uniprot Q9X7W3 99
type: UnificationXref
id: Q9X7W3
db: uniprot

NAD
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P54523 83
type: UnificationXref
id: P54523
db: uniprot

Pyridoxamine 5'-phosphate oxidase
type: ProteinReference
xref: uniprot E2QTE2 54
xref: PTHR10851:SF0
organism: Canis lupus familiaris

Phosphoserine aminotransferase
type: ProteinReference
xref: uniprot Q803I7 32
organism: Danio rerio

glyceraldehyde-3-phosphate pyruvate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot Q9X291 97
organism: Thermotoga maritima

ncbitaxon 8364 9
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot Q9LFL9 95
type: UnificationXref
id: Q9LFL9
db: uniprot

Probable pyridoxamine 5'-phosphate oxidase
type: ProteinReference
xref: uniprot Q9UTQ1 73
xref: PTHR10851:SF0
organism: Schizosaccharomyces pombe

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 25

ncbitaxon 243274 98
type: UnificationXref
id: 243274
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__1_deoxy_D_xylulose_5_phosphate-_amino_propan_2_one_3_phosphate-RIGHT__pyridoxine_5_phosphate-_r5
controller: Pyridoxine-5-phosphate synthase

uniprot Q38854 87
type: UnificationXref
id: Q38854
db: uniprot

ncbitaxon 226186 35
type: UnificationXref
id: 226186
db: ncbitaxon

4-Hydroxythreonine-4-phosphate dehydrogenase
type: Protein
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9598 57
type: UnificationXref
id: 9598
db: ncbitaxon

Erythronate-4-phosphate dehydrogenase
type: ProteinReference
xref: uniprot Q9I3W9 51
organism: Pseudomonas aeruginosa

ncbitaxon 5759 27
type: UnificationXref
id: 5759
db: ncbitaxon

Phosphoserine aminotransferase
type: ProteinReference
xref: uniprot A0A0G2K931 2
xref: PTHR43247:SF1
organism: Rattus norvegicus

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 82

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 98

Mus musculus
type: BioSource
xref: ncbitaxon 10090 43

Phosphoserine aminotransferase
type: ProteinReference
xref: PTHR43247:SF1
xref: uniprot P23721 14
organism: Escherichia coli

Pyridoxine-5'-phosphate oxidase
type: ProteinReference
xref: PTHR10851:SF0
xref: uniprot A0A1D5Q928 53
organism: Macaca mulatta

Probable phosphoserine aminotransferase
type: ProteinReference
xref: uniprot P91856 20
organism: Caenorhabditis elegans

STATE_TRANSITION_LEFT__erythrose_4_phosphate-_H2O-_NAD-RIGHT__erythronate_4_phosphate-_NADH-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 109
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 111
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 110
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 108
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 112
left: NAD
left: H2O
left: erythrose-4-phosphate
interaction type: STATE_TRANSITION
right: NADH
right: erythronate-4-phosphate

Phosphohydroxythreonine aminotransferase
type: Protein
entity reference: Phosphohydroxythreonine aminotransferase
comment: SPECIES_TYPE=PROTEIN

Phosphoserine aminotransferase
type: ProteinReference
xref: uniprot Q5TRW7 24
organism: Anopheles gambiae

uniprot P74211 60
type: UnificationXref
id: P74211
db: uniprot

Pyridoxine-5'-phosphate oxidase
type: ProteinReference
xref: uniprot Q91XF0 66
xref: PTHR10851:SF0
organism: Mus musculus

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 17

uniprot P80862 18
type: UnificationXref
id: P80862
db: uniprot

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 61

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 48

uniprot O50408 76
type: UnificationXref
id: O50408
db: uniprot

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 27

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 4

Erythrose-4-phosphate dehydrogenase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q8CJP7 88
type: UnificationXref
id: Q8CJP7
db: uniprot

