PTHR24418:SF407
type: RelationshipXref
id: PTHR24418:SF407
db: PANTHER Family
relationship type: By Homology

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot Q5CZQ1 1050
organism: Danio rerio

PLD2
type: Protein
entity reference: PLD2
feature: ACTIVE 21
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F6ZC17 485
type: UnificationXref
id: F6ZC17
db: uniprot

uniprot A2E1L2 28
type: UnificationXref
id: A2E1L2
db: uniprot

Proteasome subunit beta
type: ProteinReference
xref: uniprot E1BYW9 544
xref: PTHR11599:SF62
organism: Gallus gallus

uniprot P17821 142
type: UnificationXref
id: P17821
db: uniprot

Proto-oncogene tyrosine-protein kinase LCK
type: ProteinReference
xref: uniprot Q01621 810
xref: PTHR24418:SF39
organism: Rattus norvegicus

uniprot E2R5J6 853
type: UnificationXref
id: E2R5J6
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9LQQ9 327
xref: PTHR24055:SF438
organism: Arabidopsis thaliana

Proteasome subunit alpha type-3
type: ProteinReference
xref: PTHR11599:SF10
xref: uniprot Q58DU5 679
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38_MAPK-RIGHT__p38_MAPK-_r47
controller: alpha-Synuclein

Carboxy terminus of Hsp70-interacting protein
type: ProteinReference
xref: PTHR46803:SF2
xref: uniprot Q9XYW6 366
organism: Drosophila melanogaster

TH
type: ProteinReference
xref: P01241
standard name: Tyrosine hydroxylase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Tyrosine hydroxylase Synonym: Synonym not specified Accession: P01241
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.TH
member entity reference: Tyrosine 3-monooxygenase
member entity reference: TH isoform 6
member entity reference: Uncharacterized protein

O2
type: SmallMolecule
cellular location: mitochondrion
comment: SPECIES_TYPE=ION

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF15
xref: uniprot Q384W9 665
organism: Trypanosoma brucei

Proteasome subunit alpha type-1
type: ProteinReference
xref: uniprot O42265 602
xref: PTHR11599:SF12
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r54 1378
type: Stoichiometry
physical entity: CASK
stoichiometric coefficient: 1.0

uniprot P28066 632
type: UnificationXref
id: P28066
db: uniprot

PARTICIPANT STOICHIOMETRY r54 1377
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r54 1379
type: Stoichiometry
physical entity: Complex (CASK/Parkin)
stoichiometric coefficient: 1.0

Ubiquitin-conjugating enzyme E2 J2
type: ProteinReference
xref: PTHR24068:SF135
xref: uniprot Q2TA03 468
organism: Bos taurus

PTHR18860:SF115
type: RelationshipXref
id: PTHR18860:SF115
db: PANTHER Family
relationship type: By Homology

PTHR18860:SF112
type: RelationshipXref
id: PTHR18860:SF112
db: PANTHER Family
relationship type: By Homology

ncbitaxon 224911 178
type: UnificationXref
id: 224911
db: ncbitaxon

Ubiquitin carboxyl-terminal hydrolase isozyme L1
type: ProteinReference
xref: uniprot Q9R0P9 262
xref: PTHR10589:SF19
organism: Mus musculus

uniprot H2QUT2 1003
type: UnificationXref
id: H2QUT2
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P49186 434
organism: Rattus norvegicus

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot P49187 435
xref: PTHR24055:SF162
organism: Rattus norvegicus

Casein kinase II alpha subunit
type: ProteinReference
xref: uniprot Q8H386 934
xref: PTHR24054:SF0
organism: Oryza sativa

ncbitaxon 284811 218
type: UnificationXref
id: 284811
db: ncbitaxon

uniprot Q9C9U4 323
type: UnificationXref
id: Q9C9U4
db: uniprot

PTHR18860:SF106
type: RelationshipXref
id: PTHR18860:SF106
db: PANTHER Family
relationship type: By Homology

PTHR18860:SF101
type: RelationshipXref
id: PTHR18860:SF101
db: PANTHER Family
relationship type: By Homology

PTHR18860:SF103
type: RelationshipXref
id: PTHR18860:SF103
db: PANTHER Family
relationship type: By Homology

G1/S-specific cyclin-E1
type: ProteinReference
xref: uniprot P47794 356
xref: PTHR10177:SF71
organism: Danio rerio

Heat shock 70 kDa protein, mitochondrial, putative
type: ProteinReference
xref: PTHR19375:SF184
xref: uniprot Q585X3 206
organism: Trypanosoma brucei

PTHR18860:SF109
type: RelationshipXref
id: PTHR18860:SF109
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR11473:SF18
xref: uniprot A0A1D5RJP1 1107
organism: Macaca mulatta

