ncbitaxon 367110 51
type: UnificationXref
id: 367110
db: ncbitaxon

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot Q9D8C9 9
xref: PTHR11904:SF12
organism: Mus musculus

Pi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r80 88
type: Stoichiometry
physical entity: NH4 +
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r80 89
type: Stoichiometry
physical entity: Inosine-5'-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r80 86
type: Stoichiometry
physical entity: H2O + H+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r80 87
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

uniprot P21588 59
type: UnificationXref
id: P21588
db: uniprot

PARTICIPANT STOICHIOMETRY r81 78
type: Stoichiometry
physical entity: GMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r81 79
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

ncbitaxon 10090 7
type: UnificationXref
id: 10090
db: ncbitaxon

Nucleoside Phosphorylase
type: ProteinReference
xref: P03115
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Nucleoside Phosphorylase Synonym: Synonym not specified Accession: P03115
comment: ENTITY_REFERENCE_ID_DESC=Purine metabolism.PROTEIN.GENERIC.Nucleoside Phosphorylase
member entity reference: Purine nucleoside phosphorylase
member entity reference: S-methyl-5'-thioinosine phosphorylase

ncbitaxon 10116 19
type: UnificationXref
id: 10116
db: ncbitaxon

Urate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__Xanthine-_H2O__PLUS__O2-RIGHT__Urate-_2H_PLUS___PLUS__O2__-_r84
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r84 63
participant stoichiometry: PARTICIPANT STOICHIOMETRY r84 65
participant stoichiometry: PARTICIPANT STOICHIOMETRY r84 62
participant stoichiometry: PARTICIPANT STOICHIOMETRY r84 64
left: H2O + O2
left: Xanthine
interaction type: STATE_TRANSITION
right: 2H+ + O2 -
right: Urate

ncbitaxon 13616 35
type: UnificationXref
id: 13616
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r83 66
type: Stoichiometry
physical entity: Guanine
stoichiometric coefficient: 1.0

Mus musculus
type: BioSource
xref: ncbitaxon 10090 7

PARTICIPANT STOICHIOMETRY r83 69
type: Stoichiometry
physical entity: Xanthine
stoichiometric coefficient: 1.0

ncbitaxon 208964 11
type: UnificationXref
id: 208964
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r83 67
type: Stoichiometry
physical entity: H2O + H+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r83 68
type: Stoichiometry
physical entity: NH4 +
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Guanosine-_Pi-RIGHT__Guanine-_Ribose_1_Phosphate-_r82
controller: Nucleoside Phosphorylase

Xanthine Oxidase
type: Protein
entity reference: Xanthine Oxidase
comment: SPECIES_TYPE=PROTEIN

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 42

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 17

AMP deaminase 3
type: ProteinReference
xref: uniprot O08739 37
xref: PTHR11359:SF2
organism: Mus musculus

uniprot P22985 18
type: UnificationXref
id: P22985
db: uniprot

STATE_TRANSITION_LEFT__GMP-_H2O-RIGHT__Guanosine-_Pi-_r81
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 78
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 79
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 81
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 80
left: GMP
left: H2O
interaction type: STATE_TRANSITION
right: Guanosine
right: Pi

uniprot Q9D8C9 9
type: UnificationXref
id: Q9D8C9
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 8

Guanine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR11908:SF130
type: RelationshipXref
id: PTHR11908:SF130
db: PANTHER Family
relationship type: By Homology

PTHR11904:SF12
type: RelationshipXref
id: PTHR11904:SF12
db: PANTHER Family
relationship type: By Homology

uniprot Q00519 27
type: UnificationXref
id: Q00519
db: uniprot

Inosine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O__PLUS__H_PLUS_-_AMP-RIGHT__NH4__PLUS_-_Inosine_5_QUOTE_SINGLE_phosphate-_r80
controller: 5'-AMP Deaminase

ncbitaxon 7227 17
type: UnificationXref
id: 7227
db: ncbitaxon

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot A0A452DJA8 2
xref: PTHR11904:SF12
organism: Bos taurus

