UDP-N-acetylglucosamine 1-carboxyvinyltransferase
type: ProteinReference
xref: uniprot Q9WXW3 36
organism: Thermotoga maritima

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__UTP-_N_acetyl_glucosamine_1_phosphate-RIGHT__PPi-_UDP_N_acetyl_D_glucosamine-_r1
controller: N-acetylglucosamine-1-phosphate uridyltransferase

STATE_TRANSITION_LEFT__phosphoenolpyruvate-_UDP_N_acetyl_D_glucosamine-RIGHT__UDP_N_acetyl_3__1_carboxyvinyl__D_glucosamine-_PO4-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 103
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 102
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 101
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 100
left: phosphoenolpyruvate
left: UDP-N-acetyl-D-glucosamine
interaction type: STATE_TRANSITION
right: PO4
right: UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine

uniprot O66806 76
type: UnificationXref
id: O66806
db: uniprot

STATE_TRANSITION_LEFT__UDP_N_acetymuramate-_ATP-_alanine-RIGHT__UDP_N_acetylmuramoyl_alanine-_PO4-_ADP-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 92
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 91
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 93
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 95
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 90
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 94
left: alanine
left: ATP
left: UDP-N-acetymuramate
interaction type: STATE_TRANSITION
right: UDP-N-acetylmuramoyl-alanine
right: PO4
right: ADP

UDP-N-acetylmuramate dehydrogenase
type: ProteinReference
xref: P03088
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: UDP-N-acetylmuramate dehydrogenase Synonym: Synonym not specified Accession: P03088
comment: ENTITY_REFERENCE_ID_DESC=Peptidoglycan biosynthesis.PROTEIN.GENERIC.UDP-N-acetylmuramate_br_dehydrogenase
member entity reference: UDP-N-acetylenolpyruvoylglucosamine reductase

UDP-3-O-acyl-N-acetylglucosamine deacetylase
type: ProteinReference
xref: uniprot Q7NJG7 66
organism: Gloeobacter violaceus

N-acetylglucosamine-1-phosphate uridyltransferase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q8F4J4 30
type: UnificationXref
id: Q8F4J4
db: uniprot

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O84766 61
type: UnificationXref
id: O84766
db: uniprot

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 9

ncbitaxon 272561 5
type: UnificationXref
id: 272561
db: ncbitaxon

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase
type: ProteinReference
xref: uniprot Q9WY79 35
organism: Thermotoga maritima

uniprot O67631 22
type: UnificationXref
id: O67631
db: uniprot

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
type: ProteinReference
xref: uniprot Q9WY74 74
organism: Thermotoga maritima

UDP-N-acetylmuramoylalanine--D-glutamate ligase
type: ProteinReference
xref: uniprot Q9WY76 18
organism: Thermotoga maritima

PARTICIPANT STOICHIOMETRY r6 137
type: Stoichiometry
physical entity: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 136
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q9EX22 46
type: UnificationXref
id: Q9EX22
db: uniprot

D-alanine--D-alanine ligase
type: ProteinReference
xref: uniprot Q8A1F3 82
organism: Bacteroides thetaiotaomicron

PARTICIPANT STOICHIOMETRY r6 133
type: Stoichiometry
physical entity: UDP-N-acetylmurmoyl-L-alanyl-D-glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 132
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 135
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

uniprot Q8A1E4 43
type: UnificationXref
id: Q8A1E4
db: uniprot

PARTICIPANT STOICHIOMETRY r6 134
type: Stoichiometry
physical entity: meso-diaminopimelate
stoichiometric coefficient: 1.0

uniprot O84763 4
type: UnificationXref
id: O84763
db: uniprot

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 5

uniprot Q7NJG7 66
type: UnificationXref
id: Q7NJG7
db: uniprot

uniprot Q9EX00 71
type: UnificationXref
id: Q9EX00
db: uniprot

Probable D-alanine-D-alanine ligase
type: ProteinReference
xref: uniprot Q7UHD8 81
organism: Rhodopirellula baltica

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 19

D-alanyl-D-alanine-adding enzyme
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q8F4I2 84
type: UnificationXref
id: Q8F4I2
db: uniprot

UDP-N-acetyl-glucosamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

UDP-N-acetylmuramyl-tripeptide synthetase
type: ProteinReference
xref: uniprot Q9RXL3 33
organism: Deinococcus radiodurans

ncbitaxon 243090 28
type: UnificationXref
id: 243090
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9EX00 71
organism: Streptomyces coelicolor

CATALYSIS
type: Catalysis
controlled: STATE TRANSITION LEFT ATP- D alanyl D alanine- UDP N acetylmuramoyl L alanyl D glutamyl meso 2,6 diaminoheptanedioate-RIGHT UDP N acetylmuramoyl L meso 2,6 diaminoheptanedioate D alanyl D alanine- PO4- ADP- r9
controller: D-alanyl-D-alanine-adding enzyme

uniprot Q7NGE2 65
type: UnificationXref
id: Q7NGE2
db: uniprot

Glutamate racemase
type: ProteinReference
xref: uniprot Q7NKI2 42
organism: Gloeobacter violaceus

