uniprot P36013 80
type: UnificationXref
id: P36013
db: uniprot

Beta-alanine--pyruvate aminotransferase
type: ProteinReference
xref: PTHR42684:SF1
xref: uniprot Q9I700 64
organism: Pseudomonas aeruginosa

Malic enzyme
type: ProteinReference
xref: P03136
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Pyruvate metabolism.PROTEIN.GENERIC.Malic enzyme
comment: ENTITY_REFERENCE_NOTES= Long Name: Malic enzyme Synonym: Synonym not specified Accession: P03136
member entity reference: Malic enzyme
member entity reference: NADP-dependent malic enzyme
member entity reference: NAD-dependent malic enzyme, mitochondrial

NAD-dependent malic enzyme, mitochondrial
type: ProteinReference
xref: uniprot P36013 80
xref: PTHR23406:SF34
organism: Saccharomyces cerevisiae

uniprot P35558 72
type: UnificationXref
id: P35558
db: uniprot

PTHR11739:SF4
type: RelationshipXref
id: PTHR11739:SF4
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__Acetyl_CoA-_ATP__PLUS__CoA_SH-_Citrate-RIGHT__Oxaloacetate-_ADP__PLUS__Pi-_r72
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 170
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 173
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 169
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 172
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 171
left: Citrate
left: ATP + CoA-SH
left: Acetyl-CoA
interaction type: HETERODIMER_ASSOCIATION
right: Oxaloacetate
right: ADP + Pi

STATE_TRANSITION_LEFT__Oxaloacetate-RIGHT__Acetyl_CoA-_r70
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 178
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 179
left: Oxaloacetate
interaction type: STATE_TRANSITION
right: Acetyl-CoA

uniprot Q94AL9 62
type: UnificationXref
id: Q94AL9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADP_PLUS_-_Malate-RIGHT__NADPH__PLUS__H_PLUS__PLUS__CO2-_Pyruvate-_r64
controller: Malic enzyme

eco ECO:0000250 4
type: UnificationXref
id: ECO:0000250
db: eco

ncbitaxon 5722 120
type: UnificationXref
id: 5722
db: ncbitaxon

Phosphoenolpyruvate Carboxykinase
type: Protein
entity reference: Phosphoenolpyruvate Carboxykinase
comment: SPECIES_TYPE=PROTEIN

uniprot F1PV92 146
type: UnificationXref
id: F1PV92
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ETT5 88
organism: Macaca mulatta

Giardia intestinalis
type: BioSource
xref: ncbitaxon 184922 75

uniprot Q9M057 42
type: UnificationXref
id: Q9M057
db: uniprot

Pyruvate kinase PKLR
type: ProteinReference
xref: uniprot P30613 23
organism: Homo sapiens

STATE_TRANSITION_LEFT__ATP__PLUS__HCO3__-_Pyruvate-RIGHT__Oxaloacetate-_ADP__PLUS__Pi-_r67
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 183
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 182
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 180
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 181
left: Pyruvate
left: ATP + HCO3 -
interaction type: STATE_TRANSITION
right: Oxaloacetate
right: ADP + Pi

uniprot O96445 127
type: UnificationXref
id: O96445
db: uniprot

NADP-dependent malic enzyme
type: ProteinReference
xref: PTHR23406:SF17
xref: uniprot P06801 78
organism: Mus musculus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 25

Pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic
type: ProteinReference
xref: uniprot O24457 44
xref: PTHR11516:SF60
organism: Arabidopsis thaliana

uniprot Q29RK2 140
type: UnificationXref
id: Q29RK2
db: uniprot

PTHR11739:SF8
type: RelationshipXref
id: PTHR11739:SF8
db: PANTHER Family
relationship type: By Homology

uniprot Q9ZBK3 113
type: UnificationXref
id: Q9ZBK3
db: uniprot

uniprot I6XWE5 43
type: UnificationXref
id: I6XWE5
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 49

uniprot F7FI39 12
type: UnificationXref
id: F7FI39
db: uniprot

Lactate dehydrogenase isozyme 2, putative
type: ProteinReference
xref: uniprot A2G057 125
xref: PTHR23382:SF0
organism: Trichomonas vaginalis

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 71

Pyruvate carboxylase
type: ProteinReference
xref: PTHR43778:SF2
xref: uniprot A8Y4B9 130
organism: Caenorhabditis briggsae

Putative citrate synthase 2
type: ProteinReference
xref: PTHR11739:SF23
xref: uniprot P9WPD3 153
organism: Mycobacterium tuberculosis

Putative citrate synthase
type: ProteinReference
xref: PTHR11739:SF23
xref: uniprot Q9K3V6 159
organism: Streptomyces coelicolor

uniprot P20007 70
type: UnificationXref
id: P20007
db: uniprot

uniprot Q8ZUR8 58
type: UnificationXref
id: Q8ZUR8
db: uniprot

uniprot F1P6G9 131
type: UnificationXref
id: F1P6G9
db: uniprot

Citramalyl-CoA lyase, mitochondrial
type: ProteinReference
xref: uniprot Q8N0X4 99
organism: Homo sapiens

uniprot P00890 148
type: UnificationXref
id: P00890
db: uniprot

By Homology
type: RelationshipTypeVocabulary

Malate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

eco ECO:0000303 63
type: UnificationXref
id: ECO:0000303
db: eco

Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
type: ProteinReference
xref: PTHR11561:SF1
xref: uniprot F6ZDT7 67
organism: Macaca mulatta

ncbitaxon 190304 102
type: UnificationXref
id: 190304
db: ncbitaxon

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 152

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 129

ncbitaxon 39947 57
type: UnificationXref
id: 39947
db: ncbitaxon

ncbitaxon 284812 55
type: UnificationXref
id: 284812
db: ncbitaxon

Phosphoenolpyruvate carboxykinase [GTP]
type: ProteinReference
xref: uniprot P20007 70
xref: PTHR11561:SF0
organism: Drosophila melanogaster

Pyruvate kinase
type: ProteinReference
xref: PTHR11817:SF3
xref: uniprot Q23539 31
organism: Caenorhabditis elegans

Citrate lyase subunit beta-like protein
type: ProteinReference
xref: uniprot P9WPE1 96
organism: Mycobacterium tuberculosis

uniprot P32327 137
type: UnificationXref
id: P32327
db: uniprot

L-lactate dehydrogenase
type: ProteinReference
xref: uniprot O96445 127
xref: PTHR23382:SF0
organism: Trichomonas vaginalis

ATP-citrate synthase
type: ProteinReference
xref: uniprot F6ZC40 86
organism: Monodelphis domestica

uniprot A2FIP9 123
type: UnificationXref
id: A2FIP9
db: uniprot

Malic enzyme
type: Protein
entity reference: Malic enzyme
comment: SPECIES_TYPE=PROTEIN