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 51

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 35

uniprot Q12553 28
type: UnificationXref
id: Q12553
db: uniprot

ncbitaxon 559292 42
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot Q01432 43
type: UnificationXref
id: Q01432
db: uniprot

ncbitaxon 9544 13
type: UnificationXref
id: 9544
db: ncbitaxon

S-methyl-5'-thioinosine phosphorylase
type: ProteinReference
xref: PTHR42679:SF2
xref: uniprot Q9HZK1 10
organism: Pseudomonas aeruginosa

2H+ + O2 -
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZX14 12
xref: PTHR11908:SF80
organism: Macaca mulatta

AMP deaminase
type: ProteinReference
xref: uniprot F7AVX9 33
xref: PTHR11359:SF2
organism: Macaca mulatta

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot P23492 6
xref: PTHR11904:SF12
organism: Mus musculus

ncbitaxon 9913 3
type: UnificationXref
id: 9913
db: ncbitaxon

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 15

uniprot F7E5A8 34
type: UnificationXref
id: F7E5A8
db: uniprot

uniprot F7AVX9 33
type: UnificationXref
id: F7AVX9
db: uniprot

uniprot Q61503 61
type: UnificationXref
id: Q61503
db: uniprot

Guanine deaminase
type: ProteinReference
xref: uniprot Q9WTT6 55
xref: PTHR11271:SF6
organism: Rattus norvegicus

5'-Nucleotidase
type: ProteinReference
xref: P03119
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Purine metabolism.PROTEIN.GENERIC.5_super_'_endsuper_-Nucleotidase
comment: ENTITY_REFERENCE_NOTES= Long Name: 5'-Nucleotidase Synonym: Synonym not specified Accession: P03119
member entity reference: Uncharacterized protein
member entity reference: 5'-nucleotidase
member entity reference: 5'-nucleotidase ecto

Xanthine dehydrogenase/oxidase
type: ProteinReference
xref: uniprot P22985 18
xref: PTHR11908:SF80
organism: Rattus norvegicus

AMP deaminase 3
type: ProteinReference
xref: uniprot Q01432 43
xref: PTHR11359:SF2
organism: Homo sapiens

Guanine deaminase
type: ProteinReference
xref: uniprot Q1K8M4 50
organism: Neurospora crassa

Xanthine Oxidase
type: ProteinReference
xref: P03116
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Purine metabolism.PROTEIN.GENERIC.Xanthine Oxidase
comment: ENTITY_REFERENCE_NOTES= Long Name: Xanthine Oxidase Synonym: Synonym not specified Accession: P03116
member entity reference: Xanthine dehydrogenase/oxidase
member entity reference: Xanthine dehydrogenase
member entity reference: Uncharacterized protein

NH4 +
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

5'-nucleotidase
type: ProteinReference
xref: uniprot Q61503 61
xref: PTHR11575:SF25
organism: Mus musculus

Guanine Deaminase
type: Protein
entity reference: Guanine Deaminase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9606 22
type: UnificationXref
id: 9606
db: ncbitaxon

AMP deaminase
type: ProteinReference
xref: uniprot Q54DD0 46
xref: PTHR11359:SF0
organism: Dictyostelium discoideum

STATE_TRANSITION_LEFT__Guanine-_H2O__PLUS__H_PLUS_-RIGHT__NH4__PLUS_-_Xanthine-_r83
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r83 67
participant stoichiometry: PARTICIPANT STOICHIOMETRY r83 66
participant stoichiometry: PARTICIPANT STOICHIOMETRY r83 68
participant stoichiometry: PARTICIPANT STOICHIOMETRY r83 69
left: Guanine
left: H2O + H+
interaction type: STATE_TRANSITION
right: Xanthine
right: NH4 +

uniprot P15274 41
type: UnificationXref
id: P15274
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GMP-_H2O-RIGHT__Guanosine-_Pi-_r81
controller: 5'-Nucleotidase

STATE_TRANSITION_LEFT__Inosine-_Pi-RIGHT__Ribose_1_Phosphate-_Hypoxanthine-_r78
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 82
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 83
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 85
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 84
left: Inosine
left: Pi
interaction type: STATE_TRANSITION
right: Ribose 1-Phosphate
right: Hypoxanthine

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 22

uniprot H2QHQ2 14
type: UnificationXref
id: H2QHQ2
db: uniprot

STATE_TRANSITION_LEFT__Urate-_O2__-RIGHT__CO2-_Allantoin-_r85
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 97
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 94
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 95
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 96
left: O2 -
left: Urate
interaction type: STATE_TRANSITION
right: Allantoin
right: CO2

eco ECO:0000304 4
type: UnificationXref
id: ECO:0000304
db: eco

Guanine deaminase
type: ProteinReference
xref: PTHR11271:SF6
xref: uniprot Q9I6Z8 53
organism: Pseudomonas aeruginosa

Guanine deaminase
type: ProteinReference
xref: uniprot Q9Y2T3 56
xref: PTHR11271:SF6
organism: Homo sapiens

PTHR11908:SF80
type: RelationshipXref
id: PTHR11908:SF80
db: PANTHER Family
relationship type: By Homology

Xanthine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine deaminase
type: ProteinReference
xref: uniprot Q9R111 54
xref: PTHR11271:SF6
organism: Mus musculus

Purine metabolism
type: Pathway
pathway component: STATE_TRANSITION_LEFT__H2O__PLUS__H_PLUS_-_AMP-RIGHT__NH4__PLUS_-_Inosine_5_QUOTE_SINGLE_phosphate-_r80
pathway component: STATE_TRANSITION_LEFT__Inosine-_Pi-RIGHT__Ribose_1_Phosphate-_Hypoxanthine-_r78
pathway component: STATE_TRANSITION_LEFT__H2O-_Inosine_5_QUOTE_SINGLE_phosphate-RIGHT__Inosine-_Pi-_r79
pathway component: STATE_TRANSITION_LEFT__Urate-_O2__-RIGHT__CO2-_Allantoin-_r85
pathway component: STATE_TRANSITION_LEFT__GMP-_H2O-RIGHT__Guanosine-_Pi-_r81
pathway component: STATE_TRANSITION_LEFT__Guanine-_H2O__PLUS__H_PLUS_-RIGHT__NH4__PLUS_-_Xanthine-_r83
pathway component: STATE_TRANSITION_LEFT__Xanthine-_H2O__PLUS__O2-RIGHT__Urate-_2H_PLUS___PLUS__O2__-_r84
pathway component: STATE_TRANSITION_LEFT__Hypoxanthine-_H2O__PLUS__O2-RIGHT__Xanthine-_2H_PLUS___PLUS__O2__-_r86
pathway component: STATE_TRANSITION_LEFT__Guanosine-_Pi-RIGHT__Guanine-_Ribose_1_Phosphate-_r82
xref: PANTHER Pathway P02769 1
comment: MODEL_NOTES= The pattern of breakdown is very different for the two types of nucletide bases, purines and pyrimidines. In the case of pyrimidines the ring is reduced and then opened, and with the exception of beta-alanine the nitrogen is removed by deamination and transamination as ammonia, which must ultimately be converted into urea. However, in the case of purines only the amino nitrogen outside the ring is removed as ammonia. The purine ring itself is oxidized to uric acid by xanthine oxidase and excreted. In humans and primates, the conversion of urate to allantoin occurs non-enzymatically by interaction with oxygen free radicals. free text=Biochemiscal Pathways - An Atlas of Biochemistry and Molecular Biology Edited by Gerhard Michal free text=Color Atlas of Biochemistry by Jan Koolman and Klaus-Heinrich Rohm free text=Human Metabolism by Ramsey Bronk

uniprot O09178 38
type: UnificationXref
id: O09178
db: uniprot

uniprot Q1K8M4 50
type: UnificationXref
id: Q1K8M4
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 40

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Xanthine-_H2O__PLUS__O2-RIGHT__Urate-_2H_PLUS___PLUS__O2__-_r84
controller: Xanthine Oxidase

Xanthine dehydrogenase/oxidase
type: ProteinReference
xref: uniprot P80457 25
xref: PTHR11908:SF80
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r86 92
type: Stoichiometry
physical entity: Xanthine
stoichiometric coefficient: 1.0

uniprot P47989 21
type: UnificationXref
id: P47989
db: uniprot

PARTICIPANT STOICHIOMETRY r86 91
type: Stoichiometry
physical entity: H2O + O2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r86 93
type: Stoichiometry
physical entity: 2H+ + O2 -
stoichiometric coefficient: 1.0

uniprot H2Q364 36
type: UnificationXref
id: H2Q364
db: uniprot

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

5'-nucleotidase
type: ProteinReference
xref: uniprot P21588 59
xref: PTHR11575:SF25
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r78 82
type: Stoichiometry
physical entity: Inosine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r78 85
type: Stoichiometry
physical entity: Hypoxanthine
stoichiometric coefficient: 1.0