STATE TRANSITION LEFT UDP N acetyl glucosamine- N acetyl L alanyl D glutamyl meso 2,6 diaminoheptane D alanyl D alanine diphosphoundecaprenol-RIGHT UDP undecaprenyl pyrophosphoryl MurNAc pentapeptide N acetylglucosamine- r11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 109
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 110
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 108
left: N-acetyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptane-D-alanyl-D-alanine-diphosphoundecaprenol
left: UDP-N-acetyl-glucosamine
display name: STATE_TRANSITION_LEFT__UDP_N_acetyl_glucosamine-_N_acetyl_L_alanyl_D_glutamyl_meso_2,6_diaminoheptane_D_alanyl_D_alanine_diphosphoundecaprenol-RIGHT__UDP_undecaprenyl_pyrophosphoryl_MurNAc__pentapeptide__N_acetylglucosamine-_r11
interaction type: STATE_TRANSITION
right: UDP-undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)-N-acetylglucosamine

uniprot Q9WY79 35
type: UnificationXref
id: Q9WY79
db: uniprot

Glr3229 protein
type: ProteinReference
xref: uniprot Q7NGE2 65
organism: Gloeobacter violaceus

UMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 226186 11
type: UnificationXref
id: 226186
db: ncbitaxon

UDP-N-acetylmuramoylalanine-D-glutamate ligase
type: ProteinReference
xref: P03083
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Peptidoglycan biosynthesis.PROTEIN.GENERIC.UDP-N-acetylmuramoylalanine-_br_D-glutamate ligase
comment: ENTITY_REFERENCE_NOTES= Long Name: UDP-N-acetylmuramoylalanine-D-glutamate ligase Synonym: Synonym not specified Accession: P03083
member entity reference: UDP-N-acetylmuramoylalanine--D-glutamate ligase

uniprot Q7UHD8 81
type: UnificationXref
id: Q7UHD8
db: uniprot

uniprot C0SPB9 59
type: UnificationXref
id: C0SPB9
db: uniprot

NADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

D-alanine--D-alanine ligase
type: ProteinReference
xref: uniprot P96612 79
organism: Bacillus subtilis

D-alanine--D-alanine ligase
type: ProteinReference
xref: uniprot P46805 78
organism: Thermotoga maritima

N-acetyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptane-D-alanyl-D-alanine-diphosphoundecaprenol
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE homolog, chloroplastic
type: ProteinReference
xref: uniprot F4I3P9 20
organism: Arabidopsis thaliana

uniprot Q9X239 58
type: UnificationXref
id: Q9X239
db: uniprot

PARTICIPANT STOICHIOMETRY r4 90
type: Stoichiometry
physical entity: UDP-N-acetymuramate
stoichiometric coefficient: 1.0

uniprot Q9WY76 18
type: UnificationXref
id: Q9WY76
db: uniprot

Glutamate racemase
type: ProteinReference
xref: uniprot Q8REE6 45
organism: Fusobacterium nucleatum

uniprot Q9WY74 74
type: UnificationXref
id: Q9WY74
db: uniprot

PARTICIPANT STOICHIOMETRY r4 92
type: Stoichiometry
physical entity: alanine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 91
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE TRANSITION LEFT undecaprenyl phosphate- UDP N acetylmuramoyl L meso 2,6 diaminoheptanedioate D alanyl D alanine-RIGHT UMP- N acetyl L alanyl D glutamyl meso 2,6 diaminoheptane D alanyl D alanine diphosphoundecaprenol- r10
controller: Phospho-N-acetylmuramoyl pentapeptide transferase

D-alanine--D-alanine ligase
type: ProteinReference
xref: uniprot Q7NNW1 80
organism: Gloeobacter violaceus

uniprot Q8R5N5 69
type: UnificationXref
id: Q8R5N5
db: uniprot

PARTICIPANT STOICHIOMETRY r4 94
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 93
type: Stoichiometry
physical entity: UDP-N-acetylmuramoyl-alanine
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__UTP-_N_acetyl_glucosamine_1_phosphate-RIGHT__PPi-_UDP_N_acetyl_D_glucosamine-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 106
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 105
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 107
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 104
left: N-acetyl-glucosamine-1-phosphate
left: UTP
interaction type: STATE_TRANSITION
right: PPi
right: UDP-N-acetyl-D-glucosamine

PARTICIPANT STOICHIOMETRY r4 95
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q7NKI2 42
type: UnificationXref
id: Q7NKI2
db: uniprot

Cell wall synthesis protein, putative
type: ProteinReference
xref: uniprot Q9RVF3 72
organism: Deinococcus radiodurans

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 11

UDP-N-acetylenolpyruvoylglucosamine reductase
type: ProteinReference
xref: uniprot P0CD77 50
organism: Chlamydia trachomatis