Phosphoenolpyruvate Carboxykinase
type: ProteinReference
xref: P03135
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Phosphoenolpyruvate Carboxykinase Synonym: PEPCK Accession: P03135
comment: ENTITY_REFERENCE_ID_DESC=Pyruvate metabolism.PROTEIN.GENERIC.Phosphoenolpyruvate_br_Carboxykinase
member entity reference: Phosphoenolpyruvate carboxykinase 1
member entity reference: Phosphoenolpyruvate carboxykinase [GTP]
member entity reference: Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
member entity reference: PCK1 isoform 1

uniprot A8BE38 74
type: UnificationXref
id: A8BE38
db: uniprot

uniprot P73534 27
type: UnificationXref
id: P73534
db: uniprot

uniprot Q9RSB9 109
type: UnificationXref
id: Q9RSB9
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 3

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 11

uniprot P11498 136
type: UnificationXref
id: P11498
db: uniprot

Pyruvate kinase
type: ProteinReference
xref: uniprot Q9M044 41
xref: PTHR11817:SF34
organism: Arabidopsis thaliana

Lactate dehydrogenase isozyme 2, putative
type: ProteinReference
xref: uniprot A2EFE2 119
xref: PTHR23382:SF0
organism: Trichomonas vaginalis

uniprot Q8N0X4 99
type: UnificationXref
id: Q8N0X4
db: uniprot

NAD+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9M044 41
type: UnificationXref
id: Q9M044
db: uniprot

Citrate synthase, mitochondrial
type: ProteinReference
xref: uniprot Q9CZU6 158
xref: PTHR11739:SF8
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r75 165
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r75 166
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

Pyruvate carboxylase, mitochondrial
type: ProteinReference
xref: PTHR43778:SF2
xref: uniprot Q05920 139
organism: Mus musculus

uniprot Q9FNN1 37
type: UnificationXref
id: Q9FNN1
db: uniprot

uniprot Q8VHF5 156
type: UnificationXref
id: Q8VHF5
db: uniprot

uniprot A2EFE2 119
type: UnificationXref
id: A2EFE2
db: uniprot

PTHR43778:SF2
type: RelationshipXref
id: PTHR43778:SF2
db: PANTHER Family
relationship type: By Homology

Malate Dehydrogenase
type: Protein
entity reference: Malate Dehydrogenase
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NAD_PLUS_-_Malate-RIGHT__Oxaloacetate-_NADPH__PLUS__H_PLUS_-_r66
controller: Malate Dehydrogenase

PTHR45688:SF13
type: RelationshipXref
id: PTHR45688:SF13
db: PANTHER Family
relationship type: By Homology

Pyruvate kinase
type: ProteinReference
xref: PTHR11817:SF34
xref: uniprot Q9M057 42
organism: Arabidopsis thaliana

Pyruvate carboxylase 1
type: ProteinReference
xref: PTHR43778:SF2
xref: uniprot P11154 135
organism: Saccharomyces cerevisiae

ncbitaxon 100226 61
type: UnificationXref
id: 100226
db: ncbitaxon

uniprot Q58820 116
type: UnificationXref
id: Q58820
db: uniprot

PARTICIPANT STOICHIOMETRY r75 164
type: Stoichiometry
physical entity: Oxaloacetate
stoichiometric coefficient: 1.0

Pyruvate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Pyruvate carboxylase, mitochondrial
type: ProteinReference
xref: PTHR43778:SF2
xref: uniprot Q29RK2 140
organism: Bos taurus

Citrate synthase, mitochondrial
type: ProteinReference
xref: uniprot Q29RK1 154
xref: PTHR11739:SF8
organism: Bos taurus

Pyruvate dehydrogenase E1 component subunit alpha
type: ProteinReference
xref: PTHR11516:SF60
xref: uniprot P74490 53
organism: Synechocystis

eco ECO:0000353 149
type: UnificationXref
id: ECO:0000353
db: eco

uniprot A8XDI6 84
type: UnificationXref
id: A8XDI6
db: uniprot

Citrate synthase
type: ProteinReference
xref: uniprot Q8ZSU1 157
xref: PTHR11739:SF4
organism: Pyrobaculum aerophilum

Citrate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9031 16
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot Q99Q47 105
type: UnificationXref
id: Q99Q47
db: uniprot

Pyruvate kinase
type: ProteinReference
xref: PTHR11817:SF15
xref: uniprot A5D984 6
organism: Bos taurus

Citrate synthase
type: ProteinReference
xref: uniprot P0ABH7 150
xref: PTHR42871:SF1
organism: Escherichia coli

Pyruvate carboxylase
type: ProteinReference
xref: PTHR43778:SF2
xref: uniprot Q9UUE1 144
organism: Schizosaccharomyces pombe

STATE_TRANSITION_LEFT__GTP-_Acetyl_CoA-RIGHT__Phosphoenolpyruvate-_GDP__PLUS__CO2-_r76
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 161
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 163
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 162
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 160
left: GTP
left: Acetyl-CoA
interaction type: STATE_TRANSITION
right: GDP + CO2
right: Phosphoenolpyruvate

eco ECO:0000501 59
type: UnificationXref
id: ECO:0000501
db: eco

Lactate Dehydrogenase
type: ProteinReference
xref: P03139
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Lactate Dehydrogenase Synonym: LDH Accession: P03139
comment: ENTITY_REFERENCE_ID_DESC=Pyruvate metabolism.PROTEIN.GENERIC.Lactate Dehydrogenase
member entity reference: L-lactate dehydrogenase, putative
member entity reference: L-lactate dehydrogenase
member entity reference: Lactate dehydrogenase isozyme 2
member entity reference: Lactate dehydrogenase isozyme 2, putative

uniprot Q9FFP6 35
type: UnificationXref
id: Q9FFP6
db: uniprot

PARTICIPANT STOICHIOMETRY r73 167
type: Stoichiometry
physical entity: Alanine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r73 168
type: Stoichiometry
physical entity: Pyruvate
stoichiometric coefficient: 1.0

P03139
type: UnificationXref
id: P03139
db: PANTHER Pathway Component

Citramalyl-CoA lyase, mitochondrial
type: ProteinReference
xref: uniprot Q5I0K3 98
organism: Rattus norvegicus

uniprot P35486 51
type: UnificationXref
id: P35486
db: uniprot

Lactate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q23539 31
type: UnificationXref
id: Q23539
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NAD_PLUS___PLUS__CoA_SH-_Pyruvate-RIGHT__Acetyl_CoA-_NADH__PLUS__CO2-_r68
controller: Pyruvate Dehydrogenase

Malic enzyme
type: ProteinReference
xref: PTHR23406:SF17
xref: uniprot G7MPT7 76
organism: Macaca mulatta