PTHR11359:SF11
type: RelationshipXref
id: PTHR11359:SF11
db: PANTHER Family
relationship type: By Homology

5'-nucleotidase
type: ProteinReference
xref: PTHR11575:SF25
xref: uniprot P21589 60
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r78 84
type: Stoichiometry
physical entity: Ribose 1-Phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r78 83
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

uniprot O80452 39
type: UnificationXref
id: O80452
db: uniprot

Ribose 1-Phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9HZK1 10
type: UnificationXref
id: Q9HZK1
db: uniprot

PARTICIPANT STOICHIOMETRY r84 65
type: Stoichiometry
physical entity: 2H+ + O2 -
stoichiometric coefficient: 1.0

ncbitaxon 44689 47
type: UnificationXref
id: 44689
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r84 64
type: Stoichiometry
physical entity: Urate
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR11575:SF25
xref: uniprot A0A1D5Q656 57
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r84 63
type: Stoichiometry
physical entity: H2O + O2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r84 62
type: Stoichiometry
physical entity: Xanthine
stoichiometric coefficient: 1.0

ncbitaxon 3702 40
type: UnificationXref
id: 3702
db: ncbitaxon

Guanine deaminase
type: ProteinReference
xref: PTHR11271:SF6
xref: uniprot F7CWR5 49
organism: Macaca mulatta

uniprot E2R740 31
type: UnificationXref
id: E2R740
db: uniprot

GMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O08739 37
type: UnificationXref
id: O08739
db: uniprot

PARTICIPANT STOICHIOMETRY r81 81
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r86 90
type: Stoichiometry
physical entity: Hypoxanthine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r81 80
type: Stoichiometry
physical entity: Guanosine
stoichiometric coefficient: 1.0

IDA
type: EvidenceCodeVocabulary

eco ECO:0000250 8
type: UnificationXref
id: ECO:0000250
db: eco

Xanthine dehydrogenase
type: ProteinReference
xref: uniprot P10351 16
xref: PTHR11908:SF100
organism: Drosophila melanogaster

Guanine Deaminase
type: ProteinReference
xref: P03118
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Purine metabolism.PROTEIN.GENERIC.Guanine Deaminase
comment: ENTITY_REFERENCE_NOTES= Long Name: Guanine Deaminase Synonym: Synonym not specified Accession: P03118
member entity reference: Guanine deaminase

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 47

Bos taurus
type: BioSource
xref: ncbitaxon 9913 3

O2 -
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 13

ncbitaxon 5664 45
type: UnificationXref
id: 5664
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r82 71
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r82 72
type: Stoichiometry
physical entity: Guanine
stoichiometric coefficient: 1.0

5'-AMP Deaminase
type: Protein
entity reference: 5'-AMP Deaminase
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r82 70
type: Stoichiometry
physical entity: Guanosine
stoichiometric coefficient: 1.0

5'-Nucleotidase
type: Protein
entity reference: 5'-Nucleotidase
comment: SPECIES_TYPE=PROTEIN

uniprot Q9I6Z8 53
type: UnificationXref
id: Q9I6Z8
db: uniprot

NAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000303 26

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 4

By Homology
type: RelationshipTypeVocabulary

Xanthine dehydrogenase
type: ProteinReference
xref: uniprot H2QHQ2 14
xref: PTHR11908:SF80
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r82 73
type: Stoichiometry
physical entity: Ribose 1-Phosphate
stoichiometric coefficient: 1.0

AMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F6ZX14 12
type: UnificationXref
id: F6ZX14
db: uniprot

STATE_TRANSITION_LEFT__Hypoxanthine-_H2O__PLUS__O2-RIGHT__Xanthine-_2H_PLUS___PLUS__O2__-_r86
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 91
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 90
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 92
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 93
left: H2O + O2
left: Hypoxanthine
interaction type: STATE_TRANSITION
right: 2H+ + O2 -
right: Xanthine

ncbitaxon 9598 15
type: UnificationXref
id: 9598
db: ncbitaxon

STATE_TRANSITION_LEFT__H2O__PLUS__H_PLUS_-_AMP-RIGHT__NH4__PLUS_-_Inosine_5_QUOTE_SINGLE_phosphate-_r80
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 86
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 87
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 89
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 88
left: AMP
left: H2O + H+
interaction type: STATE_TRANSITION
right: Inosine-5'-phosphate
right: NH4 +

ncbitaxon 9615 32
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot P23492 6
type: UnificationXref
id: P23492
db: uniprot