Phosphoserine aminotransferase
type: ProteinReference
xref: uniprot P33330 16
xref: PTHR43247:SF1
organism: Saccharomyces cerevisiae

uniprot Q5TRW7 24
type: UnificationXref
id: Q5TRW7
db: uniprot

uniprot A8Y1C7 10
type: UnificationXref
id: A8Y1C7
db: uniprot

Pyridoxine/pyridoxamine 5'-phosphate oxidase
type: ProteinReference
xref: uniprot Q9K3V7 68
xref: PTHR10851:SF0
organism: Streptomyces coelicolor

uniprot P33330 16
type: UnificationXref
id: P33330
db: uniprot

uniprot Q9UTQ1 73
type: UnificationXref
id: Q9UTQ1
db: uniprot

Phosphoserine aminotransferase
type: ProteinReference
xref: uniprot Q8TNI1 38
organism: Methanosarcina acetivorans

STATE_TRANSITION_LEFT__erythronate_4_phosphate-_NAD-RIGHT__NADH-_3_hydroxy_4_phospho_hydroxy_ketobutryate-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 107
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 106
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 104
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 105
left: NAD
left: erythronate-4-phosphate
interaction type: STATE_TRANSITION
right: 3-hydroxy-4-phospho-hydroxy-ketobutryate
right: NADH

ncbitaxon 190304 92
type: UnificationXref
id: 190304
db: ncbitaxon

Phosphoserine aminotransferase
type: ProteinReference
xref: uniprot Q9F2Y1 44
organism: Streptomyces coelicolor

uniprot P23721 14
type: UnificationXref
id: P23721
db: uniprot

pyridoxal-5-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__pyridoxine_5_phosphate-_O2-RIGHT__H2O2-_pyridoxal_5_phosphate-_r6
controller: Pyridoxine-5-phosphate oxidase

Phosphoserine aminotransferase
type: ProteinReference
xref: uniprot Q8A8L4 34
organism: Bacteroides thetaiotaomicron

1-deoxy-D-xylulose-5-phosphate synthase 1
type: ProteinReference
xref: uniprot Q9X7W3 99
organism: Streptomyces coelicolor

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 29

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 90

ncbitaxon 3702 41
type: UnificationXref
id: 3702
db: ncbitaxon

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 35

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__erythrose_4_phosphate-_H2O-_NAD-RIGHT__erythronate_4_phosphate-_NADH-_r1
controller: Erythrose-4-phosphate dehydrogenase

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot Q9KGU7 94
organism: Pseudomonas aeruginosa

uniprot A0JPC0 8
type: UnificationXref
id: A0JPC0
db: uniprot

ncbitaxon 36329 90
type: UnificationXref
id: 36329
db: ncbitaxon

uniprot Q9SHP0 46
type: UnificationXref
id: Q9SHP0
db: uniprot

uniprot Q5E9K3 64
type: UnificationXref
id: Q5E9K3
db: uniprot

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot O84335 81
organism: Chlamydia trachomatis

NADH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 83332 63
type: UnificationXref
id: 83332
db: ncbitaxon

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 23

ncbitaxon 100226 45
type: UnificationXref
id: 100226
db: ncbitaxon

uniprot P38075 59
type: UnificationXref
id: P38075
db: uniprot

uniprot Q91XF0 66
type: UnificationXref
id: Q91XF0
db: uniprot

ncbitaxon 7955 33
type: UnificationXref
id: 7955
db: ncbitaxon

ncbitaxon 10090 43
type: UnificationXref
id: 10090
db: ncbitaxon

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot P77488 85
organism: Escherichia coli

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 57

1-deoxy-D-xylulose 5-phosphate synthase
type: ProteinReference
xref: uniprot Q8IDW0 89
organism: Plasmodium falciparum

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 9

ncbitaxon 559292 17
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot Q9KGU7 94
type: UnificationXref
id: Q9KGU7
db: uniprot