STATE_TRANSITION_LEFT__ATP-_UDP_N_acetylmurmoyl_L_alanyl_D_glutamate-_meso_diaminopimelate-RIGHT__PO4-_ADP-_UDP_N_acetylmuramoyl_L_alanyl_D_glutamyl_meso_2,6_diaminoheptanedioate-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 136
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 134
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 135
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 132
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 133
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 137
left: ATP
left: meso-diaminopimelate
left: UDP-N-acetylmurmoyl-L-alanyl-D-glutamate
interaction type: STATE_TRANSITION
right: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate
right: PO4
right: ADP

uniprot Q8F4J1 68
type: UnificationXref
id: Q8F4J1
db: uniprot

alanine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r7 130
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

uniprot Q8RDQ4 85
type: UnificationXref
id: Q8RDQ4
db: uniprot

PARTICIPANT STOICHIOMETRY r7 131
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

N-Acetylglucosaminyl transferase
type: Protein
entity reference: N-Acetylglucosaminyl transferase
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r5 89
type: Stoichiometry
physical entity: D-glutamate
stoichiometric coefficient: 1.0

UDP-N-acetylmuramate alanine ligase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Glutamate racemase
type: ProteinReference
xref: uniprot Q8F1S7 44
organism: Leptospira interrogans

PARTICIPANT STOICHIOMETRY r5 88
type: Stoichiometry
physical entity: L-glutamate
stoichiometric coefficient: 1.0

ncbitaxon 251221 9
type: UnificationXref
id: 251221
db: ncbitaxon

uniprot Q7NDB0 25
type: UnificationXref
id: Q7NDB0
db: uniprot

ncbitaxon 243274 19
type: UnificationXref
id: 243274
db: ncbitaxon

UDP-N-acetylenolpyruvoylglucosamine reductase
type: ProteinReference
xref: uniprot Q7NJQ2 52
organism: Gloeobacter violaceus

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r7 128
type: Stoichiometry
physical entity: D-glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 129
type: Stoichiometry
physical entity: UDP-N-acetylmurmoyl-L-alanyl-D-glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 126
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 127
type: Stoichiometry
physical entity: UDP-N-acetylmuramoyl-alanine
stoichiometric coefficient: 1.0

ncbitaxon 224308 7
type: UnificationXref
id: 224308
db: ncbitaxon

uniprot Q9C9T8 70
type: UnificationXref
id: Q9C9T8
db: uniprot

UDP-undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)-N-acetylglucosamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8EZC5 54
type: UnificationXref
id: Q8EZC5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__UDP_N_acetymuramate-_ATP-_alanine-RIGHT__UDP_N_acetylmuramoyl_alanine-_PO4-_ADP-_r4
controller: UDP-N-acetylmuramate alanine ligase

PPi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9RWN8 57
type: UnificationXref
id: Q9RWN8
db: uniprot

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
type: ProteinReference
xref: uniprot Q9ZBA5 75
organism: Streptomyces coelicolor

ncbitaxon 224324 3
type: UnificationXref
id: 224324
db: ncbitaxon

uniprot Q7UQT1 27
type: UnificationXref
id: Q7UQT1
db: uniprot

UDP-N-acetylenolpyruvoylglucosamine reductase
type: ProteinReference
xref: uniprot P18579 51
organism: Bacillus subtilis

D-alanine--D-alanine ligase
type: ProteinReference
xref: uniprot Q9ZBR9 87
organism: Streptomyces coelicolor

CATALYSIS
type: Catalysis
controlled: STATE TRANSITION LEFT UDP N acetyl glucosamine- N acetyl L alanyl D glutamyl meso 2,6 diaminoheptane D alanyl D alanine diphosphoundecaprenol-RIGHT UDP undecaprenyl pyrophosphoryl MurNAc pentapeptide N acetylglucosamine- r11
controller: N-Acetylglucosaminyl transferase

uniprot Q9RXL3 33
type: UnificationXref
id: Q9RXL3
db: uniprot

2 D-alanine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phosphoenolpyruvate-_UDP_N_acetyl_D_glucosamine-RIGHT__UDP_N_acetyl_3__1_carboxyvinyl__D_glucosamine-_PO4-_r2
controller: N-acetylglucosamine-enoylpyruvoyl transferase

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 13

uniprot Q7NNW1 80
type: UnificationXref
id: Q7NNW1
db: uniprot

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 15

Uncharacterized glycosyltransferase YkoN
type: ProteinReference
xref: uniprot C0SPB9 59
organism: Bacillus subtilis

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
type: ProteinReference
xref: uniprot Q9S2W7 34
organism: Streptomyces coelicolor

Glutamate racemase
type: Protein
entity reference: Glutamate racemase
comment: SPECIES_TYPE=PROTEIN

UDP-N-acetylmuramoylalanine--D-glutamate ligase
type: ProteinReference
xref: uniprot Q9S2W9 16
organism: Streptomyces coelicolor

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
type: ProteinReference
xref: uniprot Q8A254 29
organism: Bacteroides thetaiotaomicron

UDP-N-acetylmuramoylalanine--D-glutamate ligase
type: ProteinReference
xref: uniprot Q8A256 10
organism: Bacteroides thetaiotaomicron

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
type: ProteinReference
xref: uniprot Q8A258 67
organism: Bacteroides thetaiotaomicron

Glutamate racemase
type: ProteinReference
xref: uniprot Q8A1E4 43
organism: Bacteroides thetaiotaomicron

Probable UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase
type: ProteinReference
xref: uniprot Q7UQT1 27
organism: Rhodopirellula baltica

D-alanine--D-alanine ligase
type: ProteinReference
xref: uniprot Q8F4I2 84
organism: Leptospira interrogans

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 21

Glutamate racemase 1
type: ProteinReference
xref: uniprot P94556 41
organism: Bacillus subtilis

Peptidoglycan biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__ATP-_UDP_N_acetylmuramoyl_alanine-_D_glutamate-RIGHT__UDP_N_acetylmurmoyl_L_alanyl_D_glutamate-_PO4-_ADP-_r7
pathway component: STATE_TRANSITION_LEFT__UTP-_N_acetyl_glucosamine_1_phosphate-RIGHT__PPi-_UDP_N_acetyl_D_glucosamine-_r1
pathway component: STATE_TRANSITION_LEFT__phosphoenolpyruvate-_UDP_N_acetyl_D_glucosamine-RIGHT__UDP_N_acetyl_3__1_carboxyvinyl__D_glucosamine-_PO4-_r2
pathway component: STATE TRANSITION LEFT undecaprenyl phosphate- UDP N acetylmuramoyl L meso 2,6 diaminoheptanedioate D alanyl D alanine-RIGHT UMP- N acetyl L alanyl D glutamyl meso 2,6 diaminoheptane D alanyl D alanine diphosphoundecaprenol- r10
pathway component: STATE_TRANSITION_LEFT__UDP_N_acetyl_3__1_carboxyvinyl__D_glucosamine-_NADPH-RIGHT__NADP-_UDP_N_acetymuramate-_r3
pathway component: STATE_TRANSITION_LEFT__ATP-_UDP_N_acetylmurmoyl_L_alanyl_D_glutamate-_meso_diaminopimelate-RIGHT__PO4-_ADP-_UDP_N_acetylmuramoyl_L_alanyl_D_glutamyl_meso_2,6_diaminoheptanedioate-_r6
pathway component: STATE_TRANSITION_LEFT__ATP-_2_D_alanine-RIGHT__PO4-_D_alanyl_D_alanine-_ADP-_r8
pathway component: STATE TRANSITION LEFT ATP- D alanyl D alanine- UDP N acetylmuramoyl L alanyl D glutamyl meso 2,6 diaminoheptanedioate-RIGHT UDP N acetylmuramoyl L meso 2,6 diaminoheptanedioate D alanyl D alanine- PO4- ADP- r9
pathway component: STATE_TRANSITION_LEFT__L_glutamate-RIGHT__D_glutamate-_r5
pathway component: STATE_TRANSITION_LEFT__UDP_N_acetymuramate-_ATP-_alanine-RIGHT__UDP_N_acetylmuramoyl_alanine-_PO4-_ADP-_r4
pathway component: STATE TRANSITION LEFT UDP N acetyl glucosamine- N acetyl L alanyl D glutamyl meso 2,6 diaminoheptane D alanyl D alanine diphosphoundecaprenol-RIGHT UDP undecaprenyl pyrophosphoryl MurNAc pentapeptide N acetylglucosamine- r11
xref: PANTHER Pathway P02763 1
comment: MODEL_NOTES= The peptidoglycan layer is a structural component of gram negative bacterial cell walls. It is a cross linking network of aminosugars and small peptides that provides the cell protection from osmotic rupture. Website=www.biocyc.org/Ecoli/Pathways/ free text=Voet and Voet (textbook) Biochemistry

uniprot Q9S2W9 16
type: UnificationXref
id: Q9S2W9
db: uniprot

UDP-N-acetylenolpyruvoylglucosamine reductase
type: ProteinReference
xref: uniprot Q8EZC5 54
organism: Leptospira interrogans

UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase
type: Protein
entity reference: UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase
comment: SPECIES_TYPE=PROTEIN

uniprot Q7NJQ2 52
type: UnificationXref
id: Q7NJQ2
db: uniprot

undecaprenyl phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
type: ProteinReference
xref: uniprot Q8F4J4 30
organism: Leptospira interrogans

ncbitaxon 189518 13
type: UnificationXref
id: 189518
db: ncbitaxon

UDP-N-acetylenolpyruvoylglucosamine reductase
type: ProteinReference
xref: uniprot Q8RDQ3 55
organism: Fusobacterium nucleatum

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
type: ProteinReference
xref: uniprot Q8R5N5 69
organism: Fusobacterium nucleatum

D-alanine--D-alanine ligase
type: ProteinReference
xref: uniprot Q8RDQ4 85
organism: Fusobacterium nucleatum

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
type: ProteinReference
xref: uniprot Q8F4J1 68
organism: Leptospira interrogans

PARTICIPANT STOICHIOMETRY r1 105
type: Stoichiometry
physical entity: N-acetyl-glucosamine-1-phosphate
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_UDP_N_acetylmurmoyl_L_alanyl_D_glutamate-_meso_diaminopimelate-RIGHT__PO4-_ADP-_UDP_N_acetylmuramoyl_L_alanyl_D_glutamyl_meso_2,6_diaminoheptanedioate-_r6
controller: UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase

PARTICIPANT STOICHIOMETRY r1 104
type: Stoichiometry
physical entity: UTP
stoichiometric coefficient: 1.0

ncbitaxon 100226 17
type: UnificationXref
id: 100226
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r1 107
type: Stoichiometry
physical entity: UDP-N-acetyl-D-glucosamine
stoichiometric coefficient: 1.0

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 40

PARTICIPANT STOICHIOMETRY r1 106
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

UDP-N-acetylenolpyruvoylglucosamine reductase
type: ProteinReference
xref: uniprot Q9X239 58
organism: Thermotoga maritima

UDP-N-acetylmuramoylalanine--D-glutamate ligase
type: ProteinReference
xref: uniprot Q9RRJ4 14
organism: Deinococcus radiodurans

D-glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P18579 51
type: UnificationXref
id: P18579
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__L_glutamate-RIGHT__D_glutamate-_r5
controller: Glutamate racemase

D-alanyl-D-alanine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Glutamate racemase
type: ProteinReference
xref: uniprot Q9EX22 46
organism: Streptomyces coelicolor

uniprot Q8F1S7 44
type: UnificationXref
id: Q8F1S7
db: uniprot

uniprot Q8A806 53
type: UnificationXref
id: Q8A806
db: uniprot

uniprot P96612 79
type: UnificationXref
id: P96612
db: uniprot

D-alanine--D-alanine ligase
type: ProteinReference
xref: uniprot Q8F2R9 83
organism: Leptospira interrogans

STATE TRANSITION LEFT undecaprenyl phosphate- UDP N acetylmuramoyl L meso 2,6 diaminoheptanedioate D alanyl D alanine-RIGHT UMP- N acetyl L alanyl D glutamyl meso 2,6 diaminoheptane D alanyl D alanine diphosphoundecaprenol- r10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 113
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 112
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 114
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 111
left: UDP-N-acetylmuramoyl-L-meso-2,6-diaminoheptanedioate-D-alanyl-D-alanine
left: undecaprenyl phosphate
display name: STATE_TRANSITION_LEFT__undecaprenyl_phosphate-_UDP_N_acetylmuramoyl_L_meso_2,6_diaminoheptanedioate_D_alanyl_D_alanine-RIGHT__UMP-_N_acetyl_L_alanyl_D_glutamyl_meso_2,6_diaminoheptane_D_alanyl_D_alanine_diphosphoundecaprenol-_r10
interaction type: STATE_TRANSITION
right: UMP
right: N-acetyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptane-D-alanyl-D-alanine-diphosphoundecaprenol

N-acetylglucosamine-enoylpyruvoyl transferase
type: Protein
entity reference: N-acetylglucosamine-enoylpyruvoyl transferase
comment: SPECIES_TYPE=PROTEIN

PO4
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O66799 48
type: UnificationXref
id: O66799
db: uniprot

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
type: ProteinReference
xref: uniprot Q9RWP0 73
organism: Deinococcus radiodurans

PARTICIPANT STOICHIOMETRY r9 115
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 116
type: Stoichiometry
physical entity: D-alanyl-D-alanine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 117
type: Stoichiometry
physical entity: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 118
type: Stoichiometry
physical entity: UDP-N-acetylmuramoyl-L-meso-2,6-diaminoheptanedioate-D-alanyl-D-alanine
stoichiometric coefficient: 1.0

UDP-N-acetylmurmoyl-L-alanyl-D-glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 190304 32
type: UnificationXref
id: 190304
db: ncbitaxon

uniprot P46805 78
type: UnificationXref
id: P46805
db: uniprot

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 7

PARTICIPANT STOICHIOMETRY r9 119
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase
type: ProteinReference
xref: P03084
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Peptidoglycan biosynthesis.PROTEIN.GENERIC.UDP-N-acetylmuramoylalanyl-_br_D-glutamate 2,6-_br_diaminopimelate ligase
comment: ENTITY_REFERENCE_NOTES= Long Name: UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase Synonym: Synonym not specified Accession: P03084
member entity reference: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE homolog, chloroplastic
member entity reference: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
member entity reference: UDP-N-acetylmuramyl-tripeptide synthetase
member entity reference: Probable UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase
member entity reference: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase
member entity reference: Cyanophycin synthetase

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 32

UDP-N-acetylmuramate dehydrogenase
type: Protein
entity reference: UDP-N-acetylmuramate dehydrogenase
comment: SPECIES_TYPE=PROTEIN

UDP-N-acetylmuramoylalanine--D-glutamate ligase
type: ProteinReference
xref: uniprot Q03522 6
organism: Bacillus subtilis

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
type: ProteinReference
xref: uniprot Q03523 24
organism: Bacillus subtilis

Processive diacylglycerol beta-glucosyltransferase
type: ProteinReference
xref: uniprot P54166 64
organism: Bacillus subtilis

NADPH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r9 120
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot P17443 62
type: UnificationXref
id: P17443
db: uniprot