Protein kinase superfamily protein
type: ProteinReference
xref: PTHR11909:SF356
xref: uniprot F4JID0 1125
organism: Arabidopsis thaliana

ncbitaxon 7955 59
type: UnificationXref
id: 7955
db: ncbitaxon

Casein kinase II subunit beta
type: ProteinReference
xref: PTHR11740:SF0
xref: uniprot A7SG27 871
organism: Nematostella vectensis

Proteasome subunit beta
type: ProteinReference
xref: uniprot Q384T8 664
xref: PTHR11599:SF62
organism: Trypanosoma brucei

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF10
xref: uniprot F6XZS3 567
organism: Xenopus tropicalis

Cytosolic heat shock protein 70, putative
type: ProteinReference
xref: uniprot A2E9W8 30
xref: PTHR19375:SF395
organism: Trichomonas vaginalis

uniprot Q01233 181
type: UnificationXref
id: Q01233
db: uniprot

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF17
xref: uniprot K7B2K4 858
organism: Pan troglodytes

Protein BMH1
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot P29311 1010
organism: Saccharomyces cerevisiae

14-3-3 protein zeta
type: ProteinReference
xref: uniprot P29310 1009
xref: PTHR18860:SF106
organism: Drosophila melanogaster

Bos taurus
type: BioSource
xref: ncbitaxon 9913 20

NADH dehydrogenase (Ubiquinone) 24 kDa subunit, isoform A
type: ProteinReference
xref: PTHR10371:SF3
xref: uniprot Q9VX36 960
organism: Drosophila melanogaster

uniprot Q24178 658
type: UnificationXref
id: Q24178
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FVG8 1101
organism: Macaca mulatta

PTHR18860:SF125
type: RelationshipXref
id: PTHR18860:SF125
db: PANTHER Family
relationship type: By Homology

uniprot J9P9G4 592
type: UnificationXref
id: J9P9G4
db: uniprot

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF22
xref: uniprot H2Q482 857
organism: Pan troglodytes

uniprot F7CT33 736
type: UnificationXref
id: F7CT33
db: uniprot

Proteasome subunit beta
type: ProteinReference
xref: uniprot Q38DP7 669
xref: PTHR11599:SF44
organism: Trypanosoma brucei

NADH dehydrogenase I, E subunit
type: ProteinReference
xref: uniprot Q9RU91 957
xref: PTHR10371:SF3
organism: Deinococcus radiodurans

uniprot O44156 603
type: UnificationXref
id: O44156
db: uniprot

Casein kinase 1-like protein 3
type: ProteinReference
xref: PTHR11909:SF97
xref: uniprot Q93Z18 1185
organism: Arabidopsis thaliana

Uncharacterized protein
type: ProteinReference
xref: PTHR24068:SF135
xref: uniprot E1BZ66 465
organism: Gallus gallus

Heat shock 70 kDa protein 1A
type: ProteinReference
xref: uniprot Q27975 188
xref: PTHR19375:SF223
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r50 1393
type: Stoichiometry
physical entity: a109_degraded
stoichiometric coefficient: 1.0

Proteasome subunit alpha type-7
type: ProteinReference
xref: uniprot P48004 644
xref: PTHR11599:SF40
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r50 1392
type: Stoichiometry
physical entity: Complex (Parkin/Pael-R)
stoichiometric coefficient: 1.0

Heat shock protein
type: ProteinReference
xref: PTHR19375:SF426
xref: uniprot F0ZVR4 69
organism: Dictyostelium purpureum

uniprot A0A1D5RHS9 530
type: UnificationXref
id: A0A1D5RHS9
db: uniprot

Putative syntaxin-24
type: ProteinReference
xref: uniprot Q9C615 387
organism: Arabidopsis thaliana

uniprot E2RSB0 418
type: UnificationXref
id: E2RSB0
db: uniprot

Complex (O-glyc/alpha-Synuclein/ Parkin)
type: Complex
component stoichiometry: O glyc s91 sa26 STOICHIOMETRY ID COMPLEX
component stoichiometry: Parkin s93 sa28 STOICHIOMETRY ID COMPLEX
component stoichiometry: alpha Synuclein s92 sa27 STOICHIOMETRY ID COMPLEX
component: O-glyc
component: Parkin
component: alpha-Synuclein
feature: COMPLEX BINDING FEATURE s106 a141 1227
feature: COMPLEX BINDING FEATURE s106 a141 1225
feature: COMPLEX BINDING FEATURE s106 a141 1223
cellular location: intracellular

uniprot B4F7A9 877
type: UnificationXref
id: B4F7A9
db: uniprot

uniprot Q9Z2U1 735
type: UnificationXref
id: Q9Z2U1
db: uniprot

Ribosome-associated molecular chaperone SSB2
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot P40150 164
organism: Saccharomyces cerevisiae

uniprot P25043 626
type: UnificationXref
id: P25043
db: uniprot

STATE_TRANSITION_LEFT__SAPK-RIGHT__SAPK-_r36
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 1341
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 1342
left: SAPK
interaction type: STATE_TRANSITION
right: SAPK