PTHR42871:SF1
type: RelationshipXref
id: PTHR42871:SF1
db: PANTHER Family
relationship type: By Homology

Pyruvate carboxylase 1
type: ProteinReference
xref: PTHR43778:SF2
xref: uniprot O17732 134
organism: Caenorhabditis elegans

Citrate lyase subunit beta-like protein
type: ProteinReference
xref: uniprot Q9RUZ0 111
organism: Deinococcus radiodurans

Aminotransefrase
type: Protein
entity reference: Aminotransefrase
comment: SPECIES_TYPE=PROTEIN

PTHR11516:SF2
type: RelationshipXref
id: PTHR11516:SF2
db: PANTHER Family
relationship type: By Homology

Citrate (Pro-3S)-lyase
type: ProteinReference
xref: uniprot Q9HRM8 106
organism: Halobacterium salinarum

Lactate dehydrogenase isozyme 2
type: ProteinReference
xref: uniprot A2FYF4 124
xref: PTHR23382:SF0
organism: Trichomonas vaginalis

P03141
type: UnificationXref
id: P03141
db: PANTHER Pathway Component

P03140
type: UnificationXref
id: P03140
db: PANTHER Pathway Component

Citrate Synthetase
type: ProteinReference
xref: P03141
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Citrate Synthetase Synonym: Synonym not specified Accession: P03141
comment: ENTITY_REFERENCE_ID_DESC=Pyruvate metabolism.PROTEIN.GENERIC.Citrate Synthetase
member entity reference: Citrate synthase, mitochondrial
member entity reference: Citrate synthase
member entity reference: Putative citrate synthase
member entity reference: Putative citrate synthase 2

Pyruvate metabolism
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__Oxaloacetate-_Acetyl_CoA-RIGHT__Citrate-_r75
pathway component: STATE_TRANSITION_LEFT__GTP-_Acetyl_CoA-RIGHT__Phosphoenolpyruvate-_GDP__PLUS__CO2-_r76
pathway component: STATE_TRANSITION_LEFT__NAD_PLUS_-_Malate-RIGHT__Oxaloacetate-_NADPH__PLUS__H_PLUS_-_r66
pathway component: STATE_TRANSITION_LEFT__NAD_PLUS___PLUS__CoA_SH-_Pyruvate-RIGHT__Acetyl_CoA-_NADH__PLUS__CO2-_r68
pathway component: STATE_TRANSITION_LEFT__Pyruvate-RIGHT__Alanine-_r65
pathway component: HETERODIMER_ASSOCIATION_LEFT__Acetyl_CoA-_ATP__PLUS__CoA_SH-_Citrate-RIGHT__Oxaloacetate-_ADP__PLUS__Pi-_r72
pathway component: STATE_TRANSITION_LEFT__ATP-_Phosphoenolpyruvate-RIGHT__ADP-_Pyruvate-_r62
pathway component: STATE_TRANSITION_LEFT__NAD_PLUS_-_Lactate-RIGHT__NADPH__PLUS__H_PLUS_-_Pyruvate-_r63
pathway component: STATE_TRANSITION_LEFT__NADP_PLUS_-_Malate-RIGHT__NADPH__PLUS__H_PLUS__PLUS__CO2-_Pyruvate-_r64
pathway component: STATE_TRANSITION_LEFT__Oxaloacetate-RIGHT__Acetyl_CoA-_r70
pathway component: STATE_TRANSITION_LEFT__Alanine-RIGHT__Pyruvate-_r73
pathway component: STATE_TRANSITION_LEFT__ATP__PLUS__HCO3__-_Pyruvate-RIGHT__Oxaloacetate-_ADP__PLUS__Pi-_r67
xref: PANTHER Pathway P02772 1
comment: MODEL_NOTES= Not only does pyruvate join the glycolytic pathway to the TCA cycle, but it is also linked to amino acid metabolism by the transamination reaction and to lipid metabolism by its decarboxylation to acetyl-coA. Another imporatnt feature of the role played by pyruvate is the fact that it is produced in the cytoplasm but both its decarboxylation to acetyl-coA and its carboxylation oxaloacetate take place in the mitochondrial matrix. Thus, pyruvate provides the link between metabolism in the cytoplasm and the pathways that are restricted to the mitochondrial matrix. free text=Biochemiscal Pathways - An Atlas of Biochemistry and Molecular Biology Edited by Gerhard Michal free text=Color Atlas of Biochemistry by Jan Koolman and Klaus-Heinrich Rohm free text=Human Metabolism by Ramsey Bronk

Putative pyruvate dehydrogenase alpha subunit
type: ProteinReference
xref: uniprot Q9K3H0 60
xref: PTHR11516:SF2
organism: Streptomyces coelicolor

uniprot Q6Z5N4 56
type: UnificationXref
id: Q6Z5N4
db: uniprot

uniprot P0ABH7 150
type: UnificationXref
id: P0ABH7
db: uniprot

L-sulfolactate dehydrogenase
type: ProteinReference
xref: uniprot Q58820 116
xref: PTHR11091:SF0
organism: Methanocaldococcus jannaschii

Pyruvate kinase PKM
type: ProteinReference
xref: PTHR11817:SF15
xref: uniprot P14618 21
organism: Homo sapiens

uniprot Q9HRM8 106
type: UnificationXref
id: Q9HRM8
db: uniprot

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 115

Bos taurus
type: BioSource
xref: ncbitaxon 9913 7

STATE_TRANSITION_LEFT__NAD_PLUS_-_Lactate-RIGHT__NADPH__PLUS__H_PLUS_-_Pyruvate-_r63
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 195
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 196
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 197
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 194
left: Lactate
left: NAD+
interaction type: STATE_TRANSITION
right: NADPH + H+
right: Pyruvate

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 13

uniprot Q91V92 103
type: UnificationXref
id: Q91V92
db: uniprot

Phosphoenolpyruvate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Citrate synthase
type: ProteinReference
xref: uniprot A0A1D5R3J3 145
xref: PTHR11739:SF8
organism: Macaca mulatta

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 59

Uncharacterized oxidoreductase YjmC
type: ProteinReference
xref: PTHR11091:SF0
xref: uniprot O34736 114
organism: Bacillus subtilis

PARTICIPANT STOICHIOMETRY r62 200
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r63 196
type: Stoichiometry
physical entity: NADPH + H+
stoichiometric coefficient: 1.0

ATP-citrate synthase
type: ProteinReference
xref: uniprot F1Q3V2 85
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r62 201
type: Stoichiometry
physical entity: Pyruvate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r63 195
type: Stoichiometry
physical entity: Lactate
stoichiometric coefficient: 1.0

ncbitaxon 367110 152
type: UnificationXref
id: 367110
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r63 197
type: Stoichiometry
physical entity: Pyruvate
stoichiometric coefficient: 1.0

Alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial
type: ProteinReference
xref: PTHR45688:SF13
xref: uniprot Q94AL9 62
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r67 180
type: Stoichiometry
physical entity: ATP + HCO3 -
stoichiometric coefficient: 1.0

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Pyruvate kinase
type: ProteinReference
xref: PTHR11817:SF3
xref: uniprot Q9HW72 38
organism: Pseudomonas aeruginosa

PARTICIPANT STOICHIOMETRY r67 181
type: Stoichiometry
physical entity: Pyruvate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r63 194
type: Stoichiometry
physical entity: NAD+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r67 182
type: Stoichiometry
physical entity: Oxaloacetate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r67 183
type: Stoichiometry
physical entity: ADP + Pi
stoichiometric coefficient: 1.0

uniprot P9WPE1 96
type: UnificationXref
id: P9WPE1
db: uniprot

uniprot P9WPD3 153
type: UnificationXref
id: P9WPD3
db: uniprot

uniprot F7ETT5 88
type: UnificationXref
id: F7ETT5
db: uniprot

ADP + Pi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 272561 46
type: UnificationXref
id: 272561
db: ncbitaxon

ATP-citrate synthase
type: ProteinReference
xref: uniprot Q32PF2 97
organism: Bos taurus

PTHR11817:SF84
type: RelationshipXref
id: PTHR11817:SF84
db: PANTHER Family
relationship type: By Homology

ncbitaxon 10116 18
type: UnificationXref
id: 10116
db: ncbitaxon

PCK1 isoform 1
type: ProteinReference
xref: uniprot H2QKN1 68
xref: PTHR11561:SF1
organism: Pan troglodytes

ncbitaxon 10090 25
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot P11980 17
type: UnificationXref
id: P11980
db: uniprot

uniprot F6ZC40 86
type: UnificationXref
id: F6ZC40
db: uniprot

ncbitaxon 9615 66
type: UnificationXref
id: 9615
db: ncbitaxon

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 66

uniprot Q93167 104
type: UnificationXref
id: Q93167
db: uniprot

uniprot P16387 48
type: UnificationXref
id: P16387
db: uniprot

Citrate synthase
type: ProteinReference
xref: PTHR11739:SF8
xref: uniprot F1PV92 146
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Phosphoenolpyruvate-RIGHT__ADP-_Pyruvate-_r62
controller: Pyruvate Kinase

PTHR11817:SF3
type: RelationshipXref
id: PTHR11817:SF3
db: PANTHER Family
relationship type: By Homology

Citrate synthase
type: ProteinReference
xref: PTHR11739:SF8
xref: uniprot Q80X68 155
organism: Mus musculus

Citramalyl-CoA lyase, mitochondrial
type: ProteinReference
xref: uniprot Q8R4N0 100
organism: Mus musculus

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 16

uniprot H2R399 133
type: UnificationXref
id: H2R399
db: uniprot

ncbitaxon 9606 22
type: UnificationXref
id: 9606
db: ncbitaxon

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 34

PTHR11817:SF79
type: RelationshipXref
id: PTHR11817:SF79
db: PANTHER Family
relationship type: By Homology

uniprot Q9RUZ0 111
type: UnificationXref
id: Q9RUZ0
db: uniprot

uniprot P13697 79
type: UnificationXref
id: P13697
db: uniprot

STATE_TRANSITION_LEFT__ATP-_Phosphoenolpyruvate-RIGHT__ADP-_Pyruvate-_r62
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 199
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 201
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 198
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 200
left: ATP
left: Phosphoenolpyruvate
interaction type: STATE_TRANSITION
right: Pyruvate
right: ADP

ncbitaxon 8364 11
type: UnificationXref
id: 8364
db: ncbitaxon

Pyruvate kinase PKM
type: ProteinReference
xref: PTHR11817:SF101
xref: uniprot P11980 17
organism: Rattus norvegicus

NADP-dependent malic enzyme
type: ProteinReference
xref: PTHR23406:SF17
xref: uniprot P48163 81
organism: Homo sapiens

uniprot P12928 20
type: UnificationXref
id: P12928
db: uniprot

PARTICIPANT STOICHIOMETRY r62 198
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r62 199
type: Stoichiometry
physical entity: Phosphoenolpyruvate
stoichiometric coefficient: 1.0

Pyruvate Dehydrogenase
type: ProteinReference
xref: P03133
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Pyruvate metabolism.PROTEIN.GENERIC.Pyruvate_br_Dehydrogenase
comment: ENTITY_REFERENCE_NOTES= Long Name: Pyruvate Dehydrogenase Synonym: Synonym not specified Accession: P03133
member entity reference: Pyruvate dehydrogenase E1 component subunit alpha
member entity reference: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
member entity reference: Putative pyruvate dehydrogenase alpha subunit
member entity reference: Pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic
member entity reference: Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
member entity reference: Probable dehydrogenase
member entity reference: Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
member entity reference: Pyruvate dehydrogenase E1 alpha subunit
member entity reference: Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 61

Aminotransefrase
type: ProteinReference
xref: P03134
standard name: Aminotransferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Pyruvate metabolism.PROTEIN.GENERIC.Aminotransefrase
comment: ENTITY_REFERENCE_NOTES= Long Name: Aminotransferase Synonym: Synonym not specified Accession: P03134
member entity reference: Beta-alanine--pyruvate aminotransferase
member entity reference: Alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial

uniprot Q9S2U9 112
type: UnificationXref
id: Q9S2U9
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

Malate Dehydrogenase
type: ProteinReference
xref: P03138
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Malate Dehydrogenase Synonym: Synonym not specified Accession: P03138
comment: ENTITY_REFERENCE_ID_DESC=Pyruvate metabolism.PROTEIN.GENERIC.Malate_br_Dehydrogenase
member entity reference: Delta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase
member entity reference: Uncharacterized oxidoreductase YjmC
member entity reference: L-sulfolactate dehydrogenase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP__PLUS__HCO3__-_Pyruvate-RIGHT__Oxaloacetate-_ADP__PLUS__Pi-_r67
controller: Pyruvate Carboxylase

IDA
type: EvidenceCodeVocabulary

Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
type: ProteinReference
xref: uniprot P29803 50
organism: Homo sapiens

NADPH + H++ CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Pyruvate kinase
type: ProteinReference
xref: PTHR11817:SF34
xref: uniprot Q9LU95 40
organism: Arabidopsis thaliana

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NAD_PLUS_-_Lactate-RIGHT__NADPH__PLUS__H_PLUS_-_Pyruvate-_r63
controller: Lactate Dehydrogenase

GDP + CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Lactate Dehydrogenase
type: Protein
entity reference: Lactate Dehydrogenase
comment: SPECIES_TYPE=PROTEIN