UDP-N-acetylmuramoylalanine-D-glutamate ligase
type: Protein
entity reference: UDP-N-acetylmuramoylalanine-D-glutamate ligase
comment: SPECIES_TYPE=PROTEIN

uniprot O66805 49
type: UnificationXref
id: O66805
db: uniprot

Glutamate racemase 2
type: ProteinReference
xref: uniprot O05412 37
organism: Bacillus subtilis

Glutamate racemase
type: ProteinReference
xref: P03087
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Glutamate racemase Synonym: Synonym not specified Accession: P03087
comment: ENTITY_REFERENCE_ID_DESC=Peptidoglycan biosynthesis.PROTEIN.GENERIC.Glutamate racemase
member entity reference: Glutamate racemase
member entity reference: Glutamate racemase 1
member entity reference: Glutamate racemase 2

D-alanine-D-alanine ligase
type: ProteinReference
xref: P03091
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Peptidoglycan biosynthesis.PROTEIN.GENERIC.D-alanine-D-_br_alanine ligase
comment: ENTITY_REFERENCE_NOTES= Long Name: D-alanine-D-alanine ligase Synonym: Synonym not specified Accession: P03091
member entity reference: D-alanine--D-alanine ligase
member entity reference: Probable D-alanine-D-alanine ligase
member entity reference: D-alanine--D-alanine ligase B

meso-diaminopimelate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__ATP-_2_D_alanine-RIGHT__PO4-_D_alanyl_D_alanine-_ADP-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 123
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 121
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 122
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 124
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 125
left: 2 D-alanine
left: ATP
interaction type: STATE_TRANSITION
right: PO4
right: ADP
right: D-alanyl-D-alanine

UDP-N-acetylenolpyruvoylglucosamine reductase
type: ProteinReference
xref: uniprot Q9RWN8 57
organism: Deinococcus radiodurans

uniprot Q8A258 67
type: UnificationXref
id: Q8A258
db: uniprot

Glutamate racemase
type: ProteinReference
xref: uniprot O66662 38
organism: Aquifex aeolicus

UDP-N-acetymuramate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

UDP-N-acetylmuramoylalanine--D-glutamate ligase
type: ProteinReference
xref: uniprot Q8F7V4 12
organism: Leptospira interrogans

uniprot Q8A256 10
type: UnificationXref
id: Q8A256
db: uniprot

D-alanine--D-alanine ligase
type: ProteinReference
xref: uniprot O66806 76
organism: Aquifex aeolicus

uniprot P37585 63
type: UnificationXref
id: P37585
db: uniprot

UDP-N-acetylenolpyruvoylglucosamine reductase
type: ProteinReference
xref: uniprot O66805 49
organism: Aquifex aeolicus

PARTICIPANT STOICHIOMETRY r3 96
type: Stoichiometry
physical entity: UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
stoichiometric coefficient: 1.0

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
type: ProteinReference
xref: uniprot Q7NFN2 26
organism: Gloeobacter violaceus

PARTICIPANT STOICHIOMETRY r3 97
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 98
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

uniprot Q8RDQ3 55
type: UnificationXref
id: Q8RDQ3
db: uniprot

P03090
type: UnificationXref
id: P03090
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r3 99
type: Stoichiometry
physical entity: UDP-N-acetymuramate
stoichiometric coefficient: 1.0

P03091
type: UnificationXref
id: P03091
db: PANTHER Pathway Component

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 3

uniprot Q8F7V4 12
type: UnificationXref
id: Q8F7V4
db: uniprot

STATE_TRANSITION_LEFT__UDP_N_acetyl_3__1_carboxyvinyl__D_glucosamine-_NADPH-RIGHT__NADP-_UDP_N_acetymuramate-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 99
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 97
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 98
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 96
left: NADPH
left: UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
interaction type: STATE_TRANSITION
right: NADP
right: UDP-N-acetymuramate

uniprot O66662 38
type: UnificationXref
id: O66662
db: uniprot

D-alanine--D-alanine ligase B
type: ProteinReference
xref: uniprot P07862 77
organism: Escherichia coli

UDP-N-acetyl-D-glucosamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P54166 64
type: UnificationXref
id: P54166
db: uniprot

uniprot Q8A254 29
type: UnificationXref
id: Q8A254
db: uniprot

uniprot Q8REE6 45
type: UnificationXref
id: Q8REE6
db: uniprot

P03087
type: UnificationXref
id: P03087
db: PANTHER Pathway Component

P03088
type: UnificationXref
id: P03088
db: PANTHER Pathway Component

uniprot Q03523 24
type: UnificationXref
id: Q03523
db: uniprot

uniprot Q8A1F3 82
type: UnificationXref
id: Q8A1F3
db: uniprot

P03083
type: UnificationXref
id: P03083
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_2_D_alanine-RIGHT__PO4-_D_alanyl_D_alanine-_ADP-_r8
controller: D-alanine-D-alanine ligase

D-alanine--D-alanine ligase
type: ProteinReference
xref: uniprot Q9RXF1 86
organism: Deinococcus radiodurans