Casein kinase 2 alpha subunit
type: ProteinReference
xref: uniprot Q8T3S5 936
xref: PTHR24054:SF0
organism: Ciona intestinalis

Heat shock protein family A (Hsp70) member 6
type: ProteinReference
xref: PTHR19375:SF168
xref: uniprot F1MWU9 71
organism: Bos taurus

uniprot A9THD0 876
type: UnificationXref
id: A9THD0
db: uniprot

Extracellular signal-regulated kinase 2
type: ProteinReference
xref: PTHR24055:SF79
xref: uniprot Q54QB1 309
organism: Dictyostelium discoideum

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 23

uniprot P40301 640
type: UnificationXref
id: P40301
db: uniprot

uniprot A8XCT2 943
type: UnificationXref
id: A8XCT2
db: uniprot

Torsin-1A
type: ProteinReference
xref: PTHR10760:SF15
xref: uniprot Q9ER39 461
organism: Mus musculus

Complex (TH/Parkin)
type: Complex
component stoichiometry: TH s100 sa34 STOICHIOMETRY ID COMPLEX
component stoichiometry: Parkin s104 sa35 STOICHIOMETRY ID COMPLEX
component: Parkin
component: TH
feature: COMPLEX BINDING FEATURE s113 a157 1245
feature: COMPLEX BINDING FEATURE s113 a157 1243
cellular location: intracellular

uniprot Q8N752 1180
type: UnificationXref
id: Q8N752
db: uniprot

uniprot Q27563 661
type: UnificationXref
id: Q27563
db: uniprot

uniprot Q4VBR8 677
type: UnificationXref
id: Q4VBR8
db: uniprot

STATE_TRANSITION_LEFT__Cyclin_E-RIGHT__Cyclin_E-_r51
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 1391
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 1390
left: Cyclin E
interaction type: STATE_TRANSITION
right: Cyclin E

L-tyrosine
type: SmallMolecule
cellular location: intracellular
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A2DFX7 27
type: UnificationXref
id: A2DFX7
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__a1_degraded-_r18
controller: Complex (19S proteasome/20S proteasome)

uniprot Q9C5C0 322
type: UnificationXref
id: Q9C5C0
db: uniprot

Ubiquitin-conjugating enzyme E2 J2
type: ProteinReference
xref: uniprot Q8N2K1 471
xref: PTHR24068:SF135
organism: Homo sapiens

14-3-3-like protein GF14-A
type: ProteinReference
xref: uniprot Q84J55 1072
xref: PTHR18860:SF83
organism: Oryza sativa

TH s110 a151 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot K7CEN2 286
xref: PTHR24055:SF356
organism: Pan troglodytes

alpha Synuclein s50 a70 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Heat shock 70 kDa protein 1A
type: ProteinReference
xref: uniprot P0DMW0 125
xref: PTHR19375:SF223
organism: Rattus norvegicus

Heat shock 70 kDa protein 1B
type: ProteinReference
xref: PTHR19375:SF223
xref: uniprot P0DMW1 126
organism: Rattus norvegicus

Heat shock 70 kDa protein 1A
type: ProteinReference
xref: PTHR19375:SF223
xref: uniprot P0DMV8 123
organism: Homo sapiens

Heat shock 70 kDa protein 1B
type: ProteinReference
xref: uniprot P0DMV9 124
xref: PTHR19375:SF223
organism: Homo sapiens

uniprot P33672 634
type: UnificationXref
id: P33672
db: uniprot

uniprot F6PGK6 450
type: UnificationXref
id: F6PGK6
db: uniprot

uniprot K7D8P4 896
type: UnificationXref
id: K7D8P4
db: uniprot

Casein kinase II
type: ProteinReference
xref: P01236
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Casein kinase II Synonym: Synonym not specified Accession: P01236
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.Casein kinase II
member entity reference: Casein kinase II subunit alpha
member entity reference: Casein kinase II subunit alpha-3
member entity reference: CSNK2A1 isoform 3
member entity reference: Predicted protein
member entity reference: Casein kinase II subunit beta
member entity reference: Casein kinase II subunit beta-3
member entity reference: Casein kinase II, alpha chain, putative, expressed
member entity reference: AGAP005569-PA
member entity reference: Casein kinase II subunit beta'
member entity reference: Uncharacterized protein
member entity reference: Putative casein kinase II subunit beta-4
member entity reference: Casein kinase II subunit beta-2
member entity reference: Protein CBR-KIN-3
member entity reference: Casein kinase II subunit alpha'
member entity reference: Casein kinase 2 alpha 2
member entity reference: Casein kinase II alpha subunit
member entity reference: YALI0D16863p
member entity reference: Protein serine/threonine kinase
member entity reference: Probable casein kinase II subunit beta-2
member entity reference: Casein kinase 2 alpha subunit
member entity reference: Casein kinase II subunit alpha 3
member entity reference: Casein kinase 2 beta
member entity reference: Zgc:86598
member entity reference: Casein kinase II
member entity reference: Casein kinase II, putative
member entity reference: Casein kinase II subunit alpha-4, chloroplastic
member entity reference: Casein kinase II subunit beta-1
member entity reference: Casein kinase 2, alpha prime polypeptide a
member entity reference: CSNK2A2 isoform 1
member entity reference: Putative casein kinase II