AMP deaminase
type: ProteinReference
xref: uniprot F7E5A8 34
xref: PTHR11359:SF2
organism: Monodelphis domestica

H2O + O2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A1D5Q656 57
type: UnificationXref
id: A0A1D5Q656
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 19

Guanosine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9R111 54
type: UnificationXref
id: Q9R111
db: uniprot

5'-AMP Deaminase
type: ProteinReference
xref: P03117
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Purine metabolism.PROTEIN.GENERIC.5_super_'_endsuper_-AMP Deaminase
comment: ENTITY_REFERENCE_NOTES= Long Name: 5'-AMP Deaminase Synonym: Synonym not specified Accession: P03117
member entity reference: AMP deaminase
member entity reference: AMP deaminase 3
member entity reference: Adenosine monophosphate deaminase 3
member entity reference: Putative AMP deaminase

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 32

PARTICIPANT STOICHIOMETRY r85 97
type: Stoichiometry
physical entity: Allantoin
stoichiometric coefficient: 1.0

uniprot P80457 25
type: UnificationXref
id: P80457
db: uniprot

PARTICIPANT STOICHIOMETRY r85 96
type: Stoichiometry
physical entity: CO2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r85 95
type: Stoichiometry
physical entity: O2 -
stoichiometric coefficient: 1.0

uniprot Q9Y2T3 56
type: UnificationXref
id: Q9Y2T3
db: uniprot

PARTICIPANT STOICHIOMETRY r85 94
type: Stoichiometry
physical entity: Urate
stoichiometric coefficient: 1.0

Allantoin
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Guanine-_H2O__PLUS__H_PLUS_-RIGHT__NH4__PLUS_-_Xanthine-_r83
controller: Guanine Deaminase

uniprot A0A452DJA8 2
type: UnificationXref
id: A0A452DJA8
db: uniprot

Guanine deaminase
type: ProteinReference
xref: PTHR11271:SF6
xref: uniprot Q9I3J2 52
organism: Pseudomonas aeruginosa

AMP deaminase 3
type: ProteinReference
xref: uniprot O09178 38
xref: PTHR11359:SF2
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r79 77
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

Xanthine dehydrogenase/oxidase
type: ProteinReference
xref: uniprot Q00519 27
xref: PTHR11908:SF80
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r79 76
type: Stoichiometry
physical entity: Inosine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r79 75
type: Stoichiometry
physical entity: Inosine-5'-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r79 74
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 24

AMP deaminase
type: ProteinReference
xref: PTHR11359:SF0
xref: uniprot P15274 41
organism: Saccharomyces cerevisiae

uniprot F7CWR5 49
type: UnificationXref
id: F7CWR5
db: uniprot

PTHR42679:SF2
type: RelationshipXref
id: PTHR42679:SF2
db: PANTHER Family
relationship type: By Homology

uniprot H2QTC9 58
type: UnificationXref
id: H2QTC9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Inosine-_Pi-RIGHT__Ribose_1_Phosphate-_Hypoxanthine-_r78
controller: Nucleoside Phosphorylase

PANTHER Pathway P02769 1
type: UnificationXref
id: P02769
db: PANTHER Pathway

STATE_TRANSITION
type: InteractionVocabulary

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION_LEFT__Guanosine-_Pi-RIGHT__Guanine-_Ribose_1_Phosphate-_r82
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 71
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 73
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 72
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 70
left: Guanosine
left: Pi
interaction type: STATE_TRANSITION
right: Guanine
right: Ribose 1-Phosphate

Inosine-5'-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_Inosine_5_QUOTE_SINGLE_phosphate-RIGHT__Inosine-_Pi-_r79
controller: 5'-Nucleotidase

