tPA
type: Protein
entity reference: tPA
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa20 113
comment: SPECIES_TYPE=PROTEIN

alpha2 antiplasmin
type: ProteinReference
xref: P01264
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC._alpha_2_space_antiplasmin
comment: ENTITY_REFERENCE_NOTES= Long Name: alpha2 antiplasmin Synonym: alpha_2 antiplasmin,alpha_2-PI,plasmin inhibitor alpha_2,serine protease inhibitor F2 Accession: P01264
member entity reference: Alpha-2-antiplasmin
member entity reference: Uncharacterized protein

uniprot F1MW26 56
type: UnificationXref
id: F1MW26
db: uniprot

uPA s16 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: uPA
stoichiometric coefficient: 1.0

eco ECO:0000270 70
type: UnificationXref
id: ECO:0000270
db: eco

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Fibrin-RIGHT__Fibrin_C_terminal_truncation-_r16
control type: INHIBITION
controller: TAFI

uniprot F6UZ20 81
type: UnificationXref
id: F6UZ20
db: uniprot

Collagenase 3
type: ProteinReference
xref: PTHR10201:SF165
xref: uniprot G3V742 62
organism: Rattus norvegicus

Urokinase-type plasminogen activator
type: ProteinReference
xref: uniprot P29598 16
organism: Rattus norvegicus

uPA s20 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: uPA
stoichiometric coefficient: 1.0

TRUNCATION_LEFT__pro_tPA-RIGHT__tPA-_?-_r34
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 148
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 147
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 146
left: pro-tPA
interaction type: TRUNCATION
right: tPA
right: ?

Fibrinogen beta chain
type: ProteinReference
xref: uniprot F1NUL9 80
organism: Gallus gallus

uniprot Q8VCM7 94
type: UnificationXref
id: Q8VCM7
db: uniprot

PTHR11461:SF49
type: RelationshipXref
id: PTHR11461:SF49
db: PANTHER Family
relationship type: By Homology

uniprot F6UZ87 82
type: UnificationXref
id: F6UZ87
db: uniprot

Plasmin
type: Protein
entity reference: Plasmin
feature: ACTIVE 41
comment: SPECIES_TYPE=PROTEIN

Plasminogen
type: ProteinReference
xref: uniprot E1B726 34
xref: PTHR24261:SF13
organism: Bos taurus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 12

uniprot P28800 102
type: UnificationXref
id: P28800
db: uniprot

Fibrin
type: Protein
entity reference: Fibrin
feature: ACTIVE 41
comment: SPECIES_TYPE=PROTEIN

uPAR
type: Protein
entity reference: uPAR
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa13 133
cellular location: epithelial cell c2
comment: SPECIES_TYPE=PROTEIN

uPAR s10 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: uPAR
stoichiometric coefficient: 1.0

pro-MMP-9
type: Protein
entity reference: pro-MMP-9
comment: SPECIES_TYPE=PROTEIN

uniprot P14448 91
type: UnificationXref
id: P14448
db: uniprot

uniprot Q8K0E8 93
type: UnificationXref
id: Q8K0E8
db: uniprot

PTHR10624:SF6
type: RelationshipXref
id: PTHR10624:SF6
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__Plasmin-_alpha2_antiplasmin-RIGHT__Complex__Plasmin_alpha2_antiplasmin_-_r15
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 172
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 170
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 171
left: alpha2 antiplasmin
left: Plasmin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Plasmin/alpha2 antiplasmin)

Uncharacterized protein
type: ProteinReference
xref: PTHR24264:SF38
xref: uniprot F6YDX7 3
organism: Macaca mulatta

uniprot Q05588 98
type: UnificationXref
id: Q05588
db: uniprot

ncbitaxon 9544 4
type: UnificationXref
id: 9544
db: ncbitaxon

eco ECO:0000501 97
type: UnificationXref
id: ECO:0000501
db: eco

Plasmin s1 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Plasmin
stoichiometric coefficient: 1.0

ncbitaxon 9606 10
type: UnificationXref
id: 9606
db: ncbitaxon

eco ECO:0000250 5
type: UnificationXref
id: ECO:0000250
db: eco

PAI-1
type: Protein
entity reference: PAI-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa19 111
comment: SPECIES_TYPE=PROTEIN

MMP-1
type: ProteinReference
xref: P01252
standard name: Matrix metalloprotease 1
comment: ENTITY_REFERENCE_NOTES= Long Name: Matrix metalloprotease 1 Synonym: Collagenase,Fibroblast Collagenase,Interstitial Collagenase,MMP-1,Matrix metalloproteinase 1 Accession: P01252
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.MMP_minus_1
member entity reference: MMP1 isoform 1
member entity reference: Interstitial collagenase
member entity reference: Uncharacterized protein

PTHR11461:SF61
type: RelationshipXref
id: PTHR11461:SF61
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r16 168
type: Stoichiometry
physical entity: Fibrin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r16 169
type: Stoichiometry
physical entity: Fibrin C-terminal truncation
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Complex__GPI_linker_uPAR__pro_uPA_-RIGHT__?-_Complex__GPI_linker_uPAR__uPA_-_r33
controller: Plasmin

Fibrin
type: ProteinReference
xref: P01253
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.Fibrin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Fibrin Synonym: Fibrin degradation products Accession: P01253
member entity reference: Fibrinogen beta chain
member entity reference: FGA isoform 1
member entity reference: Fgb protein
member entity reference: Fibrinogen alpha chain
member entity reference: Fibrinogen gamma chain
member entity reference: Fibrinogen gamma-B chain
member entity reference: Uncharacterized protein
member entity reference: FGB isoform 1
member entity reference: FGG isoform 5

uPAR s4 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: uPAR
stoichiometric coefficient: 1.0

uPA
type: Protein
entity reference: uPA
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa5 109
cellular location: epithelial cell c2
comment: SPECIES_TYPE=PROTEIN

uniprot P05121 31
type: UnificationXref
id: P05121
db: uniprot

Stromelysin-1
type: ProteinReference
xref: PTHR10201:SF215
xref: uniprot P08254 71
organism: Homo sapiens

uniprot F7HQV3 42
type: UnificationXref
id: F7HQV3
db: uniprot

GPI linker s6 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GPI linker
stoichiometric coefficient: 1.0