alpha Synuclein s50 a70 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.528611247526151

uniprot P23639 625
type: UnificationXref
id: P23639
db: uniprot

uniprot P40302 641
type: UnificationXref
id: P40302
db: uniprot

uniprot O59770 604
type: UnificationXref
id: O59770
db: uniprot

Alpha-synuclein
type: ProteinReference
xref: uniprot E2RDD9 401
xref: PTHR13820:SF5
organism: Canis lupus familiaris

uniprot E9H1W5 978
type: UnificationXref
id: E9H1W5
db: uniprot

Parkin s98 sa33 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

uniprot F6V652 82
type: UnificationXref
id: F6V652
db: uniprot

uniprot Q39023 304
type: UnificationXref
id: Q39023
db: uniprot

G-protein coupled receptor 37-like 1
type: ProteinReference
xref: uniprot O60883 745
organism: Homo sapiens

Mitogen-activated protein kinase 15
type: ProteinReference
xref: uniprot Q8TD08 320
xref: PTHR24055:SF79
organism: Homo sapiens

Probable proteasome subunit alpha type-6
type: ProteinReference
xref: uniprot O14250 594
xref: PTHR11599:SF12
organism: Schizosaccharomyces pombe

uniprot F6Z1G9 86
type: UnificationXref
id: F6Z1G9
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__alpha_Synuclein-_19S_proteasome-RIGHT__Complex__19S_proteasome_alpha_Synuclein_-_r22
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 1380
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 1382
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 1381
left: alpha-Synuclein
left: 19S proteasome
interaction type: HETERODIMER_ASSOCIATION
right: Complex (19S proteasome/alpha-Synuclein)

Proteasome subunit beta type-3
type: ProteinReference
xref: PTHR11599:SF62
xref: uniprot P40112 639
organism: Rattus norvegicus

PANTHER Pathway P00049 1
type: UnificationXref
id: P00049
db: PANTHER Pathway

Glucose-regulated protein 78, putative
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot Q384Q5 192
organism: Trypanosoma brucei

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 187

uniprot F6TNW3 984
type: UnificationXref
id: F6TNW3
db: uniprot

uniprot F6X6I5 772
type: UnificationXref
id: F6X6I5
db: uniprot

Septin 4
type: ProteinReference
xref: uniprot H2QDJ4 509
organism: Pan troglodytes

Proteasome subunit beta
type: ProteinReference
xref: PTHR11599:SF44
xref: uniprot O62102 605
organism: Caenorhabditis elegans

uniprot P54632 1023
type: UnificationXref
id: P54632
db: uniprot

uniprot P9WMJ9 179
type: UnificationXref
id: P9WMJ9
db: uniprot

Tyrosine-protein kinase Blk
type: ProteinReference
xref: uniprot P16277 801
xref: PTHR24418:SF181
organism: Mus musculus

uniprot A5PKJ4 267
type: UnificationXref
id: A5PKJ4
db: uniprot

STATE_TRANSITION_LEFT__O2-RIGHT__H2O2-_r39
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 1332
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 1333
left: O2
interaction type: STATE_TRANSITION
right: H2O2

Ubc7
type: ProteinReference
xref: P01220
standard name: Ubiquitin-conjugating enzyme 7
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Parkinson disease.PROTEIN.GENERIC.Ubc7
comment: ENTITY_REFERENCE_NOTES= Long Name: Ubiquitin-conjugating enzyme 7 Synonym: Synonym not specified Accession: P01220
member entity reference: AGAP002169-PA
member entity reference: RE34144p

uniprot Q8TD08 320
type: UnificationXref
id: Q8TD08
db: uniprot

Casein kinase I isoform alpha
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot P42168 1151
organism: Caenorhabditis elegans

uniprot Q10329 654
type: UnificationXref
id: Q10329
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A0A2I3RZ31 412
organism: Pan troglodytes

Probable proteasome subunit alpha type-1
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot O94517 611
organism: Schizosaccharomyces pombe

Proteasome subunit beta
type: ProteinReference
xref: PTHR11599:SF174
xref: uniprot Q1LWY1 656
organism: Danio rerio

uniprot F6PKK7 767
type: UnificationXref
id: F6PKK7
db: uniprot

uniprot Q8S1J0 1181
type: UnificationXref
id: Q8S1J0
db: uniprot

Proto-oncogene tyrosine-protein kinase Src
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot P12931 799
organism: Homo sapiens

Septin-2
type: ProteinReference
xref: uniprot Q91Y81 523
organism: Rattus norvegicus

uniprot Q74ZU1 1067
type: UnificationXref
id: Q74ZU1
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot Q91Y86 443
organism: Mus musculus

uniprot A7MB90 1118
type: UnificationXref
id: A7MB90
db: uniprot

uniprot Q4QC13 676
type: UnificationXref
id: Q4QC13
db: uniprot

uniprot H9ENR6 894
type: UnificationXref
id: H9ENR6
db: uniprot

uniprot P05480 789
type: UnificationXref
id: P05480
db: uniprot

ncbitaxon 272561 143
type: UnificationXref
id: 272561
db: ncbitaxon

PTHR11599:SF5
type: RelationshipXref
id: PTHR11599:SF5
db: PANTHER Family
relationship type: By Homology

PTHR24418:SF90
type: RelationshipXref
id: PTHR24418:SF90
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR24068:SF67
xref: uniprot A0A1D5QQB8 481
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H4X8 829
organism: Macaca mulatta

uniprot P63018 172
type: UnificationXref
id: P63018
db: uniprot

uniprot P0CS90 122
type: UnificationXref
id: P0CS90
db: uniprot

uniprot Q11179 299
type: UnificationXref
id: Q11179
db: uniprot

uniprot D4A4T0 359
type: UnificationXref
id: D4A4T0
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
type: ProteinReference
xref: PTHR18860:SF16
xref: uniprot H2QLJ0 1002
organism: Pan troglodytes

uniprot F1Q5N4 558
type: UnificationXref
id: F1Q5N4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__alpha_Synuclein-RIGHT__alpha_Synuclein-_r45
controller: Src kinase

uniprot P27348 1008
type: UnificationXref
id: P27348
db: uniprot

14-3-3 protein epsilon
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot Q7PX08 1068
organism: Anopheles gambiae

Probable mediator of RNA polymerase II transcription subunit 37c
type: ProteinReference
xref: PTHR19375:SF413
xref: uniprot Q9LHA8 246
organism: Arabidopsis thaliana

uniprot A9TWR9 56
type: UnificationXref
id: A9TWR9
db: uniprot

PTHR11473:SF18
type: RelationshipXref
id: PTHR11473:SF18
db: PANTHER Family
relationship type: By Homology

uniprot P67870 919
type: UnificationXref
id: P67870
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 108

Ashbya gossypii
type: BioSource
xref: ncbitaxon 284811 218

14-3-3 zeta
type: ProteinReference
xref: PTHR18860:SF106
xref: uniprot A8XQR9 969
organism: Caenorhabditis briggsae

uniprot B8BWB9 62
type: UnificationXref
id: B8BWB9
db: uniprot

uniprot P20618 619
type: UnificationXref
id: P20618
db: uniprot

uniprot A0A1D5PXC6 411
type: UnificationXref
id: A0A1D5PXC6
db: uniprot

Proteasome subunit beta
type: ProteinReference
xref: uniprot A8WUP0 532
xref: PTHR11599:SF62
organism: Caenorhabditis briggsae

uniprot C4M3S5 64
type: UnificationXref
id: C4M3S5
db: uniprot

PTHR24418:SF42
type: RelationshipXref
id: PTHR24418:SF42
db: PANTHER Family
relationship type: By Homology

Probable proteasome subunit alpha type-2
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot Q8X077 708
organism: Neurospora crassa

STIP1 homology and U-box containing protein 1
type: ProteinReference
xref: PTHR46803:SF2
xref: uniprot E1B7G3 360
organism: Bos taurus

PTHR24418:SF44
type: RelationshipXref
id: PTHR24418:SF44
db: PANTHER Family
relationship type: By Homology

Casein kinase I isoform delta
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot P35508 1145
organism: Bos taurus

uniprot F6TLV2 80
type: UnificationXref
id: F6TLV2
db: uniprot

uniprot Q9VJC2 1198
type: UnificationXref
id: Q9VJC2
db: uniprot

Casein kinase I isoform beta
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot P35507 1144
organism: Bos taurus

ncbitaxon 367110 175
type: UnificationXref
id: 367110
db: ncbitaxon

Proteasome subunit alpha type-5
type: ProteinReference
xref: uniprot Q5E987 680
xref: PTHR11599:SF14
organism: Bos taurus