Hypoxanthine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9WTT6 55
type: UnificationXref
id: Q9WTT6
db: uniprot

uniprot Q9I3J2 52
type: UnificationXref
id: Q9I3J2
db: uniprot

uniprot P47990 23
type: UnificationXref
id: P47990
db: uniprot

P03115
type: UnificationXref
id: P03115
db: PANTHER Pathway Component

uniprot Q54DD0 46
type: UnificationXref
id: Q54DD0
db: uniprot

P03116
type: UnificationXref
id: P03116
db: PANTHER Pathway Component

H2O + H+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__H2O-_Inosine_5_QUOTE_SINGLE_phosphate-RIGHT__Inosine-_Pi-_r79
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 77
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 74
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 76
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 75
left: Inosine-5'-phosphate
left: H2O
interaction type: STATE_TRANSITION
right: Inosine
right: Pi

Putative AMP deaminase
type: ProteinReference
xref: uniprot Q4QG56 44
xref: PTHR11359:SF0
organism: Leishmania major

Leishmania major
type: BioSource
xref: ncbitaxon 5664 45

Guanine deaminase
type: ProteinReference
xref: uniprot A0A2I3S7K0 48
xref: PTHR11271:SF6
organism: Pan troglodytes

P03119
type: UnificationXref
id: P03119
db: PANTHER Pathway Component

P03118
type: UnificationXref
id: P03118
db: PANTHER Pathway Component

PTHR11575:SF25
type: RelationshipXref
id: PTHR11575:SF25
db: PANTHER Family
relationship type: By Homology

P03117
type: UnificationXref
id: P03117
db: PANTHER Pathway Component

Xanthine dehydrogenase
type: ProteinReference
xref: PTHR11908:SF130
xref: uniprot Q12553 28
organism: Emericella nidulans

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Hypoxanthine-_H2O__PLUS__O2-RIGHT__Xanthine-_2H_PLUS___PLUS__O2__-_r86
controller: Xanthine Oxidase

eco ECO:0000303 26
type: UnificationXref
id: ECO:0000303
db: eco

CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR11271:SF6
type: RelationshipXref
id: PTHR11271:SF6
db: PANTHER Family
relationship type: By Homology

uniprot P21589 60
type: UnificationXref
id: P21589
db: uniprot

AMP deaminase
type: ProteinReference
xref: PTHR11359:SF11
xref: uniprot O80452 39
organism: Arabidopsis thaliana

5'-nucleotidase ecto
type: ProteinReference
xref: PTHR11575:SF25
xref: uniprot H2QTC9 58
organism: Pan troglodytes

uniprot E1BA23 30
type: UnificationXref
id: E1BA23
db: uniprot

Nucleoside Phosphorylase
type: Protein
entity reference: Nucleoside Phosphorylase
comment: SPECIES_TYPE=PROTEIN

Xanthine dehydrogenase/oxidase
type: ProteinReference
xref: uniprot P47989 21
xref: PTHR11908:SF80
organism: Homo sapiens

ncbitaxon 227321 29
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot Q4QG56 44
type: UnificationXref
id: Q4QG56
db: uniprot

AMP deaminase
type: ProteinReference
xref: PTHR11359:SF2
xref: uniprot E2R740 31
organism: Canis lupus familiaris

AMP deaminase
type: ProteinReference
xref: uniprot H2Q364 36
xref: PTHR11359:SF2
organism: Pan troglodytes

uniprot A0A2I3S7K0 48
type: UnificationXref
id: A0A2I3S7K0
db: uniprot

Xanthine dehydrogenase/oxidase
type: ProteinReference
xref: uniprot P47990 23
xref: PTHR11908:SF80
organism: Gallus gallus

uniprot P10351 16
type: UnificationXref
id: P10351
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 29

PTHR11908:SF100
type: RelationshipXref
id: PTHR11908:SF100
db: PANTHER Family
relationship type: By Homology

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 11

ncbitaxon 9031 24
type: UnificationXref
id: 9031
db: ncbitaxon

PTHR11359:SF0
type: RelationshipXref
id: PTHR11359:SF0
db: PANTHER Family
relationship type: By Homology

Adenosine monophosphate deaminase 3
type: ProteinReference
xref: uniprot E1BA23 30
xref: PTHR11359:SF2
organism: Bos taurus

PTHR11359:SF2
type: RelationshipXref
id: PTHR11359:SF2
db: PANTHER Family
relationship type: By Homology