Beta-ureidopropionase
type: ProteinReference
xref: uniprot Q8VC97 97
xref: PTHR43674:SF2
organism: Mus musculus

NADH + H+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uncharacterized protein
type: ProteinReference
evidence: Evidence 38
xref: PTHR11647:SF56
xref: uniprot A0A1D5QW32 37
organism: Macaca mulatta

Cytidine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P32320 121
type: UnificationXref
id: P32320
db: uniprot

uniprot Q61503 128
type: UnificationXref
id: Q61503
db: uniprot

uniprot O02675 54
type: UnificationXref
id: O02675
db: uniprot

uniprot F7EZH4 8
type: UnificationXref
id: F7EZH4
db: uniprot

PARTICIPANT STOICHIOMETRY r88 174
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r88 173
type: Stoichiometry
physical entity: Uridine
stoichiometric coefficient: 1.0

uniprot Q9L1J1 35
type: UnificationXref
id: Q9L1J1
db: uniprot

Methylmalonic acid semialdehyde dehydrogenase
type: ProteinReference
xref: PTHR43866:SF4
xref: uniprot Q9L1J1 35
organism: Streptomyces coelicolor

Ribose-1-Phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

4-aminobutyrate aminotransferase
type: ProteinReference
xref: PTHR43206:SF1
xref: uniprot H2QAJ4 107
organism: Pan troglodytes

uniprot E2R776 105
type: UnificationXref
id: E2R776
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 34

PARTICIPANT STOICHIOMETRY r95 152
type: Stoichiometry
physical entity: Beta-Ureidoisobutyrate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r95 151
type: Stoichiometry
physical entity: Dihydrothymine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r95 150
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 112

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 32

uniprot Q14117 58
type: UnificationXref
id: Q14117
db: uniprot

Pyrimidine-nucleoside phosphorylase
type: ProteinReference
xref: PTHR10515:SF0
xref: uniprot Q9RX72 85
organism: Deinococcus radiodurans

Dihydropyrimidine dehydrogenase [NADP(+)]
type: ProteinReference
xref: uniprot Q12882 103
xref: PTHR43073:SF2
organism: Homo sapiens

Dihydropyrimidinase-related protein 3
type: ProteinReference
xref: uniprot Q62952 63
xref: PTHR11647:SF57
organism: Rattus norvegicus

uniprot Q21217 118
type: UnificationXref
id: Q21217
db: uniprot

STATE_TRANSITION_LEFT__Beta_Ureidopropionate-_H2O-RIGHT__NH4__PLUS___PLUS__CO2-_Beta_Alanine-_r101
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r101 131
participant stoichiometry: PARTICIPANT STOICHIOMETRY r101 133
participant stoichiometry: PARTICIPANT STOICHIOMETRY r101 132
participant stoichiometry: PARTICIPANT STOICHIOMETRY r101 134
left: H2O
left: Beta-Ureidopropionate
interaction type: STATE_TRANSITION
right: NH4 + + CO2
right: Beta-Alanine

Aldehyde dehydrogenase 6 family member A1
type: ProteinReference
xref: PTHR43866:SF3
xref: uniprot J9P2I9 10
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r101 132
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r101 131
type: Stoichiometry
physical entity: Beta-Ureidopropionate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r101 134
type: Stoichiometry
physical entity: Beta-Alanine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r101 133
type: Stoichiometry
physical entity: NH4 + + CO2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r88 175
type: Stoichiometry
physical entity: Ribose-1-Phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r88 176
type: Stoichiometry
physical entity: Uracil
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR11647:SF50
xref: uniprot E1BFN6 40
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
evidence: Evidence 38
xref: uniprot F7DMI7 48
xref: PTHR11647:SF56
organism: Monodelphis domestica

uniprot P42412 18
type: UnificationXref
id: P42412
db: uniprot

Dihydropyrimidinase
type: ProteinReference
xref: P03125
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Pyrimidine Metabolism.PROTEIN.GENERIC.Dihydropyrimidinase
comment: ENTITY_REFERENCE_NOTES= Long Name: Dihydropyrimidinase Synonym: Synonym not specified Accession: P03125
member entity reference: Dihydropyrimidinase
member entity reference: DPYSL5 protein
member entity reference: Dihydropyrimidinase-related protein 2
member entity reference: Dihydropyrimidinase-related protein 3
member entity reference: Dihydropyrimidinase like 5
member entity reference: Dihydropyrimidinase-related protein 5
member entity reference: Dihydropyrimidinase-like 3
member entity reference: DPYS isoform 2
member entity reference: D-hydantoinase/dihydropyrimidinase
member entity reference: Os01g0807900 protein
member entity reference: Uncharacterized protein
member entity reference: Dihydropyrimidinase like 3
member entity reference: DPYSL2 isoform 2

uniprot Q9EQF5 72
type: UnificationXref
id: Q9EQF5
db: uniprot

PTHR43073:SF2
type: RelationshipXref
id: PTHR43073:SF2
db: PANTHER Family
relationship type: By Homology

ncbitaxon 188937 83
type: UnificationXref
id: 188937
db: ncbitaxon

Malonate-semialdehyde dehydrogenase
type: ProteinReference
xref: PTHR43866:SF4
xref: uniprot P42412 18
organism: Bacillus subtilis

uniprot F6X9A2 91
type: UnificationXref
id: F6X9A2
db: uniprot

5'-Nucleotidase
type: ProteinReference
xref: P03131
comment: ENTITY_REFERENCE_NOTES= Long Name: 5'-Nucleotidase Synonym: Synonym not specified Accession: P03131
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Pyrimidine Metabolism.PROTEIN.GENERIC.5_super_'_endsuper_-Nucleotidase
member entity reference: 5'-nucleotidase
member entity reference: 5'-nucleotidase ecto
member entity reference: Uncharacterized protein

eco ECO:0000304 30
type: UnificationXref
id: ECO:0000304
db: eco

STATE_TRANSITION_LEFT__Methylmelonate_semialdehyde-_CoA_SH__PLUS__NAD_PLUS_-RIGHT__Methylmelonyl_CoA-_NADH__PLUS__H_PLUS_-_r98
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r98 141
participant stoichiometry: PARTICIPANT STOICHIOMETRY r98 140
participant stoichiometry: PARTICIPANT STOICHIOMETRY r98 139
participant stoichiometry: PARTICIPANT STOICHIOMETRY r98 138
left: Methylmelonate semialdehyde
left: CoA-SH + NAD+
interaction type: STATE_TRANSITION
right: Methylmelonyl-CoA
right: NADH + H+

uniprot K7AKS9 12
type: UnificationXref
id: K7AKS9
db: uniprot

ncbitaxon 10116 24
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot F1Q3Y2 43
type: UnificationXref
id: F1Q3Y2
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 13

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 66

Dihydropyrimidinase
type: ProteinReference
xref: uniprot Q9FMP3 74
xref: PTHR11647:SF1
organism: Arabidopsis thaliana

Dihydropyrimidinase
type: ProteinReference
xref: PTHR11647:SF50
xref: uniprot Q63150 64
organism: Rattus norvegicus

Probable 4-aminobutyrate aminotransferase, mitochondrial
type: ProteinReference
xref: PTHR43206:SF1
xref: uniprot Q21217 118
organism: Caenorhabditis elegans

Beta-Aminoisobutyrate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q02253 23
type: UnificationXref
id: Q02253
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E2B9 6
xref: PTHR43866:SF3
organism: Macaca mulatta

ALDH6A1 isoform 1
type: ProteinReference
xref: uniprot K7AKS9 12
xref: PTHR43866:SF3
organism: Pan troglodytes

uniprot Q90635 67
type: UnificationXref
id: Q90635
db: uniprot

PTHR11647:SF1
type: RelationshipXref
id: PTHR11647:SF1
db: PANTHER Family
relationship type: By Homology

Dihydropyrimidinase-related protein 5
type: ProteinReference
xref: PTHR11647:SF58
xref: uniprot F6XU97 44
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r91 171
type: Stoichiometry
physical entity: NH4 +
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r91 172
type: Stoichiometry
physical entity: Uridine
stoichiometric coefficient: 1.0

uniprot F7CVF2 46
type: UnificationXref
id: F7CVF2
db: uniprot

ncbitaxon 9913 3
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot J9P2I9 10
type: UnificationXref
id: J9P2I9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADH__PLUS__H_PLUS_-_Thymine-RIGHT__NAD_PLUS_-_Dihydrothymine-_r94
controller: Dihydrouracil Dehydrogenase

PARTICIPANT STOICHIOMETRY r91 170
type: Stoichiometry
physical entity: Cytidine
stoichiometric coefficient: 1.0

uniprot A8E641 39
type: UnificationXref
id: A8E641
db: uniprot

uniprot H2QTC9 125
type: UnificationXref
id: H2QTC9
db: uniprot

uniprot Q9FMP3 74
type: UnificationXref
id: Q9FMP3
db: uniprot

Aldehyde dehydrogenase 6 family member A1
type: ProteinReference
xref: PTHR43866:SF3
xref: uniprot F7EZH4 8
organism: Monodelphis domestica

ncbitaxon 559292 112
type: UnificationXref
id: 559292
db: ncbitaxon

DPYSL2 isoform 2
type: ProteinReference
evidence: Evidence 38
xref: PTHR11647:SF56
xref: uniprot K6ZQM1 52
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r94 154
type: Stoichiometry
physical entity: Thymine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r94 155
type: Stoichiometry
physical entity: NAD+
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Beta_Ureidoisobutyrate-_H2O-RIGHT__NH4__PLUS___PLUS__CO2-_Beta_Aminoisobutyrate-_r96
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 147
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 146
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 149
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 148
left: Beta-Ureidoisobutyrate
left: H2O
interaction type: STATE_TRANSITION
right: Beta-Aminoisobutyrate
right: NH4 + + CO2

PARTICIPANT STOICHIOMETRY r94 156
type: Stoichiometry
physical entity: Dihydrothymine
stoichiometric coefficient: 1.0

uniprot P80404 117
type: UnificationXref
id: P80404
db: uniprot

PARTICIPANT STOICHIOMETRY r94 153
type: Stoichiometry
physical entity: NADH + H+
stoichiometric coefficient: 1.0

uniprot Q22922 122
type: UnificationXref
id: Q22922
db: uniprot

uniprot O53816 14
type: UnificationXref
id: O53816
db: uniprot

5'-nucleotidase
type: ProteinReference
xref: uniprot P21588 126
xref: PTHR11575:SF25
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r91 169
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

5'-nucleotidase
type: ProteinReference
xref: uniprot P21589 127
xref: PTHR11575:SF25
organism: Homo sapiens

Dihydropyrimidinase-like 3
type: ProteinReference
xref: uniprot K7B2Z5 53
xref: PTHR11647:SF57
organism: Pan troglodytes

Beta-ureidopropionase
type: ProteinReference
xref: uniprot Q8H183 96
xref: PTHR43674:SF2
organism: Arabidopsis thaliana

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q656 123
xref: PTHR11575:SF25
organism: Macaca mulatta

Aminotransferase
type: Protein
entity reference: Aminotransferase
comment: SPECIES_TYPE=PROTEIN

Dihydropyrimidinase-related protein 3
type: ProteinReference
xref: uniprot Q62188 62
xref: PTHR11647:SF57
organism: Mus musculus

uniprot P21588 126
type: UnificationXref
id: P21588
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Uridine-_Pi-RIGHT__Ribose_1_Phosphate-_Uracil-_r88
controller: Nucleoside Phosphorylase

uniprot A8WTW8 89
type: UnificationXref
id: A8WTW8
db: uniprot

2-Deoxyribose-1-Phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__Dihydrouracil-_H2O-RIGHT__Beta_Ureidopropionate-_r100
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r100 135
participant stoichiometry: PARTICIPANT STOICHIOMETRY r100 137
participant stoichiometry: PARTICIPANT STOICHIOMETRY r100 136
left: H2O
left: Dihydrouracil
interaction type: STATE_TRANSITION
right: Beta-Ureidopropionate

Dihydropyrimidinase-related protein 2
type: ProteinReference
evidence: Evidence 55
xref: uniprot O02675 54
xref: PTHR11647:SF56
organism: Bos taurus

PTHR43674:SF2
type: RelationshipXref
id: PTHR43674:SF2
db: PANTHER Family
relationship type: By Homology

uniprot E2RSE5 41
type: UnificationXref
id: E2RSE5
db: uniprot

ncbitaxon 6238 90
type: UnificationXref
id: 6238
db: ncbitaxon

Cytidine Deaminase
type: Protein
entity reference: Cytidine Deaminase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 243274 88
type: UnificationXref
id: 243274
db: ncbitaxon

Beta-Ureidopropionase
type: Protein
entity reference: Beta-Ureidopropionase
comment: SPECIES_TYPE=PROTEIN

uniprot Q8VC97 97
type: UnificationXref
id: Q8VC97
db: uniprot

uniprot Q8TL01 82
type: UnificationXref
id: Q8TL01
db: uniprot

Pyrimidine Metabolism
type: Pathway
pathway component: STATE_TRANSITION_LEFT__H2O-_Cytidine-RIGHT__NH4__PLUS_-_Uridine-_r91
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__Methylmelonyl_CoA-RIGHT__Succinyl_CoA-_r102
pathway component: STATE_TRANSITION_LEFT__CMP-_H2O-RIGHT__Pi-_Cytidine-_r90
pathway component: STATE_TRANSITION_LEFT__UMP-_H2O-RIGHT__Uridine-_Pi-_r87
pathway component: STATE_TRANSITION_LEFT__NADH__PLUS__H_PLUS_-_Uracil-RIGHT__NAD_PLUS_-_Dihydrouracil-_r89
pathway component: STATE_TRANSITION_LEFT__Dihydrouracil-_H2O-RIGHT__Beta_Ureidopropionate-_r100
pathway component: STATE_TRANSITION_LEFT__Beta_Ureidopropionate-_H2O-RIGHT__NH4__PLUS___PLUS__CO2-_Beta_Alanine-_r101
pathway component: STATE_TRANSITION_LEFT__2_Oxoglutarate-_Beta_Aminoisobutyrate-RIGHT__Glutamate-_Methylmelonate_semialdehyde-_r97
pathway component: STATE_TRANSITION_LEFT__H2O-_Dihydrothymine-RIGHT__Beta_Ureidoisobutyrate-_r95
pathway component: STATE_TRANSITION_LEFT__Uridine-_Pi-RIGHT__Ribose_1_Phosphate-_Uracil-_r88
pathway component: STATE_TRANSITION_LEFT__Thymidine-_Pi-RIGHT__2_Deoxyribose_1_Phosphate-_Thymine-_r93
pathway component: STATE_TRANSITION_LEFT__NADH__PLUS__H_PLUS_-_Thymine-RIGHT__NAD_PLUS_-_Dihydrothymine-_r94
pathway component: STATE_TRANSITION_LEFT__dTMP-_H2O-RIGHT__Thymidine-_Pi-_r92
pathway component: STATE_TRANSITION_LEFT__Beta_Ureidoisobutyrate-_H2O-RIGHT__NH4__PLUS___PLUS__CO2-_Beta_Aminoisobutyrate-_r96
pathway component: STATE_TRANSITION_LEFT__Methylmelonate_semialdehyde-_CoA_SH__PLUS__NAD_PLUS_-RIGHT__Methylmelonyl_CoA-_NADH__PLUS__H_PLUS_-_r98
xref: PANTHER Pathway P02771 1
comment: MODEL_NOTES= The pattern of breakdown is very different for the two types of nucletide bases, purines and pyrimidines. In the case of pyrimidines the ring is reduced and then opened, and with the exception of beta-alanine the nitrogen is removed by deamination and transamination as ammonia, which must ultimately be converted into urea. However, in the case of purines only the amino nitrogen outside the ring is removed as ammonia. The purine ring itself is oxidized to uric acid by xanthine oxidase and excreted. In humans and primates, the conversion of urate to allantoin occurs non-enzymatically by interaction with oxygen free radicals. free text=Biochemiscal Pathways - An Atlas of Biochemistry and Molecular Biology Edited by Gerhard Michal free text=Color Atlas of Biochemistry by Jan Koolman and Klaus-Heinrich Rohm free text=Human Metabolism by Ramsey Bronk

Dihydropyrimidine dehydrogenase [NADP(+)]
type: ProteinReference
xref: PTHR43073:SF2
xref: uniprot Q8CHR6 104
organism: Mus musculus

DPYSL5 protein
type: ProteinReference
xref: uniprot A8E641 39
xref: PTHR11647:SF58
organism: Bos taurus

Dihydropyrimidinase-related protein 5
type: ProteinReference
xref: PTHR11647:SF58
xref: uniprot Q9BPU6 71
organism: Homo sapiens

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 19

uniprot H2PY87 120
type: UnificationXref
id: H2PY87
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 3

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 7

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 47

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Dihydrouracil-_H2O-RIGHT__Beta_Ureidopropionate-_r100
controller: Dihydropyrimidinase

Dihydropyrimidinase like 5
type: ProteinReference
xref: PTHR11647:SF58
xref: uniprot F6ZT50 45
organism: Monodelphis domestica

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 70

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Beta_Ureidopropionate-_H2O-RIGHT__NH4__PLUS___PLUS__CO2-_Beta_Alanine-_r101
controller: Beta-Ureidopropionase

AMP phosphorylase
type: ProteinReference
xref: PTHR10515:SF0
xref: uniprot Q58081 80
organism: Methanocaldococcus jannaschii

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 83

Dihydrouracil
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Dihydropyrimidinase-related protein 2
type: ProteinReference
evidence: Evidence 55
xref: PTHR11647:SF56
xref: uniprot P47942 57
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__UMP-_H2O-RIGHT__Uridine-_Pi-_r87
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 182
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 183
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 184
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 181
left: UMP
left: H2O
interaction type: STATE_TRANSITION
right: Uridine
right: Pi

2-Oxoglutarate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Dihydropyrimidinase like 3
type: ProteinReference
xref: uniprot F1Q3Y2 43
xref: PTHR11647:SF57
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_Cytidine-RIGHT__NH4__PLUS_-_Uridine-_r91
controller: Cytidine Deaminase

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 11

uniprot O08553 56
type: UnificationXref
id: O08553
db: uniprot

UreidoPropionase Beta
type: ProteinReference
xref: uniprot Q19437 94
xref: PTHR43674:SF2
organism: Caenorhabditis elegans

Beta-Ureidoisobutyrate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
type: ProteinReference
xref: PTHR43866:SF3
xref: uniprot Q7KW39 31
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r96 148
type: Stoichiometry
physical entity: NH4 + + CO2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r96 147
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

ncbitaxon 10090 34
type: UnificationXref
id: 10090
db: ncbitaxon

PTHR43206:SF1
type: RelationshipXref
id: PTHR43206:SF1
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r96 146
type: Stoichiometry
physical entity: Beta-Ureidoisobutyrate
stoichiometric coefficient: 1.0

uniprot H2QLD8 92
type: UnificationXref
id: H2QLD8
db: uniprot

PARTICIPANT STOICHIOMETRY r96 149
type: Stoichiometry
physical entity: Beta-Aminoisobutyrate
stoichiometric coefficient: 1.0

Uridine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 68

uniprot P14010 108
type: UnificationXref
id: P14010
db: uniprot

uniprot K6ZQM1 52
type: UnificationXref
id: K6ZQM1
db: uniprot

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 36

Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
type: ProteinReference
xref: PTHR43866:SF3
xref: uniprot Q02253 23
organism: Rattus norvegicus

Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
type: ProteinReference
xref: PTHR43866:SF3
xref: uniprot Q02252 20
organism: Homo sapiens

uniprot Q7KW39 31
type: UnificationXref
id: Q7KW39
db: uniprot

Cytidine deaminase
type: ProteinReference
xref: uniprot P32320 121
xref: PTHR11644:SF2
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r90 180
type: Stoichiometry
physical entity: Cytidine
stoichiometric coefficient: 1.0

uniprot Q12882 103
type: UnificationXref
id: Q12882
db: uniprot

Thymidine phosphorylase
type: ProteinReference
xref: PTHR10515:SF0
xref: uniprot P07650 77
organism: Escherichia coli

eco ECO:0000501 70
type: UnificationXref
id: ECO:0000501
db: eco

STATE_TRANSITION
type: RelationshipTypeVocabulary

Dihydropyrimidinase like 5
type: ProteinReference
xref: PTHR11647:SF58
xref: uniprot F7CVF2 46
organism: Ornithorhynchus anatinus

PTHR11644:SF2
type: RelationshipXref
id: PTHR11644:SF2
db: PANTHER Family
relationship type: By Homology

Dihydrothymine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r102 130
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

uniprot H2QWJ9 50
type: UnificationXref
id: H2QWJ9
db: uniprot

uniprot Q0WM29 26
type: UnificationXref
id: Q0WM29
db: uniprot

Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
type: ProteinReference
xref: PTHR43866:SF3
xref: uniprot Q9EQ20 33
organism: Mus musculus

STATE_TRANSITION_LEFT__dTMP-_H2O-RIGHT__Thymidine-_Pi-_r92
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r92 164
participant stoichiometry: PARTICIPANT STOICHIOMETRY r92 161
participant stoichiometry: PARTICIPANT STOICHIOMETRY r92 163
participant stoichiometry: PARTICIPANT STOICHIOMETRY r92 162
left: H2O
left: dTMP
interaction type: STATE_TRANSITION
right: Thymidine
right: Pi

NH4 + + CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Beta-Ureidopropionase
type: ProteinReference
xref: P03127
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Pyrimidine Metabolism.PROTEIN.GENERIC._Beta_-Ureidopropionase
comment: ENTITY_REFERENCE_NOTES= Long Name: Beta-Ureidopropionase Synonym: Synonym not specified Accession: P03127
member entity reference: Beta-ureidopropionase
member entity reference: Protein CBR-UPB-1
member entity reference: Uncharacterized protein
member entity reference: UreidoPropionase Beta
member entity reference: Beta-ureidopropionase 1

PARTICIPANT STOICHIOMETRY r90 177
type: Stoichiometry
physical entity: CMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r90 178
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r90 179
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r102 129
type: Stoichiometry
physical entity: Methylmelonyl-CoA
stoichiometric coefficient: 1.0

Protein CBR-UPB-1
type: ProteinReference
xref: PTHR43674:SF2
xref: uniprot A8WTW8 89
organism: Caenorhabditis briggsae

P03126
type: UnificationXref
id: P03126
db: PANTHER Pathway Component

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 90

P03127
type: UnificationXref
id: P03127
db: PANTHER Pathway Component

P03124
type: UnificationXref
id: P03124
db: PANTHER Pathway Component

P03125
type: UnificationXref
id: P03125
db: PANTHER Pathway Component

uniprot F1PK01 42
type: UnificationXref
id: F1PK01
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 95

KNOWN_TRANSITION_OMITTED_LEFT__Methylmelonyl_CoA-RIGHT__Succinyl_CoA-_r102
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY r102 129
participant stoichiometry: PARTICIPANT STOICHIOMETRY r102 130
left: Methylmelonyl-CoA
interaction type: KNOWN_TRANSITION_OMITTED
right: Succinyl-CoA

4-aminobutyrate aminotransferase
type: ProteinReference
xref: PTHR43206:SF1
xref: uniprot P49604 113
organism: Ustilago maydis

uniprot H2QAJ4 107
type: UnificationXref
id: H2QAJ4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Beta_Ureidoisobutyrate-_H2O-RIGHT__NH4__PLUS___PLUS__CO2-_Beta_Aminoisobutyrate-_r96
controller: Beta-Ureidopropionase

Aminotransferase
type: ProteinReference
xref: P03129
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Aminotransferase Synonym: Synonym not specified Accession: P03129
comment: ENTITY_REFERENCE_ID_DESC=Pyrimidine Metabolism.PROTEIN.GENERIC.Aminotransferase
member entity reference: 4-aminobutyrate aminotransferase
member entity reference: 4-aminobutyrate aminotransferase, mitochondrial
member entity reference: Probable 4-aminobutyrate aminotransferase, mitochondrial

dTMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

P03129
type: UnificationXref
id: P03129
db: PANTHER Pathway Component

uniprot Q94J90 69
type: UnificationXref
id: Q94J90
db: uniprot

P03128
type: UnificationXref
id: P03128
db: PANTHER Pathway Component

AMP phosphorylase
type: ProteinReference
xref: PTHR10515:SF0
xref: uniprot Q8TL01 82
organism: Methanosarcina acetivorans

