3-Hydroxyacyl-CoA-dehydrogenase
type: Protein
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__phenylacetate-_CoA-_ATP-RIGHT__AMP-_phenylacetyl_CoA-_PPi-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 15
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 12
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 11
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 14
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 13
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 10
left: ATP
left: CoA
left: phenylacetate
interaction type: STATE_TRANSITION
right: phenylacetyl-CoA
right: AMP
right: PPi

NADPH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

NADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__CoA-_ketoadipyl_CoA-RIGHT__acetyl_CoA-_succinyl_CoA-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 18
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 17
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 19
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 16
left: ketoadipyl-CoA
left: CoA
interaction type: STATE_TRANSITION
right: succinyl-CoA
right: acetyl-CoA

PARTICIPANT STOICHIOMETRY r4 23
type: Stoichiometry
physical entity: ketoadipyl-CoA
stoichiometric coefficient: 1.0

PANTHER Pathway P02764 1
type: UnificationXref
id: P02764
db: PANTHER Pathway

phenylacetate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Enoyl-CoA dehydratase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r2 8
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CoA-_cis_dihydrodiol_phenylacetyl_CoA-_H2O-RIGHT__acetyl_CoA-_3_hydroxyadipyl_CoA-_r3
controller: Enoyl-CoA dehydratase

PARTICIPANT STOICHIOMETRY r2 7
type: Stoichiometry
physical entity: phenylacetyl-CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 9
type: Stoichiometry
physical entity: cis-dihydrodiol phenylacetyl-CoA
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: InteractionVocabulary

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION_LEFT__CoA-_cis_dihydrodiol_phenylacetyl_CoA-_H2O-RIGHT__acetyl_CoA-_3_hydroxyadipyl_CoA-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 3
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 4
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 6
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 5
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 2
left: cis-dihydrodiol phenylacetyl-CoA
left: CoA
left: H2O
interaction type: STATE_TRANSITION
right: 3-hydroxyadipyl-CoA
right: acetyl-CoA

Phenylacetate-CoA oxygenase
type: Protein
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__phenylacetyl_CoA-_O2-RIGHT__cis_dihydrodiol_phenylacetyl_CoA-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 8
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 9
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 7
left: phenylacetyl-CoA
left: O2
interaction type: STATE_TRANSITION
right: cis-dihydrodiol phenylacetyl-CoA

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CoA-_ketoadipyl_CoA-RIGHT__acetyl_CoA-_succinyl_CoA-_r5
controller: Ketothiolase

ketoadipyl-CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phenylacetate-_CoA-_ATP-RIGHT__AMP-_phenylacetyl_CoA-_PPi-_r1
controller: Phenylacetate-CoA ligase

STATE_TRANSITION_LEFT__3_hydroxyadipyl_CoA-_NADP-RIGHT__NADPH-_ketoadipyl_CoA-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 20
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 22
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 23
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 21
left: NADP
left: 3-hydroxyadipyl-CoA
interaction type: STATE_TRANSITION
right: ketoadipyl-CoA
right: NADPH

cis-dihydrodiol phenylacetyl-CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Phenylacetate degradation
type: Pathway
pathway component: STATE_TRANSITION_LEFT__CoA-_ketoadipyl_CoA-RIGHT__acetyl_CoA-_succinyl_CoA-_r5
pathway component: STATE_TRANSITION_LEFT__phenylacetate-_CoA-_ATP-RIGHT__AMP-_phenylacetyl_CoA-_PPi-_r1
pathway component: STATE_TRANSITION_LEFT__phenylacetyl_CoA-_O2-RIGHT__cis_dihydrodiol_phenylacetyl_CoA-_r2
pathway component: STATE_TRANSITION_LEFT__CoA-_cis_dihydrodiol_phenylacetyl_CoA-_H2O-RIGHT__acetyl_CoA-_3_hydroxyadipyl_CoA-_r3
pathway component: STATE_TRANSITION_LEFT__3_hydroxyadipyl_CoA-_NADP-RIGHT__NADPH-_ketoadipyl_CoA-_r4
xref: PANTHER Pathway P02764 1
comment: MODEL_NOTES= Phenylacetate degradation is the breakdown of the phenylacetate to succinyl-CoA as a source of energy production. Website=http://www.biocyc.org/Ecoli/Pathways/ free text=Voet and Voet (Textbook) Biochemistry

Phenylacetate-CoA ligase
type: Protein
comment: SPECIES_TYPE=PROTEIN

O2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

acetyl-CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r1 15
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 13
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 14
type: Stoichiometry
physical entity: phenylacetyl-CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 11
type: Stoichiometry
physical entity: CoA
stoichiometric coefficient: 1.0

PPi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r1 12
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

AMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r1 10
type: Stoichiometry
physical entity: phenylacetate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 22
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 6
type: Stoichiometry
physical entity: 3-hydroxyadipyl-CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 21
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 20
type: Stoichiometry
physical entity: 3-hydroxyadipyl-CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 4
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 5
type: Stoichiometry
physical entity: acetyl-CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 2
type: Stoichiometry
physical entity: CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 3
type: Stoichiometry
physical entity: cis-dihydrodiol phenylacetyl-CoA
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__3_hydroxyadipyl_CoA-_NADP-RIGHT__NADPH-_ketoadipyl_CoA-_r4
controller: 3-Hydroxyacyl-CoA-dehydrogenase

Ketothiolase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r5 16
type: Stoichiometry
physical entity: CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 19
type: Stoichiometry
physical entity: succinyl-CoA
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phenylacetyl_CoA-_O2-RIGHT__cis_dihydrodiol_phenylacetyl_CoA-_r2
controller: Phenylacetate-CoA oxygenase

PARTICIPANT STOICHIOMETRY r5 17
type: Stoichiometry
physical entity: ketoadipyl-CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 18
type: Stoichiometry
physical entity: acetyl-CoA
stoichiometric coefficient: 1.0

3-hydroxyadipyl-CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

succinyl-CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

phenylacetyl-CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE