CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__pyrroline_5_carboxylate-_NADPH-RIGHT__NADP-_L_Proline-_r4
controller: Pyrroline-5-carboxylate reductase

NADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9RDJ9 40
type: UnificationXref
id: Q9RDJ9
db: uniprot

Gamma-glutamyl phosphate reductase
type: ProteinReference
xref: uniprot Q9RTD9 21
organism: Deinococcus radiodurans

ncbitaxon 284812 24
type: UnificationXref
id: 284812
db: ncbitaxon

ncbitaxon 243230 22
type: UnificationXref
id: 243230
db: ncbitaxon

Glutamate 5-kinase
type: ProteinReference
xref: uniprot Q9RTD8 41
organism: Deinococcus radiodurans

ncbitaxon 208964 18
type: UnificationXref
id: 208964
db: ncbitaxon

PANTHER Pathway P02768 1
type: UnificationXref
id: P02768
db: PANTHER Pathway

Glutamate 5-kinase
type: ProteinReference
xref: uniprot O67209 29
organism: Aquifex aeolicus

ncbitaxon 243274 26
type: UnificationXref
id: 243274
db: ncbitaxon

uniprot Q55167 14
type: UnificationXref
id: Q55167
db: uniprot

uniprot Q9HHA1 15
type: UnificationXref
id: Q9HHA1
db: uniprot

ncbitaxon 83332 13
type: UnificationXref
id: 83332
db: ncbitaxon

ncbitaxon 224324 3
type: UnificationXref
id: 224324
db: ncbitaxon

Glutamate 5-kinase
type: ProteinReference
xref: uniprot Q9RDJ9 40
organism: Streptomyces coelicolor

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 5

Gamma-glutamyl phosphate reductase
type: ProteinReference
xref: uniprot Q9HHA1 15
organism: Methanosarcina acetivorans

uniprot O67209 29
type: UnificationXref
id: O67209
db: uniprot

Glutamate 5-kinase
type: ProteinReference
xref: uniprot Q9HHA0 38
organism: Methanosarcina acetivorans

glutamate semialdehyde
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r1 53
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 52
type: Stoichiometry
physical entity: glutamate-5-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 51
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot P39821 4
type: UnificationXref
id: P39821
db: uniprot

PARTICIPANT STOICHIOMETRY r1 50
type: Stoichiometry
physical entity: L-Glutamate
stoichiometric coefficient: 1.0

Glutamate 5-kinase
type: ProteinReference
xref: uniprot P0A7B5 30
organism: Escherichia coli

ncbitaxon 224308 5
type: UnificationXref
id: 224308
db: ncbitaxon

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 26

pyrroline-5-carboxylate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Gamma-glutamyl phosphate reductase
type: ProteinReference
xref: uniprot Q9RDK1 19
organism: Streptomyces coelicolor

Uncharacterized protein YHR033W
type: ProteinReference
xref: uniprot P38690 33
organism: Saccharomyces cerevisiae

Glutamate 5-kinase
type: ProteinReference
xref: uniprot P32264 32
organism: Saccharomyces cerevisiae

Probable glutamate 5-kinase
type: ProteinReference
xref: uniprot O13810 28
organism: Schizosaccharomyces pombe

uniprot P94871 36
type: UnificationXref
id: P94871
db: uniprot

ncbitaxon 188937 16
type: UnificationXref
id: 188937
db: ncbitaxon

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 7

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 9

Probable gamma-glutamyl phosphate reductase
type: ProteinReference
xref: uniprot Q9UT44 23
organism: Schizosaccharomyces pombe

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 16

uniprot Q9HX20 17
type: UnificationXref
id: Q9HX20
db: uniprot

ncbitaxon 559292 7
type: UnificationXref
id: 559292
db: ncbitaxon

ncbitaxon 100226 20
type: UnificationXref
id: 100226
db: ncbitaxon

STATE_TRANSITION_LEFT__glutamate_5_phosphate-_NADPH-RIGHT__glutamate_semialdehyde-_NADP-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 49
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 48
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 47
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 46
left: NADPH
left: glutamate-5-phosphate
interaction type: STATE_TRANSITION
right: NADP
right: glutamate semialdehyde

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 3

ncbitaxon 1111708 9
type: UnificationXref
id: 1111708
db: ncbitaxon

uniprot Q9UT44 23
type: UnificationXref
id: Q9UT44
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__glutamate_5_phosphate-_NADPH-RIGHT__glutamate_semialdehyde-_NADP-_r2
controller: Glutamate semialdehyde dehydrogenase

uniprot O07509 27
type: UnificationXref
id: O07509
db: uniprot

Glutamate 5-kinase
type: ProteinReference
xref: uniprot P73071 35
organism: Synechocystis

Gamma-glutamyl phosphate reductase 1
type: ProteinReference
xref: uniprot P54902 8
organism: Synechocystis

uniprot O67166 2
type: UnificationXref
id: O67166
db: uniprot

Glutamate 5-kinase
type: ProteinReference
xref: uniprot P94871 36
organism: Leptospira interrogans

Gamma-glutamyl phosphate reductase
type: ProteinReference
xref: uniprot P94872 10
organism: Leptospira interrogans

uniprot P54902 8
type: UnificationXref
id: P54902
db: uniprot

Glutamyl kinase
type: Protein
entity reference: Glutamyl kinase
comment: SPECIES_TYPE=PROTEIN

Glutamate semialdehyde dehydrogenase
type: Protein
entity reference: Glutamate semialdehyde dehydrogenase
comment: SPECIES_TYPE=PROTEIN

uniprot P9WHU9 37
type: UnificationXref
id: P9WHU9
db: uniprot

STATE_TRANSITION_LEFT__glutamate_semialdehyde-RIGHT__H2O-_pyrroline_5_carboxylate-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 43
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 44
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 45
left: glutamate semialdehyde
interaction type: STATE_TRANSITION
right: pyrroline-5-carboxylate
right: H2O

uniprot Q9WYC9 25
type: UnificationXref
id: Q9WYC9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__L_Glutamate-_ATP-RIGHT__glutamate_5_phosphate-_ADP-_r1
controller: Glutamyl kinase

PARTICIPANT STOICHIOMETRY r2 49
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 54
type: Stoichiometry
physical entity: pyrroline-5-carboxylate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 48
type: Stoichiometry
physical entity: glutamate semialdehyde
stoichiometric coefficient: 1.0

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 24

PARTICIPANT STOICHIOMETRY r4 55
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 47
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Gamma-glutamyl phosphate reductase
type: ProteinReference
xref: uniprot O67166 2
organism: Aquifex aeolicus

PARTICIPANT STOICHIOMETRY r4 56
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 57
type: Stoichiometry
physical entity: L-Proline
stoichiometric coefficient: 1.0

Gamma-glutamyl phosphate reductase 2
type: ProteinReference
xref: uniprot Q55167 14
organism: Synechocystis

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 20

Gamma-glutamyl phosphate reductase
type: ProteinReference
xref: uniprot Q9WYC9 25
organism: Thermotoga maritima

STATE_TRANSITION_LEFT__L_Glutamate-_ATP-RIGHT__glutamate_5_phosphate-_ADP-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 51
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 50
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 53
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 52
left: ATP
left: L-Glutamate
interaction type: STATE_TRANSITION
right: glutamate-5-phosphate
right: ADP

PARTICIPANT STOICHIOMETRY r2 46
type: Stoichiometry
physical entity: glutamate-5-phosphate
stoichiometric coefficient: 1.0

uniprot Q9RDK1 19
type: UnificationXref
id: Q9RDK1
db: uniprot

Gamma-glutamyl phosphate reductase
type: ProteinReference
xref: uniprot P54885 6
organism: Saccharomyces cerevisiae

uniprot P32264 32
type: UnificationXref
id: P32264
db: uniprot

ncbitaxon 83333 31
type: UnificationXref
id: 83333
db: ncbitaxon

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

glutamate-5-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9HHA0 38
type: UnificationXref
id: Q9HHA0
db: uniprot

ncbitaxon 189518 11
type: UnificationXref
id: 189518
db: ncbitaxon

Glutamate semialdehyde dehydrogenase
type: ProteinReference
xref: P03112
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Proline biosynthesis.PROTEIN.GENERIC.Glutamate semialdehyde dehydrogenase
comment: ENTITY_REFERENCE_NOTES= Long Name: Glutamate semialdehyde dehydrogenase Synonym: Synonym not specified Accession: P03112
member entity reference: Gamma-glutamyl phosphate reductase
member entity reference: Probable gamma-glutamyl phosphate reductase
member entity reference: Gamma-glutamyl phosphate reductase 1
member entity reference: Gamma-glutamyl phosphate reductase 2

Glutamate 5-kinase 2
type: ProteinReference
xref: uniprot O07509 27
organism: Bacillus subtilis

uniprot P9WHV1 12
type: UnificationXref
id: P9WHV1
db: uniprot

uniprot P38690 33
type: UnificationXref
id: P38690
db: uniprot

uniprot P0A7B5 30
type: UnificationXref
id: P0A7B5
db: uniprot

uniprot Q9RTD8 41
type: UnificationXref
id: Q9RTD8
db: uniprot

P03112
type: UnificationXref
id: P03112
db: PANTHER Pathway Component

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 11

Glutamyl kinase
type: ProteinReference
xref: P03114
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Glutamyl kinase Synonym: Synonym not specified Accession: P03114
comment: ENTITY_REFERENCE_ID_DESC=Proline biosynthesis.PROTEIN.GENERIC.Glutamyl kinase
member entity reference: Uncharacterized protein YHR033W
member entity reference: Glutamate 5-kinase
member entity reference: Probable glutamate 5-kinase
member entity reference: Glutamate 5-kinase 1
member entity reference: Glutamate 5-kinase 2

P03114
type: UnificationXref
id: P03114
db: PANTHER Pathway Component

uniprot P54885 6
type: UnificationXref
id: P54885
db: uniprot

uniprot P94872 10
type: UnificationXref
id: P94872
db: uniprot

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 22

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Glutamate 5-kinase
type: ProteinReference
xref: uniprot Q9WYD0 42
organism: Thermotoga maritima

STATE_TRANSITION_LEFT__pyrroline_5_carboxylate-_NADPH-RIGHT__NADP-_L_Proline-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 57
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 54
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 55
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 56
left: NADPH
left: pyrroline-5-carboxylate
interaction type: STATE_TRANSITION
right: NADP
right: L-Proline

uniprot P73071 35
type: UnificationXref
id: P73071
db: uniprot

NADPH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Proline biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__pyrroline_5_carboxylate-_NADPH-RIGHT__NADP-_L_Proline-_r4
pathway component: STATE_TRANSITION_LEFT__glutamate_5_phosphate-_NADPH-RIGHT__glutamate_semialdehyde-_NADP-_r2
pathway component: STATE_TRANSITION_LEFT__glutamate_semialdehyde-RIGHT__H2O-_pyrroline_5_carboxylate-_r3
pathway component: STATE_TRANSITION_LEFT__L_Glutamate-_ATP-RIGHT__glutamate_5_phosphate-_ADP-_r1
xref: PANTHER Pathway P02768 1
comment: MODEL_NOTES= The biosynthesis of proline an imino acid critical for protein synthesis. Website=www.biocyc.org/Ecoli/Pathways/ free text=Biochemistry (text) Voet and Voet

L-Glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Gamma-glutamyl phosphate reductase
type: ProteinReference
xref: uniprot Q9HX20 17
organism: Pseudomonas aeruginosa

uniprot P39820 34
type: UnificationXref
id: P39820
db: uniprot

Glutamate 5-kinase
type: ProteinReference
xref: uniprot P9WHU9 37
organism: Mycobacterium tuberculosis

uniprot Q9WYD0 42
type: UnificationXref
id: Q9WYD0
db: uniprot

uniprot O13810 28
type: UnificationXref
id: O13810
db: uniprot

PARTICIPANT STOICHIOMETRY r3 43
type: Stoichiometry
physical entity: glutamate semialdehyde
stoichiometric coefficient: 1.0

L-Proline
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r3 45
type: Stoichiometry
physical entity: pyrroline-5-carboxylate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 44
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 13

Pyrroline-5-carboxylate reductase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Glutamate 5-kinase 1
type: ProteinReference
xref: uniprot P39820 34
organism: Bacillus subtilis

Gamma-glutamyl phosphate reductase
type: ProteinReference
xref: uniprot P39821 4
organism: Bacillus subtilis

uniprot Q9RTD9 21
type: UnificationXref
id: Q9RTD9
db: uniprot

Gamma-glutamyl phosphate reductase
type: ProteinReference
xref: uniprot P9WHV1 12
organism: Mycobacterium tuberculosis

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 31

uniprot Q9HVL9 39
type: UnificationXref
id: Q9HVL9
db: uniprot

Glutamate 5-kinase
type: ProteinReference
xref: uniprot Q9HVL9 39
organism: Pseudomonas aeruginosa

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 18