Putative phosphoserine aminotransferase
type: ProteinReference
xref: uniprot Q10349 22
organism: Schizosaccharomyces pombe

uniprot Q9K3V7 68
type: UnificationXref
id: Q9K3V7
db: uniprot

Phosphohydroxythreonine aminotransferase
type: ProteinReference
xref: P03058
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Pyridoxal-5-phosphate biosynthesis.PROTEIN.GENERIC.Phosphohydroxythreonine_br_aminotransferase
comment: ENTITY_REFERENCE_NOTES= Long Name: Phosphohydroxythreonine aminotransferase Synonym: Synonym not specified Accession: P03058
member entity reference: Phosphoserine aminotransferase
member entity reference: Probable phosphoserine aminotransferase
member entity reference: Phosphoserine aminotransferase 1, chloroplastic
member entity reference: Putative phosphoserine aminotransferase
member entity reference: Phosphoserine aminotransferase 2, chloroplastic

Pyridoxine-5-phosphate synthase
type: Protein
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 224324 78
type: UnificationXref
id: 224324
db: ncbitaxon

STATE_TRANSITION_LEFT__pyridoxine_5_phosphate-_O2-RIGHT__H2O2-_pyridoxal_5_phosphate-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 119
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 117
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 120
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 118
left: O2
left: pyridoxine-5-phosphate
interaction type: STATE_TRANSITION
right: pyridoxal-5-phosphate
right: H2O2

PTHR43247:SF5
type: RelationshipXref
id: PTHR43247:SF5
db: PANTHER Family
relationship type: By Homology

ncbitaxon 1111708 61
type: UnificationXref
id: 1111708
db: ncbitaxon

PTHR43247:SF3
type: RelationshipXref
id: PTHR43247:SF3
db: PANTHER Family
relationship type: By Homology

ncbitaxon 272561 82
type: UnificationXref
id: 272561
db: ncbitaxon

PTHR43247:SF1
type: RelationshipXref
id: PTHR43247:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q9Y617 49
type: UnificationXref
id: Q9Y617
db: uniprot

uniprot A0A3S5ZPF7 6
type: UnificationXref
id: A0A3S5ZPF7
db: uniprot

STATE_TRANSITION_LEFT__glyceraldehyde_3_phosphate_pyruvate-_Pyruvate-RIGHT__1_deoxy_D_xylulose_5_phosphate-_CO2-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 115
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 114
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 113
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 116
left: glyceraldehyde-3-phosphate pyruvate
left: Pyruvate
interaction type: STATE_TRANSITION
right: 1-deoxy-D-xylulose-5-phosphate
right: CO2

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 37

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 72

Pyridoxine/pyridoxamine 5'-phosphate oxidase
type: ProteinReference
xref: PTHR10851:SF0
xref: uniprot P74211 60
organism: Synechocystis

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 50

uniprot Q8R639 93
type: UnificationXref
id: Q8R639
db: uniprot

1-Deoxyxylulose-5-phosphate synthase
type: Protein
entity reference: 1-Deoxyxylulose-5-phosphate synthase
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__glutamate-_3_hydroxy_4_phospho_hydroxy_ketobutryate-RIGHT__ketoglutarate-_phospho_hydroxy_threonine-_r3
controller: Phosphohydroxythreonine aminotransferase

uniprot O84335 81
type: UnificationXref
id: O84335
db: uniprot

P03059
type: UnificationXref
id: P03059
db: PANTHER Pathway Component

P03058
type: UnificationXref
id: P03058
db: PANTHER Pathway Component

amino-propan-2-one-3-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r7 116
type: Stoichiometry
physical entity: CO2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 114
type: Stoichiometry
physical entity: Pyruvate
stoichiometric coefficient: 1.0

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 41

PARTICIPANT STOICHIOMETRY r7 115
type: Stoichiometry
physical entity: 1-deoxy-D-xylulose-5-phosphate
stoichiometric coefficient: 1.0

uniprot Q99K85 42
type: UnificationXref
id: Q99K85
db: uniprot

Pyridoxine-5-phosphate oxidase
type: Protein
entity reference: Pyridoxine-5-phosphate oxidase
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r7 113
type: Stoichiometry
physical entity: glyceraldehyde-3-phosphate pyruvate
stoichiometric coefficient: 1.0

uniprot Q60I38 26
type: UnificationXref
id: Q60I38
db: uniprot

1-deoxy-D-xylulose-5-phosphate synthase 2
type: ProteinReference
xref: uniprot Q8CJP7 88
organism: Streptomyces coelicolor

PARTICIPANT STOICHIOMETRY r6 120
type: Stoichiometry
physical entity: pyridoxal-5-phosphate
stoichiometric coefficient: 1.0

ncbitaxon 7227 48
type: UnificationXref
id: 7227
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r5 123
type: Stoichiometry
physical entity: pyridoxine-5-phosphate
stoichiometric coefficient: 1.0

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 63

PARTICIPANT STOICHIOMETRY r5 121
type: Stoichiometry
physical entity: 1-deoxy-D-xylulose-5-phosphate
stoichiometric coefficient: 1.0

1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic
type: ProteinReference
xref: uniprot Q38854 87
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r5 122
type: Stoichiometry
physical entity: amino-propan-2-one-3-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 118
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 117
type: Stoichiometry
physical entity: pyridoxine-5-phosphate
stoichiometric coefficient: 1.0

uniprot Q7RWH9 28
type: UnificationXref
id: Q7RWH9
db: uniprot

PARTICIPANT STOICHIOMETRY r6 119
type: Stoichiometry
physical entity: H2O2
stoichiometric coefficient: 1.0

Pyridoxal-5-phosphate biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__erythrose_4_phosphate-_H2O-_NAD-RIGHT__erythronate_4_phosphate-_NADH-_r1
pathway component: STATE_TRANSITION_LEFT__glutamate-_3_hydroxy_4_phospho_hydroxy_ketobutryate-RIGHT__ketoglutarate-_phospho_hydroxy_threonine-_r3
pathway component: STATE_TRANSITION_LEFT__1_deoxy_D_xylulose_5_phosphate-_amino_propan_2_one_3_phosphate-RIGHT__pyridoxine_5_phosphate-_r5
pathway component: STATE_TRANSITION_LEFT__glyceraldehyde_3_phosphate_pyruvate-_Pyruvate-RIGHT__1_deoxy_D_xylulose_5_phosphate-_CO2-_r7
pathway component: STATE_TRANSITION_LEFT__erythronate_4_phosphate-_NAD-RIGHT__NADH-_3_hydroxy_4_phospho_hydroxy_ketobutryate-_r2
pathway component: STATE_TRANSITION_LEFT__phospho_hydroxy_threonine-_NAD-RIGHT__amino_propan_2_one_3_phosphate-_NADH-_CO2-_r4
pathway component: STATE_TRANSITION_LEFT__pyridoxine_5_phosphate-_O2-RIGHT__H2O2-_pyridoxal_5_phosphate-_r6
xref: PANTHER Pathway P02759 1
comment: MODEL_NOTES= The biosynthesis of the enzyme cofactor pyridoxal-5-phosphate (PLP). PLP is versatile cofactor that is involved in a number of transamination, decarboxylation, synthetic and elimination reactions in metabolism. Website=www.biocyc.org/Ecoli/Pathways/ free text=Voet and Voet (textbook) Biochemistry

Danio rerio
type: BioSource
xref: ncbitaxon 7955 33

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 15

Probable phosphoserine aminotransferase
type: ProteinReference
xref: uniprot Q9VAN0 47
organism: Drosophila melanogaster