PTHR11091:SF0
type: RelationshipXref
id: PTHR11091:SF0
db: PANTHER Family
relationship type: By Homology

Pyruvate dehydrogenase E1 alpha subunit
type: ProteinReference
xref: uniprot Q8ZUR8 58
xref: PTHR11516:SF41
organism: Pyrobaculum aerophilum

PARTICIPANT STOICHIOMETRY r65 188
type: Stoichiometry
physical entity: Pyruvate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r70 178
type: Stoichiometry
physical entity: Oxaloacetate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r65 189
type: Stoichiometry
physical entity: Alanine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r70 179
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Citrate synthase, mitochondrial
type: ProteinReference
xref: PTHR11739:SF8
xref: uniprot Q8VHF5 156
organism: Rattus norvegicus

Citrate lyase beta chain
type: ProteinReference
xref: uniprot Q8RDW5 101
organism: Fusobacterium nucleatum

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 9

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 32

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Acetyl_CoA-_ATP__PLUS__CoA_SH-_Citrate-RIGHT__Oxaloacetate-_ADP__PLUS__Pi-_r72
controller: Citrate Lyase

L-lactate dehydrogenase
type: ProteinReference
xref: uniprot Q76NM3 128
xref: PTHR11540:SF16
organism: Plasmodium falciparum

ATP-citrate synthase
type: ProteinReference
xref: uniprot H2R314 90
organism: Pan troglodytes

Acetyl-CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
type: ProteinReference
xref: uniprot Q9Z2V4 73
xref: PTHR11561:SF1
organism: Mus musculus

ncbitaxon 3702 36
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot P74490 53
type: UnificationXref
id: P74490
db: uniprot

CLYBL protein
type: ProteinReference
xref: uniprot A6QL68 83
organism: Bos taurus

uniprot P34085 151
type: UnificationXref
id: P34085
db: uniprot

Citrate lyase beta like
type: ProteinReference
xref: uniprot H2R0Q3 89
organism: Pan troglodytes

uniprot Q5B4R8 141
type: UnificationXref
id: Q5B4R8
db: uniprot

ncbitaxon 83333 93
type: UnificationXref
id: 83333
db: ncbitaxon

Pyruvate carboxylase, mitochondrial
type: ProteinReference
xref: PTHR43778:SF2
xref: uniprot P11498 136
organism: Homo sapiens

P03135
type: UnificationXref
id: P03135
db: PANTHER Pathway Component

P03136
type: UnificationXref
id: P03136
db: PANTHER Pathway Component

uniprot A5D984 6
type: UnificationXref
id: A5D984
db: uniprot

P03137
type: UnificationXref
id: P03137
db: PANTHER Pathway Component

P03138
type: UnificationXref
id: P03138
db: PANTHER Pathway Component

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 57

Pyruvate kinase
type: ProteinReference
xref: uniprot P9WKE5 29
xref: PTHR11817:SF3
organism: Mycobacterium tuberculosis

P03132
type: UnificationXref
id: P03132
db: PANTHER Pathway Component

P03133
type: UnificationXref
id: P03133
db: PANTHER Pathway Component

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 39

P03134
type: UnificationXref
id: P03134
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Oxaloacetate-_Acetyl_CoA-RIGHT__Citrate-_r75
controller: Citrate Synthetase

uniprot P53396 95
type: UnificationXref
id: P53396
db: uniprot

ncbitaxon 184922 75
type: UnificationXref
id: 184922
db: ncbitaxon

PANTHER Pathway P02772 1
type: UnificationXref
id: P02772
db: PANTHER Pathway

Conserved protein
type: ProteinReference
xref: uniprot I6YF40 91
organism: Mycobacterium tuberculosis

uniprot A8Y4B9 130
type: UnificationXref
id: A8Y4B9
db: uniprot

PARTICIPANT STOICHIOMETRY r64 190
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 191
type: Stoichiometry
physical entity: Malate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 192
type: Stoichiometry
physical entity: NADPH + H++ CO2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 193
type: Stoichiometry
physical entity: Pyruvate
stoichiometric coefficient: 1.0

uniprot Q9HW72 38
type: UnificationXref
id: Q9HW72
db: uniprot

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 107

uniprot P06801 78
type: UnificationXref
id: P06801
db: uniprot

Pyruvate kinase
type: ProteinReference
xref: PTHR11817:SF15
xref: uniprot A0A2I3TKQ7 2
organism: Pan troglodytes

uniprot A2FIP8 121
type: UnificationXref
id: A2FIP8
db: uniprot

uniprot F1Q3V2 85
type: UnificationXref
id: F1Q3V2
db: uniprot

PARTICIPANT STOICHIOMETRY r66 184
type: Stoichiometry
physical entity: NAD+
stoichiometric coefficient: 1.0

Pyruvate carboxylase
type: ProteinReference
xref: PTHR43778:SF2
xref: uniprot F1P6G9 131
organism: Canis lupus familiaris

uniprot Q8RDW5 101
type: UnificationXref
id: Q8RDW5
db: uniprot

PARTICIPANT STOICHIOMETRY r68 176
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot Q93167 104
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r68 177
type: Stoichiometry
physical entity: NADH + CO2
stoichiometric coefficient: 1.0

PTHR11516:SF60
type: RelationshipXref
id: PTHR11516:SF60
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r68 174
type: Stoichiometry
physical entity: NAD+ + CoA-SH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r68 175
type: Stoichiometry
physical entity: Pyruvate
stoichiometric coefficient: 1.0

uniprot H2QKN1 68
type: UnificationXref
id: H2QKN1
db: uniprot

ncbitaxon 224308 115
type: UnificationXref
id: 224308
db: ncbitaxon

Oxaloacetate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
type: ProteinReference
xref: uniprot P16387 48
xref: PTHR11516:SF60
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r66 186
type: Stoichiometry
physical entity: Oxaloacetate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r66 185
type: Stoichiometry
physical entity: Malate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r66 187
type: Stoichiometry
physical entity: NADPH + H+
stoichiometric coefficient: 1.0

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 46

PTHR11739:SF23
type: RelationshipXref
id: PTHR11739:SF23
db: PANTHER Family
relationship type: By Homology

eco ECO:0000304 19
type: UnificationXref
id: ECO:0000304
db: eco

ncbitaxon 178306 34
type: UnificationXref
id: 178306
db: ncbitaxon

uniprot H2QTC2 77
type: UnificationXref
id: H2QTC2
db: uniprot

GTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9UUE1 144
type: UnificationXref
id: Q9UUE1
db: uniprot

uniprot F1PAM0 65
type: UnificationXref
id: F1PAM0
db: uniprot

Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
type: ProteinReference
xref: PTHR11561:SF1
xref: uniprot P35558 72
organism: Homo sapiens