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 8

pro-tPA
type: Protein
entity reference: pro-tPA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Tissue-type plasminogen activator
type: ProteinReference
xref: PTHR24264:SF42
xref: uniprot P19637 52
organism: Rattus norvegicus

uniprot P11214 51
type: UnificationXref
id: P11214
db: uniprot

Plasminogen activating cascade
type: Pathway
pathway component: TRUNCATION_LEFT__Fibrin-_Plasminogen-RIGHT__?-_Plasmin-_r32
pathway component: HETERODIMER_ASSOCIATION_LEFT__PAI_1-_tPA-RIGHT__Complex__PAI_1_tPA_-_r26
pathway component: TRUNCATION_LEFT__pro_MMP_1-RIGHT__?-_MMP_1-_r27
pathway component: TRUNCATION_LEFT__pro_MMP_9-RIGHT__?-_MMP_9-_r28
pathway component: TRANSPORT_LEFT__pro_MMP_1-RIGHT__pro_MMP_1-_r17
pathway component: HETERODIMER_ASSOCIATION_LEFT__Plasmin-_alpha2_antiplasmin-RIGHT__Complex__Plasmin_alpha2_antiplasmin_-_r15
pathway component: TRUNCATION_LEFT__Complex__GPI_linker_uPAR__pro_uPA_-RIGHT__?-_Complex__GPI_linker_uPAR__uPA_-_r33
pathway component: STATE_TRANSITION_LEFT__Fibrin-RIGHT__Fibrin_C_terminal_truncation-_r16
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__GPI_linker_uPAR__uPA_-_PAI_1-RIGHT__Complex__uPAR_GPI_linker__uPA_PAI_1_-_r6
pathway component: TRANSPORT_LEFT__pro_MMP_9-RIGHT__pro_MMP_9-_r18
pathway component: TRUNCATION_LEFT__pro_tPA-RIGHT__tPA-_?-_r34
pathway component: TRANSPORT_LEFT__tPA-RIGHT__tPA-_r14
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__uPAR_GPI_linker_-_pro_uPA-RIGHT__Complex__GPI_linker_uPAR__pro_uPA_-_r2
pathway component: TRANSPORT_LEFT__pro_MMP_3-RIGHT__pro_MMP_3-_r19
pathway component: TRANSPORT_LEFT__pro_MMP_13-RIGHT__pro_MMP_13-_r22
pathway component: HETERODIMER_ASSOCIATION_LEFT__PAI_2-_Complex__GPI_linker_uPAR__uPA_-RIGHT__Complex__GPI_linker_uPAR__uPA_PAI_2_-_r23
pathway component: TRUNCATION_LEFT__pro_MMP_3-RIGHT__?-_MMP_3-_r30
pathway component: TRUNCATION_LEFT__pro_MMP_13-RIGHT__MMP_13-_?-_r31
pathway component: STATE_TRANSITION_LEFT__Thrombus__fibrin_clot_-RIGHT__Fibrin-_r12
xref: PANTHER Pathway P00050 1
comment: MODEL_NOTES=Panther Pathway: P00050 The plasminogen activation cascade is a serine protease cascade in which the inactive zymogen plasminogen is converted into plasmin. Plasmin's primary function is thought to be the dissolution of blood clots. Plasmin is also thought to act as a proteolytic activator of other processes including tissue remodeling through its activation of the matrix metalloproteases. Medline=11382594 OMIM=173350 PMID: 11382594

PTHR10201:SF30
type: RelationshipXref
id: PTHR10201:SF30
db: PANTHER Family
relationship type: By Homology

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 61

PARTICIPANT STOICHIOMETRY r34 148
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r34 147
type: Stoichiometry
physical entity: tPA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r34 146
type: Stoichiometry
physical entity: pro-tPA
stoichiometric coefficient: 1.0

pro-MMP-1
type: ProteinReference
xref: P01263
standard name: pro-Matrix metalloprotease 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.pro_minus_MMP_minus_1
comment: ENTITY_REFERENCE_NOTES= Long Name: pro-Matrix metalloprotease 1 Synonym: pro-Collagenase,pro-Fibroblast Collagenase,pro-Interstitial Collagenase,pro-Matrix metalloproteinase 1 Accession: P01263
member entity reference: MMP1 isoform 1
member entity reference: Interstitial collagenase
member entity reference: Uncharacterized protein

uniprot E1BV78 79
type: UnificationXref
id: E1BV78
db: uniprot

TRUNCATION_LEFT__pro_MMP_13-RIGHT__MMP_13-_?-_r31
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 157
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 158
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 156
left: pro-MMP-13
interaction type: TRUNCATION
right: ?
right: MMP-13

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

PARTICIPANT STOICHIOMETRY r6 177
type: Stoichiometry
physical entity: Complex (uPAR/GPI linker/ uPA/PAI-1)
stoichiometric coefficient: 1.0

uniprot P22777 33
type: UnificationXref
id: P22777
db: uniprot

PARTICIPANT STOICHIOMETRY r6 176
type: Stoichiometry
physical entity: PAI-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 175
type: Stoichiometry
physical entity: Complex (GPI linker/uPAR/ uPA)
stoichiometric coefficient: 1.0

PAI 2 s200 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PAI-2
stoichiometric coefficient: 1.0

uPAR
type: Protein
entity reference: uPAR
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa1 141
cellular location: epithelial cell c2
comment: SPECIES_TYPE=PROTEIN

Complex (uPAR/GPI linker)
type: Complex
component stoichiometry: GPI linker s5 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: uPAR s4 sa1 STOICHIOMETRY ID COMPLEX
component: GPI linker
component: uPAR
feature: COMPLEX BINDING FEATURE s15 a27 142
feature: COMPLEX BINDING FEATURE s15 a27 140
cellular location: epithelial cell c2

uniprot F6YVN6 67
type: UnificationXref
id: F6YVN6
db: uniprot

uniprot P12799 90
type: UnificationXref
id: P12799
db: uniprot

TRANSPORT_LEFT__pro_MMP_3-RIGHT__pro_MMP_3-_r19
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 162
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 163
left: pro-MMP-3
interaction type: TRANSPORT
right: pro-MMP-3

Fibrinogen alpha chain
type: ProteinReference
xref: uniprot P14448 91
xref: PTHR19143:SF232
organism: Gallus gallus

MMP1 isoform 1
type: ProteinReference
xref: uniprot H2Q4N3 74
xref: PTHR10201:SF151
organism: Pan troglodytes

MMP3 isoform 1
type: ProteinReference
xref: uniprot H2Q4N2 68
xref: PTHR10201:SF215
organism: Pan troglodytes

pro-MMP-3
type: Protein
entity reference: pro-MMP-3
cellular location: fibroblast c4
comment: SPECIES_TYPE=PROTEIN

uniprot Q05589 18
type: UnificationXref
id: Q05589
db: uniprot

Stromelysin-1
type: ProteinReference
xref: PTHR10201:SF215
xref: uniprot P03957 69
organism: Rattus norvegicus

Interstitial collagenase
type: ProteinReference
xref: PTHR10201:SF151
xref: uniprot P03956 75
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r32 155
type: Stoichiometry
physical entity: Plasmin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r32 154
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

uniprot P29598 16
type: UnificationXref
id: P29598
db: uniprot

Fibrinogen beta chain
type: ProteinReference
xref: PTHR19143:SF332
xref: uniprot Q8K0E8 93
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r32 153
type: Stoichiometry
physical entity: Plasminogen
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r32 152
type: Stoichiometry
physical entity: Fibrin
stoichiometric coefficient: 1.0

Tissue-type plasminogen activator
type: ProteinReference
xref: uniprot P11214 51
xref: PTHR24264:SF42
organism: Mus musculus

uniprot P14780 99
type: UnificationXref
id: P14780
db: uniprot

Neutrophil collagenase
type: ProteinReference
xref: PTHR10201:SF137
xref: uniprot O70138 63
organism: Mus musculus

pro-MMP-13
type: ProteinReference
xref: P01254
standard name: pro-matrix metalloprotease 13
comment: ENTITY_REFERENCE_NOTES= Long Name: pro-matrix metalloprotease 13 Synonym: pro-Collagenase 3,pro-Matrix metalloproteinase 13 Accession: P01254
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.pro_minus_MMP_minus_13
member entity reference: Matrix metallopeptidase 13
member entity reference: Collagenase 3
member entity reference: Neutrophil collagenase
member entity reference: Matrix metallopeptidase 13 (collagenase 3)-like
member entity reference: Uncharacterized protein