Phosphoserine aminotransferase
type: ProteinReference
xref: PTHR43247:SF5
xref: uniprot Q9Y617 49
organism: Homo sapiens

ncbitaxon 9606 50
type: UnificationXref
id: 9606
db: ncbitaxon

ncbitaxon 243230 72
type: UnificationXref
id: 243230
db: ncbitaxon

uniprot A0A1D5Q928 53
type: UnificationXref
id: A0A1D5Q928
db: uniprot

PARTICIPANT STOICHIOMETRY r3 103
type: Stoichiometry
physical entity: phospho-hydroxy-threonine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 101
type: Stoichiometry
physical entity: 3-hydroxy-4-phospho-hydroxy-ketobutryate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 102
type: Stoichiometry
physical entity: ketoglutarate
stoichiometric coefficient: 1.0

uniprot Q10349 22
type: UnificationXref
id: Q10349
db: uniprot

Phosphoserine aminotransferase
type: ProteinReference
xref: PTHR43247:SF1
xref: uniprot P80862 18
organism: Bacillus subtilis

PARTICIPANT STOICHIOMETRY r3 100
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

uniprot Q9I3W9 51
type: UnificationXref
id: Q9I3W9
db: uniprot

ncbitaxon 188937 39
type: UnificationXref
id: 188937
db: ncbitaxon

STATE_TRANSITION_LEFT__glutamate-_3_hydroxy_4_phospho_hydroxy_ketobutryate-RIGHT__ketoglutarate-_phospho_hydroxy_threonine-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 102
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 100
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 103
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 101
left: 3-hydroxy-4-phospho-hydroxy-ketobutryate
left: glutamate
interaction type: STATE_TRANSITION
right: phospho-hydroxy-threonine
right: ketoglutarate

Phosphoserine aminotransferase
type: ProteinReference
xref: PTHR43247:SF1
xref: uniprot A0A3S5ZPF7 6
organism: Bos taurus

phospho-hydroxy-threonine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 6238 11
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot E2QTE2 54
type: UnificationXref
id: E2QTE2
db: uniprot

glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8TNI1 38
type: UnificationXref
id: Q8TNI1
db: uniprot

ncbitaxon 83333 15
type: UnificationXref
id: 83333
db: ncbitaxon

PNPO isoform 1
type: ProteinReference
xref: uniprot H2QDB2 56
xref: PTHR10851:SF0
organism: Pan troglodytes

By Homology
type: RelationshipTypeVocabulary

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot Q8R606 91
organism: Fusobacterium nucleatum

uniprot Q8R606 91
type: UnificationXref
id: Q8R606
db: uniprot

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 19

uniprot O67036 77
type: UnificationXref
id: O67036
db: uniprot

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 92

O2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Pyridoxine/pyridoxamine 5'-phosphate oxidase
type: ProteinReference
xref: PTHR10851:SF0
xref: uniprot P0AFI7 58
organism: Escherichia coli

PANTHER Pathway P02759 1
type: UnificationXref
id: P02759
db: PANTHER Pathway

Bos taurus
type: BioSource
xref: ncbitaxon 9913 7

Pyridoxine-5'-phosphate oxidase
type: ProteinReference
xref: uniprot Q5E9K3 64
xref: PTHR10851:SF0
organism: Bos taurus

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 13

PARTICIPANT STOICHIOMETRY r2 105
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 104
type: Stoichiometry
physical entity: erythronate-4-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 106
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 107
type: Stoichiometry
physical entity: 3-hydroxy-4-phospho-hydroxy-ketobutryate
stoichiometric coefficient: 1.0

Pyridoxamine 5'-phosphate oxidase
type: ProteinReference
xref: uniprot P38075 59
xref: PTHR10851:SF0
organism: Saccharomyces cerevisiae

uniprot Q9LTX3 69
type: UnificationXref
id: Q9LTX3
db: uniprot

Pyridoxine/pyridoxamine 5'-phosphate oxidase
type: ProteinReference
xref: PTHR10851:SF0
xref: uniprot Q9RX20 71
organism: Deinococcus radiodurans

uniprot Q8IDW0 89
type: UnificationXref
id: Q8IDW0
db: uniprot

PTHR10851:SF0
type: RelationshipXref
id: PTHR10851:SF0
db: PANTHER Family
relationship type: By Homology