Pyruvate kinase PKLR
type: ProteinReference
xref: uniprot P12928 20
organism: Rattus norvegicus

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 28

Delta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase
type: ProteinReference
xref: uniprot Q9I492 118
xref: PTHR11091:SF0
organism: Pseudomonas aeruginosa

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 4

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 149

uniprot F6W2Y6 10
type: UnificationXref
id: F6W2Y6
db: uniprot

Pyruvate carboxylase
type: ProteinReference
xref: uniprot Q5B4R8 141
xref: PTHR43778:SF2
organism: Emericella nidulans

PTHR11516:SF41
type: RelationshipXref
id: PTHR11516:SF41
db: PANTHER Family
relationship type: By Homology

Pyruvate kinase PKM
type: ProteinReference
xref: PTHR11817:SF15
xref: uniprot P52480 24
organism: Mus musculus

Pyruvate carboxylase 2
type: ProteinReference
xref: PTHR43778:SF2
xref: uniprot P32327 137
organism: Saccharomyces cerevisiae

uniprot Q29RK1 154
type: UnificationXref
id: Q29RK1
db: uniprot

Phosphoenolpyruvate carboxykinase 1
type: ProteinReference
xref: uniprot F1PAM0 65
xref: PTHR11561:SF1
organism: Canis lupus familiaris

L-lactate dehydrogenase, putative
type: ProteinReference
xref: PTHR23382:SF0
xref: uniprot A2GET8 126
organism: Trichomonas vaginalis

uniprot Q8ZYE0 33
type: UnificationXref
id: Q8ZYE0
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 87

uniprot P52873 138
type: UnificationXref
id: P52873
db: uniprot

PTHR23406:SF17
type: RelationshipXref
id: PTHR23406:SF17
db: PANTHER Family
relationship type: By Homology

ncbitaxon 1111708 28
type: UnificationXref
id: 1111708
db: ncbitaxon

uniprot A2GET8 126
type: UnificationXref
id: A2GET8
db: uniprot

uniprot P08559 47
type: UnificationXref
id: P08559
db: uniprot

uniprot P52480 24
type: UnificationXref
id: P52480
db: uniprot

Putative citrate lyase beta chain
type: ProteinReference
xref: uniprot Q9S2U9 112
organism: Streptomyces coelicolor

Alanine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9I562 108
type: UnificationXref
id: Q9I562
db: uniprot

ncbitaxon 243230 110
type: UnificationXref
id: 243230
db: ncbitaxon

ATP + CoA-SH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Pyruvate carboxylase, mitochondrial
type: ProteinReference
xref: uniprot P52873 138
xref: PTHR43778:SF2
organism: Rattus norvegicus

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 55

ATP-citrate synthase
type: ProteinReference
xref: uniprot Q91V92 103
organism: Mus musculus

PTHR11817:SF15
type: RelationshipXref
id: PTHR11817:SF15
db: PANTHER Family
relationship type: By Homology

Pyruvate kinase
type: ProteinReference
xref: PTHR11817:SF3
xref: uniprot A8X188 8
organism: Caenorhabditis briggsae

Putative lysase
type: ProteinReference
xref: uniprot Q99Q47 105
organism: Streptomyces coelicolor

uniprot A2G057 125
type: UnificationXref
id: A2G057
db: uniprot

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
type: ProteinReference
xref: uniprot P08559 47
organism: Homo sapiens

L-lactate dehydrogenase, putative
type: ProteinReference
xref: uniprot A2FIP8 121
xref: PTHR23382:SF0
organism: Trichomonas vaginalis

L-lactate dehydrogenase, putative
type: ProteinReference
xref: uniprot A2FIP9 123
xref: PTHR23382:SF0
organism: Trichomonas vaginalis

uniprot Q32PF2 97
type: UnificationXref
id: Q32PF2
db: uniprot

ncbitaxon 208964 39
type: UnificationXref
id: 208964
db: ncbitaxon

STATE_TRANSITION_LEFT__NAD_PLUS_-_Malate-RIGHT__Oxaloacetate-_NADPH__PLUS__H_PLUS_-_r66
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 185
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 186
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 187
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 184
left: NAD+
left: Malate
interaction type: STATE_TRANSITION
right: NADPH + H+
right: Oxaloacetate

PTHR23406:SF34
type: RelationshipXref
id: PTHR23406:SF34
db: PANTHER Family
relationship type: By Homology

Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
type: ProteinReference
xref: PTHR11516:SF60
xref: uniprot Q10489 54
organism: Schizosaccharomyces pombe

Protein CBG11570
type: ProteinReference
xref: uniprot A8XDI6 84
organism: Caenorhabditis briggsae

Pyruvate carboxylase
type: ProteinReference
xref: PTHR43778:SF2
xref: uniprot F6SC45 132
organism: Macaca mulatta

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 110

NADP+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 22

uniprot P0A9I1 92
type: UnificationXref
id: P0A9I1
db: uniprot

NADP-dependent malic enzyme
type: ProteinReference
xref: PTHR23406:SF17
xref: uniprot P13697 79
organism: Rattus norvegicus

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 117

PTHR11817:SF34
type: RelationshipXref
id: PTHR11817:SF34
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Alanine-RIGHT__Pyruvate-_r73
controller: Aminotransefrase

uniprot P14618 21
type: UnificationXref
id: P14618
db: uniprot

Pyruvate Dehydrogenase
type: Protein
entity reference: Pyruvate Dehydrogenase
comment: SPECIES_TYPE=PROTEIN

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 36

Pyruvate Kinase
type: ProteinReference
xref: P03132
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Pyruvate Kinase Synonym: PK Accession: P03132
comment: ENTITY_REFERENCE_ID_DESC=Pyruvate metabolism.PROTEIN.GENERIC.Pyruvate Kinase
member entity reference: Pyruvate kinase
member entity reference: Pyruvate kinase PKLR
member entity reference: Pyruvate kinase PKM
member entity reference: Pyruvate kinase 2

uniprot Q8R4N0 100
type: UnificationXref
id: Q8R4N0
db: uniprot

uniprot P16638 94
type: UnificationXref
id: P16638
db: uniprot

Probable pyruvate carboxylase
type: ProteinReference
xref: PTHR48095:SF3
xref: uniprot Q9I3U4 143
organism: Pseudomonas aeruginosa

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 30

Pyruvate carboxylase
type: ProteinReference
xref: uniprot H2R399 133
xref: PTHR43778:SF2
organism: Pan troglodytes

Pyruvate Carboxylase
type: ProteinReference
xref: P03140
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Pyruvate metabolism.PROTEIN.GENERIC.Pyruvate Carboxylase
comment: ENTITY_REFERENCE_NOTES= Long Name: Pyruvate Carboxylase Synonym: Synonym not specified Accession: P03140
member entity reference: Pyruvate carboxylase 1
member entity reference: Pyruvate carboxylase, mitochondrial
member entity reference: Pyruvate carboxylase
member entity reference: Pyruvate carboxylase 2
member entity reference: Probable pyruvate carboxylase

uniprot Q76NM3 128
type: UnificationXref
id: Q76NM3
db: uniprot

Pyruvate kinase
type: ProteinReference
xref: uniprot H2RBP4 14
organism: Pan troglodytes

uniprot P53657 26
type: UnificationXref
id: P53657
db: uniprot

Trichomonas vaginalis
type: BioSource
xref: ncbitaxon 5722 120

PTHR11561:SF0
type: RelationshipXref
id: PTHR11561:SF0
db: PANTHER Family
relationship type: By Homology

uniprot Q9I700 64
type: UnificationXref
id: Q9I700
db: uniprot

uniprot O17732 134
type: UnificationXref
id: O17732
db: uniprot

PTHR11561:SF1
type: RelationshipXref
id: PTHR11561:SF1
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9913 7
type: UnificationXref
id: 9913
db: ncbitaxon

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 93

Probable acyl-CoA lyase beta chain
type: ProteinReference
xref: uniprot Q9I562 108
organism: Pseudomonas aeruginosa

Pyruvate kinase PKM
type: ProteinReference
xref: PTHR11817:SF15
xref: uniprot P00548 15
organism: Gallus gallus

STATE_TRANSITION_LEFT__Pyruvate-RIGHT__Alanine-_r65
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 189
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 188
left: Pyruvate
interaction type: STATE_TRANSITION
right: Alanine

Citrate Lyase
type: ProteinReference
xref: P03137
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Pyruvate metabolism.PROTEIN.GENERIC.Citrate Lyase
comment: ENTITY_REFERENCE_NOTES= Long Name: Citrate Lyase Synonym: Synonym not specified Accession: P03137
member entity reference: Citrate lyase, beta subunit
member entity reference: Citrate lyase beta like
member entity reference: Citrate (Pro-3S)-lyase
member entity reference: Citrate lyase subunit beta-like protein
member entity reference: ATP-citrate synthase
member entity reference: Citrate lyase subunit beta
member entity reference: Probable acyl-CoA lyase beta chain
member entity reference: Uncharacterized protein
member entity reference: Putative citratelyase
member entity reference: Conserved protein
member entity reference: Citramalyl-CoA lyase, mitochondrial
member entity reference: Citrate lyase beta chain
member entity reference: Putative citrate lyase beta chain
member entity reference: Putative lysase
member entity reference: CLYBL protein
member entity reference: Protein CBG11570

Malic enzyme
type: ProteinReference
xref: PTHR23406:SF34
xref: uniprot A8BE38 74
organism: Giardia intestinalis

uniprot A0A1D5PSE5 82
type: UnificationXref
id: A0A1D5PSE5
db: uniprot

Citrate synthase, mitochondrial
type: ProteinReference
xref: uniprot P00890 148
xref: PTHR11739:SF8
organism: Saccharomyces cerevisiae

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
type: ProteinReference
xref: uniprot P35486 51
organism: Mus musculus

Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
type: ProteinReference
xref: uniprot P35487 52
organism: Mus musculus

uniprot P48163 81
type: UnificationXref
id: P48163
db: uniprot

Pyruvate kinase
type: ProteinReference
xref: uniprot Q9FFP6 35
xref: PTHR11817:SF79
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r72 171
type: Stoichiometry
physical entity: Citrate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r72 172
type: Stoichiometry
physical entity: Oxaloacetate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r72 173
type: Stoichiometry
physical entity: ADP + Pi
stoichiometric coefficient: 1.0

Pyruvate kinase
type: ProteinReference
xref: uniprot Q9FNN1 37
xref: PTHR11817:SF84
organism: Arabidopsis thaliana

uniprot O75390 147
type: UnificationXref
id: O75390
db: uniprot

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 102

uniprot I6YF40 91
type: UnificationXref
id: I6YF40
db: uniprot

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Pyruvate Kinase
type: Protein
entity reference: Pyruvate Kinase
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r72 170
type: Stoichiometry
physical entity: ATP + CoA-SH
stoichiometric coefficient: 1.0

uniprot P35487 52
type: UnificationXref
id: P35487
db: uniprot

uniprot Q9I3U4 143
type: UnificationXref
id: Q9I3U4
db: uniprot

Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
type: ProteinReference
xref: PTHR11561:SF1
xref: uniprot P07379 69
organism: Rattus norvegicus

ncbitaxon 13616 87
type: UnificationXref
id: 13616
db: ncbitaxon

ncbitaxon 36329 129
type: UnificationXref
id: 36329
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r72 169
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

NAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000303 63

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 19

uniprot O24457 44
type: UnificationXref
id: O24457
db: uniprot

Pyruvate Carboxylase
type: Protein
entity reference: Pyruvate Carboxylase
comment: SPECIES_TYPE=PROTEIN

PTHR11540:SF16
type: RelationshipXref
id: PTHR11540:SF16
db: PANTHER Family
relationship type: By Homology

uniprot O84247 45
type: UnificationXref
id: O84247
db: uniprot

ncbitaxon 243232 117
type: UnificationXref
id: 243232
db: ncbitaxon

Probable dehydrogenase
type: ProteinReference
xref: uniprot I6XWE5 43
xref: PTHR11516:SF41
organism: Mycobacterium tuberculosis

PTHR23382:SF0
type: RelationshipXref
id: PTHR23382:SF0
db: PANTHER Family
relationship type: By Homology

Citrate synthase, mitochondrial
type: ProteinReference
xref: PTHR11739:SF8
xref: uniprot O75390 147
organism: Homo sapiens

NADPH + H+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Pyruvate kinase
type: ProteinReference
xref: uniprot F7FI39 12
organism: Macaca mulatta

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 18

NAD+ + CoA-SH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A6QL68 83
type: UnificationXref
id: A6QL68
db: uniprot

uniprot H2R314 90
type: UnificationXref
id: H2R314
db: uniprot

uniprot Q9CZU6 158
type: UnificationXref
id: Q9CZU6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTP-_Acetyl_CoA-RIGHT__Phosphoenolpyruvate-_GDP__PLUS__CO2-_r76
controller: Phosphoenolpyruvate Carboxykinase

Pyruvate kinase PKLR
type: ProteinReference
xref: uniprot P53657 26
organism: Mus musculus

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Citrate Synthetase
type: Protein
entity reference: Citrate Synthetase
comment: SPECIES_TYPE=PROTEIN

uniprot Q9K3H0 60
type: UnificationXref
id: Q9K3H0
db: uniprot

uniprot P00548 15
type: UnificationXref
id: P00548
db: uniprot

uniprot A8X188 8
type: UnificationXref
id: A8X188
db: uniprot

Pyruvate kinase
type: ProteinReference
xref: PTHR11817:SF3
xref: uniprot Q8ZYE0 33
organism: Pyrobaculum aerophilum