MMP-13
type: Protein
entity reference: MMP-13
feature: ACTIVE 41
comment: SPECIES_TYPE=PROTEIN

uniprot P02676 87
type: UnificationXref
id: P02676
db: uniprot

MMP-1
type: Protein
entity reference: MMP-1
feature: ACTIVE 41
comment: SPECIES_TYPE=PROTEIN

TRUNCATION
type: RelationshipTypeVocabulary

Serpin family E member 1
type: ProteinReference
xref: PTHR11461:SF49
xref: uniprot A0A452DIJ9 26
organism: Bos taurus

pro uPA s8 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: pro-uPA
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Thrombus__fibrin_clot_-RIGHT__Fibrin-_r12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 178
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 179
left: Thrombus (fibrin clot)
interaction type: STATE_TRANSITION
right: Fibrin

uniprot P28053 76
type: UnificationXref
id: P28053
db: uniprot

By Homology
type: RelationshipTypeVocabulary

Complex (GPI linker/uPAR/ pro-uPA)
type: Complex
component stoichiometry: pro uPA s8 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: GPI linker s6 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: uPAR s7 sa13 STOICHIOMETRY ID COMPLEX
component: GPI linker
component: uPAR
component: pro-uPA
feature: COMPLEX BINDING FEATURE s11 a21 132
feature: COMPLEX BINDING FEATURE s11 a21 134
feature: COMPLEX BINDING FEATURE s11 a21 130
cellular location: epithelial cell c2

Uncharacterized protein
type: ProteinReference
xref: PTHR19143:SF332
xref: uniprot F6UZ87 82
organism: Macaca mulatta

alpha2 antiplasmin s2 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha2 antiplasmin
stoichiometric coefficient: 1.0

fibroblast c4
type: CellularLocationVocabulary
comment: fibroblast

SERPINE1 isoform 1
type: ProteinReference
xref: PTHR11461:SF49
xref: uniprot H2QV47 30
organism: Pan troglodytes

Carboxypeptidase B2
type: ProteinReference
xref: PTHR11705:SF17
xref: uniprot Q9EQV9 45
organism: Rattus norvegicus

PTHR10201:SF137
type: RelationshipXref
id: PTHR10201:SF137
db: PANTHER Family
relationship type: By Homology

Plasminogen activator inhibitor 1
type: ProteinReference
xref: PTHR11461:SF49
xref: uniprot P20961 32
organism: Rattus norvegicus

Plasminogen
type: ProteinReference
xref: uniprot H2QU06 36
xref: PTHR24261:SF13
organism: Pan troglodytes

Fibrin C-terminal truncation
type: Protein
entity reference: Fibrin C-terminal truncation
comment: SPECIES_TYPE=PROTEIN

uniprot F6YDX7 3
type: UnificationXref
id: F6YDX7
db: uniprot

pro-uPA
type: ProteinReference
xref: P01262
standard name: pro-urokinase type plasminogen activator
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: pro-urokinase type plasminogen activator Synonym: pro plasminogen activator, urinary,pro-PLAU,pro-urokinase,pro-urokinase plasminogen activator Accession: P01262
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.pro_minus_uPA
member entity reference: Uncharacterized protein
member entity reference: Urokinase-type plasminogen activator
member entity reference: PLAU isoform 1

Fibrinogen gamma-B chain
type: ProteinReference
xref: uniprot P12799 90
xref: PTHR19143:SF338
organism: Bos taurus

PTHR11705:SF17
type: RelationshipXref
id: PTHR11705:SF17
db: PANTHER Family
relationship type: By Homology

uPAR
type: Protein
entity reference: uPAR
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa6 123
cellular location: epithelial cell c2
comment: SPECIES_TYPE=PROTEIN

uniprot P20918 39
type: UnificationXref
id: P20918
db: uniprot

TRANSPORT_LEFT__pro_MMP_13-RIGHT__pro_MMP_13-_r22
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 145
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 144
left: pro-MMP-13
interaction type: TRANSPORT
right: pro-MMP-13

uniprot Q61247 103
type: UnificationXref
id: Q61247
db: uniprot

PAI-1
type: Protein
entity reference: PAI-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa9 129
cellular location: epithelial cell c2
comment: SPECIES_TYPE=PROTEIN

Plasmin
type: Protein
entity reference: Plasmin
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa10 137
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__pro_MMP_3-RIGHT__?-_MMP_3-_r30
controller: Plasmin

Bos taurus
type: BioSource
xref: ncbitaxon 9913 19

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 4

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 97

uniprot F1PUI4 27
type: UnificationXref
id: F1PUI4
db: uniprot

GPI linker
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa15 115
cellular location: epithelial cell c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PAI-2
type: Protein
entity reference: PAI-2
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3T2M5 77
type: UnificationXref
id: A0A2I3T2M5
db: uniprot

Plasminogen
type: ProteinReference
xref: uniprot Q01177 40
xref: PTHR24261:SF13
organism: Rattus norvegicus

Plasminogen activator inhibitor 2, macrophage
type: ProteinReference
xref: uniprot P12388 24
xref: PTHR11461:SF61
organism: Mus musculus

PTHR10201:SF151
type: RelationshipXref
id: PTHR10201:SF151
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
evidence: Evidence 54
xref: PTHR10201:SF165
xref: uniprot A0A1D5QFN4 53
organism: Macaca mulatta

uniprot P29524 25
type: UnificationXref
id: P29524
db: uniprot

ncbitaxon 9598 8
type: UnificationXref
id: 9598
db: ncbitaxon

GPI linker
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa12 131
cellular location: epithelial cell c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 28

Urokinase plasminogen activator surface receptor
type: ProteinReference
xref: PTHR10624:SF6
xref: uniprot Q03405 96
organism: Homo sapiens

Plasminogen activator
type: ProteinReference
xref: PTHR24264:SF42
xref: uniprot A0A1D5Q7P1 47
organism: Macaca mulatta

uniprot H2QU06 36
type: UnificationXref
id: H2QU06
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__uPAR_GPI_linker_-_pro_uPA-RIGHT__Complex__GPI_linker_uPAR__pro_uPA_-_r2
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 180
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 181
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 182
left: Complex (uPAR/GPI linker)
left: pro-uPA
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GPI linker/uPAR/ pro-uPA)

pro-MMP-3
type: ProteinReference
xref: P01260
standard name: pro-Matrix metalloprotease 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.pro_minus_MMP_minus_3
comment: ENTITY_REFERENCE_NOTES= Long Name: pro-Matrix metalloprotease 3 Synonym: pro-Matrix metalloproteinase 3,pro-stromelysin,pro-stromelysin 1,pro-transin Accession: P01260
member entity reference: MMP3 isoform 1
member entity reference: Stromelysin-1
member entity reference: Uncharacterized protein

uniprot H2Q4N3 74
type: UnificationXref
id: H2Q4N3
db: uniprot

uniprot A0A1D5Q7P1 47
type: UnificationXref
id: A0A1D5Q7P1
db: uniprot

uPA
type: ProteinReference
xref: P01243
standard name: urokinase type plasminogen activator
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.uPA
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Uncharacterized protein
member entity reference: Urokinase-type plasminogen activator
member entity reference: PLAU isoform 1