P03061
type: UnificationXref
id: P03061
db: PANTHER Pathway Component

P03062
type: UnificationXref
id: P03062
db: PANTHER Pathway Component

uniprot Q9NVS9 70
type: UnificationXref
id: Q9NVS9
db: uniprot

ncbitaxon 9615 55
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot Q9X291 97
type: UnificationXref
id: Q9X291
db: uniprot

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot O81954 79
organism: Chlamydomonas reinhardtii

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 39

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot P73067 84
organism: Synechocystis

Os06g0142900 protein
type: ProteinReference
xref: uniprot A0A0P0WSV0 74
organism: Oryza sativa

Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs2 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS)
type: ProteinReference
xref: uniprot O50408 76
organism: Mycobacterium tuberculosis

Pyridoxine/pyridoxamine 5'-phosphate oxidase
type: ProteinReference
xref: PTHR10851:SF0
xref: uniprot Q9I4S5 67
organism: Pseudomonas aeruginosa

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 3

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 78

ncbitaxon 243090 31
type: UnificationXref
id: 243090
db: ncbitaxon

STATE_TRANSITION_LEFT__phospho_hydroxy_threonine-_NAD-RIGHT__amino_propan_2_one_3_phosphate-_NADH-_CO2-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 126
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 128
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 124
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 125
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 127
left: NAD
left: phospho-hydroxy-threonine
interaction type: STATE_TRANSITION
right: NADH
right: CO2
right: amino-propan-2-one-3-phosphate

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 55

erythrose-4-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 224308 19
type: UnificationXref
id: 224308
db: ncbitaxon

Pyridoxine 5'-phosphate oxidase
type: ProteinReference
xref: uniprot P9WIJ1 62
xref: PTHR10851:SF0
organism: Mycobacterium tuberculosis

uniprot Q8A8L4 34
type: UnificationXref
id: Q8A8L4
db: uniprot

ncbitaxon 10116 3
type: UnificationXref
id: 10116
db: ncbitaxon

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot Q8R639 93
organism: Fusobacterium nucleatum

ncbitaxon 189518 37
type: UnificationXref
id: 189518
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phospho_hydroxy_threonine-_NAD-RIGHT__amino_propan_2_one_3_phosphate-_NADH-_CO2-_r4
controller: 4-Hydroxythreonine-4-phosphate dehydrogenase

uniprot P91856 20
type: UnificationXref
id: P91856
db: uniprot

uniprot O81954 79
type: UnificationXref
id: O81954
db: uniprot

ncbitaxon 39947 75
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot Q7UQL3 30
type: UnificationXref
id: Q7UQL3
db: uniprot

Phosphoserine aminotransferase 1, chloroplastic
type: ProteinReference
xref: PTHR43247:SF3
xref: uniprot Q96255 40
organism: Arabidopsis thaliana

Phosphoserine aminotransferase
type: ProteinReference
xref: uniprot F7H2J8 12
xref: PTHR43247:SF1
organism: Macaca mulatta

eco ECO:0000250 4
type: UnificationXref
id: ECO:0000250
db: eco

H2O2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P73067 84
type: UnificationXref
id: P73067
db: uniprot

ncbitaxon 367110 29
type: UnificationXref
id: 367110
db: ncbitaxon

ncbitaxon 7165 25
type: UnificationXref
id: 7165
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r1 108
type: Stoichiometry
physical entity: erythrose-4-phosphate
stoichiometric coefficient: 1.0

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 31

PARTICIPANT STOICHIOMETRY r1 109
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 45

uniprot P9WNS3 86
type: UnificationXref
id: P9WNS3
db: uniprot

CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Phosphoserine aminotransferase
type: ProteinReference
xref: uniprot Q60I38 26
organism: Entamoeba histolytica

uniprot A0A0G2K931 2
type: UnificationXref
id: A0A0G2K931
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

1-D-deoxyxylulose 5-phosphate synthase-like protein
type: ProteinReference
xref: uniprot Q9LFL9 95
organism: Arabidopsis thaliana