PTHR24418:SF39
type: RelationshipXref
id: PTHR24418:SF39
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r48 1297
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r48 1298
type: Stoichiometry
physical entity: Complex (Parkin/Pael-R)
stoichiometric coefficient: 1.0

PTHR24055:SF110
type: RelationshipXref
id: PTHR24055:SF110
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r48 1296
type: Stoichiometry
physical entity: Pael-R
stoichiometric coefficient: 1.0

uniprot Q6P0I2 688
type: UnificationXref
id: Q6P0I2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Elk_1-RIGHT__Elk_1-_r35
controller: alpha-Synuclein

PTHR24418:SF53
type: RelationshipXref
id: PTHR24418:SF53
db: PANTHER Family
relationship type: By Homology

uniprot Q3MHP1 490
type: UnificationXref
id: Q3MHP1
db: uniprot

uniprot A0A1D5QL29 527
type: UnificationXref
id: A0A1D5QL29
db: uniprot

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 824

uniprot F7B5L8 426
type: UnificationXref
id: F7B5L8
db: uniprot

PTHR24055:SF146
type: RelationshipXref
id: PTHR24055:SF146
db: PANTHER Family
relationship type: By Homology

Cytoplasmic heat shock protein 70
type: ProteinReference
xref: uniprot A2E4W5 29
xref: PTHR19375:SF395
organism: Trichomonas vaginalis

uniprot A8X8G7 534
type: UnificationXref
id: A8X8G7
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot V5IKE7 334
organism: Neurospora crassa

PARTICIPANT STOICHIOMETRY r55 1375
type: Stoichiometry
physical entity: alpha-Synuclein
stoichiometric coefficient: 1.0

uniprot H2QED5 584
type: UnificationXref
id: H2QED5
db: uniprot

Heat shock protein 70B
type: ProteinReference
xref: uniprot A8HYV3 42
xref: PTHR19375:SF184
organism: Chlamydomonas reinhardtii

PARTICIPANT STOICHIOMETRY r55 1376
type: Stoichiometry
physical entity: Complex (O-glyc/alpha-Synuclein)
stoichiometric coefficient: 1.0

ncbitaxon 83333 120
type: UnificationXref
id: 83333
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot H3FYW1 103
xref: PTHR19375:SF457
organism: Pristionchus pacificus

uniprot P48721 167
type: UnificationXref
id: P48721
db: uniprot

uniprot E1BYW9 544
type: UnificationXref
id: E1BYW9
db: uniprot

PLD2
type: Protein
entity reference: PLD2
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PTHR24418:SF431
type: RelationshipXref
id: PTHR24418:SF431
db: PANTHER Family
relationship type: By Homology

uniprot P70195 650
type: UnificationXref
id: P70195
db: uniprot

uniprot Q9XAQ8 962
type: UnificationXref
id: Q9XAQ8
db: uniprot

uniprot H2QQA2 1102
type: UnificationXref
id: H2QQA2
db: uniprot

PTHR24055:SF162
type: RelationshipXref
id: PTHR24055:SF162
db: PANTHER Family
relationship type: By Homology

Complex (TH/Parkin)
type: Complex
component stoichiometry: TH s97 sa32 STOICHIOMETRY ID COMPLEX
component stoichiometry: Parkin s98 sa33 STOICHIOMETRY ID COMPLEX
component: Parkin
component: TH
feature: COMPLEX BINDING FEATURE s112 a156 1239
feature: COMPLEX BINDING FEATURE s112 a156 1241
cellular location: intracellular

uniprot Q6H800 686
type: UnificationXref
id: Q6H800
db: uniprot

uniprot H2Q2W7 1108
type: UnificationXref
id: H2Q2W7
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LTT9 335
xref: PTHR24055:SF110
organism: Bos taurus

Iron
type: SmallMolecule
cellular location: mitochondrion
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Cyclin E
type: Protein
entity reference: Cyclin E
feature: ACTIVE 21
feature: Cyclin E s84 a113 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Alpha-synuclein
type: ProteinReference
xref: PTHR13820:SF5
xref: uniprot P37377 403
organism: Rattus norvegicus

PTHR24055:SF158
type: RelationshipXref
id: PTHR24055:SF158
db: PANTHER Family
relationship type: By Homology

uniprot F1NQ71 349
type: UnificationXref
id: F1NQ71
db: uniprot

Heat shock 70 kDa protein 1-like
type: ProteinReference
xref: PTHR19375:SF210
xref: uniprot P34931 157
organism: Homo sapiens

uniprot A1L0Y5 499
type: UnificationXref
id: A1L0Y5
db: uniprot

uniprot O55042 402
type: UnificationXref
id: O55042
db: uniprot

uniprot Q7Q5D3 822
type: UnificationXref
id: Q7Q5D3
db: uniprot

Thalassiosira pseudonana
type: BioSource
xref: ncbitaxon 35128 63

uniprot Q38DP7 669
type: UnificationXref
id: Q38DP7
db: uniprot

uniprot F7BEI4 351
type: UnificationXref
id: F7BEI4
db: uniprot

uniprot A7UT42 36
type: UnificationXref
id: A7UT42
db: uniprot

RE34144p
type: ProteinReference
xref: PTHR24067:SF154
xref: uniprot Q9VXE8 448
organism: Drosophila melanogaster