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 15

PARTICIPANT STOICHIOMETRY r23 194
type: Stoichiometry
physical entity: Complex (GPI linker/uPAR/ uPA/PAI-2)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 192
type: Stoichiometry
physical entity: PAI-2
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YVN6 67
xref: PTHR10201:SF215
organism: Macaca mulatta

GPI linker
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa7 125
cellular location: epithelial cell c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r23 193
type: Stoichiometry
physical entity: Complex (GPI linker/uPAR/ uPA)
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__pro_MMP_13-RIGHT__MMP_13-_?-_r31
controller: Plasmin

Plasminogen
type: ProteinReference
xref: uniprot P20918 39
xref: PTHR24261:SF13
organism: Mus musculus

Plasminogen
type: ProteinReference
xref: PTHR24261:SF13
xref: uniprot F7CC91 35
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r19 162
type: Stoichiometry
physical entity: pro-MMP-3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r19 163
type: Stoichiometry
physical entity: pro-MMP-3
stoichiometric coefficient: 1.0

TAFI
type: Protein
entity reference: TAFI
comment: SPECIES_TYPE=PROTEIN

MMP-9
type: Protein
feature: ACTIVE 41
comment: SPECIES_TYPE=PROTEIN

uniprot Q03405 96
type: UnificationXref
id: Q03405
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot P15120 14
type: UnificationXref
id: P15120
db: uniprot

uniprot F7BTD3 100
type: UnificationXref
id: F7BTD3
db: uniprot

Plasminogen activator, tissue type
type: ProteinReference
xref: PTHR24264:SF42
xref: uniprot H2QW33 49
organism: Pan troglodytes

PTHR10201:SF165
type: RelationshipXref
id: PTHR10201:SF165
db: PANTHER Family
relationship type: By Homology

uniprot H2QQB5 84
type: UnificationXref
id: H2QQB5
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__GPI_linker_uPAR__uPA_-_PAI_1-RIGHT__Complex__uPAR_GPI_linker__uPA_PAI_1_-_r6
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 176
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 177
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 175
left: Complex (GPI linker/uPAR/ uPA)
left: PAI-1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (uPAR/GPI linker/ uPA/PAI-1)

PTHR24264:SF38
type: RelationshipXref
id: PTHR24264:SF38
db: PANTHER Family
relationship type: By Homology

uniprot K7CJD2 7
type: UnificationXref
id: K7CJD2
db: uniprot

Urokinase-type plasminogen activator
type: ProteinReference
xref: uniprot P15120 14
xref: PTHR24264:SF38
organism: Gallus gallus

uniprot H2QW33 49
type: UnificationXref
id: H2QW33
db: uniprot

STATE_TRANSITION_LEFT__Fibrin-RIGHT__Fibrin_C_terminal_truncation-_r16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 168
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 169
left: Fibrin
interaction type: STATE_TRANSITION
right: Fibrin C-terminal truncation

Fgb protein
type: ProteinReference
xref: PTHR19143:SF332
xref: uniprot B0JZ09 78
organism: Xenopus tropicalis

uniprot Q01177 40
type: UnificationXref
id: Q01177
db: uniprot

PARTICIPANT STOICHIOMETRY r17 167
type: Stoichiometry
physical entity: pro-MMP-1
stoichiometric coefficient: 1.0

uniprot H2QV47 30
type: UnificationXref
id: H2QV47
db: uniprot

PARTICIPANT STOICHIOMETRY r17 166
type: Stoichiometry
physical entity: pro-MMP-1
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HQV3 42
organism: Macaca mulatta

HETERODIMER_ASSOCIATION_LEFT__PAI_2-_Complex__GPI_linker_uPAR__uPA_-RIGHT__Complex__GPI_linker_uPAR__uPA_PAI_2_-_r23
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 194
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 193
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 192
left: PAI-2
left: Complex (GPI linker/uPAR/ uPA)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GPI linker/uPAR/ uPA/PAI-2)

PARTICIPANT STOICHIOMETRY r2 182
type: Stoichiometry
physical entity: Complex (GPI linker/uPAR/ pro-uPA)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 180
type: Stoichiometry
physical entity: Complex (uPAR/GPI linker)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 181
type: Stoichiometry
physical entity: pro-uPA
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__tPA-RIGHT__tPA-_r14
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 174
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 173
left: tPA
interaction type: TRANSPORT
right: tPA

PTHR24264:SF42
type: RelationshipXref
id: PTHR24264:SF42
db: PANTHER Family
relationship type: By Homology

GPI linker s14 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GPI linker
stoichiometric coefficient: 1.0

CPB2 isoform 1
type: ProteinReference
xref: uniprot H2Q7J0 43
organism: Pan troglodytes

Complex (GPI linker/uPAR/ uPA/PAI-2)
type: Complex
component stoichiometry: GPI linker s18 sa15 STOICHIOMETRY ID COMPLEX
component stoichiometry: uPA s20 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: PAI 2 s200 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: uPAR s19 sa16 STOICHIOMETRY ID COMPLEX
component: uPA
component: GPI linker
component: uPAR
component: PAI-2
feature: COMPLEX BINDING FEATURE s72 a107 114
feature: COMPLEX BINDING FEATURE s72 a107 118
feature: COMPLEX BINDING FEATURE s72 a107 120
feature: COMPLEX BINDING FEATURE s72 a107 116
cellular location: epithelial cell c2

Plasminogen activator inhibitor 2 type A
type: ProteinReference
xref: PTHR11461:SF61
xref: uniprot P29524 25
organism: Rattus norvegicus

TRUNCATION_LEFT__pro_MMP_3-RIGHT__?-_MMP_3-_r30
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 159
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 160
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 161
left: pro-MMP-3
interaction type: TRUNCATION
right: ?
right: MMP-3

ncbitaxon 9031 15
type: UnificationXref
id: 9031
db: ncbitaxon

ncbitaxon 8364 61
type: UnificationXref
id: 8364
db: ncbitaxon

pro-tPA
type: ProteinReference
xref: P01249
standard name: pro-tissue type plasminogen activator
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.pro_minus_tPA
comment: ENTITY_REFERENCE_NOTES= Long Name: pro-tissue type plasminogen activator Synonym: pro-Tissue type plasminogen activator,pro-alteplase,pro-plasminogen activator, tissue,pro-tissue plasminogen activator Accession: P01249
member entity reference: Tissue-type plasminogen activator
member entity reference: Plasminogen activator
member entity reference: Plasminogen activator, tissue type

ncbitaxon 10116 17
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot O70138 63
type: UnificationXref
id: O70138
db: uniprot