P03084
type: UnificationXref
id: P03084
db: PANTHER Pathway Component

P03085
type: UnificationXref
id: P03085
db: PANTHER Pathway Component

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
type: ProteinReference
xref: uniprot Q8R635 31
organism: Fusobacterium nucleatum

uniprot P22634 39
type: UnificationXref
id: P22634
db: uniprot

uniprot Q9RWP0 73
type: UnificationXref
id: Q9RWP0
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_UDP_N_acetylmuramoyl_alanine-_D_glutamate-RIGHT__UDP_N_acetylmurmoyl_L_alanyl_D_glutamate-_PO4-_ADP-_r7
controller: UDP-N-acetylmuramoylalanine-D-glutamate ligase

Cyanophycin synthetase
type: ProteinReference
xref: uniprot Q7NDB0 25
organism: Gloeobacter violaceus

uniprot Q8F2R9 83
type: UnificationXref
id: Q8F2R9
db: uniprot

N-Acetylglucosaminyl transferase
type: ProteinReference
xref: P03090
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: N-Acetylglucosaminyl transferase Synonym: Synonym not specified Accession: P03090
comment: ENTITY_REFERENCE_ID_DESC=Peptidoglycan biosynthesis.PROTEIN.GENERIC.N-Acetylglucosaminyl_br_transferase
member entity reference: UDP-3-O-acyl-N-acetylglucosamine deacetylase
member entity reference: UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
member entity reference: Glr3229 protein
member entity reference: Glycosyltransferase
member entity reference: Uncharacterized glycosyltransferase YkoN
member entity reference: Processive diacylglycerol beta-glucosyltransferase
member entity reference: Cell wall synthesis protein, putative
member entity reference: Uncharacterized protein

STATE_TRANSITION_LEFT__ATP-_UDP_N_acetylmuramoyl_alanine-_D_glutamate-RIGHT__UDP_N_acetylmurmoyl_L_alanyl_D_glutamate-_PO4-_ADP-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 127
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 130
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 126
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 131
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 129
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 128
left: D-glutamate
left: ATP
left: UDP-N-acetylmuramoyl-alanine
interaction type: STATE_TRANSITION
right: PO4
right: ADP
right: UDP-N-acetylmurmoyl-L-alanyl-D-glutamate

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 28

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
type: ProteinReference
xref: uniprot P17443 62
organism: Escherichia coli

uniprot Q9ZBA5 75
type: UnificationXref
id: Q9ZBA5
db: uniprot

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 17

D-alanine-D-alanine ligase
type: Protein
entity reference: D-alanine-D-alanine ligase
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r2 103
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

Glutamate racemase
type: ProteinReference
xref: uniprot P22634 39
organism: Escherichia coli

UDP-N-acetylmuramoyl-L-meso-2,6-diaminoheptanedioate-D-alanyl-D-alanine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9ZBR9 87
type: UnificationXref
id: Q9ZBR9
db: uniprot

PARTICIPANT STOICHIOMETRY r2 100
type: Stoichiometry
physical entity: phosphoenolpyruvate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 101
type: Stoichiometry
physical entity: UDP-N-acetyl-D-glucosamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 102
type: Stoichiometry
physical entity: UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
stoichiometric coefficient: 1.0

uniprot O67238 60
type: UnificationXref
id: O67238
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

uniprot O84271 23
type: UnificationXref
id: O84271
db: uniprot

uniprot Q9RVF3 72
type: UnificationXref
id: Q9RVF3
db: uniprot

uniprot Q9L0L7 56
type: UnificationXref
id: Q9L0L7
db: uniprot

N-acetyl-glucosamine-1-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9S2W7 34
type: UnificationXref
id: Q9S2W7
db: uniprot

L-glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O05412 37
type: UnificationXref
id: O05412
db: uniprot

uniprot Q03522 6
type: UnificationXref
id: Q03522
db: uniprot

PARTICIPANT STOICHIOMETRY r11 110
type: Stoichiometry
physical entity: UDP-undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)-N-acetylglucosamine
stoichiometric coefficient: 1.0

Phospho-N-acetylmuramoyl pentapeptide transferase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q7NEZ5 8
type: UnificationXref
id: Q7NEZ5
db: uniprot

Glutamate racemase
type: ProteinReference
xref: uniprot Q9RU10 47
organism: Deinococcus radiodurans

PARTICIPANT STOICHIOMETRY r10 113
type: Stoichiometry
physical entity: UMP
stoichiometric coefficient: 1.0

UTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r10 114
type: Stoichiometry
physical entity: N-acetyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptane-D-alanyl-D-alanine-diphosphoundecaprenol
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 111
type: Stoichiometry
physical entity: undecaprenyl phosphate
stoichiometric coefficient: 1.0

uniprot F4I3P9 20
type: UnificationXref
id: F4I3P9
db: uniprot

PARTICIPANT STOICHIOMETRY r10 112
type: Stoichiometry
physical entity: UDP-N-acetylmuramoyl-L-meso-2,6-diaminoheptanedioate-D-alanyl-D-alanine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 108
type: Stoichiometry
physical entity: UDP-N-acetyl-glucosamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 109
type: Stoichiometry
physical entity: N-acetyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptane-D-alanyl-D-alanine-diphosphoundecaprenol
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__L_glutamate-RIGHT__D_glutamate-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 89
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 88
left: L-glutamate
interaction type: STATE_TRANSITION
right: D-glutamate

ncbitaxon 3702 21
type: UnificationXref
id: 3702
db: ncbitaxon

ncbitaxon 243230 15
type: UnificationXref
id: 243230
db: ncbitaxon

uniprot Q9RRJ4 14
type: UnificationXref
id: Q9RRJ4
db: uniprot

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
type: ProteinReference
xref: uniprot O67238 60
organism: Aquifex aeolicus

UDP-N-acetylmuramoylalanine--D-glutamate ligase
type: ProteinReference
xref: uniprot O67852 2
organism: Aquifex aeolicus

uniprot Q8R635 31
type: UnificationXref
id: Q8R635
db: uniprot

UDP-N-acetylenolpyruvoylglucosamine reductase
type: ProteinReference
xref: uniprot O66799 48
organism: Aquifex aeolicus

PANTHER Pathway P02763 1
type: UnificationXref
id: P02763
db: PANTHER Pathway

uniprot O67852 2
type: UnificationXref
id: O67852
db: uniprot

uniprot Q9RXF1 86
type: UnificationXref
id: Q9RXF1
db: uniprot

phosphoenolpyruvate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r8 122
type: Stoichiometry
physical entity: 2 D-alanine
stoichiometric coefficient: 1.0

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
type: ProteinReference
xref: uniprot O67631 22
organism: Aquifex aeolicus

uniprot P94556 41
type: UnificationXref
id: P94556
db: uniprot

PARTICIPANT STOICHIOMETRY r8 121
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

UDP-N-acetylenolpyruvoylglucosamine reductase
type: ProteinReference
xref: uniprot Q9L0L7 56
organism: Streptomyces coelicolor

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
type: ProteinReference
xref: uniprot P37585 63
organism: Bacillus subtilis

Glycosyltransferase
type: ProteinReference
xref: uniprot Q9C9T8 70
organism: Arabidopsis thaliana

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__UDP_N_acetyl_3__1_carboxyvinyl__D_glucosamine-_NADPH-RIGHT__NADP-_UDP_N_acetymuramate-_r3
controller: UDP-N-acetylmuramate dehydrogenase

uniprot Q9RU10 47
type: UnificationXref
id: Q9RU10
db: uniprot

PARTICIPANT STOICHIOMETRY r8 125
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q7NFN2 26
type: UnificationXref
id: Q7NFN2
db: uniprot

PARTICIPANT STOICHIOMETRY r8 124
type: Stoichiometry
physical entity: D-alanyl-D-alanine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 123
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

uniprot P0CD77 50
type: UnificationXref
id: P0CD77
db: uniprot

UDP-N-acetylmuramoylalanine--D-glutamate ligase
type: ProteinReference
xref: uniprot O84763 4
organism: Chlamydia trachomatis

STATE TRANSITION LEFT ATP- D alanyl D alanine- UDP N acetylmuramoyl L alanyl D glutamyl meso 2,6 diaminoheptanedioate-RIGHT UDP N acetylmuramoyl L meso 2,6 diaminoheptanedioate D alanyl D alanine- PO4- ADP- r9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 115
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 119
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 118
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 117
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 120
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 116
left: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate
left: ATP
left: D-alanyl-D-alanine
display name: STATE_TRANSITION_LEFT__ATP-_D_alanyl_D_alanine-_UDP_N_acetylmuramoyl_L_alanyl_D_glutamyl_meso_2,6_diaminoheptanedioate-RIGHT__UDP_N_acetylmuramoyl_L_meso_2,6_diaminoheptanedioate_D_alanyl_D_alanine-_PO4-_ADP-_r9
interaction type: STATE_TRANSITION
right: UDP-N-acetylmuramoyl-L-meso-2,6-diaminoheptanedioate-D-alanyl-D-alanine
right: PO4
right: ADP

uniprot Q9WXW3 36
type: UnificationXref
id: Q9WXW3
db: uniprot

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
type: ProteinReference
xref: uniprot O84766 61
organism: Chlamydia trachomatis

UDP-N-acetylmuramoylalanine--D-glutamate ligase
type: ProteinReference
xref: uniprot Q7NEZ5 8
organism: Gloeobacter violaceus

uniprot P07862 77
type: UnificationXref
id: P07862
db: uniprot

ncbitaxon 83333 40
type: UnificationXref
id: 83333
db: ncbitaxon

UDP-N-acetylenolpyruvoylglucosamine reductase
type: ProteinReference
xref: uniprot Q8A806 53
organism: Bacteroides thetaiotaomicron

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
type: ProteinReference
xref: uniprot O84271 23
organism: Chlamydia trachomatis

UDP-N-acetylmuramoyl-alanine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

N-acetylglucosamine-enoylpyruvoyl transferase
type: ProteinReference
xref: P03085
comment: ENTITY_REFERENCE_ID_DESC=Peptidoglycan biosynthesis.PROTEIN.GENERIC.N-acetylglucosamine-_br_enoylpyruvoyl transferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: N-acetylglucosamine-enoylpyruvoyl transferase Synonym: Synonym not specified Accession: P03085
member entity reference: UDP-N-acetylglucosamine 1-carboxyvinyltransferase