Sodium-dependent dopamine transporter
type: ProteinReference
xref: uniprot P23977 737
xref: PTHR11616:SF38
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r42 1320
type: Stoichiometry
physical entity: Complex (Synphilin/Parkin)
stoichiometric coefficient: 1.0

uniprot F7EIY0 573
type: UnificationXref
id: F7EIY0
db: uniprot

PARTICIPANT STOICHIOMETRY r42 1321
type: Stoichiometry
physical entity: a92_degraded
stoichiometric coefficient: 1.0

PTHR11909:SF388
type: RelationshipXref
id: PTHR11909:SF388
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F7BHF8 773
xref: PTHR24418:SF224
organism: Macaca mulatta

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 872

Casein kinase I isoform delta-A
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot Q7T2E3 1172
organism: Danio rerio

uniprot F7C5A3 854
type: UnificationXref
id: F7C5A3
db: uniprot

PTHR11909:SF391
type: RelationshipXref
id: PTHR11909:SF391
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r71 1329
type: Stoichiometry
physical entity: Complex (CDCrel-1/Syntaxin)
stoichiometric coefficient: 1.0

PTHR11909:SF395
type: RelationshipXref
id: PTHR11909:SF395
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r71 1327
type: Stoichiometry
physical entity: Syntaxin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r71 1328
type: Stoichiometry
physical entity: CDCrel-1
stoichiometric coefficient: 1.0

70 kDa heat shock protein
type: ProteinReference
xref: PTHR19375:SF391
xref: uniprot Q943K7 237
organism: Oryza sativa

uniprot P39962 1146
type: UnificationXref
id: P39962
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot H2QLB4 284
organism: Pan troglodytes

Proteasome subunit alpha type-6
type: ProteinReference
xref: PTHR11599:SF11
xref: uniprot Q9XZJ4 732
organism: Drosophila melanogaster

14-3-3-like protein GF14-D
type: ProteinReference
xref: uniprot Q2R2W2 1047
xref: PTHR18860:SF69
organism: Oryza sativa

Cullin 1a
type: ProteinReference
xref: PTHR11932:SF81
xref: uniprot Q6NYS3 1091
organism: Danio rerio

PTHR24055:SF172
type: RelationshipXref
id: PTHR24055:SF172
db: PANTHER Family
relationship type: By Homology

PTHR24418:SF419
type: RelationshipXref
id: PTHR24418:SF419
db: PANTHER Family
relationship type: By Homology

uniprot P29310 1009
type: UnificationXref
id: P29310
db: uniprot

uniprot Q60737 928
type: UnificationXref
id: Q60737
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot A0A1D5Q5Z6 265
organism: Macaca mulatta

Parkin s96 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Parkin
stoichiometric coefficient: 1.0

PTHR11909:SF367
type: RelationshipXref
id: PTHR11909:SF367
db: PANTHER Family
relationship type: By Homology

PTHR11909:SF366
type: RelationshipXref
id: PTHR11909:SF366
db: PANTHER Family
relationship type: By Homology

Y125 alpha Synuclein s2 a2 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y125
feature location: Y125 alpha Synuclein s2 a2 rs2 Y125
comment: MODIFICATION_RESIDUE_NAME=Y125
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.69

p38 MAPK s74 a99 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Chaperone protein DnaK
type: ProteinReference
xref: PTHR19375:SF184
xref: uniprot Q9WYK6 253
organism: Thermotoga maritima

uniprot P42656 1018
type: UnificationXref
id: P42656
db: uniprot

S129 alpha Synuclein s78 sa21 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S129
feature location: S129 alpha Synuclein s78 sa21 rs1 S129
comment: MODIFICATION_RESIDUE_NAME=S129
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

Proteasome subunit alpha type-3
type: ProteinReference
xref: uniprot O23715 599
xref: PTHR11599:SF10
organism: Arabidopsis thaliana

uniprot F6WBW6 279
type: UnificationXref
id: F6WBW6
db: uniprot

PTHR11909:SF374
type: RelationshipXref
id: PTHR11909:SF374
db: PANTHER Family
relationship type: By Homology

uniprot A9JTQ9 464
type: UnificationXref
id: A9JTQ9
db: uniprot

PTHR24055:SF196
type: RelationshipXref
id: PTHR24055:SF196
db: PANTHER Family
relationship type: By Homology

alpha Synuclein s2 a2 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.528611247526151

PTHR11909:SF378
type: RelationshipXref
id: PTHR11909:SF378
db: PANTHER Family
relationship type: By Homology

Casein kinase I isoform alpha
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot P67962 1157
organism: Gallus gallus

Proteasome subunit beta type-7-A
type: ProteinReference
xref: PTHR11599:SF44
xref: uniprot O23710 598
organism: Arabidopsis thaliana

uniprot P68510 1038
type: UnificationXref
id: P68510
db: uniprot

uniprot O70456 1007
type: UnificationXref
id: O70456
db: uniprot

Sodium-dependent dopamine transporter
type: DnaReference
xref: PTHR11616:SF38
organism: Mus musculus

Casein kinase I isoform alpha
type: ProteinReference
xref: PTHR11909:SF20
xref: uniprot Q8BK63 1173
organism: Mus musculus

Proteasome subunit alpha type-2-A
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot O23708 597
organism: Arabidopsis thaliana

Casein kinase I isoform gamma-3
type: ProteinReference
xref: PTHR11909:SF151
xref: uniprot Q8C4X2 1175
organism: Mus musculus

uniprot Q0J006 653
type: UnificationXref
id: Q0J006
db: uniprot

PTHR11909:SF383
type: RelationshipXref
id: PTHR11909:SF383
db: PANTHER Family
relationship type: By Homology

uniprot F6X2V7 1084
type: UnificationXref
id: F6X2V7
db: uniprot

Probable proteasome subunit alpha type-2
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot O94579 612
organism: Schizosaccharomyces pombe

uniprot Q99JG2 746
type: UnificationXref
id: Q99JG2
db: uniprot

alpha Synuclein s2 a2 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

STATE_TRANSITION_LEFT__Ub-_Complex__Parkin_Pael_R_-RIGHT__Complex__Parkin_Pael_R_-_r49
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 1294
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 1293
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 1295
left: Complex (Parkin/Pael-R)
left: Ub
interaction type: STATE_TRANSITION
right: Complex (Parkin/Pael-R)

Casein kinase II, alpha chain, putative, expressed
type: ProteinReference
xref: PTHR24054:SF35
xref: uniprot Q10Q71 924
organism: Oryza sativa

uniprot P47794 356
type: UnificationXref
id: P47794
db: uniprot

uniprot Q06967 1043
type: UnificationXref
id: Q06967
db: uniprot

uniprot H2RBN7 945
type: UnificationXref
id: H2RBN7
db: uniprot

Complex (19S proteasome/20S proteasome)
type: Complex
component stoichiometry: 19S proteasome s22 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: 20S proteasome s23 sa2 STOICHIOMETRY ID COMPLEX
component: 19S proteasome
component: 20S proteasome
feature: COMPLEX BINDING FEATURE s31 a39 1277
feature: COMPLEX BINDING FEATURE s31 a39 1279
cellular location: intracellular

uniprot E1BIM8 759
type: UnificationXref
id: E1BIM8
db: uniprot

Elk-1
type: Protein
entity reference: Elk-1
feature: Elk 1 s53 a77 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q5SRY7 1103
type: UnificationXref
id: Q5SRY7
db: uniprot

uniprot Q39233 384
type: UnificationXref
id: Q39233
db: uniprot

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: uniprot P36604 160
xref: PTHR19375:SF144
organism: Schizosaccharomyces pombe

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF14
xref: uniprot Q6TGV6 690
organism: Danio rerio

PTHR11909:SF353
type: RelationshipXref
id: PTHR11909:SF353
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot F6TNW3 984
organism: Ciona intestinalis

PTHR11909:SF356
type: RelationshipXref
id: PTHR11909:SF356
db: PANTHER Family
relationship type: By Homology

PTHR11909:SF355
type: RelationshipXref
id: PTHR11909:SF355
db: PANTHER Family
relationship type: By Homology

Proteasome subunit alpha type
type: ProteinReference
xref: PTHR11599:SF16
xref: uniprot H2R5C6 589
organism: Pan troglodytes

14-3-3
type: Protein
entity reference: 14-3-3
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa7 1266
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
type: ProteinReference
xref: uniprot A0A2J8MKA4 964
xref: PTHR18860:SF28
organism: Pan troglodytes

uniprot Q7PVR1 316
type: UnificationXref
id: Q7PVR1
db: uniprot

uniprot Q9JMK2 1191
type: UnificationXref
id: Q9JMK2
db: uniprot

uniprot E9H8M4 979
type: UnificationXref
id: E9H8M4
db: uniprot

Proteasome subunit alpha type-7
type: ProteinReference
xref: uniprot O14818 595
xref: PTHR11599:SF40
organism: Homo sapiens

Beta-synuclein
type: ProteinReference
xref: uniprot Q16143 398
xref: PTHR13820:SF4
organism: Homo sapiens