PARTICIPANT STOICHIOMETRY r14 173
type: Stoichiometry
physical entity: tPA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 174
type: Stoichiometry
physical entity: tPA
stoichiometric coefficient: 1.0

ncbitaxon 9913 19
type: UnificationXref
id: 9913
db: ncbitaxon

PTHR11461:SF20
type: RelationshipXref
id: PTHR11461:SF20
db: PANTHER Family
relationship type: By Homology

eco ECO:0000316 13
type: UnificationXref
id: ECO:0000316
db: eco

uniprot P06399 89
type: UnificationXref
id: P06399
db: uniprot

uniprot B0JZ09 78
type: UnificationXref
id: B0JZ09
db: uniprot

uniprot P33435 65
type: UnificationXref
id: P33435
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Fibrin-_Plasminogen-RIGHT__?-_Plasmin-_r32
controller: tPA

Apolipoprotein(a)
type: ProteinReference
xref: uniprot P08519 38
xref: PTHR24261:SF2
organism: Homo sapiens

pro-MMP-1
type: Protein
entity reference: pro-MMP-1
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r15 172
type: Stoichiometry
physical entity: Complex (Plasmin/alpha2 antiplasmin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r15 171
type: Stoichiometry
physical entity: alpha2 antiplasmin
stoichiometric coefficient: 1.0

uniprot Q96IY4 44
type: UnificationXref
id: Q96IY4
db: uniprot

Stromelysin-1
type: ProteinReference
xref: uniprot P28862 72
xref: PTHR10201:SF215
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r15 170
type: Stoichiometry
physical entity: Plasmin
stoichiometric coefficient: 1.0

MMP-13
type: ProteinReference
xref: P01250
standard name: Matrix metalloprotease 13
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.MMP_minus_13
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Matrix metalloprotease 13 Synonym: Collagenase 3,Matrix metalloproteinase 13 Accession: P01250
member entity reference: Matrix metallopeptidase 13
member entity reference: Collagenase 3
member entity reference: Neutrophil collagenase
member entity reference: Matrix metallopeptidase 13 (collagenase 3)-like
member entity reference: Uncharacterized protein

uniprot Q9JHH6 46
type: UnificationXref
id: Q9JHH6
db: uniprot

Carboxypeptidase B2
type: ProteinReference
xref: uniprot Q9JHH6 46
xref: PTHR11705:SF17
organism: Mus musculus

TRANSPORT
type: RelationshipTypeVocabulary

TAFI
type: ProteinReference
xref: P01247
standard name: thrombin activatable fibrinolysis inhibitor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: thrombin activatable fibrinolysis inhibitor Synonym: Thrombin activatable fibrinolysis inhibitor,carboxypeptidase R,carboxypeptidase U,procarboxypeptidase B2 Accession: P01247
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.TAFI
member entity reference: Uncharacterized protein
member entity reference: Carboxypeptidase B2
member entity reference: CPB2 isoform 1

P01246
type: UnificationXref
id: P01246
db: PANTHER Pathway Component

P01245
type: UnificationXref
id: P01245
db: PANTHER Pathway Component

Alpha-2-antiplasmin
type: ProteinReference
xref: PTHR11461:SF20
xref: uniprot P08697 101
organism: Homo sapiens

P01244
type: UnificationXref
id: P01244
db: PANTHER Pathway Component

P01243
type: UnificationXref
id: P01243
db: PANTHER Pathway Component

P01247
type: UnificationXref
id: P01247
db: PANTHER Pathway Component

P01249
type: UnificationXref
id: P01249
db: PANTHER Pathway Component

uniprot F1PVS9 57
type: UnificationXref
id: F1PVS9
db: uniprot

PTHR19143:SF338
type: RelationshipXref
id: PTHR19143:SF338
db: PANTHER Family
relationship type: By Homology

uniprot A0A452DIJ9 26
type: UnificationXref
id: A0A452DIJ9
db: uniprot

alpha2 antiplasmin
type: Protein
entity reference: alpha2 antiplasmin
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa11 139
comment: SPECIES_TYPE=PROTEIN

Matrix metallopeptidase 13
type: ProteinReference
evidence: Evidence 59
xref: PTHR10201:SF165
xref: uniprot F1PVS9 57
organism: Canis lupus familiaris

PTHR19143:SF332
type: RelationshipXref
id: PTHR19143:SF332
db: PANTHER Family
relationship type: By Homology

uniprot P03957 69
type: UnificationXref
id: P03957
db: uniprot

Collagenase 3
type: ProteinReference
xref: PTHR10201:SF165
xref: uniprot P45452 66
organism: Homo sapiens

Thrombus (fibrin clot)
type: PhysicalEntity
comment: SPECIES_TYPE=UNKNOWN

pro-MMP-1
type: Protein
entity reference: pro-MMP-1
cellular location: fibroblast c4
comment: SPECIES_TYPE=PROTEIN

pro-MMP-13
type: Protein
entity reference: pro-MMP-13
comment: SPECIES_TYPE=PROTEIN

P01251
type: UnificationXref
id: P01251
db: PANTHER Pathway Component

P01250
type: UnificationXref
id: P01250
db: PANTHER Pathway Component

P01253
type: UnificationXref
id: P01253
db: PANTHER Pathway Component

uniprot F6WYF2 73
type: UnificationXref
id: F6WYF2
db: uniprot

P01252
type: UnificationXref
id: P01252
db: PANTHER Pathway Component

P01255
type: UnificationXref
id: P01255
db: PANTHER Pathway Component

P01254
type: UnificationXref
id: P01254
db: PANTHER Pathway Component

P01257
type: UnificationXref
id: P01257
db: PANTHER Pathway Component

P01256
type: UnificationXref
id: P01256
db: PANTHER Pathway Component

uPA s12 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: uPA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r31 156
type: Stoichiometry
physical entity: pro-MMP-13
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r31 158
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r31 157
type: Stoichiometry
physical entity: MMP-13
stoichiometric coefficient: 1.0

P01258
type: UnificationXref
id: P01258
db: PANTHER Pathway Component

P01259
type: UnificationXref
id: P01259
db: PANTHER Pathway Component

uniprot P02671 85
type: UnificationXref
id: P02671
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 5

PARTICIPANT STOICHIOMETRY r30 159
type: Stoichiometry
physical entity: pro-MMP-3
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Fibrin-_Plasminogen-RIGHT__?-_Plasmin-_r32
controller: Complex (GPI linker/uPAR/ uPA)

P01260
type: UnificationXref
id: P01260
db: PANTHER Pathway Component

P01264
type: UnificationXref
id: P01264
db: PANTHER Pathway Component

P01263
type: UnificationXref
id: P01263
db: PANTHER Pathway Component

P01262
type: UnificationXref
id: P01262
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r30 161
type: Stoichiometry
physical entity: MMP-3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r30 160
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

TRUNCATION_LEFT__Complex__GPI_linker_uPAR__pro_uPA_-RIGHT__?-_Complex__GPI_linker_uPAR__uPA_-_r33
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 149
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 151
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 150
left: Complex (GPI linker/uPAR/ pro-uPA)
interaction type: TRUNCATION
right: ?
right: Complex (GPI linker/uPAR/ uPA)

pro-MMP-13
type: Protein
entity reference: pro-MMP-13
cellular location: fibroblast c4
comment: SPECIES_TYPE=PROTEIN

pro-uPA
type: Protein
entity reference: pro-uPA
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa14 135
cellular location: epithelial cell c2
comment: SPECIES_TYPE=PROTEIN