Pyruvate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9913 7
type: UnificationXref
id: 9913
db: ncbitaxon

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 80

1-Deoxyxylulose-5-phosphate synthase
type: ProteinReference
xref: P03062
comment: ENTITY_REFERENCE_ID_DESC=Pyridoxal-5-phosphate biosynthesis.PROTEIN.GENERIC.1-Deoxyxylulose-5-_br_phosphate synthase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: 1-Deoxyxylulose-5-phosphate synthase Synonym: Synonym not specified Accession: P03062
member entity reference: 1-deoxy-D-xylulose 5-phosphate synthase
member entity reference: 1-deoxy-D-xylulose-5-phosphate synthase
member entity reference: 1-D-deoxyxylulose 5-phosphate synthase-like protein
member entity reference: 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic
member entity reference: Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs2 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS)
member entity reference: Os06g0142900 protein
member entity reference: 1-deoxy-D-xylulose-5-phosphate synthase 1
member entity reference: 1-deoxy-D-xylulose-5-phosphate synthase 2

Pyridoxine/pyridoxamine 5'-phosphate oxidase 1, chloroplastic
type: ProteinReference
xref: uniprot Q9LTX3 69
organism: Arabidopsis thaliana

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

AGAP002227-PA
type: ProteinReference
xref: uniprot Q7QK95 65
organism: Anopheles gambiae

uniprot Q9I4S5 67
type: UnificationXref
id: Q9I4S5
db: uniprot

erythronate-4-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Phosphoserine aminotransferase
type: ProteinReference
xref: uniprot A0JPC0 8
organism: Xenopus tropicalis

ncbitaxon 208964 52
type: UnificationXref
id: 208964
db: ncbitaxon

uniprot P0AFI7 58
type: UnificationXref
id: P0AFI7
db: uniprot

uniprot Q803I7 32
type: UnificationXref
id: Q803I7
db: uniprot

ncbitaxon 6239 21
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot Q7QK95 65
type: UnificationXref
id: Q7QK95
db: uniprot

uniprot H2QDB2 56
type: UnificationXref
id: H2QDB2
db: uniprot

ncbitaxon 3055 80
type: UnificationXref
id: 3055
db: ncbitaxon

uniprot Q9VAN0 47
type: UnificationXref
id: Q9VAN0
db: uniprot

ncbitaxon 284812 23
type: UnificationXref
id: 284812
db: ncbitaxon

Phosphoserine aminotransferase
type: ProteinReference
xref: uniprot A8Y1C7 10
organism: Caenorhabditis briggsae

Phosphoserine aminotransferase 2, chloroplastic
type: ProteinReference
xref: uniprot Q9SHP0 46
organism: Arabidopsis thaliana

Phosphoserine aminotransferase
type: ProteinReference
xref: uniprot Q7UQL3 30
organism: Rhodopirellula baltica

PARTICIPANT STOICHIOMETRY r4 128
type: Stoichiometry
physical entity: CO2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 126
type: Stoichiometry
physical entity: amino-propan-2-one-3-phosphate
stoichiometric coefficient: 1.0

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot Q9RUB5 96
organism: Deinococcus radiodurans

Phosphoserine aminotransferase
type: ProteinReference
xref: uniprot Q7RWH9 28
organism: Neurospora crassa

PARTICIPANT STOICHIOMETRY r4 127
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Phosphoserine aminotransferase
type: ProteinReference
xref: PTHR43247:SF1
xref: uniprot Q99K85 42
organism: Mus musculus

uniprot Q8F930 36
type: UnificationXref
id: Q8F930
db: uniprot

Pyridoxine-5'-phosphate oxidase
type: ProteinReference
xref: PTHR10851:SF0
xref: uniprot Q9NVS9 70
organism: Homo sapiens

Phosphoserine aminotransferase
type: ProteinReference
xref: uniprot Q8F930 36
organism: Leptospira interrogans

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 11

1-deoxy-D-xylulose-5-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q96255 40
type: UnificationXref
id: Q96255
db: uniprot