STATE_TRANSITION_LEFT__Alanine-RIGHT__Pyruvate-_r73
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 168
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 167
left: Alanine
interaction type: STATE_TRANSITION
right: Pyruvate

uniprot Q8ZSU1 157
type: UnificationXref
id: Q8ZSU1
db: uniprot

Citrate synthase, mitochondrial
type: ProteinReference
xref: uniprot P34085 151
xref: PTHR11739:SF8
organism: Neurospora crassa

ncbitaxon 7227 71
type: UnificationXref
id: 7227
db: ncbitaxon

ncbitaxon 9598 3
type: UnificationXref
id: 9598
db: ncbitaxon

ATP-citrate synthase
type: ProteinReference
xref: uniprot P16638 94
organism: Rattus norvegicus

ncbitaxon 9544 13
type: UnificationXref
id: 9544
db: ncbitaxon

ncbitaxon 6239 32
type: UnificationXref
id: 6239
db: ncbitaxon

STATE_TRANSITION_LEFT__NADP_PLUS_-_Malate-RIGHT__NADPH__PLUS__H_PLUS__PLUS__CO2-_Pyruvate-_r64
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 192
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 193
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 190
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 191
left: Malate
left: NADP+
interaction type: STATE_TRANSITION
right: Pyruvate
right: NADPH + H++ CO2

ATP + HCO3 -
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q80X68 155
type: UnificationXref
id: Q80X68
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

PTHR11817:SF101
type: RelationshipXref
id: PTHR11817:SF101
db: PANTHER Family
relationship type: By Homology

ATP-citrate synthase
type: ProteinReference
xref: uniprot A0A1D5PSE5 82
organism: Gallus gallus

uniprot Q9K3V6 159
type: UnificationXref
id: Q9K3V6
db: uniprot

uniprot F6ZDT7 67
type: UnificationXref
id: F6ZDT7
db: uniprot

Pyruvate kinase
type: ProteinReference
xref: uniprot F6W2Y6 10
xref: PTHR11817:SF15
organism: Xenopus tropicalis

Pyruvate kinase 2
type: ProteinReference
xref: PTHR11817:SF3
xref: uniprot P73534 27
organism: Synechocystis

Pyruvate dehydrogenase E1 component subunit alpha
type: ProteinReference
xref: uniprot O84247 45
xref: PTHR11516:SF60
organism: Chlamydia trachomatis

uniprot Q9I492 118
type: UnificationXref
id: Q9I492
db: uniprot

uniprot P29803 50
type: UnificationXref
id: P29803
db: uniprot

uniprot F6SC45 132
type: UnificationXref
id: F6SC45
db: uniprot

uniprot P07379 69
type: UnificationXref
id: P07379
db: uniprot

ncbitaxon 559292 49
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot P9WKE5 29
type: UnificationXref
id: P9WKE5
db: uniprot

STATE_TRANSITION_LEFT__NAD_PLUS___PLUS__CoA_SH-_Pyruvate-RIGHT__Acetyl_CoA-_NADH__PLUS__CO2-_r68
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 177
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 175
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 174
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 176
left: Pyruvate
left: NAD+ + CoA-SH
interaction type: STATE_TRANSITION
right: NADH + CO2
right: Acetyl-CoA

uniprot G7MPT7 76
type: UnificationXref
id: G7MPT7
db: uniprot

uniprot H2R0Q3 89
type: UnificationXref
id: H2R0Q3
db: uniprot

uniprot Q05920 139
type: UnificationXref
id: Q05920
db: uniprot

ncbitaxon 6238 9
type: UnificationXref
id: 6238
db: ncbitaxon

PTHR48095:SF3
type: RelationshipXref
id: PTHR48095:SF3
db: PANTHER Family
relationship type: By Homology

ATP-citrate synthase
type: ProteinReference
xref: uniprot P53396 95
organism: Homo sapiens

ncbitaxon 64091 107
type: UnificationXref
id: 64091
db: ncbitaxon

PTHR42684:SF1
type: RelationshipXref
id: PTHR42684:SF1
db: PANTHER Family
relationship type: By Homology

uniprot O34736 114
type: UnificationXref
id: O34736
db: uniprot

uniprot Q9LU95 40
type: UnificationXref
id: Q9LU95
db: uniprot

uniprot A2FYF4 124
type: UnificationXref
id: A2FYF4
db: uniprot

uniprot A0A1D5R3J3 145
type: UnificationXref
id: A0A1D5R3J3
db: uniprot

NADH + CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Citrate lyase, beta subunit
type: ProteinReference
xref: uniprot Q9RSB9 109
organism: Deinococcus radiodurans

uniprot P11154 135
type: UnificationXref
id: P11154
db: uniprot

Citrate lyase subunit beta
type: ProteinReference
xref: uniprot P0A9I1 92
organism: Escherichia coli

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

ncbitaxon 227321 142
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot H2RBP4 14
type: UnificationXref
id: H2RBP4
db: uniprot

uniprot A0A2I3TKQ7 2
type: UnificationXref
id: A0A2I3TKQ7
db: uniprot

Malic enzyme
type: ProteinReference
xref: PTHR23406:SF17
xref: uniprot H2QTC2 77
organism: Pan troglodytes

ncbitaxon 83332 30
type: UnificationXref
id: 83332
db: ncbitaxon

Citrate Lyase
type: Protein
entity reference: Citrate Lyase
comment: SPECIES_TYPE=PROTEIN

uniprot P30613 23
type: UnificationXref
id: P30613
db: uniprot

Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial
type: ProteinReference
xref: PTHR11516:SF60
xref: uniprot Q6Z5N4 56
organism: Oryza sativa

HETERODIMER_ASSOCIATION_LEFT__Oxaloacetate-_Acetyl_CoA-RIGHT__Citrate-_r75
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 164
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 165
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 166
left: Oxaloacetate
left: Acetyl-CoA
interaction type: HETERODIMER_ASSOCIATION
right: Citrate

uniprot Q10489 54
type: UnificationXref
id: Q10489
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 142

uniprot Q9Z2V4 73
type: UnificationXref
id: Q9Z2V4
db: uniprot

Putative citratelyase
type: ProteinReference
xref: uniprot Q9ZBK3 113
organism: Streptomyces coelicolor

uniprot Q5I0K3 98
type: UnificationXref
id: Q5I0K3
db: uniprot

PARTICIPANT STOICHIOMETRY r76 163
type: Stoichiometry
physical entity: GDP + CO2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r76 162
type: Stoichiometry
physical entity: Phosphoenolpyruvate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r76 161
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r76 160
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0