Complex (uPAR/GPI linker/ uPA/PAI-1)
type: Complex
component stoichiometry: GPI linker s14 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: uPAR s13 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: uPA s16 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: PAI 1 s17 sa9 STOICHIOMETRY ID COMPLEX
component: GPI linker
component: PAI-1
component: uPA
component: uPAR
feature: COMPLEX BINDING FEATURE s34 a51 124
feature: COMPLEX BINDING FEATURE s34 a51 122
feature: COMPLEX BINDING FEATURE s34 a51 128
feature: COMPLEX BINDING FEATURE s34 a51 126
cellular location: epithelial cell c2

uniprot H2QEN1 21
type: UnificationXref
id: H2QEN1
db: uniprot

IEP
type: EvidenceCodeVocabulary
xref: eco ECO:0000270 70

Plasminogen activator inhibitor 1
type: ProteinReference
xref: PTHR11461:SF49
xref: uniprot P05121 31
organism: Homo sapiens

Evidence 59
type: Evidence
evidence code: TAS
comment: free text Fang,Y.,Kitchell,B.E.,Paria,B.andBalkin,R.

FGG isoform 5
type: ProteinReference
xref: uniprot A0A2I3T2M5 77
xref: PTHR19143:SF338
organism: Pan troglodytes

Plasminogen activator inhibitor 2
type: ProteinReference
xref: uniprot P05120 22
xref: PTHR11461:SF61
organism: Homo sapiens

Evidence 54
type: Evidence
evidence code: ISS
comment: free text Fang,Y.,Kitchell,B.E.,Paria,B.andBalkin,R.

GPI linker
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa2 143
cellular location: epithelial cell c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Urokinase-type plasminogen activator
type: ProteinReference
xref: PTHR24264:SF38
xref: uniprot Q05589 18
organism: Bos taurus

Urokinase plasminogen activator surface receptor
type: ProteinReference
xref: PTHR10624:SF6
xref: uniprot Q05588 98
organism: Bos taurus

uPAR
type: ProteinReference
xref: P01256
standard name: urokinase type plasminogen activator receptor
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.RECEPTOR.uPAR
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Urokinase plasminogen activator surface receptor

PAI 1 s17 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PAI-1
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BV78 79
xref: PTHR19143:SF338
organism: Gallus gallus

uPAR
type: Protein
entity reference: uPAR
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa4 107
cellular location: epithelial cell c2
comment: SPECIES_TYPE=PROTEIN

alpha2 antiplasmin
type: Protein
entity reference: alpha2 antiplasmin
comment: SPECIES_TYPE=PROTEIN

TRUNCATION_LEFT__pro_MMP_9-RIGHT__?-_MMP_9-_r28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 183
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 185
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 184
left: pro-MMP-9
interaction type: TRUNCATION
right: ?
right: MMP-9

TRANSPORT_LEFT__pro_MMP_9-RIGHT__pro_MMP_9-_r18
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 164
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 165
left: pro-MMP-9
interaction type: TRANSPORT
right: pro-MMP-9

uPAR s7 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: uPAR
stoichiometric coefficient: 1.0

uniprot P19637 52
type: UnificationXref
id: P19637
db: uniprot

Tissue-type plasminogen activator
type: ProteinReference
xref: PTHR24264:SF42
xref: uniprot A0A452DIF6 48
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r18 165
type: Stoichiometry
physical entity: pro-MMP-9
stoichiometric coefficient: 1.0

Plasminogen
type: ProteinReference
xref: P01255
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Plasminogen Synonym: Synonym not specified Accession: P01255
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.Plasminogen
member entity reference: Plasminogen
member entity reference: Apolipoprotein(a)

uniprot H2Q7J0 43
type: UnificationXref
id: H2Q7J0
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 10

PARTICIPANT STOICHIOMETRY r18 164
type: Stoichiometry
physical entity: pro-MMP-9
stoichiometric coefficient: 1.0

uniprot P45452 66
type: UnificationXref
id: P45452
db: uniprot

Collagenase 3
type: ProteinReference
evidence: Evidence 54
xref: PTHR10201:SF165
xref: uniprot F1MW26 56
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r26 190
type: Stoichiometry
physical entity: tPA
stoichiometric coefficient: 1.0

Alpha-2-antiplasmin
type: ProteinReference
xref: PTHR11461:SF20
xref: uniprot P28800 102
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r26 191
type: Stoichiometry
physical entity: Complex (PAI-1/tPA)
stoichiometric coefficient: 1.0

PAI-2
type: Protein
entity reference: PAI-2
feature: COMPLEX PARTICIPANT BINDING FEATURE s200 sa18 121
cellular location: epithelial cell c2
comment: SPECIES_TYPE=PROTEIN

tPA
type: ProteinReference
xref: P01257
standard name: tissue type plasminogen activator
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: tissue type plasminogen activator Synonym: PLAT,Tissue plasminogen activator,alteplase,plasminogen activator, tissue type Accession: P01257
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.tPA
member entity reference: Tissue-type plasminogen activator
member entity reference: Plasminogen activator
member entity reference: Plasminogen activator, tissue type

PARTICIPANT STOICHIOMETRY r26 189
type: Stoichiometry
physical entity: PAI-1
stoichiometric coefficient: 1.0

Fibrinogen gamma chain
type: ProteinReference
xref: PTHR19143:SF338
xref: uniprot Q8VCM7 94
organism: Mus musculus

uniprot P08254 71
type: UnificationXref
id: P08254
db: uniprot

Serpin family B member 2
type: ProteinReference
xref: PTHR11461:SF61
xref: uniprot H2QEN1 21
organism: Pan troglodytes

PTHR10201:SF215
type: RelationshipXref
id: PTHR10201:SF215
db: PANTHER Family
relationship type: By Homology

Plasminogen
type: ProteinReference
xref: uniprot P00747 37
xref: PTHR24261:SF13
organism: Homo sapiens

uniprot P00749 9
type: UnificationXref
id: P00749
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__PAI_1-_tPA-RIGHT__Complex__PAI_1_tPA_-_r26
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 190
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 189
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 191
left: tPA
left: PAI-1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (PAI-1/tPA)

epithelial cell c2
type: CellularLocationVocabulary
comment: epithelial cell

Urokinase-type plasminogen activator
type: ProteinReference
xref: PTHR24264:SF38
xref: uniprot P00749 9
organism: Homo sapiens

Tissue-type plasminogen activator
type: ProteinReference
xref: PTHR24264:SF42
xref: uniprot P00750 50
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR11461:SF20
xref: uniprot F7BTD3 100
organism: Macaca mulatta

Complex (PAI-1/tPA)
type: Complex
component stoichiometry: PAI 1 s23 sa19 STOICHIOMETRY ID COMPLEX
component stoichiometry: tPA s26 sa20 STOICHIOMETRY ID COMPLEX
component: PAI-1
component: tPA
feature: COMPLEX BINDING FEATURE s73 a111 112
feature: COMPLEX BINDING FEATURE s73 a111 110

Neutrophil collagenase
type: ProteinReference
xref: uniprot O88766 64
xref: PTHR10201:SF137
organism: Rattus norvegicus