Thymine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 29

P03131
type: UnificationXref
id: P03131
db: PANTHER Pathway Component

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 17

Dihydropyrimidinase-related protein 2
type: ProteinReference
evidence: Evidence 55
xref: uniprot O08553 56
xref: PTHR11647:SF56
organism: Mus musculus

ncbitaxon 39947 29
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot Q9BPU6 71
type: UnificationXref
id: Q9BPU6
db: uniprot

uniprot P61922 116
type: UnificationXref
id: P61922
db: uniprot

P03130
type: UnificationXref
id: P03130
db: PANTHER Pathway Component

uniprot F7FXK5 49
type: UnificationXref
id: F7FXK5
db: uniprot

uniprot H2PZG2 101
type: UnificationXref
id: H2PZG2
db: uniprot

Thymidine phosphorylase
type: ProteinReference
xref: PTHR10515:SF0
xref: uniprot Q9AK36 84
organism: Streptomyces coelicolor

ncbitaxon 13616 9
type: UnificationXref
id: 13616
db: ncbitaxon

ncbitaxon 237631 114
type: UnificationXref
id: 237631
db: ncbitaxon

STATE_TRANSITION_LEFT__H2O-_Cytidine-RIGHT__NH4__PLUS_-_Uridine-_r91
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r91 172
participant stoichiometry: PARTICIPANT STOICHIOMETRY r91 170
participant stoichiometry: PARTICIPANT STOICHIOMETRY r91 171
participant stoichiometry: PARTICIPANT STOICHIOMETRY r91 169
left: H2O
left: Cytidine
interaction type: STATE_TRANSITION
right: Uridine
right: NH4 +

uniprot A0A3Q1LN22 2
type: UnificationXref
id: A0A3Q1LN22
db: uniprot

Thymidine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

4-aminobutyrate aminotransferase
type: ProteinReference
xref: PTHR43206:SF1
xref: uniprot E2R776 105
organism: Canis lupus familiaris

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 124

Dihydropyrimidinase
type: ProteinReference
xref: PTHR11647:SF50
xref: uniprot Q14117 58
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r89 168
type: Stoichiometry
physical entity: Dihydrouracil
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r89 167
type: Stoichiometry
physical entity: NAD+
stoichiometric coefficient: 1.0

ncbitaxon 83332 15
type: UnificationXref
id: 83332
db: ncbitaxon

uniprot Q16555 61
type: UnificationXref
id: Q16555
db: uniprot

PARTICIPANT STOICHIOMETRY r89 166
type: Stoichiometry
physical entity: Uracil
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r89 165
type: Stoichiometry
physical entity: NADH + H+
stoichiometric coefficient: 1.0

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 88

Cytidine Deaminase
type: ProteinReference
xref: P03130
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Pyrimidine Metabolism.PROTEIN.GENERIC.Cytidine Deaminase
comment: ENTITY_REFERENCE_NOTES= Long Name: Cytidine Deaminase Synonym: Synonym not specified Accession: P03130
member entity reference: Cytidine deaminase

uniprot Q6Z4E4 28
type: UnificationXref
id: Q6Z4E4
db: uniprot

By Homology
type: RelationshipTypeVocabulary

uniprot F6ZT50 45
type: UnificationXref
id: F6ZT50
db: uniprot

Probable methylmalonate-semialdehyde dehydrogenase MmsA (Methylmalonic acid semialdehyde dehydrogenase) (MMSDH)
type: ProteinReference
xref: PTHR43866:SF4
xref: uniprot O53816 14
organism: Mycobacterium tuberculosis

uniprot P50554 115
type: UnificationXref
id: P50554
db: uniprot

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 22

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 4

PARTICIPANT STOICHIOMETRY r87 183
type: Stoichiometry
physical entity: Uridine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r87 184
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r87 181
type: Stoichiometry
physical entity: UMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r93 158
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r87 182
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r93 157
type: Stoichiometry
physical entity: Thymidine
stoichiometric coefficient: 1.0

IMP
type: EvidenceCodeVocabulary

Dihydropyrimidinase
type: ProteinReference
xref: PTHR11647:SF50
xref: uniprot E2RSE5 41
organism: Canis lupus familiaris

STATE_TRANSITION_LEFT__Uridine-_Pi-RIGHT__Ribose_1_Phosphate-_Uracil-_r88
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r88 173
participant stoichiometry: PARTICIPANT STOICHIOMETRY r88 176
participant stoichiometry: PARTICIPANT STOICHIOMETRY r88 174
participant stoichiometry: PARTICIPANT STOICHIOMETRY r88 175
left: Uridine
left: Pi
interaction type: STATE_TRANSITION
right: Uracil
right: Ribose-1-Phosphate

uniprot Q9JHU0 76
type: UnificationXref
id: Q9JHU0
db: uniprot

Nucleoside Phosphorylase
type: ProteinReference
xref: P03126
comment: ENTITY_REFERENCE_NOTES= Long Name: Nucleoside Phosphorylase Synonym: Synonym not specified Accession: P03126
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Pyrimidine Metabolism.PROTEIN.GENERIC.Nucleoside_br_Phosphorylase
member entity reference: AMP phosphorylase
member entity reference: Thymidine phosphorylase
member entity reference: Pyrimidine-nucleoside phosphorylase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__UMP-_H2O-RIGHT__Uridine-_Pi-_r87
controller: 5'-Nucleotidase

Dihydropyrimidine dehydrogenase [NADP(+)]
type: ProteinReference
xref: PTHR43073:SF2
xref: uniprot F1N549 99
organism: Bos taurus

Methylmelonate semialdehyde
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Methylmalonate Semialdehyde Dehydrogenase
type: Protein
entity reference: Methylmalonate Semialdehyde Dehydrogenase
comment: SPECIES_TYPE=PROTEIN

NH4 +
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CMP-_H2O-RIGHT__Pi-_Cytidine-_r90
controller: 5'-Nucleotidase

PARTICIPANT STOICHIOMETRY r93 160
type: Stoichiometry
physical entity: Thymine
stoichiometric coefficient: 1.0

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 9

4-aminobutyrate aminotransferase, mitochondrial
type: ProteinReference
xref: PTHR43206:SF1
xref: uniprot P80404 117
organism: Homo sapiens

uniprot A0A1D5Q656 123
type: UnificationXref
id: A0A1D5Q656
db: uniprot

PARTICIPANT STOICHIOMETRY r93 159
type: Stoichiometry
physical entity: 2-Deoxyribose-1-Phosphate
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CMP-_H2O-RIGHT__Pi-_Cytidine-_r90
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 180
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 179
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 177
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 178
left: H2O
left: CMP
interaction type: STATE_TRANSITION
right: Cytidine
right: Pi

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__2_Oxoglutarate-_Beta_Aminoisobutyrate-RIGHT__Glutamate-_Methylmelonate_semialdehyde-_r97
controller: Aminotransferase

uniprot F7DMI7 48
type: UnificationXref
id: F7DMI7
db: uniprot

Pyrimidine-nucleoside phosphorylase
type: ProteinReference
xref: PTHR10515:SF0
xref: uniprot P39142 79
organism: Bacillus subtilis

Cytidine deaminase
type: ProteinReference
xref: uniprot H2PY87 120
xref: PTHR11644:SF2
organism: Pan troglodytes

uniprot Q9EQF6 73
type: UnificationXref
id: Q9EQF6
db: uniprot

uniprot Q9S5X9 87
type: UnificationXref
id: Q9S5X9
db: uniprot

IEP
type: EvidenceCodeVocabulary
xref: eco ECO:0000270 110

Beta-Alanine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7GVE2 100
type: UnificationXref
id: F7GVE2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6X9A2 91
xref: PTHR43674:SF2
organism: Macaca mulatta

uniprot P49604 113
type: UnificationXref
id: P49604
db: uniprot

Dihydropyrimidine dehydrogenase [NADP(+)]
type: ProteinReference
xref: PTHR43073:SF2
xref: uniprot O89000 102
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__Thymidine-_Pi-RIGHT__2_Deoxyribose_1_Phosphate-_Thymine-_r93
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r93 158
participant stoichiometry: PARTICIPANT STOICHIOMETRY r93 160
participant stoichiometry: PARTICIPANT STOICHIOMETRY r93 157
participant stoichiometry: PARTICIPANT STOICHIOMETRY r93 159
left: Thymidine
left: Pi
interaction type: STATE_TRANSITION
right: Thymine
right: 2-Deoxyribose-1-Phosphate

Dihydropyrimidinase like 5
type: ProteinReference
xref: PTHR11647:SF58
xref: uniprot H2R8X1 51
organism: Pan troglodytes

ncbitaxon 243230 86
type: UnificationXref
id: 243230
db: ncbitaxon

Succinyl-CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 8364 66
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot Q9I676 75
type: UnificationXref
id: Q9I676
db: uniprot

5'-nucleotidase
type: ProteinReference
xref: uniprot Q61503 128
xref: PTHR11575:SF25
organism: Mus musculus

Methylmalonate-semialdehyde dehydrogenase [acylating]
type: ProteinReference
xref: PTHR43866:SF3
xref: uniprot P28810 16
organism: Pseudomonas aeruginosa

uniprot F6XU97 44
type: UnificationXref
id: F6XU97
db: uniprot

uniprot K7B2Z5 53
type: UnificationXref
id: K7B2Z5
db: uniprot

UMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADH__PLUS__H_PLUS_-_Uracil-RIGHT__NAD_PLUS_-_Dihydrouracil-_r89
controller: Dihydrouracil Dehydrogenase

eco ECO:0000303 25
type: UnificationXref
id: ECO:0000303
db: eco

ncbitaxon 9258 47
type: UnificationXref
id: 9258
db: ncbitaxon

Beta-ureidopropionase 1
type: ProteinReference
xref: uniprot H2QLD8 92
xref: PTHR43674:SF2
organism: Pan troglodytes

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 86

ncbitaxon 9598 13
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot P39142 79
type: UnificationXref
id: P39142
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 21

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 81

DPYS isoform 2
type: ProteinReference
xref: PTHR11647:SF50
xref: uniprot H2QWJ9 50
organism: Pan troglodytes

Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
type: ProteinReference
xref: PTHR43866:SF3
xref: uniprot Q0WM29 26
organism: Arabidopsis thaliana

Methylmalonate semi-aldehyde dehydrogenase
type: ProteinReference
xref: uniprot Q6Z4E4 28
xref: PTHR43866:SF3
organism: Oryza sativa

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__dTMP-_H2O-RIGHT__Thymidine-_Pi-_r92
controller: 5'-Nucleotidase

uniprot H2R8X1 51
type: UnificationXref
id: H2R8X1
db: uniprot

Pyrimidine-nucleoside phosphorylase
type: ProteinReference
xref: PTHR10515:SF0
xref: uniprot Q9S5X9 87
organism: Thermotoga maritima

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 27

D-hydantoinase/dihydropyrimidinase
type: ProteinReference
xref: PTHR11647:SF1
xref: uniprot Q9I676 75
organism: Pseudomonas aeruginosa

Beta-ureidopropionase
type: ProteinReference
xref: uniprot Q9UBR1 98
xref: PTHR43674:SF2
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FXK5 49
xref: PTHR11647:SF50
organism: Macaca mulatta

eco ECO:0000245 124
type: UnificationXref
id: ECO:0000245
db: eco

uniprot P07650 77
type: UnificationXref
id: P07650
db: uniprot

PARTICIPANT STOICHIOMETRY r97 142
type: Stoichiometry
physical entity: 2-Oxoglutarate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r97 143
type: Stoichiometry
physical entity: Beta-Aminoisobutyrate
stoichiometric coefficient: 1.0

ncbitaxon 208964 17
type: UnificationXref
id: 208964
db: ncbitaxon

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 15

Dihydropyrimidine dehydrogenase [NADP(+)]
type: ProteinReference
xref: PTHR43073:SF2
xref: uniprot F7GVE2 100
organism: Macaca mulatta

uniprot P47942 57
type: UnificationXref
id: P47942
db: uniprot

eco ECO:0000250 4
type: UnificationXref
id: ECO:0000250
db: eco

ncbitaxon 224308 19
type: UnificationXref
id: 224308
db: ncbitaxon

CMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

eco ECO:0000270 110
type: UnificationXref
id: ECO:0000270
db: eco

Evidence 38
type: Evidence
evidence code: ISS
comment: SPACC Q90635

Methylmalonate Semialdehyde Dehydrogenase
type: ProteinReference
xref: P03124
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Methylmalonate Semialdehyde Dehydrogenase Synonym: Synonym not specified Accession: P03124
comment: ENTITY_REFERENCE_ID_DESC=Pyrimidine Metabolism.PROTEIN.GENERIC.Methylmalonate_br_Semialdehyde_br_Dehydrogenase
member entity reference: Aldehyde dehydrogenase 6 family member A1
member entity reference: ALDH6A1 isoform 1
member entity reference: Methylmalonate semi-aldehyde dehydrogenase
member entity reference: Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
member entity reference: Uncharacterized protein
member entity reference: Methylmalonic acid semialdehyde dehydrogenase
member entity reference: Probable methylmalonate-semialdehyde dehydrogenase MmsA (Methylmalonic acid semialdehyde dehydrogenase) (MMSDH)
member entity reference: Methylmalonate-semialdehyde dehydrogenase [acylating]
member entity reference: Malonate-semialdehyde dehydrogenase
member entity reference: Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 78

uniprot Q9EQ20 33
type: UnificationXref
id: Q9EQ20
db: uniprot

4-aminobutyrate aminotransferase
type: ProteinReference
xref: PTHR43206:SF1
xref: uniprot P14010 108
organism: Emericella nidulans

ncbitaxon 9031 68
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot Q14195 60
type: UnificationXref
id: Q14195
db: uniprot

4-aminobutyrate aminotransferase, mitochondrial
type: ProteinReference
xref: PTHR43206:SF1
xref: uniprot P61922 116
organism: Mus musculus

uniprot Q02252 20
type: UnificationXref
id: Q02252
db: uniprot

Beta-Ureidopropionate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__NADH__PLUS__H_PLUS_-_Uracil-RIGHT__NAD_PLUS_-_Dihydrouracil-_r89
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r89 165
participant stoichiometry: PARTICIPANT STOICHIOMETRY r89 168
participant stoichiometry: PARTICIPANT STOICHIOMETRY r89 167
participant stoichiometry: PARTICIPANT STOICHIOMETRY r89 166
left: Uracil
left: NADH + H+
interaction type: STATE_TRANSITION
right: NAD+
right: Dihydrouracil

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 114

ncbitaxon 6239 95
type: UnificationXref
id: 6239
db: ncbitaxon

Glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P21589 127
type: UnificationXref
id: P21589
db: uniprot

NAD+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 227321 109
type: UnificationXref
id: 227321
db: ncbitaxon

ncbitaxon 9606 21
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot F1MFB7 106
type: UnificationXref
id: F1MFB7
db: uniprot

ncbitaxon 243232 81
type: UnificationXref
id: 243232
db: ncbitaxon

4-aminobutyrate aminotransferase, mitochondrial
type: ProteinReference
xref: PTHR43206:SF1
xref: uniprot P50554 115
organism: Rattus norvegicus

Dihydropyrimidinase-related protein 5
type: ProteinReference
xref: PTHR11647:SF58
xref: uniprot Q9EQF6 73
organism: Mus musculus

Dihydropyrimidinase
type: ProteinReference
xref: PTHR11647:SF50
xref: uniprot Q9EQF5 72
organism: Mus musculus

Aldehyde dehydrogenase 6 family member A1
type: ProteinReference
xref: PTHR43866:SF3
xref: uniprot A0A3Q1LN22 2
organism: Bos taurus

PANTHER Pathway P02771 1
type: UnificationXref
id: P02771
db: PANTHER Pathway

uniprot P28810 16
type: UnificationXref
id: P28810
db: uniprot

Dihydropyrimidinase-related protein 2
type: ProteinReference
xref: PTHR11647:SF56
xref: uniprot Q90635 67
organism: Gallus gallus

uniprot Q6GL72 65
type: UnificationXref
id: Q6GL72
db: uniprot

Evidence 55
type: Evidence
evidence code: TAS
comment: SPACC Q90635

NAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000303 25

PARTICIPANT STOICHIOMETRY r97 144
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r97 145
type: Stoichiometry
physical entity: Methylmelonate semialdehyde
stoichiometric coefficient: 1.0

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 30

Dihydropyrimidinase-related protein 3
type: ProteinReference
xref: uniprot Q14195 60
xref: PTHR11647:SF57
organism: Homo sapiens

PTHR11644:SF11
type: RelationshipXref
id: PTHR11644:SF11
db: PANTHER Family
relationship type: By Homology

uniprot P17649 111
type: UnificationXref
id: P17649
db: uniprot

uniprot Q9AK36 84
type: UnificationXref
id: Q9AK36
db: uniprot

uniprot O89000 102
type: UnificationXref
id: O89000
db: uniprot

CoA-SH + NAD+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9615 11
type: UnificationXref
id: 9615
db: ncbitaxon

STATE_TRANSITION_LEFT__2_Oxoglutarate-_Beta_Aminoisobutyrate-RIGHT__Glutamate-_Methylmelonate_semialdehyde-_r97
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r97 143
participant stoichiometry: PARTICIPANT STOICHIOMETRY r97 144
participant stoichiometry: PARTICIPANT STOICHIOMETRY r97 142
participant stoichiometry: PARTICIPANT STOICHIOMETRY r97 145
left: Beta-Aminoisobutyrate
left: 2-Oxoglutarate
interaction type: STATE_TRANSITION
right: Glutamate
right: Methylmelonate semialdehyde

5'-Nucleotidase
type: Protein
entity reference: 5'-Nucleotidase
comment: SPECIES_TYPE=PROTEIN

Beta-ureidopropionase 1
type: ProteinReference
xref: PTHR43674:SF2
xref: uniprot J9P8R1 93
organism: Canis lupus familiaris

Dihydropyrimidinase
type: Protein
entity reference: Dihydropyrimidinase
comment: SPECIES_TYPE=PROTEIN

Dihydropyrimidinase-related protein 3
type: ProteinReference
xref: uniprot Q6GL72 65
xref: PTHR11647:SF57
organism: Xenopus tropicalis

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 24

Os01g0807900 protein
type: ProteinReference
xref: PTHR11647:SF1
xref: uniprot Q94J90 69
organism: Oryza sativa

uniprot Q62952 63
type: UnificationXref
id: Q62952
db: uniprot

eco ECO:0000353 22
type: UnificationXref
id: ECO:0000353
db: eco

Dihydropyrimidinase like 5
type: ProteinReference
xref: uniprot F1PK01 42
xref: PTHR11647:SF58
organism: Canis lupus familiaris

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

uniprot Q58081 80
type: UnificationXref
id: Q58081
db: uniprot

PTHR10515:SF0
type: RelationshipXref
id: PTHR10515:SF0
db: PANTHER Family
relationship type: By Homology

uniprot F7E2B9 6
type: UnificationXref
id: F7E2B9
db: uniprot

uniprot Q62188 62
type: UnificationXref
id: Q62188
db: uniprot

Uracil
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Nucleoside Phosphorylase
type: Protein
entity reference: Nucleoside Phosphorylase
comment: SPECIES_TYPE=PROTEIN

uniprot Q8H183 96
type: UnificationXref
id: Q8H183
db: uniprot

Dihydrouracil Dehydrogenase
type: ProteinReference
xref: P03128
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Dihydrouracil Dehydrogenase Synonym: Synonym not specified Accession: P03128
comment: ENTITY_REFERENCE_ID_DESC=Pyrimidine Metabolism.PROTEIN.GENERIC.Dihydrouracil_br_Dehydrogenase
member entity reference: Dihydropyrimidine dehydrogenase [NADP(+)]