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot P54523 83
organism: Bacillus subtilis

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 21

ncbitaxon 9544 13
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot Q9RX20 71
type: UnificationXref
id: Q9RX20
db: uniprot

PARTICIPANT STOICHIOMETRY r4 125
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

uniprot F7H2J8 12
type: UnificationXref
id: F7H2J8
db: uniprot

PARTICIPANT STOICHIOMETRY r4 124
type: Stoichiometry
physical entity: phospho-hydroxy-threonine
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__1_deoxy_D_xylulose_5_phosphate-_amino_propan_2_one_3_phosphate-RIGHT__pyridoxine_5_phosphate-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 121
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 122
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 123
left: 1-deoxy-D-xylulose-5-phosphate
left: amino-propan-2-one-3-phosphate
interaction type: STATE_TRANSITION
right: pyridoxine-5-phosphate

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot P9WNS3 86
organism: Mycobacterium tuberculosis

uniprot Q9RUB5 96
type: UnificationXref
id: Q9RUB5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__erythronate_4_phosphate-_NAD-RIGHT__NADH-_3_hydroxy_4_phospho_hydroxy_ketobutryate-_r2
controller: Erythronate-4-phosphate dehydrogenase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__glyceraldehyde_3_phosphate_pyruvate-_Pyruvate-RIGHT__1_deoxy_D_xylulose_5_phosphate-_CO2-_r7
controller: 1-Deoxyxylulose-5-phosphate synthase

3-hydroxy-4-phospho-hydroxy-ketobutryate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

pyridoxine-5-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ketoglutarate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Pyridoxine-5-phosphate oxidase
type: ProteinReference
xref: P03061
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Pyridoxine-5-phosphate oxidase Synonym: Synonym not specified Accession: P03061
comment: ENTITY_REFERENCE_ID_DESC=Pyridoxal-5-phosphate biosynthesis.PROTEIN.GENERIC.Pyridoxine-5-phosphate_br_oxidase
member entity reference: Probable pyridoxamine 5'-phosphate oxidase
member entity reference: Pyridoxine 5'-phosphate oxidase
member entity reference: Pyridoxine-5'-phosphate oxidase
member entity reference: Pyridoxine/pyridoxamine 5'-phosphate oxidase
member entity reference: PNPO isoform 1
member entity reference: Pyridoxamine 5'-phosphate oxidase
member entity reference: Pyridoxine/pyridoxamine 5'-phosphate oxidase 1, chloroplastic
member entity reference: AGAP002227-PA

uniprot A0A0P0WSV0 74
type: UnificationXref
id: A0A0P0WSV0
db: uniprot

Erythronate-4-phosphate dehydrogenase
type: Protein
entity reference: Erythronate-4-phosphate dehydrogenase
comment: SPECIES_TYPE=PROTEIN

1-deoxy-D-xylulose-5-phosphate synthase
type: ProteinReference
xref: uniprot O67036 77
organism: Aquifex aeolicus

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 75

PARTICIPANT STOICHIOMETRY r1 112
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 111
type: Stoichiometry
physical entity: erythronate-4-phosphate
stoichiometric coefficient: 1.0

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 52

PARTICIPANT STOICHIOMETRY r1 110
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

uniprot P77488 85
type: UnificationXref
id: P77488
db: uniprot

Erythronate-4-phosphate dehydrogenase
type: ProteinReference
xref: P03059
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Pyridoxal-5-phosphate biosynthesis.PROTEIN.GENERIC.Erythronate-4-phosphate_br_dehydrogenase
comment: ENTITY_REFERENCE_NOTES= Long Name: Erythronate-4-phosphate dehydrogenase Synonym: Synonym not specified Accession: P03059
member entity reference: Erythronate-4-phosphate dehydrogenase

uniprot Q9F2Y1 44
type: UnificationXref
id: Q9F2Y1
db: uniprot

uniprot P9WIJ1 62
type: UnificationXref
id: P9WIJ1
db: uniprot