TRUNCATION_LEFT__Fibrin-_Plasminogen-RIGHT__?-_Plasmin-_r32
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 153
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 155
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 154
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 152
left: Fibrin
left: Plasminogen
interaction type: TRUNCATION
right: ?
right: Plasmin

Plasminogen
type: Protein
entity reference: Plasminogen
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r22 145
type: Stoichiometry
physical entity: pro-MMP-13
stoichiometric coefficient: 1.0

GPI linker s9 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GPI linker
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 144
type: Stoichiometry
physical entity: pro-MMP-13
stoichiometric coefficient: 1.0

uniprot P00750 50
type: UnificationXref
id: P00750
db: uniprot

uniprot A0A1D5QFN4 53
type: UnificationXref
id: A0A1D5QFN4
db: uniprot

ncbitaxon 10090 12
type: UnificationXref
id: 10090
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UZ20 81
xref: PTHR19143:SF338
organism: Macaca mulatta

tPA s26 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: tPA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r28 183
type: Stoichiometry
physical entity: pro-MMP-9
stoichiometric coefficient: 1.0

MMP-3
type: ProteinReference
xref: P01251
standard name: Matrix metalloprotease 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Matrix metalloprotease 3 Synonym: Fibroblast stromelysin,Matrix metalloprotease 3,Matrix metalloproteinase 3,Stromelysin,Transin Accession: P01251
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.MMP_minus_3
member entity reference: MMP3 isoform 1
member entity reference: Stromelysin-1
member entity reference: Uncharacterized protein

uniprot F1NUL9 80
type: UnificationXref
id: F1NUL9
db: uniprot

IDA
type: EvidenceCodeVocabulary

PARTICIPANT STOICHIOMETRY r27 187
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r27 188
type: Stoichiometry
physical entity: MMP-1
stoichiometric coefficient: 1.0

Matrix metallopeptidase 13
type: ProteinReference
xref: PTHR10201:SF165
xref: uniprot A0A2I3SHB6 55
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r27 186
type: Stoichiometry
physical entity: pro-MMP-1
stoichiometric coefficient: 1.0

MMP-3
type: Protein
entity reference: MMP-3
feature: ACTIVE 41
comment: SPECIES_TYPE=PROTEIN

pro-MMP-9
type: ProteinReference
xref: P01259
standard name: pro-matrix metalloprotease 9
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.pro_minus_MMP_minus_9
comment: ENTITY_REFERENCE_NOTES= Long Name: pro-matrix metalloprotease 9 Synonym: pro-Gelatinase B,pro-Matrix metalloproteinase 9 Accession: P01259
member entity reference: Matrix metalloproteinase-9

uniprot H2QQB4 83
type: UnificationXref
id: H2QQB4
db: uniprot

PAI 1 s23 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PAI-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r33 150
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

Alpha-2-antiplasmin
type: ProteinReference
xref: PTHR11461:SF20
xref: uniprot Q61247 103
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r33 151
type: Stoichiometry
physical entity: Complex (GPI linker/uPAR/ uPA)
stoichiometric coefficient: 1.0

uniprot A0A452DIF6 48
type: UnificationXref
id: A0A452DIF6
db: uniprot

uniprot P20961 32
type: UnificationXref
id: P20961
db: uniprot

eco ECO:0000304 58
type: UnificationXref
id: ECO:0000304
db: eco

Matrix metalloproteinase-9
type: ProteinReference
xref: PTHR10201:SF30
xref: uniprot P14780 99
organism: Homo sapiens

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot P08697 101
type: UnificationXref
id: P08697
db: uniprot

uniprot F6TWU5 20
type: UnificationXref
id: F6TWU5
db: uniprot

Interstitial collagenase
type: ProteinReference
xref: PTHR10201:SF151
xref: uniprot P28053 76
organism: Bos taurus

Plasmin
type: ProteinReference
xref: P01246
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Plasmin Synonym: Synonym not specified Accession: P01246
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.Plasmin
member entity reference: Plasminogen
member entity reference: Apolipoprotein(a)

Fibrin C-terminal truncation
type: ProteinReference
xref: P01258
standard name: Fibrin degradation products
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.TRUNCATED.Fibrin_space_C-terminal_space_truncation
comment: ENTITY_REFERENCE_NOTES= Long Name: Fibrin degradation products Synonym: Fibrin C-terminal truncation Accession: P01258
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
member entity reference: Fibrinogen alpha chain
member entity reference: FGA isoform 1

uniprot P12388 24
type: UnificationXref
id: P12388
db: uniprot

GPI linker s18 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GPI linker
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r28 185
type: Stoichiometry
physical entity: MMP-9
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r33 149
type: Stoichiometry
physical entity: Complex (GPI linker/uPAR/ pro-uPA)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r28 184
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 58

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__pro_MMP_9-RIGHT__?-_MMP_9-_r28
controller: Plasmin

pro-MMP-9
type: Protein
entity reference: pro-MMP-9
cellular location: fibroblast c4
comment: SPECIES_TYPE=PROTEIN

uniprot H2Q4N2 68
type: UnificationXref
id: H2Q4N2
db: uniprot

PTHR47221:SF1
type: RelationshipXref
id: PTHR47221:SF1
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__pro_MMP_1-RIGHT__?-_MMP_1-_r27
controller: Plasmin

uPAR s19 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: uPAR
stoichiometric coefficient: 1.0

tPA
type: Protein
entity reference: tPA
feature: ACTIVE 41
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__pro_MMP_1-RIGHT__pro_MMP_1-_r17
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 166
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 167
left: pro-MMP-1
interaction type: TRANSPORT
right: pro-MMP-1

PAI-1
type: Protein
entity reference: PAI-1
comment: SPECIES_TYPE=PROTEIN

uPAR s13 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: uPAR
stoichiometric coefficient: 1.0

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 17

Complex (GPI linker/uPAR/ uPA)
type: Complex
component stoichiometry: GPI linker s9 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: uPAR s10 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: uPA s12 sa5 STOICHIOMETRY ID COMPLEX
component: uPAR
component: GPI linker
component: uPA
feature: COMPLEX BINDING FEATURE s21 a36 106
feature: COMPLEX BINDING FEATURE s21 a36 108
feature: ACTIVE 41
feature: COMPLEX BINDING FEATURE s21 a36 104
cellular location: epithelial cell c2

uniprot P28862 72
type: UnificationXref
id: P28862
db: uniprot

uPA
type: Protein
entity reference: uPA
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa17 119
cellular location: epithelial cell c2
comment: SPECIES_TYPE=PROTEIN

uniprot F6Y5D7 29
type: UnificationXref
id: F6Y5D7
db: uniprot

uniprot P35456 95
type: UnificationXref
id: P35456
db: uniprot

GPI linker
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa3 105
cellular location: epithelial cell c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

INHIBITION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY r12 178
type: Stoichiometry
physical entity: Thrombus (fibrin clot)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r12 179
type: Stoichiometry
physical entity: Fibrin
stoichiometric coefficient: 1.0

uniprot A0A2I3SHB6 55
type: UnificationXref
id: A0A2I3SHB6
db: uniprot

Serpin family E member 1
type: ProteinReference
xref: uniprot F1PUI4 27
xref: PTHR11461:SF49
organism: Canis lupus familiaris

uPA
type: Protein
entity reference: uPA
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa8 127
cellular location: epithelial cell c2
comment: SPECIES_TYPE=PROTEIN

TRUNCATION_LEFT__pro_MMP_1-RIGHT__?-_MMP_1-_r27
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 186
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 187
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 188
left: pro-MMP-1
interaction type: TRUNCATION
right: ?
right: MMP-1

Uncharacterized protein
type: ProteinReference
xref: PTHR10201:SF151
xref: uniprot F6WYF2 73
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR11461:SF61
xref: uniprot F6TWU5 20
organism: Macaca mulatta

ACTIVE 41
type: EntityFeature
comment: Active state

uniprot P00747 37
type: UnificationXref
id: P00747
db: uniprot

uPAR
type: Protein
entity reference: uPAR
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa16 117
cellular location: epithelial cell c2
comment: SPECIES_TYPE=PROTEIN

tPA
type: Protein
entity reference: tPA
feature: ACTIVE 41
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

?
type: Protein
comment: SPECIES_TYPE=PROTEIN

PTHR24261:SF2
type: RelationshipXref
id: PTHR24261:SF2
db: PANTHER Family
relationship type: By Homology

uniprot F6SRT1 60
type: UnificationXref
id: F6SRT1
db: uniprot

uniprot P08519 38
type: UnificationXref
id: P08519
db: uniprot

Plasminogen activator inhibitor 1
type: ProteinReference
xref: PTHR11461:SF49
xref: uniprot P22777 33
organism: Mus musculus

PAI-1
type: ProteinReference
xref: P01245
standard name: plasminogen activator inhibitor type-1
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.PAI_minus_1
comment: ENTITY_REFERENCE_NOTES= Long Name: PAI-1 Synonym: Endothelial plasminogen activator inhibitor,Plasminogen activator inhibitor 1,Serpin E1 Accession: P01245
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Plasminogen activator inhibitor 1
member entity reference: SERPINE1 isoform 1
member entity reference: Uncharacterized protein
member entity reference: Serpin family E member 1

Complex (Plasmin/alpha2 antiplasmin)
type: Complex
component stoichiometry: Plasmin s1 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: alpha2 antiplasmin s2 sa11 STOICHIOMETRY ID COMPLEX
component: alpha2 antiplasmin
component: Plasmin
feature: COMPLEX BINDING FEATURE s51 a76 138
feature: COMPLEX BINDING FEATURE s51 a76 136

Fibrinogen alpha chain
type: ProteinReference
xref: uniprot P06399 89
xref: PTHR47221:SF1
organism: Rattus norvegicus

Urokinase-type plasminogen activator
type: ProteinReference
xref: uniprot P06869 11
xref: PTHR24264:SF38
organism: Mus musculus

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

uniprot P02675 86
type: UnificationXref
id: P02675
db: uniprot

TRUNCATION
type: InteractionVocabulary

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Thrombus__fibrin_clot_-RIGHT__Fibrin-_r12
controller: Plasmin

uniprot P03956 75
type: UnificationXref
id: P03956
db: uniprot

Fibrinogen beta chain
type: ProteinReference
xref: PTHR19143:SF332
xref: uniprot P14480 92
organism: Rattus norvegicus

Urokinase plasminogen activator surface receptor
type: ProteinReference
xref: PTHR10624:SF6
xref: uniprot P35456 95
organism: Mus musculus

Fibrinogen alpha chain
type: ProteinReference
xref: PTHR47221:SF1
xref: uniprot P02671 85
organism: Homo sapiens

uniprot P02679 88
type: UnificationXref
id: P02679
db: uniprot

pro-MMP-3
type: Protein
entity reference: pro-MMP-3
comment: SPECIES_TYPE=PROTEIN

uniprot Q9EQV9 45
type: UnificationXref
id: Q9EQV9
db: uniprot

ncbitaxon 9615 28
type: UnificationXref
id: 9615
db: ncbitaxon

Fibrinogen gamma chain
type: ProteinReference
xref: uniprot P02679 88
xref: PTHR19143:SF338
organism: Homo sapiens

Fibrinogen beta chain
type: ProteinReference
xref: uniprot P02676 87
organism: Bos taurus

PTHR19143:SF232
type: RelationshipXref
id: PTHR19143:SF232
db: PANTHER Family
relationship type: By Homology

Matrix metallopeptidase 13 (collagenase 3)-like
type: ProteinReference
xref: PTHR10201:SF165
xref: uniprot F6SRT1 60
organism: Xenopus tropicalis

Fibrinogen beta chain
type: ProteinReference
xref: PTHR19143:SF332
xref: uniprot P02675 86
organism: Homo sapiens

PANTHER Pathway P00050 1
type: UnificationXref
id: P00050
db: PANTHER Pathway

uniprot E1B726 34
type: UnificationXref
id: E1B726
db: uniprot

uniprot O88766 64
type: UnificationXref
id: O88766
db: uniprot

Carboxypeptidase B2
type: ProteinReference
xref: PTHR11705:SF17
xref: uniprot Q96IY4 44
organism: Homo sapiens

PLAU isoform 1
type: ProteinReference
xref: PTHR24264:SF38
xref: uniprot K7CJD2 7
organism: Pan troglodytes

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

PTHR24261:SF13
type: RelationshipXref
id: PTHR24261:SF13
db: PANTHER Family
relationship type: By Homology

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 13

PAI-2
type: ProteinReference
xref: P01244
standard name: plasminogen activator-inhibitors type 2
comment: ENTITY_REFERENCE_ID_DESC=Plasminogen activating cascade.PROTEIN.GENERIC.PAI_minus_2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: PAI-2 Synonym: Monocyte Arginine serpin,Monocyte derived Plasminogen activator inhibitor,PLANH2,Plasminogen activator inhibitor 2,Serpin B2,Urokinase inhibitor Accession: P01244
member entity reference: Serpin family B member 2
member entity reference: Plasminogen activator inhibitor 2
member entity reference: Uncharacterized protein
member entity reference: Plasminogen activator inhibitor 2 type A
member entity reference: Plasminogen activator inhibitor 2, macrophage

pro-uPA
type: Protein
entity reference: pro-uPA
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot G3V742 62
type: UnificationXref
id: G3V742
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11461:SF49
xref: uniprot F6Y5D7 29
organism: Macaca mulatta

?
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P14480 92
type: UnificationXref
id: P14480
db: uniprot

uniprot P05120 22
type: UnificationXref
id: P05120
db: uniprot

Collagenase 3
type: ProteinReference
xref: PTHR10201:SF165
xref: uniprot P33435 65
organism: Mus musculus

uniprot P06869 11
type: UnificationXref
id: P06869
db: uniprot

FGB isoform 1
type: ProteinReference
xref: uniprot H2QQB4 83
xref: PTHR19143:SF332
organism: Pan troglodytes

FGA isoform 1
type: ProteinReference
xref: PTHR47221:SF1
xref: uniprot H2QQB5 84
organism: Pan troglodytes

uniprot F7CC91 35
type: UnificationXref
id: F7CC91
db: uniprot

GPI linker s5 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GPI linker
stoichiometric coefficient: 1.0