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_Dihydrothymine-RIGHT__Beta_Ureidoisobutyrate-_r95
controller: Dihydropyrimidinase

PARTICIPANT STOICHIOMETRY r100 135
type: Stoichiometry
physical entity: Dihydrouracil
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r100 136
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

uniprot Q19437 94
type: UnificationXref
id: Q19437
db: uniprot

PARTICIPANT STOICHIOMETRY r100 137
type: Stoichiometry
physical entity: Beta-Ureidopropionate
stoichiometric coefficient: 1.0

4-aminobutyrate aminotransferase
type: ProteinReference
xref: uniprot P17649 111
xref: PTHR43206:SF1
organism: Saccharomyces cerevisiae

Methylmelonyl-CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION
type: InteractionVocabulary

Dihydropyrimidinase-related protein 5
type: ProteinReference
xref: PTHR11647:SF58
xref: uniprot Q9JHU0 76
organism: Rattus norvegicus

uniprot Q9UBR1 98
type: UnificationXref
id: Q9UBR1
db: uniprot

PARTICIPANT STOICHIOMETRY r92 164
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r92 163
type: Stoichiometry
physical entity: Thymidine
stoichiometric coefficient: 1.0

PTHR11647:SF50
type: RelationshipXref
id: PTHR11647:SF50
db: PANTHER Family
relationship type: By Homology

Dihydrouracil Dehydrogenase
type: Protein
entity reference: Dihydrouracil Dehydrogenase
comment: SPECIES_TYPE=PROTEIN

PTHR11647:SF58
type: RelationshipXref
id: PTHR11647:SF58
db: PANTHER Family
relationship type: By Homology

PTHR11647:SF57
type: RelationshipXref
id: PTHR11647:SF57
db: PANTHER Family
relationship type: By Homology

PTHR11647:SF56
type: RelationshipXref
id: PTHR11647:SF56
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r92 162
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

uniprot A0A1D5QW32 37
type: UnificationXref
id: A0A1D5QW32
db: uniprot

PARTICIPANT STOICHIOMETRY r92 161
type: Stoichiometry
physical entity: dTMP
stoichiometric coefficient: 1.0

ncbitaxon 100226 36
type: UnificationXref
id: 100226
db: ncbitaxon

STATE_TRANSITION_LEFT__NADH__PLUS__H_PLUS_-_Thymine-RIGHT__NAD_PLUS_-_Dihydrothymine-_r94
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 155
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 153
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 154
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 156
left: Thymine
left: NADH + H+
interaction type: STATE_TRANSITION
right: Dihydrothymine
right: NAD+

ncbitaxon 9544 7
type: UnificationXref
id: 9544
db: ncbitaxon

ncbitaxon 7227 32
type: UnificationXref
id: 7227
db: ncbitaxon

Dihydropyrimidine dehydrogenase [NADP(+)]
type: ProteinReference
xref: PTHR43073:SF2
xref: uniprot H2PZG2 101
organism: Pan troglodytes

KNOWN_TRANSITION_OMITTED
type: InteractionVocabulary

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Methylmelonate_semialdehyde-_CoA_SH__PLUS__NAD_PLUS_-RIGHT__Methylmelonyl_CoA-_NADH__PLUS__H_PLUS_-_r98
controller: Methylmalonate Semialdehyde Dehydrogenase

ncbitaxon 3702 27
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot Q8CHR6 104
type: UnificationXref
id: Q8CHR6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Thymidine-_Pi-RIGHT__2_Deoxyribose_1_Phosphate-_Thymine-_r93
controller: Nucleoside Phosphorylase

Cytidine deaminase
type: ProteinReference
xref: PTHR11644:SF11
xref: uniprot Q22922 122
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r98 138
type: Stoichiometry
physical entity: Methylmelonate semialdehyde
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r98 139
type: Stoichiometry
physical entity: CoA-SH + NAD+
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__H2O-_Dihydrothymine-RIGHT__Beta_Ureidoisobutyrate-_r95
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r95 150
participant stoichiometry: PARTICIPANT STOICHIOMETRY r95 151
participant stoichiometry: PARTICIPANT STOICHIOMETRY r95 152
left: Dihydrothymine
left: H2O
interaction type: STATE_TRANSITION
right: Beta-Ureidoisobutyrate

PTHR11575:SF25
type: RelationshipXref
id: PTHR11575:SF25
db: PANTHER Family
relationship type: By Homology

uniprot F1N549 99
type: UnificationXref
id: F1N549
db: uniprot

PTHR43866:SF3
type: RelationshipXref
id: PTHR43866:SF3
db: PANTHER Family
relationship type: By Homology

uniprot Q9RX72 85
type: UnificationXref
id: Q9RX72
db: uniprot

PTHR43866:SF4
type: RelationshipXref
id: PTHR43866:SF4
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r98 140
type: Stoichiometry
physical entity: Methylmelonyl-CoA
stoichiometric coefficient: 1.0

Pi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r98 141
type: Stoichiometry
physical entity: NADH + H+
stoichiometric coefficient: 1.0

5'-nucleotidase ecto
type: ProteinReference
xref: PTHR11575:SF25
xref: uniprot H2QTC9 125
organism: Pan troglodytes

Dihydropyrimidinase-related protein 2
type: ProteinReference
xref: uniprot Q16555 61
xref: PTHR11647:SF56
organism: Homo sapiens

IDA
type: EvidenceCodeVocabulary

uniprot J9P8R1 93
type: UnificationXref
id: J9P8R1
db: uniprot

4-aminobutyrate aminotransferase
type: ProteinReference
xref: uniprot F1MFB7 106
xref: PTHR43206:SF1
organism: Bos taurus

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 109

ncbitaxon 83333 78
type: UnificationXref
id: 83333
db: ncbitaxon

uniprot E1BFN6 40
type: UnificationXref
id: E1BFN6
db: uniprot

uniprot Q63150 64
type: UnificationXref
id: Q63150
db: uniprot